text: Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight.
  The current report describes progress in development of a selective thyroid hormone receptor modulator, GC-1. This compound binds selectively to the beta-isoform of the thyroid hormone receptor, and its uptake into the heart is relatively low. Studies in rats, mice and monkeys show that GC-1 lowers cholesterol with 600- to 1400-fold more potency and approximately two- to threefold more efficacy than atorvastatin, a compound that blocks HMG-CoA reductase. GC-1 also decreases plasma levels of triglyceride and lipoprotein (a), and induces loss of fat. These effects can be observed under conditions where there is either no or minimal effect on heart rate, and no detectable loss of muscle. Although more study is required, compounds of this class deserve further investigation for treating lipid disorders and obesity.
entities.id: T10 T11 T12 T1 T2 T3 T4 T5 T6 T7 T8 T9
entities.type: GENE-Y GENE-N GENE-N CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL GENE-Y
entities.text: HMG-CoA reductase lipoprotein (a) thyroid hormone receptor thyroid hormone cholesterol atorvastatin HMG-CoA triglyceride thyroid hormone thyroid hormone cholesterol beta-isoform of the thyroid hormone receptor