diff --git "a/demonstrations/kkidupr/axtrees/page-13-0.json" "b/demonstrations/kkidupr/axtrees/page-13-0.json"
new file mode 100644--- /dev/null
+++ "b/demonstrations/kkidupr/axtrees/page-13-0.json"
@@ -0,0 +1 @@
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"parentId": "417", "childIds": [], "backendDOMNodeId": 183}, {"nodeId": "471", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "AMR and One Health: Global Molecular Epidemiology of Resistant Bacteria", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "AMR and One Health: Global Molecular Epidemiology of Resistant Bacteria"}}]}, "properties": [], "parentId": "420", "childIds": [], "backendDOMNodeId": 214}, {"nodeId": "472", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Antibiotic resistance is a multi-sectoral global problem. It is increasingly important to look at AMR from a One Health perspective beyond the clinical setting, to include the animal, agricultural, environmental, and social factors that contribute to the emergence and dissemination of resistance globally. Recently, research into mechanisms of antibiotic resistance and current local and global epidemiology of resistant organisms are gaining interest, however research gaps and fragmented data is a recognizable problem, particularly in many low- and middle-income countries. Data is also significantly scarce from non-human sectors (animals, environment and agriculture) thereby creating knowledge gaps on accurate global burden and epidemiology of antibiotic resistance within the One Health framework. The goal of this research topic is to promote the generation of data and evidence on the global burden of antibiotic resistant bacteria, with particular interest in data from low- and middle-income countries. We encourage researchers to investigate different factors relating to the burden and transmission of antibiotic resistance, in order to propose realistic solutions to control the spread of antibiotic resistant bacteria in humans animals and in the environment. By researching the many factors relating to AMR epidemiology within One Health, the outcomes (both in the short- and long-term) will provide vital, contextual information to governments, policy makers, local-authorities, non-governmental organizations and other stakeholders about the determinants of health, illness and healthcare delivery and use.Themes and research scope of this research topic include: - Studies on the molecular epidemiology of resistant bacteria within One Health- Surveillance studies of environmental reservoirs of resistant bacteria- Studies involving the use of genomics in tracking transmission of resistant bacteria across multiple sectors- Intervention studies on infection, prevention and control in human and non-human sectors- Outbreak reports of resistant bacteria- Studies addressing One Health approaches for understanding cross-species transmission of antibiotic resistance", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Antibiotic resistance is a multi-sectoral global problem. It is increasingly important to look at AMR from a One Health perspective beyond the clinical setting, to include the animal, agricultural, environmental, and social factors that contribute to the emergence and dissemination of resistance globally. Recently, research into mechanisms of antibiotic resistance and current local and global epidemiology of resistant organisms are gaining interest, however research gaps and fragmented data is a recognizable problem, particularly in many low- and middle-income countries. Data is also significantly scarce from non-human sectors (animals, environment and agriculture) thereby creating knowledge gaps on accurate global burden and epidemiology of antibiotic resistance within the One Health framework. The goal of this research topic is to promote the generation of data and evidence on the global burden of antibiotic resistant bacteria, with particular interest in data from low- and middle-income countries. We encourage researchers to investigate different factors relating to the burden and transmission of antibiotic resistance, in order to propose realistic solutions to control the spread of antibiotic resistant bacteria in humans animals and in the environment. By researching the many factors relating to AMR epidemiology within One Health, the outcomes (both in the short- and long-term) will provide vital, contextual information to governments, policy makers, local-authorities, non-governmental organizations and other stakeholders about the determinants of health, illness and healthcare delivery and use.Themes and research scope of this research topic include: - Studies on the molecular epidemiology of resistant bacteria within One Health- Surveillance studies of environmental reservoirs of resistant bacteria- Studies involving the use of genomics in tracking transmission of resistant bacteria across multiple sectors- Intervention studies on infection, prevention and control in human and non-human sectors- Outbreak reports of resistant bacteria- Studies addressing One Health approaches for understanding cross-species transmission of antibiotic resistance"}}]}, "properties": [], "parentId": "421", "childIds": [], "backendDOMNodeId": 216}, {"nodeId": "473", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "422", "childIds": ["553"], "backendDOMNodeId": 223, "browsergym_id": "2e831b2c-9906-46db"}, {"nodeId": "474", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Characterization and Applications of Microbial Lipids in Food ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Characterization and Applications of Microbial Lipids in Food "}}]}, "properties": [], "parentId": "423", "childIds": [], "backendDOMNodeId": 225}, {"nodeId": "475", "ignored": false, "role": {"type": "role", "value": "mark"}, "chromeRole": {"type": "internalRole", "value": 119}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "423", "childIds": ["554"], "backendDOMNodeId": 226, "browsergym_id": "90bdac36-8ce3-49d8"}, {"nodeId": "476", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " and Nutraceuticals", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " and Nutraceuticals"}}]}, "properties": [], "parentId": "423", "childIds": [], "backendDOMNodeId": 228}, {"nodeId": "477", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Microorganisms produce lipids and oils for their essential structural and functional roles. However, only a relatively small number of microorganisms can accumulate cellular lipids up to 20-65% of their dry biomass \u2013 these are named oleaginous microorganisms.The main oleaginous microorganism includes fungi, yeasts, and microalgae. Different environmental factors can significantly affect the physiology and biochemistry of lipid accumulation, such as temperature, light, pH, and nutritional composition of culture media. Furthermore, microbial lipid production does not depend on geographic or climatic constraints, can rely on diverse carbon sources including agriculture and industrial wastes, and results in high yield. Over the past several years, unremitting efforts have been made to improve the economic competitiveness of microbial lipids over animal and plant-derived lipids, with several engineering approaches having also been developed to enhance the lipid production capabilities of microorganisms. Researchers are invited to submit to this Research Topic original research and review articles focusing on: 1.) Advances in Molecular biology and biochemistry of lipid accumulation in microorganisms.2.) Different fermentation strategies to attain high biomass and lipid yield.3.) Metabolic engineering of microorganisms for bioproducts.4.) Co-production of lipids with other secondary metabolites and their properties, such as anti-microbial, anti-cancerous, etc. 5). Use of oleaginous organisms to transform lipids into a variety of products including high-value fatty acids, neutral lipids, and volatile fatty acids.6.) Applications of microbial lipids in food and nutraceutical industries.This Research Topic aims to collect publications relevant to human nutrition only. Studies on farm animals, other than animal models for human nutrition, will not be accepted in this Research Topic and will be redirected to other relevant Frontiers journals.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Microorganisms produce lipids and oils for their essential structural and functional roles. However, only a relatively small number of microorganisms can accumulate cellular lipids up to 20-65% of their dry biomass \u2013 these are named oleaginous microorganisms.The main oleaginous microorganism includes fungi, yeasts, and microalgae. Different environmental factors can significantly affect the physiology and biochemistry of lipid accumulation, such as temperature, light, pH, and nutritional composition of culture media. Furthermore, microbial lipid production does not depend on geographic or climatic constraints, can rely on diverse carbon sources including agriculture and industrial wastes, and results in high yield. Over the past several years, unremitting efforts have been made to improve the economic competitiveness of microbial lipids over animal and plant-derived lipids, with several engineering approaches having also been developed to enhance the lipid production capabilities of microorganisms. Researchers are invited to submit to this Research Topic original research and review articles focusing on: 1.) Advances in Molecular biology and biochemistry of lipid accumulation in microorganisms.2.) Different fermentation strategies to attain high biomass and lipid yield.3.) Metabolic engineering of microorganisms for bioproducts.4.) Co-production of lipids with other secondary metabolites and their properties, such as anti-microbial, anti-cancerous, etc. 5). Use of oleaginous organisms to transform lipids into a variety of products including high-value fatty acids, neutral lipids, and volatile fatty acids.6.) Applications of microbial lipids in food and nutraceutical industries.This Research Topic aims to collect publications relevant to human nutrition only. Studies on farm animals, other than animal models for human nutrition, will not be accepted in this Research Topic and will be redirected to other relevant Frontiers journals."}}]}, "properties": [], "parentId": "424", "childIds": [], "backendDOMNodeId": 230}, {"nodeId": "478", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Manufacturing of Next-Generation Biologics", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Manufacturing of Next-Generation Biologics"}}]}, "properties": [], "parentId": "425", "childIds": [], "backendDOMNodeId": 237}, {"nodeId": "479", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Biotechnology and bioengineering have recently witnessed significant advancements in several areas, one of the most extensively-studied ones being the manufacturing of next-generation biologics. Those developments are the result of the synergistic contribution of both academic and industrial efforts focusing on multiple aspects of the drug manufacturing process. The success of currently emerging and established approaches and technologies in the field of biologics such as cancer immunotherapies, gene-therapy, mRNA delivery and erythrocytes-based drug delivery is largely dependent on the scaled manufacturing of high-quality biomacromolecules and cells. Thus, it is of prime importance to facilitate scientific communication among different groups and promote collaborative thinking around those efforts. The current Research Topic is focusing on the \u201cManufacturing of the Next-Generation Biologics\u201d by capturing milestone findings from both Industrial Biotechnology and Bioprocess Engineering to better serve academic & industrial communities.The goal of the present Research Topic is to capture important information related to advancements in the field of \u201cManufacturing of Next-Generation Biologics\u201d. Process optimization, downstream processing & purification optimization, formulation, PEGylation, antibody-conjugates, and Chemistry-Manufacturing-Controls (CMC) are just some topic examples that the current collection aims to cover. These methodologies are of particular interest in the following fields (but are not limited to): 1) cancer immunotherapy and the manufacturing of immune-checkpoint inhibitor antibodies; 2) gene therapy and the manufacturing of viral vectors; 3) mRNA delivery and 4) erythrocyte-based encapsulation of biologics. Cutting-edge, ongoing research in these fields will be selected for publication in this collection through the peer-review process, envisioning to add more to the fast-paced, growing broader area of bioengineering and biotechnology.The Research Topic 'Manufacturing of Next Generation Biologics' welcomes submissions related, but not limited to, the following areas:\u2022 Process optimization \u2022 Downstream processing\u2022 Chemistry-Manufacturing-Controls (CMC)\u2022 Gene therapy methodologies including viral vector production\u2022 mRNA delivery\u2022 Protein PEGylation optimization\u2022 Biologics encapsulation on erythrocytes \u2022 Generation & optimization of antibody-drug-conjugates", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Biotechnology and bioengineering have recently witnessed significant advancements in several areas, one of the most extensively-studied ones being the manufacturing of next-generation biologics. Those developments are the result of the synergistic contribution of both academic and industrial efforts focusing on multiple aspects of the drug manufacturing process. The success of currently emerging and established approaches and technologies in the field of biologics such as cancer immunotherapies, gene-therapy, mRNA delivery and erythrocytes-based drug delivery is largely dependent on the scaled manufacturing of high-quality biomacromolecules and cells. Thus, it is of prime importance to facilitate scientific communication among different groups and promote collaborative thinking around those efforts. The current Research Topic is focusing on the \u201cManufacturing of the Next-Generation Biologics\u201d by capturing milestone findings from both Industrial Biotechnology and Bioprocess Engineering to better serve academic & industrial communities.The goal of the present Research Topic is to capture important information related to advancements in the field of \u201cManufacturing of Next-Generation Biologics\u201d. Process optimization, downstream processing & purification optimization, formulation, PEGylation, antibody-conjugates, and Chemistry-Manufacturing-Controls (CMC) are just some topic examples that the current collection aims to cover. These methodologies are of particular interest in the following fields (but are not limited to): 1) cancer immunotherapy and the manufacturing of immune-checkpoint inhibitor antibodies; 2) gene therapy and the manufacturing of viral vectors; 3) mRNA delivery and 4) erythrocyte-based encapsulation of biologics. Cutting-edge, ongoing research in these fields will be selected for publication in this collection through the peer-review process, envisioning to add more to the fast-paced, growing broader area of bioengineering and biotechnology.The Research Topic 'Manufacturing of Next Generation Biologics' welcomes submissions related, but not limited to, the following areas:\u2022 Process optimization \u2022 Downstream processing\u2022 Chemistry-Manufacturing-Controls (CMC)\u2022 Gene therapy methodologies including viral vector production\u2022 mRNA delivery\u2022 Protein PEGylation optimization\u2022 Biologics encapsulation on erythrocytes \u2022 Generation & optimization of antibody-drug-conjugates"}}]}, "properties": [], "parentId": "426", "childIds": [], "backendDOMNodeId": 239}, {"nodeId": "480", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": 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