text: Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: discovery of a potential clinical candidate for treatment of methamphetamine abuse.
  A series of N-substituted lobelane analogues was synthesized and evaluated for their [(3)H]dihydrotetrabenazine binding affinity at the vesicular monoamine transporter and for their inhibition of vesicular [(3)H]dopamine uptake. Compound 19a, which contains an N-1,2(R)-dihydroxypropyl group, had been identified as a potential clinical candidate for the treatment of methamphetamine abuse.
entities.id: T10 T11 T12 T1 T2 T3 T4 T5 T6 T7 T8 T9
entities.type: CHEMICAL GENE-N GENE-Y CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL CHEMICAL
entities.text: nor-lobelane vesicular monoamine transporter VMAT2 N monoamine [(3)H]dopamine N-1,2(R)-dihydroxypropyl lobelane methamphetamine [(3)H]dihydrotetrabenazine methamphetamine N