Datasets:

aakanksha19

/

cdr_bigbio_processed

like 1

[ { "id": "1", "type": "title", "text": [ "Naloxone reverses the antihypertensive effect of clonidine." ], "offsets": [ [ 0, 59 ] ] }, { "id": "2", "type": "abstract", "text": [ "In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone did not affect either blood pressure or heart rate. In brain membranes from spontaneously hypertensive rats clonidine, 10(-8) to 10(-5) M, did not influence stereoselective binding of [3H]-naloxone (8 nM), and naloxone, 10(-8) to 10(-4) M, did not influence clonidine-suppressible binding of [3H]-dihydroergocryptine (1 nM). These findings indicate that in spontaneously hypertensive rats the effects of central alpha-adrenoceptor stimulation involve activation of opiate receptors. As naloxone and clonidine do not appear to interact with the same receptor site, the observed functional antagonism suggests the release of an endogenous opiate by clonidine or alpha-methyldopa and the possible role of the opiate in the central control of sympathetic tone." ], "offsets": [ [ 60, 1135 ] ] } ]

[ { "id": "3", "type": "Chemical", "text": [ "Naloxone" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009270" } ] }, { "id": "4", "type": "Chemical", "text": [ "clonidine" ], "offsets": [ [ 49, 58 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003000" } ] }, { "id": "5", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 93, 105 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "6", "type": "Chemical", "text": [ "clonidine" ], "offsets": [ [ 181, 190 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003000" } ] }, { "id": "7", "type": "Chemical", "text": [ "nalozone" ], "offsets": [ [ 244, 252 ] ], "normalized": [] }, { "id": "8", "type": "Disease", "text": [ "hypotensive" ], "offsets": [ [ 274, 285 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "9", "type": "Chemical", "text": [ "alpha-methyldopa" ], "offsets": [ [ 306, 322 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008750" } ] }, { "id": "10", "type": "Chemical", "text": [ "naloxone" ], "offsets": [ [ 354, 362 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009270" } ] }, { "id": "11", "type": "Chemical", "text": [ "Naloxone" ], "offsets": [ [ 364, 372 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009270" } ] }, { "id": "12", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 469, 481 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "13", "type": "Chemical", "text": [ "clonidine" ], "offsets": [ [ 487, 496 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003000" } ] }, { "id": "14", "type": "Chemical", "text": [ "[3H]-naloxone" ], "offsets": [ [ 563, 576 ] ], "normalized": [] }, { "id": "15", "type": "Chemical", "text": [ "naloxone" ], "offsets": [ [ 589, 597 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009270" } ] }, { "id": "16", "type": "Chemical", "text": [ "clonidine" ], "offsets": [ [ 637, 646 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003000" } ] }, { "id": "17", "type": "Chemical", "text": [ "[3H]-dihydroergocryptine" ], "offsets": [ [ 671, 695 ] ], "normalized": [] }, { "id": "18", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 750, 762 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "19", "type": "Chemical", "text": [ "naloxone" ], "offsets": [ [ 865, 873 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009270" } ] }, { "id": "20", "type": "Chemical", "text": [ "clonidine" ], "offsets": [ [ 878, 887 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003000" } ] }, { "id": "21", "type": "Chemical", "text": [ "clonidine" ], "offsets": [ [ 1026, 1035 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003000" } ] }, { "id": "22", "type": "Chemical", "text": [ "alpha-methyldopa" ], "offsets": [ [ 1039, 1055 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008750" } ] } ]

[]

[]

[ { "id": "23", "type": "CID", "arg1_id": "9", "arg2_id": "8", "normalized": [] }, { "id": "24", "type": "CID", "arg1_id": "22", "arg2_id": "8", "normalized": [] } ]

[ { "id": "26", "type": "title", "text": [ "Lidocaine-induced cardiac asystole." ], "offsets": [ [ 0, 35 ] ] }, { "id": "27", "type": "abstract", "text": [ "Intravenous administration of a single 50-mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers. The patient had no apparent associated conditions which might have predisposed him to the development of bradyarrhythmias; and, thus, this probably represented a true idiosyncrasy to lidocaine." ], "offsets": [ [ 36, 419 ] ] } ]

[ { "id": "28", "type": "Chemical", "text": [ "Lidocaine" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008012" } ] }, { "id": "29", "type": "Disease", "text": [ "cardiac asystole" ], "offsets": [ [ 18, 34 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006323" } ] }, { "id": "30", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 90, 99 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008012" } ] }, { "id": "31", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 142, 152 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "32", "type": "Disease", "text": [ "bradyarrhythmias" ], "offsets": [ [ 331, 347 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "33", "type": "Chemical", "text": [ "lidocaine" ], "offsets": [ [ 409, 418 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008012" } ] } ]

[]

[]

[ { "id": "34", "type": "CID", "arg1_id": "28", "arg2_id": "29", "normalized": [] }, { "id": "35", "type": "CID", "arg1_id": "30", "arg2_id": "29", "normalized": [] }, { "id": "36", "type": "CID", "arg1_id": "33", "arg2_id": "29", "normalized": [] } ]

[ { "id": "38", "type": "title", "text": [ "Suxamethonium infusion rate and observed fasciculations. A dose-response study." ], "offsets": [ [ 0, 79 ] ] }, { "id": "39", "type": "abstract", "text": [ "Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1. The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when Sch 120 mg was exceeded. Six additional patients received a 30-mg i.v. bolus dose. Fasciculations in six areas of the body were scored from 0 to 3 and summated as a total fasciculation score. The times to first fasciculation, twitch suppression and tetanus suppression were inversely related to the infusion rates. Fasciculations in the six areas and the total fasciculation score were related directly to the rate of infusion. Total fasciculation scores in the 30-mg bolus group and the 5-mg s-1 and 20-mg s-1 infusion groups were not significantly different." ], "offsets": [ [ 80, 872 ] ] } ]

[ { "id": "40", "type": "Chemical", "text": [ "Suxamethonium" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013390" } ] }, { "id": "41", "type": "Disease", "text": [ "fasciculations" ], "offsets": [ [ 41, 55 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005207" } ] }, { "id": "42", "type": "Chemical", "text": [ "Suxamethonium chloride" ], "offsets": [ [ 80, 102 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013390" } ] }, { "id": "43", "type": "Chemical", "text": [ "Sch" ], "offsets": [ [ 104, 107 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013390" } ] }, { "id": "44", "type": "Disease", "text": [ "tetanic" ], "offsets": [ [ 265, 272 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013746" } ] }, { "id": "45", "type": "Chemical", "text": [ "Sch" ], "offsets": [ [ 312, 315 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013390" } ] }, { "id": "46", "type": "Disease", "text": [ "Fasciculations" ], "offsets": [ [ 395, 409 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005207" } ] }, { "id": "47", "type": "Disease", "text": [ "fasciculation" ], "offsets": [ [ 483, 496 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005207" } ] }, { "id": "48", "type": "Disease", "text": [ "fasciculation" ], "offsets": [ [ 523, 536 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005207" } ] }, { "id": "49", "type": "Disease", "text": [ "twitch" ], "offsets": [ [ 538, 544 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013746" } ] }, { "id": "50", "type": "Disease", "text": [ "tetanus" ], "offsets": [ [ 561, 568 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013746" } ] }, { "id": "51", "type": "Disease", "text": [ "Fasciculations" ], "offsets": [ [ 627, 641 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005207" } ] }, { "id": "52", "type": "Disease", "text": [ "fasciculation" ], "offsets": [ [ 673, 686 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005207" } ] }, { "id": "53", "type": "Disease", "text": [ "fasciculation" ], "offsets": [ [ 746, 759 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005207" } ] } ]

[]

[]

[ { "id": "54", "type": "CID", "arg1_id": "40", "arg2_id": "41", "normalized": [] }, { "id": "55", "type": "CID", "arg1_id": "40", "arg2_id": "46", "normalized": [] }, { "id": "56", "type": "CID", "arg1_id": "40", "arg2_id": "47", "normalized": [] }, { "id": "57", "type": "CID", "arg1_id": "40", "arg2_id": "48", "normalized": [] }, { "id": "58", "type": "CID", "arg1_id": "40", "arg2_id": "51", "normalized": [] }, { "id": "59", "type": "CID", "arg1_id": "40", "arg2_id": "52", "normalized": [] }, { "id": "60", "type": "CID", "arg1_id": "40", "arg2_id": "53", "normalized": [] }, { "id": "61", "type": "CID", "arg1_id": "42", "arg2_id": "41", "normalized": [] }, { "id": "62", "type": "CID", "arg1_id": "42", "arg2_id": "46", "normalized": [] }, { "id": "63", "type": "CID", "arg1_id": "42", "arg2_id": "47", "normalized": [] }, { "id": "64", "type": "CID", "arg1_id": "42", "arg2_id": "48", "normalized": [] }, { "id": "65", "type": "CID", "arg1_id": "42", "arg2_id": "51", "normalized": [] }, { "id": "66", "type": "CID", "arg1_id": "42", "arg2_id": "52", "normalized": [] }, { "id": "67", "type": "CID", "arg1_id": "42", "arg2_id": "53", "normalized": [] }, { "id": "68", "type": "CID", "arg1_id": "43", "arg2_id": "41", "normalized": [] }, { "id": "69", "type": "CID", "arg1_id": "43", "arg2_id": "46", "normalized": [] }, { "id": "70", "type": "CID", "arg1_id": "43", "arg2_id": "47", "normalized": [] }, { "id": "71", "type": "CID", "arg1_id": "43", "arg2_id": "48", "normalized": [] }, { "id": "72", "type": "CID", "arg1_id": "43", "arg2_id": "51", "normalized": [] }, { "id": "73", "type": "CID", "arg1_id": "43", "arg2_id": "52", "normalized": [] }, { "id": "74", "type": "CID", "arg1_id": "43", "arg2_id": "53", "normalized": [] }, { "id": "75", "type": "CID", "arg1_id": "45", "arg2_id": "41", "normalized": [] }, { "id": "76", "type": "CID", "arg1_id": "45", "arg2_id": "46", "normalized": [] }, { "id": "77", "type": "CID", "arg1_id": "45", "arg2_id": "47", "normalized": [] }, { "id": "78", "type": "CID", "arg1_id": "45", "arg2_id": "48", "normalized": [] }, { "id": "79", "type": "CID", "arg1_id": "45", "arg2_id": "51", "normalized": [] }, { "id": "80", "type": "CID", "arg1_id": "45", "arg2_id": "52", "normalized": [] }, { "id": "81", "type": "CID", "arg1_id": "45", "arg2_id": "53", "normalized": [] } ]

[ { "id": "83", "type": "title", "text": [ "Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine)." ], "offsets": [ [ 0, 134 ] ] }, { "id": "84", "type": "abstract", "text": [ "Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neuromuscular block. However, studies into the dose necessary to combating scopolamine intoxication are indicated." ], "offsets": [ [ 135, 539 ] ] } ]

[ { "id": "85", "type": "Chemical", "text": [ "Galanthamine hydrobromide" ], "offsets": [ [ 0, 25 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005702" } ] }, { "id": "86", "type": "Chemical", "text": [ "scopolamine" ], "offsets": [ [ 111, 122 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012601" } ] }, { "id": "87", "type": "Chemical", "text": [ "Hyoscine" ], "offsets": [ [ 124, 132 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012601" } ] }, { "id": "88", "type": "Chemical", "text": [ "Galanthamine hydrobromide" ], "offsets": [ [ 135, 160 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005702" } ] }, { "id": "89", "type": "Chemical", "text": [ "scopolamine" ], "offsets": [ [ 292, 303 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012601" } ] }, { "id": "90", "type": "Chemical", "text": [ "hyoscine" ], "offsets": [ [ 305, 313 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012601" } ] }, { "id": "91", "type": "Disease", "text": [ "overdosage" ], "offsets": [ [ 315, 325 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D062787" } ] }, { "id": "92", "type": "Chemical", "text": [ "physostigmine" ], "offsets": [ [ 352, 365 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010830" } ] }, { "id": "93", "type": "Chemical", "text": [ "scopolamine" ], "offsets": [ [ 500, 511 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012601" } ] } ]

[]

[]

[ { "id": "94", "type": "CID", "arg1_id": "86", "arg2_id": "91", "normalized": [] }, { "id": "95", "type": "CID", "arg1_id": "87", "arg2_id": "91", "normalized": [] }, { "id": "96", "type": "CID", "arg1_id": "89", "arg2_id": "91", "normalized": [] }, { "id": "97", "type": "CID", "arg1_id": "90", "arg2_id": "91", "normalized": [] }, { "id": "98", "type": "CID", "arg1_id": "93", "arg2_id": "91", "normalized": [] } ]

[ { "id": "100", "type": "title", "text": [ "Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats." ], "offsets": [ [ 0, 100 ] ] }, { "id": "101", "type": "abstract", "text": [ "Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a lithium-containing diet (50 mmol/kg) for 8 weeks and then randomized to normal diet, HP diet (40 vs. 19%), NX or HP+NX for another 8 weeks. Corresponding non-lithium pretreated groups were generated. When comparing all lithium treated versus non-lithium-treated groups, lithium caused a reduction in glomerular filtration rate (GFR) without significant changes in effective renal plasma flow (as determined by a marker secreted into the proximal tubules) or lithium clearance. Consequently, lithium pretreatment caused a fall in filtration fraction and an increase in fractional Li excretion. Lithium also caused proteinuria and systolic hypertension in absence of glomerulosclerosis. HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma creatinine levels in lithium pretreated rats. NX caused an additive deterioration in GFR which, however, was ameliorated by HP. NX+HP caused a further rise in blood pressure in Li-pretreated rats. The results indicate that Li-induced nephropathy, even when the GFR is only modestly reduced, is associated with proteinuria and arterial systolic hypertension. In this model of chronic renal failure the decline in GFR is not accompanied by a corresponding fall in effective renal plasma flow, which may be the functional expression of the formation of nonfiltrating atubular glomeruli. The fractional reabsorption of tubular fluid by the proximal tubules is reduced, leaving the distal delivery unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)" ], "offsets": [ [ 101, 1892 ] ] } ]

[ { "id": "102", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 54, 61 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "103", "type": "Disease", "text": [ "chronic renal failure" ], "offsets": [ [ 70, 91 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007676" } ] }, { "id": "104", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 111, 118 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "105", "type": "Disease", "text": [ "nephropathy" ], "offsets": [ [ 127, 138 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "106", "type": "Disease", "text": [ "renal failure" ], "offsets": [ [ 309, 322 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "107", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 362, 369 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "108", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 520, 527 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "109", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 581, 588 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "110", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 608, 615 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "111", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 632, 639 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "112", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 820, 827 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "113", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 853, 860 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "114", "type": "Chemical", "text": [ "Li" ], "offsets": [ [ 941, 943 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "115", "type": "Chemical", "text": [ "Lithium" ], "offsets": [ [ 955, 962 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "116", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 975, 986 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "117", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 1000, 1012 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "118", "type": "Disease", "text": [ "glomerulosclerosis" ], "offsets": [ [ 1027, 1045 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005921" } ] }, { "id": "119", "type": "Disease", "text": [ "renal failure" ], "offsets": [ [ 1087, 1100 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "120", "type": "Chemical", "text": [ "creatinine" ], "offsets": [ [ 1156, 1166 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003404" } ] }, { "id": "121", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 1177, 1184 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "122", "type": "Chemical", "text": [ "Li" ], "offsets": [ [ 1333, 1335 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "123", "type": "Chemical", "text": [ "Li" ], "offsets": [ [ 1379, 1381 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "124", "type": "Disease", "text": [ "nephropathy" ], "offsets": [ [ 1390, 1401 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "125", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 1466, 1477 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "126", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 1500, 1512 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "127", "type": "Disease", "text": [ "chronic renal failure" ], "offsets": [ [ 1531, 1552 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007676" } ] } ]

[]

[]

[ { "id": "128", "type": "CID", "arg1_id": "102", "arg2_id": "117", "normalized": [] }, { "id": "129", "type": "CID", "arg1_id": "102", "arg2_id": "126", "normalized": [] }, { "id": "130", "type": "CID", "arg1_id": "104", "arg2_id": "117", "normalized": [] }, { "id": "131", "type": "CID", "arg1_id": "104", "arg2_id": "126", "normalized": [] }, { "id": "132", "type": "CID", "arg1_id": "107", "arg2_id": "117", "normalized": [] }, { "id": "133", "type": "CID", "arg1_id": "107", "arg2_id": "126", "normalized": [] }, { "id": "134", "type": "CID", "arg1_id": "108", "arg2_id": "117", "normalized": [] }, { "id": "135", "type": "CID", "arg1_id": "108", "arg2_id": "126", "normalized": [] }, { "id": "136", "type": "CID", "arg1_id": "109", "arg2_id": "117", "normalized": [] }, { "id": "137", "type": "CID", "arg1_id": "109", "arg2_id": "126", "normalized": [] }, { "id": "138", "type": "CID", "arg1_id": "110", "arg2_id": "117", "normalized": [] }, { "id": "139", "type": "CID", "arg1_id": "110", "arg2_id": "126", "normalized": [] }, { "id": "140", "type": "CID", "arg1_id": "111", "arg2_id": "117", "normalized": [] }, { "id": "141", "type": "CID", "arg1_id": "111", "arg2_id": "126", "normalized": [] }, { "id": "142", "type": "CID", "arg1_id": "112", "arg2_id": "117", "normalized": [] }, { "id": "143", "type": "CID", "arg1_id": "112", "arg2_id": "126", "normalized": [] }, { "id": "144", "type": "CID", "arg1_id": "113", "arg2_id": "117", "normalized": [] }, { "id": "145", "type": "CID", "arg1_id": "113", "arg2_id": "126", "normalized": [] }, { "id": "146", "type": "CID", "arg1_id": "114", "arg2_id": "117", "normalized": [] }, { "id": "147", "type": "CID", "arg1_id": "114", "arg2_id": "126", "normalized": [] }, { "id": "148", "type": "CID", "arg1_id": "115", "arg2_id": "117", "normalized": [] }, { "id": "149", "type": "CID", "arg1_id": "115", "arg2_id": "126", "normalized": [] }, { "id": "150", "type": "CID", "arg1_id": "121", "arg2_id": "117", "normalized": [] }, { "id": "151", "type": "CID", "arg1_id": "121", "arg2_id": "126", "normalized": [] }, { "id": "152", "type": "CID", "arg1_id": "122", "arg2_id": "117", "normalized": [] }, { "id": "153", "type": "CID", "arg1_id": "122", "arg2_id": "126", "normalized": [] }, { "id": "154", "type": "CID", "arg1_id": "123", "arg2_id": "117", "normalized": [] }, { "id": "155", "type": "CID", "arg1_id": "123", "arg2_id": "126", "normalized": [] }, { "id": "156", "type": "CID", "arg1_id": "102", "arg2_id": "116", "normalized": [] }, { "id": "157", "type": "CID", "arg1_id": "102", "arg2_id": "125", "normalized": [] }, { "id": "158", "type": "CID", "arg1_id": "104", "arg2_id": "116", "normalized": [] }, { "id": "159", "type": "CID", "arg1_id": "104", "arg2_id": "125", "normalized": [] }, { "id": "160", "type": "CID", "arg1_id": "107", "arg2_id": "116", "normalized": [] }, { "id": "161", "type": "CID", "arg1_id": "107", "arg2_id": "125", "normalized": [] }, { "id": "162", "type": "CID", "arg1_id": "108", "arg2_id": "116", "normalized": [] }, { "id": "163", "type": "CID", "arg1_id": "108", "arg2_id": "125", "normalized": [] }, { "id": "164", "type": "CID", "arg1_id": "109", "arg2_id": "116", "normalized": [] }, { "id": "165", "type": "CID", "arg1_id": "109", "arg2_id": "125", "normalized": [] }, { "id": "166", "type": "CID", "arg1_id": "110", "arg2_id": "116", "normalized": [] }, { "id": "167", "type": "CID", "arg1_id": "110", "arg2_id": "125", "normalized": [] }, { "id": "168", "type": "CID", "arg1_id": "111", "arg2_id": "116", "normalized": [] }, { "id": "169", "type": "CID", "arg1_id": "111", "arg2_id": "125", "normalized": [] }, { "id": "170", "type": "CID", "arg1_id": "112", "arg2_id": "116", "normalized": [] }, { "id": "171", "type": "CID", "arg1_id": "112", "arg2_id": "125", "normalized": [] }, { "id": "172", "type": "CID", "arg1_id": "113", "arg2_id": "116", "normalized": [] }, { "id": "173", "type": "CID", "arg1_id": "113", "arg2_id": "125", "normalized": [] }, { "id": "174", "type": "CID", "arg1_id": "114", "arg2_id": "116", "normalized": [] }, { "id": "175", "type": "CID", "arg1_id": "114", "arg2_id": "125", "normalized": [] }, { "id": "176", "type": "CID", "arg1_id": "115", "arg2_id": "116", "normalized": [] }, { "id": "177", "type": "CID", "arg1_id": "115", "arg2_id": "125", "normalized": [] }, { "id": "178", "type": "CID", "arg1_id": "121", "arg2_id": "116", "normalized": [] }, { "id": "179", "type": "CID", "arg1_id": "121", "arg2_id": "125", "normalized": [] }, { "id": "180", "type": "CID", "arg1_id": "122", "arg2_id": "116", "normalized": [] }, { "id": "181", "type": "CID", "arg1_id": "122", "arg2_id": "125", "normalized": [] }, { "id": "182", "type": "CID", "arg1_id": "123", "arg2_id": "116", "normalized": [] }, { "id": "183", "type": "CID", "arg1_id": "123", "arg2_id": "125", "normalized": [] }, { "id": "184", "type": "CID", "arg1_id": "102", "arg2_id": "103", "normalized": [] }, { "id": "185", "type": "CID", "arg1_id": "102", "arg2_id": "127", "normalized": [] }, { "id": "186", "type": "CID", "arg1_id": "104", "arg2_id": "103", "normalized": [] }, { "id": "187", "type": "CID", "arg1_id": "104", "arg2_id": "127", "normalized": [] }, { "id": "188", "type": "CID", "arg1_id": "107", "arg2_id": "103", "normalized": [] }, { "id": "189", "type": "CID", "arg1_id": "107", "arg2_id": "127", "normalized": [] }, { "id": "190", "type": "CID", "arg1_id": "108", "arg2_id": "103", "normalized": [] }, { "id": "191", "type": "CID", "arg1_id": "108", "arg2_id": "127", "normalized": [] }, { "id": "192", "type": "CID", "arg1_id": "109", "arg2_id": "103", "normalized": [] }, { "id": "193", "type": "CID", "arg1_id": "109", "arg2_id": "127", "normalized": [] }, { "id": "194", "type": "CID", "arg1_id": "110", "arg2_id": "103", "normalized": [] }, { "id": "195", "type": "CID", "arg1_id": "110", "arg2_id": "127", "normalized": [] }, { "id": "196", "type": "CID", "arg1_id": "111", "arg2_id": "103", "normalized": [] }, { "id": "197", "type": "CID", "arg1_id": "111", "arg2_id": "127", "normalized": [] }, { "id": "198", "type": "CID", "arg1_id": "112", "arg2_id": "103", "normalized": [] }, { "id": "199", "type": "CID", "arg1_id": "112", "arg2_id": "127", "normalized": [] }, { "id": "200", "type": "CID", "arg1_id": "113", "arg2_id": "103", "normalized": [] }, { "id": "201", "type": "CID", "arg1_id": "113", "arg2_id": "127", "normalized": [] }, { "id": "202", "type": "CID", "arg1_id": "114", "arg2_id": "103", "normalized": [] }, { "id": "203", "type": "CID", "arg1_id": "114", "arg2_id": "127", "normalized": [] }, { "id": "204", "type": "CID", "arg1_id": "115", "arg2_id": "103", "normalized": [] }, { "id": "205", "type": "CID", "arg1_id": "115", "arg2_id": "127", "normalized": [] }, { "id": "206", "type": "CID", "arg1_id": "121", "arg2_id": "103", "normalized": [] }, { "id": "207", "type": "CID", "arg1_id": "121", "arg2_id": "127", "normalized": [] }, { "id": "208", "type": "CID", "arg1_id": "122", "arg2_id": "103", "normalized": [] }, { "id": "209", "type": "CID", "arg1_id": "122", "arg2_id": "127", "normalized": [] }, { "id": "210", "type": "CID", "arg1_id": "123", "arg2_id": "103", "normalized": [] }, { "id": "211", "type": "CID", "arg1_id": "123", "arg2_id": "127", "normalized": [] } ]

[ { "id": "213", "type": "title", "text": [ "Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin." ], "offsets": [ [ 0, 119 ] ] }, { "id": "214", "type": "abstract", "text": [ "Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for Crohn's disease, a pilot study was undertaken to estimate the pharmacodynamics and tolerability of fusidic acid treatment in chronic active, therapy-resistant patients. Eight Crohn's disease patients were included. Fusidic acid was administered orally in a dose of 500 mg t.d.s. and the treatment was planned to last 8 weeks. The disease activity was primarily measured by a modified individual grading score. Five of 8 patients (63%) improved during fusidic acid treatment: 3 at two weeks and 2 after four weeks. There were no serious clinical side effects, but dose reduction was required in two patients because of nausea. Biochemically, an increase in alkaline phosphatases was noted in 5 of 8 cases (63%), and the greatest increases were seen in those who had elevated levels prior to treatment. All reversed to pre-treatment levels after cessation of treatment. The results of this pilot study suggest that fusidic acid may be of benefit in selected chronic active Crohn's disease patients in whom conventional treatment is ineffective. Because there seems to exist a scientific rationale for the use of fusidic acid at the cytokine level in inflammatory bowel disease, we suggest that the role of this treatment should be further investigated." ], "offsets": [ [ 120, 1542 ] ] } ]

[ { "id": "215", "type": "Disease", "text": [ "Crohn's disease" ], "offsets": [ [ 13, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003424" } ] }, { "id": "216", "type": "Chemical", "text": [ "fusidic acid" ], "offsets": [ [ 34, 46 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005672" } ] }, { "id": "217", "type": "Chemical", "text": [ "cyclosporin" ], "offsets": [ [ 107, 118 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016572" } ] }, { "id": "218", "type": "Chemical", "text": [ "cyclosporin" ], "offsets": [ [ 217, 228 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016572" } ] }, { "id": "219", "type": "Disease", "text": [ "Crohn's disease" ], "offsets": [ [ 292, 307 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003424" } ] }, { "id": "220", "type": "Chemical", "text": [ "fusidic acid" ], "offsets": [ [ 391, 403 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005672" } ] }, { "id": "221", "type": "Disease", "text": [ "Crohn's disease" ], "offsets": [ [ 467, 482 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003424" } ] }, { "id": "222", "type": "Chemical", "text": [ "Fusidic acid" ], "offsets": [ [ 507, 519 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005672" } ] }, { "id": "223", "type": "Chemical", "text": [ "fusidic acid" ], "offsets": [ [ 743, 755 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005672" } ] }, { "id": "224", "type": "Disease", "text": [ "nausea" ], "offsets": [ [ 910, 916 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009325" } ] }, { "id": "225", "type": "Chemical", "text": [ "fusidic acid" ], "offsets": [ [ 1205, 1217 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005672" } ] }, { "id": "226", "type": "Disease", "text": [ "Crohn's disease" ], "offsets": [ [ 1263, 1278 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003424" } ] }, { "id": "227", "type": "Chemical", "text": [ "fusidic acid" ], "offsets": [ [ 1402, 1414 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005672" } ] }, { "id": "228", "type": "Disease", "text": [ "inflammatory bowel disease" ], "offsets": [ [ 1440, 1466 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015212" } ] } ]

[]

[]

[ { "id": "229", "type": "CID", "arg1_id": "216", "arg2_id": "224", "normalized": [] }, { "id": "230", "type": "CID", "arg1_id": "220", "arg2_id": "224", "normalized": [] }, { "id": "231", "type": "CID", "arg1_id": "222", "arg2_id": "224", "normalized": [] }, { "id": "232", "type": "CID", "arg1_id": "223", "arg2_id": "224", "normalized": [] }, { "id": "233", "type": "CID", "arg1_id": "225", "arg2_id": "224", "normalized": [] }, { "id": "234", "type": "CID", "arg1_id": "227", "arg2_id": "224", "normalized": [] } ]

[ { "id": "236", "type": "title", "text": [ "Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers." ], "offsets": [ [ 0, 99 ] ] }, { "id": "237", "type": "abstract", "text": [ "The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block." ], "offsets": [ [ 100, 391 ] ] } ]

[ { "id": "238", "type": "Disease", "text": [ "myocardial injury" ], "offsets": [ [ 33, 50 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009202" } ] }, { "id": "239", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 83, 90 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "240", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 135, 142 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "241", "type": "Disease", "text": [ "schizophrenic" ], "offsets": [ [ 194, 207 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012559" } ] }, { "id": "242", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 232, 239 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "243", "type": "Disease", "text": [ "myocardial injury" ], "offsets": [ [ 305, 322 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009202" } ] }, { "id": "244", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 334, 355 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "245", "type": "Disease", "text": [ "ischemia" ], "offsets": [ [ 357, 365 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007511" } ] }, { "id": "246", "type": "Disease", "text": [ "bundle branch block" ], "offsets": [ [ 371, 390 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002037" } ] } ]

[]

[]

[ { "id": "247", "type": "CID", "arg1_id": "239", "arg2_id": "244", "normalized": [] }, { "id": "248", "type": "CID", "arg1_id": "240", "arg2_id": "244", "normalized": [] }, { "id": "249", "type": "CID", "arg1_id": "242", "arg2_id": "244", "normalized": [] }, { "id": "250", "type": "CID", "arg1_id": "239", "arg2_id": "246", "normalized": [] }, { "id": "251", "type": "CID", "arg1_id": "240", "arg2_id": "246", "normalized": [] }, { "id": "252", "type": "CID", "arg1_id": "242", "arg2_id": "246", "normalized": [] } ]

[ { "id": "254", "type": "title", "text": [ "Sulpiride-induced tardive dystonia." ], "offsets": [ [ 0, 35 ] ] }, { "id": "255", "type": "abstract", "text": [ "Sulpiride is a selective D2-receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37-year-old man who developed persistent segmental dystonia within 2 months after starting sulpiride therapy. We could not find any previous reports of sulpiride-induced tardive dystonia." ], "offsets": [ [ 36, 491 ] ] } ]

[ { "id": "256", "type": "Chemical", "text": [ "Sulpiride" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013469" } ] }, { "id": "257", "type": "Disease", "text": [ "tardive dystonia" ], "offsets": [ [ 18, 34 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004421" } ] }, { "id": "258", "type": "Chemical", "text": [ "Sulpiride" ], "offsets": [ [ 36, 45 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013469" } ] }, { "id": "259", "type": "Chemical", "text": [ "antidepressant" ], "offsets": [ [ 107, 121 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "260", "type": "Chemical", "text": [ "sulpiride" ], "offsets": [ [ 204, 213 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013469" } ] }, { "id": "261", "type": "Disease", "text": [ "tardive dyskinesia" ], "offsets": [ [ 222, 240 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004409" } ] }, { "id": "262", "type": "Disease", "text": [ "parkinsonism" ], "offsets": [ [ 245, 257 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010302" } ] }, { "id": "263", "type": "Disease", "text": [ "dystonia" ], "offsets": [ [ 355, 363 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004421" } ] }, { "id": "264", "type": "Chemical", "text": [ "sulpiride" ], "offsets": [ [ 395, 404 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013469" } ] }, { "id": "265", "type": "Chemical", "text": [ "sulpiride" ], "offsets": [ [ 456, 465 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013469" } ] }, { "id": "266", "type": "Disease", "text": [ "tardive dystonia" ], "offsets": [ [ 474, 490 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004421" } ] } ]

[]

[]

[ { "id": "267", "type": "CID", "arg1_id": "256", "arg2_id": "257", "normalized": [] }, { "id": "268", "type": "CID", "arg1_id": "256", "arg2_id": "263", "normalized": [] }, { "id": "269", "type": "CID", "arg1_id": "256", "arg2_id": "266", "normalized": [] }, { "id": "270", "type": "CID", "arg1_id": "258", "arg2_id": "257", "normalized": [] }, { "id": "271", "type": "CID", "arg1_id": "258", "arg2_id": "263", "normalized": [] }, { "id": "272", "type": "CID", "arg1_id": "258", "arg2_id": "266", "normalized": [] }, { "id": "273", "type": "CID", "arg1_id": "260", "arg2_id": "257", "normalized": [] }, { "id": "274", "type": "CID", "arg1_id": "260", "arg2_id": "263", "normalized": [] }, { "id": "275", "type": "CID", "arg1_id": "260", "arg2_id": "266", "normalized": [] }, { "id": "276", "type": "CID", "arg1_id": "264", "arg2_id": "257", "normalized": [] }, { "id": "277", "type": "CID", "arg1_id": "264", "arg2_id": "263", "normalized": [] }, { "id": "278", "type": "CID", "arg1_id": "264", "arg2_id": "266", "normalized": [] }, { "id": "279", "type": "CID", "arg1_id": "265", "arg2_id": "257", "normalized": [] }, { "id": "280", "type": "CID", "arg1_id": "265", "arg2_id": "263", "normalized": [] }, { "id": "281", "type": "CID", "arg1_id": "265", "arg2_id": "266", "normalized": [] } ]

[ { "id": "283", "type": "title", "text": [ "Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine." ], "offsets": [ [ 0, 80 ] ] }, { "id": "284", "type": "abstract", "text": [ "During an 18-month period of study 41 hemodialyzed patients receiving desferrioxamine (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies disclosed abnormalities in 7 more asymptomatic patients. Visual toxicity was of retinal origin and was characterized by a tritan-type dyschromatopsy, sometimes associated with a loss of visual acuity and pigmentary retinal deposits. Auditory toxicity was characterized by a mid- to high-frequency neurosensorial hearing loss and the lesion was of the cochlear type. Desferrioxamine withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3, and a complete reversal of hearing loss in 3 patients and partial recovery in 3. This toxicity appeared in patients receiving the higher doses of desferrioxamine or coincided with the normalization of ferritin or aluminium serum levels. The data indicate that audiovisual toxicity is not an infrequent complication in hemodialyzed patients receiving desferrioxamine. Periodical audiovisual monitoring should be performed on hemodialyzed patients receiving the drug in order to detect adverse effects as early as possible." ], "offsets": [ [ 81, 1405 ] ] } ]

[ { "id": "285", "type": "Disease", "text": [ "Ocular and auditory toxicity" ], "offsets": [ [ 0, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" }, { "db_name": "MESH", "db_id": "D006311" } ] }, { "id": "286", "type": "Disease", "text": [ "Ocular", "toxicity" ], "offsets": [ [ 0, 6 ], [ 20, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" } ] }, { "id": "287", "type": "Disease", "text": [ "auditory toxicity" ], "offsets": [ [ 11, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006311" } ] }, { "id": "288", "type": "Chemical", "text": [ "desferrioxamine" ], "offsets": [ [ 64, 79 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003676" } ] }, { "id": "289", "type": "Chemical", "text": [ "desferrioxamine" ], "offsets": [ [ 151, 166 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003676" } ] }, { "id": "290", "type": "Disease", "text": [ "audiovisual toxicity" ], "offsets": [ [ 250, 270 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" }, { "db_name": "MESH", "db_id": "D006311" } ] }, { "id": "291", "type": "Disease", "text": [ "visual or auditory toxicity" ], "offsets": [ [ 314, 341 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" }, { "db_name": "MESH", "db_id": "D006311" } ] }, { "id": "292", "type": "Disease", "text": [ "visual", "toxicity" ], "offsets": [ [ 314, 320 ], [ 333, 341 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" } ] }, { "id": "293", "type": "Disease", "text": [ "auditory toxicity" ], "offsets": [ [ 324, 341 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006311" } ] }, { "id": "294", "type": "Disease", "text": [ "Visual toxicity" ], "offsets": [ [ 457, 472 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" } ] }, { "id": "295", "type": "Disease", "text": [ "dyschromatopsy" ], "offsets": [ [ 534, 548 ] ], "normalized": [] }, { "id": "296", "type": "Disease", "text": [ "a loss of visual acuity" ], "offsets": [ [ 576, 599 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" } ] }, { "id": "297", "type": "Disease", "text": [ "pigmentary retinal deposits" ], "offsets": [ [ 604, 631 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012164" } ] }, { "id": "298", "type": "Disease", "text": [ "Auditory toxicity" ], "offsets": [ [ 633, 650 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006311" } ] }, { "id": "299", "type": "Disease", "text": [ "neurosensorial hearing loss" ], "offsets": [ [ 697, 724 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006319" } ] }, { "id": "300", "type": "Chemical", "text": [ "Desferrioxamine" ], "offsets": [ [ 766, 781 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003676" } ] }, { "id": "301", "type": "Disease", "text": [ "hearing loss" ], "offsets": [ [ 911, 923 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D034381" } ] }, { "id": "302", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 970, 978 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "303", "type": "Chemical", "text": [ "desferrioxamine" ], "offsets": [ [ 1030, 1045 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003676" } ] }, { "id": "304", "type": "Chemical", "text": [ "aluminium" ], "offsets": [ [ 1097, 1106 ] ], "normalized": [] }, { "id": "305", "type": "Disease", "text": [ "audiovisual toxicity" ], "offsets": [ [ 1144, 1164 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" }, { "db_name": "MESH", "db_id": "D006311" } ] }, { "id": "306", "type": "Chemical", "text": [ "desferrioxamine" ], "offsets": [ [ 1234, 1249 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003676" } ] } ]

[]

[]

[ { "id": "307", "type": "CID", "arg1_id": "288", "arg2_id": "297", "normalized": [] }, { "id": "308", "type": "CID", "arg1_id": "289", "arg2_id": "297", "normalized": [] }, { "id": "309", "type": "CID", "arg1_id": "300", "arg2_id": "297", "normalized": [] }, { "id": "310", "type": "CID", "arg1_id": "303", "arg2_id": "297", "normalized": [] }, { "id": "311", "type": "CID", "arg1_id": "306", "arg2_id": "297", "normalized": [] }, { "id": "312", "type": "CID", "arg1_id": "288", "arg2_id": "285", "normalized": [] }, { "id": "313", "type": "CID", "arg1_id": "288", "arg2_id": "286", "normalized": [] }, { "id": "314", "type": "CID", "arg1_id": "288", "arg2_id": "290", "normalized": [] }, { "id": "315", "type": "CID", "arg1_id": "288", "arg2_id": "291", "normalized": [] }, { "id": "316", "type": "CID", "arg1_id": "288", "arg2_id": "292", "normalized": [] }, { "id": "317", "type": "CID", "arg1_id": "288", "arg2_id": "294", "normalized": [] }, { "id": "318", "type": "CID", "arg1_id": "288", "arg2_id": "296", "normalized": [] }, { "id": "319", "type": "CID", "arg1_id": "288", "arg2_id": "305", "normalized": [] }, { "id": "320", "type": "CID", "arg1_id": "289", "arg2_id": "285", "normalized": [] }, { "id": "321", "type": "CID", "arg1_id": "289", "arg2_id": "286", "normalized": [] }, { "id": "322", "type": "CID", "arg1_id": "289", "arg2_id": "290", "normalized": [] }, { "id": "323", "type": "CID", "arg1_id": "289", "arg2_id": "291", "normalized": [] }, { "id": "324", "type": "CID", "arg1_id": "289", "arg2_id": "292", "normalized": [] }, { "id": "325", "type": "CID", "arg1_id": "289", "arg2_id": "294", "normalized": [] }, { "id": "326", "type": "CID", "arg1_id": "289", "arg2_id": "296", "normalized": [] }, { "id": "327", "type": "CID", "arg1_id": "289", "arg2_id": "305", "normalized": [] }, { "id": "328", "type": "CID", "arg1_id": "300", "arg2_id": "285", "normalized": [] }, { "id": "329", "type": "CID", "arg1_id": "300", "arg2_id": "286", "normalized": [] }, { "id": "330", "type": "CID", "arg1_id": "300", "arg2_id": "290", "normalized": [] }, { "id": "331", "type": "CID", "arg1_id": "300", "arg2_id": "291", "normalized": [] }, { "id": "332", "type": "CID", "arg1_id": "300", "arg2_id": "292", "normalized": [] }, { "id": "333", "type": "CID", "arg1_id": "300", "arg2_id": "294", "normalized": [] }, { "id": "334", "type": "CID", "arg1_id": "300", "arg2_id": "296", "normalized": [] }, { "id": "335", "type": "CID", "arg1_id": "300", "arg2_id": "305", "normalized": [] }, { "id": "336", "type": "CID", "arg1_id": "303", "arg2_id": "285", "normalized": [] }, { "id": "337", "type": "CID", "arg1_id": "303", "arg2_id": "286", "normalized": [] }, { "id": "338", "type": "CID", "arg1_id": "303", "arg2_id": "290", "normalized": [] }, { "id": "339", "type": "CID", "arg1_id": "303", "arg2_id": "291", "normalized": [] }, { "id": "340", "type": "CID", "arg1_id": "303", "arg2_id": "292", "normalized": [] }, { "id": "341", "type": "CID", "arg1_id": "303", "arg2_id": "294", "normalized": [] }, { "id": "342", "type": "CID", "arg1_id": "303", "arg2_id": "296", "normalized": [] }, { "id": "343", "type": "CID", "arg1_id": "303", "arg2_id": "305", "normalized": [] }, { "id": "344", "type": "CID", "arg1_id": "306", "arg2_id": "285", "normalized": [] }, { "id": "345", "type": "CID", "arg1_id": "306", "arg2_id": "286", "normalized": [] }, { "id": "346", "type": "CID", "arg1_id": "306", "arg2_id": "290", "normalized": [] }, { "id": "347", "type": "CID", "arg1_id": "306", "arg2_id": "291", "normalized": [] }, { "id": "348", "type": "CID", "arg1_id": "306", "arg2_id": "292", "normalized": [] }, { "id": "349", "type": "CID", "arg1_id": "306", "arg2_id": "294", "normalized": [] }, { "id": "350", "type": "CID", "arg1_id": "306", "arg2_id": "296", "normalized": [] }, { "id": "351", "type": "CID", "arg1_id": "306", "arg2_id": "305", "normalized": [] }, { "id": "352", "type": "CID", "arg1_id": "288", "arg2_id": "299", "normalized": [] }, { "id": "353", "type": "CID", "arg1_id": "289", "arg2_id": "299", "normalized": [] }, { "id": "354", "type": "CID", "arg1_id": "300", "arg2_id": "299", "normalized": [] }, { "id": "355", "type": "CID", "arg1_id": "303", "arg2_id": "299", "normalized": [] }, { "id": "356", "type": "CID", "arg1_id": "306", "arg2_id": "299", "normalized": [] } ]

[ { "id": "358", "type": "title", "text": [ "Myasthenia gravis presenting as weakness after magnesium administration." ], "offsets": [ [ 0, 72 ] ] }, { "id": "359", "type": "abstract", "text": [ "We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3.0 mEq/L, which is usually well tolerated. The magnesium was stopped and she recovered over a few days. While she was weak, 2-Hz repetitive stimulation revealed a decrement without significant facilitation at rapid rates or after exercise, suggesting postsynaptic neuromuscular blockade. After her strength returned, repetitive stimulation was normal, but single fiber EMG revealed increased jitter and blocking. Her acetylcholine receptor antibody level was markedly elevated. Although paralysis after magnesium administration has been described in patients with known myasthenia gravis, it has not previously been reported to be the initial or only manifestation of the disease. Patients who are unusually sensitive to the neuromuscular effects of magnesium should be suspected of having an underlying disorder of neuromuscular transmission." ], "offsets": [ [ 73, 1117 ] ] } ]

[ { "id": "360", "type": "Disease", "text": [ "Myasthenia gravis" ], "offsets": [ [ 0, 17 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009157" } ] }, { "id": "361", "type": "Chemical", "text": [ "magnesium" ], "offsets": [ [ 47, 56 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008274" } ] }, { "id": "362", "type": "Disease", "text": [ "neuromuscular disease" ], "offsets": [ [ 119, 140 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009468" } ] }, { "id": "363", "type": "Disease", "text": [ "quadriplegic" ], "offsets": [ [ 162, 174 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011782" } ] }, { "id": "364", "type": "Chemical", "text": [ "magnesium" ], "offsets": [ [ 192, 201 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008274" } ] }, { "id": "365", "type": "Disease", "text": [ "preeclampsia" ], "offsets": [ [ 221, 233 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011225" } ] }, { "id": "366", "type": "Chemical", "text": [ "magnesium" ], "offsets": [ [ 245, 254 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008274" } ] }, { "id": "367", "type": "Chemical", "text": [ "magnesium" ], "offsets": [ [ 321, 330 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008274" } ] }, { "id": "368", "type": "Disease", "text": [ "postsynaptic neuromuscular blockade" ], "offsets": [ [ 525, 560 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009468" } ] }, { "id": "369", "type": "Chemical", "text": [ "acetylcholine" ], "offsets": [ [ 691, 704 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000109" } ] }, { "id": "370", "type": "Disease", "text": [ "paralysis" ], "offsets": [ [ 761, 770 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010243" } ] }, { "id": "371", "type": "Chemical", "text": [ "magnesium" ], "offsets": [ [ 777, 786 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008274" } ] }, { "id": "372", "type": "Disease", "text": [ "myasthenia gravis" ], "offsets": [ [ 844, 861 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009157" } ] }, { "id": "373", "type": "Chemical", "text": [ "magnesium" ], "offsets": [ [ 1024, 1033 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008274" } ] }, { "id": "374", "type": "Disease", "text": [ "disorder of neuromuscular transmission" ], "offsets": [ [ 1078, 1116 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020511" } ] } ]

[]

[]

[ { "id": "375", "type": "CID", "arg1_id": "361", "arg2_id": "360", "normalized": [] }, { "id": "376", "type": "CID", "arg1_id": "361", "arg2_id": "372", "normalized": [] }, { "id": "377", "type": "CID", "arg1_id": "364", "arg2_id": "360", "normalized": [] }, { "id": "378", "type": "CID", "arg1_id": "364", "arg2_id": "372", "normalized": [] }, { "id": "379", "type": "CID", "arg1_id": "366", "arg2_id": "360", "normalized": [] }, { "id": "380", "type": "CID", "arg1_id": "366", "arg2_id": "372", "normalized": [] }, { "id": "381", "type": "CID", "arg1_id": "367", "arg2_id": "360", "normalized": [] }, { "id": "382", "type": "CID", "arg1_id": "367", "arg2_id": "372", "normalized": [] }, { "id": "383", "type": "CID", "arg1_id": "371", "arg2_id": "360", "normalized": [] }, { "id": "384", "type": "CID", "arg1_id": "371", "arg2_id": "372", "normalized": [] }, { "id": "385", "type": "CID", "arg1_id": "373", "arg2_id": "360", "normalized": [] }, { "id": "386", "type": "CID", "arg1_id": "373", "arg2_id": "372", "normalized": [] } ]

[ { "id": "388", "type": "title", "text": [ "Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication." ], "offsets": [ [ 0, 151 ] ] }, { "id": "389", "type": "abstract", "text": [ "Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administration does not contribute to bladder damage. When instilled directly into the bladder, CAA exerts urotoxic effects, it is, however, susceptible to detoxification with mesna." ], "offsets": [ [ 152, 620 ] ] } ]

[ { "id": "390", "type": "Chemical", "text": [ "Chloroacetaldehyde" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C004656" } ] }, { "id": "391", "type": "Chemical", "text": [ "cyclophosphamide" ], "offsets": [ [ 77, 93 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003520" } ] }, { "id": "392", "type": "Chemical", "text": [ "ifosfamide" ], "offsets": [ [ 97, 107 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007069" } ] }, { "id": "393", "type": "Chemical", "text": [ "chloroacetaldehyde" ], "offsets": [ [ 192, 210 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C004656" } ] }, { "id": "394", "type": "Chemical", "text": [ "CAA" ], "offsets": [ [ 212, 215 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C004656" } ] }, { "id": "395", "type": "Chemical", "text": [ "CAA" ], "offsets": [ [ 349, 352 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C004656" } ] }, { "id": "396", "type": "Disease", "text": [ "hemorrhagic cystitis" ], "offsets": [ [ 375, 395 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006470" }, { "db_name": "MESH", "db_id": "D003556" } ] }, { "id": "397", "type": "Disease", "text": [ "hemorrhagic" ], "offsets": [ [ 375, 386 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006470" } ] }, { "id": "398", "type": "Disease", "text": [ "cystitis" ], "offsets": [ [ 387, 395 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003556" } ] }, { "id": "399", "type": "Chemical", "text": [ "CAA" ], "offsets": [ [ 423, 426 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C004656" } ] }, { "id": "400", "type": "Disease", "text": [ "bladder damage" ], "offsets": [ [ 476, 490 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001745" } ] }, { "id": "401", "type": "Chemical", "text": [ "CAA" ], "offsets": [ [ 534, 537 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C004656" } ] }, { "id": "402", "type": "Chemical", "text": [ "mesna" ], "offsets": [ [ 614, 619 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015080" } ] } ]

[]

[]

[ { "id": "403", "type": "CID", "arg1_id": "390", "arg2_id": "396", "normalized": [] }, { "id": "404", "type": "CID", "arg1_id": "390", "arg2_id": "398", "normalized": [] }, { "id": "405", "type": "CID", "arg1_id": "393", "arg2_id": "396", "normalized": [] }, { "id": "406", "type": "CID", "arg1_id": "393", "arg2_id": "398", "normalized": [] }, { "id": "407", "type": "CID", "arg1_id": "394", "arg2_id": "396", "normalized": [] }, { "id": "408", "type": "CID", "arg1_id": "394", "arg2_id": "398", "normalized": [] }, { "id": "409", "type": "CID", "arg1_id": "395", "arg2_id": "396", "normalized": [] }, { "id": "410", "type": "CID", "arg1_id": "395", "arg2_id": "398", "normalized": [] }, { "id": "411", "type": "CID", "arg1_id": "399", "arg2_id": "396", "normalized": [] }, { "id": "412", "type": "CID", "arg1_id": "399", "arg2_id": "398", "normalized": [] }, { "id": "413", "type": "CID", "arg1_id": "401", "arg2_id": "396", "normalized": [] }, { "id": "414", "type": "CID", "arg1_id": "401", "arg2_id": "398", "normalized": [] }, { "id": "415", "type": "CID", "arg1_id": "390", "arg2_id": "396", "normalized": [] }, { "id": "416", "type": "CID", "arg1_id": "390", "arg2_id": "397", "normalized": [] }, { "id": "417", "type": "CID", "arg1_id": "393", "arg2_id": "396", "normalized": [] }, { "id": "418", "type": "CID", "arg1_id": "393", "arg2_id": "397", "normalized": [] }, { "id": "419", "type": "CID", "arg1_id": "394", "arg2_id": "396", "normalized": [] }, { "id": "420", "type": "CID", "arg1_id": "394", "arg2_id": "397", "normalized": [] }, { "id": "421", "type": "CID", "arg1_id": "395", "arg2_id": "396", "normalized": [] }, { "id": "422", "type": "CID", "arg1_id": "395", "arg2_id": "397", "normalized": [] }, { "id": "423", "type": "CID", "arg1_id": "399", "arg2_id": "396", "normalized": [] }, { "id": "424", "type": "CID", "arg1_id": "399", "arg2_id": "397", "normalized": [] }, { "id": "425", "type": "CID", "arg1_id": "401", "arg2_id": "396", "normalized": [] }, { "id": "426", "type": "CID", "arg1_id": "401", "arg2_id": "397", "normalized": [] } ]

[ { "id": "428", "type": "title", "text": [ "Source of pain and primitive dysfunction in migraine: an identical site?" ], "offsets": [ [ 0, 72 ] ] }, { "id": "429", "type": "abstract", "text": [ "Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 migraine patients, who developed an early onset attack with frontotemporal nitroglycerin, received the drug in a second induction test at other body areas. No early onset migraine was observed. Thus the migraine-inducing effect of nitroglycerin seems to depend on direct stimulation of the habitual site of pain, suggesting that the frontotemporal region is of crucial importance in the development of a migraine crisis. This is not consistent with a CNS origin of migraine attack." ], "offsets": [ [ 73, 867 ] ] } ]

[ { "id": "430", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 10, 14 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010146" } ] }, { "id": "431", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 44, 52 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "432", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 87, 95 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "433", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 156, 169 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "434", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 255, 263 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "435", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 288, 301 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "436", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 386, 394 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "437", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 461, 474 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "438", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 557, 565 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "439", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 589, 597 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "440", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 617, 630 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "441", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 693, 697 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010146" } ] }, { "id": "442", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 790, 798 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "443", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 851, 859 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] } ]

[]

[]

[ { "id": "444", "type": "CID", "arg1_id": "433", "arg2_id": "431", "normalized": [] }, { "id": "445", "type": "CID", "arg1_id": "433", "arg2_id": "432", "normalized": [] }, { "id": "446", "type": "CID", "arg1_id": "433", "arg2_id": "434", "normalized": [] }, { "id": "447", "type": "CID", "arg1_id": "433", "arg2_id": "436", "normalized": [] }, { "id": "448", "type": "CID", "arg1_id": "433", "arg2_id": "438", "normalized": [] }, { "id": "449", "type": "CID", "arg1_id": "433", "arg2_id": "439", "normalized": [] }, { "id": "450", "type": "CID", "arg1_id": "433", "arg2_id": "442", "normalized": [] }, { "id": "451", "type": "CID", "arg1_id": "433", "arg2_id": "443", "normalized": [] }, { "id": "452", "type": "CID", "arg1_id": "435", "arg2_id": "431", "normalized": [] }, { "id": "453", "type": "CID", "arg1_id": "435", "arg2_id": "432", "normalized": [] }, { "id": "454", "type": "CID", "arg1_id": "435", "arg2_id": "434", "normalized": [] }, { "id": "455", "type": "CID", "arg1_id": "435", "arg2_id": "436", "normalized": [] }, { "id": "456", "type": "CID", "arg1_id": "435", "arg2_id": "438", "normalized": [] }, { "id": "457", "type": "CID", "arg1_id": "435", "arg2_id": "439", "normalized": [] }, { "id": "458", "type": "CID", "arg1_id": "435", "arg2_id": "442", "normalized": [] }, { "id": "459", "type": "CID", "arg1_id": "435", "arg2_id": "443", "normalized": [] }, { "id": "460", "type": "CID", "arg1_id": "437", "arg2_id": "431", "normalized": [] }, { "id": "461", "type": "CID", "arg1_id": "437", "arg2_id": "432", "normalized": [] }, { "id": "462", "type": "CID", "arg1_id": "437", "arg2_id": "434", "normalized": [] }, { "id": "463", "type": "CID", "arg1_id": "437", "arg2_id": "436", "normalized": [] }, { "id": "464", "type": "CID", "arg1_id": "437", "arg2_id": "438", "normalized": [] }, { "id": "465", "type": "CID", "arg1_id": "437", "arg2_id": "439", "normalized": [] }, { "id": "466", "type": "CID", "arg1_id": "437", "arg2_id": "442", "normalized": [] }, { "id": "467", "type": "CID", "arg1_id": "437", "arg2_id": "443", "normalized": [] }, { "id": "468", "type": "CID", "arg1_id": "440", "arg2_id": "431", "normalized": [] }, { "id": "469", "type": "CID", "arg1_id": "440", "arg2_id": "432", "normalized": [] }, { "id": "470", "type": "CID", "arg1_id": "440", "arg2_id": "434", "normalized": [] }, { "id": "471", "type": "CID", "arg1_id": "440", "arg2_id": "436", "normalized": [] }, { "id": "472", "type": "CID", "arg1_id": "440", "arg2_id": "438", "normalized": [] }, { "id": "473", "type": "CID", "arg1_id": "440", "arg2_id": "439", "normalized": [] }, { "id": "474", "type": "CID", "arg1_id": "440", "arg2_id": "442", "normalized": [] }, { "id": "475", "type": "CID", "arg1_id": "440", "arg2_id": "443", "normalized": [] } ]

[ { "id": "477", "type": "title", "text": [ "Clotiazepam-induced acute hepatitis." ], "offsets": [ [ 0, 36 ] ] }, { "id": "478", "type": "abstract", "text": [ "We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration of several benzodiazepines, chemically related to clotiazepam, did not interfere with recovery and did not induce any relapse of hepatitis. This observation shows that clotiazepam can induce acute hepatitis and suggests that there is no cross hepatotoxicity between clotiazepam and several benzodiazepines." ], "offsets": [ [ 37, 609 ] ] } ]

[ { "id": "479", "type": "Chemical", "text": [ "Clotiazepam" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C084599" } ] }, { "id": "480", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 26, 35 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "481", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 89, 98 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "482", "type": "Disease", "text": [ "extensive hepatocellular necrosis" ], "offsets": [ [ 104, 137 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D047508" } ] }, { "id": "483", "type": "Chemical", "text": [ "clotiazepam" ], "offsets": [ [ 185, 196 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C084599" } ] }, { "id": "484", "type": "Chemical", "text": [ "thienodiazepine" ], "offsets": [ [ 200, 215 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C013295" } ] }, { "id": "485", "type": "Chemical", "text": [ "Clotiazepam" ], "offsets": [ [ 228, 239 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C084599" } ] }, { "id": "486", "type": "Chemical", "text": [ "benzodiazepines" ], "offsets": [ [ 314, 329 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "487", "type": "Chemical", "text": [ "clotiazepam" ], "offsets": [ [ 353, 364 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C084599" } ] }, { "id": "488", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 432, 441 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "489", "type": "Chemical", "text": [ "clotiazepam" ], "offsets": [ [ 471, 482 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C084599" } ] }, { "id": "490", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 500, 509 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "491", "type": "Disease", "text": [ "hepatotoxicity" ], "offsets": [ [ 546, 560 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "492", "type": "Chemical", "text": [ "clotiazepam" ], "offsets": [ [ 569, 580 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C084599" } ] }, { "id": "493", "type": "Chemical", "text": [ "benzodiazepines" ], "offsets": [ [ 593, 608 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] } ]

[]

[]

[ { "id": "494", "type": "CID", "arg1_id": "479", "arg2_id": "480", "normalized": [] }, { "id": "495", "type": "CID", "arg1_id": "479", "arg2_id": "481", "normalized": [] }, { "id": "496", "type": "CID", "arg1_id": "479", "arg2_id": "488", "normalized": [] }, { "id": "497", "type": "CID", "arg1_id": "479", "arg2_id": "490", "normalized": [] }, { "id": "498", "type": "CID", "arg1_id": "479", "arg2_id": "491", "normalized": [] }, { "id": "499", "type": "CID", "arg1_id": "483", "arg2_id": "480", "normalized": [] }, { "id": "500", "type": "CID", "arg1_id": "483", "arg2_id": "481", "normalized": [] }, { "id": "501", "type": "CID", "arg1_id": "483", "arg2_id": "488", "normalized": [] }, { "id": "502", "type": "CID", "arg1_id": "483", "arg2_id": "490", "normalized": [] }, { "id": "503", "type": "CID", "arg1_id": "483", "arg2_id": "491", "normalized": [] }, { "id": "504", "type": "CID", "arg1_id": "485", "arg2_id": "480", "normalized": [] }, { "id": "505", "type": "CID", "arg1_id": "485", "arg2_id": "481", "normalized": [] }, { "id": "506", "type": "CID", "arg1_id": "485", "arg2_id": "488", "normalized": [] }, { "id": "507", "type": "CID", "arg1_id": "485", "arg2_id": "490", "normalized": [] }, { "id": "508", "type": "CID", "arg1_id": "485", "arg2_id": "491", "normalized": [] }, { "id": "509", "type": "CID", "arg1_id": "487", "arg2_id": "480", "normalized": [] }, { "id": "510", "type": "CID", "arg1_id": "487", "arg2_id": "481", "normalized": [] }, { "id": "511", "type": "CID", "arg1_id": "487", "arg2_id": "488", "normalized": [] }, { "id": "512", "type": "CID", "arg1_id": "487", "arg2_id": "490", "normalized": [] }, { "id": "513", "type": "CID", "arg1_id": "487", "arg2_id": "491", "normalized": [] }, { "id": "514", "type": "CID", "arg1_id": "489", "arg2_id": "480", "normalized": [] }, { "id": "515", "type": "CID", "arg1_id": "489", "arg2_id": "481", "normalized": [] }, { "id": "516", "type": "CID", "arg1_id": "489", "arg2_id": "488", "normalized": [] }, { "id": "517", "type": "CID", "arg1_id": "489", "arg2_id": "490", "normalized": [] }, { "id": "518", "type": "CID", "arg1_id": "489", "arg2_id": "491", "normalized": [] }, { "id": "519", "type": "CID", "arg1_id": "492", "arg2_id": "480", "normalized": [] }, { "id": "520", "type": "CID", "arg1_id": "492", "arg2_id": "481", "normalized": [] }, { "id": "521", "type": "CID", "arg1_id": "492", "arg2_id": "488", "normalized": [] }, { "id": "522", "type": "CID", "arg1_id": "492", "arg2_id": "490", "normalized": [] }, { "id": "523", "type": "CID", "arg1_id": "492", "arg2_id": "491", "normalized": [] } ]

[ { "id": "525", "type": "title", "text": [ "Arterial hypertension as a complication of prolonged ketoconazole treatment." ], "offsets": [ [ 0, 76 ] ] }, { "id": "526", "type": "abstract", "text": [ "Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet continuous blood pressure monitoring demonstrated hypertension 31 (patient 1) and 52 weeks (patient 2) after treatment. In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated. In patient 2, in addition to an increase in both deoxycorticosterone and 11-deoxycortisol levels, plasma aldosterone values were raised, with a concomitant suppression of renin levels. Our findings show that long-term treatment with high doses of ketoconazole may induce enzyme blockade leading to mineralocorticoid-related hypertension." ], "offsets": [ [ 77, 860 ] ] } ]

[ { "id": "527", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 9, 21 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "528", "type": "Chemical", "text": [ "ketoconazole" ], "offsets": [ [ 53, 65 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007654" } ] }, { "id": "529", "type": "Disease", "text": [ "Cushing's syndrome" ], "offsets": [ [ 101, 119 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003480" } ] }, { "id": "530", "type": "Chemical", "text": [ "ketoconazole" ], "offsets": [ [ 154, 166 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007654" } ] }, { "id": "531", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 187, 199 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "532", "type": "Chemical", "text": [ "cortisol" ], "offsets": [ [ 246, 254 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006854" } ] }, { "id": "533", "type": "Chemical", "text": [ "ketoconazole" ], "offsets": [ [ 290, 302 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007654" } ] }, { "id": "534", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 366, 378 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "535", "type": "Chemical", "text": [ "deoxycorticosterone" ], "offsets": [ [ 467, 486 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003900" } ] }, { "id": "536", "type": "Chemical", "text": [ "11-deoxycortisol" ], "offsets": [ [ 491, 507 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003350" } ] }, { "id": "537", "type": "Chemical", "text": [ "deoxycorticosterone" ], "offsets": [ [ 572, 591 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003900" } ] }, { "id": "538", "type": "Chemical", "text": [ "11-deoxycortisol" ], "offsets": [ [ 596, 612 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003350" } ] }, { "id": "539", "type": "Chemical", "text": [ "aldosterone" ], "offsets": [ [ 628, 639 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000450" } ] }, { "id": "540", "type": "Chemical", "text": [ "ketoconazole" ], "offsets": [ [ 770, 782 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007654" } ] }, { "id": "541", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 847, 859 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] } ]

[]

[]

[ { "id": "542", "type": "CID", "arg1_id": "528", "arg2_id": "527", "normalized": [] }, { "id": "543", "type": "CID", "arg1_id": "528", "arg2_id": "531", "normalized": [] }, { "id": "544", "type": "CID", "arg1_id": "528", "arg2_id": "534", "normalized": [] }, { "id": "545", "type": "CID", "arg1_id": "528", "arg2_id": "541", "normalized": [] }, { "id": "546", "type": "CID", "arg1_id": "530", "arg2_id": "527", "normalized": [] }, { "id": "547", "type": "CID", "arg1_id": "530", "arg2_id": "531", "normalized": [] }, { "id": "548", "type": "CID", "arg1_id": "530", "arg2_id": "534", "normalized": [] }, { "id": "549", "type": "CID", "arg1_id": "530", "arg2_id": "541", "normalized": [] }, { "id": "550", "type": "CID", "arg1_id": "533", "arg2_id": "527", "normalized": [] }, { "id": "551", "type": "CID", "arg1_id": "533", "arg2_id": "531", "normalized": [] }, { "id": "552", "type": "CID", "arg1_id": "533", "arg2_id": "534", "normalized": [] }, { "id": "553", "type": "CID", "arg1_id": "533", "arg2_id": "541", "normalized": [] }, { "id": "554", "type": "CID", "arg1_id": "540", "arg2_id": "527", "normalized": [] }, { "id": "555", "type": "CID", "arg1_id": "540", "arg2_id": "531", "normalized": [] }, { "id": "556", "type": "CID", "arg1_id": "540", "arg2_id": "534", "normalized": [] }, { "id": "557", "type": "CID", "arg1_id": "540", "arg2_id": "541", "normalized": [] } ]

[ { "id": "559", "type": "title", "text": [ "Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat." ], "offsets": [ [ 0, 150 ] ] }, { "id": "560", "type": "abstract", "text": [ "Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (ACE), reduced both pulmonary and renal insufficiency in this rat model. The lung weights were lower and PaO2 was improved in rats given this enzyme-blocking agent. The contents of albumin in the lungs were not changed, indicating that Captopril did not influence the extravasation of protein. Renal damage as reflected by an increase in serum urea and in kidney weight was prevented by Captopril. The amount of fibrin in the kidneys was also considerably lower than in animals which received thrombin and AMCA alone. It is suggested that the effects of Captopril on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin). Captopril may, by the same mechanism, reduce the increase in glomerular filtration that is known to occur after an injection of thrombin, thereby diminishing the aggregation of fibrin monomers in the glomeruli, with the result that less fibrin will be deposited and thus less kidney damage will be produced." ], "offsets": [ [ 151, 1535 ] ] } ]

[ { "id": "561", "type": "Chemical", "text": [ "angiotensin" ], "offsets": [ [ 27, 38 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000809" } ] }, { "id": "562", "type": "Chemical", "text": [ "Captopril" ], "offsets": [ [ 58, 67 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002216" } ] }, { "id": "563", "type": "Disease", "text": [ "pulmonary and renal insufficiency" ], "offsets": [ [ 72, 105 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011665" }, { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "564", "type": "Disease", "text": [ "pulmonary", "insufficiency" ], "offsets": [ [ 72, 81 ], [ 92, 105 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011665" } ] }, { "id": "565", "type": "Disease", "text": [ "renal insufficiency" ], "offsets": [ [ 86, 105 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "566", "type": "Disease", "text": [ "intravascular coagulation" ], "offsets": [ [ 113, 138 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004211" } ] }, { "id": "567", "type": "Disease", "text": [ "intravascular coagulation" ], "offsets": [ [ 164, 189 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004211" } ] }, { "id": "568", "type": "Chemical", "text": [ "tranexamic acid" ], "offsets": [ [ 250, 265 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014148" } ] }, { "id": "569", "type": "Chemical", "text": [ "AMCA" ], "offsets": [ [ 267, 271 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014148" } ] }, { "id": "570", "type": "Disease", "text": [ "pulmonary and renal insufficiency" ], "offsets": [ [ 298, 331 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011665" }, { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "571", "type": "Disease", "text": [ "pulmonary", "insufficiency" ], "offsets": [ [ 298, 307 ], [ 318, 331 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011665" } ] }, { "id": "572", "type": "Disease", "text": [ "renal insufficiency" ], "offsets": [ [ 312, 331 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "573", "type": "Disease", "text": [ "trauma" ], "offsets": [ [ 364, 370 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014947" } ] }, { "id": "574", "type": "Disease", "text": [ "sepsis" ], "offsets": [ [ 374, 380 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018805" } ] }, { "id": "575", "type": "Chemical", "text": [ "Captopril" ], "offsets": [ [ 402, 411 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002216" } ] }, { "id": "576", "type": "Chemical", "text": [ "angiotensin" ], "offsets": [ [ 439, 450 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000809" } ] }, { "id": "577", "type": "Disease", "text": [ "pulmonary and renal insufficiency" ], "offsets": [ [ 489, 522 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011665" }, { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "578", "type": "Disease", "text": [ "pulmonary", "insufficiency" ], "offsets": [ [ 489, 498 ], [ 509, 522 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011665" } ] }, { "id": "579", "type": "Disease", "text": [ "renal insufficiency" ], "offsets": [ [ 503, 522 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "580", "type": "Chemical", "text": [ "Captopril" ], "offsets": [ [ 705, 714 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002216" } ] }, { "id": "581", "type": "Disease", "text": [ "Renal damage" ], "offsets": [ [ 763, 775 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "582", "type": "Chemical", "text": [ "urea" ], "offsets": [ [ 813, 817 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014508" } ] }, { "id": "583", "type": "Chemical", "text": [ "Captopril" ], "offsets": [ [ 856, 865 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002216" } ] }, { "id": "584", "type": "Chemical", "text": [ "AMCA" ], "offsets": [ [ 975, 979 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014148" } ] }, { "id": "585", "type": "Chemical", "text": [ "Captopril" ], "offsets": [ [ 1023, 1032 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002216" } ] }, { "id": "586", "type": "Chemical", "text": [ "Angiotension II" ], "offsets": [ [ 1138, 1153 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000804" } ] }, { "id": "587", "type": "Chemical", "text": [ "prostacyclin" ], "offsets": [ [ 1173, 1185 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011464" } ] }, { "id": "588", "type": "Chemical", "text": [ "bradykinin" ], "offsets": [ [ 1215, 1225 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001920" } ] }, { "id": "589", "type": "Chemical", "text": [ "Captopril" ], "offsets": [ [ 1228, 1237 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002216" } ] }, { "id": "590", "type": "Disease", "text": [ "kidney damage" ], "offsets": [ [ 1504, 1517 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] } ]

[]

[]

[ { "id": "591", "type": "CID", "arg1_id": "568", "arg2_id": "566", "normalized": [] }, { "id": "592", "type": "CID", "arg1_id": "568", "arg2_id": "567", "normalized": [] }, { "id": "593", "type": "CID", "arg1_id": "569", "arg2_id": "566", "normalized": [] }, { "id": "594", "type": "CID", "arg1_id": "569", "arg2_id": "567", "normalized": [] }, { "id": "595", "type": "CID", "arg1_id": "584", "arg2_id": "566", "normalized": [] }, { "id": "596", "type": "CID", "arg1_id": "584", "arg2_id": "567", "normalized": [] } ]

[ { "id": "598", "type": "title", "text": [ "A randomized comparison of labetalol and nitroprusside for induced hypotension." ], "offsets": [ [ 0, 79 ] ] }, { "id": "599", "type": "abstract", "text": [ "In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced reductions in mean arterial blood pressure (BP) (50 to 55 mmHg). Nitroprusside infusion was associated with a significant (p less than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after discontinuation of nitroprusside. Labetalol administration was not associated with any of these findings. Arterial PO2 decreased in both groups. It was concluded that labetalol offers advantages over nitroprusside." ], "offsets": [ [ 80, 806 ] ] } ]

[ { "id": "600", "type": "Chemical", "text": [ "labetalol" ], "offsets": [ [ 27, 36 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007741" } ] }, { "id": "601", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 41, 54 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "602", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 67, 78 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "603", "type": "Chemical", "text": [ "labetalol" ], "offsets": [ [ 103, 112 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007741" } ] }, { "id": "604", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 121, 132 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "605", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 137, 150 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "606", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 159, 170 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "607", "type": "Disease", "text": [ "reductions in mean arterial blood pressure" ], "offsets": [ [ 350, 392 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "608", "type": "Disease", "text": [ "increase in heart rate and cardiac output" ], "offsets": [ [ 491, 532 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016534" } ] }, { "id": "609", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 542, 554 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "610", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 611, 624 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "611", "type": "Chemical", "text": [ "Labetalol" ], "offsets": [ [ 626, 635 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007741" } ] }, { "id": "612", "type": "Chemical", "text": [ "PO2" ], "offsets": [ [ 707, 710 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C093415" } ] }, { "id": "613", "type": "Chemical", "text": [ "labetalol" ], "offsets": [ [ 759, 768 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007741" } ] }, { "id": "614", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 792, 805 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] } ]

[]

[]

[ { "id": "615", "type": "CID", "arg1_id": "601", "arg2_id": "602", "normalized": [] }, { "id": "616", "type": "CID", "arg1_id": "601", "arg2_id": "604", "normalized": [] }, { "id": "617", "type": "CID", "arg1_id": "601", "arg2_id": "606", "normalized": [] }, { "id": "618", "type": "CID", "arg1_id": "601", "arg2_id": "607", "normalized": [] }, { "id": "619", "type": "CID", "arg1_id": "605", "arg2_id": "602", "normalized": [] }, { "id": "620", "type": "CID", "arg1_id": "605", "arg2_id": "604", "normalized": [] }, { "id": "621", "type": "CID", "arg1_id": "605", "arg2_id": "606", "normalized": [] }, { "id": "622", "type": "CID", "arg1_id": "605", "arg2_id": "607", "normalized": [] }, { "id": "623", "type": "CID", "arg1_id": "610", "arg2_id": "602", "normalized": [] }, { "id": "624", "type": "CID", "arg1_id": "610", "arg2_id": "604", "normalized": [] }, { "id": "625", "type": "CID", "arg1_id": "610", "arg2_id": "606", "normalized": [] }, { "id": "626", "type": "CID", "arg1_id": "610", "arg2_id": "607", "normalized": [] }, { "id": "627", "type": "CID", "arg1_id": "614", "arg2_id": "602", "normalized": [] }, { "id": "628", "type": "CID", "arg1_id": "614", "arg2_id": "604", "normalized": [] }, { "id": "629", "type": "CID", "arg1_id": "614", "arg2_id": "606", "normalized": [] }, { "id": "630", "type": "CID", "arg1_id": "614", "arg2_id": "607", "normalized": [] }, { "id": "631", "type": "CID", "arg1_id": "601", "arg2_id": "608", "normalized": [] }, { "id": "632", "type": "CID", "arg1_id": "605", "arg2_id": "608", "normalized": [] }, { "id": "633", "type": "CID", "arg1_id": "610", "arg2_id": "608", "normalized": [] }, { "id": "634", "type": "CID", "arg1_id": "614", "arg2_id": "608", "normalized": [] }, { "id": "635", "type": "CID", "arg1_id": "600", "arg2_id": "602", "normalized": [] }, { "id": "636", "type": "CID", "arg1_id": "600", "arg2_id": "604", "normalized": [] }, { "id": "637", "type": "CID", "arg1_id": "600", "arg2_id": "606", "normalized": [] }, { "id": "638", "type": "CID", "arg1_id": "600", "arg2_id": "607", "normalized": [] }, { "id": "639", "type": "CID", "arg1_id": "603", "arg2_id": "602", "normalized": [] }, { "id": "640", "type": "CID", "arg1_id": "603", "arg2_id": "604", "normalized": [] }, { "id": "641", "type": "CID", "arg1_id": "603", "arg2_id": "606", "normalized": [] }, { "id": "642", "type": "CID", "arg1_id": "603", "arg2_id": "607", "normalized": [] }, { "id": "643", "type": "CID", "arg1_id": "611", "arg2_id": "602", "normalized": [] }, { "id": "644", "type": "CID", "arg1_id": "611", "arg2_id": "604", "normalized": [] }, { "id": "645", "type": "CID", "arg1_id": "611", "arg2_id": "606", "normalized": [] }, { "id": "646", "type": "CID", "arg1_id": "611", "arg2_id": "607", "normalized": [] }, { "id": "647", "type": "CID", "arg1_id": "613", "arg2_id": "602", "normalized": [] }, { "id": "648", "type": "CID", "arg1_id": "613", "arg2_id": "604", "normalized": [] }, { "id": "649", "type": "CID", "arg1_id": "613", "arg2_id": "606", "normalized": [] }, { "id": "650", "type": "CID", "arg1_id": "613", "arg2_id": "607", "normalized": [] } ]

[ { "id": "652", "type": "title", "text": [ "Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations." ], "offsets": [ [ 0, 118 ] ] }, { "id": "653", "type": "abstract", "text": [ "Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat. In the course of developing this model, a common vehicle, propylene glycol, by itself in high doses, was found to exhibit protective properties against induced seizures and inhibited weight gain. Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protection by CBZ than seizures induced by maximal electroshock (MES). Oral administration of CBZ as an aqueous suspension every 8 h at a dose of 250 mg/kg was continuously protective against HFDE-induced seizures and was minimally toxic as measured by weight gain over 8 weeks of treatment. The CBZ levels measured in plasma and brain of these animals, however, were below those normally considered protective. This treatment with CBZ had no apparent adverse effect on folate concentrations in the rat, and, indeed, the folate concentration increased in liver after 6 weeks of treatment and in plasma at 8 weeks of treatment." ], "offsets": [ [ 119, 1328 ] ] } ]

[ { "id": "654", "type": "Chemical", "text": [ "carbamazepine" ], "offsets": [ [ 8, 21 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002220" } ] }, { "id": "655", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 54, 62 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "656", "type": "Chemical", "text": [ "folate" ], "offsets": [ [ 96, 102 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005492" } ] }, { "id": "657", "type": "Chemical", "text": [ "Folate" ], "offsets": [ [ 119, 125 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005492" } ] }, { "id": "658", "type": "Chemical", "text": [ "Carbamazepine" ], "offsets": [ [ 206, 219 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002220" } ] }, { "id": "659", "type": "Chemical", "text": [ "CBZ" ], "offsets": [ [ 221, 224 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002220" } ] }, { "id": "660", "type": "Chemical", "text": [ "CBZ" ], "offsets": [ [ 354, 357 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002220" } ] }, { "id": "661", "type": "Chemical", "text": [ "folate" ], "offsets": [ [ 371, 377 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005492" } ] }, { "id": "662", "type": "Chemical", "text": [ "propylene glycol" ], "offsets": [ [ 463, 479 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019946" } ] }, { "id": "663", "type": "Disease", "text": [ "seizures" ], "offsets": [ [ 565, 573 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012640" } ] }, { "id": "664", "type": "Disease", "text": [ "weight gain" ], "offsets": [ [ 588, 599 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015430" } ] }, { "id": "665", "type": "Disease", "text": [ "Seizures" ], "offsets": [ [ 601, 609 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012640" } ] }, { "id": "666", "type": "Chemical", "text": [ "hexafluorodiethyl ether" ], "offsets": [ [ 621, 644 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005481" } ] }, { "id": "667", "type": "Chemical", "text": [ "HFDE" ], "offsets": [ [ 646, 650 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005481" } ] }, { "id": "668", "type": "Chemical", "text": [ "CBZ" ], "offsets": [ [ 716, 719 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002220" } ] }, { "id": "669", "type": "Disease", "text": [ "seizures" ], "offsets": [ [ 725, 733 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012640" } ] }, { "id": "670", "type": "Chemical", "text": [ "CBZ" ], "offsets": [ [ 796, 799 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002220" } ] }, { "id": "671", "type": "Chemical", "text": [ "HFDE" ], "offsets": [ [ 894, 898 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005481" } ] }, { "id": "672", "type": "Disease", "text": [ "seizures" ], "offsets": [ [ 907, 915 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012640" } ] }, { "id": "673", "type": "Disease", "text": [ "weight gain" ], "offsets": [ [ 955, 966 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015430" } ] }, { "id": "674", "type": "Chemical", "text": [ "CBZ" ], "offsets": [ [ 998, 1001 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002220" } ] }, { "id": "675", "type": "Chemical", "text": [ "CBZ" ], "offsets": [ [ 1134, 1137 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002220" } ] }, { "id": "676", "type": "Chemical", "text": [ "folate" ], "offsets": [ [ 1172, 1178 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005492" } ] }, { "id": "677", "type": "Chemical", "text": [ "folate" ], "offsets": [ [ 1223, 1229 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005492" } ] } ]

[]

[]

[ { "id": "678", "type": "CID", "arg1_id": "666", "arg2_id": "663", "normalized": [] }, { "id": "679", "type": "CID", "arg1_id": "666", "arg2_id": "665", "normalized": [] }, { "id": "680", "type": "CID", "arg1_id": "666", "arg2_id": "669", "normalized": [] }, { "id": "681", "type": "CID", "arg1_id": "666", "arg2_id": "672", "normalized": [] }, { "id": "682", "type": "CID", "arg1_id": "667", "arg2_id": "663", "normalized": [] }, { "id": "683", "type": "CID", "arg1_id": "667", "arg2_id": "665", "normalized": [] }, { "id": "684", "type": "CID", "arg1_id": "667", "arg2_id": "669", "normalized": [] }, { "id": "685", "type": "CID", "arg1_id": "667", "arg2_id": "672", "normalized": [] }, { "id": "686", "type": "CID", "arg1_id": "671", "arg2_id": "663", "normalized": [] }, { "id": "687", "type": "CID", "arg1_id": "671", "arg2_id": "665", "normalized": [] }, { "id": "688", "type": "CID", "arg1_id": "671", "arg2_id": "669", "normalized": [] }, { "id": "689", "type": "CID", "arg1_id": "671", "arg2_id": "672", "normalized": [] } ]

[ { "id": "691", "type": "title", "text": [ "Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs." ], "offsets": [ [ 0, 76 ] ] }, { "id": "692", "type": "abstract", "text": [ "In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor. Mean arterial pressure (as a percentage of control +/- SEM) during randomized infusions of 0.03, 0.1, 0.3, or 1.0 microgram/kg/min was 99 +/- 1, 95 +/- 1 (p less than 0.05), 93 +/- 1 (p less than 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation of the norepinephrine release rate (up to 0.3 microgram/kg/min) were observed, which is in contrast to comparable hypotension induced by hydralazine or nitroglycerin. The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/min) declined immediately during infusions of atrial natriuretic factor to a minimum of 49 +/- 5% of control (p less than 0.001) during 0.1 microgram/kg/min and to 63 +/- 5% (0.1 greater than p greater than 0.05) or 95 +/- 13% (not significant) during 0.3 or 1.0 microgram/kg/min. Steady state arterial plasma concentrations of atrial natriuretic factor were 39 +/- 10 pg/ml (n = 6) during infusions of saline and 284 +/- 24 pg/ml (n = 6) and 1520 +/- 300 pg/ml (n = 9) during 0.03 and 0.1 microgram/kg/min infusions of the factor.(ABSTRACT TRUNCATED AT 250 WORDS)" ], "offsets": [ [ 77, 1411 ] ] } ]

[ { "id": "693", "type": "Chemical", "text": [ "sodium" ], "offsets": [ [ 132, 138 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012964" } ] }, { "id": "694", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 225, 239 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009638" } ] }, { "id": "695", "type": "Chemical", "text": [ "epinephrine" ], "offsets": [ [ 244, 255 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004837" } ] }, { "id": "696", "type": "Disease", "text": [ "tachycardia" ], "offsets": [ [ 588, 599 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013610" } ] }, { "id": "697", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 627, 641 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009638" } ] }, { "id": "698", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 734, 745 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "699", "type": "Chemical", "text": [ "hydralazine" ], "offsets": [ [ 757, 768 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006830" } ] }, { "id": "700", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 772, 785 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "701", "type": "Chemical", "text": [ "epinephrine" ], "offsets": [ [ 807, 818 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004837" } ] } ]

[]

[]

[ { "id": "702", "type": "CID", "arg1_id": "700", "arg2_id": "698", "normalized": [] }, { "id": "703", "type": "CID", "arg1_id": "699", "arg2_id": "698", "normalized": [] } ]

[ { "id": "705", "type": "title", "text": [ "Death from chemotherapy in gestational trophoblastic disease." ], "offsets": [ [ 0, 61 ] ] }, { "id": "706", "type": "abstract", "text": [ "Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin. On the first day of the schedule, moderate high doses of Methotrexate, Etoposide and Cyclophosphamide were administered. Within 8 hours after initiation of therapy the patient died with a clinical picture resembling massive pulmonary obstruction due to choriocarcinomic tissue plugs, probably originating from the uterus. Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli. In view of the close time association between the start of chemotherapy and the acute onset of massive embolism other explanations, such as spontaneous necrosis, must be considered less likely. Patients with large pelvic tumor loads are, according to existing classifications, at high risk to die and to develop drug resistance. Notwithstanding these facts our findings suggest that these patients might benefit from relatively mild initial treatment, especially true for patients not previously exposed to this drug. Close observation of the response status both clinically and with beta-hCG values may indicate whether and when more agressive combination chemotherapy should be started.(ABSTRACT TRUNCATED AT 250 WORDS)" ], "offsets": [ [ 62, 1842 ] ] } ]

[ { "id": "707", "type": "Disease", "text": [ "Death" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003643" } ] }, { "id": "708", "type": "Disease", "text": [ "gestational trophoblastic disease" ], "offsets": [ [ 27, 60 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D031901" } ] }, { "id": "709", "type": "Disease", "text": [ "choriocarcinoma" ], "offsets": [ [ 175, 190 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002822" } ] }, { "id": "710", "type": "Chemical", "text": [ "Etoposide" ], "offsets": [ [ 399, 408 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005047" } ] }, { "id": "711", "type": "Chemical", "text": [ "Methotrexate" ], "offsets": [ [ 417, 429 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008727" } ] }, { "id": "712", "type": "Chemical", "text": [ "Cyclophosphamide" ], "offsets": [ [ 431, 447 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003520" } ] }, { "id": "713", "type": "Chemical", "text": [ "Actomycin-D" ], "offsets": [ [ 449, 460 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003609" } ] }, { "id": "714", "type": "Chemical", "text": [ "Cisplatin" ], "offsets": [ [ 466, 475 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002945" } ] }, { "id": "715", "type": "Chemical", "text": [ "Methotrexate" ], "offsets": [ [ 534, 546 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008727" } ] }, { "id": "716", "type": "Chemical", "text": [ "Etoposide" ], "offsets": [ [ 548, 557 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005047" } ] }, { "id": "717", "type": "Chemical", "text": [ "Cyclophosphamide" ], "offsets": [ [ 562, 578 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003520" } ] }, { "id": "718", "type": "Disease", "text": [ "pulmonary obstruction" ], "offsets": [ [ 701, 722 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011655" } ] }, { "id": "719", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 854, 859 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "720", "type": "Disease", "text": [ "necrosis" ], "offsets": [ [ 860, 868 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009336" } ] }, { "id": "721", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 961, 966 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "722", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 1009, 1014 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "723", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 1107, 1112 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "724", "type": "Disease", "text": [ "embolism" ], "offsets": [ [ 1224, 1232 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004617" } ] }, { "id": "725", "type": "Disease", "text": [ "necrosis" ], "offsets": [ [ 1273, 1281 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009336" } ] }, { "id": "726", "type": "Disease", "text": [ "pelvic tumor" ], "offsets": [ [ 1335, 1347 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010386" } ] } ]

[]

[]

[ { "id": "727", "type": "CID", "arg1_id": "710", "arg2_id": "718", "normalized": [] }, { "id": "728", "type": "CID", "arg1_id": "716", "arg2_id": "718", "normalized": [] }, { "id": "729", "type": "CID", "arg1_id": "711", "arg2_id": "718", "normalized": [] }, { "id": "730", "type": "CID", "arg1_id": "715", "arg2_id": "718", "normalized": [] }, { "id": "731", "type": "CID", "arg1_id": "712", "arg2_id": "718", "normalized": [] }, { "id": "732", "type": "CID", "arg1_id": "717", "arg2_id": "718", "normalized": [] } ]

[ { "id": "734", "type": "title", "text": [ "Sexual dysfunction among patients with arthritis." ], "offsets": [ [ 0, 49 ] ] }, { "id": "735", "type": "abstract", "text": [ "The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of marital happiness and depressed mood were also made using the CES-D and the Azrin Marital Happiness Scale (AMHS). Sexual dysfunctions were found to be common among patients and controls, the majority in both groups reporting one or more dysfunctions. Impotence was more common among male patients than controls and was found to be associated with co-morbidity and the taking of methotrexate. Depressed mood was more common among patients and was associated with certain sexual difficulties, but not with impotence. Marital unhappiness, as indicated by AMHS scores, was not associated with arthritis but was associated with sexual dysfunction, sexual dissatisfaction and being female." ], "offsets": [ [ 50, 947 ] ] } ]

[ { "id": "736", "type": "Disease", "text": [ "Sexual dysfunction" ], "offsets": [ [ 0, 18 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012735" } ] }, { "id": "737", "type": "Disease", "text": [ "arthritis" ], "offsets": [ [ 39, 48 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001168" } ] }, { "id": "738", "type": "Disease", "text": [ "arthritis" ], "offsets": [ [ 70, 79 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001168" } ] }, { "id": "739", "type": "Disease", "text": [ "sexual dysfunction" ], "offsets": [ [ 84, 102 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012735" } ] }, { "id": "740", "type": "Disease", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 144, 164 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001172" } ] }, { "id": "741", "type": "Disease", "text": [ "osteoarthritis" ], "offsets": [ [ 166, 180 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010003" } ] }, { "id": "742", "type": "Disease", "text": [ "spondyloarthropathy" ], "offsets": [ [ 185, 204 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D025242" } ] }, { "id": "743", "type": "Disease", "text": [ "depressed mood" ], "offsets": [ [ 286, 300 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "744", "type": "Disease", "text": [ "Sexual dysfunctions" ], "offsets": [ [ 378, 397 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012735" } ] }, { "id": "745", "type": "Disease", "text": [ "Impotence" ], "offsets": [ [ 515, 524 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007172" } ] }, { "id": "746", "type": "Chemical", "text": [ "methotrexate" ], "offsets": [ [ 642, 654 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008727" } ] }, { "id": "747", "type": "Disease", "text": [ "Depressed mood" ], "offsets": [ [ 656, 670 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "748", "type": "Disease", "text": [ "impotence" ], "offsets": [ [ 768, 777 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007172" } ] }, { "id": "749", "type": "Disease", "text": [ "arthritis" ], "offsets": [ [ 853, 862 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001168" } ] }, { "id": "750", "type": "Disease", "text": [ "sexual dysfunction" ], "offsets": [ [ 887, 905 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012735" } ] } ]

[]

[]

[ { "id": "751", "type": "CID", "arg1_id": "746", "arg2_id": "745", "normalized": [] }, { "id": "752", "type": "CID", "arg1_id": "746", "arg2_id": "748", "normalized": [] } ]

[ { "id": "754", "type": "title", "text": [ "Does paracetamol cause urothelial cancer or renal papillary necrosis?" ], "offsets": [ [ 0, 69 ] ] }, { "id": "755", "type": "abstract", "text": [ "The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consumption of phenacetin, which also increased the risk for cancer of the renal pelvis and bladder but not for ureteric cancer. By contrast, we were unable to substantiate an increased risk from paracetamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter." ], "offsets": [ [ 70, 733 ] ] } ]

[ { "id": "756", "type": "Chemical", "text": [ "paracetamol" ], "offsets": [ [ 5, 16 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "757", "type": "Disease", "text": [ "urothelial cancer" ], "offsets": [ [ 23, 40 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014523" } ] }, { "id": "758", "type": "Disease", "text": [ "renal papillary necrosis" ], "offsets": [ [ 44, 68 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007681" } ] }, { "id": "759", "type": "Disease", "text": [ "renal papillary necrosis" ], "offsets": [ [ 93, 117 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007681" } ] }, { "id": "760", "type": "Disease", "text": [ "cancer of the renal pelvis, ureter or bladder" ], "offsets": [ [ 121, 166 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007680" }, { "db_name": "MESH", "db_id": "D014516" }, { "db_name": "MESH", "db_id": "D001749" } ] }, { "id": "761", "type": "Disease", "text": [ "cancer of the renal pelvis" ], "offsets": [ [ 121, 147 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007680" } ] }, { "id": "762", "type": "Disease", "text": [ "cancer of the", "ureter" ], "offsets": [ [ 121, 134 ], [ 149, 155 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014516" } ] }, { "id": "763", "type": "Disease", "text": [ "cancer of the", "bladder" ], "offsets": [ [ 121, 134 ], [ 159, 166 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001749" } ] }, { "id": "764", "type": "Chemical", "text": [ "phenacetin" ], "offsets": [ [ 205, 215 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010615" } ] }, { "id": "765", "type": "Chemical", "text": [ "paracetamol" ], "offsets": [ [ 219, 230 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "766", "type": "Disease", "text": [ "renal papillary necrosis" ], "offsets": [ [ 327, 351 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007681" } ] }, { "id": "767", "type": "Chemical", "text": [ "phenacetin" ], "offsets": [ [ 399, 409 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010615" } ] }, { "id": "768", "type": "Disease", "text": [ "cancer of the renal pelvis and bladder" ], "offsets": [ [ 445, 483 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007680" }, { "db_name": "MESH", "db_id": "D001749" } ] }, { "id": "769", "type": "Disease", "text": [ "cancer of the renal pelvis" ], "offsets": [ [ 445, 471 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007680" } ] }, { "id": "770", "type": "Disease", "text": [ "cancer of the", "bladder" ], "offsets": [ [ 445, 458 ], [ 476, 483 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001749" } ] }, { "id": "771", "type": "Disease", "text": [ "ureteric cancer" ], "offsets": [ [ 496, 511 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014516" } ] }, { "id": "772", "type": "Chemical", "text": [ "paracetamol" ], "offsets": [ [ 580, 591 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "773", "type": "Disease", "text": [ "renal papillary necrosis" ], "offsets": [ [ 608, 632 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007681" } ] }, { "id": "774", "type": "Disease", "text": [ "cancers" ], "offsets": [ [ 649, 656 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "775", "type": "Disease", "text": [ "cancer of the ureter" ], "offsets": [ [ 712, 732 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014516" } ] } ]

[]

[]

[ { "id": "776", "type": "CID", "arg1_id": "764", "arg2_id": "758", "normalized": [] }, { "id": "777", "type": "CID", "arg1_id": "764", "arg2_id": "759", "normalized": [] }, { "id": "778", "type": "CID", "arg1_id": "764", "arg2_id": "766", "normalized": [] }, { "id": "779", "type": "CID", "arg1_id": "764", "arg2_id": "773", "normalized": [] }, { "id": "780", "type": "CID", "arg1_id": "767", "arg2_id": "758", "normalized": [] }, { "id": "781", "type": "CID", "arg1_id": "767", "arg2_id": "759", "normalized": [] }, { "id": "782", "type": "CID", "arg1_id": "767", "arg2_id": "766", "normalized": [] }, { "id": "783", "type": "CID", "arg1_id": "767", "arg2_id": "773", "normalized": [] }, { "id": "784", "type": "CID", "arg1_id": "764", "arg2_id": "760", "normalized": [] }, { "id": "785", "type": "CID", "arg1_id": "764", "arg2_id": "763", "normalized": [] }, { "id": "786", "type": "CID", "arg1_id": "764", "arg2_id": "768", "normalized": [] }, { "id": "787", "type": "CID", "arg1_id": "764", "arg2_id": "770", "normalized": [] }, { "id": "788", "type": "CID", "arg1_id": "767", "arg2_id": "760", "normalized": [] }, { "id": "789", "type": "CID", "arg1_id": "767", "arg2_id": "763", "normalized": [] }, { "id": "790", "type": "CID", "arg1_id": "767", "arg2_id": "768", "normalized": [] }, { "id": "791", "type": "CID", "arg1_id": "767", "arg2_id": "770", "normalized": [] }, { "id": "792", "type": "CID", "arg1_id": "764", "arg2_id": "760", "normalized": [] }, { "id": "793", "type": "CID", "arg1_id": "764", "arg2_id": "761", "normalized": [] }, { "id": "794", "type": "CID", "arg1_id": "764", "arg2_id": "768", "normalized": [] }, { "id": "795", "type": "CID", "arg1_id": "764", "arg2_id": "769", "normalized": [] }, { "id": "796", "type": "CID", "arg1_id": "767", "arg2_id": "760", "normalized": [] }, { "id": "797", "type": "CID", "arg1_id": "767", "arg2_id": "761", "normalized": [] }, { "id": "798", "type": "CID", "arg1_id": "767", "arg2_id": "768", "normalized": [] }, { "id": "799", "type": "CID", "arg1_id": "767", "arg2_id": "769", "normalized": [] } ]

[ { "id": "801", "type": "title", "text": [ "Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait." ], "offsets": [ [ 0, 92 ] ] }, { "id": "802", "type": "abstract", "text": [ "A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability. The pentose phosphate shunt activity of the dapsone-exposed AE RBCs was increased compared to normal RBCs. Although the AE RBCs from an individual not taking dapsone had increased incubated Heinz body formation, the GSH content and GSH stability were normal. The pentose phosphate shunt activity of the non-dapsone-exposed AE RBCs was decreased compared to normal RBCs. Thus, AE RBCs appear to have an increased sensitivity to oxidant stress both in vitro and in vivo, since dapsone does not cause hemolytic anemia at this dose in hematologically normal individuals. Given the influx of Southeast Asians into the United States, oxidant medications should be used with caution, especially if an infection is present, in individuals of ethnic backgrounds that have an increased prevalence of hemoglobin E." ], "offsets": [ [ 93, 1225 ] ] } ]

[ { "id": "803", "type": "Chemical", "text": [ "Dapsone" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003622" } ] }, { "id": "804", "type": "Disease", "text": [ "hemolytic anemia" ], "offsets": [ [ 30, 46 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000743" } ] }, { "id": "805", "type": "Disease", "text": [ "leprosy" ], "offsets": [ [ 144, 151 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007918" } ] }, { "id": "806", "type": "Disease", "text": [ "hemolytic anemia" ], "offsets": [ [ 175, 191 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000743" } ] }, { "id": "807", "type": "Chemical", "text": [ "dapsone" ], "offsets": [ [ 215, 222 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003622" } ] }, { "id": "808", "type": "Disease", "text": [ "hemolysis" ], "offsets": [ [ 272, 281 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006461" } ] }, { "id": "809", "type": "Chemical", "text": [ "glutathione" ], "offsets": [ [ 374, 385 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005978" } ] }, { "id": "810", "type": "Chemical", "text": [ "GSH" ], "offsets": [ [ 387, 390 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005978" } ] }, { "id": "811", "type": "Chemical", "text": [ "GSH" ], "offsets": [ [ 407, 410 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005978" } ] }, { "id": "812", "type": "Chemical", "text": [ "pentose phosphate" ], "offsets": [ [ 426, 443 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010428" } ] }, { "id": "813", "type": "Chemical", "text": [ "dapsone" ], "offsets": [ [ 466, 473 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003622" } ] }, { "id": "814", "type": "Chemical", "text": [ "dapsone" ], "offsets": [ [ 580, 587 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003622" } ] }, { "id": "815", "type": "Chemical", "text": [ "GSH" ], "offsets": [ [ 638, 641 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005978" } ] }, { "id": "816", "type": "Chemical", "text": [ "GSH" ], "offsets": [ [ 654, 657 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005978" } ] }, { "id": "817", "type": "Chemical", "text": [ "pentose phosphate" ], "offsets": [ [ 685, 702 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010428" } ] }, { "id": "818", "type": "Chemical", "text": [ "dapsone" ], "offsets": [ [ 729, 736 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003622" } ] }, { "id": "819", "type": "Chemical", "text": [ "dapsone" ], "offsets": [ [ 897, 904 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003622" } ] }, { "id": "820", "type": "Disease", "text": [ "hemolytic anemia" ], "offsets": [ [ 920, 936 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000743" } ] }, { "id": "821", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 1116, 1125 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007239" } ] } ]

[]

[]

[ { "id": "822", "type": "CID", "arg1_id": "803", "arg2_id": "804", "normalized": [] }, { "id": "823", "type": "CID", "arg1_id": "803", "arg2_id": "806", "normalized": [] }, { "id": "824", "type": "CID", "arg1_id": "803", "arg2_id": "820", "normalized": [] }, { "id": "825", "type": "CID", "arg1_id": "807", "arg2_id": "804", "normalized": [] }, { "id": "826", "type": "CID", "arg1_id": "807", "arg2_id": "806", "normalized": [] }, { "id": "827", "type": "CID", "arg1_id": "807", "arg2_id": "820", "normalized": [] }, { "id": "828", "type": "CID", "arg1_id": "813", "arg2_id": "804", "normalized": [] }, { "id": "829", "type": "CID", "arg1_id": "813", "arg2_id": "806", "normalized": [] }, { "id": "830", "type": "CID", "arg1_id": "813", "arg2_id": "820", "normalized": [] }, { "id": "831", "type": "CID", "arg1_id": "814", "arg2_id": "804", "normalized": [] }, { "id": "832", "type": "CID", "arg1_id": "814", "arg2_id": "806", "normalized": [] }, { "id": "833", "type": "CID", "arg1_id": "814", "arg2_id": "820", "normalized": [] }, { "id": "834", "type": "CID", "arg1_id": "818", "arg2_id": "804", "normalized": [] }, { "id": "835", "type": "CID", "arg1_id": "818", "arg2_id": "806", "normalized": [] }, { "id": "836", "type": "CID", "arg1_id": "818", "arg2_id": "820", "normalized": [] }, { "id": "837", "type": "CID", "arg1_id": "819", "arg2_id": "804", "normalized": [] }, { "id": "838", "type": "CID", "arg1_id": "819", "arg2_id": "806", "normalized": [] }, { "id": "839", "type": "CID", "arg1_id": "819", "arg2_id": "820", "normalized": [] } ]

[ { "id": "841", "type": "title", "text": [ "Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine." ], "offsets": [ [ 0, 148 ] ] }, { "id": "842", "type": "abstract", "text": [ "A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition. Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and diltiazem (526 ng/ml). The patient recovered within 1 week following discontinuation of antianginal therapy. Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism). It was found that he was a poor metabolizer of all four drugs, indicating that their metabolism is under the same genetic control. Therefore, patients belonging to the poor-metabolizer phenotype of sparteine/debrisoquine polymorphism in drug metabolism, which constitutes 6.4% of the German population, may experience adverse drug reactions when treated with standard doses of one of these drugs alone. Moreover, the coadministration of these frequently used drugs is expected to be especially harmful in this subgroup of patients." ], "offsets": [ [ 149, 1541 ] ] } ]

[ { "id": "843", "type": "Chemical", "text": [ "metoprolol" ], "offsets": [ [ 98, 108 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008790" } ] }, { "id": "844", "type": "Chemical", "text": [ "propafenone" ], "offsets": [ [ 110, 121 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011405" } ] }, { "id": "845", "type": "Chemical", "text": [ "diltiazem" ], "offsets": [ [ 123, 132 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004110" } ] }, { "id": "846", "type": "Chemical", "text": [ "sparteine" ], "offsets": [ [ 138, 147 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013034" } ] }, { "id": "847", "type": "Disease", "text": [ "coronary artery disease" ], "offsets": [ [ 186, 209 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003324" } ] }, { "id": "848", "type": "Disease", "text": [ "shock" ], "offsets": [ [ 237, 242 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012769" } ] }, { "id": "849", "type": "Disease", "text": [ "AV block" ], "offsets": [ [ 253, 261 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054537" } ] }, { "id": "850", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 270, 281 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "851", "type": "Disease", "text": [ "impairment of ventricular function" ], "offsets": [ [ 287, 321 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018754" } ] }, { "id": "852", "type": "Chemical", "text": [ "metoprolol" ], "offsets": [ [ 384, 394 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008790" } ] }, { "id": "853", "type": "Chemical", "text": [ "diltiazem" ], "offsets": [ [ 480, 489 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004110" } ] }, { "id": "854", "type": "Chemical", "text": [ "metoprolol" ], "offsets": [ [ 609, 619 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008790" } ] }, { "id": "855", "type": "Chemical", "text": [ "diltiazem" ], "offsets": [ [ 650, 659 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004110" } ] }, { "id": "856", "type": "Chemical", "text": [ "metoprolol" ], "offsets": [ [ 822, 832 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008790" } ] }, { "id": "857", "type": "Chemical", "text": [ "diltiazem" ], "offsets": [ [ 834, 843 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004110" } ] }, { "id": "858", "type": "Chemical", "text": [ "propafenone" ], "offsets": [ [ 845, 856 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011405" } ] }, { "id": "859", "type": "Chemical", "text": [ "sparteine" ], "offsets": [ [ 908, 917 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013034" } ] }, { "id": "860", "type": "Chemical", "text": [ "debrisoquine" ], "offsets": [ [ 938, 950 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003647" } ] }, { "id": "861", "type": "Chemical", "text": [ "sparteine" ], "offsets": [ [ 951, 960 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013034" } ] }, { "id": "862", "type": "Chemical", "text": [ "sparteine" ], "offsets": [ [ 1208, 1217 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013034" } ] }, { "id": "863", "type": "Chemical", "text": [ "debrisoquine" ], "offsets": [ [ 1218, 1230 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003647" } ] }, { "id": "864", "type": "Disease", "text": [ "adverse drug reactions" ], "offsets": [ [ 1328, 1350 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] } ]

[]

[]

[ { "id": "865", "type": "CID", "arg1_id": "845", "arg2_id": "850", "normalized": [] }, { "id": "866", "type": "CID", "arg1_id": "853", "arg2_id": "850", "normalized": [] }, { "id": "867", "type": "CID", "arg1_id": "855", "arg2_id": "850", "normalized": [] }, { "id": "868", "type": "CID", "arg1_id": "857", "arg2_id": "850", "normalized": [] }, { "id": "869", "type": "CID", "arg1_id": "845", "arg2_id": "851", "normalized": [] }, { "id": "870", "type": "CID", "arg1_id": "853", "arg2_id": "851", "normalized": [] }, { "id": "871", "type": "CID", "arg1_id": "855", "arg2_id": "851", "normalized": [] }, { "id": "872", "type": "CID", "arg1_id": "857", "arg2_id": "851", "normalized": [] }, { "id": "873", "type": "CID", "arg1_id": "843", "arg2_id": "851", "normalized": [] }, { "id": "874", "type": "CID", "arg1_id": "852", "arg2_id": "851", "normalized": [] }, { "id": "875", "type": "CID", "arg1_id": "854", "arg2_id": "851", "normalized": [] }, { "id": "876", "type": "CID", "arg1_id": "856", "arg2_id": "851", "normalized": [] }, { "id": "877", "type": "CID", "arg1_id": "843", "arg2_id": "850", "normalized": [] }, { "id": "878", "type": "CID", "arg1_id": "852", "arg2_id": "850", "normalized": [] }, { "id": "879", "type": "CID", "arg1_id": "854", "arg2_id": "850", "normalized": [] }, { "id": "880", "type": "CID", "arg1_id": "856", "arg2_id": "850", "normalized": [] }, { "id": "881", "type": "CID", "arg1_id": "845", "arg2_id": "849", "normalized": [] }, { "id": "882", "type": "CID", "arg1_id": "853", "arg2_id": "849", "normalized": [] }, { "id": "883", "type": "CID", "arg1_id": "855", "arg2_id": "849", "normalized": [] }, { "id": "884", "type": "CID", "arg1_id": "857", "arg2_id": "849", "normalized": [] }, { "id": "885", "type": "CID", "arg1_id": "843", "arg2_id": "849", "normalized": [] }, { "id": "886", "type": "CID", "arg1_id": "852", "arg2_id": "849", "normalized": [] }, { "id": "887", "type": "CID", "arg1_id": "854", "arg2_id": "849", "normalized": [] }, { "id": "888", "type": "CID", "arg1_id": "856", "arg2_id": "849", "normalized": [] } ]

[ { "id": "890", "type": "title", "text": [ "Triazolam-induced brief episodes of secondary mania in a depressed patient." ], "offsets": [ [ 0, 75 ] ] }, { "id": "891", "type": "abstract", "text": [ "Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is discussed." ], "offsets": [ [ 76, 405 ] ] } ]

[ { "id": "892", "type": "Chemical", "text": [ "Triazolam" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014229" } ] }, { "id": "893", "type": "Disease", "text": [ "mania" ], "offsets": [ [ 46, 51 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "894", "type": "Disease", "text": [ "depressed" ], "offsets": [ [ 57, 66 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "895", "type": "Chemical", "text": [ "triazolam" ], "offsets": [ [ 91, 100 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014229" } ] }, { "id": "896", "type": "Disease", "text": [ "mania" ], "offsets": [ [ 138, 143 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "897", "type": "Disease", "text": [ "depressed" ], "offsets": [ [ 149, 158 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "898", "type": "Disease", "text": [ "organic mental disorder" ], "offsets": [ [ 186, 209 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019965" } ] }, { "id": "899", "type": "Disease", "text": [ "delirium" ], "offsets": [ [ 211, 219 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003693" } ] }, { "id": "900", "type": "Disease", "text": [ "Manic" ], "offsets": [ [ 239, 244 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "901", "type": "Chemical", "text": [ "triazolam" ], "offsets": [ [ 302, 311 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014229" } ] }, { "id": "902", "type": "Chemical", "text": [ "triazolo" ], "offsets": [ [ 346, 354 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014229" } ] } ]

[]

[]

[ { "id": "903", "type": "CID", "arg1_id": "892", "arg2_id": "893", "normalized": [] }, { "id": "904", "type": "CID", "arg1_id": "892", "arg2_id": "896", "normalized": [] }, { "id": "905", "type": "CID", "arg1_id": "892", "arg2_id": "900", "normalized": [] }, { "id": "906", "type": "CID", "arg1_id": "895", "arg2_id": "893", "normalized": [] }, { "id": "907", "type": "CID", "arg1_id": "895", "arg2_id": "896", "normalized": [] }, { "id": "908", "type": "CID", "arg1_id": "895", "arg2_id": "900", "normalized": [] }, { "id": "909", "type": "CID", "arg1_id": "901", "arg2_id": "893", "normalized": [] }, { "id": "910", "type": "CID", "arg1_id": "901", "arg2_id": "896", "normalized": [] }, { "id": "911", "type": "CID", "arg1_id": "901", "arg2_id": "900", "normalized": [] }, { "id": "912", "type": "CID", "arg1_id": "902", "arg2_id": "893", "normalized": [] }, { "id": "913", "type": "CID", "arg1_id": "902", "arg2_id": "896", "normalized": [] }, { "id": "914", "type": "CID", "arg1_id": "902", "arg2_id": "900", "normalized": [] } ]

[ { "id": "916", "type": "title", "text": [ "On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats." ], "offsets": [ [ 0, 104 ] ] }, { "id": "917", "type": "abstract", "text": [ "The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed differences in the development of tolerance: about half of the animals showed a rigidity after the test dose of morphine that was not significantly less than in the controls and were akinetic (A group). The other rats showed a strong decrease in the rigidity and the occurrence of stereotyped (S) licking and/or gnawing in presence of akinetic or hyperkinetic (K) behaviour (AS/KS group), suggesting signs of dopaminergic activation. The rigidity was considerably decreased in both groups after 20 days' treatment. In a further series of experiments, haloperidol (0.2 mg/kg i.p.) was used in order to block the dopaminergic activation and to estimate the real degree of the tolerance to the rigidity without any dopaminergic interference. Haloperidol enhanced the rigidity in the A group. However, the level in the AS/KS group remained considerably lower than in the A group. The results suggest that rigidity, which is assumed to be due to an action of morphine in the striatum, can be antagonized by another process leading to dopaminergic activation in the striatum. Nevertheless, there occurs some real tolerance to this effect. The rapid alternations of rigidity and the signs of dopaminergic activation observed in the animals of the AS/KS group might be due to rapid shifts in the predominance of various DA-innervated structures." ], "offsets": [ [ 105, 1762 ] ] } ]

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[]

[]

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"926", "arg2_id": "938", "normalized": [] }, { "id": "1009", "type": "CID", "arg1_id": "937", "arg2_id": "918", "normalized": [] }, { "id": "1010", "type": "CID", "arg1_id": "937", "arg2_id": "920", "normalized": [] }, { "id": "1011", "type": "CID", "arg1_id": "937", "arg2_id": "923", "normalized": [] }, { "id": "1012", "type": "CID", "arg1_id": "937", "arg2_id": "925", "normalized": [] }, { "id": "1013", "type": "CID", "arg1_id": "937", "arg2_id": "928", "normalized": [] }, { "id": "1014", "type": "CID", "arg1_id": "937", "arg2_id": "931", "normalized": [] }, { "id": "1015", "type": "CID", "arg1_id": "937", "arg2_id": "933", "normalized": [] }, { "id": "1016", "type": "CID", "arg1_id": "937", "arg2_id": "935", "normalized": [] }, { "id": "1017", "type": "CID", "arg1_id": "937", "arg2_id": "936", "normalized": [] }, { "id": "1018", "type": "CID", "arg1_id": "937", "arg2_id": "938", "normalized": [] }, { "id": "1019", "type": "CID", "arg1_id": "919", "arg2_id": "930", "normalized": [] }, { "id": "1020", "type": "CID", "arg1_id": "921", "arg2_id": "930", "normalized": [] }, { "id": "1021", "type": "CID", "arg1_id": "922", "arg2_id": "930", "normalized": [] }, { "id": "1022", "type": "CID", "arg1_id": "924", "arg2_id": "930", "normalized": [] }, { "id": "1023", "type": "CID", "arg1_id": "926", "arg2_id": "930", "normalized": [] }, { "id": "1024", "type": "CID", "arg1_id": "937", "arg2_id": "930", "normalized": [] }, { "id": "1025", "type": "CID", "arg1_id": "919", "arg2_id": "927", "normalized": [] }, { "id": "1026", "type": "CID", "arg1_id": "919", "arg2_id": "929", "normalized": [] }, { "id": "1027", "type": "CID", "arg1_id": "921", "arg2_id": "927", "normalized": [] }, { "id": "1028", "type": "CID", "arg1_id": "921", "arg2_id": "929", "normalized": [] }, { "id": "1029", "type": "CID", "arg1_id": "922", "arg2_id": "927", "normalized": [] }, { "id": "1030", "type": "CID", "arg1_id": "922", "arg2_id": "929", "normalized": [] }, { "id": "1031", "type": "CID", "arg1_id": "924", "arg2_id": "927", "normalized": [] }, { "id": "1032", "type": "CID", "arg1_id": "924", "arg2_id": "929", "normalized": [] }, { "id": "1033", "type": "CID", "arg1_id": "926", "arg2_id": "927", "normalized": [] }, { "id": "1034", "type": "CID", "arg1_id": "926", "arg2_id": "929", "normalized": [] }, { "id": "1035", "type": "CID", "arg1_id": "937", "arg2_id": "927", "normalized": [] }, { "id": "1036", "type": "CID", "arg1_id": "937", "arg2_id": "929", "normalized": [] } ]

[ { "id": "1038", "type": "title", "text": [ "Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy." ], "offsets": [ [ 0, 87 ] ] }, { "id": "1039", "type": "abstract", "text": [ "Fibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy has not previously been reported. In a 37-year-old woman with documented pentazocine-induced fibrous myopathy of triceps and deltoid muscles bilaterally and a three-week history of right wrist drop, electrodiagnostic examination showed a severe but partial lesion of the right radial nerve distal to the branches to the triceps, in addition to the fibrous myopathy. Surgery revealed the right radial nerve to be severely compressed by the densely fibrotic lateral head of the triceps. Decompression and neurolysis were performed with good subsequent recovery of function." ], "offsets": [ [ 88, 843 ] ] } ]

[ { "id": "1040", "type": "Disease", "text": [ "Compression neuropathy of the radial nerve" ], "offsets": [ [ 0, 42 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009408" }, { "db_name": "MESH", "db_id": "D020425" } ] }, { "id": "1041", "type": "Disease", "text": [ "Compression neuropathy" ], "offsets": [ [ 0, 22 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009408" } ] }, { "id": "1042", "type": "Disease", "text": [ "neuropathy of the radial nerve" ], "offsets": [ [ 12, 42 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020425" } ] }, { "id": "1043", "type": "Chemical", "text": [ "pentazocine" ], "offsets": [ [ 50, 61 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010423" } ] }, { "id": "1044", "type": "Disease", "text": [ "fibrous myopathy" ], "offsets": [ [ 70, 86 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005355" }, { "db_name": "MESH", "db_id": "D009135" } ] }, { "id": "1045", "type": "Disease", "text": [ "Fibrous myopathy" ], "offsets": [ [ 88, 104 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005355" }, { "db_name": "MESH", "db_id": "D009135" } ] }, { "id": "1046", "type": "Chemical", "text": [ "pentazocine" ], "offsets": [ [ 153, 164 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010423" } ] }, { "id": "1047", "type": "Disease", "text": [ "compression neuropathy" ], "offsets": [ [ 185, 207 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009408" } ] }, { "id": "1048", "type": "Chemical", "text": [ "pentazocine" ], "offsets": [ [ 243, 254 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010423" } ] }, { "id": "1049", "type": "Disease", "text": [ "myopathy" ], "offsets": [ [ 263, 271 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009135" } ] }, { "id": "1050", "type": "Chemical", "text": [ "pentazocine" ], "offsets": [ [ 345, 356 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010423" } ] }, { "id": "1051", "type": "Disease", "text": [ "fibrous myopathy" ], "offsets": [ [ 365, 381 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005355" }, { "db_name": "MESH", "db_id": "D009135" } ] }, { "id": "1052", "type": "Disease", "text": [ "fibrous myopathy" ], "offsets": [ [ 620, 636 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005355" }, { "db_name": "MESH", "db_id": "D009135" } ] } ]

[]

[]

[ { "id": "1053", "type": "CID", "arg1_id": "1043", "arg2_id": "1044", "normalized": [] }, { "id": "1054", "type": "CID", "arg1_id": "1043", "arg2_id": "1045", "normalized": [] }, { "id": "1055", "type": "CID", "arg1_id": "1043", "arg2_id": "1051", "normalized": [] }, { "id": "1056", "type": "CID", "arg1_id": "1043", "arg2_id": "1052", "normalized": [] }, { "id": "1057", "type": "CID", "arg1_id": "1046", "arg2_id": "1044", "normalized": [] }, { "id": "1058", "type": "CID", "arg1_id": "1046", "arg2_id": "1045", "normalized": [] }, { "id": "1059", "type": "CID", "arg1_id": "1046", "arg2_id": "1051", "normalized": [] }, { "id": "1060", "type": "CID", "arg1_id": "1046", "arg2_id": "1052", "normalized": [] }, { "id": "1061", "type": "CID", "arg1_id": "1048", "arg2_id": "1044", "normalized": [] }, { "id": "1062", "type": "CID", "arg1_id": "1048", "arg2_id": "1045", "normalized": [] }, { "id": "1063", "type": "CID", "arg1_id": "1048", "arg2_id": "1051", "normalized": [] }, { "id": "1064", "type": "CID", "arg1_id": "1048", "arg2_id": "1052", "normalized": [] }, { "id": "1065", "type": "CID", "arg1_id": "1050", "arg2_id": "1044", "normalized": [] }, { "id": "1066", "type": "CID", "arg1_id": "1050", "arg2_id": "1045", "normalized": [] }, { "id": "1067", "type": "CID", "arg1_id": "1050", "arg2_id": "1051", "normalized": [] }, { "id": "1068", "type": "CID", "arg1_id": "1050", "arg2_id": "1052", "normalized": [] }, { "id": "1069", "type": "CID", "arg1_id": "1043", "arg2_id": "1044", "normalized": [] }, { "id": "1070", "type": "CID", "arg1_id": "1043", "arg2_id": "1045", "normalized": [] }, { "id": "1071", "type": "CID", "arg1_id": "1043", "arg2_id": "1049", "normalized": [] }, { "id": "1072", "type": "CID", "arg1_id": "1043", "arg2_id": "1051", "normalized": [] }, { "id": "1073", "type": "CID", "arg1_id": "1043", "arg2_id": "1052", "normalized": [] }, { "id": "1074", "type": "CID", "arg1_id": "1046", "arg2_id": "1044", "normalized": [] }, { "id": "1075", "type": "CID", "arg1_id": "1046", "arg2_id": "1045", "normalized": [] }, { "id": "1076", "type": "CID", "arg1_id": "1046", "arg2_id": "1049", "normalized": [] }, { "id": "1077", "type": "CID", "arg1_id": "1046", "arg2_id": "1051", "normalized": [] }, { "id": "1078", "type": "CID", "arg1_id": "1046", "arg2_id": "1052", "normalized": [] }, { "id": "1079", "type": "CID", "arg1_id": "1048", "arg2_id": "1044", "normalized": [] }, { "id": "1080", "type": "CID", "arg1_id": "1048", "arg2_id": "1045", "normalized": [] }, { "id": "1081", "type": "CID", "arg1_id": "1048", "arg2_id": "1049", "normalized": [] }, { "id": "1082", "type": "CID", "arg1_id": "1048", "arg2_id": "1051", "normalized": [] }, { "id": "1083", "type": "CID", "arg1_id": "1048", "arg2_id": "1052", "normalized": [] }, { "id": "1084", "type": "CID", "arg1_id": "1050", "arg2_id": "1044", "normalized": [] }, { "id": "1085", "type": "CID", "arg1_id": "1050", "arg2_id": "1045", "normalized": [] }, { "id": "1086", "type": "CID", "arg1_id": "1050", "arg2_id": "1049", "normalized": [] }, { "id": "1087", "type": "CID", "arg1_id": "1050", "arg2_id": "1051", "normalized": [] }, { "id": "1088", "type": "CID", "arg1_id": "1050", "arg2_id": "1052", "normalized": [] }, { "id": "1089", "type": "CID", "arg1_id": "1043", "arg2_id": "1040", "normalized": [] }, { "id": "1090", "type": "CID", "arg1_id": "1043", "arg2_id": "1042", "normalized": [] }, { "id": "1091", "type": "CID", "arg1_id": "1046", "arg2_id": "1040", "normalized": [] }, { "id": "1092", "type": "CID", "arg1_id": "1046", "arg2_id": "1042", "normalized": [] }, { "id": "1093", "type": "CID", "arg1_id": "1048", "arg2_id": "1040", "normalized": [] }, { "id": "1094", "type": "CID", "arg1_id": "1048", "arg2_id": "1042", "normalized": [] }, { "id": "1095", "type": "CID", "arg1_id": "1050", "arg2_id": "1040", "normalized": [] }, { "id": "1096", "type": "CID", "arg1_id": "1050", "arg2_id": "1042", "normalized": [] }, { "id": "1097", "type": "CID", "arg1_id": "1043", "arg2_id": "1040", "normalized": [] }, { "id": "1098", "type": "CID", "arg1_id": "1043", "arg2_id": "1041", "normalized": [] }, { "id": "1099", "type": "CID", "arg1_id": "1043", "arg2_id": "1047", "normalized": [] }, { "id": "1100", "type": "CID", "arg1_id": "1046", "arg2_id": "1040", "normalized": [] }, { "id": "1101", "type": "CID", "arg1_id": "1046", "arg2_id": "1041", "normalized": [] }, { "id": "1102", "type": "CID", "arg1_id": "1046", "arg2_id": "1047", "normalized": [] }, { "id": "1103", "type": "CID", "arg1_id": "1048", "arg2_id": "1040", "normalized": [] }, { "id": "1104", "type": "CID", "arg1_id": "1048", "arg2_id": "1041", "normalized": [] }, { "id": "1105", "type": "CID", "arg1_id": "1048", "arg2_id": "1047", "normalized": [] }, { "id": "1106", "type": "CID", "arg1_id": "1050", "arg2_id": "1040", "normalized": [] }, { "id": "1107", "type": "CID", "arg1_id": "1050", "arg2_id": "1041", "normalized": [] }, { "id": "1108", "type": "CID", "arg1_id": "1050", "arg2_id": "1047", "normalized": [] } ]

[ { "id": "1110", "type": "title", "text": [ "Recurrent reversible acute renal failure from amphotericin." ], "offsets": [ [ 0, 59 ] ] }, { "id": "1111", "type": "abstract", "text": [ "A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysfunction. We propose that amphotericin, in the setting of reduced effective arterial volume, may activate tubuloglomerular feedback, thereby contributing to acute renal failure." ], "offsets": [ [ 60, 556 ] ] } ]

[ { "id": "1112", "type": "Disease", "text": [ "acute renal failure" ], "offsets": [ [ 21, 40 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D058186" } ] }, { "id": "1113", "type": "Chemical", "text": [ "amphotericin" ], "offsets": [ [ 46, 58 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000666" } ] }, { "id": "1114", "type": "Disease", "text": [ "cirrhosis" ], "offsets": [ [ 87, 96 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005355" } ] }, { "id": "1115", "type": "Disease", "text": [ "sporotrichosis" ], "offsets": [ [ 114, 128 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013174" } ] }, { "id": "1116", "type": "Disease", "text": [ "acute renal failure" ], "offsets": [ [ 139, 158 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D058186" } ] }, { "id": "1117", "type": "Chemical", "text": [ "amphotericin B" ], "offsets": [ [ 203, 217 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000666" } ] }, { "id": "1118", "type": "Disease", "text": [ "renal failure" ], "offsets": [ [ 268, 281 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "1119", "type": "Disease", "text": [ "renal dysfunction" ], "offsets": [ [ 370, 387 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "1120", "type": "Chemical", "text": [ "amphotericin" ], "offsets": [ [ 405, 417 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000666" } ] }, { "id": "1121", "type": "Disease", "text": [ "acute renal failure" ], "offsets": [ [ 536, 555 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D058186" } ] } ]

[]

[]

[ { "id": "1122", "type": "CID", "arg1_id": "1113", "arg2_id": "1112", "normalized": [] }, { "id": "1123", "type": "CID", "arg1_id": "1113", "arg2_id": "1116", "normalized": [] }, { "id": "1124", "type": "CID", "arg1_id": "1113", "arg2_id": "1121", "normalized": [] }, { "id": "1125", "type": "CID", "arg1_id": "1117", "arg2_id": "1112", "normalized": [] }, { "id": "1126", "type": "CID", "arg1_id": "1117", "arg2_id": "1116", "normalized": [] }, { "id": "1127", "type": "CID", "arg1_id": "1117", "arg2_id": "1121", "normalized": [] }, { "id": "1128", "type": "CID", "arg1_id": "1120", "arg2_id": "1112", "normalized": [] }, { "id": "1129", "type": "CID", "arg1_id": "1120", "arg2_id": "1116", "normalized": [] }, { "id": "1130", "type": "CID", "arg1_id": "1120", "arg2_id": "1121", "normalized": [] } ]

[ { "id": "1132", "type": "title", "text": [ "Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy." ], "offsets": [ [ 0, 91 ] ] }, { "id": "1133", "type": "abstract", "text": [ "A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immediate but gradual improvement followed withdrawal of amiodarone and treatment with prednisolone. Review of this and previously reported cases indicates the need for early diagnosis of amiodarone pneumonitis, immediate withdrawal of amiodarone, and prompt but continued steroid therapy to ensure full recovery." ], "offsets": [ [ 92, 718 ] ] } ]

[ { "id": "1134", "type": "Disease", "text": [ "pleural and pericardial effusion" ], "offsets": [ [ 17, 49 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010996" }, { "db_name": "MESH", "db_id": "D010490" } ] }, { "id": "1135", "type": "Disease", "text": [ "pleural", "effusion" ], "offsets": [ [ 17, 24 ], [ 41, 49 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010996" } ] }, { "id": "1136", "type": "Disease", "text": [ "pericardial effusion" ], "offsets": [ [ 29, 49 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010490" } ] }, { "id": "1137", "type": "Disease", "text": [ "neuropathy" ], "offsets": [ [ 54, 64 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] }, { "id": "1138", "type": "Chemical", "text": [ "amiodarone" ], "offsets": [ [ 72, 82 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000638" } ] }, { "id": "1139", "type": "Disease", "text": [ "sinuatrial disease" ], "offsets": [ [ 107, 125 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002318" } ] }, { "id": "1140", "type": "Chemical", "text": [ "amiodarone" ], "offsets": [ [ 167, 177 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000638" } ] }, { "id": "1141", "type": "Disease", "text": [ "supraventricular tachyarrhythmias" ], "offsets": [ [ 262, 295 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013617" } ] }, { "id": "1142", "type": "Disease", "text": [ "pneumonitis" ], "offsets": [ [ 310, 321 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011014" } ] }, { "id": "1143", "type": "Disease", "text": [ "pleural and pericardial effusions" ], "offsets": [ [ 323, 356 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010996" }, { "db_name": "MESH", "db_id": "D010490" } ] }, { "id": "1144", "type": "Disease", "text": [ "pleural", "effusions" ], "offsets": [ [ 323, 330 ], [ 347, 356 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010996" } ] }, { "id": "1145", "type": "Disease", "text": [ "pericardial effusions" ], "offsets": [ [ 335, 356 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010490" } ] }, { "id": "1146", "type": "Disease", "text": [ "proximal motor neuropathy" ], "offsets": [ [ 378, 403 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009468" } ] }, { "id": "1147", "type": "Chemical", "text": [ "amiodarone" ], "offsets": [ [ 462, 472 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000638" } ] }, { "id": "1148", "type": "Chemical", "text": [ "prednisolone" ], "offsets": [ [ 492, 504 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011239" } ] }, { "id": "1149", "type": "Chemical", "text": [ "amiodarone" ], "offsets": [ [ 593, 603 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000638" } ] }, { "id": "1150", "type": "Disease", "text": [ "pneumonitis" ], "offsets": [ [ 604, 615 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011014" } ] }, { "id": "1151", "type": "Chemical", "text": [ "amiodarone" ], "offsets": [ [ 641, 651 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000638" } ] }, { "id": "1152", "type": "Chemical", "text": [ "steroid" ], "offsets": [ [ 678, 685 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013256" } ] } ]

[]

[]

[ { "id": "1153", "type": "CID", "arg1_id": "1138", "arg2_id": "1134", "normalized": [] }, { "id": "1154", "type": "CID", "arg1_id": "1138", "arg2_id": "1136", "normalized": [] }, { "id": "1155", "type": "CID", "arg1_id": "1138", "arg2_id": "1143", "normalized": [] }, { "id": "1156", "type": "CID", "arg1_id": "1138", "arg2_id": "1145", "normalized": [] }, { "id": "1157", "type": "CID", "arg1_id": "1140", "arg2_id": "1134", "normalized": [] }, { "id": "1158", "type": "CID", "arg1_id": "1140", "arg2_id": "1136", "normalized": [] }, { "id": "1159", "type": "CID", "arg1_id": "1140", "arg2_id": "1143", "normalized": [] }, { "id": "1160", "type": "CID", "arg1_id": "1140", "arg2_id": "1145", "normalized": [] }, { "id": "1161", "type": "CID", "arg1_id": "1147", "arg2_id": "1134", "normalized": [] }, { "id": "1162", "type": "CID", "arg1_id": "1147", "arg2_id": "1136", "normalized": [] }, { "id": "1163", "type": "CID", "arg1_id": "1147", "arg2_id": "1143", "normalized": [] }, { "id": "1164", "type": "CID", "arg1_id": "1147", "arg2_id": "1145", "normalized": [] }, { "id": "1165", "type": "CID", "arg1_id": "1149", "arg2_id": "1134", "normalized": [] }, { "id": "1166", "type": "CID", "arg1_id": "1149", "arg2_id": "1136", "normalized": [] }, { "id": "1167", "type": "CID", "arg1_id": "1149", "arg2_id": "1143", "normalized": [] }, { "id": "1168", "type": "CID", "arg1_id": "1149", "arg2_id": "1145", "normalized": [] }, { "id": "1169", "type": "CID", "arg1_id": "1151", "arg2_id": "1134", "normalized": [] }, { "id": "1170", "type": "CID", "arg1_id": "1151", "arg2_id": "1136", "normalized": [] }, { "id": "1171", "type": "CID", "arg1_id": "1151", "arg2_id": "1143", "normalized": [] }, { "id": "1172", "type": "CID", "arg1_id": "1151", "arg2_id": "1145", "normalized": [] }, { "id": "1173", "type": "CID", "arg1_id": "1138", "arg2_id": "1146", "normalized": [] }, { "id": "1174", "type": "CID", "arg1_id": "1140", "arg2_id": "1146", "normalized": [] }, { "id": "1175", "type": "CID", "arg1_id": "1147", "arg2_id": "1146", "normalized": [] }, { "id": "1176", "type": "CID", "arg1_id": "1149", "arg2_id": "1146", "normalized": [] }, { "id": "1177", "type": "CID", "arg1_id": "1151", "arg2_id": "1146", "normalized": [] }, { "id": "1178", "type": "CID", "arg1_id": "1138", "arg2_id": "1134", "normalized": [] }, { "id": "1179", "type": "CID", "arg1_id": "1138", "arg2_id": "1135", "normalized": [] }, { "id": "1180", "type": "CID", "arg1_id": "1138", "arg2_id": "1143", "normalized": [] }, { "id": "1181", "type": "CID", "arg1_id": "1138", "arg2_id": "1144", "normalized": [] }, { "id": "1182", "type": "CID", "arg1_id": "1140", "arg2_id": "1134", "normalized": [] }, { "id": "1183", "type": "CID", "arg1_id": "1140", "arg2_id": "1135", "normalized": [] }, { "id": "1184", "type": "CID", "arg1_id": "1140", "arg2_id": "1143", "normalized": [] }, { "id": "1185", "type": "CID", "arg1_id": "1140", "arg2_id": "1144", "normalized": [] }, { "id": "1186", "type": "CID", "arg1_id": "1147", "arg2_id": "1134", "normalized": [] }, { "id": "1187", "type": "CID", "arg1_id": "1147", "arg2_id": "1135", "normalized": [] }, { "id": "1188", "type": "CID", "arg1_id": "1147", "arg2_id": "1143", "normalized": [] }, { "id": "1189", "type": "CID", "arg1_id": "1147", "arg2_id": "1144", "normalized": [] }, { "id": "1190", "type": "CID", "arg1_id": "1149", "arg2_id": "1134", "normalized": [] }, { "id": "1191", "type": "CID", "arg1_id": "1149", "arg2_id": "1135", "normalized": [] }, { "id": "1192", "type": "CID", "arg1_id": "1149", "arg2_id": "1143", "normalized": [] }, { "id": "1193", "type": "CID", "arg1_id": "1149", "arg2_id": "1144", "normalized": [] }, { "id": "1194", "type": "CID", "arg1_id": "1151", "arg2_id": "1134", "normalized": [] }, { "id": "1195", "type": "CID", "arg1_id": "1151", "arg2_id": "1135", "normalized": [] }, { "id": "1196", "type": "CID", "arg1_id": "1151", "arg2_id": "1143", "normalized": [] }, { "id": "1197", "type": "CID", "arg1_id": "1151", "arg2_id": "1144", "normalized": [] }, { "id": "1198", "type": "CID", "arg1_id": "1138", "arg2_id": "1142", "normalized": [] }, { "id": "1199", "type": "CID", "arg1_id": "1138", "arg2_id": "1150", "normalized": [] }, { "id": "1200", "type": "CID", "arg1_id": "1140", "arg2_id": "1142", "normalized": [] }, { "id": "1201", "type": "CID", "arg1_id": "1140", "arg2_id": "1150", "normalized": [] }, { "id": "1202", "type": "CID", "arg1_id": "1147", "arg2_id": "1142", "normalized": [] }, { "id": "1203", "type": "CID", "arg1_id": "1147", "arg2_id": "1150", "normalized": [] }, { "id": "1204", "type": "CID", "arg1_id": "1149", "arg2_id": "1142", "normalized": [] }, { "id": "1205", "type": "CID", "arg1_id": "1149", "arg2_id": "1150", "normalized": [] }, { "id": "1206", "type": "CID", "arg1_id": "1151", "arg2_id": "1142", "normalized": [] }, { "id": "1207", "type": "CID", "arg1_id": "1151", "arg2_id": "1150", "normalized": [] } ]

[ { "id": "1209", "type": "title", "text": [ "Indomethacin-induced renal insufficiency: recurrence on rechallenge." ], "offsets": [ [ 0, 68 ] ] }, { "id": "1210", "type": "abstract", "text": [ "We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. Our case supports the hypothesis that endogenous renal prostaglandins play a role in the maintenance of renal blood flow when circulating plasma volume is diminished. Since nonsteroidal anti-inflammatory agents interfere with this compensatory mechanism and may cause acute renal failure, they should be used with caution in such patients." ], "offsets": [ [ 69, 728 ] ] } ]

[ { "id": "1211", "type": "Chemical", "text": [ "Indomethacin" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007213" } ] }, { "id": "1212", "type": "Disease", "text": [ "renal insufficiency" ], "offsets": [ [ 21, 40 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "1213", "type": "Disease", "text": [ "renal failure" ], "offsets": [ [ 111, 124 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "1214", "type": "Disease", "text": [ "hyperkalemia" ], "offsets": [ [ 130, 142 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006947" } ] }, { "id": "1215", "type": "Disease", "text": [ "cirrhosis" ], "offsets": [ [ 161, 170 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005355" } ] }, { "id": "1216", "type": "Disease", "text": [ "ascites" ], "offsets": [ [ 172, 179 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001201" } ] }, { "id": "1217", "type": "Disease", "text": [ "cor pulmonale" ], "offsets": [ [ 185, 198 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011660" } ] }, { "id": "1218", "type": "Chemical", "text": [ "indomethacin" ], "offsets": [ [ 205, 217 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007213" } ] }, { "id": "1219", "type": "Chemical", "text": [ "indomethacin" ], "offsets": [ [ 328, 340 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007213" } ] }, { "id": "1220", "type": "Disease", "text": [ "oliguria" ], "offsets": [ [ 379, 387 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009846" } ] }, { "id": "1221", "type": "Chemical", "text": [ "prostaglandins" ], "offsets": [ [ 444, 458 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011453" } ] }, { "id": "1222", "type": "Disease", "text": [ "acute renal failure" ], "offsets": [ [ 657, 676 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D058186" } ] } ]

[]

[]

[ { "id": "1223", "type": "CID", "arg1_id": "1211", "arg2_id": "1214", "normalized": [] }, { "id": "1224", "type": "CID", "arg1_id": "1218", "arg2_id": "1214", "normalized": [] }, { "id": "1225", "type": "CID", "arg1_id": "1219", "arg2_id": "1214", "normalized": [] }, { "id": "1226", "type": "CID", "arg1_id": "1211", "arg2_id": "1220", "normalized": [] }, { "id": "1227", "type": "CID", "arg1_id": "1218", "arg2_id": "1220", "normalized": [] }, { "id": "1228", "type": "CID", "arg1_id": "1219", "arg2_id": "1220", "normalized": [] }, { "id": "1229", "type": "CID", "arg1_id": "1211", "arg2_id": "1222", "normalized": [] }, { "id": "1230", "type": "CID", "arg1_id": "1218", "arg2_id": "1222", "normalized": [] }, { "id": "1231", "type": "CID", "arg1_id": "1219", "arg2_id": "1222", "normalized": [] }, { "id": "1232", "type": "CID", "arg1_id": "1211", "arg2_id": "1215", "normalized": [] }, { "id": "1233", "type": "CID", "arg1_id": "1218", "arg2_id": "1215", "normalized": [] }, { "id": "1234", "type": "CID", "arg1_id": "1219", "arg2_id": "1215", "normalized": [] }, { "id": "1235", "type": "CID", "arg1_id": "1211", "arg2_id": "1216", "normalized": [] }, { "id": "1236", "type": "CID", "arg1_id": "1218", "arg2_id": "1216", "normalized": [] }, { "id": "1237", "type": "CID", "arg1_id": "1219", "arg2_id": "1216", "normalized": [] }, { "id": "1238", "type": "CID", "arg1_id": "1211", "arg2_id": "1217", "normalized": [] }, { "id": "1239", "type": "CID", "arg1_id": "1218", "arg2_id": "1217", "normalized": [] }, { "id": "1240", "type": "CID", "arg1_id": "1219", "arg2_id": "1217", "normalized": [] } ]

[ { "id": "1242", "type": "title", "text": [ "Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in volunteers." ], "offsets": [ [ 0, 133 ] ] }, { "id": "1243", "type": "abstract", "text": [ "Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas-liquid chromatography, in a smaller number of the subjects. The most striking effect was sedation which increased with the dose, 2 mg producing deep sleep although the subjects could still be aroused. The effects of i.m. administration were apparent earlier and sometimes lasted longer than those following oral administration. Dizziness was less marked than sedation, but increased with the dose. There was pain on i.m. injection of flunitrazepam significantly more often than with isotonic saline. Plasma concentrations varied with dose and route and corresponded qualitatively with the subjective effects. The drug was still present in measurable quantities after 24 h even with the smallest dose." ], "offsets": [ [ 134, 1010 ] ] } ]

[ { "id": "1244", "type": "Chemical", "text": [ "flunitrazepam" ], "offsets": [ [ 105, 118 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005445" } ] }, { "id": "1245", "type": "Chemical", "text": [ "Flunitrazepam" ], "offsets": [ [ 134, 147 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005445" } ] }, { "id": "1246", "type": "Disease", "text": [ "Dizziness" ], "offsets": [ [ 638, 647 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004244" } ] }, { "id": "1247", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 718, 722 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010146" } ] }, { "id": "1248", "type": "Chemical", "text": [ "flunitrazepam" ], "offsets": [ [ 744, 757 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005445" } ] } ]

[]

[]

[ { "id": "1249", "type": "CID", "arg1_id": "1244", "arg2_id": "1246", "normalized": [] }, { "id": "1250", "type": "CID", "arg1_id": "1245", "arg2_id": "1246", "normalized": [] }, { "id": "1251", "type": "CID", "arg1_id": "1248", "arg2_id": "1246", "normalized": [] }, { "id": "1252", "type": "CID", "arg1_id": "1244", "arg2_id": "1247", "normalized": [] }, { "id": "1253", "type": "CID", "arg1_id": "1245", "arg2_id": "1247", "normalized": [] }, { "id": "1254", "type": "CID", "arg1_id": "1248", "arg2_id": "1247", "normalized": [] } ]

[ { "id": "1256", "type": "title", "text": [ "Changes in heart size during long-term timolol treatment after myocardial infarction." ], "offsets": [ [ 0, 85 ] ] }, { "id": "1257", "type": "abstract", "text": [ "The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-treated patients showed a small but significant increase in heart size from baseline in contrast to a decrease in the placebo group. These differences may be caused by timolol-induced bradycardia and a compensatory increase in end-diastolic volume. The timolol-related increase in heart size was observed only in patients with normal and borderline heart size. In patients with cardiomegaly, the increase in heart size was similar in both groups. After re-infarction, heart size increased in the placebo group and remained unchanged in the timolol group." ], "offsets": [ [ 86, 870 ] ] } ]

[ { "id": "1258", "type": "Chemical", "text": [ "timolol" ], "offsets": [ [ 39, 46 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013999" } ] }, { "id": "1259", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 63, 84 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "1260", "type": "Chemical", "text": [ "timolol" ], "offsets": [ [ 110, 117 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013999" } ] }, { "id": "1261", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 148, 169 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "1262", "type": "Chemical", "text": [ "timolol" ], "offsets": [ [ 254, 261 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013999" } ] }, { "id": "1263", "type": "Chemical", "text": [ "timolol" ], "offsets": [ [ 308, 315 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013999" } ] }, { "id": "1264", "type": "Chemical", "text": [ "timolol" ], "offsets": [ [ 484, 491 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013999" } ] }, { "id": "1265", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 500, 511 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "1266", "type": "Chemical", "text": [ "timolol" ], "offsets": [ [ 569, 576 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013999" } ] }, { "id": "1267", "type": "Disease", "text": [ "cardiomegaly" ], "offsets": [ [ 694, 706 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006332" } ] }, { "id": "1268", "type": "Disease", "text": [ "infarction" ], "offsets": [ [ 772, 782 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007238" } ] }, { "id": "1269", "type": "Chemical", "text": [ "timolol" ], "offsets": [ [ 856, 863 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013999" } ] } ]

[]

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[ { "id": "1270", "type": "CID", "arg1_id": "1258", "arg2_id": "1267", "normalized": [] }, { "id": "1271", "type": "CID", "arg1_id": "1260", "arg2_id": "1267", "normalized": [] }, { "id": "1272", "type": "CID", "arg1_id": "1262", "arg2_id": "1267", "normalized": [] }, { "id": "1273", "type": "CID", "arg1_id": "1263", "arg2_id": "1267", "normalized": [] }, { "id": "1274", "type": "CID", "arg1_id": "1264", "arg2_id": "1267", "normalized": [] }, { "id": "1275", "type": "CID", "arg1_id": "1266", "arg2_id": "1267", "normalized": [] }, { "id": "1276", "type": "CID", "arg1_id": "1269", "arg2_id": "1267", "normalized": [] } ]

[ { "id": "1278", "type": "title", "text": [ "Vitamin D3 toxicity in dairy cows." ], "offsets": [ [ 0, 34 ] ] }, { "id": "1279", "type": "abstract", "text": [ "Large parenteral doses of vitamin D3 (15 to 17.5 x 10(6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its metabolites in the blood plasma of nonlactating nonpregnant and pregnant Jersey cows. Calcium concentrations 1 day postpartum were higher in cows treated with vitamin D3 about 32 days prepartum (8.8 mg/100 ml) than in control cows (5.5 mg/100 ml). None of the cows treated with vitamin D3 showed signs of milk fever during the peripartal period; however, 22% of the control cows developed clinical signs of milk fever during this period. Signs of vitamin D3 toxicity were not observed in nonlactating nonpregnant cows; however, pregnant cows commonly developed severe signs of vitamin D3 toxicity and 10 of 17 cows died. There was widespread metastatic calcification in the cows that died. Because of the extreme toxicity of vitamin D3 in pregnant Jersey cows and the low margin of safety between doses of vitamin D3 that prevent milk fever and doses that induce milk fever, we concluded that vitamin D3 cannot be used practically to prevent milk fever when injected several weeks prepartum." ], "offsets": [ [ 35, 1205 ] ] } ]

[ { "id": "1280", "type": "Chemical", "text": [ "Vitamin D3" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1281", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 11, 19 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "1282", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 61, 71 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1283", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 95, 105 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1284", "type": "Disease", "text": [ "hypercalcemia" ], "offsets": [ [ 138, 151 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006934" } ] }, { "id": "1285", "type": "Disease", "text": [ "hyperphosphatemia" ], "offsets": [ [ 153, 170 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054559" } ] }, { "id": "1286", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 195, 205 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1287", "type": "Chemical", "text": [ "Calcium" ], "offsets": [ [ 300, 307 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002118" } ] }, { "id": "1288", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 373, 383 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1289", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 492, 502 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1290", "type": "Disease", "text": [ "milk fever" ], "offsets": [ [ 519, 529 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010319" } ] }, { "id": "1291", "type": "Disease", "text": [ "milk fever" ], "offsets": [ [ 621, 631 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010319" } ] }, { "id": "1292", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 661, 671 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1293", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 672, 680 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "1294", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 791, 801 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1295", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 802, 810 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "1296", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 927, 935 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "1297", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 939, 949 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1298", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 1020, 1030 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1299", "type": "Disease", "text": [ "milk fever" ], "offsets": [ [ 1044, 1054 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010319" } ] }, { "id": "1300", "type": "Disease", "text": [ "milk fever" ], "offsets": [ [ 1077, 1087 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010319" } ] }, { "id": "1301", "type": "Chemical", "text": [ "vitamin D3" ], "offsets": [ [ 1107, 1117 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002762" } ] }, { "id": "1302", "type": "Disease", "text": [ "milk fever" ], "offsets": [ [ 1156, 1166 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010319" } ] } ]

[]

[]

[ { "id": "1303", "type": "CID", "arg1_id": "1280", "arg2_id": "1284", "normalized": [] }, { "id": "1304", "type": "CID", "arg1_id": "1282", "arg2_id": "1284", "normalized": [] }, { "id": "1305", "type": "CID", "arg1_id": "1283", "arg2_id": "1284", "normalized": [] }, { "id": "1306", "type": "CID", "arg1_id": "1286", "arg2_id": "1284", "normalized": [] }, { "id": "1307", "type": "CID", "arg1_id": "1288", "arg2_id": "1284", "normalized": [] }, { "id": "1308", "type": "CID", "arg1_id": "1289", "arg2_id": "1284", "normalized": [] }, { "id": "1309", "type": "CID", "arg1_id": "1292", "arg2_id": "1284", "normalized": [] }, { "id": "1310", "type": "CID", "arg1_id": "1294", "arg2_id": "1284", "normalized": [] }, { "id": "1311", "type": "CID", "arg1_id": "1297", "arg2_id": "1284", "normalized": [] }, { "id": "1312", "type": "CID", "arg1_id": "1298", "arg2_id": "1284", "normalized": [] }, { "id": "1313", "type": "CID", "arg1_id": "1301", "arg2_id": "1284", "normalized": [] }, { "id": "1314", "type": "CID", "arg1_id": "1280", "arg2_id": "1285", "normalized": [] }, { "id": "1315", "type": "CID", "arg1_id": "1282", "arg2_id": "1285", "normalized": [] }, { "id": "1316", "type": "CID", "arg1_id": "1283", "arg2_id": "1285", "normalized": [] }, { "id": "1317", "type": "CID", "arg1_id": "1286", "arg2_id": "1285", "normalized": [] }, { "id": "1318", "type": "CID", "arg1_id": "1288", "arg2_id": "1285", "normalized": [] }, { "id": "1319", "type": "CID", "arg1_id": "1289", "arg2_id": "1285", "normalized": [] }, { "id": "1320", "type": "CID", "arg1_id": "1292", "arg2_id": "1285", "normalized": [] }, { "id": "1321", "type": "CID", "arg1_id": "1294", "arg2_id": "1285", "normalized": [] }, { "id": "1322", "type": "CID", "arg1_id": "1297", "arg2_id": "1285", "normalized": [] }, { "id": "1323", "type": "CID", "arg1_id": "1298", "arg2_id": "1285", "normalized": [] }, { "id": "1324", "type": "CID", "arg1_id": "1301", "arg2_id": "1285", "normalized": [] } ]

[ { "id": "1326", "type": "title", "text": [ "Diseases of peripheral nerves as seen in the Nigerian African." ], "offsets": [ [ 0, 62 ] ] }, { "id": "1327", "type": "abstract", "text": [ "The anatomical and aetiological diagnoses of peripheral nerve disease excluding its primary benign and malignant disorders, as seen in 358 Nigerians are presented. There is a male preponderance and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr syndrome was the commonest identifiable cause (15.6%), accounting for half of the cases with motor neuropathy. Peripheral neuropathy due to nutritional deficiency of thiamine and riboflavin was common (10.1%) and presented mainly as sensory and sensori-motor neuropathy. Diabetes mellitus was the major cause of autonomic neuropathy. Isoniazid was the most frequent agent in drug-induced neuropathy. Migraine (20%) was not an uncommon cause of cranial neuropathy although malignancies arising from the reticuloendothelial system or related structures of the head and neck were more frequent (26%). In 26.5% of all the cases, the aetiology of the neuropathy was undetermined. Heredofamilial and connective tissue disorders were rare. Some of the factors related to the clinical presentation and pathogenesis of the neuropathies are briefly discussed." ], "offsets": [ [ 63, 1233 ] ] } ]

[ { "id": "1328", "type": "Disease", "text": [ "Diseases of peripheral nerves" ], "offsets": [ [ 0, 29 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010523" } ] }, { "id": "1329", "type": "Disease", "text": [ "peripheral nerve disease" ], "offsets": [ [ 108, 132 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010523" } ] }, { "id": "1330", "type": "Disease", "text": [ "Sensori-motor neuropathy" ], "offsets": [ [ 305, 329 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010523" } ] }, { "id": "1331", "type": "Disease", "text": [ "Guillain-Barr syndrome" ], "offsets": [ [ 368, 392 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020275" } ] }, { "id": "1332", "type": "Disease", "text": [ "motor neuropathy" ], "offsets": [ [ 477, 493 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010523" } ] }, { "id": "1333", "type": "Disease", "text": [ "Peripheral neuropathy" ], "offsets": [ [ 495, 516 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010523" } ] }, { "id": "1334", "type": "Disease", "text": [ "nutritional deficiency" ], "offsets": [ [ 524, 546 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D044342" } ] }, { "id": "1335", "type": "Chemical", "text": [ "thiamine" ], "offsets": [ [ 550, 558 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013831" } ] }, { "id": "1336", "type": "Chemical", "text": [ "riboflavin" ], "offsets": [ [ 563, 573 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012256" } ] }, { "id": "1337", "type": "Disease", "text": [ "sensori-motor neuropathy" ], "offsets": [ [ 629, 653 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010523" } ] }, { "id": "1338", "type": "Disease", "text": [ "Diabetes mellitus" ], "offsets": [ [ 655, 672 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003920" } ] }, { "id": "1339", "type": "Disease", "text": [ "autonomic neuropathy" ], "offsets": [ [ 696, 716 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] }, { "id": "1340", "type": "Chemical", "text": [ "Isoniazid" ], "offsets": [ [ 718, 727 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007538" } ] }, { "id": "1341", "type": "Disease", "text": [ "neuropathy" ], "offsets": [ [ 772, 782 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] }, { "id": "1342", "type": "Disease", "text": [ "Migraine" ], "offsets": [ [ 784, 792 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "1343", "type": "Disease", "text": [ "cranial neuropathy" ], "offsets": [ [ 828, 846 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003389" } ] }, { "id": "1344", "type": "Disease", "text": [ "malignancies" ], "offsets": [ [ 856, 868 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "1345", "type": "Disease", "text": [ "neuropathy" ], "offsets": [ [ 1030, 1040 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] }, { "id": "1346", "type": "Disease", "text": [ "connective tissue disorders" ], "offsets": [ [ 1078, 1105 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003240" } ] }, { "id": "1347", "type": "Disease", "text": [ "neuropathies" ], "offsets": [ [ 1198, 1210 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] } ]

[]

[]

[ { "id": "1348", "type": "CID", "arg1_id": "1336", "arg2_id": "1328", "normalized": [] }, { "id": "1349", "type": "CID", "arg1_id": "1336", "arg2_id": "1329", "normalized": [] }, { "id": "1350", "type": "CID", "arg1_id": "1336", "arg2_id": "1330", "normalized": [] }, { "id": "1351", "type": "CID", "arg1_id": "1336", "arg2_id": "1332", "normalized": [] }, { "id": "1352", "type": "CID", "arg1_id": "1336", "arg2_id": "1333", "normalized": [] }, { "id": "1353", "type": "CID", "arg1_id": "1336", "arg2_id": "1337", "normalized": [] }, { "id": "1354", "type": "CID", "arg1_id": "1335", "arg2_id": "1328", "normalized": [] }, { "id": "1355", "type": "CID", "arg1_id": "1335", "arg2_id": "1329", "normalized": [] }, { "id": "1356", "type": "CID", "arg1_id": "1335", "arg2_id": "1330", "normalized": [] }, { "id": "1357", "type": "CID", "arg1_id": "1335", "arg2_id": "1332", "normalized": [] }, { "id": "1358", "type": "CID", "arg1_id": "1335", "arg2_id": "1333", "normalized": [] }, { "id": "1359", "type": "CID", "arg1_id": "1335", "arg2_id": "1337", "normalized": [] }, { "id": "1360", "type": "CID", "arg1_id": "1340", "arg2_id": "1328", "normalized": [] }, { "id": "1361", "type": "CID", "arg1_id": "1340", "arg2_id": "1329", "normalized": [] }, { "id": "1362", "type": "CID", "arg1_id": "1340", "arg2_id": "1330", "normalized": [] }, { "id": "1363", "type": "CID", "arg1_id": "1340", "arg2_id": "1332", "normalized": [] }, { "id": "1364", "type": "CID", "arg1_id": "1340", "arg2_id": "1333", "normalized": [] }, { "id": "1365", "type": "CID", "arg1_id": "1340", "arg2_id": "1337", "normalized": [] } ]

[ { "id": "1367", "type": "title", "text": [ "A double-blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder." ], "offsets": [ [ 0, 121 ] ] }, { "id": "1368", "type": "abstract", "text": [ "In a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective in alleviating the symptoms of depressive illness, and both were significantly superior to placebo. The overall incidence of side effects and the frequency and severity of blurred vision, dry mouth, and drowsiness were significantly less with dothiepin than with amitriptyline. Dothiepin also produced fewer CNS and cardiovascular effects. There were no clinically important changes in laboratory parameters. Dothiepin thus was found to be an effective antidepressant drug associated with fewer side effects than amitriptyline in the treatment of depressed outpatients." ], "offsets": [ [ 122, 892 ] ] } ]

[ { "id": "1369", "type": "Chemical", "text": [ "dothiepin hydrochloride" ], "offsets": [ [ 51, 74 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004308" } ] }, { "id": "1370", "type": "Disease", "text": [ "depressive disorder" ], "offsets": [ [ 101, 120 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "1371", "type": "Chemical", "text": [ "dothiepin" ], "offsets": [ [ 173, 182 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004308" } ] }, { "id": "1372", "type": "Chemical", "text": [ "amitriptyline" ], "offsets": [ [ 187, 200 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000639" } ] }, { "id": "1373", "type": "Disease", "text": [ "depressed" ], "offsets": [ [ 249, 258 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "1374", "type": "Chemical", "text": [ "Dothiepin" ], "offsets": [ [ 272, 281 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004308" } ] }, { "id": "1375", "type": "Chemical", "text": [ "amitriptyline" ], "offsets": [ [ 286, 299 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000639" } ] }, { "id": "1376", "type": "Disease", "text": [ "depressive illness" ], "offsets": [ [ 354, 372 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "1377", "type": "Disease", "text": [ "blurred vision" ], "offsets": [ [ 495, 509 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" } ] }, { "id": "1378", "type": "Disease", "text": [ "dry mouth" ], "offsets": [ [ 511, 520 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014987" } ] }, { "id": "1379", "type": "Chemical", "text": [ "dothiepin" ], "offsets": [ [ 566, 575 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004308" } ] }, { "id": "1380", "type": "Chemical", "text": [ "amitriptyline" ], "offsets": [ [ 586, 599 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000639" } ] }, { "id": "1381", "type": "Chemical", "text": [ "Dothiepin" ], "offsets": [ [ 601, 610 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004308" } ] }, { "id": "1382", "type": "Chemical", "text": [ "Dothiepin" ], "offsets": [ [ 732, 741 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004308" } ] }, { "id": "1383", "type": "Chemical", "text": [ "antidepressant" ], "offsets": [ [ 776, 790 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "1384", "type": "Chemical", "text": [ "amitriptyline" ], "offsets": [ [ 836, 849 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000639" } ] }, { "id": "1385", "type": "Disease", "text": [ "depressed" ], "offsets": [ [ 870, 879 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] } ]

[]

[]

[ { "id": "1386", "type": "CID", "arg1_id": "1372", "arg2_id": "1377", "normalized": [] }, { "id": "1387", "type": "CID", "arg1_id": "1375", "arg2_id": "1377", "normalized": [] }, { "id": "1388", "type": "CID", "arg1_id": "1380", "arg2_id": "1377", "normalized": [] }, { "id": "1389", "type": "CID", "arg1_id": "1384", "arg2_id": "1377", "normalized": [] }, { "id": "1390", "type": "CID", "arg1_id": "1372", "arg2_id": "1378", "normalized": [] }, { "id": "1391", "type": "CID", "arg1_id": "1375", "arg2_id": "1378", "normalized": [] }, { "id": "1392", "type": "CID", "arg1_id": "1380", "arg2_id": "1378", "normalized": [] }, { "id": "1393", "type": "CID", "arg1_id": "1384", "arg2_id": "1378", "normalized": [] } ]

[ { "id": "1395", "type": "title", "text": [ "Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia." ], "offsets": [ [ 0, 95 ] ] }, { "id": "1396", "type": "abstract", "text": [ "The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 weeks) on psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized and crossover design. Both drugs impaired immediate free recall but the decrease was greater for diazepam than propranolol. Delayed free recall was also impaired but the two drugs did not differ. Patients tapped faster after propranolol than diazepam and they were more sedated after diazepam than propranolol. After 2 weeks of treatment, patients tested 5-8 h after the last dose of medication did not show any decrement of performance. These results are similar to those previously found in healthy subjects. Accumulation of drugs was not reflected in prolonged behavioral impairment." ], "offsets": [ [ 96, 995 ] ] } ]

[ { "id": "1397", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 22, 30 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003975" } ] }, { "id": "1398", "type": "Chemical", "text": [ "propranolol" ], "offsets": [ [ 35, 46 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011433" } ] }, { "id": "1399", "type": "Disease", "text": [ "panic disorder" ], "offsets": [ [ 64, 78 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016584" } ] }, { "id": "1400", "type": "Disease", "text": [ "agoraphobia" ], "offsets": [ [ 83, 94 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000379" } ] }, { "id": "1401", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 125, 133 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003975" } ] }, { "id": "1402", "type": "Chemical", "text": [ "propranolol" ], "offsets": [ [ 204, 215 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011433" } ] }, { "id": "1403", "type": "Disease", "text": [ "panic disorders" ], "offsets": [ [ 329, 344 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016584" } ] }, { "id": "1404", "type": "Disease", "text": [ "agoraphobia" ], "offsets": [ [ 349, 360 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000379" } ] }, { "id": "1405", "type": "Disease", "text": [ "impaired immediate free recall" ], "offsets": [ [ 442, 472 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "1406", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 506, 514 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003975" } ] }, { "id": "1407", "type": "Chemical", "text": [ "propranolol" ], "offsets": [ [ 520, 531 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011433" } ] }, { "id": "1408", "type": "Disease", "text": [ "Delayed free recall was also impaired" ], "offsets": [ [ 533, 570 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "1409", "type": "Chemical", "text": [ "propranolol" ], "offsets": [ [ 634, 645 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011433" } ] }, { "id": "1410", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 651, 659 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003975" } ] }, { "id": "1411", "type": "Chemical", "text": [ "diazepam" ], "offsets": [ [ 693, 701 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003975" } ] }, { "id": "1412", "type": "Chemical", "text": [ "propranolol" ], "offsets": [ [ 707, 718 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011433" } ] }, { "id": "1413", "type": "Disease", "text": [ "behavioral impairment" ], "offsets": [ [ 973, 994 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001523" } ] } ]

[]

[]

[ { "id": "1414", "type": "CID", "arg1_id": "1398", "arg2_id": "1405", "normalized": [] }, { "id": "1415", "type": "CID", "arg1_id": "1398", "arg2_id": "1408", "normalized": [] }, { "id": "1416", "type": "CID", "arg1_id": "1402", "arg2_id": "1405", "normalized": [] }, { "id": "1417", "type": "CID", "arg1_id": "1402", "arg2_id": "1408", "normalized": [] }, { "id": "1418", "type": "CID", "arg1_id": "1407", "arg2_id": "1405", "normalized": [] }, { "id": "1419", "type": "CID", "arg1_id": "1407", "arg2_id": "1408", "normalized": [] }, { "id": "1420", "type": "CID", "arg1_id": "1409", "arg2_id": "1405", "normalized": [] }, { "id": "1421", "type": "CID", "arg1_id": "1409", "arg2_id": "1408", "normalized": [] }, { "id": "1422", "type": "CID", "arg1_id": "1412", "arg2_id": "1405", "normalized": [] }, { "id": "1423", "type": "CID", "arg1_id": "1412", "arg2_id": "1408", "normalized": [] }, { "id": "1424", "type": "CID", "arg1_id": "1397", "arg2_id": "1405", "normalized": [] }, { "id": "1425", "type": "CID", "arg1_id": "1397", "arg2_id": "1408", "normalized": [] }, { "id": "1426", "type": "CID", "arg1_id": "1401", "arg2_id": "1405", "normalized": [] }, { "id": "1427", "type": "CID", "arg1_id": "1401", "arg2_id": "1408", "normalized": [] }, { "id": "1428", "type": "CID", "arg1_id": "1406", "arg2_id": "1405", "normalized": [] }, { "id": "1429", "type": "CID", "arg1_id": "1406", "arg2_id": "1408", "normalized": [] }, { "id": "1430", "type": "CID", "arg1_id": "1410", "arg2_id": "1405", "normalized": [] }, { "id": "1431", "type": "CID", "arg1_id": "1410", "arg2_id": "1408", "normalized": [] }, { "id": "1432", "type": "CID", "arg1_id": "1411", "arg2_id": "1405", "normalized": [] }, { "id": "1433", "type": "CID", "arg1_id": "1411", "arg2_id": "1408", "normalized": [] } ]

[ { "id": "1435", "type": "title", "text": [ "Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat." ], "offsets": [ [ 0, 150 ] ] }, { "id": "1436", "type": "abstract", "text": [ "The co-administration of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induced bladder carcinomas but a concomitant induction of forestomach tumors. An autoradiographic study was performed on male F-344 rats fed diet containing FANFT at a level of 0.2% and/or aspirin at a level of 0.5% to evaluate the effect of aspirin on the increased cell proliferation induced by FANFT in the forestomach and bladder. FANFT-induced cell proliferation in the bladder was significantly suppressed by aspirin co-administration after 4 weeks but not after 12 weeks. In the forestomach, and also in the liver, aspirin did not affect the FANFT-induced increase in labeling index. The present results are consistent with the carcinogenicity experiment suggesting that different mechanisms are involved in FANFT carcinogenesis in the bladder and forestomach, and that aspirin's effect on FANFT in the forestomach is not due to an irritant effect associated with increased cell proliferation. Also, there appears to be an adaptation by the rats to the chronic ingestion of aspirin." ], "offsets": [ [ 151, 1281 ] ] } ]

[ { "id": "1437", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 10, 17 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "1438", "type": "Chemical", "text": [ "N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide" ], "offsets": [ [ 21, 66 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1439", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 176, 183 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "1440", "type": "Chemical", "text": [ "N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide" ], "offsets": [ [ 189, 234 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1441", "type": "Chemical", "text": [ "FANFT" ], "offsets": [ [ 236, 241 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1442", "type": "Chemical", "text": [ "FANFT" ], "offsets": [ [ 286, 291 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1443", "type": "Disease", "text": [ "bladder carcinomas" ], "offsets": [ [ 300, 318 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001749" } ] }, { "id": "1444", "type": "Disease", "text": [ "forestomach tumors" ], "offsets": [ [ 350, 368 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013274" } ] }, { "id": "1445", "type": "Chemical", "text": [ "FANFT" ], "offsets": [ [ 449, 454 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1446", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 481, 488 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "1447", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 534, 541 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "1448", "type": "Chemical", "text": [ "FANFT" ], "offsets": [ [ 589, 594 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1449", "type": "Chemical", "text": [ "FANFT" ], "offsets": [ [ 627, 632 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1450", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 707, 714 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "1451", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 814, 821 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "1452", "type": "Chemical", "text": [ "FANFT" ], "offsets": [ [ 841, 846 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1453", "type": "Chemical", "text": [ "FANFT" ], "offsets": [ [ 1007, 1012 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1454", "type": "Disease", "text": [ "carcinogenesis" ], "offsets": [ [ 1013, 1027 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D063646" } ] }, { "id": "1455", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 1069, 1076 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "1456", "type": "Chemical", "text": [ "FANFT" ], "offsets": [ [ 1089, 1094 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005200" } ] }, { "id": "1457", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 1273, 1280 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] } ]

[]

[]

[ { "id": "1458", "type": "CID", "arg1_id": "1438", "arg2_id": "1443", "normalized": [] }, { "id": "1459", "type": "CID", "arg1_id": "1440", "arg2_id": "1443", "normalized": [] }, { "id": "1460", "type": "CID", "arg1_id": "1441", "arg2_id": "1443", "normalized": [] }, { "id": "1461", "type": "CID", "arg1_id": "1442", "arg2_id": "1443", "normalized": [] }, { "id": "1462", "type": "CID", "arg1_id": "1445", "arg2_id": "1443", "normalized": [] }, { "id": "1463", "type": "CID", "arg1_id": "1448", "arg2_id": "1443", "normalized": [] }, { "id": "1464", "type": "CID", "arg1_id": "1449", "arg2_id": "1443", "normalized": [] }, { "id": "1465", "type": "CID", "arg1_id": "1452", "arg2_id": "1443", "normalized": [] }, { "id": "1466", "type": "CID", "arg1_id": "1453", "arg2_id": "1443", "normalized": [] }, { "id": "1467", "type": "CID", "arg1_id": "1456", "arg2_id": "1443", "normalized": [] }, { "id": "1468", "type": "CID", "arg1_id": "1438", "arg2_id": "1444", "normalized": [] }, { "id": "1469", "type": "CID", "arg1_id": "1440", "arg2_id": "1444", "normalized": [] }, { "id": "1470", "type": "CID", "arg1_id": "1441", "arg2_id": "1444", "normalized": [] }, { "id": "1471", "type": "CID", "arg1_id": "1442", "arg2_id": "1444", "normalized": [] }, { "id": "1472", "type": "CID", "arg1_id": "1445", "arg2_id": "1444", "normalized": [] }, { "id": "1473", "type": "CID", "arg1_id": "1448", "arg2_id": "1444", "normalized": [] }, { "id": "1474", "type": "CID", "arg1_id": "1449", "arg2_id": "1444", "normalized": [] }, { "id": "1475", "type": "CID", "arg1_id": "1452", "arg2_id": "1444", "normalized": [] }, { "id": "1476", "type": "CID", "arg1_id": "1453", "arg2_id": "1444", "normalized": [] }, { "id": "1477", "type": "CID", "arg1_id": "1456", "arg2_id": "1444", "normalized": [] } ]

[ { "id": "1479", "type": "title", "text": [ "Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy?" ], "offsets": [ [ 0, 86 ] ] }, { "id": "1480", "type": "abstract", "text": [ "The effect of nitroglycerin on heart rate and systolic blood pressure was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects with autonomic neuropathy. The magnitude and time course of the increase in heart rate and the decrease in systolic blood pressure after nitroglycerin were similar in the normal and diabetic subjects without autonomic neuropathy, whereas a lesser increase in heart rate and a greater decrease in systolic blood pressure occurred in the diabetic subjects with autonomic neuropathy. It is therefore suggested that caution should be exercised when prescribing vasodilator drugs in diabetic patients, particularly those with autonomic neuropathy." ], "offsets": [ [ 87, 809 ] ] } ]

[ { "id": "1481", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 24, 35 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "1482", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 39, 52 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "1483", "type": "Disease", "text": [ "diabetic autonomic neuropathy" ], "offsets": [ [ 56, 85 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003929" } ] }, { "id": "1484", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 101, 114 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "1485", "type": "Disease", "text": [ "diabetic" ], "offsets": [ [ 195, 203 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003920" } ] }, { "id": "1486", "type": "Disease", "text": [ "autonomic neuropathy" ], "offsets": [ [ 221, 241 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] }, { "id": "1487", "type": "Disease", "text": [ "diabetic" ], "offsets": [ [ 249, 257 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003920" } ] }, { "id": "1488", "type": "Disease", "text": [ "autonomic neuropathy" ], "offsets": [ [ 272, 292 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] }, { "id": "1489", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 404, 417 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "1490", "type": "Disease", "text": [ "diabetic" ], "offsets": [ [ 449, 457 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003920" } ] }, { "id": "1491", "type": "Disease", "text": [ "autonomic neuropathy" ], "offsets": [ [ 475, 495 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] }, { "id": "1492", "type": "Disease", "text": [ "diabetic" ], "offsets": [ [ 603, 611 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003920" } ] }, { "id": "1493", "type": "Disease", "text": [ "autonomic neuropathy" ], "offsets": [ [ 626, 646 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] }, { "id": "1494", "type": "Disease", "text": [ "diabetic" ], "offsets": [ [ 745, 753 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003920" } ] }, { "id": "1495", "type": "Disease", "text": [ "autonomic neuropathy" ], "offsets": [ [ 788, 808 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009422" } ] } ]

[]

[]

[ { "id": "1496", "type": "CID", "arg1_id": "1482", "arg2_id": "1481", "normalized": [] }, { "id": "1497", "type": "CID", "arg1_id": "1484", "arg2_id": "1481", "normalized": [] }, { "id": "1498", "type": "CID", "arg1_id": "1489", "arg2_id": "1481", "normalized": [] } ]

[ { "id": "1500", "type": "title", "text": [ "Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat." ], "offsets": [ [ 0, 84 ] ] }, { "id": "1501", "type": "abstract", "text": [ "Pituitary tumors were induced in F344 female rats by chronic treatment with diethylstilbestrol (DES, 8-10 mg) implanted subcutaneously in silastic capsules. Over a range of 1-150 days of DES treatment, pairs of control and DES-treated rats were sacrificed, and their pituitaries dissociated enzymatically into single-cell preparations. The cell populations were examined regarding total cell recovery correlated with gland weight, intracellular prolactin (PRL) content and subsequent release in primary culture, immunocytochemical PRL staining, density and/or size alterations via separation on Ficoll-Hypaque and by unit gravity sedimentation, and cell cycle analysis, after acriflavine DNA staining, by laser flow cytometry. Total cell yields from DES-treated pituitaries increased from 1.3 times control yields at 8 days of treatment to 58.9 times control values by day 150. Intracellular PRL content ranged from 1.9 to 9.4 times control levels, and PRL release in vitro was significantly and consistently higher than controls, after at least 8 days of DES exposure. Beyond 8 days of DES exposure, the immunochemically PRL-positive proportion of cells increased to over 50% of the total population. Increased density and/or size and PRL content were indicated for the majority of the PRL cell population in both types of separation protocols. All these effects of DES were more pronounced among previously ovariectomized animals. The data extend the findings of other investigators, further establishing the DES-induced tumor as a model for study of PRL cellular control mechanisms." ], "offsets": [ [ 85, 1670 ] ] } ]

[ { "id": "1502", "type": "Chemical", "text": [ "estrogen" ], "offsets": [ [ 20, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004967" } ] }, { "id": "1503", "type": "Disease", "text": [ "adenohypophyseal tumors" ], "offsets": [ [ 37, 60 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010911" } ] }, { "id": "1504", "type": "Disease", "text": [ "Pituitary tumors" ], "offsets": [ [ 85, 101 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010911" } ] }, { "id": "1505", "type": "Chemical", "text": [ "diethylstilbestrol" ], "offsets": [ [ 161, 179 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1506", "type": "Chemical", "text": [ "DES" ], "offsets": [ [ 181, 184 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1507", "type": "Chemical", "text": [ "DES" ], "offsets": [ [ 272, 275 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1508", "type": "Chemical", "text": [ "DES" ], "offsets": [ [ 308, 311 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1509", "type": "Chemical", "text": [ "acriflavine" ], "offsets": [ [ 761, 772 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000167" } ] }, { "id": "1510", "type": "Chemical", "text": [ "DES" ], "offsets": [ [ 835, 838 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1511", "type": "Chemical", "text": [ "DES" ], "offsets": [ [ 1141, 1144 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1512", "type": "Chemical", "text": [ "DES" ], "offsets": [ [ 1172, 1175 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1513", "type": "Chemical", "text": [ "DES" ], "offsets": [ [ 1452, 1455 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1514", "type": "Chemical", "text": [ "DES" ], "offsets": [ [ 1596, 1599 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004054" } ] }, { "id": "1515", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 1608, 1613 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] } ]

[]

[]

[ { "id": "1516", "type": "CID", "arg1_id": "1505", "arg2_id": "1503", "normalized": [] }, { "id": "1517", "type": "CID", "arg1_id": "1505", "arg2_id": "1504", "normalized": [] }, { "id": "1518", "type": "CID", "arg1_id": "1506", "arg2_id": "1503", "normalized": [] }, { "id": "1519", "type": "CID", "arg1_id": "1506", "arg2_id": "1504", "normalized": [] }, { "id": "1520", "type": "CID", "arg1_id": "1507", "arg2_id": "1503", "normalized": [] }, { "id": "1521", "type": "CID", "arg1_id": "1507", "arg2_id": "1504", "normalized": [] }, { "id": "1522", "type": "CID", "arg1_id": "1508", "arg2_id": "1503", "normalized": [] }, { "id": "1523", "type": "CID", "arg1_id": "1508", "arg2_id": "1504", "normalized": [] }, { "id": "1524", "type": "CID", "arg1_id": "1510", "arg2_id": "1503", "normalized": [] }, { "id": "1525", "type": "CID", "arg1_id": "1510", "arg2_id": "1504", "normalized": [] }, { "id": "1526", "type": "CID", "arg1_id": "1511", "arg2_id": "1503", "normalized": [] }, { "id": "1527", "type": "CID", "arg1_id": "1511", "arg2_id": "1504", "normalized": [] }, { "id": "1528", "type": "CID", "arg1_id": "1512", "arg2_id": "1503", "normalized": [] }, { "id": "1529", "type": "CID", "arg1_id": "1512", "arg2_id": "1504", "normalized": [] }, { "id": "1530", "type": "CID", "arg1_id": "1513", "arg2_id": "1503", "normalized": [] }, { "id": "1531", "type": "CID", "arg1_id": "1513", "arg2_id": "1504", "normalized": [] }, { "id": "1532", "type": "CID", "arg1_id": "1514", "arg2_id": "1503", "normalized": [] }, { "id": "1533", "type": "CID", "arg1_id": "1514", "arg2_id": "1504", "normalized": [] } ]

[ { "id": "1535", "type": "title", "text": [ "Triamterene nephrolithiasis complicating dyazide therapy." ], "offsets": [ [ 0, 57 ] ] }, { "id": "1536", "type": "abstract", "text": [ "A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide-triamterene therapy for hypertension. The stone passed spontaneously and was found to contain a triamterene metabolite admixed with uric acid salts. Factors affecting triamterene nephrolithiasis are discussed and 2 previously reported cases are reviewed." ], "offsets": [ [ 58, 408 ] ] } ]

[ { "id": "1537", "type": "Chemical", "text": [ "Triamterene" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014223" } ] }, { "id": "1538", "type": "Disease", "text": [ "nephrolithiasis" ], "offsets": [ [ 12, 27 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D053040" } ] }, { "id": "1539", "type": "Chemical", "text": [ "dyazide" ], "offsets": [ [ 41, 48 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C020743" } ] }, { "id": "1540", "type": "Chemical", "text": [ "triamterene" ], "offsets": [ [ 68, 79 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014223" } ] }, { "id": "1541", "type": "Disease", "text": [ "nephrolithiasis" ], "offsets": [ [ 80, 95 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D053040" } ] }, { "id": "1542", "type": "Chemical", "text": [ "hydrochlorothiazide-triamterene" ], "offsets": [ [ 134, 165 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C020743" } ] }, { "id": "1543", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 178, 190 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "1544", "type": "Chemical", "text": [ "triamterene" ], "offsets": [ [ 250, 261 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014223" } ] }, { "id": "1545", "type": "Chemical", "text": [ "uric acid salts" ], "offsets": [ [ 286, 301 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014527" }, { "db_name": "MESH", "db_id": "D012492" } ] }, { "id": "1546", "type": "Chemical", "text": [ "triamterene" ], "offsets": [ [ 321, 332 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014223" } ] }, { "id": "1547", "type": "Disease", "text": [ "nephrolithiasis" ], "offsets": [ [ 333, 348 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D053040" } ] } ]

[]

[]

[ { "id": "1548", "type": "CID", "arg1_id": "1537", "arg2_id": "1538", "normalized": [] }, { "id": "1549", "type": "CID", "arg1_id": "1537", "arg2_id": "1541", "normalized": [] }, { "id": "1550", "type": "CID", "arg1_id": "1537", "arg2_id": "1547", "normalized": [] }, { "id": "1551", "type": "CID", "arg1_id": "1540", "arg2_id": "1538", "normalized": [] }, { "id": "1552", "type": "CID", "arg1_id": "1540", "arg2_id": "1541", "normalized": [] }, { "id": "1553", "type": "CID", "arg1_id": "1540", "arg2_id": "1547", "normalized": [] }, { "id": "1554", "type": "CID", "arg1_id": "1544", "arg2_id": "1538", "normalized": [] }, { "id": "1555", "type": "CID", "arg1_id": "1544", "arg2_id": "1541", "normalized": [] }, { "id": "1556", "type": "CID", "arg1_id": "1544", "arg2_id": "1547", "normalized": [] }, { "id": "1557", "type": "CID", "arg1_id": "1546", "arg2_id": "1538", "normalized": [] }, { "id": "1558", "type": "CID", "arg1_id": "1546", "arg2_id": "1541", "normalized": [] }, { "id": "1559", "type": "CID", "arg1_id": "1546", "arg2_id": "1547", "normalized": [] } ]

[ { "id": "1561", "type": "title", "text": [ "Metabolic involvement in adriamycin cardiotoxicity." ], "offsets": [ [ 0, 51 ] ] }, { "id": "1562", "type": "abstract", "text": [ "The cardiotoxic effects of adriamycin were studied in mammalian myocardial cells in culture as a model system. Adriamycin inhibited cell growth and the rhythmic contractions characteristic of myocardial cells in culture. A possible involvement of energy metabolism was suggested previously, and in this study the adenylate energy charge and phosphorylcreatine mole fraction were determined in the adriamycin-treated cells. The adenylate energy charge was found to be significantly decreased, while the phophorylcreatine mole fraction was unchanged. Such disparity suggests an inhibition of creatine phosphokinase. The addition of 1 mM adenosine to the myocardial cell cultures markedly increases the ATP concentration through a pathway reportedly leading to a compartmentalized ATP pool. In the adriamycin-treated cells, the addition of adenosine increased the adenylate charge and, concomitant with this inrcease, the cells' functional integrity, in terms of percentage of beating cells and rate of contractions, was maintained." ], "offsets": [ [ 52, 1081 ] ] } ]

[ { "id": "1563", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 25, 35 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "1564", "type": "Disease", "text": [ "cardiotoxicity" ], "offsets": [ [ 36, 50 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D066126" } ] }, { "id": "1565", "type": "Disease", "text": [ "cardiotoxic" ], "offsets": [ [ 56, 67 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D066126" } ] }, { "id": "1566", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 79, 89 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "1567", "type": "Chemical", "text": [ "Adriamycin" ], "offsets": [ [ 163, 173 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "1568", "type": "Chemical", "text": [ "phosphorylcreatine" ], "offsets": [ [ 393, 411 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010725" } ] }, { "id": "1569", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 449, 459 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "1570", "type": "Chemical", "text": [ "phophorylcreatine" ], "offsets": [ [ 554, 571 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010725" } ] }, { "id": "1571", "type": "Chemical", "text": [ "creatine" ], "offsets": [ [ 642, 650 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003401" } ] }, { "id": "1572", "type": "Chemical", "text": [ "adenosine" ], "offsets": [ [ 687, 696 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000241" } ] }, { "id": "1573", "type": "Chemical", "text": [ "ATP" ], "offsets": [ [ 752, 755 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000255" } ] }, { "id": "1574", "type": "Chemical", "text": [ "ATP" ], "offsets": [ [ 830, 833 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000255" } ] }, { "id": "1575", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 847, 857 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "1576", "type": "Chemical", "text": [ "adenosine" ], "offsets": [ [ 889, 898 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000241" } ] } ]

[]

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[ { "id": "1577", "type": "CID", "arg1_id": "1563", "arg2_id": "1564", "normalized": [] }, { "id": "1578", "type": "CID", "arg1_id": "1563", "arg2_id": "1565", "normalized": [] }, { "id": "1579", "type": "CID", "arg1_id": "1566", "arg2_id": "1564", "normalized": [] }, { "id": "1580", "type": "CID", "arg1_id": "1566", "arg2_id": "1565", "normalized": [] }, { "id": "1581", "type": "CID", "arg1_id": "1567", "arg2_id": "1564", "normalized": [] }, { "id": "1582", "type": "CID", "arg1_id": "1567", "arg2_id": "1565", "normalized": [] }, { "id": "1583", "type": "CID", "arg1_id": "1569", "arg2_id": "1564", "normalized": [] }, { "id": "1584", "type": "CID", "arg1_id": "1569", "arg2_id": "1565", "normalized": [] }, { "id": "1585", "type": "CID", "arg1_id": "1575", "arg2_id": "1564", "normalized": [] }, { "id": "1586", "type": "CID", "arg1_id": "1575", "arg2_id": "1565", "normalized": [] } ]

[ { "id": "1588", "type": "title", "text": [ "Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin." ], "offsets": [ [ 0, 75 ] ] }, { "id": "1589", "type": "abstract", "text": [ "Streptomycin sulfate (300 mg/kg s.c.) was injected for various periods into preweanling rats and for 3 weeks into weanling rats. Beginning at 8 days of age, body movement and hearing were examined for 6 and up to 17 weeks, respectively. Abnormal movements and deafness occurred only in rats treated during the preweaning period; within this period the greatest sensitivities for these abnormalities occurred from 2 to 11-17 and 5 to 11 days of age, respectively, indicating that the cochlea is more sensitive to streptomycin than the site (vestibular or central) responsible for the dyskinesias." ], "offsets": [ [ 76, 671 ] ] } ]

[ { "id": "1590", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 40, 50 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020258" } ] }, { "id": "1591", "type": "Chemical", "text": [ "streptomycin" ], "offsets": [ [ 62, 74 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013307" } ] }, { "id": "1592", "type": "Chemical", "text": [ "Streptomycin" ], "offsets": [ [ 76, 88 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013307" } ] }, { "id": "1593", "type": "Disease", "text": [ "Abnormal movements" ], "offsets": [ [ 313, 331 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004409" } ] }, { "id": "1594", "type": "Disease", "text": [ "deafness" ], "offsets": [ [ 336, 344 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003638" } ] }, { "id": "1595", "type": "Chemical", "text": [ "streptomycin" ], "offsets": [ [ 588, 600 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013307" } ] }, { "id": "1596", "type": "Disease", "text": [ "dyskinesias" ], "offsets": [ [ 659, 670 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004409" } ] } ]

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[ { "id": "1597", "type": "CID", "arg1_id": "1591", "arg2_id": "1593", "normalized": [] }, { "id": "1598", "type": "CID", "arg1_id": "1591", "arg2_id": "1596", "normalized": [] }, { "id": "1599", "type": "CID", "arg1_id": "1592", "arg2_id": "1593", "normalized": [] }, { "id": "1600", "type": "CID", "arg1_id": "1592", "arg2_id": "1596", "normalized": [] }, { "id": "1601", "type": "CID", "arg1_id": "1595", "arg2_id": "1593", "normalized": [] }, { "id": "1602", "type": "CID", "arg1_id": "1595", "arg2_id": "1596", "normalized": [] }, { "id": "1603", "type": "CID", "arg1_id": "1591", "arg2_id": "1594", "normalized": [] }, { "id": "1604", "type": "CID", "arg1_id": "1592", "arg2_id": "1594", "normalized": [] }, { "id": "1605", "type": "CID", "arg1_id": "1595", "arg2_id": "1594", "normalized": [] } ]

[ { "id": "1607", "type": "title", "text": [ "Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis." ], "offsets": [ [ 0, 114 ] ] }, { "id": "1608", "type": "abstract", "text": [ "This case study reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this disease. This patient underwent a 10-month regimen of rifampin and isoniazid for pulmonary tuberculosis and was discovered to have developed signs of severe renal failure five weeks after completion of therapy. Renal biopsy revealed severe glomerulonephritis with crescents, electron dense fibrillar deposits and moderate lymphocytic interstitial infiltrate. Other possible causes of rapidly progressive glomerulonephritis were investigated and ruled out. This report documents the unusual occurrence of rapidly progressive glomerulonephritis with crescents and fibrillar glomerulonephritis in a patient treated with rifampin." ], "offsets": [ [ 115, 931 ] ] } ]

[ { "id": "1609", "type": "Disease", "text": [ "glomerulonephritis" ], "offsets": [ [ 22, 40 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005921" } ] }, { "id": "1610", "type": "Chemical", "text": [ "rifampin" ], "offsets": [ [ 70, 78 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012293" } ] }, { "id": "1611", "type": "Disease", "text": [ "pulmonary tuberculosis" ], "offsets": [ [ 91, 113 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014397" } ] }, { "id": "1612", "type": "Disease", "text": [ "glomerulonephritis" ], "offsets": [ [ 194, 212 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005921" } ] }, { "id": "1613", "type": "Chemical", "text": [ "rifampin" ], "offsets": [ [ 239, 247 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012293" } ] }, { "id": "1614", "type": "Chemical", "text": [ "rifampin" ], "offsets": [ [ 359, 367 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012293" } ] }, { "id": "1615", "type": "Chemical", "text": [ "isoniazid" ], "offsets": [ [ 372, 381 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007538" } ] }, { "id": "1616", "type": "Disease", "text": [ "pulmonary tuberculosis" ], "offsets": [ [ 386, 408 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014397" } ] }, { "id": "1617", "type": "Disease", "text": [ "renal failure" ], "offsets": [ [ 462, 475 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051437" } ] }, { "id": "1618", "type": "Disease", "text": [ "glomerulonephritis" ], "offsets": [ [ 545, 563 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005921" } ] }, { "id": "1619", "type": "Disease", "text": [ "glomerulonephritis" ], "offsets": [ [ 709, 727 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005921" } ] }, { "id": "1620", "type": "Disease", "text": [ "glomerulonephritis" ], "offsets": [ [ 829, 847 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005921" } ] }, { "id": "1621", "type": "Disease", "text": [ "glomerulonephritis" ], "offsets": [ [ 877, 895 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005921" } ] }, { "id": "1622", "type": "Chemical", "text": [ "rifampin" ], "offsets": [ [ 922, 930 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012293" } ] } ]

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[ { "id": "1623", "type": "CID", "arg1_id": "1610", "arg2_id": "1609", "normalized": [] }, { "id": "1624", "type": "CID", "arg1_id": "1610", "arg2_id": "1612", "normalized": [] }, { "id": "1625", "type": "CID", "arg1_id": "1610", "arg2_id": "1618", "normalized": [] }, { "id": "1626", "type": "CID", "arg1_id": "1610", "arg2_id": "1619", "normalized": [] }, { "id": "1627", "type": "CID", "arg1_id": "1610", "arg2_id": "1620", "normalized": [] }, { "id": "1628", "type": "CID", "arg1_id": "1610", "arg2_id": "1621", "normalized": [] }, { "id": "1629", "type": "CID", "arg1_id": "1613", "arg2_id": "1609", "normalized": [] }, { "id": "1630", "type": "CID", "arg1_id": "1613", "arg2_id": "1612", "normalized": [] }, { "id": "1631", "type": "CID", "arg1_id": "1613", "arg2_id": "1618", "normalized": [] }, { "id": "1632", "type": "CID", "arg1_id": "1613", "arg2_id": "1619", "normalized": [] }, { "id": "1633", "type": "CID", "arg1_id": "1613", "arg2_id": "1620", "normalized": [] }, { "id": "1634", "type": "CID", "arg1_id": "1613", "arg2_id": "1621", "normalized": [] }, { "id": "1635", "type": "CID", "arg1_id": "1614", "arg2_id": "1609", "normalized": [] }, { "id": "1636", "type": "CID", "arg1_id": "1614", "arg2_id": "1612", "normalized": [] }, { "id": "1637", "type": "CID", "arg1_id": "1614", "arg2_id": "1618", "normalized": [] }, { "id": "1638", "type": "CID", "arg1_id": "1614", "arg2_id": "1619", "normalized": [] }, { "id": "1639", "type": "CID", "arg1_id": "1614", "arg2_id": "1620", "normalized": [] }, { "id": "1640", "type": "CID", "arg1_id": "1614", "arg2_id": "1621", "normalized": [] }, { "id": "1641", "type": "CID", "arg1_id": "1622", "arg2_id": "1609", "normalized": [] }, { "id": "1642", "type": "CID", "arg1_id": "1622", "arg2_id": "1612", "normalized": [] }, { "id": "1643", "type": "CID", "arg1_id": "1622", "arg2_id": "1618", "normalized": [] }, { "id": "1644", "type": "CID", "arg1_id": "1622", "arg2_id": "1619", "normalized": [] }, { "id": "1645", "type": "CID", "arg1_id": "1622", "arg2_id": "1620", "normalized": [] }, { "id": "1646", "type": "CID", "arg1_id": "1622", "arg2_id": "1621", "normalized": [] }, { "id": "1647", "type": "CID", "arg1_id": "1610", "arg2_id": "1617", "normalized": [] }, { "id": "1648", "type": "CID", "arg1_id": "1613", "arg2_id": "1617", "normalized": [] }, { "id": "1649", "type": "CID", "arg1_id": "1614", "arg2_id": "1617", "normalized": [] }, { "id": "1650", "type": "CID", "arg1_id": "1622", "arg2_id": "1617", "normalized": [] } ]

[ { "id": "1652", "type": "title", "text": [ "Time course of lipid peroxidation in puromycin aminonucleoside-induced nephropathy." ], "offsets": [ [ 0, 83 ] ] }, { "id": "1653", "type": "abstract", "text": [ "Reactive oxygen species have been implicated in the pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly reducing the proteinuria. The temporal relationship between lipid peroxidation in the kidney and proteinuria was examined in this study. Rats were treated with a single IV injection of puromycin aminonucleoside, (PAN, 7.5 mg/kg) and 24 hour urine samples were obtained prior to sacrifice on days 3,5,7,10,17,27,41 (N = 5-10 per group). The kidneys were removed, flushed with ice cold TRIS buffer. Kidney cortices from each animal were used to prepare homogenates. Tissue lipid peroxidation was measured in whole homogenates as well as in lipid extracts from homogenates as thiobarbituric acid reactive substances. Proteinuria was evident at day 5, peaked at day 7 and persisted to day 27. Lipid peroxidation in homogenates was maximal at day 3 and declined rapidly to control levels by day 17. This study supports the role of lipid peroxidation in mediating the proteinuric injury in PAN nephropathy." ], "offsets": [ [ 84, 1143 ] ] } ]

[ { "id": "1654", "type": "Chemical", "text": [ "puromycin aminonucleoside" ], "offsets": [ [ 37, 62 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011692" } ] }, { "id": "1655", "type": "Disease", "text": [ "nephropathy" ], "offsets": [ [ 71, 82 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "1656", "type": "Chemical", "text": [ "oxygen" ], "offsets": [ [ 93, 99 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010100" } ] }, { "id": "1657", "type": "Chemical", "text": [ "puromycin aminonucleoside" ], "offsets": [ [ 158, 183 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011692" } ] }, { "id": "1658", "type": "Chemical", "text": [ "PAN" ], "offsets": [ [ 185, 188 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011692" } ] }, { "id": "1659", "type": "Disease", "text": [ "nephropathy" ], "offsets": [ [ 198, 209 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "1660", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 256, 267 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "1661", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 340, 351 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "1662", "type": "Chemical", "text": [ "puromycin aminonucleoside" ], "offsets": [ [ 428, 453 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011692" } ] }, { "id": "1663", "type": "Chemical", "text": [ "PAN" ], "offsets": [ [ 456, 459 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011692" } ] }, { "id": "1664", "type": "Chemical", "text": [ "thiobarbituric acid" ], "offsets": [ [ 816, 835 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C029684" } ] }, { "id": "1665", "type": "Disease", "text": [ "Proteinuria" ], "offsets": [ [ 857, 868 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "1666", "type": "Disease", "text": [ "proteinuric injury" ], "offsets": [ [ 1105, 1123 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "1667", "type": "Chemical", "text": [ "PAN" ], "offsets": [ [ 1127, 1130 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011692" } ] }, { "id": "1668", "type": "Disease", "text": [ "nephropathy" ], "offsets": [ [ 1131, 1142 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] } ]

[]

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[ { "id": "1669", "type": "CID", "arg1_id": "1654", "arg2_id": "1655", "normalized": [] }, { "id": "1670", "type": "CID", "arg1_id": "1654", "arg2_id": "1659", "normalized": [] }, { "id": "1671", "type": "CID", "arg1_id": "1654", "arg2_id": "1668", "normalized": [] }, { "id": "1672", "type": "CID", "arg1_id": "1657", "arg2_id": "1655", "normalized": [] }, { "id": "1673", "type": "CID", "arg1_id": "1657", "arg2_id": "1659", "normalized": [] }, { "id": "1674", "type": "CID", "arg1_id": "1657", "arg2_id": "1668", "normalized": [] }, { "id": "1675", "type": "CID", "arg1_id": "1658", "arg2_id": "1655", "normalized": [] }, { "id": "1676", "type": "CID", "arg1_id": "1658", "arg2_id": "1659", "normalized": [] }, { "id": "1677", "type": "CID", "arg1_id": "1658", "arg2_id": "1668", "normalized": [] }, { "id": "1678", "type": "CID", "arg1_id": "1662", "arg2_id": "1655", "normalized": [] }, { "id": "1679", "type": "CID", "arg1_id": "1662", "arg2_id": "1659", "normalized": [] }, { "id": "1680", "type": "CID", "arg1_id": "1662", "arg2_id": "1668", "normalized": [] }, { "id": "1681", "type": "CID", "arg1_id": "1663", "arg2_id": "1655", "normalized": [] }, { "id": "1682", "type": "CID", "arg1_id": "1663", "arg2_id": "1659", "normalized": [] }, { "id": "1683", "type": "CID", "arg1_id": "1663", "arg2_id": "1668", "normalized": [] }, { "id": "1684", "type": "CID", "arg1_id": "1667", "arg2_id": "1655", "normalized": [] }, { "id": "1685", "type": "CID", "arg1_id": "1667", "arg2_id": "1659", "normalized": [] }, { "id": "1686", "type": "CID", "arg1_id": "1667", "arg2_id": "1668", "normalized": [] }, { "id": "1687", "type": "CID", "arg1_id": "1654", "arg2_id": "1660", "normalized": [] }, { "id": "1688", "type": "CID", "arg1_id": "1654", "arg2_id": "1661", "normalized": [] }, { "id": "1689", "type": "CID", "arg1_id": "1654", "arg2_id": "1665", "normalized": [] }, { "id": "1690", "type": "CID", "arg1_id": "1654", "arg2_id": "1666", "normalized": [] }, { "id": "1691", "type": "CID", "arg1_id": "1657", "arg2_id": "1660", "normalized": [] }, { "id": "1692", "type": "CID", "arg1_id": "1657", "arg2_id": "1661", "normalized": [] }, { "id": "1693", "type": "CID", "arg1_id": "1657", "arg2_id": "1665", "normalized": [] }, { "id": "1694", "type": "CID", "arg1_id": "1657", "arg2_id": "1666", "normalized": [] }, { "id": "1695", "type": "CID", "arg1_id": "1658", "arg2_id": "1660", "normalized": [] }, { "id": "1696", "type": "CID", "arg1_id": "1658", "arg2_id": "1661", "normalized": [] }, { "id": "1697", "type": "CID", "arg1_id": "1658", "arg2_id": "1665", "normalized": [] }, { "id": "1698", "type": "CID", "arg1_id": "1658", "arg2_id": "1666", "normalized": [] }, { "id": "1699", "type": "CID", "arg1_id": "1662", "arg2_id": "1660", "normalized": [] }, { "id": "1700", "type": "CID", "arg1_id": "1662", "arg2_id": "1661", "normalized": [] }, { "id": "1701", "type": "CID", "arg1_id": "1662", "arg2_id": "1665", "normalized": [] }, { "id": "1702", "type": "CID", "arg1_id": "1662", "arg2_id": "1666", "normalized": [] }, { "id": "1703", "type": "CID", "arg1_id": "1663", "arg2_id": "1660", "normalized": [] }, { "id": "1704", "type": "CID", "arg1_id": "1663", "arg2_id": "1661", "normalized": [] }, { "id": "1705", "type": "CID", "arg1_id": "1663", "arg2_id": "1665", "normalized": [] }, { "id": "1706", "type": "CID", "arg1_id": "1663", "arg2_id": "1666", "normalized": [] }, { "id": "1707", "type": "CID", "arg1_id": "1667", "arg2_id": "1660", "normalized": [] }, { "id": "1708", "type": "CID", "arg1_id": "1667", "arg2_id": "1661", "normalized": [] }, { "id": "1709", "type": "CID", "arg1_id": "1667", "arg2_id": "1665", "normalized": [] }, { "id": "1710", "type": "CID", "arg1_id": "1667", "arg2_id": "1666", "normalized": [] } ]

[ { "id": "1712", "type": "title", "text": [ "Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action." ], "offsets": [ [ 0, 86 ] ] }, { "id": "1713", "type": "abstract", "text": [ "The present study was undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate of prolactin (PRL) in addition to the direct drug effect. Two groups of supine subjects were studied under placebo-controlled conditions, one during the night, when sleeping (n = 7) and the other at daytime, when awake (n = 6). Each subject received a single 50 mg dose of clomipramine given orally 2 hours before blood collection. Plasma PRL concentrations were analysed at 10 min intervals and underlying secretory rates calculated by a deconvolution procedure. For both experiments the drug intake led to significant increases in PRL secretion, acting preferentially on tonic secretion as pulse amplitude and frequency did not differ significantly from corresponding control values. During the night clomipramine ingestion altered the complete sleep architecture in that it suppressed REM sleep and the sleep cycles and induced increased wakefulness. As the relative increase in PRL secretion expressed as a percentage of the mean did not significantly differ between the night and day time studies (46 +/- 19% vs 34 +/- 10%), it can be concluded that the observed sleep disturbance did not interfere with the drug action per se. The presence of REM sleep was shown not to be a determining factor either for secretory pulse amplitude and frequency, as, for both, mean nocturnal values were similar with and without prior clomipramine ingestion." ], "offsets": [ [ 87, 1571 ] ] } ]

[ { "id": "1714", "type": "Chemical", "text": [ "Clomipramine" ], "offsets": [ [ 0, 12 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002997" } ] }, { "id": "1715", "type": "Disease", "text": [ "sleep disturbance" ], "offsets": [ [ 21, 38 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012893" } ] }, { "id": "1716", "type": "Disease", "text": [ "sleep disturbance" ], "offsets": [ [ 143, 160 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012893" } ] }, { "id": "1717", "type": "Chemical", "text": [ "clomipramine" ], "offsets": [ [ 173, 185 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002997" } ] }, { "id": "1718", "type": "Chemical", "text": [ "clomipramine" ], "offsets": [ [ 497, 509 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002997" } ] }, { "id": "1719", "type": "Chemical", "text": [ "clomipramine" ], "offsets": [ [ 927, 939 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002997" } ] }, { "id": "1720", "type": "Disease", "text": [ "sleep disturbance" ], "offsets": [ [ 1292, 1309 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012893" } ] }, { "id": "1721", "type": "Chemical", "text": [ "clomipramine" ], "offsets": [ [ 1548, 1560 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002997" } ] } ]

[]

[]

[ { "id": "1722", "type": "CID", "arg1_id": "1714", "arg2_id": "1715", "normalized": [] }, { "id": "1723", "type": "CID", "arg1_id": "1714", "arg2_id": "1716", "normalized": [] }, { "id": "1724", "type": "CID", "arg1_id": "1714", "arg2_id": "1720", "normalized": [] }, { "id": "1725", "type": "CID", "arg1_id": "1717", "arg2_id": "1715", "normalized": [] }, { "id": "1726", "type": "CID", "arg1_id": "1717", "arg2_id": "1716", "normalized": [] }, { "id": "1727", "type": "CID", "arg1_id": "1717", "arg2_id": "1720", "normalized": [] }, { "id": "1728", "type": "CID", "arg1_id": "1718", "arg2_id": "1715", "normalized": [] }, { "id": "1729", "type": "CID", "arg1_id": "1718", "arg2_id": "1716", "normalized": [] }, { "id": "1730", "type": "CID", "arg1_id": "1718", "arg2_id": "1720", "normalized": [] }, { "id": "1731", "type": "CID", "arg1_id": "1719", "arg2_id": "1715", "normalized": [] }, { "id": "1732", "type": "CID", "arg1_id": "1719", "arg2_id": "1716", "normalized": [] }, { "id": "1733", "type": "CID", "arg1_id": "1719", "arg2_id": "1720", "normalized": [] }, { "id": "1734", "type": "CID", "arg1_id": "1721", "arg2_id": "1715", "normalized": [] }, { "id": "1735", "type": "CID", "arg1_id": "1721", "arg2_id": "1716", "normalized": [] }, { "id": "1736", "type": "CID", "arg1_id": "1721", "arg2_id": "1720", "normalized": [] } ]

[ { "id": "1738", "type": "title", "text": [ "Angioedema following the intravenous administration of metoprolol." ], "offsets": [ [ 0, 66 ] ] }, { "id": "1739", "type": "abstract", "text": [ "A 72-year-old woman was admitted to the hospital with \"flash\" pulmonary edema, preceded by chest pain, requiring intubation. Her medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mellitus. A history of angioedema secondary to lisinopril therapy was elicited. Current medications did not include angiotensin-converting enzyme inhibitors or beta-blockers. She had no previous beta-blocking drug exposure. During the first day of hospitalization (while intubated), intravenous metoprolol was given, resulting in severe angioedema. The angioedema resolved after therapy with intravenous steroids and diphenhydramine hydrochloride." ], "offsets": [ [ 67, 757 ] ] } ]

[ { "id": "1740", "type": "Disease", "text": [ "Angioedema" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000799" } ] }, { "id": "1741", "type": "Chemical", "text": [ "metoprolol" ], "offsets": [ [ 55, 65 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008790" } ] }, { "id": "1742", "type": "Disease", "text": [ "pulmonary edema" ], "offsets": [ [ 129, 144 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011654" } ] }, { "id": "1743", "type": "Disease", "text": [ "chest pain" ], "offsets": [ [ 158, 168 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002637" } ] }, { "id": "1744", "type": "Disease", "text": [ "coronary artery disease" ], "offsets": [ [ 221, 244 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003324" } ] }, { "id": "1745", "type": "Disease", "text": [ "myocardial infarctions" ], "offsets": [ [ 259, 281 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "1746", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 283, 295 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "1747", "type": "Disease", "text": [ "diabetes mellitus" ], "offsets": [ [ 301, 318 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003920" } ] }, { "id": "1748", "type": "Disease", "text": [ "angioedema" ], "offsets": [ [ 333, 343 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000799" } ] }, { "id": "1749", "type": "Chemical", "text": [ "lisinopril" ], "offsets": [ [ 357, 367 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017706" } ] }, { "id": "1750", "type": "Chemical", "text": [ "angiotensin" ], "offsets": [ [ 426, 437 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000809" } ] }, { "id": "1751", "type": "Chemical", "text": [ "metoprolol" ], "offsets": [ [ 605, 615 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008790" } ] }, { "id": "1752", "type": "Disease", "text": [ "angioedema" ], "offsets": [ [ 647, 657 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000799" } ] }, { "id": "1753", "type": "Disease", "text": [ "angioedema" ], "offsets": [ [ 663, 673 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000799" } ] }, { "id": "1754", "type": "Chemical", "text": [ "steroids" ], "offsets": [ [ 714, 722 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013256" } ] }, { "id": "1755", "type": "Chemical", "text": [ "diphenhydramine" ], "offsets": [ [ 727, 742 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004155" } ] } ]

[]

[]

[ { "id": "1756", "type": "CID", "arg1_id": "1741", "arg2_id": "1740", "normalized": [] }, { "id": "1757", "type": "CID", "arg1_id": "1741", "arg2_id": "1748", "normalized": [] }, { "id": "1758", "type": "CID", "arg1_id": "1741", "arg2_id": "1752", "normalized": [] }, { "id": "1759", "type": "CID", "arg1_id": "1741", "arg2_id": "1753", "normalized": [] }, { "id": "1760", "type": "CID", "arg1_id": "1751", "arg2_id": "1740", "normalized": [] }, { "id": "1761", "type": "CID", "arg1_id": "1751", "arg2_id": "1748", "normalized": [] }, { "id": "1762", "type": "CID", "arg1_id": "1751", "arg2_id": "1752", "normalized": [] }, { "id": "1763", "type": "CID", "arg1_id": "1751", "arg2_id": "1753", "normalized": [] }, { "id": "1764", "type": "CID", "arg1_id": "1749", "arg2_id": "1740", "normalized": [] }, { "id": "1765", "type": "CID", "arg1_id": "1749", "arg2_id": "1748", "normalized": [] }, { "id": "1766", "type": "CID", "arg1_id": "1749", "arg2_id": "1752", "normalized": [] }, { "id": "1767", "type": "CID", "arg1_id": "1749", "arg2_id": "1753", "normalized": [] } ]

[ { "id": "1769", "type": "title", "text": [ "Effect of coniine on the developing chick embryo." ], "offsets": [ [ 0, 49 ] ] }, { "id": "1770", "type": "abstract", "text": [ "Coniine, an alkaloid from Conium maculatum (poison hemlock), has been shown to be teratogenic in livestock. The major teratogenic outcome is arthrogryposis, presumably due to nicotinic receptor blockade. However, coniine has failed to produce arthrogryposis in rats or mice and is only weakly teratogenic in rabbits. The purpose of this study was to evaluate and compare the effects of coniine and nicotine in the developing chick. Concentrations of coniine and nicotine sulfate were 0.015%, 0.03%, 0.075%, 0.15%, 0.75%, 1.5%, 3%, and 6% and 1%, 5%, and 10%, respectively. Both compounds caused deformations and lethality in a dose-dependent manner. All concentrations of nicotine sulfate caused some lethality but a no effect level for coniine lethality was 0.75%. The deformations caused by both coniine and nicotine sulfate were excessive flexion or extension of one or more toes. No histopathological alterations or differences in bone formation were seen in the limbs or toes of any chicks from any group; however, extensive cranial hemorrhage occurred in all nicotine sulfate-treated chicks. There was a statistically significant (P < or = 0.01) decrease in movement in coniine and nicotine sulfate treated chicks as determined by ultrasound. Control chicks were in motion an average of 33.67% of the time, while coniine-treated chicks were only moving 8.95% of a 5-min interval, and no movement was observed for nicotine sulfate treated chicks. In summary, the chick embryo provides a reliable and simple experimental animal model of coniine-induced arthrogryposis. Data from this model support a mechanism involving nicotinic receptor blockade with subsequent decreased fetal movement." ], "offsets": [ [ 50, 1743 ] ] } ]

[ { "id": "1771", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 10, 17 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1772", "type": "Chemical", "text": [ "Coniine" ], "offsets": [ [ 50, 57 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1773", "type": "Disease", "text": [ "arthrogryposis" ], "offsets": [ [ 191, 205 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001176" } ] }, { "id": "1774", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 263, 270 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1775", "type": "Disease", "text": [ "arthrogryposis" ], "offsets": [ [ 293, 307 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001176" } ] }, { "id": "1776", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 436, 443 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1777", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 448, 456 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "1778", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 500, 507 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1779", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 512, 520 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "1780", "type": "Disease", "text": [ "deformations" ], "offsets": [ [ 645, 657 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009140" } ] }, { "id": "1781", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 722, 730 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "1782", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 787, 794 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1783", "type": "Disease", "text": [ "deformations" ], "offsets": [ [ 820, 832 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009140" } ] }, { "id": "1784", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 848, 855 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1785", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 860, 868 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "1786", "type": "Disease", "text": [ "excessive flexion or extension of one or more toes" ], "offsets": [ [ 882, 932 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009140" } ] }, { "id": "1787", "type": "Disease", "text": [ "cranial hemorrhage" ], "offsets": [ [ 1080, 1098 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002543" } ] }, { "id": "1788", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 1115, 1123 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "1789", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 1226, 1233 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1790", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 1238, 1246 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "1791", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 1369, 1376 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1792", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 1469, 1477 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "1793", "type": "Chemical", "text": [ "coniine" ], "offsets": [ [ 1591, 1598 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C007112" } ] }, { "id": "1794", "type": "Disease", "text": [ "arthrogryposis" ], "offsets": [ [ 1607, 1621 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001176" } ] } ]

[]

[]

[ { "id": "1795", "type": "CID", "arg1_id": "1777", "arg2_id": "1773", "normalized": [] }, { "id": "1796", "type": "CID", "arg1_id": "1777", "arg2_id": "1775", "normalized": [] }, { "id": "1797", "type": "CID", "arg1_id": "1777", "arg2_id": "1794", "normalized": [] }, { "id": "1798", "type": "CID", "arg1_id": "1779", "arg2_id": "1773", "normalized": [] }, { "id": "1799", "type": "CID", "arg1_id": "1779", "arg2_id": "1775", "normalized": [] }, { "id": "1800", "type": "CID", "arg1_id": "1779", "arg2_id": "1794", "normalized": [] }, { "id": "1801", "type": "CID", "arg1_id": "1781", "arg2_id": "1773", "normalized": [] }, { "id": "1802", "type": "CID", "arg1_id": "1781", "arg2_id": "1775", "normalized": [] }, { "id": "1803", "type": "CID", "arg1_id": "1781", "arg2_id": "1794", "normalized": [] }, { "id": "1804", "type": "CID", "arg1_id": "1785", "arg2_id": "1773", "normalized": [] }, { "id": "1805", "type": "CID", "arg1_id": "1785", "arg2_id": "1775", "normalized": [] }, { "id": "1806", "type": "CID", "arg1_id": "1785", "arg2_id": "1794", "normalized": [] }, { "id": "1807", "type": "CID", "arg1_id": "1788", "arg2_id": "1773", "normalized": [] }, { "id": "1808", "type": "CID", "arg1_id": "1788", "arg2_id": "1775", "normalized": [] }, { "id": "1809", "type": "CID", "arg1_id": "1788", "arg2_id": "1794", "normalized": [] }, { "id": "1810", "type": "CID", "arg1_id": "1790", "arg2_id": "1773", "normalized": [] }, { "id": "1811", "type": "CID", "arg1_id": "1790", "arg2_id": "1775", "normalized": [] }, { "id": "1812", "type": "CID", "arg1_id": "1790", "arg2_id": "1794", "normalized": [] }, { "id": "1813", "type": "CID", "arg1_id": "1792", "arg2_id": "1773", "normalized": [] }, { "id": "1814", "type": "CID", "arg1_id": "1792", "arg2_id": "1775", "normalized": [] }, { "id": "1815", "type": "CID", "arg1_id": "1792", "arg2_id": "1794", "normalized": [] }, { "id": "1816", "type": "CID", "arg1_id": "1771", "arg2_id": "1773", "normalized": [] }, { "id": "1817", "type": "CID", 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"arg2_id": "1773", "normalized": [] }, { "id": "1829", "type": "CID", "arg1_id": "1778", "arg2_id": "1775", "normalized": [] }, { "id": "1830", "type": "CID", "arg1_id": "1778", "arg2_id": "1794", "normalized": [] }, { "id": "1831", "type": "CID", "arg1_id": "1782", "arg2_id": "1773", "normalized": [] }, { "id": "1832", "type": "CID", "arg1_id": "1782", "arg2_id": "1775", "normalized": [] }, { "id": "1833", "type": "CID", "arg1_id": "1782", "arg2_id": "1794", "normalized": [] }, { "id": "1834", "type": "CID", "arg1_id": "1784", "arg2_id": "1773", "normalized": [] }, { "id": "1835", "type": "CID", "arg1_id": "1784", "arg2_id": "1775", "normalized": [] }, { "id": "1836", "type": "CID", "arg1_id": "1784", "arg2_id": "1794", "normalized": [] }, { "id": "1837", "type": "CID", "arg1_id": "1789", "arg2_id": "1773", "normalized": [] }, { "id": "1838", "type": "CID", "arg1_id": "1789", "arg2_id": "1775", "normalized": [] }, { "id": "1839", "type": "CID", "arg1_id": "1789", "arg2_id": "1794", "normalized": [] }, { "id": "1840", "type": "CID", "arg1_id": "1791", "arg2_id": "1773", "normalized": [] }, { "id": "1841", "type": "CID", "arg1_id": "1791", "arg2_id": "1775", "normalized": [] }, { "id": "1842", "type": "CID", "arg1_id": "1791", "arg2_id": "1794", "normalized": [] }, { "id": "1843", "type": "CID", "arg1_id": "1793", "arg2_id": "1773", "normalized": [] }, { "id": "1844", "type": "CID", "arg1_id": "1793", "arg2_id": "1775", "normalized": [] }, { "id": "1845", "type": "CID", "arg1_id": "1793", "arg2_id": "1794", "normalized": [] }, { "id": "1846", "type": "CID", "arg1_id": "1777", "arg2_id": "1787", "normalized": [] }, { "id": "1847", "type": "CID", "arg1_id": "1779", "arg2_id": "1787", "normalized": [] }, { "id": "1848", "type": "CID", "arg1_id": "1781", "arg2_id": "1787", "normalized": [] }, { "id": "1849", "type": "CID", "arg1_id": "1785", "arg2_id": "1787", "normalized": [] }, { "id": "1850", "type": "CID", "arg1_id": "1788", "arg2_id": "1787", "normalized": [] }, { "id": "1851", "type": "CID", "arg1_id": "1790", "arg2_id": "1787", "normalized": [] }, { "id": "1852", "type": "CID", "arg1_id": "1792", "arg2_id": "1787", "normalized": [] } ]

[ { "id": "1854", "type": "title", "text": [ "Epidural blood flow during prostaglandin E1 or trimethaphan induced hypotension." ], "offsets": [ [ 0, 80 ] ] }, { "id": "1855", "type": "abstract", "text": [ "To evaluate the effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural blood flow (EBF) during spinal surgery, EBF was measured using the heat clearance method in 30 patients who underwent postero-lateral interbody fusion under isoflurane anaesthesia. An initial dose of 0.1 microgram.kg-1.min-1 of PGE1 (15 patients), or 10 micrograms.kg-1.min-1 of TMP (15 patients) was administered intravenously after the dural opening and the dose was adjusted to maintain the mean arterial blood pressure (MAP) at about 60 mmHg. The hypotensive drug was discontinued at the completion of the operative procedure. After starting PGE1 or TMP, MAP and rate pressure product (RPP) decreased significantly compared with preinfusion values (P < 0.01), and the degree of hypotension due to PGE1 remained constant until 60 min after its discontinuation. Heart rate (HR) did not change in either group. EBFF did not change during PGE1 infusion whereas in the TMP group, EBF decreased significantly at 30 and 60 min after the start of TMP (preinfusion: 45.9 +/- 13.9 ml/100g/min. 30 min: 32.3 +/- 9.9 ml/100 g/min (P < 0.05). 60 min: 30 +/- 7.5 ml/100 g/min (P < 0.05)). These results suggest that PGE1 may be preferable to TMP for hypotensive anaesthesia in spinal surgery because TMP decreased EBF." ], "offsets": [ [ 81, 1393 ] ] } ]

[ { "id": "1856", "type": "Chemical", "text": [ "prostaglandin E1" ], "offsets": [ [ 27, 43 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000527" } ] }, { "id": "1857", "type": "Chemical", "text": [ "trimethaphan" ], "offsets": [ [ 47, 59 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] }, { "id": "1858", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 68, 79 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "1859", "type": "Chemical", "text": [ "prostaglandin E1" ], "offsets": [ [ 107, 123 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000527" } ] }, { "id": "1860", "type": "Chemical", "text": [ "PGE1" ], "offsets": [ [ 125, 129 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000527" } ] }, { "id": "1861", "type": "Chemical", "text": [ "trimethaphan" ], "offsets": [ [ 134, 146 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] }, { "id": "1862", "type": "Chemical", "text": [ "TMP" ], "offsets": [ [ 148, 151 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] }, { "id": "1863", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 161, 172 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "1864", "type": "Chemical", "text": [ "isoflurane" ], "offsets": [ [ 342, 352 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007530" } ] }, { "id": "1865", "type": "Chemical", "text": [ "PGE1" ], "offsets": [ [ 413, 417 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000527" } ] }, { "id": "1866", "type": "Chemical", "text": [ "TMP" ], "offsets": [ [ 464, 467 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] }, { "id": "1867", "type": "Disease", "text": [ "hypotensive" ], "offsets": [ [ 636, 647 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "1868", "type": "Chemical", "text": [ "PGE1" ], "offsets": [ [ 731, 735 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000527" } ] }, { "id": "1869", "type": "Chemical", "text": [ "TMP" ], "offsets": [ [ 739, 742 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] }, { "id": "1870", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 867, 878 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "1871", "type": "Chemical", "text": [ "PGE1" ], "offsets": [ [ 886, 890 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000527" } ] }, { "id": "1872", "type": "Chemical", "text": [ "PGE1" ], "offsets": [ [ 1024, 1028 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000527" } ] }, { "id": "1873", "type": "Chemical", "text": [ "TMP" ], "offsets": [ [ 1053, 1056 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] }, { "id": "1874", "type": "Chemical", "text": [ "TMP" ], "offsets": [ [ 1128, 1131 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] }, { "id": "1875", "type": "Chemical", "text": [ "PGE1" ], "offsets": [ [ 1291, 1295 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000527" } ] }, { "id": "1876", "type": "Chemical", "text": [ "TMP" ], "offsets": [ [ 1317, 1320 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] }, { "id": "1877", "type": "Disease", "text": [ "hypotensive" ], "offsets": [ [ 1325, 1336 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "1878", "type": "Chemical", "text": [ "TMP" ], "offsets": [ [ 1375, 1378 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014294" } ] } ]

[]

[]

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"type": "CID", "arg1_id": "1862", "arg2_id": "1863", "normalized": [] }, { "id": "1891", "type": "CID", "arg1_id": "1862", "arg2_id": "1867", "normalized": [] }, { "id": "1892", "type": "CID", "arg1_id": "1862", "arg2_id": "1870", "normalized": [] }, { "id": "1893", "type": "CID", "arg1_id": "1862", "arg2_id": "1877", "normalized": [] }, { "id": "1894", "type": "CID", "arg1_id": "1866", "arg2_id": "1858", "normalized": [] }, { "id": "1895", "type": "CID", "arg1_id": "1866", "arg2_id": "1863", "normalized": [] }, { "id": "1896", "type": "CID", "arg1_id": "1866", "arg2_id": "1867", "normalized": [] }, { "id": "1897", "type": "CID", "arg1_id": "1866", "arg2_id": "1870", "normalized": [] }, { "id": "1898", "type": "CID", "arg1_id": "1866", "arg2_id": "1877", "normalized": [] }, { "id": "1899", "type": "CID", "arg1_id": "1869", "arg2_id": "1858", "normalized": [] }, { "id": "1900", "type": "CID", "arg1_id": "1869", "arg2_id": "1863", "normalized": [] }, { "id": "1901", "type": "CID", 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"id": "1935", "type": "CID", "arg1_id": "1860", "arg2_id": "1863", "normalized": [] }, { "id": "1936", "type": "CID", "arg1_id": "1860", "arg2_id": "1867", "normalized": [] }, { "id": "1937", "type": "CID", "arg1_id": "1860", "arg2_id": "1870", "normalized": [] }, { "id": "1938", "type": "CID", "arg1_id": "1860", "arg2_id": "1877", "normalized": [] }, { "id": "1939", "type": "CID", "arg1_id": "1865", "arg2_id": "1858", "normalized": [] }, { "id": "1940", "type": "CID", "arg1_id": "1865", "arg2_id": "1863", "normalized": [] }, { "id": "1941", "type": "CID", "arg1_id": "1865", "arg2_id": "1867", "normalized": [] }, { "id": "1942", "type": "CID", "arg1_id": "1865", "arg2_id": "1870", "normalized": [] }, { "id": "1943", "type": "CID", "arg1_id": "1865", "arg2_id": "1877", "normalized": [] }, { "id": "1944", "type": "CID", "arg1_id": "1868", "arg2_id": "1858", "normalized": [] }, { "id": "1945", "type": "CID", "arg1_id": "1868", "arg2_id": "1863", "normalized": [] }, { "id": "1946", "type": "CID", "arg1_id": "1868", "arg2_id": "1867", "normalized": [] }, { "id": "1947", "type": "CID", "arg1_id": "1868", "arg2_id": "1870", "normalized": [] }, { "id": "1948", "type": "CID", "arg1_id": "1868", "arg2_id": "1877", "normalized": [] }, { "id": "1949", "type": "CID", "arg1_id": "1871", "arg2_id": "1858", "normalized": [] }, { "id": "1950", "type": "CID", "arg1_id": "1871", "arg2_id": "1863", "normalized": [] }, { "id": "1951", "type": "CID", "arg1_id": "1871", "arg2_id": "1867", "normalized": [] }, { "id": "1952", "type": "CID", "arg1_id": "1871", "arg2_id": "1870", "normalized": [] }, { "id": "1953", "type": "CID", "arg1_id": "1871", "arg2_id": "1877", "normalized": [] }, { "id": "1954", "type": "CID", "arg1_id": "1872", "arg2_id": "1858", "normalized": [] }, { "id": "1955", "type": "CID", "arg1_id": "1872", "arg2_id": "1863", "normalized": [] }, { "id": "1956", "type": "CID", "arg1_id": "1872", "arg2_id": "1867", "normalized": [] }, { "id": "1957", "type": "CID", "arg1_id": "1872", "arg2_id": "1870", "normalized": [] }, { "id": "1958", "type": "CID", "arg1_id": "1872", "arg2_id": "1877", "normalized": [] }, { "id": "1959", "type": "CID", "arg1_id": "1875", "arg2_id": "1858", "normalized": [] }, { "id": "1960", "type": "CID", "arg1_id": "1875", "arg2_id": "1863", "normalized": [] }, { "id": "1961", "type": "CID", "arg1_id": "1875", "arg2_id": "1867", "normalized": [] }, { "id": "1962", "type": "CID", "arg1_id": "1875", "arg2_id": "1870", "normalized": [] }, { "id": "1963", "type": "CID", "arg1_id": "1875", "arg2_id": "1877", "normalized": [] } ]

[ { "id": "1965", "type": "title", "text": [ "Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat." ], "offsets": [ [ 0, 124 ] ] }, { "id": "1966", "type": "abstract", "text": [ "Immunohistochemistry with monoclonal antibodies against neurofilament (NF) proteins of middle and high molecular weight class, NF-M and NF-H, was used to study axonal injury in the borderzone of focal lesions in rats. Focal injury in the cortex was produced by infusion of lactate at acid pH or by stab caused by needle insertion. Infarcts in substantia nigra pars reticulata were evoked by prolonged pilocarpine-induced status epilepticus. Immunohistochemical staining for NFs showed characteristic terminal clubs of axons in the borderzone of lesions. Differences in the labelling pattern occurred with different antibodies which apparently depended on molecular weight class of NFs and phosphorylation state. These immunohistochemical changes of NFs can serve as a marker for axonal damage in various experimental traumatic or ischemic lesions." ], "offsets": [ [ 125, 972 ] ] } ]

[ { "id": "1967", "type": "Disease", "text": [ "axonal damage" ], "offsets": [ [ 73, 86 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "1968", "type": "Disease", "text": [ "axonal injury" ], "offsets": [ [ 285, 298 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "1969", "type": "Disease", "text": [ "injury in the cortex" ], "offsets": [ [ 349, 369 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "1970", "type": "Chemical", "text": [ "lactate" ], "offsets": [ [ 398, 405 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019344" } ] }, { "id": "1971", "type": "Disease", "text": [ "Infarcts in substantia nigra pars reticulata" ], "offsets": [ [ 456, 500 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002544" } ] }, { "id": "1972", "type": "Chemical", "text": [ "pilocarpine" ], "offsets": [ [ 526, 537 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010862" } ] }, { "id": "1973", "type": "Disease", "text": [ "status epilepticus" ], "offsets": [ [ 546, 564 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013226" } ] }, { "id": "1974", "type": "Disease", "text": [ "axonal damage" ], "offsets": [ [ 904, 917 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "1975", "type": "Disease", "text": [ "traumatic" ], "offsets": [ [ 942, 951 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014947" } ] } ]

[]

[]

[ { "id": "1976", "type": "CID", "arg1_id": "1972", "arg2_id": "1973", "normalized": [] }, { "id": "1977", "type": "CID", "arg1_id": "1972", "arg2_id": "1971", "normalized": [] }, { "id": "1978", "type": "CID", "arg1_id": "1972", "arg2_id": "1967", "normalized": [] }, { "id": "1979", "type": "CID", "arg1_id": "1972", "arg2_id": "1968", "normalized": [] }, { "id": "1980", "type": "CID", "arg1_id": "1972", "arg2_id": "1969", "normalized": [] }, { "id": "1981", "type": "CID", "arg1_id": "1972", "arg2_id": "1974", "normalized": [] } ]

[ { "id": "1983", "type": "title", "text": [ "Increase of Parkinson disability after fluoxetine medication." ], "offsets": [ [ 0, 61 ] ] }, { "id": "1984", "type": "abstract", "text": [ "Depression is a major clinical feature of Parkinson's disease. We report the increased amount of motor disability in four patients with idiopathic Parkinson's disease after exposure to the antidepressant fluoxetine. The possibility of a clinically relevant dopamine-antagonistic capacity of fluoxetine in Parkinson's disease patients must be considered." ], "offsets": [ [ 62, 415 ] ] } ]

[ { "id": "1985", "type": "Disease", "text": [ "Parkinson disability" ], "offsets": [ [ 12, 32 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009069" } ] }, { "id": "1986", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 39, 49 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "1987", "type": "Disease", "text": [ "Depression" ], "offsets": [ [ 62, 72 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "1988", "type": "Disease", "text": [ "Parkinson's disease" ], "offsets": [ [ 104, 123 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010300" } ] }, { "id": "1989", "type": "Disease", "text": [ "motor disability" ], "offsets": [ [ 159, 175 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009069" } ] }, { "id": "1990", "type": "Disease", "text": [ "idiopathic Parkinson's disease" ], "offsets": [ [ 198, 228 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010300" } ] }, { "id": "1991", "type": "Chemical", "text": [ "antidepressant" ], "offsets": [ [ 251, 265 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "1992", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 266, 276 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "1993", "type": "Chemical", "text": [ "dopamine" ], "offsets": [ [ 319, 327 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004298" } ] }, { "id": "1994", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 353, 363 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "1995", "type": "Disease", "text": [ "Parkinson's disease" ], "offsets": [ [ 367, 386 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010300" } ] } ]

[]

[]

[ { "id": "1996", "type": "CID", "arg1_id": "1986", "arg2_id": "1985", "normalized": [] }, { "id": "1997", "type": "CID", "arg1_id": "1986", "arg2_id": "1989", "normalized": [] }, { "id": "1998", "type": "CID", "arg1_id": "1992", "arg2_id": "1985", "normalized": [] }, { "id": "1999", "type": "CID", "arg1_id": "1992", "arg2_id": "1989", "normalized": [] }, { "id": "2000", "type": "CID", "arg1_id": "1994", "arg2_id": "1985", "normalized": [] }, { "id": "2001", "type": "CID", "arg1_id": "1994", "arg2_id": "1989", "normalized": [] } ]

[ { "id": "2003", "type": "title", "text": [ "Acetaminophen-induced hypotension." ], "offsets": [ [ 0, 34 ] ] }, { "id": "2004", "type": "abstract", "text": [ "Through 30 years of widespread use, acetaminophen has been shown to be a remarkably safe medication in therapeutic dosages. The potential for acetaminophen to produce cardiovascular toxicities is very low. However, acetaminophen has been demonstrated to produce symptoms of anaphylaxis, including hypotension, in sensitive individuals. This article describes two critically ill patients in whom transient episodes of hypotension reproducibly developed after administration of acetaminophen. Other symptoms of allergic reactions were not clinically detectable. The hypotensive episodes were severe enough to require vasopressor administration. The reports illustrate the need for clinicians to consider acetaminophen in patients with hypotension of unknown origin." ], "offsets": [ [ 35, 798 ] ] } ]

[ { "id": "2005", "type": "Chemical", "text": [ "Acetaminophen" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "2006", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 22, 33 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "2007", "type": "Chemical", "text": [ "acetaminophen" ], "offsets": [ [ 71, 84 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "2008", "type": "Chemical", "text": [ "acetaminophen" ], "offsets": [ [ 177, 190 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "2009", "type": "Disease", "text": [ "cardiovascular toxicities" ], "offsets": [ [ 202, 227 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002318" } ] }, { "id": "2010", "type": "Chemical", "text": [ "acetaminophen" ], "offsets": [ [ 250, 263 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "2011", "type": "Disease", "text": [ "anaphylaxis" ], "offsets": [ [ 309, 320 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000707" } ] }, { "id": "2012", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 332, 343 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "2013", "type": "Disease", "text": [ "critically ill" ], "offsets": [ [ 398, 412 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016638" } ] }, { "id": "2014", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 452, 463 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "2015", "type": "Chemical", "text": [ "acetaminophen" ], "offsets": [ [ 511, 524 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "2016", "type": "Disease", "text": [ "allergic reactions" ], "offsets": [ [ 544, 562 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004342" } ] }, { "id": "2017", "type": "Disease", "text": [ "hypotensive" ], "offsets": [ [ 599, 610 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "2018", "type": "Chemical", "text": [ "acetaminophen" ], "offsets": [ [ 737, 750 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "2019", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 768, 779 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] } ]

[]

[]

[ { "id": "2020", "type": "CID", "arg1_id": "2005", "arg2_id": "2006", "normalized": [] }, { "id": "2021", "type": "CID", "arg1_id": "2005", "arg2_id": "2012", "normalized": [] }, { "id": "2022", "type": "CID", "arg1_id": "2005", "arg2_id": "2014", "normalized": [] }, { "id": "2023", "type": "CID", "arg1_id": "2005", "arg2_id": "2017", "normalized": [] }, { "id": "2024", "type": "CID", "arg1_id": "2005", "arg2_id": "2019", "normalized": [] }, { "id": "2025", "type": "CID", "arg1_id": "2007", "arg2_id": "2006", "normalized": [] }, { "id": "2026", "type": "CID", "arg1_id": "2007", "arg2_id": "2012", "normalized": [] }, { "id": "2027", "type": "CID", "arg1_id": "2007", "arg2_id": "2014", "normalized": [] }, { "id": "2028", "type": "CID", "arg1_id": "2007", "arg2_id": "2017", "normalized": [] }, { "id": "2029", "type": "CID", "arg1_id": "2007", "arg2_id": "2019", "normalized": [] }, { "id": "2030", "type": "CID", "arg1_id": "2008", "arg2_id": "2006", "normalized": [] }, { "id": "2031", "type": "CID", "arg1_id": "2008", "arg2_id": "2012", "normalized": [] }, { "id": "2032", "type": "CID", "arg1_id": "2008", "arg2_id": "2014", "normalized": [] }, { "id": "2033", "type": "CID", "arg1_id": "2008", "arg2_id": "2017", "normalized": [] }, { "id": "2034", "type": "CID", "arg1_id": "2008", "arg2_id": "2019", "normalized": [] }, { "id": "2035", "type": "CID", "arg1_id": "2010", "arg2_id": "2006", "normalized": [] }, { "id": "2036", "type": "CID", "arg1_id": "2010", "arg2_id": "2012", "normalized": [] }, { "id": "2037", "type": "CID", "arg1_id": "2010", "arg2_id": "2014", "normalized": [] }, { "id": "2038", "type": "CID", "arg1_id": "2010", "arg2_id": "2017", "normalized": [] }, { "id": "2039", "type": "CID", "arg1_id": "2010", "arg2_id": "2019", "normalized": [] }, { "id": "2040", "type": "CID", "arg1_id": "2015", "arg2_id": "2006", "normalized": [] }, { "id": "2041", "type": "CID", "arg1_id": "2015", "arg2_id": "2012", "normalized": [] }, { "id": "2042", "type": "CID", "arg1_id": "2015", "arg2_id": "2014", "normalized": [] }, { "id": "2043", "type": "CID", "arg1_id": "2015", "arg2_id": "2017", "normalized": [] }, { "id": "2044", "type": "CID", "arg1_id": "2015", "arg2_id": "2019", "normalized": [] }, { "id": "2045", "type": "CID", "arg1_id": "2018", "arg2_id": "2006", "normalized": [] }, { "id": "2046", "type": "CID", "arg1_id": "2018", "arg2_id": "2012", "normalized": [] }, { "id": "2047", "type": "CID", "arg1_id": "2018", "arg2_id": "2014", "normalized": [] }, { "id": "2048", "type": "CID", "arg1_id": "2018", "arg2_id": "2017", "normalized": [] }, { "id": "2049", "type": "CID", "arg1_id": "2018", "arg2_id": "2019", "normalized": [] } ]

[ { "id": "2051", "type": "title", "text": [ "Acute hepatitis, autoimmune hemolytic anemia, and erythroblastocytopenia induced by ceftriaxone." ], "offsets": [ [ 0, 96 ] ] }, { "id": "2052", "type": "abstract", "text": [ "An 80-yr-old man developed acute hepatitis shortly after ingesting oral ceftriaxone. Although the transaminases gradually returned to baseline after withholding the beta lactam antibiotic, there was a gradual increase in serum bilirubin and a decrease in hemoglobin concentration caused by an autoimmune hemolytic anemia and erythroblastocytopenia. These responded to systemic steroids and immunoglobulins. Despite the widespread use of these agents this triad of side effects has not previously been reported in connection with beta lactam antibiotics." ], "offsets": [ [ 97, 650 ] ] } ]

[ { "id": "2053", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 6, 15 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "2054", "type": "Disease", "text": [ "autoimmune hemolytic anemia" ], "offsets": [ [ 17, 44 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000744" } ] }, { "id": "2055", "type": "Disease", "text": [ "erythroblastocytopenia" ], "offsets": [ [ 50, 72 ] ], "normalized": [] }, { "id": "2056", "type": "Chemical", "text": [ "ceftriaxone" ], "offsets": [ [ 84, 95 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002443" } ] }, { "id": "2057", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 130, 139 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "2058", "type": "Chemical", "text": [ "ceftriaxone" ], "offsets": [ [ 169, 180 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002443" } ] }, { "id": "2059", "type": "Chemical", "text": [ "beta lactam" ], "offsets": [ [ 262, 273 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D047090" } ] }, { "id": "2060", "type": "Chemical", "text": [ "bilirubin" ], "offsets": [ [ 324, 333 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001663" } ] }, { "id": "2061", "type": "Disease", "text": [ "autoimmune hemolytic anemia" ], "offsets": [ [ 390, 417 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000744" } ] }, { "id": "2062", "type": "Disease", "text": [ "erythroblastocytopenia" ], "offsets": [ [ 422, 444 ] ], "normalized": [] }, { "id": "2063", "type": "Chemical", "text": [ "steroids" ], "offsets": [ [ 474, 482 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013256" } ] }, { "id": "2064", "type": "Chemical", "text": [ "beta lactam" ], "offsets": [ [ 626, 637 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D047090" } ] } ]

[]

[]

[ { "id": "2065", "type": "CID", "arg1_id": "2056", "arg2_id": "2054", "normalized": [] }, { "id": "2066", "type": "CID", "arg1_id": "2056", "arg2_id": "2061", "normalized": [] }, { "id": "2067", "type": "CID", "arg1_id": "2058", "arg2_id": "2054", "normalized": [] }, { "id": "2068", "type": "CID", "arg1_id": "2058", "arg2_id": "2061", "normalized": [] }, { "id": "2069", "type": "CID", "arg1_id": "2056", "arg2_id": "2053", "normalized": [] }, { "id": "2070", "type": "CID", "arg1_id": "2056", "arg2_id": "2057", "normalized": [] }, { "id": "2071", "type": "CID", "arg1_id": "2058", "arg2_id": "2053", "normalized": [] }, { "id": "2072", "type": "CID", "arg1_id": "2058", "arg2_id": "2057", "normalized": [] } ]

[ { "id": "2074", "type": "title", "text": [ "Adverse effects of the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations." ], "offsets": [ [ 0, 106 ] ] }, { "id": "2075", "type": "abstract", "text": [ "Adverse effects of antipsychotics often lead to noncompliance. Thus, clinicians should address patients' concerns about adverse effects and attempt to choose medications that will improve their patients' quality of life as well as overall health. The side effect profiles of the atypical antipsychotics are more advantageous than those of the conventional neuroleptics. Conventional agents are associated with unwanted central nervous system effects, including extrapyramidal symptoms (EPS), tardive dyskinesia, sedation, and possible impairment of some cognitive measures, as well as cardiac effects, orthostatic hypotension, hepatic changes, anticholinergic side effects, sexual dysfunction, and weight gain. The newer atypical agents have a lower risk of EPS, but are associated in varying degrees with sedation, cardiovascular effects, anticholinergic effects, weight gain, sexual dysfunction, hepatic effects, lowered seizure threshold (primarily clozapine), and agranulocytosis (clozapine only). Since the incidence and severity of specific adverse effects differ among the various atypicals, the clinician should carefully consider which side effects are most likely to lead to the individual's dissatisfaction and noncompliance before choosing an antipsychotic for a particular patient." ], "offsets": [ [ 107, 1401 ] ] } ]

[ { "id": "2076", "type": "Disease", "text": [ "extrapyramidal symptoms" ], "offsets": [ [ 568, 591 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "2077", "type": "Disease", "text": [ "EPS" ], "offsets": [ [ 593, 596 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "2078", "type": "Disease", "text": [ "tardive dyskinesia" ], "offsets": [ [ 599, 617 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004409" } ] }, { "id": "2079", "type": "Disease", "text": [ "orthostatic hypotension" ], "offsets": [ [ 709, 732 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007024" } ] }, { "id": "2080", "type": "Disease", "text": [ "sexual dysfunction" ], "offsets": [ [ 781, 799 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012735" } ] }, { "id": "2081", "type": "Disease", "text": [ "weight gain" ], "offsets": [ [ 805, 816 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015430" } ] }, { "id": "2082", "type": "Disease", "text": [ "EPS" ], "offsets": [ [ 865, 868 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "2083", "type": "Disease", "text": [ "weight gain" ], "offsets": [ [ 972, 983 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015430" } ] }, { "id": "2084", "type": "Disease", "text": [ "sexual dysfunction" ], "offsets": [ [ 985, 1003 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012735" } ] }, { "id": "2085", "type": "Disease", "text": [ "seizure" ], "offsets": [ [ 1030, 1037 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012640" } ] }, { "id": "2086", "type": "Chemical", "text": [ "clozapine" ], "offsets": [ [ 1059, 1068 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003024" } ] }, { "id": "2087", "type": "Disease", "text": [ "agranulocytosis" ], "offsets": [ [ 1075, 1090 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000380" } ] }, { "id": "2088", "type": "Chemical", "text": [ "clozapine" ], "offsets": [ [ 1092, 1101 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003024" } ] } ]

[]

[]

[ { "id": "2089", "type": "CID", "arg1_id": "2086", "arg2_id": "2087", "normalized": [] }, { "id": "2090", "type": "CID", "arg1_id": "2088", "arg2_id": "2087", "normalized": [] } ]

[ { "id": "2092", "type": "title", "text": [ "Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human platelet aggregation." ], "offsets": [ [ 0, 107 ] ] }, { "id": "2093", "type": "abstract", "text": [ "Tetrandrine (TET) and fangchinoline (FAN) are two naturally occurring analogues with a bisbenzylisoquinoline structure. The present study was undertaken to investigate the effects of TET and FAN on the experimental thrombosis induced by collagen plus epinephrine (EP) in mice, and platelet aggregation and blood coagulation in vitro. In the in vivo study, the administration (50 mg/kg, i.p.) of TET and FAN in mice showed the inhibition of thrombosis by 55% and 35%, respectively, while acetylsalicylic acid (ASA, 50 mg/kg, i.p.), a positive control, showed only 30% inhibition. In the vitro human platelet aggregations induced by the agonists used in tests, TET and FAN showed the inhibitions dose dependently. In addition, neither TET nor FAN showed any anticoagulation activities in the measurement of the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) using human-citrated plasma. These results suggest that antithrombosis of TET and FAN in mice may be mainly related to the antiplatelet aggregation activities." ], "offsets": [ [ 108, 1167 ] ] } ]

[ { "id": "2094", "type": "Chemical", "text": [ "tetrandrine" ], "offsets": [ [ 11, 22 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C009438" } ] }, { "id": "2095", "type": "Chemical", "text": [ "fangchinoline" ], "offsets": [ [ 27, 40 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C060802" } ] }, { "id": "2096", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 57, 67 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "2097", "type": "Disease", "text": [ "platelet aggregation" ], "offsets": [ [ 86, 106 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001791" } ] }, { "id": "2098", "type": "Chemical", "text": [ "Tetrandrine" ], "offsets": [ [ 108, 119 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C009438" } ] }, { "id": "2099", "type": "Chemical", "text": [ "TET" ], "offsets": [ [ 121, 124 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C009438" } ] }, { "id": "2100", "type": "Chemical", "text": [ "fangchinoline" ], "offsets": [ [ 130, 143 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C060802" } ] }, { "id": "2101", "type": "Chemical", "text": [ "FAN" ], "offsets": [ [ 145, 148 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C060802" } ] }, { "id": "2102", "type": "Chemical", "text": [ "bisbenzylisoquinoline" ], "offsets": [ [ 195, 216 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D044182" } ] }, { "id": "2103", "type": "Chemical", "text": [ "TET" ], "offsets": [ [ 291, 294 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C009438" } ] }, { "id": "2104", "type": "Chemical", "text": [ "FAN" ], "offsets": [ [ 299, 302 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C060802" } ] }, { "id": "2105", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 323, 333 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "2106", "type": "Chemical", "text": [ "epinephrine" ], "offsets": [ [ 359, 370 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004837" } ] }, { "id": "2107", "type": "Chemical", "text": [ "EP" ], "offsets": [ [ 372, 374 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004837" } ] }, { "id": "2108", "type": "Disease", "text": [ "platelet aggregation" ], "offsets": [ [ 389, 409 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001791" } ] }, { "id": "2109", "type": "Disease", "text": [ "blood coagulation" ], "offsets": [ [ 414, 431 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001778" } ] }, { "id": "2110", "type": "Chemical", "text": [ "TET" ], "offsets": [ [ 503, 506 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C009438" } ] }, { "id": "2111", "type": "Chemical", "text": [ "FAN" ], "offsets": [ [ 511, 514 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C060802" } ] }, { "id": "2112", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 548, 558 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "2113", "type": "Chemical", "text": [ "acetylsalicylic acid" ], "offsets": [ [ 595, 615 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "2114", "type": "Chemical", "text": [ "ASA" ], "offsets": [ [ 617, 620 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "2115", "type": "Disease", "text": [ "platelet aggregations" ], "offsets": [ [ 706, 727 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001791" } ] }, { "id": "2116", "type": "Chemical", "text": [ "TET" ], "offsets": [ [ 767, 770 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C009438" } ] }, { "id": "2117", "type": "Chemical", "text": [ "FAN" ], "offsets": [ [ 775, 778 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C060802" } ] }, { "id": "2118", "type": "Chemical", "text": [ "TET" ], "offsets": [ [ 841, 844 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C009438" } ] }, { "id": "2119", "type": "Chemical", "text": [ "FAN" ], "offsets": [ [ 849, 852 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C060802" } ] }, { "id": "2120", "type": "Chemical", "text": [ "TET" ], "offsets": [ [ 1082, 1085 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C009438" } ] }, { "id": "2121", "type": "Chemical", "text": [ "FAN" ], "offsets": [ [ 1090, 1093 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C060802" } ] } ]

[]

[]

[ { "id": "2122", "type": "CID", "arg1_id": "2106", "arg2_id": "2096", "normalized": [] }, { "id": "2123", "type": "CID", "arg1_id": "2106", "arg2_id": "2105", "normalized": [] }, { "id": "2124", "type": "CID", "arg1_id": "2106", "arg2_id": "2112", "normalized": [] }, { "id": "2125", "type": "CID", "arg1_id": "2107", "arg2_id": "2096", "normalized": [] }, { "id": "2126", "type": "CID", "arg1_id": "2107", "arg2_id": "2105", "normalized": [] }, { "id": "2127", "type": "CID", "arg1_id": "2107", "arg2_id": "2112", "normalized": [] } ]

[ { "id": "2129", "type": "title", "text": [ "Gemcitabine plus vinorelbine in nonsmall cell lung carcinoma patients age 70 years or older or patients who cannot receive cisplatin. Oncopaz Cooperative Group." ], "offsets": [ [ 0, 160 ] ] }, { "id": "2130", "type": "abstract", "text": [ "BACKGROUND: Although the prevalence of nonsmall cell lung carcinoma (NSCLC) is high among elderly patients, few data are available regarding the efficacy and toxicity of chemotherapy in this group of patients. Recent reports indicate that single agent therapy with vinorelbine (VNB) or gemcitabine (GEM) may obtain a response rate of 20-30% in elderly patients, with acceptable toxicity and improvement in symptoms and quality of life. In the current study the efficacy and toxicity of the combination of GEM and VNB in elderly patients with advanced NSCLC or those with some contraindication to receiving cisplatin were assessed. METHODS: Forty-nine patients with advanced NSCLC were included, 38 of whom were age >/= 70 years and 11 were age < 70 years but who had some contraindication to receiving cisplatin. All patients were evaluable for response and toxicity. Treatment was comprised of VNB, 25 mg/m(2), plus GEM, 1000 mg/m(2), both on Days 1, 8, and 15 every 28 days. Patients received a minimum of three courses unless progressive disease was detected. RESULTS: One hundred sixty-five courses were administered, with a median of 3. 6 courses per patient. The overall response rate was 26% (95% confidence interval, 15-41%). Two patients attained a complete response (4%) and 11 patients (22%) achieved a partial response. Eastern Cooperative Oncology Group performance status improved in 35% of those patients with an initial value > 0, whereas relief of at least 1 symptom without worsening of other symptoms was noted in 27 patients (55%). The median time to progression was 16 weeks and the 1-year survival rate was 33%. Toxicity was mild. Six patients (12%) had World Health Organization Grade 3-4 neutropenia, 2 patients (4%) had Grade 3-4 thrombocytopenia, and 2 patients (4%) had Grade 3 neurotoxicity. Three patients with severe neutropenia (6%) died of sepsis. The median age of those patients developing Grade 3-4 neutropenia was significantly higher than that of the remaining patients (75 years vs. 72 years; P = 0.047). CONCLUSIONS: The combination of GEM and VNB is moderately active and well tolerated except in patients age >/= 75 years. This age group had an increased risk of myelosuppression. Therefore the prophylactic use of granulocyte-colony stimulating factor should be considered with this treatment. New chemotherapy combinations with higher activity and lower toxicity are needed for elderly patients with advanced NSCLC." ], "offsets": [ [ 161, 2619 ] ] } ]

[ { "id": "2131", "type": "Chemical", "text": [ "Gemcitabine" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C056507" } ] }, { "id": "2132", "type": "Chemical", "text": [ "vinorelbine" ], "offsets": [ [ 17, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C030852" } ] }, { "id": "2133", "type": "Disease", "text": [ "nonsmall cell lung carcinoma" ], "offsets": [ [ 32, 60 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002289" } ] }, { "id": "2134", "type": "Chemical", "text": [ "cisplatin" ], "offsets": [ [ 123, 132 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002945" } ] }, { "id": "2135", "type": "Disease", "text": [ "nonsmall cell lung carcinoma" ], "offsets": [ [ 200, 228 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002289" } ] }, { "id": "2136", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 230, 235 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002289" } ] }, { "id": "2137", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 319, 327 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "2138", "type": "Chemical", "text": [ "vinorelbine" ], "offsets": [ [ 426, 437 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C030852" } ] }, { "id": "2139", "type": "Chemical", "text": [ "VNB" ], "offsets": [ [ 439, 442 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C030852" } ] }, { "id": "2140", "type": "Chemical", "text": [ "gemcitabine" ], "offsets": [ [ 447, 458 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C056507" } ] }, { "id": "2141", "type": "Chemical", "text": [ "GEM" ], "offsets": [ [ 460, 463 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C056507" } ] }, { "id": "2142", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 539, 547 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "2143", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 635, 643 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "2144", "type": "Chemical", "text": [ "GEM" ], "offsets": [ [ 666, 669 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C056507" } ] }, { "id": "2145", "type": "Chemical", "text": [ "VNB" ], "offsets": [ [ 674, 677 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C030852" } ] }, { "id": "2146", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 712, 717 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002289" } ] }, { "id": "2147", "type": "Chemical", "text": [ "cisplatin" ], "offsets": [ [ 767, 776 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002945" } ] }, { "id": "2148", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 835, 840 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002289" } ] }, { "id": "2149", "type": "Chemical", "text": [ "cisplatin" ], "offsets": [ [ 963, 972 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002945" } ] }, { "id": "2150", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 1019, 1027 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "2151", "type": "Chemical", "text": [ "VNB" ], "offsets": [ [ 1056, 1059 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C030852" } ] }, { "id": "2152", "type": "Chemical", "text": [ "GEM" ], "offsets": [ [ 1078, 1081 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C056507" } ] }, { "id": "2153", "type": "Disease", "text": [ "Toxicity" ], "offsets": [ [ 1795, 1803 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "2154", "type": "Disease", "text": [ "neutropenia" ], "offsets": [ [ 1873, 1884 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009503" } ] }, { "id": "2155", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 1916, 1932 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "2156", "type": "Disease", "text": [ "neurotoxicity" ], "offsets": [ [ 1966, 1979 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020258" } ] }, { "id": "2157", "type": "Disease", "text": [ "neutropenia" ], "offsets": [ [ 2008, 2019 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009503" } ] }, { "id": "2158", "type": "Disease", "text": [ "sepsis" ], "offsets": [ [ 2033, 2039 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018805" } ] }, { "id": "2159", "type": "Disease", "text": [ "neutropenia" ], "offsets": [ [ 2095, 2106 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009503" } ] }, { "id": "2160", "type": "Chemical", "text": [ "GEM" ], "offsets": [ [ 2236, 2239 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C056507" } ] }, { "id": "2161", "type": "Chemical", "text": [ "VNB" ], "offsets": [ [ 2244, 2247 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C030852" } ] }, { "id": "2162", "type": "Disease", "text": [ "myelosuppression" ], "offsets": [ [ 2365, 2381 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001855" } ] }, { "id": "2163", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 2558, 2566 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "2164", "type": "Disease", "text": [ "NSCLC" ], "offsets": [ [ 2613, 2618 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002289" } ] } ]

[]

[]

[ { "id": "2165", "type": "CID", "arg1_id": "2131", "arg2_id": "2155", "normalized": [] }, { "id": "2166", "type": "CID", "arg1_id": "2140", "arg2_id": "2155", "normalized": [] }, { "id": "2167", "type": "CID", "arg1_id": "2141", "arg2_id": "2155", "normalized": [] }, { "id": "2168", "type": "CID", "arg1_id": "2144", "arg2_id": "2155", "normalized": [] }, { "id": "2169", "type": "CID", "arg1_id": "2152", "arg2_id": "2155", "normalized": [] }, { "id": "2170", "type": "CID", "arg1_id": "2160", "arg2_id": "2155", "normalized": [] }, { "id": "2171", "type": "CID", "arg1_id": "2132", "arg2_id": "2155", "normalized": [] }, { "id": "2172", "type": "CID", "arg1_id": "2138", "arg2_id": "2155", "normalized": [] }, { "id": "2173", "type": "CID", "arg1_id": "2139", "arg2_id": "2155", "normalized": [] }, { "id": "2174", "type": "CID", "arg1_id": "2145", "arg2_id": "2155", "normalized": [] }, { "id": "2175", "type": "CID", "arg1_id": "2151", "arg2_id": "2155", "normalized": [] }, { "id": "2176", "type": "CID", "arg1_id": "2161", "arg2_id": "2155", "normalized": [] }, { "id": "2177", "type": "CID", "arg1_id": "2131", "arg2_id": "2156", "normalized": [] }, { "id": "2178", "type": "CID", "arg1_id": "2140", "arg2_id": "2156", "normalized": [] }, { "id": "2179", "type": "CID", "arg1_id": "2141", "arg2_id": "2156", "normalized": [] }, { "id": "2180", "type": "CID", "arg1_id": "2144", "arg2_id": "2156", "normalized": [] }, { "id": "2181", "type": "CID", "arg1_id": "2152", "arg2_id": "2156", "normalized": [] }, { "id": "2182", "type": "CID", "arg1_id": "2160", "arg2_id": "2156", "normalized": [] }, { "id": "2183", "type": "CID", "arg1_id": "2132", "arg2_id": "2154", "normalized": [] }, { "id": "2184", "type": "CID", "arg1_id": "2132", "arg2_id": "2157", "normalized": [] }, { "id": "2185", "type": "CID", "arg1_id": "2132", "arg2_id": "2159", "normalized": [] }, { "id": "2186", "type": "CID", "arg1_id": "2138", "arg2_id": "2154", "normalized": [] }, { "id": "2187", "type": "CID", "arg1_id": "2138", "arg2_id": "2157", "normalized": [] }, { "id": "2188", "type": "CID", "arg1_id": "2138", "arg2_id": "2159", "normalized": [] }, { "id": "2189", "type": "CID", "arg1_id": "2139", "arg2_id": "2154", "normalized": [] }, { "id": "2190", "type": "CID", "arg1_id": "2139", "arg2_id": "2157", "normalized": [] }, { "id": "2191", "type": "CID", "arg1_id": "2139", "arg2_id": "2159", "normalized": [] }, { "id": "2192", "type": "CID", "arg1_id": "2145", "arg2_id": "2154", "normalized": [] }, { "id": "2193", "type": "CID", "arg1_id": "2145", "arg2_id": "2157", "normalized": [] }, { "id": "2194", "type": "CID", "arg1_id": "2145", "arg2_id": "2159", "normalized": [] }, { "id": "2195", "type": "CID", "arg1_id": "2151", "arg2_id": "2154", "normalized": [] }, { "id": "2196", "type": "CID", "arg1_id": "2151", "arg2_id": "2157", "normalized": [] }, { "id": "2197", "type": "CID", "arg1_id": "2151", "arg2_id": "2159", "normalized": [] }, { "id": "2198", "type": "CID", "arg1_id": "2161", "arg2_id": "2154", "normalized": [] }, { "id": "2199", "type": "CID", "arg1_id": "2161", "arg2_id": "2157", "normalized": [] }, { "id": "2200", "type": "CID", "arg1_id": "2161", "arg2_id": "2159", "normalized": [] }, { "id": "2201", "type": "CID", "arg1_id": "2131", "arg2_id": "2154", "normalized": [] }, { "id": "2202", "type": "CID", "arg1_id": "2131", "arg2_id": "2157", "normalized": [] }, { "id": "2203", "type": "CID", "arg1_id": "2131", "arg2_id": "2159", "normalized": [] }, { "id": "2204", "type": "CID", "arg1_id": "2140", "arg2_id": "2154", "normalized": [] }, { "id": "2205", "type": "CID", "arg1_id": "2140", "arg2_id": "2157", "normalized": [] }, { "id": "2206", "type": "CID", "arg1_id": "2140", "arg2_id": "2159", "normalized": [] }, { "id": "2207", "type": "CID", "arg1_id": "2141", "arg2_id": "2154", "normalized": [] }, { "id": "2208", "type": "CID", "arg1_id": "2141", "arg2_id": "2157", "normalized": [] }, { "id": "2209", "type": "CID", "arg1_id": "2141", "arg2_id": "2159", "normalized": [] }, { "id": "2210", "type": "CID", "arg1_id": "2144", "arg2_id": "2154", "normalized": [] }, { "id": "2211", "type": "CID", "arg1_id": "2144", "arg2_id": "2157", "normalized": [] }, { "id": "2212", "type": "CID", "arg1_id": "2144", "arg2_id": "2159", "normalized": [] }, { "id": "2213", "type": "CID", "arg1_id": "2152", "arg2_id": "2154", "normalized": [] }, { "id": "2214", "type": "CID", "arg1_id": "2152", "arg2_id": "2157", "normalized": [] }, { "id": "2215", "type": "CID", "arg1_id": "2152", "arg2_id": "2159", "normalized": [] }, { "id": "2216", "type": "CID", "arg1_id": "2160", "arg2_id": "2154", "normalized": [] }, { "id": "2217", "type": "CID", "arg1_id": "2160", "arg2_id": "2157", "normalized": [] }, { "id": "2218", "type": "CID", "arg1_id": "2160", "arg2_id": "2159", "normalized": [] }, { "id": "2219", "type": "CID", "arg1_id": "2132", "arg2_id": "2156", "normalized": [] }, { "id": "2220", "type": "CID", "arg1_id": "2138", "arg2_id": "2156", "normalized": [] }, { "id": "2221", "type": "CID", "arg1_id": "2139", "arg2_id": "2156", "normalized": [] }, { "id": "2222", "type": "CID", "arg1_id": "2145", "arg2_id": "2156", "normalized": [] }, { "id": "2223", "type": "CID", "arg1_id": "2151", "arg2_id": "2156", "normalized": [] }, { "id": "2224", "type": "CID", "arg1_id": "2161", "arg2_id": "2156", "normalized": [] } ]

[ { "id": "2226", "type": "title", "text": [ "Warfarin-induced artery calcification is accelerated by growth and vitamin D." ], "offsets": [ [ 0, 77 ] ] }, { "id": "2227", "type": "abstract", "text": [ "The present studies demonstrate that growth and vitamin D treatment enhance the extent of artery calcification in rats given sufficient doses of Warfarin to inhibit gamma-carboxylation of matrix Gla protein, a calcification inhibitor known to be expressed by smooth muscle cells and macrophages in the artery wall. The first series of experiments examined the influence of age and growth status on artery calcification in Warfarin-treated rats. Treatment for 2 weeks with Warfarin caused massive focal calcification of the artery media in 20-day-old rats and less extensive focal calcification in 42-day-old rats. In contrast, no artery calcification could be detected in 10-month-old adult rats even after 4 weeks of Warfarin treatment. To directly examine the importance of growth to Warfarin-induced artery calcification in animals of the same age, 20-day-old rats were fed for 2 weeks either an ad libitum diet or a 6-g/d restricted diet that maintains weight but prevents growth. Concurrent treatment of both dietary groups with Warfarin produced massive focal calcification of the artery media in the ad libitum-fed rats but no detectable artery calcification in the restricted-diet, growth-inhibited group. Although the explanation for the association between artery calcification and growth status cannot be determined from the present study, there was a relationship between higher serum phosphate and susceptibility to artery calcification, with 30% higher levels of serum phosphate in young, ad libitum-fed rats compared with either of the groups that was resistant to Warfarin-induced artery calcification, ie, the 10-month-old rats and the restricted-diet, growth-inhibited young rats. This observation suggests that increased susceptibility to Warfarin-induced artery calcification could be related to higher serum phosphate levels. The second set of experiments examined the possible synergy between vitamin D and Warfarin in artery calcification. High doses of vitamin D are known to cause calcification of the artery media in as little as 3 to 4 days. High doses of the vitamin K antagonist Warfarin are also known to cause calcification of the artery media, but at treatment times of 2 weeks or longer yet not at 1 week. In the current study, we investigated the synergy between these 2 treatments and found that concurrent Warfarin administration dramatically increased the extent of calcification in the media of vitamin D-treated rats at 3 and 4 days. There was a close parallel between the effect of vitamin D dose on artery calcification and the effect of vitamin D dose on the elevation of serum calcium, which suggests that vitamin D may induce artery calcification through its effect on serum calcium. Because Warfarin treatment had no effect on the elevation in serum calcium produced by vitamin D, the synergy between Warfarin and vitamin D is probably best explained by the hypothesis that Warfarin inhibits the activity of matrix Gla protein as a calcification inhibitor. High levels of matrix Gla protein are found at sites of artery calcification in rats treated with vitamin D plus Warfarin, and chemical analysis showed that the protein that accumulated was indeed not gamma-carboxylated. These observations indicate that although the gamma-carboxyglutamate residues of matrix Gla protein are apparently required for its function as a calcification inhibitor, they are not required for its accumulation at calcification sites." ], "offsets": [ [ 78, 3538 ] ] } ]

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"offsets": [ [ 288, 301 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002114" } ] }, { "id": "2235", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 476, 496 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2236", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 500, 508 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2237", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 550, 558 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2238", "type": "Disease", "text": [ "calcification of the artery" ], "offsets": [ [ 580, 607 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2239", "type": "Disease", "text": [ "calcification" ], "offsets": [ [ 658, 671 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002114" } ] }, { "id": "2240", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 708, 728 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2241", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 796, 804 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2242", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 864, 872 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2243", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 881, 901 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2244", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 1112, 1120 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2245", "type": "Disease", "text": [ "calcification of the artery" ], "offsets": [ [ 1144, 1171 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2246", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 1223, 1243 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2247", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 1345, 1365 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2248", "type": "Chemical", "text": [ "phosphate" ], "offsets": [ [ 1475, 1484 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010710" } ] }, { "id": "2249", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 1507, 1527 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2250", "type": "Chemical", "text": [ "phosphate" ], "offsets": [ [ 1561, 1570 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010710" } ] }, { "id": "2251", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 1658, 1666 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2252", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 1675, 1695 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2253", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 1836, 1844 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2254", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 1853, 1873 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2255", "type": "Chemical", "text": [ "phosphate" ], "offsets": [ [ 1907, 1916 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010710" } ] }, { "id": "2256", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 1993, 2002 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2257", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 2007, 2015 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2258", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 2019, 2039 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2259", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 2055, 2064 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2260", "type": "Disease", "text": [ "calcification of the artery" ], "offsets": [ [ 2084, 2111 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2261", "type": "Chemical", "text": [ "vitamin K" ], "offsets": [ [ 2165, 2174 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014812" } ] }, { "id": "2262", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 2186, 2194 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2263", "type": "Disease", "text": [ "calcification of the artery" ], "offsets": [ [ 2219, 2246 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2264", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 2420, 2428 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2265", "type": "Disease", "text": [ "calcification" ], "offsets": [ [ 2481, 2494 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002114" } ] }, { "id": "2266", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 2511, 2520 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2267", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 2600, 2609 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2268", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 2618, 2638 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2269", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 2657, 2666 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2270", "type": "Chemical", "text": [ "calcium" ], "offsets": [ [ 2698, 2705 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002118" } ] }, { "id": "2271", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 2727, 2736 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2272", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 2748, 2768 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2273", "type": "Chemical", "text": [ "calcium" ], "offsets": [ [ 2797, 2804 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002118" } ] }, { "id": "2274", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 2814, 2822 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2275", "type": "Chemical", "text": [ "calcium" ], "offsets": [ [ 2873, 2880 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002118" } ] }, { "id": "2276", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 2893, 2902 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2277", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 2924, 2932 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2278", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 2937, 2946 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2279", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 2997, 3005 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2280", "type": "Disease", "text": [ "calcification" ], "offsets": [ [ 3055, 3068 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002114" } ] }, { "id": "2281", "type": "Disease", "text": [ "artery calcification" ], "offsets": [ [ 3136, 3156 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D061205" } ] }, { "id": "2282", "type": "Chemical", "text": [ "vitamin D" ], "offsets": [ [ 3178, 3187 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014807" } ] }, { "id": "2283", "type": "Chemical", "text": [ "Warfarin" ], "offsets": [ [ 3193, 3201 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014859" } ] }, { "id": "2284", "type": "Chemical", "text": [ "gamma-carboxylated" ], "offsets": [ [ 3281, 3299 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015055" } ] }, { "id": "2285", "type": "Chemical", "text": [ "gamma-carboxyglutamate" ], "offsets": [ [ 3347, 3369 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015055" } ] }, { "id": "2286", "type": "Disease", "text": [ "calcification" ], "offsets": [ [ 3447, 3460 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002114" } ] }, { "id": "2287", "type": "Disease", "text": [ "calcification" ], "offsets": [ [ 3518, 3531 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002114" } ] } ]

[]

[]

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"id": "2546", "type": "CID", "arg1_id": "2279", "arg2_id": "2245", "normalized": [] }, { "id": "2547", "type": "CID", "arg1_id": "2279", "arg2_id": "2246", "normalized": [] }, { "id": "2548", "type": "CID", "arg1_id": "2279", "arg2_id": "2247", "normalized": [] }, { "id": "2549", "type": "CID", "arg1_id": "2279", "arg2_id": "2249", "normalized": [] }, { "id": "2550", "type": "CID", "arg1_id": "2279", "arg2_id": "2252", "normalized": [] }, { "id": "2551", "type": "CID", "arg1_id": "2279", "arg2_id": "2254", "normalized": [] }, { "id": "2552", "type": "CID", "arg1_id": "2279", "arg2_id": "2258", "normalized": [] }, { "id": "2553", "type": "CID", "arg1_id": "2279", "arg2_id": "2260", "normalized": [] }, { "id": "2554", "type": "CID", "arg1_id": "2279", "arg2_id": "2263", "normalized": [] }, { "id": "2555", "type": "CID", "arg1_id": "2279", "arg2_id": "2268", "normalized": [] }, { "id": "2556", "type": "CID", "arg1_id": "2279", "arg2_id": "2272", "normalized": [] }, { "id": "2557", "type": "CID", "arg1_id": "2279", "arg2_id": "2281", "normalized": [] }, { "id": "2558", "type": "CID", "arg1_id": "2283", "arg2_id": "2229", "normalized": [] }, { "id": "2559", "type": "CID", "arg1_id": "2283", "arg2_id": "2232", "normalized": [] }, { "id": "2560", "type": "CID", "arg1_id": "2283", "arg2_id": "2235", "normalized": [] }, { "id": "2561", "type": "CID", "arg1_id": "2283", "arg2_id": "2238", "normalized": [] }, { "id": "2562", "type": "CID", "arg1_id": "2283", "arg2_id": "2240", "normalized": [] }, { "id": "2563", "type": "CID", "arg1_id": "2283", "arg2_id": "2243", "normalized": [] }, { "id": "2564", "type": "CID", "arg1_id": "2283", "arg2_id": "2245", "normalized": [] }, { "id": "2565", "type": "CID", "arg1_id": "2283", "arg2_id": "2246", "normalized": [] }, { "id": "2566", "type": "CID", "arg1_id": "2283", "arg2_id": "2247", "normalized": [] }, { "id": "2567", "type": "CID", "arg1_id": "2283", "arg2_id": "2249", "normalized": [] }, { "id": "2568", "type": "CID", "arg1_id": "2283", "arg2_id": "2252", "normalized": [] }, { "id": "2569", "type": "CID", "arg1_id": "2283", "arg2_id": "2254", "normalized": [] }, { "id": "2570", "type": "CID", "arg1_id": "2283", "arg2_id": "2258", "normalized": [] }, { "id": "2571", "type": "CID", "arg1_id": "2283", "arg2_id": "2260", "normalized": [] }, { "id": "2572", "type": "CID", "arg1_id": "2283", "arg2_id": "2263", "normalized": [] }, { "id": "2573", "type": "CID", "arg1_id": "2283", "arg2_id": "2268", "normalized": [] }, { "id": "2574", "type": "CID", "arg1_id": "2283", "arg2_id": "2272", "normalized": [] }, { "id": "2575", "type": "CID", "arg1_id": "2283", "arg2_id": "2281", "normalized": [] } ]

[ { "id": "2577", "type": "title", "text": [ "Antidepressant-induced mania in bipolar patients: identification of risk factors." ], "offsets": [ [ 0, 81 ] ] }, { "id": "2578", "type": "abstract", "text": [ "BACKGROUND: Concerns about possible risks of switching to mania associated with antidepressants continue to interfere with the establishment of an optimal treatment paradigm for bipolar depression. METHOD: The response of 44 patients meeting DSM-IV criteria for bipolar disorder to naturalistic treatment was assessed for at least 6 weeks using the Montgomery-Asberg Depression Rating Scale and the Bech-Rafaelson Mania Rating Scale. Patients who experienced a manic or hypomanic switch were compared with those who did not on several variables including age, sex, diagnosis (DSM-IV bipolar I vs. bipolar II), number of previous manic episodes, type of antidepressant therapy used (electroconvulsive therapy vs. antidepressant drugs and, more particularly, selective serotonin reuptake inhibitors [SSRIs]), use and type of mood stabilizers (lithium vs. anticonvulsants), and temperament of the patient, assessed during a normothymic period using the hyperthymia component of the Semi-structured Affective Temperament Interview. RESULTS: Switches to hypomania or mania occurred in 27% of all patients (N = 12) (and in 24% of the subgroup of patients treated with SSRIs [8/33]); 16% (N = 7) experienced manic episodes, and 11% (N = 5) experienced hypomanic episodes. Sex, age, diagnosis (bipolar I vs. bipolar II), and additional treatment did not affect the risk of switching. The incidence of mood switches seemed not to differ between patients receiving an anticonvulsant and those receiving no mood stabilizer. In contrast, mood switches were less frequent in patients receiving lithium (15%, 4/26) than in patients not treated with lithium (44%, 8/18; p = .04). The number of previous manic episodes did not affect the probability of switching, whereas a high score on the hyperthymia component of the Semistructured Affective Temperament Interview was associated with a greater risk of switching (p = .008). CONCLUSION: The frequency of mood switching associated with acute antidepressant therapy may be reduced by lithium treatment. Particular attention should be paid to patients with a hyperthymic temperament, who have a greater risk of mood switches." ], "offsets": [ [ 82, 2241 ] ] } ]

[ { "id": "2579", "type": "Chemical", "text": [ "Antidepressant" ], "offsets": [ [ 0, 14 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "2580", "type": "Disease", "text": [ "mania" ], "offsets": [ [ 23, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2581", "type": "Disease", "text": [ "bipolar" ], "offsets": [ [ 32, 39 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2582", "type": "Disease", "text": [ "mania" ], "offsets": [ [ 140, 145 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2583", "type": "Chemical", "text": [ "antidepressants" ], "offsets": [ [ 162, 177 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "2584", "type": "Disease", "text": [ "bipolar depression" ], "offsets": [ [ 260, 278 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2585", "type": "Disease", "text": [ "bipolar disorder" ], "offsets": [ [ 344, 360 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2586", "type": "Disease", "text": [ "manic" ], "offsets": [ [ 543, 548 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2587", "type": "Disease", "text": [ "hypomanic" ], "offsets": [ [ 552, 561 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2588", "type": "Disease", "text": [ "DSM-IV bipolar I" ], "offsets": [ [ 658, 674 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2589", "type": "Disease", "text": [ "bipolar II" ], "offsets": [ [ 679, 689 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2590", "type": "Disease", "text": [ "manic" ], "offsets": [ [ 711, 716 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2591", "type": "Chemical", "text": [ "antidepressant" ], "offsets": [ [ 735, 749 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "2592", "type": "Chemical", "text": [ "antidepressant" ], "offsets": [ [ 794, 808 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "2593", "type": "Chemical", "text": [ "serotonin reuptake inhibitors" ], "offsets": [ [ 849, 878 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017367" } ] }, { "id": "2594", "type": "Chemical", "text": [ "SSRIs" ], "offsets": [ [ 880, 885 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017367" } ] }, { "id": "2595", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 923, 930 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "2596", "type": "Disease", "text": [ "hypomania" ], "offsets": [ [ 1131, 1140 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2597", "type": "Disease", "text": [ "mania" ], "offsets": [ [ 1144, 1149 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2598", "type": "Chemical", "text": [ "SSRIs" ], "offsets": [ [ 1244, 1249 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017367" } ] }, { "id": "2599", "type": "Disease", "text": [ "manic" ], "offsets": [ [ 1283, 1288 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2600", "type": "Disease", "text": [ "hypomanic" ], "offsets": [ [ 1327, 1336 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2601", "type": "Disease", "text": [ "bipolar I" ], "offsets": [ [ 1368, 1377 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2602", "type": "Disease", "text": [ "bipolar II" ], "offsets": [ [ 1382, 1392 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2603", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 1663, 1670 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "2604", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 1717, 1724 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "2605", "type": "Disease", "text": [ "manic" ], "offsets": [ [ 1770, 1775 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001714" } ] }, { "id": "2606", "type": "Chemical", "text": [ "antidepressant" ], "offsets": [ [ 2060, 2074 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "2607", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 2101, 2108 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] } ]

[]

[]

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"arg2_id": "2605", "normalized": [] }, { "id": "2642", "type": "CID", "arg1_id": "2591", "arg2_id": "2580", "normalized": [] }, { "id": "2643", "type": "CID", "arg1_id": "2591", "arg2_id": "2581", "normalized": [] }, { "id": "2644", "type": "CID", "arg1_id": "2591", "arg2_id": "2582", "normalized": [] }, { "id": "2645", "type": "CID", "arg1_id": "2591", "arg2_id": "2584", "normalized": [] }, { "id": "2646", "type": "CID", "arg1_id": "2591", "arg2_id": "2585", "normalized": [] }, { "id": "2647", "type": "CID", "arg1_id": "2591", "arg2_id": "2586", "normalized": [] }, { "id": "2648", "type": "CID", "arg1_id": "2591", "arg2_id": "2587", "normalized": [] }, { "id": "2649", "type": "CID", "arg1_id": "2591", "arg2_id": "2588", "normalized": [] }, { "id": "2650", "type": "CID", "arg1_id": "2591", "arg2_id": "2589", "normalized": [] }, { "id": "2651", "type": "CID", "arg1_id": "2591", "arg2_id": "2590", "normalized": [] }, { "id": "2652", "type": "CID", "arg1_id": "2591", "arg2_id": "2596", "normalized": [] }, { "id": "2653", "type": "CID", "arg1_id": "2591", "arg2_id": "2597", "normalized": [] }, { "id": "2654", "type": "CID", "arg1_id": "2591", "arg2_id": "2599", "normalized": [] }, { "id": "2655", "type": "CID", "arg1_id": "2591", "arg2_id": "2600", "normalized": [] }, { "id": "2656", "type": "CID", "arg1_id": "2591", "arg2_id": "2601", "normalized": [] }, { "id": "2657", "type": "CID", "arg1_id": "2591", "arg2_id": "2602", "normalized": [] }, { "id": "2658", "type": "CID", "arg1_id": "2591", "arg2_id": "2605", "normalized": [] }, { "id": "2659", "type": "CID", "arg1_id": "2592", "arg2_id": "2580", "normalized": [] }, { "id": "2660", "type": "CID", "arg1_id": "2592", "arg2_id": "2581", "normalized": [] }, { "id": "2661", "type": "CID", "arg1_id": "2592", "arg2_id": "2582", "normalized": [] }, { "id": "2662", "type": "CID", "arg1_id": "2592", "arg2_id": "2584", "normalized": [] }, { "id": "2663", "type": "CID", "arg1_id": "2592", "arg2_id": "2585", "normalized": [] }, { "id": "2664", "type": "CID", "arg1_id": "2592", "arg2_id": "2586", "normalized": [] }, { "id": "2665", "type": "CID", "arg1_id": "2592", "arg2_id": "2587", "normalized": [] }, { "id": "2666", "type": "CID", "arg1_id": "2592", "arg2_id": "2588", "normalized": [] }, { "id": "2667", "type": "CID", "arg1_id": "2592", "arg2_id": "2589", "normalized": [] }, { "id": "2668", "type": "CID", "arg1_id": "2592", "arg2_id": "2590", "normalized": [] }, { "id": "2669", "type": "CID", "arg1_id": "2592", "arg2_id": "2596", "normalized": [] }, { "id": "2670", "type": "CID", "arg1_id": "2592", "arg2_id": "2597", "normalized": [] }, { "id": "2671", "type": "CID", "arg1_id": "2592", "arg2_id": "2599", "normalized": [] }, { "id": "2672", "type": "CID", "arg1_id": "2592", "arg2_id": "2600", "normalized": [] }, { "id": "2673", "type": "CID", "arg1_id": "2592", "arg2_id": "2601", "normalized": [] }, { "id": "2674", "type": "CID", "arg1_id": "2592", "arg2_id": "2602", "normalized": [] }, { "id": "2675", "type": "CID", "arg1_id": "2592", "arg2_id": "2605", "normalized": [] }, { "id": "2676", "type": "CID", "arg1_id": "2606", "arg2_id": "2580", "normalized": [] }, { "id": "2677", "type": "CID", "arg1_id": "2606", "arg2_id": "2581", "normalized": [] }, { "id": "2678", "type": "CID", "arg1_id": "2606", "arg2_id": "2582", "normalized": [] }, { "id": "2679", "type": "CID", "arg1_id": "2606", "arg2_id": "2584", "normalized": [] }, { "id": "2680", "type": "CID", "arg1_id": "2606", "arg2_id": "2585", "normalized": [] }, { "id": "2681", "type": "CID", "arg1_id": "2606", "arg2_id": "2586", "normalized": [] }, { "id": "2682", "type": "CID", "arg1_id": "2606", "arg2_id": "2587", "normalized": [] }, { "id": "2683", "type": "CID", "arg1_id": "2606", "arg2_id": "2588", "normalized": [] }, { "id": "2684", "type": "CID", "arg1_id": "2606", "arg2_id": "2589", "normalized": [] }, { "id": "2685", "type": "CID", "arg1_id": "2606", "arg2_id": "2590", "normalized": [] }, { "id": "2686", "type": "CID", "arg1_id": "2606", "arg2_id": "2596", "normalized": [] }, { "id": "2687", "type": "CID", "arg1_id": "2606", "arg2_id": "2597", "normalized": [] }, { "id": "2688", "type": "CID", "arg1_id": "2606", "arg2_id": "2599", "normalized": [] }, { "id": "2689", "type": "CID", "arg1_id": "2606", "arg2_id": "2600", "normalized": [] }, { "id": "2690", "type": "CID", "arg1_id": "2606", "arg2_id": "2601", "normalized": [] }, { "id": "2691", "type": "CID", "arg1_id": "2606", "arg2_id": "2602", "normalized": [] }, { "id": "2692", "type": "CID", "arg1_id": "2606", "arg2_id": "2605", "normalized": [] }, { "id": "2693", "type": "CID", "arg1_id": "2593", "arg2_id": "2580", "normalized": [] }, { "id": "2694", "type": "CID", "arg1_id": "2593", "arg2_id": "2581", "normalized": [] }, { "id": "2695", "type": "CID", "arg1_id": "2593", "arg2_id": "2582", "normalized": [] }, { "id": "2696", "type": "CID", "arg1_id": "2593", "arg2_id": "2584", "normalized": [] }, { "id": "2697", "type": "CID", "arg1_id": "2593", "arg2_id": "2585", "normalized": [] }, { "id": "2698", "type": "CID", "arg1_id": "2593", "arg2_id": "2586", "normalized": [] }, { "id": "2699", "type": "CID", "arg1_id": "2593", "arg2_id": "2587", "normalized": [] }, { "id": "2700", "type": "CID", "arg1_id": "2593", "arg2_id": "2588", "normalized": [] }, { "id": "2701", "type": "CID", "arg1_id": "2593", "arg2_id": "2589", "normalized": [] }, { "id": "2702", "type": "CID", "arg1_id": "2593", "arg2_id": "2590", "normalized": [] }, { "id": "2703", "type": "CID", "arg1_id": "2593", "arg2_id": "2596", "normalized": [] }, { "id": "2704", "type": "CID", "arg1_id": "2593", "arg2_id": "2597", "normalized": [] }, { "id": "2705", "type": "CID", "arg1_id": "2593", "arg2_id": "2599", "normalized": [] }, { "id": "2706", "type": "CID", "arg1_id": "2593", "arg2_id": "2600", "normalized": [] }, { "id": "2707", "type": "CID", "arg1_id": "2593", "arg2_id": "2601", "normalized": [] }, { "id": "2708", "type": "CID", "arg1_id": "2593", "arg2_id": "2602", "normalized": [] }, { "id": "2709", "type": "CID", "arg1_id": "2593", "arg2_id": "2605", "normalized": [] }, { "id": "2710", "type": "CID", "arg1_id": "2594", "arg2_id": "2580", "normalized": [] }, { "id": "2711", "type": "CID", "arg1_id": "2594", "arg2_id": "2581", "normalized": [] }, { "id": "2712", "type": "CID", "arg1_id": "2594", "arg2_id": "2582", "normalized": [] }, { "id": "2713", "type": "CID", "arg1_id": "2594", "arg2_id": "2584", "normalized": [] }, { "id": "2714", "type": "CID", "arg1_id": "2594", "arg2_id": "2585", "normalized": [] }, { "id": "2715", "type": "CID", "arg1_id": "2594", "arg2_id": "2586", "normalized": [] }, { "id": "2716", "type": "CID", "arg1_id": "2594", "arg2_id": "2587", "normalized": [] }, { "id": "2717", "type": "CID", "arg1_id": "2594", "arg2_id": "2588", "normalized": [] }, { "id": "2718", "type": "CID", "arg1_id": "2594", "arg2_id": "2589", "normalized": [] }, { "id": "2719", "type": "CID", "arg1_id": "2594", "arg2_id": "2590", "normalized": [] }, { "id": "2720", "type": "CID", "arg1_id": "2594", "arg2_id": "2596", "normalized": [] }, { "id": "2721", "type": "CID", "arg1_id": "2594", "arg2_id": "2597", "normalized": [] }, { "id": "2722", "type": "CID", "arg1_id": "2594", "arg2_id": "2599", "normalized": [] }, { "id": "2723", "type": "CID", "arg1_id": "2594", "arg2_id": "2600", "normalized": [] }, { "id": "2724", "type": "CID", "arg1_id": "2594", "arg2_id": "2601", "normalized": [] }, { "id": "2725", "type": "CID", "arg1_id": "2594", "arg2_id": "2602", "normalized": [] }, { "id": "2726", "type": "CID", "arg1_id": "2594", "arg2_id": "2605", "normalized": [] }, { "id": "2727", "type": "CID", "arg1_id": "2598", "arg2_id": "2580", "normalized": [] }, { "id": "2728", "type": "CID", "arg1_id": "2598", "arg2_id": "2581", "normalized": [] }, { "id": "2729", "type": "CID", "arg1_id": "2598", "arg2_id": "2582", "normalized": [] }, { "id": "2730", "type": "CID", "arg1_id": "2598", "arg2_id": "2584", "normalized": [] }, { "id": "2731", "type": "CID", "arg1_id": "2598", "arg2_id": "2585", "normalized": [] }, { "id": "2732", "type": "CID", "arg1_id": "2598", "arg2_id": "2586", "normalized": [] }, { "id": "2733", "type": "CID", "arg1_id": "2598", "arg2_id": "2587", "normalized": [] }, { "id": "2734", "type": "CID", "arg1_id": "2598", "arg2_id": "2588", "normalized": [] }, { "id": "2735", "type": "CID", "arg1_id": "2598", "arg2_id": "2589", "normalized": [] }, { "id": "2736", "type": "CID", "arg1_id": "2598", "arg2_id": "2590", "normalized": [] }, { "id": "2737", "type": "CID", "arg1_id": "2598", "arg2_id": "2596", "normalized": [] }, { "id": "2738", "type": "CID", "arg1_id": "2598", "arg2_id": "2597", "normalized": [] }, { "id": "2739", "type": "CID", "arg1_id": "2598", "arg2_id": "2599", "normalized": [] }, { "id": "2740", "type": "CID", "arg1_id": "2598", "arg2_id": "2600", "normalized": [] }, { "id": "2741", "type": "CID", "arg1_id": "2598", "arg2_id": "2601", "normalized": [] }, { "id": "2742", "type": "CID", "arg1_id": "2598", "arg2_id": "2602", "normalized": [] }, { "id": "2743", "type": "CID", "arg1_id": "2598", "arg2_id": "2605", "normalized": [] } ]

[ { "id": "2745", "type": "title", "text": [ "Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products." ], "offsets": [ [ 0, 83 ] ] }, { "id": "2746", "type": "abstract", "text": [ "We describe a 25-year-old woman with pre-existing mitral valve prolapse who developed intractable ventricular fibrillation after consuming a \"natural energy\" guarana health drink containing a high concentration of caffeine. This case highlights the need for adequate labelling and regulation of such products." ], "offsets": [ [ 84, 393 ] ] } ]

[ { "id": "2747", "type": "Chemical", "text": [ "Caffeine" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002110" } ] }, { "id": "2748", "type": "Disease", "text": [ "cardiac arrhythmia" ], "offsets": [ [ 17, 35 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001145" } ] }, { "id": "2749", "type": "Disease", "text": [ "mitral valve prolapse" ], "offsets": [ [ 134, 155 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008945" } ] }, { "id": "2750", "type": "Disease", "text": [ "ventricular fibrillation" ], "offsets": [ [ 182, 206 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014693" } ] }, { "id": "2751", "type": "Chemical", "text": [ "caffeine" ], "offsets": [ [ 298, 306 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002110" } ] } ]

[]

[]

[ { "id": "2752", "type": "CID", "arg1_id": "2747", "arg2_id": "2750", "normalized": [] }, { "id": "2753", "type": "CID", "arg1_id": "2751", "arg2_id": "2750", "normalized": [] } ]

[ { "id": "2755", "type": "title", "text": [ "Bladder retention of urine as a result of continuous intravenous infusion of fentanyl: 2 case reports." ], "offsets": [ [ 0, 102 ] ] }, { "id": "2756", "type": "abstract", "text": [ "Sedation has been commonly used in the neonate to decrease the stress and pain from the noxious stimuli and invasive procedures in the neonatal intensive care unit, as well as to facilitate synchrony between ventilator and spontaneous breaths. Fentanyl, an opioid analgesic, is frequently used in the neonatal intensive care unit setting for these very purposes. Various reported side effects of fentanyl administration include chest wall rigidity, hypotension, respiratory depression, and bradycardia. Here, 2 cases of urinary bladder retention leading to renal pelvocalyceal dilatation mimicking hydronephrosis as a result of continuous infusion of fentanyl are reported." ], "offsets": [ [ 103, 776 ] ] } ]

[ { "id": "2757", "type": "Disease", "text": [ "retention of urine" ], "offsets": [ [ 8, 26 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016055" } ] }, { "id": "2758", "type": "Chemical", "text": [ "fentanyl" ], "offsets": [ [ 77, 85 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005283" } ] }, { "id": "2759", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 177, 181 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010146" } ] }, { "id": "2760", "type": "Chemical", "text": [ "Fentanyl" ], "offsets": [ [ 347, 355 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005283" } ] }, { "id": "2761", "type": "Chemical", "text": [ "fentanyl" ], "offsets": [ [ 499, 507 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005283" } ] }, { "id": "2762", "type": "Disease", "text": [ "chest wall rigidity" ], "offsets": [ [ 531, 550 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009127" } ] }, { "id": "2763", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 552, 563 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "2764", "type": "Disease", "text": [ "respiratory depression" ], "offsets": [ [ 565, 587 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012131" } ] }, { "id": "2765", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 593, 604 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "2766", "type": "Disease", "text": [ "urinary bladder retention" ], "offsets": [ [ 623, 648 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001745" } ] }, { "id": "2767", "type": "Disease", "text": [ "hydronephrosis" ], "offsets": [ [ 701, 715 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006869" } ] }, { "id": "2768", "type": "Chemical", "text": [ "fentanyl" ], "offsets": [ [ 754, 762 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005283" } ] } ]

[]

[]

[ { "id": "2769", "type": "CID", "arg1_id": "2758", "arg2_id": "2764", "normalized": [] }, { "id": "2770", "type": "CID", "arg1_id": "2760", "arg2_id": "2764", "normalized": [] }, { "id": "2771", "type": "CID", "arg1_id": "2761", "arg2_id": "2764", "normalized": [] }, { "id": "2772", "type": "CID", "arg1_id": "2768", "arg2_id": "2764", "normalized": [] }, { "id": "2773", "type": "CID", "arg1_id": "2758", "arg2_id": "2763", "normalized": [] }, { "id": "2774", "type": "CID", "arg1_id": "2760", "arg2_id": "2763", "normalized": [] }, { "id": "2775", "type": "CID", "arg1_id": "2761", "arg2_id": "2763", "normalized": [] }, { "id": "2776", "type": "CID", "arg1_id": "2768", "arg2_id": "2763", "normalized": [] }, { "id": "2777", "type": "CID", "arg1_id": "2758", "arg2_id": "2766", "normalized": [] }, { "id": "2778", "type": "CID", "arg1_id": "2760", "arg2_id": "2766", "normalized": [] }, { "id": "2779", "type": "CID", "arg1_id": "2761", "arg2_id": "2766", "normalized": [] }, { "id": "2780", "type": "CID", "arg1_id": "2768", "arg2_id": "2766", "normalized": [] }, { "id": "2781", "type": "CID", "arg1_id": "2758", "arg2_id": "2765", "normalized": [] }, { "id": "2782", "type": "CID", "arg1_id": "2760", "arg2_id": "2765", "normalized": [] }, { "id": "2783", "type": "CID", "arg1_id": "2761", "arg2_id": "2765", "normalized": [] }, { "id": "2784", "type": "CID", "arg1_id": "2768", "arg2_id": "2765", "normalized": [] }, { "id": "2785", "type": "CID", "arg1_id": "2758", "arg2_id": "2757", "normalized": [] }, { "id": "2786", "type": "CID", "arg1_id": "2760", "arg2_id": "2757", "normalized": [] }, { "id": "2787", "type": "CID", "arg1_id": "2761", "arg2_id": "2757", "normalized": [] }, { "id": "2788", "type": "CID", "arg1_id": "2768", "arg2_id": "2757", "normalized": [] } ]

[ { "id": "2790", "type": "title", "text": [ "Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice." ], "offsets": [ [ 0, 106 ] ] }, { "id": "2791", "type": "abstract", "text": [ "Highly active antiretroviral therapy (HAART) is implicated in cardiomyopathy (CM) and in elevated plasma lactate (LA) in AIDS through mechanisms of mitochondrial dysfunction. To determine mitochondrial events from HAART in vivo, 8-week-old hemizygous transgenic AIDS mice (NL4-3Delta gag/pol; TG) and wild-type FVB/n littermates were treated with the HAART combination of zidovudine, lamivudine, and indinavir or vehicle control for 10 days or 35 days. At termination of the experiments, mice underwent echocardiography, quantitation of abundance of molecular markers of CM (ventricular mRNA encoding atrial natriuretic factor [ANF] and sarcoplasmic calcium ATPase [SERCA2]), and determination of plasma LA. Myocardial histologic features were analyzed semiquantitatively and results were confirmed by transmission electron microscopy. After 35 days in the TG + HAART cohort, left ventricular mass increased 160% by echocardiography. Molecularly, ANF mRNA increased 250% and SERCA2 mRNA decreased 57%. Biochemically, LA was elevated (8.5 +/- 2.0 mM). Pathologically, granular cytoplasmic changes were found in cardiac myocytes, indicating enlarged, damaged mitochondria. Findings were confirmed ultrastructurally. No changes were found in other cohorts. After 10 days, only ANF was elevated, and only in the TG + HAART cohort. Results show that cumulative HAART caused mitochondrial CM with elevated LA in AIDS transgenic mice." ], "offsets": [ [ 107, 1534 ] ] } ]

[ { "id": "2792", "type": "Disease", "text": [ "cardiomyopathy" ], "offsets": [ [ 39, 53 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009202" } ] }, { "id": "2793", "type": "Chemical", "text": [ "lactate" ], "offsets": [ [ 74, 81 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019344" } ] }, { "id": "2794", "type": "Disease", "text": [ "AIDS" ], "offsets": [ [ 96, 100 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000163" } ] }, { "id": "2795", "type": "Disease", "text": [ "cardiomyopathy" ], "offsets": [ [ 169, 183 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009202" } ] }, { "id": "2796", "type": "Disease", "text": [ "CM" ], "offsets": [ [ 185, 187 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009202" } ] }, { "id": "2797", "type": "Chemical", "text": [ "lactate" ], "offsets": [ [ 212, 219 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019344" } ] }, { "id": "2798", "type": "Chemical", "text": [ "LA" ], "offsets": [ [ 221, 223 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019344" } ] }, { "id": "2799", "type": "Disease", "text": [ "AIDS" ], "offsets": [ [ 228, 232 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000163" } ] }, { "id": "2800", "type": "Disease", "text": [ "mitochondrial dysfunction" ], "offsets": [ [ 255, 280 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D028361" } ] }, { "id": "2801", "type": "Disease", "text": [ "AIDS" ], "offsets": [ [ 369, 373 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000163" } ] }, { "id": "2802", "type": "Chemical", "text": [ "zidovudine" ], "offsets": [ [ 479, 489 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015215" } ] }, { "id": "2803", "type": "Chemical", "text": [ "lamivudine" ], "offsets": [ [ 491, 501 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019259" } ] }, { "id": "2804", "type": "Chemical", "text": [ "indinavir" ], "offsets": [ [ 507, 516 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019469" } ] }, { "id": "2805", "type": "Disease", "text": [ "CM" ], "offsets": [ [ 678, 680 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009202" } ] }, { "id": "2806", "type": "Chemical", "text": [ "calcium" ], "offsets": [ [ 757, 764 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002118" } ] }, { "id": "2807", "type": "Chemical", "text": [ "LA" ], "offsets": [ [ 811, 813 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019344" } ] }, { "id": "2808", "type": "Chemical", "text": [ "LA" ], "offsets": [ [ 1124, 1126 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019344" } ] }, { "id": "2809", "type": "Disease", "text": [ "CM" ], "offsets": [ [ 1490, 1492 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009202" } ] }, { "id": "2810", "type": "Chemical", "text": [ "LA" ], "offsets": [ [ 1507, 1509 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019344" } ] }, { "id": "2811", "type": "Disease", "text": [ "AIDS" ], "offsets": [ [ 1513, 1517 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000163" } ] } ]

[]

[]

[ { "id": "2812", "type": "CID", "arg1_id": "2804", "arg2_id": "2792", "normalized": [] }, { "id": "2813", "type": "CID", "arg1_id": "2804", "arg2_id": "2795", "normalized": [] }, { "id": "2814", "type": "CID", "arg1_id": "2804", "arg2_id": "2796", "normalized": [] }, { "id": "2815", "type": "CID", "arg1_id": "2804", "arg2_id": "2805", "normalized": [] }, { "id": "2816", "type": "CID", "arg1_id": "2804", "arg2_id": "2809", "normalized": [] }, { "id": "2817", "type": "CID", "arg1_id": "2803", "arg2_id": "2792", "normalized": [] }, { "id": "2818", "type": "CID", "arg1_id": "2803", "arg2_id": "2795", "normalized": [] }, { "id": "2819", "type": "CID", "arg1_id": "2803", "arg2_id": "2796", "normalized": [] }, { "id": "2820", "type": "CID", "arg1_id": "2803", "arg2_id": "2805", "normalized": [] }, { "id": "2821", "type": "CID", "arg1_id": "2803", "arg2_id": "2809", "normalized": [] }, { "id": "2822", "type": "CID", "arg1_id": "2802", "arg2_id": "2792", "normalized": [] }, { "id": "2823", "type": "CID", "arg1_id": "2802", "arg2_id": "2795", "normalized": [] }, { "id": "2824", "type": "CID", "arg1_id": "2802", "arg2_id": "2796", "normalized": [] }, { "id": "2825", "type": "CID", "arg1_id": "2802", "arg2_id": "2805", "normalized": [] }, { "id": "2826", "type": "CID", "arg1_id": "2802", "arg2_id": "2809", "normalized": [] } ]

[ { "id": "2828", "type": "title", "text": [ "Oral contraceptives and the risk of myocardial infarction." ], "offsets": [ [ 0, 58 ] ] }, { "id": "2829", "type": "abstract", "text": [ "BACKGROUND: An association between the use of oral contraceptives and the risk of myocardial infarction has been found in some, but not all, studies. We investigated this association, according to the type of progestagen included in third-generation (i.e., desogestrel or gestodene) and second-generation (i.e., levonorgestrel) oral contraceptives, the dose of estrogen, and the presence or absence of prothrombotic mutations METHODS: In a nationwide, population-based, case-control study, we identified and enrolled 248 women 18 through 49 years of age who had had a first myocardial infarction between 1990 and 1995 and 925 control women who had not had a myocardial infarction and who were matched for age, calendar year of the index event, and area of residence. Subjects supplied information on oral-contraceptive use and major cardiovascular risk factors. An analysis for factor V Leiden and the G20210A mutation in the prothrombin gene was conducted in 217 patients and 763 controls RESULTS: The odds ratio for myocardial infarction among women who used any type of combined oral contraceptive, as compared with nonusers, was 2.0 (95 percent confidence interval, 1.5 to 2.8). The adjusted odds ratio was 2.5 (95 percent confidence interval, 1.5 to 4.1) among women who used second-generation oral contraceptives and 1.3 (95 percent confidence interval, 0.7 to 2.5) among those who used third-generation oral contraceptives. Among women who used oral contraceptives, the odds ratio was 2.1 (95 percent confidence interval, 1.5 to 3.0) for those without a prothrombotic mutation and 1.9 (95 percent confidence interval, 0.6 to 5.5) for those with a mutation CONCLUSIONS: The risk of myocardial infarction was increased among women who used second-generation oral contraceptives. The results with respect to the use of third-generation oral contraceptives were inconclusive but suggested that the risk was lower than the risk associated with second-generation oral contraceptives. The risk of myocardial infarction was similar among women who used oral contraceptives whether or not they had a prothrombotic mutation." ], "offsets": [ [ 59, 2180 ] ] } ]

[ { "id": "2830", "type": "Chemical", "text": [ "Oral contraceptives" ], "offsets": [ [ 0, 19 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2831", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 36, 57 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "2832", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 105, 124 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2833", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 141, 162 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "2834", "type": "Chemical", "text": [ "progestagen" ], "offsets": [ [ 268, 279 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011372" } ] }, { "id": "2835", "type": "Chemical", "text": [ "desogestrel" ], "offsets": [ [ 316, 327 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017135" } ] }, { "id": "2836", "type": "Chemical", "text": [ "gestodene" ], "offsets": [ [ 331, 340 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C033273" } ] }, { "id": "2837", "type": "Chemical", "text": [ "levonorgestrel" ], "offsets": [ [ 371, 385 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016912" } ] }, { "id": "2838", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 387, 406 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2839", "type": "Chemical", "text": [ "estrogen" ], "offsets": [ [ 420, 428 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004967" } ] }, { "id": "2840", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 633, 654 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "2841", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 717, 738 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "2842", "type": "Chemical", "text": [ "oral-contraceptive" ], "offsets": [ [ 859, 877 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2843", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 1077, 1098 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "2844", "type": "Chemical", "text": [ "oral contraceptive" ], "offsets": [ [ 1141, 1159 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2845", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 1358, 1377 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2846", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 1469, 1488 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2847", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 1511, 1530 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2848", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 1747, 1768 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "2849", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 1822, 1841 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2850", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 1899, 1918 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2851", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 2023, 2042 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] }, { "id": "2852", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 2056, 2077 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "2853", "type": "Chemical", "text": [ "oral contraceptives" ], "offsets": [ [ 2111, 2130 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003276" } ] } ]

[]

[]

[ { "id": "2854", "type": "CID", "arg1_id": "2830", "arg2_id": "2831", "normalized": [] }, { "id": "2855", "type": "CID", "arg1_id": "2830", "arg2_id": "2833", "normalized": [] }, { "id": "2856", "type": "CID", "arg1_id": "2830", "arg2_id": "2840", "normalized": [] }, { "id": "2857", "type": "CID", "arg1_id": "2830", "arg2_id": "2841", "normalized": [] }, { "id": "2858", "type": "CID", "arg1_id": "2830", "arg2_id": "2843", "normalized": [] }, { "id": "2859", "type": "CID", "arg1_id": "2830", "arg2_id": "2848", "normalized": [] }, { "id": "2860", "type": "CID", "arg1_id": "2830", "arg2_id": "2852", "normalized": [] }, { "id": "2861", "type": "CID", "arg1_id": "2832", "arg2_id": "2831", "normalized": [] }, { "id": "2862", "type": "CID", "arg1_id": "2832", "arg2_id": "2833", "normalized": [] }, { "id": "2863", "type": "CID", "arg1_id": "2832", "arg2_id": "2840", "normalized": [] }, { "id": "2864", "type": "CID", "arg1_id": "2832", "arg2_id": "2841", "normalized": [] }, { "id": "2865", "type": "CID", "arg1_id": "2832", "arg2_id": "2843", "normalized": [] }, { "id": "2866", "type": "CID", "arg1_id": "2832", "arg2_id": "2848", "normalized": [] }, { "id": "2867", "type": "CID", "arg1_id": "2832", "arg2_id": "2852", "normalized": [] }, { "id": "2868", "type": "CID", "arg1_id": "2838", "arg2_id": "2831", "normalized": [] }, { "id": "2869", "type": "CID", "arg1_id": "2838", "arg2_id": "2833", "normalized": [] }, { "id": "2870", "type": "CID", "arg1_id": "2838", "arg2_id": "2840", "normalized": [] }, { "id": "2871", "type": "CID", "arg1_id": "2838", "arg2_id": "2841", "normalized": [] }, { "id": "2872", "type": "CID", "arg1_id": "2838", "arg2_id": "2843", "normalized": [] }, { "id": "2873", "type": "CID", "arg1_id": "2838", "arg2_id": "2848", "normalized": [] }, { "id": "2874", "type": "CID", "arg1_id": "2838", "arg2_id": "2852", "normalized": [] }, { "id": "2875", "type": "CID", "arg1_id": "2842", "arg2_id": "2831", "normalized": [] }, { "id": "2876", "type": "CID", "arg1_id": "2842", "arg2_id": "2833", "normalized": [] }, { "id": "2877", "type": "CID", "arg1_id": "2842", "arg2_id": "2840", "normalized": [] }, { "id": "2878", "type": "CID", "arg1_id": "2842", "arg2_id": "2841", "normalized": [] }, { "id": "2879", "type": "CID", "arg1_id": "2842", "arg2_id": "2843", "normalized": [] }, { "id": "2880", "type": "CID", "arg1_id": "2842", "arg2_id": "2848", "normalized": [] }, { "id": "2881", "type": "CID", "arg1_id": "2842", "arg2_id": "2852", "normalized": [] }, { "id": "2882", "type": "CID", "arg1_id": "2844", "arg2_id": "2831", "normalized": [] }, { "id": "2883", "type": "CID", "arg1_id": "2844", "arg2_id": "2833", "normalized": [] }, { "id": "2884", "type": "CID", "arg1_id": "2844", "arg2_id": "2840", "normalized": [] }, { "id": "2885", "type": "CID", "arg1_id": "2844", "arg2_id": "2841", "normalized": [] }, { "id": "2886", "type": "CID", "arg1_id": "2844", "arg2_id": "2843", "normalized": [] }, { "id": "2887", "type": "CID", "arg1_id": "2844", "arg2_id": "2848", "normalized": [] }, { "id": "2888", "type": "CID", "arg1_id": "2844", "arg2_id": "2852", "normalized": [] }, { "id": "2889", "type": "CID", "arg1_id": "2845", "arg2_id": "2831", "normalized": [] }, { "id": "2890", "type": "CID", "arg1_id": "2845", "arg2_id": "2833", "normalized": [] }, { "id": "2891", "type": "CID", "arg1_id": "2845", "arg2_id": "2840", "normalized": [] }, { "id": "2892", "type": "CID", "arg1_id": "2845", "arg2_id": "2841", "normalized": [] }, { "id": "2893", "type": "CID", "arg1_id": "2845", "arg2_id": "2843", "normalized": [] }, { "id": "2894", "type": "CID", "arg1_id": "2845", "arg2_id": "2848", "normalized": [] }, { "id": "2895", "type": "CID", "arg1_id": "2845", "arg2_id": "2852", "normalized": [] }, { "id": "2896", "type": "CID", "arg1_id": "2846", "arg2_id": "2831", "normalized": [] }, { "id": "2897", "type": "CID", "arg1_id": "2846", "arg2_id": "2833", "normalized": [] }, { "id": "2898", "type": "CID", "arg1_id": "2846", "arg2_id": "2840", "normalized": [] }, { "id": "2899", "type": "CID", "arg1_id": "2846", "arg2_id": "2841", "normalized": [] }, { "id": "2900", "type": "CID", "arg1_id": "2846", "arg2_id": "2843", "normalized": [] }, { "id": "2901", "type": "CID", "arg1_id": "2846", "arg2_id": "2848", "normalized": [] }, { "id": "2902", "type": "CID", "arg1_id": "2846", "arg2_id": "2852", "normalized": [] }, { "id": "2903", "type": "CID", "arg1_id": "2847", "arg2_id": "2831", "normalized": [] }, { "id": "2904", "type": "CID", "arg1_id": "2847", "arg2_id": "2833", "normalized": [] }, { "id": "2905", "type": "CID", "arg1_id": "2847", "arg2_id": "2840", "normalized": [] }, { "id": "2906", "type": "CID", "arg1_id": "2847", "arg2_id": "2841", "normalized": [] }, { "id": "2907", "type": "CID", "arg1_id": "2847", "arg2_id": "2843", "normalized": [] }, { "id": "2908", "type": "CID", "arg1_id": "2847", "arg2_id": "2848", "normalized": [] }, { "id": "2909", "type": "CID", "arg1_id": "2847", "arg2_id": "2852", "normalized": [] }, { "id": "2910", "type": "CID", "arg1_id": "2849", "arg2_id": "2831", "normalized": [] }, { "id": "2911", "type": "CID", "arg1_id": "2849", "arg2_id": "2833", "normalized": [] }, { "id": "2912", "type": "CID", "arg1_id": "2849", "arg2_id": "2840", "normalized": [] }, { "id": "2913", "type": "CID", "arg1_id": "2849", "arg2_id": "2841", "normalized": [] }, { "id": "2914", "type": "CID", "arg1_id": "2849", "arg2_id": "2843", "normalized": [] }, { "id": "2915", "type": "CID", "arg1_id": "2849", "arg2_id": "2848", "normalized": [] }, { "id": "2916", "type": "CID", "arg1_id": "2849", "arg2_id": "2852", "normalized": [] }, { "id": "2917", "type": "CID", "arg1_id": "2850", "arg2_id": "2831", "normalized": [] }, { "id": "2918", "type": "CID", "arg1_id": "2850", "arg2_id": "2833", "normalized": [] }, { "id": "2919", "type": "CID", "arg1_id": "2850", "arg2_id": "2840", "normalized": [] }, { "id": "2920", "type": "CID", "arg1_id": "2850", "arg2_id": "2841", "normalized": [] }, { "id": "2921", "type": "CID", "arg1_id": "2850", "arg2_id": "2843", "normalized": [] }, { "id": "2922", "type": "CID", "arg1_id": "2850", "arg2_id": "2848", "normalized": [] }, { "id": "2923", "type": "CID", "arg1_id": "2850", "arg2_id": "2852", "normalized": [] }, { "id": "2924", "type": "CID", "arg1_id": "2851", "arg2_id": "2831", "normalized": [] }, { "id": "2925", "type": "CID", "arg1_id": "2851", "arg2_id": "2833", "normalized": [] }, { "id": "2926", "type": "CID", "arg1_id": "2851", "arg2_id": "2840", "normalized": [] }, { "id": "2927", "type": "CID", "arg1_id": "2851", "arg2_id": "2841", "normalized": [] }, { "id": "2928", "type": "CID", "arg1_id": "2851", "arg2_id": "2843", "normalized": [] }, { "id": "2929", "type": "CID", "arg1_id": "2851", "arg2_id": "2848", "normalized": [] }, { "id": "2930", "type": "CID", "arg1_id": "2851", "arg2_id": "2852", "normalized": [] }, { "id": "2931", "type": "CID", "arg1_id": "2853", "arg2_id": "2831", "normalized": [] }, { "id": "2932", "type": "CID", "arg1_id": "2853", "arg2_id": "2833", "normalized": [] }, { "id": "2933", "type": "CID", "arg1_id": "2853", "arg2_id": "2840", "normalized": [] }, { "id": "2934", "type": "CID", "arg1_id": "2853", "arg2_id": "2841", "normalized": [] }, { "id": "2935", "type": "CID", "arg1_id": "2853", "arg2_id": "2843", "normalized": [] }, { "id": "2936", "type": "CID", "arg1_id": "2853", "arg2_id": "2848", "normalized": [] }, { "id": "2937", "type": "CID", "arg1_id": "2853", "arg2_id": "2852", "normalized": [] } ]

[ { "id": "2939", "type": "title", "text": [ "Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats." ], "offsets": [ [ 0, 136 ] ] }, { "id": "2940", "type": "abstract", "text": [ "The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted bilaterally with cannulae into the accumbens shell or core, and then were locally injected with GR 55562 (an antagonist of 5-HT1B receptors) or CP 93129 (an agonist of 5-HT1B receptors). Given alone to any accumbal subregion, GR 55562 (0.1-10 microg/side) or CP 93129 (0.1-10 microg/side) did not change basal locomotor activity. Systemic cocaine (10 mg/kg) significantly increased the locomotor activity of rats. GR 55562 (0.1-10 microg/side), administered intra-accumbens shell prior to cocaine, dose-dependently attenuated the psychostimulant-induced locomotor hyperactivity. Such attenuation was not found in animals which had been injected with GR 55562 into the accumbens core. When injected into the accumbens shell (but not the core) before cocaine, CP 93129 (0.1-10 microg/side) enhanced the locomotor response to cocaine; the maximum effect being observed after 10 microg/side of the agonist. The later enhancement was attenuated after intra-accumbens shell treatment with GR 55562 (1 microg/side). Our findings indicate that cocaine induced hyperlocomotion is modified by 5-HT1B receptor ligands microinjected into the accumbens shell, but not core, this modification consisting in inhibitory and facilitatory effects of the 5-HT1B receptor antagonist (GR 55562) and agonist (CP 93129), respectively. In other words, the present results suggest that the accumbal shell 5-HT1B receptors play a permissive role in the behavioural response to the psychostimulant." ], "offsets": [ [ 137, 1863 ] ] } ]

[ { "id": "2941", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 88, 95 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "2942", "type": "Disease", "text": [ "locomotor hyperactivity" ], "offsets": [ [ 104, 127 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009069" } ] }, { "id": "2943", "type": "Disease", "text": [ "locomotor hyperactivity" ], "offsets": [ [ 308, 331 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009069" } ] }, { "id": "2944", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 343, 350 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "2945", "type": "Chemical", "text": [ "GR 55562" ], "offsets": [ [ 488, 496 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C103477" } ] }, { "id": "2946", "type": "Chemical", "text": [ "CP 93129" ], "offsets": [ [ 536, 544 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C065046" } ] }, { "id": "2947", "type": "Chemical", "text": [ "GR 55562" ], "offsets": [ [ 618, 626 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C103477" } ] }, { "id": "2948", "type": "Chemical", "text": [ "CP 93129" ], "offsets": [ [ 651, 659 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C065046" } ] }, { "id": "2949", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 731, 738 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "2950", "type": "Chemical", "text": [ "GR 55562" ], "offsets": [ [ 806, 814 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C103477" } ] }, { "id": "2951", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 881, 888 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "2952", "type": "Disease", "text": [ "locomotor hyperactivity" ], "offsets": [ [ 946, 969 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009069" } ] }, { "id": "2953", "type": "Chemical", "text": [ "GR 55562" ], "offsets": [ [ 1042, 1050 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C103477" } ] }, { "id": "2954", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 1141, 1148 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "2955", "type": "Chemical", "text": [ "CP 93129" ], "offsets": [ [ 1150, 1158 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C065046" } ] }, { "id": "2956", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 1215, 1222 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "2957", "type": "Chemical", "text": [ "GR 55562" ], "offsets": [ [ 1375, 1383 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C103477" } ] }, { "id": "2958", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 1428, 1435 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "2959", "type": "Disease", "text": [ "hyperlocomotion" ], "offsets": [ [ 1444, 1459 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009069" } ] }, { "id": "2960", "type": "Chemical", "text": [ "GR 55562" ], "offsets": [ [ 1656, 1664 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C103477" } ] }, { "id": "2961", "type": "Chemical", "text": [ "CP 93129" ], "offsets": [ [ 1679, 1687 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C065046" } ] } ]

[]

[]

[ { "id": "2962", "type": "CID", "arg1_id": "2941", "arg2_id": "2942", "normalized": [] }, { "id": "2963", "type": "CID", "arg1_id": "2941", "arg2_id": "2943", "normalized": [] }, { "id": "2964", "type": "CID", "arg1_id": "2941", "arg2_id": "2952", "normalized": [] }, { "id": "2965", "type": "CID", "arg1_id": "2941", "arg2_id": "2959", "normalized": [] }, { "id": "2966", "type": "CID", "arg1_id": "2944", "arg2_id": "2942", "normalized": [] }, { "id": "2967", "type": "CID", "arg1_id": "2944", "arg2_id": "2943", "normalized": [] }, { "id": "2968", "type": "CID", "arg1_id": "2944", "arg2_id": "2952", "normalized": [] }, { "id": "2969", "type": "CID", "arg1_id": "2944", "arg2_id": "2959", "normalized": [] }, { "id": "2970", "type": "CID", "arg1_id": "2949", "arg2_id": "2942", "normalized": [] }, { "id": "2971", "type": "CID", "arg1_id": "2949", "arg2_id": "2943", "normalized": [] }, { "id": "2972", "type": "CID", "arg1_id": "2949", "arg2_id": "2952", "normalized": [] }, { "id": "2973", "type": "CID", "arg1_id": "2949", "arg2_id": "2959", "normalized": [] }, { "id": "2974", "type": "CID", "arg1_id": "2951", "arg2_id": "2942", "normalized": [] }, { "id": "2975", "type": "CID", "arg1_id": "2951", "arg2_id": "2943", "normalized": [] }, { "id": "2976", "type": "CID", "arg1_id": "2951", "arg2_id": "2952", "normalized": [] }, { "id": "2977", "type": "CID", "arg1_id": "2951", "arg2_id": "2959", "normalized": [] }, { "id": "2978", "type": "CID", "arg1_id": "2954", "arg2_id": "2942", "normalized": [] }, { "id": "2979", "type": "CID", "arg1_id": "2954", "arg2_id": "2943", "normalized": [] }, { "id": "2980", "type": "CID", "arg1_id": "2954", "arg2_id": "2952", "normalized": [] }, { "id": "2981", "type": "CID", "arg1_id": "2954", "arg2_id": "2959", "normalized": [] }, { "id": "2982", "type": "CID", "arg1_id": "2956", "arg2_id": "2942", "normalized": [] }, { "id": "2983", "type": "CID", "arg1_id": "2956", "arg2_id": "2943", "normalized": [] }, { "id": "2984", "type": "CID", "arg1_id": "2956", "arg2_id": "2952", "normalized": [] }, { "id": "2985", "type": "CID", "arg1_id": "2956", "arg2_id": "2959", "normalized": [] }, { "id": "2986", "type": "CID", "arg1_id": "2958", "arg2_id": "2942", "normalized": [] }, { "id": "2987", "type": "CID", "arg1_id": "2958", "arg2_id": "2943", "normalized": [] }, { "id": "2988", "type": "CID", "arg1_id": "2958", "arg2_id": "2952", "normalized": [] }, { "id": "2989", "type": "CID", "arg1_id": "2958", "arg2_id": "2959", "normalized": [] }, { "id": "2990", "type": "CID", "arg1_id": "2946", "arg2_id": "2942", "normalized": [] }, { "id": "2991", "type": "CID", "arg1_id": "2946", "arg2_id": "2943", "normalized": [] }, { "id": "2992", "type": "CID", "arg1_id": "2946", "arg2_id": "2952", "normalized": [] }, { "id": "2993", "type": "CID", "arg1_id": "2946", "arg2_id": "2959", "normalized": [] }, { "id": "2994", "type": "CID", "arg1_id": "2948", "arg2_id": "2942", "normalized": [] }, { "id": "2995", "type": "CID", "arg1_id": "2948", "arg2_id": "2943", "normalized": [] }, { "id": "2996", "type": "CID", "arg1_id": "2948", "arg2_id": "2952", "normalized": [] }, { "id": "2997", "type": "CID", "arg1_id": "2948", "arg2_id": "2959", "normalized": [] }, { "id": "2998", "type": "CID", "arg1_id": "2955", "arg2_id": "2942", "normalized": [] }, { "id": "2999", "type": "CID", "arg1_id": "2955", "arg2_id": "2943", "normalized": [] }, { "id": "3000", "type": "CID", "arg1_id": "2955", "arg2_id": "2952", "normalized": [] }, { "id": "3001", "type": "CID", "arg1_id": "2955", "arg2_id": "2959", "normalized": [] }, { "id": "3002", "type": "CID", "arg1_id": "2961", "arg2_id": "2942", "normalized": [] }, { "id": "3003", "type": "CID", "arg1_id": "2961", "arg2_id": "2943", "normalized": [] }, { "id": "3004", "type": "CID", "arg1_id": "2961", "arg2_id": "2952", "normalized": [] }, { "id": "3005", "type": "CID", "arg1_id": "2961", "arg2_id": "2959", "normalized": [] } ]

[ { "id": "3007", "type": "title", "text": [ "Ticlopidine-induced cholestatic hepatitis." ], "offsets": [ [ 0, 42 ] ] }, { "id": "3008", "type": "abstract", "text": [ "OBJECTIVE: To report 2 cases of ticlopidine-induced cholestatic hepatitis, investigate its mechanism, and compare the observed main characteristics with those of the published cases. CASE SUMMARIES: Two patients developed prolonged cholestatic hepatitis after receiving ticlopidine following percutaneous coronary angioplasty, with complete remission during the follow-up period. T-cell stimulation by therapeutic concentration of ticlopidine was demonstrated in vitro in the patients, but not in healthy controls. DISCUSSION: Cholestatic hepatitis is a rare complication of the antiplatelet agent ticlopidine; several cases have been reported but few in the English literature. Our patients developed jaundice following treatment with ticlopidine and showed the clinical and laboratory characteristics of cholestatic hepatitis, which resolved after discontinuation of the drug. Hepatitis may develop weeks after discontinuation of the drug and may run a prolonged course, but complete remission was observed in all reported cases. An objective causality assessment revealed that the adverse drug event was probably related to the use of ticlopidine. The mechanisms of this ticlopidine-induced cholestasis are unclear. Immune mechanisms may be involved in the drug's hepatotoxicity, as suggested by the T-cell stimulation study reported here. CONCLUSIONS: Cholestatic hepatitis is a rare adverse effect of ticlopidine that may be immune mediated. Patients receiving the drug should be monitored with liver function tests along with complete blood cell counts. This complication will be observed even less often in the future as ticlopidine is being replaced by the newer antiplatelet agent clopidogrel." ], "offsets": [ [ 43, 1745 ] ] } ]

[ { "id": "3009", "type": "Chemical", "text": [ "Ticlopidine" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3010", "type": "Disease", "text": [ "cholestatic hepatitis" ], "offsets": [ [ 20, 41 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" }, { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3011", "type": "Disease", "text": [ "cholestatic" ], "offsets": [ [ 20, 31 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" } ] }, { "id": "3012", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 32, 41 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3013", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 75, 86 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3014", "type": "Disease", "text": [ "cholestatic hepatitis" ], "offsets": [ [ 95, 116 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" }, { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3015", "type": "Disease", "text": [ "cholestatic" ], "offsets": [ [ 95, 106 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" } ] }, { "id": "3016", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 107, 116 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3017", "type": "Disease", "text": [ "cholestatic hepatitis" ], "offsets": [ [ 275, 296 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" }, { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3018", "type": "Disease", "text": [ "cholestatic" ], "offsets": [ [ 275, 286 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" } ] }, { "id": "3019", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 287, 296 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3020", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 313, 324 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3021", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 474, 485 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3022", "type": "Disease", "text": [ "Cholestatic hepatitis" ], "offsets": [ [ 570, 591 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" }, { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3023", "type": "Disease", "text": [ "Cholestatic" ], "offsets": [ [ 570, 581 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" } ] }, { "id": "3024", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 582, 591 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3025", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 641, 652 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3026", "type": "Disease", "text": [ "jaundice" ], "offsets": [ [ 745, 753 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007565" } ] }, { "id": "3027", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 779, 790 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3028", "type": "Disease", "text": [ "cholestatic hepatitis" ], "offsets": [ [ 849, 870 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" }, { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3029", "type": "Disease", "text": [ "cholestatic" ], "offsets": [ [ 849, 860 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" } ] }, { "id": "3030", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 861, 870 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3031", "type": "Disease", "text": [ "Hepatitis" ], "offsets": [ [ 922, 931 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3032", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 1181, 1192 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3033", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 1217, 1228 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3034", "type": "Disease", "text": [ "cholestasis" ], "offsets": [ [ 1237, 1248 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" } ] }, { "id": "3035", "type": "Disease", "text": [ "hepatotoxicity" ], "offsets": [ [ 1310, 1324 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3036", "type": "Disease", "text": [ "Cholestatic hepatitis" ], "offsets": [ [ 1399, 1420 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" }, { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3037", "type": "Disease", "text": [ "Cholestatic" ], "offsets": [ [ 1399, 1410 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002779" } ] }, { "id": "3038", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 1411, 1420 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "3039", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 1449, 1460 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3040", "type": "Chemical", "text": [ "ticlopidine" ], "offsets": [ [ 1671, 1682 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013988" } ] }, { "id": "3041", "type": "Chemical", "text": [ "clopidogrel" ], "offsets": [ [ 1733, 1744 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C055162" } ] } ]

[]

[]

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[ { "id": "3323", "type": "title", "text": [ "Epithelial sodium channel (ENaC) subunit mRNA and protein expression in rats with puromycin aminonucleoside-induced nephrotic syndrome." ], "offsets": [ [ 0, 135 ] ] }, { "id": "3324", "type": "abstract", "text": [ "In experimental nephrotic syndrome, urinary sodium excretion is decreased during the early phase of the disease. The molecular mechanism(s) leading to salt retention has not been completely elucidated. The rate-limiting constituent of collecting duct sodium transport is the epithelial sodium channel (ENaC). We examined the abundance of ENaC subunit mRNAs and proteins in puromycin aminonucleoside (PAN)-induced nephrotic syndrome. The time courses of urinary sodium excretion, plasma aldosterone concentration and proteinuria were studied in male Sprague-Dawley rats treated with a single dose of either PAN or vehicle. The relative amounts of alphaENaC, betaENaC and gammaENaC mRNAs were determined in kidneys from these rats by real-time quantitative TaqMan PCR, and the amounts of proteins by Western blot. The kinetics of urinary sodium excretion and the appearance of proteinuria were comparable with those reported previously. Sodium retention occurred on days 2, 3 and 6 after PAN injection. A significant up-regulation of alphaENaC and betaENaC mRNA abundance on days 1 and 2 preceded sodium retention on days 2 and 3. Conversely, down-regulation of alphaENaC, betaENaC and gammaENaC mRNA expression on day 3 occurred in the presence of high aldosterone concentrations, and was followed by a return of sodium excretion to control values. The amounts of alphaENaC, betaENaC and gammaENaC proteins were not increased during PAN-induced sodium retention. In conclusion, ENaC mRNA expression, especially alphaENaC, is increased in the very early phase of the experimental model of PAN-induced nephrotic syndrome in rats, but appears to escape from the regulation by aldosterone after day 3." ], "offsets": [ [ 136, 1832 ] ] } ]

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[]

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[ { "id": "3351", "type": "CID", "arg1_id": "3326", "arg2_id": "3337", "normalized": [] }, { "id": "3352", "type": "CID", "arg1_id": "3326", "arg2_id": "3340", "normalized": [] }, { "id": "3353", "type": "CID", "arg1_id": "3332", "arg2_id": "3337", "normalized": [] }, { "id": "3354", "type": "CID", "arg1_id": "3332", "arg2_id": "3340", "normalized": [] }, { "id": "3355", "type": "CID", "arg1_id": "3333", "arg2_id": "3337", "normalized": [] }, { "id": "3356", "type": "CID", "arg1_id": "3333", "arg2_id": "3340", "normalized": [] }, { "id": "3357", "type": "CID", "arg1_id": "3338", "arg2_id": "3337", "normalized": [] }, { "id": "3358", "type": "CID", "arg1_id": "3338", "arg2_id": "3340", "normalized": [] }, { "id": "3359", "type": "CID", "arg1_id": "3342", "arg2_id": "3337", "normalized": [] }, { "id": "3360", "type": "CID", "arg1_id": "3342", "arg2_id": "3340", "normalized": [] }, { "id": "3361", "type": "CID", "arg1_id": "3346", "arg2_id": "3337", "normalized": [] }, { "id": "3362", "type": "CID", "arg1_id": "3346", "arg2_id": "3340", "normalized": [] }, { "id": "3363", "type": "CID", "arg1_id": "3348", "arg2_id": "3337", "normalized": [] }, { "id": "3364", "type": "CID", "arg1_id": "3348", "arg2_id": "3340", "normalized": [] }, { "id": "3365", "type": "CID", "arg1_id": "3326", "arg2_id": "3327", "normalized": [] }, { "id": "3366", "type": "CID", "arg1_id": "3326", "arg2_id": "3328", "normalized": [] }, { "id": "3367", "type": "CID", "arg1_id": "3326", "arg2_id": "3334", "normalized": [] }, { "id": "3368", "type": "CID", "arg1_id": "3326", "arg2_id": "3349", "normalized": [] }, { "id": "3369", "type": "CID", "arg1_id": "3332", "arg2_id": "3327", "normalized": [] }, { "id": "3370", "type": "CID", "arg1_id": "3332", "arg2_id": "3328", "normalized": [] }, { "id": "3371", "type": "CID", "arg1_id": "3332", "arg2_id": "3334", "normalized": [] }, { "id": "3372", "type": "CID", "arg1_id": "3332", "arg2_id": "3349", "normalized": [] }, { "id": "3373", "type": "CID", "arg1_id": "3333", "arg2_id": "3327", "normalized": [] }, { "id": "3374", "type": "CID", "arg1_id": "3333", "arg2_id": "3328", "normalized": [] }, { "id": "3375", "type": "CID", "arg1_id": "3333", "arg2_id": "3334", "normalized": [] }, { "id": "3376", "type": "CID", "arg1_id": "3333", "arg2_id": "3349", "normalized": [] }, { "id": "3377", "type": "CID", "arg1_id": "3338", "arg2_id": "3327", "normalized": [] }, { "id": "3378", "type": "CID", "arg1_id": "3338", "arg2_id": "3328", "normalized": [] }, { "id": "3379", "type": "CID", "arg1_id": "3338", "arg2_id": "3334", "normalized": [] }, { "id": "3380", "type": "CID", "arg1_id": "3338", "arg2_id": "3349", "normalized": [] }, { "id": "3381", "type": "CID", "arg1_id": "3342", "arg2_id": "3327", "normalized": [] }, { "id": "3382", "type": "CID", "arg1_id": "3342", "arg2_id": "3328", "normalized": [] }, { "id": "3383", "type": "CID", "arg1_id": "3342", "arg2_id": "3334", "normalized": [] }, { "id": "3384", "type": "CID", "arg1_id": "3342", "arg2_id": "3349", "normalized": [] }, { "id": "3385", "type": "CID", "arg1_id": "3346", "arg2_id": "3327", "normalized": [] }, { "id": "3386", "type": "CID", "arg1_id": "3346", "arg2_id": "3328", "normalized": [] }, { "id": "3387", "type": "CID", "arg1_id": "3346", "arg2_id": "3334", "normalized": [] }, { "id": "3388", "type": "CID", "arg1_id": "3346", "arg2_id": "3349", "normalized": [] }, { "id": "3389", "type": "CID", "arg1_id": "3348", "arg2_id": "3327", "normalized": [] }, { "id": "3390", "type": "CID", "arg1_id": "3348", "arg2_id": "3328", "normalized": [] }, { "id": "3391", "type": "CID", "arg1_id": "3348", "arg2_id": "3334", "normalized": [] }, { "id": "3392", "type": "CID", "arg1_id": "3348", "arg2_id": "3349", "normalized": [] } ]

[ { "id": "3394", "type": "title", "text": [ "NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release." ], "offsets": [ [ 0, 164 ] ] }, { "id": "3395", "type": "abstract", "text": [ "The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura) and eight controls participated in the study. Sublingual nitroglycerin (0.5 mg) was administered. Blood was collected from the antecubital vein four times: 60 min before and after the nitroglycerin application, and 60 and 120 min after the beginning of the migraine attack (mean 344 and 404 min; 12 subjects). In those subjects who had no migraine attack (11 subjects) a similar time schedule was used. Plasma CGRP concentration increased significantly (P<0.01) during the migraine attack and returned to baseline after the cessation of the migraine. In addition, both change and peak, showed significant positive correlations with migraine headache intensity (P<0.001). However, plasma CGRP concentrations failed to change during immediate headache and in the subjects with no migraine attack. Basal CGRP concentration was significantly higher and platelet 5-HT content tended to be lower in subjects who experienced a migraine attack. Platelet serotonin content decreased significantly (P<0.01) after nitroglycerin in subjects with no migraine attack but no consistent change was observed in patients with migraine attack. In conclusion, the fact that plasma CGRP concentration correlates with the timing and severity of a migraine headache suggests a direct relationship between CGRP and migraine. In contrast, serotonin release from platelets does not provoke migraine, it may even counteract the headache and the concomitant CGRP release in this model." ], "offsets": [ [ 165, 1943 ] ] } ]

[ { "id": "3396", "type": "Chemical", "text": [ "NO" ], "offsets": [ [ 0, 2 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009569" } ] }, { "id": "3397", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 11, 19 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3398", "type": "Chemical", "text": [ "calcitonin gene-related peptide" ], "offsets": [ [ 54, 85 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3399", "type": "Chemical", "text": [ "CGRP" ], "offsets": [ [ 87, 91 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3400", "type": "Chemical", "text": [ "serotonin" ], "offsets": [ [ 146, 155 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012701" } ] }, { "id": "3401", "type": "Chemical", "text": [ "calcitonin gene-related peptide" ], "offsets": [ [ 235, 266 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3402", "type": "Chemical", "text": [ "CGRP" ], "offsets": [ [ 268, 272 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3403", "type": "Chemical", "text": [ "serotonin" ], "offsets": [ [ 301, 310 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012701" } ] }, { "id": "3404", "type": "Chemical", "text": [ "5-hydroxytriptamine" ], "offsets": [ [ 312, 331 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012701" } ] }, { "id": "3405", "type": "Chemical", "text": [ "5-HT" ], "offsets": [ [ 333, 337 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012701" } ] }, { "id": "3406", "type": "Disease", "text": [ "headache" ], "offsets": [ [ 368, 376 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006261" } ] }, { "id": "3407", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 401, 409 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3408", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 429, 442 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "3409", "type": "Disease", "text": [ "migraineurs (without aura)" ], "offsets": [ [ 459, 485 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020326" } ] }, { "id": "3410", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 543, 556 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "3411", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 670, 683 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "3412", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 743, 751 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3413", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 825, 833 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3414", "type": "Chemical", "text": [ "CGRP" ], "offsets": [ [ 896, 900 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3415", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 959, 967 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3416", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1027, 1035 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3417", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1118, 1126 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3418", "type": "Disease", "text": [ "headache" ], "offsets": [ [ 1127, 1135 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006261" } ] }, { "id": "3419", "type": "Chemical", "text": [ "CGRP" ], "offsets": [ [ 1173, 1177 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3420", "type": "Disease", "text": [ "headache" ], "offsets": [ [ 1227, 1235 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006261" } ] }, { "id": "3421", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1264, 1272 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3422", "type": "Chemical", "text": [ "CGRP" ], "offsets": [ [ 1287, 1291 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3423", "type": "Chemical", "text": [ "5-HT" ], "offsets": [ [ 1344, 1348 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012701" } ] }, { "id": "3424", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1406, 1414 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3425", "type": "Chemical", "text": [ "serotonin" ], "offsets": [ [ 1432, 1441 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012701" } ] }, { "id": "3426", "type": "Chemical", "text": [ "nitroglycerin" ], "offsets": [ [ 1489, 1502 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005996" } ] }, { "id": "3427", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1523, 1531 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3428", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1594, 1602 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3429", "type": "Chemical", "text": [ "CGRP" ], "offsets": [ [ 1647, 1651 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3430", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1711, 1719 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3431", "type": "Disease", "text": [ "headache" ], "offsets": [ [ 1720, 1728 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006261" } ] }, { "id": "3432", "type": "Chemical", "text": [ "CGRP" ], "offsets": [ [ 1768, 1772 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] }, { "id": "3433", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1777, 1785 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3434", "type": "Chemical", "text": [ "serotonin" ], "offsets": [ [ 1800, 1809 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012701" } ] }, { "id": "3435", "type": "Disease", "text": [ "migraine" ], "offsets": [ [ 1850, 1858 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008881" } ] }, { "id": "3436", "type": "Disease", "text": [ "headache" ], "offsets": [ [ 1887, 1895 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006261" } ] }, { "id": "3437", "type": "Chemical", "text": [ "CGRP" ], "offsets": [ [ 1916, 1920 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015740" } ] } ]

[]

[]

[ { "id": "3438", "type": "CID", "arg1_id": "3408", "arg2_id": "3409", "normalized": [] }, { "id": "3439", "type": "CID", "arg1_id": "3410", "arg2_id": "3409", "normalized": [] }, { "id": "3440", "type": "CID", "arg1_id": "3411", "arg2_id": "3409", "normalized": [] }, { "id": "3441", "type": "CID", "arg1_id": "3426", "arg2_id": "3409", "normalized": [] }, { "id": "3442", "type": "CID", "arg1_id": "3396", "arg2_id": "3409", "normalized": [] } ]

[ { "id": "3444", "type": "title", "text": [ "Coronary aneurysm after implantation of a paclitaxel-eluting stent." ], "offsets": [ [ 0, 67 ] ] }, { "id": "3445", "type": "abstract", "text": [ "Formation of coronary aneurysm is a rare complication of stenting with bare metal stents, but based on experimental studies drug-eluting stents may induce toxic effects on the vessel wall with incomplete stent apposition, aneurysm formation and with the potential of stent thrombosis or vessel rupture. We present a 43-year-old man who developed a coronary aneurysm in the right coronary artery 6 months after receiving a paclitaxel-eluting stent. The patient was asymptomatic and the aneurysm was detected in a routine control. Angiography and intracoronary ultrasound demonstrated lack of contact between stent and vessel wall in a 15-mm long segment with maximal aneurysm diameter of 6.0 mm. The patient was successfully treated with a graft stent." ], "offsets": [ [ 68, 819 ] ] } ]

[ { "id": "3446", "type": "Disease", "text": [ "Coronary aneurysm" ], "offsets": [ [ 0, 17 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003323" } ] }, { "id": "3447", "type": "Chemical", "text": [ "paclitaxel" ], "offsets": [ [ 42, 52 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017239" } ] }, { "id": "3448", "type": "Disease", "text": [ "coronary aneurysm" ], "offsets": [ [ 81, 98 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003323" } ] }, { "id": "3449", "type": "Disease", "text": [ "aneurysm" ], "offsets": [ [ 290, 298 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000783" } ] }, { "id": "3450", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 341, 351 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3451", "type": "Disease", "text": [ "vessel rupture" ], "offsets": [ [ 355, 369 ] ], "normalized": [] }, { "id": "3452", "type": "Disease", "text": [ "coronary aneurysm" ], "offsets": [ [ 416, 433 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003323" } ] }, { "id": "3453", "type": "Chemical", "text": [ "paclitaxel" ], "offsets": [ [ 490, 500 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017239" } ] }, { "id": "3454", "type": "Disease", "text": [ "aneurysm" ], "offsets": [ [ 553, 561 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000783" } ] }, { "id": "3455", "type": "Disease", "text": [ "aneurysm" ], "offsets": [ [ 734, 742 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000783" } ] } ]

[]

[]

[ { "id": "3456", "type": "CID", "arg1_id": "3447", "arg2_id": "3446", "normalized": [] }, { "id": "3457", "type": "CID", "arg1_id": "3447", "arg2_id": "3448", "normalized": [] }, { "id": "3458", "type": "CID", "arg1_id": "3447", "arg2_id": "3452", "normalized": [] }, { "id": "3459", "type": "CID", "arg1_id": "3453", "arg2_id": "3446", "normalized": [] }, { "id": "3460", "type": "CID", "arg1_id": "3453", "arg2_id": "3448", "normalized": [] }, { "id": "3461", "type": "CID", "arg1_id": "3453", "arg2_id": "3452", "normalized": [] } ]

[ { "id": "3463", "type": "title", "text": [ "Behavioral effects of urotensin-II centrally administered in mice." ], "offsets": [ [ 0, 66 ] ] }, { "id": "3464", "type": "abstract", "text": [ "Urotensin-II (U-II) receptors are widely distributed in the central nervous system. Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. However, the behavioral effects of centrally administered U-II have received little attention. In the present study, we tested the effects of i.c.v. injections of U-II on behavioral, metabolic, and endocrine responses in mice. Administration of graded doses of U-II (1-10,000 ng/mouse) provoked: (1) a dose-dependent reduction in the number of head dips in the hole-board test; (2) a dose-dependent reduction in the number of entries in the white chamber in the black-and-white compartment test, and in the number of entries in the central platform and open arms in the plus-maze test; and (3) a dose-dependent increase in the duration of immobility in the forced-swimming test and tail suspension test. Intracerebroventricular injection of U-II also caused an increase in: food intake at doses of 100 and 1,000 ng/mouse, water intake at doses of 100-10,000 ng/mouse, and horizontal locomotion activity at a dose of 10,000 ng/mouse. Whatever was the dose, the central administration of U-II had no effect on body temperature, nociception, apomorphine-induced penile erection and climbing behavior, and stress-induced plasma corticosterone level. Taken together, the present study demonstrates that the central injection of U-II at doses of 1-10,000 ng/mouse induces anxiogenic- and depressant-like effects in mouse. These data suggest that U-II may be involved in some aspects of psychiatric disorders." ], "offsets": [ [ 67, 1692 ] ] } ]

[ { "id": "3465", "type": "Chemical", "text": [ "urotensin-II" ], "offsets": [ [ 22, 34 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3466", "type": "Chemical", "text": [ "Urotensin-II" ], "offsets": [ [ 67, 79 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3467", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 81, 85 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3468", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 197, 201 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3469", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 209, 221 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "3470", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 226, 237 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "3471", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 348, 352 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3472", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 453, 457 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3473", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 551, 555 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3474", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 1031, 1035 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3475", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 1276, 1280 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3476", "type": "Chemical", "text": [ "apomorphine" ], "offsets": [ [ 1329, 1340 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001058" } ] }, { "id": "3477", "type": "Disease", "text": [ "penile erection" ], "offsets": [ [ 1349, 1364 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010409" } ] }, { "id": "3478", "type": "Chemical", "text": [ "corticosterone" ], "offsets": [ [ 1414, 1428 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003345" } ] }, { "id": "3479", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 1513, 1517 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3480", "type": "Chemical", "text": [ "U-II" ], "offsets": [ [ 1630, 1634 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014579" } ] }, { "id": "3481", "type": "Disease", "text": [ "psychiatric disorders" ], "offsets": [ [ 1670, 1691 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001523" } ] } ]

[]

[]

[ { "id": "3482", "type": "CID", "arg1_id": "3476", "arg2_id": "3477", "normalized": [] } ]

[ { "id": "3484", "type": "title", "text": [ "Recurrent dysphonia and acitretin." ], "offsets": [ [ 0, 34 ] ] }, { "id": "3485", "type": "abstract", "text": [ "We report the case of a woman complaining of dysphonia while she was treated by acitretin. Her symptoms totally regressed after drug withdrawal and reappeared when acitretin was reintroduced. To our knowledge, this is the first case of acitretin-induced dysphonia. This effect may be related to the pharmacological effect of this drug on mucous membranes." ], "offsets": [ [ 35, 390 ] ] } ]

[ { "id": "3486", "type": "Disease", "text": [ "dysphonia" ], "offsets": [ [ 10, 19 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D055154" } ] }, { "id": "3487", "type": "Chemical", "text": [ "acitretin" ], "offsets": [ [ 24, 33 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017255" } ] }, { "id": "3488", "type": "Disease", "text": [ "dysphonia" ], "offsets": [ [ 80, 89 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D055154" } ] }, { "id": "3489", "type": "Chemical", "text": [ "acitretin" ], "offsets": [ [ 115, 124 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017255" } ] }, { "id": "3490", "type": "Chemical", "text": [ "acitretin" ], "offsets": [ [ 199, 208 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017255" } ] }, { "id": "3491", "type": "Chemical", "text": [ "acitretin" ], "offsets": [ [ 271, 280 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017255" } ] }, { "id": "3492", "type": "Disease", "text": [ "dysphonia" ], "offsets": [ [ 289, 298 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D055154" } ] } ]

[]

[]

[ { "id": "3493", "type": "CID", "arg1_id": "3487", "arg2_id": "3486", "normalized": [] }, { "id": "3494", "type": "CID", "arg1_id": "3487", "arg2_id": "3488", "normalized": [] }, { "id": "3495", "type": "CID", "arg1_id": "3487", "arg2_id": "3492", "normalized": [] }, { "id": "3496", "type": "CID", "arg1_id": "3489", "arg2_id": "3486", "normalized": [] }, { "id": "3497", "type": "CID", "arg1_id": "3489", "arg2_id": "3488", "normalized": [] }, { "id": "3498", "type": "CID", "arg1_id": "3489", "arg2_id": "3492", "normalized": [] }, { "id": "3499", "type": "CID", "arg1_id": "3490", "arg2_id": "3486", "normalized": [] }, { "id": "3500", "type": "CID", "arg1_id": "3490", "arg2_id": "3488", "normalized": [] }, { "id": "3501", "type": "CID", "arg1_id": "3490", "arg2_id": "3492", "normalized": [] }, { "id": "3502", "type": "CID", "arg1_id": "3491", "arg2_id": "3486", "normalized": [] }, { "id": "3503", "type": "CID", "arg1_id": "3491", "arg2_id": "3488", "normalized": [] }, { "id": "3504", "type": "CID", "arg1_id": "3491", "arg2_id": "3492", "normalized": [] } ]

[ { "id": "3506", "type": "title", "text": [ "Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans." ], "offsets": [ [ 0, 115 ] ] }, { "id": "3507", "type": "abstract", "text": [ "Abnormal processing of somatosensory inputs in the central nervous system (central sensitization) is the mechanism accounting for the enhanced pain sensitivity in the skin surrounding tissue injury (secondary hyperalgesia). Secondary hyperalgesia shares clinical characteristics with neurogenic hyperalgesia in patients with neuropathic pain. Abnormal brain responses to somatosensory stimuli have been found in patients with hyperalgesia as well as in normal subjects during experimental central sensitization. The aim of this study was to assess the effects of gabapentin, a drug effective in neuropathic pain patients, on brain processing of nociceptive information in normal and central sensitization states. Using functional magnetic resonance imaging (fMRI) in normal volunteers, we studied the gabapentin-induced modulation of brain activity in response to nociceptive mechanical stimulation of normal skin and capsaicin-induced secondary hyperalgesia. The dose of gabapentin was 1,800 mg per os, in a single administration. We found that (i) gabapentin reduced the activations in the bilateral operculoinsular cortex, independently of the presence of central sensitization; (ii) gabapentin reduced the activation in the brainstem, only during central sensitization; (iii) gabapentin suppressed stimulus-induced deactivations, only during central sensitization; this effect was more robust than the effect on brain activation. The observed drug-induced effects were not due to changes in the baseline fMRI signal. These findings indicate that gabapentin has a measurable antinociceptive effect and a stronger antihyperalgesic effect most evident in the brain areas undergoing deactivation, thus supporting the concept that gabapentin is more effective in modulating nociceptive transmission when central sensitization is present." ], "offsets": [ [ 116, 1952 ] ] } ]

[ { "id": "3508", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 30, 34 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010146" } ] }, { "id": "3509", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 259, 263 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010146" } ] }, { "id": "3510", "type": "Disease", "text": [ "tissue injury" ], "offsets": [ [ 300, 313 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017695" } ] }, { "id": "3511", "type": "Disease", "text": [ "secondary hyperalgesia" ], "offsets": [ [ 315, 337 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006930" } ] }, { "id": "3512", "type": "Disease", "text": [ "Secondary hyperalgesia" ], "offsets": [ [ 340, 362 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006930" } ] }, { "id": "3513", "type": "Disease", "text": [ "neurogenic hyperalgesia" ], "offsets": [ [ 400, 423 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006930" } ] }, { "id": "3514", "type": "Disease", "text": [ "neuropathic pain" ], "offsets": [ [ 441, 457 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009437" } ] }, { "id": "3515", "type": "Disease", "text": [ "hyperalgesia" ], "offsets": [ [ 542, 554 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006930" } ] }, { "id": "3516", "type": "Chemical", "text": [ "gabapentin" ], "offsets": [ [ 679, 689 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C040029" } ] }, { "id": "3517", "type": "Disease", "text": [ "neuropathic pain" ], "offsets": [ [ 711, 727 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009437" } ] }, { "id": "3518", "type": "Chemical", "text": [ "gabapentin" ], "offsets": [ [ 917, 927 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C040029" } ] }, { "id": "3519", "type": "Chemical", "text": [ "capsaicin" ], "offsets": [ [ 1034, 1043 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002211" } ] }, { "id": "3520", "type": "Disease", "text": [ "secondary hyperalgesia" ], "offsets": [ [ 1052, 1074 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006930" } ] }, { "id": "3521", "type": "Chemical", "text": [ "gabapentin" ], "offsets": [ [ 1088, 1098 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C040029" } ] }, { "id": "3522", "type": "Chemical", "text": [ "gabapentin" ], "offsets": [ [ 1166, 1176 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C040029" } ] }, { "id": "3523", "type": "Chemical", "text": [ "gabapentin" ], "offsets": [ [ 1303, 1313 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C040029" } ] }, { "id": "3524", "type": "Chemical", "text": [ "gabapentin" ], "offsets": [ [ 1396, 1406 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C040029" } ] }, { "id": "3525", "type": "Chemical", "text": [ "gabapentin" ], "offsets": [ [ 1666, 1676 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C040029" } ] }, { "id": "3526", "type": "Chemical", "text": [ "gabapentin" ], "offsets": [ [ 1846, 1856 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C040029" } ] } ]

[]

[]

[ { "id": "3527", "type": "CID", "arg1_id": "3519", "arg2_id": "3511", "normalized": [] }, { "id": "3528", "type": "CID", "arg1_id": "3519", "arg2_id": "3512", "normalized": [] }, { "id": "3529", "type": "CID", "arg1_id": "3519", "arg2_id": "3513", "normalized": [] }, { "id": "3530", "type": "CID", "arg1_id": "3519", "arg2_id": "3515", "normalized": [] }, { "id": "3531", "type": "CID", "arg1_id": "3519", "arg2_id": "3520", "normalized": [] } ]

[ { "id": "3533", "type": "title", "text": [ "MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgement processes." ], "offsets": [ [ 0, 135 ] ] }, { "id": "3534", "type": "abstract", "text": [ "In recent years working memory deficits have been reported in users of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). The current study aimed to assess the impact of MDMA use on three separate central executive processes (set shifting, inhibition and memory updating) and also on \"prefrontal\" mediated social and emotional judgement processes. Fifteen polydrug ecstasy users and 15 polydrug non-ecstasy user controls completed a general drug use questionnaire, the Brixton Spatial Anticipation task (set shifting), Backward Digit Span procedure (memory updating), Inhibition of Return (inhibition), an emotional intelligence scale, the Tromso Social Intelligence Scale and the Dysexecutive Questionnaire (DEX). Compared with MDMA-free polydrug controls, MDMA polydrug users showed impairments in set shifting and memory updating, and also in social and emotional judgement processes. The latter two deficits remained significant after controlling for other drug use. These data lend further support to the proposal that cognitive processes mediated by the prefrontal cortex may be impaired by recreational ecstasy use." ], "offsets": [ [ 136, 1258 ] ] } ]

[ { "id": "3535", "type": "Chemical", "text": [ "MDMA" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3536", "type": "Disease", "text": [ "impaired social and emotional judgement processes" ], "offsets": [ [ 85, 134 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003072" } ] }, { "id": "3537", "type": "Disease", "text": [ "memory deficits" ], "offsets": [ [ 160, 175 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "3538", "type": "Chemical", "text": [ "MDMA" ], "offsets": [ [ 207, 211 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3539", "type": "Chemical", "text": [ "3,4-methylenedioxymethamphetamine" ], "offsets": [ [ 213, 246 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3540", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 248, 255 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3541", "type": "Chemical", "text": [ "MDMA" ], "offsets": [ [ 306, 310 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3542", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 501, 508 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3543", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 535, 542 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3544", "type": "Chemical", "text": [ "MDMA" ], "offsets": [ [ 865, 869 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3545", "type": "Chemical", "text": [ "MDMA" ], "offsets": [ [ 894, 898 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "3546", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 1246, 1253 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] } ]

[]

[]

[ { "id": "3547", "type": "CID", "arg1_id": "3535", "arg2_id": "3536", "normalized": [] }, { "id": "3548", "type": "CID", "arg1_id": "3538", "arg2_id": "3536", "normalized": [] }, { "id": "3549", "type": "CID", "arg1_id": "3539", "arg2_id": "3536", "normalized": [] }, { "id": "3550", "type": "CID", "arg1_id": "3540", "arg2_id": "3536", "normalized": [] }, { "id": "3551", "type": "CID", "arg1_id": "3541", "arg2_id": "3536", "normalized": [] }, { "id": "3552", "type": "CID", "arg1_id": "3542", "arg2_id": "3536", "normalized": [] }, { "id": "3553", "type": "CID", "arg1_id": "3543", "arg2_id": "3536", "normalized": [] }, { "id": "3554", "type": "CID", "arg1_id": "3544", "arg2_id": "3536", "normalized": [] }, { "id": "3555", "type": "CID", "arg1_id": "3545", "arg2_id": "3536", "normalized": [] }, { "id": "3556", "type": "CID", "arg1_id": "3546", "arg2_id": "3536", "normalized": [] } ]

[ { "id": "3558", "type": "title", "text": [ "Severe citrate toxicity complicating volunteer apheresis platelet donation." ], "offsets": [ [ 0, 75 ] ] }, { "id": "3559", "type": "abstract", "text": [ "We report a case of severe citrate toxicity during volunteer donor apheresis platelet collection. The donor was a 40-year-old female, first-time apheresis platelet donor. Past medical history was remarkable for hypertension, hyperlipidemia, and depression. Reported medications included bumetanide, pravastatin, and paroxetine. Thirty minutes from the start of the procedure, the donor noted tingling around the mouth, hands, and feet. She then very rapidly developed acute onset of severe facial and extremity tetany. Empirical treatment with intravenous calcium gluconate was initiated, and muscle contractions slowly subsided over approximately 10 to 15 minutes. The events are consistent with a severe reaction to calcium chelation by sodium citrate anticoagulant resulting in symptomatic systemic hypocalcemia. Upon additional retrospective analysis, it was noted that bumetanide is a loop diuretic that may cause significant hypocalcemia. We conclude that careful screening for medications and underlying conditions predisposing to hypocalcemia is recommended to help prevent severe reactions due to citrate toxicity. Laboratory measurement of pre-procedure serum calcium levels in selected donors may identify cases requiring heightened vigilance. The case also illustrates the importance of maintaining preparedness for managing rare but serious reactions in volunteer apheresis blood donors." ], "offsets": [ [ 76, 1476 ] ] } ]

[ { "id": "3560", "type": "Chemical", "text": [ "citrate" ], "offsets": [ [ 7, 14 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C102006" } ] }, { "id": "3561", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 15, 23 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "3562", "type": "Chemical", "text": [ "citrate" ], "offsets": [ [ 103, 110 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C102006" } ] }, { "id": "3563", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 111, 119 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "3564", "type": "Disease", "text": [ "hypertension" ], "offsets": [ [ 287, 299 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "3565", "type": "Disease", "text": [ "hyperlipidemia" ], "offsets": [ [ 301, 315 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006949" } ] }, { "id": "3566", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 321, 331 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "3567", "type": "Chemical", "text": [ "bumetanide" ], "offsets": [ [ 363, 373 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002034" } ] }, { "id": "3568", "type": "Chemical", "text": [ "pravastatin" ], "offsets": [ [ 375, 386 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017035" } ] }, { "id": "3569", "type": "Chemical", "text": [ "paroxetine" ], "offsets": [ [ 392, 402 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017374" } ] }, { "id": "3570", "type": "Disease", "text": [ "tetany" ], "offsets": [ [ 587, 593 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013746" } ] }, { "id": "3571", "type": "Chemical", "text": [ "calcium gluconate" ], "offsets": [ [ 632, 649 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002125" } ] }, { "id": "3572", "type": "Disease", "text": [ "muscle contractions" ], "offsets": [ [ 669, 688 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C536214" } ] }, { "id": "3573", "type": "Chemical", "text": [ "calcium" ], "offsets": [ [ 794, 801 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002118" } ] }, { "id": "3574", "type": "Chemical", "text": [ "sodium citrate" ], "offsets": [ [ 815, 829 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C102006" } ] }, { "id": "3575", "type": "Disease", "text": [ "hypocalcemia" ], "offsets": [ [ 878, 890 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006996" } ] }, { "id": "3576", "type": "Chemical", "text": [ "bumetanide" ], "offsets": [ [ 950, 960 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002034" } ] }, { "id": "3577", "type": "Chemical", "text": [ "loop diuretic" ], "offsets": [ [ 966, 979 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D049994" } ] }, { "id": "3578", "type": "Disease", "text": [ "hypocalcemia" ], "offsets": [ [ 1007, 1019 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006996" } ] }, { "id": "3579", "type": "Disease", "text": [ "hypocalcemia" ], "offsets": [ [ 1114, 1126 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006996" } ] }, { "id": "3580", "type": "Chemical", "text": [ "citrate" ], "offsets": [ [ 1182, 1189 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C102006" } ] }, { "id": "3581", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 1190, 1198 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "3582", "type": "Chemical", "text": [ "calcium" ], "offsets": [ [ 1246, 1253 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002118" } ] } ]

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[ { "id": "3583", "type": "CID", "arg1_id": "3560", "arg2_id": "3575", "normalized": [] }, { "id": "3584", "type": "CID", "arg1_id": "3560", "arg2_id": "3578", "normalized": [] }, { "id": "3585", "type": "CID", "arg1_id": "3560", "arg2_id": "3579", "normalized": [] }, { "id": "3586", "type": "CID", "arg1_id": "3562", "arg2_id": "3575", "normalized": [] }, { "id": "3587", "type": "CID", "arg1_id": "3562", "arg2_id": "3578", "normalized": [] }, { "id": "3588", "type": "CID", "arg1_id": "3562", "arg2_id": "3579", "normalized": [] }, { "id": "3589", "type": "CID", "arg1_id": "3574", "arg2_id": "3575", "normalized": [] }, { "id": "3590", "type": "CID", "arg1_id": "3574", "arg2_id": "3578", "normalized": [] }, { "id": "3591", "type": "CID", "arg1_id": "3574", "arg2_id": "3579", "normalized": [] }, { "id": "3592", "type": "CID", "arg1_id": "3580", "arg2_id": "3575", "normalized": [] }, { "id": "3593", "type": "CID", "arg1_id": "3580", "arg2_id": "3578", "normalized": [] }, { "id": "3594", "type": "CID", "arg1_id": "3580", "arg2_id": "3579", "normalized": [] } ]

[ { "id": "3596", "type": "title", "text": [ "Proteinuria after conversion to sirolimus in renal transplant recipients." ], "offsets": [ [ 0, 73 ] ] }, { "id": "3597", "type": "abstract", "text": [ "Sirolimus (SRL) is a new, potent immunosuppressive agent. More recently, proteinuria has been reported as a consequence of sirolimus therapy, although the mechanism has remained unclear. We retrospectively examined the records of 25 renal transplant patients, who developed or displayed increased proteinuria after SRL conversion. The patient cohort (14 men, 11 women) was treated with SRL as conversion therapy, due to chronic allograft nephropathy (CAN) (n = 15) neoplasia (n = 8); Kaposi's sarcoma, Four skin cancers, One intestinal tumors, One renal cell carsinom) or BK virus nephropathy (n = 2). SRL was started at a mean of 78 +/- 42 (15 to 163) months after transplantation. Mean follow-up on SRL therapy was 20 +/- 12 (6 to 43) months. Proteinuria increased from 0.445 (0 to 1.5) g/d before conversion to 3.2 g/dL (0.2 to 12) after conversion (P = 0.001). Before conversion 8 (32%) patients had no proteinuria, whereas afterwards all patients had proteinuria. In 28% of patients proteinuria remained unchanged, whereas it increased in 68% of patients. In 40% it increased by more than 100%. Twenty-eight percent of patients showed increased proteinuria to the nephrotic range. Biopsies performed in five patients revealed new pathological changes: One membranoproliferative glomerulopathy and interstitial nephritis. These patients showed persistently good graft function. Serum creatinine values did not change significantly: 1.98 +/- 0.8 mg/dL before SRL therapy and 2.53 +/- 1.9 mg/dL at last follow-up (P = .14). Five grafts were lost and the patients returned to dialysis. Five patients displayed CAN and Kaposi's sarcoma. Mean urinary protein of patients who returned to dialysis was 1.26 (0.5 to 3.5) g/d before and 4.7 (3 to 12) g/d after conversion (P = .01). Mean serum creatinine level before conversion was 2.21 mg/dL and thereafter, 4.93 mg/dL (P = .02). Heavy proteinuria was common after the use of SRL as rescue therapy for renal transplantation. Therefore, conversion should be considered for patients who have not developed advanced CAN and proteinuria. The possibility of de novo glomerular pathology under SRL treatment requires further investigation by renal biopsy." ], "offsets": [ [ 74, 2270 ] ] } ]

[ { "id": "3598", "type": "Disease", "text": [ "Proteinuria" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3599", "type": "Chemical", "text": [ "sirolimus" ], "offsets": [ [ 32, 41 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3600", "type": "Chemical", "text": [ "Sirolimus" ], "offsets": [ [ 74, 83 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3601", "type": "Chemical", "text": [ "SRL" ], "offsets": [ [ 85, 88 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3602", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 147, 158 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3603", "type": "Chemical", "text": [ "sirolimus" ], "offsets": [ [ 197, 206 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3604", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 371, 382 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3605", "type": "Chemical", "text": [ "SRL" ], "offsets": [ [ 389, 392 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3606", "type": "Chemical", "text": [ "SRL" ], "offsets": [ [ 460, 463 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3607", "type": "Disease", "text": [ "chronic allograft nephropathy" ], "offsets": [ [ 494, 523 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D051436" } ] }, { "id": "3608", "type": "Disease", "text": [ "CAN" ], "offsets": [ [ 525, 528 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "3609", "type": "Disease", "text": [ "neoplasia" ], "offsets": [ [ 539, 548 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "3610", "type": "Disease", "text": [ "Kaposi's sarcoma" ], "offsets": [ [ 558, 574 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012514" } ] }, { "id": "3611", "type": "Disease", "text": [ "skin cancers" ], "offsets": [ [ 581, 593 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012878" } ] }, { "id": "3612", "type": "Disease", "text": [ "intestinal tumors" ], "offsets": [ [ 599, 616 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007414" } ] }, { "id": "3613", "type": "Disease", "text": [ "renal cell carsinom" ], "offsets": [ [ 622, 641 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002292" } ] }, { "id": "3614", "type": "Disease", "text": [ "nephropathy" ], "offsets": [ [ 655, 666 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "3615", "type": "Chemical", "text": [ "SRL" ], "offsets": [ [ 676, 679 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3616", "type": "Chemical", "text": [ "SRL" ], "offsets": [ [ 775, 778 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3617", "type": "Disease", "text": [ "Proteinuria" ], "offsets": [ [ 819, 830 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3618", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 981, 992 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3619", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 1030, 1041 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3620", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 1062, 1073 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3621", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 1224, 1235 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3622", "type": "Disease", "text": [ "nephrotic" ], "offsets": [ [ 1243, 1252 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009404" } ] }, { "id": "3623", "type": "Disease", "text": [ "membranoproliferative glomerulopathy" ], "offsets": [ [ 1335, 1371 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015433" } ] }, { "id": "3624", "type": "Disease", "text": [ "interstitial nephritis" ], "offsets": [ [ 1376, 1398 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009395" } ] }, { "id": "3625", "type": "Chemical", "text": [ "creatinine" ], "offsets": [ [ 1462, 1472 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003404" } ] }, { "id": "3626", "type": "Chemical", "text": [ "SRL" ], "offsets": [ [ 1536, 1539 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3627", "type": "Disease", "text": [ "CAN" ], "offsets": [ [ 1685, 1688 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "3628", "type": "Disease", "text": [ "Kaposi's sarcoma" ], "offsets": [ [ 1693, 1709 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012514" } ] }, { "id": "3629", "type": "Chemical", "text": [ "creatinine" ], "offsets": [ [ 1863, 1873 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003404" } ] }, { "id": "3630", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 1957, 1968 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3631", "type": "Chemical", "text": [ "SRL" ], "offsets": [ [ 1997, 2000 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] }, { "id": "3632", "type": "Disease", "text": [ "CAN" ], "offsets": [ [ 2134, 2137 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "3633", "type": "Disease", "text": [ "proteinuria" ], "offsets": [ [ 2142, 2153 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011507" } ] }, { "id": "3634", "type": "Chemical", "text": [ "SRL" ], "offsets": [ [ 2209, 2212 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020123" } ] } ]

[]

[]

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"type": "CID", "arg1_id": "3600", "arg2_id": "3602", "normalized": [] }, { "id": "3647", "type": "CID", "arg1_id": "3600", "arg2_id": "3604", "normalized": [] }, { "id": "3648", "type": "CID", "arg1_id": "3600", "arg2_id": "3617", "normalized": [] }, { "id": "3649", "type": "CID", "arg1_id": "3600", "arg2_id": "3618", "normalized": [] }, { "id": "3650", "type": "CID", "arg1_id": "3600", "arg2_id": "3619", "normalized": [] }, { "id": "3651", "type": "CID", "arg1_id": "3600", "arg2_id": "3620", "normalized": [] }, { "id": "3652", "type": "CID", "arg1_id": "3600", "arg2_id": "3621", "normalized": [] }, { "id": "3653", "type": "CID", "arg1_id": "3600", "arg2_id": "3630", "normalized": [] }, { "id": "3654", "type": "CID", "arg1_id": "3600", "arg2_id": "3633", "normalized": [] }, { "id": "3655", "type": "CID", "arg1_id": "3601", "arg2_id": "3598", "normalized": [] }, { "id": "3656", "type": "CID", "arg1_id": "3601", "arg2_id": "3602", "normalized": [] }, { "id": "3657", "type": "CID", "arg1_id": "3601", "arg2_id": "3604", "normalized": [] }, { "id": "3658", "type": "CID", "arg1_id": "3601", "arg2_id": "3617", "normalized": [] }, { "id": "3659", "type": "CID", "arg1_id": "3601", "arg2_id": "3618", "normalized": [] }, { "id": "3660", "type": "CID", "arg1_id": "3601", "arg2_id": "3619", "normalized": [] }, { "id": "3661", "type": "CID", "arg1_id": "3601", "arg2_id": "3620", "normalized": [] }, { "id": "3662", "type": "CID", "arg1_id": "3601", "arg2_id": "3621", "normalized": [] }, { "id": "3663", "type": "CID", "arg1_id": "3601", "arg2_id": "3630", "normalized": [] }, { "id": "3664", "type": "CID", "arg1_id": "3601", "arg2_id": "3633", "normalized": [] }, { "id": "3665", "type": "CID", "arg1_id": "3603", "arg2_id": "3598", "normalized": [] }, { "id": "3666", "type": "CID", "arg1_id": "3603", "arg2_id": "3602", "normalized": [] }, { "id": "3667", "type": "CID", "arg1_id": "3603", "arg2_id": "3604", "normalized": [] }, { "id": "3668", "type": "CID", "arg1_id": "3603", 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"CID", "arg1_id": "3615", "arg2_id": "3621", "normalized": [] }, { "id": "3703", "type": "CID", "arg1_id": "3615", "arg2_id": "3630", "normalized": [] }, { "id": "3704", "type": "CID", "arg1_id": "3615", "arg2_id": "3633", "normalized": [] }, { "id": "3705", "type": "CID", "arg1_id": "3616", "arg2_id": "3598", "normalized": [] }, { "id": "3706", "type": "CID", "arg1_id": "3616", "arg2_id": "3602", "normalized": [] }, { "id": "3707", "type": "CID", "arg1_id": "3616", "arg2_id": "3604", "normalized": [] }, { "id": "3708", "type": "CID", "arg1_id": "3616", "arg2_id": "3617", "normalized": [] }, { "id": "3709", "type": "CID", "arg1_id": "3616", "arg2_id": "3618", "normalized": [] }, { "id": "3710", "type": "CID", "arg1_id": "3616", "arg2_id": "3619", "normalized": [] }, { "id": "3711", "type": "CID", "arg1_id": "3616", "arg2_id": "3620", "normalized": [] }, { "id": "3712", "type": "CID", "arg1_id": "3616", "arg2_id": "3621", "normalized": [] }, { "id": "3713", "type": "CID", "arg1_id": "3616", "arg2_id": "3630", "normalized": [] }, { "id": "3714", "type": "CID", "arg1_id": "3616", "arg2_id": "3633", "normalized": [] }, { "id": "3715", "type": "CID", "arg1_id": "3626", "arg2_id": "3598", "normalized": [] }, { "id": "3716", "type": "CID", "arg1_id": "3626", "arg2_id": "3602", "normalized": [] }, { "id": "3717", "type": "CID", "arg1_id": "3626", "arg2_id": "3604", "normalized": [] }, { "id": "3718", "type": "CID", "arg1_id": "3626", "arg2_id": "3617", "normalized": [] }, { "id": "3719", "type": "CID", "arg1_id": "3626", "arg2_id": "3618", "normalized": [] }, { "id": "3720", "type": "CID", "arg1_id": "3626", "arg2_id": "3619", "normalized": [] }, { "id": "3721", "type": "CID", "arg1_id": "3626", "arg2_id": "3620", "normalized": [] }, { "id": "3722", "type": "CID", "arg1_id": "3626", "arg2_id": "3621", "normalized": [] }, { "id": "3723", "type": "CID", "arg1_id": "3626", "arg2_id": "3630", "normalized": [] }, { "id": "3724", "type": "CID", "arg1_id": "3626", "arg2_id": "3633", "normalized": [] }, { "id": "3725", "type": "CID", "arg1_id": "3631", "arg2_id": "3598", "normalized": [] }, { "id": "3726", "type": "CID", "arg1_id": "3631", "arg2_id": "3602", "normalized": [] }, { "id": "3727", "type": "CID", "arg1_id": "3631", "arg2_id": "3604", "normalized": [] }, { "id": "3728", "type": "CID", "arg1_id": "3631", "arg2_id": "3617", "normalized": [] }, { "id": "3729", "type": "CID", "arg1_id": "3631", "arg2_id": "3618", "normalized": [] }, { "id": "3730", "type": "CID", "arg1_id": "3631", "arg2_id": "3619", "normalized": [] }, { "id": "3731", "type": "CID", "arg1_id": "3631", "arg2_id": "3620", "normalized": [] }, { "id": "3732", "type": "CID", "arg1_id": "3631", "arg2_id": "3621", "normalized": [] }, { "id": "3733", "type": "CID", "arg1_id": "3631", "arg2_id": "3630", "normalized": [] }, { "id": "3734", "type": "CID", "arg1_id": "3631", "arg2_id": "3633", "normalized": [] }, { "id": "3735", "type": "CID", "arg1_id": "3634", "arg2_id": "3598", "normalized": [] }, { "id": "3736", "type": "CID", "arg1_id": "3634", "arg2_id": "3602", "normalized": [] }, { "id": "3737", "type": "CID", "arg1_id": "3634", "arg2_id": "3604", "normalized": [] }, { "id": "3738", "type": "CID", "arg1_id": "3634", "arg2_id": "3617", "normalized": [] }, { "id": "3739", "type": "CID", "arg1_id": "3634", "arg2_id": "3618", "normalized": [] }, { "id": "3740", "type": "CID", "arg1_id": "3634", "arg2_id": "3619", "normalized": [] }, { "id": "3741", "type": "CID", "arg1_id": "3634", "arg2_id": "3620", "normalized": [] }, { "id": "3742", "type": "CID", "arg1_id": "3634", "arg2_id": "3621", "normalized": [] }, { "id": "3743", "type": "CID", "arg1_id": "3634", "arg2_id": "3630", "normalized": [] }, { "id": "3744", "type": "CID", "arg1_id": "3634", "arg2_id": "3633", "normalized": [] } ]

[ { "id": "3746", "type": "title", "text": [ "In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat." ], "offsets": [ [ 0, 119 ] ] }, { "id": "3747", "type": "abstract", "text": [ "In cyclophosphamide-induced cystitis in the rat, detrusor function is impaired and the expression and effects of muscarinic receptors altered. Whether or not the neuronal transmission may be affected by cystitis was presently investigated. Responses of urinary strip preparations from control and cyclophosphamide-pretreated rats to electrical field stimulation and to agonists were assessed in the absence and presence of muscarinic, adrenergic and purinergic receptor antagonists. Generally, atropine reduced contractions, but in contrast to controls, it also reduced responses to low electrical field stimulation intensity (1-5 Hz) in inflamed preparations. In both types, purinoceptor desensitization with alpha,beta-methylene adenosine-5'-triphosphate (alpha,beta-meATP) caused further reductions at low frequencies (<10 Hz). The muscarinic receptor antagonists atropine, 4-diphenylacetoxy-N-methylpiperidine (4-DAMP) ('M(1)/M(3)/M(5)-selective'), methoctramine ('M(2)-selective') and pirenzepine ('M(1)-selective') antagonized the tonic component of the electrical field stimulation-evoked contractile response more potently than the phasic component. 4-DAMP inhibited the tonic contractions in controls more potently than methoctramine and pirenzepine. In inflamed preparations, the muscarinic receptor antagonism on the phasic component of the electrical field stimulation-evoked contraction was decreased and the pirenzepine and 4-DAMP antagonism on the tonic component was much less efficient than in controls. In contrast to controls, methoctramine increased -- instead of decreased -- the tonic responses at high frequencies. While contractions to carbachol and ATP were the same in inflamed and in control strips when related to a reference potassium response, isoprenaline-induced relaxations were smaller in inflamed strips. Thus, in cystitis substantial changes of the efferent functional responses occur. While postjunctional beta-adrenoceptor-mediated relaxations are reduced, effects by prejunctional inhibitory muscarinic receptors may be increased." ], "offsets": [ [ 120, 2189 ] ] } ]

[ { "id": "3748", "type": "Chemical", "text": [ "cyclophosphamide" ], "offsets": [ [ 74, 90 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003520" } ] }, { "id": "3749", "type": "Disease", "text": [ "cystitis" ], "offsets": [ [ 99, 107 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003556" } ] }, { "id": "3750", "type": "Chemical", "text": [ "cyclophosphamide" ], "offsets": [ [ 123, 139 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003520" } ] }, { "id": "3751", "type": "Disease", "text": [ "cystitis" ], "offsets": [ [ 148, 156 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003556" } ] }, { "id": "3752", "type": "Disease", "text": [ "cystitis" ], "offsets": [ [ 323, 331 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003556" } ] }, { "id": "3753", "type": "Chemical", "text": [ "cyclophosphamide" ], "offsets": [ [ 417, 433 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003520" } ] }, { "id": "3754", "type": "Chemical", "text": [ "atropine" ], "offsets": [ [ 614, 622 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001285" } ] }, { "id": "3755", "type": "Chemical", "text": [ "alpha,beta-methylene adenosine-5'-triphosphate" ], "offsets": [ [ 830, 876 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C002630" } ] }, { "id": "3756", "type": "Chemical", "text": [ "alpha,beta-meATP" ], "offsets": [ [ 878, 894 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C002630" } ] }, { "id": "3757", "type": "Chemical", "text": [ "atropine" ], "offsets": [ [ 987, 995 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001285" } ] }, { "id": "3758", "type": "Chemical", "text": [ "4-diphenylacetoxy-N-methylpiperidine" ], "offsets": [ [ 997, 1033 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C042375" } ] }, { "id": "3759", "type": "Chemical", "text": [ "4-DAMP" ], "offsets": [ [ 1035, 1041 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C042375" } ] }, { "id": "3760", "type": "Chemical", "text": [ "methoctramine" ], "offsets": [ [ 1073, 1086 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C054938" } ] }, { "id": "3761", "type": "Chemical", "text": [ "pirenzepine" ], "offsets": [ [ 1110, 1121 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010890" } ] }, { "id": "3762", "type": "Chemical", "text": [ "4-DAMP" ], "offsets": [ [ 1278, 1284 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C042375" } ] }, { "id": "3763", "type": "Chemical", "text": [ "methoctramine" ], "offsets": [ [ 1349, 1362 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C054938" } ] }, { "id": "3764", "type": "Chemical", "text": [ "pirenzepine" ], "offsets": [ [ 1367, 1378 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010890" } ] }, { "id": "3765", "type": "Chemical", "text": [ "pirenzepine" ], "offsets": [ [ 1542, 1553 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010890" } ] }, { "id": "3766", "type": "Chemical", "text": [ "4-DAMP" ], "offsets": [ [ 1558, 1564 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C042375" } ] }, { "id": "3767", "type": "Chemical", "text": [ "methoctramine" ], "offsets": [ [ 1666, 1679 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C054938" } ] }, { "id": "3768", "type": "Chemical", "text": [ "carbachol" ], "offsets": [ [ 1780, 1789 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002217" } ] }, { "id": "3769", "type": "Chemical", "text": [ "ATP" ], "offsets": [ [ 1794, 1797 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000255" } ] }, { "id": "3770", "type": "Chemical", "text": [ "potassium" ], "offsets": [ [ 1874, 1883 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011188" } ] }, { "id": "3771", "type": "Chemical", "text": [ "isoprenaline" ], "offsets": [ [ 1894, 1906 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007545" } ] }, { "id": "3772", "type": "Disease", "text": [ "cystitis" ], "offsets": [ [ 1969, 1977 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003556" } ] } ]

[]

[]

[ { "id": "3773", "type": "CID", "arg1_id": "3748", "arg2_id": "3749", "normalized": [] }, { "id": "3774", "type": "CID", "arg1_id": "3748", "arg2_id": "3751", "normalized": [] }, { "id": "3775", "type": "CID", "arg1_id": "3748", "arg2_id": "3752", "normalized": [] }, { "id": "3776", "type": "CID", "arg1_id": "3748", "arg2_id": "3772", "normalized": [] }, { "id": "3777", "type": "CID", "arg1_id": "3750", "arg2_id": "3749", "normalized": [] }, { "id": "3778", "type": "CID", "arg1_id": "3750", "arg2_id": "3751", "normalized": [] }, { "id": "3779", "type": "CID", "arg1_id": "3750", "arg2_id": "3752", "normalized": [] }, { "id": "3780", "type": "CID", "arg1_id": "3750", "arg2_id": "3772", "normalized": [] }, { "id": "3781", "type": "CID", "arg1_id": "3753", "arg2_id": "3749", "normalized": [] }, { "id": "3782", "type": "CID", "arg1_id": "3753", "arg2_id": "3751", "normalized": [] }, { "id": "3783", "type": "CID", "arg1_id": "3753", "arg2_id": "3752", "normalized": [] }, { "id": "3784", "type": "CID", "arg1_id": "3753", "arg2_id": "3772", "normalized": [] } ]

[ { "id": "3786", "type": "title", "text": [ "Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive function: a non-randomised clinical study in the elderly." ], "offsets": [ [ 0, 163 ] ] }, { "id": "3787", "type": "abstract", "text": [ "OBJECTIVE: To describe associations between the use of benzodiazepines or related drugs (BZDs/RDs) and health, functional abilities and cognitive function in the elderly. METHODS: A non-randomised clinical study of patients aged > or =65 years admitted to acute hospital wards during 1 month. 164 patients (mean age +/- standard deviation [SD] 81.6 +/- 6.8 years) were admitted. Of these, nearly half (n = 78) had used BZDs/RDs before admission, and the remainder (n = 86) were non-users. Cognitive ability was assessed by the Mini-Mental State Examination (MMSE). Patients scoring > or =20 MMSE sum points were interviewed (n = 79) and questioned regarding symptoms and functional abilities during the week prior to admission. Data on use of BZDs/RDs before admission, current medications and discharge diagnoses were collected from medical records. Health, physical abilities and cognitive function were compared between BZD/RD users and non-users, and adjustments were made for confounding variables. The residual serum concentrations of oxazepam, temazepam and zopiclone were analysed. RESULTS: The mean +/- SD duration of BZD/RD use was 7 +/- 7 years (range 1-31). Two or three BZDs/RDs were concomitantly taken by 26% of users (n = 20). Long-term use of these drugs was associated with female sex and use of a higher number of drugs with effects on the CNS, which tended to be related to diagnosed dementia. After adjustment for these variables as confounders, use of BZDs/RDs was not associated with cognitive function as measured by the MMSE. However, use of BZDs/RDs was associated with dizziness, inability to sleep after awaking at night and tiredness in the mornings during the week prior to admission and with stronger depressive symptoms measured at the beginning of the hospital stay. Use of BZDs/RDs tended to be associated with a reduced ability to walk and shorter night-time sleep during the week prior to admission. A higher residual serum concentration of temazepam correlated with a lower MMSE sum score after adjustment for confounding variables. CONCLUSIONS: Long-term use and concomitant use of more than one BZD/RD were common in elderly patients hospitalised because of acute illnesses. Long-term use was associated with daytime and night-time symptoms indicative of poorer health and potentially caused by the adverse effects of these drugs." ], "offsets": [ [ 164, 2533 ] ] } ]

[ { "id": "3788", "type": "Chemical", "text": [ "benzodiazepines" ], "offsets": [ [ 28, 43 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3789", "type": "Chemical", "text": [ "benzodiazepines" ], "offsets": [ [ 219, 234 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3790", "type": "Chemical", "text": [ "BZDs" ], "offsets": [ [ 253, 257 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3791", "type": "Chemical", "text": [ "BZDs" ], "offsets": [ [ 583, 587 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3792", "type": "Chemical", "text": [ "BZDs" ], "offsets": [ [ 907, 911 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3793", "type": "Chemical", "text": [ "oxazepam" ], "offsets": [ [ 1205, 1213 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010076" } ] }, { "id": "3794", "type": "Chemical", "text": [ "temazepam" ], "offsets": [ [ 1215, 1224 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013693" } ] }, { "id": "3795", "type": "Chemical", "text": [ "zopiclone" ], "offsets": [ [ 1229, 1238 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C515050" } ] }, { "id": "3796", "type": "Chemical", "text": [ "BZDs" ], "offsets": [ [ 1347, 1351 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3797", "type": "Disease", "text": [ "dementia" ], "offsets": [ [ 1568, 1576 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003704" } ] }, { "id": "3798", "type": "Chemical", "text": [ "BZDs" ], "offsets": [ [ 1638, 1642 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3799", "type": "Chemical", "text": [ "BZDs" ], "offsets": [ [ 1731, 1735 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3800", "type": "Disease", "text": [ "dizziness" ], "offsets": [ [ 1760, 1769 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004244" } ] }, { "id": "3801", "type": "Disease", "text": [ "inability to sleep" ], "offsets": [ [ 1771, 1789 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007319" } ] }, { "id": "3802", "type": "Disease", "text": [ "tiredness" ], "offsets": [ [ 1817, 1826 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005221" } ] }, { "id": "3803", "type": "Disease", "text": [ "depressive symptoms" ], "offsets": [ [ 1896, 1915 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "3804", "type": "Chemical", "text": [ "BZDs" ], "offsets": [ [ 1971, 1975 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001569" } ] }, { "id": "3805", "type": "Chemical", "text": [ "temazepam" ], "offsets": [ [ 2141, 2150 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013693" } ] } ]

[]

[]

[ { "id": "3806", "type": "CID", "arg1_id": "3788", "arg2_id": "3802", "normalized": [] }, { "id": "3807", "type": "CID", "arg1_id": "3789", "arg2_id": "3802", "normalized": [] }, { "id": "3808", "type": "CID", "arg1_id": "3790", "arg2_id": "3802", "normalized": [] }, { "id": "3809", "type": "CID", "arg1_id": "3791", "arg2_id": "3802", "normalized": [] }, { "id": "3810", "type": "CID", "arg1_id": "3792", "arg2_id": "3802", "normalized": [] }, { "id": "3811", "type": "CID", "arg1_id": "3796", "arg2_id": "3802", "normalized": [] }, { "id": "3812", "type": "CID", "arg1_id": "3798", "arg2_id": "3802", "normalized": [] }, { "id": "3813", "type": "CID", "arg1_id": "3799", "arg2_id": "3802", "normalized": [] }, { "id": "3814", "type": "CID", "arg1_id": "3804", "arg2_id": "3802", "normalized": [] }, { "id": "3815", "type": "CID", "arg1_id": "3788", "arg2_id": "3803", "normalized": [] }, { "id": "3816", "type": "CID", "arg1_id": "3789", "arg2_id": "3803", "normalized": [] }, { "id": "3817", "type": "CID", "arg1_id": "3790", "arg2_id": "3803", "normalized": [] }, { "id": "3818", "type": "CID", "arg1_id": "3791", "arg2_id": "3803", "normalized": [] }, { "id": "3819", "type": "CID", "arg1_id": "3792", "arg2_id": "3803", "normalized": [] }, { "id": "3820", "type": "CID", "arg1_id": "3796", "arg2_id": "3803", "normalized": [] }, { "id": "3821", "type": "CID", "arg1_id": "3798", "arg2_id": "3803", "normalized": [] }, { "id": "3822", "type": "CID", "arg1_id": "3799", "arg2_id": "3803", "normalized": [] }, { "id": "3823", "type": "CID", "arg1_id": "3804", "arg2_id": "3803", "normalized": [] }, { "id": "3824", "type": "CID", "arg1_id": "3788", "arg2_id": "3801", "normalized": [] }, { "id": "3825", "type": "CID", "arg1_id": "3789", "arg2_id": "3801", "normalized": [] }, { "id": "3826", "type": "CID", "arg1_id": "3790", "arg2_id": "3801", "normalized": [] }, { "id": "3827", "type": "CID", "arg1_id": "3791", "arg2_id": "3801", "normalized": [] }, { "id": "3828", "type": "CID", "arg1_id": "3792", "arg2_id": "3801", "normalized": [] }, { "id": "3829", "type": "CID", "arg1_id": "3796", "arg2_id": "3801", "normalized": [] }, { "id": "3830", "type": "CID", "arg1_id": "3798", "arg2_id": "3801", "normalized": [] }, { "id": "3831", "type": "CID", "arg1_id": "3799", "arg2_id": "3801", "normalized": [] }, { "id": "3832", "type": "CID", "arg1_id": "3804", "arg2_id": "3801", "normalized": [] }, { "id": "3833", "type": "CID", "arg1_id": "3788", "arg2_id": "3800", "normalized": [] }, { "id": "3834", "type": "CID", "arg1_id": "3789", "arg2_id": "3800", "normalized": [] }, { "id": "3835", "type": "CID", "arg1_id": "3790", "arg2_id": "3800", "normalized": [] }, { "id": "3836", "type": "CID", "arg1_id": "3791", "arg2_id": "3800", "normalized": [] }, { "id": "3837", "type": "CID", "arg1_id": "3792", "arg2_id": "3800", "normalized": [] }, { "id": "3838", "type": "CID", "arg1_id": "3796", "arg2_id": "3800", "normalized": [] }, { "id": "3839", "type": "CID", "arg1_id": "3798", "arg2_id": "3800", "normalized": [] }, { "id": "3840", "type": "CID", "arg1_id": "3799", "arg2_id": "3800", "normalized": [] }, { "id": "3841", "type": "CID", "arg1_id": "3804", "arg2_id": "3800", "normalized": [] } ]

[ { "id": "3843", "type": "title", "text": [ "Acute vocal fold palsy after acute disulfiram intoxication." ], "offsets": [ [ 0, 59 ] ] }, { "id": "3844", "type": "abstract", "text": [ "Acute peripheral neuropathy caused by a disulfiram overdose is very rare and there is no report of it leading to vocal fold palsy. A 49-year-old woman was transferred to our department because of quadriparesis, lancinating pain, sensory loss, and paresthesia of the distal limbs. One month previously, she had taken a single high dose of disulfiram (130 tablets of ALCOHOL STOP TAB, Shin-Poong Pharm. Co., Ansan, Korea) in a suicide attempt. She was not an alcoholic. For the first few days after ingestion, she was in a confused state and had mild to moderate ataxia and giddiness. She noticed hoarseness and distally accentuated motor and sensory dysfunction after she had recovered from this state. A nerve conduction study was consistent with severe sensorimotor axonal polyneuropathy. Laryngeal electromyography (thyroarytenoid muscle) showed ample denervation potentials. Laryngoscopy revealed asymmetric vocal fold movements during phonation. Her vocal change and weakness began to improve spontaneously about 3 weeks after transfer. This was a case of acute palsy of the recurrent laryngeal nerve and superimposed severe acute sensorimotor axonal polyneuropathy caused by high-dose disulfiram intoxication." ], "offsets": [ [ 60, 1274 ] ] } ]

[ { "id": "3845", "type": "Disease", "text": [ "vocal fold palsy" ], "offsets": [ [ 6, 22 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014826" } ] }, { "id": "3846", "type": "Chemical", "text": [ "disulfiram" ], "offsets": [ [ 35, 45 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004221" } ] }, { "id": "3847", "type": "Disease", "text": [ "peripheral neuropathy" ], "offsets": [ [ 66, 87 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010523" } ] }, { "id": "3848", "type": "Chemical", "text": [ "disulfiram" ], "offsets": [ [ 100, 110 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004221" } ] }, { "id": "3849", "type": "Disease", "text": [ "overdose" ], "offsets": [ [ 111, 119 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D062787" } ] }, { "id": "3850", "type": "Disease", "text": [ "vocal fold palsy" ], "offsets": [ [ 173, 189 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014826" } ] }, { "id": "3851", "type": "Disease", "text": [ "quadriparesis" ], "offsets": [ [ 256, 269 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011782" } ] }, { "id": "3852", "type": "Disease", "text": [ "pain" ], "offsets": [ [ 283, 287 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010146" } ] }, { "id": "3853", "type": "Disease", "text": [ "sensory loss" ], "offsets": [ [ 289, 301 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C580162" } ] }, { "id": "3854", "type": "Disease", "text": [ "paresthesia" ], "offsets": [ [ 307, 318 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010292" } ] }, { "id": "3855", "type": "Chemical", "text": [ "disulfiram" ], "offsets": [ [ 398, 408 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004221" } ] }, { "id": "3856", "type": "Chemical", "text": [ "ALCOHOL" ], "offsets": [ [ 425, 432 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000431" } ] }, { "id": "3857", "type": "Disease", "text": [ "ataxia" ], "offsets": [ [ 621, 627 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001259" } ] }, { "id": "3858", "type": "Disease", "text": [ "giddiness" ], "offsets": [ [ 632, 641 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004244" } ] }, { "id": "3859", "type": "Disease", "text": [ "hoarseness" ], "offsets": [ [ 655, 665 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006685" } ] }, { "id": "3860", "type": "Disease", "text": [ "polyneuropathy" ], "offsets": [ [ 834, 848 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011115" } ] }, { "id": "3861", "type": "Disease", "text": [ "palsy" ], "offsets": [ [ 1126, 1131 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010243" } ] }, { "id": "3862", "type": "Disease", "text": [ "polyneuropathy" ], "offsets": [ [ 1215, 1229 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011115" } ] }, { "id": "3863", "type": "Chemical", "text": [ "disulfiram" ], "offsets": [ [ 1250, 1260 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004221" } ] } ]

[]

[]

[ { "id": "3864", "type": "CID", "arg1_id": "3846", "arg2_id": "3854", "normalized": [] }, { "id": "3865", "type": "CID", "arg1_id": "3848", "arg2_id": "3854", "normalized": [] }, { "id": "3866", "type": "CID", "arg1_id": "3855", "arg2_id": "3854", "normalized": [] }, { "id": "3867", "type": "CID", "arg1_id": "3863", "arg2_id": "3854", "normalized": [] }, { "id": "3868", "type": "CID", "arg1_id": "3846", "arg2_id": "3851", "normalized": [] }, { "id": "3869", "type": "CID", "arg1_id": "3848", "arg2_id": "3851", "normalized": [] }, { "id": "3870", "type": "CID", "arg1_id": "3855", "arg2_id": "3851", "normalized": [] }, { "id": "3871", "type": "CID", "arg1_id": "3863", "arg2_id": "3851", "normalized": [] }, { "id": "3872", "type": "CID", "arg1_id": "3846", "arg2_id": "3852", "normalized": [] }, { "id": "3873", "type": "CID", "arg1_id": "3848", "arg2_id": "3852", "normalized": [] }, { "id": "3874", "type": "CID", "arg1_id": "3855", "arg2_id": "3852", "normalized": [] }, { "id": "3875", "type": "CID", "arg1_id": "3863", "arg2_id": "3852", "normalized": [] }, { "id": "3876", "type": "CID", "arg1_id": "3846", "arg2_id": "3847", "normalized": [] }, { "id": "3877", "type": "CID", "arg1_id": "3848", "arg2_id": "3847", "normalized": [] }, { "id": "3878", "type": "CID", "arg1_id": "3855", "arg2_id": "3847", "normalized": [] }, { "id": "3879", "type": "CID", "arg1_id": "3863", "arg2_id": "3847", "normalized": [] }, { "id": "3880", "type": "CID", "arg1_id": "3846", "arg2_id": "3857", "normalized": [] }, { "id": "3881", "type": "CID", "arg1_id": "3848", "arg2_id": "3857", "normalized": [] }, { "id": "3882", "type": "CID", "arg1_id": "3855", "arg2_id": "3857", "normalized": [] }, { "id": "3883", "type": "CID", "arg1_id": "3863", "arg2_id": "3857", "normalized": [] }, { "id": "3884", "type": "CID", "arg1_id": "3846", "arg2_id": "3845", "normalized": [] }, { "id": "3885", "type": "CID", "arg1_id": "3846", "arg2_id": "3850", "normalized": [] }, { "id": "3886", "type": "CID", "arg1_id": "3848", "arg2_id": "3845", "normalized": [] }, { "id": "3887", "type": "CID", "arg1_id": "3848", "arg2_id": "3850", "normalized": [] }, { "id": "3888", "type": "CID", "arg1_id": "3855", "arg2_id": "3845", "normalized": [] }, { "id": "3889", "type": "CID", "arg1_id": "3855", "arg2_id": "3850", "normalized": [] }, { "id": "3890", "type": "CID", "arg1_id": "3863", "arg2_id": "3845", "normalized": [] }, { "id": "3891", "type": "CID", "arg1_id": "3863", "arg2_id": "3850", "normalized": [] } ]

[ { "id": "3893", "type": "title", "text": [ "Higher optical density of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia." ], "offsets": [ [ 0, 113 ] ] }, { "id": "3894", "type": "abstract", "text": [ "OBJECTIVES: To correlate optical density and percent inhibition of a two-step heparin-induced thrombocytopenia (HIT) antigen assay with thrombosis; the assay utilizes reaction inhibition characteristics of a high heparin concentration. PATIENTS AND METHODS: Patients with more than 50% decrease in platelet count or thrombocytopenia (<150 x 10(9)/L) after exposure to heparin, who had a positive two-step antigen assay [optical density (OD) >0.4 and >50 inhibition with high concentration of heparin] were included in the study. RESULTS: Forty of 94 HIT patients had thrombosis at diagnosis; 54/94 had isolated-HIT without thrombosis. Eight of the isolated-HIT patients developed thrombosis within the next 30 d; thus, a total of 48 patients had thrombosis at day 30. At diagnosis there was no significant difference in OD between HIT patients with thrombosis and those with isolated-HIT. However, OD was significantly higher in all patients with thrombosis (n = 48, 1.34 +/- 0.89), including isolated-HIT patients who later developed thrombosis within 30 d (n = 8, 1.84 +/- 0.64) as compared to isolated-HIT patients who did not develop thrombosis (0.96 +/- 0.75; P = 0.011 and P = 0.008). The Receiver Operative Characteristic Curve showed that OD >1.27 in the isolated-HIT group had a significantly higher chance of developing thrombosis by day 30. None of these groups showed significant difference in percent inhibition. Multivariate analysis showed a 2.8-fold increased risk of thrombosis in females. Similarly, thrombotic risk increased with age and OD values. CONCLUSION: Higher OD is associated with significant risk of subsequent thrombosis in patients with isolated-HIT; percent inhibition, however, was not predictive." ], "offsets": [ [ 114, 1844 ] ] } ]

[ { "id": "3895", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 52, 62 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3896", "type": "Chemical", "text": [ "heparin" ], "offsets": [ [ 80, 87 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006493" } ] }, { "id": "3897", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 96, 112 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3898", "type": "Chemical", "text": [ "heparin" ], "offsets": [ [ 192, 199 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006493" } ] }, { "id": "3899", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 208, 224 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3900", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 226, 229 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3901", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 250, 260 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3902", "type": "Chemical", "text": [ "heparin" ], "offsets": [ [ 327, 334 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006493" } ] }, { "id": "3903", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 430, 446 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3904", "type": "Chemical", "text": [ "heparin" ], "offsets": [ [ 482, 489 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006493" } ] }, { "id": "3905", "type": "Chemical", "text": [ "heparin" ], "offsets": [ [ 606, 613 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006493" } ] }, { "id": "3906", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 664, 667 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3907", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 681, 691 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3908", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 725, 728 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3909", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 737, 747 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3910", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 771, 774 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3911", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 794, 804 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3912", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 860, 870 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3913", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 945, 948 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3914", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 963, 973 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3915", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 998, 1001 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3916", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 1061, 1071 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3917", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 1116, 1119 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3918", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 1149, 1159 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3919", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 1219, 1222 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3920", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 1252, 1262 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3921", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 1386, 1389 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "3922", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 1444, 1454 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3923", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 1598, 1608 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3924", "type": "Disease", "text": [ "thrombotic" ], "offsets": [ [ 1632, 1642 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3925", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 1754, 1764 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "3926", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 1791, 1794 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] } ]

[]

[]

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"type": "CID", "arg1_id": "3896", "arg2_id": "3923", "normalized": [] }, { "id": "3939", "type": "CID", "arg1_id": "3896", "arg2_id": "3924", "normalized": [] }, { "id": "3940", "type": "CID", "arg1_id": "3896", "arg2_id": "3925", "normalized": [] }, { "id": "3941", "type": "CID", "arg1_id": "3898", "arg2_id": "3895", "normalized": [] }, { "id": "3942", "type": "CID", "arg1_id": "3898", "arg2_id": "3901", "normalized": [] }, { "id": "3943", "type": "CID", "arg1_id": "3898", "arg2_id": "3907", "normalized": [] }, { "id": "3944", "type": "CID", "arg1_id": "3898", "arg2_id": "3909", "normalized": [] }, { "id": "3945", "type": "CID", "arg1_id": "3898", "arg2_id": "3911", "normalized": [] }, { "id": "3946", "type": "CID", "arg1_id": "3898", "arg2_id": "3912", "normalized": [] }, { "id": "3947", "type": "CID", "arg1_id": "3898", "arg2_id": "3914", "normalized": [] }, { "id": "3948", "type": "CID", "arg1_id": "3898", "arg2_id": "3916", "normalized": [] }, { "id": "3949", "type": "CID", "arg1_id": "3898", "arg2_id": "3918", "normalized": [] }, { "id": "3950", "type": "CID", "arg1_id": "3898", "arg2_id": "3920", "normalized": [] }, { "id": "3951", "type": "CID", "arg1_id": "3898", "arg2_id": "3922", "normalized": [] }, { "id": "3952", "type": "CID", "arg1_id": "3898", "arg2_id": "3923", "normalized": [] }, { "id": "3953", "type": "CID", "arg1_id": "3898", "arg2_id": "3924", "normalized": [] }, { "id": "3954", "type": "CID", "arg1_id": "3898", "arg2_id": "3925", "normalized": [] }, { "id": "3955", "type": "CID", "arg1_id": "3902", "arg2_id": "3895", "normalized": [] }, { "id": "3956", "type": "CID", "arg1_id": "3902", "arg2_id": "3901", "normalized": [] }, { "id": "3957", "type": "CID", "arg1_id": "3902", "arg2_id": "3907", "normalized": [] }, { "id": "3958", "type": "CID", "arg1_id": "3902", "arg2_id": "3909", "normalized": [] }, { "id": "3959", "type": "CID", "arg1_id": "3902", "arg2_id": "3911", "normalized": [] }, { "id": "3960", "type": "CID", "arg1_id": "3902", "arg2_id": "3912", "normalized": [] }, { "id": "3961", "type": "CID", "arg1_id": "3902", "arg2_id": "3914", "normalized": [] }, { "id": "3962", "type": "CID", "arg1_id": "3902", "arg2_id": "3916", "normalized": [] }, { "id": "3963", "type": "CID", "arg1_id": "3902", "arg2_id": "3918", "normalized": [] }, { "id": "3964", "type": "CID", "arg1_id": "3902", "arg2_id": "3920", "normalized": [] }, { "id": "3965", "type": "CID", "arg1_id": "3902", "arg2_id": "3922", "normalized": [] }, { "id": "3966", "type": "CID", "arg1_id": "3902", "arg2_id": "3923", "normalized": [] }, { "id": "3967", "type": "CID", "arg1_id": "3902", "arg2_id": "3924", "normalized": [] }, { "id": "3968", "type": "CID", "arg1_id": "3902", "arg2_id": "3925", "normalized": [] }, { "id": "3969", "type": "CID", "arg1_id": "3904", "arg2_id": "3895", "normalized": [] }, { "id": "3970", "type": "CID", "arg1_id": "3904", "arg2_id": "3901", "normalized": [] }, { "id": "3971", "type": "CID", "arg1_id": "3904", "arg2_id": "3907", "normalized": [] }, { "id": "3972", "type": "CID", "arg1_id": "3904", "arg2_id": "3909", "normalized": [] }, { "id": "3973", "type": "CID", "arg1_id": "3904", "arg2_id": "3911", "normalized": [] }, { "id": "3974", "type": "CID", "arg1_id": "3904", "arg2_id": "3912", "normalized": [] }, { "id": "3975", "type": "CID", "arg1_id": "3904", "arg2_id": "3914", "normalized": [] }, { "id": "3976", "type": "CID", "arg1_id": "3904", "arg2_id": "3916", "normalized": [] }, { "id": "3977", "type": "CID", "arg1_id": "3904", "arg2_id": "3918", "normalized": [] }, { "id": "3978", "type": "CID", "arg1_id": "3904", "arg2_id": "3920", "normalized": [] }, { "id": "3979", "type": "CID", "arg1_id": "3904", "arg2_id": "3922", "normalized": [] }, { "id": "3980", "type": "CID", "arg1_id": "3904", "arg2_id": "3923", "normalized": [] }, { "id": "3981", "type": "CID", "arg1_id": "3904", "arg2_id": "3924", "normalized": [] }, { "id": "3982", "type": "CID", "arg1_id": "3904", "arg2_id": "3925", "normalized": [] }, { "id": "3983", "type": "CID", "arg1_id": "3905", "arg2_id": "3895", "normalized": [] }, { "id": "3984", "type": "CID", "arg1_id": "3905", "arg2_id": "3901", "normalized": [] }, { "id": "3985", "type": "CID", "arg1_id": "3905", "arg2_id": "3907", "normalized": [] }, { "id": "3986", "type": "CID", "arg1_id": "3905", "arg2_id": "3909", "normalized": [] }, { "id": "3987", "type": "CID", "arg1_id": "3905", "arg2_id": "3911", "normalized": [] }, { "id": "3988", "type": "CID", "arg1_id": "3905", "arg2_id": "3912", "normalized": [] }, { "id": "3989", "type": "CID", "arg1_id": "3905", "arg2_id": "3914", "normalized": [] }, { "id": "3990", "type": "CID", "arg1_id": "3905", "arg2_id": "3916", "normalized": [] }, { "id": "3991", "type": "CID", "arg1_id": "3905", "arg2_id": "3918", "normalized": [] }, { "id": "3992", "type": "CID", "arg1_id": "3905", "arg2_id": "3920", "normalized": [] }, { "id": "3993", "type": "CID", "arg1_id": "3905", "arg2_id": "3922", "normalized": [] }, { "id": "3994", "type": "CID", "arg1_id": "3905", "arg2_id": "3923", "normalized": [] }, { "id": "3995", "type": "CID", "arg1_id": "3905", "arg2_id": "3924", "normalized": [] }, { "id": "3996", "type": "CID", "arg1_id": "3905", "arg2_id": "3925", "normalized": [] }, { "id": "3997", "type": "CID", "arg1_id": "3896", "arg2_id": "3897", "normalized": [] }, { "id": "3998", "type": "CID", "arg1_id": "3896", "arg2_id": "3899", "normalized": [] }, { "id": "3999", "type": "CID", "arg1_id": "3896", "arg2_id": "3900", "normalized": [] }, { "id": "4000", "type": "CID", "arg1_id": "3896", "arg2_id": "3903", "normalized": [] }, { "id": "4001", "type": "CID", "arg1_id": "3896", "arg2_id": "3906", "normalized": [] }, { "id": "4002", "type": "CID", "arg1_id": "3896", "arg2_id": "3908", "normalized": [] }, { "id": "4003", "type": "CID", "arg1_id": "3896", "arg2_id": "3910", "normalized": [] }, { "id": "4004", "type": "CID", "arg1_id": "3896", "arg2_id": "3913", "normalized": [] }, { "id": "4005", "type": "CID", "arg1_id": "3896", "arg2_id": "3915", "normalized": [] }, { "id": "4006", "type": "CID", "arg1_id": "3896", "arg2_id": "3917", "normalized": [] }, { "id": "4007", "type": "CID", "arg1_id": "3896", "arg2_id": "3919", "normalized": [] }, { "id": "4008", "type": "CID", "arg1_id": "3896", "arg2_id": "3921", "normalized": [] }, { "id": "4009", "type": "CID", "arg1_id": "3896", "arg2_id": "3926", "normalized": [] }, { "id": "4010", "type": "CID", "arg1_id": "3898", "arg2_id": "3897", "normalized": [] }, { "id": "4011", "type": "CID", "arg1_id": "3898", "arg2_id": "3899", "normalized": [] }, { "id": "4012", "type": "CID", "arg1_id": "3898", "arg2_id": "3900", "normalized": [] }, { "id": "4013", "type": "CID", "arg1_id": "3898", "arg2_id": "3903", "normalized": [] }, { "id": "4014", "type": "CID", "arg1_id": "3898", "arg2_id": "3906", "normalized": [] }, { "id": "4015", "type": "CID", "arg1_id": "3898", "arg2_id": "3908", "normalized": [] }, { "id": "4016", "type": "CID", "arg1_id": "3898", "arg2_id": "3910", "normalized": [] }, { "id": "4017", "type": "CID", "arg1_id": "3898", "arg2_id": "3913", "normalized": [] }, { "id": "4018", "type": "CID", "arg1_id": "3898", "arg2_id": "3915", "normalized": [] }, { "id": "4019", "type": "CID", "arg1_id": "3898", "arg2_id": "3917", "normalized": [] }, { "id": "4020", "type": "CID", "arg1_id": "3898", "arg2_id": "3919", "normalized": [] }, { "id": "4021", "type": "CID", "arg1_id": "3898", "arg2_id": "3921", "normalized": [] }, { "id": "4022", "type": "CID", "arg1_id": "3898", "arg2_id": "3926", "normalized": [] }, { "id": "4023", "type": "CID", "arg1_id": "3902", "arg2_id": "3897", "normalized": [] }, { "id": "4024", "type": "CID", "arg1_id": "3902", "arg2_id": "3899", "normalized": [] }, { "id": "4025", "type": "CID", "arg1_id": "3902", "arg2_id": "3900", "normalized": [] }, { "id": "4026", "type": "CID", "arg1_id": "3902", "arg2_id": "3903", "normalized": [] }, { "id": "4027", "type": "CID", "arg1_id": "3902", "arg2_id": "3906", "normalized": [] }, { "id": "4028", "type": "CID", "arg1_id": "3902", "arg2_id": "3908", "normalized": [] }, { "id": "4029", "type": "CID", "arg1_id": "3902", "arg2_id": "3910", "normalized": [] }, { "id": "4030", "type": "CID", "arg1_id": "3902", "arg2_id": "3913", "normalized": [] }, { "id": "4031", "type": "CID", "arg1_id": "3902", "arg2_id": "3915", "normalized": [] }, { "id": "4032", "type": "CID", "arg1_id": "3902", "arg2_id": "3917", "normalized": [] }, { "id": "4033", "type": "CID", "arg1_id": "3902", "arg2_id": "3919", "normalized": [] }, { "id": "4034", "type": "CID", "arg1_id": "3902", "arg2_id": "3921", "normalized": [] }, { "id": "4035", "type": "CID", "arg1_id": "3902", "arg2_id": "3926", "normalized": [] }, { "id": "4036", "type": "CID", "arg1_id": "3904", "arg2_id": "3897", "normalized": [] }, { "id": "4037", "type": "CID", "arg1_id": "3904", "arg2_id": "3899", "normalized": [] }, { "id": "4038", "type": "CID", "arg1_id": "3904", "arg2_id": "3900", "normalized": [] }, { "id": "4039", "type": "CID", "arg1_id": "3904", "arg2_id": "3903", "normalized": [] }, { "id": "4040", "type": "CID", "arg1_id": "3904", "arg2_id": "3906", "normalized": [] }, { "id": "4041", "type": "CID", "arg1_id": "3904", "arg2_id": "3908", "normalized": [] }, { "id": "4042", "type": "CID", "arg1_id": "3904", "arg2_id": "3910", "normalized": [] }, { "id": "4043", "type": "CID", "arg1_id": "3904", "arg2_id": "3913", "normalized": [] }, { "id": "4044", "type": "CID", "arg1_id": "3904", "arg2_id": "3915", "normalized": [] }, { "id": "4045", "type": "CID", "arg1_id": "3904", "arg2_id": "3917", "normalized": [] }, { "id": "4046", "type": "CID", "arg1_id": "3904", "arg2_id": "3919", "normalized": [] }, { "id": "4047", "type": "CID", "arg1_id": "3904", "arg2_id": "3921", "normalized": [] }, { "id": "4048", "type": "CID", "arg1_id": "3904", "arg2_id": "3926", "normalized": [] }, { "id": "4049", "type": "CID", "arg1_id": "3905", "arg2_id": "3897", "normalized": [] }, { "id": "4050", "type": "CID", "arg1_id": "3905", "arg2_id": "3899", "normalized": [] }, { "id": "4051", "type": "CID", "arg1_id": "3905", "arg2_id": "3900", "normalized": [] }, { "id": "4052", "type": "CID", "arg1_id": "3905", "arg2_id": "3903", "normalized": [] }, { "id": "4053", "type": "CID", "arg1_id": "3905", "arg2_id": "3906", "normalized": [] }, { "id": "4054", "type": "CID", "arg1_id": "3905", "arg2_id": "3908", "normalized": [] }, { "id": "4055", "type": "CID", "arg1_id": "3905", "arg2_id": "3910", "normalized": [] }, { "id": "4056", "type": "CID", "arg1_id": "3905", "arg2_id": "3913", "normalized": [] }, { "id": "4057", "type": "CID", "arg1_id": "3905", "arg2_id": "3915", "normalized": [] }, { "id": "4058", "type": "CID", "arg1_id": "3905", "arg2_id": "3917", "normalized": [] }, { "id": "4059", "type": "CID", "arg1_id": "3905", "arg2_id": "3919", "normalized": [] }, { "id": "4060", "type": "CID", "arg1_id": "3905", "arg2_id": "3921", "normalized": [] }, { "id": "4061", "type": "CID", "arg1_id": "3905", "arg2_id": "3926", "normalized": [] } ]

[ { "id": "4063", "type": "title", "text": [ "Central retinal vein occlusion associated with clomiphene-induced ovulation." ], "offsets": [ [ 0, 76 ] ] }, { "id": "4064", "type": "abstract", "text": [ "OBJECTIVE: To report a case of central retinal vein occlusion associated with clomiphene citrate (CC). DESIGN: Case study. SETTING: Ophthalmology clinic of an academic hospital. PATIENT(S): A 36-year-old woman referred from the infertility clinic for blurred vision. INTERVENTION(S): Ophthalmic examination after CC therapy. MAIN OUTCOME MEASURE(S): Central retinal vein occlusion after ovulation induction with CC. RESULT(S): A 36-year-old Chinese woman developed central retinal vein occlusion after eight courses of CC. A search of the literature on the thromboembolic complications of CC does not include this severe ophthalmic complication, although mild visual disturbance after CC intake is not uncommon. CONCLUSION(S): This is the first reported case of central retinal vein occlusion after treatment with CC. Extra caution is warranted in treating infertility patients with CC, and patients should be well informed of this side effect before commencement of therapy." ], "offsets": [ [ 77, 1052 ] ] } ]

[ { "id": "4065", "type": "Disease", "text": [ "retinal vein occlusion" ], "offsets": [ [ 8, 30 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012170" } ] }, { "id": "4066", "type": "Chemical", "text": [ "clomiphene" ], "offsets": [ [ 47, 57 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4067", "type": "Disease", "text": [ "retinal vein occlusion" ], "offsets": [ [ 116, 138 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012170" } ] }, { "id": "4068", "type": "Chemical", "text": [ "clomiphene citrate" ], "offsets": [ [ 155, 173 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4069", "type": "Chemical", "text": [ "CC" ], "offsets": [ [ 175, 177 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4070", "type": "Disease", "text": [ "infertility" ], "offsets": [ [ 305, 316 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007247" } ] }, { "id": "4071", "type": "Disease", "text": [ "blurred vision" ], "offsets": [ [ 328, 342 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" } ] }, { "id": "4072", "type": "Chemical", "text": [ "CC" ], "offsets": [ [ 390, 392 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4073", "type": "Disease", "text": [ "retinal vein occlusion" ], "offsets": [ [ 435, 457 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012170" } ] }, { "id": "4074", "type": "Chemical", "text": [ "CC" ], "offsets": [ [ 489, 491 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4075", "type": "Disease", "text": [ "retinal vein occlusion" ], "offsets": [ [ 550, 572 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012170" } ] }, { "id": "4076", "type": "Chemical", "text": [ "CC" ], "offsets": [ [ 596, 598 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4077", "type": "Disease", "text": [ "thromboembolic" ], "offsets": [ [ 634, 648 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013923" } ] }, { "id": "4078", "type": "Chemical", "text": [ "CC" ], "offsets": [ [ 666, 668 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4079", "type": "Disease", "text": [ "visual disturbance" ], "offsets": [ [ 737, 755 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014786" } ] }, { "id": "4080", "type": "Chemical", "text": [ "CC" ], "offsets": [ [ 762, 764 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4081", "type": "Disease", "text": [ "retinal vein occlusion" ], "offsets": [ [ 847, 869 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012170" } ] }, { "id": "4082", "type": "Chemical", "text": [ "CC" ], "offsets": [ [ 891, 893 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] }, { "id": "4083", "type": "Disease", "text": [ "infertility" ], "offsets": [ [ 934, 945 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007247" } ] }, { "id": "4084", "type": "Chemical", "text": [ "CC" ], "offsets": [ [ 960, 962 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002996" } ] } ]

[]

[]

[ { "id": "4085", "type": "CID", "arg1_id": "4066", "arg2_id": "4065", "normalized": [] }, { "id": "4086", "type": "CID", "arg1_id": "4066", "arg2_id": "4067", "normalized": [] }, { "id": "4087", "type": "CID", "arg1_id": "4066", "arg2_id": "4073", "normalized": [] }, { "id": "4088", "type": "CID", "arg1_id": "4066", "arg2_id": "4075", "normalized": [] }, { "id": "4089", "type": "CID", "arg1_id": "4066", "arg2_id": "4081", "normalized": [] }, { "id": "4090", "type": "CID", "arg1_id": "4068", "arg2_id": "4065", "normalized": [] }, { "id": "4091", "type": "CID", "arg1_id": "4068", "arg2_id": "4067", "normalized": [] }, { "id": "4092", "type": "CID", "arg1_id": "4068", "arg2_id": "4073", "normalized": [] }, { "id": "4093", "type": "CID", "arg1_id": "4068", "arg2_id": "4075", "normalized": [] }, { "id": "4094", "type": "CID", "arg1_id": "4068", "arg2_id": "4081", "normalized": [] }, { "id": "4095", "type": "CID", "arg1_id": "4069", "arg2_id": "4065", "normalized": [] }, { "id": "4096", "type": "CID", "arg1_id": "4069", "arg2_id": "4067", "normalized": [] }, { "id": "4097", "type": "CID", "arg1_id": "4069", "arg2_id": "4073", "normalized": [] }, { "id": "4098", "type": "CID", "arg1_id": "4069", "arg2_id": "4075", "normalized": [] }, { "id": "4099", "type": "CID", "arg1_id": "4069", "arg2_id": "4081", "normalized": [] }, { "id": "4100", "type": "CID", "arg1_id": "4072", "arg2_id": "4065", "normalized": [] }, { "id": "4101", "type": "CID", "arg1_id": "4072", "arg2_id": "4067", "normalized": [] }, { "id": "4102", "type": "CID", "arg1_id": "4072", "arg2_id": "4073", "normalized": [] }, { "id": "4103", "type": "CID", "arg1_id": "4072", "arg2_id": "4075", "normalized": [] }, { "id": "4104", "type": "CID", "arg1_id": "4072", "arg2_id": "4081", "normalized": [] }, { "id": "4105", "type": "CID", "arg1_id": "4074", "arg2_id": "4065", "normalized": [] }, { "id": "4106", "type": "CID", "arg1_id": "4074", "arg2_id": "4067", "normalized": [] }, { "id": "4107", "type": "CID", "arg1_id": "4074", "arg2_id": "4073", "normalized": [] }, { "id": "4108", "type": "CID", "arg1_id": "4074", "arg2_id": "4075", "normalized": [] }, { "id": "4109", "type": "CID", "arg1_id": "4074", "arg2_id": "4081", "normalized": [] }, { "id": "4110", "type": "CID", "arg1_id": "4076", "arg2_id": "4065", "normalized": [] }, { "id": "4111", "type": "CID", "arg1_id": "4076", "arg2_id": "4067", "normalized": [] }, { "id": "4112", "type": "CID", "arg1_id": "4076", "arg2_id": "4073", "normalized": [] }, { "id": "4113", "type": "CID", "arg1_id": "4076", "arg2_id": "4075", "normalized": [] }, { "id": "4114", "type": "CID", "arg1_id": "4076", "arg2_id": "4081", "normalized": [] }, { "id": "4115", "type": "CID", "arg1_id": "4078", "arg2_id": "4065", "normalized": [] }, { "id": "4116", "type": "CID", "arg1_id": "4078", "arg2_id": "4067", "normalized": [] }, { "id": "4117", "type": "CID", "arg1_id": "4078", "arg2_id": "4073", "normalized": [] }, { "id": "4118", "type": "CID", "arg1_id": "4078", "arg2_id": "4075", "normalized": [] }, { "id": "4119", "type": "CID", "arg1_id": "4078", "arg2_id": "4081", "normalized": [] }, { "id": "4120", "type": "CID", "arg1_id": "4080", "arg2_id": "4065", "normalized": [] }, { "id": "4121", "type": "CID", "arg1_id": "4080", "arg2_id": "4067", "normalized": [] }, { "id": "4122", "type": "CID", "arg1_id": "4080", "arg2_id": "4073", "normalized": [] }, { "id": "4123", "type": "CID", "arg1_id": "4080", "arg2_id": "4075", "normalized": [] }, { "id": "4124", "type": "CID", "arg1_id": "4080", "arg2_id": "4081", "normalized": [] }, { "id": "4125", "type": "CID", "arg1_id": "4082", "arg2_id": "4065", "normalized": [] }, { "id": "4126", "type": "CID", "arg1_id": "4082", "arg2_id": "4067", "normalized": [] }, { "id": "4127", "type": "CID", "arg1_id": "4082", "arg2_id": "4073", "normalized": [] }, { "id": "4128", "type": "CID", "arg1_id": "4082", "arg2_id": "4075", "normalized": [] }, { "id": "4129", "type": "CID", "arg1_id": "4082", "arg2_id": "4081", "normalized": [] }, { "id": "4130", "type": "CID", "arg1_id": "4084", "arg2_id": "4065", "normalized": [] }, { "id": "4131", "type": "CID", "arg1_id": "4084", "arg2_id": "4067", "normalized": [] }, { "id": "4132", "type": "CID", "arg1_id": "4084", "arg2_id": "4073", "normalized": [] }, { "id": "4133", "type": "CID", "arg1_id": "4084", "arg2_id": "4075", "normalized": [] }, { "id": "4134", "type": "CID", "arg1_id": "4084", "arg2_id": "4081", "normalized": [] }, { "id": "4135", "type": "CID", "arg1_id": "4066", "arg2_id": "4071", "normalized": [] }, { "id": "4136", "type": "CID", "arg1_id": "4066", "arg2_id": "4079", "normalized": [] }, { "id": "4137", "type": "CID", "arg1_id": "4068", "arg2_id": "4071", "normalized": [] }, { "id": "4138", "type": "CID", "arg1_id": "4068", "arg2_id": "4079", "normalized": [] }, { "id": "4139", "type": "CID", "arg1_id": "4069", "arg2_id": "4071", "normalized": [] }, { "id": "4140", "type": "CID", "arg1_id": "4069", "arg2_id": "4079", "normalized": [] }, { "id": "4141", "type": "CID", "arg1_id": "4072", "arg2_id": "4071", "normalized": [] }, { "id": "4142", "type": "CID", "arg1_id": "4072", "arg2_id": "4079", "normalized": [] }, { "id": "4143", "type": "CID", "arg1_id": "4074", "arg2_id": "4071", "normalized": [] }, { "id": "4144", "type": "CID", "arg1_id": "4074", "arg2_id": "4079", "normalized": [] }, { "id": "4145", "type": "CID", "arg1_id": "4076", "arg2_id": "4071", "normalized": [] }, { "id": "4146", "type": "CID", "arg1_id": "4076", "arg2_id": "4079", "normalized": [] }, { "id": "4147", "type": "CID", "arg1_id": "4078", "arg2_id": "4071", "normalized": [] }, { "id": "4148", "type": "CID", "arg1_id": "4078", "arg2_id": "4079", "normalized": [] }, { "id": "4149", "type": "CID", "arg1_id": "4080", "arg2_id": "4071", "normalized": [] }, { "id": "4150", "type": "CID", "arg1_id": "4080", "arg2_id": "4079", "normalized": [] }, { "id": "4151", "type": "CID", "arg1_id": "4082", "arg2_id": "4071", "normalized": [] }, { "id": "4152", "type": "CID", "arg1_id": "4082", "arg2_id": "4079", "normalized": [] }, { "id": "4153", "type": "CID", "arg1_id": "4084", "arg2_id": "4071", "normalized": [] }, { "id": "4154", "type": "CID", "arg1_id": "4084", "arg2_id": "4079", "normalized": [] } ]

[ { "id": "4156", "type": "title", "text": [ "Nicotine-induced nystagmus correlates with midpontine activation." ], "offsets": [ [ 0, 65 ] ] }, { "id": "4157", "type": "abstract", "text": [ "The pathomechanism of nicotine-induced nystagmus (NIN) is unknown. The aim of this study was to delineate brain structures that are involved in NIN generation. Eight healthy volunteers inhaled nicotine in darkness during a functional magnetic resonance imaging (fMRI) experiment; eye movements were registered using video-oculography. NIN correlated with blood oxygen level-dependent (BOLD) activity levels in a midpontine site in the posterior basis pontis. NIN-induced midpontine activation may correspond to activation of the dorsomedial pontine nuclei and the nucleus reticularis tegmenti pontis, structures known to participate in the generation of multidirectional saccades and smooth pursuit eye movements." ], "offsets": [ [ 66, 779 ] ] } ]

[ { "id": "4158", "type": "Chemical", "text": [ "Nicotine" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "4159", "type": "Disease", "text": [ "nystagmus" ], "offsets": [ [ 17, 26 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009759" } ] }, { "id": "4160", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 88, 96 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "4161", "type": "Disease", "text": [ "nystagmus" ], "offsets": [ [ 105, 114 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009759" } ] }, { "id": "4162", "type": "Disease", "text": [ "NIN" ], "offsets": [ [ 116, 119 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009759" } ] }, { "id": "4163", "type": "Disease", "text": [ "NIN" ], "offsets": [ [ 210, 213 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009759" } ] }, { "id": "4164", "type": "Chemical", "text": [ "nicotine" ], "offsets": [ [ 259, 267 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009538" } ] }, { "id": "4165", "type": "Disease", "text": [ "NIN" ], "offsets": [ [ 401, 404 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009759" } ] }, { "id": "4166", "type": "Chemical", "text": [ "oxygen" ], "offsets": [ [ 427, 433 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010100" } ] }, { "id": "4167", "type": "Disease", "text": [ "NIN" ], "offsets": [ [ 525, 528 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009759" } ] } ]

[]

[]

[ { "id": "4168", "type": "CID", "arg1_id": "4158", "arg2_id": "4159", "normalized": [] }, { "id": "4169", "type": "CID", "arg1_id": "4158", "arg2_id": "4161", "normalized": [] }, { "id": "4170", "type": "CID", "arg1_id": "4158", "arg2_id": "4162", "normalized": [] }, { "id": "4171", "type": "CID", "arg1_id": "4158", "arg2_id": "4163", "normalized": [] }, { "id": "4172", "type": "CID", "arg1_id": "4158", "arg2_id": "4165", "normalized": [] }, { "id": "4173", "type": "CID", "arg1_id": "4158", "arg2_id": "4167", "normalized": [] }, { "id": "4174", "type": "CID", "arg1_id": "4160", "arg2_id": "4159", "normalized": [] }, { "id": "4175", "type": "CID", "arg1_id": "4160", "arg2_id": "4161", "normalized": [] }, { "id": "4176", "type": "CID", "arg1_id": "4160", "arg2_id": "4162", "normalized": [] }, { "id": "4177", "type": "CID", "arg1_id": "4160", "arg2_id": "4163", "normalized": [] }, { "id": "4178", "type": "CID", "arg1_id": "4160", "arg2_id": "4165", "normalized": [] }, { "id": "4179", "type": "CID", "arg1_id": "4160", "arg2_id": "4167", "normalized": [] }, { "id": "4180", "type": "CID", "arg1_id": "4164", "arg2_id": "4159", "normalized": [] }, { "id": "4181", "type": "CID", "arg1_id": "4164", "arg2_id": "4161", "normalized": [] }, { "id": "4182", "type": "CID", "arg1_id": "4164", "arg2_id": "4162", "normalized": [] }, { "id": "4183", "type": "CID", "arg1_id": "4164", "arg2_id": "4163", "normalized": [] }, { "id": "4184", "type": "CID", "arg1_id": "4164", "arg2_id": "4165", "normalized": [] }, { "id": "4185", "type": "CID", "arg1_id": "4164", "arg2_id": "4167", "normalized": [] } ]

[ { "id": "4187", "type": "title", "text": [ "Protective effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats." ], "offsets": [ [ 0, 92 ] ] }, { "id": "4188", "type": "abstract", "text": [ "Studies concerning with pathogenesis of gastric hemorrhage and mucosal ulceration produced in atherosclerotic rats are lacking. The aim of this study is to examine the role of gastric acid back-diffusion, mast cell histamine release, lipid peroxide (LPO) generation and mucosal microvascular permeability in modulating gastric hemorrhage and ulcer in rats with atherosclerosis induced by coadministration of vitamin D2 and cholesterol. Additionally, the protective effect of verapamil on this ulcer model was evaluated. Male Wistar rats were challenged intragastrically once daily for 9 days with 1.0 ml/kg of corn oil containing vitamin D2 and cholesterol to induce atherosclerosis. Control rats received corn oil only. After gastric surgery, rat stomachs were irrigated for 3 h with either simulated gastric juice or normal saline. Gastric acid back-diffusion, mucosal LPO generation, histamine concentration, microvascular permeability, luminal hemoglobin content and ulcer areas were determined. Elevated atherosclerotic parameters, such as serum calcium, total cholesterol and low-density lipoprotein concentration were obtained in atherosclerotic rats. Severe gastric ulcers accompanied with increased ulcerogenic factors, including gastric acid back-diffusion, histamine release, LPO generation and luminal hemoglobin content were also observed in these rats. Moreover, a positive correlation of histamine to gastric hemorrhage and to ulcer was found in those atherosclerotic rats. This hemorrhagic ulcer and various ulcerogenic parameters were dose-dependently ameliorated by daily intragastric verapamil. Atherosclerosis could produce gastric hemorrhagic ulcer via aggravation of gastric acid back-diffusion, LPO generation, histamine release and microvascular permeability that could be ameliorated by verapamil in rats." ], "offsets": [ [ 93, 1923 ] ] } ]

[ { "id": "4189", "type": "Chemical", "text": [ "verapamil" ], "offsets": [ [ 21, 30 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014700" } ] }, { "id": "4190", "type": "Disease", "text": [ "gastric hemorrhagic" ], "offsets": [ [ 34, 53 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006471" } ] }, { "id": "4191", "type": "Disease", "text": [ "ulcers" ], "offsets": [ [ 54, 60 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014456" } ] }, { "id": "4192", "type": "Disease", "text": [ "atherosclerotic" ], "offsets": [ [ 71, 86 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "4193", "type": "Disease", "text": [ "gastric hemorrhage" ], "offsets": [ [ 133, 151 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006471" } ] }, { "id": "4194", "type": "Disease", "text": [ "atherosclerotic" ], "offsets": [ [ 187, 202 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "4195", "type": "Chemical", "text": [ "histamine" ], "offsets": [ [ 308, 317 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006632" } ] }, { "id": "4196", "type": "Disease", "text": [ "gastric hemorrhage" ], "offsets": [ [ 412, 430 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006471" } ] }, { "id": "4197", "type": "Disease", "text": [ "ulcer" ], "offsets": [ [ 435, 440 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014456" } ] }, { "id": "4198", "type": "Disease", "text": [ "atherosclerosis" ], "offsets": [ [ 454, 469 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "4199", "type": "Chemical", "text": [ "vitamin D2" ], "offsets": [ [ 501, 511 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004872" } ] }, { "id": "4200", "type": "Chemical", "text": [ "cholesterol" ], "offsets": [ [ 516, 527 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002784" } ] }, { "id": "4201", "type": "Chemical", "text": [ "verapamil" ], "offsets": [ [ 568, 577 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014700" } ] }, { "id": "4202", "type": "Disease", "text": [ "ulcer" ], "offsets": [ [ 586, 591 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014456" } ] }, { "id": "4203", "type": "Chemical", "text": [ "vitamin D2" ], "offsets": [ [ 723, 733 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004872" } ] }, { "id": "4204", "type": "Chemical", "text": [ "cholesterol" ], "offsets": [ [ 738, 749 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002784" } ] }, { "id": "4205", "type": "Disease", "text": [ "atherosclerosis" ], "offsets": [ [ 760, 775 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "4206", "type": "Chemical", "text": [ "histamine" ], "offsets": [ [ 980, 989 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006632" } ] }, { "id": "4207", "type": "Chemical", "text": [ "luminal" ], "offsets": [ [ 1033, 1040 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010634" } ] }, { "id": "4208", "type": "Disease", "text": [ "ulcer" ], "offsets": [ [ 1064, 1069 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014456" } ] }, { "id": "4209", "type": "Disease", "text": [ "atherosclerotic" ], "offsets": [ [ 1102, 1117 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "4210", "type": "Chemical", "text": [ "calcium" ], "offsets": [ [ 1144, 1151 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002118" } ] }, { "id": "4211", "type": "Chemical", "text": [ "cholesterol" ], "offsets": [ [ 1159, 1170 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002784" } ] }, { "id": "4212", "type": "Disease", "text": [ "atherosclerotic" ], "offsets": [ [ 1230, 1245 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "4213", "type": "Disease", "text": [ "ulcers" ], "offsets": [ [ 1267, 1273 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014456" } ] }, { "id": "4214", "type": "Chemical", "text": [ "histamine" ], "offsets": [ [ 1361, 1370 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006632" } ] }, { "id": "4215", "type": "Chemical", "text": [ "luminal" ], "offsets": [ [ 1399, 1406 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010634" } ] }, { "id": "4216", "type": "Chemical", "text": [ "histamine" ], "offsets": [ [ 1496, 1505 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006632" } ] }, { "id": "4217", "type": "Disease", "text": [ "gastric hemorrhage" ], "offsets": [ [ 1509, 1527 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006471" } ] }, { "id": "4218", "type": "Disease", "text": [ "ulcer" ], "offsets": [ [ 1535, 1540 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014456" } ] }, { "id": "4219", "type": "Disease", "text": [ "atherosclerotic" ], "offsets": [ [ 1560, 1575 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "4220", "type": "Disease", "text": [ "hemorrhagic" ], "offsets": [ [ 1587, 1598 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006471" } ] }, { "id": "4221", "type": "Disease", "text": [ "ulcer" ], "offsets": [ [ 1599, 1604 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014456" } ] }, { "id": "4222", "type": "Chemical", "text": [ "verapamil" ], "offsets": [ [ 1696, 1705 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014700" } ] }, { "id": "4223", "type": "Disease", "text": [ "Atherosclerosis" ], "offsets": [ [ 1707, 1722 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "4224", "type": "Disease", "text": [ "gastric hemorrhagic" ], "offsets": [ [ 1737, 1756 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006471" } ] }, { "id": "4225", "type": "Disease", "text": [ "ulcer" ], "offsets": [ [ 1757, 1762 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014456" } ] }, { "id": "4226", "type": "Chemical", "text": [ "histamine" ], "offsets": [ [ 1827, 1836 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006632" } ] }, { "id": "4227", "type": "Chemical", "text": [ "verapamil" ], "offsets": [ [ 1905, 1914 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014700" } ] } ]

[]

[]

[ { "id": "4228", "type": "CID", "arg1_id": "4199", "arg2_id": "4190", "normalized": [] }, { "id": "4229", "type": "CID", "arg1_id": "4199", "arg2_id": "4193", "normalized": [] }, { "id": "4230", "type": "CID", "arg1_id": "4199", "arg2_id": "4196", "normalized": [] }, { "id": "4231", "type": "CID", "arg1_id": "4199", "arg2_id": "4217", "normalized": [] }, { "id": "4232", "type": "CID", "arg1_id": "4199", "arg2_id": "4220", "normalized": [] }, { "id": "4233", "type": "CID", "arg1_id": "4199", "arg2_id": "4224", "normalized": [] }, { "id": "4234", "type": "CID", "arg1_id": "4203", "arg2_id": "4190", "normalized": [] }, { "id": "4235", "type": "CID", "arg1_id": "4203", "arg2_id": "4193", "normalized": [] }, { "id": "4236", "type": "CID", "arg1_id": "4203", "arg2_id": "4196", "normalized": [] }, { "id": "4237", "type": "CID", "arg1_id": "4203", "arg2_id": "4217", "normalized": [] }, { "id": "4238", "type": "CID", "arg1_id": "4203", "arg2_id": "4220", "normalized": [] }, { "id": "4239", "type": "CID", "arg1_id": "4203", "arg2_id": "4224", "normalized": [] }, { "id": "4240", "type": "CID", "arg1_id": "4199", "arg2_id": "4192", "normalized": [] }, { "id": "4241", "type": "CID", "arg1_id": "4199", "arg2_id": "4194", "normalized": [] }, { "id": "4242", "type": "CID", "arg1_id": "4199", "arg2_id": "4198", "normalized": [] }, { "id": "4243", "type": "CID", "arg1_id": "4199", "arg2_id": "4205", "normalized": [] }, { "id": "4244", "type": "CID", "arg1_id": "4199", "arg2_id": "4209", "normalized": [] }, { "id": "4245", "type": "CID", "arg1_id": "4199", "arg2_id": "4212", "normalized": [] }, { "id": "4246", "type": "CID", "arg1_id": "4199", "arg2_id": "4219", "normalized": [] }, { "id": "4247", "type": "CID", "arg1_id": "4199", "arg2_id": "4223", "normalized": [] }, { "id": "4248", "type": "CID", "arg1_id": "4203", "arg2_id": "4192", "normalized": [] }, { "id": "4249", "type": "CID", "arg1_id": "4203", "arg2_id": "4194", "normalized": [] }, { "id": "4250", "type": "CID", "arg1_id": "4203", "arg2_id": "4198", "normalized": [] }, { "id": "4251", "type": "CID", "arg1_id": "4203", "arg2_id": "4205", "normalized": [] }, { "id": "4252", "type": "CID", "arg1_id": "4203", "arg2_id": "4209", "normalized": [] }, { "id": "4253", "type": "CID", "arg1_id": "4203", "arg2_id": "4212", "normalized": [] }, { "id": "4254", "type": "CID", "arg1_id": "4203", "arg2_id": "4219", "normalized": [] }, { "id": "4255", "type": "CID", "arg1_id": "4203", "arg2_id": "4223", "normalized": [] }, { "id": "4256", "type": "CID", "arg1_id": "4200", "arg2_id": "4190", "normalized": [] }, { "id": "4257", "type": "CID", "arg1_id": "4200", "arg2_id": "4193", "normalized": [] }, { "id": "4258", "type": "CID", "arg1_id": "4200", "arg2_id": "4196", "normalized": [] }, { "id": "4259", "type": "CID", "arg1_id": "4200", "arg2_id": "4217", "normalized": [] }, { "id": "4260", "type": "CID", "arg1_id": "4200", "arg2_id": "4220", "normalized": [] }, { "id": "4261", "type": "CID", "arg1_id": "4200", "arg2_id": "4224", "normalized": [] }, { "id": "4262", "type": "CID", "arg1_id": "4204", "arg2_id": "4190", "normalized": [] }, { "id": "4263", "type": "CID", "arg1_id": "4204", "arg2_id": "4193", "normalized": [] }, { "id": "4264", "type": "CID", "arg1_id": "4204", "arg2_id": "4196", "normalized": [] }, { "id": "4265", "type": "CID", "arg1_id": "4204", "arg2_id": "4217", "normalized": [] }, { "id": "4266", "type": "CID", "arg1_id": "4204", "arg2_id": "4220", "normalized": [] }, { "id": "4267", "type": "CID", "arg1_id": "4204", "arg2_id": "4224", "normalized": [] }, { "id": "4268", "type": "CID", "arg1_id": "4211", "arg2_id": "4190", "normalized": [] }, { "id": "4269", "type": "CID", "arg1_id": "4211", "arg2_id": "4193", "normalized": [] }, { "id": "4270", "type": "CID", "arg1_id": "4211", "arg2_id": "4196", "normalized": [] }, { "id": "4271", "type": "CID", "arg1_id": "4211", "arg2_id": "4217", "normalized": [] }, { "id": "4272", "type": "CID", "arg1_id": "4211", "arg2_id": "4220", "normalized": [] }, { "id": "4273", "type": "CID", "arg1_id": "4211", "arg2_id": "4224", "normalized": [] }, { "id": "4274", "type": "CID", "arg1_id": "4200", "arg2_id": "4191", "normalized": [] }, { "id": "4275", "type": "CID", "arg1_id": "4200", "arg2_id": "4197", "normalized": [] }, { "id": "4276", "type": "CID", "arg1_id": "4200", "arg2_id": "4202", "normalized": [] }, { "id": "4277", "type": "CID", "arg1_id": "4200", "arg2_id": "4208", "normalized": [] }, { "id": "4278", "type": "CID", "arg1_id": "4200", "arg2_id": "4213", "normalized": [] }, { "id": "4279", "type": "CID", "arg1_id": "4200", "arg2_id": "4218", "normalized": [] }, { "id": "4280", "type": "CID", "arg1_id": "4200", "arg2_id": "4221", "normalized": [] }, { "id": "4281", "type": "CID", "arg1_id": "4200", "arg2_id": "4225", "normalized": [] }, { "id": "4282", "type": "CID", "arg1_id": "4204", "arg2_id": "4191", "normalized": [] }, { "id": "4283", "type": "CID", "arg1_id": "4204", "arg2_id": "4197", "normalized": [] }, { "id": "4284", "type": "CID", "arg1_id": "4204", "arg2_id": "4202", "normalized": [] }, { "id": "4285", "type": "CID", "arg1_id": "4204", "arg2_id": "4208", "normalized": [] }, { "id": "4286", "type": "CID", "arg1_id": "4204", "arg2_id": "4213", "normalized": [] }, { "id": "4287", "type": "CID", "arg1_id": "4204", "arg2_id": "4218", "normalized": [] }, { "id": "4288", "type": "CID", "arg1_id": "4204", "arg2_id": "4221", "normalized": [] }, { "id": "4289", "type": "CID", "arg1_id": "4204", "arg2_id": "4225", "normalized": [] }, { "id": "4290", "type": "CID", "arg1_id": "4211", "arg2_id": "4191", "normalized": [] }, { "id": "4291", "type": "CID", "arg1_id": "4211", "arg2_id": "4197", "normalized": [] }, { "id": "4292", "type": "CID", "arg1_id": "4211", "arg2_id": "4202", "normalized": [] }, { "id": "4293", "type": "CID", "arg1_id": "4211", "arg2_id": "4208", "normalized": [] }, { "id": "4294", "type": "CID", "arg1_id": "4211", "arg2_id": "4213", "normalized": [] }, { "id": "4295", "type": "CID", "arg1_id": "4211", "arg2_id": "4218", "normalized": [] }, { "id": "4296", "type": "CID", "arg1_id": "4211", "arg2_id": "4221", "normalized": [] }, { "id": "4297", "type": "CID", "arg1_id": "4211", "arg2_id": "4225", "normalized": [] }, { "id": "4298", "type": "CID", "arg1_id": "4200", "arg2_id": "4192", "normalized": [] }, { "id": "4299", "type": "CID", "arg1_id": "4200", "arg2_id": "4194", "normalized": [] }, { "id": "4300", "type": "CID", "arg1_id": "4200", "arg2_id": "4198", "normalized": [] }, { "id": "4301", "type": "CID", "arg1_id": "4200", "arg2_id": "4205", "normalized": [] }, { "id": "4302", "type": "CID", "arg1_id": "4200", "arg2_id": "4209", "normalized": [] }, { "id": "4303", "type": "CID", "arg1_id": "4200", "arg2_id": "4212", "normalized": [] }, { "id": "4304", "type": "CID", "arg1_id": "4200", "arg2_id": "4219", "normalized": [] }, { "id": "4305", "type": "CID", "arg1_id": "4200", "arg2_id": "4223", "normalized": [] }, { "id": "4306", "type": "CID", "arg1_id": "4204", "arg2_id": "4192", "normalized": [] }, { "id": "4307", "type": "CID", "arg1_id": "4204", "arg2_id": "4194", "normalized": [] }, { "id": "4308", "type": "CID", "arg1_id": "4204", "arg2_id": "4198", "normalized": [] }, { "id": "4309", "type": "CID", "arg1_id": "4204", "arg2_id": "4205", "normalized": [] }, { "id": "4310", "type": "CID", "arg1_id": "4204", "arg2_id": "4209", "normalized": [] }, { "id": "4311", "type": "CID", "arg1_id": "4204", "arg2_id": "4212", "normalized": [] }, { "id": "4312", "type": "CID", "arg1_id": "4204", "arg2_id": "4219", "normalized": [] }, { "id": "4313", "type": "CID", "arg1_id": "4204", "arg2_id": "4223", "normalized": [] }, { "id": "4314", "type": "CID", "arg1_id": "4211", "arg2_id": "4192", "normalized": [] }, { "id": "4315", "type": "CID", "arg1_id": "4211", "arg2_id": "4194", "normalized": [] }, { "id": "4316", "type": "CID", "arg1_id": "4211", "arg2_id": "4198", "normalized": [] }, { "id": "4317", "type": "CID", "arg1_id": "4211", "arg2_id": "4205", "normalized": [] }, { "id": "4318", "type": "CID", "arg1_id": "4211", "arg2_id": "4209", "normalized": [] }, { "id": "4319", "type": "CID", "arg1_id": "4211", "arg2_id": "4212", "normalized": [] }, { "id": "4320", "type": "CID", "arg1_id": "4211", "arg2_id": "4219", "normalized": [] }, { "id": "4321", "type": "CID", "arg1_id": "4211", "arg2_id": "4223", "normalized": [] }, { "id": "4322", "type": "CID", "arg1_id": "4199", "arg2_id": "4191", "normalized": [] }, { "id": "4323", "type": "CID", "arg1_id": "4199", "arg2_id": "4197", "normalized": [] }, { "id": "4324", "type": "CID", "arg1_id": "4199", "arg2_id": "4202", "normalized": [] }, { "id": "4325", "type": "CID", "arg1_id": "4199", "arg2_id": "4208", "normalized": [] }, { "id": "4326", "type": "CID", "arg1_id": "4199", "arg2_id": "4213", "normalized": [] }, { "id": "4327", "type": "CID", "arg1_id": "4199", "arg2_id": "4218", "normalized": [] }, { "id": "4328", "type": "CID", "arg1_id": "4199", "arg2_id": "4221", "normalized": [] }, { "id": "4329", "type": "CID", "arg1_id": "4199", "arg2_id": "4225", "normalized": [] }, { "id": "4330", "type": "CID", "arg1_id": "4203", "arg2_id": "4191", "normalized": [] }, { "id": "4331", "type": "CID", "arg1_id": "4203", "arg2_id": "4197", "normalized": [] }, { "id": "4332", "type": "CID", "arg1_id": "4203", "arg2_id": "4202", "normalized": [] }, { "id": "4333", "type": "CID", "arg1_id": "4203", "arg2_id": "4208", "normalized": [] }, { "id": "4334", "type": "CID", "arg1_id": "4203", "arg2_id": "4213", "normalized": [] }, { "id": "4335", "type": "CID", "arg1_id": "4203", "arg2_id": "4218", "normalized": [] }, { "id": "4336", "type": "CID", "arg1_id": "4203", "arg2_id": "4221", "normalized": [] }, { "id": "4337", "type": "CID", "arg1_id": "4203", "arg2_id": "4225", "normalized": [] } ]

[ { "id": "4339", "type": "title", "text": [ "Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure." ], "offsets": [ [ 0, 106 ] ] }, { "id": "4340", "type": "abstract", "text": [ "BACKGROUND: The mechanisms underlying heart failure induced by adriamycin are very complicated and still unclear. The aim of this study was to investigate whether autophagy was involved in the progression of heart failure induced by adriamycin, so that we can develop a novel treatment strategy for heart failure. METHODS: 3-methyladenine (3MA), a specific inhibitor on autophagy was used in a heart failure model of rats induced by adriamycin. Neonatal cardiomyocytes were isolated from Sprague-Dawley rat hearts and randomly divided into controls, an adriamycin-treated group, and a 3MA plus adriamycin-treated group. We then examined the morphology, expression of beclin 1 gene, mitochondrial permeability transition (MPT), and Na+-K+ ATPase activity in vivo. We also assessed cell viability, mitochondrial membrane potential changes and counted autophagic vacuoles in cultured cardiomyocytes. In addition, we analyzed the expression of autophagy associated gene, beclin 1 using RT-PCR and Western blotting in an animal model. RESULTS: 3MA significantly improved cardiac function and reduced mitochondrial injury. Furthermore, adriamycin induced the formation of autophagic vacuoles, and 3MA strongly downregulated the expression of beclin 1 in adriamycin-induced failing heart and inhibited the formation of autophagic vacuoles. CONCLUSION: Autophagic cardiomyocyte death plays an important role in the pathogenesis of heart failure in rats induced by adriamycin. Mitochondrial injury may be involved in the progression of heart failure caused by adriamycin via the autophagy pathway." ], "offsets": [ [ 107, 1695 ] ] } ]

[ { "id": "4341", "type": "Chemical", "text": [ "Adriamycin" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4342", "type": "Disease", "text": [ "death" ], "offsets": [ [ 44, 49 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003643" } ] }, { "id": "4343", "type": "Disease", "text": [ "heart failure" ], "offsets": [ [ 92, 105 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006333" } ] }, { "id": "4344", "type": "Disease", "text": [ "heart failure" ], "offsets": [ [ 145, 158 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006333" } ] }, { "id": "4345", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 170, 180 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4346", "type": "Disease", "text": [ "heart failure" ], "offsets": [ [ 315, 328 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006333" } ] }, { "id": "4347", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 340, 350 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4348", "type": "Disease", "text": [ "heart failure" ], "offsets": [ [ 406, 419 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006333" } ] }, { "id": "4349", "type": "Chemical", "text": [ "3-methyladenine" ], "offsets": [ [ 430, 445 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C025946" } ] }, { "id": "4350", "type": "Chemical", "text": [ "3MA" ], "offsets": [ [ 447, 450 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C025946" } ] }, { "id": "4351", "type": "Disease", "text": [ "heart failure" ], "offsets": [ [ 501, 514 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006333" } ] }, { "id": "4352", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 540, 550 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4353", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 660, 670 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4354", "type": "Chemical", "text": [ "3MA" ], "offsets": [ [ 692, 695 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C025946" } ] }, { "id": "4355", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 701, 711 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4356", "type": "Chemical", "text": [ "K" ], "offsets": [ [ 842, 843 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011188" } ] }, { "id": "4357", "type": "Chemical", "text": [ "3MA" ], "offsets": [ [ 1146, 1149 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C025946" } ] }, { "id": "4358", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 1237, 1247 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4359", "type": "Chemical", "text": [ "3MA" ], "offsets": [ [ 1298, 1301 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C025946" } ] }, { "id": "4360", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 1355, 1365 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4361", "type": "Disease", "text": [ "death" ], "offsets": [ [ 1477, 1482 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003643" } ] }, { "id": "4362", "type": "Disease", "text": [ "heart failure" ], "offsets": [ [ 1530, 1543 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006333" } ] }, { "id": "4363", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 1563, 1573 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "4364", "type": "Disease", "text": [ "heart failure" ], "offsets": [ [ 1634, 1647 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006333" } ] }, { "id": "4365", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 1658, 1668 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] } ]

[]

[]

[ { "id": "4366", "type": "CID", "arg1_id": "4341", "arg2_id": "4343", "normalized": [] }, { "id": "4367", "type": "CID", "arg1_id": "4341", "arg2_id": "4344", "normalized": [] }, { "id": "4368", "type": "CID", "arg1_id": "4341", "arg2_id": "4346", "normalized": [] }, { "id": "4369", "type": "CID", "arg1_id": "4341", "arg2_id": "4348", "normalized": [] }, { "id": "4370", "type": "CID", "arg1_id": "4341", "arg2_id": "4351", "normalized": [] }, { "id": "4371", "type": "CID", "arg1_id": "4341", "arg2_id": "4362", "normalized": [] }, { "id": "4372", "type": "CID", "arg1_id": "4341", "arg2_id": "4364", "normalized": [] }, { "id": "4373", "type": "CID", "arg1_id": "4345", "arg2_id": "4343", "normalized": [] }, { "id": "4374", "type": "CID", "arg1_id": "4345", "arg2_id": "4344", "normalized": [] }, { "id": "4375", "type": "CID", "arg1_id": "4345", "arg2_id": "4346", "normalized": [] }, { "id": "4376", "type": "CID", "arg1_id": "4345", "arg2_id": "4348", "normalized": [] }, { "id": "4377", "type": "CID", "arg1_id": "4345", "arg2_id": "4351", "normalized": [] }, { "id": "4378", "type": "CID", "arg1_id": "4345", "arg2_id": "4362", "normalized": [] }, { "id": "4379", "type": "CID", "arg1_id": "4345", "arg2_id": "4364", "normalized": [] }, { "id": "4380", "type": "CID", "arg1_id": "4347", "arg2_id": "4343", "normalized": [] }, { "id": "4381", "type": "CID", "arg1_id": "4347", "arg2_id": "4344", "normalized": [] }, { "id": "4382", "type": "CID", "arg1_id": "4347", "arg2_id": "4346", "normalized": [] }, { "id": "4383", "type": "CID", "arg1_id": "4347", "arg2_id": "4348", "normalized": [] }, { "id": "4384", "type": "CID", "arg1_id": "4347", "arg2_id": "4351", "normalized": [] }, { "id": "4385", "type": "CID", "arg1_id": "4347", "arg2_id": "4362", "normalized": [] }, { "id": "4386", "type": "CID", "arg1_id": "4347", "arg2_id": "4364", "normalized": [] }, { "id": "4387", "type": "CID", "arg1_id": "4352", "arg2_id": "4343", "normalized": [] }, { "id": "4388", "type": "CID", "arg1_id": "4352", "arg2_id": "4344", "normalized": [] }, { "id": "4389", "type": "CID", "arg1_id": "4352", "arg2_id": "4346", "normalized": [] }, { "id": "4390", "type": "CID", "arg1_id": "4352", "arg2_id": "4348", "normalized": [] }, { "id": "4391", "type": "CID", "arg1_id": "4352", "arg2_id": "4351", "normalized": [] }, { "id": "4392", "type": "CID", "arg1_id": "4352", "arg2_id": "4362", "normalized": [] }, { "id": "4393", "type": "CID", "arg1_id": "4352", "arg2_id": "4364", "normalized": [] }, { "id": "4394", "type": "CID", "arg1_id": "4353", "arg2_id": "4343", "normalized": [] }, { "id": "4395", "type": "CID", "arg1_id": "4353", "arg2_id": "4344", "normalized": [] }, { "id": "4396", "type": "CID", "arg1_id": "4353", "arg2_id": "4346", "normalized": [] }, { "id": "4397", "type": "CID", "arg1_id": "4353", "arg2_id": "4348", "normalized": [] }, { "id": "4398", "type": "CID", "arg1_id": "4353", "arg2_id": "4351", "normalized": [] }, { "id": "4399", "type": "CID", "arg1_id": "4353", "arg2_id": "4362", "normalized": [] }, { "id": "4400", "type": "CID", "arg1_id": "4353", "arg2_id": "4364", "normalized": [] }, { "id": "4401", "type": "CID", "arg1_id": "4355", "arg2_id": "4343", "normalized": [] }, { "id": "4402", "type": "CID", "arg1_id": "4355", "arg2_id": "4344", "normalized": [] }, { "id": "4403", "type": "CID", "arg1_id": "4355", "arg2_id": "4346", "normalized": [] }, { "id": "4404", "type": "CID", "arg1_id": "4355", "arg2_id": "4348", "normalized": [] }, { "id": "4405", "type": "CID", "arg1_id": "4355", "arg2_id": "4351", "normalized": [] }, { "id": "4406", "type": "CID", "arg1_id": "4355", "arg2_id": "4362", "normalized": [] }, { "id": "4407", "type": "CID", "arg1_id": "4355", "arg2_id": "4364", "normalized": [] }, { "id": "4408", "type": "CID", "arg1_id": "4358", "arg2_id": "4343", "normalized": [] }, { "id": "4409", "type": "CID", "arg1_id": "4358", "arg2_id": "4344", "normalized": [] }, { "id": "4410", "type": "CID", "arg1_id": "4358", "arg2_id": "4346", "normalized": [] }, { "id": "4411", "type": "CID", "arg1_id": "4358", "arg2_id": "4348", "normalized": [] }, { "id": "4412", "type": "CID", "arg1_id": "4358", "arg2_id": "4351", "normalized": [] }, { "id": "4413", "type": "CID", "arg1_id": "4358", "arg2_id": "4362", "normalized": [] }, { "id": "4414", "type": "CID", "arg1_id": "4358", "arg2_id": "4364", "normalized": [] }, { "id": "4415", "type": "CID", "arg1_id": "4360", "arg2_id": "4343", "normalized": [] }, { "id": "4416", "type": "CID", "arg1_id": "4360", "arg2_id": "4344", "normalized": [] }, { "id": "4417", "type": "CID", "arg1_id": "4360", "arg2_id": "4346", "normalized": [] }, { "id": "4418", "type": "CID", "arg1_id": "4360", "arg2_id": "4348", "normalized": [] }, { "id": "4419", "type": "CID", "arg1_id": "4360", "arg2_id": "4351", "normalized": [] }, { "id": "4420", "type": "CID", "arg1_id": "4360", "arg2_id": "4362", "normalized": [] }, { "id": "4421", "type": "CID", "arg1_id": "4360", "arg2_id": "4364", "normalized": [] }, { "id": "4422", "type": "CID", "arg1_id": "4363", "arg2_id": "4343", "normalized": [] }, { "id": "4423", "type": "CID", "arg1_id": "4363", "arg2_id": "4344", "normalized": [] }, { "id": "4424", "type": "CID", "arg1_id": "4363", "arg2_id": "4346", "normalized": [] }, { "id": "4425", "type": "CID", "arg1_id": "4363", "arg2_id": "4348", "normalized": [] }, { "id": "4426", "type": "CID", "arg1_id": "4363", "arg2_id": "4351", "normalized": [] }, { "id": "4427", "type": "CID", "arg1_id": "4363", "arg2_id": "4362", "normalized": [] }, { "id": "4428", "type": "CID", "arg1_id": "4363", "arg2_id": "4364", "normalized": [] }, { "id": "4429", "type": "CID", "arg1_id": "4365", "arg2_id": "4343", "normalized": [] }, { "id": "4430", "type": "CID", "arg1_id": "4365", "arg2_id": "4344", "normalized": [] }, { "id": "4431", "type": "CID", "arg1_id": "4365", "arg2_id": "4346", "normalized": [] }, { "id": "4432", "type": "CID", "arg1_id": "4365", "arg2_id": "4348", "normalized": [] }, { "id": "4433", "type": "CID", "arg1_id": "4365", "arg2_id": "4351", "normalized": [] }, { "id": "4434", "type": "CID", "arg1_id": "4365", "arg2_id": "4362", "normalized": [] }, { "id": "4435", "type": "CID", "arg1_id": "4365", "arg2_id": "4364", "normalized": [] } ]

[ { "id": "4437", "type": "title", "text": [ "Confusion, a rather serious adverse drug reaction with valproic acid: a review of the French Pharmacovigilance database." ], "offsets": [ [ 0, 120 ] ] }, { "id": "4438", "type": "abstract", "text": [ "INTRODUCTION: Confusion is an adverse drug reaction frequently observed with valproic acid. Some case reports are published in the literature but no systematic study from a sample of patients has been published. We performed this study in order to describe the main characteristics of this adverse drug reaction. METHODS: Using the French Pharmacovigilance database, we selected the cases of confusion reported since 1985 with valproic acid. RESULTS: 272 cases of confusion were reported with valproic acid: 153 women and 119 men. Confusion mostly occurred during the two first weeks following valproic acid exposure (39.7%). It was \"serious\" for almost 2/3 of the patients (62.5%) and its outcome favourable in most of the cases (82%). The occurrence of this ADR was more frequent in patients aged between 61 and 80 years. CONCLUSION: This work shows that confusion with valproic acid is a serious, rather frequent but reversible adverse drug reaction. It occurs especially in older patients and during the first two weeks of treatment." ], "offsets": [ [ 121, 1158 ] ] } ]

[ { "id": "4439", "type": "Disease", "text": [ "Confusion" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003221" } ] }, { "id": "4440", "type": "Chemical", "text": [ "valproic acid" ], "offsets": [ [ 55, 68 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014635" } ] }, { "id": "4441", "type": "Disease", "text": [ "Confusion" ], "offsets": [ [ 135, 144 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003221" } ] }, { "id": "4442", "type": "Chemical", "text": [ "valproic acid" ], "offsets": [ [ 198, 211 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014635" } ] }, { "id": "4443", "type": "Disease", "text": [ "confusion" ], "offsets": [ [ 513, 522 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003221" } ] }, { "id": "4444", "type": "Chemical", "text": [ "valproic acid" ], "offsets": [ [ 548, 561 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014635" } ] }, { "id": "4445", "type": "Disease", "text": [ "confusion" ], "offsets": [ [ 585, 594 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003221" } ] }, { "id": "4446", "type": "Chemical", "text": [ "valproic acid" ], "offsets": [ [ 614, 627 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014635" } ] }, { "id": "4447", "type": "Disease", "text": [ "Confusion" ], "offsets": [ [ 652, 661 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003221" } ] }, { "id": "4448", "type": "Chemical", "text": [ "valproic acid" ], "offsets": [ [ 715, 728 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014635" } ] }, { "id": "4449", "type": "Disease", "text": [ "confusion" ], "offsets": [ [ 978, 987 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003221" } ] }, { "id": "4450", "type": "Chemical", "text": [ "valproic acid" ], "offsets": [ [ 993, 1006 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014635" } ] } ]

[]

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[ { "id": "4488", "type": "title", "text": [ "Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task." ], "offsets": [ [ 0, 102 ] ] }, { "id": "4489", "type": "abstract", "text": [ "It has been consistently shown that ecstasy users display impairments in learning and memory performance. In addition, working memory processing in ecstasy users has been shown to be associated with neural alterations in hippocampal and/or cortical regions as measured by functional magnetic resonance imaging (fMRI). Using functional imaging and a face-learning task, we investigated neural correlates of encoding and recalling face-name associations in 20 recreational drug users whose predominant drug use was ecstasy and 20 controls. To address the potential confounding effects of the cannabis use of the ecstasy using group, a second analysis included 14 previously tested cannabis users (Nestor, L., Roberts, G., Garavan, H., Hester, R., 2008. Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users. Neuroimage 40, 1328-1339). Ecstasy users performed significantly worse in learning and memory compared to controls and cannabis users. A conjunction analysis of the encode and recall phases of the task revealed ecstasy-specific hyperactivity in bilateral frontal regions, left temporal, right parietal, bilateral temporal, and bilateral occipital brain regions. Ecstasy-specific hypoactivity was evident in the right dorsal anterior cingulated cortex (ACC) and left posterior cingulated cortex. In both ecstasy and cannabis groups brain activation was decreased in the right medial frontal gyrus, left parahippocampal gyrus, left dorsal cingulate gyrus, and left caudate. These results elucidated ecstasy-related deficits, only some of which might be attributed to cannabis use. These ecstasy-specific effects may be related to the vulnerability of isocortical and allocortical regions to the neurotoxic effects of ecstasy." ], "offsets": [ [ 103, 1891 ] ] } ]

[ { "id": "4490", "type": "Disease", "text": [ "Learning and memory deficits" ], "offsets": [ [ 0, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007859" }, { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "4491", "type": "Disease", "text": [ "Learning", "deficits" ], "offsets": [ [ 0, 8 ], [ 20, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007859" } ] }, { "id": "4492", "type": "Disease", "text": [ "memory deficits" ], "offsets": [ [ 13, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "4493", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 32, 39 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4494", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 139, 146 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4495", "type": "Disease", "text": [ "impairments in learning and memory" ], "offsets": [ [ 161, 195 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007859" }, { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "4496", "type": "Disease", "text": [ "impairments in learning" ], "offsets": [ [ 161, 184 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007859" } ] }, { "id": "4497", "type": "Disease", "text": [ "impairments in", "memory" ], "offsets": [ [ 161, 175 ], [ 189, 195 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "4498", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 251, 258 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4499", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 616, 623 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4500", "type": "Chemical", "text": [ "cannabis" ], "offsets": [ [ 693, 701 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002188" } ] }, { "id": "4501", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 713, 720 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4502", "type": "Chemical", "text": [ "cannabis" ], "offsets": [ [ 782, 790 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002188" } ] }, { "id": "4503", "type": "Disease", "text": [ "Deficits in learning and memory" ], "offsets": [ [ 854, 885 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007859" }, { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "4504", "type": "Disease", "text": [ "Deficits in learning" ], "offsets": [ [ 854, 874 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007859" } ] }, { "id": "4505", "type": "Disease", "text": [ "Deficits in", "memory" ], "offsets": [ [ 854, 865 ], [ 879, 885 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008569" } ] }, { "id": "4506", "type": "Disease", "text": [ "hyperactivity" ], "offsets": [ [ 903, 916 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006948" } ] }, { "id": "4507", "type": "Chemical", "text": [ "cannabis" ], "offsets": [ [ 952, 960 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002188" } ] }, { "id": "4508", "type": "Chemical", "text": [ "Ecstasy" ], "offsets": [ [ 995, 1002 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4509", "type": "Chemical", "text": [ "cannabis" ], "offsets": [ [ 1087, 1095 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002188" } ] }, { "id": "4510", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 1179, 1186 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4511", "type": "Disease", "text": [ "hyperactivity" ], "offsets": [ [ 1196, 1209 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006948" } ] }, { "id": "4512", "type": "Chemical", "text": [ "Ecstasy" ], "offsets": [ [ 1330, 1337 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4513", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 1471, 1478 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4514", "type": "Chemical", "text": [ "cannabis" ], "offsets": [ [ 1483, 1491 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002188" } ] }, { "id": "4515", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 1665, 1672 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4516", "type": "Chemical", "text": [ "cannabis" ], "offsets": [ [ 1733, 1741 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002188" } ] }, { "id": "4517", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 1753, 1760 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] }, { "id": "4518", "type": "Disease", "text": [ "neurotoxic" ], "offsets": [ [ 1861, 1871 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020258" } ] }, { "id": "4519", "type": "Chemical", "text": [ "ecstasy" ], "offsets": [ [ 1883, 1890 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D018817" } ] } ]

[]

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"4494", "arg2_id": "4490", "normalized": [] }, { "id": "4599", "type": "CID", "arg1_id": "4494", "arg2_id": "4491", "normalized": [] }, { "id": "4600", "type": "CID", "arg1_id": "4494", "arg2_id": "4495", "normalized": [] }, { "id": "4601", "type": "CID", "arg1_id": "4494", "arg2_id": "4496", "normalized": [] }, { "id": "4602", "type": "CID", "arg1_id": "4494", "arg2_id": "4503", "normalized": [] }, { "id": "4603", "type": "CID", "arg1_id": "4494", "arg2_id": "4504", "normalized": [] }, { "id": "4604", "type": "CID", "arg1_id": "4498", "arg2_id": "4490", "normalized": [] }, { "id": "4605", "type": "CID", "arg1_id": "4498", "arg2_id": "4491", "normalized": [] }, { "id": "4606", "type": "CID", "arg1_id": "4498", "arg2_id": "4495", "normalized": [] }, { "id": "4607", "type": "CID", "arg1_id": "4498", "arg2_id": "4496", "normalized": [] }, { "id": "4608", "type": "CID", "arg1_id": "4498", "arg2_id": "4503", "normalized": [] }, { "id": "4609", "type": "CID", "arg1_id": "4498", "arg2_id": "4504", "normalized": [] }, { "id": "4610", "type": "CID", "arg1_id": "4499", "arg2_id": "4490", "normalized": [] }, { "id": "4611", "type": "CID", "arg1_id": "4499", "arg2_id": "4491", "normalized": [] }, { "id": "4612", "type": "CID", "arg1_id": "4499", "arg2_id": "4495", "normalized": [] }, { "id": "4613", "type": "CID", "arg1_id": "4499", "arg2_id": "4496", "normalized": [] }, { "id": "4614", "type": "CID", "arg1_id": "4499", "arg2_id": "4503", "normalized": [] }, { "id": "4615", "type": "CID", "arg1_id": "4499", "arg2_id": "4504", "normalized": [] }, { "id": "4616", "type": "CID", "arg1_id": "4501", "arg2_id": "4490", "normalized": [] }, { "id": "4617", "type": "CID", "arg1_id": "4501", "arg2_id": "4491", "normalized": [] }, { "id": "4618", "type": "CID", "arg1_id": "4501", "arg2_id": "4495", "normalized": [] }, { "id": "4619", "type": "CID", "arg1_id": "4501", "arg2_id": "4496", "normalized": [] }, { "id": "4620", "type": "CID", "arg1_id": "4501", "arg2_id": "4503", "normalized": [] }, { "id": "4621", "type": "CID", "arg1_id": "4501", "arg2_id": "4504", "normalized": [] }, { "id": "4622", "type": "CID", "arg1_id": "4508", "arg2_id": "4490", "normalized": [] }, { "id": "4623", "type": "CID", "arg1_id": "4508", "arg2_id": "4491", "normalized": [] }, { "id": "4624", "type": "CID", "arg1_id": "4508", "arg2_id": "4495", "normalized": [] }, { "id": "4625", "type": "CID", "arg1_id": "4508", "arg2_id": "4496", "normalized": [] }, { "id": "4626", "type": "CID", "arg1_id": "4508", "arg2_id": "4503", "normalized": [] }, { "id": "4627", "type": "CID", "arg1_id": "4508", "arg2_id": "4504", "normalized": [] }, { "id": "4628", "type": "CID", "arg1_id": "4510", "arg2_id": "4490", "normalized": [] }, { "id": "4629", "type": "CID", "arg1_id": "4510", "arg2_id": "4491", "normalized": [] }, { "id": "4630", "type": "CID", "arg1_id": "4510", "arg2_id": "4495", "normalized": [] }, { "id": "4631", "type": "CID", "arg1_id": "4510", "arg2_id": "4496", "normalized": [] }, { "id": "4632", "type": "CID", "arg1_id": "4510", "arg2_id": "4503", "normalized": [] }, { "id": "4633", "type": "CID", "arg1_id": "4510", "arg2_id": "4504", "normalized": [] }, { "id": "4634", "type": "CID", "arg1_id": "4512", "arg2_id": "4490", "normalized": [] }, { "id": "4635", "type": "CID", "arg1_id": "4512", "arg2_id": "4491", "normalized": [] }, { "id": "4636", "type": "CID", "arg1_id": "4512", "arg2_id": "4495", "normalized": [] }, { "id": "4637", "type": "CID", "arg1_id": "4512", "arg2_id": "4496", "normalized": [] }, { "id": "4638", "type": "CID", "arg1_id": "4512", "arg2_id": "4503", "normalized": [] }, { "id": "4639", "type": "CID", "arg1_id": "4512", "arg2_id": "4504", "normalized": [] }, { "id": "4640", "type": "CID", "arg1_id": "4513", "arg2_id": "4490", "normalized": [] }, { "id": "4641", "type": "CID", "arg1_id": "4513", "arg2_id": "4491", "normalized": [] }, { "id": "4642", "type": "CID", "arg1_id": "4513", "arg2_id": "4495", "normalized": [] }, { "id": "4643", "type": "CID", "arg1_id": "4513", "arg2_id": "4496", "normalized": [] }, { "id": "4644", "type": "CID", "arg1_id": "4513", "arg2_id": "4503", "normalized": [] }, { "id": "4645", "type": "CID", "arg1_id": "4513", "arg2_id": "4504", "normalized": [] }, { "id": "4646", "type": "CID", "arg1_id": "4515", "arg2_id": "4490", "normalized": [] }, { "id": "4647", "type": "CID", "arg1_id": "4515", "arg2_id": "4491", "normalized": [] }, { "id": "4648", "type": "CID", "arg1_id": "4515", "arg2_id": "4495", "normalized": [] }, { "id": "4649", "type": "CID", "arg1_id": "4515", "arg2_id": "4496", "normalized": [] }, { "id": "4650", "type": "CID", "arg1_id": "4515", "arg2_id": "4503", "normalized": [] }, { "id": "4651", "type": "CID", "arg1_id": "4515", "arg2_id": "4504", "normalized": [] }, { "id": "4652", "type": "CID", "arg1_id": "4517", "arg2_id": "4490", "normalized": [] }, { "id": "4653", "type": "CID", "arg1_id": "4517", "arg2_id": "4491", "normalized": [] }, { "id": "4654", "type": "CID", "arg1_id": "4517", "arg2_id": "4495", "normalized": [] }, { "id": "4655", "type": "CID", "arg1_id": "4517", "arg2_id": "4496", "normalized": [] }, { "id": "4656", "type": "CID", "arg1_id": "4517", "arg2_id": "4503", "normalized": [] }, { "id": "4657", "type": "CID", "arg1_id": "4517", "arg2_id": "4504", "normalized": [] }, { "id": "4658", "type": "CID", "arg1_id": "4519", "arg2_id": "4490", "normalized": [] }, { "id": "4659", "type": "CID", "arg1_id": "4519", "arg2_id": "4491", "normalized": [] }, { "id": "4660", "type": "CID", "arg1_id": "4519", "arg2_id": "4495", "normalized": [] }, { "id": "4661", "type": "CID", "arg1_id": "4519", "arg2_id": "4496", "normalized": [] }, { "id": "4662", "type": "CID", "arg1_id": "4519", "arg2_id": "4503", "normalized": [] }, { "id": "4663", "type": "CID", "arg1_id": "4519", "arg2_id": "4504", "normalized": [] } ]

[ { "id": "4665", "type": "title", "text": [ "Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis." ], "offsets": [ [ 0, 150 ] ] }, { "id": "4666", "type": "abstract", "text": [ "BACKGROUND: Direct thrombin inhibitors (DTIs) provide an alternative method of anticoagulation for patients with a history of heparin-induced thrombocytopenia (HIT) or HIT with thrombosis (HITT) undergoing cardiopulmonary bypass (CPB). In the following report, a 65-year-old critically ill patient with a suspected history of HITT was administered argatroban for anticoagulation on bypass during heart transplantation. The patient required massive transfusion support (55 units of red blood cells, 42 units of fresh-frozen plasma, 40 units of cryoprecipitate, 40 units of platelets, and three doses of recombinant Factor VIIa) for severe intraoperative and postoperative bleeding. STUDY DESIGN AND METHODS: Plasma samples from before and after CPB were analyzed postoperatively for argatroban concentration using a modified ecarin clotting time (ECT) assay. RESULTS: Unexpectedly high concentrations of argatroban were measured in these samples (range, 0-32 microg/mL), and a prolonged plasma argatroban half life (t(1/2)) of 514 minutes was observed (published elimination t(1/2) is 39-51 minutes [< or = 181 minutes with hepatic impairment]). CONCLUSIONS: Correlation of plasma argatroban concentration versus the patient's coagulation variables and clinical course suggest that prolonged elevated levels of plasma argatroban may have contributed to the patient's extended coagulopathy. Because DTIs do not have reversal agents, surgical teams and transfusion services should remain aware of the possibility of massive transfusion events during anticoagulation with these agents. This is the first report to measure plasma argatroban concentration in the context of CPB and extended coagulopathy." ], "offsets": [ [ 151, 1849 ] ] } ]

[ { "id": "4667", "type": "Chemical", "text": [ "argatroban" ], "offsets": [ [ 30, 40 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C031942" } ] }, { "id": "4668", "type": "Chemical", "text": [ "heparin" ], "offsets": [ [ 101, 108 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006493" } ] }, { "id": "4669", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 117, 133 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "4670", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 139, 149 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "4671", "type": "Chemical", "text": [ "heparin" ], "offsets": [ [ 277, 284 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006493" } ] }, { "id": "4672", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 293, 309 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "4673", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 311, 314 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "4674", "type": "Disease", "text": [ "HIT" ], "offsets": [ [ 319, 322 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "4675", "type": "Disease", "text": [ "thrombosis" ], "offsets": [ [ 328, 338 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "4676", "type": "Disease", "text": [ "HITT" ], "offsets": [ [ 340, 344 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" }, { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "4677", "type": "Disease", "text": [ "critically ill" ], "offsets": [ [ 426, 440 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016638" } ] }, { "id": "4678", "type": "Disease", "text": [ "HITT" ], "offsets": [ [ 477, 481 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" }, { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "4679", "type": "Chemical", "text": [ "argatroban" ], "offsets": [ [ 499, 509 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C031942" } ] }, { "id": "4680", "type": "Disease", "text": [ "intraoperative and postoperative bleeding" ], "offsets": [ [ 789, 830 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016063" }, { "db_name": "MESH", "db_id": "D019106" } ] }, { "id": "4681", "type": "Disease", "text": [ "intraoperative", "bleeding" ], "offsets": [ [ 789, 803 ], [ 822, 830 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016063" } ] }, { "id": "4682", "type": "Disease", "text": [ "postoperative bleeding" ], "offsets": [ [ 808, 830 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D019106" } ] }, { "id": "4683", "type": "Chemical", "text": [ "argatroban" ], "offsets": [ [ 933, 943 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C031942" } ] }, { "id": "4684", "type": "Chemical", "text": [ "argatroban" ], "offsets": [ [ 1054, 1064 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C031942" } ] }, { "id": "4685", "type": "Chemical", "text": [ "argatroban" ], "offsets": [ [ 1144, 1154 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C031942" } ] }, { "id": "4686", "type": "Disease", "text": [ "hepatic impairment" ], "offsets": [ [ 1274, 1292 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008107" } ] }, { "id": "4687", "type": "Chemical", "text": [ "argatroban" ], "offsets": [ [ 1331, 1341 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C031942" } ] }, { "id": "4688", "type": "Chemical", "text": [ "argatroban" ], "offsets": [ [ 1468, 1478 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C031942" } ] }, { "id": "4689", "type": "Disease", "text": [ "coagulopathy" ], "offsets": [ [ 1526, 1538 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001778" } ] }, { "id": "4690", "type": "Chemical", "text": [ "argatroban" ], "offsets": [ [ 1776, 1786 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C031942" } ] }, { "id": "4691", "type": "Disease", "text": [ "coagulopathy" ], "offsets": [ [ 1836, 1848 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001778" } ] } ]

[]

[]

[ { "id": "4692", "type": "CID", "arg1_id": "4667", "arg2_id": "4680", "normalized": [] }, { "id": "4693", "type": "CID", "arg1_id": "4667", "arg2_id": "4681", "normalized": [] }, { "id": "4694", "type": "CID", "arg1_id": "4679", "arg2_id": "4680", "normalized": [] }, { "id": "4695", "type": "CID", "arg1_id": "4679", "arg2_id": "4681", "normalized": [] }, { "id": "4696", "type": "CID", "arg1_id": "4683", "arg2_id": "4680", "normalized": [] }, { "id": "4697", "type": "CID", "arg1_id": "4683", "arg2_id": "4681", "normalized": [] }, { "id": "4698", "type": "CID", "arg1_id": "4684", "arg2_id": "4680", "normalized": [] }, { "id": "4699", "type": "CID", "arg1_id": "4684", "arg2_id": "4681", "normalized": [] }, { "id": "4700", "type": "CID", "arg1_id": "4685", "arg2_id": "4680", "normalized": [] }, { "id": "4701", "type": "CID", "arg1_id": "4685", "arg2_id": "4681", "normalized": [] }, { "id": "4702", "type": "CID", "arg1_id": "4687", "arg2_id": "4680", "normalized": [] }, { "id": "4703", "type": "CID", "arg1_id": "4687", "arg2_id": "4681", "normalized": [] }, { "id": "4704", "type": "CID", "arg1_id": "4688", "arg2_id": "4680", "normalized": [] }, { "id": "4705", "type": "CID", "arg1_id": "4688", "arg2_id": "4681", "normalized": [] }, { "id": "4706", "type": "CID", "arg1_id": "4690", "arg2_id": "4680", "normalized": [] }, { "id": "4707", "type": "CID", "arg1_id": "4690", "arg2_id": "4681", "normalized": [] }, { "id": "4708", "type": "CID", "arg1_id": "4667", "arg2_id": "4680", "normalized": [] }, { "id": "4709", "type": "CID", "arg1_id": "4667", "arg2_id": "4682", "normalized": [] }, { "id": "4710", "type": "CID", "arg1_id": "4679", "arg2_id": "4680", "normalized": [] }, { "id": "4711", "type": "CID", "arg1_id": "4679", "arg2_id": "4682", "normalized": [] }, { "id": "4712", "type": "CID", "arg1_id": "4683", "arg2_id": "4680", "normalized": [] }, { "id": "4713", "type": "CID", "arg1_id": "4683", "arg2_id": "4682", "normalized": [] }, { "id": "4714", "type": "CID", "arg1_id": "4684", "arg2_id": "4680", "normalized": [] }, { "id": "4715", "type": "CID", "arg1_id": "4684", "arg2_id": "4682", "normalized": [] }, { "id": "4716", "type": "CID", "arg1_id": "4685", "arg2_id": "4680", "normalized": [] }, { "id": "4717", "type": "CID", "arg1_id": "4685", "arg2_id": "4682", "normalized": [] }, { "id": "4718", "type": "CID", "arg1_id": "4687", "arg2_id": "4680", "normalized": [] }, { "id": "4719", "type": "CID", "arg1_id": "4687", "arg2_id": "4682", "normalized": [] }, { "id": "4720", "type": "CID", "arg1_id": "4688", "arg2_id": "4680", "normalized": [] }, { "id": "4721", "type": "CID", "arg1_id": "4688", "arg2_id": "4682", "normalized": [] }, { "id": "4722", "type": "CID", "arg1_id": "4690", "arg2_id": "4680", "normalized": [] }, { "id": "4723", "type": "CID", "arg1_id": "4690", "arg2_id": "4682", "normalized": [] } ]

[ { "id": "4725", "type": "title", "text": [ "Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome." ], "offsets": [ [ 0, 111 ] ] }, { "id": "4726", "type": "abstract", "text": [ "Antituberculosis therapy (ATT)-associated acute liver failure (ATT-ALF) is the commonest drug-induced ALF in South Asia. Prospective studies on ATT-ALF are lacking. The current study prospectively evaluated the magnitude, clinical course, outcome, and prognostic factors in ATT-ALF. From January 1986 to January 2009, 1223 consecutive ALF patients were evaluated: ATT alone was the cause in 70 (5.7%) patients. Another 15 (1.2%) had ATT and simultaneous hepatitis virus infection. In 44 (62.8%) patients, ATT was prescribed empirically without definitive evidence of tuberculosis. ATT-ALF patients were younger (32.87 [+/-15.8] years), and 49 (70%) of them were women. Most had hyperacute presentation; the median icterus encephalopathy interval was 4.5 (0-30) days. The median duration of ATT before ALF was 30 (7-350) days. At presentation, advanced encephalopathy and cerebral edema were present in 51 (76%) and 29 (41.4%) patients, respectively. Gastrointestinal bleed, seizures, infection, and acute renal failure were documented in seven (10%), five (7.1%), 26 (37.1%), and seven (10%) patients, respectively. Compared with hepatitis E virus (HEV) and non-A non-E-induced ALF, ATT-ALF patients had nearly similar presentations except for older age and less elevation of liver enzymes. The mortality rate among patients with ATT-ALF was high (67.1%, n = 47), and only 23 (32.9%) patients recovered with medical treatment. In multivariate analysis, three factors independently predicted mortality: serum bilirubin (>or=10.8 mg/dL), prothrombin time (PT) prolongation (>or=26 seconds), and grade III/IV encephalopathy at presentation. CONCLUSION: ATT-ALF constituted 5.7% of ALF at our center and had a high mortality rate. Because the mortality rate is so high, determining which factors are predictors is less important. A high proportion of patients had consumed ATT empirically, which could have been prevented." ], "offsets": [ [ 112, 2030 ] ] } ]

[ { "id": "4727", "type": "Chemical", "text": [ "Antituberculosis" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000995" } ] }, { "id": "4728", "type": "Disease", "text": [ "acute liver failure" ], "offsets": [ [ 33, 52 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4729", "type": "Chemical", "text": [ "Antituberculosis" ], "offsets": [ [ 112, 128 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000995" } ] }, { "id": "4730", "type": "Disease", "text": [ "acute liver failure" ], "offsets": [ [ 154, 173 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4731", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 179, 182 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4732", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 214, 217 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4733", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 260, 263 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4734", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 390, 393 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4735", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 447, 450 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4736", "type": "Disease", "text": [ "hepatitis virus infection" ], "offsets": [ [ 566, 591 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006525" } ] }, { "id": "4737", "type": "Disease", "text": [ "tuberculosis" ], "offsets": [ [ 679, 691 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014376" } ] }, { "id": "4738", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 697, 700 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4739", "type": "Disease", "text": [ "icterus" ], "offsets": [ [ 826, 833 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007565" } ] }, { "id": "4740", "type": "Disease", "text": [ "encephalopathy" ], "offsets": [ [ 834, 848 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001927" } ] }, { "id": "4741", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 913, 916 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4742", "type": "Disease", "text": [ "encephalopathy" ], "offsets": [ [ 964, 978 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001927" } ] }, { "id": "4743", "type": "Disease", "text": [ "cerebral edema" ], "offsets": [ [ 983, 997 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001929" } ] }, { "id": "4744", "type": "Disease", "text": [ "Gastrointestinal bleed" ], "offsets": [ [ 1062, 1084 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006471" } ] }, { "id": "4745", "type": "Disease", "text": [ "seizures" ], "offsets": [ [ 1086, 1094 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D012640" } ] }, { "id": "4746", "type": "Disease", "text": [ "infection" ], "offsets": [ [ 1096, 1105 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007239" } ] }, { "id": "4747", "type": "Disease", "text": [ "acute renal failure" ], "offsets": [ [ 1111, 1130 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D058186" } ] }, { "id": "4748", "type": "Disease", "text": [ "hepatitis E" ], "offsets": [ [ 1242, 1253 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D016751" } ] }, { "id": "4749", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 1290, 1293 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4750", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 1299, 1302 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4751", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 1446, 1449 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4752", "type": "Chemical", "text": [ "bilirubin" ], "offsets": [ [ 1620, 1629 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001663" } ] }, { "id": "4753", "type": "Disease", "text": [ "encephalopathy" ], "offsets": [ [ 1718, 1732 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001927" } ] }, { "id": "4754", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 1766, 1769 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] }, { "id": "4755", "type": "Disease", "text": [ "ALF" ], "offsets": [ [ 1790, 1793 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017114" } ] } ]

[]

[]

[ { "id": "4756", "type": "CID", "arg1_id": "4727", "arg2_id": "4728", "normalized": [] }, { "id": "4757", "type": "CID", "arg1_id": "4727", "arg2_id": "4730", "normalized": [] }, { "id": "4758", "type": "CID", "arg1_id": "4727", "arg2_id": "4731", "normalized": [] }, { "id": "4759", "type": "CID", "arg1_id": "4727", "arg2_id": "4732", "normalized": [] }, { "id": "4760", "type": "CID", "arg1_id": "4727", "arg2_id": "4733", "normalized": [] }, { "id": "4761", "type": "CID", "arg1_id": "4727", "arg2_id": "4734", "normalized": [] }, { "id": "4762", "type": "CID", "arg1_id": "4727", "arg2_id": "4735", "normalized": [] }, { "id": "4763", "type": "CID", "arg1_id": "4727", "arg2_id": "4738", "normalized": [] }, { "id": "4764", "type": "CID", "arg1_id": "4727", "arg2_id": "4741", "normalized": [] }, { "id": "4765", "type": "CID", "arg1_id": "4727", "arg2_id": "4749", "normalized": [] }, { "id": "4766", "type": "CID", "arg1_id": "4727", "arg2_id": "4750", "normalized": [] }, { "id": "4767", "type": "CID", "arg1_id": "4727", "arg2_id": "4751", "normalized": [] }, { "id": "4768", "type": "CID", "arg1_id": "4727", "arg2_id": "4754", "normalized": [] }, { "id": "4769", "type": "CID", "arg1_id": "4727", "arg2_id": "4755", "normalized": [] }, { "id": "4770", "type": "CID", "arg1_id": "4729", "arg2_id": "4728", "normalized": [] }, { "id": "4771", "type": "CID", "arg1_id": "4729", "arg2_id": "4730", "normalized": [] }, { "id": "4772", "type": "CID", "arg1_id": "4729", "arg2_id": "4731", "normalized": [] }, { "id": "4773", "type": "CID", "arg1_id": "4729", "arg2_id": "4732", "normalized": [] }, { "id": "4774", "type": "CID", "arg1_id": "4729", "arg2_id": "4733", "normalized": [] }, { "id": "4775", "type": "CID", "arg1_id": "4729", "arg2_id": "4734", "normalized": [] }, { "id": "4776", "type": "CID", "arg1_id": "4729", "arg2_id": "4735", "normalized": [] }, { "id": "4777", "type": "CID", "arg1_id": "4729", "arg2_id": "4738", "normalized": [] }, { "id": "4778", "type": "CID", "arg1_id": "4729", "arg2_id": "4741", "normalized": [] }, { "id": "4779", "type": "CID", "arg1_id": "4729", "arg2_id": "4749", "normalized": [] }, { "id": "4780", "type": "CID", "arg1_id": "4729", "arg2_id": "4750", "normalized": [] }, { "id": "4781", "type": "CID", "arg1_id": "4729", "arg2_id": "4751", "normalized": [] }, { "id": "4782", "type": "CID", "arg1_id": "4729", "arg2_id": "4754", "normalized": [] }, { "id": "4783", "type": "CID", "arg1_id": "4729", "arg2_id": "4755", "normalized": [] } ]

[ { "id": "4785", "type": "title", "text": [ "Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution." ], "offsets": [ [ 0, 120 ] ] }, { "id": "4786", "type": "abstract", "text": [ "Central nervous system (CNS) complications during treatment of childhood acute lymphoblastic leukemia (ALL) remain a challenging clinical problem. Outcome improvement with more intensive chemotherapy has significantly increased the incidence and severity of adverse events. This study analyzed the incidence of neurological complications during ALL treatment in a single pediatric institution, focusing on clinical, radiological, and electrophysiological findings. Exclusion criteria included CNS leukemic infiltration at diagnosis, therapy-related peripheral neuropathy, late-onset encephalopathy, or long-term neurocognitive defects. During a 9-year period, we retrospectively collected 27 neurological events (11%) in as many patients, from 253 children enrolled in the ALL front-line protocol. CNS complications included posterior reversible leukoencephalopathy syndrome (n = 10), stroke (n = 5), temporal lobe epilepsy (n = 2), high-dose methotrexate toxicity (n = 2), syndrome of inappropriate antidiuretic hormone secretion (n = 1), and other unclassified events (n = 7). In conclusion, CNS complications are frequent events during ALL therapy, and require rapid detection and prompt treatment to limit permanent damage." ], "offsets": [ [ 121, 1348 ] ] } ]

[ { "id": "4787", "type": "Disease", "text": [ "Central nervous system complications" ], "offsets": [ [ 0, 36 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002493" } ] }, { "id": "4788", "type": "Disease", "text": [ "acute lymphoblastic leukemia" ], "offsets": [ [ 57, 85 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054198" } ] }, { "id": "4789", "type": "Disease", "text": [ "Central nervous system (CNS) complications" ], "offsets": [ [ 121, 163 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002493" } ] }, { "id": "4790", "type": "Disease", "text": [ "acute lymphoblastic leukemia" ], "offsets": [ [ 194, 222 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054198" } ] }, { "id": "4791", "type": "Disease", "text": [ "ALL" ], "offsets": [ [ 224, 227 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054198" } ] }, { "id": "4792", "type": "Disease", "text": [ "neurological complications" ], "offsets": [ [ 432, 458 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002493" } ] }, { "id": "4793", "type": "Disease", "text": [ "ALL" ], "offsets": [ [ 466, 469 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054198" } ] }, { "id": "4794", "type": "Disease", "text": [ "leukemic infiltration" ], "offsets": [ [ 618, 639 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017254" } ] }, { "id": "4795", "type": "Disease", "text": [ "peripheral neuropathy" ], "offsets": [ [ 670, 691 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010523" } ] }, { "id": "4796", "type": "Disease", "text": [ "encephalopathy" ], "offsets": [ [ 704, 718 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001927" } ] }, { "id": "4797", "type": "Disease", "text": [ "neurocognitive defects" ], "offsets": [ [ 733, 755 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002493" } ] }, { "id": "4798", "type": "Disease", "text": [ "ALL" ], "offsets": [ [ 894, 897 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054198" } ] }, { "id": "4799", "type": "Disease", "text": [ "leukoencephalopathy" ], "offsets": [ [ 967, 986 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056784" } ] }, { "id": "4800", "type": "Disease", "text": [ "stroke" ], "offsets": [ [ 1006, 1012 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "4801", "type": "Disease", "text": [ "temporal lobe epilepsy" ], "offsets": [ [ 1022, 1044 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004833" } ] }, { "id": "4802", "type": "Chemical", "text": [ "methotrexate" ], "offsets": [ [ 1064, 1076 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008727" } ] }, { "id": "4803", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 1077, 1085 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "4804", "type": "Disease", "text": [ "inappropriate antidiuretic hormone secretion" ], "offsets": [ [ 1107, 1151 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007177" } ] }, { "id": "4805", "type": "Disease", "text": [ "ALL" ], "offsets": [ [ 1260, 1263 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054198" } ] } ]

[]

[]

[ { "id": "4806", "type": "CID", "arg1_id": "4802", "arg2_id": "4787", "normalized": [] }, { "id": "4807", "type": "CID", "arg1_id": "4802", "arg2_id": "4789", "normalized": [] }, { "id": "4808", "type": "CID", "arg1_id": "4802", "arg2_id": "4792", "normalized": [] }, { "id": "4809", "type": "CID", "arg1_id": "4802", "arg2_id": "4797", "normalized": [] } ]

[ { "id": "4811", "type": "title", "text": [ "Safety of capecitabine: a review." ], "offsets": [ [ 0, 33 ] ] }, { "id": "4812", "type": "abstract", "text": [ "IMPORTANCE OF THE FIELD: Fluoropyrimidines, in particular 5-fluorouracil (5-FU), have been the mainstay of treatment for several solid tumors, including colorectal, breast and head and neck cancers, for > 40 years. AREAS COVERED IN THIS REVIEW: This article reviews the pharmacology and efficacy of capecitabine with a special emphasis on its safety. WHAT THE READER WILL GAIN: The reader will gain better insight into the safety of capecitabine in special populations such as patients with advanced age, renal and kidney disease. We also explore different dosing and schedules of capecitabine administration. TAKE HOME MESSAGE: Capecitabine is an oral prodrug of 5-FU and was developed to fulfill the need for a more convenient therapy and provide an improved safety/efficacy profile. It has shown promising results alone or in combination with other chemotherapeutic agents in colorectal, breast, pancreaticobiliary, gastric, renal cell and head and neck cancers. The most commonly reported toxic effects of capecitabine are diarrhea, nausea, vomiting, stomatitis and hand-foot syndrome. Capecitabine has a well-established safety profile and can be given safely to patients with advanced age, hepatic and renal dysfunctions." ], "offsets": [ [ 34, 1261 ] ] } ]

[ { "id": "4813", "type": "Chemical", "text": [ "capecitabine" ], "offsets": [ [ 10, 22 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C110904" } ] }, { "id": "4814", "type": "Chemical", "text": [ "Fluoropyrimidines" ], "offsets": [ [ 59, 76 ] ], "normalized": [] }, { "id": "4815", "type": "Chemical", "text": [ "5-fluorouracil" ], "offsets": [ [ 92, 106 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005472" } ] }, { "id": "4816", "type": "Chemical", "text": [ "5-FU" ], "offsets": [ [ 108, 112 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005472" } ] }, { "id": "4817", "type": "Disease", "text": [ "tumors" ], "offsets": [ [ 169, 175 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "4818", "type": "Disease", "text": [ "colorectal, breast and head and neck cancers" ], "offsets": [ [ 187, 231 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015179" }, { "db_name": "MESH", "db_id": "D001943" }, { "db_name": "MESH", "db_id": "D006258" } ] }, { "id": "4819", "type": "Disease", "text": [ "colorectal", "cancers" ], "offsets": [ [ 187, 197 ], [ 223, 230 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015179" } ] }, { "id": "4820", "type": "Disease", "text": [ "breast", "cancers" ], "offsets": [ [ 199, 205 ], [ 224, 231 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001943" } ] }, { "id": "4821", "type": "Disease", "text": [ "head and neck cancers" ], "offsets": [ [ 210, 231 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006258" } ] }, { "id": "4822", "type": "Chemical", "text": [ "capecitabine" ], "offsets": [ [ 333, 345 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C110904" } ] }, { "id": "4823", "type": "Chemical", "text": [ "capecitabine" ], "offsets": [ [ 467, 479 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C110904" } ] }, { "id": "4824", "type": "Disease", "text": [ "renal and kidney disease" ], "offsets": [ [ 539, 563 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "4825", "type": "Chemical", "text": [ "capecitabine" ], "offsets": [ [ 615, 627 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C110904" } ] }, { "id": "4826", "type": "Chemical", "text": [ "Capecitabine" ], "offsets": [ [ 663, 675 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C110904" } ] }, { "id": "4827", "type": "Chemical", "text": [ "5-FU" ], "offsets": [ [ 698, 702 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005472" } ] }, { "id": "4828", "type": "Disease", "text": [ "colorectal, breast, pancreaticobiliary, gastric, renal cell and head and neck cancers" ], "offsets": [ [ 913, 998 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015179" }, { "db_name": "MESH", "db_id": "D001943" }, { "db_name": "MESH", "db_id": "D010190" }, { "db_name": "MESH", "db_id": "D013274" }, { "db_name": "MESH", "db_id": "D002292" }, { "db_name": "MESH", "db_id": "D006258" } ] }, { "id": "4829", "type": "Disease", "text": [ "colorectal", "cancers" ], "offsets": [ [ 913, 923 ], [ 991, 998 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015179" } ] }, { "id": "4830", "type": "Disease", "text": [ "breast", "cancers" ], "offsets": [ [ 925, 931 ], [ 991, 998 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001943" } ] }, { "id": "4831", "type": "Disease", "text": [ "pancreaticobiliary", "cancers" ], "offsets": [ [ 933, 951 ], [ 991, 998 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010190" } ] }, { "id": "4832", "type": "Disease", "text": [ "gastric", "cancers" ], "offsets": [ [ 953, 960 ], [ 991, 998 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013274" } ] }, { "id": "4833", "type": "Disease", "text": [ "renal cell", "cancers" ], "offsets": [ [ 962, 972 ], [ 991, 998 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002292" } ] }, { "id": "4834", "type": "Disease", "text": [ "head and neck cancers" ], "offsets": [ [ 977, 998 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006258" } ] }, { "id": "4835", "type": "Chemical", "text": [ "capecitabine" ], "offsets": [ [ 1044, 1056 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C110904" } ] }, { "id": "4836", "type": "Disease", "text": [ "diarrhea" ], "offsets": [ [ 1061, 1069 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003967" } ] }, { "id": "4837", "type": "Disease", "text": [ "nausea" ], "offsets": [ [ 1071, 1077 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009325" } ] }, { "id": "4838", "type": "Disease", "text": [ "vomiting" ], "offsets": [ [ 1079, 1087 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014839" } ] }, { "id": "4839", "type": "Disease", "text": [ "stomatitis" ], "offsets": [ [ 1089, 1099 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013280" } ] }, { "id": "4840", "type": "Disease", "text": [ "hand-foot syndrome" ], "offsets": [ [ 1104, 1122 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D060831" } ] }, { "id": "4841", "type": "Chemical", "text": [ "Capecitabine" ], "offsets": [ [ 1124, 1136 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C110904" } ] }, { "id": "4842", "type": "Disease", "text": [ "hepatic and renal dysfunctions" ], "offsets": [ [ 1230, 1260 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008107" }, { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "4843", "type": "Disease", "text": [ "hepatic", "dysfunctions" ], "offsets": [ [ 1230, 1237 ], [ 1248, 1260 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008107" } ] }, { "id": "4844", "type": "Disease", "text": [ "renal dysfunctions" ], "offsets": [ [ 1242, 1260 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] } ]

[]

[]

[ { "id": "4845", "type": "CID", "arg1_id": "4813", "arg2_id": "4840", "normalized": [] }, { "id": "4846", "type": "CID", "arg1_id": "4822", "arg2_id": "4840", "normalized": [] }, { "id": "4847", "type": "CID", "arg1_id": "4823", "arg2_id": "4840", "normalized": [] }, { "id": "4848", "type": "CID", "arg1_id": "4825", "arg2_id": "4840", "normalized": [] }, { "id": "4849", "type": "CID", "arg1_id": "4826", "arg2_id": "4840", "normalized": [] }, { "id": "4850", "type": "CID", "arg1_id": "4835", "arg2_id": "4840", "normalized": [] }, { "id": "4851", "type": "CID", "arg1_id": "4841", "arg2_id": "4840", "normalized": [] }, { "id": "4852", "type": "CID", "arg1_id": "4813", "arg2_id": "4839", "normalized": [] }, { "id": "4853", "type": "CID", "arg1_id": "4822", "arg2_id": "4839", "normalized": [] }, { "id": "4854", "type": "CID", "arg1_id": "4823", "arg2_id": "4839", "normalized": [] }, { "id": "4855", "type": "CID", "arg1_id": "4825", "arg2_id": "4839", "normalized": [] }, { "id": "4856", "type": "CID", "arg1_id": "4826", "arg2_id": "4839", "normalized": [] }, { "id": "4857", "type": "CID", "arg1_id": "4835", "arg2_id": "4839", "normalized": [] }, { "id": "4858", "type": "CID", "arg1_id": "4841", "arg2_id": "4839", "normalized": [] }, { "id": "4859", "type": "CID", "arg1_id": "4813", "arg2_id": "4838", "normalized": [] }, { "id": "4860", "type": "CID", "arg1_id": "4822", "arg2_id": "4838", "normalized": [] }, { "id": "4861", "type": "CID", "arg1_id": "4823", "arg2_id": "4838", "normalized": [] }, { "id": "4862", "type": "CID", "arg1_id": "4825", "arg2_id": "4838", "normalized": [] }, { "id": "4863", "type": "CID", "arg1_id": "4826", "arg2_id": "4838", "normalized": [] }, { "id": "4864", "type": "CID", "arg1_id": "4835", "arg2_id": "4838", "normalized": [] }, { "id": "4865", "type": "CID", "arg1_id": "4841", "arg2_id": "4838", "normalized": [] }, { "id": "4866", "type": "CID", "arg1_id": "4813", "arg2_id": "4836", "normalized": [] }, { "id": "4867", "type": "CID", "arg1_id": "4822", "arg2_id": "4836", "normalized": [] }, { "id": "4868", "type": "CID", "arg1_id": "4823", "arg2_id": "4836", "normalized": [] }, { "id": "4869", "type": "CID", "arg1_id": "4825", "arg2_id": "4836", "normalized": [] }, { "id": "4870", "type": "CID", "arg1_id": "4826", "arg2_id": "4836", "normalized": [] }, { "id": "4871", "type": "CID", "arg1_id": "4835", "arg2_id": "4836", "normalized": [] }, { "id": "4872", "type": "CID", "arg1_id": "4841", "arg2_id": "4836", "normalized": [] }, { "id": "4873", "type": "CID", "arg1_id": "4813", "arg2_id": "4837", "normalized": [] }, { "id": "4874", "type": "CID", "arg1_id": "4822", "arg2_id": "4837", "normalized": [] }, { "id": "4875", "type": "CID", "arg1_id": "4823", "arg2_id": "4837", "normalized": [] }, { "id": "4876", "type": "CID", "arg1_id": "4825", "arg2_id": "4837", "normalized": [] }, { "id": "4877", "type": "CID", "arg1_id": "4826", "arg2_id": "4837", "normalized": [] }, { "id": "4878", "type": "CID", "arg1_id": "4835", "arg2_id": "4837", "normalized": [] }, { "id": "4879", "type": "CID", "arg1_id": "4841", "arg2_id": "4837", "normalized": [] } ]

[ { "id": "4881", "type": "title", "text": [ "Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and electrophysiological studies." ], "offsets": [ [ 0, 123 ] ] }, { "id": "4882", "type": "abstract", "text": [ "OBJECTIVE: The globus pallidus plays a critical role in movement regulation. Previous studies have indicated that the globus pallidus receives neurotensinergic innervation from the striatum, and systemic administration of a neurotensin analog could produce antiparkinsonian effects. The present study aimed to investigate the effects of pallidal neurotensin on haloperidol-induced parkinsonian symptoms. METHODS: Behavioral experiments and electrophysiological recordings were performed in the present study. RESULTS: Bilateral infusions of neurotensin into the globus pallidus reversed haloperidol-induced parkinsonian catalepsy in rats. Electrophysiological recordings showed that microinjection of neurotensin induced excitation of pallidal neurons in the presence of systemic haloperidol administration. The neurotensin type-1 receptor antagonist SR48692 blocked both the behavioral and the electrophysiological effects induced by neurotensin. CONCLUSION: Activation of pallidal neurotensin receptors may be involved in neurotensin-induced antiparkinsonian effects." ], "offsets": [ [ 124, 1193 ] ] } ]

[ { "id": "4883", "type": "Chemical", "text": [ "neurotensin" ], "offsets": [ [ 20, 31 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009496" } ] }, { "id": "4884", "type": "Chemical", "text": [ "haloperidol" ], "offsets": [ [ 35, 46 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006220" } ] }, { "id": "4885", "type": "Disease", "text": [ "parkinsonian catalepsy" ], "offsets": [ [ 55, 77 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002375" } ] }, { "id": "4886", "type": "Chemical", "text": [ "neurotensin" ], "offsets": [ [ 348, 359 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009496" } ] }, { "id": "4887", "type": "Chemical", "text": [ "neurotensin" ], "offsets": [ [ 470, 481 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009496" } ] }, { "id": "4888", "type": "Chemical", "text": [ "haloperidol" ], "offsets": [ [ 485, 496 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006220" } ] }, { "id": "4889", "type": "Disease", "text": [ "parkinsonian symptoms" ], "offsets": [ [ 505, 526 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010302" } ] }, { "id": "4890", "type": "Chemical", "text": [ "neurotensin" ], "offsets": [ [ 665, 676 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009496" } ] }, { "id": "4891", "type": "Chemical", "text": [ "haloperidol" ], "offsets": [ [ 711, 722 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006220" } ] }, { "id": "4892", "type": "Disease", "text": [ "parkinsonian catalepsy" ], "offsets": [ [ 731, 753 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002375" } ] }, { "id": "4893", "type": "Chemical", "text": [ "neurotensin" ], "offsets": [ [ 825, 836 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009496" } ] }, { "id": "4894", "type": "Chemical", "text": [ "haloperidol" ], "offsets": [ [ 904, 915 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006220" } ] }, { "id": "4895", "type": "Chemical", "text": [ "neurotensin type-1 receptor antagonist" ], "offsets": [ [ 936, 974 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C079087" } ] }, { "id": "4896", "type": "Chemical", "text": [ "SR48692" ], "offsets": [ [ 975, 982 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C079087" } ] }, { "id": "4897", "type": "Chemical", "text": [ "neurotensin" ], "offsets": [ [ 1059, 1070 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009496" } ] }, { "id": "4898", "type": "Chemical", "text": [ "neurotensin" ], "offsets": [ [ 1107, 1118 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009496" } ] }, { "id": "4899", "type": "Chemical", "text": [ "neurotensin" ], "offsets": [ [ 1148, 1159 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009496" } ] } ]

[]

[]

[ { "id": "4900", "type": "CID", "arg1_id": "4884", "arg2_id": "4885", "normalized": [] }, { "id": "4901", "type": "CID", "arg1_id": "4884", "arg2_id": "4892", "normalized": [] }, { "id": "4902", "type": "CID", "arg1_id": "4888", "arg2_id": "4885", "normalized": [] }, { "id": "4903", "type": "CID", "arg1_id": "4888", "arg2_id": "4892", "normalized": [] }, { "id": "4904", "type": "CID", "arg1_id": "4891", "arg2_id": "4885", "normalized": [] }, { "id": "4905", "type": "CID", "arg1_id": "4891", "arg2_id": "4892", "normalized": [] }, { "id": "4906", "type": "CID", "arg1_id": "4894", "arg2_id": "4885", "normalized": [] }, { "id": "4907", "type": "CID", "arg1_id": "4894", "arg2_id": "4892", "normalized": [] } ]

[ { "id": "4909", "type": "title", "text": [ "Antihypertensive drugs and depression: a reappraisal." ], "offsets": [ [ 0, 53 ] ] }, { "id": "4910", "type": "abstract", "text": [ "Eighty-nine new referral hypertensive out-patients and 46 new referral non-hypertensive chronically physically ill out-patients completed a mood rating scale at regular intervals for one year. The results showed a high prevalence of depression in both groups of patients, with no preponderance in the hypertensive group. Hypertensive patients with psychiatric histories had a higher prevalence of depression than the comparison patients. This was accounted for by a significant number of depressions occurring in methyl dopa treated patients with psychiatric histories." ], "offsets": [ [ 54, 623 ] ] } ]

[ { "id": "4911", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 27, 37 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "4912", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 79, 91 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "4913", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 129, 141 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "4914", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 287, 297 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "4915", "type": "Disease", "text": [ "hypertensive" ], "offsets": [ [ 355, 367 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "4916", "type": "Disease", "text": [ "Hypertensive" ], "offsets": [ [ 375, 387 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006973" } ] }, { "id": "4917", "type": "Disease", "text": [ "psychiatric" ], "offsets": [ [ 402, 413 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001523" } ] }, { "id": "4918", "type": "Disease", "text": [ "depression" ], "offsets": [ [ 451, 461 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "4919", "type": "Disease", "text": [ "depressions" ], "offsets": [ [ 542, 553 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003866" } ] }, { "id": "4920", "type": "Chemical", "text": [ "methyl dopa" ], "offsets": [ [ 567, 578 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008750" } ] }, { "id": "4921", "type": "Disease", "text": [ "psychiatric" ], "offsets": [ [ 601, 612 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001523" } ] } ]

[]

[]

[ { "id": "4922", "type": "CID", "arg1_id": "4920", "arg2_id": "4911", "normalized": [] }, { "id": "4923", "type": "CID", "arg1_id": "4920", "arg2_id": "4914", "normalized": [] }, { "id": "4924", "type": "CID", "arg1_id": "4920", "arg2_id": "4918", "normalized": [] }, { "id": "4925", "type": "CID", "arg1_id": "4920", "arg2_id": "4919", "normalized": [] } ]

[ { "id": "4927", "type": "title", "text": [ "Pulmonary shunt and cardiovascular responses to CPAP during nitroprusside-induced hypotension." ], "offsets": [ [ 0, 94 ] ] }, { "id": "4928", "type": "abstract", "text": [ "The effects of continuous positive airway pressure (CPAP) on cardiovascular dynamics and pulmonary shunt (QS/QT) were investigated in 12 dogs before and during sodium nitroprusside infusion that decreased mean arterial blood pressure 40-50 per cent. Before nitroprusside infusion, 5 cm H2O CPAP significantly, P less than .05, decreased arterial blood pressure, but did not significantly alter heart rate, cardiac output, systemic vascular resistance, or QS/QT. Ten cm H2O CPAP before nitroprusside infusion produced a further decrease in arterial blood pressure and significantly increased heart rate and decreased cardiac output and QS/QT. Nitroprusside caused significant decreases in arterial blood pressure and systemic vascular resistance and increases in heart rate, but did not change cardiac output or QS/QT. Five cm H2O CPAP during nitroprusside did not further alter any of the above-mentioned variables. However, 10 cm H2O CPAP decreased arterial blood pressure, cardiac output, and QS/QT. These data indicate that nitroprusside infusion rates that decrease mean arterial blood pressure by 40-50 per cent do not change cardiac output or QS/QT. During nitroprusside infusion low levels of CPAP do not markedly alter cardiovascular dynamics, but high levels of CPAP (10 cm H2O), while decreasing QS/QT, produce marked decreases in arterial blood pressure and cardiac output." ], "offsets": [ [ 95, 1479 ] ] } ]

[ { "id": "4929", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 60, 73 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "4930", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 82, 93 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "4931", "type": "Chemical", "text": [ "sodium nitroprusside" ], "offsets": [ [ 255, 275 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "4932", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 352, 365 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "4933", "type": "Chemical", "text": [ "H2O" ], "offsets": [ [ 381, 384 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014867" } ] }, { "id": "4934", "type": "Chemical", "text": [ "H2O" ], "offsets": [ [ 564, 567 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014867" } ] }, { "id": "4935", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 580, 593 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "4936", "type": "Disease", "text": [ "decrease in arterial blood pressure" ], "offsets": [ [ 622, 657 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "4937", "type": "Disease", "text": [ "decreased cardiac output" ], "offsets": [ [ 701, 725 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002303" } ] }, { "id": "4938", "type": "Chemical", "text": [ "Nitroprusside" ], "offsets": [ [ 737, 750 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "4939", "type": "Disease", "text": [ "decreases in arterial blood pressure" ], "offsets": [ [ 770, 806 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "4940", "type": "Chemical", "text": [ "H2O" ], "offsets": [ [ 921, 924 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014867" } ] }, { "id": "4941", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 937, 950 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "4942", "type": "Chemical", "text": [ "H2O" ], "offsets": [ [ 1026, 1029 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014867" } ] }, { "id": "4943", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 1122, 1135 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "4944", "type": "Chemical", "text": [ "nitroprusside" ], "offsets": [ [ 1258, 1271 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009599" } ] }, { "id": "4945", "type": "Chemical", "text": [ "H2O" ], "offsets": [ [ 1378, 1381 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014867" } ] }, { "id": "4946", "type": "Disease", "text": [ "decreases in arterial blood pressure and cardiac output" ], "offsets": [ [ 1423, 1478 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" }, { "db_name": "MESH", "db_id": "D002303" } ] }, { "id": "4947", "type": "Disease", "text": [ "decreases in arterial blood pressure" ], "offsets": [ [ 1423, 1459 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "4948", "type": "Disease", "text": [ "decreases in", "cardiac output" ], "offsets": [ [ 1423, 1435 ], [ 1464, 1478 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002303" } ] } ]

[]

[]

[ { "id": "4949", "type": "CID", "arg1_id": "4929", "arg2_id": "4930", "normalized": [] }, { "id": "4950", "type": "CID", "arg1_id": "4929", "arg2_id": "4936", "normalized": [] }, { "id": "4951", "type": "CID", "arg1_id": "4929", "arg2_id": "4939", "normalized": [] }, { "id": "4952", "type": "CID", "arg1_id": "4929", "arg2_id": "4946", "normalized": [] }, { "id": "4953", "type": "CID", "arg1_id": "4929", "arg2_id": "4947", "normalized": [] }, { "id": "4954", "type": "CID", "arg1_id": "4931", "arg2_id": "4930", "normalized": [] }, { "id": "4955", "type": "CID", "arg1_id": "4931", "arg2_id": "4936", "normalized": [] }, { "id": "4956", "type": "CID", "arg1_id": "4931", "arg2_id": "4939", "normalized": [] }, { "id": "4957", "type": "CID", "arg1_id": "4931", "arg2_id": "4946", "normalized": [] }, { "id": "4958", "type": "CID", "arg1_id": "4931", "arg2_id": "4947", "normalized": [] }, { "id": "4959", "type": "CID", "arg1_id": "4932", "arg2_id": "4930", "normalized": [] }, { "id": "4960", "type": "CID", "arg1_id": "4932", "arg2_id": "4936", "normalized": [] }, { "id": "4961", "type": "CID", "arg1_id": "4932", "arg2_id": "4939", "normalized": [] }, { "id": "4962", "type": "CID", "arg1_id": "4932", "arg2_id": "4946", "normalized": [] }, { "id": "4963", "type": "CID", "arg1_id": "4932", "arg2_id": "4947", "normalized": [] }, { "id": "4964", "type": "CID", "arg1_id": "4935", "arg2_id": "4930", "normalized": [] }, { "id": "4965", "type": "CID", "arg1_id": "4935", "arg2_id": "4936", "normalized": [] }, { "id": "4966", "type": "CID", "arg1_id": "4935", "arg2_id": "4939", "normalized": [] }, { "id": "4967", "type": "CID", "arg1_id": "4935", "arg2_id": "4946", "normalized": [] }, { "id": "4968", "type": "CID", "arg1_id": "4935", "arg2_id": "4947", "normalized": [] }, { "id": "4969", "type": "CID", "arg1_id": "4938", "arg2_id": "4930", "normalized": [] }, { "id": "4970", "type": "CID", "arg1_id": "4938", "arg2_id": "4936", "normalized": [] }, { "id": "4971", "type": "CID", "arg1_id": "4938", "arg2_id": "4939", "normalized": [] }, { "id": "4972", "type": "CID", "arg1_id": "4938", "arg2_id": "4946", "normalized": [] }, { "id": "4973", "type": "CID", "arg1_id": "4938", "arg2_id": "4947", "normalized": [] }, { "id": "4974", "type": "CID", "arg1_id": "4941", "arg2_id": "4930", "normalized": [] }, { "id": "4975", "type": "CID", "arg1_id": "4941", "arg2_id": "4936", "normalized": [] }, { "id": "4976", "type": "CID", "arg1_id": "4941", "arg2_id": "4939", "normalized": [] }, { "id": "4977", "type": "CID", "arg1_id": "4941", "arg2_id": "4946", "normalized": [] }, { "id": "4978", "type": "CID", "arg1_id": "4941", "arg2_id": "4947", "normalized": [] }, { "id": "4979", "type": "CID", "arg1_id": "4943", "arg2_id": "4930", "normalized": [] }, { "id": "4980", "type": "CID", "arg1_id": "4943", "arg2_id": "4936", "normalized": [] }, { "id": "4981", "type": "CID", "arg1_id": "4943", "arg2_id": "4939", "normalized": [] }, { "id": "4982", "type": "CID", "arg1_id": "4943", "arg2_id": "4946", "normalized": [] }, { "id": "4983", "type": "CID", "arg1_id": "4943", "arg2_id": "4947", "normalized": [] }, { "id": "4984", "type": "CID", "arg1_id": "4944", "arg2_id": "4930", "normalized": [] }, { "id": "4985", "type": "CID", "arg1_id": "4944", "arg2_id": "4936", "normalized": [] }, { "id": "4986", "type": "CID", "arg1_id": "4944", "arg2_id": "4939", "normalized": [] }, { "id": "4987", "type": "CID", "arg1_id": "4944", "arg2_id": "4946", "normalized": [] }, { "id": "4988", "type": "CID", "arg1_id": "4944", "arg2_id": "4947", "normalized": [] } ]

[ { "id": "4990", "type": "title", "text": [ "Mediation of enhanced reflex vagal bradycardia by L-dopa via central dopamine formation in dogs." ], "offsets": [ [ 0, 96 ] ] }, { "id": "4991", "type": "abstract", "text": [ "L-Dopa (5 mg/kg i.v.) decreased blood pressure and heart rate after extracerebral decarboxylase inhibition with MK-486 (25 mg/kg i.v.) in anesthetize MAO-inhibited dogs. In addition, reflex bradycardia caused by injected norepinephrine was significantly enhanced by L-dopa, DL-Threo-dihydroxyphenylserine had no effect on blood pressure, heart rate or reflex responses to norepinephrine. FLA-63, a dopamine-beta-oxidase inhibitor, did not have any effect on the hypotension, bradycardia or reflex-enhancing effect of L-dopa. Pimozide did not affect the actions of L-dopa on blood pressure and heart rate but completely blocked the enhancement of reflexes. Removal of the carotid sinuses caused an elevation blood pressure and heart rate and abolished the negative chronotropic effect of norepinephrine. However, L-dopa restored the bradycardia caused by norepinephrine in addition to decreasing blood pressure and heart rate. 5-HTP (5 mg/kg i.v.) decreased blood pressure and heart rate and decreased the reflex bradycardia to norepinephrine. It is concluded that L-dopa enhances reflex bradycardia through central alpha-receptor stimulation. Furthermore, the effects are mediated through dopamine rather than norepinephrine and do not require the carotid sinus baroreceptors." ], "offsets": [ [ 97, 1373 ] ] } ]

[ { "id": "4992", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 35, 46 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "4993", "type": "Chemical", "text": [ "L-dopa" ], "offsets": [ [ 50, 56 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007980" } ] }, { "id": "4994", "type": "Chemical", "text": [ "dopamine" ], "offsets": [ [ 69, 77 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004298" } ] }, { "id": "4995", "type": "Chemical", "text": [ "L-Dopa" ], "offsets": [ [ 97, 103 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007980" } ] }, { "id": "4996", "type": "Chemical", "text": [ "MK-486" ], "offsets": [ [ 209, 215 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002230" } ] }, { "id": "4997", "type": "Chemical", "text": [ "MAO" ], "offsets": [ [ 247, 250 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008995" } ] }, { "id": "4998", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 287, 298 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "4999", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 318, 332 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009638" } ] }, { "id": "5000", "type": "Chemical", "text": [ "L-dopa" ], "offsets": [ [ 363, 369 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007980" } ] }, { "id": "5001", "type": "Chemical", "text": [ "DL-Threo-dihydroxyphenylserine" ], "offsets": [ [ 371, 401 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D015103" } ] }, { "id": "5002", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 469, 483 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009638" } ] }, { "id": "5003", "type": "Chemical", "text": [ "FLA-63" ], "offsets": [ [ 485, 491 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005406" } ] }, { "id": "5004", "type": "Chemical", "text": [ "dopamine" ], "offsets": [ [ 495, 503 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004298" } ] }, { "id": "5005", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 559, 570 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "5006", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 572, 583 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "5007", "type": "Chemical", "text": [ "L-dopa" ], "offsets": [ [ 614, 620 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007980" } ] }, { "id": "5008", "type": "Chemical", "text": [ "Pimozide" ], "offsets": [ [ 622, 630 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010868" } ] }, { "id": "5009", "type": "Chemical", "text": [ "L-dopa" ], "offsets": [ [ 661, 667 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007980" } ] }, { "id": "5010", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 884, 898 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009638" } ] }, { "id": "5011", "type": "Chemical", "text": [ "L-dopa" ], "offsets": [ [ 909, 915 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007980" } ] }, { "id": "5012", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 929, 940 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "5013", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 951, 965 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009638" } ] }, { "id": "5014", "type": "Chemical", "text": [ "5-HTP" ], "offsets": [ [ 1023, 1028 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006916" } ] }, { "id": "5015", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 1109, 1120 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "5016", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 1124, 1138 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009638" } ] }, { "id": "5017", "type": "Chemical", "text": [ "L-dopa" ], "offsets": [ [ 1161, 1167 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007980" } ] }, { "id": "5018", "type": "Disease", "text": [ "bradycardia" ], "offsets": [ [ 1184, 1195 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001919" } ] }, { "id": "5019", "type": "Chemical", "text": [ "dopamine" ], "offsets": [ [ 1286, 1294 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004298" } ] }, { "id": "5020", "type": "Chemical", "text": [ "norepinephrine" ], "offsets": [ [ 1307, 1321 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009638" } ] } ]

[]

[]

[ { "id": "5021", "type": "CID", "arg1_id": "4999", "arg2_id": "4992", "normalized": [] }, { "id": "5022", "type": "CID", "arg1_id": "4999", "arg2_id": "4998", "normalized": [] }, { "id": "5023", "type": "CID", "arg1_id": "4999", "arg2_id": "5006", "normalized": [] }, { "id": "5024", "type": "CID", "arg1_id": "4999", "arg2_id": "5012", "normalized": [] }, { "id": "5025", "type": "CID", "arg1_id": "4999", "arg2_id": "5015", "normalized": [] }, { "id": "5026", "type": "CID", "arg1_id": "4999", "arg2_id": "5018", "normalized": [] }, { "id": "5027", "type": "CID", "arg1_id": "5002", "arg2_id": "4992", "normalized": [] }, { "id": "5028", "type": "CID", "arg1_id": "5002", "arg2_id": "4998", "normalized": [] }, { "id": "5029", "type": "CID", "arg1_id": "5002", "arg2_id": "5006", "normalized": [] }, { "id": "5030", "type": "CID", "arg1_id": "5002", "arg2_id": "5012", "normalized": [] }, { "id": "5031", "type": "CID", "arg1_id": "5002", "arg2_id": "5015", "normalized": [] }, { "id": "5032", "type": "CID", "arg1_id": "5002", "arg2_id": "5018", "normalized": [] }, { "id": "5033", "type": "CID", "arg1_id": "5010", "arg2_id": "4992", "normalized": [] }, { "id": "5034", "type": "CID", "arg1_id": "5010", "arg2_id": "4998", "normalized": [] }, { "id": "5035", "type": "CID", "arg1_id": "5010", "arg2_id": "5006", "normalized": [] }, { "id": "5036", "type": "CID", "arg1_id": "5010", "arg2_id": "5012", "normalized": [] }, { "id": "5037", "type": "CID", "arg1_id": "5010", "arg2_id": "5015", "normalized": [] }, { "id": "5038", "type": "CID", "arg1_id": "5010", "arg2_id": "5018", "normalized": [] }, { "id": "5039", "type": "CID", "arg1_id": "5013", "arg2_id": "4992", "normalized": [] }, { "id": "5040", "type": "CID", "arg1_id": "5013", "arg2_id": "4998", "normalized": [] }, { "id": "5041", "type": "CID", "arg1_id": "5013", "arg2_id": "5006", "normalized": [] }, { "id": "5042", "type": "CID", "arg1_id": "5013", "arg2_id": "5012", "normalized": [] }, { "id": "5043", "type": "CID", "arg1_id": "5013", "arg2_id": "5015", "normalized": [] }, { "id": "5044", "type": "CID", "arg1_id": "5013", "arg2_id": "5018", "normalized": [] }, { "id": "5045", "type": "CID", "arg1_id": "5016", "arg2_id": "4992", "normalized": [] }, { "id": "5046", "type": "CID", "arg1_id": "5016", "arg2_id": "4998", "normalized": [] }, { "id": "5047", "type": "CID", "arg1_id": "5016", "arg2_id": "5006", "normalized": [] }, { "id": "5048", "type": "CID", "arg1_id": "5016", "arg2_id": "5012", "normalized": [] }, { "id": "5049", "type": "CID", "arg1_id": "5016", "arg2_id": "5015", "normalized": [] }, { "id": "5050", "type": "CID", "arg1_id": "5016", "arg2_id": "5018", "normalized": [] }, { "id": "5051", "type": "CID", "arg1_id": "5020", "arg2_id": "4992", "normalized": [] }, { "id": "5052", "type": "CID", "arg1_id": "5020", "arg2_id": "4998", "normalized": [] }, { "id": "5053", "type": "CID", "arg1_id": "5020", "arg2_id": "5006", "normalized": [] }, { "id": "5054", "type": "CID", "arg1_id": "5020", "arg2_id": "5012", "normalized": [] }, { "id": "5055", "type": "CID", "arg1_id": "5020", "arg2_id": "5015", "normalized": [] }, { "id": "5056", "type": "CID", "arg1_id": "5020", "arg2_id": "5018", "normalized": [] } ]

[ { "id": "5058", "type": "title", "text": [ "Cocaine-induced myocardial infarction: clinical observations and pathogenetic considerations." ], "offsets": [ [ 0, 93 ] ] }, { "id": "5059", "type": "abstract", "text": [ "Clinical and experimental data published to date suggest several possible mechanisms by which cocaine may result in acute myocardial infarction. In individuals with preexisting, high-grade coronary arterial narrowing, acute myocardial infarction may result from an increase in myocardial oxygen demand associated with cocaine-induced increase in rate-pressure product. In other individuals with no underlying atherosclerotic obstruction, coronary occlusion may be due to spasm, thrombus, or both. With regard to spasm, the clinical findings are largely circumstantial, and the locus of cocaine-induced vasoconstriction remains speculative. Although certain clinical and experimental findings support the hypothesis that spasm involves the epicardial, medium-size vessels, other data suggest intramural vasoconstriction. Diffuse intramural vasoconstriction is not consistent with reports of segmental, discrete infarction. Whereas certain in vivo data suggest that these effects are alpha-mediated, other in vitro data suggest the opposite. The finding of cocaine-induced vasoconstriction in segments of (noninnervated) human umbilical artery suggests that the presence or absence of intact innervation is not sufficient to explain the discrepant data involving the possibility of alpha-mediated effects. Finally, the contribution of a primary, thrombotic effect of cocaine has not been excluded." ], "offsets": [ [ 94, 1489 ] ] } ]

[ { "id": "5060", "type": "Chemical", "text": [ "Cocaine" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5061", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 16, 37 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "5062", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 188, 195 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5063", "type": "Disease", "text": [ "acute myocardial infarction" ], "offsets": [ [ 210, 237 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "5064", "type": "Disease", "text": [ "acute myocardial infarction" ], "offsets": [ [ 312, 339 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "5065", "type": "Chemical", "text": [ "oxygen" ], "offsets": [ [ 382, 388 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D010100" } ] }, { "id": "5066", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 412, 419 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5067", "type": "Disease", "text": [ "atherosclerotic obstruction" ], "offsets": [ [ 503, 530 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D050197" } ] }, { "id": "5068", "type": "Disease", "text": [ "coronary occlusion" ], "offsets": [ [ 532, 550 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054059" } ] }, { "id": "5069", "type": "Disease", "text": [ "spasm" ], "offsets": [ [ 565, 570 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013035" } ] }, { "id": "5070", "type": "Disease", "text": [ "thrombus" ], "offsets": [ [ 572, 580 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "5071", "type": "Disease", "text": [ "spasm" ], "offsets": [ [ 606, 611 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013035" } ] }, { "id": "5072", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 680, 687 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5073", "type": "Disease", "text": [ "spasm" ], "offsets": [ [ 814, 819 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013035" } ] }, { "id": "5074", "type": "Disease", "text": [ "infarction" ], "offsets": [ [ 1004, 1014 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007238" } ] }, { "id": "5075", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 1149, 1156 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5076", "type": "Disease", "text": [ "thrombotic" ], "offsets": [ [ 1438, 1448 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013927" } ] }, { "id": "5077", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 1459, 1466 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] } ]

[]

[]

[ { "id": "5078", "type": "CID", "arg1_id": "5060", "arg2_id": "5061", "normalized": [] }, { "id": "5079", "type": "CID", "arg1_id": "5060", "arg2_id": "5063", "normalized": [] }, { "id": "5080", "type": "CID", "arg1_id": "5060", "arg2_id": "5064", "normalized": [] }, { "id": "5081", "type": "CID", "arg1_id": "5062", "arg2_id": "5061", "normalized": [] }, { "id": "5082", "type": "CID", "arg1_id": "5062", "arg2_id": "5063", "normalized": [] }, { "id": "5083", "type": "CID", "arg1_id": "5062", "arg2_id": "5064", "normalized": [] }, { "id": "5084", "type": "CID", "arg1_id": "5066", "arg2_id": "5061", "normalized": [] }, { "id": "5085", "type": "CID", "arg1_id": "5066", "arg2_id": "5063", "normalized": [] }, { "id": "5086", "type": "CID", "arg1_id": "5066", "arg2_id": "5064", "normalized": [] }, { "id": "5087", "type": "CID", "arg1_id": "5072", "arg2_id": "5061", "normalized": [] }, { "id": "5088", "type": "CID", "arg1_id": "5072", "arg2_id": "5063", "normalized": [] }, { "id": "5089", "type": "CID", "arg1_id": "5072", "arg2_id": "5064", "normalized": [] }, { "id": "5090", "type": "CID", "arg1_id": "5075", "arg2_id": "5061", "normalized": [] }, { "id": "5091", "type": "CID", "arg1_id": "5075", "arg2_id": "5063", "normalized": [] }, { "id": "5092", "type": "CID", "arg1_id": "5075", "arg2_id": "5064", "normalized": [] }, { "id": "5093", "type": "CID", "arg1_id": "5077", "arg2_id": "5061", "normalized": [] }, { "id": "5094", "type": "CID", "arg1_id": "5077", "arg2_id": "5063", "normalized": [] }, { "id": "5095", "type": "CID", "arg1_id": "5077", "arg2_id": "5064", "normalized": [] } ]

[ { "id": "5097", "type": "title", "text": [ "Rabbit syndrome, antidepressant use, and cerebral perfusion SPECT scan findings." ], "offsets": [ [ 0, 80 ] ] }, { "id": "5098", "type": "abstract", "text": [ "The rabbit syndrome is an extrapyramidal side effect associated with chronic neuroleptic therapy. Its occurrence in a patient being treated with imipramine is described, representing the first reported case of this syndrome in conjunction with antidepressants. Repeated cerebral perfusion SPECT scans revealed decreased basal ganglia perfusion while the movement disorder was present, and a return to normal perfusion when the rabbit syndrome resolved." ], "offsets": [ [ 81, 533 ] ] } ]

[ { "id": "5099", "type": "Disease", "text": [ "Rabbit syndrome" ], "offsets": [ [ 0, 15 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "5100", "type": "Chemical", "text": [ "antidepressant" ], "offsets": [ [ 17, 31 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "5101", "type": "Disease", "text": [ "rabbit syndrome" ], "offsets": [ [ 85, 100 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "5102", "type": "Chemical", "text": [ "imipramine" ], "offsets": [ [ 226, 236 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007099" } ] }, { "id": "5103", "type": "Chemical", "text": [ "antidepressants" ], "offsets": [ [ 325, 340 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] }, { "id": "5104", "type": "Disease", "text": [ "decreased basal ganglia perfusion" ], "offsets": [ [ 391, 424 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] }, { "id": "5105", "type": "Disease", "text": [ "movement disorder" ], "offsets": [ [ 435, 452 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009069" } ] }, { "id": "5106", "type": "Disease", "text": [ "rabbit syndrome" ], "offsets": [ [ 508, 523 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001480" } ] } ]

[]

[]

[ { "id": "5107", "type": "CID", "arg1_id": "5102", "arg2_id": "5099", "normalized": [] }, { "id": "5108", "type": "CID", "arg1_id": "5102", "arg2_id": "5101", "normalized": [] }, { "id": "5109", "type": "CID", "arg1_id": "5102", "arg2_id": "5104", "normalized": [] }, { "id": "5110", "type": "CID", "arg1_id": "5102", "arg2_id": "5106", "normalized": [] } ]

[ { "id": "5112", "type": "title", "text": [ "Acute bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease." ], "offsets": [ [ 0, 111 ] ] }, { "id": "5113", "type": "abstract", "text": [ "The bronchodilator effects of a single dose of ipratropium bromide aerosol (36 micrograms) and short-acting theophylline tablets (dose titrated to produce serum levels of 10-20 micrograms/mL) were compared in a double-blind, placebo-controlled crossover study in 21 patients with stable, chronic obstructive pulmonary disease. Mean peak forced expiratory volume in 1 second (FEV1) increases over baseline and the proportion of patients attaining at least a 15% increase in the FEV1 (responders) were 31% and 90%, respectively, for ipratropium and 17% and 50%, respectively, for theophylline. The average FEV1 increases during the 6-hour observation period were 18% for ipratropium and 8% for theophylline. The mean duration of action was 3.8 hours with ipratropium and 2.4 hours with theophylline. While side effects were rare, those experienced after theophylline use did involve the cardiovascular and gastrointestinal systems. These results show that ipratropium is a more potent bronchodilator than oral theophylline in patients with chronic airflow obstruction." ], "offsets": [ [ 112, 1178 ] ] } ]

[ { "id": "5114", "type": "Chemical", "text": [ "ipratropium bromide" ], "offsets": [ [ 33, 52 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009241" } ] }, { "id": "5115", "type": "Chemical", "text": [ "theophylline" ], "offsets": [ [ 57, 69 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013806" } ] }, { "id": "5116", "type": "Disease", "text": [ "chronic obstructive pulmonary disease" ], "offsets": [ [ 73, 110 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D029424" } ] }, { "id": "5117", "type": "Chemical", "text": [ "ipratropium bromide" ], "offsets": [ [ 159, 178 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009241" } ] }, { "id": "5118", "type": "Chemical", "text": [ "theophylline" ], "offsets": [ [ 220, 232 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013806" } ] }, { "id": "5119", "type": "Disease", "text": [ "chronic obstructive pulmonary disease" ], "offsets": [ [ 400, 437 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D029424" } ] }, { "id": "5120", "type": "Chemical", "text": [ "ipratropium" ], "offsets": [ [ 643, 654 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009241" } ] }, { "id": "5121", "type": "Chemical", "text": [ "theophylline" ], "offsets": [ [ 690, 702 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013806" } ] }, { "id": "5122", "type": "Chemical", "text": [ "ipratropium" ], "offsets": [ [ 781, 792 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009241" } ] }, { "id": "5123", "type": "Chemical", "text": [ "theophylline" ], "offsets": [ [ 804, 816 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013806" } ] }, { "id": "5124", "type": "Chemical", "text": [ "ipratropium" ], "offsets": [ [ 865, 876 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009241" } ] }, { "id": "5125", "type": "Chemical", "text": [ "theophylline" ], "offsets": [ [ 896, 908 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013806" } ] }, { "id": "5126", "type": "Chemical", "text": [ "theophylline" ], "offsets": [ [ 964, 976 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013806" } ] }, { "id": "5127", "type": "Disease", "text": [ "cardiovascular and gastrointestinal systems" ], "offsets": [ [ 997, 1040 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002318" }, { "db_name": "MESH", "db_id": "D005767" } ] }, { "id": "5128", "type": "Disease", "text": [ "cardiovascular", "systems" ], "offsets": [ [ 997, 1011 ], [ 1033, 1040 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002318" } ] }, { "id": "5129", "type": "Disease", "text": [ "gastrointestinal systems" ], "offsets": [ [ 1016, 1040 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005767" } ] }, { "id": "5130", "type": "Chemical", "text": [ "ipratropium" ], "offsets": [ [ 1066, 1077 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009241" } ] }, { "id": "5131", "type": "Chemical", "text": [ "theophylline" ], "offsets": [ [ 1120, 1132 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013806" } ] }, { "id": "5132", "type": "Disease", "text": [ "chronic airflow obstruction" ], "offsets": [ [ 1150, 1177 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D029424" } ] } ]

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[ { "id": "5133", "type": "CID", "arg1_id": "5115", "arg2_id": "5127", "normalized": [] }, { "id": "5134", "type": "CID", "arg1_id": "5115", "arg2_id": "5128", "normalized": [] }, { "id": "5135", "type": "CID", "arg1_id": "5118", "arg2_id": "5127", "normalized": [] }, { "id": "5136", "type": "CID", "arg1_id": "5118", "arg2_id": "5128", "normalized": [] }, { "id": "5137", "type": "CID", "arg1_id": "5121", "arg2_id": "5127", "normalized": [] }, { "id": "5138", "type": "CID", "arg1_id": "5121", "arg2_id": "5128", "normalized": [] }, { "id": "5139", "type": "CID", "arg1_id": "5123", "arg2_id": "5127", "normalized": [] }, { "id": "5140", "type": "CID", "arg1_id": "5123", "arg2_id": "5128", "normalized": [] }, { "id": "5141", "type": "CID", "arg1_id": "5125", "arg2_id": "5127", "normalized": [] }, { "id": "5142", "type": "CID", "arg1_id": "5125", "arg2_id": "5128", "normalized": [] }, { "id": "5143", "type": "CID", "arg1_id": "5126", "arg2_id": "5127", "normalized": [] }, { "id": "5144", "type": "CID", "arg1_id": "5126", "arg2_id": "5128", "normalized": [] }, { "id": "5145", "type": "CID", "arg1_id": "5131", "arg2_id": "5127", "normalized": [] }, { "id": "5146", "type": "CID", "arg1_id": "5131", "arg2_id": "5128", "normalized": [] }, { "id": "5147", "type": "CID", "arg1_id": "5115", "arg2_id": "5127", "normalized": [] }, { "id": "5148", "type": "CID", "arg1_id": "5115", "arg2_id": "5129", "normalized": [] }, { "id": "5149", "type": "CID", "arg1_id": "5118", "arg2_id": "5127", "normalized": [] }, { "id": "5150", "type": "CID", "arg1_id": "5118", "arg2_id": "5129", "normalized": [] }, { "id": "5151", "type": "CID", "arg1_id": "5121", "arg2_id": "5127", "normalized": [] }, { "id": "5152", "type": "CID", "arg1_id": "5121", "arg2_id": "5129", "normalized": [] }, { "id": "5153", "type": "CID", "arg1_id": "5123", "arg2_id": "5127", "normalized": [] }, { "id": "5154", "type": "CID", "arg1_id": "5123", "arg2_id": "5129", "normalized": [] }, { "id": "5155", "type": "CID", "arg1_id": "5125", "arg2_id": "5127", "normalized": [] }, { "id": "5156", "type": "CID", "arg1_id": "5125", "arg2_id": "5129", "normalized": [] }, { "id": "5157", "type": "CID", "arg1_id": "5126", "arg2_id": "5127", "normalized": [] }, { "id": "5158", "type": "CID", "arg1_id": "5126", "arg2_id": "5129", "normalized": [] }, { "id": "5159", "type": "CID", "arg1_id": "5131", "arg2_id": "5127", "normalized": [] }, { "id": "5160", "type": "CID", "arg1_id": "5131", "arg2_id": "5129", "normalized": [] } ]

[ { "id": "5162", "type": "title", "text": [ "Irreversible damage to the medullary interstitium in experimental analgesic nephropathy in F344 rats." ], "offsets": [ [ 0, 101 ] ] }, { "id": "5163", "type": "abstract", "text": [ "Renal papillary necrosis (RPN) and a decreased urinary concentrating ability developed during continuous long-term treatment with aspirin and paracetamol in female Fischer 344 rats. Renal structure and concentrating ability were examined after a recovery period of up to 18 weeks, when no analgesics were given, to investigate whether the analgesic-induced changes were reversible. There was no evidence of repair to the damaged medullary interstitial matrix, or proliferation of remaining undamaged type 1 medullary interstitial cells after the recovery period following analgesic treatment. The recovery of urinary concentrating ability was related to the length of analgesic treatment and the extent of the resulting inner medullary structural damage. During the early stages of analgesic treatment, the changes in urinary concentrating ability were reversible, but after prolonged analgesic treatment, maximum urinary concentrating ability failed to recover. This study shows that prolonged analgesic treatment in Fischer 344 rats causes progressive and irreversible damage to the interstitial matrix and type 1 interstitial cells leading to RPN. The associated urinary concentrating defect is reversible only during the early stages of structural damage to the inner medulla." ], "offsets": [ [ 102, 1382 ] ] } ]

[ { "id": "5164", "type": "Disease", "text": [ "nephropathy" ], "offsets": [ [ 76, 87 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "5165", "type": "Disease", "text": [ "Renal papillary necrosis" ], "offsets": [ [ 102, 126 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007681" } ] }, { "id": "5166", "type": "Disease", "text": [ "RPN" ], "offsets": [ [ 128, 131 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007681" } ] }, { "id": "5167", "type": "Chemical", "text": [ "aspirin" ], "offsets": [ [ 232, 239 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001241" } ] }, { "id": "5168", "type": "Chemical", "text": [ "paracetamol" ], "offsets": [ [ 244, 255 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000082" } ] }, { "id": "5169", "type": "Disease", "text": [ "RPN" ], "offsets": [ [ 1248, 1251 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007681" } ] } ]

[]

[]

[ { "id": "5170", "type": "CID", "arg1_id": "5168", "arg2_id": "5165", "normalized": [] }, { "id": "5171", "type": "CID", "arg1_id": "5168", "arg2_id": "5166", "normalized": [] }, { "id": "5172", "type": "CID", "arg1_id": "5168", "arg2_id": "5169", "normalized": [] }, { "id": "5173", "type": "CID", "arg1_id": "5167", "arg2_id": "5165", "normalized": [] }, { "id": "5174", "type": "CID", "arg1_id": "5167", "arg2_id": "5166", "normalized": [] }, { "id": "5175", "type": "CID", "arg1_id": "5167", "arg2_id": "5169", "normalized": [] } ]

[ { "id": "5177", "type": "title", "text": [ "Less frequent lithium administration and lower urine volume." ], "offsets": [ [ 0, 60 ] ] }, { "id": "5178", "type": "abstract", "text": [ "OBJECTIVE: This study was designed to determine whether patients maintained on a regimen of lithium on a once-per-day schedule have lower urine volumes than do patients receiving multiple doses per day. METHOD: This was a cross-sectional study of 85 patients from a lithium clinic who received different dose schedules. Patients were admitted to the hospital for measurement of lithium level, creatinine clearance, urine volume, and maximum osmolality. RESULTS: Multiple daily doses of lithium were associated with higher urine volumes. The dosing schedule, duration of lithium treatment, and daily dose of lithium did not affect maximum osmolality or creatinine clearance. CONCLUSIONS: Urine volume can be reduced by giving lithium once daily and/or by lowering the total daily dose. Lithium-induced polyuria seems to be related to extrarenal as well as to renal effects." ], "offsets": [ [ 61, 933 ] ] } ]

[ { "id": "5179", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 14, 21 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5180", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 153, 160 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5181", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 327, 334 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5182", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 439, 446 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5183", "type": "Chemical", "text": [ "creatinine" ], "offsets": [ [ 454, 464 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003404" } ] }, { "id": "5184", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 547, 554 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5185", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 631, 638 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5186", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 668, 675 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5187", "type": "Chemical", "text": [ "creatinine" ], "offsets": [ [ 713, 723 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003404" } ] }, { "id": "5188", "type": "Chemical", "text": [ "lithium" ], "offsets": [ [ 786, 793 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5189", "type": "Chemical", "text": [ "Lithium" ], "offsets": [ [ 846, 853 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D008094" } ] }, { "id": "5190", "type": "Disease", "text": [ "polyuria" ], "offsets": [ [ 862, 870 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011141" } ] } ]

[]

[]

[ { "id": "5191", "type": "CID", "arg1_id": "5179", "arg2_id": "5190", "normalized": [] }, { "id": "5192", "type": "CID", "arg1_id": "5180", "arg2_id": "5190", "normalized": [] }, { "id": "5193", "type": "CID", "arg1_id": "5181", "arg2_id": "5190", "normalized": [] }, { "id": "5194", "type": "CID", "arg1_id": "5182", "arg2_id": "5190", "normalized": [] }, { "id": "5195", "type": "CID", "arg1_id": "5184", "arg2_id": "5190", "normalized": [] }, { "id": "5196", "type": "CID", "arg1_id": "5185", "arg2_id": "5190", "normalized": [] }, { "id": "5197", "type": "CID", "arg1_id": "5186", "arg2_id": "5190", "normalized": [] }, { "id": "5198", "type": "CID", "arg1_id": "5188", "arg2_id": "5190", "normalized": [] }, { "id": "5199", "type": "CID", "arg1_id": "5189", "arg2_id": "5190", "normalized": [] } ]

[ { "id": "5201", "type": "title", "text": [ "Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues." ], "offsets": [ [ 0, 87 ] ] }, { "id": "5202", "type": "abstract", "text": [ "Thermal enhancement of Adriamycin-mediated antitumor activity and normal tissue toxicities by whole body hyperthermia were compared using a F344 rat model. Antitumor activity was studied using a tumor growth delay assay. Acute normal tissue toxicities (i.e., leukopenia and thrombocytopenia) and late normal tissue toxicities (i.e., myocardial and kidney injury) were evaluated by functional/physiological assays and by morphological techniques. Whole body hyperthermia (120 min at 41.5 degrees C) enhanced both Adriamycin-mediated antitumor activity and toxic side effects. The thermal enhancement ratio calculated for antitumor activity was 1.6. Thermal enhancement ratios estimated for \"acute\" hematological changes were 1.3, whereas those estimated for \"late\" damage (based on morphological cardiac and renal lesions) varied between 2.4 and 4.3. Thus, while whole body hyperthermia enhances Adriamycin-mediated antitumor effect, normal tissue toxicity is also increased, and the potential therapeutic gain of the combined modality treatment is eroded." ], "offsets": [ [ 88, 1143 ] ] } ]

[ { "id": "5203", "type": "Chemical", "text": [ "adriamycin" ], "offsets": [ [ 10, 20 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "5204", "type": "Disease", "text": [ "hyperthermia" ], "offsets": [ [ 46, 58 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005334" } ] }, { "id": "5205", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 62, 67 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "5206", "type": "Chemical", "text": [ "Adriamycin" ], "offsets": [ [ 111, 121 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "5207", "type": "Disease", "text": [ "toxicities" ], "offsets": [ [ 168, 178 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "5208", "type": "Disease", "text": [ "hyperthermia" ], "offsets": [ [ 193, 205 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005334" } ] }, { "id": "5209", "type": "Disease", "text": [ "tumor" ], "offsets": [ [ 283, 288 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009369" } ] }, { "id": "5210", "type": "Disease", "text": [ "toxicities" ], "offsets": [ [ 329, 339 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "5211", "type": "Disease", "text": [ "leukopenia" ], "offsets": [ [ 347, 357 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007970" } ] }, { "id": "5212", "type": "Disease", "text": [ "thrombocytopenia" ], "offsets": [ [ 362, 378 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013921" } ] }, { "id": "5213", "type": "Disease", "text": [ "toxicities" ], "offsets": [ [ 403, 413 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] }, { "id": "5214", "type": "Disease", "text": [ "myocardial and kidney injury" ], "offsets": [ [ 421, 449 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006331" }, { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "5215", "type": "Disease", "text": [ "myocardial", "injury" ], "offsets": [ [ 421, 431 ], [ 443, 449 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006331" } ] }, { "id": "5216", "type": "Disease", "text": [ "kidney injury" ], "offsets": [ [ 436, 449 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "5217", "type": "Disease", "text": [ "hyperthermia" ], "offsets": [ [ 545, 557 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005334" } ] }, { "id": "5218", "type": "Chemical", "text": [ "Adriamycin" ], "offsets": [ [ 600, 610 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "5219", "type": "Disease", "text": [ "cardiac and renal lesions" ], "offsets": [ [ 883, 908 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006331" }, { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "5220", "type": "Disease", "text": [ "cardiac", "lesions" ], "offsets": [ [ 883, 890 ], [ 901, 908 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006331" } ] }, { "id": "5221", "type": "Disease", "text": [ "renal lesions" ], "offsets": [ [ 895, 908 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007674" } ] }, { "id": "5222", "type": "Disease", "text": [ "hyperthermia" ], "offsets": [ [ 961, 973 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005334" } ] }, { "id": "5223", "type": "Chemical", "text": [ "Adriamycin" ], "offsets": [ [ 983, 993 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004317" } ] }, { "id": "5224", "type": "Disease", "text": [ "toxicity" ], "offsets": [ [ 1035, 1043 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D064420" } ] } ]

[]

[]

[ { "id": "5225", "type": "CID", "arg1_id": "5203", "arg2_id": "5214", "normalized": [] }, { "id": "5226", "type": "CID", "arg1_id": "5203", "arg2_id": "5215", "normalized": [] }, { "id": "5227", "type": "CID", "arg1_id": "5203", "arg2_id": "5219", "normalized": [] }, { "id": "5228", "type": "CID", "arg1_id": "5203", "arg2_id": "5220", "normalized": [] }, { "id": "5229", "type": "CID", "arg1_id": "5206", "arg2_id": "5214", "normalized": [] }, { "id": "5230", "type": "CID", "arg1_id": "5206", "arg2_id": "5215", "normalized": [] }, { "id": "5231", "type": "CID", "arg1_id": "5206", "arg2_id": "5219", "normalized": [] }, { "id": "5232", "type": "CID", "arg1_id": "5206", "arg2_id": "5220", "normalized": [] }, { "id": "5233", "type": "CID", "arg1_id": "5218", "arg2_id": "5214", "normalized": [] }, { "id": "5234", "type": "CID", "arg1_id": "5218", "arg2_id": "5215", "normalized": [] }, { "id": "5235", "type": "CID", "arg1_id": "5218", "arg2_id": "5219", "normalized": [] }, { "id": "5236", "type": "CID", "arg1_id": "5218", "arg2_id": "5220", "normalized": [] }, { "id": "5237", "type": "CID", "arg1_id": "5223", "arg2_id": "5214", "normalized": [] }, { "id": "5238", "type": "CID", "arg1_id": "5223", "arg2_id": "5215", "normalized": [] }, { "id": "5239", "type": "CID", "arg1_id": "5223", "arg2_id": "5219", "normalized": [] }, { "id": "5240", "type": "CID", "arg1_id": "5223", "arg2_id": "5220", "normalized": [] } ]

[ { "id": "5242", "type": "title", "text": [ "Prazosin-induced stress incontinence." ], "offsets": [ [ 0, 37 ] ] }, { "id": "5243", "type": "abstract", "text": [ "A case of genuine stress incontinence due to prazosin, a common antihypertensive drug, is presented. Prazosin exerts its antihypertensive effects through vasodilatation caused by selective blockade of postsynaptic alpha-1 adrenergic receptors. As an alpha-blocker, it also exerts a significant relaxant effect on the bladder neck and urethra. The patient's clinical course is described and correlated with initial urodynamic studies while on prazosin and subsequent studies while taking verapamil. Her incontinence resolved with the change of medication. The restoration of continence was accompanied by a substantial rise in maximum urethral pressure, maximum urethral closure pressure, and functional urethral length. Patients who present with stress incontinence while taking prazosin should change their antihypertensive medication before considering surgery, because their incontinence may resolve spontaneously with a change in drug therapy." ], "offsets": [ [ 38, 985 ] ] } ]

[ { "id": "5244", "type": "Chemical", "text": [ "Prazosin" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011224" } ] }, { "id": "5245", "type": "Disease", "text": [ "stress incontinence" ], "offsets": [ [ 17, 36 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014550" } ] }, { "id": "5246", "type": "Disease", "text": [ "stress incontinence" ], "offsets": [ [ 56, 75 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014550" } ] }, { "id": "5247", "type": "Chemical", "text": [ "prazosin" ], "offsets": [ [ 83, 91 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011224" } ] }, { "id": "5248", "type": "Chemical", "text": [ "Prazosin" ], "offsets": [ [ 139, 147 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011224" } ] }, { "id": "5249", "type": "Chemical", "text": [ "prazosin" ], "offsets": [ [ 480, 488 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011224" } ] }, { "id": "5250", "type": "Chemical", "text": [ "verapamil" ], "offsets": [ [ 525, 534 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014700" } ] }, { "id": "5251", "type": "Disease", "text": [ "incontinence" ], "offsets": [ [ 540, 552 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014549" } ] }, { "id": "5252", "type": "Disease", "text": [ "stress incontinence" ], "offsets": [ [ 784, 803 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014550" } ] }, { "id": "5253", "type": "Chemical", "text": [ "prazosin" ], "offsets": [ [ 817, 825 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011224" } ] }, { "id": "5254", "type": "Disease", "text": [ "incontinence" ], "offsets": [ [ 916, 928 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D014549" } ] } ]

[]

[]

[ { "id": "5255", "type": "CID", "arg1_id": "5244", "arg2_id": "5245", "normalized": [] }, { "id": "5256", "type": "CID", "arg1_id": "5244", "arg2_id": "5246", "normalized": [] }, { "id": "5257", "type": "CID", "arg1_id": "5244", "arg2_id": "5252", "normalized": [] }, { "id": "5258", "type": "CID", "arg1_id": "5247", "arg2_id": "5245", "normalized": [] }, { "id": "5259", "type": "CID", "arg1_id": "5247", "arg2_id": "5246", "normalized": [] }, { "id": "5260", "type": "CID", "arg1_id": "5247", "arg2_id": "5252", "normalized": [] }, { "id": "5261", "type": "CID", "arg1_id": "5248", "arg2_id": "5245", "normalized": [] }, { "id": "5262", "type": "CID", "arg1_id": "5248", "arg2_id": "5246", "normalized": [] }, { "id": "5263", "type": "CID", "arg1_id": "5248", "arg2_id": "5252", "normalized": [] }, { "id": "5264", "type": "CID", "arg1_id": "5249", "arg2_id": "5245", "normalized": [] }, { "id": "5265", "type": "CID", "arg1_id": "5249", "arg2_id": "5246", "normalized": [] }, { "id": "5266", "type": "CID", "arg1_id": "5249", "arg2_id": "5252", "normalized": [] }, { "id": "5267", "type": "CID", "arg1_id": "5253", "arg2_id": "5245", "normalized": [] }, { "id": "5268", "type": "CID", "arg1_id": "5253", "arg2_id": "5246", "normalized": [] }, { "id": "5269", "type": "CID", "arg1_id": "5253", "arg2_id": "5252", "normalized": [] } ]

[ { "id": "5271", "type": "title", "text": [ "Myocardial infarction following sublingual administration of isosorbide dinitrate." ], "offsets": [ [ 0, 82 ] ] }, { "id": "5272", "type": "abstract", "text": [ "A 78-year-old with healed septal necrosis suffered a recurrent myocardial infarction of the anterior wall following the administration of isosorbide dinitrate 5 mg sublingually. After detailing the course of events, we discuss the role of paradoxical coronary spasm and hypotension-mediated myocardial ischemia occurring downstream to significant coronary arterial stenosis in the pathophysiology of acute coronary insufficiency." ], "offsets": [ [ 83, 512 ] ] } ]

[ { "id": "5273", "type": "Disease", "text": [ "Myocardial infarction" ], "offsets": [ [ 0, 21 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "5274", "type": "Chemical", "text": [ "isosorbide dinitrate" ], "offsets": [ [ 61, 81 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007548" } ] }, { "id": "5275", "type": "Disease", "text": [ "necrosis" ], "offsets": [ [ 116, 124 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009336" } ] }, { "id": "5276", "type": "Disease", "text": [ "myocardial infarction" ], "offsets": [ [ 146, 167 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009203" } ] }, { "id": "5277", "type": "Chemical", "text": [ "isosorbide dinitrate" ], "offsets": [ [ 221, 241 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007548" } ] }, { "id": "5278", "type": "Disease", "text": [ "spasm" ], "offsets": [ [ 343, 348 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013035" } ] }, { "id": "5279", "type": "Disease", "text": [ "hypotension" ], "offsets": [ [ 353, 364 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D007022" } ] }, { "id": "5280", "type": "Disease", "text": [ "myocardial ischemia" ], "offsets": [ [ 374, 393 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017202" } ] }, { "id": "5281", "type": "Disease", "text": [ "coronary arterial stenosis" ], "offsets": [ [ 430, 456 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D023921" } ] }, { "id": "5282", "type": "Disease", "text": [ "acute coronary insufficiency" ], "offsets": [ [ 483, 511 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D054058" } ] } ]

[]

[]

[ { "id": "5283", "type": "CID", "arg1_id": "5274", "arg2_id": "5273", "normalized": [] }, { "id": "5284", "type": "CID", "arg1_id": "5274", "arg2_id": "5276", "normalized": [] }, { "id": "5285", "type": "CID", "arg1_id": "5277", "arg2_id": "5273", "normalized": [] }, { "id": "5286", "type": "CID", "arg1_id": "5277", "arg2_id": "5276", "normalized": [] } ]

[ { "id": "5288", "type": "title", "text": [ "Fluoxetine-induced akathisia: clinical and theoretical implications." ], "offsets": [ [ 0, 68 ] ] }, { "id": "5289", "type": "abstract", "text": [ "Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia. The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced akathisia. Three patients who had experienced neuroleptic-induced akathisia in the past reported that the symptoms of fluoxetine-induced akathisia were identical, although somewhat milder. Akathisia appeared to be a common side effect of fluoxetine and generally responded well to treatment with the beta-adrenergic antagonist propranolol, dose reduction, or both. The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced \"jitteriness\" may be identical." ], "offsets": [ [ 69, 1026 ] ] } ]

[ { "id": "5290", "type": "Chemical", "text": [ "Fluoxetine" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "5291", "type": "Disease", "text": [ "akathisia" ], "offsets": [ [ 19, 28 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017109" } ] }, { "id": "5292", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 93, 103 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "5293", "type": "Disease", "text": [ "obsessive compulsive disorder" ], "offsets": [ [ 125, 154 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D009771" } ] }, { "id": "5294", "type": "Disease", "text": [ "major depression" ], "offsets": [ [ 158, 174 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003865" } ] }, { "id": "5295", "type": "Disease", "text": [ "akathisia" ], "offsets": [ [ 185, 194 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017109" } ] }, { "id": "5296", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 208, 218 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "5297", "type": "Disease", "text": [ "anxiety" ], "offsets": [ [ 325, 332 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001008" } ] }, { "id": "5298", "type": "Disease", "text": [ "akathisia" ], "offsets": [ [ 390, 399 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017109" } ] }, { "id": "5299", "type": "Disease", "text": [ "akathisia" ], "offsets": [ [ 456, 465 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017109" } ] }, { "id": "5300", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 508, 518 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "5301", "type": "Disease", "text": [ "akathisia" ], "offsets": [ [ 527, 536 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017109" } ] }, { "id": "5302", "type": "Disease", "text": [ "Akathisia" ], "offsets": [ [ 579, 588 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017109" } ] }, { "id": "5303", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 628, 638 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "5304", "type": "Chemical", "text": [ "propranolol" ], "offsets": [ [ 717, 728 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D011433" } ] }, { "id": "5305", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 780, 790 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "5306", "type": "Disease", "text": [ "akathisia" ], "offsets": [ [ 799, 808 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017109" } ] }, { "id": "5307", "type": "Chemical", "text": [ "fluoxetine" ], "offsets": [ [ 929, 939 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D005473" } ] }, { "id": "5308", "type": "Disease", "text": [ "akathisia" ], "offsets": [ [ 948, 957 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D017109" } ] }, { "id": "5309", "type": "Chemical", "text": [ "antidepressant" ], "offsets": [ [ 972, 986 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D000928" } ] } ]

[]

[]

[ { "id": "5310", "type": "CID", "arg1_id": "5290", "arg2_id": "5291", "normalized": [] }, { "id": "5311", "type": "CID", "arg1_id": "5290", "arg2_id": "5295", "normalized": [] }, { "id": "5312", "type": "CID", "arg1_id": "5290", "arg2_id": "5298", "normalized": [] }, { "id": "5313", "type": "CID", "arg1_id": "5290", "arg2_id": "5299", "normalized": [] }, { "id": "5314", "type": "CID", "arg1_id": "5290", "arg2_id": "5301", "normalized": [] }, { "id": "5315", "type": "CID", "arg1_id": "5290", "arg2_id": "5302", "normalized": [] }, { "id": "5316", "type": "CID", "arg1_id": "5290", "arg2_id": "5306", "normalized": [] }, { "id": "5317", "type": "CID", "arg1_id": "5290", "arg2_id": "5308", "normalized": [] }, { "id": "5318", "type": "CID", "arg1_id": "5292", "arg2_id": "5291", "normalized": [] }, { "id": "5319", "type": "CID", "arg1_id": "5292", "arg2_id": "5295", "normalized": [] }, { "id": "5320", "type": "CID", "arg1_id": "5292", "arg2_id": "5298", "normalized": [] }, { "id": "5321", "type": "CID", "arg1_id": "5292", "arg2_id": "5299", "normalized": [] }, { "id": "5322", "type": "CID", "arg1_id": "5292", "arg2_id": "5301", "normalized": [] }, { "id": "5323", "type": "CID", "arg1_id": "5292", "arg2_id": "5302", "normalized": [] }, { "id": "5324", "type": "CID", "arg1_id": "5292", "arg2_id": "5306", "normalized": [] }, { "id": "5325", "type": "CID", "arg1_id": "5292", "arg2_id": "5308", "normalized": [] }, { "id": "5326", "type": "CID", "arg1_id": "5296", "arg2_id": "5291", "normalized": [] }, { "id": "5327", "type": "CID", "arg1_id": "5296", "arg2_id": "5295", "normalized": [] }, { "id": "5328", "type": "CID", "arg1_id": "5296", "arg2_id": "5298", "normalized": [] }, { "id": "5329", "type": "CID", "arg1_id": "5296", "arg2_id": "5299", "normalized": [] }, { "id": "5330", "type": "CID", "arg1_id": "5296", "arg2_id": "5301", "normalized": [] }, { "id": "5331", "type": "CID", "arg1_id": "5296", "arg2_id": "5302", "normalized": [] }, { "id": "5332", "type": "CID", "arg1_id": "5296", "arg2_id": "5306", "normalized": [] }, { "id": "5333", "type": "CID", "arg1_id": "5296", "arg2_id": "5308", "normalized": [] }, { "id": "5334", "type": "CID", "arg1_id": "5300", "arg2_id": "5291", "normalized": [] }, { "id": "5335", "type": "CID", "arg1_id": "5300", "arg2_id": "5295", "normalized": [] }, { "id": "5336", "type": "CID", "arg1_id": "5300", "arg2_id": "5298", "normalized": [] }, { "id": "5337", "type": "CID", "arg1_id": "5300", "arg2_id": "5299", "normalized": [] }, { "id": "5338", "type": "CID", "arg1_id": "5300", "arg2_id": "5301", "normalized": [] }, { "id": "5339", "type": "CID", "arg1_id": "5300", "arg2_id": "5302", "normalized": [] }, { "id": "5340", "type": "CID", "arg1_id": "5300", "arg2_id": "5306", "normalized": [] }, { "id": "5341", "type": "CID", "arg1_id": "5300", "arg2_id": "5308", "normalized": [] }, { "id": "5342", "type": "CID", "arg1_id": "5303", "arg2_id": "5291", "normalized": [] }, { "id": "5343", "type": "CID", "arg1_id": "5303", "arg2_id": "5295", "normalized": [] }, { "id": "5344", "type": "CID", "arg1_id": "5303", "arg2_id": "5298", "normalized": [] }, { "id": "5345", "type": "CID", "arg1_id": "5303", "arg2_id": "5299", "normalized": [] }, { "id": "5346", "type": "CID", "arg1_id": "5303", "arg2_id": "5301", "normalized": [] }, { "id": "5347", "type": "CID", "arg1_id": "5303", "arg2_id": "5302", "normalized": [] }, { "id": "5348", "type": "CID", "arg1_id": "5303", "arg2_id": "5306", "normalized": [] }, { "id": "5349", "type": "CID", "arg1_id": "5303", "arg2_id": "5308", "normalized": [] }, { "id": "5350", "type": "CID", "arg1_id": "5305", "arg2_id": "5291", "normalized": [] }, { "id": "5351", "type": "CID", "arg1_id": "5305", "arg2_id": "5295", "normalized": [] }, { "id": "5352", "type": "CID", "arg1_id": "5305", "arg2_id": "5298", "normalized": [] }, { "id": "5353", "type": "CID", "arg1_id": "5305", "arg2_id": "5299", "normalized": [] }, { "id": "5354", "type": "CID", "arg1_id": "5305", "arg2_id": "5301", "normalized": [] }, { "id": "5355", "type": "CID", "arg1_id": "5305", "arg2_id": "5302", "normalized": [] }, { "id": "5356", "type": "CID", "arg1_id": "5305", "arg2_id": "5306", "normalized": [] }, { "id": "5357", "type": "CID", "arg1_id": "5305", "arg2_id": "5308", "normalized": [] }, { "id": "5358", "type": "CID", "arg1_id": "5307", "arg2_id": "5291", "normalized": [] }, { "id": "5359", "type": "CID", "arg1_id": "5307", "arg2_id": "5295", "normalized": [] }, { "id": "5360", "type": "CID", "arg1_id": "5307", "arg2_id": "5298", "normalized": [] }, { "id": "5361", "type": "CID", "arg1_id": "5307", "arg2_id": "5299", "normalized": [] }, { "id": "5362", "type": "CID", "arg1_id": "5307", "arg2_id": "5301", "normalized": [] }, { "id": "5363", "type": "CID", "arg1_id": "5307", "arg2_id": "5302", "normalized": [] }, { "id": "5364", "type": "CID", "arg1_id": "5307", "arg2_id": "5306", "normalized": [] }, { "id": "5365", "type": "CID", "arg1_id": "5307", "arg2_id": "5308", "normalized": [] } ]

[ { "id": "5367", "type": "title", "text": [ "Chronic active hepatitis associated with diclofenac sodium therapy." ], "offsets": [ [ 0, 67 ] ] }, { "id": "5368", "type": "abstract", "text": [ "Diclofenac sodium (Voltarol, Geigy Pharmaceuticals) is a non-steroidal anti-inflammatory derivative of phenylacetic acid. Although generally well-tolerated, asymptomatic abnormalities of liver function have been recorded and, less commonly, severe hepatitis induced by diclofenac. The patient described developed chronic active hepatitis after six months therapy with diclofenac sodium which progressed despite the withdrawal of the drug, a finding not previously reported." ], "offsets": [ [ 68, 541 ] ] } ]

[ { "id": "5369", "type": "Disease", "text": [ "Chronic active hepatitis" ], "offsets": [ [ 0, 24 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006521" } ] }, { "id": "5370", "type": "Chemical", "text": [ "diclofenac sodium" ], "offsets": [ [ 41, 58 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004008" } ] }, { "id": "5371", "type": "Chemical", "text": [ "Diclofenac sodium" ], "offsets": [ [ 68, 85 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004008" } ] }, { "id": "5372", "type": "Chemical", "text": [ "Voltarol" ], "offsets": [ [ 87, 95 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004008" } ] }, { "id": "5373", "type": "Chemical", "text": [ "phenylacetic acid" ], "offsets": [ [ 171, 188 ] ], "normalized": [ { "db_name": "MESH", "db_id": "C025136" } ] }, { "id": "5374", "type": "Disease", "text": [ "abnormalities of liver function" ], "offsets": [ [ 238, 269 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "5375", "type": "Disease", "text": [ "hepatitis" ], "offsets": [ [ 316, 325 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D056486" } ] }, { "id": "5376", "type": "Chemical", "text": [ "diclofenac" ], "offsets": [ [ 337, 347 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004008" } ] }, { "id": "5377", "type": "Disease", "text": [ "chronic active hepatitis" ], "offsets": [ [ 381, 405 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D006521" } ] }, { "id": "5378", "type": "Chemical", "text": [ "diclofenac sodium" ], "offsets": [ [ 436, 453 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D004008" } ] } ]

[]

[]

[ { "id": "5379", "type": "CID", "arg1_id": "5370", "arg2_id": "5374", "normalized": [] }, { "id": "5380", "type": "CID", "arg1_id": "5370", "arg2_id": "5375", "normalized": [] }, { "id": "5381", "type": "CID", "arg1_id": "5371", "arg2_id": "5374", "normalized": [] }, { "id": "5382", "type": "CID", "arg1_id": "5371", "arg2_id": "5375", "normalized": [] }, { "id": "5383", "type": "CID", "arg1_id": "5372", "arg2_id": "5374", "normalized": [] }, { "id": "5384", "type": "CID", "arg1_id": "5372", "arg2_id": "5375", "normalized": [] }, { "id": "5385", "type": "CID", "arg1_id": "5376", "arg2_id": "5374", "normalized": [] }, { "id": "5386", "type": "CID", "arg1_id": "5376", "arg2_id": "5375", "normalized": [] }, { "id": "5387", "type": "CID", "arg1_id": "5378", "arg2_id": "5374", "normalized": [] }, { "id": "5388", "type": "CID", "arg1_id": "5378", "arg2_id": "5375", "normalized": [] } ]

[ { "id": "5390", "type": "title", "text": [ "Stroke associated with cocaine use." ], "offsets": [ [ 0, 35 ] ] }, { "id": "5391", "type": "abstract", "text": [ "We describe eight patients in whom cocaine use was related to stroke and review 39 cases from the literature. Among these 47 patients the mean (+/- SD) age was 32.5 +/- 12.1 years; 76% (34/45) were men. Stroke followed cocaine use by inhalation, intranasal, intravenous, and intramuscular routes. Intracranial aneurysms or arteriovenous malformations were present in 17 of 32 patients studied angiographically or at autopsy; cerebral vasculitis was present in two patients. Cerebral infarction occurred in 10 patients (22%), intracerebral hemorrhage in 22 (49%), and subarachnoid hemorrhage in 13 (29%). These data indicate that (1) the apparent incidence of stroke related to cocaine use is increasing; (2) cocaine-associated stroke occurs primarily in young adults; (3) stroke may follow any route of cocaine administration; (4) stroke after cocaine use is frequently associated with intracranial aneurysms and arteriovenous malformations; and (5) in cocaine-associated stroke, the frequency of intracranial hemorrhage exceeds that of cerebral infarction." ], "offsets": [ [ 36, 1093 ] ] } ]

[ { "id": "5392", "type": "Disease", "text": [ "Stroke" ], "offsets": [ [ 0, 6 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "5393", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 23, 30 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5394", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 71, 78 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5395", "type": "Disease", "text": [ "stroke" ], "offsets": [ [ 98, 104 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "5396", "type": "Disease", "text": [ "Stroke" ], "offsets": [ [ 239, 245 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "5397", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 255, 262 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5398", "type": "Disease", "text": [ "Intracranial aneurysms" ], "offsets": [ [ 333, 355 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002532" } ] }, { "id": "5399", "type": "Disease", "text": [ "arteriovenous malformations" ], "offsets": [ [ 359, 386 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001165" } ] }, { "id": "5400", "type": "Disease", "text": [ "cerebral vasculitis" ], "offsets": [ [ 461, 480 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020293" } ] }, { "id": "5401", "type": "Disease", "text": [ "Cerebral infarction" ], "offsets": [ [ 510, 529 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002544" } ] }, { "id": "5402", "type": "Disease", "text": [ "intracerebral hemorrhage" ], "offsets": [ [ 561, 585 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002543" } ] }, { "id": "5403", "type": "Disease", "text": [ "subarachnoid hemorrhage" ], "offsets": [ [ 603, 626 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D013345" } ] }, { "id": "5404", "type": "Disease", "text": [ "stroke" ], "offsets": [ [ 695, 701 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "5405", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 713, 720 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5406", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 744, 751 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5407", "type": "Disease", "text": [ "stroke" ], "offsets": [ [ 763, 769 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "5408", "type": "Disease", "text": [ "stroke" ], "offsets": [ [ 808, 814 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "5409", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 839, 846 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5410", "type": "Disease", "text": [ "stroke" ], "offsets": [ [ 867, 873 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "5411", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 880, 887 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5412", "type": "Disease", "text": [ "intracranial aneurysms" ], "offsets": [ [ 922, 944 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002532" } ] }, { "id": "5413", "type": "Disease", "text": [ "arteriovenous malformations" ], "offsets": [ [ 949, 976 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D001165" } ] }, { "id": "5414", "type": "Chemical", "text": [ "cocaine" ], "offsets": [ [ 989, 996 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D003042" } ] }, { "id": "5415", "type": "Disease", "text": [ "stroke" ], "offsets": [ [ 1008, 1014 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020521" } ] }, { "id": "5416", "type": "Disease", "text": [ "intracranial hemorrhage" ], "offsets": [ [ 1033, 1056 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D020300" } ] }, { "id": "5417", "type": "Disease", "text": [ "cerebral infarction" ], "offsets": [ [ 1073, 1092 ] ], "normalized": [ { "db_name": "MESH", "db_id": "D002544" } ] } ]

[]

[]

[ { "id": "5418", "type": "CID", "arg1_id": "5393", "arg2_id": "5402", "normalized": [] }, { "id": "5419", "type": "CID", "arg1_id": "5394", "arg2_id": "5402", "normalized": [] }, { "id": "5420", "type": "CID", "arg1_id": "5397", "arg2_id": "5402", "normalized": [] }, { "id": "5421", "type": "CID", "arg1_id": "5405", "arg2_id": "5402", "normalized": [] }, { "id": "5422", "type": "CID", "arg1_id": "5406", "arg2_id": "5402", "normalized": [] }, { "id": "5423", "type": "CID", "arg1_id": "5409", "arg2_id": "5402", "normalized": [] }, { "id": "5424", "type": "CID", "arg1_id": "5411", "arg2_id": "5402", "normalized": [] }, { "id": "5425", "type": "CID", "arg1_id": "5414", "arg2_id": "5402", "normalized": [] }, { "id": "5426", "type": "CID", "arg1_id": "5393", "arg2_id": "5403", "normalized": [] }, { "id": "5427", "type": "CID", "arg1_id": "5394", "arg2_id": "5403", "normalized": [] }, { "id": "5428", "type": "CID", "arg1_id": "5397", "arg2_id": "5403", "normalized": [] }, { "id": "5429", "type": "CID", "arg1_id": "5405", "arg2_id": "5403", "normalized": [] }, { "id": "5430", "type": "CID", "arg1_id": "5406", "arg2_id": "5403", "normalized": [] }, { "id": "5431", "type": "CID", "arg1_id": "5409", "arg2_id": "5403", "normalized": [] }, { "id": "5432", "type": "CID", "arg1_id": "5411", "arg2_id": "5403", "normalized": [] }, { "id": "5433", "type": "CID", "arg1_id": "5414", "arg2_id": "5403", "normalized": [] }, { "id": "5434", "type": "CID", "arg1_id": "5393", "arg2_id": "5401", "normalized": [] }, { "id": "5435", "type": "CID", "arg1_id": "5393", "arg2_id": "5417", "normalized": [] }, { "id": "5436", "type": "CID", "arg1_id": "5394", "arg2_id": "5401", "normalized": [] }, { "id": "5437", "type": "CID", "arg1_id": "5394", "arg2_id": "5417", "normalized": [] }, { "id": "5438", "type": "CID", "arg1_id": "5397", "arg2_id": "5401", "normalized": [] }, { "id": "5439", "type": "CID", "arg1_id": "5397", "arg2_id": "5417", "normalized": [] }, { "id": "5440", "type": "CID", "arg1_id": "5405", "arg2_id": "5401", "normalized": [] }, { "id": "5441", "type": "CID", "arg1_id": "5405", "arg2_id": "5417", "normalized": [] }, { "id": "5442", "type": "CID", "arg1_id": "5406", "arg2_id": "5401", "normalized": [] }, { "id": "5443", "type": "CID", "arg1_id": "5406", "arg2_id": "5417", "normalized": [] }, { "id": "5444", "type": "CID", "arg1_id": "5409", "arg2_id": "5401", "normalized": [] }, { "id": "5445", "type": "CID", "arg1_id": "5409", "arg2_id": "5417", "normalized": [] }, { "id": "5446", "type": "CID", "arg1_id": "5411", "arg2_id": "5401", "normalized": [] }, { "id": "5447", "type": "CID", "arg1_id": "5411", "arg2_id": "5417", "normalized": [] }, { "id": "5448", "type": "CID", "arg1_id": "5414", "arg2_id": "5401", "normalized": [] }, { "id": "5449", "type": "CID", "arg1_id": "5414", "arg2_id": "5417", "normalized": [] } ]