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How should the interaction between Quazepam and Olopatadine (nasal) be managed? Describe the necessary steps. | Concomitant use of olopatadine nasal spray with alcohol or other CNS depressants should generally be avoided if possible. In the event that they are used together, patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their doctor if they experience excessive or prolonged CNS effects that interfere with their normal activities. | 109,556 |
What is the interaction between Phenytoin and Cyclophosphamide? | Coadministration with phenytoin may result in significantly decreased plasma concentrations of cyclophosphamide and thiotepa, while concentrations of their main active metabolites increase. The proposed mechanism is induction of CYP450 2B6 metabolism by phenytoin.
abdominal distension abdominal pain Anorexia aphasia ascites aspergillosis atelectasis Bacterial infection Clotting bone marrow transplant More | 442,296 |
Explain the mechanism of interaction between Nilotinib and Clobazam. | Metabolism | 960,061 |
Explain the mechanism of interaction between Cilostazol and Tramadol. | Synergy | 64,044 |
What is the severity level of interaction between Lofexidine and Naltrexone? | Moderate | 43,585 |
What is the interaction between Nortriptyline and Cyclobenzaprine? | Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1 receptor agonists, ergot alkaloids, cyclobenzaprine, lithium, St. John's wort, phenylpiperidine opioids, dextromethorphan, and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucination, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.
abdominal pain birth defect abscess agnosia alopecia Amnesia Anorexia Anxiety aortic stenosis aphasia More | 415,515 |
What is the severity level of interaction between Betaxolol and Reserpine? | Moderate | 379,989 |
What is the severity level of interaction between Etonogestrel and Rifapentine? | Major | 861,882 |
What is the interaction between Acebutolol and Tizanidine? | Tizanidine may potentiate the hypotensive effect of some medications secondary to its alpha-2 adrenergic activity. Pharmacologic studies have found tizanidine to possess between 1/10 to 1/50 of the potency of clonidine, a structurally similar agent, in lowering blood pressure. | 999,238 |
What is the severity level of interaction between Metronidazole and Clozapine? | Minor | 1,373,343 |
What is the severity level of interaction between Brigatinib and Bepridil? | Moderate | 1,213,475 |
What is the severity level of interaction between Voriconazole and Abiraterone? | Moderate | 773,290 |
Explain the mechanism of interaction between Mivacurium and Prednisone. | Others | 1,246,862 |
How should the interaction between Alectinib and Ozanimod be managed? Describe the necessary steps. | Ozanimod has not been adequately studied in patients receiving concomitant therapy with drugs that decrease heart rate. In addition, advice from a cardiologist should be sought if coadministration of ozanimod is considered in patients with significant QT prolongation (QTcF greater than 450 msec in males or 470 msec in females), patients with arrhythmias requiring treatment with Class 1a or Class III antiarrhythmic agents, patients with ischemic heart disease, heart failure, history of cardiac arrest or myocardial infarction, cerebrovascular disease, or uncontrolled hypertension. Use of ozanimod in patients with a history of second-degree Mobitz type II or higher AV block, sick-sinus syndrome, or sinoatrial heart block is considered contraindicated unless the patient has a functioning pacemaker. | 973,548 |
What is the interaction between Idarubicin and Yellow Fever Vaccine? | The administration of live, attenuated viral or bacterial vaccines during immunosuppressant or intense antineoplastic therapy may be associated with a risk of disseminated infection due to enhanced replication of vaccine virus or bacteria in the presence of diminished immune competence. Patients may be immunosuppressed if they have recently received or are receiving alkylating agents, antimetabolites, radiation, some antirheumatic agents, high dosages of corticosteroids or adrenocorticotropic agents, or long-term topical or inhaled corticosteroids. These patients may also have increased adverse reactions and decreased or suboptimal immunologic response to vaccines. | 1,154,454 |
What is the severity level of interaction between Acetaminophen and Carbamazepine? | Moderate | 735,716 |
How should the interaction between Flucytosine and Flurbiprofen be managed? Describe the necessary steps. | Caution is advised if flucytosine is used in patients who have recently received or are receiving treatment with potentially nephrotoxic drugs (e.g., aminoglycosides; polypeptide, glycopeptide, and polymyxin antibiotics; amphotericin B; adefovir; cidofovir; tenofovir; foscarnet; cisplatin; deferasirox; gallium nitrate; lithium; mesalamine; certain immunosuppressants; intravenous bisphosphonates; intravenous pentamidine; high intravenous dosages of methotrexate; high dosages and/or chronic use of nonsteroidal anti-inflammatory agents). | 874,371 |
How should the interaction between Tetracycline and Magnesium carbonate be managed? Describe the necessary steps. | The administration of tetracyclines and preparations containing aluminum, magnesium, or calcium should be separated by two to four hours. | 1,159,263 |
Explain the mechanism of interaction between Conivaptan and Bromocriptine. | Metabolism | 1,233,916 |
How should the interaction between Ambrisentan and Nefazodone be managed? Describe the necessary steps. | - | 1,170,672 |
Explain the mechanism of interaction between Promethazine and Rolapitant. | Metabolism | 772,838 |
What is the severity level of interaction between Insulin lispro (protamine) and Asparaginase Erwinia chrysanthemi? | Moderate | 1,098,591 |
What is the interaction between Drotrecogin alfa and Rivaroxaban? | Coadministration of drotrecogin alfa and other drugs that interfere with coagulation or platelet function may potentiate the risk of bleeding complications. Drotrecogin alfa inactivates blood clotting factors Va and VIIIa and may prolong the activated partial thromboplastin time (APTT). Treatment with drotrecogin alfa alone has been associated with serious and life-threatening bleeding episodes, including gastrointestinal, intracranial and retroperitoneal hemorrhage, although most severely ill septic patients are already at a high risk of bleeding because of coagulopathies associated with prolonged APTT and prothrombin time (PT). | 769,598 |
Explain the mechanism of interaction between Aldesleukin and Clobazam. | Synergy | 253,618 |
How should the interaction between Satralizumab and Trichophyton mentagrophytes be managed? Describe the necessary steps. | Clinicians should be aware of the potential for falsely insignificant or false-negative results when administering diagnostic skin test antigens to patients treated with immunosuppressive agents. | 122,409 |
What is the severity level of interaction between Iopamidol and Tacrolimus? | Major | 218,969 |
What is the severity level of interaction between Diiodohydroxyquinoline and Vinorelbine? | Moderate | 1,266,702 |
Explain the mechanism of interaction between Tolbutamide and Gatifloxacin. | Antagonism | 917,710 |
Explain the mechanism of interaction between Verapamil and Amobarbital. | Metabolism | 1,167,752 |
What is the interaction between Dalfampridine and Prochlorperazine? | The concomitant use of dalfampridine with drugs that are inhibitors of organic cation transporter 2 (OCT2) may theoretically reduce its renal clearance. Dalfampridine is primarily eliminated through renal excretion, approximately 60% of which is via active secretion by OCT2. Elevated levels of dalfampridine may increase the risk of CNS excitation and seizures. | 615,270 |
How should the interaction between Dalteparin and Capsicum be managed? Describe the necessary steps. | - | 897,421 |
What is the severity level of interaction between Indinavir and Cabozantinib? | Major | 623,094 |
Explain the mechanism of interaction between Primaquine and Gilteritinib. | Synergy | 1,039,577 |
What is the interaction between Fenofibrate and Vardenafil? | Coadministration with inhibitors of CYP450 3A4 and/or 2C9 may increase the plasma concentrations of vardenafil, which is primarily metabolized by the former and secondarily by the latter. The possibility of prolonged and/or increased pharmacologic effects of vardenafil should be considered.
agnosia Amnesia aneurysm Anxiety Aching joints asthenia chest pain diarrhea dizziness dyspepsia More | 214,020 |
What is the interaction between Penbutolol and Sodium oxybate? | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis. | 184,064 |
What is the severity level of interaction between Berotralstat and Trazodone? | Moderate | 1,206,914 |
What is the severity level of interaction between Amphotericin B and Clotrimazole? | Minor | 139,182 |
Explain the mechanism of interaction between Nitroglycerin and Bupropion. | Synergy | 491,234 |
What is the interaction between Alimemazine and Fingolimod? | Due to its significant bradycardic effects, the risk of QT prolongation and torsade de pointes arrhythmia may be increased during initiation of fingolimod treatment in patients receiving drugs that prolong the QT interval. Fingolimod can cause a decrease in heart rate during initiation of therapy that is apparent within an hour of the first dose and maximal at approximately 6 hours postdose in most cases, but occasionally up to 20 hours after the first dose. | 201,664 |
Explain the mechanism of interaction between Brivaracetam and Nortriptyline. | Synergy | 894,498 |
What is the interaction between Salsalate and Prednisone? | Coadministration with corticosteroids may decrease the serum concentrations and therapeutic effects of salicylates. Likewise, serum salicylate levels may increase following withdrawal of corticosteroid therapy, potentially resulting in salicylate toxicity. Pharmacologically, the potential for increased gastrointestinal (GI) toxicity, including inflammation, bleeding, ulceration and perforation, should be considered due to additive ulcerogenic effects of these agents (especially aspirin) on the GI mucosa. | 24,538 |
What is the interaction between Levamlodipine and Calcium lactate? | Calcium-containing products may decrease the effectiveness of calcium channel blockers by saturating calcium channels with calcium. Calcium chloride has been used to manage acute severe verapamil toxicity. | 1,321,685 |
What is the interaction between Isradipine and Iothalamic acid? | Coadministration of calcium channel blockers may increase the cardiovascular effects of ionic X-ray contrast media. The mechanism is unknown. | 489,570 |
Explain the mechanism of interaction between Paclitaxel (protein-bound) and Simeprevir. | Absorption | 913,910 |
How should the interaction between Phenelzine and Butorphanol be managed? Describe the necessary steps. | Narcotic analgesics should generally not be used with MAOIs or other agents that possess MAOI activity (e.g., furazolidone, linezolid, methylene blue, procarbazine). At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with opioids. However, morphine has been safely used in MAOI-treated patients who previously had an adverse reaction with meperidine and is generally suggested as an alternative to meperidine in anesthesia. A sensitivity test should be performed in which repeated, small, incremental doses of morphine are administered over the course of several hours while overall clinical status and vital signs are carefully monitored. | 351,279 |
What is the severity level of interaction between Oxazepam and Ethotoin? | Moderate | 838,688 |
How should the interaction between Aldesleukin and Cenobamate be managed? Describe the necessary steps. | Caution is advised if aldesleukin is used with sedatives, hypnotics, tranquilizers, or other CNS-active medications. Patients should be monitored for CNS depression and other CNS adverse effects. Treatment with aldesleukin should be discontinued if severe lethargy or somnolence develop. | 996,107 |
Explain the mechanism of interaction between Primidone and Brigatinib. | Metabolism | 1,079,111 |
What is the severity level of interaction between Tetracaine (topical) and Isosorbide dinitrate? | Moderate | 1,333,382 |
What is the interaction between Sorafenib and Olanzapine? | It is uncertain whether olanzapine causes clinically significant prolongation of the QT interval. | 628,776 |
How should the interaction between Etidronic acid and Neomycin be managed? Describe the necessary steps. | Caution is advised if bisphosphonates are used in patients who have recently received or are receiving treatment with aminoglycosides. Renal function as well as serum calcium and magnesium levels should be monitored during and after treatment, since renal loss of calcium and magnesium can continue for many weeks after cessation of aminoglycosides, as can the effect of bisphosphonates. Patients and clinicians should be alert to signs and symptoms of clinical hypocalcemia such as muscle spasms, carpopedal spasm, laryngeal spasm, tetany, convulsions, mental changes (irritability, depression, psychosis), increased intracranial pressure, papilledema, QT interval prolongation, and cardiac arrhythmias. | 850,937 |
How should the interaction between Aldesleukin and Procarbazine be managed? Describe the necessary steps. | Caution is advised during coadministration of MAOIs and other medications with hypotensive effects, especially during the first few weeks of treatment. Close monitoring for development of hypotension is recommended. Ambulatory patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. | 288,998 |
Explain the mechanism of interaction between Prednisolone (ophthalmic) and Voxelotor. | Metabolism | 134,633 |
How should the interaction between Brexpiprazole and Darunavir be managed? Describe the necessary steps. | The manufacturer recommends that the brexpiprazole dosage be reduced as follows during concomitant administration of CYP450 inhibitors. The brexpiprazole dosage should be increased to the original level if these agents are discontinued. It is advisable to monitor patients for clinical response. | 1,349,380 |
How should the interaction between Tazemetostat and Ivacaftor be managed? Describe the necessary steps. | Caution and clinical monitoring is recommended with the concomitant use of tazemetostat with CYP450 3A4 inhibitors. Patients should be advised to notify their health care professional if they experience signs or symptoms of possible tazemetostat-related adverse effects including secondary malignancies, hemorrhage, pleural effusion, skin infection, dyspnea, pain, and respiratory distress. | 12,666 |
What is the interaction between Bumetanide and Glipizide? | The efficacy of insulin and other antidiabetic agents may be diminished by certain drugs, including atypical antipsychotics, corticosteroids, diuretics, estrogens, gonadotropin-releasing hormone agonists, human growth hormone, phenothiazines, progestins, protease inhibitors, sympathomimetic amines, thyroid hormones, L-asparaginase, alpelisib, copanlisib, danazol, diazoxide, isoniazid, megestrol, omacetaxine, phenytoin, tagraxofusp, temsirolimus, as well as pharmacologic dosages of nicotinic acid and adrenocorticotropic agents. These drugs may interfere with blood glucose control because they can cause hyperglycemia, glucose intolerance, new-onset diabetes mellitus, and/or exacerbation of preexisting diabetes.
abdominal distension abdominal pain adenocarcinoma allergic rhinitis Amnesia anaemia angina Apnea Arrhythmia arteriosclerosis More | 1,177,888 |
What is the interaction between Nelarabine and Tofacitinib? | Coadministration of tofacitinib with other immuno- or myelosuppressive agents may potentiate the risk of infections as well as lymphoma and other malignancies. Serious and sometimes fatal infections due to bacterial, mycobacterial, invasive fungal, viral, or other opportunistic pathogens have been reported in patients receiving tofacitinib, most of whom were taking concomitant immunosuppressants such as methotrexate or corticosteroids. Lymphoma and other malignancies have also been observed with tofacitinib use, with or without concomitant immunosuppressants. | 586,146 |
How should the interaction between Kaolin and Hydrocodone be managed? Describe the necessary steps. | If concomitant use cannot be avoided, patients should be monitored for potentially excessive or prolonged CNS depression and constipation. | 13,986 |
How should the interaction between Aminolevulinic acid (topical) and Ciprofloxacin be managed? Describe the necessary steps. | Caution is advised and pharmacologic response to photodynamic therapy should be carefully monitored if concomitant use of other photosensitizing agents cannot be avoided. Patients should be advised to avoid exposure of treated areas to sunlight or bright indoor lights (e.g., examination lamps, operating room lamps, tanning beds, lights at close proximity) during the period between application of aminolevulinic acid or methyl aminolevulinate and photoactivation, and for 48 hours post-illumination. Concomitant use with other topical medicinal products should be avoided. | 1,350,224 |
Explain the mechanism of interaction between Olsalazine and Ioxilan. | Synergy | 480,754 |
How should the interaction between Ketorolac and Acetylsalicylic acid be managed? Describe the necessary steps. | Concurrent use of ketorolac with other NSAIDs or aspirin is considered contraindicated. | 136,330 |
Explain the mechanism of interaction between Rocuronium and Spectinomycin. | Synergy | 648,663 |
What is the severity level of interaction between Temozolomide and Imatinib? | Moderate | 133,767 |
What is the interaction between Physostigmine and Pyridostigmine? | A synergistic effect may be expected when acetylcholinesterase inhibitors are administered concurrently with other cholinesterase inhibitors or cholinergic agonists. | 1,168,727 |
What is the interaction between Palbociclib and Itraconazole? | Coadministration with potent inhibitors of CYP450 3A4 may increase the plasma concentrations of palbociclib, which is a substrate of the isoenzyme. The risk of adverse effects such as infections, neutropenia, leukopenia, anemia, thrombocytopenia, anorexia, nausea, vomiting, diarrhea, stomatitis, alopecia, asthenia, peripheral neuropathy, and epistaxis may be increased. | 264,712 |
Explain the mechanism of interaction between Levacetylmethadol and Gilteritinib. | Synergy | 302,918 |
How should the interaction between Trifluoperazine and Methocarbamol be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 48,984 |
Explain the mechanism of interaction between Ramucirumab and Urokinase. | Synergy | 978,732 |
What is the severity level of interaction between Ceritinib and Gefitinib? | Moderate | 1,285,160 |
What is the severity level of interaction between Dofetilide and Rifabutin? | Minor | 516,588 |
What is the severity level of interaction between Metamfetamine and Levomilnacipran? | Major | 926,075 |
What is the interaction between Ribociclib and Dalfopristin? | Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations and risk of adverse effects of ribociclib, which is a substrate of the isoenzyme. Administration of erythromycin, a moderate CYP450 3A4 inhibitor, is predicted to increase ribociclib Cmax and AUC by 1.3- and 1.9-fold, respectively. | 432,315 |
Explain the mechanism of interaction between Ivabradine and Terfenadine. | Synergy | 742,139 |
What is the severity level of interaction between Promethazine and Eplerenone? | Moderate | 1,322,905 |
What is the interaction between Revefenacin and Chlorcyclizine? | The potential exists for additive anticholinergic effects such as mydriasis, blurred vision, heat intolerance, fever, dry mouth, tachycardia, urinary retention, constipation, and glaucoma (onset or exacerbation) when topical or inhaled anticholinergic agents are used with each other or with other agents that possess anticholinergic properties. The risk of systemic anticholinergic effects following topical administration depends on variables such as strength of the product, size of the application area, frequency of application, and use of occlusive dressing. Systemic effects are uncommon following oral inhalation or nasal administration due to the poor absorption of quaternary ammonium compounds from gastrointestinal and nasal mucosa. | 533,556 |
Explain the mechanism of interaction between Mogamulizumab and Strontium chloride Sr-89. | Synergy | 607,086 |
Explain the mechanism of interaction between Dimethyl fumarate and Rubella virus vaccine. | Others | 1,072,876 |
How should the interaction between Daunorubicin (liposomal) and Telaprevir be managed? Describe the necessary steps. | Caution is advised if daunorubicin or idarubicin is prescribed in combination with a P-gp inhibitor. Patients should be closely monitored for increased adverse effects including cardiotoxicity and myelosuppression. | 23,247 |
Explain the mechanism of interaction between Conivaptan and Ketoconazole. | Metabolism | 1,269,460 |
Explain the mechanism of interaction between Apomorphine and Escitalopram. | Synergy | 579,879 |
How should the interaction between Aurothioglucose and Linezolid be managed? Describe the necessary steps. | Patients should be monitored closely for symptoms of neuropathy such as burning, tingling, pain, or numbness in the hands and feet. Since the development of peripheral neuropathy may be dose-related for many drugs, the recommended dosages should generally not be exceeded. Consideration should be given to dosage reduction or immediate discontinuation of these medications in patients who develop peripheral neuropathy to limit further damage. | 1,007,293 |
Explain the mechanism of interaction between Selexipag and Valproic acid. | Metabolism | 1,311,736 |
What is the severity level of interaction between Benzhydrocodone and Secukinumab? | Moderate | 782,038 |
How should the interaction between Fluoxetine and Triptorelin be managed? Describe the necessary steps. | The benefits of androgen deprivation therapy should be carefully assessed against the potential risk in patients receiving other drugs known to prolong the QT interval. Electrolyte abnormalities should be corrected prior to initiating therapy, and periodic monitoring of electrocardiograms and electrolytes should be considered. | 564,685 |
How should the interaction between Fosphenytoin and Dihydrotachysterol be managed? Describe the necessary steps. | Patients receiving vitamin D analogs with CYP450 inducers should be monitored for potentially reduced vitamin D effects. Dosage adjustments may be necessary. | 487,879 |
What is the interaction between Salmeterol and Epirubicin? | Beta-2 adrenergic agonists can cause dose-related prolongation of the QT interval and potassium loss. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. Clinically significant prolongation of QT interval and hypokalemia occur infrequently when beta-2 agonists are inhaled at normally recommended dosages. However, these effects may be more common when the drugs are administered systemically or when recommended dosages are exceeded. | 950,110 |
Explain the mechanism of interaction between Brompheniramine and Pitolisant. | Antagonism | 1,046,797 |
How should the interaction between Norfloxacin and Glipizide be managed? Describe the necessary steps. | Blood glucose should be closely monitored whenever quinolones are prescribed to diabetic patients, especially if they are elderly, have renal impairment, or are severely ill. Due to the risk of profound and potentially life-threatening hypoglycemia, particular caution is advised during concomitant use of insulin and insulin secretagogues (e.g., sulfonylureas, meglitinides). Patients should also be apprised of the increased risk of hypoglycemia and be alert to potential signs and symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, palpitation, and tachycardia. If hypoglycemia occurs, patients should initiate appropriate remedial therapy immediately, discontinue the quinolone, and contact their physician. Alternative antibiotics may need to be considered. | 1,271,741 |
What is the severity level of interaction between Atorvastatin and Simvastatin? | Moderate | 561,353 |
Explain the mechanism of interaction between Pramlintide and Trihexyphenidyl. | Absorption | 196,769 |
Explain the mechanism of interaction between Infliximab and Pitavastatin. | Synergy | 202,283 |
What is the severity level of interaction between Primaquine and Foscarnet? | Moderate | 989,913 |
What is the interaction between Cangrelor and Ketorolac (ophthalmic)? | Systemically and topically administered nonsteroidal anti-inflammatory drugs (NSAIDs) may potentiate the risk of bleeding in patients treated with anticoagulants and other drugs that affect hemostasis such as platelet inhibitors, thrombin inhibitors, thrombolytic agents, or agents that commonly cause thrombocytopenia. The pharmacologic effects of NSAIDs that contribute to this interaction include prolongation of prothrombin time and inhibition of platelet adhesion and aggregation. | 271,836 |
How should the interaction between Glycerol phenylbutyrate and Midodrine be managed? Describe the necessary steps. | Caution is recommended if glycerol phenylbutyrate is administered with medicines that are substrates of CYP450 2D6, such as codeine, dextromethorphan, and some beta blockers (including metoprolol, carvedilol, labetalol, propranolol, and nebivolol). Dosage adjustments as well as clinical and laboratory monitoring may be appropriate. | 1,220,405 |
Explain the mechanism of interaction between Lonafarnib and Dexamethasone (nasal). | Metabolism | 1,363,715 |
Explain the mechanism of interaction between Ethotoin and Fluconazole. | Metabolism | 208,261 |
What is the severity level of interaction between Protriptyline and Brimonidine (topical)? | Moderate | 805,889 |
What is the severity level of interaction between Quinidine and Lisdexamfetamine? | Major | 460,337 |
How should the interaction between Sulfadiazine and Idelalisib be managed? Describe the necessary steps. | The use of idelalisib with other potentially hepatotoxic agents should be avoided whenever possible (e.g., acetaminophen; alcohol; amiodarone; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; cyclosporine (high dosages); disulfiram; endothelin receptor antagonists; interferons; ketolide and macrolide antibiotics; kinase inhibitors; methotrexate; nonsteroidal anti-inflammatory agents; nucleoside reverse transcriptase inhibitors; proteasome inhibitors; retinoids; sulfonamides; tamoxifen; tetracyclines; thiazolidinediones; tolvaptan; vincristine; zileuton; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, lomitapide, mipomersen, niacin, and statins; herbals and nutritional supplements such as black cohosh, chaparral, comfrey, DHEA, kava, pennyroyal oil, and red yeast rice). Patients treated with idelalisib should have serum ALT, AST, and bilirubin measured prior to initiation of treatment and regularly during treatment in accordance with the product labeling, and the dosing adjusted or interrupted as necessary. | 604,365 |
What is the severity level of interaction between Meperidine and Venlafaxine? | Major | 106,530 |