 Furthermore, TARGIT inhibits the stimulating effects of wound fluid on cancer cells, suggesting for the first time, a beneficial effect of intraoperative radiotherapy (IORT) on tumour microenvironment. In these studies, women treated with  TARGIT-IORT  during lumpectomy for breast cancer combined with whole breast radiotherapy had a significantly low mortality from non-breast-cancer causes, such as cardiovascular and lung complications, as well as other cancers compared with those who received whole breast radiotherapy.
<clarity>  Furthermore, TARGIT inhibits the stimulating effects of wound fluid on cancer cells, suggesting for the first time, a beneficial effect of intraoperative radiotherapy (IORT) on tumour microenvironment. In these studies, women treated with  TARGIT-IORT  during lumpectomy for breast cancer combined with whole breast radiotherapy had a significantly low mortality from non-breast-cancer causes, such as cardiovascular and lung complications, as well as other cancers compared with those who received whole breast radiotherapy.
 The use in TARGIT of a small treatment device which can be positioned in close physical proximity to the treatment site aims to avoid some of these practical issues. TARGIT irradiation has also been shown to affect the properties of wound fluid, which may be linked to cancer cell proliferation and possibly local recurrence. TARGIT-IORT during lumpectomy for breast cancer combined with whole breast radiotherapy had a significantly low mortality from non-breast-cancer causes, such as cardiovascular and lung complications, as well as other cancers compared with those who received whole breast radiotherapy.