 This is consistent with the difficulty of overdose reversal seen with high-affinity opioids in the fentanyl chemical family or with buprenorphine.
<clarity>  This is consistent with the difficulty of overdose reversal seen with high-affinity opioids in the fentanyl chemical family or with buprenorphine.
 This difficulty is regularly encountered when treating overdoses of high-affinity opioids in the fentanyl chemical family or with buprenorphine.