text: Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.
  A series of novel 5-(benzyloxy)pyridin-2(1H)-ones were designed, synthesized and biologically evaluated for c-Met inhibition. Various amides and benzoimidazoles at C-3 position were investigated. A potent compound 12b with a c-Met IC50 of 12nM was identified. This compound exhibited potent inhibition of EBC-1 cell associated with c-Met constitutive activation and showed high selectivity for c-Met than other tested 11 kinases. The binding model 12b with c-Met was disclosed by docking analysis.
entities.id: T10 T11 T1 T2 T3 T4 T5 T6 T7 T8 T9
entities.type: GENE-Y GENE-Y CHEMICAL CHEMICAL CHEMICAL CHEMICAL GENE-Y GENE-Y GENE-Y GENE-Y GENE-N
entities.text: c-Met c-Met amides benzoimidazoles 5-(benzyloxy)pyridin-2(1H)-ones 5-(benzyloxy)pyridin-2(1H)-one c-Met c-Met c-Met c-Met kinases