diff --git "a/demonstrations/klzknvr/axtrees/page-98-0.json" "b/demonstrations/klzknvr/axtrees/page-98-0.json"
new file mode 100644--- /dev/null
+++ "b/demonstrations/klzknvr/axtrees/page-98-0.json"
@@ -0,0 +1 @@
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A recent, eventually the first "}}]}, "properties": [], "parentId": "677", "childIds": [], "backendDOMNodeId": 940}, {"nodeId": "1015", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "677", "childIds": ["1802"], "backendDOMNodeId": 941, "browsergym_id": "2e5f5182-2639-4078"}, {"nodeId": "1016", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " study on duodenal biopsy specimens looking for alpha-syn pathology in PD patients and healthy individuals showed marked immunoreactivity for aggregated alpha-syn in every studied specimen of PD patient whereas the corresponding immunoreactivity was either absent or only barely detectable in controls (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " study on duodenal biopsy specimens looking for alpha-syn pathology in PD patients and healthy individuals showed marked immunoreactivity for aggregated alpha-syn in every studied specimen of PD patient whereas the corresponding immunoreactivity was either absent or only barely detectable in controls ("}}]}, "properties": [], "parentId": "677", "childIds": [], "backendDOMNodeId": 943}, {"nodeId": "1017", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Emmi et\u00a0al., 2023", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Emmi et\u00a0al., 2023"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "677", "childIds": ["1803"], "backendDOMNodeId": 944, "browsergym_id": "4a52d1f3-5521-44c6"}, {"nodeId": "1018", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). Neuropathological observations and analyses have justified a hypothesis that a pathogen in the gut may induce alphasyn aggregation, which then spreads ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "). Neuropathological observations and analyses have justified a hypothesis that a pathogen in the gut may induce alphasyn aggregation, which then spreads "}}]}, "properties": [], "parentId": "677", "childIds": [], "backendDOMNodeId": 946}, {"nodeId": "1019", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "677", "childIds": ["1804"], "backendDOMNodeId": 947, "browsergym_id": "ba562d36-14ac-49dc"}, {"nodeId": "1020", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " the vagal nerve to the central nervous system in the brain (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " the vagal nerve to the central nervous system in the brain ("}}]}, "properties": [], "parentId": "677", "childIds": [], "backendDOMNodeId": 949}, {"nodeId": "1021", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Braak et\u00a0al., 2006", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Braak et\u00a0al., 2006"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "677", "childIds": ["1805"], "backendDOMNodeId": 950, "browsergym_id": "633016cc-25ee-4cd5"}, {"nodeId": "1022", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). Alpha-syn is expressed in enteroendocrine cells, which are neuron-like cells residing with the greatest frequency in the small intestine (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "). Alpha-syn is expressed in enteroendocrine cells, which are neuron-like cells residing with the greatest frequency in the small intestine ("}}]}, "properties": [], "parentId": "677", "childIds": [], "backendDOMNodeId": 952}, {"nodeId": "1023", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Sj\u00f6lund et\u00a0al., 1983", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Sj\u00f6lund et\u00a0al., 1983"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "677", "childIds": ["1806"], "backendDOMNodeId": 953, "browsergym_id": "f4dfbbf3-5253-4fc5"}, {"nodeId": "1024", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": ") and connected to the enteric alpha-syn containing nerves (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": ") and connected to the enteric alpha-syn containing nerves ("}}]}, "properties": [], "parentId": "677", "childIds": [], "backendDOMNodeId": 955}, {"nodeId": "1025", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Chandra et\u00a0al., 2017", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Chandra et\u00a0al., 2017"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "677", "childIds": ["1807"], "backendDOMNodeId": 956, "browsergym_id": "af92e58c-3b65-449a"}, {"nodeId": "1026", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). Based on this finding, Chandra et\u00a0al. have proposed that alpha-syn aggregation is likely initiated in the enteroendocrine cells by the action of an intestinal pathogen; alpha-syn aggregates then spread in a prion-like manner from the gut to the brain ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "). 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Various ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains to interact with gastrointestinal cells. Various "}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1787}, {"nodeId": "1463", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "747", "childIds": ["2088"], "backendDOMNodeId": 1788, "browsergym_id": "2de05cb1-4a55-4b5c"}, {"nodeId": "1464", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " strains have been shown to adhere to the epithelial cell surface, invade into the cell cytoplasm, and replicate within the cells (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains have been shown to adhere to the epithelial cell surface, invade into the cell cytoplasm, and replicate within the cells ("}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1790}, {"nodeId": "1465", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Bisson-Boutelliez et\u00a0al., 2010", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Bisson-Boutelliez et\u00a0al., 2010"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "747", "childIds": ["2089"], "backendDOMNodeId": 1791, "browsergym_id": "08223d81-f12a-4c03"}, {"nodeId": "1466", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). Interestingly, sulfate-reducing bacteria (SRB), to which group ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "). Interestingly, sulfate-reducing bacteria (SRB), to which group "}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1793}, {"nodeId": "1467", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "747", "childIds": ["2090"], "backendDOMNodeId": 1794, "browsergym_id": "db38a2c9-2fc3-425b"}, {"nodeId": "1468", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " bacteria belongs, have been shown to induce apoptosis of human colonic epithelial cells when the SRB enrichments originated from patients suffering from ulcerative colitis, whereas this response did not take place when SRB enrichments originated from healthy individuals (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " bacteria belongs, have been shown to induce apoptosis of human colonic epithelial cells when the SRB enrichments originated from patients suffering from ulcerative colitis, whereas this response did not take place when SRB enrichments originated from healthy individuals ("}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1796}, {"nodeId": "1469", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Coutinho et\u00a0al., 2017", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Coutinho et\u00a0al., 2017"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "747", "childIds": ["2091"], "backendDOMNodeId": 1797, "browsergym_id": "8d76b611-edae-4bc0"}, {"nodeId": "1470", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). Taking these two studies into consideration, it is reasonable to presume that pathogenic ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "). Taking these two studies into consideration, it is reasonable to presume that pathogenic "}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1799}, {"nodeId": "1471", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "747", "childIds": ["2092"], "backendDOMNodeId": 1800, "browsergym_id": "a0513348-2f68-4045"}, {"nodeId": "1472", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " strains damage and impair intestinal barrier integrity and function. This would, firstly, lead to further ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains damage and impair intestinal barrier integrity and function. This would, firstly, lead to further "}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1802}, {"nodeId": "1473", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "747", "childIds": ["2093"], "backendDOMNodeId": 1803, "browsergym_id": "409b6834-3db8-4be6"}, {"nodeId": "1474", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " colonization of the human gut and allow interaction with surrounding cells, such as enteroendocrine cells, resulting in increased alpha-syn aggregation as proposed in the ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " colonization of the human gut and allow interaction with surrounding cells, such as enteroendocrine cells, resulting in increased alpha-syn aggregation as proposed in the "}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1805}, {"nodeId": "1475", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "747", "childIds": ["2094"], "backendDOMNodeId": 1806, "browsergym_id": "124d2b0b-03e0-427a"}, {"nodeId": "1476", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "-PD pathogenesis model (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "-PD pathogenesis model ("}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1808}, {"nodeId": "1477", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Murros et\u00a0al., 2021", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Murros et\u00a0al., 2021"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "747", "childIds": ["2095"], "backendDOMNodeId": 1809, "browsergym_id": "1e4584ba-a7e6-447d"}, {"nodeId": "1478", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). Secondly, damaged and dysfunctional intestinal barrier would eventually lead to intestinal inflammation. Inflammation in the intestine can be an underlying mechanism driving PD pathogenesis as it plays a part in the relationship between gut dysbiosis, immune responses and alpha-syn pathology (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "). Secondly, damaged and dysfunctional intestinal barrier would eventually lead to intestinal inflammation. Inflammation in the intestine can be an underlying mechanism driving PD pathogenesis as it plays a part in the relationship between gut dysbiosis, immune responses and alpha-syn pathology ("}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1811}, {"nodeId": "1479", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Houser and Tansey, 2017", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Houser and Tansey, 2017"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "747", "childIds": ["2096"], "backendDOMNodeId": 1812, "browsergym_id": "bdc98004-ec9f-4f9d"}, {"nodeId": "1480", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). 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Lipopolysaccharides have been shown to modulate alpha-syn aggregation (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " bacteria, may be an additional virulence factor. Lipopolysaccharides have been shown to modulate alpha-syn aggregation ("}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1829}, {"nodeId": "1491", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Bhattacharyya et\u00a0al., 2019", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Bhattacharyya et\u00a0al., 2019"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "747", "childIds": ["2102"], "backendDOMNodeId": 1830, "browsergym_id": "0eee4de4-e69e-4a28"}, {"nodeId": "1492", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": ") and enhance plasma H", "sources": [{"type": "contents", "value": {"type": "computedString", "value": ") and enhance plasma H"}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1832}, {"nodeId": "1493", "ignored": false, "role": {"type": "role", "value": "subscript"}, "chromeRole": {"type": "internalRole", "value": 185}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "747", "childIds": ["2103"], "backendDOMNodeId": 1833, "browsergym_id": "0ee07c5f-e505-4dde"}, {"nodeId": "1494", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "S concentration in mice (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "S concentration in mice ("}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1835}, {"nodeId": "1495", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Li et\u00a0al., 2005", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Li et\u00a0al., 2005"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "747", "childIds": ["2104"], "backendDOMNodeId": 1836, "browsergym_id": "f9241177-87e3-4268"}, {"nodeId": "1496", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). Of further interest, lipopolysaccharides of different ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "). Of further interest, lipopolysaccharides of different "}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1838}, {"nodeId": "1497", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "747", "childIds": ["2105"], "backendDOMNodeId": 1839, "browsergym_id": "305db99d-20c7-41b9"}, {"nodeId": "1498", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " strains are diverse in structure (", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains are diverse in structure ("}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1841}, {"nodeId": "1499", "ignored": false, "role": {"type": "role", "value": "link"}, "chromeRole": {"type": "internalRole", "value": 110}, "name": {"type": "computedString", "value": "Zhang-Sun et\u00a0al., 2015", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "contents", "value": {"type": "computedString", "value": "Zhang-Sun et\u00a0al., 2015"}}, {"type": "attribute", "attribute": "title", "superseded": true}]}, "properties": [{"name": "focusable", "value": {"type": "booleanOrUndefined", "value": true}}], "parentId": "747", "childIds": ["2106"], "backendDOMNodeId": 1842, "browsergym_id": "e36bcfb0-789d-41f9"}, {"nodeId": "1500", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "). The diversity can ultimately result in varied endotoxicity and different ability to induce alpha-syn aggregation.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "). The diversity can ultimately result in varied endotoxicity and different ability to induce alpha-syn aggregation."}}]}, "properties": [], "parentId": "747", "childIds": [], "backendDOMNodeId": 1844}, {"nodeId": "1501", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Using a ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Using a "}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1846}, {"nodeId": "1502", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "748", "childIds": ["2107"], "backendDOMNodeId": 1847, "browsergym_id": "e1700333-23ba-472a"}, {"nodeId": "1503", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " model of PD, we observed that ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " model of PD, we observed that "}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1849}, {"nodeId": "1504", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "748", "childIds": ["2108"], "backendDOMNodeId": 1850, "browsergym_id": "d5e8d931-2f16-4226"}, {"nodeId": "1505", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " bacteria enhanced alpha-syn aggregation in both size and quantity. In addition, we observed that ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " bacteria enhanced alpha-syn aggregation in both size and quantity. In addition, we observed that "}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1852}, {"nodeId": "1506", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "748", "childIds": ["2109"], "backendDOMNodeId": 1853, "browsergym_id": "668264ad-b587-4351"}, {"nodeId": "1507", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " strains isolated from PD patients and healthy individuals had significantly different ability to induce alpha-syn aggregation and toxicity. The results indicate that ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains isolated from PD patients and healthy individuals had significantly different ability to induce alpha-syn aggregation and toxicity. The results indicate that "}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1855}, {"nodeId": "1508", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "748", "childIds": ["2110"], "backendDOMNodeId": 1856, "browsergym_id": "3920d86f-2ebe-49b4"}, {"nodeId": "1509", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " strains have different properties and those bearing particular pathogenic traits play a potential role in PD pathogenesis by inducing or accelerating alpha-syn aggregation. Future studies are necessary to further evaluate the role of these traits in disease development. As ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains have different properties and those bearing particular pathogenic traits play a potential role in PD pathogenesis by inducing or accelerating alpha-syn aggregation. Future studies are necessary to further evaluate the role of these traits in disease development. As "}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1858}, {"nodeId": "1510", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "748", "childIds": ["2111"], "backendDOMNodeId": 1859, "browsergym_id": "82ba1ed3-3361-497b"}, {"nodeId": "1511", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " bacteria are associated with PD and can induce alpha-syn aggregation, eradicating ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " bacteria are associated with PD and can induce alpha-syn aggregation, eradicating "}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1861}, {"nodeId": "1512", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "748", "childIds": ["2112"], "backendDOMNodeId": 1862, "browsergym_id": "6c58d4e4-38cc-47f7"}, {"nodeId": "1513", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " bacteria or keeping their concentration at a low level could be a preventive strategy for PD. ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " bacteria or keeping their concentration at a low level could be a preventive strategy for PD. "}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1864}, {"nodeId": "1514", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "748", "childIds": ["2113"], "backendDOMNodeId": 1865, "browsergym_id": "9cb547e5-e7e3-494d"}, {"nodeId": "1515", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " strains isolated from PD patients and healthy individuals appear to have different traits, but it is not yet known how to differentiate between them except as presented in this study. Therefore, comparative genomics should be performed to identify genetic differences and pathogenic genes from PD patient ", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains isolated from PD patients and healthy individuals appear to have different traits, but it is not yet known how to differentiate between them except as presented in this study. Therefore, comparative genomics should be performed to identify genetic differences and pathogenic genes from PD patient "}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1867}, {"nodeId": "1516", "ignored": false, "role": {"type": "role", "value": "generic"}, "chromeRole": {"type": "internalRole", "value": 88}, "name": {"type": "computedString", "value": "", "sources": [{"type": "relatedElement", "attribute": "aria-labelledby"}, {"type": "attribute", "attribute": "aria-label"}, {"type": "attribute", "attribute": "title"}]}, "properties": [], "parentId": "748", "childIds": ["2114"], "backendDOMNodeId": 1868, "browsergym_id": "7f8e7f9a-4350-4729"}, {"nodeId": "1517", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": " strains.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains."}}]}, "properties": [], "parentId": "748", "childIds": [], "backendDOMNodeId": 1870}, {"nodeId": "1518", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Data availability statement", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Data availability statement"}}]}, "properties": [], "parentId": "750", "childIds": [], "backendDOMNodeId": 1873}, {"nodeId": "1519", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "The original contributions presented in the study are included in the article, further inquiries can be directed to the corresponding author.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "The original contributions presented in the study are included in the article, further inquiries can be directed to the corresponding author."}}]}, "properties": [], "parentId": "751", "childIds": [], "backendDOMNodeId": 1875}, {"nodeId": "1520", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Ethics statement", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Ethics statement"}}]}, "properties": [], "parentId": "753", "childIds": [], "backendDOMNodeId": 1878}, {"nodeId": "1521", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "The studies involving human participants were reviewed and approved by Ethics Committee of Helsinki and the Uusimaa Health District (no. 2510/2020). The patients/participants provided their written informed consent to participate in this study.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "The studies involving human participants were reviewed and approved by Ethics Committee of Helsinki and the Uusimaa Health District (no. 2510/2020). The patients/participants provided their written informed consent to participate in this study."}}]}, "properties": [], "parentId": "754", "childIds": [], "backendDOMNodeId": 1880}, {"nodeId": "1522", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Author contributions", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Author contributions"}}]}, "properties": [], "parentId": "756", "childIds": [], "backendDOMNodeId": 1883}, {"nodeId": "1523", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Conceptualization: VH, TT, KM, PS. Methodology: VH, TT, PS. Investigation: VH, BD. Formal analysis: VH. Resources: KM. Funding acquisition: PS. Project administration: PS. Supervision: VH and PS supervised BD, TT and PS supervised VH. Writing \u2013 original draft: VH. Writing \u2013 review & editing: VH, KM, TT and PS. All authors contributed to the article and approved the submitted version.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Conceptualization: VH, TT, KM, PS. Methodology: VH, TT, PS. Investigation: VH, BD. Formal analysis: VH. Resources: KM. Funding acquisition: PS. Project administration: PS. Supervision: VH and PS supervised BD, TT and PS supervised VH. Writing \u2013 original draft: VH. Writing \u2013 review & editing: VH, KM, TT and PS. All authors contributed to the article and approved the submitted version."}}]}, "properties": [], "parentId": "757", "childIds": [], "backendDOMNodeId": 1885}, {"nodeId": "1524", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Funding", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Funding"}}]}, "properties": [], "parentId": "759", "childIds": [], "backendDOMNodeId": 1888}, {"nodeId": "1525", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "VH acknowledges the financial supports from the Oskar \u00d6flunds Foundation and the University of Helsinki. BD acknowledges the scholarship from the Erasmus Student Exchange Program. This work was supported by the Magnus Ehrnrooth Foundation; and the Jane and Aatos Erkko Foundation.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "VH acknowledges the financial supports from the Oskar \u00d6flunds Foundation and the University of Helsinki. BD acknowledges the scholarship from the Erasmus Student Exchange Program. 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We thank the Light Microscope Unit (University of Helsinki) for the advice and instructions for microscope selection, operation, and image analysis. We thank Leena A. R\u00e4s\u00e4nen and Xiaodan Ouyang (University of Helsinki) for critically reading and giving comments to improve the manuscript. We would like to also thank the Doctoral Programme of Microbiology and Biotechnology (University of Helsinki).", "sources": [{"type": "contents", "value": {"type": "computedString", "value": " strains MC4100 and LSR11. We thank the Light Microscope Unit (University of Helsinki) for the advice and instructions for microscope selection, operation, and image analysis. We thank Leena A. R\u00e4s\u00e4nen and Xiaodan Ouyang (University of Helsinki) for critically reading and giving comments to improve the manuscript. We would like to also thank the Doctoral Programme of Microbiology and Biotechnology (University of Helsinki)."}}]}, "properties": [], "parentId": "763", "childIds": [], "backendDOMNodeId": 1898}, {"nodeId": "1530", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Conflict of interest", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Conflict of interest"}}]}, "properties": [], "parentId": "765", "childIds": [], "backendDOMNodeId": 1901}, {"nodeId": "1531", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."}}]}, "properties": [], "parentId": "766", "childIds": [], "backendDOMNodeId": 1903}, {"nodeId": "1532", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "Publisher\u2019s note", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "Publisher\u2019s note"}}]}, "properties": [], "parentId": "768", "childIds": [], "backendDOMNodeId": 1906}, {"nodeId": "1533", "ignored": false, "role": {"type": "internalRole", "value": "StaticText"}, "chromeRole": {"type": "internalRole", "value": 158}, "name": {"type": "computedString", "value": "All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.", "sources": [{"type": "contents", "value": {"type": "computedString", "value": "All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. 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