Classroom Activities for Teaching Sedimentary GeologyThis collection of teaching materials allows for the sharing of ideas and activities within the community of geoscience teachers. Do you have a favorite teaching activity you'd like to share? Please help us expand this collection by contributing your own teaching materials.
Subject: Sedimentary Geology
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Chemical and Physical Weathering Field and Lab Experiment: Development and Testing of Hypotheses part of Activities
Lisa Greer, Washington and Lee University
This exercise combines an integrated field and laboratory experiment with a significant scientific writing assignment to address chemical and physical weathering processes via hypothesis development, experimental ...
Demystifying the Equations of Sedimentary Geology part of Activities
Larry Lemke, Wayne State University
This activity includes three strategies to help students develop a deeper comfort level and stronger intuitive sense for understanding mathematical expressions commonly encountered in sedimentary geology. Each can ...
Digital Sandstone Tutorial part of Activities
Kitty Milliken, University of Texas at Austin, The
The Tutorial Petrographic Image Atlas is designed to give students more exposure to petrographic features than they can get during organized laboratory periods.
Red rock and concretion models from Earth to Mars: Teaching diagenesis part of Activities
Margie Chan, University of Utah
This activity teaches students concepts of terrestrial diagenesis (cementation, fluid flow, porosity and permeability, concretions) and encourages them to apply those concepts to new or unknown settings, including ...


In 1962 President John F. Kennedy’s administration narrowly averted possible nuclear war with the USSR, when CIA operatives spotted Soviet surface-to-surface missiles in Cuba, after a six-week gap in intelligence-gathering flights.
In their forthcoming book Blind over Cuba: The Photo Gap and the Missile Crisis, co-authors David Barrett and Max Holland make the case that the affair was a close call stemming directly from a decision made in a climate of deep distrust between key administration officials and the intelligence community.
Using recently declassified documents, secondary materials, and interviews with several key participants, the authors weave a story of intra-agency conflict, suspicion, and discord that undermined intelligence-gathering, adversely affected internal postmortems conducted after the crisis peaked, and resulted in keeping Congress and the public in the dark about what really happened.
We asked Barrett, a professor of political science at Villanova University, to discuss the actual series of events and what might have happened had the CIA not detected Soviet missiles on Cuba.
The Actual Sequence of Events . . .
“Some months after the Cuban Missile Crisis, an angry member of the Armed Services Committee of the House of Representatives criticized leaders of the Kennedy administration for having let weeks go by in September and early October 1962, without detecting Soviet construction of missile sites in Cuba. It was an intelligence failure as serious as the U.S. ignorance that preceded the Japanese attack on Pearl Harbor in 1941, he said.
Secretary of Defense Robert McNamara aggressively denied that there had been an American intelligence failure or ineptitude with regard to Cuba in late summer 1962. McNamara and others persuaded most observers the administration’s performance in the lead-up to the Crisis had been almost flawless, but the legislator was right: The CIA had not sent a U-2 spy aircraft over western Cuba for about a six week period.
There were varying reasons for this, but the most important was that the Kennedy administration did not wish to have a U-2 “incident.” Sending that aircraft over Cuba raised the possibility that Soviet surface-to-air missiles might shoot one down. Since it was arguably against international law for the U.S. to send spy aircrafts over another country, should one be shot down, there would probably be the same sort of uproar as happened in May 1960, when the Soviet Union shot down an American U-2 flying over its territory.
Furthermore, most State Department and CIA authorities did not believe that the USSR would put nuclear-armed missiles into Cuba that could strike the U.S. Therefore, the CIA was told, in effect, not even to request permission to send U-2s over western Cuba. This, at a time when there were growing numbers of reports from Cuban exiles and other sources about suspicious Soviet equipment being brought into the country.As we now know, the Soviets WERE constructing missile sites on what CIA deputy director Richard Helms would call “the business end of Cuba,” i.e., the western end, in the summer/autumn of 1962. Fortunately, by mid-October, the CIA’s director, John McCone, succeeded in persuading President John F. Kennedy to authorize one U-2 flight over that part of Cuba and so it was that Agency representatives could authoritatively inform JFK on October 16th that the construction was underway.The CIA had faced White House and State Department resistance for many weeks about this U-2 matter."
What Could Have Happened . . .
“What if McCone had not succeeded in persuading the President that the U.S. needed to step up aerial surveillance of Cuba in mid-October? What if a few more weeks had passed without that crucial October 14 U-2 flight and its definitive photography of Soviet missile site construction?
Remember to check out Blind over Cuba: The Photo Gap and the Missile Crisis, which is being published this fall!If McCone had been told “no” in the second week of October, perhaps it would have taken more human intelligence, trickling in from Cuba, about such Soviet activity before the President would have approved a risky U-2 flight.The problem JFK would have faced then is that there would have been a significant number of operational medium-range missile launch sites. Those nuclear-equipped missiles could have hit the southern part of the U.S. Meanwhile, the Soviets would also have progressed further in construction of intermediate missile sites; such missiles could have hit most of the continental United States.If JFK had not learned about Soviet nuclear-armed missiles until, say, November 1st, what would the U.S. have done?There is no definitive answer to that question, but I think it’s fair to say that the President would have been under enormous pressure to authorize—quickly--a huge U.S. air strike against Cuba, followed by an American invasion. One thing which discovery of the missile sites in mid-October gave JFK was some time to negotiate effectively with the Soviet Union during the “Thirteen Days” of the crisis. I don’t think there would have been such a luxury if numerous operational missiles were discovered a couple weeks later.No wonder President Kennedy felt great admiration and gratitude toward those at the CIA (with its photo interpreters) and the Air Force (which piloted the key U-2 flight). The intelligence he received on October 16th was invaluable. I think he knew that if that intelligence had not come until some weeks later, there would have been a much greater chance of nuclear war between the U.S. and the Soviet Union.”


By JOHN CARTER
When Abraham Lincoln died from an assassin’s bullet on April 15, 1865, Edwin Stanton remarked to those gathered around his bedside, “Now he belongs to the ages.”
One of the meanings implied in Stanton’s famous statement is that Lincoln would not only be remembered as an iconic figure of the past, but that his spirit would also play a significant role in ages to come.
The Oscar-nominated movie “Lincoln,” which chronicles the struggle to pass the 13th amendment abolishing slavery, has turned our attention again to Lincoln’s legacy and his relevance amid our nation’s present divisions and growing pains.
Here is some of the wit and wisdom of Abraham Lincoln worth pondering:
“As for being president, I feel like the man who was tarred and feathered and ridden out of town on a rail. To the man who asked him how he liked it, he said, ‘If it wasn’t for the honor of the thing, I’d rather walk.’”
“I desire so to conduct the affairs of this administration that if at the end, when I come to lay down the reins of power, I have lost every other friend on earth, I shall at least have one friend left, and that friend shall be down inside of me.”
“Should my administration prove to be a very wicked one, or what is more probable, a very foolish one, if you the people are true to yourselves and the Constitution, there is but little harm I can do, thank God.”
“Bad promises are better broken than kept.”
“I am not at all concerned that the Lord is on our side in this great struggle, for I know that the Lord is always on the side of the right; but it is my constant anxiety and prayer that I and this nation may be on the Lord’s side.”
“I have never had a feeling, politically, that did not spring from the sentiments embodied in the Declaration of Independence.”
“Those who deny freedom to others deserve it not for themselves; and, under a just God, cannot long retain it.”
“As I would not be a slave, so I would not be a master. This expresses my idea of democracy.”
“The probability that we may fail in the struggle ought not to deter us from the support of a cause we believe to be just.”
“The true rule, in determining to embrace or reject anything, is not whether it have any evil in it, but whether it have more evil than good. There are few things wholly evil or wholly good.”
“Some of our generals complain that I impair discipline and subordination in the army by my pardons and respites, but it makes me rested, after a hard day’s work, if I can find some good excuse for saving a man’s life, and I go to bed happy as I think how joyful the signing of my name will make him (a deserter) and his family.”
“I have been driven many times to my knees by the overwhelming conviction that I had nowhere else to go.”
In addition, Lincoln’s Gettysburg Address and his second inaugural speech are ever relevant. And you may wish to add your own favorites to these.
Paul’s advice to us in Philippians 4:8 is to “fill your minds with those things that are good and deserve praise: things that are true, noble, right, pure, lovely, and honorable.”
As we celebrate his birthday on the 12th, Lincoln’s words more than meet this standard!
John Carter is a Weatherford resident whose column, “Notes From the Journey,” is published weekly in the Weatherford Democrat.


Science Fair Project Encyclopedia
The chloride ion is formed when the element chlorine picks up one electron to form the anion (negatively charged ion) Cl−. The salts of hydrochloric acid HCl contain chloride ions and are also called chlorides. An example is table salt, which is sodium chloride with the chemical formula NaCl. In water, it dissolves into Na+ and Cl− ions.
The word chloride can also refer to a chemical compound in which one or more chlorine atoms are covalently bonded in the molecule. This means that chlorides can be either inorganic or organic compounds. The simplest example of an inorganic covalently bonded chloride is hydrogen chloride, HCl. A simple example of an organic covalently bonded chloride is chloromethane (CH3Cl), often called methyl chloride.
Other examples of inorganic covalently bonded chlorides which are used as reactants are:
- phosphorus trichloride, phosphorus pentachloride, and thionyl chloride - all three are reactive chlorinating reagents which have been used in a laboratory.
- Disulfur dichloride (SCl2) - used for vulcanization of rubber.
Chloride ions have important physiological roles. For instance, in the central nervous system the inhibitory action of glycine and some of the action of GABA relies on the entry of Cl− into specific neurons.
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details


How do you get HIV?
HIV can be passed on when infected bodily fluid, such as blood or semen, is passed into an uninfected person. Semen is the liquid which is released from a man's penis during sex which carries sperm. It can be infected with HIV or AIDS when someone is HIV positive or is carrying the AIDS virus. This can happen during unprotected sex. For example when two people have sex without using a condom when one partner is already infected, or between drug users who inject and share needles.
It can't be transmitted by things like coughing, sneezing, kissing, sharing a toilet seat, swimming pools, sweat and tears.


Brain Matures a Few Years Late in ADHD
but Follows Normal Pattern
A 2007 press release from the National Institute of Mental Health discusses brain development in ADHD youths. In some cases, brain development is delayed as much as three years. The full release and related video are available on the NIMH site: Brain Matures a Few Years Late in ADHD, but Follows Normal Pattern.
Autistic Spectrum Disorders (ASD):
How to Help Children with Autism Learn
From Dr. Lauer and Dr. Beaulieu's talk
Quick facts about Pervasive Developmental Disorders (PDD)/ Autistic Spectrum Disorders (ASD)
- Autism is a 'spectrum disorder' meaning that it affects children in different ways and at different times in their development.
- Typically, delays and learning problems can emerge in several areas of functioning including social functioning, communication skills, motor skills, and overall intellectual potential.
- Each child has their own learning style that includes specific learning challenges as well as areas of preserved skills and, at times, exceptional abilities.
- Both autism and Asperger's disorder are on the same continuum but are distinct in their expression.
What are the challenges students with PDD/ASD frequently experience?
- Academic difficulties that can often be misinterpreted as learning disabilities.
- Problems with executive functioning skills.
- Difficulty in forming relationships with peers.
- Emotional difficulties due to learning and social problems such as anxiety, depression, low self-esteem.
- Fear of new situations and trouble adjusting to changes.
- May look like or be misconstrued as attention-deficit-hyperactivity disorder (ADHD), Nonverbal Learning Disability (NLD), Oppositional-Defiant Disorder or Obsessive Compulsive Disorder (OCD).
Why choose US to help YOU?
- Our evaluations are conducted by neuropsychologists who have been extensively trained in the early detection of autistic spectrum disorders and in the identification of specific patterns of learning strengths and weaknesses that are often associated with this condition.
- Our evaluations help determine which teaching style is best suited to fit an individuals' specific learning profile; we also offer suggestions regarding compensatory educational approached.
- We work as a team with other learning professionals, advocates and health professionals to enhance the child's potential for success in all settings.
'The design of truly individual treatment plans that exploit strengths and compensate for weaknesses begins with a detailed understanding of how learning is different for children with autism than for those without autism and how learning is different among children with autism.'
— Bryna Siegel, Ph.D., author of Helping Children with Autism Learn
For more information on current research, interventions and programs, follow us on Facebook.
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Download source - 8 Kb
This tutorial is based off of the MSDN Article #ID: Q194873. But, for a beginner, following these MSDN articles can be intimidating to say the least. One of the most often asked questions I see as a Visual C++ and Visual Basic programmer is how to call a VB DLL from VC++. Well, I am hoping to show you exactly that today. I am not going to go over the basic details of COM as this would take too long, so I am assuming you have an understanding of VB, VC++ and a little COM knowledge. It's not too hard to learn; just takes a little time. So let's get started.
The first thing you need to do is fire up Visual Basic 6 (VB 5 should work as well). With VB running, create a new "ActiveX DLL" project. Rename the project to "vbTestCOM" and the class to "clsTestClass". You can do this by clicking in the VB Project Explorer Window on the Project1 item (Step 1), then clicking in the Properties window and selecting the name property (Step 2). Do the same for the Class. Click on the class (Step 3), then the name property and enter the name mentioned above (Step 4). Your project so far should look like the folowing right hand side picture:
Ok, now we are ready to add some code to the VB Class. Click on the "Tools" menu, then select the "Add Procedure" menu item. The Add Procedure window will open up. In this window we need to add some information. First (Step 1) make sure the type is set to Function. Second (Step 2) enter a Function name called "CountStringLength". Finally hit the Ok button and VB will generate the new function in the class.
You should have an empty function with which to work. The first thing we will do is specify a return type and an input parameter. Edit your code to look like this:
Public Function CountStringLength(ByVal strValue As String) As Long
What are we doing here? We are taking one parameter, as a String type in this case, then returning the length through the return type, which is a Long. We specify the input parameter as ByVal, meaning VB will make a copy of this variable and use the copy in the function, rather than the default ByRef, which passes the variable by reference. This way we can be sure that we do not modify the string by accident that was passed to us by the calling program. Let's add the code now.
Public Function CountStringLength(ByVal strValue As String) As Long
If strValue = vbNullString Then
CountStringLength = 0
CountStringLength = Len(strValue)
In the first line of code we are checking to see if the calling program passed us an empty, or NULL, string. If so we return 0 as the length. If the user did pass something other than an empty string, then we count it's length and return the length back to the calling program.
Now would be a good time to save your project. Accept the default names and put it in a safe directory. We need to compile this project now. Go to the File menu and select the "Make vbCOMTest.dll..." menu item.
The compiler will produce a file called surprisingly enough: vbCOMTest.dll. The compiler will also do us the favor of entering this new DLL into the system registry. We have finished the VB side of this project, so let's start the VC++ side of it. Fire up a copy of VC++, then select from the menu, "New Project". The New Project window should appear. Select a "Win32 Console Application" (Step 1), then give it a name of "TestVBCOM" (Step 2). Finally, enter a directory you want to build this project in (Step 3 - your directory will vary from what I have entered).
Click on the "OK" button and the "Win32 Console Application - Step 1 of 1" window will appear. Leave everything on this page as the default, and click the "Finish" button. One final window will appear after this titled "New Project Information". Simply click the "Ok" button here. You should now have an empty Win32 Console project. Press the "Ctrl" and hit the "N" key. Another window titled "New" will appear. Select the "C++ Source File" (Step 1), then enter the new name for this file called, "TestVBCOM.cpp" (Step 2 - make sure the Add to Project checkbox is checked and the correct project name is in the drop down combo box), then click the "Ok" button to finish.
Now we are going to get fancy!
You need to go to your Start Menu in Windows and navigate to the "Visual Studio 6" menu and go into the "Microsoft Visual Studio 6.0 Tools" sub-menu. In here you will see an icon with the name "OLE View". Click on it.
The OLE View tool will open up. You will see a window similar to this one:
Collapse all the trees, if they are not already. This will make it easier to navigate to where we want to go. Highlight the "Type Libraries" (Step 1) and expand it. You should see a fairly massive listing. We need to locate our VB DLL. Now, remember what we named the project? Right, we need to look for vbTestCOM. Scroll down until you find this. Once you have found it, double click on it. A new window should appear - the "ITypeLib Viewer" window. We are only interested in the IDL (Interface Definition Language) code on the right side of the window. Select the entire IDL text and hit the "Ctrl" and "C" buttons to copy it to the clipboard.
You can close this window and the OLE View window now as we are done with the tool. We need to add the contents of the IDL file into our VC++ project folder. Go to the folder you told VC++ to create your project in and create a new text file there (If you are in Windows Explorer, you can right click in the directory and select "New" then scroll over following the arrow and select "Text Document"). Rename the text document to "vbCOMTEST.idl". Then double click on the new IDL file (VC++ should open it if you named it correctly with an IDL extension). Now paste the code in the file by pressing the "Ctrl" and "V" keys. The IDL text should be pasted into the file. So far, so good. Now, this IDL file is not going to do us much good until we compile it. That way, VC++ can use the files it generates to talk to the VB DLL. Let's do that now. Open a DOS window and navigate to the directory you created your VC++ project in. Once in that directory, at the prompt you need to type the following to invoke the MIDL compiler:
E:\VCSource\TestVBCOM\TestVBCOM\midl vbTestCOM.idl /h vbTestCOM.h
Hit the "Enter" key and let MIDL do its magic. You should see results similar to the following:
Close the DOS window and head back into VC++. We need to add the newly generated vbTestCOM.h and vbTestCOM_i.c files to the project. You can do this by going to the "Project" menu, then selecting the "Add to Project" item, and scrolling over to the "Files" menu item and clicking on it. A window titled, "Insert Files into Project" will open. Select the two files highlighted in the next picture, then select the "Ok" button.
These two files were generated by MIDL for us, and VC++ needs them in order to talk to the VB DLL (actually VC++ does not need the "vbCOMTest_i.c" file in the project, but it is handy have in the project to review). We are going to add the following code to the "TestVBCOM.cpp" file now, so navigate to that file in VC++ using the "Workspace" window. Open the file by double clicking it and VC++ will display the empty file for editing.
Now add the following code to the "TestVBCOM.cpp" file:
_clsVBTestClass *IVBTestClass = NULL;
hr = CoInitialize(0);
hr = CoCreateInstance( CLSID_clsVBTestClass,
_bstr_t bstrValue("Hello World");
hr = IVBTestClass->CountStringLength(bstrValue,
cout << "The string is: " << ReturnValue << " characters in
length." << endl;
hr = IVBTestClass->Release();
cout << "CoCreateInstance Failed." << endl;
If all the code is entered in correctly, then press the "F7" key to compile this project. Once the project has compiled cleanly, then press the "Ctrl" and the "F5" keys to run it. In the C++ code, we include the MIDL created "vbTestCOM.h" file, the "Comdef.h" file for the _bstr_t class support and the "iostream.h" file for the "cout" support. The rest of the comments should speak for themselves as to what's occurring. This simple tutorial shows how well a person can integrate VB and VC++ apps together using COM. Not too tough actually.


1854-89 THREE DOLLARS INDIAN HEAD
In 1853 the United States negotiated the "Gadsden Purchase"settlement of a boundary dispute with Mexico that resulted in the U.S. acquiring what would become the southern portions of Arizona and New Mexico for ten million dollars. The following year Commodore Matthew Perry embarked upon his famed expedition to re-open Japan to the Western world and establish trade. Spreading beyond its borders in many ways, a few years earlier the United States had joined the worldwide move to uniform postage rates and printed stamps when the Congressional Act of March 3, 1845 authorized the first U.S. postage stamps, and set the local prepaid letter rate at five cents. This set the stage for a close connection between postal and coinage history.
Exactly six years later, the postage rate was reduced to three cents when New York Senator Daniel S. Dickinson fathered legislation that simultaneously initiated coinage of the tiny silver three-cent piece as a public convenience. The large cents then in circulation were cumbersome and unpopular, and the new denomination was designed to facilitate the purchase of stamps without using the hated "coppers."
This reasoning was carried a step further when the Mint Act of February 21, 1853 authorized a three-dollar gold coin. Congress and Mint Director Robert Maskell Patterson were convinced that the new coin would speed purchases of three-cent stamps by the sheet and of the silver three-cent coins in roll quantities. Unfortunately, at no time during the 35-year span of this denomination did public demand justify these hopes. Chief Engraver James Barton Longacre chose an "Indian Princess" for his obverse not a Native American profile, but actually a profile modeled after the Greco-Roman Venus Accroupie statue then in a Philadelphia museum. Longacre used this distinctive sharp-nosed profile on his gold dollar of 1849 and would employ it again on the Indian Head cent of 1859. On the three-dollar coin Liberty is wearing a feathered headdress of equal-sized plumes with a band bearing LIBERTY in raised letters. She's surrounded by the inscription UNITED STATES OF AMERICA. Such a headdress dates back to the earliest known drawings of American Indians by French artist Jacques le Moyne du Morgue's sketches of the Florida Timucua tribe who lived near the tragic French colony of Fort Caroline in 1562. It was accepted by engravers and medalists of the day as the design shorthand for "America."
Longacre's reverse depicted a wreath of tobacco, wheat, corn and cotton with a plant at top bearing two conical seed masses. The original wax models of this wreath still exist on brass discs in a Midwestern collection and show how meticulous Longacre was in preparing his design. Encircled by the wreath is the denomination 3 DOLLARS and the date. There are two boldly different reverse types, the small DOLLARS appearing only in 1854 and the large DOLLARS on coins of 1855-89. Many dates show bold "outlining" of letters and devices, resembling a double strike but probably the result of excessive forcing of the design punches into the die steel, causing a hint of their sloping "shoulders" to appear as part of the coin's design. The high points of the obverse design that first show wear are the cheek and hair above the eye; on the reverse, check the bow knot and leaves.
A total of just over 535,000 pieces were issued along with 2058 proofs. The first coins struck were the 15 proofs of 1854. Regular coinage began on May 1, and that first year saw 138,618 pieces struck at Philadelphia (no mintmark), 1,120 at Dahlonega (D), and 24,000 at New Orleans (O). These two branch mints would strike coins only in 1854. San Francisco produced the three-dollar denomination in 1855, 1856, and 1857, again in 1860, and apparently one final piece in 1870. Mintmarks are found below the wreath.
Every U.S. denomination boasts a number of major rarities. The three-dollar gold coinage of 1854-1889 is studded with so many low-mintage dates that the entire series may fairly be called rare. In mint state 1878 is the most common date, followed by the 1879, 1888, 1854 and 1889 issues. Every other date is very rare in high grade, particularly 1858, 1865, 1873 Closed 3 and all the San Francisco issues. Minuscule mintages were the rule in the later years. Proof coins prior to 1859 are extremely rare and more difficult to find than the proof-only issues of 1873 Open 3, 1875 and 1876, but many dates are even rarer in the higher Mint State grades. This is because at least some proofs were saved by well- heeled collectors while few lower-budget collectors showed any interest in higher-grade business strikes of later-date gold. Counterfeits are known for many dates; any suspicious piece should be authenticated.
The rarest date of all is the unique 1870-S, of which only one example was struck for inclusion in the new Mint's cornerstone. Either the coin escaped, or a second was struck as a pocket piece for San Francisco Mint Coiner J.B. Harmstead. In any event, one coin showing traces of jewelry use surfaced in the numismatic market in 1907. It was sold to prominent collector William H. Woodin, and when Thomas L. Elder sold the Woodin collection in 1911, the coin went to Baltimore's Waldo C. Newcomer. Later owned by Virgil Brand, it was next sold by Ted and Carl Brandts of Ohio's Celina Coin Co. and Stack's of New York to Louis C. Eliasberg in 1946 for $11,500. In Bowers and Merena's October 1982 sale of the U.S. Gold Collection, this famous coin sold for a record $687,500.
The three-dollar denomination quietly expired in 1889 along with the gold dollar and nickel three-cent piece. America's coinage was certainly more prosaic without this odd denomination gold piece, but its future popularity with collectors would vastly outstrip the lukewarm public reception it enjoyed during its circulating life.


CTComms sends on average 2 million emails monthly on behalf of over 125 different charities and not for profits.
Take the complexity of technology and stir in the complexity of the legal system and what do you get? Software licenses! If you've ever attempted to read one you know how true this is, but you have to know a little about software licensing even if you can't parse all of the fine print.
By: Chris Peters
March 10, 2009
A software license is an agreement between you and the owner of a program which lets you perform certain activities which would otherwise constitute an infringement under copyright law. The software license usually answers questions such as:
The price of the software and the licensing fees, if any, are sometimes discussed in the licensing agreement, but usually it's described elsewhere.
If you read the definitions below and you're still scratching your head, check out Categories of Free and Non-Free Software which includes a helpful diagram.
Free vs Proprietary:
When you hear the phrase "free software" or "free software license," "free" is referring to your rights and permissions ("free as in freedom" or "free as in free speech"). In other words, a free software license gives you more rights than a proprietary license. You can usually copy, modify, and redistribute free software without paying a fee or obtaining permission from the developers and distributors. In most cases "free software" won't cost you anything, but that's not always the case – in this instance the word free is making no assertion whatsoever about the price of the software. Proprietary software puts more restrictions and limits on your legal permission to copy, modify, and distribute the program.
Free, Open-Source or FOSS?
In everyday conversation, there's not much difference between "free software," "open source software," and "FOSS (Free and Open-Source Software)." In other words, you'll hear these terms used interchangeably, and the proponents of free software and the supporters of open-source software agree with one another on most issues. However, the official definition of free software differs somewhat from the official definition of open-source software, and the philosophies underlying those definitions differ as well. For a short description of the difference, read Live and Let License. For a longer discussion from the "free software" side, read Why Open Source Misses the Point of Free Software. For the "open-source" perspective, read Why Free Software is Too Ambiguous.
Public domain and copyleft.
These terms refer to different categories of free, unrestricted licensing. A copyleft license allows you all the freedoms of a free software license, but adds one restriction. Under a copyleft license, you have to release any modifications under the same terms as the original software. In effect, this blocks companies and developers who want to alter free software and then make their altered version proprietary. In practice, almost all free and open-source software is also copylefted. However, technically you can release "free software" that isn't copylefted. For example, if you developed software and released it under a "public domain" license, it would qualify as free software, but it isn't copyleft. In effect, when you release something into the public domain, you give up all copyrights and rights of ownership.
Shareware and freeware.
These terms don't really refer to licensing, and they're confusing in light of the discussion of free software above. Freeware refers to software (usually small utilities at sites such as Tucows.com) that you can download and install without paying. However, you don't have the right to view the source code, and you may not have the right to copy and redistribute the software. In other words, freeware is proprietary software. Shareware is even more restrictive. In effect, shareware is trial software. You can use it for a limited amount of time (usually 30 or 60 days) and then you're expected to pay to continue using it.
End User Licensing Agreement (EULA).
When you acquire software yourself, directly from a vendor or retailer, or directly from the vendor's Web site, you usually have to indicate by clicking a box that you accept the licensing terms. This "click-through" agreement that no one ever reads is commonly known as a EULA. If you negotiate a large purchase of software with a company, and you sign a contract to seal the agreement, that contract usually replaces or supersedes the EULA.
Most major vendors of proprietary software offer some type of bulk purchasing and volume licensing mechanism. The terms vary widely, but if you order enough software to qualify, the benefits in terms of cost and convenience are significant. Also, not-for-profits sometimes qualify for it with very small initial purchases.
Some of the benefits of volume licensing include:
Lower cost. As with most products, software costs less when you buy more of it.
Ease of installation. Without volume licenses, you usually have to enter a separate activation code (also known as a product key or license key) for each installed copy of the program. On the other hand, volume licenses provide you with a single, organisation-wide activation code, which makes it much easier to find when you need to reinstall the software.
Easier tracking of licenses. Keeping track of how many licenses you own, and how many copies you've actually installed, is a tedious, difficult task. Many volume licensing programs provide an online account which is automatically updated when you obtain or activate a copy of that company's software. These accounts can also coordinate licensing across multiple offices within your organisation.
To learn more about volume licensing from a particular vendor, check out some of the resources below:
Qualified not-for-profits and libraries can receive donated volume licenses for Microsoft products through TechSoup. For more information, check out our introduction to the Microsoft Software Donation Program, and the Microsoft Software Donation Program FAQ. For general information about the volume licensing of Microsoft software, see Volume Licensing Overview.
If you get Microsoft software from TechSoup or other software distributors who work with not-for-profits, you may need to go to the eOpen Web site to locate your Volume license keys. For more information, check out the TechSoup Donation Recipient's Guide to the Microsoft eOpen Web Site.
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Pay close attention to the options and licensing requirements when you acquire server-based software. You might need two different types of license – one for the server software itself, and a set of licenses for all the "clients" accessing the software. Depending on the vendor and the licensing scenario, "client" can refer either to the end users themselves (for example, employees, contractors, clients, and anyone else who uses the software in question) or their computing devices (for example, laptops, desktop computers, smartphones, PDAs, etc.). We'll focus on Microsoft server products, but similar issues can arise with other server applications.
Over the years, Microsoft has released hundreds of server-based applications, and the licensing terms are slightly different for each one. Fortunately, there are common license types and licensing structures across different products. In other words, while a User CAL (Client Access License) for Windows Server is distinct from a User CAL for SharePoint Server, the underlying terms and rights are very similar. The TechSoup product pages for Microsoft software do a good job of describing the differences between products, so we'll focus on the common threads in this article.
Moreover, Microsoft often lets you license a single server application in more than one way, depending on the needs of your organisation. This allows you the flexibility to choose the licenses that best reflect your organisation's usage patterns and thereby cost you the least amount of money. For example, for Windows Server and other products you can acquire licenses on a per-user basis (for example, User CALs) or per-device basis (for example, Device CALs).
The license required to install and run most server applications usually comes bundled with the software itself. So you can install and run most applications "out of the box," as long as you have the right number of client licenses (see the section below for more on that). However, when you're running certain server products on a computer with multiple processors, you may need to get additional licenses. For example, if you run Windows Server 2008 DataCenter edition on a server with two processors, you need a separate license for each processor. SQL Server 2008 works the same way. This type of license is referred to as a processor license. Generally you don't need client licenses for any application that's licensed this way.
Client Licenses for Internal Users
Many Microsoft products, including Windows Server 2003 and Windows Server 2008, require client access licenses for all authenticated internal users (for example, employees, contractors, volunteers, etc.). On the other hand, SQL Server 2008 and other products don't require any client licenses. Read the product description at CTXchange if you're looking for the details about licensing a particular application.
User CALs: User CALs allow each user access to all the instances of a particular server product in an organisation, no matter which device they use to gain access. In other words, if you run five copies of Windows Server 2008 on five separate servers, you only need one User CAL for each person in your organisation who access those servers (or any software installed on those servers), whether they access a single server, all five servers, or some number in between. Each user with a single CAL assigned to them can access the server software from as many devices as they want (for example, desktop computers, laptops, smartphones, etc.). User CALs are a popular licensing option.
Device CALs: Device CALs allow access to all instances of a particular server application from a single device (for example, a desktop computer, a laptop, etc.) in your organisation. Device CALs only make sense when multiple employees use the same computer. For example, in 24-hour call centres different employees on different shifts often use the same machine, so Device CALs make sense in this situation.
Choosing a licensing mode for your Windows Server CALs: With Windows Server 2003 and Windows Server 2008, you use a CAL (either a User CAL or a Device CAL) in one of two licensing modes: per seat or per server. You make this decision when you're installing your Windows Server products, not when you acquire the CALs. The CALs themselves don't have any mode designation, so you can use either a User CAL or a Device CAL in either mode. Per seat mode is the default mode, and the one used most frequently. The description of User CALs and Device CALs above describes the typical per seat mode. In "per server" mode, Windows treats each license as a "simultaneous connection." In other words, if you have 40 CALs, Windows will let 40 authenticated users have access. The 41st user will be denied access. However, in per server mode, each CAL is tied to a particular instance of Windows Server, and you have to acquire a new set of licenses for each new server you build that runs Windows. Therefore, per server mode works for some small organisations with one or two servers and limited access requirements.
You don't "install" client licenses the way you install software. There are ways to automate the tracking of software licenses indirectly, but the server software can't refuse access to a user or device on licensing grounds. The licenses don't leave any "digital footprint" that the server software can read. An exception to this occurs when you license Windows Server in per server mode. In this case, if you have 50 licenses, the 51st authenticated user will be denied access (though anonymous users can still access services).
Some key points to remember about client licensing:
The licensing scenarios described in this section arise less frequently, and are too complex to cover completely in this article, so they're described briefly below along with more comprehensive resources.
You don't need client licenses for anonymous, unauthenticated external users. In other words, if someone accesses your Web site, and that site runs on Internet Information Server (IIS), Microsoft's Web serving software, you don't need a client license for any of those anonymous users.
If you have any authenticated external users who access services on your Windows-based servers, you can obtain CALs to cover their licensing requirements. However, the External Connector License (ECL) is a second option in this scenario. The ECL covers all use by authenticated external users, but it's a lot more expensive than a CAL, so only get one if you'll have a lot of external users. For example, even if you get your licenses through the CTXchange donation program, an ECL for Windows Server 2008 has an £76 administrative fee, while a User CAL for Windows Server 2008 carries a £1 admin fee. If only a handful of external users access your Windows servers, you're better off acquiring User CALs. Also, an ECL only applies to external users and devices. In other words, if you have an ECL, you still have to get a CAL for all employees and contractors.
Even though Terminal Services (TS) is built into Windows Server 2003 and 2008, you need to get a separate TS CAL for each client (i.e. each user or each device) that will access Terminal Services in your organisation. This TS license is in addition to your Windows Server CALs.
Microsoft's System Centre products (a line of enterprise-level administrative software packages) use a special type of license known as a management license (ML). Applications that use this type of licensing include System Center Configuration Manager 2007 and System Center Operations Manager 2007. Any desktop or workstation managed by one of these applications needs a client management license. Any server managed by one of these applications requires a server management license, and there are two types of server management licenses – standard and enterprise. You need one or the other but not both. There are also special licensing requirements if you're managing virtual instances of Windows operating systems. For more information, see TechSoup's Guide to System Center Products and Licensing and Microsoft's white paper on Systems Center licensing.
Some Microsoft server products have two client licensing modes, standard and enterprise. As you might imagine, an Enterprise CAL grants access to more advanced features of a product. Furthermore, with some products, such as Microsoft Exchange, the licenses are additive. In other words, a user needs both a Standard CAL AND an Enterprise CAL in order to access the advanced features. See Exchange Server 2007 Editions and Client Access Licenses for more information.
With virtualisation technologies, multiple operating systems can run simultaneously on a single physical server. Every time you install a Microsoft application, whether on a physical hardware system or a virtual hardware system, you create an "instance" of that application. The number of "instances" of particular application that you can run using a single license varies from product to product. For more information see the Volume Licensing Briefs, Microsoft Licensing for Virtualization and the Windows Server Virtualization Calculator. For TechSoup Stock products, see the product description for more information.
There are a lot of nuances to Microsoft licensing, and also a lot of excellent resources to help you understand different scenarios.
About the Author:
Chris is a former technology writer and technology analyst for TechSoup for Libraries, which aims to provide IT management guidance to libraries. His previous experience includes working at Washington State Library as a technology consultant and technology trainer, and at the Bill and Melinda Gates Foundation as a technology trainer and tech support analyst. He received his M.L.S. from the University of Michigan in 1997.
Originally posted here.
Copyright © 2009 CompuMentor. This work is published under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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Aliphatic alcohols occur
naturally in free form (component of the cuticular lipids) but more usually in esterified
(wax esters) or etherified form (glyceryl ethers). Several alcohols belong to aroma
compounds which are found in environmental or food systems (see the website: Flavornet).
They are found with normal, branched (mono- or isoprenoid), saturated or unsaturated of various chain length and sometimes with secondary or even tertiary alcoholic function. An unusual phenolic alcohol is found as a component of glycolipids in Mycobacteria. Some cyclic alcohols have been described in plants.
A classification according to the carbon-chain structure is given below.
1 - Normal-chain alcohols
The carbon chain may be fully saturated or unsaturated (with double and/or triple bonds), it may also be substituted with chlorine, bromine or sulfate groups. Some acetylenic alcohols have been also described.
Among the most common, some are listed below
9-methyl-1-hendecanol (anteisolauryl alcohol)
11-methyl-1-tridecanol (anteisomyristyl alcohol)
14-methyl-1-pentadecanol (isopalmityl alcohol)
13-methyl-1-pentadecanol (anteisopalmityl alcohol)
16-methyl-1-heptadecanol (isostearyl alcohol)
15-methyl-1-pentadecanol (anteisostearyl alcohol)
Free fatty alcohols are not commonly found in epicuticular lipids of insects, although high molecular weight alcohols have been reported in honeybees (Blomquist GJ et al., Insect Biochem 1980, 10, 313). Long-chain alcohols also have been reported in the defensive secretions of scale insects (Byrne DN et al., Physiol Entomol 1988, 13,267). Typically, insects more commonly produce lower molecular weight alcohols. Honeybees produce alcohols of 17–22 carbons, which induce arrestment in parasitic varroa mites (Donze G et al., Arch Insect Biochem Physiol 1998, 37, 129). Two female-specific fatty alcohols, docosanol (C22) and eicosanol (C20), which have been found in epicuticle of Triatoma infestans (a vector of Chagas disease in South America), are able to trigger copulation in males (Cocchiararo-Bastias L et al., J Chem Ecol 2011, 37, 246). Hexadecyl acetate is found in the web of some spiders (Pholcidae) to attract females (Schulz S, J Chem Ecol 2013, 39, 1).
Long-chain alcohols (C18, C24, C28) from the femoral glands in the male lizard Acanthodactylus boskianus play a role in chemical communication as a scent marking pheromone (Khannoon ER et al., Chemoecology 2011, 21, 143).
Various fatty alcohols are found in the waxy film that plants have over their leaves and fruits. Among them, octacosanol (C28:0) is the most frequently cited.
Policosanol is a natural mixture of higher primary aliphatic alcohols isolated and purified from sugar cane (Saccharum officinarum, L.) wax, whose main component is octacosanol but contains also hexacosanol (C26:0) and triacontanol or melissyl alcohol (C30:0). Policosanol is also extracted from a diversity of other natural sources such as beeswax, rice bran, and wheat germ (Irmak S et al., Food Chem 2006, 95, 312) but is also present in the fruits, leaves, and surfaces of plants and whole seeds. A complex policosanol mixture has been identified in peanut (Cherif AO et al., J Agric Food Chem 2010, 58, 12143). More than 20 aliphatic alcohols were identified (C14-C30) and four unsaturated alcohols (C20-24). The total policosanol content of the whole peanut samples varied from 11 to 54 mg/100 g of oil.
This mixture was shown to have cholesterol-lowering effects in rabbits (Arruzazabala ML et al., Biol Res 1994, 27, 205). Octacosanol was also able to suppress lipid accumulation in rats fed on a high-fat diet (Kato S et al., Br J Nutr 1995, 73, 433) and to inhibit platelet aggregation (Arruzazabala ML et al., Thromb Res 1993, 69, 321). The effectiveness of policosanol is still questionable but it has been approved as a cholesterol-lowering drug in over 25 countries (Carbajal D et al., Prostaglandins Leukotrienes Essent Fatty Acids 1998, 58, 61), and it is sold as a lipid-lowering supplement in more than 40 countries. More recent studies in mice question about any action on improvement of lipoprotein profiles (Dullens SPJ et al., J Lipid Res 2008, 49, 790). The authors conclude that individual policosanols, as well as natural policosanol mixtures, have no potential for reducing coronary heart disease risk through effects on serum lipoprotein concentrations. Furthermore, sugar cane policosanol at doses of 20 mg daily has shown no lipid lowering effects in subjects with primary hypercholesterolemia (Francini-Pesenti F et al., Phytother Res 2008, 22, 318). It must be noticed that, for the most part, positive results have been obtained by only one research group in Cuba. Outside Cuba, all groups have failed to validate the cholesterol-lowering efficacy of policosanols (Marinangeli C et al., Crit Rev Food Sci Nutr 2010, 50, 259). Independent studies are required before evaluating the exact value of the therapeutic benefits of that mixture.
An unsaturated analogue of octacosanol, octacosa-10, 19-dien-1-ol was synthesized and was as effective as policosanol in inhibiting the upregulation of HMGCoA reductase (Oliaro-Bosso S et al., Lipids 2009, 44, 907). This work opens promising perspectives for the design of new antiangiogenic compounds (Thippeswamy G et al., Eur J Pharmacol 2008, 588, 141). An unsaturated analogue of octacosanol, octacosa-10, 19-dien-1-ol was synthesized and was as effective as policosanol in inhibiting the upregulation of HMGCoA reductase (Oliaro-Bosso S et al., Lipids 2009, 44, 907). This work opens promising perspectives for the design of new antiangiogenic compounds.
1-Octanol and 3-octanol are components of the mushroom flavor (Maga JA, J Agric Food Chem 1981, 29, 1).
Many alcohols in the C10 to C18 range, and their short-chain acid esters are potent sex or aggregation pheromones. They are mainly found as components of specialized defensive glands, pheromone glands or glands of the reproductive system.
A series of C22 up to C28 saturated n-alcohols, with even carbon numbers predominating, and a maximum at C26 and C28, has been identified in the cyanobacterium Anabaena cylindrica (Abreu-Grobois FA et al., Phytochemistry 1977, 16, 351). Several authors have reported high contents of the 22:0 alcohol in sediments where an algal origin is plausible. For example, the major alcohol in a sample of the lacustrine Green River Shale of Eocene age is also 22:0 which comprises over 50% of the alcohols present (Sever JR et al., Science 1969, 164, 1052)
Long-chain alcohols are known as major surface lipid components (waxes) with chains from C20 up to C34 carbon atoms, odd carbon-chain alcohols being found in only low amounts. Very long-chain methyl-branched alcohols (C38 to C44) and their esters with short-chain acids were shown to be present in insects, mainly during metamorphosis. A series of long-chain alkanols (more than 23 carbon atoms) were identified in settling particles and surface sediments from Japanese lakes and were shown to be produced by planktonic bacteria being thus useful molecular markers (Fukushima K et al., Org Geochem 2005, 36, 311).
Cutin and suberin contain as monomer saturated alcohols from C16 to C22 up to 8% of the total polymers. C18:1 alcohol (oleyl alcohol) is also present.
Long-chain di-alcohols (1,3-alkanediols) have been described in the waxes which impregnate the matrix covering all organs of plants (Vermeer CP et al., Phytochemistry 2003, 62, 433). These compounds forming about 11% of the leaf cuticular waxes of Ricinus communis were identified as homologous unbranched alcohols ranging from C22 to C28 with hydroxyl group at the carbon atoms 1 and 3.
In the leaf cuticular waxes of Myricaria germanica (Tamaricaceae) several alkanediols were identified (Jetter R, Phytochemistry 2000, 55, 169). Hentriacontanediol (C31) with one hydroxyl group in the 12-position and the second one in positions from 2 to 18 is the most abundant diol (9% of the wax). Others were far less abundant : C30-C34 alkanediols with one hydroxyl group on a primary and one on a secondary carbon atom, C25-C43 b-diols and C39-C43 g-diols. Very-long-chain 1,5-alkanediols ranging from C28 to C38, with strong predominance of even carbon numbers, were identified in the cuticular wax of Taxus baccata (Wen M et al., Phytochemistry 2007, 68, 2563). The predominant diol had 32 carbon atoms (29% of the total).
Long-chain saturated C30-C32 diols occur in most marine sediments and in a few instances, such as in Black Sea sediments, they can be the major lipids (de Leeuw JW et al., Geochim Cosmochim Acta 1981, 45, 2281). A microalgal source for these compounds was discovered when Volkman JK et al. (Org Geochem 1992, 18, 131) identified C30-C32 diols in marine eustigmatophytes from the genus Nannochloropsis.
Two nonacosanetriols (7,8,11-nonacosanetriol and 10,12,15-nonacosanetriol) have been isolated from the outer fleshy layer (sarcotesta) of the Ginkgo biloba "fruit" (Zhou G et al., Chem Phys Lipids 2012, 165, 731). They exhibited slight activity of antithrombin and moderate activities of platelet aggregation in vitro.
The chief lipid fraction in the uropygial gland excretion of the domestic hen is a diester wax. The unsaponifiable fraction consists of a series of three homologous compounds, which have been named the uropygiols and identified as 2,3-alkanediols containing 22-24 carbon atoms. These fatty alcohols are esterified by saturated normal C22-C24 fatty acids (Haahti E et al., J Lipid Res 1967, 8, 131).
- Unsaturated alcohols
Some fatty alcohols have one double bond (monounsaturated). Their general formula is:
The unique double bond may be found in different positions: at the C6: i.e. cis-6-octadecen-1-ol (petroselenyl alcohol), C9 i.e cis-9-octadecen-1-ol (oleyl alcohol) and C11 i.e cis-11-octadecen-1-ol (vaccenyl alcohol). Some of these alcohols have insect pheromone activity. As an example, 11-eicosen-1-ol is a major component of the alarm pheromone secreted by the sting apparatus of the worker honeybee. In zooplankton, the cis-11-docosen-1-ol (22:1 (n-11) alcohol) is not only present in high proportion in wax esters (54 to 83%) but may be also predominant in free form (75-94% of free alcohols) in ctenophores (Graeve M et al., Mar Biol 2008, 153, 643). This presence is unexplained because pathways for conversion and catabolism of fatty alcohols in ctenophores are still unknown.
Some short-chain unsaturated alcohols are components of mushroom flavor, such as 1-octen-3-ol, t2-octen-1-ol, and c2-octen-1-ol (Maga JA, J Agric Food Chem 1981, 29, 1).
An acetoxy derivative of a 16-carbon alcohol with one double bond, gyptol (10-acetoxy cis-7-hexadecen-1-ol), was described to be a strong attractive substance secreted by a female moth (Porthetria dispar, "gypsy moth").
A fatty alcohol with two double bonds, bombykol (tr-10,cis-12-hexadecadien-1-ol), was also shown to be excreted as a very strong attractive substance by the female of silk-worm (Bombyx mori).
This first discovery of a pheromone
was made by Butenandt A et al. (Z Naturforsch 1959, 14, 283) who was
formerly Nobel laureate (in 1939) for his work in sex hormones. Another pheromone,
8,10-dodecadienol (codlemone), is secreted by the codling moth Cydia
pomonella, has been used for monitoring and mating in apple and pear
orchards in the USA and Europe. This molecule was also used to monitor the
population of the pea moth Cydia nigricana. Likewise, 7,9-dodecadienol,
the female pheromone of the European grapewine moth Lobesia botrana, was
used to control this important pest in vineyards.
A fatty triol with one double bond, avocadene (16-heptadecene-1,2,4-triol) is found in avocado fruit (Persea americana) and has been tested for anti-bacterial and anti-inflammatory properties. These properties are likely related with the curative effects of avocado described for a number of ailments (diarrhea, dysentery, abdominal pains and high blood pressure). Several others heptadecanols with one primary and two secondary alcohol functions and with one double or triple bond have been identified in the leaves of Persea americana (Lee TH et al., Food Chem 2012, 132, 921). One or two of these alcohol groups may be acetylated. These compounds may be related to the known antifungal activity of Persea leaves.
Long-chain alkenols (C37 to C39) with 2 to 4 double bonds, the reduced form of the alkenones, have been described in the benthic haptophyte Chrysotila lamellosa (Rontani JF et al., Phytochemistry 2004, 65, 117). al., 1986). C30 to C32 alcohols having one or two double bonds are significant constituents of the lipids of marine eustigmatophytes of the genus Nannochloropsis (Volkman JK et al., Org Geochem 1992, 18, 131). These microalgae could be partially the source of the alkenols found in some marine sediments.
Two chlorinated derivatives of unusual alcohols were described in a red alga Gracilaria verrucosa (Shoeb M et al., J Nat Prod 2003, 66, 1509). Both compounds have a C12 aliphatic chain chlorinated in position 2 and with one double bond at carbon 2 (compound 1 : 2-chlorododec-2-en-1-ol) or two double bonds at carbon 2 and 11 (compound 2 : 2-chlorododec-2,11-dien-1-ol).
- Acetylenic alcohols
Natural acetylenic alcohols and their derivatives have been isolated from a wide variety of plant species, fungi and invertebrates. Pharmacological studies have revealed that many of them display chemical and medicinal properties.
Monoacetylenic alcohols : were isolated from culture of Clitocybe catinus (Basidiomycetes) and the study of their structure revealed the presence of two or three hydroxyl groups (Armone A et al., Phytochemistry 2000, 53, 1087). One of these compounds is shown below.
Acetylenic alcohols have been also described in a tropical sponge Reniochaline sp (Lee HS et al., Lipids 2009, 44, 71). One of the two described in that species is shown below, it exhibited a significant growth effect against human tumor cell lines.
Polyacetylenic alcohols : Several examples with different chain lengths, unsaturation degrees, and substitution have been reported from terrestrial plants and marine organisms. Food plants of the Apiaceae (Umbellifereae) plant family such as carrots, celery and parsley, are known to contain several bioactive bisacetylenic alcohols. The main plant sources of these compounds are Angelica dahurica, Heracleum sp and Crithmum maritimum (falcarindiol, falcarinol), red ginseng (Panax ginseng) (panaxacol, panaxydol, panaxytriol), Cicuta virosa (virol A), and Clibadium sylvestre (cunaniol). All these compounds display antibiotic or cytotoxic activities.
Polyacetylenes have been isolated from the stems of Oplopanax elatus (Araliaceae), plant used in Korean and Chinese traditional medicine for anti-inflammatory and analgesic purposes (Yang MC et al., J Nat Prod 2010, 73, 801). Among the most efficient in inhibiting the formation of nitric oxide in LPS-induced cells is a seventeen-carbon diyne diol with an epoxy cycle, oploxyne A. Other parent compounds without the epoxy group were also described.
J. Sci. Food Agric. 2003,
83, 1010). Falcarinl
has potent anticancer properties on primary mammary epithelial cells and was
compared with that of
b-carotene. These results might be important in developing
new cancer treatments with simple and common vegetables. At high concentrations,
falcarinol is capable to induce contact dermatitis.
Falcarinol, a seventeen-carbon diyne fatty alcohol (1,9-heptadecadiene-4,6-diyn-3-ol), was first isolated from Falcaria vulgaris (Bohlmann F et al., Chem Ber 1966, 99, 3552) as well as from Korean ginseng (Takahashi et al., Yakugaku Zasshi 1966, 86, 1053). It was also isolated from carrot (Hansen SL et al.
Falcarinol protects the
vegetable from fungal diseases, it showed biphasic activity, having stimulatory
effects between 0.01 and 0.05 µg per ml and inhibitory effects between 1 and 10
µg per ml, whereas b-carotene
showed no effect in the concentration range 0.001–100 µg per ml (Hansen SL
et al., J Sci Food Agric 2003, 83, 1010). Experiments with
macrophage cells have shown that falcarinol (and its C-8 hydroxylated
derivative, falcarindiol) reduced nitric oxide production, suggesting that these
polyacetylenes are responsible for anti-inflammatory bioactivity (Metzger
BT et al., J Agric Food Chem 2008, 56, 3554). Falcarindiol was first
reported as phytochemicals in carrots (Daucus carota) (Bentley RK et
al., J Chem Soc 1969, 685). Besides falcarinol, falcarindiol, and
falcarindiol 3-acetate, nine additional bisacetylene alcohols were identified in
Daucus carota (Schmiech L et al., J Agric Food Chem 2009, 57, 11030).
Experiments with human intestinal cells demonstrate that aliphatic C17-polyacetylenes (panaxydol, falcarinol, falcarindiol) are potential anticancer principles of carrots and related vegetables (parsley, celery, parsnip, fennel) and that synergistic interaction between bioactive polyacetylenes may be important for their bioactivity (Purup S et al., J Agric Food Chem 2009, 57, 8290). Compounds very similar to falcarinol and extracted from Panax japonicus are potent a-glucosidase inhibitors (Chan HH et al., Phytochemistry 2010, 71, 1360). These inhibitors may potentially reduce the progression of diabetes by decreasing digestion and absorption of carbohydrates.
The water dropwort (Oenanthe crocata), which lives near streams in the Northern Hemisphere, contains a violent toxin, cicutoxin, resulting in convultions and respiratory paralysis (Uwai K et al., J Med Chem 2000, 43, 4508).
The biochemistry and bioactivity of polyacetylenes are presented in a review (Christensen LP et al., J Pharm Biomed Anal 2006, 41, 683) as well methods for the isolation and quantification of these compounds.
Many other polyacetylenic alcohols were found in primitive marine organisms,
such as sponges and ascidians. These invertebrates have no physical defenses and
thus they have developed efficient chemical mechanisms such as polyacetylenic
metabolites to resist predators and bacteria.
A C36 linear diacetylene alcohol named lembehyne was found in an Indonesian marine sponge (Haliclona sp) (Aoki S et al., Tetrahedron 2000, 56, 9945) and was later able to induce neuronal differentiation in neuroblastoma cell (Aoki S et al., Biochem Biophys Res Comm 2001, 289, 558).
Several polyacetylenic alcohols with 22 carbon atoms were isolated and identified in lipid extract from a Red Sea sponge, Callyspongia sp (Youssef DT et al., J Nat Prod 2003, 66, 679). Their physical study revealed the presence of 4 triple bonds and one, two or three double bonds. The structure of one of these Callyspongenols is given below.
Several di- and
tri-acetylenic di-alcohols with a chain of 26 up to 31 carbon atoms, named strongylodiols,
have been isolated from a Petrosia Okinawan marine sponge (Watanabe K
et al., J Nat Prod 2005, 68, 1001). Some of them have cytotoxic
Several polyacetylenic alcohols with 21 carbon atoms were isolated from a marine ascidian (Polyclinidae) and were determined to have two triple bonds combined with a conjugated dienyne group (Gavagnin M et al., Lipids 2004, 39, 681). Some of them have an additional hydroxyl group or only three double bonds. The structure of one of these molecules is given below.
Several brominated polyacetylenic diols with cytotoxic properties were isolated from a Philippines sponge Diplastrella sp (Lerch ML et al., J Nat Prod 2003, 66, 667). One of these molecules is shown below.
A comprehensive survey of acetylenic alcohols in plant and invertebrates with information on their anticancer activity has been released by Dembitsky VM (Lipids 2006, 41, 883).
- Sulfated alcohols
Long-chain di-hydroxy alcohols in which both the primary and secondary hydroxyl groups are converted to sulfate esters and one to five chlorine atoms are introduced at various places have been discovered in the alga Ochromonas danica (Chrysophyceae, Chrysophyta) where they constitute 15% of the total lipids (Haines TH, Biochem J 1969, 113, 565). An example of these chlorosulfolipids is given below. There may be several types of chlorine addition : one at R4, two at R3 and R5 or R1 and R2, five at R1 to R5 and six at R1 to R6.
Similar molecules with a 24 carbon
chain was also described in Ochromonas malhamensis (review in Dembitsky
VM et al., Prog Lipid Res 2002, 41, 315 and in Bedke DK et
al., Nat Prod Rep 2011, 28, 15). It was suggested that the
chlorosulfolipids replace sulfoquinovosyl diglyceride, since when the later is
high the former is low and vice versa. They have been associated with the human
toxicity of the mussel-derived lipids (Diarrhetic Shellfish Poisoning).
Several of these chlorosulfolipids have also been identified from more than 30 species of both freshwater and marine algae belonging to green (Chlorophyceae), brown (Phaeophyceae), red (Rhodophyceae) macrophytic algae (Mercer EI et al., Phytochemistry 1979, 18, 457), and other microalgal species (Mercer EI et al., Phytochemistry 1975, 14, 1545).
Some fatty alcohols, such as dodecanol (lauryl or dodecyl alcohol), are used for the manufacture of detergents after sulphonation (by action of SO3 gas). The salt sodium laurylsulfate (or sodium dodecylsulfate) is a detergent and strong anionic surfactant, used in biochemistry and in the composition of cosmetic products (shampoos, toothpastes).
2 - Branched-chain alcohols
In 1936, Stodola et al. characterized an optically active substance recovered on saponification of ‘‘purified waxes’’ of Mycobacterium tuberculosis, determined its global formula and proposed to name it phthiocerol (Stodola FH et al., J Biol Chem 1936, 114, 467). In 1959, after several chemical studies, its structure was determined as a mixture of C36 and C34b-glycols. It has been proposed that the term phthiocerol be reserved for the original 3-methoxy congener (phthiocerol A) and that the term phthioglycol be used to refer to the family of compounds (Onwueme KC et al., Prog Lipid Res 2005, 44, 259).
Among the most important saturated isopranols found in plants or in geological sediments are those having two (tetrahydrogeraniol), three (farnesanol), or four (phytanol) isoprenoid units. Pristanol (2,6,10,14-tetramethyl-1-pentadecanol) is tetramethylated but with only three complete isoprenoid units.
B - Unsaturated polyisoprenoids (prenols or polyprenols)
They have the following general structure :
These molecules consist of several up to more than 100 isoprene residues linked head-to-tail, with a hydroxy group at one end (a-residue) and a hydrogen atom at the other (w-end).
- 1. all trans forms : They have the following structure:
Some important members of the series are as follows:
Number of isoprene unit
Number of carbons
Long-chain trans-polyprenol (n>8) have been
characterized from Eucommia ulmoides.
Geraniol (from rose oil) is a monoterpene (2 isoprene units). It has a rose-like odor and is commonly used in perfumes and as several fruit flavors. Geraniol is also an effective mosquito repellent. Inversely, it can attract bees as it is produced by the scent glands of honey bees to help them mark nectar-bearing flowers and locate the entrances to their hives.
Farnesol is a sesquiterpene (3 isoprene units). It is the prenol that corresponds to the carbon skeleton of the simplest juvenile hormone described for the first time in insects in 1961 (Schmialek PZ, Z Naturforsch 1961, 16b, 461; Wigglesworth VB, J Insect Physiol 1961, 7, 73). It is present in many essential oils such as citronella, neroli, cyclamen, lemon grass, rose, and others. It is used in perfumery to emphasize the odors of sweet floral perfumes. It is especially used in lilac perfumes. As a pheromone, farnesol is a natural pesticide for mites. The dimorphic fungus Candida albicans has been shown to use farnesol as quorum-sensing molecule (Hornby JM et al., Appl Environ Microbiol 2001, 67, 2982).
Geranylgeraniol is a diterpene (4 isoprene units). Geraniol and geranylgeraniol are important molecules in the synthesis of various terpenes, the acylation of proteins and the synthesis of vitamins (Vitamins E and K). The covalent addition of phosphorylated derivatives of typical isoprenoids, farnesyl pyrophosphate and geranylgeranyl pyrophosphate, to proteins is a process (prenylation) common to G protein subunits. These isoprenylated proteins have key roles in membrane attachment leading to central functionality in cell biology and pathology.
Solanesol, discovered in tobacco leaves in 1956 (Rowland RL et al., J Am Chem Soc 1956, 78, 4680), may be an important precursor of the tumorigenic polynuclear aromatic hydrocarbons of smoke but is also a possible side chain for plastoquinone. Solanesol is also present in the leaves of other Solanaceae plants including tomato, potato, eggplant and pepper. It has useful medicinal properties and is known to possess anti-bacterial, anti-inflammation, and anti-ulcer activities (Khidyrova NK et al., Chem Nat Compd 2002, 38, 107). Industrially, solanesol is extracted from Solanaceae leaves (about 450 tons in 2008) and used as an intermediate in the synthesis of coenzyme Q10 and vitamin K analogues.
Spadicol was discovered in the spadix (inflorescence) of the Araceae Arum maculatum (Hemming FW et al., Proc R Soc London 1963, 158, 291). Its presence is likely related to its presence in the ubiquinone as the side-chain.
Phytol is a partially saturated diterpene, a monounsaturated derivative of geranylgeraniol which is part of the chlorophyll molecule :
- 2. ditrans-polycis-prenols, such as the bacteria prenol and betulaprenol types. In general, bacteria, as all prokaryotic cells, possess ditrans-polycis-prenols containing between 10 and 12 units, the most abundant being undecaprenol (trivial name bactoprenol).
Betulaprenols with n = 3-6 were
isolated from the woody tissue of Betula verrucosa (Wellburn AR et
al., Nature 1966, 212, 1364), and bacterial polyprenol with n = 8 were
isolated from Lactobacillus plantarum (Gough DP et al., Biochem J
1970, 118, 167). Betulaprenol-like species with 14 to 22 isoprene units have
been discovered in leaves of Ginkgo biloba (Ibata K et al., Biochem J
1983, 213, 305).
Polyisoprenoid alcohols are accumulated in the cells most often as free alcohols and/or esters with carboxylic acids. A fraction of polyisoprenoid phosphates has also been detected, and this form is sometimes predominant in dividing cells and Saccharomyces cerevisiae (Adair WL et al., Arch Biochem Biophys 1987, 259, 589).
- 3. tritrans-polycis-prenols, of the ficaprenol type.Some of the earliest samples were obtained from Ficus elastica, giving rise to the trivial names ficaprenol-11 and ficaprenol-12 (Stone KJ et al. Biochem J 1967, 102, 325).
In plants, the diversity of polyprenols is much broader, their chain length covers the broad spectrum of compounds ranging from 6 up to 130 carbon atoms (Rezanka T et al., J Chromatogr A 2001, 936, 95).
- 4. dolichol types, the a
terminal is saturated.
Most eukaryotic cells contain one type of polyisoprenoid alcohols with one a-saturated isoprenoid unit (2,3-dihydro polycis-prenols) which have been called dolichol by Pennock JF et al. (Nature 1960, 186, 470), a derivative of prenols. Most of these carry two trans units at the w-end of the chain.
Dolichols (fro the Greek dolikos: long) have the general structure :
Dolichols isolated from yeast or
animal cells consist mainly of seven to eight compounds, those with 16, 18, or
19 isoprenoid units being the most abundant (Ragg SS, Biochem Biophys Res
Comm 1998, 243, 1).
Dolichol amount was shown to be increased in the brain gray matter of elderly (Pullarkat RK
et al., J Biol Chem 1982, 257, 5991). Dolichols with 19, 22 and 23
isoprenoid units were described as early as 1972 in marine invertebrates (Walton
MJ et al., Biochem J 1972, 127, 471). Furthermore, the pattern of their distribution may be
considered as a chemotaxonomic criterion. It has been reported that a high
proportion of dolichols is esterified to fatty acids. As an example, 85-90% of
dolichols are esterified in mouse testis (Potter
J et al., Biochem Biophys Res Comm 1983, 110, 512). In addition, dolichyl
dolichoate has been found in bovine thyroid (Steen
L. et al., Biochim Biophys Acta, 1984, 796, 294).
They are well known for their important role as glycosyl carrier in a phosphorylated form in the synthesis of polysaccharides and glycoproteins in yeast cells, and animals. Dolichyl phosphate is an obligatory intermediate in the biosynthesis of N-glycosidically linked oligosaccharide chains. Conversely, they have been identified as the predominant isoprenoid form in roots (Skorupinska-Tudek K et al., Lipids 2003, 38, 981) and in mushroom tissue (Wojtas M et al., Chem Phys Lipids 2004, 130, 109). Similar compounds (ficaprenols) have the same metabolic function in plants.
The repartition of the various types of polyisoprenoid alcohols between plants and animals and their metabolism have been extensively discussed (Swiezewska E et al., Prog Lipid Res 2005, 44, 235). Biosynthesis of polyisoprenoid alcohols and their biological role have been reviewed in 2005 (Swiezewska E et al., Prog Lipid Res 2005, 44, 235).
3 - Phenolic alcohols
Among the simple phenolic alcohols, monolignols are the source materials for biosynthesis of both lignans and lignin. The starting material for production of monolignols (phenylpropanoid) is the amino acid phenylalanine. There are two main monolignols: coniferyl alcohol and sinapyl alcohol. Para-coumaryl alcohol is similar to conipheryl alcohol but without the methoxy group.
Conipheryl alcohol is found in both gymnosperm and angiosperm
plants. Sinapyl alcohol and para-coumaryl alcohol, the other two lignin
monomers, are found in angiosperm plants and grasses. Conipheryl esters (conypheryl
8-methylnonanoate) have been described in the fruits of the pepper, Capsicum
baccatum (Kobata K et al., Phytochemistry 2008, 69, 1179). These
compounds displayed an agonist activity for transient receptor potential
vanilloid 1 (capsaicin receptor) as the well known capsaicinoids present in
these plant species.
Complex phenolic alcohols (phenolphthiocerol) were shown to be components of Mycobacterium glycolipids which are termed glycosides of phenolphthiocerol dimycocerosate (Smith DW et al., Nature 1960, 186, 887) belonging to the large family of "mycosides". The chain length differs according to the homologues, 18 and 20 carbon atoms in mycosides A, and B, respectively. One of these phenolphthiocerols is shown below.
An analogue component but with a ketone group instead of the methoxy group, a phenolphthiodiolone, has been detected in mycoside A (Fournie JJ et al., J Biol Chem 1987, 262, 3174).
An alcohol with a furan group, identified as 3-(4-methylfuran-3-yl)propan-1-ol, has been isolated from a fungal endophyte living in a plant, Setaria viridis (Nakajima H et al., J Agric Food Chem 2010, 58, 2882). That compound was found to have a repellent effect on an insect, Eysarcoris viridis, which is a major pest of rice.
Some cyclic alkyl polyols have been reported in plants. Among the various form present in an Anacardiaceae, Tapirira guianensis, from South America, two displayed anti-protozoal (Plasmodium falciparum) and anti-bacterial (Staphylococcus spp) activities (Roumy V et al., Phytochemistry 2009, 70, 305). The structure shown below is that of a trihydroxy-alcohol containing a cyclohexene ring.
As emphasized by the
authors, external application of the active plant extract or of the
purified compounds could represent an accessible therapeutic alternative to
classical medicine against leishmaniasis.
aldehydes are found in free form, but also in the form of vinyl ether (known as alk-1-enyl
ether) integated in glycerides and phospholipids (plasmalogens).
The free aldehydes can be as fatty acids saturated or unsaturated. They have a general formula CH3(CH2)nCHO with n=6 to 20 or greater. The most common is palmitaldehyde (hexadecanal) with a 16 carbon chain. Normal monoenoic aldehydes are analogous to the monoenoic fatty acids.
It must be noticed that an aldehyde function may be found at a terminal (w) position while an acid function is present at the other end of the carbon chain (oxo fatty acids). These compounds have important signaling properties in plants.
Long-chain aldehydes have been described in the waxes which impregnate the matrix covering all organs of plants (Vermeer CP et al., Phytochemistry 2003, 62, 433). These compounds forming about 7% of the leaf cuticular waxes of Ricinus communis were identified as homologous unbranched aldehydes ranging from C22 to C28 with a hydroxyl group at the carbon 3. Long-chain 5-hydroxyaldehydes with chain lengths from C24 to C36, the C28 chain being the most abundant, were identified in the cuticular wax of Taxus baccata needles (Wen M et al., Phytochemistry 2007, 68, 2563). Long-chain aliphatic aldehydes with chain-length from C22 to C30 are also present in virgin olive oils, hexacosanal (C26) being the most abundant aldehyde (Perez-Camino MC et al., Food Chem 2012, 132, 1451).
Aldehydes may be produced during decomposition of fatty acid hydroperoxides following a peroxidation attack. Several aldehydes (hexanal, heptanal..) belong to aroma compounds which are found in environmental or food systems (see the website: Flavornet). Aldehydes (mono- or di-unsaturated) with 5 to 9 carbon atoms are produced by mosses (Bryophyta) after mechanical wounding (Croisier E et al., Phytochemistry 2010, 71, 574). It was shown that they were produced by oxidative fragmentation of polyunsaturated fatty acids (C18, C20). Trans-2-nonenal is an unsaturated aldehyde with an unpleasant odor generated during the peroxidation of polyunsaturated fatty acids. It participates to body odor and is found mainly covalently bound to protein in vivo (Ishino K et al., J Biol Chem 2010, 285, 15302).
Fatty aldehydes may be determined easily by TLC or gas liquid chromatography (follow that link). The most common method for the determination of aldehydes involves derivatization with an acidic solution of 2,4-dinitrophenylhydrazine to form corresponding hydrazones followed by HPLC separation and UV–VIS detection. An optimized derivatization procedure for the determination of aliphatic C1-C10 aldehydes has been described (Stafiej A et al., J Biochem Biophys Meth 2006, 69, 15).
Other short-chain aldehydes (octadienal, octatrienal, heptadienal) are produced via a lipoxygenase-mediated pathway from polyunsaturated fatty acids esterifying glycolipids in marine diatoms (D'Ippolito G et al., Biochim Biophys Acta 2004, 1686, 100). Heighteen species of diatoms have been shown to release unsaturated aldehydes (C7:2, C8:2, C8:3, C10:2, and C10:3) upon cell disruption (Wichard T et al., J Chem Ecol 2005, 31, 949).
Several short-chain aldehydes were shown to induce deleterious effects on zooplankton crustaceans and thus limiting the water secondary production (birth-control aldehydes) (D'Ippolito G et al., Tetrahedron Lett 2002, 43, 6133). In laboratory experiments, three decatrienal isomers produced by various diatoms were shown to arrest embryonic development in copepod and sea urchins and have antiproliferative and apoptotic effects on carcinoma cells (Miralto A et al., Nature 1999, 402, 173). Later, the copepod recruitment in blooms of planktonic diatom was shown to be suppressed by ingestion of dinoflagellate aldehydes (Nature 2004, 429, 403). It was demonstrated that diatoms can accurately sense a potent 2E,4E/Z-decadienal and employ it as a signaling molecule to control diatom population sizes (Vardi A et al., PLoS Biol 2006, 4, e60). This aldehyde triggered a dose-dependent calcium transient that has derived from intracellular store. Subsequently, calcium increase led to nitric oxide (NO) generation by a calcium-dependent NO synthase-like activity, resulting in cell death in diatoms.
Myeloperoxidase-derived chlorinated aldehydes with plasmalogens has been reported. Thus, the vinyl-ether bond of plasmalogens is susceptible to attack by HOCl to yield a lysophospholipid and an
Both these chloro-fatty aldehydes have been detected in neutrophils activated
with PMA (Thukkani
AK et al., J Biol Chem 2002, 277, 3842) and in human atherosclerotic
AK et al., Circulation 2003, 108, 3128). Furthermore,
2-chlorohexadecanal was shown to induce COX-2 expression in human coronary
artery endothelial cells (Messner
MC et al., Lipids 2008, 43, 581). These data suggest that
2-chlorohexadecanal and possibly its metabolite 2-chlorohexadecanoic acid, both produced during leukocyte activation, may alter vascular endothelial cell
function by upregulation of COX-2 expression.
Long after the demonstration of the presence of iodinated lipids in thyroid (besides iodinated aminoacids), it was shown that the major iodinated lipid formed in thyroid when incubated in vitro with iodide was 2-iodohexadecanal (Pereira A et al, J Biol Chem 1990, 265, 17018). In rat and dog thyroid, 2-iodooctadecanal was determined to be more abundant that the 16-carbon aldehyde. These compounds, which are thought to play a role in the regulation of thyroid function, were recently shown to be formed by the attack of reactive iodine on the vinyl ether group of PE plasmalogen. This attack generates an unstable iodinated derivative which breaks into lysophosphatidylethanolamine and 2-iodo aldehydes (Panneels V et al, J Biol Chem 1996, 271, 23006).
In some bacteria, aldehyde analogs of cyclopropane fatty acids were described.
Several fatty aldehydes are known to have pheromone functions. Studies in African and Asian countries have shown that the use of 10,12-hexadecadienal could be effective for control of the spiny bollworm Earias insulana, a cotton pest. The sex pheromone of the navel orange worm, Amyelois transitella, 11,13-hexadecadienal, is usually used in the control of this citric pest.
A branched saturated aldehyde (3,5,9-trimethyldodecenal, stylopsal) has been identified as a female-produced sex pheromone in Stylops (Strepsiptera), an entomophagous endoparasitic insect (Cvacka J et al., J Chem Ecol 2012, 38, 1483).
Several isoprenoid aldehydes are important in insect biology as pheromones and in botany as volatile odorous substances. Some examples are given below:
These three terpenic aldehydes are produced in large amounts by
the mandibular glands of ants and may function as defensive repellents (Regnier
FE et al., J Insect Physiol 1968, 14, 955). In contrast, the same molecules
have a role of recruiting pheromones in honeybees
Citral, a mixture of the tautomers geranial (trans-citral) and neral (cis-citral) is a major component (more than 60%) of the lemongrass (Cymbopogon flexuosus) oil. Lemongrass is widely used, particularly in Southeast Asia and Brazil, as a food flavoring, as a perfume, and for its medicinal properties (analgesic and anti-inflammatory). It was found that citral is a major suppressor of COX-2 expression and an activator of PPARa and g (Katsukawa M et al., Biochim Biophys Acta 2010, 1801, 1214).
It was demonstrated that damaged leaves released 2-hexenal, among other C6-volatile aldehydes, produced from the catalytic activity of hydroperoxide lyase (Turlings TC et al., Proc Ntl Acad Sci USA 1995, 92, 4169). These compounds, considered as signal molecules, can trigger several responses in neighboring plants and may also act as antimicrobial agents (Farmer EE, Nature 2001, 411, 854).
One important constituent of this group of aldehydes is retinal, one active form of vitamin A involved in the light reception of animal eyes but also in bacteria as a component of the proton pump.
Retinal exist in two forms, a cis and a trans isomer. On illumination with
white light, the visual pigment, rhodopsin is converted to a mixture of a protein (opsin)
and trans-retinal. This isomer must be transformed into the cis form by retinal isomerase
before it combines again with opsin (dark phase). Both isomers can be reduced to retinol (vitamin A) by a NADH dependent alcohol dehydrogenase.
Retinol is stocked in retina mainly in an acylated form.
Cinnamic aldehyde (cinnamaldehyde) is the key flavor compound in cinnamon essential oil extracted from Cinnamomum zeylanicum and Cinnamomum cassia bark. Investigations have revealed than that benzyl aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells (Wondrak GT et al., Molecules 2010, 15, 3338). Cinnamic aldehyde may therefore represent a precious chemopreventive dietary factor targeting colorectal carcinogenesis.


How to Check Your Dog’s Pulse
6 of 7 in Series: The Essentials of Dog Care for a Healthy Pet
To check your dog’s pulse, you need to locate the femoral artery, which lies just below the skin on the inside of the back legs, between two large muscles where the leg joins the body.
With your dog standing, reach around in front of the rear leg where it joins his body, and slide your fingers into the groin area. You can feel the femoral artery pumping each time the heart beats.
When you have found the artery with your dog standing, try it with your dog lying on his side. Count how many pulses you feel in 15 seconds and multiply by 4 to get the number of beats per minute. Dogs normally have a pulse between 70 and 120 beats per minute. In puppies, the pulse ranges from 120 to 160 beats per minute.
Become familiar with your dog’s pulse rate and how his pulse feels when he is relaxed as well as after exercise.
If you have reason to believe your dog is suffering from an emergency, a dramatic change in pulse (such as, a slowed pulse indicating shock) can be one sign and symptom.


Rainy Day Painting
Create your very own creepy, haunted castle sitting in a turbulent field of flowing grass, eerily surrounded by dark, ominous clouds.
Fireworks are such an exciting part of part of summer festivities, but it's sad when the show is over. Keep them alive all year long with watercolor fireworks.
Show your high schooler how to celebrate Mary Cassatt, an Impressionist painter, by creating a mother-child painting in her style.
Put your individual fingerprint on the 100th Day of School (literally!) with this activity.
Show your preschooler how to make a print of a butterfly using her hand as a tool--a great way to stimulate her sense of touch.
Use marbles and paint to explore the wild world of shapes and color...and build kindergarten writing strength, too.
Introduce your kindergartener to some art history by showing him how to create an everyday object print, Andy Warhol-style.
Celebrate the changing seasons with this fun, hands-on art activity that will teach your child about the different colors of the seasons.
Help your preschooler begin reading and writing the printed word by connecting simple letter recognition exercises with this easy art project: alphabet trees!


the energy [r]evolution
The climate change imperative demands nothing short of an Energy [R]evolution. The expert consensus is that this fundamental shift must begin immediately and be well underway within the next ten years in order to avert the worst impacts. What is needed is a complete transformation of the way we produce, consume and distribute energy, while at the same time maintaining economic growth. Nothing short of such a revolution will enable us to limit global warming to less than a rise in temperature of 2° Celsius, above which the impacts become devastating.
Current electricity generation relies mainly on burning fossil fuels, with their associated CO2 emissions, in very large power stations which waste much of their primary input energy. More energy is lost as the power is moved around the electricity grid network and converted from high transmission voltage down to a supply suitable for domestic or commercial consumers. The system is innately vulnerable to disruption: localised technical, weather-related or even deliberately caused faults can quickly cascade, resulting in widespread blackouts. Whichever technology is used to generate electricity within this old fashioned configuration, it will inevitably be subject to some, or all, of these problems. At the core of the Energy [R]evolution there therefore needs to be a change in the way that energy is both produced and distributed.
4.1 key principles
the energy [r]evolution can be achieved by adhering to five key principles:
1.respect natural limits – phase out fossil fuels by the end of this century We must learn to respect natural limits. There is only so much carbon that the atmosphere can absorb. Each year humans emit over 25 billion tonnes of carbon equivalent; we are literally filling up the sky. Geological resources of coal could provide several hundred years of fuel, but we cannot burn them and keep within safe limits. Oil and coal development must be ended. The global Energy [R]evolution scenario has a target to reduce energy related CO2 emissions to a maximum of 10 Gigatonnes (Gt) by 2050 and phase out fossil fuels by 2085.
2.equity and fairness As long as there are natural limits there needs to be a fair distribution of benefits and costs within societies, between nations and between present and future generations. At one extreme, a third of the world’s population has no access to electricity, whilst the most industrialised countries consume much more than their fair share.
The effects of climate change on the poorest communities are exacerbated by massive global energy inequality. If we are to address climate change, one of the core principles must be equity and fairness, so that the benefits of energy services – such as light, heat, power and transport – are available for all: north and south, rich and poor. Only in this way can we create true energy security, as well as the conditions for genuine human wellbeing.
The Advanced Energy [R]evolution scenario has a target to achieve energy equity as soon as technically possible. By 2050 the average per capita emission should be between 1 and 2 tonnes of CO2.
3.implement clean, renewable solutions and decentralise energy systems. There is no energy shortage. All we need to do is use existing technologies to harness energy effectively and efficiently. Renewable energy and energy efficiency measures are ready, viable and increasingly competitive. Wind, solar and other renewable energy technologies have experienced double digit market growth for the past decade.
Just as climate change is real, so is the renewable energy sector. Sustainable decentralised energy systems produce less carbon emissions, are cheaper and involve less dependence on imported fuel. They create more jobs and empower local communities. Decentralised systems are more secure and more efficient. This is what the Energy [R]evolution must aim to create.
To stop the earth’s climate spinning out of control, most of the world’s fossil fuel reserves – coal, oil and gas – must remain in the ground. Our goal is for humans to live within the natural limits of our small planet.
4.decouple growth from fossil fuel use Starting in the developed countries, economic growth must be fully decoupled from fossil fuel usage. It is a fallacy to suggest that economic growth must be predicated on their increased combustion.
We need to use the energy we produce much more efficiently, and we need to make the transition to renewable energy and away from fossil fuels quickly in order to enable clean and sustainable growth.
5.phase out dirty, unsustainable energyWe need to phase out coal and nuclear power. We cannot continue to build coal plants at a time when emissions pose a real and present danger to both ecosystems and people. And we cannot continue to fuel the myriad nuclear threats by pretending nuclear power can in any way help to combat climate change. There is no role for nuclear power in the Energy [R]evolution.