 Lactate is the end product of glycolysis and increased circulating levels of lactate are associated with increased muscle glycogen breakdown with exercise. Circulating lactate levels have been found higher in heat-sensitive patients with variants in genes encoding the skeletal muscle calcium release channel, as compared to asymptomatic carriers of the same variants.
<coherence>  Lactate is the end product of glycolysis and increased circulating levels of lactate are associated with increased muscle glycogen breakdown with exercise. Circulating lactate levels have been found higher in heat-sensitive patients with variants in genes encoding the skeletal muscle calcium release channel, as compared to asymptomatic carriers of the same variants.