<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is familial-hypercholesterolemia and explain in detail? [/INST] If your symtopms are extreme please call 911. Adults and children who have familial hypercholesterolemia have very high levels of low-density lipoprotein (LDL) cholesterol in their blood. LDL cholesterol is known as "bad" cholesterol because it can build up in the walls of the arteries, making them hard and narrow. LDL This excess cholesterol is sometimes deposited in certain portions of the skin, some tendons and around the iris of the eyes:
Skin. The most common spots for cholesterol deposits to occur is on the hands, elbows and knees. They also can occur in the skin around the eyes.
Tendons. Cholesterol deposits may thicken the Achilles tendon, along with some tendons in the hands.
Eyes. High cholesterol levels can cause corneal arcus, a white or gray ring around the iris of the eye. This happens most commonly in older people, but it can occur in younger people who have familial hypercholesterolemia.
 Causes Familial hypercholesterolemia is caused by a gene alteration that's passed down from one or both parents. People who have this condition are born with it. This change prevents the body from ridding itself of the type of cholesterol that can build up in the arteries and cause heart disease. Risk factors The risk of familial hypercholesterolemia is higher if one or both of your parents have the gene alteration that causes it. Most people who have the condition receive one affected gene. But in rare cases, a child can get the affected gene from both parents. This can cause a more severe form of the condition. Familial hypercholesterolemia may be more common in certain populations, including:
Ashkenazi Jews
Some Lebanese groups
French Canadians
 Complications People who have familial hypercholesterolemia have a higher risk of heart disease and death at a younger age. Heart attacks may occur before age 50 in men and age 60 in women. The rarer and more severe variety of the condition, if undiagnosed or untreated, can cause death before age 20.

 By Mayo Clinic Staff By Mayo Clinic Staff Request an appointment Request an appointment   Diagnosis & treatment Diagnosis & treatment Diagnosis & treatment
    Sept. 23, 2021
 Print Print  Share on: FacebookTwitter Facebook Twitter Show references
Kliegman RM, et al. Defects in metabolism of lipids. In: Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021.
Goldman L, et al., eds. Disorders of lipid metabolism. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021.
Familial hypercholesterolemia. Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/fh/FH.htm. Accessed July 15, 2021.
Inheriting issues with cholesterol. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/causes-of-high-cholesterol/familial-hypercholesterolemia-fh. Accessed July 15, 2021.
AskMayoExpert. Familial hypercholesterolemia. Mayo Clinic; 2020.
Rosenson RS, et al. Familial hypercholesterolemia in adults: Overview. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
De Ferranti SD. Familial hypercholesterolemia in children. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
Blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol. Accessed July 15, 2021.
Rosenson RS, et al. Familial hypercholesterolemia in adults: Treatment. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
 Show references
Kliegman RM, et al. Defects in metabolism of lipids. In: Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021.
Goldman L, et al., eds. Disorders of lipid metabolism. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021.
Familial hypercholesterolemia. Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/fh/FH.htm. Accessed July 15, 2021.
Inheriting issues with cholesterol. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/causes-of-high-cholesterol/familial-hypercholesterolemia-fh. Accessed July 15, 2021.
AskMayoExpert. Familial hypercholesterolemia. Mayo Clinic; 2020.
Rosenson RS, et al. Familial hypercholesterolemia in adults: Overview. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
De Ferranti SD. Familial hypercholesterolemia in children. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
Blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol. Accessed July 15, 2021.
Rosenson RS, et al. Familial hypercholesterolemia in adults: Treatment. https://www.uptodate.com/contents/search. Accessed July 15, 2021.

Kliegman RM, et al. Defects in metabolism of lipids. In: Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021.
Goldman L, et al., eds. Disorders of lipid metabolism. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021.
Familial hypercholesterolemia. Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/fh/FH.htm. Accessed July 15, 2021.
Inheriting issues with cholesterol. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/causes-of-high-cholesterol/familial-hypercholesterolemia-fh. Accessed July 15, 2021.
AskMayoExpert. Familial hypercholesterolemia. Mayo Clinic; 2020.
Rosenson RS, et al. Familial hypercholesterolemia in adults: Overview. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
De Ferranti SD. Familial hypercholesterolemia in children. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
Blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol. Accessed July 15, 2021.
Rosenson RS, et al. Familial hypercholesterolemia in adults: Treatment. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
 Kliegman RM, et al. Defects in metabolism of lipids. In: Nelson Textbook of Pediatrics. 21st ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Goldman L, et al., eds. Disorders of lipid metabolism. In: Goldman-Cecil Medicine. 26th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed July 15, 2021. Familial hypercholesterolemia. Centers for Disease Control and Prevention. https://www.cdc.gov/genomics/disease/fh/FH.htm. Accessed July 15, 2021. Inheriting issues with cholesterol. American Heart Association. https://www.heart.org/en/health-topics/cholesterol/causes-of-high-cholesterol/familial-hypercholesterolemia-fh. Accessed July 15, 2021. AskMayoExpert. Familial hypercholesterolemia. Mayo Clinic; 2020. Rosenson RS, et al. Familial hypercholesterolemia in adults: Overview. https://www.uptodate.com/contents/search. Accessed July 15, 2021. De Ferranti SD. Familial hypercholesterolemia in children. https://www.uptodate.com/contents/search. Accessed July 15, 2021. Blood cholesterol. National Heart, Lung, and Blood Institute. https://www.nhlbi.nih.gov/health-topics/blood-cholesterol. Accessed July 15, 2021. Rosenson RS, et al. Familial hypercholesterolemia in adults: Treatment. https://www.uptodate.com/contents/search. Accessed July 15, 2021.
Familial hypercholesterolemiaSymptoms & causesDiagnosis & treatmentDoctors & departments
 Familial hypercholesterolemia Symptoms & causesDiagnosis & treatmentDoctors & departments </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is graves-disease and explain in detail? [/INST] If your symtopms are extreme please call 911.

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Enlarged thyroid
Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right).

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Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right).

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Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right).

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Enlarged thyroid

Enlarged thyroid
Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right).

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Enlarged thyroid
Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right).
 Enlarged thyroid Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Widespread enlargement of the thyroid can expand the gland well beyond its typical size (left) and cause a noticeable bulge in the neck (right). Common signs and symptoms of Graves' disease include:
Anxiety and irritability
A fine tremor of the hands or fingers
Heat sensitivity and an increase in perspiration or warm, moist skin
Weight loss, despite normal eating habits
Enlargement of the thyroid gland (goiter)
Change in menstrual cycles
Erectile dysfunction or reduced libido
Frequent bowel movements
Bulging eyes (Graves' ophthalmopathy)
Fatigue
Thick, red skin usually on the shins or tops of the feet (Graves' dermopathy)
Rapid or irregular heartbeat (palpitations)
Sleep disturbance
 Graves' ophthalmopathy

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Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids.

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Graves' ophthalmopathy
Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids.

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Graves' ophthalmopathy

Graves' ophthalmopathy
Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids.

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Graves' ophthalmopathy

Graves' ophthalmopathy
Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids.

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Graves' ophthalmopathy
Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids.
 Graves' ophthalmopathy Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. Graves' ophthalmopathy signs and symptoms include bulging eyes, redness and retracting eyelids. About 30% of people with Graves' disease show some signs and symptoms of Graves' ophthalmopathy. In Graves' ophthalmopathy, inflammation and other immune system events affect muscles and other tissues around your eyes. Signs and symptoms may include:
Bulging eyes
Gritty sensation in the eyes
Pressure or pain in the eyes
Puffy or retracted eyelids
Reddened or inflamed eyes
Light sensitivity
Double vision
Vision loss
 Graves' dermopathy

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Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet.

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Graves' dermopathy
Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet.

Close

Graves' dermopathy

Graves' dermopathy
Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet.

Close

Graves' dermopathy

Graves' dermopathy
Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet.

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 Close Graves' dermopathy
Graves' dermopathy
Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet.
 Graves' dermopathy Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. Rarely, people who have Graves' disease develop a reddish thickening of the skin that resembles the texture of an orange peel (Graves' dermopathy). This results from a buildup of protein in the skin. It often occurs on the shins and on the tops of the feet. An uncommon manifestation of Graves' disease, called Graves' dermopathy, is the reddening and thickening of the skin, most often on your shins or the tops of your feet. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is idiopathic-thrombocytopenic-purpura and explain in detail? [/INST] If your symtopms are extreme please call 911.

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Petechiae
Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B).

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Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B).

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Petechiae
Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B).

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Petechiae

Petechiae
Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B).

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Petechiae
Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B).
 Petechiae Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Petechiae may look like a rash and usually appear in clusters. Here they appear on a leg (A) and on an abdomen (B). Immune thrombocytopenia may have no signs and symptoms. When they do occur, they may include:
Easy or excessive bruising
Superficial bleeding into the skin that appears as pinpoint-sized reddish-purple spots (petechiae) that look like a rash, usually on the lower legs
Bleeding from the gums or nose
Blood in urine or stools
Unusually heavy menstrual flow
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is ischemic-colitis and explain in detail? [/INST] If your symtopms are extreme please call 911. Symptoms of ischemic colitis can include:
Pain, tenderness or cramping in your belly, which can occur suddenly or happen over time
Bright red or maroon blood in your stool or, at times, passage of blood alone without stool
A feeling of urgency to move your bowels
Diarrhea
Nausea
 The risk of severe complications is higher when you have symptoms on the right side of your belly. This is less commonly seen compared with left-sided colitis. People with right-sided colitis tend to have more underlying medical problems, such as high blood pressure, atrial fibrillation and kidney disease. They more frequently have to undergo surgery and also have a higher risk of death. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is broken-wrist and explain in detail? [/INST] If your symtopms are extreme please call 911. A broken wrist might cause these signs and symptoms:
Severe pain that might worsen when gripping or squeezing or moving your hand or wrist
Swelling
Tenderness
Bruising
Obvious deformity, such as a bent wrist
 When to call a doctor If you think you might have a broken wrist, see a doctor immediately, especially if you have numbness, swelling or trouble moving your fingers. A delay in diagnosis and treatment can lead to poor healing, decreased range of motion and decreased grip strength. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is type-2-diabetes-in-children and explain in detail? [/INST] If your symtopms are extreme please call 911. Type 2 diabetes in children may develop so gradually that there are no noticeable symptoms. Sometimes, the disorder is diagnosed during a routine check-up. Some children might experience these signs and symptoms as a result of too much sugar in their bloodstreams:
Increased thirst
Frequent urination
Increased hunger
Fatigue
Blurry vision
Darkened areas of skin, most often around the neck or in the armpits and groin
Unintended weight loss, although this is less common in children with type 2 diabetes than in children with type 1 diabetes
Frequent infections
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is prehypertension and explain in detail? [/INST] If your symtopms are extreme please call 911. Elevated blood pressure doesn't cause symptoms. The only way to detect it is to have regular blood pressure checks. Have your blood pressure measured when you visit your health care provider. You can also check it at home with a home blood pressure monitoring device. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is heart-murmurs and explain in detail? [/INST] If your symtopms are extreme please call 911. Harmless (innocent) heart murmurs usually don't cause any other symptoms. Symptoms of worrisome heart murmurs depend on the cause. Heart murmur symptoms may include:
Blue or gray fingernails or lips
Chest pain
Cough that doesn't go away
Dizziness
Swollen liver
Swollen neck veins
Fainting
Heavy sweating with little or no activity
In infants, poor appetite and lack of growth
Shortness of breath
Swelling or sudden weight gain
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is menopause and explain in detail? [/INST] If your symtopms are extreme please call 911. In the months or years leading up to menopause (perimenopause), you might experience these signs and symptoms:
Irregular periods
Vaginal dryness
Hot flashes
Chills
Night sweats
Sleep problems
Mood changes
Weight gain and slowed metabolism
Thinning hair and dry skin
Loss of breast fullness
 Signs and symptoms, including changes in menstruation can vary among women. Most likely, you'll experience some irregularity in your periods before they end. Skipping periods during perimenopause is common and expected. Often, menstrual periods will skip a month and return, or skip several months and then start monthly cycles again for a few months. Periods also tend to happen on shorter cycles, so they are closer together. Despite irregular periods, pregnancy is possible. If you've skipped a period but aren't sure you've started the menopausal transition, consider a pregnancy test. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is multiple-system-atrophy and explain in detail? [/INST] If your symtopms are extreme please call 911. Multiple system atrophy (MSA) affects many parts of your body. Symptoms usually start in adulthood, usually in the 50s or 60s. There are two types of MSA: parkinsonian and cerebellar. The type depends on the symptoms you have when you're diagnosed. MSA Parkinsonian type This is the most common type of MSA. The signs and symptoms are similar to those of Parkinson's disease, such as: MSA
Stiff muscles
Difficulty bending your arms and legs
Slow movement (bradykinesia)
Tremors can occur at rest or when moving your arms or legs
Soft voice
Problems with posture and balance
 Cerebellar type The main signs and symptoms are problems with muscle coordination (ataxia), but others may include:
Impaired movement and coordination, such as unsteady gait and loss of balance
Slurred, slow or low-volume speech (dysarthria)
Visual disturbances, such as blurred or double vision and difficulty focusing your eyes
Difficulty swallowing (dysphagia) or chewing
Changes in speech, such as slurred speech
 General signs and symptoms In addition, the primary sign of multiple system atrophy is autonomic failure, which may cause problems with body functions you can't control. This may include: Postural (orthostatic) hypotension Postural hypotension is a form of low blood pressure that makes you feel dizzy or lightheaded, or even faint, when you stand up from sitting or lying down. Not everyone with MSA has postural hypotension. MSA You can also develop dangerously high blood pressure levels while lying down (supine hypertension). Urinary and bowel dysfunction
Constipation
Loss of bladder or bowel control (incontinence)
 Changes in sweat production
Producing less sweat
Heat intolerance due to reduced sweating
Impaired body temperature control, often causing cold hands or feet
 Sleep disorders
Agitated sleep due to "acting out" dreams
Abnormal breathing at night or a harsh breathing sound (stridor)
 Sexual dysfunction
Inability to achieve or maintain an erection (impotence)
Loss of libido
 Cardiovascular problems
Color changes in hands and feet caused by pooling of blood
 Psychiatric problems
Difficulty controlling emotions, such as laughing or crying inappropriately
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is charcot-marie-tooth-disease and explain in detail? [/INST] If your symtopms are extreme please call 911. Signs and symptoms of Charcot-Marie-Tooth disease may include:
Weakness in your legs, ankles and feet
Loss of muscle bulk in your legs and feet
High foot arches
Curled toes (hammertoes)
Decreased ability to run
Difficulty lifting your foot at the ankle (footdrop)
Awkward or higher than normal step (gait)
Frequent tripping or falling
Decreased sensation or a loss of feeling in your legs and feet
 As Charcot-Marie-Tooth disease progresses, symptoms may spread from the feet and legs to the hands and arms. The severity of symptoms can vary greatly from person to person, even among family members. Causes Charcot-Marie-Tooth disease is an inherited, genetic condition. It occurs when there are mutations in the genes that affect the nerves in your feet, legs, hands and arms. Sometimes, these mutations damage the nerves. Other mutations damage the protective coating that surrounds the nerve (myelin sheath). Both cause weaker messages to travel between your limbs and brain. Risk factors Charcot-Marie-Tooth disease is hereditary, so you're at higher risk of developing the disorder if anyone in your immediate family has the disease. Other causes of neuropathies, such as diabetes, may cause symptoms similar to Charcot-Marie-Tooth disease. These other conditions can also cause the symptoms of Charcot-Marie-Tooth disease to become worse. Medications such as the chemotherapy drugs vincristine (Marqibo), paclitaxel (Abraxane) and others can make symptoms worse. Be sure to let your doctor know about all of the medications you're taking. Complications Complications of Charcot-Marie-Tooth disease vary in severity from person to person. Foot abnormalities and difficulty walking are usually the most serious problems. Muscles may get weaker, and you may injure areas of the body that experience decreased sensation. Sometimes the muscles in your feet may not receive your brain's signal to contract, so you're more likely to trip and fall. And your brain may not receive pain messages from your feet, so if you've rubbed a blister on your toe, for example, it may get infected without your realizing it. You may also experience difficulty breathing, swallowing or speaking if the muscles that control these functions are affected by Charcot-Marie-Tooth disease.

 By Mayo Clinic Staff By Mayo Clinic Staff Request an appointment Request an appointment   Diagnosis & treatment Diagnosis & treatment Diagnosis & treatment
    March 08, 2023
 Print Print  Share on: FacebookTwitter Facebook Twitter Show references
Klein CJ. Charcot-Marie-Tooth disease and other hereditary neuropathies. Continuum. 2020; doi:10.1212/CON.0000000000000927.
Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet. Accessed Dec. 31, 2020.
Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020.
Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Dec. 31, 2020.
Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/. Accessed Dec. 31, 2020.
Simon RP, et al. Sensory disorders. In: Clinical Neurology. 10th ed. McGraw-Hill; 2018. https://accessmedicine.mhmedical.com. Accessed Dec. 31, 2020.
Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020.
Rossor AM, et al. Are we prepared for clinical trials in Charcot-Marie-Tooth disease? Brain Research. 2020; doi:10.1016/j.brainres.2019.146625.
Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017; doi:10.1097/WCO. 0000000000000474.
Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/important-foot-care-for-people-with-cmt/. Accessed Dec. 31, 2020.
Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Dec. 31, 2020.
 Show references
Klein CJ. Charcot-Marie-Tooth disease and other hereditary neuropathies. Continuum. 2020; doi:10.1212/CON.0000000000000927.
Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet. Accessed Dec. 31, 2020.
Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020.
Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Dec. 31, 2020.
Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/. Accessed Dec. 31, 2020.
Simon RP, et al. Sensory disorders. In: Clinical Neurology. 10th ed. McGraw-Hill; 2018. https://accessmedicine.mhmedical.com. Accessed Dec. 31, 2020.
Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020.
Rossor AM, et al. Are we prepared for clinical trials in Charcot-Marie-Tooth disease? Brain Research. 2020; doi:10.1016/j.brainres.2019.146625.
Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017; doi:10.1097/WCO. 0000000000000474.
Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/important-foot-care-for-people-with-cmt/. Accessed Dec. 31, 2020.
Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Dec. 31, 2020.

Klein CJ. Charcot-Marie-Tooth disease and other hereditary neuropathies. Continuum. 2020; doi:10.1212/CON.0000000000000927.
Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet. Accessed Dec. 31, 2020.
Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020.
Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Dec. 31, 2020.
Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/. Accessed Dec. 31, 2020.
Simon RP, et al. Sensory disorders. In: Clinical Neurology. 10th ed. McGraw-Hill; 2018. https://accessmedicine.mhmedical.com. Accessed Dec. 31, 2020.
Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020.
Rossor AM, et al. Are we prepared for clinical trials in Charcot-Marie-Tooth disease? Brain Research. 2020; doi:10.1016/j.brainres.2019.146625.
Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017; doi:10.1097/WCO. 0000000000000474.
Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/important-foot-care-for-people-with-cmt/. Accessed Dec. 31, 2020.
Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Dec. 31, 2020.
 Klein CJ. Charcot-Marie-Tooth disease and other hereditary neuropathies. Continuum. 2020; doi:10.1212/CON.0000000000000927. Charcot-Marie-Tooth disease fact sheet. National Institute of Neurological Disorders and Stroke. https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Charcot-Marie-Tooth-Disease-Fact-Sheet. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Genetics, clinical features and diagnosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Facts about Charcot-Marie-Tooth disease and related diseases. Muscular Dystrophy Association. https://www.mda.org/disease/charcot-marie-tooth. Accessed Dec. 31, 2020. Neurotoxic medications. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/medications/. Accessed Dec. 31, 2020. Simon RP, et al. Sensory disorders. In: Clinical Neurology. 10th ed. McGraw-Hill; 2018. https://accessmedicine.mhmedical.com. Accessed Dec. 31, 2020. Kang PB. Charcot-Marie-Tooth disease: Management and prognosis. https://www.uptodate.com/contents/search. Accessed Dec. 31, 2020. Rossor AM, et al. Are we prepared for clinical trials in Charcot-Marie-Tooth disease? Brain Research. 2020; doi:10.1016/j.brainres.2019.146625. 2019.146625 2019.146625 Pareyson D, et al. New developments in Charcot-Marie-Tooth neuropathy and related diseases. Current Opinion in Neurology. 2017; doi:10.1097/WCO. 0000000000000474. Important foot care for people with CMT. Charcot-Marie-Tooth Association. https://www.cmtausa.org/living-with-cmt/managing-cmt/important-foot-care-for-people-with-cmt/. Accessed Dec. 31, 2020. Pedicure pointers. American Podiatric Medical Association. https://www.apma.org/Patients/HealthyFeetTips.cfm?ItemNumber=9859. Accessed Dec. 31, 2020.
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Charcot-Marie-Tooth diseaseSymptoms & causesDiagnosis & treatmentDoctors & departments
 Charcot-Marie-Tooth disease Symptoms & causesDiagnosis & treatmentDoctors & departments </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is parkinsons-disease and explain in detail? [/INST] If your symtopms are extreme please call 911. Parkinson's disease signs and symptoms can be different for everyone. Early signs may be mild and go unnoticed. Symptoms often begin on one side of the body and usually remain worse on that side, even after symptoms begin to affect the limbs on both sides. Parkinson's signs and symptoms may include:
Tremor. A tremor, or rhythmic shaking, usually begins in a limb, often your hand or fingers. You may rub your thumb and forefinger back and forth. This is known as a pill-rolling tremor. Your hand may tremble when it's at rest. The shaking may decrease when you are performing tasks.
Slowed movement (bradykinesia). Over time, Parkinson's disease may slow your movement, making simple tasks difficult and time-consuming. Your steps may become shorter when you walk. It may be difficult to get out of a chair. You may drag or shuffle your feet as you try to walk.
Rigid muscles. Muscle stiffness may occur in any part of your body. The stiff muscles can be painful and limit your range of motion.
Impaired posture and balance. Your posture may become stooped. Or you may fall or have balance problems as a result of Parkinson's disease.
Loss of automatic movements. You may have a decreased ability to perform unconscious movements, including blinking, smiling or swinging your arms when you walk.
Speech changes. You may speak softly, quickly, slur or hesitate before talking. Your speech may be more of a monotone rather than have the usual speech patterns.
Writing changes. It may become hard to write, and your writing may appear small.
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is vaginitis and explain in detail? [/INST] If your symtopms are extreme please call 911. Vaginitis signs and symptoms can include:
Change in color, odor or amount of discharge from your vagina
Vaginal itching or irritation
Pain during sex
Painful urination
Light vaginal bleeding or spotting
 If you have vaginal discharge, the characteristics of the discharge might indicate the type of vaginitis you have. Examples include:
Bacterial vaginosis. You might develop a grayish-white, foul-smelling discharge. The odor, often described as a fishy odor, might be more obvious after sex.
Yeast infection. The main symptom is itching, but you might have a thick white discharge that resembles cottage cheese.
Trichomoniasis. An infection called trichomoniasis (trik-o-moe-NIE-uh-sis) can cause a greenish-yellow, sometimes frothy discharge.
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is juvenile-idiopathic-arthritis and explain in detail? [/INST] If your symtopms are extreme please call 911. The most common signs and symptoms of juvenile idiopathic arthritis are:
Pain. While your child might not complain of joint pain, you may notice that he or she limps — especially first thing in the morning or after a nap.
Swelling. Joint swelling is common but is often first noticed in larger joints such as the knee.
Stiffness. You might notice that your child appears clumsier than usual, particularly in the morning or after naps.
Fever, swollen lymph nodes and rash. In some cases, high fever, swollen lymph nodes or a rash on the trunk may occur — which is usually worse in the evenings.
 Juvenile idiopathic arthritis can affect one joint or many. There are several different subtypes of juvenile idiopathic arthritis, but the main ones are systemic, oligoarticular and polyarticular. Which type your child has depends on symptoms, the number of joints affected, and if a fever and rashes are prominent features. Like other forms of arthritis, juvenile idiopathic arthritis is characterized by times when symptoms flare up and times when symptoms may be minimal. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is hamstring-injury and explain in detail? [/INST] If your symtopms are extreme please call 911. A hamstring injury typically causes a sudden, sharp pain in the back of the thigh. There might also be a "popping" or tearing sensation. Swelling and tenderness usually develop within a few hours. There might be bruising or a change in skin color along the back of the leg. Some people have muscle weakness or are not able to put weight on the injured leg. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is trichomoniasis and explain in detail? [/INST] If your symtopms are extreme please call 911. Most people with trichomoniasis have no signs or symptoms. However, symptoms may develop over time. When signs and symptoms develop, they are different for men and women. In women, trichomoniasis signs and symptoms include:
A large amount of a thin, often foul-smelling discharge from the vagina — which might be clear, white, gray, yellow or green
Genital redness, burning and itching
Pain with urination or sex
Discomfort over the lower stomach area
 In men, trichomoniasis rarely causes symptoms. When men do have signs and symptoms, however, they might include:
Itching or irritation inside the penis
Burning with urination or after ejaculation
Discharge from the penis
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is polycythemia-vera and explain in detail? [/INST] If your symtopms are extreme please call 911. Many people with polycythemia vera don't have noticeable signs or symptoms. Some people might develop vague symptoms such as headache, dizziness, fatigue and blurred vision. More-specific symptoms of polycythemia vera include:
Itchiness, especially after a warm bath or shower
Numbness, tingling, burning, or weakness in your hands, feet, arms or legs
A feeling of fullness soon after eating and bloating or pain in your left upper abdomen due to an enlarged spleen
Unusual bleeding, such as a nosebleed or bleeding gums
Painful swelling of one joint, often the big toe
Shortness of breath and difficulty breathing when lying down
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is bed-wetting and explain in detail? [/INST] If your symtopms are extreme please call 911. Most kids are fully toilet trained by age 5, but there's really no target date for developing complete bladder control. Between the ages of 5 and 7, bed-wetting remains a problem for some children. After 7 years of age, a small number of children still wet the bed. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is chronic-exertional-compartment-syndrome and explain in detail? [/INST] If your symtopms are extreme please call 911. Your limbs have specific areas of muscle (compartments). Your lower leg, for example, has four compartments. Chronic exertional compartment syndrome often occurs in the same compartment of an affected limb on both sides of the body, usually the lower leg. Signs and symptoms can include:
Aching, burning or cramping pain in a compartment of the affected limb
Tightness in the affected limb
Numbness or tingling in the affected limb
Weakness of the affected limb
Foot drop, in severe cases, if legs are affected
Occasionally, swelling or bulging as a result of a muscle hernia
 Pain caused by chronic exertional compartment syndrome typically follows this pattern:
Begins consistently after a certain time, distance or intensity of exertion after you start exercising the affected limb
Progressively worsens as you exercise
Becomes less intense or stops completely within 15 minutes of stopping the activity
Over time, recovery time after exercise may increase
 Taking a complete break from exercise or performing only low-impact activity might relieve your symptoms, but relief is usually only temporary. Once you take up running again, for instance, those familiar symptoms usually come back. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is hepatitis-a and explain in detail? [/INST] If your symtopms are extreme please call 911. Hepatitis A symptoms typically appear a few weeks after you've had the virus. But not everyone with hepatitis A develops symptoms. If you do, symptoms can include:
Unusual tiredness and weakness
Sudden nausea and vomiting and diarrhea
Abdominal pain or discomfort, especially on the upper right side beneath your lower ribs, which is over your liver
Clay- or gray-colored stool
Loss of appetite
Low-grade fever
Dark urine
Joint pain
Yellowing of the skin and the whites of your eyes (jaundice)
Intense itching
 These symptoms may be relatively mild and go away in a few weeks. Sometimes, however, hepatitis A results in a severe illness that lasts several months. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is seborrheic-dermatitis and explain in detail? [/INST] If your symtopms are extreme please call 911. Seborrheic dermatitis signs and symptoms may include:
Flaking skin (dandruff) on your scalp, hair, eyebrows, beard or mustache
Patches of greasy skin covered with flaky white or yellow scales or crust on the scalp, face, sides of the nose, eyebrows, ears, eyelids, chest, armpits, groin area or under the breasts
Rash that may look darker or lighter in people with brown or Black skin and redder in those with white skin
Ring-shaped (annular) rash, for a type called petaloid seborrheic dermatitis
Itchiness (pruritus)
 The signs and symptoms of seborrheic dermatitis tend to flare with stress, fatigue or a change of season. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is peptic-ulcer and explain in detail? [/INST] If your symtopms are extreme please call 911.
Burning stomach pain
Feeling of fullness, bloating or belching
Intolerance to fatty foods
Heartburn
Nausea
 The most common peptic ulcer symptom is burning stomach pain. Stomach acid makes the pain worse, as does having an empty stomach. The pain can often be relieved by eating certain foods that buffer stomach acid or by taking an acid-reducing medication, but then it may come back. The pain may be worse between meals and at night. Many people with peptic ulcers don't even have symptoms. Less often, ulcers may cause severe signs or symptoms such as:
Vomiting or vomiting blood — which may appear red or black
Dark blood in stools, or stools that are black or tarry
Trouble breathing
Feeling faint
Nausea or vomiting
Unexplained weight loss
Appetite changes
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is pancreatic-neuroendocrine-tumors and explain in detail? [/INST] If your symtopms are extreme please call 911. Pancreatic neuroendocrine tumors sometimes don't cause symptoms. When they do, signs and symptoms can include:
Stomach ulcers
Heartburn
Diabetes
Weakness
Fatigue
Muscle cramps
Indigestion
Diarrhea
Weight loss
Skin rash
Constipation
Pain in your abdomen or back
Yellowing of your skin or eyes
Low blood sugar
 Causes It's not clear what causes most pancreatic neuroendocrine tumors. Pancreatic neuroendocrine tumors occur when hormone-producing cells in the pancreas (islet cells) develop changes (mutations) in their DNA — the material that provides instructions for every chemical process in your body. DNA mutations cause changes in these instructions. One result is that cells may begin to grow out of control and eventually form a tumor — a mass of cancerous cells. Sometimes the cancer cells break away and spread to other organs, such as the liver. Some inherited syndromes increase the risk of this type of cancer, including:
Multiple endocrine neoplasia, type 1 (MEN 1) syndrome
Von Hippel-Lindau disease
Von Recklinghausen's disease (neurofibromatosis 1)
Tuberous sclerosis
 Risk factors Factors that are associated with an increased risk of pancreatic neuroendocrine tumors include:
Being male. Men are much more likely than women to develop these tumors.
A family history of pancreatic neuroendocrine tumors. If a family member was diagnosed with pancreatic neuroendocrine tumor, your risk is increased. You may have multiple endocrine neoplasia, type 1 (MEN 1) syndrome, which increases the risk of this type of tumor.

 By Mayo Clinic Staff By Mayo Clinic Staff
Pancreatic neuroendocrine tumors care at Mayo Clinic
 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is leukoplakia and explain in detail? [/INST] If your symtopms are extreme please call 911. Leukoplakia usually occurs on your gums, the insides of your cheeks, the bottom of your mouth — beneath the tongue — and, sometimes, your tongue. It isn't usually painful and may go unnoticed for a while. Leukoplakia may appear:
White or grayish in patches that can't be wiped away
Irregular or flat-textured
Thickened or hardened in areas
Along with raised, red lesions (speckled leukoplakia or erythroplakia), which are more likely to show precancerous changes
 Hairy leukoplakia Hairy leukoplakia causes fuzzy, white patches that resemble folds or ridges, usually on the sides of your tongue. It's often mistaken for oral thrush, an infection marked by creamy white patches that can be wiped away, which is also common in people with a weakened immune system. When to see a doctor Even though leukoplakia doesn't usually cause discomfort, sometimes it can indicate a more serious condition. See your dentist or primary care professional if you have any of the following:
White plaques or sores in your mouth that don't heal on their own within two weeks

Lumps or white, red or dark patches in your mouth

Persistent changes in the tissues of your mouth

Ear pain when swallowing

Progressive reduction in the ability to open your jaw

 </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is pemphigus and explain in detail? [/INST] If your symtopms are extreme please call 911. Pemphigus causes blisters on your skin and mucous membranes. The blisters rupture easily, leaving open sores, which may ooze and become infected. The signs and symptoms of two common types of pemphigus are as follows:
Pemphigus vulgaris. This type usually begins with blisters in your mouth and then on your skin or genital mucous membranes. The blisters typically are painful but don't itch. Blisters in your mouth or throat may make it hard to swallow and eat.
Pemphigus foliaceus. This type causes blisters on the chest, back and shoulders. The blisters tend to be more itchy than painful. Pemphigus foliaceus doesn't cause mouth blisters.
 Pemphigus is distinct from bullous pemphigoid, which is a blistering skin condition that affects older adults and may cause death. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is acoustic-neuroma and explain in detail? [/INST] If your symtopms are extreme please call 911. Signs and symptoms of acoustic neuroma are often easy to miss and may take many years to develop. They usually happen because of the tumor's effects on the hearing and balance nerves. Pressure from the tumor on nearby nerves controlling facial muscles and sensation (facial and trigeminal nerves), nearby blood vessels, or brain structures may also cause problems. As the tumor grows, it may cause more noticeable or severe signs and symptoms. Common signs and symptoms of acoustic neuroma include:
Hearing loss, usually gradually worsening over months to years — although in rare cases sudden — and occurring on only one side or more severe on one side
Ringing (tinnitus) in the affected ear
Unsteadiness or loss of balance
Dizziness (vertigo)
Facial numbness and weakness or loss of muscle movement
 In rare cases, an acoustic neuroma may grow large enough to compress the brainstem and become life-threatening. When to see your doctor See your doctor if you notice hearing loss in one ear, ringing in your ear or trouble with your balance. Early diagnosis of an acoustic neuroma may help keep the tumor from growing large enough to cause serious consequences, such as total hearing loss. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is microcephaly and explain in detail? [/INST] If your symtopms are extreme please call 911. The primary symptom of microcephaly is having a head size that is much smaller than that of other children of the same age and sex. Head size is a measure of the distance around the top of the child's head (circumference). Using standardized growth charts, health care providers compare the measurement with other children's measurements in percentiles. Some children just have small heads, with a measurement that falls below an established value for children of the same age and sex. In children with microcephaly, head size measures much smaller than average for the child's age and sex. A child with more-severe microcephaly may also have a sloping forehead. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is dislocated-shoulder and explain in detail? [/INST] If your symtopms are extreme please call 911.

	    Shoulder dislocation
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Shoulder dislocation

Shoulder dislocation
The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation.

	    Shoulder dislocation
	    Open pop-up dialog box

	    Shoulder dislocation
	    Open pop-up dialog box
 Open pop-up dialog box

Close

Shoulder dislocation

Shoulder dislocation
The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation.

Close

Shoulder dislocation

Shoulder dislocation
The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation.

Close

Shoulder dislocation

Shoulder dislocation
The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation.

Close

Close
 Close Shoulder dislocation
Shoulder dislocation
The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation.
 Shoulder dislocation The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. The shoulder joint is the most frequently dislocated joint of the body. Because it moves in several directions, your shoulder can dislocate forward, backward or downward. The most common variety is a forward (anterior) dislocation. Dislocated shoulder symptoms can include:
A visibly deformed or out-of-place shoulder
Swelling or bruising
Intense pain
Inability to move the joint
 Shoulder dislocation can also cause numbness, weakness or tingling near the injury, such as in the neck or down the arm. The muscles in the shoulder might spasm, which can increase the pain. </s>


<s> [INST] <<SYS>> You are a helpful, respectful, and honest assistant. Always answer as helpfully as possible, while being safe. Your answers should not include any harmful, unethical, racist, sexist, toxic, dangerous, or illegal content. Please ensure that your responses are socially unbiased and positive in nature. If a question does not make any sense or is not factually coherent, explain why instead of answering something not correct. If you don't know the answer to a question, please don't share false information. <</SYS>> I am not feeling to well and am trying to figure out what could be wrong. What is gestational-diabetes and explain in detail? [/INST] If your symtopms are extreme please call 911. Most of the time, gestational diabetes doesn't cause noticeable signs or symptoms. Increased thirst and more-frequent urination are possible symptoms. </s>