 But hopes that the first trial collisions would be carried out before the machine's official inauguration on October 21, 2008 now looks doubtful.
<meaning-changed>  But hopes that the first trial collisions would be carried out before the machine's official inauguration on October 21, 2008 now looks doubtful.
 The recent setbacks, however, mean that hopes the first trial collisions would be carried out before the machine's official inauguration on October 21, 2008 now looks doubtful.