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Explain the mechanism of interaction between Vemurafenib and Telithromycin. | Synergy | 99,826 |
Explain the mechanism of interaction between Insulin human (regular) and Triamcinolone (topical). | Antagonism | 19,960 |
How should the interaction between Codeine and Methdilazine be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 432,732 |
What is the interaction between Orphenadrine and Duloxetine? | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.
abdominal pain alcohol consumption anaphylactic reaction Aching joints bleb chest pain cognitive disorder Cough cyst dizziness More | 655,946 |
How should the interaction between Zanubrutinib and Heparin be managed? Describe the necessary steps. | Concomitant use of zanubrutinib in patients receiving other medications that interfere with platelet function or coagulation should be approached with caution. Close clinical and laboratory monitoring for bleeding complications is recommended during therapy. Patients should be advised to promptly report any signs and symptoms of bleeding to their physician. Discontinue zanubrutinib if intracranial hemorrhage of any grade occurs. | 800,033 |
Explain the mechanism of interaction between Acrivastine and Trospium. | Synergy | 785,174 |
What is the interaction between Insulin aspart (aspart protamine) and Paroxetine? | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines, amylin analogs, anabolic steroids, fibrates, monoamine oxidase inhibitors (MAOIs, including linezolid), salicylates, selective serotonin reuptake inhibitors (SSRIs), sulfonamides, disopyramide, propoxyphene, quinidine, quinine, and ginseng. These drugs may increase the risk of hypoglycemia by enhancing insulin sensitivity (ACE inhibitors, ARBs, fibrates, ginseng); stimulating insulin secretion (salicylates, disopyramide, pentoxifylline, propoxyphene, quinidine, quinine, MAOIs, ginseng); decreasing insulin clearance and resistance (4-aminoquinolines); increasing peripheral glucose utilization (SSRIs, insulin-like growth factor); inhibiting gluconeogenesis (SSRIs, MAOIs, insulin-like growth factor); slowing the rate of gastric emptying (amylin analogs); and/or suppressing postprandial glucagon secretion (amylin analogs). Clinical hypoglycemia has been reported during use of some of these agents alone or with insulin and/or insulin secretagogues. | 63,852 |
What is the interaction between Revefenacin and Protriptyline? | The potential exists for additive anticholinergic effects such as mydriasis, blurred vision, heat intolerance, fever, dry mouth, tachycardia, urinary retention, constipation, and glaucoma (onset or exacerbation) when topical or inhaled anticholinergic agents are used with each other or with other agents that possess anticholinergic properties. The risk of systemic anticholinergic effects following topical administration depends on variables such as strength of the product, size of the application area, frequency of application, and use of occlusive dressing. Systemic effects are uncommon following oral inhalation or nasal administration due to the poor absorption of quaternary ammonium compounds from gastrointestinal and nasal mucosa. | 762,877 |
What is the interaction between Cobimetinib and Remdesivir? | Concomitant use of remdesivir with other agents that are known to induce hepatotoxicity may theoretically increase the risk of liver injury. Data from investigational use and clinical studies suggest that remdesivir may be associated with hepatotoxic effects. | 1,361,179 |
What is the interaction between Pramlintide and Triamcinolone? | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics, estrogens, gonadotropin-releasing hormone agonists, human growth hormone, phenothiazines, progestins, protease inhibitors, sympathomimetic amines, thyroid hormones, L-asparaginase, alpelisib, copanlisib, danazol, diazoxide, isoniazid, megestrol, omacetaxine, phenytoin, tagraxofusp, temsirolimus, as well as pharmacologic dosages of nicotinic acid and adrenocorticotropic agents. These drugs may interfere with blood glucose control because they can cause hyperglycemia, glucose intolerance, new-onset diabetes mellitus, and/or exacerbation of preexisting diabetes. | 591,613 |
Explain the mechanism of interaction between Oxycodone and Rufinamide. | Metabolism | 1,031,233 |
How should the interaction between Hydroxyzine and Sevoflurane be managed? Describe the necessary steps. | Caution is recommended if sevoflurane is used in combination with other drugs that can prolong the QT interval. The patient's cardiovascular status and serum electrolytes should be closely monitored. | 141,534 |
How should the interaction between Fosamprenavir and Simvastatin be managed? Describe the necessary steps. | Simvastatin or lovastatin are considered contraindicated in patients treated with fosamprenavir due to the potential for severe interaction. Red yeast rice (which contains lovastatin) should also be avoided in patients treated with PIs. Fluvastatin and pravastatin are probably safer alternatives, since they are not metabolized by CYP450 3A4. All patients treated with HMG-CoA reductase inhibitors should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. Therapy should be discontinued if creatine kinase is markedly elevated in the absence of strenuous exercise or if myopathy is otherwise suspected or diagnosed. | 329,211 |
What is the severity level of interaction between Ribociclib and Droperidol? | Major | 369,419 |
What is the severity level of interaction between Brimonidine (topical) and Nitroprusside? | Moderate | 1,102,750 |
What is the interaction between Insulin degludec and Moexipril? | The hypoglycemic effect of insulin may be potentiated by certain drugs, including ACE inhibitors, angiotensin receptor blockers (ARBs), 4-aminoquinolines, amylin analogs, anabolic steroids, fibrates, monoamine oxidase inhibitors (MAOIs, including linezolid), salicylates, selective serotonin reuptake inhibitors (SSRIs), sulfonamides, disopyramide, propoxyphene, quinidine, quinine, and ginseng. These drugs may increase the risk of hypoglycemia by enhancing insulin sensitivity (ACE inhibitors, ARBs, fibrates, ginseng); stimulating insulin secretion (salicylates, disopyramide, pentoxifylline, propoxyphene, quinidine, quinine, MAOIs, ginseng); decreasing insulin clearance and resistance (4-aminoquinolines); increasing peripheral glucose utilization (SSRIs, insulin-like growth factor); inhibiting gluconeogenesis (SSRIs, MAOIs, insulin-like growth factor); slowing the rate of gastric emptying (amylin analogs); and/or suppressing postprandial glucagon secretion (amylin analogs). Clinical hypoglycemia has been reported during use of some of these agents alone or with insulin and/or insulin secretagogues. | 1,307,132 |
Explain the mechanism of interaction between Doxylamine and Fosphenytoin. | Synergy | 1,379,670 |
What is the interaction between Nimodipine and Vecuronium? | Some calcium channel blockers may enhance the neuromuscular blocking properties of nondepolarizing muscle relaxants. The mechanism is not known, but may involve blockage of calcium channels on skeletal muscle. Data are available for verapamil, diltiazem, nicardipine, atracurium, vecuronium, and pancuronium. | 1,032,613 |
What is the interaction between Fosphenytoin and Sorafenib? | Coadministration with potent inducers of CYP450 3A4 may decrease the plasma concentrations of sorafenib, which is partially metabolized by the isoenzyme. | 908,971 |
Explain the mechanism of interaction between Azatadine and Oliceridine. | Synergy | 673,427 |
How should the interaction between Melphalan flufenamide and Clostridium tetani toxoid antigen (formaldehyde inactivated) be managed? Describe the necessary steps. | In general, the US Department of Public Health Advisory Committee on Immunization Practices (ACIP) recommends that inactivated or killed vaccines be administered to non-HIV immunosuppressed patients according to the same guidelines as for healthy patients. For Haemophilus influenzae b vaccine, some experts recommend that it be administered at least 2 weeks before starting or 3 months after discontinuing chemotherapy when used in patients with Hodgkin's disease. For rabies vaccine, some authorities suggest that immunosuppressive agents should generally be avoided during postexposure therapy except when absolutely necessary for the treatment of other conditions. | 1,202,004 |
How should the interaction between Ivacaftor and Fesoterodine be managed? Describe the necessary steps. | Close clinical and laboratory monitoring is advised whenever a CYP450 3A4 inhibitor is added to or withdrawn from fesoterodine therapy, and the dosage adjusted if necessary. Patients should be advised to notify their physician if they experience potential adverse effects of fesoterodine such as irregular heartbeat, blurry vision, difficulty urinating, dry mouth, headache, drowsiness, dizziness, gastrointestinal upset, or constipation. | 650,103 |
What is the interaction between Fluticasone (topical) and Insulin lispro? | The efficacy of insulin and other antidiabetic agents may be diminished by topical corticosteroids, particularly during prolonged or indiscriminate use. Corticosteroids can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis. The duration of administration Close clinical monitoring of glycemic control is recommended if topical corticosteroids are administered chronically and/or to large areas in diabetic patients. | 265,155 |
How should the interaction between Budesonide and Fosinopril be managed? Describe the necessary steps. | Patients on prolonged (i.e., longer than about a week) or high-dose corticosteroid therapy should have blood pressure, electrolyte levels, and body weight monitored regularly, and be observed for the development of edema and congestive heart failure. The dosages of antihypertensive medications may require adjustment. | 289,932 |
What is the severity level of interaction between Racepinephrine and Betaxolol? | Moderate | 1,129,238 |
Explain the mechanism of interaction between Nebivolol and Phenelzine. | Synergy | 300,282 |
Explain the mechanism of interaction between Tetracycline and Aminolevulinic acid (topical). | Synergy | 825,841 |
Explain the mechanism of interaction between Ribociclib and Ocrelizumab. | Synergy | 479,051 |
What is the interaction between Niacin and Sitagliptin? | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics, estrogens, gonadotropin-releasing hormone agonists, human growth hormone, phenothiazines, progestins, protease inhibitors, sympathomimetic amines, thyroid hormones, L-asparaginase, alpelisib, copanlisib, danazol, diazoxide, isoniazid, megestrol, omacetaxine, phenytoin, tagraxofusp, temsirolimus, as well as pharmacologic dosages of nicotinic acid and adrenocorticotropic agents. These drugs may interfere with blood glucose control because they can cause hyperglycemia, glucose intolerance, new-onset diabetes mellitus, and/or exacerbation of preexisting diabetes. | 1,371,153 |
How should the interaction between Disopyramide and Rocuronium be managed? Describe the necessary steps. | While more data are needed, it is recommended that the clinician be aware of a potential interaction in patients who have taken disopyramide. | 1,087,974 |
Explain the mechanism of interaction between Diazepam and Halazepam. | Synergy | 597,072 |
Explain the mechanism of interaction between Fluphenazine and Delafloxacin. | Synergy | 428,026 |
What is the interaction between Clozapine and Isosorbide? | Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking activity. Orthostatic hypotension and syncope associated with vasodilation may occur, particularly during initial dosing and/or parenteral administration of the phenothiazine or neuroleptic. | 801,584 |
What is the severity level of interaction between Paliperidone and Clidinium? | Moderate | 84,940 |
What is the severity level of interaction between Somapacitan and Progesterone? | Moderate | 1,296,001 |
What is the interaction between Carboplatin and Cytarabine (liposomal)? | The concomitant or sequential administration of multiple antineoplastic agents may result in additive toxicities, particularly in the bone marrow and gastrointestinal tract.
agranulocytoses amyloidosis cerebral haemorrhage CMV infection Diplopia esophageal perforation Bleeding gums glioma Head ache cardiac disease More | 818,029 |
What is the interaction between Dronabinol and Metyrosine? | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. | 1,312,641 |
Explain the mechanism of interaction between Telaprevir and Panobinostat. | Metabolism | 205,894 |
What is the interaction between Streptokinase and Aminocaproic acid? | Coadministration of an antifibrinolytic agent (e.g., aminocaproic acid, tranexamic acid, aprotinin) in combination with a tissue plasminogen activator (t-PA) may reduce the therapeutic effects of both drugs due to opposing pharmacodynamic actions. Aminocaproic acid and tranexamic acid are competitive inhibitors of plasminogen activation. At high concentrations they can also directly inhibit plasmin, which is needed for the degradation of fibrin and thrombolysis. Aprotinin is a broad-spectrum protease inhibitor that inhibits plasmin. It is known to have antifibrinolytic activity and may interact with t-PAs in a similar fashion. | 445,079 |
What is the interaction between Lomitapide and Flibanserin? | Coadministration with weak inhibitors of CYP450 3A4 may increase the plasma concentrations of flibanserin, which is primarily metabolized by CYP450 3A4 and, to a lesser extent, by CYP450 2C19. | 967,133 |
How should the interaction between Tipranavir and Cholic Acid be managed? Describe the necessary steps. | Concomitant use of cholic acid with drugs that inhibit canalicular membrane bile acid transporters such as the BSEP should generally be avoided. If coadministration is required, close monitoring of serum transaminases and bilirubin is recommended. In addition, serum and urine bile acid levels should be monitored, and the cholic acid dose adjusted accordingly. | 183,308 |
How should the interaction between Cyproheptadine and Eslicarbazepine be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 764,823 |
How should the interaction between Somapacitan and Doxorubicin (liposomal) be managed? Describe the necessary steps. | Concomitant use of doxorubicin with CYP450 3A4 inducers should generally be avoided, particularly potent ones like carbamazepine, enzalutamide, lumacaftor, mitotane, phenobarbital, phenytoin, primidone (partially metabolized to phenobarbital), rifamycins, and St. John's wort. Close monitoring for potentially reduced efficacy of doxorubicin is recommended if coadministration is required. | 657,500 |
How should the interaction between Dolutegravir and Magnesium chloride be managed? Describe the necessary steps. | Dolutegravir should be administered 2 hours before or 6 hours after medications containing polyvalent cations such as antacids, laxatives, or mineral supplements. | 200,545 |
How should the interaction between Zidovudine and Cerivastatin be managed? Describe the necessary steps. | Clinicians should carefully consider the benefits versus risks prior to prescribing these agents together. Patients should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. | 1,368,669 |
What is the interaction between Magnesium citrate and Lofexidine? | Bowel cleansing as well as overuse of certain laxatives may cause electrolyte loss and increase the risk of torsade de pointes ventricular arrhythmia in patients treated with drugs that prolong the QT interval. Electrolyte disturbances including hypokalemia and hypomagnesemia have been reported with laxative abuse and are known risk factors for torsade de pointes associated with QT interval prolongation. | 1,243,709 |
What is the severity level of interaction between Pimozide and Peginterferon alfa-2b? | Moderate | 1,078,670 |
What is the interaction between Nabilone and Asenapine? | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. | 711,460 |
What is the interaction between Levonordefrin and Lumateperone? | Phenothiazines and other neuroleptics may inhibit or reverse the pressor effect of adrenaline (epinephrine), dopamine, and similar vasoconstrictors. Many of these agents, including the atypical antipsychotics, exhibit alpha-1 adrenergic blocking activity and produce hypotension as an adverse effect. Use of adrenaline or dopamine for drug-induced hypotension and circulatory collapse in patients receiving neuroleptic therapy may cause a paradoxical further lowering of blood pressure, since beta stimulation may worsen hypotension in the setting of alpha blockade. | 219,339 |
What is the interaction between Abemaciclib and Diltiazem? | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of abemaciclib and its pharmacologically active metabolites, all of which are substrates of the isoenzyme. | 1,186,405 |
What is the interaction between Methylene blue and Olodaterol? | Monoamine oxidase inhibitors (MAOIs) can potentiate the cardiovascular adverse effects of beta-2 adrenergic agonists such as hypertension, palpitation, tachycardia, and chest pain. | 622,348 |
How should the interaction between Azatadine and Sertraline be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 1,313,345 |
Explain the mechanism of interaction between Pramipexole and Dexmedetomidine. | Synergy | 462,622 |
What is the severity level of interaction between Ethionamide and Elotuzumab? | Moderate | 320,955 |
What is the interaction between Lisdexamfetamine and Ketoconazole? | Limited data suggests the lisdexamfetamine may rarely prolong the QT interval of the electrocardiogram in some patients. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including ventricular tachycardia, torsade de pointes, and sudden death. | 955,555 |
What is the interaction between Fluvoxamine and Vinblastine? | Coadministration with fluvoxamine may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to competitive inhibition of CYP450 3A4 activity by fluvoxamine. | 332,262 |
Explain the mechanism of interaction between Tiotropium and Insulin human (inhalation, rapid acting). | Absorption | 64,686 |
What is the severity level of interaction between Labetalol and Succinylcholine? | Moderate | 1,347,627 |
What is the severity level of interaction between Fosphenytoin and Primidone? | Moderate | 31,117 |
Explain the mechanism of interaction between Nintedanib and Bivalirudin. | Synergy | 809,433 |
What is the severity level of interaction between Alefacept and Coccidioides immitis spherule? | Moderate | 964,890 |
What is the severity level of interaction between Nebivolol and Rolapitant? | Moderate | 826,300 |
What is the interaction between Trimethaphan and Iloperidone? | Phenothiazines and neuroleptic agents may potentiate the hypotensive effect of some medications secondary to their peripheral alpha-1 adrenergic blocking activity. Orthostatic hypotension and syncope associated with vasodilation may occur, particularly during initial dosing and/or parenteral administration of the phenothiazine or neuroleptic. | 1,238,389 |
What is the interaction between Certolizumab pegol and Rotavirus vaccine? | The administration of live, attenuated viral or bacterial vaccines during immunosuppressant or intense antineoplastic therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Patients may be immunosuppressed if they have recently received or are receiving alkylating agents, antimetabolites, radiation, some antirheumatic agents, high dosages of corticosteroids or adrenocorticotropic agents, or long-term topical or inhaled corticosteroids. These patients may also have increased adverse reactions and decreased or suboptimal immunologic response to vaccines. | 276,077 |
What is the interaction between Propranolol and Vecuronium? | Neuromuscular blocking agents and beta-blockers may have additive cardiovascular depressant effects. Limited data suggest that beta-blockers may modestly potentiate the pharmacologic effects of neuromuscular blocking agents. The exact mechanism of interaction is unknown but may involve effects in the postsynaptic membrane, as beta-blockers alone have been reported to exacerbate or unmask myasthenia gravis.
Apnea Arrhythmia atrioventricular block asystole Cardiac decompensation Bleeding High blood pressure arterial pressure NOS decreased atrial ectopic beats pyoderma More | 1,032,101 |
Explain the mechanism of interaction between Pimozide and Iopamidol. | Synergy | 894,254 |
Explain the mechanism of interaction between Clarithromycin and Clozapine. | Metabolism | 971,414 |
What is the interaction between Topotecan and Zidovudine? | Coadministration of zidovudine with other bone marrow depressive or cytotoxic agents may increase the risk and/or severity of zidovudine hematologic toxicity. Zidovudine has been associated with hematologic toxicities such as: neutropenia, granulocytopenia and severe anemia that required blood transfusions particularly in patients with advanced HIV disease. | 818,157 |
What is the severity level of interaction between Siltuximab and Canakinumab? | Moderate | 75,458 |
Explain the mechanism of interaction between Cyclosporine and Chlorothiazide. | Others | 1,360,680 |
Explain the mechanism of interaction between Paliperidone and Droperidol. | Synergy | 246,240 |
Explain the mechanism of interaction between Promazine and Belladonna. | Synergy | 1,316,747 |
What is the interaction between Triprolidine and Flibanserin? | The central nervous system (CNS) effects of flibanserin such as somnolence and fatigue may be potentiated by concomitant use of other agents with CNS depressant effects. The risk of CNS depression is increased if flibanserin is taken during waking hours or with alcohol or other CNS depressants. | 607,022 |
Explain the mechanism of interaction between Triflupromazine and Rufinamide. | Synergy | 1,170,889 |
What is the interaction between Selegiline and Oxymetazoline (ophthalmic)? | By inhibiting the breakdown of catecholamines, monoamine oxidase inhibitors (MAOIs) may theoretically potentiate the cardiovascular effects of systemically absorbed sympathomimetic agents following topical administration (e.g., nasal decongestants, ophthalmic vasoconstrictors). | 1,183,659 |
What is the severity level of interaction between Morphine and Levacetylmethadol? | Major | 1,141,161 |
Explain the mechanism of interaction between Paroxetine and Vilazodone. | Synergy | 970,435 |
What is the interaction between Amiloride and Meperidine? | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis. | 823,523 |
What is the interaction between Rifabutin and Brigatinib? | Coadministration with moderate inducers of CYP450 3A4 may decrease the plasma concentrations of brigatinib, which is partially metabolized by the isoenzyme. | 417,146 |
What is the severity level of interaction between Rifapentine and Olaparib? | Major | 679,291 |
How should the interaction between Ramelteon and Clonidine be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 744,752 |
Explain the mechanism of interaction between Sibutramine and Trifluoperazine. | Synergy | 406,246 |
What is the severity level of interaction between Hydrochlorothiazide and Prednisolone? | Moderate | 125,443 |
What is the interaction between Ranolazine and Foscarnet? | Ranolazine can cause dose-related prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. | 1,225,468 |
How should the interaction between Vortioxetine and Quinidine be managed? Describe the necessary steps. | The dosage of vortioxetine should be reduced by one-half when used in combination with potent CYP450 2D6 inhibitors such as bupropion, cinacalcet, fluoxetine, paroxetine, quinidine, ritonavir, and terbinafine. Following discontinuation of the potent CYP450 2D6 inhibitor, vortioxetine dosage should be returned to the original level. Since fluoxetine and paroxetine are also selective serotonin reuptake inhibitors, additive serotonergic effects with vortioxetine should be considered, and concomitant use avoided if possible. | 1,160,719 |
What is the severity level of interaction between Pseudoephedrine and Levosalbutamol? | Moderate | 1,001,191 |
Explain the mechanism of interaction between Ticlopidine and Sulindac. | Synergy | 302,556 |
What is the severity level of interaction between Lumateperone and Topiramate? | Major | 898,742 |
What is the interaction between Lorlatinib and Troleandomycin? | Coadministration with potent inhibitors of CYP450 3A4 may increase the plasma concentrations of lorlatinib, which has been found to be metabolized primarily by CYP450 3A4 and UGT1A4 in vitro. Increased exposure to lorlatinib may increase the risk of central nervous system adverse effects (e.g., seizures, hallucinations, changes in cognitive function, mood disorders, mental status changes, sleep impairment), hyperlipidemia (hypercholesterolemia and hypertriglyceridemia), PR interval prolongation and atrioventricular (AV) block, and interstitial lung disease/pneumonitis. | 1,101,994 |
How should the interaction between Methadone and Rifapentine be managed? Describe the necessary steps. | Caution is advised if methadone is prescribed with CYP450 2B6, 2C19, 2C9 and/or 3A4 inducers. Pharmacologic response to methadone should be monitored more closely whenever an inducer is added to or withdrawn from therapy, and the dosage adjusted as necessary. | 621,081 |
Explain the mechanism of interaction between Penbutolol and Amitriptyline. | Synergy | 449,280 |
What is the interaction between Epinephrine (ophthalmic) and Olodaterol? | Coadministration of beta-2 adrenergic agonists with other adrenergic agents may potentiate the risk of cardiovascular side effects. Beta-2 adrenergic agonists can produce clinically significant cardiovascular effects including increases in pulse rate and systolic or diastolic blood pressure as well as ECG changes such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. The risk is lower when beta-2 adrenergic agonists are inhaled at normally recommended dosages. | 623,423 |
What is the interaction between Rivastigmine and Imipramine? | Due to opposing effects, agents that possess anticholinergic activity (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; class IA antiarrhythmics especially disopyramide; carbamazepine; cimetidine; ranitidine) may negate the already small pharmacologic benefits of acetylcholinesterase inhibitors in the treatment of dementia. These agents may also adversely affect elderly patients in general. Clinically significant mental status changes associated with anticholinergic agents can range from mild cognitive impairment to delirium, and patients with Alzheimer's disease and other dementia are especially sensitive.
aortic regurgitation Arrhythmia AFIB cancer transient ischaemic attack arteriosclerotic heart disease Hallucination head injury hematoma subdural High blood pressure More | 765,116 |
Explain the mechanism of interaction between Posaconazole and Oxaliplatin. | Synergy | 234,025 |
How should the interaction between Suvorexant and Lithium carbonate be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 1,011,378 |
What is the severity level of interaction between Oxycodone and Pazopanib? | Major | 922,635 |
Explain the mechanism of interaction between Ziprasidone and Lisinopril. | Synergy | 565,422 |
What is the severity level of interaction between Treprostinil and Vitamin E? | Moderate | 243,293 |
Explain the mechanism of interaction between Inotuzumab ozogamicin and Hydroxyzine. | Synergy | 962,804 |
Explain the mechanism of interaction between Hydroxyzine and Methadone. | Synergy | 361,651 |