ads_id
stringlengths 8
8
| arxiv_id
int64 0
999
| title
stringlengths 0
236
| abstract
stringlengths 0
4.26k
⌀ | embed
sequencelengths 1.54k
1.54k
| date
date32 | cites
int64 1
1.16k
| bibcode
stringlengths 8
8
| keywords
sequencelengths 0
30
| ads_keywords
sequencelengths 0
14
| read_count
int64 0
0
| doi
stringlengths 13
16.8k
⌀ | authors
sequencelengths 0
66
| aff
sequencelengths 0
66
| cite_bibcodes
sequencelengths 1
1.16k
| ref_bibcodes
sequencelengths 0
0
| umap_x
float32 4.76
33.7
| umap_y
float32 2.73
7.65
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
39844819 | 0 | Advancements and Future Directions of Dual-Target Chimeric Antigen Receptor T-Cell Therapy in Preclinical and Clinical Studies. | In recent years, chimeric antigen receptor T-cell (CAR-T) therapy has made groundbreaking progress in the treatment of various cancer types, particularly hematological malignancies. In the meantime, various preclinical and clinical studies have extensively explored dual-target CAR-T therapies which can be designed to recognize two antigens simultaneously based on the immunophenotype of tumor cells. Compared with single-target CAR-T approach, dual-target CAR-T therapies demonstrate varying degrees of superior antitumor CAR effects, prevent antigen escape and relapse, reduce on-target off-tumor effects, and ensure durable responses in different types of cancer. These advantages highlight the potential future prospects in this field, showing varying degrees of advancement in preclinical and clinical studies. Herein, we aimed to review different dual-target CAR-T studies conducted on a wide range of tumor models, summarizing the selection of target combinations, the efficacy and safety demonstrated in preclinical and clinical settings, the existing limitations, and the potential future directions of this promising therapeutic strategy. | [
0.021476397290825844,
-0.012967296876013279,
0.059178426861763,
0.059794869273900986,
-0.04632120952010155,
-0.00737528782337904,
-0.003563805017620325,
0.04000268131494522,
-0.00974198430776596,
0.004645330365747213,
-0.0049122716300189495,
-0.02718949317932129,
-0.029831387102603912,
0.010105244815349579,
-0.007232184987515211,
-0.0339043065905571,
0.017029209062457085,
0.005140685476362705,
0.05314610153436661,
0.01721634343266487,
-0.010815253481268883,
0.008652202785015106,
0.020749876275658607,
-0.0028813157696276903,
-0.012097673490643501,
-0.03835149481892586,
0.01198759488761425,
0.023468825966119766,
-0.024261394515633583,
0.0033931827638298273,
0.0029996505472809076,
-0.022279974073171616,
-0.029831387102603912,
-0.01196557842195034,
-0.004642578307539225,
0.045022279024124146,
0.032429251819849014,
0.02099204994738102,
-0.03179079294204712,
-0.02058475837111473,
0.05794554203748703,
0.040531057864427567,
0.034740906208753586,
0.08365997672080994,
-0.07432528585195541,
-0.02615475095808506,
-0.010017181746661663,
-0.049403417855501175,
-0.02034258469939232,
0.024239378049969673,
-0.01634671911597252,
-0.01260403636842966,
-0.039144065231084824,
0.042666587978601456,
-0.028862692415714264,
0.017953872680664062,
-0.031174350529909134,
-0.002428616164252162,
0.0164127666503191,
-0.0008758153999224305,
-0.006324034184217453,
-0.019087685272097588,
0.026815224438905716,
-0.015884388238191605,
-0.05257369205355644,
-0.0009432387305423617,
-0.058694079518318176,
-0.02624281495809555,
-0.017524564638733864,
0.030205655843019485,
0.03625999763607979,
-0.002224970143288374,
0.019924284890294075,
0.026947319507598877,
0.05481930077075958,
-0.01471755187958479,
-0.009411747567355633,
0.04352520406246185,
0.030513877049088478,
0.006461632438004017,
0.036986518651247025,
0.0004571715253405273,
0.013132414780557156,
-0.035995807498693466,
-0.013440635986626148,
-0.0321870781481266,
0.029897434636950493,
-0.04088331013917923,
-0.042886748909950256,
-0.006720317993313074,
0.0006793933571316302,
-0.0019332610536366701,
-0.03509315848350525,
0.038307465612888336,
0.024107282981276512,
0.01421118900179863,
-0.021520428359508514,
-0.04306287318468094,
-0.0014324019430205226,
0.038263432681560516,
0.04354722052812576,
0.023138588294386864,
-0.023644952103495598,
0.014695536345243454,
0.0210580974817276,
-0.012394886463880539,
-0.02088197134435177,
-0.0113931680098176,
0.04971164092421532,
-0.020892979577183723,
0.042688604444265366,
-0.010782230645418167,
0.0017970383632928133,
0.06683991849422455,
-0.00970896054059267,
-0.06230466812849045,
-0.014167157001793385,
-0.003076705848798156,
0.010369434021413326,
0.029148899018764496,
-0.03071201965212822,
0.029369056224822998,
0.03969445824623108,
-0.023578904569149017,
0.009505314752459526,
-0.008470572531223297,
0.03976050764322281,
-0.027717871591448784,
-0.015003756619989872,
-0.04317295178771019,
0.007727540098130703,
0.0182510856539011,
0.00802475307136774,
0.0005538345430977643,
-0.03982655331492424,
-0.009257636964321136,
-0.02177361026406288,
-0.02025452069938183,
-0.03784513473510742,
-0.024327442049980164,
0.010209820233285427,
-0.028774630278348923,
0.0024616399314254522,
0.01688610576093197,
-0.0339043065905571,
-0.04467002674937248,
-0.0011111091589555144,
0.03165869787335396,
-0.002307529328390956,
0.0522654727101326,
-0.05037211254239082,
0.03751489520072937,
0.0725640207529068,
-0.014365298673510551,
-0.010028189979493618,
-0.03275948762893677,
-0.027916014194488525,
0.04176394268870354,
-0.041521769016981125,
-0.020529719069600105,
-0.02507597766816616,
0.005531465634703636,
-0.031108302995562553,
-0.018867526203393936,
0.012515973299741745,
-0.012218760326504707,
-0.036788374185562134,
0.02729957178235054,
-0.07727540284395218,
-0.0036105886101722717,
-0.03511517494916916,
-0.03293561190366745,
-0.048390693962574005,
-0.011613326147198677,
-0.019946299493312836,
-0.002782244700938463,
-0.0050085908733308315,
0.003789466805756092,
-0.029258977621793747,
-0.024261394515633583,
0.007903666235506535,
0.008536620065569878,
0.052925944328308105,
-0.006439616903662682,
-0.025648389011621475,
-0.007309240289032459,
-0.008635691367089748,
0.01199860218912363,
-0.03771303966641426,
-0.02390914224088192,
0.017370453104376793,
0.02514202520251274,
0.06908553093671799,
0.021300271153450012,
0.007848626933991909,
-0.033419959247112274,
0.02146538905799389,
0.06058743968605995,
-0.040332917124032974,
-0.03555549308657646,
0.021421357989311218,
-0.018933573737740517,
-0.008404525928199291,
0.012626051902770996,
-0.031020238995552063,
-0.004733393434435129,
-0.016698971390724182,
0.027761904522776604,
-0.031020238995552063,
0.003734427271410823,
0.03608386963605881,
0.013253501616418362,
-0.02857648767530918,
0.03971647471189499,
-0.03430059179663658,
-0.039232127368450165,
-0.034740906208753586,
0.031372491270303726,
0.005110413767397404,
0.009907103143632412,
-0.009230117313563824,
-0.001363602583296597,
-0.01250496506690979,
0.003850010223686695,
-0.03764699026942253,
0.007518390193581581,
-0.007639477029442787,
-0.04552864283323288,
0.012725123204290867,
-0.03617193177342415,
-0.0029418591875582933,
0.0031262412667274475,
0.02500993013381958,
-0.010352922603487968,
-0.03414648026227951,
-0.04403156787157059,
0.0332658514380455,
-0.023733016103506088,
0.05909036472439766,
-0.04348117485642433,
0.005905733909457922,
0.01532298605889082,
0.04083928093314171,
-0.040398962795734406,
-0.011547278612852097,
-0.01535600982606411,
-0.023006495088338852,
-0.07507382333278656,
0.012813186272978783,
-0.004386644810438156,
0.03163668140769005,
0.02833431400358677,
-0.0034124464727938175,
0.01482763048261404,
0.04253449663519859,
0.008019248954951763,
0.05988293141126633,
-0.03777908533811569,
0.00494529539719224,
-0.0040288884192705154,
-0.023116573691368103,
0.0178217776119709,
-0.03727272152900696,
-0.04418567940592766,
-0.06833699345588684,
0.023094557225704193,
-0.004064664244651794,
0.028070123866200447,
0.01701820082962513,
-0.03289158269762993,
0.031328462064266205,
0.01870240829885006,
0.036766357719898224,
-0.03379422798752785,
-0.06455028057098389,
0.020507702603936195,
-0.005927749909460545,
0.0455726720392704,
0.03436663746833801,
0.004039896186441183,
0.0036986516788601875,
0.0197591669857502,
0.023446809500455856,
-0.0388798750936985,
0.005347083788365126,
-0.02240106090903282,
-0.0003128649259451777,
-0.02280835248529911,
-0.001370482612401247,
-0.024591630324721336,
0.018019920215010643,
-0.02274230495095253,
-0.029787356033921242,
-0.04755409434437752,
-0.009197093546390533,
0.008250415325164795,
0.021498413756489754,
-0.009527330286800861,
-0.03659023344516754,
0.022984478622674942,
-0.02604467235505581,
-0.008558636531233788,
-0.012405894696712494,
-0.04361326992511749,
0.053938671946525574,
0.005542473867535591,
-0.0017461269162595272,
-0.005470922216773033,
0.026484988629817963,
0.026551036164164543,
-0.0053388276137411594,
-0.03687644004821777,
0.024745741859078407,
-0.00626899441704154,
-0.0028111403807997704,
0.005938757676631212,
0.02734360471367836,
-0.04764215648174286,
0.004425172694027424,
-0.043921489268541336,
0.0008427917491644621,
-0.0026817976031452417,
-0.0238651093095541,
0.02941308729350567,
0.009164069779217243,
-0.028202218934893608,
0.006043332628905773,
-0.0371406264603138,
0.05561187118291855,
-0.036898452788591385,
0.017953872680664062,
-0.0593985840678215,
0.051693059504032135,
-0.02716747671365738,
-0.027739888057112694,
-0.025626372545957565,
-0.049535512924194336,
-0.030205655843019485,
0.014772591181099415,
-0.003962841350585222,
0.016731996089220047,
0.022169895470142365,
-0.04909519851207733,
0.054070767015218735,
0.017249366268515587,
-0.030227672308683395,
0.011448207311332226,
0.01829511672258377,
-0.008701738901436329,
0.0036573722027242184,
0.016577884554862976,
-0.01924179494380951,
0.033574070781469345,
0.005214988719671965,
-0.006533184088766575,
0.043701332062482834,
-0.03544541075825691,
-0.01879047229886055,
0.014992749318480492,
0.002139659132808447,
0.035687584429979324,
0.0016897114692255855,
-0.04539654776453972,
0.058561984449625015,
0.03377221152186394,
0.05138484016060829,
-0.040575090795755386,
0.02177361026406288,
-0.024327442049980164,
-0.03185683861374855,
-0.0005524585722014308,
0.002390088513493538,
0.00820638332515955,
0.03960639610886574,
-0.03084411285817623,
0.03201095014810562,
0.031042255461215973,
0.0012253159657120705,
0.03286956623196602,
-0.015675237402319908,
0.035753633826971054,
-0.029787356033921242,
-0.05380657687783241,
-0.028092140331864357,
-0.018427211791276932,
0.040553074330091476,
0.04781828448176384,
-0.007133114151656628,
-0.08242709934711456,
0.0038252423983067274,
-0.023270683363080025,
-0.041543785482645035,
0.005861702375113964,
-0.002447880106046796,
-0.026881271973252296,
0.06917359679937363,
-0.042688604444265366,
0.0663115382194519,
0.03187885507941246,
0.0005648424848914146,
-0.004268310032784939,
-0.050812430679798126,
-0.014871662482619286,
-0.010694167576730251,
0.03057992458343506,
-0.006615743041038513,
0.010446489788591862,
0.022379044443368912,
0.04742199927568436,
-0.00565805658698082,
0.012857218272984028,
0.018240077421069145,
0.039144065231084824,
0.01917574740946293,
0.016489822417497635,
0.002925347303971648,
-0.045968957245349884,
0.0596187449991703,
-0.023512857034802437,
0.0019731647334992886,
0.04121354967355728,
-0.041631847620010376,
0.024723725393414497,
-0.019065668806433678,
-0.0004523555689956993,
-0.000028616219424293377,
0.054026734083890915,
0.02291843108832836,
0.00819537602365017,
-0.05274982005357742,
-0.035929758101701736,
0.06217257305979729,
0.033441975712776184,
-0.03209901228547096,
-0.016765018925070763,
0.03630402684211731,
-0.03311173990368843,
0.02375503070652485,
-0.025758467614650726,
0.01872442476451397,
-0.02483380399644375,
-0.014233204536139965,
0.005724103655666113,
-0.03159264847636223,
0.02291843108832836,
0.008498093113303185,
-0.02597862482070923,
0.0548633337020874,
-0.012824194505810738,
-0.03214304521679878,
-0.018515273928642273,
-0.007848626933991909,
-0.008079792372882366,
-0.0005184028996154666,
-0.034608811140060425,
0.004736145492643118,
0.020815923810005188,
-0.05341029167175293,
0.002622630214318633,
0.04006872698664665,
0.05230950191617012,
-0.0477302186191082,
-0.008866856805980206,
-0.048214565962553024,
0.014970732852816582,
0.057241037487983704,
0.037052564322948456,
0.0022456098813563585,
-0.015345001593232155,
-0.03716264292597771,
0.031416524201631546,
-0.004780177026987076,
-0.03546742722392082,
0.0041499752551317215,
-0.02520807273685932,
0.07199161499738693,
0.02732158824801445,
0.017238358035683632,
0.027849966660141945,
0.030998224392533302,
-0.022478114813566208,
-0.0023419291246682405,
-0.017876816913485527,
0.008008241653442383,
0.03623798117041588,
-0.0026529019232839346,
-0.018581321462988853,
0.012681091204285622,
-0.002399720484390855,
0.01645679771900177,
0.0032500801607966423,
-0.005795655306428671,
0.01374885719269514,
-0.008101808838546276,
-0.0043756370432674885,
-0.00795870553702116,
0.017392469570040703,
-0.01472855918109417,
-0.020507702603936195,
0.03258335962891579,
0.0367223285138607,
0.019924284890294075,
0.002047467976808548,
0.024701708927750587,
0.060983721166849136,
0.06490252912044525,
0.010936340317130089,
0.034542765468358994,
0.014574449509382248,
0.04922729358077049,
-0.060763563960790634,
-0.024811789393424988,
0.02032056823372841,
-0.011547278612852097,
-0.03665627911686897,
-0.021267248317599297,
-0.043745361268520355,
-0.020210489630699158,
0.02274230495095253,
-0.007468854542821646,
-0.0014833135064691305,
-0.0021850664634257555,
-0.010908820666372776,
0.017590612173080444,
0.029016803950071335,
-0.015212906524538994,
-0.037052564322948456,
-0.008421037346124649,
-0.03742683306336403,
-0.041411690413951874,
0.023138588294386864,
-0.009395236149430275,
-0.010330907069146633,
0.016060514375567436,
-0.007865139283239841,
-0.02617676742374897,
-0.027938030660152435,
0.04240240156650543,
-0.03559952229261398,
-0.03894592076539993,
0.006246978882700205,
-0.021817641332745552,
0.029170913621783257,
-0.02202679216861725,
-0.005146189592778683,
0.02855447120964527,
0.007969713769853115,
-0.03729473799467087,
0.01578531786799431,
-0.021696554496884346,
0.021872680634260178,
-0.03989259898662567,
0.011910539120435715,
-0.00820638332515955,
0.020826932042837143,
-0.04343714192509651,
-0.03201095014810562,
-0.03764699026942253,
-0.013231486082077026,
-0.018284108489751816,
-0.020210489630699158,
-0.017931856215000153,
0.011294097639620304,
-0.019032645970582962,
-0.008074289187788963,
0.01948396861553192,
-0.00991260726004839,
-0.01526794582605362,
-0.0326053760945797,
0.0003347087185829878,
-0.0032060486264526844,
-0.008167855441570282,
-0.015972452238202095,
-0.037074580788612366,
0.04561670497059822,
0.005168205127120018,
-0.008068785071372986,
0.02269827388226986,
-0.013187455013394356,
0.01829511672258377,
-0.02507597766816616,
-0.019572032615542412,
0.0016112802550196648,
0.03863770142197609,
0.010094236582517624,
0.005718600004911423,
-0.02496589906513691,
-0.024613646790385246,
-0.011602317914366722,
0.0015782564878463745,
0.045924924314022064,
-0.012053641490638256,
0.03194490447640419,
0.029985498636960983,
-0.04094935953617096,
0.012438918463885784,
0.011470223776996136,
0.001513585215434432,
-0.025362182408571243,
-0.01023733988404274,
-0.00005323347795638256,
0.0013519066851586103,
-0.005074638407677412,
-0.06525478512048721,
-0.0382193997502327,
0.015653222799301147,
0.011305104941129684,
-0.012857218272984028,
0.01414514146745205,
0.010815253481268883,
0.040465012192726135,
0.015444072894752026,
-0.036766357719898224,
0.019230786710977554,
0.03229715675115585,
0.020243514329195023,
-0.033508025109767914,
-0.00010354298137826845,
0.020595766603946686,
-0.017810769379138947,
-0.01028137095272541,
-0.003874778049066663,
-0.016555869951844215,
0.006191939115524292,
0.031130319461226463,
-0.03537936508655548,
-0.02161950059235096,
-0.02291843108832836,
0.019880253821611404,
-0.012978305108845234,
-0.002831780118867755,
-0.029941465705633163,
0.004419668577611446,
0.042446430772542953,
-0.017953872680664062,
-0.046233147382736206,
0.024393489584326744,
-0.011305104941129684,
0.0014544177101925015,
-0.0031840328592807055,
-0.02267625741660595,
0.004780177026987076,
-0.01921978034079075,
-0.033463992178440094,
0.01836116425693035,
-0.020760884508490562,
0.003137249266728759,
-0.010011677630245686,
-0.0001507565175415948,
-0.012185736559331417,
-0.012185736559331417,
-0.017403477802872658,
0.03205498307943344,
-0.025648389011621475,
-0.005437898449599743,
-0.004714129958301783,
0.005900230258703232,
-0.002253865823149681,
0.03212102875113487,
0.08555334061384201,
-0.02626482956111431,
0.021201200783252716,
-0.016621917486190796,
-0.011051923967897892,
-0.0019222531700506806,
0.0008544876473024487,
0.02108011394739151,
0.0053030517883598804,
-0.0048269606195390224,
-0.0005858262302353978,
0.06626751273870468,
0.005071886349469423,
0.004482964053750038,
-0.013737848959863186,
-0.013958007097244263,
0.013088383711874485,
0.024789772927761078,
0.007870642468333244,
-0.02500993013381958,
0.026440957561135292,
-0.031350474804639816,
0.008167855441570282,
-0.03496106341481209,
-0.06433012336492538,
0.0012280679075047374,
-0.006125892046838999,
0.014629488810896873,
0.01699618622660637,
0.00877879373729229,
-0.027673840522766113,
-0.0052094850689172745,
-0.018504265695810318,
-0.01859232969582081,
0.0038665221072733402,
0.013242494314908981,
0.013396604917943478,
0.011503247544169426,
-0.010804246179759502,
-0.02280835248529911,
-0.02833431400358677,
0.025780484080314636,
0.014200180768966675,
0.014596465043723583,
-0.015994466841220856,
0.020727861672639847,
-0.002908835420385003,
0.023006495088338852,
-0.009175078012049198,
0.019131716340780258,
0.028774630278348923,
0.021674539893865585,
-0.019638080149888992,
-0.002600614447146654,
-0.03302367776632309,
0.00010999292135238647,
0.009109030477702618,
-0.035731617361307144,
0.04352520406246185,
-0.015499112196266651,
0.007815603166818619,
-0.011877515353262424,
0.021443374454975128,
-0.009692449122667313,
0.014981741085648537,
0.028202218934893608,
0.026484988629817963,
-0.024239378049969673,
0.03978252038359642,
-0.027475697919726372,
-0.00565805658698082,
0.009290660731494427,
-0.03394833952188492,
-0.03419051319360733,
-0.004744401667267084,
-0.017810769379138947,
0.01085378136485815,
-0.007149626035243273,
-0.021883688867092133,
-0.005823174957185984,
-0.002670789835974574,
0.04909519851207733,
-0.021949736401438713,
-0.027805935591459274,
0.003439966356381774,
-0.007039546966552734,
0.03311173990368843,
0.03183482214808464,
0.014684528112411499,
-0.00282902829349041,
-0.020034363493323326,
0.011206034570932388,
0.006213955115526915,
0.0003465765912551433,
-0.023336730897426605,
-0.005542473867535591,
-0.01528996229171753,
-0.006340545602142811,
-0.012295815162360668,
-0.032473281025886536,
0.0013718585250899196,
-0.005603017285466194,
0.004386644810438156,
0.003943577408790588,
0.015058795921504498,
0.0035940767265856266,
0.004048152361065149,
0.02734360471367836,
0.034762922674417496,
-0.03055790811777115,
0.012901249341666698,
-0.004122455604374409,
-0.02844439260661602,
-0.0009363588178530335,
-0.0412575788795948,
-0.02177361026406288,
0.02177361026406288,
-0.001528720953501761,
0.031240398064255714,
-0.0056965840049088,
0.022500131279230118,
0.009940126910805702,
0.0023309211246669292,
0.0005827302811667323,
0.035753633826971054,
0.020771892741322517,
-0.02164151519536972,
0.0003350527258589864,
0.015587175264954567,
-0.018019920215010643,
-0.013803896494209766,
-0.011624334380030632,
0.011866508051753044,
-0.039166081696748734,
0.03971647471189499,
-0.009934622794389725,
0.0397384911775589,
0.02866455167531967,
-0.09035278111696243,
-0.043745361268520355,
-0.0012659075437113643,
-0.03306770697236061,
-0.014959725551307201,
0.012108681723475456,
-0.020672820508480072,
-0.01536701712757349,
-0.006208450999110937,
-0.022379044443368912,
0.006538687739521265,
-0.022279974073171616,
0.014035061933100224,
0.006158915814012289,
-0.011090450920164585,
-0.024613646790385246,
-0.03187885507941246,
-0.04574880003929138,
-0.01528996229171753,
0.02379906177520752,
-0.003888537874445319,
-0.0026914295740425587,
-0.02516404166817665,
0.05671266093850136,
-0.0023199133574962616,
0.0199793241918087,
-0.005402123089879751,
-0.011117970570921898,
-0.040575090795755386,
-0.009197093546390533,
-0.0014502897392958403,
0.008718250319361687,
-0.016269665211439133,
0.0501079261302948,
-0.006142403930425644,
-0.034476716071367264,
0.01596144400537014,
-0.0028978276532143354,
-0.0005576185067184269,
0.021454380825161934,
-0.004986574873328209,
0.019472960382699966,
0.032407235354185104,
-0.006054340861737728,
-0.007744051981717348,
-0.039232127368450165,
-0.033750198781490326,
-0.008432045578956604,
0.016324704512953758,
-0.02507597766816616,
0.02116817608475685,
-0.03278150409460068,
-0.02390914224088192,
-0.0034674860071390867,
0.001960780704393983,
-0.0024616399314254522,
-0.008921896107494831,
0.029985498636960983,
0.008343982510268688,
-0.007408311124891043,
-0.035929758101701736,
0.06754442304372787,
0.033441975712776184,
0.02294044755399227,
0.0010629495372995734,
-0.009461283683776855,
-0.03738280013203621,
0.03529130294919014,
-0.024503568187355995,
0.0030381781980395317,
-0.003338143229484558,
0.024613646790385246,
-0.02382107824087143,
-0.008954919874668121,
0.005107661709189415,
0.016203617677092552,
0.0012026121839880943,
-0.009868575260043144,
-0.002823524409905076,
0.023028509691357613,
-0.0206287894397974,
-0.014101109467446804,
-0.010903317481279373,
0.01062812004238367,
-0.024525582790374756,
-0.006103876046836376,
0.0008427917491644621,
0.006577215623110533,
0.019384898245334625,
-0.0049122716300189495,
-0.020782900974154472,
-0.025516293942928314,
0.005514953751116991,
-0.006109380163252354,
0.007298232521861792,
-0.01257101260125637,
-0.014805614948272705,
-0.004015128593891859,
-0.008740265853703022,
-0.025604356080293655,
0.047025714069604874,
-0.044956229627132416,
0.002947363071143627,
-0.024591630324721336,
-0.0332658514380455,
-0.016445791348814964,
0.06049937382340431,
0.006450624670833349,
0.019406912848353386,
-0.0274316668510437,
0.031394507735967636,
0.00974198430776596,
0.017546579241752625,
-0.021696554496884346,
0.019527999684214592,
0.01699618622660637,
0.025780484080314636,
-0.02972130849957466,
-0.001376674510538578,
-0.002775364788249135,
0.07005422562360764,
0.022511139512062073,
-0.014420338906347752,
-0.017480531707406044,
-0.009048487059772015,
0.011602317914366722,
0.024657677859067917,
0.03295762836933136,
0.0034950056578963995,
0.015378025360405445,
0.02633087709546089,
0.010870293714106083,
0.006202947348356247,
-0.006720317993313074,
0.012945281341671944,
0.05587606132030487,
0.03670031204819679,
0.02740965038537979,
0.025296136736869812,
0.02393115684390068,
-0.0017846544506028295,
-0.007050554733723402,
-0.0028152684681117535,
-0.010672151111066341,
0.05662459507584572,
-0.01755758747458458,
-0.047950379550457,
0.0019621567334979773,
0.007188153453171253,
-0.004989326931536198,
-0.031262412667274475,
0.03795521333813667,
0.04460397735238075,
0.04979970306158066,
-0.003382174763828516,
0.025362182408571243,
0.01982521452009678,
-0.013539707288146019,
-0.006610239390283823,
0.015080812387168407,
-0.047157809138298035,
0.06151210144162178,
-0.005523209925740957,
0.012317831628024578,
0.032517313957214355,
-0.012119689024984837,
0.01482763048261404,
-0.005894726142287254,
0.006527679972350597,
0.02263222634792328,
0.023204635828733444,
-0.035973791033029556,
0.03198893368244171,
0.010622615925967693,
-0.005102158058434725,
0.04246844723820686,
0.014684528112411499,
-0.0066652786917984486,
0.030293719843029976,
0.04328303039073944,
-0.03515920788049698,
-0.014376306906342506,
0.0051984768360853195,
0.0451323576271534,
0.029236961156129837,
-0.01596144400537014,
0.004207766614854336,
-0.03621596470475197,
0.013847928494215012,
-0.00572960777208209,
-0.014739567413926125,
-0.014739567413926125,
0.01085378136485815,
0.033419959247112274,
0.01928582601249218,
-0.006395585369318724,
-0.0019332610536366701,
0.0107437027618289,
-0.01980319805443287,
-0.030359765514731407,
-0.06943777948617935,
0.011189522221684456,
0.021608492359519005,
0.008415533229708672,
-0.02283036895096302,
-0.013330557383596897,
0.017359444871544838,
-0.042864732444286346,
-0.004397653043270111,
0.04874294623732567,
-0.0029638749547302723,
0.04453793168067932,
-0.03978252038359642,
0.015477096661925316,
0.00884484127163887,
0.016313696280121803,
0.003987608943134546,
0.008101808838546276,
-0.016192609444260597,
0.0044004046358168125,
-0.05922245979309082,
-0.03500509634613991,
-0.015025773085653782,
-0.03258335962891579,
0.0023983444552868605,
-0.0008022001129575074,
0.05715297535061836,
0.011624334380030632,
-0.006362561602145433,
0.0019318850245326757,
-0.01917574740946293,
0.02512001059949398,
0.026837240904569626,
0.029258977621793747,
-0.005680072121322155,
0.011040915735065937,
-0.0014227700885385275,
-0.010220827534794807,
0.005823174957185984,
-0.006274498533457518,
0.040332917124032974,
0.017348438501358032,
0.0009384228033013642,
-0.026881271973252296,
-0.01303334441035986,
0.010105244815349579,
0.04229232296347618,
-0.02833431400358677,
0.00008642915054224432,
0.0016332960221916437,
-0.005195725243538618,
0.014486385509371758,
0.02846640907227993,
0.03865971788764,
0.024943882599473,
0.01540004089474678,
0.019968315958976746,
0.010974868200719357,
0.03874778002500534,
0.02388712577521801,
0.009725472889840603,
-0.005784647073596716,
0.010072221048176289,
-0.015642214566469193,
0.021905705332756042,
-0.004824208561331034,
0.008613675832748413,
-0.032473281025886536,
0.018845511600375175,
0.011833484284579754,
-0.006500160321593285,
0.028928739950060844,
-0.01777774654328823,
0.023358747363090515,
0.010716183111071587,
-0.031042255461215973,
0.026925303041934967,
0.0010691415518522263,
0.0032638399861752987,
0.007986226119101048,
0.00021706186817027628,
0.00655519962310791,
-0.01872442476451397,
0.01661090925335884,
0.010919828899204731,
0.018911559134721756,
-0.008982439525425434,
-0.010694167576730251,
0.004323349799960852,
-0.023380761966109276,
-0.013374588452279568,
-0.013781880959868431,
-0.012901249341666698,
-0.011569294147193432,
-0.022125862538814545,
-0.027871983125805855,
0.0024038483388721943,
-0.010380442254245281,
-0.019164739176630974,
-0.016060514375567436,
0.006984507665038109,
0.024261394515633583,
-0.01077672652900219,
-0.030051546171307564,
0.03837351128458977,
0.00967593677341938,
-0.03645813837647438,
-0.05499542877078056,
0.04979970306158066,
-0.01865837723016739,
-0.050680335611104965,
-0.0022263461723923683,
0.009747488424181938,
-0.009268645197153091,
0.02280835248529911,
0.0003009970532730222,
-0.017986895516514778,
-0.0005445466376841068,
0.01836116425693035,
0.024107282981276512,
-0.024217363446950912,
0.015565159730613232,
0.0030161624308675528,
-0.010903317481279373,
-0.023248668760061264,
-0.007050554733723402,
0.01188852358609438,
-0.015223914757370949,
-0.013539707288146019,
-0.04808247089385986,
0.02516404166817665,
-0.024525582790374756,
0.013946998864412308,
0.003112481441348791,
-0.002423112280666828,
-0.0003519085585139692,
0.007028539199382067,
-0.006456128787249327,
-0.010407961905002594,
-0.010440985672175884,
-0.011778444051742554,
0.008052272722125053,
0.0060928682796657085,
0.00282902829349041,
0.021982761099934578,
-0.02399720437824726,
0.0008173359674401581,
-0.019605055451393127,
-0.041675880551338196,
-0.009521826170384884,
0.05239756777882576,
-0.016820058226585388,
-0.030271703377366066,
0.04279868304729462,
0.001751630799844861,
-0.0017750225961208344,
-0.02602265775203705,
0.01628067158162594,
0.015906404703855515,
-0.006505664438009262,
0.018867526203393936,
0.022103847935795784,
0.023490842431783676,
-0.017931856215000153,
-0.010699670761823654,
-0.003943577408790588,
-0.010187803767621517,
0.008299950510263443,
0.019693119451403618,
0.007001019548624754,
0.007512886542826891,
0.015642214566469193,
-0.03176877647638321,
0.02058475837111473,
0.0004836592706851661,
0.010374938137829304,
0.04352520406246185,
0.026418941095471382,
0.024459535256028175,
0.014464369975030422,
-0.007518390193581581,
-0.02516404166817665,
-0.02043064683675766,
-0.014816622249782085,
-0.007925682701170444,
-0.025274120271205902,
-0.039320189505815506,
-0.026727162301540375,
0.008415533229708672,
-0.005000335164368153,
-0.0124719412997365,
-0.026859257370233536,
0.020419640466570854,
-0.012328838929533958,
-0.031020238995552063,
0.007204665336757898,
0.007111098151654005,
0.005195725243538618,
-0.016875099390745163,
0.015256938524544239,
-0.03269343823194504,
-0.015223914757370949,
0.027871983125805855,
-0.007545909844338894,
0.011569294147193432,
0.01874643936753273,
0.008525612764060497,
0.01820705272257328,
0.006252482533454895,
0.0008187119965441525,
-0.004890256095677614,
0.008019248954951763,
-0.05358641967177391,
0.01358373835682869,
-0.006224962882697582,
0.0032308162190020084,
0.005003086756914854,
-0.028026092797517776,
-0.048522789031267166,
0.006698302458971739,
0.006538687739521265,
-0.002950115129351616,
-0.006956987548619509,
-0.008184367790818214,
0.0073422640562057495,
0.01989126019179821,
0.01831713318824768,
0.016082530841231346,
-0.02866455167531967,
0.020782900974154472,
0.005669064354151487,
0.010859285481274128,
-0.0011193649843335152,
-0.005718600004911423,
-0.04301884397864342,
0.006120387930423021,
-0.020793907344341278,
-0.005872710607945919,
-0.03903398662805557,
0.0026749176904559135,
-0.005426890682429075,
-0.004727889783680439,
0.04777425155043602,
0.021762602031230927,
0.008514604531228542,
-0.014475378207862377,
-0.007265208754688501,
-0.006043332628905773,
0.003877529874444008,
0.023402778431773186,
0.028092140331864357,
0.027101431041955948,
-0.03190087154507637,
-0.008828329853713512,
-0.0036105886101722717,
-0.020122427493333817,
-0.044714055955410004,
-0.0010643255664035678,
0.023733016103506088,
0.0105290487408638,
-0.02274230495095253,
-0.016864091157913208,
-0.004441684577614069,
0.011007891967892647,
-0.00025851346435956657,
0.017920847982168198,
-0.039298173040151596,
-0.024261394515633583,
-0.016919130459427834,
-0.008371502161026001,
0.01476158294826746,
0.007854131050407887,
0.019054660573601723,
0.019561024382710457,
0.025604356080293655,
-0.019131716340780258,
0.028114156797528267,
0.014640496112406254,
-0.003321631345897913,
-0.02368898317217827,
-0.023270683363080025,
0.017238358035683632,
0.020210489630699158,
0.0007698644767515361,
0.026749176904559135,
0.03392632305622101,
-0.007936690002679825,
-0.025384198874235153,
0.05503946170210838,
-0.00479944096878171,
0.00823940709233284,
-0.025560325011610985,
-0.009934622794389725,
0.005999301094561815,
-0.014013046398758888,
0.01103541161864996,
0.005938757676631212,
-0.019516993314027786,
0.0029831386636942625,
0.0027038133703172207,
-0.00687442859634757,
-0.0041252076625823975,
0.009197093546390533,
-0.014893678016960621,
0.012207752093672752,
-0.015576167032122612,
-0.05587606132030487,
-0.042600542306900024,
0.02393115684390068,
-0.010149276815354824,
-0.014431346207857132,
-0.00021516988635994494,
-0.027629809454083443,
0.013858935795724392,
0.03256134316325188,
-0.027013367041945457,
0.014926701784133911,
0.030029529705643654,
0.025406215339899063,
-0.00801374576985836,
0.03993663191795349,
0.024503568187355995,
0.007204665336757898,
-0.016842074692249298,
-0.015609190799295902,
-0.019065668806433678,
0.009213605895638466,
0.025494277477264404,
-0.005553481634706259,
0.035797666758298874,
0.03337593004107475,
-0.032385218888521194,
0.0003804602602031082,
0.002680421806871891,
-0.016665948554873466,
0.04583686217665672,
-0.02287440001964569,
-0.018977606669068336,
-0.008437549695372581,
-0.02967727743089199,
-0.010336410254240036,
0.012163721024990082,
0.05367448180913925,
-0.005025102756917477,
0.01253798883408308,
0.02388712577521801,
0.01971513405442238,
-0.008707243017852306,
-0.032451264560222626,
0.014871662482619286,
0.030491860583424568,
-0.008833833038806915,
-0.0030822097323834896,
0.0042352862656116486,
-0.018526282161474228,
-0.019274819642305374,
0.0036408603191375732,
0.007452343124896288,
-0.027717871591448784,
-0.0013374588452279568,
0.01472855918109417,
0.009934622794389725,
0.00017991023196373135,
-0.005845190491527319,
0.01661090925335884,
0.007490870542824268,
-0.003811482572928071,
0.0037014037370681763,
-0.015036780387163162,
0.005192973185330629,
0.009197093546390533,
-0.014508401975035667,
0.004981071222573519,
0.010963860899209976,
-0.010980372317135334,
0.01078773383051157,
-0.010611607693135738,
0.02280835248529911,
-0.009356708265841007,
-0.02291843108832836,
0.003280351869761944,
-0.0052590202540159225,
-0.0046370746567845345,
0.02043064683675766,
-0.010765718296170235,
-0.02379906177520752,
-0.04050904139876366,
-0.004890256095677614,
0.0012315079802647233,
0.030293719843029976,
-0.03637007623910904,
0.00989059079438448,
0.003993113059550524,
0.006863420829176903,
0.01260403636842966,
0.04506630823016167,
-0.004194006789475679,
0.016445791348814964,
-0.017502548173069954,
-0.007909170351922512,
-0.026749176904559135,
0.04506630823016167,
-0.021960744634270668,
-0.028796644881367683,
0.008052272722125053,
-0.02857648767530918,
0.009940126910805702,
-0.024327442049980164,
-0.04308488965034485,
0.006863420829176903,
-0.0321870781481266,
0.0051049101166427135,
-0.00963190570473671,
-0.009780512191355228,
-0.005300300195813179,
0.014739567413926125,
-0.044934216886758804,
0.002523559145629406,
-0.0085861561819911,
0.0013931863941252232,
0.03165869787335396,
0.04654136672616005,
-0.027651824057102203,
-0.007133114151656628,
-0.00938422791659832,
0.03399237245321274,
-0.02218090184032917,
0.0157633014023304,
0.018460234627127647,
0.0016676957020536065,
-0.011150994338095188,
0.04185200482606888,
0.02231299690902233,
-0.02974332496523857,
0.008921896107494831,
-0.026771193370223045,
0.0021437869872897863,
0.012824194505810738,
-0.030227672308683395,
0.015047788619995117,
0.006252482533454895,
0.0250539630651474,
0.0272115096449852,
0.016489822417497635,
-0.025648389011621475,
0.02518605627119541,
-0.02287440001964569,
-0.02835633046925068,
-0.0015782564878463745,
0.006191939115524292,
-0.024195346981287003,
0.005129677709192038,
0.0009748864686116576,
0.005402123089879751,
0.03687644004821777,
0.01080975029617548,
0.000232885722653009,
0.010066716931760311,
-0.021091120317578316,
-0.027563761919736862,
0.005889222025871277,
-0.05024002119898796,
-0.00541037879884243,
0.02139934152364731,
0.021927721798419952,
0.022213926538825035,
0.02941308729350567,
0.009329188615083694,
-0.009109030477702618,
-0.008074289187788963,
-0.03300166130065918,
0.0032253123354166746,
-0.029875418171286583,
-0.0000974370414041914,
0.12179131805896759,
-0.009725472889840603,
-0.008421037346124649,
0.022390052676200867,
0.008685226552188396,
-0.010699670761823654,
0.03733877092599869,
0.014431346207857132,
0.027739888057112694,
-0.0003684203838929534,
0.021157167851924896,
0.026815224438905716,
0.04064113646745682,
0.021355310454964638,
0.0475100614130497,
-0.0018864774610847235,
0.00623597064986825,
0.031460557132959366,
-0.004491219762712717,
0.01203162595629692,
-0.0020928755402565002,
0.009703456424176693,
-0.008299950510263443,
0.02283036895096302,
-0.031240398064255714,
0.010754710994660854,
-0.0028950755950063467,
-0.01479460671544075,
0.019142724573612213,
-0.005751623772084713,
0.004700370132923126,
0.013418620452284813,
-0.004598546773195267,
-0.01818503811955452,
0.015444072894752026,
-0.022015783935785294,
-0.008839337155222893,
-0.010996883735060692,
0.02112414501607418,
0.005883718375116587,
0.007997233420610428,
0.00036670040572062135,
0.0031207373831421137,
-0.0034482222981750965,
0.03718465939164162,
0.004171991255134344,
0.009009960107505322,
-0.0025249351747334003,
0.009885086677968502,
-0.02972130849957466,
0.010545560158789158,
-0.02280835248529911,
0.008283439092338085,
-0.018438220024108887,
-0.035731617361307144,
-0.04216022789478302,
-0.0023474330082535744,
-0.01760161854326725,
-0.0008861353271640837,
-0.012791170738637447,
-0.01652284525334835,
0.029853403568267822,
0.03330988064408302,
-0.007744051981717348,
0.00544340256601572
] | 2025-01-23 | 63 | 39844819 | [
"target combinations",
"target",
"superior antitumor CAR effects",
"various cancer types",
"antigen escape",
"tumor cells",
"varying degrees",
"tumor models",
"different types",
"tumor",
"different dual-target CAR-T studies",
"dual-target CAR-T therapies",
"various preclinical and clinical studies",
"durable responses",
"groundbreaking progress",
"preclinical and clinical studies",
"CAR",
"single-target CAR-T approach",
"preclinical and clinical settings",
"cancer",
"the potential future directions",
"the potential future prospects",
"recent years",
"chimeric antigen receptor T-cell (CAR-T) therapy",
"relapse",
"advancement",
"safety",
"this promising therapeutic strategy",
"two antigens",
"the existing limitations"
] | [
"cancer immunotherapy",
"dual-target CAR-T",
"hematological malignancies",
"solid tumors"
] | 0 | 10.1155/jimr/5845167
10.1073/pnas.90.2.720
10.1038/s41591-019-0564-6
10.1182/blood.2019001641
10.1182/blood-2017-02-769208
10.1038/s41591-019-0549-5
10.1016/j.ajodo.2021.06.028
10.1172/JCI85309
10.1056/NEJMoa1709866
10.1182/bloodadvances.2020003092
10.3389/fimmu.2019.02664
10.1016/j.annonc.2020.10.478
10.1182/blood.2020006245
10.1056/NEJMoa1709919
10.1158/2159-8290.CD-15-1020
10.1182/blood-2015-08-665547
10.1200/JCO.2018.77.8084
10.1172/JCI126397
10.1038/nm.4441
10.1182/blood-2016-04-711903
10.1056/NEJMoa2024850
10.1038/nature12625
10.1158/2159-8290.CD-18-0442
10.1126/scitranslmed.aaa0984
10.1007/s10875-012-9689-9
10.1182/blood.2019003293
10.1182/blood.2019000017
10.1038/s41591-021-01436-0
10.1038/s41375-021-01232-2
10.1038/s41467-021-26683-0
10.1038/s41375-018-0075-3
10.1182/blood-2013-09-529537
10.1200/JCO.2018.77.7250
10.1182/blood-2015-08-661702
10.1172/JCI94306
10.1182/blood.2019002779
10.3389/fonc.2019.01350
10.3389/fonc.2019.00146
10.1186/s13045-019-0758-x
10.3390/cancers12092523
10.1158/2326-6066.CIR-13-0008
10.1126/scitranslmed.3006597
10.1016/j.cell.2018.03.038
10.1158/2326-6066.CIR-20-0675
10.1007/s13577-023-00934-2
10.1186/s13045-020-00856-8
10.1182/bloodadvances.2022008559
10.1158/2159-8290.CD-22-0964
10.1016/j.jcyt.2017.09.005
10.1182/blood.2020005278
10.1182/blood-2018-04-842708
10.1111/j.1365-2141.2010.08297.x
10.1016/j.omto.2023.100751
10.1111/ejh.14104
10.1038/s41392-022-00898-z
10.1016/j.omto.2023.07.007
10.1158/2643-3230.BCD-22-0074
10.1038/s41467-024-47801-8
10.1186/s13046-021-02214-z
10.1186/s13045-021-01170-7
10.3389/fimmu.2022.898341
10.1038/s41467-023-39395-4
10.1038/s41467-020-16160-5
10.1182/blood-2017-05-781351
10.1158/2326-6066.CIR-21-0062
10.1186/s12885-020-07180-x
10.1016/j.jcyt.2020.01.008
10.3389/fonc.2022.954345
10.1002/cam4.3259
10.1016/S2352-3026(19)30115-2
10.1111/cas.14799
10.1016/S1470-2045(18)30864-7
10.1016/S1470-2045(21)00375-2
10.1038/s41408-023-00819-5
10.1002/ajh.25235
10.1182/blood-2012-06-438002
10.1158/2159-8290.CD-19-0945
10.1158/1078-0432.CCR-18-3784
10.1016/j.omto.2018.10.006
10.1007/s12032-011-9955-3
10.1038/sj.onc.1206939
10.1038/s41586-021-03819-2
10.1016/j.jbiotec.2010.07.010
10.1089/104303401753153947
10.1136/jitc-2021-002721
10.1111/cei.12279
10.1007/s00277-008-0535-3
10.12659/MSM.884017
10.1038/s41598-019-46938-7
10.3389/fimmu.2024.1422478
10.21037/tcr-22-174 | [
"Zhang",
"Liu"
] | [
"School of Medicine, University of Tsinghua, Beijing, China.\nDivision of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.",
"Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA."
] | [
"39844819",
"31650176",
"28408462",
"36127190",
"27111235",
"29385370",
"33147337",
"33098993",
"33156925",
"29385376",
"26516065",
"26907630",
"29812997",
"30896447",
"27412889",
"33626253",
"24048066",
"30135176",
"22526592",
"31725148",
"31697824",
"33833386",
"29515236",
"24596416",
"30138085",
"26747249",
"28805662",
"31951650",
"24409448",
"29706540",
"34290048",
"37418233",
"36469024",
"36416874",
"29287970",
"32556247",
"30089630",
"20678160",
"37712633",
"37593111",
"36413381",
"29284597",
"34341066",
"32063474",
"32608579",
"31378662",
"33416209",
"30518502",
"34516954",
"30058145",
"23243285",
"32193224",
"31110075",
"30581986",
"21805377",
"14576843",
"34265844",
"20638430",
"11589831",
"24460857",
"18600325",
"24072209",
"36093513"
] | [] | 8.246161 | 4.160666 |
39844295 | 1 | Application of adoptive cell therapy in malignant melanoma. | Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. Thus, adoptive cell therapy (ACT), employing immune cells with specific tumor-recognizing receptors, has emerged as a promising therapeutic approach to display on-tumor toxicity. This review discusses the application, efficacy, limitations, as well as future prospects of four commonly utilized approaches -including tumor-infiltrating lymphocytes, chimeric antigen receptor (CAR) T cell, engineered T-cell receptor T cells, and chimeric antigen receptor NK cells- in the context of malignant melanoma. | [
-0.0025810925289988518,
0.042373497039079666,
0.051993075758218765,
0.05337037518620491,
-0.00657445564866066,
0.0006899950094521046,
-0.004960432182997465,
0.029482828453183174,
0.007505209185183048,
-0.003752604592591524,
0.02045505680143833,
-0.051993075758218765,
-0.030429722741246223,
0.03027907945215702,
0.02182159759104252,
-0.04002778232097626,
0.047473810613155365,
-0.023306498304009438,
-0.009931623935699463,
0.013977442868053913,
0.04233045503497124,
-0.0010047295363619924,
-0.00586428539827466,
-0.014515451155602932,
-0.0314842164516449,
-0.008010935969650745,
-0.011836172081530094,
0.005003472790122032,
-0.02431795373558998,
-0.005826624576002359,
-0.025953497737646103,
-0.02169247530400753,
-0.015010418370366096,
-0.003892486449331045,
-0.01660292036831379,
-0.0015158370370045304,
0.002486941171810031,
0.018507469445466995,
-0.02078862115740776,
0.001428410760127008,
0.029181543737649918,
-0.005853524897247553,
-0.004497745539993048,
0.10777372866868973,
-0.054704636335372925,
-0.0025864725466817617,
-0.018346065655350685,
-0.0772579237818718,
-0.016280116513371468,
-0.026233261451125145,
0.0073276665061712265,
-0.028944820165634155,
-0.011857692152261734,
0.044676169753074646,
-0.06697121262550354,
0.028040967881679535,
-0.04366471245884895,
-0.020186053588986397,
0.007688131649047136,
0.02810552902519703,
-0.017775777727365494,
0.007446028292179108,
0.021294349804520607,
-0.015881991013884544,
-0.07549325376749039,
-0.02218744158744812,
-0.014838255941867828,
-0.018184663727879524,
-0.024145791307091713,
-0.0006953750853426754,
0.022854572162032127,
-0.04088859260082245,
-0.01362235751003027,
0.0034486299846321344,
0.014515451155602932,
-0.018464427441358566,
0.017797298729419708,
0.004750608932226896,
-0.003069334663450718,
-0.023844506591558456,
0.04687124118208885,
-0.004753299057483673,
0.0074675483629107475,
-0.042265892028808594,
-0.0058051045052707195,
0.005299376789480448,
-0.017937179654836655,
-0.016409238800406456,
-0.06701425462961197,
-0.02539396844804287,
0.010856998153030872,
0.034819867461919785,
-0.02341409958899021,
0.0463547520339489,
-0.005218675825744867,
0.061031606048345566,
-0.05367165803909302,
-0.04988408461213112,
0.030537324026226997,
0.03669213131070137,
0.01594655215740204,
0.014214166440069675,
0.008172338828444481,
-0.0012313653714954853,
0.059180859476327896,
-0.026900390163064003,
-0.04992712661623955,
0.0049550519324839115,
0.026082618162035942,
0.0013920952333137393,
0.04863590747117996,
0.0008668650989420712,
0.0004966484848409891,
0.027825763449072838,
-0.034454021602869034,
-0.040737953037023544,
-0.01249254122376442,
-0.012847626581788063,
0.04626867175102234,
0.0006748635787516832,
-0.013643878512084484,
0.04880806803703308,
0.03989866003394127,
-0.025071164593100548,
0.010539572685956955,
-0.04773205146193504,
0.04799029603600502,
-0.028987860307097435,
-0.042567178606987,
-0.019454361870884895,
0.030924689024686813,
-0.00665515661239624,
0.01968032494187355,
-0.02535092830657959,
-0.07600974291563034,
-0.022402646020054817,
-0.010787056758999825,
0.01204061508178711,
-0.025910455733537674,
0.014580011367797852,
0.004209910985082388,
-0.018421387299895287,
0.004750608932226896,
0.005638321861624718,
-0.02205832116305828,
-0.027287757024168968,
-0.0017256600549444556,
0.05070185661315918,
0.010071506723761559,
0.02698647230863571,
-0.026362383738160133,
0.0470864437520504,
0.03208678588271141,
0.034367937594652176,
-0.020110731944441795,
-0.027287757024168968,
-0.008737246505916119,
0.04811941832304001,
-0.023844506591558456,
-0.08448874950408936,
-0.01688268594443798,
0.010953838936984539,
-0.01841062679886818,
-0.011287404224276543,
-0.011986814439296722,
0.006881120149046183,
-0.041555725038051605,
0.03697189688682556,
-0.03172094002366066,
-0.0022192823234945536,
-0.0229621734470129,
-0.039704978466033936,
-0.04687124118208885,
-0.039210010319948196,
-0.06499134749174118,
-0.025243327021598816,
0.03705797716975212,
0.046440836042165756,
-0.04026450589299202,
-0.0036503830924630165,
-0.023650823161005974,
0.0400923416018486,
0.037488386034965515,
0.04536481946706772,
-0.014052764512598515,
0.017442213371396065,
0.008930929936468601,
-0.0017915660282596946,
-0.0647331029176712,
-0.014074284583330154,
0.018184663727879524,
-0.016172515228390694,
0.015795908868312836,
0.00838216207921505,
-0.003838685806840658,
-0.0011580617865547538,
0.07071574777364731,
0.016301637515425682,
-0.029676511883735657,
-0.02291913330554962,
0.05246652290225029,
-0.048291582614183426,
-0.021477272734045982,
-0.005541480612009764,
-0.016656721010804176,
-0.027847284451127052,
-0.008710346184670925,
0.049281515181064606,
0.03064492531120777,
0.05040057376027107,
0.03378688916563988,
-0.015214861370623112,
-0.0064345733262598515,
0.031613338738679886,
-0.011136761866509914,
-0.0406733900308609,
-0.02083166316151619,
-0.004920081235468388,
0.013503995724022388,
0.03574524074792862,
0.041555725038051605,
-0.013998962938785553,
-0.008699586614966393,
0.016215555369853973,
-0.04080251231789589,
0.0235432218760252,
0.0252218060195446,
-0.03972649574279785,
-0.010797817260026932,
-0.015042698942124844,
-0.023069774731993675,
0.0021493411622941494,
0.01885179430246353,
-0.018991675227880478,
-0.023973628878593445,
-0.0463547520339489,
-0.02436099387705326,
0.006219370290637016,
0.04321278631687164,
-0.018184663727879524,
0.03365777060389519,
-0.0063269720412790775,
0.03316280245780945,
-0.005415048450231552,
-0.017517535015940666,
0.015602226369082928,
-0.01556994579732418,
-0.04017842188477516,
-0.01222353707998991,
-0.0018709221621975303,
-0.01737765222787857,
0.025738293305039406,
-0.008930929936468601,
-0.021520312875509262,
0.016495319083333015,
0.030924689024686813,
0.024016669020056725,
-0.0031069950200617313,
-0.029160022735595703,
0.007623570505529642,
0.00924297422170639,
0.03890872374176979,
-0.038844164460897446,
-0.017237769439816475,
-0.030709486454725266,
0.032560233026742935,
-0.020724061876535416,
-0.008290700614452362,
0.055651526898145676,
0.008129297755658627,
0.020282894372940063,
0.022122880443930626,
0.050314489752054214,
-0.027868805453181267,
-0.03380841016769409,
-0.031247494742274284,
0.007591290399432182,
0.033141281455755234,
-0.008285320363938808,
0.026513025164604187,
0.007521349471062422,
-0.032839998602867126,
0.02276849001646042,
-0.04975496232509613,
-0.027352318167686462,
-0.023392580449581146,
-0.019583484157919884,
-0.0341096967458725,
0.00440628407523036,
-0.028729617595672607,
0.006961821112781763,
-0.022876093164086342,
-0.05040057376027107,
-0.02457619644701481,
-0.01193301286548376,
-0.0034728404134511948,
-0.0005413703620433807,
-0.011276643723249435,
-0.02198299951851368,
0.049238476902246475,
-0.0387796014547348,
0.006402293220162392,
-0.025738293305039406,
-0.05238044261932373,
0.005285926628857851,
0.010216768831014633,
0.003927457146346569,
-0.012427980080246925,
0.01619403436779976,
0.011653249152004719,
0.02476987987756729,
-0.015516145154833794,
0.025609172880649567,
0.03232350945472717,
0.003419039770960808,
0.02954738959670067,
0.03867200016975403,
-0.037445344030857086,
-0.01787262037396431,
-0.015559186227619648,
-0.05720099061727524,
-0.004920081235468388,
-0.03507810831069946,
0.016656721010804176,
0.0033437185920774937,
-0.0463547520339489,
0.0031258254311978817,
-0.02386602573096752,
0.047516848891973495,
-0.06236586719751358,
0.003160795895382762,
-0.037531424313783646,
0.049496717751026154,
-0.02752448059618473,
0.011642488650977612,
0.002435830421745777,
0.005692122504115105,
-0.06503438204526901,
-0.005832004826515913,
-0.0024506256449967623,
0.0008110468043014407,
-0.006940300576388836,
-0.03695037588477135,
0.021595634520053864,
0.013611597940325737,
-0.02978411316871643,
0.0003497050784062594,
0.05009928718209267,
0.01556994579732418,
0.012320378795266151,
0.02629782259464264,
0.012083655223250389,
0.02575981430709362,
-0.0005951711209490895,
-0.0030155337881296873,
0.019648045301437378,
-0.020304415374994278,
-0.03370080888271332,
0.013514756225049496,
0.01742069236934185,
-0.014515451155602932,
-0.0064345733262598515,
-0.02214440144598484,
0.022079840302467346,
0.04192156717181206,
0.05431726947426796,
-0.02892329916357994,
0.011868452653288841,
0.003938217181712389,
-0.042631737887859344,
-0.032517191022634506,
-0.004261021967977285,
0.011265883222222328,
-0.015516145154833794,
-0.06404445320367813,
0.027266236022114754,
0.007892574183642864,
-0.013794519938528538,
0.02616870030760765,
0.022036800161004066,
0.04596738889813423,
-0.021627914160490036,
-0.005751303397119045,
0.010082266293466091,
-0.03787574917078018,
-0.004949671681970358,
-0.002160101430490613,
-0.042136773467063904,
-0.0704144611954689,
0.010243669152259827,
0.017808059230446815,
-0.035766758024692535,
-0.01746373437345028,
-0.001924722921103239,
-0.026771269738674164,
0.023155856877565384,
-0.02058417908847332,
0.0658951997756958,
0.03040820173919201,
0.002412965055555105,
-0.001076015643775463,
-0.043578632175922394,
-0.01581742987036705,
-0.051993075758218765,
-0.00846286304295063,
-0.029590429738163948,
0.014719894155859947,
-0.017969461157917976,
0.03135509416460991,
-0.03456162288784981,
-0.011007639579474926,
-0.0012226228136569262,
0.027632081881165504,
0.035314831882715225,
0.01845366880297661,
-0.034131214022636414,
0.006832699291408062,
0.05883653461933136,
0.003491670824587345,
-0.017119409516453743,
0.01067945547401905,
-0.025135725736618042,
0.015752868726849556,
-0.027137113735079765,
-0.00546615943312645,
0.028170088306069374,
0.07235129177570343,
0.0033571687527000904,
-0.016301637515425682,
-0.034905947744846344,
-0.016129475086927414,
0.07549325376749039,
0.011922253295779228,
-0.014289487153291702,
-0.0038817264139652252,
0.03755294531583786,
-0.027804244309663773,
-0.020982304587960243,
-0.04893719032406807,
0.023930586874485016,
-0.03240958973765373,
-0.07532109320163727,
-0.026814309880137444,
-0.03729470074176788,
0.03660605102777481,
0.03081708773970604,
0.0012125350767746568,
0.027137113735079765,
-0.005256336182355881,
-0.0126109030097723,
0.0317855030298233,
-0.01988476887345314,
-0.005194465629756451,
0.01968032494187355,
0.011179802007973194,
-0.03966193646192551,
0.007376087363809347,
-0.06159113347530365,
0.017603615298867226,
0.02148803137242794,
0.06413052976131439,
-0.029396746307611465,
-0.004850140307098627,
-0.04626867175102234,
-0.019411321729421616,
0.04411664232611656,
0.06227978318929672,
-0.011491847224533558,
0.005409668665379286,
-0.024640757590532303,
0.03385145217180252,
0.007117843255400658,
-0.014838255941867828,
-0.01759285479784012,
-0.004976572468876839,
0.03238806873559952,
0.041555725038051605,
-0.03131205588579178,
-0.018722672015428543,
0.009442036971449852,
-0.01578514836728573,
-0.00840368214994669,
-0.016118714585900307,
-0.026771269738674164,
0.013471716083586216,
0.019938569515943527,
-0.05900869891047478,
0.023973628878593445,
0.0012427980545908213,
0.04099619388580322,
0.006542175076901913,
-0.01331031322479248,
0.03664909303188324,
-0.007031762041151524,
0.004973882343620062,
0.008877129293978214,
0.015666788443922997,
0.0024909761268645525,
-0.01988476887345314,
0.016861164942383766,
-0.033829931169748306,
-0.012363419868052006,
-0.019605005159974098,
0.00003549590473994613,
0.034045133739709854,
0.007838773541152477,
0.022424165159463882,
0.04609651118516922,
0.0008870403980836272,
0.03073100559413433,
-0.04622562974691391,
-0.013460955582559109,
-0.0015763628762215376,
-0.023155856877565384,
-0.05328429490327835,
-0.006897259969264269,
-0.03865048289299011,
0.009060051292181015,
-0.004723708610981703,
0.01807706244289875,
-0.026921911165118217,
-0.01513953972607851,
-0.027825763449072838,
0.0021668265108019114,
0.033507127314805984,
-0.02268240973353386,
-0.04618259146809578,
0.011201323010027409,
-0.05702883005142212,
-0.0212835893034935,
0.011965293437242508,
-0.02498508244752884,
0.02231656387448311,
0.0010336475679650903,
-0.014741414226591587,
-0.021595634520053864,
-0.0451926551759243,
0.018787233158946037,
-0.04035058617591858,
-0.007585910148918629,
0.01906699687242508,
-0.020906982943415642,
0.019368281587958336,
-0.0002664820058271289,
0.0007525384426116943,
0.012320378795266151,
0.006278551183640957,
-0.007849534042179585,
0.018970156088471413,
-0.007779593113809824,
0.019131558015942574,
-0.03393753245472908,
0.006547555327415466,
-0.0007021002238616347,
0.014450890012085438,
-0.0036073424853384495,
-0.011082961224019527,
-0.04366471245884895,
-0.009732561185956001,
-0.0059987870045006275,
-0.01749601401388645,
0.007951755076646805,
0.017237769439816475,
-0.03501354902982712,
0.004688737913966179,
0.016979526728391647,
0.00016636210784781724,
0.0008729177061468363,
-0.0280624870210886,
0.050271451473236084,
-0.024188831448554993,
-0.01215897686779499,
-0.0200461708009243,
-0.02140195108950138,
0.0412544384598732,
-0.014063524082303047,
0.002266357885673642,
-0.0025434319395571947,
0.009759461507201195,
0.024231871590018272,
-0.036993417888879776,
-0.013536276295781136,
-0.03525027260184288,
0.03845679759979248,
0.013772999867796898,
0.005783583968877792,
-0.028858739882707596,
-0.036627572029829025,
0.00029355051810853183,
0.004887801129370928,
0.04867894574999809,
-0.0022300423588603735,
0.015580706298351288,
-0.00735456682741642,
-0.018711911514401436,
0.039296090602874756,
-0.031247494742274284,
-0.01774349808692932,
0.006348492112010717,
0.009576539508998394,
0.0265345461666584,
0.0032307368237525225,
-0.029568908736109734,
-0.03723014146089554,
-0.012955227866768837,
0.051089223474264145,
-0.0008507248712703586,
-0.025566130876541138,
0.0140312435105443,
0.0025178766809403896,
0.04992712661623955,
0.022940652444958687,
-0.027223195880651474,
-0.0018440218409523368,
0.03733774274587631,
0.0026752438861876726,
-0.008274559862911701,
0.0054231188260018826,
0.030881648883223534,
-0.005837384611368179,
-0.014870535582304,
0.006165569648146629,
0.02317737601697445,
0.007908714935183525,
0.0023766495287418365,
-0.06395836919546127,
-0.018496708944439888,
-0.011567167937755585,
0.02358626201748848,
0.01107220072299242,
0.005632941611111164,
-0.016538361087441444,
-0.007031762041151524,
0.05905173718929291,
-0.0035723717883229256,
-0.03873656317591667,
0.0374668650329113,
-0.02251024730503559,
0.027373837307095528,
0.036347806453704834,
-0.021520312875509262,
0.042911503463983536,
0.00200811424292624,
-0.009468937292695045,
0.018722672015428543,
0.005993407219648361,
-0.024188831448554993,
-0.008366021327674389,
0.011642488650977612,
0.016323156654834747,
-0.021703235805034637,
-0.012955227866768837,
-0.01222353707998991,
-0.02991323359310627,
-0.005479609593749046,
0.0004522628150880337,
0.03217286616563797,
-0.0040511987172067165,
0.06240890547633171,
0.049195434898138046,
-0.007209304720163345,
-0.005143354646861553,
0.013278032653033733,
-0.00777421286329627,
-0.030472762882709503,
-0.00998004525899887,
-0.0063269720412790775,
-0.012686224654316902,
0.016463039442896843,
-0.0316348597407341,
0.0658951997756958,
0.02173551544547081,
-0.006784278433769941,
0.01033512968569994,
0.017345372587442398,
0.015925031155347824,
0.0017135548405349255,
-0.013299552723765373,
-0.031699419021606445,
-0.020272133871912956,
-0.01635543815791607,
0.007671991363167763,
-0.020186053588986397,
-0.03669213131070137,
0.019497403874993324,
0.008699586614966393,
0.009931623935699463,
0.006509894505143166,
0.011760850436985493,
-0.03492746874690056,
0.020896224305033684,
-0.015311702154576778,
-0.017614375799894333,
-0.0146876135841012,
-0.010534193366765976,
0.03697189688682556,
0.020734820514917374,
-0.022574808448553085,
-0.023736905306577682,
-0.004710258450359106,
0.03197918459773064,
0.025157244876027107,
0.02883721888065338,
-0.0274814385920763,
0.01918535865843296,
-0.01179313100874424,
-0.035637639462947845,
-0.018303025513887405,
0.008349881507456303,
0.00404850859194994,
-0.01220201700925827,
0.005735163111239672,
-0.02176779694855213,
-0.00019654097559396178,
-0.002351094037294388,
0.000016770713045843877,
-0.004384763538837433,
0.02358626201748848,
-0.007128603756427765,
0.002653723582625389,
0.013934402726590633,
-0.01663520187139511,
-0.014106565155088902,
0.000900490558706224,
0.020885463804006577,
0.028578974306583405,
-0.055694568902254105,
0.04545089974999428,
-0.03187158331274986,
0.009302155114710331,
-0.0316348597407341,
-0.04233045503497124,
-0.016775082796812057,
-0.019917048513889313,
-0.0400923416018486,
0.028901780024170876,
0.0012979438761249185,
-0.04454704746603966,
0.014386328868567944,
0.000754555978346616,
0.026405423879623413,
-0.01766817644238472,
-0.03880112245678902,
-0.021219028159976006,
-0.004295992199331522,
0.030709486454725266,
-0.012643183581531048,
0.006391532719135284,
-0.022703928872942924,
-0.028858739882707596,
-0.01107220072299242,
0.005242886021733284,
0.008172338828444481,
-0.020304415374994278,
-0.02860049530863762,
-0.04583826661109924,
-0.0019610384479165077,
-0.012815346010029316,
-0.0258028544485569,
-0.024188831448554993,
-0.04222285374999046,
0.0005285926745273173,
0.0013329143403097987,
-0.00988320354372263,
0.015666788443922997,
0.0023874095641076565,
-0.013073589652776718,
0.02494204230606556,
-0.01762513630092144,
0.015720589086413383,
0.0010114547330886126,
-0.02444707415997982,
0.02132662944495678,
-0.011879212222993374,
0.011846931651234627,
-0.0003840030694846064,
-0.015257901512086391,
0.0046080369502305984,
-0.008414442650973797,
0.017388412728905678,
0.007564390078186989,
0.0009220109204761684,
0.024511635303497314,
0.010130686685442924,
0.01222353707998991,
0.0012804586440324783,
-0.006418433040380478,
0.04540785774588585,
-0.01956196501851082,
0.0024250701535493135,
-0.01218049693852663,
0.016947245225310326,
-0.01968032494187355,
-0.0035643018782138824,
-0.005853524897247553,
0.010948458686470985,
0.03133357688784599,
-0.0742020383477211,
-0.023887546733021736,
-0.02476987987756729,
-0.002550157019868493,
0.003591202199459076,
-0.01598959229886532,
-0.02074558101594448,
-0.02431795373558998,
0.022983694449067116,
-0.029891714453697205,
0.012234297581017017,
-0.0303221195936203,
0.030149957165122032,
0.011782371439039707,
-0.0038252356462180614,
0.004185700789093971,
-0.021800076588988304,
-0.030924689024686813,
-0.02892329916357994,
0.035142671316862106,
-0.016366196796298027,
0.007489068899303675,
-0.036670614033937454,
0.052983008325099945,
0.007575150113552809,
-0.006396912969648838,
-0.007575150113552809,
-0.01606491394340992,
-0.0361541248857975,
-0.023306498304009438,
-0.025480050593614578,
0.004274472128599882,
-0.041103795170784,
0.03520723059773445,
-0.017388412728905678,
-0.036089565604925156,
0.022079840302467346,
-0.03262479230761528,
-0.020304415374994278,
-0.01626935601234436,
-0.027416877448558807,
0.019056236371397972,
0.03961889445781708,
0.013923642225563526,
-0.012826106511056423,
-0.02888025902211666,
-0.015473105013370514,
-0.008010935969650745,
0.010491152293980122,
-0.023607783019542694,
0.015193340368568897,
-0.05186395347118378,
-0.04293302446603775,
-0.005078793969005346,
-0.0038844163063913584,
-0.04523569718003273,
0.007133983541280031,
0.046440836042165756,
-0.00807549711316824,
0.007203924469649792,
-0.027309276163578033,
0.035357873886823654,
0.038069434463977814,
0.0013645222643390298,
-0.01729157194495201,
-0.027718162164092064,
0.013181191869080067,
0.027696643024683,
0.019002435728907585,
0.019379042088985443,
-0.017732737585902214,
-0.006321591790765524,
-0.04187852889299393,
0.04136203974485397,
0.0004801719624083489,
-0.019056236371397972,
0.003206526627764106,
-0.020035410299897194,
-0.017399173229932785,
0.054876796901226044,
-0.019648045301437378,
-0.0025595722254365683,
0.01758209615945816,
0.00298325321637094,
-0.027395358309149742,
-0.008667306043207645,
0.0011768920812755823,
0.01988476887345314,
0.049367595463991165,
-0.009146132506430149,
0.013697679154574871,
-0.02205832116305828,
-0.009824022650718689,
0.006687437184154987,
-0.01812010258436203,
-0.011244363151490688,
-0.0064668538980185986,
-0.009146132506430149,
-0.011351964436471462,
0.015795908868312836,
0.053843822330236435,
0.017646655440330505,
-0.02535092830657959,
-0.011287404224276543,
-0.014655333012342453,
-0.004201841074973345,
0.00924297422170639,
0.003919386770576239,
-0.009560398757457733,
0.006929540541023016,
0.024339472874999046,
-0.029698031023144722,
0.00998542457818985,
-0.03636932745575905,
0.01470913365483284,
0.012503301724791527,
0.005043823271989822,
0.0042152912355959415,
0.015397783368825912,
-0.013568556867539883,
0.0613759309053421,
0.0029563528951257467,
-0.03240958973765373,
-0.013030549511313438,
-0.004013538360595703,
-0.008204619400203228,
0.019691085442900658,
-0.004070029128342867,
0.0007014276925474405,
0.025910455733537674,
0.03040820173919201,
0.004449324682354927,
0.049281515181064606,
0.00545539939776063,
-0.0074675483629107475,
0.02300521358847618,
0.00399739807471633,
0.03927456960082054,
0.003152725752443075,
0.0109323188662529,
0.008742626756429672,
-0.011018400080502033,
-0.004070029128342867,
-0.00023453778703697026,
0.02472683973610401,
0.005417738575488329,
-0.05504896119236946,
0.0018292266177013516,
0.00439552403986454,
0.0017202800372615457,
0.006827319040894508,
0.02054113894701004,
0.02593197673559189,
0.045666102319955826,
0.019454361870884895,
0.017270050942897797,
0.022381125018000603,
-0.02255328744649887,
-0.021380430087447166,
0.002630858216434717,
-0.03776814788579941,
0.023822985589504242,
-0.029160022735595703,
-0.025372449308633804,
-0.014063524082303047,
-0.026276301592588425,
-0.012761545367538929,
0.03327040374279022,
0.03908088803291321,
0.024640757590532303,
0.0037741248961538076,
-0.02008921094238758,
0.03768206760287285,
-0.024296432733535767,
-0.005509200040251017,
0.02571677416563034,
0.025092683732509613,
0.005420428700745106,
0.004551546182483435,
0.0327969565987587,
-0.01606491394340992,
0.011287404224276543,
0.0096949003636837,
0.03785422816872597,
0.0575883574783802,
-0.05358557775616646,
0.0065206545405089855,
-0.01573134772479534,
-0.03421729803085327,
-0.0046510775573551655,
-0.0005608731298707426,
-0.02000313065946102,
0.026405423879623413,
0.04820549860596657,
0.002940212609246373,
-0.03682125359773636,
-0.03019299916923046,
0.03376537188887596,
-0.004188390914350748,
-0.006811178755015135,
-0.04605346918106079,
0.0316348597407341,
0.08194935321807861,
-0.010577233508229256,
-0.025243327021598816,
0.018346065655350685,
0.01984172873198986,
-0.04297606274485588,
-0.037445344030857086,
0.03733774274587631,
-0.04493441432714462,
0.06572303175926208,
-0.025652213022112846,
0.017646655440330505,
0.021348150447010994,
0.009996185079216957,
0.00701562175527215,
-0.005057273432612419,
-0.04695732146501541,
0.001256248215213418,
-0.03438945859670639,
-0.04945367947220802,
-0.0011708395322784781,
0.0014929716708138585,
-0.00996390450745821,
0.021305110305547714,
0.05427422747015953,
0.009743321686983109,
-0.018518228083848953,
0.018539749085903168,
0.0031742460560053587,
0.036670614033937454,
0.0029778731986880302,
0.02103610523045063,
0.0042502619326114655,
0.02049809694290161,
-0.025092683732509613,
-0.042911503463983536,
0.051046181470155716,
0.0028353012166917324,
0.06395836919546127,
0.04261022061109543,
-0.012600143440067768,
-0.040780991315841675,
-0.008107777684926987,
0.015688307583332062,
0.040608830749988556,
-0.010916178114712238,
-0.014515451155602932,
0.004500435199588537,
-0.015333223156630993,
0.0077957333996891975,
0.033098239451646805,
0.02399514801800251,
0.05896565690636635,
0.011373485438525677,
0.011104481294751167,
0.015580706298351288,
0.009436656720936298,
0.02991323359310627,
0.0006412380607798696,
0.009727180935442448,
-0.008817948400974274,
-0.007402987685054541,
0.02502812258899212,
0.028665056452155113,
0.008263800293207169,
-0.026771269738674164,
0.01067945547401905,
0.01832454651594162,
-0.0117716109380126,
0.011857692152261734,
-0.012309619225561619,
-0.012793825939297676,
0.009581918828189373,
-0.0024708008859306574,
0.0021923817694187164,
-0.02177855558693409,
0.01873343251645565,
0.00623551057651639,
0.014203405939042568,
-0.017474493011832237,
-0.011395005509257317,
-0.0010215423535555601,
0.028406811878085136,
0.036347806453704834,
-0.0252218060195446,
-0.042567178606987,
-0.006552935112267733,
-0.03421729803085327,
-0.0075105889700353146,
0.008688826113939285,
-0.006757378112524748,
-0.012137455865740776,
-0.010625653900206089,
-0.0341096967458725,
-0.010598753578960896,
0.007101702969521284,
-0.002082090126350522,
-0.01513953972607851,
0.010006945580244064,
0.035809800028800964,
-0.025867415592074394,
0.0039893281646072865,
0.029891714453697205,
-0.03768206760287285,
-0.007768832612782717,
-0.03466922417283058,
0.04325582832098007,
0.004099619574844837,
-0.07205000519752502,
0.015042698942124844,
0.03131205588579178,
0.007505209185183048,
-0.002297293394804001,
0.004793649539351463,
-0.012169736437499523,
0.002684659091755748,
0.0029240725561976433,
0.011846931651234627,
0.0212082676589489,
0.018432147800922394,
-0.012137455865740776,
-0.03828463703393936,
-0.025910455733537674,
0.02642694301903248,
-0.005616801790893078,
-0.02761056087911129,
-0.025953497737646103,
-0.011513367295265198,
0.02276849001646042,
0.011642488650977612,
-0.00516756484284997,
0.0006284603732638061,
0.03245263174176216,
-0.003072024555876851,
-0.0007424507639370859,
0.008898649364709854,
-0.010496532544493675,
-0.017452973872423172,
-0.02210136130452156,
-0.009280635043978691,
0.006827319040894508,
0.011448806151747704,
0.006036447826772928,
0.004357863217592239,
-0.012524821795523167,
-0.007376087363809347,
-0.008887888863682747,
-0.014623052440583706,
0.0405227467417717,
0.0010491152061149478,
-0.0451926551759243,
0.038887206465005875,
0.024339472874999046,
0.007150123827159405,
0.02251024730503559,
0.015397783368825912,
-0.019906289875507355,
0.006972581148147583,
-0.00926449429243803,
0.027997925877571106,
0.0549628771841526,
-0.028299210593104362,
0.009910103864967823,
0.001098881009966135,
-0.02042277716100216,
-0.006418433040380478,
0.0023470590822398663,
0.012094415724277496,
0.007881814613938332,
0.03146269544959068,
-0.02231656387448311,
-0.009350575506687164,
0.003760674735531211,
0.02246720716357231,
0.05634017661213875,
0.019777167588472366,
-0.03322736173868179,
0.018055541440844536,
-0.01807706244289875,
0.0009906068444252014,
0.003335648449137807,
-0.009678760543465614,
-0.00625703064724803,
-0.01819542422890663,
-0.0218646377325058,
0.0012427980545908213,
0.00875338725745678,
0.0317855030298233,
0.006429193541407585,
-0.01206213515251875,
0.027589039877057076,
0.016000352799892426,
0.000002674277084224741,
-0.02395210787653923,
-0.021552592515945435,
0.018303025513887405,
-0.015709828585386276,
0.029310666024684906,
-0.04760293290019035,
-0.015333223156630993,
-0.008640405721962452,
-0.0019395181443542242,
0.008656545542180538,
0.03914544731378555,
-0.013762240298092365,
0.013127390295267105,
-0.007236205041408539,
0.009345196187496185,
-0.005003472790122032,
0.004169560503214598,
-0.035680677741765976,
0.024791400879621506,
-0.002065950073301792,
0.006703577470034361,
0.013062830083072186,
-0.03624020516872406,
-0.013751479797065258,
-0.03781118988990784,
0.007246965076774359,
0.007133983541280031,
0.01647379994392395,
-0.006714337505400181,
-0.03238806873559952,
0.01594655215740204,
0.004309442359954119,
-0.005363937932997942,
0.006187089718878269,
-0.008064737543463707,
0.014095804654061794,
-0.016463039442896843,
0.01072249561548233,
-0.0013894052244722843,
-0.01708712801337242,
-0.015010418370366096,
-0.0007834738935343921,
-0.012987508438527584,
-0.04631171375513077,
0.0258028544485569,
0.008161578327417374,
0.034948986023664474,
0.0263839028775692,
-0.008253039792180061,
0.026556065306067467,
-0.03565915673971176,
-0.005907326005399227,
0.006918780505657196,
0.0022434925194829702,
0.03471226245164871,
0.008236899971961975,
0.028665056452155113,
-0.018593549728393555,
0.0080916378647089,
-0.02198299951851368,
0.013159670867025852,
-0.019260680302977562,
0.002458695787936449,
0.005218675825744867,
-0.008247659541666508,
-0.04532177746295929,
-0.01729157194495201,
0.011836172081530094,
-0.03322736173868179,
0.010227528400719166,
0.008516663685441017,
0.009318294934928417,
0.021068386733531952,
-0.02575981430709362,
-0.010157587938010693,
-0.021089905872941017,
0.009598059579730034,
0.012567862868309021,
-0.00332757830619812,
0.004126519896090031,
-0.006208610255271196,
0.046440836042165756,
0.035271793603897095,
-0.006617496255785227,
0.012374179437756538,
-0.05397294461727142,
0.03019299916923046,
-0.00024159913300536573,
-0.0035804419312626123,
-0.02584589459002018,
0.02498508244752884,
-0.011868452653288841,
-0.002090160269290209,
0.037660546600818634,
0.02313433587551117,
-0.005353177897632122,
0.004271782003343105,
-0.01222353707998991,
-0.007978656329214573,
-0.012976748868823051,
0.017194729298353195,
0.010523432865738869,
-0.032517191022634506,
-0.02982715331017971,
-0.005361247807741165,
0.0033948293421417475,
-0.013019789010286331,
-0.004489675164222717,
-0.022574808448553085,
-0.0016126784030348063,
0.0004135935159865767,
-0.041598763316869736,
-0.09537802636623383,
0.0006879774737171829,
-0.003674593288451433,
-0.01631239615380764,
0.009135372936725616,
-0.029396746307611465,
0.03217286616563797,
0.026685187593102455,
-0.004621487110853195,
-0.008269180543720722,
0.04047970846295357,
0.012653944082558155,
-0.01578514836728573,
0.011082961224019527,
0.010033845901489258,
0.031699419021606445,
-0.02593197673559189,
-0.0014405159745365381,
-0.007811873685568571,
-0.008823327720165253,
0.025544611737132072,
-0.022983694449067116,
0.012686224654316902,
0.035723719745874405,
0.006391532719135284,
0.042545657604932785,
-0.01759285479784012,
-0.026061099022626877,
0.024102749302983284,
-0.007257725577801466,
-0.014526210725307465,
-0.018808752298355103,
-0.0011311614653095603,
0.0049012512899935246,
0.01222353707998991,
-0.01039431057870388,
-0.017065607011318207,
-0.012696984224021435,
0.0003236453339923173,
0.011287404224276543,
-0.023758424445986748,
-0.0018225014209747314,
-0.004261021967977285,
0.030300600454211235,
-0.014536971226334572,
0.0074245077557861805,
0.005611421540379524,
-0.009248354472219944,
-0.014935096725821495,
-0.003596582217141986,
0.005573761183768511,
-0.005832004826515913,
0.0632697194814682,
0.013127390295267105,
-0.0140312435105443,
0.01386984158307314,
0.031290534883737564,
0.018152384087443352,
0.009635720402002335,
0.01659216172993183,
0.0034244197886437178,
-0.03077404759824276,
-0.001884372322820127,
-0.037488386034965515,
-0.012438740581274033,
-0.023371059447526932,
-0.004207221325486898,
-0.031118372455239296,
0.008398301899433136,
-0.01963728480041027,
0.007698891684412956,
-0.0068918801844120026,
-0.03815551474690437,
0.01179313100874424,
-0.004589206539094448,
-0.022402646020054817,
0.025781335309147835,
-0.007182404398918152,
-0.012546341866254807,
-0.0007532109157182276,
0.004123829770833254,
-0.0034432499669492245,
0.005751303397119045,
-0.04400904104113579,
-0.0018924424657598138,
0.012998268939554691,
-0.012869146652519703,
0.014612291939556599,
0.011513367295265198,
-0.014354048296809196,
0.0037364643067121506,
-0.02309129573404789,
0.002213902072981,
0.008661925792694092,
0.025329407304525375,
-0.006875739898532629,
-0.032151345163583755,
0.011567167937755585,
-0.006897259969264269,
-0.0031204454135149717,
-0.010587994009256363,
-0.007435267791152,
0.010491152293980122,
0.010437351651489735,
-0.01906699687242508,
-0.007677371613681316,
0.021832356229424477,
-0.0033948293421417475,
0.017151689156889915,
-0.02571677416563034,
0.004043128807097673,
0.0035992723423987627,
-0.024145791307091713,
0.04375079646706581,
0.05078793689608574,
-0.012815346010029316,
0.00041090347804129124,
-0.01074401568621397,
-0.008129297755658627,
-0.024705318734049797,
-0.002575712511315942,
0.037574466317892075,
0.001957003492861986,
-0.02982715331017971,
0.027911845594644547,
0.02074558101594448,
-0.029525868594646454,
-0.02629782259464264,
-0.013783760368824005,
-0.008027076721191406,
-0.00629469146952033,
-0.05974038690328598,
0.0265345461666584,
0.020971544086933136,
0.0007680061389692128,
-0.011577928438782692,
0.0008043216657824814,
-0.06438877433538437,
-0.0032388069666922092,
-0.0024344853591173887,
-0.03624020516872406,
0.008274559862911701,
-0.03266783431172371,
-0.015193340368568897,
-0.006569075398147106,
0.01638771779835224,
0.03372232988476753,
0.03073100559413433,
0.012503301724791527,
-0.00978098250925541,
0.006181709934026003,
-0.018141623586416245,
-0.02453315630555153,
0.014752174727618694,
-0.002980563323944807,
0.001448586001060903,
0.022703928872942924,
-0.00699410168454051,
-0.017894139513373375,
0.014558491297066212,
0.012793825939297676,
-0.0235432218760252,
-0.000017548301912029274,
-0.02982715331017971,
0.02291913330554962,
-0.017657415941357613,
-0.00924297422170639,
0.1088927835226059,
-0.02793336659669876,
0.007650471292436123,
0.02103610523045063,
0.0023416790645569563,
0.011448806151747704,
0.039704978466033936,
-0.022252002730965614,
0.03733774274587631,
-0.002710214350372553,
0.03150573745369911,
0.01667824201285839,
0.011276643723249435,
0.021520312875509262,
0.026728227734565735,
-0.008274559862911701,
0.006181709934026003,
0.016667481511831284,
-0.008860988542437553,
-0.011126001365482807,
0.028277691453695297,
0.024188831448554993,
-0.011567167937755585,
0.03344256430864334,
-0.018292265012860298,
0.009425897151231766,
-0.004382073879241943,
-0.011061440221965313,
0.0042690918780863285,
-0.004468155093491077,
0.02083166316151619,
0.012740025296807289,
0.020928503945469856,
-0.029203064739704132,
-0.006961821112781763,
-0.0038359956815838814,
-0.020562658086419106,
-0.01914231851696968,
0.01717321015894413,
0.0017229700461030006,
-0.007844153791666031,
-0.016785843297839165,
-0.008236899971961975,
-0.010340509936213493,
0.005708262789994478,
0.006025687325745821,
-0.02900938130915165,
0.024705318734049797,
0.02444707415997982,
-0.016452278941869736,
0.006090248469263315,
-0.003104305127635598,
0.004185700789093971,
-0.017366891726851463,
-0.03376537188887596,
-0.016506079584360123,
-0.0004075409087818116,
0.003577752038836479,
0.021434230729937553,
-0.041275959461927414,
-0.020304415374994278,
-0.006101008504629135,
0.029676511883735657,
-0.008963210508227348,
0.010717115364968777
] | 2025-01-23 | 112 | 39844295 | [
"chimeric antigen receptor",
"adoptive cell therapy",
"skin pigment cells",
"immune cells",
"T cell",
"engineered T-cell receptor T cells",
"advanced melanoma",
"malignant melanoma",
"Cutaneous melanoma",
"tumor",
"surgical resection",
"future prospects",
"specific tumor-recognizing receptors",
"NK cells-",
"efficacy",
"limitations",
"tumor-infiltrating lymphocytes",
"chemo/target therapy",
"a promising therapeutic approach",
"CAR",
"ACT",
"Patients",
"metastasis and drug resistance",
"a poor prognosis",
"the most aggressive skin cancers",
"four commonly utilized approaches",
"the application",
"the context",
"This review",
"four"
] | [
"Adoptive Cell Therapy",
"Chimeric Antigen Receptors (CARs)-T cell",
"Malignant Melanoma",
"Natural Killer (NK) Cells",
"T-cell Receptors",
"Tumor-infiltrating Lymphocytes"
] | 0 | 10.1186/s12967-025-06093-2
10.3322/caac.21492
10.3322/caac.21332
10.3322/caac.21352
10.3390/ijms242115881
10.1016/j.critrevonc.2020.103208
10.1016/S0140-6736(21)01206-X
10.1080/21645515.2021.1971015
10.1016/j.clinthera.2015.02.018
10.1056/NEJMoa1504030
10.1056/NEJMoa1910836
10.1186/s13578-023-01073-9
10.1146/annurev-immunol-070621-030155
10.3390/diagnostics11081341
10.1038/nature13121
10.1038/cr.2014.67
10.1016/j.ejca.2016.04.005
10.1016/j.ccr.2012.02.022
10.1016/j.cell.2017.01.017
10.1016/j.ctrv.2016.11.007
10.1016/j.coi.2021.10.004
10.1007/s00428-018-2484-0
10.1159/000019050
10.1016/j.critrevonc.2017.05.001
10.1126/science.3489291
10.1016/S0022-1759(87)80018-2
10.1007/978-3-030-35723-8_4
10.1038/s43018-023-00521-2
10.1038/s41586-023-06199-x
10.1038/onc.2008.271
10.1016/j.retram.2023.103404
10.1371/journal.pone.0013940
10.1038/cgt.2014.81
10.1093/jnci/86.15.1159
10.1126/science.aaa4967
10.3389/fimmu.2021.690499
10.1200/JCO.2008.16.5449
10.1200/JCO.2005.00.240
10.1136/jitc-2020-001743
10.1200/JCO.1999.17.7.2105
10.1111/imm.13194
10.1158/1078-0432.CCR-11-0116
10.1200/JCO.21.00612
10.1056/NEJMoa2210233
10.1158/1078-0432.CCR-10-0041
10.1097/CJI.0b013e31818403d5
10.1371/journal.pone.0004749
10.1158/1078-0432.CCR-14-1934
10.1038/s41551-021-00820-y
10.3390/ijms242115688
10.1002/ajh.25418
10.1016/j.ebiom.2022.103941
10.1073/pnas.91.10.4318
10.1073/pnas.90.2.720
10.1038/nri3405
10.1136/jitc-2021-003354
10.1038/sj.leu.2403302
10.1111/imr.12125
10.1186/s12943-022-01559-z
10.1158/0008-5472.CAN-18-3158
10.1038/s41408-020-00405-z
10.1016/j.omto.2020.03.019
10.1038/s41586-019-0985-x
10.1158/2767-9764.CRC-22-0486
10.1038/s41467-024-45221-2
10.7150/thno.43991
10.1136/jitc-2020-002151
10.3389/fimmu.2022.835762
10.1016/j.cell.2020.03.001
10.1111/imr.12644
10.3390/cells9061485
10.1084/jem.179.3.1005
10.1073/pnas.91.9.3515
10.4049/jimmunol.169.1.575
10.1038/modpathol.3800232
10.1158/0008-5472.CAN-09-0494
10.1126/science.1129003
10.1038/gt.2009.54
10.1080/10409238.2017.1304354
10.1182/blood-2017-05-787598
10.1007/978-1-0716-0290-4_23
10.1016/j.intimp.2022.109055
10.1182/blood-2009-03-211714
10.1006/jsre.2001.6148
10.1002/ijc.2910630313
10.1007/s00403-004-0527-7
10.1200/JCO.2010.32.2537
10.1097/CJI.0b013e3182829903
10.1126/sciadv.adf3700
10.1080/2162402X.2018.1532759
10.1038/s41591-020-01225-1
10.1016/j.ymthe.2020.09.015
10.1016/S2352-3026(20)30277-5
10.1038/s41568-020-00323-z
10.3389/fimmu.2022.795164
10.1038/s41573-019-0052-1
10.3389/fimmu.2018.01869
10.1182/blood-2004-07-2974
10.1126/science.1068440
10.1056/NEJMoa1910607
10.3390/cancers14153839
10.3390/ijms22115899
10.1038/leu.2017.226
10.1182/blood.2020007748
10.1016/j.it.2013.03.002
10.1073/pnas.1012356108
10.1111/j.1365-2567.2008.03027.x
10.1038/s41598-019-40933-8
10.1038/ncomms6639
10.3390/cancers13061363
10.3389/fonc.2019.01529
10.3389/fimmu.2023.1212546 | [
"Hu",
"Xuan",
"Wang",
"Shen",
"Gao",
"Zhou",
"Wei",
"Gu"
] | [
"Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.",
"Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.",
"Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.",
"Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.",
"Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.",
"Department of Medical Oncology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.",
"Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. [email protected].\nCancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China. [email protected].",
"Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China. [email protected].\nCancer Center, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China. [email protected]."
] | [
"39844295",
"30207593",
"26742998",
"27232110",
"37958863",
"33383207",
"34509219",
"34882516",
"25823918",
"26027431",
"31562797",
"37386520",
"35471840",
"34441278",
"24670642",
"24853952",
"27232329",
"22439926",
"28187290",
"27951441",
"34743069",
"30470934",
"9619397",
"28602168",
"3489291",
"3305708",
"29151905",
"32036604",
"36894637",
"37316667",
"18836471",
"37478776",
"21085676",
"25721207",
"8028037",
"25838374",
"34140957",
"18809613",
"15800326",
"33990415",
"10561265",
"32187647",
"21498393",
"33979178",
"36477031",
"20406835",
"18779745",
"19270751",
"25472998",
"35087171",
"37958672",
"30680780",
"35301179",
"7910405",
"8421711",
"23470321",
"34706886",
"14961035",
"24329791",
"35303871",
"30622115",
"33414408",
"32346608",
"30814732",
"37377890",
"38336975",
"32685008",
"34389616",
"35309357",
"32243795",
"29664568",
"32570906",
"8113668",
"8170938",
"12077290",
"15272278",
"33312347",
"19996290",
"16946036",
"19494842",
"28402189",
"29122757",
"32006414",
"35853277",
"19451549",
"11397121",
"7591235",
"15570431",
"21282551",
"23377668",
"36791198",
"30713784",
"33558725",
"32979309",
"33091355",
"33483715",
"35634281",
"31907401",
"30150991",
"15632206",
"11896281",
"32023374",
"35954502",
"34072732",
"28725044",
"32902645",
"23601842",
"21187373",
"19278419",
"30872676",
"32076597",
"37409132"
] | [] | 10.290885 | 4.705851 |
39844281 | 2 | Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma. | Chimeric antigen receptor (CAR) T-cell therapy plays a critical role in the treatment of B-cell hematologic malignancies. The combination of PD-1 inhibitors and CAR-T has shown encouraging results in treating patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). However, there are still cases where treatment is ineffective. This study aimed to investigate the role of IL4I1 in the poor efficacy of CD19 CAR-T combined with PD-1 inhibitors in R/R DLBCL and to explore potential mechanisms. Transcriptomic and metabolomic correlation analyses were performed on tumor tissue from DLBCL patients. We employed an in vitro co-culture system consisting of Pfeiffer cells, CD19 CAR-T and macrophages to investigate the underlying mechanisms. It was found that IL4I1 levels were significantly increased in the tumor tissues of R/R DLBCL patients compared to responders. Correlation analysis revealed a positive association between IL4I1 and tryptophan (Trp)-kynurenic acid (Kyn) related metabolites. In the in vitro co-culture model, the presence of IL4I1 inhibited the cytotoxicity of CAR-T cells. Depletion of IL4I1 disrupted the IDO-AHR-Kyn signaling pathway, thereby enhancing the effectiveness of PD-1 inhibitors in combination with CD19 CAR-T for DLBCL treatment. CAR-T-mediated cytotoxicity was significantly inhibited when IL4I1 was present in the in vitro co-culture model. These findings suggest that IL4I1 may be a contributing factor to poor prognosis in R/R DLBCL patients. IL4I1 expression enhances immunosuppression via the IDO-AHR-Kyn pathway, inhibiting the effectiveness of PD-1 inhibitors combined with CD19 CAR-T. Therefore, suppression of IL4I1 may represent a potential target for combination therapy in DLBCL. | [
0.006582936272025108,
-0.010425412096083164,
0.025771990418434143,
0.05952047184109688,
0.010011427104473114,
-0.0325123593211174,
0.0029110105242580175,
0.017853809520602226,
-0.013947195373475552,
0.003810406429693103,
-0.00629722885787487,
0.011200903914868832,
-0.05317659676074982,
0.007340935990214348,
0.03342195972800255,
-0.038413096219301224,
0.059473827481269836,
-0.001954764826223254,
0.011171749792993069,
0.0635320395231247,
0.011428304016590118,
0.0028614490292966366,
-0.021037409082055092,
0.008425458334386349,
0.001972256926819682,
-0.015113349072635174,
0.015078363940119743,
-0.0047054290771484375,
-0.011451627127826214,
-0.019218208268284798,
0.011177580803632736,
0.002486822195351124,
-0.027404606342315674,
-0.03610410913825035,
-0.027031436562538147,
0.0008622247260063887,
0.04389401525259018,
0.03717697039246559,
-0.03512454032897949,
-0.03748017176985741,
0.03029666654765606,
-0.0009526016074232757,
0.019276516512036324,
0.04799887537956238,
-0.06670397520065308,
-0.007964828051626682,
0.03920608013868332,
-0.0355910025537014,
0.0635320395231247,
-0.027521220967173576,
-0.040045708417892456,
0.01407547201961279,
-0.0179937481880188,
0.031579434871673584,
-0.041071925312280655,
0.05998693406581879,
0.03146281838417053,
-0.006075659301131964,
0.006349705625325441,
0.008233043365180492,
0.02409273013472557,
-0.03150946646928787,
0.04461703076958656,
-0.01082773506641388,
-0.10570015013217926,
-0.03027334436774254,
-0.07953166216611862,
-0.05299001187086105,
0.03568429499864578,
0.0021223993971943855,
0.02043100818991661,
-0.007253474555909634,
0.014052148908376694,
0.008454612456262112,
0.027008114382624626,
0.023381376639008522,
0.021888699382543564,
-0.012127995491027832,
-0.0048686908558011055,
0.0014401995576918125,
0.028920605778694153,
0.02406940795481205,
0.000018038936104858294,
-0.05322324484586716,
-0.014763502404093742,
-0.040092356503009796,
-0.007947335951030254,
-0.0162561796605587,
-0.026541652157902718,
-0.015078363940119743,
-0.011620718985795975,
-0.040488846600055695,
-0.0719749927520752,
0.036967065185308456,
-0.017760517075657845,
-0.026774883270263672,
0.012361226603388786,
-0.03596417233347893,
0.0015203725779429078,
0.04967813566327095,
0.020104484632611275,
0.025328852236270905,
0.01278104167431593,
-0.02023276314139366,
0.023719560354948044,
0.053643058985471725,
-0.04694933816790581,
-0.022226884961128235,
0.016734302043914795,
0.006647074595093727,
0.07883197069168091,
0.006361367180943489,
-0.041025277227163315,
0.03386509791016579,
-0.03554435819387436,
-0.06978262215852737,
-0.04874521493911743,
-0.021865377202630043,
-0.01730571687221527,
0.037923309952020645,
-0.04764902964234352,
0.02882731333374977,
0.019707992672920227,
0.01363233383744955,
-0.010244658216834068,
-0.06600428372621536,
0.08713498711585999,
-0.04911838471889496,
-0.05322324484586716,
-0.07108871638774872,
0.04963149130344391,
-0.0045450832694768906,
0.021328946575522423,
-0.003250652691349387,
-0.04242466390132904,
-0.004002821631729603,
0.0015932571841403842,
0.0040436373092234135,
-0.025795314460992813,
-0.011527426540851593,
0.009125150740146637,
0.028990574181079865,
0.0012893284438177943,
0.0028731105849146843,
-0.03351524844765663,
-0.06423173099756241,
0.01689756289124489,
-0.042657893151044846,
0.010396257974207401,
0.018681777641177177,
-0.026821529492735863,
0.036990389227867126,
0.03335198760032654,
-0.01591799408197403,
-0.0018658455228433013,
-0.024442575871944427,
0.008489597588777542,
0.06856982409954071,
-0.005976536311209202,
-0.043194323778152466,
-0.011824795976281166,
-0.00858288910239935,
-0.0359874963760376,
-0.0036762987729161978,
0.01492676418274641,
0.010168857872486115,
0.015579810366034508,
0.033235374838113785,
-0.06339210271835327,
-0.014425317756831646,
-0.03461143374443054,
-0.03547438979148865,
-0.08354323357343674,
-0.025422144681215286,
-0.06968933343887329,
0.02058260887861252,
0.010407919995486736,
0.004297275561839342,
-0.02612183801829815,
-0.0015961725730448961,
-0.004017398692667484,
0.013165872544050217,
0.04170164838433266,
-0.020909130573272705,
-0.049351613968610764,
0.03195260465145111,
-0.042634569108486176,
0.01960304006934166,
-0.024722453206777573,
0.021807068958878517,
0.03386509791016579,
0.01132918056100607,
0.0532698892056942,
0.021293962374329567,
0.009673242457211018,
0.0024474645033478737,
0.026564976200461388,
0.016827594488859177,
-0.05135739967226982,
0.01571974903345108,
0.0030407451558858156,
0.012932641431689262,
-0.03915943205356598,
-0.002004326321184635,
-0.015031717717647552,
0.019987870007753372,
-0.002848329721018672,
-0.0003416465187910944,
-0.02248343825340271,
0.00846044346690178,
0.024745775386691093,
-0.004058213904500008,
-0.00798232015222311,
0.02619180642068386,
-0.0020436840131878853,
-0.015229963697493076,
-0.004976559896022081,
0.0522436760365963,
0.04244798421859741,
0.00980152003467083,
0.010063904337584972,
-0.020279409363865852,
-0.023637929931282997,
0.010396257974207401,
-0.029596975073218346,
0.021049069240689278,
0.05756133422255516,
-0.033282019197940826,
0.004682105965912342,
-0.02348633110523224,
0.0203610397875309,
0.014180425554513931,
0.01725907064974308,
-0.021620485931634903,
0.006460490170866251,
-0.011929749511182308,
-0.007486705202609301,
0.018658455461263657,
0.07566003501415253,
-0.04167832434177399,
-0.009929796680808067,
0.011620718985795975,
0.01415710337460041,
0.012081350199878216,
-0.0006406555767171085,
-0.006489643827080727,
0.01598796434700489,
-0.07542680203914642,
-0.04338090866804123,
-0.024699131026864052,
-0.005547975189983845,
0.02453586831688881,
-0.02045433223247528,
-0.01750396378338337,
-0.008635366335511208,
0.03141617402434349,
0.058354318141937256,
-0.02050097845494747,
-0.0036121602170169353,
0.005480921361595392,
-0.006063997745513916,
-0.004110691137611866,
-0.018250301480293274,
-0.0427745096385479,
-0.061386317014694214,
0.007410905323922634,
0.010687796398997307,
0.018903346732258797,
-0.02661162242293358,
-0.002791479928418994,
0.012582795694470406,
0.018098700791597366,
0.03552103415131569,
-0.02226186916232109,
-0.030226698145270348,
0.01060616597533226,
0.01989457756280899,
0.04149173945188522,
-0.013713964261114597,
0.03873961791396141,
-0.02411605417728424,
0.002808972029015422,
-0.02165547013282776,
0.0014715398428961635,
-0.011620718985795975,
-0.010915196500718594,
0.025352176278829575,
-0.011247550137341022,
-0.020081162452697754,
-0.032092541456222534,
0.001353466883301735,
-0.0016092917649075389,
-0.0024634990841150284,
-0.013282488100230694,
-0.023428022861480713,
-0.024419253692030907,
0.01598796434700489,
-0.031696051359176636,
-0.0043818214908242226,
0.061899423599243164,
-0.01591799408197403,
0.031696051359176636,
-0.029993467032909393,
-0.023299746215343475,
-0.02768448367714882,
0.006693720817565918,
0.009072673507034779,
-0.045666567981243134,
0.03666386380791664,
0.038902878761291504,
0.03304878994822502,
0.026401713490486145,
0.0044721984304487705,
0.0399290956556797,
-0.005961959715932608,
0.01679261028766632,
0.032139189541339874,
-0.06469819694757462,
0.039579249918460846,
-0.0019518493209034204,
-0.049444906413555145,
-0.03302546590566635,
-0.030693158507347107,
0.009078504517674446,
0.019346484914422035,
-0.021958669647574425,
0.014215410687029362,
-0.014215410687029362,
-0.029690267518162727,
-0.014623564667999744,
0.02556208334863186,
-0.010751934722065926,
0.024186022579669952,
0.004685021471232176,
-0.004926998168230057,
-0.04715924710035324,
-0.06530459225177765,
-0.06329880654811859,
0.02172543853521347,
0.019987870007753372,
-0.0008680555038154125,
0.03283888101577759,
-0.03241906687617302,
0.03852970898151398,
0.008046458475291729,
-0.02453586831688881,
-0.013807256706058979,
0.025282206013798714,
0.007230151444673538,
0.027474574744701385,
0.04151506349444389,
0.0050727673806250095,
0.018740085884928703,
-0.0014401995576918125,
-0.015556487254798412,
0.03255900368094444,
-0.0074517205357551575,
-0.025212237611413002,
0.006833659019321203,
0.01786547154188156,
-0.0014657090650871396,
0.015778055414557457,
-0.02672823704779148,
0.0376434326171875,
0.03311875835061073,
0.05009795352816582,
-0.014297041110694408,
0.00583951361477375,
-0.04657616838812828,
-0.037969958037137985,
-0.01784214749932289,
-0.02170211635529995,
0.0195330698043108,
0.004055298864841461,
-0.00541386753320694,
0.037923309952020645,
0.01645442470908165,
0.0011617803247645497,
0.00957995094358921,
0.042028170078992844,
0.021107377484440804,
0.013877226039767265,
0.018705101683735847,
-0.021352270618081093,
-0.005999859422445297,
-0.0030932219233363867,
0.013958856463432312,
-0.020547624677419662,
-0.05294336751103401,
0.0471125990152359,
0.02721802145242691,
-0.03619740158319473,
0.037853341549634933,
-0.016780948266386986,
-0.015334918163716793,
0.05499579757452011,
-0.018180333077907562,
0.05994028598070145,
0.06259911507368088,
0.03027334436774254,
-0.02301986888051033,
-0.017270732671022415,
-0.022413469851017,
-0.03363186493515968,
0.030086759477853775,
0.0025495029985904694,
0.03241906687617302,
-0.015346579253673553,
-0.0009759246604517102,
-0.03337531164288521,
-0.01960304006934166,
0.009842335246503353,
0.038506388664245605,
-0.030599866062402725,
0.021130699664354324,
-0.030669836327433586,
-0.011043473146855831,
0.01872842386364937,
0.01889168657362461,
0.04142177104949951,
0.03671051189303398,
0.00009793866774998605,
0.027311313897371292,
-0.05457598343491554,
0.02045433223247528,
-0.004052383359521627,
0.051030874252319336,
0.0195330698043108,
0.05639518052339554,
-0.044243860989809036,
-0.026425037533044815,
0.06063998118042946,
0.015066702850162983,
-0.01933482475578785,
-0.012081350199878216,
0.012524488382041454,
-0.030226698145270348,
0.029643621295690536,
-0.032675620168447495,
-0.004594644531607628,
0.008559565991163254,
-0.008961888961493969,
0.014063810929656029,
-0.05005130544304848,
0.022133592516183853,
0.02123565413057804,
0.03988244757056236,
0.009440012276172638,
-0.02165547013282776,
0.010670304298400879,
-0.031043004244565964,
-0.004122352227568626,
-0.011259211227297783,
0.04179494082927704,
-0.024885714054107666,
-0.016804270446300507,
0.021445561200380325,
-0.0699225589632988,
-0.0046966830268502235,
-0.015976302325725555,
0.03367851302027702,
-0.04132847860455513,
0.018611809238791466,
-0.03029666654765606,
-0.055788781493902206,
0.06348539143800735,
0.023451345041394234,
-0.008063951507210732,
-0.001449674484319985,
-0.0266349446028471,
-0.007037736009806395,
-0.022390145808458328,
-0.02775445207953453,
0.02560872957110405,
0.023393038660287857,
0.03540441766381264,
0.017877131700515747,
-0.0036442296113818884,
0.025235559791326523,
0.0061689517460763454,
-0.0165710411965847,
-0.0022667108569294214,
-0.02878066711127758,
-0.03799327835440636,
0.04447709396481514,
0.0535031221807003,
0.014495287090539932,
0.0044984370470047,
-0.027544545009732246,
0.023393038660287857,
-0.0100813964381814,
-0.013037595897912979,
0.04860527440905571,
-0.010361273773014545,
-0.02822091430425644,
0.021107377484440804,
0.026285098865628242,
-0.004168998450040817,
0.024186022579669952,
-0.001747772446833551,
0.0032185835298150778,
0.05289671942591667,
0.033282019197940826,
0.02462916076183319,
0.04760238528251648,
0.07351431250572205,
-0.002931418130174279,
-0.02109571546316147,
-0.024909038096666336,
-0.02201697789132595,
0.008087274618446827,
-0.0016778032295405865,
0.02326476201415062,
-0.012104672379791737,
-0.044756971299648285,
-0.035264480859041214,
-0.0645582526922226,
-0.049911368638277054,
-0.01109595037996769,
0.004973644390702248,
-0.0044197216629981995,
-0.030623190104961395,
-0.030040113255381584,
0.001515999436378479,
0.05424945801496506,
-0.01850685477256775,
-0.02661162242293358,
-0.0022171493619680405,
-0.028360851109027863,
-0.031672727316617966,
0.03134620562195778,
-0.026051867753267288,
-0.004530506208539009,
0.033305343240499496,
-0.02172543853521347,
-0.04921167716383934,
-0.00770827429369092,
-0.0022798299323767424,
-0.015428210608661175,
-0.04594644531607628,
0.047369152307510376,
0.006040675099939108,
0.008104766719043255,
-0.01148661132901907,
0.02216857671737671,
0.004679190926253796,
-0.01148661132901907,
0.0014802860096096992,
0.008477935567498207,
-0.0013396188151091337,
0.035917527973651886,
-0.022086946293711662,
0.01034961175173521,
0.011037642136216164,
-0.004332260228693485,
-0.02502565272152424,
0.007276797667145729,
-0.026844851672649384,
-0.003670467995107174,
-0.018180333077907562,
-0.028454143553972244,
-0.003667552722617984,
-0.003113629762083292,
-0.007515858858823776,
-0.017912117764353752,
0.009084335528314114,
0.002890602918341756,
-0.00247807614505291,
-0.02978355996310711,
0.04860527440905571,
0.0006668940186500549,
0.029107190668582916,
-0.00431476766243577,
-0.030203374102711678,
0.03967253863811493,
-0.0017973340582102537,
-0.00813975092023611,
0.002507230034098029,
0.02507229894399643,
-0.003760844934731722,
-0.008612043224275112,
-0.01492676418274641,
-0.02623845264315605,
0.038926202803850174,
-0.001969341654330492,
0.00862953532487154,
-0.03342195972800255,
-0.02233183942735195,
-0.028034329414367676,
-0.013783933594822884,
0.025305530056357384,
-0.01960304006934166,
0.015428210608661175,
-0.00813975092023611,
-0.01801707036793232,
0.021643808111548424,
0.01645442470908165,
0.00538179837167263,
-0.021888699382543564,
0.035381097346544266,
0.0016078341286629438,
-0.019568055868148804,
-0.02404608391225338,
-0.033188726752996445,
-0.009451673366129398,
0.04925832152366638,
0.022425130009651184,
0.008098935708403587,
-0.021352270618081093,
-0.020815839990973473,
0.02829088270664215,
0.030203374102711678,
0.0008819035720080137,
-0.012641103006899357,
0.005889074876904488,
0.01034961175173521,
-0.017294054850935936,
-0.01640777848660946,
0.027008114382624626,
-0.03671051189303398,
-0.030133405700325966,
0.0026792376302182674,
-0.0001564285485073924,
-0.011923919431865215,
0.002972233574837446,
-0.04799887537956238,
-0.058354318141937256,
0.0030844758730381727,
-0.013993841595947742,
0.0031806835904717445,
-0.005233113653957844,
-0.012909318320453167,
-0.01840190216898918,
0.02243679203093052,
0.005466344300657511,
-0.05476256459951401,
0.03391174226999283,
-0.002884772140532732,
-0.010151365771889687,
-0.00031067055533640087,
-0.004375990945845842,
0.011923919431865215,
-0.00523019814863801,
-0.017049163579940796,
0.03932269290089607,
-0.0025917759630829096,
-0.01191225741058588,
-0.01304925698786974,
0.009212612174451351,
-0.02355629950761795,
-0.004084452521055937,
-0.0409553088247776,
-0.015346579253673553,
0.04641290754079819,
0.018705101683735847,
0.006594597827643156,
-0.0022754569072276354,
0.01076359674334526,
0.055742133408784866,
0.04242466390132904,
-0.019731316715478897,
0.011078457348048687,
-0.016617687419056892,
-0.016955871134996414,
0.006058167200535536,
0.023719560354948044,
-0.0015684764366596937,
-0.006285567302256823,
0.006810336373746395,
0.02504897676408291,
0.08051123470067978,
-0.0032739758025854826,
0.018833378329873085,
-0.023101499304175377,
-0.007125197444111109,
0.01911325566470623,
0.004341006278991699,
-0.005201044492423534,
-0.05061106011271477,
0.006402182392776012,
-0.0014387418050318956,
-0.017830485478043556,
-0.013294149190187454,
-0.07281462103128433,
-0.0047054290771484375,
0.006530459504574537,
0.017154118046164513,
-0.024255990982055664,
-0.009300073608756065,
-0.030739804729819298,
-0.014203748665750027,
-0.018903346732258797,
-0.013247502967715263,
-0.0370137095451355,
-0.005218536593019962,
0.03668718785047531,
0.0060173519887030125,
0.0011829169234260917,
-0.021912023425102234,
-0.01692088693380356,
0.027054760605096817,
0.004361413884907961,
0.021107377484440804,
-0.02094411663711071,
0.025888606905937195,
-0.013597349636256695,
-0.026495005935430527,
-0.026821529492735863,
0.020302731543779373,
0.006547951605170965,
0.027941036969423294,
-0.005580044351518154,
-0.027567867189645767,
-0.017632240429520607,
-0.007819059304893017,
0.039019495248794556,
0.0026296761352568865,
0.03936934098601341,
-0.003565514227375388,
0.01205802708864212,
0.015521502122282982,
-0.0011887477012351155,
0.017737194895744324,
-0.04377739876508713,
0.060873210430145264,
0.026984790340065956,
-0.07281462103128433,
0.041538387537002563,
-0.017142456024885178,
0.006402182392776012,
0.006186443846672773,
-0.0051922984421253204,
0.0043380907736718655,
0.0010947264963760972,
-0.023031530901789665,
0.022891592234373093,
-0.02626177668571472,
-0.008950227871537209,
-0.02824423648416996,
0.016151225194334984,
0.035870879888534546,
-0.03745684772729874,
-0.028640728443861008,
0.019124915823340416,
-0.022180238738656044,
0.00625641318038106,
0.032232481986284256,
-0.009941457770764828,
0.008705335669219494,
-0.021807068958878517,
0.0062505826354026794,
0.007941504940390587,
-0.007405074313282967,
-0.008402135223150253,
0.0007638304959982634,
-0.030063435435295105,
-0.0005050902254879475,
-0.008308843709528446,
-0.022401807829737663,
-0.01955639384686947,
-0.029457036405801773,
0.02817426808178425,
-0.004792890511453152,
-0.025935253128409386,
-0.010040581226348877,
0.00888608954846859,
0.003999906126409769,
0.015311595052480698,
0.03489131107926369,
-0.01278104167431593,
-0.035847555845975876,
-0.013375780545175076,
0.02020943909883499,
-0.01514833327382803,
0.009002705104649067,
0.01837857812643051,
-0.0001542420213809237,
0.018425224348902702,
-0.0122912572696805,
0.005591705907136202,
0.01630282588303089,
-0.005725813563913107,
0.0030553219839930534,
0.005789951886981726,
-0.0073292744345963,
-0.015486517921090126,
0.01385390292853117,
0.006180613301694393,
-0.022891592234373093,
-0.023206453770399094,
-0.025468790903687477,
0.0135740265250206,
-0.028384175151586533,
0.013165872544050217,
0.002944537438452244,
0.03192928060889244,
0.0225300844758749,
-0.09991602599620819,
-0.017690548673272133,
-0.023346392437815666,
-0.004754990804940462,
-0.0027215105947107077,
0.00301450677216053,
-0.010267981328070164,
0.013119226321578026,
-0.019906239584088326,
0.005827852059155703,
0.0005131075158715248,
-0.027591191232204437,
0.00970239657908678,
-0.011317519471049309,
-0.004810383077710867,
-0.008075612597167492,
0.0043818214908242226,
-0.03505457192659378,
0.005183551926165819,
0.034284912049770355,
-0.0043293447233736515,
-0.019451439380645752,
-0.012734395451843739,
0.08326335996389389,
0.008839443325996399,
-0.011853950098156929,
-0.03729358687996864,
-0.0007383209303952754,
-0.03500792756676674,
0.0370137095451355,
0.03400503471493721,
-0.006233090069144964,
-0.042681217193603516,
0.01363233383744955,
-0.028640728443861008,
-0.020302731543779373,
0.02719469927251339,
-0.009171796962618828,
-0.017678886651992798,
-0.00031850565574131906,
-0.01850685477256775,
-0.004291444551199675,
0.0011056592920795083,
0.020046178251504898,
-0.022226884961128235,
-0.009830673225224018,
-0.029573651030659676,
-0.004268121439963579,
0.005031952168792486,
-0.006308889947831631,
-0.0027331721503287554,
-0.0022156916093081236,
-0.003813321702182293,
-0.0035888373386114836,
-0.020839162170886993,
-0.013527380302548409,
0.00366463721729815,
0.035894203931093216,
0.024372607469558716,
0.010442904196679592,
-0.023649591952562332,
0.049864720553159714,
0.008355489932000637,
0.019416455179452896,
0.010693627409636974,
0.004991136956959963,
-0.06647074967622757,
0.011620718985795975,
-0.046342939138412476,
0.0004384008061606437,
-0.0013687725877389312,
0.0008899208623915911,
-0.042611248791217804,
0.04034890979528427,
-0.009095996618270874,
0.012920980341732502,
-0.014798487536609173,
-0.010145534761250019,
-0.01491510309278965,
0.02409273013472557,
-0.011923919431865215,
-0.030203374102711678,
-0.0029649450443685055,
0.008571228012442589,
-0.005247690714895725,
0.005031952168792486,
0.011014319024980068,
0.03673383221030235,
0.01180147286504507,
0.003859967924654484,
-0.007160182110965252,
-0.006652905605733395,
-0.007912350818514824,
0.0023687491193413734,
-0.0044809444807469845,
0.024909038096666336,
-0.03127623721957207,
0.007801566738635302,
-0.0012477842392399907,
-0.01723574846982956,
0.026401713490486145,
-0.05648847296833992,
0.006763690151274204,
-0.005591705907136202,
-0.012676088139414787,
0.004358498379588127,
0.03780669346451759,
-0.006833659019321203,
0.012524488382041454,
-0.008979381993412971,
0.03505457192659378,
-0.010028920136392117,
0.0053351521492004395,
0.019568055868148804,
-0.016559379175305367,
0.011434135027229786,
0.028524113819003105,
-0.03570761904120445,
0.002526179887354374,
-0.0015830532647669315,
0.05238361284136772,
0.007993982173502445,
0.00587741332128644,
-0.009877319447696209,
-0.0028585337568074465,
-0.00002039629725913983,
0.019929561764001846,
0.02380119264125824,
0.01308424212038517,
0.010740273632109165,
-0.0075858281925320625,
-0.0019882917404174805,
0.0026413374580442905,
-0.003921191208064556,
0.0372469425201416,
0.028500789776444435,
0.039975740015506744,
0.041071925312280655,
-0.0093117356300354,
0.018518516793847084,
0.015358241274952888,
0.025935253128409386,
0.0007827805238775909,
-0.007480874191969633,
0.021585499867796898,
0.00850708968937397,
-0.03246571123600006,
0.009795689024031162,
-0.02018611691892147,
0.018145347014069557,
-0.018471870571374893,
0.021538853645324707,
0.021853715181350708,
0.03400503471493721,
0.019719654694199562,
0.007043567020446062,
0.029060544446110725,
-0.023882823064923286,
-0.008711166679859161,
0.0204776544123888,
-0.025002330541610718,
0.0329088494181633,
-0.01875174790620804,
-0.024675806984305382,
0.031626082956790924,
0.01940479315817356,
0.010926857590675354,
-0.019416455179452896,
0.034751374274492264,
0.010390426963567734,
0.012314580380916595,
-0.05546225979924202,
0.05844761058688164,
-0.017270732671022415,
-0.02145722322165966,
0.0015743072144687176,
-0.01647774875164032,
0.025235559791326523,
0.023474669083952904,
0.012477842159569263,
-0.024815745651721954,
0.030506573617458344,
0.011848119087517262,
-0.00015961725148372352,
-0.006425505504012108,
-0.008186397142708302,
0.025305530056357384,
-0.019463101401925087,
0.020302731543779373,
-0.007381751202046871,
0.024186022579669952,
-0.02514226920902729,
0.011492442339658737,
0.022984884679317474,
0.040582139045000076,
-0.009830673225224018,
-0.003381845075637102,
0.038483064621686935,
-0.043684110045433044,
-0.03283888101577759,
-0.01336411852389574,
0.04718256741762161,
0.03365518897771835,
-0.02665826864540577,
-0.021223992109298706,
0.020104484632611275,
0.020734207704663277,
-0.05056441202759743,
0.01109595037996769,
0.04907173663377762,
0.005486751906573772,
0.03566097095608711,
-0.029107190668582916,
0.024979006499052048,
-0.009410858154296875,
0.0019124916289001703,
-0.04132847860455513,
0.010209673084318638,
-0.04188823327422142,
-0.05187050625681877,
-0.017468979582190514,
-0.046296291053295135,
0.025445468723773956,
-0.013993841595947742,
-0.03547438979148865,
0.0009897727286443114,
0.032115865498781204,
0.013958856463432312,
0.002103449311107397,
0.005463428795337677,
-0.01362067274749279,
0.04326429218053818,
0.025795314460992813,
0.011748995631933212,
-0.004352667834609747,
-0.0018454378005117178,
-0.002431429922580719,
-0.0366172194480896,
-0.006075659301131964,
-0.017853809520602226,
0.047299183905124664,
-0.0063555361703038216,
-0.003976583480834961,
-0.027544545009732246,
-0.0146585488691926,
-0.018705101683735847,
0.07957831025123596,
-0.045829832553863525,
-0.021492207422852516,
-0.0138888880610466,
-0.016512732952833176,
-0.0018512685783207417,
0.0177955012768507,
0.03617408126592636,
0.028850635513663292,
-0.011941411532461643,
0.02072254754602909,
0.0046442062593996525,
0.02712472900748253,
-0.014845133759081364,
-0.0034780525602400303,
0.01153325755149126,
-0.009469166398048401,
-0.0322791263461113,
-0.0043293447233736515,
0.003221498802304268,
-0.00813975092023611,
0.01804039441049099,
0.022728331387043,
0.02148054726421833,
0.03652392700314522,
0.016337810084223747,
0.025865282863378525,
-0.0014248937368392944,
0.010063904337584972,
-0.0004205440927762538,
0.015218302607536316,
0.007947335951030254,
0.01694420911371708,
-0.009014366194605827,
-0.006081490311771631,
-0.0050727673806250095,
-0.03570761904120445,
0.018565163016319275,
0.006373028736561537,
0.0018702185479924083,
-0.00030447536846622825,
-0.029690267518162727,
-0.00812808983027935,
-0.01540488749742508,
-0.026448359712958336,
0.021305624395608902,
0.005221452098339796,
0.005405121482908726,
0.00042236619628965855,
-0.031043004244565964,
-0.0032885526306927204,
0.010343780741095543,
0.01308424212038517,
-0.03619740158319473,
-0.009171796962618828,
0.020174454897642136,
-0.0250956229865551,
-0.017585594207048416,
0.010775257833302021,
-0.01464688777923584,
-0.017620578408241272,
-0.018122024834156036,
0.007714105304330587,
-0.021643808111548424,
-0.036967065185308456,
0.01308424212038517,
0.009370042942464352,
-0.023649591952562332,
-0.0018614724976941943,
0.005434275139123201,
-0.01576639525592327,
0.017294054850935936,
0.0066703977063298225,
-0.005862836260348558,
-0.012267934158444405,
0.014413656666874886,
0.016069594770669937,
-0.019474763423204422,
-0.025305530056357384,
-0.020547624677419662,
0.005064021330326796,
0.02257673069834709,
0.010792749933898449,
-0.010746103711426258,
0.0027419182006269693,
-0.01777217909693718,
-0.008693673647940159,
-0.012186303734779358,
-0.00030921288998797536,
0.0016296994872391224,
0.001648649456910789,
0.013200856745243073,
-0.01721242442727089,
-0.0065187979489564896,
-0.0012266476405784488,
0.024279315024614334,
0.02670491486787796,
0.0037346063181757927,
0.029083866626024246,
0.00965575035661459,
-0.010402088984847069,
-0.01126504223793745,
-0.036430634558200836,
0.0006195190362632275,
0.046809401363134384,
-0.027101406827569008,
-0.018471870571374893,
0.017515623942017555,
0.019707992672920227,
-0.010011427104473114,
0.023976115509867668,
-0.016244517639279366,
-0.02518891543149948,
0.01994122378528118,
-0.028524113819003105,
0.027591191232204437,
0.023299746215343475,
0.00942252017557621,
-0.018226979300379753,
0.016384456306695938,
-0.01564977876842022,
0.008180566132068634,
0.033188726752996445,
0.010215504094958305,
0.0115215964615345,
0.006687890272587538,
-0.02556208334863186,
-0.025352176278829575,
0.010781088843941689,
-0.009562457911670208,
0.0198479313403368,
-0.003352691186591983,
0.0060873208567500114,
0.04757906123995781,
0.027987683191895485,
-0.03297881782054901,
0.013760610483586788,
-0.034214943647384644,
-0.01833193190395832,
-0.013212518766522408,
-0.01750396378338337,
-0.01627950184047222,
0.03237241879105568,
-0.020442670211195946,
0.02148054726421833,
-0.017095809802412987,
-0.0033730987925082445,
0.008069781586527824,
-0.02223854698240757,
0.0010036207968369126,
0.006180613301694393,
0.008973550982773304,
-0.005868667270988226,
-0.004542167764157057,
-0.023428022861480713,
-0.022868270054459572,
0.020839162170886993,
-0.011509934440255165,
-0.010151365771889687,
-0.0001034961169352755,
0.01643110252916813,
0.020885808393359184,
-0.005632521118968725,
0.010028920136392117,
-0.031043004244565964,
-0.0146585488691926,
-0.060453396290540695,
0.009696565568447113,
0.008168905042111874,
-0.0035101219546049833,
0.005889074876904488,
-0.00995895080268383,
-0.028337528929114342,
-0.00150871102232486,
0.015579810366034508,
0.006600428372621536,
-0.01598796434700489,
0.013958856463432312,
-0.019323162734508514,
0.011072627268731594,
0.017177440226078033,
0.027847744524478912,
-0.021737100556492805,
0.02092079259455204,
0.011550749652087688,
0.0012310207821428776,
0.03570761904120445,
-0.010104719549417496,
-0.02377786859869957,
-0.006711212918162346,
-0.022133592516183853,
-0.00652462849393487,
-0.02661162242293358,
0.02163214609026909,
-0.00641384394839406,
-0.0019066608510911465,
0.018984979018568993,
0.015661440789699554,
0.004915336612612009,
-0.02172543853521347,
0.008087274618446827,
-0.028034329414367676,
0.026308421045541763,
0.028360851109027863,
-0.0065887668170034885,
0.02377786859869957,
-0.009556627832353115,
-0.006938613019883633,
0.0020859569776803255,
0.008845274336636066,
-0.014285380020737648,
-0.0355910025537014,
0.0012485129991546273,
0.027311313897371292,
-0.01519497949630022,
-0.009253427386283875,
-0.005970705766230822,
0.0060173519887030125,
-0.004110691137611866,
0.010956011712551117,
-0.006058167200535536,
-0.02082750014960766,
-0.02143390104174614,
0.008279689587652683,
0.008751981891691685,
0.01087438128888607,
0.01331747230142355,
0.013410764746367931,
0.045270077884197235,
-0.024442575871944427,
0.032722264528274536,
-0.00523019814863801,
0.014728518202900887,
0.014786825515329838,
-0.03311875835061073,
-0.004822044633328915,
-0.00851875077933073,
0.008413797244429588,
0.020757531747221947,
0.0070027513429522514,
0.010921027511358261,
-0.04167832434177399,
0.05644182860851288,
0.01174316555261612,
-0.009865658357739449,
-0.004037806298583746,
0.0007379564922302961,
-0.022226884961128235,
0.0016763455932959914,
0.007288459222763777,
-0.010687796398997307,
-0.032209157943725586,
0.0007328545325435698,
-0.003580091055482626,
0.00938753504306078,
0.007340935990214348,
-0.003795829601585865,
-0.016116240993142128,
0.0201627928763628,
0.019078269600868225,
-0.01906660944223404,
-0.050984229892492294,
-0.009743211790919304,
0.001513084047473967,
-0.01804039441049099,
0.014448640868067741,
-0.000017651736925472505,
0.0030844758730381727,
0.03624404966831207,
0.00820388924330473,
-0.016932548955082893,
0.02058260887861252,
0.03386509791016579,
0.008781135082244873,
-0.015533164143562317,
0.0475090928375721,
0.01884504035115242,
-0.013142549432814121,
-0.021107377484440804,
-0.006215597968548536,
-0.03153279051184654,
0.04394066333770752,
-0.028104297816753387,
0.018565163016319275,
0.039485957473516464,
-0.023882823064923286,
0.019777962937951088,
-0.01518331840634346,
-0.014460302889347076,
0.06539788842201233,
0.004822044633328915,
-0.02321811579167843,
-0.012442857027053833,
-0.013329134322702885,
-0.04594644531607628,
0.041025277227163315,
0.03934601694345474,
-0.008903581649065018,
0.009410858154296875,
0.04869856685400009,
0.024325961247086525,
-0.028524113819003105,
-0.006641244050115347,
0.0038249832578003407,
0.04722921550273895,
-0.004457621369510889,
0.01669931784272194,
-0.004352667834609747,
-0.0013454495929181576,
-0.03911278769373894,
0.009789858013391495,
-0.014985071495175362,
-0.028080975636839867,
-0.0030932219233363867,
-0.016489408910274506,
0.01514833327382803,
0.003026168094947934,
0.004451790824532509,
-0.014203748665750027,
0.005696659442037344,
-0.03447149693965912,
-0.005483836401253939,
-0.04132847860455513,
-0.0045771524310112,
0.01174316555261612,
-0.019719654694199562,
-0.027544545009732246,
-0.029713589698076248,
0.0031107142567634583,
0.00847210455685854,
0.010518704541027546,
0.027031436562538147,
0.002144264755770564,
-0.02882731333374977,
-0.007679120637476444,
0.0018060801085084677,
-0.022716669365763664,
-0.025818636640906334,
-0.014436979778110981,
-0.018390240147709846,
-0.04170164838433266,
0.020291069522500038,
-0.0007146334392018616,
-0.006238921079784632,
-0.04757906123995781,
-0.006128136534243822,
0.011288365349173546,
-0.028990574181079865,
0.01304925698786974,
0.038879554718732834,
0.0036121602170169353,
-0.0059269750490784645,
-0.026564976200461388,
0.026028545573353767,
-0.01828528568148613,
-0.01645442470908165,
0.006612089928239584,
-0.011504103429615498,
-0.0019343569874763489,
-0.009212612174451351,
-0.022786637768149376,
-0.009370042942464352,
-0.03398171067237854,
0.018028732389211655,
-0.01006973534822464,
0.011684857308864594,
-0.004507183097302914,
0.013690641149878502,
0.022203560918569565,
0.005037782713770866,
-0.020244423300027847,
-0.018425224348902702,
0.002244845498353243,
0.025935253128409386,
0.021223992109298706,
0.04746244475245476,
-0.01669931784272194,
-0.017375687137246132,
0.020979100838303566,
0.03253567963838577,
-0.002569910604506731,
0.0063030594028532505,
0.03451814129948616,
-0.0113641656935215,
-0.007008582353591919,
0.02406940795481205,
0.008594551123678684,
-0.008005643263459206,
-0.01750396378338337,
-0.0201627928763628,
-0.01620953343808651,
-0.0009329227614216506,
-0.029923496767878532,
0.003617990994825959,
-0.009527473710477352,
0.007550843525677919,
0.012746057473123074,
0.009853996336460114,
-0.010378765873610973,
0.031229589134454727,
0.00469376752153039,
-0.007550843525677919,
0.012746057473123074,
-0.01926485449075699,
0.0008337997132912278,
0.02109571546316147,
0.013795595616102219,
0.024955684319138527,
0.004265206400305033,
0.010646981187164783,
0.00595029816031456,
0.01564977876842022,
-0.031556110829114914,
-0.018949992954730988,
0.018716763705015182,
0.00297514908015728,
0.012232949957251549,
0.027078082785010338,
0.02172543853521347,
0.011620718985795975,
0.028337528929114342,
-0.004670444410294294,
0.0030961374286562204,
-0.014168764464557171,
-0.04823210835456848,
-0.004317683167755604,
-0.028384175151586533,
0.0009584323852322996,
0.11586900800466537,
-0.014763502404093742,
0.0030757298227399588,
0.022670023143291473,
-0.015090025961399078,
0.0019824609626084566,
0.008133919909596443,
-0.018157009035348892,
0.0009999765316024423,
-0.05252355337142944,
0.01906660944223404,
0.02817426808178425,
0.025002330541610718,
0.015264948830008507,
0.01488011796027422,
-0.012256273068487644,
-0.02658829838037491,
0.03234909847378731,
-0.008722827769815922,
-0.015101687051355839,
-0.016629347577691078,
0.004224390722811222,
-0.05611530318856239,
0.001395739964209497,
-0.01989457756280899,
-0.016594363376498222,
-0.0032856373582035303,
0.0034926296211779118,
-0.00834965892136097,
-0.02275165356695652,
0.01309590321034193,
0.012337903492152691,
-0.005069852340966463,
-0.032652296125888824,
-0.03309543430805206,
0.008303012698888779,
-0.02558540739119053,
-0.007031905464828014,
0.010588672943413258,
0.042681217193603516,
0.03360854089260101,
0.008122258819639683,
0.0048482827842235565,
0.015159995295107365,
0.019369808956980705,
0.005947382654994726,
-0.007632474415004253,
0.0025392991956323385,
0.029480358585715294,
0.00036897824611514807,
-0.0174806397408247,
-0.004352667834609747,
0.04487358406186104,
0.0015976302092894912,
-0.024885714054107666,
-0.034308236092329025,
0.013154210522770882,
0.015848025679588318,
-0.004912421572953463,
-0.03405167907476425,
-0.01755061000585556,
0.004996967501938343,
-0.01616288721561432,
0.0072709666565060616,
0.035334449261426926
] | 2025-01-23 | 20 | 39844281 | [
"IL4I1 levels",
"IL4I1",
"DLBCL patients",
"R/R DLBCL patients",
"DLBCL treatment",
"Pfeiffer cells",
"R/R DLBCL",
"tumor tissue",
"combination therapy",
"Correlation analysis",
"CD19 CAR-T",
"Kyn",
"CD19 CAR-T. Therefore",
"poor prognosis",
"CAR-T cells",
"potential mechanisms",
"patients",
"treatment",
"CAR) T-cell therapy",
"IDO",
"combination",
"large B-cell lymphoma",
"Chimeric antigen receptor",
"B-cell hematologic malignancies",
"CAR-T-mediated cytotoxicity",
"relapsed/refractory (R/R",
"IL4I1 expression",
"Transcriptomic and metabolomic correlation analyses",
"CAR-T",
"immunosuppression"
] | [
"CD19 CAR-T",
"DLBCL",
"IL4I1",
"Metabolism",
"PD-1 inhibitor"
] | 0 | 10.1186/s12967-024-06028-3
10.1056/NEJMoa011795
10.1016/j.blre.2023.101140
10.1056/NEJMoa1804980
10.1158/2643-3230.BCD-23-0056
10.1182/bloodadvances.2020003844
10.1136/jitc-2020-001466
10.1182/blood-2016-09-738245
10.1016/j.cell.2018.09.007
10.1158/1078-0432.CCR-20-1457
10.1016/j.tranon.2021.101085
10.3389/fonc.2019.00767
10.3389/fimmu.2022.994731
10.1182/blood-2023-173202
10.1186/s12967-021-03123-7
10.1016/j.cell.2020.07.038
10.1016/j.immuni.2016.01.018
10.1002/stem.2288
10.1016/j.immuni.2022.05.013
10.1038/s41586-022-05140-y
10.3389/fonc.2021.664421
10.1182/blood-2015-11-679134
10.3390/ijms19020340
10.1182/blood.2021012634
10.3390/cancers11040462
10.1016/j.cell.2018.09.007
10.7554/eLife.82934
10.1038/s41598-019-39553-z
10.1007/s12672-024-01000-5
10.1038/s41586-021-03442-1
10.1016/j.immuni.2017.12.012
10.1038/s41392-020-0188-9
10.1016/j.bcp.2020.113926
10.1158/1078-0432.CCR-19-3874 | [
"Zhang",
"Zhang",
"Xiao",
"Liu",
"Zhao"
] | [
"Department of Hematology, Tianjin First Central Hospital, Tianjin, China.",
"Department of Hematology, First Center Clinic College of Tianjin Medical University, Tianjin, China.",
"Boyalife wsn ltd, Shen Zhen, China.",
"Boyalife wsn ltd, Shen Zhen, China. [email protected].",
"Department of Hematology, Tianjin First Central Hospital, Tianjin, China. [email protected].\nDepartment of Hematology, First Center Clinic College of Tianjin Medical University, Tianjin, China. [email protected]."
] | [
"39844281",
"11807147",
"30501490",
"33414262",
"28031179",
"30290143",
"33028589",
"31482064",
"36275688",
"32818467",
"26885856",
"26850336",
"35704993",
"36045296",
"34113569",
"26813675",
"30290143",
"36779699",
"33828302",
"32217098"
] | [] | 7.412257 | 5.586925 |
39843688 | 3 | Evolving Immunotherapy Strategies in Gastrointestinal Neuroendocrine Neoplasms. | Treatment for neuroendocrine neoplasms (NENs) is tailored to the tumor's site of origin, grade, and differentiation. NENs are categorized into two main types: well-differentiated neuroendocrine tumors (NETs), which tend to grow more slowly and are less aggressive, and poorly differentiated neuroendocrine carcinomas (NECs), which are highly aggressive and harder to treat. Treatment options for NETs range from somatostatin analogues and mTOR inhibitors to peptide receptor radionuclide therapy (PRRT) with Lutetium-177 dotatate. In cases where the disease progresses more rapidly, cytotoxic chemotherapy may also be considered. In contrast, chemotherapy plays a central role in treating NECs, often following protocols similar to those used for small cell lung cancer. Exciting progress is being made in the development of new therapies for NENs. Inspired by the success of immunotherapy in other cancers, clinical trials have begun to explore its potential in NENs. Early findings suggest that immune checkpoint inhibitors (ICIs) may offer benefits, especially in patients with higher-grade NETs and NECs. However, because NENs have an immunologically "cold" tumor microenvironment-meaning they are less likely to trigger an immune response-new strategies are needed to boost ICI efficacy. To overcome this challenge, researchers are exploring innovative approaches, such as combining dual ICIs or pairing ICIs with other therapeutic agents to make the tumors more responsive to immune attack. Moreover, there is growing enthusiasm for cutting-edge therapies designed to enhance the immune system's ability to recognize and destroy cancer cells. These include bispecific T cell engagers, chimeric antigen receptor T cells, tumor-infiltrating lymphocytes, oncolytic viruses, and cancer vaccines. While their effectiveness in NENs is still being studied, these approaches hold considerable promise, offering new hope for patients with this challenging and complex cancer type. | [
-0.005444354843348265,
-0.00921536237001419,
0.05976240336894989,
0.04035157337784767,
-0.002009510761126876,
0.02543487958610058,
0.029546532779932022,
0.03540324792265892,
0.003908460959792137,
0.024024486541748047,
0.01702033169567585,
-0.021442750468850136,
-0.00969346147030592,
0.011958456598222256,
0.004374607931822538,
-0.046973250806331635,
0.02691698633134365,
-0.0029029587749391794,
0.013900735415518284,
0.04981793835759163,
0.04914860054850578,
0.023761531338095665,
0.034542668610811234,
-0.03638334944844246,
-0.01032694336026907,
0.03523591160774231,
-0.026080312207341194,
0.04154682159423828,
0.011922599747776985,
0.00828904565423727,
0.02579345367848873,
0.005088768433779478,
-0.05211281403899193,
0.002746082376688719,
-0.018610011786222458,
-0.0006532777915708721,
0.05373835191130638,
-0.013087966479361057,
0.013554112985730171,
0.00704001123085618,
0.015837036073207855,
-0.019685735926032066,
-0.03882165625691414,
0.06387405842542648,
-0.05340368300676346,
-0.039873477071523666,
-0.0013334485702216625,
-0.0653083547949791,
0.050821948796510696,
-0.0459931455552578,
-0.0030045548919588327,
0.02236309088766575,
-0.01887296698987484,
0.05976240336894989,
-0.041977111250162125,
0.01894468255341053,
-0.03623992204666138,
0.006860723719000816,
-0.007326870691031218,
0.013482398353517056,
0.006992201320827007,
-0.04348312318325043,
0.03929975628852844,
0.03908461332321167,
-0.01936301961541176,
-0.016303183510899544,
-0.028303474187850952,
-0.04977012798190117,
-0.017976531758904457,
-0.03525981679558754,
0.021227605640888214,
-0.009012170135974884,
0.0027610231190919876,
0.012358864769339561,
0.04587361961603165,
0.019147874787449837,
-0.006502149626612663,
0.01464178878813982,
0.005531010217964649,
-0.028422998264431953,
0.005752131342887878,
-0.011271188966929913,
0.004296917002648115,
0.01155804842710495,
0.008318926207721233,
-0.014462501741945744,
-0.026630127802491188,
-0.045706287026405334,
-0.08419327437877655,
-0.01599241979420185,
-0.01751038432121277,
0.02816004492342472,
-0.03932366147637367,
0.06683827191591263,
-0.024813350290060043,
0.019207635894417763,
0.020713649690151215,
-0.036000870168209076,
0.04534771293401718,
0.0355466790497303,
-0.0022112089209258556,
0.024299392476677895,
-0.022446759045124054,
-0.012030172161757946,
0.044319797307252884,
0.015323080122470856,
-0.02677355706691742,
0.0003103909839410335,
0.041953206062316895,
-0.01957816258072853,
0.0293313879519701,
-0.012334960512816906,
-0.0011250271927565336,
0.000593515345826745,
-0.0061136940494179726,
-0.0436982698738575,
-0.019590115174651146,
-0.00860578566789627,
0.0071416073478758335,
0.06420872360467911,
-0.03444704785943031,
0.028925003483891487,
0.028279569000005722,
-0.017976531758904457,
0.0007328364881686866,
-0.039849571883678436,
0.03939537703990936,
-0.011552072130143642,
0.025291448459029198,
-0.02358224429190159,
0.017127905040979385,
-0.003152466844767332,
-0.01748647913336754,
-0.013876830227673054,
-0.09810595959424973,
-0.01774943433701992,
-0.03272589296102524,
-0.022733617573976517,
-0.02808832935988903,
0.010398657992482185,
-0.0029657091945409775,
0.00614955136552453,
-0.013159681111574173,
-0.012645724229514599,
-0.0650693029165268,
-0.04240740090608597,
-0.028279569000005722,
0.020378978922963142,
0.020151881501078606,
0.04668638855218887,
-0.04388950765132904,
0.03310837224125862,
0.021657895296812057,
0.00017797990585677326,
-0.02058217115700245,
0.002726659644395113,
-0.01229910273104906,
0.032295603305101395,
-0.007787041366100311,
-0.07883856445550919,
0.006370672024786472,
0.023785436525940895,
0.004975220188498497,
-0.006191384978592396,
0.048311926424503326,
0.01584898866713047,
-0.03741126507520676,
-0.010207418352365494,
-0.03260636702179909,
0.05574636906385422,
0.012920632027089596,
-0.010147656314074993,
-0.03533153235912323,
0.02581735886633396,
-0.006741199176758528,
-0.004954303149133921,
0.023414909839630127,
0.018203627318143845,
0.016374899074435234,
0.021394940093159676,
-0.055411700159311295,
0.017103999853134155,
0.0075599439442157745,
0.029570437967777252,
0.012693534605205059,
0.05832810699939728,
-0.011958456598222256,
0.019004443660378456,
-0.06430434435606003,
-0.05708504840731621,
-0.0106675885617733,
-0.01685299724340439,
0.06234413757920265,
0.033275704830884933,
-0.027299465611577034,
-0.005901537369936705,
0.025148019194602966,
0.025100208818912506,
0.005008089356124401,
-0.0060658841393888,
0.021550321951508522,
0.018884919583797455,
0.01809605583548546,
0.006227242294698954,
-0.0031733836513012648,
-0.053069014102220535,
-0.02196865901350975,
0.011247284710407257,
0.04355483874678612,
-0.00468836072832346,
0.023175859823822975,
0.018693679943680763,
0.017952626571059227,
0.018932729959487915,
-0.0035319579765200615,
-0.03248684108257294,
-0.030956925824284554,
0.009059980511665344,
0.016099991276860237,
0.0024472703225910664,
0.03779374435544014,
-0.018717585131525993,
-0.04171415790915489,
0.0363355427980423,
-0.00003370972990524024,
0.002668391214683652,
0.022661903873085976,
-0.0027684932574629784,
0.0000852548037073575,
-0.04111653193831444,
-0.0294509120285511,
-0.009723342955112457,
0.022255519405007362,
0.025219734758138657,
-0.039586614817380905,
-0.027179941534996033,
-0.01058392133563757,
-0.02419182099401951,
0.06478244811296463,
-0.019100064411759377,
0.043196264654397964,
0.031148165464401245,
-0.05488578975200653,
-0.02937919832766056,
-0.03384942561388016,
-0.006687412969768047,
0.0007918518385849893,
-0.08127687126398087,
-0.0052053052932024,
-0.02902062237262726,
-0.02321171760559082,
0.06846380978822708,
0.019685735926032066,
-0.0713324025273323,
0.044487133622169495,
-0.015382842160761356,
0.026008598506450653,
-0.0101536326110363,
-0.0162673257291317,
-0.005641570780426264,
0.023462720215320587,
0.017175715416669846,
0.018227532505989075,
-0.05459893122315407,
-0.04584971442818642,
-0.018490487709641457,
0.004801908973604441,
-0.02679746225476265,
0.019243493676185608,
-0.00410866504535079,
0.03874994069337845,
-0.020618028938770294,
0.0019482542993500829,
-0.04735573008656502,
-0.04042328894138336,
0.025936882942914963,
0.0057640839368104935,
0.022769475355744362,
0.022195756435394287,
-0.02360614947974682,
-0.029618246480822563,
-0.06631236523389816,
0.021741561591625214,
-0.03906070813536644,
-0.03363427892327309,
0.011247284710407257,
-0.05445550009608269,
-0.0009464870672672987,
0.007524086628109217,
-0.023785436525940895,
-0.0036275777965784073,
-0.0002956371463369578,
0.0019243493443354964,
-0.003600684693083167,
-0.00026183403679169714,
-0.040853578597307205,
0.0242635365575552,
-0.03418409451842308,
0.020474599674344063,
0.043076738715171814,
-0.029474817216396332,
-0.002849172567948699,
0.015191602520644665,
-0.027442894876003265,
0.005501129198819399,
-0.00704001123085618,
-0.005405509378761053,
-0.039777856320142746,
0.03745907545089722,
0.004296917002648115,
0.03050273098051548,
-0.006926462519913912,
0.02138298749923706,
-0.012597914785146713,
0.007458347827196121,
-0.021155890077352524,
0.0391085185110569,
-0.008163544349372387,
-0.010291085578501225,
0.012741344049572945,
-0.007231250870972872,
-0.0073746806010603905,
-0.009394649416208267,
0.018108008429408073,
-0.013506303541362286,
0.00458975275978446,
0.020223597064614296,
0.025004589930176735,
0.03148283436894417,
-0.04905297979712486,
0.03043101541697979,
0.004996136762201786,
0.03525981679558754,
-0.010619779117405415,
0.03442314267158508,
0.0017480503302067518,
0.009418554604053497,
-0.04486961290240288,
0.01911201700568199,
-0.004180380143225193,
-0.011139712296426296,
-0.03827184438705444,
-0.03447095304727554,
0.030120251700282097,
0.010721375234425068,
-0.03702878579497337,
-0.0307178758084774,
0.026080312207341194,
0.02363005466759205,
0.06114888936281204,
0.01099628210067749,
0.023402957245707512,
-0.00298662600107491,
0.034638289362192154,
0.008044019341468811,
0.017594052478671074,
-0.025410974398255348,
-0.008283069357275963,
0.001592668006196618,
-0.0037620433140546083,
-0.023402957245707512,
-0.031172068789601326,
-0.0019572186283767223,
0.05928430333733559,
0.00643043452873826,
0.0006289993179962039,
0.002895488403737545,
0.008994241245090961,
-0.034829527139663696,
-0.046997152268886566,
0.013398731127381325,
0.002707236912101507,
0.028925003483891487,
0.002224655356258154,
-0.052973393350839615,
0.0678422823548317,
0.0048885648138821125,
0.01290867943316698,
-0.004440346732735634,
0.029785580933094025,
0.045754097402095795,
-0.0008389147114939988,
0.014354929327964783,
-0.04628000408411026,
-0.031219879165291786,
0.021490560844540596,
0.05622446909546852,
-0.04883783683180809,
-0.060192693024873734,
0.01577727496623993,
0.033538661897182465,
-0.03320399299263954,
0.00767946895211935,
-0.005309889558702707,
-0.01755819469690323,
0.07472690939903259,
-0.003481159918010235,
0.047021057456731796,
0.023343194276094437,
0.003185336012393236,
-0.01577727496623993,
-0.021861087530851364,
-0.026486696675419807,
-0.05861496552824974,
0.03573791682720184,
-0.019076159223914146,
-0.0007111725863069296,
0.024466728791594505,
0.026630127802491188,
-0.01819167472422123,
-0.016398804262280464,
0.051730334758758545,
0.029498722404241562,
0.03779374435544014,
0.009257196448743343,
-0.035307627171278,
-0.0057640839368104935,
0.06502149254083633,
-0.019936738535761833,
0.020271407440304756,
0.0005307648680172861,
-0.04489351809024811,
0.017127905040979385,
-0.006693389266729355,
-0.01229910273104906,
-0.0424313060939312,
0.026606222614645958,
-0.01894468255341053,
-0.015179650858044624,
-0.05751533806324005,
-0.003280955832451582,
0.06669484078884125,
-0.06353938579559326,
0.000008760094715398736,
0.008868740871548653,
0.022853143513202667,
-0.020522410050034523,
0.039610520005226135,
-0.01650637574493885,
0.020809268578886986,
-0.012514247559010983,
0.0007440419285558164,
0.006514101754873991,
-0.034781720489263535,
0.02250652201473713,
0.0121317682787776,
-0.04020814597606659,
0.00885081198066473,
0.00535769946873188,
-0.027251655235886574,
0.005817870143800974,
-0.01882515661418438,
0.056654758751392365,
-0.011235332116484642,
0.008091829717159271,
-0.03820012882351875,
0.05493360012769699,
-0.02391691319644451,
0.010948472656309605,
0.016255373135209084,
0.028829382732510567,
-0.006239194888621569,
-0.00921536237001419,
-0.03937147185206413,
-0.015621892176568508,
0.011271188966929913,
0.009346839971840382,
-0.010876757092773914,
0.013255300931632519,
-0.009054004214704037,
-0.007858755998313427,
0.0034961006604135036,
-0.039514899253845215,
-0.055507320910692215,
0.026343267410993576,
0.0436982698738575,
-0.008247211575508118,
0.015550177544355392,
-0.006890605203807354,
-0.016984475776553154,
-0.0044791921973228455,
0.0238691046833992,
-0.00762568274512887,
-0.020546313375234604,
0.061770420521497726,
0.023665912449359894,
-0.018418772146105766,
0.037363454699516296,
0.0036395303905010223,
0.04991355910897255,
0.004192332737147808,
-0.010183513164520264,
0.03267808258533478,
-0.010876757092773914,
-0.015131840482354164,
-0.013482398353517056,
0.010619779117405415,
-0.025100208818912506,
-0.06334814429283142,
0.01410392764955759,
0.0022321257274597883,
0.030813494697213173,
0.0042849644087255,
0.014952553436160088,
0.02918795868754387,
0.002634027972817421,
0.012263244949281216,
0.07357946783304214,
-0.007667516358196735,
0.015215507708489895,
0.007613730151206255,
0.01589679904282093,
0.0009121237089857459,
-0.02145470306277275,
-0.003158442908897996,
-0.0052351863123476505,
-0.033562567085027695,
-0.002143976278603077,
-0.017952626571059227,
-0.0007212575292214751,
-0.013530207797884941,
0.0104106105864048,
-0.011647691950201988,
0.009818962775170803,
0.028279569000005722,
-0.028303474187850952,
-0.03992128372192383,
0.01006996538490057,
-0.04039938375353813,
-0.0368136391043663,
0.007691421080380678,
-0.03762640804052353,
-0.005405509378761053,
0.02433525025844574,
-0.06110108271241188,
0.020809268578886986,
-0.03820012882351875,
-0.002097660442814231,
-0.04780992120504379,
-0.02545878291130066,
-0.0013125317636877298,
-0.003633554093539715,
0.0009756212239153683,
-0.00637664832174778,
-0.01850244030356407,
0.03674192726612091,
0.02180132456123829,
-0.0024547406937927008,
-0.01687690243124962,
-0.020355073735117912,
0.026558412238955498,
-0.028303474187850952,
0.006806937512010336,
0.013291158713400364,
-0.006143575068563223,
0.031219879165291786,
-0.006741199176758528,
-0.021837182343006134,
0.012526200152933598,
0.005659499671310186,
-0.019590115174651146,
-0.01582508347928524,
-0.0016180670354515314,
-0.03315618261694908,
0.00879104994237423,
-0.013697543181478977,
0.016195612028241158,
-0.011815027333796024,
-0.04795335233211517,
0.021980611607432365,
-0.04420027509331703,
-0.04228787496685982,
-0.0009666568948887289,
0.0023501564282923937,
-0.0017883898690342903,
-0.019865022972226143,
-0.030837399885058403,
0.017916768789291382,
-0.028709858655929565,
-0.0022127029951661825,
-0.021622037515044212,
0.010446468368172646,
0.012980394065380096,
0.026558412238955498,
-0.02682136744260788,
0.0046315863728523254,
-0.019351067021489143,
-0.0017435681074857712,
0.009185481816530228,
0.019100064411759377,
0.03667021170258522,
-0.0075479913502931595,
0.03050273098051548,
-0.02440696582198143,
-0.032056551426649094,
0.007739231456071138,
0.013374825939536095,
-0.01134888082742691,
-0.018562203273177147,
0.015346985310316086,
0.0034393263049423695,
-0.011008234694600105,
-0.010189489461481571,
-0.028303474187850952,
-0.003705268958583474,
0.0043596671894192696,
0.05330806225538254,
-0.02696479670703411,
0.014856933616101742,
-0.0005188123905099928,
-0.013876830227673054,
0.02902062237262726,
0.008127686567604542,
-0.0026071348693221807,
0.02116784267127514,
0.009962392970919609,
0.03631163761019707,
0.01006996538490057,
0.00790059007704258,
0.0076197064481675625,
-0.04147510975599289,
0.015860941261053085,
0.015717511996626854,
0.022936809808015823,
0.013219444081187248,
-0.07094992697238922,
-0.029976822435855865,
-0.022709712386131287,
0.048311926424503326,
-0.014749361202120781,
0.01723547652363777,
-0.018693679943680763,
-0.010595873929560184,
0.015179650858044624,
-0.04295721650123596,
0.011366808786988258,
0.02694089151918888,
-0.046973250806331635,
0.004634574521332979,
-0.0023456744384020567,
-0.012054076418280602,
0.0009218350751325488,
-0.021598132327198982,
0.014390787109732628,
-0.028542524203658104,
-0.007924494333565235,
-0.027108225971460342,
-0.031124260276556015,
0.027323370799422264,
-0.006669484078884125,
-0.013673637993633747,
-0.03511638939380646,
0.025865167379379272,
-0.0009203410008922219,
0.02119174785912037,
-0.004024997819215059,
-0.013111871667206287,
-0.005297936964780092,
0.0023531445767730474,
0.054312072694301605,
-0.017761386930942535,
-0.004401500802487135,
-0.0036365422420203686,
0.0229965727776289,
-0.0010107316775247455,
0.009281101636588573,
0.013697543181478977,
0.010141680017113686,
0.021442750468850136,
-0.010332919657230377,
0.051825955510139465,
0.017833100631833076,
0.03569010645151138,
0.04147510975599289,
0.038439176976680756,
-0.013649732805788517,
0.027395086362957954,
-0.011540120467543602,
-0.018227532505989075,
-0.009908606298267841,
0.010733327828347683,
0.00798425730317831,
0.003848698688670993,
-0.005489176604896784,
0.021227605640888214,
0.001509747700765729,
-0.0026863201055675745,
0.028327379375696182,
0.004180380143225193,
-0.009448436088860035,
0.046925440430641174,
-0.03408847376704216,
-0.030191965401172638,
-0.043124549090862274,
-0.025889072567224503,
0.00507681630551815,
-0.0009980321628972888,
0.004222213756293058,
-0.01694861799478531,
-0.0467102937400341,
0.017809195443987846,
0.028972813859581947,
-0.019076159223914146,
-0.027156036347150803,
0.004951315000653267,
-0.011611835099756718,
-0.022147946059703827,
-0.0042461189441382885,
0.06927657872438431,
-0.012042123824357986,
-0.019793307408690453,
-0.01073930412530899,
0.024108152836561203,
0.0018645869567990303,
0.0044313822872936726,
0.023737626150250435,
-0.005725238472223282,
0.024275489151477814,
0.030168062075972557,
-0.01687690243124962,
0.006693389266729355,
0.02192084863781929,
0.017546242102980614,
-0.005474236328154802,
0.0001534212933620438,
0.02665403112769127,
-0.027753660455346107,
0.06913314759731293,
-0.028590334579348564,
0.005501129198819399,
-0.0031166092958301306,
-0.019888928160071373,
0.002982144011184573,
-0.016984475776553154,
-0.032295603305101395,
0.048144593834877014,
-0.016805188730359077,
-0.03664630651473999,
-0.011856860481202602,
0.0026400042697787285,
0.009233291260898113,
-0.05086975917220116,
-0.029522627592086792,
-0.053212445229291916,
0.006466291844844818,
0.019446685910224915,
0.009137671440839767,
-0.01650637574493885,
-0.0025339259300380945,
-0.0393475666642189,
-0.008354783989489079,
0.008617738261818886,
-0.011988338083028793,
-0.008235258981585503,
0.0019094088347628713,
-0.03545105829834938,
0.020486552268266678,
0.009908606298267841,
0.0039413305930793285,
-0.021956706419587135,
-0.04910079017281532,
-0.019446685910224915,
-0.016637852415442467,
-0.005372640211135149,
0.024227678775787354,
0.014115879312157631,
0.008300998248159885,
0.023175859823822975,
-0.03067006543278694,
0.0393475666642189,
-0.0319848395884037,
-0.03258246183395386,
-0.00042842174298129976,
-0.001347642159089446,
0.013111871667206287,
-0.011390713974833488,
-0.03509248420596123,
-0.0162673257291317,
-0.00023587472969666123,
0.007518110331147909,
-0.02060607634484768,
-0.010554040782153606,
0.00826514046639204,
-0.015442605130374432,
0.012956488877534866,
0.022291377186775208,
0.00405487883836031,
0.0017525324365124106,
-0.036120396107435226,
-0.03193702921271324,
-0.006197361275553703,
0.028614237904548645,
-0.020426789298653603,
0.009591865353286266,
0.016350993886590004,
0.042144447565078735,
-0.00879104994237423,
-0.07711740583181381,
-0.024227678775787354,
-0.022745570167899132,
-0.05995364487171173,
-0.02370176836848259,
0.004027985967695713,
-0.015239412896335125,
0.010177536867558956,
0.03368208929896355,
-0.012848916463553905,
0.029785580933094025,
-0.022195756435394287,
0.02914014831185341,
0.009382697753608227,
-0.01283696386963129,
-0.024299392476677895,
-0.0015224472153931856,
-0.03643115982413292,
-0.004706289153546095,
-0.003875591792166233,
0.0007100520306266844,
0.02269776165485382,
-0.021598132327198982,
0.03191312402486801,
-0.045610666275024414,
0.025004589930176735,
-0.04489351809024811,
-0.01582508347928524,
-0.024741634726524353,
-0.05101318657398224,
-0.030837399885058403,
-0.012490342371165752,
-0.027227750048041344,
0.010781137272715569,
0.0029940963722765446,
-0.02574564330279827,
0.006818890105932951,
-0.008976313285529613,
0.01840681955218315,
-0.0037291739135980606,
0.03169797733426094,
0.028518619015812874,
-0.006890605203807354,
0.019351067021489143,
-0.052925582975149155,
-0.005674440413713455,
-0.005922453943639994,
-0.000463532138383016,
0.0033287659753113985,
0.0039293779991567135,
0.022781427949666977,
-0.021131986752152443,
-0.0441763699054718,
-0.018538298085331917,
0.008444427512586117,
0.0009390167542733252,
-0.021096128970384598,
0.017689671367406845,
-0.0023949784226715565,
-0.004111653193831444,
0.008838859386742115,
-0.004547918681055307,
0.013876830227673054,
-0.028877193108201027,
-0.019876975566148758,
-0.0035588510800153017,
0.004030974116176367,
0.0049901604652404785,
-0.015490414574742317,
0.000559525506105274,
0.004547918681055307,
0.003735150210559368,
-0.07042401283979416,
0.022052327170968056,
0.027442894876003265,
-0.02206427976489067,
0.0015343996929004788,
-0.016637852415442467,
0.023104144260287285,
0.021060271188616753,
-0.02396472357213497,
-0.009914582595229149,
-0.028470808640122414,
0.020952697843313217,
0.0029193933587521315,
-0.023928865790367126,
0.020641934126615524,
0.026295457035303116,
0.0010540593648329377,
-0.025984693318605423,
-0.004042926710098982,
-0.019207635894417763,
0.012526200152933598,
0.02423963136970997,
0.014450549148023129,
0.004927410278469324,
-0.0020408860873430967,
-0.01657809130847454,
-0.008994241245090961,
-0.007135631050914526,
0.041905395686626434,
0.02440696582198143,
-0.03279760852456093,
-0.007428466808050871,
-0.013159681111574173,
0.007798993494361639,
-0.011032139882445335,
0.011671597138047218,
-0.013661685399711132,
-0.01458202674984932,
0.058949634432792664,
-0.0034662194084376097,
0.03043101541697979,
-0.007440419401973486,
-0.002483127871528268,
0.004120617639273405,
0.04130777344107628,
-0.021096128970384598,
0.012430580332875252,
-0.013267253525555134,
0.044415418058633804,
0.018550250679254532,
-0.012263244949281216,
-0.013315063901245594,
-0.0034961006604135036,
-0.015370890498161316,
-0.010799066163599491,
0.010446468368172646,
-0.013960497453808784,
-0.027634134516119957,
-0.013087966479361057,
-0.0033198015298694372,
-0.009018146432936192,
-0.010601850226521492,
-0.002753552747890353,
0.005465271882712841,
0.021645942702889442,
0.032104361802339554,
-0.0002932093048002571,
-0.010984329506754875,
0.017103999853134155,
-0.020104072988033295,
-0.003092704340815544,
0.016147801652550697,
0.020940745249390602,
0.002175351371988654,
-0.04644734039902687,
-0.019255446270108223,
0.038558702915906906,
-0.011570001021027565,
0.01333896815776825,
-0.035307627171278,
0.022351138293743134,
0.037315644323825836,
0.009759200736880302,
0.026510601863265038,
0.027060415595769882,
0.004030974116176367,
-0.02543487958610058,
0.008575905114412308,
-0.008330878801643848,
0.02384519949555397,
-0.038510892540216446,
-0.010099845938384533,
0.006496173329651356,
-0.010404634289443493,
-0.016135849058628082,
0.0015187120297923684,
0.040781863033771515,
0.002264995127916336,
0.0039293779991567135,
-0.06401748955249786,
0.014892790466547012,
-0.006484220735728741,
0.020343123003840446,
0.0037441146560013294,
0.02431134507060051,
0.024275489151477814,
0.005426426418125629,
0.016805188730359077,
-0.0037112452555447817,
-0.002099154517054558,
0.0011287623783573508,
0.02560221403837204,
0.05976240336894989,
-0.03674192726612091,
-0.03525981679558754,
-0.020976603031158447,
0.03772202879190445,
-0.004075795877724886,
-0.007673492655158043,
0.0140322120860219,
0.019004443660378456,
0.009221338666975498,
0.012066029012203217,
0.019542306661605835,
-0.02355833910405636,
-0.0052949488162994385,
-0.015418699942529202,
-0.0061256461776793,
-0.041044820100069046,
0.030191965401172638,
0.06105327233672142,
-0.004138546530157328,
-0.03040711022913456,
0.018633916974067688,
0.03064616024494171,
-0.06545178592205048,
-0.026414982974529266,
0.0426703542470932,
0.011247284710407257,
0.02930748276412487,
-0.038367461413145065,
0.021610084921121597,
0.015442605130374432,
0.019518401473760605,
-0.017713576555252075,
0.007476276718080044,
-0.008026090450584888,
-0.011085925623774529,
0.009621746838092804,
-0.034757815301418304,
0.010828947648406029,
-0.01718766801059246,
-0.026558412238955498,
0.051969386637210846,
0.05741971731185913,
0.028996717184782028,
0.004389548674225807,
0.022267471998929977,
-0.02421572618186474,
0.012000290676951408,
0.00532781844958663,
0.01964987814426422,
-0.006021061912178993,
0.013064061291515827,
0.008838859386742115,
-0.008773121051490307,
0.009830915369093418,
-0.015562130138278008,
0.06688608229160309,
-0.0025697832461446524,
-0.017785292118787766,
-0.030239775776863098,
-0.01850244030356407,
0.016637852415442467,
0.026391077786684036,
-0.029546532779932022,
-0.027801470831036568,
-0.002893994329497218,
-0.022147946059703827,
-0.010428539477288723,
0.013147728517651558,
-0.01933911442756653,
0.01277720183134079,
0.024980684742331505,
-0.02180132456123829,
0.0015403759898617864,
0.0238691046833992,
0.005590772721916437,
-0.01645856536924839,
0.007075868546962738,
-0.013291158713400364,
0.00614955136552453,
0.004222213756293058,
0.005262079648673534,
-0.0008389147114939988,
-0.018633916974067688,
0.053069014102220535,
0.011313023045659065,
-0.014127831906080246,
0.016099991276860237,
-0.02323562279343605,
0.02033117040991783,
0.009095837362110615,
-0.0019258434185758233,
0.01408002246171236,
-0.029642151668667793,
0.03318008780479431,
-0.019685735926032066,
0.007667516358196735,
-0.008139639161527157,
0.021765466779470444,
0.031028639525175095,
0.027442894876003265,
-0.01520355511456728,
-0.03499686345458031,
-0.028685953468084335,
0.04463056102395058,
-0.02011602558195591,
-0.032295603305101395,
-0.02674965187907219,
0.0027684932574629784,
-0.03805669769644737,
0.0017719552852213383,
-0.03535543754696846,
0.01629123091697693,
-0.0057850005105137825,
0.028351284563541412,
-0.02055826596915722,
0.02363005466759205,
-0.005172436125576496,
-0.009185481816530228,
0.018370963633060455,
-0.001264721853658557,
-0.02135908231139183,
-0.04283769056200981,
-0.029618246480822563,
0.0036395303905010223,
0.024024486541748047,
-0.033275704830884933,
0.0242635365575552,
-0.003726185765117407,
-0.0017032284522429109,
0.00971736665815115,
-0.00132597831543535,
0.011390713974833488,
-0.015884846448898315,
0.02023554965853691,
0.010338895954191685,
0.007105749566107988,
0.017343049868941307,
-0.011038116179406643,
-0.010948472656309605,
-0.03772202879190445,
-0.022267471998929977,
0.01290867943316698,
-0.012980394065380096,
0.010374752804636955,
0.017761386930942535,
0.027108225971460342,
0.0016105967806652188,
0.00729101337492466,
0.0009741271496750414,
0.027801470831036568,
-0.006950367707759142,
0.011725383810698986,
-0.027084320783615112,
-0.013147728517651558,
0.01882515661418438,
-0.0020767434034496546,
0.006777056492865086,
0.001532905618660152,
-0.00782887451350689,
-0.006687412969768047,
-0.009729319252073765,
-0.008689453825354576,
0.02394081838428974,
0.005282996688038111,
-0.008659572340548038,
0.05397740378975868,
0.009322934783995152,
-0.04905297979712486,
0.034518763422966,
0.04584971442818642,
0.027108225971460342,
0.014068069867789745,
0.008247211575508118,
0.008199402131140232,
0.016099991276860237,
-0.009508198127150536,
0.016637852415442467,
-0.0330127514898777,
-0.020355073735117912,
0.0280644241720438,
0.0024024485610425472,
-0.033371325582265854,
0.0033915163949131966,
-0.0426703542470932,
0.010554040782153606,
-0.004661467391997576,
0.08414546400308609,
-0.045491140335798264,
0.004147510975599289,
0.01870563253760338,
0.030956925824284554,
0.04016033560037613,
0.01349435094743967,
-0.005504117347300053,
0.0330127514898777,
-0.018621964380145073,
-0.020390931516885757,
-0.009209386073052883,
-0.004332774318754673,
0.01601632498204708,
-0.007117702160030603,
-0.02423963136970997,
-0.008061948232352734,
0.01043451577425003,
0.020534362643957138,
0.009227314963936806,
-0.02928357757627964,
0.0014365387614816427,
0.002048356458544731,
0.016195612028241158,
0.017761386930942535,
0.0053039132617414,
0.029713867232203484,
0.012048100121319294,
0.02684527076780796,
-0.032343413680791855,
-0.005474236328154802,
0.009514174424111843,
-0.009012170135974884,
0.0030344361439347267,
0.023785436525940895,
0.010637708008289337,
0.011032139882445335,
0.012066029012203217,
-0.0025981704238802195,
-0.02428743988275528,
0.011725383810698986,
-0.0467102937400341,
0.03803279250860214,
-0.0021977624855935574,
-0.0027684932574629784,
0.020964650437235832,
0.01786895841360092,
-0.02318781241774559,
-0.0414033941924572,
0.00014977951650507748,
-0.03031149134039879,
0.01694861799478531,
-0.01784505322575569,
-0.02086903154850006,
0.042216163128614426,
-0.009251220151782036,
0.02689308114349842,
0.011731360107660294,
-0.016817139461636543,
0.00732089439406991,
0.016374899074435234,
-0.003552874783053994,
-0.004858683329075575,
0.013135775923728943,
0.014378834515810013,
0.01682909205555916,
0.02128736861050129,
-0.02316390722990036,
0.016327088698744774,
-0.016661757603287697,
0.03688535466790199,
-0.007565920241177082,
-0.012585962191224098,
0.010900662280619144,
-0.015060125850141048,
-0.01470155082643032,
-0.0020304275676608086,
-0.0007533797761425376,
-0.013040156103670597,
0.007147583644837141,
0.03915632516145706,
-0.032343413680791855,
0.022865096107125282,
-0.015884846448898315,
-0.0034572549629956484,
-0.015956562012434006,
-0.006878652609884739,
0.04501304402947426,
0.019100064411759377,
-0.020032357424497604,
-0.021610084921121597,
0.006056919693946838,
-0.023785436525940895,
0.002312805037945509,
0.014833028428256512,
-0.017271334305405617,
-0.04271816462278366,
-0.016303183510899544,
0.03165016695857048,
-0.035905253142118454,
0.002926863729953766,
0.000045615521230502054,
-0.019446685910224915,
0.009466364979743958,
-0.033443041145801544,
0.014892790466547012,
0.024371108040213585,
-0.03062225505709648,
-0.003944318741559982,
-0.007565920241177082,
0.021000508219003677,
-0.011570001021027565,
0.026271551847457886,
0.0027490705251693726,
0.007613730151206255,
-0.0001632260682526976,
-0.0317457877099514,
0.03045492060482502,
0.01967378333210945,
-0.002695284318178892,
-0.00735077541321516,
-0.01097237691283226,
0.002170869382098317,
0.017139857634902,
-0.0015299174701794982,
0.005360687617212534,
-0.029689962044358253,
0.023618102073669434,
-0.002737118164077401,
0.009221338666975498,
0.051778145134449005,
-0.0035259819123893976,
-0.005438378546386957,
0.006657531950622797,
-0.007745207287371159,
-0.032056551426649094,
-0.06076641008257866,
0.020618028938770294,
-0.005139566492289305,
-0.04128386825323105,
-0.015765322372317314,
-0.01899249106645584,
0.029618246480822563,
0.041977111250162125,
0.016697615385055542,
-0.001218406017869711,
0.03162626549601555,
0.00456584757193923,
0.008396618068218231,
0.020462647080421448,
0.005743166897445917,
0.031100355088710785,
-0.028925003483891487,
-0.008540047332644463,
-0.0189207773655653,
-0.011307046748697758,
0.0005165712791495025,
-0.014223451726138592,
-0.009938487783074379,
0.04792944714426994,
0.0063467673026025295,
0.011659644544124603,
-0.027084320783615112,
-0.016793236136436462,
0.02789708971977234,
-0.022614093497395515,
-0.00349311251193285,
-0.0005468259914778173,
-0.0015194590669125319,
-0.002632533898577094,
-0.008707381784915924,
0.010870780795812607,
-0.008354783989489079,
0.0011974892113357782,
0.02940310165286064,
0.027251655235886574,
-0.007637635339051485,
0.04914860054850578,
0.03389723598957062,
0.002478645648807287,
-0.014856933616101742,
-0.006167480256408453,
-0.03776983916759491,
-0.008306973613798618,
0.02455039508640766,
0.016697615385055542,
0.035307627171278,
-0.018693679943680763,
0.017785292118787766,
-0.014235404320061207,
-0.02011602558195591,
-0.014522263780236244,
0.04761868342757225,
0.00859383400529623,
0.00298662600107491,
-0.024072296917438507,
0.006203337572515011,
-0.046973250806331635,
-0.0024293416645377874,
-0.008306973613798618,
-0.01349435094743967,
-0.01762990839779377,
0.004278988111764193,
-0.009054004214704037,
0.0007608500891365111,
-0.003113621147349477,
0.00937672145664692,
-0.018693679943680763,
-0.03435143083333969,
0.005626630503684282,
-0.028399094939231873,
-0.012042123824357986,
-0.0008172508678399026,
-0.022303329780697823,
-0.01782114803791046,
0.005859703756868839,
-0.027466800063848495,
0.04233568534255028,
-0.020785363391041756,
-0.012968441471457481,
-0.004975220188498497,
-0.023104144260287285,
0.025267543271183968,
-0.0086296908557415,
0.007906566374003887,
-0.003155454993247986,
0.011653668247163296,
-0.02581735886633396,
-0.026630127802491188,
0.021084176376461983,
0.027490705251693726,
-0.01889687217772007,
-0.012490342371165752,
0.04410465434193611,
-0.021956706419587135,
0.002680343808606267,
-0.02084512636065483,
-0.043124549090862274,
-0.00796035211533308,
-0.022398948669433594,
-0.009167552925646305,
-0.0025145031977444887,
0.03184140846133232,
0.011032139882445335,
0.009747248142957687,
-0.04288550093770027,
0.02550659328699112,
0.029546532779932022,
-0.00938867311924696,
0.004422417841851711,
0.03626382723450661,
-0.005040958523750305,
0.0006573864375241101,
-0.024837255477905273,
-0.0243830606341362,
-0.034710004925727844,
0.0004534472245723009,
0.023570291697978973,
0.021371034905314445,
-0.04408074915409088,
0.04410465434193611,
0.006657531950622797,
-0.028996717184782028,
-0.003911449108272791,
-0.0004048902774229646,
-0.018669774755835533,
0.021418845281004906,
-0.03267808258533478,
-0.0036933165974915028,
0.0010846876539289951,
0.03193702921271324,
-0.03131549805402756,
-0.0013334485702216625,
-0.0436982698738575,
0.012585962191224098,
-0.04293331131339073,
-0.0312676876783371,
0.016398804262280464,
-0.0051216380670666695,
-0.028351284563541412,
0.016470517963171005,
0.015119887888431549,
0.014713503420352936,
0.02909233793616295,
-0.013936592265963554,
0.008755192160606384,
-0.023379052057862282,
-0.026462791487574577,
-0.0031644192058593035,
-0.006860723719000816,
-0.01624342054128647,
0.007948399521410465,
0.026558412238955498,
0.007093797437846661,
-0.013398731127381325,
0.004150499124079943,
0.027801470831036568,
-0.02698870189487934,
0.009538079611957073,
0.02902062237262726,
0.035307627171278,
0.002235113875940442,
-0.001976641593500972,
0.11971604824066162,
0.013601923361420631,
-0.03674192726612091,
-0.02318781241774559,
-0.01002215500921011,
-0.017139857634902,
0.035857442766427994,
0.0024278475902974606,
0.003905473044142127,
-0.012036148458719254,
0.01938692294061184,
0.021096128970384598,
0.03674192726612091,
0.04601705074310303,
0.034853432327508926,
-0.023570291697978973,
-0.02067779190838337,
0.007661540061235428,
0.010787113569676876,
0.002905946923419833,
0.012693534605205059,
0.008976313285529613,
0.02131127379834652,
0.020594123750925064,
-0.0042550829239189625,
0.014283214695751667,
-0.0038845562376081944,
-0.026199838146567345,
-0.004198309034109116,
-0.03387333080172539,
-0.00614955136552453,
0.017785292118787766,
0.01875344291329384,
-0.004712265450507402,
-0.002955250907689333,
-0.008832883089780807,
-0.006364695727825165,
-0.02665403112769127,
-0.015645796433091164,
0.031028639525175095,
-0.0041863564401865005,
-0.03992128372192383,
-0.003938342444598675,
-0.006908533629029989,
0.03188921883702278,
-0.013219444081187248,
-0.03055054135620594,
0.023665912449359894,
0.01621951535344124,
-0.030024630948901176,
0.0034990888088941574,
0.054407693445682526,
0.018741490319371223,
-0.006543983239680529,
-0.03652678057551384,
-0.021622037515044212,
0.005073828157037497,
-0.012585962191224098,
0.017008379101753235,
-0.011247284710407257,
-0.01568165421485901,
0.029857296496629715,
-0.021323226392269135,
-0.03674192726612091,
-0.010536111891269684
] | 2025-01-23 | 60 | 39843688 | [
"cancer cells",
"small cell lung cancer",
"immune checkpoint inhibitors",
"new therapies",
"other cancers",
"chimeric antigen receptor T cells",
"receptor radionuclide therapy",
"bispecific T cell engagers",
"immune attack",
"NENs",
"cancer vaccines",
"new hope",
"other therapeutic agents",
"innovative approaches",
"cytotoxic chemotherapy",
"mTOR inhibitors",
"dual ICIs",
"growing enthusiasm",
"NETs range",
"NECs",
"neuroendocrine neoplasms",
"clinical trials",
"somatostatin analogues",
"patients",
"considerable promise",
"oncolytic viruses",
"chemotherapy",
"tumor-infiltrating lymphocytes",
"ICIs",
"Treatment options"
] | [
"Gastroenteropancreatic neuroendocrine cancers",
"Immune checkpoint inhibitors",
"Immunotherapy",
"Neuroendocrine carcinoma",
"Neuroendocrine tumor"
] | 0 | 10.1007/s11864-024-01283-4
10.1007/s00428-006-0250-1
10.1007/s00428-007-0452-1
10.1093/annonc/mds276
10.1111/cas.12473
10.1111/jne.13249
10.1056/NEJMoa1809064
10.1016/S0140-6736(19)32222-6
10.7150/jca.13711
10.1002/cncr.32883
10.1530/ERC-20-0382
10.1158/1078-0432.CCR-19-3014
10.1158/1078-0432.CCR-19-3356
10.1002/cncr.33591
10.1038/s41467-023-38611-5
10.1038/s41467-024-50969-8
10.1158/1078-0432.CCR-20-0621
10.1016/j.lungcan.2020.03.008
10.1136/jitc-2020-000980
10.1158/1078-0432.CCR-14-1191
10.3389/fonc.2021.729765
10.1007/s12022-020-09657-8
10.1093/oncolo/oyac161
10.1158/1078-0432.CCR-18-1278
10.1267/ahc.12006
10.1038/s41698-021-00214-y
10.1056/NEJMoa2307980
10.1016/j.lungcan.2020.04.017
10.1136/jitc-2022-SITC2022.0697
10.1002/JLB.5MA0122-467R
10.1016/j.jtho.2018.10.003
10.1016/j.jtho.2019.12.109
10.1186/s13045-023-01464-y
10.1016/j.annonc.2023.09.672
10.1158/2159-8290.CD-12-0548
10.1111/his.12610
10.1038/s43018-022-00344-7
10.1136/jitc-2023-SITC2023.0702
10.1136/jitc-2022-004854
10.3390/cells8080880
10.3390/cancers13061339
10.1158/0008-5472.CAN-17-0299
10.1200/JCO.21.00612
10.1158/2159-8290.CD-23-1334
10.1136/jitc-2020-001188
10.1159/000518106
10.1158/1078-0432.CCR-10-1706
10.1002/cam4.1185
10.1158/1078-0432.CCR-06-2532
10.1159/000448430
10.1159/000500159
10.18632/oncotarget.27391
10.1186/s12885-020-07121-8
10.1158/0008-5472.CAN-15-3308
10.1200/JCO.2017.73.7379
10.1038/s41392-023-01674-3
10.1038/25141
10.1007/s00432-022-04013-1
10.18632/oncotarget.27631
10.1007/s00262-016-1890-x
10.1200/JCO.22.00996 | [
"Urman",
"Schonman",
"De Jesus-Acosta"
] | [
"The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.",
"Johns Hopkins Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.",
"The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. [email protected]."
] | [
"39843688",
"16967267",
"17674042",
"22967994",
"24975505",
"36924180",
"30280641",
"31590988",
"26958083",
"32320048",
"33480358",
"31980466",
"31969335",
"33882143",
"37221181",
"39117670",
"32532787",
"32203769",
"33428585",
"25991820",
"34568063",
"33409812",
"35983951",
"30327311",
"22829710",
"34354225",
"37861218",
"32438272",
"35088475",
"30316010",
"31870883",
"37355629",
"23550147",
"25388236",
"35314826",
"36650021",
"35764366",
"31412616",
"33809582",
"28487384",
"33979178",
"38563600",
"33428583",
"34348340",
"21304001",
"28941156",
"17438105",
"27442441",
"31280274",
"31903171",
"32631270",
"29259007",
"28981385",
"38086815",
"9859993",
"9850056",
"35428913",
"32577168",
"27576783",
"36521103"
] | [] | 11.116188 | 5.0375 |
39841845 | 4 | Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity. | A major limiting factor in the success of chimeric antigen receptor (CAR) T cell therapy for the treatment of solid tumors is targeting tumor antigens also found on normal tissues. CAR T cells against GD2 induced rapid, fatal neurotoxicity because of CAR recognition of GD2 | [
0.03570399805903435,
0.02385634556412697,
0.057282835245132446,
0.07232820242643356,
-0.03846461698412895,
-0.04488305747509003,
0.012629829347133636,
0.004790823440998793,
-0.02995271049439907,
-0.005112895742058754,
-0.020934689790010452,
-0.011813146993517876,
-0.035934049636125565,
0.016092104837298393,
0.0145047502592206,
-0.06018148362636566,
0.07324840873479843,
-0.03995995223522186,
0.03402462229132652,
0.013584543950855732,
0.02277510240674019,
0.021233757957816124,
-0.0019194926135241985,
0.01809355430305004,
0.002278948202729225,
-0.0018677309853956103,
0.053325947374105453,
0.001256656600162387,
0.008189834654331207,
-0.012514803558588028,
0.019312826916575432,
-0.013043922372162342,
-0.03455374017357826,
-0.05691475048661232,
-0.02075064927339554,
0.01849614456295967,
0.016402674838900566,
0.043111659586429596,
-0.0593072883784771,
-0.022867122665047646,
0.032575298100709915,
0.008937502279877663,
0.008172580972313881,
0.08962807804346085,
-0.03538192808628082,
-0.002976291812956333,
-0.003151706187054515,
-0.04143228381872177,
0.007591701112687588,
0.013653558678925037,
-0.002938908524811268,
0.00060280691832304,
-0.017311379313468933,
0.037843480706214905,
-0.05682273209095001,
0.035266902297735214,
-0.033104415982961655,
0.036348145455121994,
-0.008741958998143673,
0.032966386526823044,
0.012882886454463005,
-0.01995697058737278,
-0.0038706171326339245,
-0.027859242632985115,
-0.03174711391329765,
-0.02482256107032299,
-0.03793549910187721,
-0.03255229443311691,
-0.0013867794768884778,
0.022176967933773994,
-0.018680185079574585,
-0.03246027231216431,
0.01557448972016573,
-0.022499041631817818,
0.03439270704984665,
0.02942359261214733,
0.03144804760813713,
0.032575298100709915,
0.031056959182024002,
-0.009794444777071476,
0.02873343788087368,
-0.008753460831940174,
-0.0034622757229954004,
-0.041363269090652466,
-0.03995995223522186,
-0.029216546565294266,
-0.009483874775469303,
-0.05042729899287224,
-0.03436969965696335,
0.020693136379122734,
0.002332147443667054,
0.012434286065399647,
-0.039200782775878906,
0.032299235463142395,
-0.03979891538619995,
0.005455097183585167,
-0.0028655794449150562,
-0.06423038989305496,
0.01888723112642765,
0.0077642397955060005,
-0.009938227012753487,
0.002842574380338192,
-0.03708430752158165,
-0.016506198793649673,
0.0236032884567976,
0.0005478102248162031,
-0.05378605052828789,
0.004244450945407152,
0.022878626361489296,
-0.029998721554875374,
0.10573168843984604,
-0.020865675061941147,
-0.03213820233941078,
0.064736507833004,
0.0017282621702179313,
-0.04529714956879616,
-0.05829505994915962,
0.021015208214521408,
0.01996847428381443,
0.03680824860930443,
-0.005541366524994373,
0.007373151835054159,
0.02857240103185177,
-0.04840284585952759,
-0.004638414364308119,
0.0024701785296201706,
0.05691475048661232,
0.010007241740822792,
-0.03292037546634674,
-0.03653218597173691,
0.03616410121321678,
-0.02010650560259819,
0.015252416953444481,
-0.021912408992648125,
-0.03061985969543457,
0.006027350202202797,
-0.025558726862072945,
-0.03726835176348686,
-0.05553444102406502,
0.0256047360599041,
0.010404081083834171,
-0.009386102668941021,
0.0038476120680570602,
0.019611893221735954,
-0.031908150762319565,
-0.02050909586250782,
-0.019220806658267975,
0.02979167550802231,
-0.0033012395724654198,
0.03209219127893448,
-0.028158308938145638,
0.06929152458906174,
0.08576321601867676,
-0.024477483704686165,
-0.0013918118784204125,
-0.03625612333416939,
-0.0015097132418304682,
0.05581050366163254,
-0.016529202461242676,
-0.05350998789072037,
-0.015977079048752785,
0.009759936481714249,
-0.015758531168103218,
-0.017518425360322,
-0.00478794751688838,
0.01971541717648506,
-0.026939036324620247,
0.03117198497056961,
-0.04251352697610855,
-0.00855216570198536,
-0.02992970496416092,
-0.018266092985868454,
-0.07504281401634216,
-0.015424955636262894,
-0.055350400507450104,
-0.006113619543612003,
0.01133003830909729,
0.02657095342874527,
-0.0101222675293684,
-0.012261747382581234,
0.013469518162310123,
0.007286882493644953,
0.03275933861732483,
-0.011893664486706257,
-0.014573764987289906,
0.0037153323646634817,
-0.026248881593346596,
0.010415583848953247,
-0.046585436910390854,
-0.0009324276470579207,
0.045412175357341766,
-0.00509564159438014,
0.08718953281641006,
-0.007603203412145376,
0.003404762828722596,
-0.05222170054912567,
0.027077065780758858,
0.030458824709057808,
-0.020854173228144646,
-0.01833510771393776,
0.025006603449583054,
-0.059675369411706924,
-0.03667021542787552,
0.014642780646681786,
-0.04272057116031647,
-0.005049631465226412,
-0.019646402448415756,
0.02845737524330616,
0.006648489739745855,
0.015747027471661568,
0.04354875534772873,
-0.0009007955668494105,
-0.020198525860905647,
0.0053343200124800205,
0.009466621093451977,
-0.01543645840138197,
0.01099646370857954,
0.02279810793697834,
0.03524389490485191,
0.0012092083925381303,
-0.022901631891727448,
0.002874206518754363,
-0.021521322429180145,
0.05056532844901085,
-0.05277382582426071,
0.005616133101284504,
0.026524942368268967,
-0.022476036101579666,
0.004606781993061304,
-0.015470966696739197,
-0.022073445841670036,
-0.002670035697519779,
0.03901674225926399,
-0.05484428629279137,
-0.04506709799170494,
-0.005268180277198553,
0.056868743151426315,
0.03321944177150726,
0.06087163835763931,
-0.015263919718563557,
0.007488177623599768,
0.029883695766329765,
0.033633533865213394,
-0.022855620831251144,
-0.03384058177471161,
-0.04191539064049721,
-0.016368167474865913,
-0.041202232241630554,
0.018300600349903107,
-0.009949728846549988,
-0.031125973910093307,
0.04226046800613403,
0.009581646881997585,
0.0032753588166087866,
0.0033041152637451887,
-0.0029173411894589663,
0.047390617430210114,
-0.016563711687922478,
0.015724023804068565,
-0.04088015854358673,
0.02535168081521988,
0.030964937061071396,
-0.03650917857885361,
-0.07122395932674408,
-0.04393984377384186,
-0.005998594220727682,
-0.01132428739219904,
-0.004227197263389826,
0.021889403462409973,
0.032046180218458176,
0.04163932800292969,
-0.015965577214956284,
0.0242704376578331,
-0.034990839660167694,
-0.06510458886623383,
-0.007091338746249676,
-0.03671622648835182,
0.05249776318669319,
0.0064414432272315025,
0.005851936060935259,
-0.002836822997778654,
0.023557277396321297,
0.011893664486706257,
-0.04927704110741615,
-0.018864227458834648,
-0.011076982133090496,
-0.011422059498727322,
0.007436416111886501,
-0.0161956287920475,
-0.01846163719892502,
0.0029087141156196594,
0.005690900143235922,
-0.02213095873594284,
-0.0031258254311978817,
-0.042030416429042816,
0.005656392313539982,
-0.016483193263411522,
0.005179035477340221,
-0.035036850720644,
-0.02376432530581951,
-0.04090316593647003,
0.016655731946229935,
-0.025811783969402313,
-0.014884334988892078,
-0.005857687443494797,
0.009288331493735313,
-0.010473096743226051,
-0.018956247717142105,
0.03075789101421833,
0.036095086485147476,
0.004635538440197706,
-0.05235973000526428,
0.03287436440587044,
0.04246751591563225,
0.009035274386405945,
0.009725429117679596,
-0.006470199674367905,
-0.04734460636973381,
0.03874067962169647,
-0.014159672893583775,
-0.04246751591563225,
-0.0290095005184412,
-0.015286925248801708,
-0.0023767200764268637,
0.02979167550802231,
-0.0101222675293684,
0.013619051314890385,
-0.005987091455608606,
0.04771269112825394,
-0.041731350123882294,
0.03436969965696335,
-0.025857793167233467,
0.03860265016555786,
0.005276807118207216,
0.017886508256196976,
-0.046056319028139114,
-0.008851232938468456,
-0.030711881816387177,
0.015056873671710491,
0.0026067716535180807,
0.013722574338316917,
0.01767946034669876,
-0.014918842352926731,
0.026064839214086533,
-0.008603927679359913,
0.004048907198011875,
-0.007430664729326963,
0.021130234003067017,
0.009593149647116661,
-0.004080539103597403,
-0.004526264034211636,
0.0018849847838282585,
-0.0391547717154026,
0.015528479591012001,
-0.03841860592365265,
0.030711881816387177,
-0.02401738055050373,
0.009225066751241684,
0.024086397141218185,
0.016667233780026436,
0.01565500721335411,
0.011554338969290257,
-0.03926979750394821,
0.033725555986166,
0.05696076154708862,
0.0593532994389534,
-0.03791249543428421,
0.037728454917669296,
-0.02981467917561531,
-0.01280236802995205,
-0.039039745926856995,
-0.035796020179986954,
0.018921740353107452,
-0.00584043376147747,
-0.048632897436618805,
0.031885143369436264,
0.012641332112252712,
0.010461593978106976,
0.02132577821612358,
-0.024063391610980034,
0.03200016915798187,
-0.019485365599393845,
0.00394250825047493,
-0.021015208214521408,
-0.014884334988892078,
0.003341498551890254,
0.03278234601020813,
-0.025696758180856705,
-0.08042602241039276,
-0.01738039404153824,
0.005204916000366211,
-0.02429344318807125,
-0.008724704384803772,
0.037015292793512344,
-0.0057656667195260525,
0.06648489832878113,
0.007936778478324413,
0.05231372267007828,
0.03250628337264061,
0.020002981647849083,
0.004902973305433989,
-0.017564434558153152,
0.0011905167484655976,
-0.04074212908744812,
0.021797383204102516,
-0.004503258969634771,
0.035404931753873825,
0.03660120069980621,
0.010197035036981106,
-0.047160565853118896,
0.01051335595548153,
0.024845566600561142,
0.016230136156082153,
0.027583179995417595,
0.021958420053124428,
-0.03816555067896843,
-0.027859242632985115,
0.032575298100709915,
-0.02362629398703575,
0.030665870755910873,
0.046493418514728546,
-0.022717589512467384,
-0.00293315714225173,
-0.015229412354528904,
-0.024385463446378708,
-0.0026283389888703823,
0.014780811965465546,
0.028641417622566223,
0.012549311853945255,
-0.05732884630560875,
-0.029515612870454788,
0.04697652533650398,
0.002064712578430772,
-0.007010820787400007,
-0.0002706700179260224,
0.01671324484050274,
-0.009196310304105282,
0.01011651661247015,
-0.0458492711186409,
0.018691688776016235,
-0.025259658694267273,
-0.015263919718563557,
0.004701678641140461,
-0.001399000990204513,
0.02956162393093109,
0.0036405655555427074,
0.006165381520986557,
0.0016348038334399462,
0.003971264697611332,
-0.01767946034669876,
-0.022591061890125275,
0.00031578168272972107,
-0.002169673563912511,
-0.01287138368934393,
-0.02454650029540062,
-0.023902354761958122,
0.04617134481668472,
-0.04973714426159859,
-0.0007397594745270908,
0.03549695387482643,
0.043364714831113815,
-0.025673752650618553,
-0.008529161103069782,
-0.022706087678670883,
0.0011639170115813613,
0.02776722051203251,
0.06308013200759888,
-0.004529139958322048,
0.038648657500743866,
-0.018185574561357498,
-0.02106121927499771,
0.012779363431036472,
0.01726536825299263,
0.005895070731639862,
-0.017449408769607544,
0.03749840334057808,
0.014355216175317764,
0.0151718994602561,
0.02239551767706871,
0.01085843238979578,
-0.024109400808811188,
0.024983597919344902,
-0.007977037690579891,
-0.03800451382994652,
0.027353128418326378,
0.04927704110741615,
-0.02196992188692093,
0.00035999470856040716,
-0.02914752997457981,
0.03225322812795639,
-0.0051042684353888035,
0.002731862012296915,
0.00923656951636076,
-0.010133770294487476,
-0.03450773283839226,
0.02385634556412697,
0.026110850274562836,
-0.03436969965696335,
-0.010708899237215519,
-0.014918842352926731,
-0.011790141463279724,
0.004347973968833685,
0.022591061890125275,
0.006562220398336649,
0.03280534967780113,
0.01579303853213787,
0.004569398704916239,
0.04561921954154968,
-0.010984960943460464,
0.016356665641069412,
-0.019473863765597343,
-0.012445788830518723,
0.012618327513337135,
-0.010576619766652584,
-0.0444689616560936,
-0.040005963295698166,
-0.03699228912591934,
0.003850487759336829,
-0.010220039635896683,
0.03708430752158165,
-0.011985685676336288,
-0.03287436440587044,
-0.02873343788087368,
0.01342350710183382,
0.009432113729417324,
-0.010611127130687237,
-0.03517488017678261,
-0.03708430752158165,
-0.03793549910187721,
-0.024178417399525642,
0.04117922484874725,
-0.015954075381159782,
0.0012293378822505474,
-0.0035370425321161747,
-0.04927704110741615,
-0.004132300615310669,
-0.03227623179554939,
0.024247432127594948,
-0.02643292210996151,
-0.030849911272525787,
0.010680142790079117,
-0.0061768838204443455,
0.03195415809750557,
-0.019128786399960518,
0.00024856350501067936,
-0.0051186466589570045,
-0.008672943338751793,
-0.01065713819116354,
0.03117198497056961,
-0.0016276147216558456,
0.041754353791475296,
-0.02282111346721649,
0.0276521947234869,
-0.007706726901233196,
0.018772205337882042,
-0.02629489079117775,
-0.018933242186903954,
-0.003951135091483593,
-0.018933242186903954,
-0.009202062152326107,
-0.026939036324620247,
-0.03262130916118622,
0.011099986732006073,
-0.0296766497194767,
-0.0236032884567976,
0.002408351982012391,
0.0047965748235583305,
0.012986409477889538,
-0.027744216844439507,
0.005115771200507879,
-0.01139330305159092,
0.005524112842977047,
-0.01168086752295494,
0.022361010313034058,
0.05042729899287224,
-0.018381118774414062,
-0.011284028179943562,
0.027560174465179443,
0.0168742798268795,
-0.004612533375620842,
-0.033725555986166,
0.008471648208796978,
0.004204191733151674,
0.03158607706427574,
-0.01888723112642765,
0.03565799072384834,
-0.05544242262840271,
0.0014996485551819205,
-0.028434371575713158,
-0.04129425063729286,
0.0007843319908715785,
-0.012491798959672451,
0.043479740619659424,
0.00938035175204277,
-0.02240701951086521,
0.0050122481770813465,
0.008477399125695229,
-0.008822476491332054,
-0.02104971557855606,
-0.0009525571949779987,
0.012480296194553375,
-0.02049759216606617,
-0.008805222809314728,
-0.03361053019762039,
-0.024362457916140556,
0.030021727085113525,
-0.010484599508345127,
-0.018162569031119347,
0.007010820787400007,
0.0006419876008294523,
0.025558726862072945,
0.03423167020082474,
-0.03949984908103943,
0.002312018070369959,
0.02831934578716755,
-0.0032983641140162945,
-0.027031056582927704,
-0.008718953467905521,
0.01941635087132454,
-0.009006517939269543,
-0.016632726415991783,
-0.003755591344088316,
-0.017506921663880348,
-0.016506198793649673,
-0.013538532890379429,
-0.03448472544550896,
-0.014171174727380276,
0.006401184014976025,
-0.006332168821245432,
-0.01643718220293522,
-0.008655689656734467,
-0.03464576229453087,
0.007839006371796131,
0.012618327513337135,
0.0036693220026791096,
-0.0364631712436676,
-0.010018744505941868,
-0.03749840334057808,
-0.030389808118343353,
-0.013181953690946102,
-0.032575298100709915,
-0.01146806962788105,
0.010622629895806313,
-0.031056959182024002,
0.010553614236414433,
-0.013435009866952896,
-0.03602607175707817,
-0.015355940908193588,
0.01943935453891754,
0.011145996861159801,
0.0030913176015019417,
0.006061858031898737,
0.005345822777599096,
-0.038901716470718384,
-0.00390800042077899,
-0.024891577661037445,
-0.01382609736174345,
-0.03519788756966591,
0.049323052167892456,
0.07573296874761581,
-0.04785072058439255,
0.008161078207194805,
-0.018139563500881195,
-0.00619988888502121,
-0.000244609487708658,
0.0010115079348906875,
0.023902354761958122,
-0.009351595304906368,
-0.010795168578624725,
0.00359167973510921,
0.0729263424873352,
0.029216546565294266,
0.0049576107412576675,
-0.03349550440907478,
0.02845737524330616,
-0.004833958111703396,
0.013619051314890385,
-0.023108677938580513,
-0.021935414522886276,
-0.013780087232589722,
0.006562220398336649,
0.0028641417156904936,
-0.01369956973940134,
-0.0687854140996933,
0.007666467688977718,
-0.0018217206234112382,
0.007327141705900431,
0.001236526994034648,
0.01275635790079832,
-0.008460145443677902,
-0.00145795161370188,
-0.026916030794382095,
-0.020428577437996864,
-0.0017699591116979718,
0.00950112845748663,
0.043893832713365555,
-0.002048896625638008,
-0.008707450702786446,
-0.0263178963214159,
0.009558641351759434,
0.00828760676085949,
0.010691645555198193,
0.03411664441227913,
-0.011410556733608246,
0.018519150093197823,
-0.007407659664750099,
0.01422868762165308,
-0.012031695805490017,
0.04117922484874725,
0.031217994168400764,
0.027951262891292572,
0.006941805128008127,
-0.02696203999221325,
-0.006424189545214176,
-0.0118016442283988,
0.010869935154914856,
0.006332168821245432,
0.03975290805101395,
-0.0026959164533764124,
0.02861841209232807,
-0.01632215641438961,
0.012411280535161495,
-0.02413240633904934,
0.026363907381892204,
-0.0026053336914628744,
0.007700975518673658,
-0.02535168081521988,
0.04734460636973381,
-0.022015932947397232,
-0.02196992188692093,
0.0111172404140234,
-0.015758531168103218,
-0.054154131561517715,
-0.0004619003739207983,
-0.00553273968398571,
0.01644868589937687,
0.002142355078831315,
-0.00584043376147747,
-0.017851999029517174,
-0.006861287169158459,
0.04676947742700577,
-0.008264601230621338,
-0.03749840334057808,
-0.015539981424808502,
-0.0003107493103016168,
0.056868743151426315,
-0.009478123858571053,
-0.006349422503262758,
-0.00570240244269371,
-0.019255314022302628,
0.002868455136194825,
0.007240872364491224,
-0.016161121428012848,
-0.011761385016143322,
-0.0016204256098717451,
-0.024178417399525642,
0.0015399075346067548,
0.028227323666214943,
-0.014240190386772156,
-0.030849911272525787,
-0.0161956287920475,
0.007522685453295708,
-0.0229361392557621,
0.007396156899631023,
0.022832615301012993,
0.002414103364571929,
-0.004000021144747734,
0.026916030794382095,
-0.012319260276854038,
0.008598176762461662,
-0.014079154469072819,
-0.014044647105038166,
0.014585267752408981,
-0.012882886454463005,
-0.017748476937413216,
0.012434286065399647,
-0.043640777468681335,
-0.01859966665506363,
-0.005213543307036161,
0.021774377673864365,
-0.007994291372597218,
-0.0068037742748856544,
-0.017886508256196976,
0.02523665502667427,
-0.008419886231422424,
-0.022844118997454643,
-0.014723299071192741,
0.03885570541024208,
-0.0202330332249403,
0.005078387912362814,
-0.03165509179234505,
0.020014483481645584,
-0.025029607117176056,
0.021394792944192886,
0.028089294210076332,
0.04058109223842621,
0.05180760845541954,
-0.10315511375665665,
-0.022061942145228386,
-0.002754867309704423,
0.003979891538619995,
-0.009299833327531815,
0.010179780423641205,
0.006228645332157612,
-0.0028641417156904936,
0.02588079869747162,
-0.02401738055050373,
-0.021291270852088928,
-0.006194137968122959,
0.0022530672140419483,
0.025006603449583054,
0.021475311368703842,
-0.022303497418761253,
-0.003620436182245612,
-0.008327865973114967,
-0.03287436440587044,
0.016299152746796608,
0.02321220003068447,
0.011985685676336288,
0.01994546875357628,
0.04532015323638916,
0.0016419929452240467,
0.014930345118045807,
-0.0256047360599041,
-0.03667021542787552,
-0.018392620608210564,
-0.03627912700176239,
0.030964937061071396,
0.015206406824290752,
-0.01701231114566326,
0.06041153520345688,
-0.026939036324620247,
-0.034990839660167694,
0.051991648972034454,
-0.02979167550802231,
0.005621884483844042,
0.021958420053124428,
0.03761342912912369,
-0.004810953047126532,
0.046332381665706635,
0.01643718220293522,
-0.013147445395588875,
-0.01593106985092163,
-0.05553444102406502,
-0.025811783969402313,
-0.0016204256098717451,
-0.013619051314890385,
0.03227623179554939,
-0.012813870795071125,
-0.06400033831596375,
-0.014010138809680939,
-0.003528415458276868,
-0.006608230527490377,
0.029860690236091614,
0.013929621316492558,
0.013481019996106625,
0.0024299193173646927,
-0.027330122888088226,
0.037705447524785995,
0.010536360554397106,
-0.02333872951567173,
0.010634132660925388,
-0.010024496354162693,
-0.015724023804068565,
0.007488177623599768,
-0.03133302181959152,
0.033518508076667786,
-0.013515528291463852,
0.0036491926293820143,
-0.03301239758729935,
0.03142504021525383,
0.002904400695115328,
0.03618710860610008,
-0.011456566862761974,
0.003571550128981471,
0.009460870176553726,
0.0256047360599041,
-0.02953861840069294,
0.02331572398543358,
-0.03761342912912369,
0.0208886805921793,
-0.025949813425540924,
0.01846163719892502,
0.01187065988779068,
0.012813870795071125,
-0.022763600572943687,
-0.010030247271060944,
0.0010007242672145367,
-0.015470966696739197,
-0.006424189545214176,
0.04288160800933838,
0.004376730415970087,
-0.02224598452448845,
-0.03848762437701225,
0.004034528974443674,
0.002618274185806513,
-0.02670898474752903,
0.05705278366804123,
-0.05608656629920006,
-0.008442891761660576,
-0.002754867309704423,
-0.028365354984998703,
-0.025006603449583054,
0.03287436440587044,
0.0027117326389998198,
0.004425616469234228,
-0.0229476410895586,
0.021245259791612625,
0.014803816564381123,
0.01780598983168602,
-0.02332722581923008,
-0.009207813069224358,
0.02387935109436512,
-0.0072523751296103,
-0.04460699483752251,
0.012100711464881897,
-0.004060409963130951,
0.03287436440587044,
-0.009150300174951553,
0.01476930920034647,
0.006429940462112427,
-0.026225876063108444,
0.008879989385604858,
0.02303966134786606,
0.02266007661819458,
0.015850551426410675,
0.0014881459064781666,
0.018266092985868454,
-0.007321390323340893,
0.01980743743479252,
-0.0057656667195260525,
0.009949728846549988,
0.03683125227689743,
0.016897285357117653,
0.02496059238910675,
-0.026801005005836487,
0.03303540125489235,
0.027353128418326378,
-0.030596856027841568,
-0.02629489079117775,
-0.03952285647392273,
0.012652834877371788,
-0.014044647105038166,
-0.040535081177949905,
0.004025902133435011,
0.016276147216558456,
-0.0040862904861569405,
-0.03710731491446495,
0.008402632549405098,
0.04927704110741615,
0.03117198497056961,
0.027560174465179443,
0.027744216844439507,
0.013469518162310123,
-0.01724236272275448,
-0.043226685374975204,
0.005998594220727682,
-0.017851999029517174,
0.03292037546634674,
-0.05300387740135193,
-0.014090657234191895,
0.004868465941399336,
-0.009173305705189705,
-0.006763515528291464,
0.034599751234054565,
0.020313551649451256,
0.006665743421763182,
-0.006982064340263605,
-0.0660247951745987,
0.044975075870752335,
0.007085587363690138,
-0.018956247717142105,
0.034622758626937866,
0.01403314433991909,
0.010760661214590073,
0.030803902074694633,
0.03301239758729935,
-0.03246027231216431,
-0.015045370906591415,
0.02196992188692093,
0.021693861111998558,
0.014079154469072819,
-0.006165381520986557,
-0.011824649758636951,
-0.07131598144769669,
0.011715374886989594,
-0.0022257487289607525,
-0.01984194479882717,
-0.01092744804918766,
-0.02668597921729088,
0.03549695387482643,
0.05999744310975075,
-0.027422143146395683,
-0.03140203654766083,
-0.005469475407153368,
-0.005665019154548645,
-0.04306564852595329,
-0.015068376436829567,
0.015988582745194435,
0.026870019733905792,
-0.036877263337373734,
-0.017322881147265434,
0.011824649758636951,
0.024040386080741882,
-0.030136752873659134,
-0.010409832000732422,
0.030527839437127113,
-0.008339368738234043,
0.0431346632540226,
-0.027077065780758858,
0.00532856909558177,
0.00751693407073617,
0.040397051721811295,
0.03073488548398018,
0.02159033715724945,
-0.021475311368703842,
-0.019634898751974106,
-0.03292037546634674,
-0.01873769797384739,
0.02307417057454586,
-0.015608997084200382,
-0.007850509136915207,
0.0030165507923811674,
0.011019469238817692,
0.012261747382581234,
0.00024047575425356627,
0.011422059498727322,
0.0030194264836609364,
0.02116474136710167,
0.008115068078041077,
0.0014097846578806639,
-0.01983044296503067,
0.01543645840138197,
-0.004793698899447918,
-0.007488177623599768,
0.013665061444044113,
0.02130277268588543,
0.01724236272275448,
-0.02399437688291073,
0.026087844744324684,
-0.041616324335336685,
-0.022878626361489296,
0.008874238468706608,
0.029584627598524094,
-0.018197076395154,
-0.01942785270512104,
0.009886465035378933,
-0.008609678596258163,
-0.001571539556607604,
0.024914581328630447,
0.025144632905721664,
0.019761428236961365,
0.00553273968398571,
0.005941081326454878,
0.010697396472096443,
0.020727643743157387,
0.0027591807302087545,
-0.003209219081327319,
0.002567950403317809,
-0.035013843327760696,
0.003422016743570566,
0.034185659140348434,
-0.03200016915798187,
-0.00022322188306134194,
-0.01980743743479252,
0.022038938477635384,
0.024914581328630447,
0.03321944177150726,
0.011893664486706257,
-0.031770117580890656,
0.0002280745393363759,
-0.010743407532572746,
-0.029745664447546005,
0.01644868589937687,
-0.00013946874241810292,
0.013262471184134483,
-0.020440079271793365,
-0.010576619766652584,
-0.018047543242573738,
-0.04380181431770325,
-0.00259958254173398,
0.015735525637865067,
-0.0022027434315532446,
0.0023738443851470947,
-0.02185489609837532,
0.0009180494234897196,
-0.019335832446813583,
-0.016241639852523804,
-0.02240701951086521,
0.011042473837733269,
-0.02861841209232807,
-0.001259532175026834,
-0.02804328314960003,
-0.009213563986122608,
0.007591701112687588,
0.005167532712221146,
-0.022303497418761253,
-0.0053544496186077595,
0.0134925227612257,
-0.002751991618424654,
-0.061837855726480484,
0.020842669531702995,
-0.020934689790010452,
-0.01807054877281189,
-0.028917478397488594,
0.05153154581785202,
-0.004198440816253424,
0.010846930555999279,
0.029101520776748657,
0.027882246300578117,
-0.022349506616592407,
0.020716141909360886,
0.06275805830955505,
-0.021555829793214798,
0.0017038192600011826,
0.006182635203003883,
0.027169087901711464,
-0.031125973910093307,
0.005797299090772867,
0.008736207149922848,
-0.012434286065399647,
-0.017069824039936066,
0.01463127788156271,
-0.005918075796216726,
-0.005794423166662455,
-0.010093511082231998,
-0.025972818955779076,
0.034599751234054565,
-0.023649299517273903,
0.01476930920034647,
0.020313551649451256,
-0.00020363155636005104,
-0.004983491729944944,
-0.010904443450272083,
-0.026754993945360184,
-0.0012861319119110703,
-0.004408362787216902,
-0.01887572929263115,
-0.01710433140397072,
0.009345844388008118,
0.0067980228923261166,
0.01970391534268856,
0.002856952603906393,
-0.017207855358719826,
-0.006067609414458275,
-0.005066885147243738,
0.005782920867204666,
0.046194348484277725,
-0.039177779108285904,
-0.042973630130290985,
0.06367826461791992,
-0.007511182688176632,
0.0215673316270113,
-0.014585267752408981,
0.027169087901711464,
0.00924232043325901,
-0.00418118666857481,
-0.004060409963130951,
0.005575874354690313,
0.012986409477889538,
-0.012330763041973114,
0.008701699785888195,
0.04117922484874725,
-0.043893832713365555,
-0.004399735946208239,
-0.0056535168550908566,
0.01766795851290226,
-0.0010251671774312854,
0.02537468448281288,
-0.042559534311294556,
0.005414837971329689,
0.021222254261374474,
0.03227623179554939,
0.06013547256588936,
-0.00583180645480752,
0.00971967726945877,
0.02239551767706871,
0.002859828295186162,
-0.032299235463142395,
-0.003968389239162207,
-0.01930132508277893,
-0.006556469015777111,
-0.00623439671471715,
-0.04168533906340599,
-0.031356025487184525,
-0.015022365376353264,
0.012181228958070278,
-0.0256047360599041,
0.0003889309009537101,
0.00795403216034174,
-0.012618327513337135,
-0.03211519494652748,
-0.016126614063978195,
0.014171174727380276,
-0.019094277173280716,
-0.022142460569739342,
0.020451582968235016,
-0.009144549258053303,
-0.013331486843526363,
0.00835662242025137,
-0.007022323552519083,
0.011916670016944408,
0.030688876286149025,
-0.003815979929640889,
0.008517658337950706,
0.027215097099542618,
0.008304860442876816,
-0.011824649758636951,
-0.015608997084200382,
-0.05489029735326767,
0.018047543242573738,
-0.02979167550802231,
0.009104290045797825,
-0.020463084802031517,
-0.01981894113123417,
-0.030573850497603416,
-0.02884846366941929,
0.015298428013920784,
-0.007177608087658882,
0.013688066974282265,
-0.02118774689733982,
-0.010053252801299095,
0.02171686477959156,
0.01503386814147234,
0.011427810415625572,
-0.06487453728914261,
0.03786648437380791,
0.008805222809314728,
-0.01356153842061758,
0.03558897227048874,
-0.03282835707068443,
-0.007511182688176632,
0.010812422260642052,
-0.013998636044561863,
0.01463127788156271,
-0.01728837378323078,
-0.006775017827749252,
0.0022401269525289536,
-0.013170450925827026,
0.019991479814052582,
0.013124440796673298,
0.016161121428012848,
-0.034346695989370346,
0.005440718960016966,
-0.007718229200690985,
0.0017685212660580873,
0.01994546875357628,
0.021624844521284103,
0.026478933170437813,
-0.037176329642534256,
-0.033127423375844955,
-0.025535721331834793,
0.02696203999221325,
-0.02588079869747162,
-0.0003253072500228882,
0.00039935510721988976,
0.010685894638299942,
-0.015217909589409828,
-0.0003431003133300692,
0.0013199207605794072,
0.012629829347133636,
-0.003361628158017993,
0.007689472753554583,
-0.015148893930017948,
-0.016931792721152306,
-0.02751416526734829,
-0.01275635790079832,
0.009340092539787292,
0.012043198570609093,
0.02307417057454586,
0.001790088601410389,
0.03894772753119469,
-0.013975631445646286,
0.028963489457964897,
0.03572700545191765,
0.01846163719892502,
-0.0145047502592206,
-0.03319643810391426,
0.006970561575144529,
0.015942571684718132,
-0.01688578352332115,
0.008172580972313881,
0.02454650029540062,
0.004983491729944944,
-0.006924551445990801,
0.036739230155944824,
-0.0021179120521992445,
0.009535636752843857,
-0.013273973949253559,
-0.024776551872491837,
0.02429344318807125,
-0.011485323309898376,
-0.0030826907604932785,
0.022579558193683624,
-0.015735525637865067,
-0.010306308977305889,
-0.02576577290892601,
-0.013262471184134483,
0.014171174727380276,
-0.013101435266435146,
-0.019749924540519714,
-0.001290445332415402,
-0.008051804266870022,
-0.02282111346721649,
-0.04518212378025055,
-0.0023910982999950647,
0.007723980583250523,
-0.03699228912591934,
-0.0023220828734338284,
0.01579303853213787,
0.01563200168311596,
0.037291355431079865,
-0.023154687136411667,
0.0016376794083043933,
0.03561197966337204,
0.0249375868588686,
-0.01550547406077385,
0.018001534044742584,
0.02305116504430771,
0.0377974696457386,
-0.01363055408000946,
0.0007879265467636287,
-0.015528479591012001,
0.014654283411800861,
-0.00938035175204277,
-0.005610382184386253,
0.03933881223201752,
0.04124824330210686,
-0.015620499849319458,
0.011824649758636951,
-0.01410215999931097,
-0.021647850051522255,
0.06579474359750748,
0.0022875750437378883,
-0.009765688329935074,
-0.01698930561542511,
-0.003965513315051794,
-0.025029607117176056,
0.0013342989841476083,
0.02362629398703575,
-0.02992970496416092,
-0.0013659310061484575,
0.010869935154914856,
0.023810334503650665,
-0.012146721594035625,
-0.029584627598524094,
0.027560174465179443,
0.029377581551671028,
-0.01099071279168129,
0.0009367411257699132,
-0.010869935154914856,
0.00006407294858945534,
-0.019519872963428497,
-0.0015758530935272574,
-0.0030798150692135096,
-0.032690323889255524,
-0.022464532405138016,
0.017840497195720673,
0.017748476937413216,
0.03301239758729935,
0.037015292793512344,
-0.011974182911217213,
-0.01807054877281189,
0.011111489497125149,
-0.01738039404153824,
0.007378903217613697,
-0.005673645995557308,
0.005253802053630352,
-0.03722234070301056,
-0.006125122308731079,
-0.004293336998671293,
-0.04131725803017616,
0.0222344808280468,
0.006355173885822296,
0.012572316452860832,
0.001375995809212327,
0.009127294644713402,
-0.02196992188692093,
0.007309887558221817,
-0.011997188441455364,
-0.00296766497194767,
0.0028210070449858904,
-0.04354875534772873,
-0.052267711609601974,
0.010283304378390312,
-0.008914497680962086,
-0.012917393818497658,
-0.052267711609601974,
0.005222170148044825,
0.009627657011151314,
0.008201337419450283,
-0.01557448972016573,
0.012296254746615887,
-0.0069993180222809315,
-0.019450858235359192,
-0.022418523207306862,
-0.005725407972931862,
-0.0066369869746267796,
0.016264643520116806,
-0.007447918877005577,
-0.0377514585852623,
-0.0022516294848173857,
0.002731862012296915,
-0.013527031056582928,
-0.007643462624400854,
0.00619988888502121,
-0.0017685212660580873,
-0.023810334503650665,
0.002524815732613206,
-0.009121543727815151,
0.007321390323340893,
0.019991479814052582,
0.010415583848953247,
-0.026340901851654053,
-0.01125527173280716,
0.014619775116443634,
0.009414859116077423,
0.03616410121321678,
0.06059557572007179,
0.0035169129259884357,
0.00010001850023400038,
-0.005768542643636465,
-0.006291909608989954,
-0.021647850051522255,
0.036095086485147476,
0.03545094281435013,
0.009874962270259857,
0.006314914673566818,
0.011577343568205833,
0.010012993589043617,
-0.04607932269573212,
0.028434371575713158,
-0.014608273282647133,
-0.012089208699762821,
0.006458696909248829,
-0.029584627598524094,
0.015344438143074512,
-0.021256763488054276,
0.004724683705717325,
-0.0003954010899178684,
0.010697396472096443,
-0.03172410652041435,
0.03558897227048874,
-0.030435819178819656,
0.015585992485284805,
0.023787328973412514,
-0.013803092762827873,
-0.0019453733693808317,
0.011617602780461311,
0.03358752653002739,
-0.01342350710183382,
0.01187065988779068,
-0.00037347429315559566,
0.0030625611543655396,
0.0038303581532090902,
-0.0005539209814742208,
-0.00850615557283163,
0.009138797409832478,
0.003603182267397642,
-0.008471648208796978,
0.03303540125489235,
-0.001591669162735343,
0.00829335767775774,
0.022752096876502037,
0.02454650029540062,
0.001032356289215386,
-0.0009223629022017121,
-0.02979167550802231,
0.005291185341775417,
-0.02280960977077484,
-0.006976312957704067,
0.1266203671693802,
0.004785072058439255,
-0.014677288010716438,
0.009058279916644096,
0.01809355430305004,
-0.020187022164463997,
0.02712307684123516,
-0.016138115897774696,
0.016908789053559303,
-0.0007225056178867817,
0.02322370372712612,
0.0004083414969500154,
0.036762237548828125,
0.03455374017357826,
0.013538532890379429,
-0.016931792721152306,
-0.015747027471661568,
0.03158607706427574,
-0.02926255576312542,
-0.008299109525978565,
0.009294082410633564,
-0.012733353301882744,
-0.00322359730489552,
0.01727687008678913,
-0.03009074181318283,
-0.01660972088575363,
-0.01997997611761093,
-0.042007412761449814,
-0.02102671191096306,
-0.02696203999221325,
0.02037106454372406,
0.0039022492710500956,
-0.0055701229721307755,
-0.01294039934873581,
0.006987815722823143,
-0.034990839660167694,
-0.01795552298426628,
-0.04290461167693138,
0.007505431771278381,
-0.004882844164967537,
0.014090657234191895,
-0.001001443131826818,
-0.0015542857581749558,
0.012376773171126842,
0.04352575168013573,
0.00809781439602375,
-0.01382609736174345,
0.013170450925827026,
0.00448888074606657,
-0.03126400336623192,
0.00283107184804976,
-0.008678694255650043,
0.008949005044996738,
-0.025190643966197968,
-0.014918842352926731,
-0.010800919495522976,
-0.006867038551717997,
0.016816766932606697,
-0.015332935377955437,
-0.05433817580342293,
-0.03738337755203247,
0.011997188441455364,
0.027629191055893898,
-0.014619775116443634,
0.01646018773317337
] | 2025-01-22 | 1 | 39841845 | [
"CAR T cells",
"tumor antigens",
"T cell therapy",
"chimeric antigen receptor",
"solid tumors",
"CAR recognition",
"GD2",
"normal tissues",
"CAR",
"rapid, fatal neurotoxicity",
"A major limiting factor",
"the success",
"the treatment"
] | [] | 0 | 10.1126/sciadv.ads3403 | [
"Vogt",
"Silberman",
"Lin",
"Han",
"Laflin",
"Gellineau",
"Heller",
"Scheinberg"
] | [
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.\nGraduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.\nTri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.\nGraduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.\nPharmacology Program, Weill Cornell Medicine, New York, NY 10065, USA.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.\nGraduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.\nBCMB Program, Weill Cornell Medicine, New York, NY 10065, USA.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.",
"Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.\nGraduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.\nTri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.\nPharmacology Program, Weill Cornell Medicine, New York, NY 10065, USA.",
"Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.\nGraduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.\nTri-Institutional PhD Program in Chemical Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.\nPharmacology Program, Weill Cornell Medicine, New York, NY 10065, USA."
] | [
"39841845"
] | [] | 9.616429 | 6.79694 |
39841806 | 5 | Triple knockdown of | Chimeric antigen receptor (CAR)-T cell therapies have revolutionized the landscape of cancer treatment, in particular in the context of hematologic malignancies. However, for solid tumors that lack tumor-specific antigens, CAR-T cells can infiltrate and attack nonmalignant tissues expressing the CAR target antigen, leading to on-target, off-tumor toxicity. Severe on-target, off-tumor toxicities have been observed in clinical trials of CAR-T therapy for solid tumors, highlighting the need to address this issue. Here, we demonstrated that targeting the cell adhesion and migration molecules lymphocyte function-associated antigen 1 (LFA-1; CD11a/CD18) and very late activation antigen 4 (VLA-4; CD49d/CD29) with blocking antibodies reduced the on-target, off-tumor toxicity of CAR-T cells in mice. To translate this observation into improved CAR-T cell therapy, we either knocked out both | [
0.013676300644874573,
0.025339338928461075,
0.047948043793439865,
0.07261629402637482,
-0.04267190769314766,
-0.04850342869758606,
-0.014960622414946556,
-0.00861421786248684,
-0.003343866905197501,
0.003502961015328765,
-0.005660854279994965,
-0.011269642040133476,
-0.04294959828257561,
-0.009227452799677849,
-0.011483695358037949,
-0.05424238368868828,
0.03952473774552345,
-0.030638614669442177,
0.02520049177110195,
0.022354155778884888,
0.006045572459697723,
0.016892891377210617,
0.006896002683788538,
-0.016927603632211685,
-0.0273294597864151,
-0.01874416694045067,
0.038182564079761505,
-0.028949325904250145,
-0.025617029517889023,
-0.019878074526786804,
0.05058611184358597,
-0.024136008694767952,
-0.025802157819271088,
-0.02855592966079712,
-0.002993860049173236,
0.03714122250676155,
0.040890056639909744,
0.008400164544582367,
-0.04239421710371971,
-0.035891611129045486,
0.011107655242085457,
0.04625875502824783,
0.025825297459959984,
0.07687422633171082,
-0.039779290556907654,
0.0074398149736225605,
-0.005597217008471489,
-0.03417918086051941,
-0.01263495720922947,
0.00047402785276062787,
-0.011807668954133987,
0.0039947060868144035,
-0.01924169808626175,
0.06798810511827469,
-0.06877489387989044,
0.03987185284495354,
-0.019195416942238808,
0.028879903256893158,
0.035845328122377396,
0.016395362094044685,
-0.020410316064953804,
-0.011963870376348495,
0.01730942912399769,
-0.028787339106202126,
-0.053779564797878265,
0.0020016920752823353,
-0.07493039220571518,
-0.050493549555540085,
0.0017659435980021954,
0.031703099608421326,
-0.013872998766601086,
-0.042486779391765594,
0.021312812343239784,
0.012588676065206528,
0.04308844357728958,
-0.007098485715687275,
0.008134042844176292,
0.03915448486804962,
0.0071563380770385265,
-0.01106137316673994,
0.04463888704776764,
0.018686315044760704,
0.02248143032193184,
-0.05285392701625824,
-0.017841670662164688,
-0.002753772772848606,
-0.011871306225657463,
-0.04188511520624161,
-0.0509563684463501,
0.008301815018057823,
0.009551426395773888,
0.025431901216506958,
-0.022007040679454803,
0.02154422178864479,
-0.020549161359667778,
0.023974021896719933,
-0.008388593792915344,
-0.04780919849872589,
0.03487340733408928,
0.008411734364926815,
0.047369521111249924,
-0.009586137719452381,
-0.038136281073093414,
-0.05003073066473007,
0.03390149027109146,
-0.014208542183041573,
-0.03996441885828972,
-0.001966980518773198,
0.032605595886707306,
-0.0031124574597924948,
0.08677855134010315,
-0.016071388497948647,
-0.021185537800192833,
0.06437812000513077,
-0.0183044895529747,
-0.06868233531713486,
-0.049012526869773865,
0.020861564204096794,
-0.007995197549462318,
0.0034306454472243786,
-0.00370255159214139,
0.02220373973250389,
0.04961419105529785,
-0.03110143356025219,
0.012958930805325508,
-0.023326074704527855,
0.07423616200685501,
-0.0030603904742747545,
-0.04919765517115593,
-0.05215969681739807,
0.05401097238063812,
0.006901787593960762,
0.019299549981951714,
0.016603630036115646,
-0.05026213824748993,
-0.01842019520699978,
0.004931914620101452,
0.01850118860602379,
-0.04929021745920181,
0.011067158542573452,
0.0017717288574203849,
0.008660499937832355,
0.012692810036242008,
-0.02297896146774292,
-0.027584010735154152,
-0.03517423942685127,
0.01933426223695278,
0.006172847934067249,
-0.0031037796288728714,
0.032027073204517365,
0.0016198663506656885,
0.045726511627435684,
0.061369795352220535,
0.004949270281940699,
-0.0022403330076485872,
-0.03438744693994522,
0.006554673425853252,
0.048272017389535904,
-0.017205294221639633,
-0.05294648930430412,
-0.0038645383901894093,
-0.009140674024820328,
-0.003896357025951147,
-0.009308446198701859,
0.00015647258260287344,
0.00204218877479434,
-0.00956299714744091,
0.029273299500346184,
-0.05498289316892624,
-0.01751769706606865,
-0.02589472010731697,
-0.043597545474767685,
-0.07030220329761505,
-0.04605048522353172,
-0.08099331706762314,
-0.011784527450799942,
0.00044690954382531345,
0.009429936297237873,
-0.03142540901899338,
-0.008654714561998844,
0.029018748551607132,
0.039200764149427414,
0.041376013308763504,
-0.005603001918643713,
-0.036539558321237564,
0.019878074526786804,
-0.005507545545697212,
0.04780919849872589,
-0.041260309517383575,
-0.029898105189204216,
0.011772957630455494,
-0.01678875833749771,
0.05600109323859215,
0.017286287620663643,
0.01785324141383171,
-0.009406795725226402,
0.016221804544329643,
0.04767035320401192,
-0.014393669553101063,
-0.031980790197849274,
0.037071797996759415,
-0.02568645216524601,
-0.03339238837361336,
0.012901078909635544,
-0.018119363114237785,
0.014266394078731537,
-0.04119088873267174,
0.04845714569091797,
0.0015417656395584345,
0.008400164544582367,
0.04547196254134178,
0.005044726654887199,
-0.0005297107854858041,
-0.00010304953320883214,
-0.03228162229061127,
-0.0019105745013803244,
0.012623387388885021,
0.06067556515336037,
0.024506263434886932,
0.017089590430259705,
-0.024529404938220978,
-0.013225051574409008,
0.0031124574597924948,
0.018454905599355698,
-0.06086069345474243,
0.007972056977450848,
0.00609185453504324,
-0.03862224146723747,
0.016013536602258682,
-0.023788895457983017,
-0.019299549981951714,
0.015863120555877686,
0.02531619742512703,
-0.030314641073346138,
-0.02404344454407692,
-0.057713523507118225,
0.024668250232934952,
-0.00888612400740385,
0.0700707882642746,
-0.021960759535431862,
0.0027523264288902283,
-0.00016316176333930343,
0.01994749717414379,
-0.06113838404417038,
-0.01740199327468872,
-0.01730942912399769,
-0.0025917862076312304,
-0.056649040430784225,
0.014266394078731537,
-0.0030314642935991287,
0.01390771009027958,
-0.00870099663734436,
-0.018570611253380775,
0.02219216898083687,
0.026820357888936996,
0.02658894844353199,
0.05539942905306816,
-0.049012526869773865,
0.017124300822615623,
-0.03431802615523338,
0.01719372346997261,
0.02146322838962078,
-0.037118081003427505,
-0.04211652651429176,
-0.05576968565583229,
-0.013352327048778534,
-0.001888879924081266,
0.04574965313076973,
0.019542530179023743,
0.0006258903304114938,
0.031332843005657196,
0.03283700346946716,
0.006473680026829243,
-0.039987556636333466,
-0.051187776029109955,
0.01052334625273943,
-0.023534344509243965,
0.024182289838790894,
0.014844917692244053,
0.007347250822931528,
0.006039787549525499,
0.008741493336856365,
0.0025787693448364735,
-0.025408761575818062,
-0.021845055744051933,
-0.020688006654381752,
-0.01982022263109684,
-0.00466868607327342,
-0.011807668954133987,
-0.017783818766474724,
0.0007795607089065015,
0.0022374403197318316,
-0.017043307423591614,
0.007607586681842804,
-0.01661520078778267,
0.026658372953534126,
-0.014659790322184563,
-0.03688666969537735,
-0.04336613789200783,
-0.008203466422855854,
-0.0379280149936676,
0.004445954691618681,
-0.0057939146645367146,
-0.05674160271883011,
0.04197768121957779,
0.012600245885550976,
0.019565671682357788,
0.014335817657411098,
0.03140226751565933,
0.026565808802843094,
0.0289261844009161,
0.0019423933699727058,
0.031494829803705215,
0.0541498176753521,
0.004202974494546652,
0.01541187148541212,
0.01719372346997261,
-0.0477629154920578,
0.024182289838790894,
-0.014520945027470589,
-0.03730320930480957,
-0.027514588087797165,
-0.03274444118142128,
0.02010948397219181,
0.02925015799701214,
-0.02573273330926895,
0.02367318980395794,
-0.01698545552790165,
0.028324520215392113,
-0.03869166597723961,
0.013248193077743053,
-0.05132662132382393,
0.06335991621017456,
-0.015041615813970566,
0.010106809437274933,
-0.014949052594602108,
-0.053039051592350006,
-0.03434116765856743,
0.005449693184345961,
0.03082374297082424,
-0.004038095474243164,
0.037071797996759415,
-0.0326518788933754,
0.06340619921684265,
-0.008330740965902805,
-0.0015880475984886289,
0.012901078909635544,
0.007474526297301054,
-0.0050591896288096905,
0.019137563183903694,
0.008128258399665356,
0.012472971342504025,
0.0006226361147128046,
0.01210271567106247,
-0.03258245438337326,
0.045078568160533905,
-0.02338392846286297,
-0.0076654390431940556,
0.03174937888979912,
0.020155765116214752,
0.0034711421467363834,
-0.011819238774478436,
-0.05780608952045441,
0.02257399447262287,
0.04924393817782402,
0.05567711964249611,
-0.006687733810395002,
0.026936063542962074,
-0.05109521374106407,
-0.03195764869451523,
-0.002808732446283102,
0.00382693437859416,
0.0077290767803788185,
0.006519962102174759,
-0.022273162379860878,
0.05211341381072998,
0.016117669641971588,
0.011663037352263927,
0.045726511627435684,
-0.018119363114237785,
0.037812307476997375,
-0.017945805564522743,
-0.0030922091100364923,
-0.027838559821248055,
-0.01612924039363861,
0.023210370913147926,
-0.00791998952627182,
-0.027514588087797165,
-0.07344936579465866,
0.012079575099050999,
-0.015203602612018585,
-0.01809622161090374,
-0.008996043354272842,
0.009279520250856876,
-0.002231655176728964,
0.06442439556121826,
-0.0070001366548240185,
0.06775669753551483,
0.020792141556739807,
-0.010505990125238895,
0.03332296386361122,
-0.009493573568761349,
-0.005041833966970444,
-0.03211963549256325,
0.007630727719515562,
-0.012380407191812992,
0.05461263656616211,
0.01767968386411667,
0.016221804544329643,
0.0005890094325877726,
-0.0064447540789842606,
0.007879492826759815,
0.029065031558275223,
0.04891996458172798,
0.01481020636856556,
-0.02520049177110195,
-0.030522910878062248,
0.026241835206747055,
-0.024668250232934952,
0.0008403056999668479,
0.04197768121957779,
-0.01278537418693304,
0.02091941609978676,
-0.002476081484928727,
-0.0022359942086040974,
0.0013920726487413049,
0.023615337908267975,
0.014775495044887066,
0.03306841477751732,
-0.05637134984135628,
-0.006051357835531235,
0.04461574926972389,
-0.023950880393385887,
-0.023129377514123917,
-0.03380892425775528,
0.020456597208976746,
-0.040519800037145615,
0.014023414812982082,
-0.04288017749786377,
0.024112867191433907,
-0.034850265830755234,
-0.01596725359559059,
0.009343157522380352,
-0.012218420393764973,
0.020364034920930862,
-0.018535898998379707,
0.0009740892564877868,
0.013803575187921524,
-0.014220112934708595,
-0.013699441216886044,
-0.03970986604690552,
-0.024136008694767952,
-0.0025238096714019775,
0.017344141378998756,
-0.030638614669442177,
-0.01419697143137455,
0.0060687134973704815,
-0.049753036350011826,
0.01637222059071064,
0.033785782754421234,
0.05766724422574043,
-0.05900941789150238,
0.009834903292357922,
-0.010679547674953938,
-0.0294584259390831,
0.02675093524158001,
0.051511749625205994,
-0.009493573568761349,
0.03866852447390556,
-0.01859375089406967,
-0.01019358728080988,
0.008672070689499378,
0.016013536602258682,
0.014671361073851585,
-0.0183044895529747,
0.0244136992841959,
0.0165804885327816,
0.0052703507244586945,
0.026866640895605087,
-0.006716660223901272,
-0.008874553255736828,
-0.014393669553101063,
-0.023974021896719933,
-0.03191136568784714,
-0.00031023332849144936,
0.03450315445661545,
-0.005851767025887966,
0.036169301718473434,
-0.023974021896719933,
0.023360786959528923,
-0.006271196994930506,
0.0033930414356291294,
0.01993592642247677,
-0.009655560366809368,
-0.02483023703098297,
-0.006473680026829243,
0.015377160161733627,
-0.0023936417419463396,
0.02691292203962803,
-0.014451522380113602,
-0.011113440617918968,
0.00037278622039593756,
0.0019105745013803244,
0.004709182772785425,
0.03357751667499542,
0.035475071519613266,
0.02654266729950905,
0.02589472010731697,
-0.0092158829793334,
0.052298542112112045,
-0.032883286476135254,
-0.018859872594475746,
0.024066586047410965,
-0.006410042755305767,
-0.051511749625205994,
-0.030661756172776222,
-0.05711185932159424,
-0.00004781860116054304,
-0.016302797943353653,
0.010916742496192455,
-0.014914341270923615,
-0.019507819786667824,
0.012993642129004002,
0.01323662232607603,
0.027398882433772087,
-0.019519390538334846,
-0.02425171434879303,
0.00009943376062437892,
-0.03279072418808937,
-0.025663310661911964,
0.04008012264966965,
-0.020572302863001823,
-0.002269259188324213,
0.007810069713741541,
-0.013433320447802544,
-0.02658894844353199,
-0.036215584725141525,
0.013711011968553066,
-0.018188785761594772,
-0.008741493336856365,
0.031656816601753235,
-0.016962314024567604,
0.03681724891066551,
-0.013572165742516518,
-0.003005430568009615,
0.006982780992984772,
-0.0010666530579328537,
-0.04649016633629799,
0.03195764869451523,
-0.019091282039880753,
0.021821914240717888,
-0.024228572845458984,
0.011709319427609444,
0.0033930414356291294,
0.010291936807334423,
-0.00191346718929708,
-0.015296166762709618,
-0.03626186400651932,
-0.010372930206358433,
-0.011501051485538483,
-0.017459845170378685,
-0.018802020698785782,
-0.005805485416203737,
-0.03353123366832733,
-0.005073653068393469,
0.006195988971740007,
-0.001258289092220366,
-0.012715950608253479,
-0.006890217307955027,
0.0183044895529747,
-0.0030748534481972456,
-0.013063064776360989,
0.0003232501039747149,
-0.009863829240202904,
0.05859288200736046,
0.004252149257808924,
0.006959639955312014,
0.013641588389873505,
0.022597135975956917,
0.01151262130588293,
-0.028532788157463074,
0.005683995317667723,
-0.011032447218894958,
0.03151797130703926,
0.0010471278801560402,
0.010667976923286915,
-0.041052043437957764,
0.0014108746545389295,
-0.03302213177084923,
-0.028046829625964165,
0.042741332203149796,
-0.01637222059071064,
0.027236895635724068,
0.023788895457983017,
-0.02855592966079712,
0.02331450581550598,
0.02675093524158001,
-0.01368787046521902,
-0.007850566878914833,
-0.02035246416926384,
0.029227016493678093,
-0.01595568284392357,
-0.0015547823859378695,
-0.039501599967479706,
-0.04091319441795349,
0.0012835994130000472,
-0.019380543380975723,
-0.01358373649418354,
0.032605595886707306,
0.01427796483039856,
0.0352899469435215,
0.005423659458756447,
-0.03804371878504753,
-0.0015012690564617515,
0.015377160161733627,
-0.0012908310163766146,
-0.037974294275045395,
-0.02093098685145378,
0.0032426253892481327,
-0.007810069713741541,
-0.04771663621068001,
-0.009597708471119404,
-0.02293268032371998,
0.007069559767842293,
-0.024274853989481926,
-0.03246675059199333,
-0.02383517660200596,
-0.01703173853456974,
0.014139119535684586,
-0.015828408300876617,
-0.02818567492067814,
-0.03114771656692028,
0.008915049955248833,
0.02864849381148815,
0.007364606484770775,
-0.03323040157556534,
0.010436567477881908,
-0.010725829750299454,
-0.016487926244735718,
0.013792005367577076,
-0.03852967917919159,
-0.002062436891719699,
0.022550852969288826,
-0.014902770519256592,
0.01993592642247677,
-0.021937618032097816,
-0.02584843896329403,
0.002438477473333478,
0.012461400590837002,
0.0009068358922377229,
-0.011275426484644413,
0.0044170282781124115,
0.015330878086388111,
-0.023650048300623894,
0.00330337043851614,
-0.001979997381567955,
0.023048384115099907,
-0.011535762809216976,
0.06886745989322662,
0.061323512345552444,
-0.041792552918195724,
0.03491969034075737,
-0.006074498873203993,
-0.0017861919477581978,
-0.01793423481285572,
0.005281921476125717,
0.005038941279053688,
-0.014312676154077053,
0.005073653068393469,
0.01690446212887764,
0.07127411663532257,
0.01637222059071064,
-0.0032570883631706238,
-0.010760541073977947,
0.008255532942712307,
0.00820925086736679,
0.004133551847189665,
-0.02215745858848095,
-0.038228847086429596,
0.03591475263237953,
-0.001417383085936308,
-0.014706072397530079,
-0.02658894844353199,
-0.07034847885370255,
-0.0054207672365009785,
0.02589472010731697,
0.02244671992957592,
0.013630018569529057,
0.012739092111587524,
-0.016939174383878708,
-0.007202620152384043,
-0.02293268032371998,
-0.028000546619296074,
-0.0016299905255436897,
0.0344800129532814,
0.012334125116467476,
-0.020537590608000755,
-0.010228298604488373,
-0.024691391736268997,
0.006109210196882486,
0.012935790233314037,
0.018640033900737762,
0.05072495713829994,
-0.03045348823070526,
0.019959067925810814,
-0.015724273398518562,
0.020364034920930862,
-0.00765386875718832,
-0.0011628326028585434,
0.04521741345524788,
0.020167335867881775,
0.021035121753811836,
-0.03320726007223129,
-0.026403822004795074,
-0.004746786784380674,
0.003291799919679761,
0.005776559002697468,
0.028787339106202126,
0.012669669464230537,
0.0038847867399454117,
-0.012889508157968521,
0.0184317659586668,
-0.012033293023705482,
0.001429676660336554,
0.026079848408699036,
0.021035121753811836,
-0.031286559998989105,
0.04429177567362785,
7.316290862036112e-7,
-0.01595568284392357,
0.0027479876298457384,
-0.019704516977071762,
-0.030870024114847183,
-0.0022634740453213453,
-0.028370801359415054,
0.01103823259472847,
-0.012843226082623005,
-0.007607586681842804,
-0.0267972182482481,
-0.009788621217012405,
0.034410588443279266,
-0.007457170635461807,
0.009291091002523899,
0.014763925224542618,
-0.006815009284764528,
0.031032010912895203,
0.017182154580950737,
-0.011680393479764462,
-0.012114286422729492,
-0.016973884776234627,
0.019010288640856743,
0.0080241234973073,
-0.00023610999051015824,
-0.0028636923525482416,
-0.010991950519382954,
-0.0161755234003067,
-0.005614572670310736,
0.02006320282816887,
-0.026727795600891113,
-0.01629122719168663,
-0.008660499937832355,
-0.015319307334721088,
0.01157047413289547,
0.0035000683274120092,
0.0059125120751559734,
0.004263719543814659,
0.007601801306009293,
0.018061509355902672,
0.02285168692469597,
0.014416811056435108,
-0.02753772772848606,
-0.027236895635724068,
0.024112867191433907,
-0.022273162379860878,
-0.015458153560757637,
0.015539146959781647,
-0.035266805440187454,
0.018767308443784714,
-0.03619244322180748,
0.008990257978439331,
-0.00863735843449831,
0.004613726399838924,
0.0033930414356291294,
0.025293055921792984,
-0.018038369715213776,
-0.026334399357438087,
0.0001035015084198676,
0.016592059284448624,
-0.03279072418808937,
-0.010158875957131386,
-0.0048567065969109535,
0.020688006654381752,
-0.029967527836561203,
0.011252285912632942,
0.0031124574597924948,
0.029597273096442223,
0.05752839520573616,
-0.0928414836525917,
-0.02359219640493393,
0.011929159052670002,
0.003780652303248644,
-0.00466868607327342,
0.013896139338612556,
-0.002821749309077859,
0.0027335244230926037,
0.022226881235837936,
-0.018026798963546753,
0.01793423481285572,
-0.003497175872325897,
0.011286997236311436,
-0.000446186400949955,
-0.016152381896972656,
-0.042486779391765594,
-0.007370391860604286,
-0.04510170593857765,
0.007266257889568806,
0.054844047874212265,
-0.0004454632580745965,
0.028671635314822197,
-0.003557920688763261,
0.07030220329761505,
0.012403547763824463,
0.01297050155699253,
-0.02273598127067089,
-0.00561167998239398,
-0.029481567442417145,
-0.025385620072484016,
0.02154422178864479,
0.015620139427483082,
-0.023002102971076965,
0.02765343338251114,
0.0024746351409703493,
-0.03538250923156738,
0.023742612451314926,
-0.0034306454472243786,
-0.027954265475273132,
0.0055596125312149525,
-0.000028813192329835147,
-0.006334834732115269,
0.0329064279794693,
0.017656544223427773,
-0.006479465402662754,
-0.01368787046521902,
-0.03318411856889725,
-0.0018773094052448869,
0.009082822129130363,
-0.02552446536719799,
0.013537454418838024,
-0.0366089791059494,
-0.033947769552469254,
-0.006572029087692499,
-0.004312894307076931,
-0.01941525563597679,
0.01625651679933071,
0.015296166762709618,
0.009632419794797897,
0.015273025259375572,
-0.02663523145020008,
0.0673864409327507,
0.011535762809216976,
-0.018165644258260727,
0.0018469368806108832,
-0.01767968386411667,
-0.04998444765806198,
0.025755874812602997,
-0.05581596493721008,
-0.003369900630787015,
0.0188367310911417,
-0.01331761572510004,
-0.04188511520624161,
0.04100576043128967,
0.0034335381351411343,
0.012322554364800453,
0.005380270536988974,
-0.014208542183041573,
-0.0026785647496581078,
0.028532788157463074,
0.005872015375643969,
0.0014911448815837502,
0.005834411364048719,
0.015654850751161575,
-0.012160568498075008,
0.038552820682525635,
0.018894584849476814,
0.011501051485538483,
0.00810511689633131,
-0.01870945654809475,
0.010309292003512383,
-0.0004577568906825036,
0.005001337267458439,
0.014046555384993553,
0.006363760679960251,
-0.0072836135514080524,
-0.025825297459959984,
0.011894447728991508,
-0.01727471686899662,
-0.020213618874549866,
0.04739266261458397,
-0.06118466705083847,
-0.0005141629371792078,
-0.020653296262025833,
-0.02871791645884514,
-0.0017789603443816304,
0.035151101648807526,
0.002162232296541333,
0.008058834820985794,
-0.027977406978607178,
0.0368635319173336,
-0.007688580080866814,
0.019010288640856743,
0.0035232093650847673,
0.004162477795034647,
0.006369546055793762,
0.008134042844176292,
-0.0012553964043036103,
0.019461536779999733,
-0.002882494358345866,
0.05183572322130203,
0.012877937406301498,
-0.01641850173473358,
-0.010500204749405384,
0.003369900630787015,
-0.0011028108419850469,
0.007717506028711796,
0.014752354472875595,
0.010858889669179916,
0.01767968386411667,
0.024274853989481926,
-0.010239869356155396,
0.0021564471535384655,
-0.01695074513554573,
0.011686178855597973,
0.04202396050095558,
0.014393669553101063,
0.03811313956975937,
-0.002085577929392457,
0.024274853989481926,
0.008458016440272331,
-0.01220684964209795,
-0.007769573479890823,
-0.043435558676719666,
0.03545193374156952,
-0.0041219815611839294,
-0.038923073559999466,
0.009256378747522831,
0.005091008730232716,
-0.009036540053784847,
-0.04533311724662781,
0.019889645278453827,
0.06622939556837082,
0.05391841009259224,
-0.009285305626690388,
0.018443334847688675,
0.026288116350769997,
-0.035961031913757324,
-0.018073080107569695,
0.016314368695020676,
-0.04952162876725197,
0.03776602819561958,
-0.035637058317661285,
-0.007040633354336023,
0.023661619052290916,
-0.0070869154296815395,
-0.0033554374240338802,
0.005128612741827965,
0.04202396050095558,
0.014243253506720066,
0.010413426905870438,
-0.07085758447647095,
0.06007390096783638,
-0.004043880850076675,
-0.017413564026355743,
0.024321136996150017,
0.026565808802843094,
-0.012172138318419456,
0.012577105313539505,
0.017286287620663643,
-0.03577590733766556,
-0.007833210751414299,
0.02104669250547886,
0.03737263008952141,
0.015273025259375572,
-0.010685333050787449,
0.002990967594087124,
-0.041630566120147705,
0.007995197549462318,
-0.014046555384993553,
-0.019646665081381798,
-0.008116687647998333,
-0.007434029597789049,
0.04260248690843582,
0.03936275094747543,
-0.017795389518141747,
-0.024483123794198036,
0.022886397317051888,
-0.025038504973053932,
-0.04521741345524788,
-0.033299822360277176,
0.036747824400663376,
0.047624070197343826,
-0.013433320447802544,
-0.026334399357438087,
0.024899659678339958,
0.024274853989481926,
-0.03644699230790138,
-0.0013465138617902994,
0.03364693745970726,
-0.01069111842662096,
0.05169687792658806,
-0.046999264508485794,
0.03392462804913521,
0.0289261844009161,
0.0059992908500134945,
-0.007237331476062536,
0.0012901078443974257,
-0.03114771656692028,
-0.02211117558181286,
-0.03776602819561958,
-0.037395771592855453,
0.010720044374465942,
0.0020826852414757013,
-0.02178720198571682,
0.010118379257619381,
0.03714122250676155,
0.0047005051746964455,
-0.007451385259628296,
0.020792141556739807,
-0.01677718758583069,
0.007387747522443533,
0.028324520215392113,
0.017008597031235695,
-0.004674471449106932,
-0.006496821064502001,
-0.007133197039365768,
-0.025547606870532036,
0.018697885796427727,
0.016152381896972656,
0.04010326415300369,
-0.0331609770655632,
0.0011772956931963563,
-0.03901563957333565,
-0.013815145939588547,
-0.005513330921530724,
0.02999066933989525,
-0.017830099910497665,
-0.005403411574661732,
0.012762232683598995,
0.0003679049259517342,
0.010436567477881908,
0.020491309463977814,
0.03142540901899338,
0.02712119184434414,
-0.009597708471119404,
0.03804371878504753,
0.016545778140425682,
0.021509511396288872,
0.010291936807334423,
0.0005712921265512705,
0.004850921221077442,
-0.028509648516774178,
-0.010106809437274933,
0.01821192540228367,
-0.015909401699900627,
0.002665547886863351,
-0.0210929736495018,
0.023083096370100975,
0.02749144658446312,
0.023129377514123917,
0.00894397683441639,
-0.027098050341010094,
0.00417404854670167,
-0.006433183327317238,
-0.013780434615910053,
0.03836769238114357,
-0.018605321645736694,
-0.006410042755305767,
-0.0003171033167745918,
-0.001969873206689954,
-0.007462955545634031,
-0.020005349069833755,
0.0005937099340371788,
0.0038009006530046463,
0.0267972182482481,
-0.006323263980448246,
-0.02305995486676693,
-0.004755464848130941,
-0.023372357711195946,
-0.022145887836813927,
0.008215036243200302,
0.004671578761190176,
-0.003696766449138522,
-0.000853322446346283,
-0.020491309463977814,
-0.0017616046825423837,
0.0011556011158972979,
-0.007312539499253035,
-0.013097776100039482,
0.007989412173628807,
0.04116774722933769,
-0.01376886386424303,
-0.03501225262880325,
0.024598827585577965,
-0.049382783472537994,
-0.02769971452653408,
-0.04804060980677605,
0.04521741345524788,
-0.00516910944133997,
-0.022782262414693832,
0.004098840523511171,
0.0387379452586174,
-0.0376734621822834,
0.019137563183903694,
0.020340893417596817,
-0.021035121753811836,
0.015608569607138634,
0.017008597031235695,
0.0167077649384737,
-0.011171292513608932,
0.00103628053329885,
0.00469761248677969,
-0.03364693745970726,
-0.01612924039363861,
-0.01595568284392357,
0.011761386878788471,
-0.01122335996478796,
-0.023279793560504913,
-0.04623561352491379,
0.0384833961725235,
-0.026565808802843094,
0.017344141378998756,
0.00304592726752162,
0.014520945027470589,
0.009522500447928905,
-0.0075728753581643105,
-0.015596998855471611,
0.0034566791728138924,
0.0002814879408106208,
-0.014312676154077053,
0.011599400080740452,
0.010419212281703949,
0.03230476379394531,
0.02351120300590992,
-0.012357266619801521,
-0.028463365510106087,
-0.02589472010731697,
-0.02557074837386608,
-0.009551426395773888,
0.05063239485025406,
-0.02557074837386608,
-0.006271196994930506,
0.03114771656692028,
0.005782344378530979,
-0.003685195930302143,
-0.01427796483039856,
0.009053896181285381,
0.01263495720922947,
0.010835749097168446,
-0.020815283060073853,
0.012345695868134499,
0.04947534576058388,
-0.01727471686899662,
0.014173830859363079,
0.010899386368691921,
-0.006311693694442511,
-0.009557211771607399,
-0.018165644258260727,
-0.01177874207496643,
0.003028571605682373,
0.028787339106202126,
-0.027769137173891068,
-0.01888301409780979,
0.027584010735154152,
0.0036678402684628963,
0.05974992737174034,
0.026241835206747055,
0.004266612231731415,
0.04202396050095558,
0.013606877066195011,
-0.030129514634609222,
-0.014671361073851585,
-0.023198800161480904,
-0.02844022586941719,
-0.008972902782261372,
-0.031055152416229248,
-0.02249300107359886,
0.00267277960665524,
-0.002531041158363223,
-0.009632419794797897,
-0.009539855644106865,
0.0020552054047584534,
-0.013410178944468498,
-0.042857035994529724,
-0.012854796834290028,
-0.0007672670762985945,
0.005773666314780712,
-0.026658372953534126,
0.010615909472107887,
-0.012935790233314037,
-0.01715901307761669,
0.016360649839043617,
-0.01624494604766369,
0.012681239284574986,
0.020711148157715797,
0.0217524915933609,
0.00904811080545187,
0.0015142858028411865,
-0.002374839736148715,
-0.002581662032753229,
-0.006282767280936241,
-0.06567400693893433,
0.013190340250730515,
-0.025917861610651016,
0.01218370907008648,
-0.004043880850076675,
-0.017205294221639633,
-0.015273025259375572,
-0.02536247856914997,
0.017378851771354675,
-0.006311693694442511,
-0.005108364392071962,
0.011587829329073429,
-0.007515022996813059,
0.013896139338612556,
0.006815009284764528,
0.006282767280936241,
-0.05475148186087608,
0.020248329266905785,
-0.007468740921467543,
0.01563171111047268,
0.024645108729600906,
-0.016360649839043617,
-0.026450103148818016,
0.001964088063687086,
-0.016719335690140724,
-0.008753063157200813,
-0.01382671669125557,
-0.0032368400134146214,
-0.001481020706705749,
0.015342448838055134,
0.05979621037840843,
-0.0020653295796364546,
0.0012814300134778023,
-0.018975578248500824,
-0.008261318318545818,
0.0004418474854901433,
0.004960840567946434,
0.00553068658336997,
0.023245083168148994,
0.01703173853456974,
-0.0331609770655632,
-0.00304592726752162,
-0.019727658480405807,
0.0038761086761951447,
-0.03524366393685341,
-0.006334834732115269,
0.018697885796427727,
0.008666285313665867,
-0.027236895635724068,
-0.02022518776357174,
-0.0013696548994630575,
-0.0020118162501603365,
0.005565397907048464,
0.020699577406048775,
-0.009111748076975346,
0.0000044745193008566275,
-0.026450103148818016,
-0.0021029335912317038,
0.015238313935697079,
0.00684393523260951,
0.042903319001197815,
0.003540565026924014,
0.04878111928701401,
-0.02141694724559784,
0.0419313982129097,
0.007873707450926304,
0.02113925665616989,
-0.02088470570743084,
-0.02199547179043293,
0.0003384363662917167,
0.01695074513554573,
-0.022169027477502823,
0.011286997236311436,
0.036956094205379486,
-0.014694501645863056,
-0.012137426994740963,
0.029759259894490242,
-0.014058126136660576,
0.029319580644369125,
-0.014509374275803566,
0.012808514758944511,
-0.0007744986214675009,
-0.031055152416229248,
-0.010841534473001957,
0.03725692629814148,
-0.014949052594602108,
-0.011044017039239407,
-0.005232746712863445,
-0.005791022442281246,
-0.004897203296422958,
-0.006901787593960762,
-0.011258071288466454,
0.004552981350570917,
-0.002911420539021492,
-0.03556763753294945,
-0.07071873545646667,
0.020838424563407898,
0.01356059592217207,
-0.013352327048778534,
-0.00837123766541481,
-0.007029063068330288,
0.02064172551035881,
0.04468517005443573,
-0.05104893073439598,
-0.006034002173691988,
0.023696331307291985,
0.026195552200078964,
0.006467895116657019,
-0.01743670366704464,
0.016140811145305634,
0.004255041945725679,
-0.007277828175574541,
-0.0009147906093858182,
-0.021000409498810768,
0.022412007674574852,
0.02774599753320217,
-0.021775631234049797,
0.018651604652404785,
0.04021896794438362,
-0.011790312826633453,
0.0007184541318565607,
-0.006907572969794273,
-0.011894447728991508,
0.041584283113479614,
-0.022909538820385933,
-0.01719372346997261,
-0.008955546654760838,
-0.0049810889177024364,
-0.01891772449016571,
-0.008903480134904385,
0.03140226751565933,
-0.004301323555409908,
0.003870323533192277,
0.02802368812263012,
0.011882876977324486,
-0.022874826565384865,
-0.020711148157715797,
0.02790798246860504,
0.060999538749456406,
-0.0025252560153603554,
-0.0017529268516227603,
-0.00307196076028049,
-0.004570337012410164,
-0.008938191458582878,
-0.004240578506141901,
-0.003485605353489518,
-0.013919279910624027,
0.006248055957257748,
0.013167199678719044,
0.03082374297082424,
0.029759259894490242,
0.012218420393764973,
-0.01175560150295496,
0.0016054032603278756,
-0.023210370913147926,
-0.00801833812147379,
0.0016950744902715087,
-0.002176695503294468,
-0.01899871788918972,
-0.015354018658399582,
-0.018200356513261795,
0.006467895116657019,
-0.012519252486526966,
0.019357403740286827,
-0.005446800496429205,
0.005851767025887966,
0.015284596011042595,
-0.002519470639526844,
-0.016140811145305634,
0.036701545119285583,
-0.033994052559137344,
0.027977406978607178,
0.0003574191650841385,
-0.04063550382852554,
-0.03570648282766342,
-0.0028116251341998577,
-0.0029302225448191166,
0.0010066311806440353,
-0.0339709110558033,
0.004156692884862423,
0.002152108121663332,
0.006340619642287493,
-0.0028781553264707327,
0.010372930206358433,
-0.0007853459101170301,
-0.014104408212006092,
-0.0294584259390831,
-0.003277336712926626,
-0.013491172343492508,
0.023464921861886978,
-0.002922991057857871,
-0.007694364991039038,
-0.00020320645126048476,
-0.015099468640983105,
-0.014914341270923615,
-0.016892891377210617,
-0.01567799225449562,
-0.007590231020003557,
-0.021440088748931885,
0.013456461019814014,
-0.028417084366083145,
-0.0005300723132677376,
-0.013259762898087502,
0.01719372346997261,
-0.04331985488533974,
0.010882031172513962,
-0.003881894052028656,
-0.01202172227203846,
0.038552820682525635,
0.04334299638867378,
-0.02371947094798088,
0.019681375473737717,
-0.004512484651058912,
0.021359095349907875,
-0.030060091987252235,
0.005244317464530468,
0.02547818422317505,
-0.02436741814017296,
0.003083531279116869,
0.025223633274435997,
0.024552546441555023,
-0.04144543781876564,
-0.0011078729294240475,
-0.019808651879429817,
-0.0047062900848686695,
0.01462507899850607,
-0.02663523145020008,
0.01982022263109684,
-0.011906017549335957,
0.006126565858721733,
0.013919279910624027,
0.03311469778418541,
-0.03975614905357361,
0.01825820840895176,
-0.00939522497355938,
0.01887144334614277,
0.012715950608253479,
-0.008249747566878796,
-0.004197189584374428,
-0.005542256869375706,
0.010905171744525433,
0.021798772737383842,
0.011373776011168957,
0.018165644258260727,
-0.00453562568873167,
0.022631846368312836,
-0.022597135975956917,
-0.0035781690385192633,
0.012658098712563515,
-0.012357266619801521,
-0.01411597803235054,
0.02971297688782215,
0.008706782013177872,
-0.006774512585252523,
0.025617029517889023,
-0.0037054442800581455,
-0.012808514758944511,
-0.013340756297111511,
-0.031193997710943222,
-0.005475726909935474,
-0.025084787979722023,
0.0008887570584192872,
0.14504745602607727,
-0.009140674024820328,
-0.007908418774604797,
0.005085223354399204,
0.0366089791059494,
-0.023499632254242897,
0.01374572329223156,
0.007312539499253035,
0.01339860912412405,
-0.010511775501072407,
0.025431901216506958,
0.05183572322130203,
0.025987284258008003,
0.006057143211364746,
0.018767308443784714,
-0.03443372994661331,
0.004246363881975412,
0.03869166597723961,
-0.014208542183041573,
-0.003448001341894269,
0.007775358390063047,
-0.005082330666482449,
-0.015192032791674137,
0.026450103148818016,
-0.04723067581653595,
0.009967963211238384,
0.002062436891719699,
-0.006780297961086035,
-0.00404098816215992,
-0.006560458801686764,
0.011645682156085968,
-0.007925774902105331,
0.016349079087376595,
-0.008562150411307812,
0.011425843462347984,
-0.058778006583452225,
-0.020121054723858833,
-0.020132625475525856,
0.019912784919142723,
-0.012299413792788982,
0.006838150322437286,
-0.007752217352390289,
-0.017170583829283714,
0.009285305626690388,
0.032189060002565384,
0.019264839589595795,
-0.03327668458223343,
-0.0052240691147744656,
0.008839841932058334,
-0.03279072418808937,
-0.018061509355902672,
-0.020051632076501846,
-0.013167199678719044,
-0.03704865649342537,
-0.039617303758859634,
-0.025917861610651016,
0.010685333050787449,
0.011020876467227936,
0.017170583829283714,
-0.04246363788843155,
-0.029412144795060158,
0.00527324341237545,
0.04024210944771767,
-0.01714744232594967,
0.01297050155699253
] | 2025-01-22 | 1 | 39841806 | [
"CAR)-T cell therapies",
"solid tumors",
"tumor",
"Chimeric antigen receptor",
"improved CAR-T cell therapy",
"target",
"CAR-T cells",
"cancer treatment",
"tumor-specific antigens",
"migration molecules",
"the CAR target antigen",
"CAR-T therapy",
"blocking antibodies",
"CAR",
"nonmalignant tissues",
"clinical trials",
"hematologic malignancies",
"the cell adhesion",
"CD11a",
"CAR)-T",
"very late activation",
"CD49d/CD29",
"mice",
"CD11a/CD18",
"the context",
"the landscape",
"(LFA-1",
"the need",
"this observation",
"this issue"
] | [] | 0 | 10.1126/scitranslmed.adl6432 | [
"Wang",
"Wu",
"Cui",
"Bian",
"Zheng",
"Zhu",
"Geng",
"Sun",
"Pan",
"Shi",
"Yi",
"Song",
"Li",
"Shen",
"Li",
"Shen",
"Yan",
"Hao",
"Sun",
"Zhang",
"Zhang",
"Jin",
"Zhai"
] | [
"Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.\nShanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.\nShanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Mini-invasive Interventional Therapy Center, Shanghai East Hospital, Tongji University, Shanghai 200025, China.",
"Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.\nShanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Shanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Shanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.",
"Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Suzhou Immunofoco Biotechnology Co. Ltd, Suzhou, Jiangsu 215000, China.",
"Mini-invasive Interventional Therapy Center, Shanghai East Hospital, Tongji University, Shanghai 200025, China.",
"Suzhou Immunofoco Biotechnology Co. Ltd, Suzhou, Jiangsu 215000, China.",
"Department of Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200025, China.",
"Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200025, China.",
"Shanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Suzhou Immunofoco Biotechnology Co. Ltd, Suzhou, Jiangsu 215000, China.",
"Suzhou Immunofoco Biotechnology Co. Ltd, Suzhou, Jiangsu 215000, China.",
"Suzhou Immunofoco Biotechnology Co. Ltd, Suzhou, Jiangsu 215000, China.",
"Department of Urology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.",
"Shanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.",
"Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.\nShanghai Cancer Institute, State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.\nMini-invasive Interventional Therapy Center, Shanghai East Hospital, Tongji University, Shanghai 200025, China."
] | [
"39841806"
] | [] | 8.998252 | 5.280612 |
39840882 | 6 | [Patient with diffuse large B-cell lymphoma: a good example of network in care.]. | Chimeric Antigen Receptor T cell (CAR-T) therapy has revolutionized prognosis of patients with diffuse large B-cell lymphoma (DLBCL). Success of CAR-T treatment heavily relies on early referral to the CAR-T center, on a short time of infusion of CAR-T cells from the lymphocyte collection and on a reduced burden of disease. Here we describe the case of a patient with diagnosis of High-grade B-cell lymphoma with MYC and BCL6 rearrangements, transformed from marginal zone lymphoma, referred with a refractory and rapidly progressive disease. The patient received holding therapy, with the aim to control the disease before apheresis, and subsequently treated with a combined bridging therapy, achieving a metabolic complete remission. Patient is still in complete remission at 21 months from infusion. This report represents a case of a correct referral and a full collaboration between centers. | [
0.018854942172765732,
0.02260638028383255,
0.052886709570884705,
0.06867451965808868,
-0.024256035685539246,
0.012384630739688873,
-0.02891172654926777,
0.043184295296669006,
-0.01984473504126072,
0.004994788207113743,
0.006684156600385904,
-0.013698244467377663,
-0.054548583924770355,
-0.011871404014527798,
0.03995830565690994,
0.012360190972685814,
0.06486198306083679,
0.008675961755216122,
-0.0050833807326853275,
0.054450828582048416,
0.015470095910131931,
0.017840711399912834,
0.005535508040338755,
-0.021359974518418312,
-0.04875646159052849,
-0.02117667905986309,
-0.005101710092276335,
0.006519191432744265,
-0.032602064311504364,
-0.03384847193956375,
0.02436601184308529,
-0.01046003308147192,
-0.011602572165429592,
-0.0014029702870175242,
-0.035901375114917755,
0.06364001333713531,
0.022997409105300903,
0.013233897276222706,
-0.01700977422297001,
-0.01698533445596695,
-0.016924235969781876,
0.009128089994192123,
0.035290393978357315,
0.08104081451892853,
-0.04276882857084274,
0.007392897270619869,
0.002427130937576294,
-0.02319292351603508,
0.03744105249643326,
0.008602644316852093,
-0.054450828582048416,
0.012470168061554432,
-0.024683723226189613,
0.03846750408411026,
-0.048340994864702225,
0.03824755176901817,
0.0005307917017489672,
0.007093515247106552,
0.018708307296037674,
0.014235910028219223,
0.013307214714586735,
-0.00800999067723751,
0.02124999649822712,
-0.00888980645686388,
-0.06505749374628067,
-0.009378592483699322,
-0.04594593867659569,
0.01116266380995512,
0.02720097452402115,
-0.010429483838379383,
0.0034948240499943495,
0.003323748940601945,
-0.0034490004181861877,
-0.012451838701963425,
0.030353646725416183,
0.032528746873140335,
0.036512359976768494,
0.03277314081788063,
-0.016899796202778816,
-0.0017596317920833826,
0.022948531433939934,
-0.019221533089876175,
0.0209445059299469,
-0.03318861126899719,
-0.0014358105836436152,
-0.010832732543349266,
-0.003019784577190876,
0.006665827240794897,
-0.009635205380618572,
-0.017327485606074333,
0.014810234308242798,
0.005483574699610472,
-0.04697239026427269,
0.05371764674782753,
0.00844378862529993,
0.0039011279586702585,
-0.00956799741834402,
-0.05303334444761276,
0.039322882890701294,
0.023742808029055595,
0.042646631598472595,
0.04865870624780655,
0.019600342959165573,
-0.04186457023024559,
0.05630821734666824,
0.0053002797067165375,
-0.056845881044864655,
-0.003195442259311676,
0.02942495234310627,
-0.02930275723338127,
0.045530471950769424,
-0.011407056823372841,
0.0055966065265238285,
0.045970380306243896,
-0.024280473589897156,
-0.033726274967193604,
-0.022178690880537033,
-0.04276882857084274,
-0.014846893027424812,
0.060169629752635956,
-0.007056856527924538,
0.044895049184560776,
0.01759631745517254,
-0.031966641545295715,
-0.019527023658156395,
-0.02544134296476841,
0.08289820700883865,
-0.034752726554870605,
-0.02607676573097706,
-0.06627946346998215,
0.034752726554870605,
-0.034728288650512695,
0.009250286035239697,
-0.03340856358408928,
-0.05029613897204399,
-0.017938468605279922,
-0.017914028838276863,
-0.034190621227025986,
-0.05190913751721382,
-0.030671358108520508,
0.002862456487491727,
-0.01019120030105114,
0.002100254874676466,
0.0024714272003620863,
-0.002886895788833499,
-0.0093236044049263,
0.0007007214007899165,
0.039249565452337265,
0.002874676138162613,
0.02771420031785965,
-0.05161586403846741,
0.041595738381147385,
0.03509487584233284,
0.02214203216135502,
0.018048444762825966,
-0.043257612735033035,
-0.023070726543664932,
0.03773432597517967,
-0.022484183311462402,
-0.033726274967193604,
-0.005608826410025358,
-0.035363711416721344,
-0.04736342281103134,
-0.01267179287970066,
0.04262218996882439,
-0.04186457023024559,
-0.02663886919617653,
0.0597786009311676,
-0.05078492686152458,
0.015604511834681034,
-0.01700977422297001,
-0.03230879455804825,
-0.07004311680793762,
-0.023058507591485977,
-0.06955432891845703,
0.015408997423946857,
0.03797871991991997,
0.013221677392721176,
-0.01275733020156622,
-0.027323171496391296,
0.0086209736764431,
0.011468155309557915,
0.05098044127225876,
-0.029498271644115448,
-0.05190913751721382,
0.03179556876420975,
-0.026370037347078323,
0.053962040692567825,
-0.017303045839071274,
0.003849194385111332,
0.02288743294775486,
-0.00760674150660634,
0.031306780874729156,
0.0018375321524217725,
0.006476422306150198,
0.006262578070163727,
0.04171793535351753,
0.02646779455244541,
-0.01556785311549902,
-0.029180560261011124,
-0.003968336153775454,
-0.011822525411844254,
-0.012005820870399475,
0.012928405776619911,
-0.02766532078385353,
-0.009775731712579727,
0.002949521644040942,
-0.0009454965475015342,
-0.019991371780633926,
-0.027592003345489502,
0.010973258875310421,
0.001099006156437099,
-0.019832516089081764,
0.029864860698580742,
-0.031355660408735275,
-0.013673804700374603,
-0.007282920181751251,
0.028056351467967033,
0.02429269440472126,
0.0006228210404515266,
0.018476134166121483,
-0.018916040658950806,
-0.017046432942152023,
0.025661297142505646,
-0.04357532411813736,
0.013209457509219646,
0.007942781783640385,
-0.02663886919617653,
-0.0181339830160141,
-0.016496548429131508,
0.00663527799770236,
-0.004658747464418411,
0.041595738381147385,
-0.047192346304655075,
0.005178083200007677,
0.00300756492651999,
0.0030350591987371445,
0.017131969332695007,
0.07273144274950027,
-0.038198672235012054,
0.0053797075524926186,
0.02881396934390068,
0.02227644994854927,
-0.019966932013630867,
0.01188973430544138,
-0.030646920204162598,
0.005889878608286381,
-0.0664260983467102,
0.027811957523226738,
0.0013999153161421418,
-0.027298731729388237,
0.013686024583876133,
-0.023254022002220154,
-0.028985045850276947,
0.024769261479377747,
0.023009629920125008,
0.02365727163851261,
-0.02883840911090374,
0.0013189601013436913,
-0.017205288633704185,
-0.01046003308147192,
-0.03221103549003601,
-0.024561526253819466,
-0.01558007299900055,
-0.07077629864215851,
0.016215495765209198,
-0.003189332550391555,
0.027885274961590767,
0.028129668906331062,
0.02370614930987358,
-0.03394622728228569,
0.01444364432245493,
0.04685019701719284,
-0.03267538547515869,
-0.012598474510014057,
0.0025798766873776913,
0.020419059321284294,
0.01133984886109829,
0.008254383690655231,
0.030280329287052155,
0.00027837924426421523,
0.0009080738527700305,
-0.0027921933215111494,
-0.015897784382104874,
-0.027469806373119354,
0.010912160389125347,
-0.0027646992821246386,
-0.00474428478628397,
-0.02349841594696045,
-0.020443499088287354,
-0.038638580590486526,
0.022691918537020683,
-0.012494606897234917,
-0.06515525281429291,
-0.030793555080890656,
-0.013502730056643486,
0.005211687181144953,
-0.036463480442762375,
-0.030842434614896774,
0.030964631587266922,
-0.024439329281449318,
0.056259337812662125,
-0.01897713914513588,
-0.016716500744223595,
0.039274003356695175,
0.0316733717918396,
-0.005828780122101307,
-0.045506030321121216,
0.028129668906331062,
0.04633696749806404,
0.003644515061751008,
0.009128089994192123,
0.007099625188857317,
0.029058363288640976,
-0.0024867018219083548,
0.027567563578486443,
0.020113568753004074,
-0.08739504218101501,
-0.014248128980398178,
-0.05127371475100517,
-0.03384847193956375,
-0.016765380278229713,
-0.047852206975221634,
0.005333883687853813,
0.005807395558804274,
-0.008761500008404255,
0.016496548429131508,
-0.029767103493213654,
0.020162446424365044,
-0.04619033262133598,
0.035852495580911636,
-0.024744821712374687,
0.07805921882390976,
-0.04988067224621773,
0.0036597896832972765,
0.015641171485185623,
-0.022032056003808975,
-0.08622195571660995,
0.0439419150352478,
0.023388437926769257,
0.022484183311462402,
0.03827198967337608,
-0.037098903208971024,
0.038100916892290115,
0.013991516083478928,
-0.007136284373700619,
0.034215062856674194,
0.022337546572089195,
-0.0007438720786012709,
-0.01982029713690281,
0.0051597533747553825,
-0.006891890894621611,
0.02429269440472126,
0.024818139150738716,
-0.024463769048452377,
0.016997553408145905,
-0.024133838713169098,
-0.00514753395691514,
0.007698388770222664,
0.005847109481692314,
0.02122555859386921,
0.021335534751415253,
-0.030304769054055214,
0.0495629608631134,
0.024708162993192673,
0.07004311680793762,
-0.023302901536226273,
0.015176823362708092,
-0.013637145981192589,
-0.027592003345489502,
-0.010826623067259789,
-0.0344838947057724,
0.012396849691867828,
0.021115580573678017,
-0.027494246140122414,
0.01003845501691103,
0.023974983021616936,
0.009739072993397713,
0.009598546661436558,
-0.011883623898029327,
0.02876509167253971,
-0.026198960840702057,
-0.018170641735196114,
-0.01660652458667755,
-0.012256324291229248,
0.031893324106931686,
-0.006891890894621611,
-0.004234113730490208,
-0.020272424444556236,
0.009048662148416042,
-0.008346031419932842,
-0.030989069491624832,
0.035901375114917755,
0.004429628606885672,
0.007368457969278097,
0.06466646492481232,
-0.0075212037190794945,
0.07219377905130386,
0.043306492269039154,
0.016765380278229713,
0.014626938849687576,
-0.03558366373181343,
-0.005040611606091261,
-0.03296865522861481,
0.013221677392721176,
0.01203025970607996,
-0.003088520374149084,
0.0035559225361794233,
0.020626794546842575,
-0.04863426461815834,
0.007692278828471899,
0.008315482176840305,
0.05073604732751846,
-0.01609329879283905,
0.031428977847099304,
-0.007563972380012274,
-0.0298893004655838,
0.061342716217041016,
-0.04347756877541542,
0.030866874381899834,
0.03392178937792778,
-0.014040394686162472,
0.02935163490474224,
-0.03223547711968422,
0.005098655354231596,
-0.02148217149078846,
0.05924093723297119,
0.029205000028014183,
-0.013404972851276398,
-0.018231740221381187,
-0.050027307122945786,
0.05078492686152458,
0.00007336572161875665,
-0.017400803044438362,
0.007270700763911009,
0.0360235720872879,
-0.037538811564445496,
0.010649438016116619,
-0.033066414296627045,
-0.002034574281424284,
-0.02830074355006218,
0.017303045839071274,
0.013869320042431355,
-0.014480303041636944,
0.047119028866291046,
-0.01815842278301716,
0.0385652631521225,
0.009977356530725956,
-0.056845881044864655,
0.0009271670714952052,
-0.03047584369778633,
-0.01897713914513588,
0.0030396415386348963,
0.027836397290229797,
-0.04907417297363281,
0.02002803049981594,
0.018537230789661407,
-0.07282920181751251,
0.00633589643985033,
0.015616731718182564,
0.022716356441378593,
0.0009959026938304305,
0.015470095910131931,
-0.05386428162455559,
-0.006494751665741205,
0.05880102887749672,
0.03328636661171913,
-0.0005968542536720634,
0.0009057826828211546,
-0.020748991519212723,
0.03663455694913864,
-0.0002873530611395836,
-0.016899796202778816,
0.005077270790934563,
-0.01125431153923273,
0.06432431936264038,
-0.024402670562267303,
0.03631684556603432,
0.03851638361811638,
-0.005175027996301651,
0.02480592019855976,
-0.02087118849158287,
-0.019575903192162514,
-0.008132186718285084,
0.05616157874464989,
0.02250862307846546,
-0.012769550085067749,
0.014358106069266796,
-0.050589412450790405,
0.06368889659643173,
-0.010673876851797104,
0.007362348027527332,
0.011682000011205673,
-0.011694218963384628,
-0.013404972851276398,
-0.015433437190949917,
-0.0021827376913279295,
-0.018195081502199173,
0.0114314965903759,
0.01327055599540472,
0.014529181644320488,
0.015115725807845592,
0.0074906544759869576,
0.0086209736764431,
0.04298878088593483,
0.0036048011388629675,
-0.011040466837584972,
0.042084526270627975,
-0.026956580579280853,
0.00863319355994463,
-0.029620468616485596,
-0.0009691721643321216,
0.020296864211559296,
0.004640417639166117,
-0.04474841430783272,
-0.00514753395691514,
-0.03783208131790161,
-0.030891312286257744,
0.003464275039732456,
0.020296864211559296,
-0.016997553408145905,
-0.01719306781888008,
-0.027249852195382118,
-0.007484544534236193,
0.02768976055085659,
0.01752300001680851,
-0.007399007212370634,
-0.010887721553444862,
-0.03880965709686279,
0.00500089768320322,
0.036463480442762375,
-0.021897640079259872,
0.021005604416131973,
0.012610694393515587,
-0.007417336571961641,
0.005263620521873236,
-0.05665036663413048,
-0.004799273330718279,
-0.019759198650717735,
-0.03282202035188675,
0.01588556356728077,
-0.0012700813822448254,
-0.002259110566228628,
0.00009107468940783292,
0.024500427767634392,
-0.009256396442651749,
0.01522570289671421,
-0.01815842278301716,
0.0242682546377182,
-0.000507497985381633,
0.024439329281449318,
-0.017351923510432243,
0.011541473679244518,
0.006030404474586248,
0.019575903192162514,
-0.02878952957689762,
-0.0015633533475920558,
-0.05142034962773323,
-0.017926247790455818,
-0.033115290105342865,
-0.01352716889232397,
-0.009616876021027565,
0.0027341500390321016,
-0.01721750758588314,
-0.010961038991808891,
-0.003589526517316699,
0.018268398940563202,
-0.01787737011909485,
-0.02935163490474224,
0.022618599236011505,
-0.041009195148944855,
0.0123235322535038,
-0.025856811553239822,
-0.005853219423443079,
0.04990511015057564,
-0.007722828071564436,
-0.03340856358408928,
0.02495255507528782,
0.011999710462987423,
-0.005752407480031252,
-0.016154397279024124,
-0.03880965709686279,
-0.01301394309848547,
0.051127076148986816,
0.00010701753490138799,
0.0072157122194767,
-0.0480232834815979,
0.0014732333365827799,
-0.0013518003979697824,
0.03228435292840004,
0.023107387125492096,
0.0004231058992445469,
0.04311097785830498,
0.013624926097691059,
-0.023327339440584183,
0.023412877693772316,
0.013221677392721176,
-0.013942637480795383,
-0.019575903192162514,
-0.005847109481692314,
0.0034245611168444157,
-0.009225847199559212,
0.0026379202026873827,
-0.02431713230907917,
-0.01867164857685566,
0.036439042538404465,
0.006616948638111353,
0.005306389648467302,
-0.008291042409837246,
-0.0023629777133464813,
0.03563254326581955,
0.04298878088593483,
0.026956580579280853,
-0.01089383102953434,
0.05489073321223259,
0.03101350925862789,
-0.01862276904284954,
-0.04809660091996193,
0.020370181649923325,
-0.014871331863105297,
-0.018659427762031555,
0.00030205483199097216,
-0.011846965178847313,
0.00720349233597517,
0.0158366858959198,
-0.04814548045396805,
-0.020480157807469368,
0.00948856957256794,
0.029864860698580742,
-0.011144334450364113,
-0.0061617661267519,
-0.034190621227025986,
0.004032489378005266,
0.03277314081788063,
-0.009537448175251484,
-0.026761066168546677,
0.038614142686128616,
-0.0026058435905724764,
-0.011242091655731201,
0.037636566907167435,
-0.036561235785484314,
-0.003956116735935211,
-0.007942781783640385,
-0.018268398940563202,
0.041669055819511414,
-0.021298876032233238,
-0.016227714717388153,
-0.009616876021027565,
0.014504741877317429,
-0.0028257975354790688,
-0.014260348863899708,
-0.02127443626523018,
0.028594015166163445,
0.006665827240794897,
-0.007111845072358847,
-0.014370325952768326,
-0.009641315788030624,
0.016643183305859566,
0.05327773839235306,
0.08011212199926376,
-0.013319434598088264,
0.022264229133725166,
-0.009152528829872608,
-0.0016038310714066029,
-0.021005604416131973,
0.008089418523013592,
0.004921469837427139,
-0.01588556356728077,
0.010142321698367596,
0.027836397290229797,
0.11818859726190567,
0.006021239794790745,
0.022129813209176064,
-0.029205000028014183,
-0.014113713055849075,
-0.024842578917741776,
-0.001591611304320395,
-0.01609329879283905,
-0.011987491510808468,
0.0010837315348908305,
-0.01639878936111927,
0.006751365028321743,
-0.033604077994823456,
-0.05220240727066994,
-0.006180095486342907,
0.0022652202751487494,
0.0034245611168444157,
0.0018619714537635446,
0.005801286082714796,
0.023852786049246788,
-0.010496691800653934,
-0.0332130491733551,
-0.027958592399954796,
-0.03401954844594002,
0.01897713914513588,
-0.007618960924446583,
0.015946662053465843,
-0.024561526253819466,
0.0030426965095102787,
-0.026394475251436234,
0.03370183706283569,
-0.013747123070061207,
0.042597752064466476,
-0.02403608150780201,
0.03318861126899719,
-0.02881396934390068,
-0.010661657899618149,
-0.0416446179151535,
0.014639158733189106,
0.01044781319797039,
-0.0028914781287312508,
-0.0003870197106152773,
-0.0012158566387370229,
-0.06305347383022308,
-0.04249999299645424,
0.022716356441378593,
-0.012574034743010998,
0.05435306951403618,
0.013123920187354088,
0.019527023658156395,
-0.002929664682596922,
0.0360235720872879,
-0.0316733717918396,
-0.02881396934390068,
0.029864860698580742,
0.04477285221219063,
-0.030280329287052155,
0.05034501850605011,
-0.024683723226189613,
-0.02595456875860691,
0.019026018679142,
0.009195297956466675,
-0.008358250372111797,
-0.016826478764414787,
-0.005905153229832649,
0.03739217296242714,
-0.016997553408145905,
-0.028691772371530533,
-0.01388153899461031,
0.007075185887515545,
0.0051047648303210735,
-0.04731454327702522,
-0.06100056692957878,
0.023865005001425743,
-0.002537108026444912,
0.009403032250702381,
0.03521707281470299,
0.013747123070061207,
-0.02944939211010933,
0.009176968596875668,
0.01522570289671421,
0.009421361610293388,
-0.01298950333148241,
-0.014773574657738209,
-0.008425459265708923,
-0.042695507407188416,
0.013832660391926765,
0.002075815573334694,
-0.02340065874159336,
-0.02837406098842621,
-0.013832660391926765,
0.007777816615998745,
0.018818283453583717,
-0.011651450768113136,
-0.00733790872618556,
0.003516208613291383,
0.009525229223072529,
-0.00015160022303462029,
0.010747195221483707,
-0.018243959173560143,
-0.009445801377296448,
-0.02398720197379589,
0.028007471933960915,
-0.009622986428439617,
-0.01158424187451601,
0.008755389600992203,
-0.01721750758588314,
0.008474337868392467,
-0.01744968071579933,
0.020064689218997955,
0.004997842945158482,
0.01573892869055271,
-0.014822453260421753,
-0.002807467943057418,
-0.018549451604485512,
0.02140885218977928,
0.007179053034633398,
0.009824610315263271,
-0.03954283520579338,
-0.005853219423443079,
-0.007130174431949854,
0.02066345326602459,
-0.030695797875523567,
-0.016411010175943375,
0.0031862775795161724,
0.025013653561472893,
0.033066414296627045,
-0.0850488692522049,
-0.023645050823688507,
-0.02766532078385353,
-0.03455721214413643,
-0.028569577261805534,
-0.00023618321574758738,
-0.016533207148313522,
-0.027445366606116295,
0.001140247448347509,
-0.015751147642731667,
0.027469806373119354,
-0.01698533445596695,
0.01859832927584648,
0.026150083169341087,
-0.004169960506260395,
0.016618743538856506,
-0.00720349233597517,
-0.0424022376537323,
-0.017205288633704185,
0.00778392655774951,
0.026052325963974,
-0.012903966009616852,
-0.011235982179641724,
0.07497986406087875,
0.008089418523013592,
0.01196916215121746,
-0.020480157807469368,
0.008242163807153702,
-0.011180993169546127,
-0.008547655306756496,
0.05699251592159271,
0.03045140579342842,
-0.014125932939350605,
0.023107387125492096,
0.01352716889232397,
-0.01691201701760292,
0.023388437926769257,
-0.03179556876420975,
-0.012940624728798866,
-0.002312571508809924,
-0.015054627321660519,
0.004004995338618755,
0.010044564493000507,
-0.000022172009266796522,
0.0041852351278066635,
0.010429483838379383,
-0.036390163004398346,
0.0063297864980995655,
0.010508911684155464,
-0.015152384527027607,
0.024194937199354172,
-0.006293127313256264,
-0.02593012899160385,
0.007759487256407738,
-0.007136284373700619,
0.00760674150660634,
0.011779757216572762,
0.01913599483668804,
0.022435305640101433,
0.02089562639594078,
-0.0298893004655838,
0.041669055819511414,
0.0121341273188591,
-0.008119967766106129,
-0.005526343360543251,
-0.016863137483596802,
-0.05132259428501129,
0.009305275045335293,
-0.028056351467967033,
0.006228974089026451,
-0.02089562639594078,
0.000440289790276438,
-0.020675672218203545,
0.027934154495596886,
0.0014640686567872763,
0.03370183706283569,
-0.011223762296140194,
0.02059013582766056,
0.007912233471870422,
-0.00011179083958268166,
-0.016924235969781876,
-0.0009378592949360609,
-0.04196232929825783,
0.002850236836820841,
-0.029815983027219772,
-0.02768976055085659,
0.015604511834681034,
0.0068430122919380665,
0.00793056283146143,
0.02316848374903202,
-0.010007905773818493,
-0.008926465176045895,
-0.04423518851399422,
-0.005016172304749489,
-0.001719917869195342,
-0.012305202893912792,
-0.0544019490480423,
-0.007967221550643444,
-0.01048447284847498,
-0.02996261790394783,
0.042182281613349915,
-0.04465065523982048,
0.011761427856981754,
0.00535221304744482,
-0.01417481154203415,
-0.028178546577692032,
0.025196949020028114,
-0.03389735147356987,
-0.001068456913344562,
-0.022154252976179123,
0.030769115313887596,
-0.014736915938556194,
0.03467940911650658,
0.005483574699610472,
0.004386859480291605,
0.006794133689254522,
0.004197455011308193,
0.009940697811543941,
0.036487918347120285,
-0.014492522925138474,
0.05132259428501129,
0.016288813203573227,
0.001646599848754704,
-0.009317494928836823,
0.001840587006881833,
-0.00183447718154639,
0.010802184231579304,
0.005905153229832649,
0.011388727463781834,
0.0298893004655838,
0.024353792890906334,
0.015592291951179504,
-0.010380605235695839,
-0.006488642189651728,
-0.0006743727717548609,
0.0480232834815979,
-0.013185018673539162,
0.03609688952565193,
0.000974518246948719,
0.024146057665348053,
-0.015470095910131931,
0.0010592922335490584,
-0.01188973430544138,
0.010148432105779648,
0.022484183311462402,
-0.017694074660539627,
-0.029644906520843506,
0.040447089821100235,
-0.018806064501404762,
0.035974692553281784,
-0.008504887111485004,
0.02204427495598793,
0.001123445457778871,
0.025661297142505646,
0.008101637475192547,
0.03739217296242714,
-0.0004895503516308963,
-0.027543123811483383,
-0.023889444768428802,
0.021347753703594208,
-0.017816271632909775,
0.06398216634988785,
-0.010020125657320023,
-0.03062248043715954,
0.02176322229206562,
-0.010502802208065987,
-0.0018909930950030684,
0.0004379986203275621,
0.021860981360077858,
0.01415037177503109,
0.01413815189152956,
-0.06432431936264038,
0.024610405787825584,
-0.018757184967398643,
-0.0191604346036911,
0.0005315554444678128,
0.02459818497300148,
0.02434157207608223,
0.018793843686580658,
0.013905978761613369,
-0.021078921854496002,
0.00325654074549675,
-0.0029877079650759697,
0.041009195148944855,
-0.0020788705442100763,
-0.009317494928836823,
-0.02935163490474224,
-0.03221103549003601,
0.000986737897619605,
0.003931676968932152,
-0.013478290289640427,
-0.019123775884509087,
0.02497699484229088,
0.04577486589550972,
0.06671936810016632,
-0.02347397617995739,
-0.020015811547636986,
0.05322885885834694,
-0.04071592167019844,
-0.03614576905965805,
-0.04232892021536827,
-0.00039866656879894435,
0.03560810536146164,
0.00720349233597517,
-0.012708451598882675,
0.032993096858263016,
0.020186886191368103,
-0.02891172654926777,
-0.01529902033507824,
0.0362679660320282,
0.006005965173244476,
0.028520697727799416,
-0.03387290984392166,
0.02122555859386921,
0.01573892869055271,
-0.020761210471391678,
0.00800999067723751,
0.014712476171553135,
-0.0011517034145072103,
-0.02778751775622368,
-0.026443354785442352,
-0.02888728864490986,
-0.00528195034712553,
0.00431048683822155,
0.018806064501404762,
0.01941704750061035,
0.04223116114735603,
0.004725955426692963,
-0.014468083158135414,
0.022190911695361137,
-0.0021231668069958687,
0.018072884529829025,
0.013844880275428295,
-0.00173671985976398,
-0.0047870539128780365,
0.0027708089910447598,
-0.016520986333489418,
-0.02610120363533497,
-0.028105229139328003,
-0.0021903750021010637,
0.05073604732751846,
-0.012256324291229248,
0.008975343778729439,
-0.0293760746717453,
-0.013576047495007515,
-0.012073028832674026,
0.019893614575266838,
-0.034654971212148666,
-0.017962906509637833,
-0.01503018755465746,
-0.004927579779177904,
0.01555563323199749,
0.006708595901727676,
0.017388582229614258,
0.016814259812235832,
0.004548770375549793,
-0.0075212037190794945,
0.03453277423977852,
0.016007760539650917,
-0.008229943923652172,
-0.015164604410529137,
0.016545426100492477,
0.010863281786441803,
-0.03169780969619751,
0.011425387114286423,
0.008565984666347504,
0.0027081831358373165,
-0.00878593884408474,
-0.007130174431949854,
0.020174667239189148,
0.0006388593465089798,
0.007154613733291626,
-0.0016695116646587849,
-0.025905689224600792,
0.0005716512096114457,
-0.012696231715381145,
0.016569865867495537,
-0.00751509377732873,
0.006751365028321743,
0.015152384527027607,
-0.003873633686453104,
0.0015022550942376256,
-0.01382044143974781,
0.014920210465788841,
0.02429269440472126,
0.023351779207587242,
-0.037538811564445496,
-0.027567563578486443,
-0.026345597580075264,
-0.023021848872303963,
-0.03450833261013031,
0.029571589082479477,
-0.0010058311745524406,
-0.007716718595474958,
-0.011950831860303879,
-0.01836615614593029,
-0.016997553408145905,
-0.0012739000376313925,
-0.010612779296934605,
0.02452486753463745,
0.007032417226582766,
0.033090852200984955,
0.010631108656525612,
-0.01441920455545187,
0.029156120494008064,
-0.010172870941460133,
-0.01986917480826378,
-0.02551466040313244,
0.022361986339092255,
-0.006311457138508558,
-0.03238211199641228,
0.01606885902583599,
-0.00851710606366396,
-0.013514949008822441,
-0.002874676138162613,
0.002185792662203312,
-0.0020865078549832106,
0.013490510173141956,
0.004072203300893307,
0.003571197157725692,
-0.006146491505205631,
0.007331798784434795,
-0.0013029217952862382,
-0.018537230789661407,
-0.024915896356105804,
0.001111225807107985,
0.018207300454378128,
0.016081079840660095,
-0.01380822155624628,
-0.021653246134519577,
0.044381823390722275,
-0.005178083200007677,
0.004056928679347038,
-0.011388727463781834,
0.003956116735935211,
0.017742954194545746,
-0.017229728400707245,
0.02434157207608223,
0.011718658730387688,
-0.017938468605279922,
0.018867162987589836,
0.02497699484229088,
0.012170786038041115,
0.010233969427645206,
0.025856811553239822,
-0.0029632686637341976,
0.018243959173560143,
-0.03680562973022461,
-0.01273289043456316,
-0.003180167870596051,
0.059680841863155365,
-0.0355103462934494,
-0.039836108684539795,
0.03230879455804825,
0.0007851134869270027,
-0.012500717304646969,
-0.00602734973654151,
0.014345886185765266,
0.0017535219667479396,
0.01665540412068367,
-0.011235982179641724,
0.07410004734992981,
0.05366876721382141,
-0.017303045839071274,
0.035412587225437164,
0.023266242817044258,
-0.0219709575176239,
0.0011433024192228913,
0.021567707881331444,
0.020773429423570633,
0.02150660939514637,
0.008706510998308659,
0.004860371816903353,
0.005385817494243383,
-0.02342509850859642,
0.005251401104032993,
0.04012937843799591,
0.019270410761237144,
-0.00636644521728158,
0.05254456028342247,
-0.003280980046838522,
-0.003910292871296406,
-0.002275912556797266,
-0.023510634899139404,
0.005538563244044781,
-0.019270410761237144,
-0.010570010170340538,
-0.03355519846081734,
0.02038240060210228,
-0.02059013582766056,
-0.0016114682657644153,
-0.011260421015322208,
0.004319651518017054,
0.020626794546842575,
-0.03289533779025078,
-0.004637362901121378,
-0.006180095486342907,
0.009519118815660477,
0.0076006315648555756,
-0.005709638353437185,
-0.017926247790455818,
-0.02651667222380638,
0.02140885218977928,
-0.016178837046027184,
0.02084674872457981,
0.011553693562746048,
0.005193357355892658,
-0.0075212037190794945,
0.006696376483887434,
0.017559658735990524,
-0.02815410867333412,
0.008003880269825459,
-0.044332943856716156,
-0.005126149393618107,
-0.0037636568304151297,
-0.005398036912083626,
-0.011003808118402958,
-0.007557862903922796,
-0.031893324106931686,
0.009409141726791859,
-0.011755317449569702,
-0.005153643898665905,
-0.010221749544143677,
-0.002095672534778714,
-0.02452486753463745,
-0.0016099408967420459,
0.02935163490474224,
0.006580289453268051,
-0.032504308968782425,
-0.001356382854282856,
0.0008912718039937317,
0.017559658735990524,
0.016227714717388153,
0.031282342970371246,
-0.02778751775622368,
0.002196484711021185,
-0.0002459207607898861,
0.018525011837482452,
-0.005428586155176163,
0.018231740221381187,
0.012427398934960365,
-0.0003663990064524114,
0.03690338879823685,
-0.012103578075766563,
0.010325617156922817,
-0.008688181638717651,
-0.02424381487071514,
-0.02342509850859642,
0.037636566907167435,
0.0071179550141096115,
0.012647353112697601,
0.013796001672744751,
-0.025710174813866615,
-0.03353076055645943,
-0.006293127313256264,
-0.0047565046697855,
-0.023461757227778435,
-0.011413167230784893,
0.013417191803455353,
0.025074752047657967,
-0.03797871991991997,
-0.010148432105779648,
0.00694687943905592,
0.02342509850859642,
0.020700111985206604,
0.006073173601180315,
-0.01556785311549902,
-0.01705865189433098,
-0.012855087406933308,
0.005068106111139059,
0.014370325952768326,
0.0012616803869605064,
0.027567563578486443,
0.012305202893912792,
0.04413742944598198,
-0.05278895050287247,
0.03338412567973137,
0.02544134296476841,
0.028031911700963974,
0.023632831871509552,
-0.04245111718773842,
0.0006613893783651292,
-0.015103505924344063,
-0.007747267372906208,
0.018219521269202232,
0.011547583155333996,
-0.01573892869055271,
-0.01752300001680851,
0.0446995347738266,
-0.0005078798276372254,
-0.01529902033507824,
-0.010576119646430016,
-0.009775731712579727,
-0.009696303866803646,
-0.0030014552175998688,
-0.028691772371530533,
-0.001924597192555666,
-0.03235767409205437,
0.006342005915939808,
0.021372193470597267,
-0.014834673143923283,
-0.029522709548473358,
-0.003934732172638178,
-0.03546146675944328,
0.02173878438770771,
0.01562895067036152,
-0.02940051443874836,
-0.04970959573984146,
-0.01036838535219431,
0.000610983232036233,
-0.028985045850276947,
-0.022264229133725166,
-0.008957014419138432,
0.00933582428842783,
0.03155117481946945,
-0.030793555080890656,
-0.004869536496698856,
0.02935163490474224,
0.027836397290229797,
-0.005422476213425398,
0.022814113646745682,
0.021922077983617783,
0.010276738554239273,
-0.01933150924742222,
-0.01900157891213894,
-0.0005418657674454153,
-0.005828780122101307,
0.03680562973022461,
-0.028520697727799416,
0.015433437190949917,
0.020541256293654442,
-0.01818286068737507,
0.033750712871551514,
-0.0051383692771196365,
-0.03279757872223854,
0.03340856358408928,
-0.01273289043456316,
-0.0209445059299469,
-0.013796001672744751,
-0.008871477097272873,
-0.014834673143923283,
0.023535074666142464,
0.01637435145676136,
0.0015480788424611092,
0.004328816197812557,
0.00237825233489275,
0.036390163004398346,
-0.01642322912812233,
-0.03607245162129402,
0.0065130814909935,
0.05469521880149841,
-0.013979296199977398,
0.00009966664219973609,
0.02539246343076229,
-0.01611773855984211,
-0.04682575538754463,
-0.012952844612300396,
-0.012940624728798866,
-0.01382044143974781,
-0.007692278828471899,
-0.01883050426840782,
-0.007240151520818472,
-0.006152601446956396,
0.027274291962385178,
-0.0038186453748494387,
0.0007114136242307723,
-0.025050312280654907,
0.007557862903922796,
-0.019453706219792366,
0.005257511045783758,
-0.010875501669943333,
-0.023510634899139404,
-0.02778751775622368,
-0.0025569649878889322,
-0.020541256293654442,
0.0034673300106078386,
0.009421361610293388,
0.005819615442305803,
-0.02406051941215992,
-0.02710321731865406,
-0.022447524592280388,
-0.01803622581064701,
-0.025685735046863556,
-0.005523288622498512,
-0.006409214343875647,
-0.0010142321698367596,
-0.030964631587266922,
-0.009470240212976933,
0.0009294582414440811,
-0.00255391001701355,
-0.04262218996882439,
0.003171002957969904,
-0.022239789366722107,
-0.019148215651512146,
0.03343300148844719,
0.026443354785442352,
-0.021958738565444946,
0.004124137107282877,
-0.05034501850605011,
0.002839544555172324,
-0.021078921854496002,
0.028471820056438446,
0.026418915018439293,
0.005734077654778957,
-0.016411010175943375,
0.00015035916294436902,
-0.015922224149107933,
-0.036487918347120285,
-0.023046288639307022,
0.013087261468172073,
-0.013111700303852558,
0.006018185056746006,
-0.011602572165429592,
-0.006140381563454866,
0.009830720722675323,
0.016973113641142845,
-0.03854082152247429,
0.003430670825764537,
0.00904255174100399,
0.025196949020028114,
0.001213565468788147,
0.05220240727066994,
-0.02204427495598793,
-0.0017397748306393623,
-0.008938685059547424,
0.05757905915379524,
-0.038711898028850555,
-0.014492522925138474,
0.05088268592953682,
0.002724985359236598,
-0.01389375887811184,
0.02832518331706524,
0.029131680727005005,
-0.03668343275785446,
-0.014040394686162472,
-0.021958738565444946,
-0.014248128980398178,
0.014333667233586311,
-0.038125354796648026,
0.020467938855290413,
-0.007557862903922796,
0.01859832927584648,
0.020773429423570633,
0.0005582859157584608,
-0.021372193470597267,
0.03164893388748169,
-0.013686024583876133,
-0.02457374520599842,
-0.013832660391926765,
-0.001579391653649509,
-0.032504308968782425,
0.006806353572756052,
-0.001967366086319089,
0.03617020696401596,
0.019502585753798485,
0.027494246140122414,
-0.012635133229196072,
0.006800243631005287,
-0.026883263140916824,
-0.011694218963384628,
0.009451910853385925,
-0.013576047495007515,
-0.003280980046838522,
0.05249568074941635,
0.029547149315476418,
-0.003117542015388608,
0.031991083174943924,
0.007838915102183819,
-0.0015228757401928306,
0.010356166400015354,
-0.025025874376296997,
0.006531410850584507,
-0.011981381103396416,
-0.002326318761333823,
0.11926393210887909,
0.0036475700326263905,
0.023082947358489037,
0.02087118849158287,
-0.003977500833570957,
0.0007461633067578077,
-0.007869464345276356,
-0.01444364432245493,
0.009060881100594997,
-0.02935163490474224,
0.027494246140122414,
0.04012937843799591,
0.030793555080890656,
0.024634843692183495,
0.009873488917946815,
-0.018854942172765732,
0.020700111985206604,
0.016056640073657036,
-0.008144406601786613,
-0.011938612908124924,
-0.004139411263167858,
0.0015824466245248914,
-0.043330930173397064,
0.01355160865932703,
-0.02996261790394783,
-0.023926103487610817,
0.01839059591293335,
0.0037147782277315855,
-0.005724912974983454,
-0.024708162993192673,
0.02459818497300148,
0.027298731729388237,
0.02007691003382206,
-0.02373058907687664,
-0.01749856024980545,
0.016533207148313522,
-0.02646779455244541,
-0.0288628488779068,
0.004191345069557428,
-0.0034703847486525774,
0.00452738581225276,
0.025905689224600792,
-0.020443499088287354,
-0.019343730062246323,
0.00457931961864233,
-0.007124064490199089,
-0.03912736847996712,
0.0025630746968090534,
0.008572095073759556,
-0.030109254643321037,
0.011908063665032387,
-0.015518974512815475,
0.020064689218997955,
-0.00959243718534708,
-0.024634843692183495,
-0.01388153899461031,
0.00601512985303998,
0.017840711399912834,
-0.0027708089910447598,
-0.022569721564650536,
-0.007912233471870422,
0.016459887847304344,
0.003540647914633155,
0.011058797128498554,
-0.0016099408967420459
] | 2025-01-22 | 1 | 39840882 | [
"marginal zone lymphoma",
"holding therapy",
"early referral",
"complete remission",
"diffuse large B-cell lymphoma",
"patients",
"disease",
"BCL6 rearrangements",
"CAR-T cells",
"Chimeric Antigen Receptor T cell (CAR-T) therapy",
"CAR-T treatment",
"infusion",
"centers",
"High-grade B-cell lymphoma",
"a combined bridging therapy",
"apheresis",
"diagnosis",
"BCL6",
"MYC",
"prognosis",
"a metabolic complete remission",
"the CAR-T center",
"a correct referral",
"Patient",
"Success",
"DLBCL",
"the lymphocyte collection",
"a short time",
"The patient",
"a patient"
] | [] | 0 | 10.1701/4416.44128 | [
"Tisi"
] | [
"UO Ematologia, Ospedale San Bortolo, Vicenza."
] | [
"39840882"
] | [] | 6.266233 | 5.473475 |
39839908 | 7 | A bioluminescent reporter bioassay for in-process assessment of chimeric antigen receptor lentiviral vector potency. | Chimeric antigen receptor (CAR)-T-cell therapy is a breakthrough in the field of cancer immunotherapy, wherein T cells are genetically modified to recognize and attack cancer cells. Delivery of the CAR gene is a critical step in this therapy and is usually achieved by transducing patient T cells with a lentiviral vector (LV). Because the LV is an essential component of CAR-T manufacturing, there is a need for simple bioassays that reflect the mechanism of action (MOA) of the LV and can measure LV potency with accuracy and specificity. Common methods for LV quantification may overestimate functional titer and lack a functional readout of LV MOA.
We developed a bioluminescent reporter bioassay using Jurkat T cells stably expressing a luciferase reporter under the control of an nuclear factor of activated T cells (NFAT) response element and tested its suitability for measuring LV potency.
Jurkat reporter cells can be transduced with CAR LV and combined with target cells, yielding a luminescent signal that is dependent on the identity and potency of the LV used. Bioluminescence was highly correlated with CAR expression. The assay is stability indicating and suitable for use in drug development and quality control settings.
We have developed a simple bioassay for potency testing of CAR LV. The bioassay represents a significant improvement over other approaches to LV quantification because it reflects the MOA of the LV and selectively detects fully functional viral particles, making it ideal for inclusion in a matrix of in-process quality control assays for CAR LV. | [
-0.0014690025709569454,
-0.01320493035018444,
-0.009483763948082924,
0.024350037798285484,
-0.019641874358057976,
-0.029156289994716644,
-0.021763000637292862,
-0.019090136513113976,
0.017398139461874962,
-0.022400563582777977,
-0.007086768746376038,
0.00039617856964468956,
-0.04404095560312271,
-0.00358629715628922,
0.02023039385676384,
-0.06547291576862335,
0.01282484456896782,
-0.02227795496582985,
0.013719885610044003,
0.005244576372206211,
0.028028292581439018,
-0.025502558797597885,
0.00172418134752661,
0.013253973796963692,
-0.015215708874166012,
-0.04426165297627449,
0.011304499581456184,
-0.012996495701372623,
-0.020316220819950104,
-0.040926702320575714,
0.021861087530851364,
-0.017373617738485336,
-0.016012663021683693,
-0.018035704270005226,
-0.02773403190076351,
0.04433521628379822,
0.059097275137901306,
-0.004279035143554211,
-0.013082321733236313,
-0.017201965674757957,
0.001834528986364603,
0.0024414407089352608,
0.021701695397496223,
0.06895499676465988,
-0.028665855526924133,
0.007963418960571289,
-0.016233358532190323,
-0.018710050731897354,
-0.020696306601166725,
0.029278898611664772,
-0.03928374871611595,
0.01906561478972435,
-0.00856420025229454,
0.02100282721221447,
-0.044065479189157486,
0.012303758412599564,
-0.025821339339017868,
0.008276070468127728,
-0.018109267577528954,
0.04332982748746872,
0.02851872518658638,
0.023025866597890854,
0.01680961810052395,
-0.021015089005231857,
-0.06566908955574036,
0.00837415736168623,
-0.048651035875082016,
-0.010041632689535618,
0.0393327921628952,
0.030357852578163147,
0.050808943808078766,
0.03558097407221794,
-0.00036648433888331056,
-0.015571273863315582,
0.023504041135311127,
0.02552708052098751,
-0.023454997688531876,
0.038817837834358215,
0.0035587104503065348,
0.007215507328510284,
0.044850170612335205,
0.00641242228448391,
-0.02325882390141487,
-0.04546321555972099,
0.016368228942155838,
-0.013523712754249573,
0.026140121743083,
-0.04073052853345871,
-0.021799782291054726,
-0.02210630476474762,
0.0007647702004760504,
0.03207436949014664,
-0.052917808294296265,
0.04038722440600395,
-0.013180408626794815,
0.023675691336393356,
-0.02736620604991913,
-0.045340605080127716,
0.02172621712088585,
0.05478145554661751,
0.05713553726673126,
0.03207436949014664,
0.02530638501048088,
-0.017827268689870834,
0.05090703070163727,
0.03786148875951767,
-0.040926702320575714,
0.0038407098036259413,
0.02016909047961235,
-0.03001454845070839,
0.09386903047561646,
-0.0029870483558624983,
0.0010023240465670824,
0.05301589518785477,
0.008613243699073792,
-0.049926161766052246,
-0.0060844444669783115,
0.00014416071644518524,
0.008846200071275234,
-0.017925355583429337,
-0.04435973986983299,
0.017753703519701958,
0.07381028681993484,
-0.03553193062543869,
0.024325517937541008,
-0.04077957198023796,
0.05581136792898178,
-0.009606372565031052,
-0.012506062164902687,
-0.02790568396449089,
-0.017165184020996094,
-0.0011203347239643335,
0.05134842172265053,
-0.020365264266729355,
-0.044408783316612244,
-0.00906689465045929,
-0.00969832856208086,
-0.01397736370563507,
-0.05934249237179756,
-0.019384397193789482,
0.016662489622831345,
0.011138977482914925,
0.007932767271995544,
0.009771893732249737,
-0.04090217873454094,
-0.04011748731136322,
-0.030529504641890526,
0.05409485101699829,
0.024963080883026123,
0.024325517937541008,
-0.023920908570289612,
0.019212745130062103,
0.010268458165228367,
0.0018406594172120094,
-0.0040920572355389595,
-0.03636566549539566,
-0.00801246240735054,
0.05022042244672775,
-0.051544591784477234,
-0.040975745767354965,
0.006351117976009846,
0.027120988816022873,
-0.0035525800194591284,
-0.007019334007054567,
-0.0163069237023592,
-0.015951359644532204,
-0.008588721975684166,
0.002021506894379854,
-0.06846456229686737,
0.010783413425087929,
-0.0359242781996727,
-0.011378064751625061,
-0.005097446497529745,
-0.056841280311346054,
-0.05698841065168381,
-0.025453515350818634,
0.013241712935268879,
0.03690514340996742,
-0.01977674290537834,
-0.02371247485280037,
-0.006200922653079033,
0.00724002905189991,
0.028886551037430763,
-0.024166125804185867,
0.022976823151111603,
0.01802344247698784,
-0.027120988816022873,
0.05998005345463753,
-0.049215033650398254,
-0.07042629271745682,
-0.017263270914554596,
0.034011583775281906,
0.04641956090927124,
0.03168202564120293,
-0.005931183695793152,
-0.01492144912481308,
0.045732952654361725,
0.02900915965437889,
-0.020684046670794487,
-0.04941120743751526,
-0.012076932936906815,
0.010133588686585426,
-0.01586553454399109,
-0.04845486208796501,
-0.010145849548280239,
-0.004413904156535864,
-0.018881700932979584,
0.033349499106407166,
-0.004444556310772896,
-0.011267716996371746,
0.05301589518785477,
0.03342306241393089,
-0.017888573929667473,
0.014798840507864952,
-0.023454997688531876,
0.024999864399433136,
0.012849366292357445,
0.05718458071351051,
0.025232819840312004,
0.024386821314692497,
-0.02790568396449089,
0.0033196238800883293,
-0.008214766159653664,
-0.006829290650784969,
-0.06679708510637283,
0.0063940309919416904,
0.015375100076198578,
-0.05389867722988129,
0.01879587583243847,
-0.06473726034164429,
0.0029058202635496855,
0.005321206990629435,
-0.02314847521483898,
-0.014553623273968697,
-0.019985178485512733,
0.0077917673625051975,
0.03906305134296417,
0.011555846780538559,
0.042741306126117706,
-0.023908648639917374,
0.018661007285118103,
0.028714898973703384,
0.030603069812059402,
-0.03195176273584366,
-0.00505759846419096,
-0.01725100912153721,
-0.01769240014255047,
-0.032908108085393906,
0.01273901853710413,
-0.005305880680680275,
0.009520546533167362,
-0.04391834884881973,
-0.000172418134752661,
-0.035458363592624664,
0.007086768746376038,
0.044850170612335205,
0.0031357111874967813,
-0.02249865047633648,
0.03231958672404289,
-0.04021557420492172,
0.03222149983048439,
-0.004272904712706804,
-0.05331015586853027,
-0.05149554833769798,
-0.043575044721364975,
-0.003466753987595439,
-0.009489893913269043,
0.017054835334420204,
-0.010991848073899746,
0.017949877306818962,
0.02322204038500786,
-0.0234795194119215,
0.032246023416519165,
-0.019151439890265465,
-0.06297170370817184,
0.013768929056823254,
-0.013008756563067436,
0.01895526610314846,
0.011647802777588367,
0.05056372657418251,
-0.025110211223363876,
0.015044056810438633,
0.010758891701698303,
0.01707935705780983,
-0.03879331424832344,
-0.032908108085393906,
0.024300996214151382,
-0.033128805458545685,
-0.00758333271369338,
-0.029744811356067657,
-0.000014463966181210708,
0.0018329963786527514,
-0.004055274650454521,
-0.042520612478256226,
-0.004358730278909206,
-0.012775801122188568,
-0.010930543765425682,
-0.02095378376543522,
-0.03906305134296417,
0.011218673549592495,
-0.033079762011766434,
-0.0006927377544343472,
-0.010225544683635235,
-0.03388897702097893,
-0.00013295354438014328,
0.04519347473978996,
-0.013168147765100002,
-0.018501615151762962,
-0.0004264475137460977,
0.04122096300125122,
0.037223927676677704,
0.0174103993922472,
0.025772295892238617,
0.030406896024942398,
-0.020904740318655968,
-0.003022298449650407,
0.003711970988661051,
-0.05497762933373451,
0.037052273750305176,
-0.016233358532190323,
-0.012083062902092934,
-0.01370762474834919,
0.013597276993095875,
-0.023307867348194122,
-0.02425195276737213,
-0.04271678626537323,
0.007399420253932476,
-0.037493664771318436,
-0.016270142048597336,
-0.009845458902418613,
0.02316073700785637,
-0.0030973961111158133,
0.062039878219366074,
-0.025453515350818634,
0.007485245820134878,
-0.029475072398781776,
-0.01161102019250393,
-0.05056372657418251,
0.016662489622831345,
0.03359471634030342,
-0.036610882729291916,
0.04055887460708618,
-0.027047425508499146,
0.07238803058862686,
0.015436404384672642,
0.0017885507550090551,
0.026213686913251877,
0.013867015950381756,
0.015007274225354195,
-0.00619172677397728,
0.0020858761854469776,
0.007994071580469608,
0.021812044084072113,
-0.033790890127420425,
0.023332389071583748,
0.007105160038918257,
-0.011279977858066559,
-0.015313795767724514,
0.03891592472791672,
0.005704358220100403,
0.004754142835736275,
0.02249865047633648,
-0.01647857576608658,
0.04742494970560074,
0.030652113258838654,
0.028592290356755257,
-0.018109267577528954,
0.02736620604991913,
-0.014737536199390888,
-0.038376446813344955,
-0.003249123925343156,
-0.0190165713429451,
0.022351520135998726,
0.025159254670143127,
-0.017214227467775345,
-0.007742723915725946,
0.0404362678527832,
0.01862422376871109,
0.03952896595001221,
-0.010679196566343307,
0.05483049899339676,
0.005823901388794184,
0.006725073792040348,
-0.003206211142241955,
0.0011279977625235915,
-0.002557918895035982,
0.04129452630877495,
0.005045337602496147,
-0.06061761826276779,
0.028150901198387146,
-0.018599702045321465,
-0.011684585362672806,
0.016110749915242195,
-0.02552708052098751,
-0.01097345631569624,
0.04408999904990196,
0.0338154099881649,
0.08327566087245941,
0.07081864029169083,
-0.004959512036293745,
-0.0018728440627455711,
-0.01251219306141138,
-0.025576123967766762,
-0.01851387694478035,
0.04708164557814598,
-0.006072183605283499,
0.02945055067539215,
0.004637664649635553,
0.028837507590651512,
0.02007100358605385,
0.037272971123456955,
0.021787522360682487,
0.004564099479466677,
-0.022559955716133118,
0.03204984962940216,
-0.03327593579888344,
-0.011531325057148933,
0.05502667278051376,
-0.007865332067012787,
0.038940444588661194,
-0.01193593256175518,
-0.06714038550853729,
0.01097345631569624,
-0.024681081995368004,
-0.013781189918518066,
0.007509767543524504,
0.052280243486166,
0.014332927763462067,
0.004033817909657955,
-0.06566908955574036,
-0.0024153864942491055,
0.020536916330456734,
-0.00043564316001720726,
-0.0061733354814350605,
-0.006308204960078001,
0.026556991040706635,
-0.004272904712706804,
-0.025821339339017868,
-0.051201291382312775,
0.049264077097177505,
0.016588924452662468,
0.009404067881405354,
-0.0022422021720558405,
-0.03984774649143219,
-0.005462206434458494,
0.015301534906029701,
0.002700451062992215,
-0.019090136513113976,
0.00746072456240654,
-0.028322553262114525,
-0.0392347052693367,
0.010017110966145992,
0.022829694673419,
-0.01607396826148033,
-0.046836428344249725,
0.006645378191024065,
0.02773403190076351,
-0.07341793924570084,
0.01384249422699213,
0.02221665158867836,
0.01379345078021288,
0.007883723825216293,
0.027170032262802124,
0.006939638406038284,
0.00478172954171896,
0.07150524854660034,
0.04259417578577995,
-0.03511505946516991,
0.03629210218787193,
-0.016490837559103966,
-0.029646724462509155,
-0.05019589886069298,
-0.010464631021022797,
0.057773102074861526,
-0.036439232528209686,
0.03276097774505615,
0.007816288620233536,
-0.01337658241391182,
0.014492318965494633,
-0.003006972372531891,
-0.0038407098036259413,
0.009722850285470486,
-0.05144650489091873,
-0.014087711460888386,
0.04850390553474426,
0.055517107248306274,
0.030161678791046143,
-0.006835421081632376,
-0.032417673617601395,
-0.01696901023387909,
-0.015154404565691948,
-0.026777686551213264,
0.023405954241752625,
-0.011782672256231308,
-0.018415790051221848,
-0.0009417861583642662,
0.009869980625808239,
-0.005109707359224558,
-0.008496765978634357,
0.008049244992434978,
-0.013021017424762249,
0.0651296079158783,
0.010403327643871307,
0.02271934598684311,
0.05654701963067055,
0.018943006172776222,
0.03737105801701546,
0.05394772067666054,
-0.00025575357722118497,
0.0479644276201725,
-0.016380488872528076,
-0.02117447927594185,
0.0032031459268182516,
-0.020867958664894104,
-0.042912960052490234,
-0.028641333803534508,
-0.03099541738629341,
0.00823315791785717,
-0.011365803889930248,
-0.003121917834505439,
-0.024889515712857246,
-0.018195094540715218,
-0.013217191211879253,
0.001379345078021288,
0.01730005256831646,
-0.023663431406021118,
-0.01945796236395836,
-0.031363241374492645,
-0.011598759330809116,
-0.04320721700787544,
0.019102396443486214,
-0.011457759886980057,
-0.017949877306818962,
0.002547190524637699,
-0.015460926108062267,
-0.024386821314692497,
-0.010666935704648495,
0.013266234658658504,
-0.021628130227327347,
-0.014271623454988003,
-0.010630153119564056,
-0.037886012345552444,
0.03276097774505615,
-0.010170371271669865,
0.0005800912622362375,
0.013658581301569939,
-0.02199595607817173,
-0.03607140854001045,
0.024509429931640625,
-0.02653246931731701,
0.02807733602821827,
-0.055124759674072266,
0.02525734156370163,
-0.009900632314383984,
0.00618866179138422,
0.00023199818679131567,
-0.01989935152232647,
-0.011482281610369682,
-0.01597588136792183,
-0.028837507590651512,
-0.03349662944674492,
0.043526001274585724,
-0.002858309540897608,
-0.03239315375685692,
-0.005333467852324247,
-0.0070070731453597546,
0.027930205687880516,
-0.008251548744738102,
-0.032859064638614655,
0.03332497924566269,
-0.028445161879062653,
-0.0038161880802363157,
0.01119415182620287,
-0.019041093066334724,
0.03668444976210594,
-0.004300491418689489,
-0.030529504641890526,
-0.009802545420825481,
-0.005109707359224558,
0.04735138267278671,
-0.025110211223363876,
-0.05169172212481499,
-0.012309888377785683,
0.02016909047961235,
-0.038499053567647934,
0.019482482224702835,
-0.046787384897470474,
-0.008061505854129791,
-0.018440311774611473,
0.03249124065041542,
0.009195634163916111,
0.015203448012471199,
0.020267177373170853,
0.00823928788304329,
-0.05129937827587128,
-0.006663769483566284,
-0.0030008419416844845,
0.017618834972381592,
-0.04421260952949524,
-0.011843976564705372,
0.00780402822420001,
-0.0007226235466077924,
-0.001344861462712288,
-0.012365062721073627,
-0.023724734783172607,
-0.0013801114400848746,
-0.021542305126786232,
0.010838586837053299,
-0.023025866597890854,
-0.014516840688884258,
0.025576123967766762,
-0.011837845668196678,
-0.021346131339669228,
-0.015902316197752953,
0.02891107276082039,
0.018391268327832222,
-0.005502054467797279,
-0.015436404384672642,
-0.0036138840951025486,
-0.044678520411252975,
-0.03310428187251091,
-0.0017180509166792035,
0.001474366639740765,
0.0016751380171626806,
0.004058339633047581,
0.006461465265601873,
-0.015375100076198578,
-0.0023448867723345757,
-0.025330906733870506,
-0.01019489299505949,
-0.021897869184613228,
-0.039651572704315186,
-0.01657666265964508,
0.025551602244377136,
0.011899149976670742,
-0.02437455952167511,
0.01906561478972435,
-0.0040920572355389595,
0.013744407333433628,
0.013180408626794815,
0.03433036804199219,
0.047498513013124466,
0.022694824263453484,
-0.049043379724025726,
0.009091416373848915,
-0.004585556220263243,
-0.03710131719708443,
-0.022841954603791237,
0.008122810162603855,
-0.011114456690847874,
-0.011801064014434814,
-0.017704660072922707,
0.003601623233407736,
-0.0191146582365036,
-0.0016214967472478747,
-0.011494542472064495,
-0.009177242405712605,
0.015277013182640076,
0.03945539891719818,
0.08155914396047592,
-0.014369710348546505,
0.01329075638204813,
-0.018280919641256332,
-0.016588924452662468,
-0.015669360756874084,
-0.006158009637147188,
0.021640392020344734,
-0.004895142279565334,
0.00012394948862493038,
-0.005437684711068869,
0.056399889290332794,
0.016564402729272842,
-0.04779277369379997,
-0.05620371550321579,
-0.030848287045955658,
-0.0030820700339972973,
-0.010562717914581299,
-0.04482565075159073,
-0.04953381419181824,
0.011586498469114304,
0.015424143522977829,
0.016110749915242195,
-0.03631662204861641,
-0.026924816891551018,
0.00820250529795885,
0.0028675051871687174,
0.032246023416519165,
-0.010856978595256805,
0.0034146453253924847,
-0.02790568396449089,
-0.021591348573565483,
-0.005502054467797279,
-0.021407436579465866,
-0.0037947315722703934,
-0.0030560155864804983,
-0.001673605409450829,
-0.0076814196072518826,
-0.009355025365948677,
-0.02790568396449089,
-0.05492858588695526,
0.03974965959787369,
0.0008329711854457855,
0.032466717064380646,
-0.02900915965437889,
-0.00018515791452955455,
-0.018047964200377464,
-0.011427108198404312,
-0.025821339339017868,
0.02918081171810627,
0.033521149307489395,
-0.0026207556948065758,
0.007987940683960915,
-0.02913176827132702,
-0.02194691263139248,
-0.02023039385676384,
0.021199000999331474,
-0.003469819203019142,
-0.0018238007323816419,
0.03138776496052742,
0.04759659990668297,
0.012285366654396057,
0.03737105801701546,
-0.03867070749402046,
-0.01818283274769783,
0.03045593947172165,
0.024117082357406616,
-0.02194691263139248,
0.05747884139418602,
-0.013891537673771381,
0.0087051996961236,
-0.009630894288420677,
-0.007160333450883627,
-0.010912152007222176,
-0.02005874365568161,
-0.02736620604991913,
0.012775801122188568,
-0.03979870304465294,
-0.02653246931731701,
-0.027439771220088005,
-0.01608622819185257,
-0.0023341584019362926,
-0.007785636931657791,
-0.02663055621087551,
0.011825584806501865,
-0.03403610736131668,
0.036831580102443695,
0.010660804808139801,
0.025502558797597885,
0.0007176426006481051,
-0.018611963838338852,
0.01397736370563507,
0.009416328743100166,
-0.00709902960807085,
-0.02702290378510952,
-0.01157423760741949,
-0.024693341925740242,
0.015436404384672642,
0.01110832579433918,
0.024460386484861374,
0.0015939099248498678,
-0.05831257998943329,
-0.007589463144540787,
0.030799243599176407,
0.008576461113989353,
0.013339799828827381,
0.0053518591448664665,
0.029867419973015785,
-0.003134178463369608,
-0.013253973796963692,
0.0013387310318648815,
-0.050710856914520264,
-0.01790083386003971,
0.025355428457260132,
-0.014038668014109135,
-0.008827808313071728,
0.007742723915725946,
-0.014639449305832386,
0.010685326531529427,
0.01662570610642433,
-0.00884006917476654,
-0.012469279579818249,
0.0021441152784973383,
-0.009042372927069664,
0.01406318973749876,
0.006485986988991499,
0.005741140805184841,
-0.02587038278579712,
0.0380331426858902,
-0.026900295168161392,
0.004147231113165617,
-0.01652761921286583,
-0.0012145900400355458,
-0.01591457799077034,
0.00429742643609643,
0.013278495520353317,
0.01917596161365509,
0.02150552347302437,
-0.07052437961101532,
-0.04752303659915924,
-0.005137294065207243,
-0.03972513973712921,
-0.019531525671482086,
0.04256965592503548,
-0.01889396272599697,
-0.017986660823225975,
0.002236071741208434,
-0.015657098963856697,
-0.012665453366935253,
-0.041637830436229706,
0.03504149615764618,
-0.0021195935551077127,
0.00004169166277279146,
-0.007000942714512348,
-0.026998382061719894,
-0.04646860435605049,
0.011776542291045189,
0.03857262060046196,
-0.019261788576841354,
0.0021625065710395575,
-0.01397736370563507,
0.028028292581439018,
0.018170572817325592,
0.03984774649143219,
-0.002167104510590434,
-0.01161102019250393,
-0.021579086780548096,
0.00625609653070569,
0.03871975094079971,
0.014283884316682816,
-0.025330906733870506,
0.000892742769792676,
-0.02891107276082039,
-0.026115600019693375,
0.029720289632678032,
-0.02300134487450123,
0.006344987545162439,
0.008692938834428787,
-0.0032154065556824207,
-0.010807935148477554,
0.021125435829162598,
0.009667676873505116,
0.017422661185264587,
0.0033962540328502655,
-0.030382374301552773,
0.001076655462384224,
0.014492318965494633,
-0.01824413798749447,
0.0338154099881649,
-0.03820479288697243,
-0.01961735263466835,
0.01818283274769783,
-0.002715777140110731,
0.019372135400772095,
0.018930744379758835,
0.011917541734874249,
-0.0027203750796616077,
0.0032889717258512974,
-0.03543384373188019,
0.05316302552819252,
0.0141980592161417,
-0.04100026562809944,
-0.0040920572355389595,
-0.023969952017068863,
-0.052280243486166,
0.027219075709581375,
-0.01928631030023098,
0.002436843002215028,
0.006013944745063782,
-0.007411681115627289,
-0.046223387122154236,
0.05100511759519577,
-0.025772295892238617,
0.014749797061085701,
0.014860144816339016,
-0.018280919641256332,
0.014283884316682816,
0.012162758968770504,
-0.025674210861325264,
-0.03200080618262291,
0.0076017240062355995,
0.02702290378510952,
-0.014847883954644203,
0.009079155512154102,
0.04100026562809944,
-0.02785664051771164,
0.015669360756874084,
0.001328769139945507,
0.015007274225354195,
0.00464379508048296,
0.0018636485328897834,
0.015277013182640076,
-0.011568107642233372,
-0.01818283274769783,
-0.03800861909985542,
0.010666935704648495,
0.017594313248991966,
-0.009735111147165298,
0.03587523475289345,
-0.017606573179364204,
0.011512933298945427,
-0.05801831930875778,
-0.029695767909288406,
-0.012168888933956623,
0.06615952402353287,
-0.01448005810379982,
0.016429532319307327,
-0.04166235402226448,
0.039823226630687714,
0.014332927763462067,
0.02111317589879036,
0.002777081448584795,
0.007920506410300732,
0.030701156705617905,
0.03254028409719467,
-0.0007843109196983278,
0.03344758599996567,
-0.027537858113646507,
0.05267259106040001,
0.029082724824547768,
-0.035286713391542435,
-0.07390837371349335,
-0.010617892257869244,
0.004061405081301928,
0.013781189918518066,
0.01516666542738676,
0.0075220284052193165,
0.004064470063894987,
-0.0032154065556824207,
-0.0017487030709162354,
-0.0003015401598531753,
-0.026728643104434013,
-0.024693341925740242,
0.032687414437532425,
0.016208836808800697,
0.014136754907667637,
-0.028052814304828644,
0.023700213059782982,
-0.002669799141585827,
0.015816491097211838,
0.03045593947172165,
-0.0078775929287076,
0.0011471553007140756,
-0.02542899362742901,
-0.03410967066884041,
0.008974938653409481,
-0.02552708052098751,
-0.0012735952623188496,
-0.03469819203019142,
0.041368093341588974,
0.02248639054596424,
0.04798894748091698,
-0.0157551858574152,
0.0337173230946064,
0.018329963088035583,
-0.04227539524435997,
-0.017594313248991966,
0.012150498107075691,
0.005299750249832869,
0.06998490542173386,
-0.04548773542046547,
0.01747170463204384,
0.020867958664894104,
-0.001642953255213797,
-0.013646320439875126,
-0.006038466468453407,
0.02989193983376026,
0.03742010146379471,
0.019372135400772095,
-0.0676308199763298,
0.05664510652422905,
-0.007577202282845974,
-0.038597140461206436,
0.011733628809452057,
0.04332982748746872,
0.01157423760741949,
0.03249124065041542,
-0.018084745854139328,
-0.03540932014584541,
0.0037947315722703934,
0.0005237679579295218,
0.022253433242440224,
0.05733171105384827,
-0.0019356809789314866,
0.02736620604991913,
-0.056399889290332794,
0.007381028961390257,
0.00895654782652855,
-0.026213686913251877,
-0.024300996214151382,
0.020144568756222725,
0.05041659623384476,
0.022363781929016113,
-0.024300996214151382,
-0.008257679641246796,
0.028886551037430763,
-0.037444621324539185,
0.006547291297465563,
-0.01922500506043434,
0.012407975271344185,
0.0305049829185009,
-0.014663971029222012,
-0.025772295892238617,
0.01802344247698784,
0.024300996214151382,
-0.005931183695793152,
0.006118161603808403,
0.030431417748332024,
0.0027096467092633247,
0.017925355583429337,
-0.046345993876457214,
0.06154944375157356,
0.017815008759498596,
-0.041417136788368225,
-0.011059282347559929,
-0.004242252558469772,
-0.031068982556462288,
-0.0217752605676651,
-0.03077472187578678,
-0.027390727773308754,
-0.012138237245380878,
-0.010342023335397243,
-0.007834680378437042,
0.000025335886675748043,
0.05183885246515274,
0.011138977482914925,
-0.005581749603152275,
0.024791428819298744,
-0.03609592840075493,
0.02084343694150448,
0.016650227829813957,
0.005253772251307964,
-0.018440311774611473,
-0.00046437952551059425,
-0.015509969554841518,
-0.02050013281404972,
0.018648745492100716,
-0.021199000999331474,
0.054585281759500504,
-0.020598219707608223,
0.009649285115301609,
-0.008361896499991417,
-0.009673806838691235,
0.011175760067999363,
0.06640473753213882,
-0.019028831273317337,
-0.007595593575388193,
0.026655077934265137,
0.01146389078348875,
0.006841551512479782,
0.029058203101158142,
0.007828549481928349,
0.04320721700787544,
-0.001245242077857256,
0.014970491640269756,
0.028494205325841904,
0.022020477801561356,
0.005137294065207243,
-0.013192669488489628,
0.030259765684604645,
0.008386418223381042,
-0.01097345631569624,
0.014467797242105007,
-0.019911613315343857,
0.0158532727509737,
-0.0019172896863892674,
0.0014935241779312491,
0.032908108085393906,
0.006013944745063782,
0.01161102019250393,
0.02166491374373436,
0.016147533431649208,
-0.020095525309443474,
0.012273105792701244,
0.029744811356067657,
0.006102835759520531,
-0.0030314940959215164,
0.018415790051221848,
-0.047228775918483734,
-0.012886147946119308,
-0.03168202564120293,
-0.001137959654442966,
-0.005403967574238777,
0.011843976564705372,
-0.018697788938879967,
-0.002774016233161092,
-0.011120586656033993,
-0.0020736155565828085,
0.0006157243042252958,
0.015951359644532204,
-0.013719885610044003,
-0.04001940041780472,
-0.007074507884681225,
-0.026924816891551018,
0.0033656021114438772,
0.0062254443764686584,
0.026507947593927383,
0.026238208636641502,
0.03155941516160965,
0.03827835991978645,
-0.014958230778574944,
-0.038768794387578964,
0.008049244992434978,
-0.027341684326529503,
-0.02530638501048088,
-0.004821577575057745,
0.03778792545199394,
-0.023442735895514488,
-0.027979249134659767,
0.013744407333433628,
-0.007853071205317974,
-0.006614726036787033,
0.019274048507213593,
0.015485447831451893,
-0.01439423207193613,
0.020696306601166725,
-0.014050928875803947,
0.009722850285470486,
-0.018428049981594086,
-0.028984637930989265,
-0.009079155512154102,
-0.018636485561728477,
-0.03254028409719467,
0.022363781929016113,
-0.005216989666223526,
0.018697788938879967,
-0.0014536764938384295,
-0.008686808869242668,
0.03925922513008118,
-0.01047076191753149,
0.021468739956617355,
0.022351520135998726,
0.0016475510783493519,
0.011568107642233372,
0.007595593575388193,
-0.02569873258471489,
-0.0004494366003200412,
0.008490635082125664,
0.012150498107075691,
0.02056143805384636,
0.016944488510489464,
0.00703159486874938,
0.029033681377768517,
-0.0019295505480840802,
0.007221637759357691,
-0.014663971029222012,
-0.03178011253476143,
0.019372135400772095,
0.0457574762403965,
-0.02183656580746174,
-0.036782536655664444,
0.03665992617607117,
-0.005992488004267216,
0.006633117329329252,
-0.0012414106167852879,
0.020635003224015236,
0.003806992433965206,
0.029254376888275146,
-0.045732952654361725,
0.01983804814517498,
0.03447749838232994,
-0.001387008116580546,
0.0067005520686507225,
0.014320666901767254,
-0.0012046280317008495,
-0.03403610736131668,
0.0011709107784554362,
-0.0029288094956427813,
0.03783696889877319,
-0.004266774281859398,
0.006749595515429974,
0.010863108560442924,
-0.023467257618904114,
0.021591348573565483,
0.024619776755571365,
0.028592290356755257,
0.0005003957194276154,
-0.0008184114121831954,
0.013474669307470322,
0.003091265680268407,
-0.004233056679368019,
-0.02155456505715847,
-0.0013693831861019135,
-0.03565453737974167,
-0.0045457081869244576,
-0.016503097489476204,
0.007938897237181664,
-0.004668316803872585,
-0.001387008116580546,
-0.019715439528226852,
-0.011825584806501865,
0.0033839934039860964,
-0.021640392020344734,
0.00491966400295496,
-0.02298908494412899,
-0.00641242228448391,
-0.015595795586705208,
0.005336532834917307,
-0.025061167776584625,
0.012009497731924057,
0.019053352996706963,
0.016049446538090706,
0.030480461195111275,
0.01779048703610897,
-0.0032429934944957495,
0.0005260668694972992,
0.0044292304664850235,
-0.012555105611681938,
-0.02989193983376026,
0.0018943005707114935,
-0.04862651228904724,
-0.006492117419838905,
-0.03580166772007942,
0.004637664649635553,
-0.018195094540715218,
0.030137157067656517,
-0.012591888196766376,
-0.0012283833930268884,
0.01707935705780983,
0.0119665851816535,
-0.011580368503928185,
0.015044056810438633,
0.008668418042361736,
0.0015831816708669066,
0.03469819203019142,
-0.0055878800339996815,
-0.029426028952002525,
-0.01342562586069107,
-0.026924816891551018,
0.007135811727494001,
0.007062247022986412,
-0.01961735263466835,
-0.0294015072286129,
-0.005584815051406622,
0.008502895943820477,
0.007902114652097225,
-0.02062274143099785,
0.024178387597203255,
-0.011402586475014687,
-0.030210722237825394,
0.052084069699048996,
0.025232819840312004,
0.008797156624495983,
-0.01725100912153721,
-0.007442333269864321,
-0.013830233365297318,
0.0202181339263916,
0.02746429294347763,
0.025576123967766762,
0.013903798535466194,
-0.020414307713508606,
0.001490458962507546,
-0.0011065412545576692,
0.04759659990668297,
-0.030750200152397156,
-0.03680705651640892,
0.012395714409649372,
0.02547803707420826,
-0.028494205325841904,
-0.00892589520663023,
0.005195533391088247,
0.014860144816339016,
-0.0028858964797109365,
-0.00016101938672363758,
0.011819454841315746,
-0.006504378281533718,
-0.04212826490402222,
-0.023798299953341484,
-0.01635596714913845,
0.030823765322566032,
0.014014146290719509,
0.004168687388300896,
0.0338154099881649,
-0.018219616264104843,
0.015375100076198578,
0.011978846043348312,
0.003601623233407736,
-0.025551602244377136,
-0.023504041135311127,
-0.011598759330809116,
0.005063728895038366,
0.0022820497397333384,
0.012849366292357445,
0.013008756563067436,
-0.0457574762403965,
-0.028445161879062653,
0.026458904147148132,
0.017864052206277847,
0.008386418223381042,
-0.03310428187251091,
-0.013499191030859947,
-0.039038531482219696,
-0.009109808132052422,
-0.005918922834098339,
-0.005802445113658905,
0.009397937916219234,
-0.011145108379423618,
0.008300592191517353,
0.0008536613313481212,
0.009814806282520294,
0.014909188263118267,
-0.01483562309294939,
-0.0018988983938470483,
0.01492144912481308,
-0.029303420335054398,
-0.015497708693146706,
0.0017563661094754934,
0.019151439890265465,
-0.009207895025610924,
-0.01069758739322424,
0.003252189140766859,
0.024889515712857246,
0.026287252083420753,
-0.05625275894999504,
-0.0008222429314628243,
0.018170572817325592,
0.024460386484861374,
-0.016993531957268715,
0.004784794989973307,
-0.0020475611090660095,
0.015657098963856697,
-0.03862166404724121,
0.010624022223055363,
-0.017373617738485336,
-0.0014789644628763199,
0.031240634620189667,
-0.019936135038733482,
0.003497406141832471,
0.02552708052098751,
0.011512933298945427,
-0.00548366317525506,
-0.022290216758847237,
-0.007282942067831755,
0.02979385480284691,
-0.025232819840312004,
-0.004134970251470804,
-0.014467797242105007,
0.020647263154387474,
0.009686067700386047,
-0.047498513013124466,
0.034722715616226196,
0.014222580939531326,
-0.008968808688223362,
0.01564483903348446,
0.008944286964833736,
-0.03155941516160965,
-0.00792663637548685,
0.026336295530200005,
-0.0068170297890901566,
-0.0006800937699154019,
-0.008932026103138924,
0.01824413798749447,
-0.01315588690340519,
-0.00046054800623096526,
0.01768013834953308,
-0.01193593256175518,
-0.02486499398946762,
0.012095323763787746,
0.008809417486190796,
0.006161074619740248,
0.0029349399264901876,
0.04276582971215248,
-0.00119543238542974,
-0.012199540622532368,
-0.00026629024068824947,
-0.008306723088026047,
0.01802344247698784,
-0.003482080064713955,
-0.008502895943820477,
-0.006676030345261097,
-0.007313594222068787,
0.007699810899794102,
-0.009134329855442047,
0.010495283640921116,
0.02259673736989498,
-0.00043487685616128147,
-0.02790568396449089,
-0.00730746379122138,
-0.0361204519867897,
0.03200080618262291,
-0.029327942058444023,
0.0328100211918354,
-0.007258420344442129,
-0.0174103993922472,
-0.05934249237179756,
0.014247102662920952,
0.01064241398125887,
0.008600982837378979,
-0.028592290356755257,
0.01834222488105297,
0.015951359644532204,
-0.005259902682155371,
0.0032031459268182516,
0.0206717848777771,
-0.004272904712706804,
0.02083117701113224,
-0.01651535928249359,
-0.043182697147130966,
-0.03293263167142868,
0.00878489576280117,
0.008846200071275234,
-0.024227431043982506,
-0.0031081242486834526,
-0.00978415459394455,
0.03231958672404289,
-0.016772836446762085,
-0.024190647527575493,
-0.03195176273584366,
-0.04563486576080322,
0.012144367210566998,
-0.027317162603139877,
-0.009318242780864239,
0.00618866179138422,
0.01293519139289856,
-0.026336295530200005,
0.018084745854139328,
-0.005572554189711809,
0.018857179209589958,
0.042299915105104446,
0.027758553624153137,
-0.005480597727000713,
0.009624763391911983,
0.027537858113646507,
0.0179130956530571,
-0.004898207727819681,
-0.016368228942155838,
0.010311370715498924,
-0.026066556572914124,
0.0025226688012480736,
0.03553193062543869,
0.005085185635834932,
-0.0164050105959177,
0.005872944835573435,
-0.01091828290373087,
-0.018268659710884094,
0.0012253181776031852,
-0.05041659623384476,
0.020156830549240112,
-0.020978305488824844,
0.022008217871189117,
0.018587442114949226,
0.014026407152414322,
-0.033570192754268646,
0.016772836446762085,
-0.005266033113002777,
-0.006547291297465563,
-0.009079155512154102,
-0.0018559854943305254,
-0.02182430401444435,
0.016331445425748825,
0.013401104137301445,
0.028935594484210014,
0.005560293328016996,
0.014369710348546505,
0.01237732358276844,
0.026704121381044388,
-0.023908648639917374,
0.0013502255314961076,
-0.013744407333433628,
-0.02653246931731701,
-0.01845257170498371,
0.011157369241118431,
0.020353002473711967,
0.006951899267733097,
-0.020708568394184113,
0.004603947512805462,
-0.010942804627120495,
-0.003132645972073078,
-0.03128967806696892,
0.0010168838780373335,
-0.023749256506562233,
-0.01978900469839573,
0.09779249876737595,
-0.022535433992743492,
-0.0009433187660761178,
-0.010660804808139801,
0.025159254670143127,
-0.021149957552552223,
0.012947452254593372,
0.01818283274769783,
0.014467797242105007,
-0.022363781929016113,
0.017140662297606468,
0.022523172199726105,
0.00196786574088037,
0.01668700948357582,
0.032196979969739914,
-0.017986660823225975,
0.010090675204992294,
0.007552680559456348,
-0.0061947922222316265,
-0.027390727773308754,
-0.03820479288697243,
-0.01829318143427372,
-0.0026176904793828726,
0.01812152937054634,
-0.017005791887640953,
-0.005508184898644686,
0.009661545976996422,
-0.012052411213517189,
-0.01989935152232647,
0.018636485561728477,
-0.004600882064551115,
0.016380488872528076,
0.0051832725293934345,
-0.02437455952167511,
-0.013781189918518066,
-0.027219075709581375,
-0.035728104412555695,
-0.027292640879750252,
0.0014958231477066875,
-0.021137697622179985,
0.02596846967935562,
0.003436101833358407,
-0.028273509815335274,
-0.007221637759357691,
0.009869980625808239,
-0.01818283274769783,
-0.024448124691843987,
0.028935594484210014,
0.01989935152232647,
-0.02227795496582985,
0.009961936622858047,
-0.009649285115301609,
0.011304499581456184,
-0.020512394607067108,
-0.038548097014427185,
-0.0026376142632216215,
0.007368768099695444,
0.02746429294347763,
0.005379445850849152,
-0.023835083469748497,
-0.016208836808800697,
0.012076932936906815,
0.02426421269774437,
0.016270142048597336,
0.014541362412273884
] | 2025-01-22 | 22 | 39839908 | [
"CAR LV",
"LV potency",
"LV MOA",
"LV quantification",
"T cells",
"activated T cells",
"patient T cells",
"LV",
"Jurkat reporter cells",
"Jurkat T cells",
"target cells",
"simple bioassays",
"quality control settings",
"potency testing",
"CAR",
"functional titer",
"potency",
"CAR expression",
"cancer immunotherapy",
"CAR)-T-cell therapy",
"drug development",
"Chimeric antigen receptor",
"other approaches",
"MOA",
"a bioluminescent reporter bioassay",
"the LV",
"Common methods",
"CAR-T manufacturing",
"Jurkat",
"use"
] | [
"CAR-T",
"bioassay",
"lentivirus",
"potency assay"
] | 0 | 10.1093/abt/tbae032
10.1016/j.ebiom.2020.102931
10.1038/nbt0102-70
10.4049/jimmunol.172.1.104
10.3390/biom12091303
10.3389/fmed.2023.1190016
10.1016/j.jcyt.2022.09.004
10.1186/1472-6750-6-34
10.1016/j.omtm.2024.101186
10.1038/nri1330
10.1016/j.jim.2016.01.007
10.1002/cti2.1216
10.1093/protein/gzz027
10.1016/j.omtm.2020.01.012
10.1016/j.jim.2009.05.001
10.1002/ijc.10317
10.3389/fimmu.2023.1233113
10.1097/CJI.0b013e3181ac6138
10.1016/S0092-8674(02)00699-2
10.3390/cancers15030663
10.1016/j.cell.2016.01.011
10.1016/j.ccell.2022.11.006
10.1016/j.ymthe.2023.09.021
10.1097/CJI.0000000000000453
10.3390/ijms23094538 | [
"Gilden",
"Stecha",
"Hartnett",
"Cong"
] | [
"Research and Development, Promega Corp., Madison, WI 53711, United States.",
"Research and Development, Promega Corp., Madison, WI 53711, United States.",
"Research and Development, Promega Corp., Madison, WI 53711, United States.",
"Research and Development, Promega Corp., Madison, WI 53711, United States."
] | [
"39839908",
"32739874",
"11753365",
"14688315",
"20683006",
"37215709",
"36253252",
"16836756",
"38282894",
"15057788",
"26780292",
"31504896",
"32083149",
"19427315",
"11948485",
"37559730",
"19561539",
"11983154",
"26830879",
"36513049",
"37803832",
"36809225"
] | [] | 8.165737 | 4.711771 |
39837618 | 8 | Art of TIL immunotherapy: SITC's perspective on demystifying a complex treatment. | In a first for solid cancers, cellular immunotherapy has entered standard of care in the treatment of patients with metastatic melanoma. The infusion of autologous tumor-infiltrating T lymphocytes (TIL) is capable of mediating durable tumor regression and is now Food and Drug Administration-approved for patients with disease refractory to immune checkpoint inhibitors. Since the advent of chimeric antigen receptor (CAR) T cells for patients with hematological malignancies, a growing network of centers capable of delivering effector T cell products to patients has developed. Administration of TIL can be layered onto that institutional framework, but there are many complex and unique aspects to TIL immunotherapy. The highly multidisciplinary clinical expertise and coordination required to successfully and safely deliver TIL to patients began within the National Cancer Institute Surgery Branch and have been subsequently adopted worldwide. The general steps, most of which require hospital inpatient resources, include a surgical procedure to harvest sufficient tumor for TIL manufacturing, admission for non-myeloablative lymphodepleting chemotherapy followed by TIL, and intravenous interleukin-2 (IL-2, aldesleukin). Here, we provide the principles, practice, and required resources underlying the efficient and safe delivery of TIL immunotherapy derived from the clinical expertise of high-volume centers around the world. This article enhances published clinical practice guidelines by providing underlying clinical rationale and data-driven examples to demystify TIL immunotherapy in order to facilitate uptake and improve patient access to this promising treatment modality in clinical and research settings. | [
-0.029780112206935883,
0.007054430432617664,
0.02348320372402668,
0.03451462835073471,
-0.008457031100988388,
-0.04793698340654373,
-0.0031869218219071627,
0.024666834622621536,
-0.028217721730470657,
0.03053763508796692,
0.03281020373106003,
-0.020701676607131958,
-0.03650312498211861,
-0.013670917600393295,
0.03991197794675827,
-0.0296144038438797,
0.06235358864068985,
0.0028806577902287245,
0.012854213826358318,
0.04107193648815155,
0.03127148374915123,
0.013812953606247902,
-0.029993165284395218,
0.00861682090908289,
-0.027010420337319374,
-0.02954338677227497,
0.0037521047051995993,
-0.004400142002850771,
-0.03262082114815712,
-0.020831875503063202,
0.005015628878027201,
-0.02221672050654888,
-0.04500158503651619,
-0.02580311708152294,
0.010054930113255978,
0.021968159824609756,
0.05387880280613899,
0.03162657469511032,
-0.011640993878245354,
-0.005441735498607159,
-0.0009291489841416478,
0.011078770272433758,
0.01577777788043022,
0.09606335312128067,
-0.04751087725162506,
-0.00979453232139349,
0.03392281383275986,
-0.05866066738963127,
0.017411187291145325,
-0.030490290373563766,
-0.008480703458189964,
0.004536258988082409,
-0.034609317779541016,
0.030940068885684013,
-0.0642947405576706,
0.060412436723709106,
-0.046800702810287476,
0.023660749197006226,
-0.004645744804292917,
0.0005600046133622527,
-0.006231808103621006,
0.005125114694237709,
0.013517046347260475,
-0.03212369978427887,
-0.04424406215548515,
-0.007918479852378368,
-0.060175713151693344,
-0.01204934623092413,
-0.0005440996028482914,
0.019411519169807434,
0.017174459993839264,
-0.012368925847113132,
-0.030727015808224678,
-0.007740935310721397,
-0.005388472229242325,
0.028904225677251816,
-0.01981395296752453,
0.036952905356884,
0.008297241292893887,
-0.048528797924518585,
0.04381795600056648,
-0.020843710750341415,
0.021222472190856934,
-0.03868100419640541,
-0.020464949309825897,
0.01994415372610092,
0.005503876134753227,
0.0027637742459774017,
-0.02703409269452095,
-0.03787613660097122,
-0.02734183520078659,
0.030608652159571648,
-0.048528797924518585,
0.056672170758247375,
-0.029567059129476547,
0.005154705606400967,
-0.02888055332005024,
-0.01673651859164238,
0.004900224972516298,
0.03146086633205414,
0.03979361429810524,
0.008403767831623554,
-0.005787947215139866,
-0.005956614390015602,
0.03652679920196533,
-0.00915537215769291,
-0.05965491384267807,
-0.009090272709727287,
0.03811286389827728,
0.01623939350247383,
0.06320580095052719,
0.005737642757594585,
-0.002245936542749405,
0.03636109083890915,
-0.012913395650684834,
-0.03917812928557396,
0.005057055968791246,
-0.01320930290967226,
0.013907643966376781,
0.014357422478497028,
-0.02703409269452095,
-0.00601579574868083,
0.02660798653960228,
-0.029993165284395218,
0.0037136368919163942,
-0.051842961460351944,
0.07636775821447372,
-0.03155555576086044,
-0.02317546121776104,
-0.023305660113692284,
0.02433541789650917,
-0.011433858424425125,
0.015197799541056156,
-0.022358756512403488,
-0.05118012800812721,
-0.01004309393465519,
-0.03254980593919754,
0.0049919565208256245,
-0.007196465972810984,
-0.023684421554207802,
0.007060348521918058,
-0.017375677824020386,
-0.007847461849451065,
-0.020831875503063202,
-0.014724347740411758,
-0.046208884567022324,
-0.009930649772286415,
0.041900474578142166,
0.03259715065360069,
0.02344769611954689,
-0.059796951711177826,
0.04642194136977196,
0.04438609629869461,
0.02244161069393158,
-0.02575577236711979,
-0.040551137179136276,
-0.03527215123176575,
0.0634898766875267,
0.023222805932164192,
-0.02684471197426319,
-0.013067266903817654,
0.015233309008181095,
-0.04630357772111893,
-0.039201799780130386,
0.012084854766726494,
0.005412144586443901,
0.009037009440362453,
0.032833874225616455,
-0.06912394613027573,
-0.006598732899874449,
-0.06301642209291458,
-0.028288738802075386,
-0.040503792464733124,
-0.023767275735735893,
-0.022086521610617638,
-0.000467903446406126,
0.04701375588774681,
0.0602230578660965,
-0.008007251657545567,
0.0015461157308891416,
-0.021849796175956726,
0.0036751688458025455,
0.013883971609175205,
0.01754138618707657,
-0.042705342173576355,
0.0482684001326561,
-0.03643210977315903,
0.030940068885684013,
-0.047108445316553116,
0.01391948014497757,
0.022335084155201912,
-0.010250229388475418,
0.018500125035643578,
0.04119029641151428,
0.013150121085345745,
0.03053763508796692,
0.028975244611501694,
0.01622755639255047,
-0.005660707131028175,
0.0023642994929105043,
0.059134118258953094,
-0.019115611910820007,
-0.03193431720137596,
0.003550887806341052,
-0.012416270561516285,
-0.01858297921717167,
-0.0034266067668795586,
0.05075402185320854,
0.006551388185471296,
-0.014487622305750847,
0.028975244611501694,
-0.008380095474421978,
-0.003331916406750679,
0.02845444716513157,
-0.03837326169013977,
0.007717262953519821,
-0.04149804264307022,
0.02648962289094925,
0.023767275735735893,
0.03593498468399048,
0.02622922509908676,
0.0046368674375116825,
-0.01873685047030449,
0.019612736999988556,
-0.04407835379242897,
0.01635775715112686,
0.00099572807084769,
-0.03434891998767853,
-0.009321080520749092,
-0.035532549023628235,
0.0016866717487573624,
-0.0174348596483469,
0.0074272737838327885,
-0.03929649293422699,
-0.029354006052017212,
-0.012191381305456161,
0.008758856914937496,
-0.009143535979092121,
0.05326331779360771,
-0.031105777248740196,
0.029756439849734306,
0.015458198264241219,
-0.013931316323578358,
0.006598732899874449,
-0.029022589325904846,
-0.015529216267168522,
0.003127740230411291,
-0.08067616820335388,
0.02502192184329033,
-0.005986204836517572,
-0.04284738004207611,
0.005057055968791246,
0.004595440812408924,
-0.053926147520542145,
0.0030567224603146315,
0.01982579007744789,
0.05155888944864273,
-0.024157872423529625,
-0.034538302570581436,
-0.008894973434507847,
0.009291489608585835,
0.00018253782764077187,
-0.04720313474535942,
-0.03539051488041878,
-0.0364084355533123,
0.01596715860068798,
-0.027507543563842773,
0.044102028012275696,
0.01863032393157482,
0.04232658073306084,
0.012007919140160084,
0.03207635134458542,
0.06154872104525566,
-0.010753272101283073,
-0.025637410581111908,
-0.016168376430869102,
0.01425089593976736,
0.035840295255184174,
-0.0029857049230486155,
0.028241394087672234,
-0.045759107917547226,
-0.01596715860068798,
-0.03666883334517479,
-0.03231307864189148,
-0.011102442629635334,
-0.022098358720541,
-0.024903560057282448,
-0.013043594546616077,
-0.03162657469511032,
-0.03837326169013977,
0.023861965164542198,
0.05335800722241402,
-0.005947737023234367,
0.008948237635195255,
0.01176527515053749,
0.01210852712392807,
-0.005119196604937315,
0.004494831897318363,
-0.004642785992473364,
0.044670168310403824,
-0.03508277237415314,
-0.0009217513143084943,
0.006592814810574055,
-0.037236977368593216,
-0.010978161357343197,
0.03150821104645729,
-0.03034825436770916,
-0.04800800234079361,
0.011575894430279732,
0.02206284925341606,
0.03340201824903488,
-0.0059921229258179665,
0.013564391061663628,
0.015588397160172462,
0.02918829768896103,
0.034727681428194046,
0.024903560057282448,
-0.04580645263195038,
-0.020228223875164986,
-0.04346286505460739,
-0.029093606397509575,
-0.016452446579933167,
-0.014949237927794456,
0.019482538104057312,
-0.0008958593825809658,
-0.042634326964616776,
0.024205219000577927,
0.011723848059773445,
0.009469034150242805,
-0.031176794320344925,
0.027909977361559868,
-0.019802117720246315,
0.06907660514116287,
-0.018156873062253,
0.026702675968408585,
0.0010667458409443498,
-0.0023258314467966557,
-0.07191731035709381,
0.038775693625211716,
0.0007234934018924832,
-0.029756439849734306,
-0.007036676164716482,
-0.05245845019817352,
0.048528797924518585,
0.029022589325904846,
-0.0012583459028974175,
-0.010262065567076206,
0.01455864030867815,
0.03077436052262783,
0.01677202619612217,
0.010273901745676994,
-0.009137618355453014,
0.038467951118946075,
-0.0033970160875469446,
-0.04145069792866707,
0.02679736725986004,
-0.024430107325315475,
-0.048576146364212036,
-0.007918479852378368,
-0.004864716436713934,
0.011327331885695457,
0.0161210298538208,
0.012002000585198402,
0.060601819306612015,
0.003787613706663251,
0.05842394009232521,
-0.02324647828936577,
0.0244064349681139,
-0.04078786447644234,
-0.032407768070697784,
0.012487288564443588,
-0.0029945820569992065,
0.05193765088915825,
0.01474802102893591,
-0.034419938921928406,
0.04549871012568474,
0.030371926724910736,
0.02672634832561016,
-0.007521964143961668,
0.014073352329432964,
0.05170092731714249,
-0.017529549077153206,
-0.0015727473655715585,
0.004456364084035158,
-0.036384765058755875,
0.025471702218055725,
0.03759206458926201,
-0.045404016971588135,
-0.057050932198762894,
0.03413586691021919,
0.013197465799748898,
-0.041474368423223495,
-0.0006121582700870931,
0.012428107671439648,
-0.008391931653022766,
0.05558323115110397,
-0.021542051807045937,
0.07229607552289963,
0.05108543857932091,
-0.009788613766431808,
0.035461533814668655,
-0.05094340443611145,
-0.021920813247561455,
-0.06912394613027573,
0.01023839320987463,
-0.02783896028995514,
0.03976994380354881,
-0.015552888624370098,
0.006480370182543993,
-0.015410852618515491,
-0.041403353214263916,
-0.025661082938313484,
0.03482237458229065,
0.013765607960522175,
-0.02371993102133274,
-0.013765607960522175,
0.022299574688076973,
0.03176860883831978,
0.022915061563253403,
0.014546803198754787,
-0.004145661368966103,
-0.010368592105805874,
0.02819404937326908,
-0.04348653927445412,
-0.014629657380282879,
-0.013386846520006657,
0.04800800234079361,
0.0032875302713364363,
-0.01455864030867815,
-0.05108543857932091,
-0.028430774807929993,
0.07021288573741913,
-0.017020588740706444,
0.021814286708831787,
-0.03299958258867264,
0.04199516773223877,
-0.03621905669569969,
0.018097691237926483,
-0.028430774807929993,
0.03181595355272293,
-0.03115312196314335,
-0.009930649772286415,
0.030206218361854553,
-0.04450445994734764,
0.007261565420776606,
0.042634326964616776,
0.007368091959506273,
0.04746353253722191,
-0.036195382475852966,
-0.018346253782510757,
0.010469201020896435,
-0.03574560210108757,
0.018642161041498184,
0.01796749234199524,
0.011652830056846142,
-0.04488322138786316,
-0.021459197625517845,
-0.06983412802219391,
-0.0025684754364192486,
0.0002605833869893104,
-0.005521630402654409,
-0.005409185774624348,
0.020003333687782288,
-0.02888055332005024,
-0.018488289788365364,
0.048221055418252945,
0.02949604205787182,
0.00029276328859850764,
0.01893806830048561,
-0.012238726951181889,
0.004272901453077793,
-0.06292173266410828,
-0.040054015815258026,
-0.027010420337319374,
0.017955655232071877,
0.04007768630981445,
-0.019683754071593285,
-0.019068267196416855,
0.013978661969304085,
0.029874801635742188,
0.00846294965595007,
-0.009184963069856167,
-0.056009337306022644,
-0.023495040833950043,
0.03984096273779869,
0.0006221451330929995,
-0.027933649718761444,
-0.007450946141034365,
0.0063205803744494915,
0.00988922268152237,
-0.012984412722289562,
-0.011966492049396038,
0.016629990190267563,
-0.010025340132415295,
-0.003846795065328479,
-0.0006373103824444115,
-0.007658081129193306,
0.015162291005253792,
-0.029519714415073395,
0.02406318299472332,
-0.0011414624750614166,
0.035887639969587326,
0.01593164913356304,
0.028004668653011322,
0.03662148863077164,
0.021186964586377144,
-0.005512753501534462,
0.0285728108137846,
0.018985413014888763,
-0.016026340425014496,
-0.033993832767009735,
0.010765108279883862,
0.0410245917737484,
0.005086646880954504,
-0.02124614454805851,
0.0016245311126112938,
-0.047534551471471786,
-0.020606985315680504,
0.011208969168365002,
-0.0028717804234474897,
-0.03955689072608948,
0.006089772563427687,
-0.04403100907802582,
-0.007486455142498016,
0.04542769119143486,
-0.0016215720679610968,
-0.04985446482896805,
-0.006444861181080341,
-0.00817887857556343,
-0.01977844536304474,
0.016996916383504868,
-0.026087189093232155,
0.0023983288556337357,
0.008770693093538284,
-0.009392098523676395,
0.018381763249635696,
-0.03543785959482193,
0.014641493558883667,
-0.016558973118662834,
-0.058944735676050186,
0.005675502121448517,
0.021837959066033363,
0.013517046347260475,
-0.006610569544136524,
0.0031632492318749428,
0.005764274392277002,
-0.006723014172166586,
-0.0291172806173563,
0.009261898696422577,
-0.007149120792746544,
0.030253563076257706,
-0.018831541761755943,
0.017056098207831383,
0.0010223598219454288,
0.02116329036653042,
0.01461782120168209,
-0.005580811761319637,
-0.028004668653011322,
-0.007699508219957352,
-0.017269151285290718,
-0.02487988770008087,
-0.011717929504811764,
0.0023228724021464586,
-0.032100025564432144,
0.018559306859970093,
0.009859631769359112,
-0.00815520528703928,
-0.01095448900014162,
-0.054778363555669785,
0.053926147520542145,
-0.009019254706799984,
0.00749237323179841,
-0.010291656479239464,
-0.03143719211220741,
0.039036091417074203,
0.0029457572381943464,
0.0231399517506361,
-0.013244811445474625,
0.0024871008936315775,
0.040740519762039185,
-0.03692923113703728,
-0.00846294965595007,
-0.04287105053663254,
0.056009337306022644,
0.02124614454805851,
0.016724681481719017,
-0.05283721163868904,
-0.0009491227101534605,
-0.0056784613989293575,
-0.0163459200412035,
0.02344769611954689,
0.016440611332654953,
0.022157540544867516,
-0.0296144038438797,
-0.020583312958478928,
0.017304658889770508,
0.006101608742028475,
-0.026821039617061615,
0.01754138618707657,
0.026087189093232155,
-0.013505210168659687,
0.025424355641007423,
-0.004897266160696745,
-0.03557989373803139,
-0.035343170166015625,
0.06277969479560852,
0.010149620473384857,
-0.02324647828936577,
-0.008409685455262661,
0.0001623791322344914,
0.03524848073720932,
0.00240572658367455,
-0.01716262474656105,
0.005595607217401266,
0.037497375160455704,
-0.0007604818092659116,
0.036952905356884,
0.021968159824609756,
0.027436526492238045,
0.0003715486091095954,
-0.0191984660923481,
0.02413420006632805,
0.02148287184536457,
-0.00836825929582119,
-0.02452479861676693,
-0.051890306174755096,
0.0019263565773144364,
-0.030324582010507584,
0.0013352817622944713,
0.022500792518258095,
-0.001568308798596263,
0.001868654740974307,
0.018369926139712334,
0.041971493512392044,
0.004568809177726507,
-0.050185881555080414,
0.02641860581934452,
-0.016405101865530014,
0.008137451484799385,
0.015955323353409767,
-0.01058164518326521,
0.025163957849144936,
-0.009451279416680336,
-0.026016172021627426,
0.024051345884799957,
0.0017473327461630106,
-0.021530216559767723,
0.0023435859475284815,
-0.005956614390015602,
-0.0207845289260149,
-0.0022991998121142387,
-0.033686090260744095,
0.0011325852246955037,
-0.007900725118815899,
0.03134250268340111,
0.016168376430869102,
0.014736183919012547,
-0.0004834385763388127,
0.040243394672870636,
0.04422038793563843,
-0.008563557639718056,
0.009830040857195854,
0.010475118644535542,
0.007439109962433577,
-0.020334750413894653,
-0.0016452446579933167,
0.002272568177431822,
-0.0018494207179173827,
0.01471251156181097,
-0.0030419272370636463,
0.04097724333405495,
0.019541719928383827,
0.001475097960792482,
-0.013351337984204292,
-0.003769859205931425,
0.0056340754963457584,
-0.013481536880135536,
-0.03165024518966675,
-0.009865550324320793,
0.001100775203667581,
-0.02672634832561016,
-0.0025092940777540207,
-0.02413420006632805,
-0.012226889841258526,
-0.00007749073120066896,
0.006675668992102146,
0.032029006630182266,
0.014677003026008606,
0.002549241529777646,
-0.00677627744153142,
0.01474802102893591,
-0.028856880962848663,
0.012735851109027863,
-0.03692923113703728,
-0.019506210461258888,
0.022725682705640793,
-0.001172532793134451,
-0.03437259420752525,
-0.01758873090147972,
0.00933291669934988,
-0.003133658552542329,
0.013647245243191719,
0.040929898619651794,
-0.04715579003095627,
0.02814670465886593,
0.004485954996198416,
-0.034230560064315796,
-0.0015845836605876684,
0.034230560064315796,
0.012866050004959106,
-0.022110193967819214,
0.0010519505012780428,
-0.017766274511814117,
-0.007285238243639469,
0.0004053930169902742,
0.013232975266873837,
0.030750688165426254,
0.009108027443289757,
-0.022974243387579918,
0.017269151285290718,
0.025305993854999542,
-0.0004708625201601535,
0.0072556473314762115,
0.010788780637085438,
0.054399602115154266,
0.029259314760565758,
-0.0592288076877594,
0.028596483170986176,
-0.017553221434354782,
-0.004953488241881132,
-0.01619204878807068,
-0.015529216267168522,
-0.03832591697573662,
-0.025187630206346512,
-0.007705426309257746,
0.018074018880724907,
-0.02332933247089386,
-0.020263733342289925,
-0.005015628878027201,
-0.009362507611513138,
0.010427773930132389,
-0.015789614990353584,
-0.009338835254311562,
0.003524256171658635,
0.020098024979233742,
0.006356088910251856,
0.007178711239248514,
0.004145661368966103,
-0.01885521411895752,
-0.0012428107438609004,
0.025400683283805847,
0.008386013098061085,
-0.014310077764093876,
-0.007078102789819241,
-0.018417270854115486,
-0.05941819027066231,
0.006947903893887997,
0.005779069848358631,
-0.02532966621220112,
-0.02648962289094925,
0.010747353546321392,
0.005864882841706276,
0.005003792699426413,
0.027909977361559868,
0.004193006549030542,
0.013907643966376781,
0.00709585752338171,
0.02580311708152294,
-0.020109860226511955,
-0.002416083123534918,
-0.036313746124506,
-0.02309260703623295,
0.03254980593919754,
-0.029874801635742188,
0.018606651574373245,
0.0018139118328690529,
-0.02923564240336418,
0.004471159540116787,
-0.029827456921339035,
-0.026939401403069496,
-0.009054764173924923,
0.00387934478931129,
-0.009954322129487991,
0.0023287904914468527,
0.00942760705947876,
-0.009415770880877972,
-0.018949903547763824,
0.03733166679739952,
-0.01573043316602707,
-0.01526881754398346,
-0.033993832767009735,
0.019955988973379135,
-0.028052013367414474,
0.0001055094544426538,
-0.022607319056987762,
0.0400303415954113,
0.046682339161634445,
-0.06088588759303093,
-0.03136617690324783,
-0.0110491793602705,
-0.014085188508033752,
0.002441235352307558,
0.00971759669482708,
-0.017174459993839264,
0.007521964143961668,
0.01670100912451744,
-0.03420688584446907,
-0.012771359644830227,
-0.02630024217069149,
0.0404801219701767,
-0.01784912869334221,
-0.002324352040886879,
-0.008676002733409405,
0.01762424036860466,
-0.05918146297335625,
-0.03077436052262783,
0.017245478928089142,
-0.023625239729881287,
-0.00037469263770617545,
-0.03404117748141289,
0.052269067615270615,
0.009303325787186623,
-0.004610235802829266,
0.008362340740859509,
0.007273401599377394,
-0.04739251732826233,
-0.049144286662340164,
-0.022346921265125275,
0.0014144369633868337,
-0.04244494438171387,
0.02838343009352684,
-0.01149304024875164,
-0.03134250268340111,
0.00439718272536993,
-0.004947570152580738,
-0.009439443238079548,
-0.01639326475560665,
-0.008149287663400173,
0.002815558109432459,
0.01299624890089035,
0.027436526492238045,
-0.03643210977315903,
-0.0291172806173563,
-0.033378344029188156,
0.0013722701696678996,
0.018618488684296608,
-0.018902558833360672,
0.015789614990353584,
-0.020583312958478928,
-0.04040910303592682,
-0.01635775715112686,
0.0014795365277677774,
-0.026087189093232155,
-0.004740435164421797,
0.024785196408629417,
0.010913061909377575,
-0.004287696909159422,
-0.015458198264241219,
0.035958655178546906,
0.011629157699644566,
-0.02143552526831627,
-0.022193048149347305,
0.008107860572636127,
-0.009486788883805275,
0.03413586691021919,
-0.020725348964333534,
-0.011534467339515686,
0.017872801050543785,
-0.0037313911598175764,
-0.039580561220645905,
0.030064182355999947,
0.02575577236711979,
-0.02325831539928913,
-0.013789281249046326,
0.02086738310754299,
-0.015185963362455368,
0.020606985315680504,
-0.03352038189768791,
-0.007811953313648701,
0.0011281466577202082,
0.01577777788043022,
-0.004195965826511383,
-0.009196799248456955,
-0.008107860572636127,
-0.010930816642940044,
0.004799616523087025,
-0.00034140306524932384,
0.019577227532863617,
0.008101942017674446,
0.004894306883215904,
-0.0029398391488939524,
0.021317163482308388,
-0.01048695482313633,
-0.03413586691021919,
-0.01320930290967226,
-0.021778779104351997,
-0.0012280154041945934,
0.04966508224606514,
-0.023684421554207802,
-0.013173793442547321,
-0.04182945936918259,
-0.034798700362443924,
0.013067266903817654,
0.00181687087751925,
0.018985413014888763,
0.012581978924572468,
-0.012321580201387405,
0.010617154650390148,
-0.008841710165143013,
-0.003778736339882016,
-0.028714844956994057,
0.0014085188740864396,
0.008782529272139072,
0.020263733342289925,
0.012889722362160683,
0.035224806517362595,
-0.0053914315067231655,
0.0633951798081398,
0.01786096580326557,
-0.0354141891002655,
-0.031602900475263596,
-0.015955323353409767,
-0.044977910816669464,
0.006586896721273661,
0.010930816642940044,
-0.010149620473384857,
0.004231474827975035,
0.015351671725511551,
0.004521463997662067,
0.0053115361370146275,
0.006947903893887997,
0.0007186848670244217,
0.02286771684885025,
0.00959923304617405,
0.03330732882022858,
0.00628507137298584,
0.005684379488229752,
-0.008782529272139072,
-0.01569492369890213,
-0.02194448560476303,
0.00827356893569231,
0.030632324516773224,
-0.02360156737267971,
-0.022607319056987762,
0.0016319288406521082,
0.010031257756054401,
0.014475786127150059,
0.012061182409524918,
0.025092940777540207,
0.02876219153404236,
0.05378411337733269,
-0.01174160186201334,
-0.0043439194560050964,
0.01820421777665615,
-0.017103442922234535,
-0.027081437408924103,
0.01673651859164238,
-0.027318162843585014,
0.03690556064248085,
-0.014026006683707237,
-0.03560356795787811,
-0.004074643831700087,
-0.001589022227562964,
-0.016132866963744164,
0.01079469919204712,
0.025092940777540207,
0.011001833714544773,
0.011700175702571869,
-0.027554888278245926,
0.037189632654190063,
-0.04495424032211304,
-0.03328365460038185,
0.01551737915724516,
-0.01747036725282669,
0.016831208020448685,
0.021269816905260086,
0.020311078056693077,
-0.04059848189353943,
0.027933649718761444,
-0.0027756106574088335,
0.013351337984204292,
0.041971493512392044,
-0.05383145809173584,
-0.008942319080233574,
-0.026560639962553978,
0.035343170166015625,
-0.009557805955410004,
0.01831074431538582,
-0.015434525907039642,
0.002768212929368019,
0.039083439856767654,
0.031981661915779114,
-0.02452479861676693,
-0.02630024217069149,
0.029330333694815636,
-0.03162657469511032,
-0.0061371177434921265,
-0.03924914449453354,
0.041048262268304825,
0.047723930329084396,
-0.03257347643375397,
-0.024288073182106018,
0.018535634502768517,
-0.00557193486019969,
-0.04942835867404938,
-0.021613070741295815,
0.041403353214263916,
0.0006284331320784986,
0.03285754844546318,
-0.025282321497797966,
0.023400351405143738,
0.03733166679739952,
0.0015387180028483272,
0.0073207467794418335,
0.010889389552175999,
-0.05056464299559593,
-0.013647245243191719,
-0.01122080534696579,
-0.037544719874858856,
0.014487622305750847,
0.003595273941755295,
-0.0358639657497406,
0.019754773005843163,
0.030182546004652977,
0.04258698225021362,
-0.023435859009623528,
0.012806868180632591,
0.007705426309257746,
0.03775777295231819,
0.020891057327389717,
0.010244310833513737,
0.005758356302976608,
0.02201550453901291,
-0.008261731825768948,
-0.03285754844546318,
0.012439943850040436,
-0.02973276749253273,
0.05529915913939476,
0.046137869358062744,
0.006018754560500383,
-0.024051345884799957,
-0.005607443396002054,
0.016689172014594078,
0.058329250663518906,
-0.003985871560871601,
-0.03188697248697281,
-0.0014077790547162294,
-0.011522631160914898,
0.017067933455109596,
0.004429732449352741,
-0.002225222997367382,
0.04007768630981445,
0.009883304126560688,
0.034680336713790894,
0.028028341010212898,
-0.0011532987700775266,
-0.0012879365822300315,
-0.002345065586268902,
-0.012262399308383465,
-0.006444861181080341,
0.006782195530831814,
0.012913395650684834,
-0.012451780028641224,
-0.007930316030979156,
-0.026394931599497795,
0.014168042689561844,
0.017943819984793663,
0.02251262776553631,
0.014677003026008606,
0.010960406623780727,
-0.012321580201387405,
-0.0016200925456359982,
-0.019565392285585403,
0.019233975559473038,
0.009297408163547516,
0.020263733342289925,
-0.022051014006137848,
-0.0173875130712986,
-0.003169167321175337,
-0.011818538419902325,
0.012641160748898983,
0.01789647527039051,
0.03574560210108757,
-0.017943819984793663,
-0.029993165284395218,
-0.020962074398994446,
-0.008563557639718056,
-0.018689505755901337,
0.02985112927854061,
-0.02283220924437046,
-0.010250229388475418,
-0.004920938517898321,
-0.03557989373803139,
0.009119863621890545,
-0.004429732449352741,
-0.015008418820798397,
-0.007089939434081316,
0.006989330984652042,
0.051227472722530365,
-0.03236042335629463,
-0.016203884035348892,
-0.00021971117530483752,
-0.005119196604937315,
-0.007806034758687019,
-0.004926856607198715,
0.026963073760271072,
-0.002516691805794835,
-0.046208884567022324,
0.05203234404325485,
0.024193381890654564,
-0.018606651574373245,
0.0063975160010159016,
0.008575393818318844,
-0.000002895499392252532,
0.01299624890089035,
0.03413586691021919,
0.016026340425014496,
0.0004501490038819611,
0.006912394892424345,
0.0045333001762628555,
-0.022536301985383034,
-0.05634075403213501,
-0.0017014670884236693,
0.02251262776553631,
0.0028806577902287245,
-0.0018094732658937573,
-0.018287071958184242,
0.042515963315963745,
-0.017138952389359474,
-0.0020225264597684145,
-0.01835808902978897,
0.0031898808665573597,
-0.013966824859380722,
-0.0027253064326941967,
-0.007332583423703909,
0.012605651281774044,
0.00669934181496501,
0.002669083885848522,
0.030916396528482437,
0.04152171313762665,
0.008604984730482101,
0.011948737315833569,
-0.001397422282025218,
0.004897266160696745,
-0.012215053662657738,
-0.005048178602010012,
-0.008084188215434551,
0.04975977540016174,
-0.0036722098011523485,
-0.03236042335629463,
0.03984096273779869,
0.03721330314874649,
0.011871801689267159,
-0.012487288564443588,
-0.00971759669482708,
-0.023435859009623528,
0.00013593242329079658,
-0.010942652821540833,
0.017363840714097023,
0.018417270854115486,
-0.015529216267168522,
0.01139834988862276,
0.023376677185297012,
-0.007101775612682104,
0.01070000883191824,
0.002525568939745426,
-0.011919146403670311,
0.025353338569402695,
0.0296144038438797,
-0.04253963381052017,
0.0025714344810694456,
0.007018921431154013,
0.024690506979823112,
0.04923897609114647,
0.01480720192193985,
-0.019387846812605858,
0.04590114206075668,
0.0017591690411791205,
-0.0063146622851490974,
0.0030360091477632523,
-0.03581662103533745,
-0.003547928761690855,
-0.024477453902363777,
-0.024737851694226265,
-0.013860298320651054,
0.02387380227446556,
0.026205552741885185,
0.011895474046468735,
-0.02660798653960228,
-0.016050012782216072,
-0.028667500242590904,
-0.03041927143931389,
0.016712844371795654,
-0.03508277237415314,
-0.002237059408798814,
-0.013741935603320599,
0.03162657469511032,
-0.024264398962259293,
0.007569309324026108,
0.015422689728438854,
-0.0025063350331038237,
-0.009759022854268551,
0.01465333066880703,
0.010546136647462845,
0.024785196408629417,
0.012581978924572468,
0.005341127049177885,
-0.005782029125839472,
0.001658560475334525,
-0.04535667225718498,
0.016783863306045532,
-0.020275568589568138,
0.0065040430054068565,
0.016641827300190926,
-0.00508072879165411,
-0.025163957849144936,
-0.02399216592311859,
0.040929898619651794,
-0.005388472229242325,
-0.001214699586853385,
0.018902558833360672,
-0.029780112206935883,
0.0045658499002456665,
0.00677627744153142,
0.014132533222436905,
-0.02618187852203846,
-0.006930149160325527,
0.02660798653960228,
0.017304658889770508,
0.012913395650684834,
-0.016215721145272255,
-0.022394265979528427,
-0.01560023333877325,
-0.011055096983909607,
-0.013706427067518234,
-0.021837959066033363,
0.030371926724910736,
-0.0005418802611529827,
-0.0026764816138893366,
0.045333001762628555,
-0.020382095128297806,
0.007782362401485443,
-0.015280653722584248,
-0.020311078056693077,
-0.018109528347849846,
0.012735851109027863,
0.022808535024523735,
0.012309744022786617,
0.025590064004063606,
0.007089939434081316,
-0.0015638701152056456,
-0.029354006052017212,
0.010546136647462845,
-0.0404801219701767,
-0.03108210489153862,
0.0051754191517829895,
0.0023554221261292696,
-0.037615738809108734,
-0.03370976075530052,
-0.0031869218219071627,
-0.01004309393465519,
0.013339501805603504,
0.008652329444885254,
-0.005432858131825924,
-0.007332583423703909,
-0.01750587671995163,
-0.005018588155508041,
-0.018902558833360672,
0.009380262345075607,
0.017091605812311172,
0.025637410581111908,
0.0343252494931221,
-0.03806551545858383,
0.046256233006715775,
0.010836126282811165,
0.018026674166321754,
-0.021044928580522537,
-0.020654330030083656,
-0.0007693590014241636,
-0.004654622171074152,
-0.012250563129782677,
-0.0006040207808837295,
0.01631041057407856,
-0.020772693678736687,
-0.00997207686305046,
0.058092523366212845,
-0.0034295658115297556,
-0.021340835839509964,
0.003944444470107555,
-0.011274068616330624,
-0.007018921431154013,
-0.0006872447556816041,
0.026963073760271072,
-0.01885521411895752,
-0.011356922797858715,
-0.02251262776553631,
-0.023353004828095436,
-0.006409352645277977,
0.026465950533747673,
0.03245511278510094,
-0.010309411212801933,
0.0017517713131383061,
-0.014487622305750847,
-0.04246861860156059,
-0.07793015241622925,
0.01812136359512806,
0.024311745539307594,
-0.02148287184536457,
0.01784912869334221,
0.001886409125290811,
0.030750688165426254,
0.026868384331464767,
0.0010297574335709214,
0.0008211428066715598,
0.03995932266116142,
0.021802451461553574,
-0.009800449945032597,
-0.000587745918892324,
0.02776794321835041,
0.02949604205787182,
-0.03302325680851936,
-0.015138618648052216,
-0.003544969717040658,
-0.04232658073306084,
0.027081437408924103,
-0.012913395650684834,
-0.0001901204523164779,
0.03297591209411621,
-0.007421355694532394,
0.019837627187371254,
0.0028111194260418415,
-0.016748353838920593,
0.03726064786314964,
-0.04033808410167694,
-0.0034295658115297556,
-0.024737851694226265,
-0.02930666133761406,
-0.020027007907629013,
0.01993231661617756,
-0.011132033541798592,
-0.024240726605057716,
0.0033763025421649218,
-0.0035124197602272034,
0.03797082602977753,
-0.009711678139865398,
0.0026158206164836884,
-0.00006865974137326702,
0.03953321650624275,
-0.0034295658115297556,
0.0031957989558577538,
-0.02838343009352684,
-0.00950454268604517,
-0.0053914315067231655,
0.026892056688666344,
-0.013138284906744957,
-0.012090773321688175,
0.005290822591632605,
-0.02035842277109623,
0.005690297577530146,
-0.013232975266873837,
-0.008646411821246147,
0.03143719211220741,
-0.003965158015489578,
-0.02309260703623295,
0.0003451019001659006,
-0.005897432565689087,
-0.011564058251678944,
0.0015372384805232286,
-0.0026557680685073137,
-0.026584312319755554,
-0.00878844689577818,
-0.001247249310836196,
0.01731649599969387,
-0.003148453775793314,
0.014499458484351635,
0.02580311708152294,
-0.037426356226205826,
-0.005006751976907253,
-0.017730766907334328,
-0.010475118644535542,
0.030206218361854553,
-0.0034621155355125666,
-0.008687838912010193,
-0.009735350497066975,
0.01320930290967226,
0.01120305061340332,
0.0003942964831367135,
-0.05941819027066231,
-0.01554105244576931,
0.016523463651537895,
0.006184462923556566,
0.03165024518966675,
0.04133233428001404,
0.00861682090908289,
0.02371993102133274,
-0.03505909815430641,
0.015860632061958313,
0.015292489901185036,
0.02421705424785614,
-0.011386513710021973,
-0.014404768124222755,
0.015339835546910763,
0.016381429508328438,
0.005116237327456474,
-0.0021601233165711164,
-0.0291172806173563,
0.022264067083597183,
-0.0026942361146211624,
0.017091605812311172,
0.0027208677493035793,
0.012783195823431015,
-0.003976994194090366,
0.006930149160325527,
-0.04261065274477005,
0.004725639708340168,
0.023684421554207802,
-0.0034384429454803467,
0.010125948116183281,
0.02954338677227497,
0.008338668383657932,
-0.019719263538718224,
-0.013694590888917446,
0.04244494438171387,
-0.03678719699382782,
-0.02324647828936577,
0.059370845556259155,
-0.01193690113723278,
-0.0312004666775465,
0.014759857207536697,
0.04225556552410126,
-0.01584879495203495,
0.001493592164479196,
-0.02356605790555477,
-0.025542719289660454,
-0.004648704081773758,
-0.05236375704407692,
0.020453114062547684,
0.024359090253710747,
0.00587080093100667,
0.010498791933059692,
0.03444361314177513,
-0.05482570827007294,
0.016641827300190926,
0.003010856918990612,
-0.006918312981724739,
-0.006794032175093889,
-0.004438609816133976,
-0.03799450024962425,
-0.006421188823878765,
0.027247145771980286,
0.016050012782216072,
0.04346286505460739,
0.016334082931280136,
-0.04258698225021362,
0.01692589931190014,
-0.05118012800812721,
-0.028714844956994057,
0.008800284005701542,
-0.024075018242001534,
-0.005509794224053621,
0.008072351105511189,
0.02606351673603058,
0.004071684554219246,
0.01201383676379919,
0.012641160748898983,
0.008042761124670506,
0.03446728363633156,
-0.014392931945621967,
0.014333750121295452,
-0.017304658889770508,
-0.026773693040013313,
0.10075052082538605,
-0.007397682871669531,
0.004249229095876217,
-0.010723681189119816,
0.0032608986366540194,
-0.008161123842000961,
0.01425089593976736,
-0.0018287071725353599,
0.0024397557135671377,
-0.006433025002479553,
0.03621905669569969,
0.029567059129476547,
0.011404267512261868,
0.020121697336435318,
0.04616153985261917,
-0.013907643966376781,
0.0001943741226568818,
0.034301575273275375,
-0.004281778819859028,
-0.018985413014888763,
0.022725682705640793,
0.04483587667346001,
-0.020678002387285233,
0.028738519176840782,
-0.018796032294631004,
-0.010415937751531601,
0.011232641525566578,
0.01551737915724516,
-0.005654788576066494,
-0.01299624890089035,
0.017754439264535904,
0.01707977056503296,
0.04071684554219246,
-0.026347586885094643,
-0.004787780344486237,
0.014771693386137486,
0.002882137196138501,
0.006782195530831814,
-0.014392931945621967,
0.02869117259979248,
0.0036899643018841743,
-0.005995082203298807,
-0.014854547567665577,
0.022761190310120583,
-0.0012908956268802285,
-0.0013966825790703297,
-0.03529582545161247,
-0.015197799541056156,
0.03666883334517479,
-0.011925064958631992,
0.005071851424872875,
0.006468534003943205,
0.02672634832561016,
-0.020382095128297806,
-0.048221055418252945,
0.007711344864219427,
0.013872134499251842,
-0.01132141426205635,
-0.02305709756910801,
-0.027247145771980286,
0.02274935506284237,
0.01554105244576931,
0.002490060171112418,
-0.027270818129181862,
0.00485879834741354
] | 2025-01-22 | 61 | 39837618 | [
"TIL immunotherapy",
"TIL manufacturing",
"TIL",
"clinical practice guidelines",
"underlying clinical rationale",
"patients",
"required resources",
"cellular immunotherapy",
"durable tumor regression",
"T cells",
"sufficient tumor",
"effector T cell products",
"hospital inpatient resources",
"non-myeloablative lymphodepleting chemotherapy",
"chimeric antigen receptor",
"immune checkpoint inhibitors",
"patient access",
"autologous tumor-infiltrating T lymphocytes",
"hematological malignancies",
"practice",
"solid cancers",
"centers",
"intravenous interleukin-2",
"the clinical expertise",
"clinical and research settings",
"the National Cancer Institute Surgery Branch",
"metastatic melanoma",
"CAR",
"this promising treatment modality",
"many complex and unique aspects"
] | [
"Adoptive cell therapy - ACT",
"Cytokine",
"Immunotherapy",
"Surgery",
"Tumor infiltrating lymphocyte - TIL"
] | 0 | 10.1136/jitc-2024-010207
10.1126/science.aad1253
10.1172/JCI82416
10.1016/j.ccell.2023.11.005
10.1016/j.immuni.2023.09.011
10.1126/science.3489291
10.1056/NEJM198812223192527
10.1126/science.1076514
10.1158/1078-0432.CCR-21-1171
10.1093/annonc/mdz398
10.1056/NEJMoa2210233
10.1136/jitc-2023-008372
10.1136/jitc-2022-005755
10.1136/jitc-2022-SITC2022.0789
10.1136/jitc-2023-008735
10.1038/s41591-021-01462-y
10.1158/1078-0432.CCR-18-2722
10.1136/jitc-2021-003499
10.1136/jitc-2023-006822
10.1038/ni.3682
10.1158/2159-8290.CD-18-1494
10.1200/JCO.21.02170
10.1126/science.1251102
10.1038/s41591-018-0040-8
10.1056/NEJMoa1609279
10.1038/d41573-023-00206-6
10.1158/1078-0432.CCR-12-1177
10.1158/1078-0432.CCR-15-1879
10.1200/JCO.2008.16.5449
10.4049/jimmunol.176.12.7726
10.1158/1078-0432.CCR-11-0116
10.1126/science.abb9847
10.1200/JCO.2012.46.6441
10.1158/1078-0432.CCR-21-4499
10.1172/JCI150535
10.1158/1078-0432.CCR-21-1060
10.1038/s41467-017-01460-0
10.1126/sciimmunol.adg7995
10.1182/blood-2011-10-386482
10.1016/j.ymthe.2020.06.025
10.1097/PPO.0000000000000608
10.1097/CJI.0b013e3181f05b91
10.1245/s10434-009-0677-0
10.1016/j.jtcvs.2010.05.020
10.1097/00000658-199809000-00004
10.1200/JCO.2005.00.240
10.1136/jitc-2020-001743
10.1200/JCO.21.00612
10.1097/00002371-200107000-00004
10.1186/s40425-014-0026-0
10.1056/NEJM199004053221404
10.1158/1078-0432.CCR-22-2428
10.1200/JCO.2016.66.7220
10.1016/j.ophtha.2008.12.004
10.1016/j.iotech.2023.100538
10.1245/s10434-016-5537-0
10.1007/978-3-030-75537-9_35
10.1111/trf.17703
10.1038/s41409-022-01866-5
10.1038/d41573-022-00095-1
10.1136/jitc-2020-002056
10.1097/CJI.0b013e31826e8f5f
10.1158/1078-0432.CCR-10-0041
10.1158/1078-0432.CCR-17-3649
10.1158/2159-8290.CD-23-1334
10.1200/JCO.2019.37.15_suppl.2538 | [
"Turcotte",
"Donia",
"Gastman",
"Besser",
"Brown",
"Coukos",
"Creelan",
"Mullinax",
"Sondak",
"Yang",
"Rohaan",
"Marie Svane",
"Lotze",
"Haanen",
"Goff"
] | [
"Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.",
"Department of Oncology, National Center for Cancer Immune Therapy, Copenhagen University Hospital, Herlev, Denmark.",
"Iovance Biotherapeutics, Philadelphia, Pennsylvania, USA.",
"Davidoff Center & Samueli Institute, Rabin Medical Center, Petach Tikva, Israel.\nSchool of Medicine, Tel Aviv University, Tel Aviv, Israel.",
"Zai Laboratory, Chicago, Illinois, USA.",
"University Hospital of Lausanne, and Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland.",
"H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.",
"H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.",
"H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida, USA.",
"Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.",
"Netherlands Cancer Institute, Amsterdam, The Netherlands.",
"Department of Oncology, National Center for Cancer Immune Therapy, Copenhagen University Hospital, Herlev, Denmark.",
"University of Pittsburgh, Pittsburgh, Pennsylvania, USA.",
"Netherlands Cancer Institute, Amsterdam, The Netherlands.\nMedical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.\nLeiden University Medical Center, Leiden, The Netherlands.\nCentre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.",
"Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA [email protected].\nSurgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA."
] | [
"39837618",
"26516200",
"26389673",
"38039963",
"37820582",
"3489291",
"3264384",
"12242449",
"34413159",
"31566658",
"36477031",
"38531663",
"36600653",
"38423748",
"34385708",
"30518633",
"34607899",
"38309721",
"28198830",
"31164343",
"35104158",
"24812403",
"29867227",
"27959684",
"38093023",
"23032743",
"27006492",
"18809613",
"16751420",
"21498393",
"33303615",
"23650429",
"35247926",
"34813506",
"35190823",
"29170503",
"38306416",
"22555974",
"32615068",
"35880938",
"20842052",
"19777192",
"20584535",
"9742914",
"33990415",
"33979178",
"11565830",
"31546315",
"2156163",
"37058256",
"27217459",
"19410956",
"27638681",
"38173340",
"36347999",
"35650421",
"33846220",
"22996367",
"20406835",
"29848573",
"38563600"
] | [] | 10.194453 | 4.454338 |
39836430 | 9 | Population Pharmacokinetics of Orvacabtagene Autoleucel, an Autologous BCMA-Directed Chimeric Antigen Receptor T-Cell Product, in Patients with Relapsed/Refractory Multiple Myeloma. | Orvacabtagene autoleucel (orva-cel; JCARH125), a CAR T-cell therapy targeting B-cell maturation antigen (BCMA), was evaluated in relapsed/refractory multiple myeloma (RRMM) patients in the EVOLVE phase 1/2 study (NCT03430011). We applied a modified piecewise model to characterize orva-cel transgene kinetics and assessed the impact of various covariates on its pharmacokinetics (PK).
The population PK analysis included 159 patients from the EVOLVE study. Traditional piecewise models, employing a first-order expansion rate with or without lag time followed by a bi-exponential contraction phase, were compared with a modified model incorporating a cell number-dependent expansion phase aligned with cellular physiology. Covariates assessed encompassed baseline demographics, dose levels (50 to 600 × 106 CD3+ CAR+ T cells), prior/concomitant medications, baseline disease burden, and anti-therapeutic antibody (ATA) status.
Traditional piecewise models failed to accurately describe maximum orva-cel transgene level (Cmax) and underestimated the time to Cmax (Tmax). Our modified model incorporating a cell number-dependent expansion rate outperformed traditional models by 1) more accurately capturing the cellular expansion phase, and 2) yielding a Tmax that closely matches observed values. Additionally, dose level, percentage of plasma cells in bone marrow, and treatment-induced ATA were identified as statistically significant covariates and associated with orva-cel expansion and/or persistence.
Orva-cel PK were adequately described by the modified piecewise model incorporating a cell number-dependent expansion phase, which aligns closely with T cell biology. | [
0.03012278489768505,
0.003520004218444228,
0.03740132227540016,
0.01596098765730858,
-0.0707135796546936,
-0.016887841746211052,
-0.00018017446564044803,
-0.004307149443775415,
0.0290868878364563,
-0.012062744237482548,
0.00372104998677969,
-0.027914689853787422,
-0.043153274804353714,
0.012015038169920444,
0.04808741435408592,
0.009718346409499645,
0.058391861617565155,
-0.00029496647766791284,
-0.03448445349931717,
0.02306233160197735,
-0.03647446632385254,
-0.022639794275164604,
0.031458545476198196,
-0.002594853052869439,
-0.057301443070173264,
-0.03333951532840729,
0.00703319301828742,
0.022176366299390793,
-0.0038164614234119654,
-0.030150044709444046,
0.004736501257866621,
-0.028487158939242363,
-0.022012803703546524,
-0.028050990775227547,
-0.08303529769182205,
-0.02313048206269741,
0.0812361091375351,
0.0011994593078270555,
-0.021004168316721916,
0.020867865532636642,
0.002937312237918377,
-0.01660160720348358,
0.03181293234229088,
0.09181315451860428,
-0.03132224455475807,
-0.007108159363269806,
-0.04601562023162842,
-0.06831465661525726,
0.015511189587414265,
-0.010386227630078793,
-0.01592009700834751,
0.0006930114468559623,
-0.04181751236319542,
0.02949579432606697,
-0.05430279299616814,
0.018264494836330414,
-0.004896656144410372,
0.028541678562760353,
-0.016165440902113914,
0.0013229831820353866,
0.026551667600870132,
-0.02182198129594326,
0.02845989726483822,
-0.02835085615515709,
-0.014802418649196625,
0.003373479237779975,
-0.05471169948577881,
0.0038846125826239586,
-0.0038062387611716986,
0.0050261435098946095,
-0.04489794373512268,
0.006917336490005255,
-0.010304445400834084,
0.0043412246741354465,
0.030886076390743256,
-0.002705598482862115,
-0.005959813483059406,
0.024398092180490494,
-0.035656653344631195,
0.004126548767089844,
0.020595261827111244,
-0.022980550304055214,
0.018278123810887337,
-0.02982291951775551,
0.03129498288035393,
-0.012594322673976421,
0.04328957572579384,
-0.021576637402176857,
0.02176745980978012,
-0.0034808171913027763,
-0.05615650489926338,
0.008600668050348759,
-0.04421643167734146,
0.00912543199956417,
0.011067737825214863,
0.014993241056799889,
-0.007510250899940729,
-0.07038645446300507,
0.03404828906059265,
0.034920621663331985,
-0.0002140370343113318,
0.02130403369665146,
0.023334935307502747,
0.005803065840154886,
0.055093348026275635,
0.009629749692976475,
-0.0565926693379879,
-0.0012096819700673223,
-0.009452557191252708,
-0.014652485959231853,
0.05078619718551636,
-0.022517122328281403,
-0.01266928855329752,
0.03868256136775017,
-0.031731151044368744,
-0.024793369695544243,
-0.053157854825258255,
0.005118147470057011,
-0.009214028716087341,
-0.011606131680309772,
-0.04631548374891281,
-0.009793312288820744,
0.011749248951673508,
-0.02642899565398693,
0.016329003497958183,
-0.01082239393144846,
0.03268526494503021,
-0.006586803589016199,
-0.007312612608075142,
-0.030531691387295723,
0.010072732344269753,
-0.021494856104254723,
0.029250450432300568,
-0.029877441003918648,
-0.08412571251392365,
0.024016447365283966,
0.005806473549455404,
0.006341459695249796,
-0.004204922821372747,
0.005925737787038088,
-0.007530696224421263,
-0.0043923379853367805,
-0.03794652968645096,
-0.02499782294034958,
-0.055883899331092834,
-0.004116326104849577,
0.02976839989423752,
-0.0018008927581831813,
0.009425296448171139,
0.008607483468949795,
-0.03184019401669502,
0.020499849691987038,
0.009438927285373211,
0.015224955044686794,
0.028705241158604622,
-0.050540853291749954,
0.021890131756663322,
0.07709252089262009,
-0.026510776951909065,
-0.043562181293964386,
-0.027914689853787422,
-0.00781693123281002,
-0.027860168367624283,
-0.029414013028144836,
0.0008029051241464913,
0.029795659705996513,
-0.03260348364710808,
0.041163261979818344,
-0.06362586468458176,
-0.0037176422774791718,
0.016860581934452057,
0.01875518262386322,
-0.07453004270792007,
-0.03652898967266083,
-0.042989712208509445,
-0.02408459782600403,
0.01005910150706768,
-0.0047194636426866055,
-0.03598377853631973,
-0.043834786862134933,
0.006958227138966322,
-0.0010401561157777905,
0.015947356820106506,
0.009752421639859676,
-0.01542940828949213,
0.027260439470410347,
-0.019559364765882492,
0.05449361726641655,
-0.05931871384382248,
-0.03682885318994522,
0.01870066113770008,
-0.016097288578748703,
0.0686417818069458,
0.024793369695544243,
0.03920051082968712,
-0.005240819416940212,
0.018850592896342278,
-0.010215849615633488,
0.00757158687338233,
-0.00477398419752717,
0.020390808582305908,
0.009841018356382847,
-0.010495268739759922,
-0.05051359161734581,
-0.0007053638692013919,
-0.011497089639306068,
0.014529814012348652,
0.04209011793136597,
0.004099288489669561,
-0.007169495336711407,
0.04587931931018829,
-0.008109980262815952,
-0.03132224455475807,
0.012137710116803646,
-0.01880970224738121,
-0.07414839416742325,
-0.007646553218364716,
0.07234920561313629,
0.03715597838163376,
0.026156390085816383,
0.026210911571979523,
0.026047348976135254,
0.00375171797350049,
0.02272157557308674,
-0.02608823962509632,
-0.015524819493293762,
0.020786084234714508,
-0.03192197531461716,
0.0019474176224321127,
-0.02944127470254898,
0.01818271353840828,
-0.018060041591525078,
-0.017296748235821724,
-0.026347214356064796,
0.0035915628541260958,
0.0002366120897931978,
-0.00734668830409646,
0.020990537479519844,
0.0309133380651474,
-0.01722859777510166,
-0.04069983586668968,
0.036120083183050156,
0.001143234665505588,
0.015293106436729431,
-0.013459841720759869,
-0.009731976315379143,
-0.009309439919888973,
-0.08794217556715012,
0.004112918861210346,
0.02562481164932251,
0.013003229163587093,
-0.0059529985301196575,
-0.009813757613301277,
-0.007373948581516743,
0.012839666567742825,
0.015034131705760956,
0.02165841870009899,
0.00948663242161274,
-0.031949233263731,
-0.0248887799680233,
0.031049638986587524,
-0.017692023888230324,
-0.027887428179383278,
0.018741551786661148,
-0.05165852978825569,
0.039009686559438705,
0.01642441377043724,
0.00233758264221251,
0.0201727245002985,
-0.048496320843696594,
0.018032779917120934,
-0.036283645778894424,
-0.002063274383544922,
-0.036692552268505096,
-0.0369378961622715,
-0.022517122328281403,
0.01592009700834751,
0.004589976277202368,
0.0175557229667902,
-0.012819221243262291,
0.011905997060239315,
0.02273520641028881,
-0.01925949938595295,
-0.027642084285616875,
0.0019917157478630543,
-0.002030902775004506,
0.02602008916437626,
0.032085537910461426,
-0.030095525085926056,
-0.004358262754976749,
0.0111358892172575,
-0.05103154107928276,
0.03475705906748772,
-0.04091791808605194,
0.00043701889808289707,
0.006859407760202885,
-0.024534394964575768,
-0.03342129662632942,
-0.016042768955230713,
0.030558951199054718,
-0.01825086399912834,
0.04904152825474739,
-0.027682974934577942,
0.002502849092707038,
-0.02210821583867073,
0.05784665048122406,
0.0007219756953418255,
-0.023430347442626953,
-0.0332849957048893,
0.052885252982378006,
0.009731976315379143,
0.0017889662412926555,
0.04380752518773079,
0.0335303395986557,
-0.024752479046583176,
-0.04214463755488396,
0.017705654725432396,
-0.036965154111385345,
0.02562481164932251,
-0.030041003599762917,
-0.0218765027821064,
-0.06084530055522919,
-0.06924151629209518,
0.004572938662022352,
-0.013453026302158833,
-0.0218765027821064,
0.01039985753595829,
0.0030463540460914373,
0.050949759781360626,
-0.01932765170931816,
-0.0015572526026517153,
-0.04345313832163811,
0.01863251067698002,
-0.05212195962667465,
0.002450031926855445,
0.0025301093701273203,
-0.049695778638124466,
-0.006743551231920719,
0.05664719268679619,
0.0109995873644948,
-0.0555567741394043,
0.007210385985672474,
-0.01829175464808941,
0.020527109503746033,
0.004971622489392757,
-0.0051794834434986115,
-0.01653345674276352,
0.0027516004629433155,
-0.010004580952227116,
0.025938307866454124,
-0.005608835257589817,
-0.03295787051320076,
-0.005700839217752218,
0.018659770488739014,
0.04195381700992584,
-0.0004348891961853951,
0.027260439470410347,
-0.026101870462298393,
0.04127230495214462,
0.0016254036454483867,
0.011388048529624939,
0.02875976264476776,
-0.01579742506146431,
0.040209148079156876,
0.04279888793826103,
0.03835543617606163,
-0.002013864926993847,
0.035820215940475464,
-0.05266716703772545,
-0.024684326723217964,
-0.010890545323491096,
0.012403499335050583,
-0.030586212873458862,
0.01187192089855671,
-0.0505681149661541,
0.0017991889035329223,
-0.005240819416940212,
0.05392114818096161,
0.018509838730096817,
0.03652898967266083,
0.041844774037599564,
0.002441513119265437,
0.02829633466899395,
-0.0340755470097065,
0.020758824422955513,
0.02517501451075077,
-0.02028176560997963,
0.0031758411787450314,
-0.08003664761781693,
-0.005131777375936508,
-0.012478466145694256,
0.03197649493813515,
-0.021385814994573593,
0.034511715173721313,
-0.017692023888230324,
0.05942775681614876,
-0.020990537479519844,
0.09350330382585526,
0.04345313832163811,
0.02886880375444889,
0.00037674777559004724,
-0.04947769641876221,
-0.04312601312994957,
-0.0419265553355217,
-0.03950037434697151,
-0.05416649207472801,
0.02415274828672409,
-0.020240874961018562,
0.014175428077578545,
0.030368128791451454,
-0.016492566093802452,
-0.025079604238271713,
0.023730212822556496,
-0.020254505798220634,
0.04391656816005707,
-0.006453908979892731,
-0.04631548374891281,
0.05910063162446022,
-0.0009140765760093927,
0.07327605783939362,
0.003772163297981024,
-0.04170847311615944,
-0.005656540859490633,
-0.05937323719263077,
-0.04124504327774048,
-0.024902410805225372,
0.01692873239517212,
0.012989599257707596,
-0.03950037434697151,
-0.04165394976735115,
0.008920978754758835,
0.046506308019161224,
0.01022266410291195,
-0.027819277718663216,
0.004051582887768745,
0.02420726977288723,
-0.0036086004693061113,
0.01602913811802864,
-0.000118838477646932,
0.021290402859449387,
0.00963656511157751,
0.001528288354165852,
-0.03001374378800392,
-0.03726502135396004,
0.01664249785244465,
0.007598847150802612,
0.00792597234249115,
0.018441686406731606,
0.0012812406057491899,
0.0239755567163229,
0.019750187173485756,
-0.022421710193157196,
-0.015075022354722023,
0.0064607239328324795,
-0.04413465037941933,
-0.013037304393947124,
0.0408906564116478,
-0.055038824677467346,
-0.0033819982782006264,
0.025134123861789703,
0.02840537764132023,
-0.029686618596315384,
0.02272157557308674,
-0.022367190569639206,
0.003259326098486781,
0.032140057533979416,
-0.015224955044686794,
-0.015933725982904434,
-0.02307596057653427,
-0.012260382063686848,
-0.008082720451056957,
0.0031468768138438463,
-0.01864613965153694,
-0.00010563420073594898,
0.03421185165643692,
0.03107690066099167,
0.01574290357530117,
-0.00438893074169755,
0.008852827362716198,
0.008348509669303894,
0.0022898768074810505,
0.013684740290045738,
-0.01247165072709322,
0.02591104619204998,
0.010358966886997223,
0.0547662228345871,
-0.001952528953552246,
-0.0012795368675142527,
-0.032467182725667953,
0.019572995603084564,
-0.018537098541855812,
-0.0309133380651474,
-0.0014712117845192552,
-0.01601550728082657,
-0.0033019206020981073,
0.00030710588907822967,
0.005356676410883665,
0.0029577575623989105,
-0.015879206359386444,
0.015388517640531063,
-0.0030463540460914373,
0.024466244503855705,
0.019000526517629623,
0.011292636394500732,
0.00477398419752717,
0.07016836851835251,
0.0003959152672905475,
0.04865988343954086,
0.013255388475954533,
0.019981902092695236,
-0.06558861583471298,
0.017692023888230324,
-0.020949646830558777,
-0.004535455722361803,
-0.03914599120616913,
0.011183595284819603,
-0.014052756130695343,
-0.023089591413736343,
-0.01801915094256401,
-0.01437988132238388,
-0.05482074245810509,
-0.015320366248488426,
-0.016806060448288918,
-0.019750187173485756,
0.019763818010687828,
-0.02318500354886055,
-0.03606555983424187,
-0.020131833851337433,
-0.06727876514196396,
-0.03914599120616913,
0.02204006537795067,
-0.00023725100618321449,
-0.017010513693094254,
0.012587507255375385,
-0.04203559830784798,
0.00017804473463911563,
0.002732858993113041,
0.04056353121995926,
-0.024234529584646225,
-0.027533043175935745,
-0.027314959093928337,
-0.033721163868904114,
0.03181293234229088,
-0.013623404316604137,
-0.009357145987451077,
0.004579753614962101,
0.0029509426094591618,
-0.01173561904579401,
0.01692873239517212,
0.012914632447063923,
0.022639794275164604,
-0.013166791759431362,
-0.0016892952844500542,
0.011810584925115108,
0.010549790225923061,
0.027969209477305412,
-0.025324948132038116,
0.0005997296539135277,
0.005608835257589817,
-0.02955031581223011,
-0.017460310831665993,
0.0031741373240947723,
0.029850181192159653,
-0.03661077097058296,
-0.02670159935951233,
-0.0133576150983572,
-0.01762387342751026,
-0.014311729930341244,
-0.04069983586668968,
0.04454355686903,
-0.030667994171380997,
0.011660652235150337,
0.0037040121387690306,
-0.024220900610089302,
0.03808283433318138,
0.0033394037745893,
-0.014134537428617477,
0.05195839703083038,
-0.00977286696434021,
-0.015347626991569996,
-0.039636678993701935,
-0.010563420131802559,
-0.024016447365283966,
0.02302144095301628,
-0.05544773116707802,
0.02033628709614277,
-0.04410738870501518,
0.00920039787888527,
-0.037128716707229614,
0.030259087681770325,
0.03922777250409126,
-0.025270426645874977,
0.02483426034450531,
-0.011388048529624939,
-0.019504843279719353,
0.003683566814288497,
0.024820629507303238,
-0.0005784324603155255,
-0.04467985779047012,
-0.011953702196478844,
0.0029236820992082357,
-0.006470946595072746,
0.005993889179080725,
-0.013889193534851074,
-0.03437541425228119,
0.050377290695905685,
-0.024220900610089302,
0.01033852156251669,
-0.016260851174592972,
0.013446211814880371,
-0.0005860994569957256,
-0.011721989139914513,
-0.020867865532636642,
0.0288142841309309,
0.022489862516522408,
-0.001070824102498591,
-0.04530685022473335,
-0.042989712208509445,
0.038219135254621506,
-0.0408906564116478,
-0.010733798146247864,
0.009336700662970543,
0.022530753165483475,
0.018850592896342278,
0.003877797396853566,
-0.04127230495214462,
0.006505022291094065,
-0.018196342512965202,
0.035602133721113205,
0.009234474040567875,
0.018959635868668556,
-0.027015095576643944,
-0.03107690066099167,
0.03197649493813515,
0.0176783949136734,
-0.018605249002575874,
0.028105512261390686,
-0.027137767523527145,
-0.011783325113356113,
0.012083189561963081,
0.011319897137582302,
0.032358139753341675,
-0.009895538911223412,
-0.025502139702439308,
0.028378115966916084,
-0.012355794198811054,
0.008484811522066593,
0.01059749536216259,
-0.026837902143597603,
-0.027601193636655807,
-0.017283117398619652,
-0.04868714511394501,
0.014925090596079826,
-0.008382584899663925,
-0.0006150636472739279,
-0.031458545476198196,
-0.004293519072234631,
0.0038471294101327658,
0.0401001051068306,
0.07131330668926239,
-0.023607540875673294,
-0.0006163414800539613,
-0.004109511151909828,
-0.0021774275228381157,
0.006518652196973562,
-0.014870569109916687,
0.01699688285589218,
0.013568883761763573,
0.01269654929637909,
0.037810228765010834,
0.07562045753002167,
-0.00292708957567811,
-0.008259912952780724,
0.004065212793648243,
0.01256024744361639,
-0.00508747948333621,
-0.0072853523306548595,
-0.011428939178586006,
-0.02845989726483822,
0.030477169901132584,
-0.01170835830271244,
0.009043650701642036,
-0.03625638410449028,
-0.03658350929617882,
-0.014352620579302311,
0.007237646263092756,
-0.0002566314651630819,
-0.022748835384845734,
0.006171081680804491,
-0.016056397929787636,
0.01227401290088892,
-0.03197649493813515,
-0.02415274828672409,
0.010679276660084724,
-0.012621583417057991,
-0.020390808582305908,
-0.0036358609795570374,
-0.005554314237087965,
-0.0290868878364563,
-0.00026493737823329866,
0.037128716707229614,
0.0022677278611809015,
0.007755594793707132,
-0.010433932766318321,
-0.015933725982904434,
0.000709197367541492,
-0.028677981346845627,
0.006590211298316717,
0.011463014408946037,
-0.021740199998021126,
-0.004337817430496216,
-0.00043914862908422947,
-0.050322771072387695,
0.005138592794537544,
-0.02238081954419613,
0.009500263258814812,
-0.037537623196840286,
-0.00025897417799569666,
0.015824684873223305,
0.023144112899899483,
0.00007640376861672848,
0.037701185792684555,
-0.033557601273059845,
-0.019354911521077156,
0.037428583949804306,
0.0002608909271657467,
-0.04007284343242645,
0.04596110060811043,
-0.011415308341383934,
0.01988648995757103,
0.025556661188602448,
-0.022857878357172012,
-0.03652898967266083,
-0.04337135702371597,
0.008062275126576424,
0.029686618596315384,
-0.016792429611086845,
-0.012832851149141788,
-0.017991889268159866,
0.0036086004693061113,
0.04072709381580353,
-0.014965981245040894,
-0.050595372915267944,
0.012062744237482548,
-0.009936429560184479,
-0.005418012384325266,
0.030586212873458862,
0.008539332076907158,
-0.02580200508236885,
-0.002540332032367587,
-0.006341459695249796,
0.012287642806768417,
-0.01193325687199831,
-0.0030616880394518375,
-0.025815635919570923,
-0.04045449197292328,
0.019109567627310753,
0.02432994171977043,
-0.022694315761327744,
-0.02567933313548565,
-0.019504843279719353,
0.00026962277479469776,
0.023716581985354424,
-0.011599316261708736,
-0.006477761548012495,
0.025829264894127846,
0.015524819493293762,
0.010801948606967926,
0.009186767973005772,
0.020731564611196518,
-0.02393466606736183,
-0.00544186495244503,
-0.004058397840708494,
-0.010188588872551918,
0.006395980250090361,
0.031213201582431793,
-0.0054997936822474,
0.03813735395669937,
-0.01830538548529148,
0.033503077924251556,
-0.017760176211595535,
0.014897829852998257,
-0.0018963043112307787,
-0.0343208909034729,
-0.02352575957775116,
-0.030777035281062126,
0.012144525535404682,
0.027233177796006203,
0.01338487584143877,
0.006808294449001551,
-0.005043181125074625,
0.02408459782600403,
-0.030504431575536728,
0.031458545476198196,
0.036174602806568146,
-0.0062051573768258095,
0.0000947726221056655,
-0.08292625844478607,
0.0076397377997636795,
-0.02124951221048832,
-0.00881193671375513,
-0.033394038677215576,
0.05070441588759422,
-0.03268526494503021,
-0.04934139549732208,
0.013275833800435066,
-0.01409364677965641,
0.023253154009580612,
-0.04961399734020233,
0.023266784846782684,
-0.00502955075353384,
-0.008927793242037296,
-0.007960048504173756,
-0.009118616580963135,
-0.022530753165483475,
-0.0046683503314852715,
0.025093233212828636,
-0.013187237083911896,
-0.0006410462665371597,
-0.0034314077347517014,
0.012723810039460659,
-0.002628928516060114,
0.012744255363941193,
-0.007394393905997276,
-0.02540672942996025,
0.008832382038235664,
0.01469337660819292,
-0.00598025880753994,
0.019000526517629623,
-0.006041594780981541,
0.024697957560420036,
-0.013752891682088375,
-0.04209011793136597,
0.016056397929787636,
-0.002143352059647441,
-0.014870569109916687,
-0.0062085650861263275,
-0.014516184106469154,
-0.037701185792684555,
0.029114149510860443,
0.039691198617219925,
-0.008307619020342827,
0.006487984210252762,
-0.01761024259030819,
0.014134537428617477,
-0.0036426761653274298,
-0.006985487416386604,
-0.00012203305959701538,
-0.0176783949136734,
-0.013766521587967873,
-0.00792597234249115,
-0.02732858993113041,
-0.004181069787591696,
-0.02074519358575344,
0.021617528051137924,
0.030558951199054718,
-0.02306233160197735,
-0.01636989414691925,
0.0607907772064209,
0.021781090646982193,
-0.009561599232256413,
-0.0054895710200071335,
-0.0062562706880271435,
-0.008546147495508194,
0.04176299273967743,
-0.0639529898762703,
0.0009958578739315271,
-0.017419420182704926,
0.0018128191586583853,
-0.03453897684812546,
0.022980550304055214,
-0.03306691348552704,
-0.027124136686325073,
0.000836980645544827,
-0.0205680001527071,
-0.026606189087033272,
-0.028105512261390686,
0.012962338514626026,
-0.05959131941199303,
0.005220374092459679,
-0.0007292167283594608,
-0.001725074602290988,
0.0036290460266172886,
-0.03211279585957527,
-0.017569351941347122,
0.005625872872769833,
-0.02567933313548565,
0.03263074532151222,
-0.04683343321084976,
-0.0004020914784632623,
0.015197694301605225,
-0.015211325138807297,
-0.009881909005343914,
-0.031158681958913803,
0.013398505747318268,
0.024861520156264305,
-0.008116795681416988,
0.0032150279730558395,
-0.019695667549967766,
0.004964807536453009,
-0.03074977546930313,
-0.04274436831474304,
-0.00572469225153327,
0.04748768359422684,
-0.01151072047650814,
0.00849162694066763,
-0.012737439945340157,
0.03132224455475807,
0.03527500852942467,
0.01647893525660038,
0.03663802891969681,
-0.00935033056885004,
0.05522964894771576,
0.04348039999604225,
-0.04228094220161438,
0.028050990775227547,
0.002105868887156248,
0.041844774037599564,
0.040481749922037125,
0.006017741747200489,
-0.032985132187604904,
-0.016628867015242577,
0.022626163437962532,
0.006058632396161556,
0.020840605720877647,
-0.020199984312057495,
0.00493073184043169,
-0.030831556767225266,
0.012778330594301224,
-0.003799423575401306,
0.037019677460193634,
-0.03557487204670906,
0.027655715122818947,
0.0021109802182763815,
-0.0067196981981396675,
-0.015443038195371628,
0.008696080185472965,
0.0021501670125871897,
0.003424592548981309,
0.006419833283871412,
-0.043044231832027435,
0.043507661670446396,
0.012941893190145493,
-0.029059628024697304,
0.019000526517629623,
-0.006433463655412197,
0.01880970224738121,
-0.016110919415950775,
0.014679746702313423,
-0.013732446357607841,
0.05067715421319008,
0.01739216037094593,
0.03186745196580887,
-0.005458903033286333,
-0.044870682060718536,
-0.029632097110152245,
0.01511591300368309,
-0.010277185589075089,
0.06689711660146713,
-0.010127252899110317,
-0.06749684363603592,
0.04323505610227585,
-0.039118729531764984,
-0.012342163361608982,
-0.006706067826598883,
0.02352575957775116,
0.02687879279255867,
0.008477996103465557,
-0.07725608348846436,
0.052067436277866364,
-0.015620231628417969,
-0.005291932728141546,
0.0019576402846723795,
-0.0037789782509207726,
0.006297161336988211,
0.01846894808113575,
0.05234004184603691,
-0.020104574039578438,
-0.04203559830784798,
0.019859230145812035,
0.008409845642745495,
0.03710145875811577,
-0.018659770488739014,
-0.0202953964471817,
-0.0008041829569265246,
0.0447889007627964,
0.010120437480509281,
-0.018932374194264412,
0.0088391974568367,
-0.014311729930341244,
0.0385189987719059,
0.006041594780981541,
-0.021453965455293655,
-0.006866223178803921,
0.020881496369838715,
-0.020527109503746033,
0.0010767873609438539,
-0.02272157557308674,
-0.0026238171849399805,
0.03189471364021301,
-0.00004387226726976223,
-0.04018188640475273,
0.03767392784357071,
-0.004010692238807678,
-0.04931413382291794,
-0.025379467755556107,
0.040318187326192856,
0.009738791733980179,
0.03074977546930313,
0.0026783382054418325,
0.04209011793136597,
-0.0015427704202011228,
-0.04072709381580353,
-0.044298212975263596,
-0.006992302369326353,
-0.04301697388291359,
-0.027110505849123,
-0.008832382038235664,
-0.04018188640475273,
-0.007210385985672474,
-0.01846894808113575,
0.008920978754758835,
0.0003695067425724119,
0.023961925879120827,
0.030531691387295723,
-0.014597965404391289,
0.016615238040685654,
-0.04909605160355568,
0.0015589563408866525,
0.016110919415950775,
0.0001757020509103313,
0.0067674038000404835,
-0.01699688285589218,
-0.018836963921785355,
-0.004593383986502886,
-0.0263199545443058,
-0.0179509986191988,
0.024575285613536835,
0.024588916450738907,
-0.027192287147045135,
-0.007776040118187666,
-0.012096819467842579,
-0.016901472583413124,
0.04334409907460213,
0.032358139753341675,
-0.008893718011677265,
0.006631101947277784,
-0.01898689568042755,
0.017296748235821724,
0.021126840263605118,
0.03751036524772644,
0.04102696105837822,
0.029250450432300568,
-0.005199928767979145,
0.015824684873223305,
0.014461662620306015,
-0.006293753627687693,
-0.02085423655807972,
-0.019245870411396027,
-0.017078664153814316,
-0.004054990131407976,
0.023389456793665886,
-0.015783794224262238,
0.014107276685535908,
-0.008886902593076229,
0.01716044545173645,
0.03808283433318138,
0.0020087535958737135,
-0.006729920860379934,
-0.01440714206546545,
-0.00036758999340236187,
0.005653133615851402,
-0.010093177668750286,
0.03453897684812546,
0.003453556913882494,
-0.0002611038798931986,
0.027832908555865288,
-0.017146816477179527,
0.014911459758877754,
-0.018441686406731606,
0.002492626430466771,
0.0063039762899279594,
0.02295328862965107,
0.012389869429171085,
-0.01298278383910656,
-0.02063615247607231,
-0.017528461292386055,
-0.005421419627964497,
0.03751036524772644,
-0.014584334567189217,
0.015293106436729431,
0.0033308849669992924,
-0.02779201790690422,
-0.012887372635304928,
-0.002489218721166253,
-0.003502966370433569,
0.01761024259030819,
0.03652898967266083,
0.025652073323726654,
-0.0159746166318655,
-0.048387277871370316,
-0.008055459707975388,
-0.03205827623605728,
0.02745126187801361,
-0.012996413744986057,
0.006372127681970596,
-0.021971913054585457,
-0.042826149612665176,
0.014570704661309719,
0.03625638410449028,
0.00915269274264574,
0.03380294516682625,
0.012233122251927853,
-0.006027964409440756,
0.025420358404517174,
0.01653345674276352,
0.003117912681773305,
0.010052287019789219,
0.0014090238837525249,
-0.008566592819988728,
0.0069207437336444855,
-0.037537623196840286,
-0.02159026823937893,
-0.012226306833326817,
-0.016492566093802452,
0.009507077746093273,
0.006290346384048462,
-0.0024551432579755783,
-0.0016509603010490537,
0.024738848209381104,
-0.004794429522007704,
-0.009370775893330574,
0.016969623044133186,
0.02408459782600403,
0.013330354355275631,
0.01671064831316471,
0.010549790225923061,
-0.007946417666971684,
-0.033666640520095825,
0.0038403142243623734,
-0.013091825880110264,
0.012076374143362045,
0.005833733826875687,
0.023553019389510155,
0.013950529508292675,
0.00795323308557272,
0.015374887734651566,
0.06362586468458176,
-0.01116996444761753,
-0.025583921000361443,
0.018155451864004135,
0.022653425112366676,
-0.017419420182704926,
-0.0025215905625373125,
0.013514362275600433,
0.017637504264712334,
0.010127252899110317,
-0.01320768240839243,
0.01320768240839243,
0.000658084056340158,
-0.021154100075364113,
0.011776509694755077,
-0.009370775893330574,
-0.00410610344260931,
-0.010856470093131065,
-0.007673813495784998,
0.008505256846547127,
0.008075905032455921,
0.004041360225528479,
-0.025243166834115982,
-0.01703777350485325,
-0.009950060397386551,
0.005653133615851402,
0.012205861508846283,
0.021113209426403046,
0.016846951097249985,
0.030041003599762917,
-0.007510250899940729,
-0.005080664064735174,
-0.013596143573522568,
0.005462310276925564,
-0.0011091590858995914,
-0.0131599772721529,
-0.004041360225528479,
-0.02126314304769039,
0.029959222301840782,
-0.030558951199054718,
-0.013575698249042034,
-0.019245870411396027,
0.009084541350603104,
0.01511591300368309,
-0.02818729355931282,
0.000478335510706529,
0.005475940648466349,
0.02334856614470482,
-0.005547499284148216,
0.0037823859602212906,
-0.02510686405003071,
-0.0003117912565357983,
0.02368932217359543,
0.01630174182355404,
0.004491157364100218,
-0.011115443892776966,
-0.00524422712624073,
0.00906409602612257,
0.006474354304373264,
-0.027873799204826355,
-0.04437999427318573,
-0.009030020795762539,
-0.05915515124797821,
0.025270426645874977,
-0.031949233263731,
-0.019641146063804626,
0.005704246927052736,
-0.028432637453079224,
0.0004919657367281616,
-0.0017753361025825143,
0.007217200938612223,
0.025706592947244644,
-0.0066719925962388515,
-0.011524350382387638,
-0.004337817430496216,
-0.00830080360174179,
0.014897829852998257,
-0.0000130578564494499,
0.0027192288544028997,
0.0051283701322972775,
0.001834968337789178,
-0.035138703882694244,
-0.00623582536354661,
-0.0023307674564421177,
-0.021385814994573593,
0.00030455022351816297,
0.00954796839505434,
0.030613472685217857,
-0.021222252398729324,
0.007598847150802612,
0.00021212028514128178,
0.011660652235150337,
0.026388105005025864,
0.004368485417217016,
0.022980550304055214,
-0.007782855071127415,
0.004685387946665287,
-0.014025495387613773,
0.015293106436729431,
0.03238540142774582,
0.006126783788204193,
-0.0012914632679894567,
-0.009847833774983883,
-0.00036801592796109617,
0.0036869742907583714,
-0.0017046292778104544,
-0.030995119363069534,
-0.015865575522184372,
0.00326102995313704,
0.0070808990858495235,
-0.008334878832101822,
0.004736501257866621,
0.02591104619204998,
0.027969209477305412,
0.0006367868045344949,
0.012553432025015354,
0.0007492361473850906,
0.006194934714585543,
0.011013217270374298,
-0.002363139297813177,
-0.004988660104572773,
0.015252215787768364,
-0.004181069787591696,
-0.0071286046877503395,
0.009704716503620148,
-0.01187192089855671,
0.02818729355931282,
-0.0008318693144246936,
-0.017433051019906998,
-0.028841543942689896,
-0.024806998670101166,
0.024806998670101166,
-0.031785670667886734,
-0.022421710193157196,
0.00846436619758606,
0.02982291951775551,
-0.027546674013137817,
-0.025474879890680313,
-0.007367133628576994,
-0.013391690328717232,
-0.007142235059291124,
-0.00875060074031353,
-0.031104160472750664,
-0.029332231730222702,
-0.03840995952486992,
-0.006763996556401253,
0.0023921034298837185,
-0.02124951221048832,
0.005274895112961531,
0.003117912681773305,
-0.014311729930341244,
-0.012178600765764713,
0.005922330543398857,
-0.00866200402379036,
-0.010958696715533733,
-0.009527523070573807,
-0.049641259014606476,
-0.03950037434697151,
-0.003271252615377307,
-0.006065447814762592,
-0.0008791491272859275,
-0.03154032677412033,
-0.017065035179257393,
0.04623370245099068,
0.03233088180422783,
-0.0437530055642128,
-0.004784206859767437,
0.023334935307502747,
0.03317595273256302,
-0.010556604713201523,
-0.011251745745539665,
-0.021563006564974785,
0.01647893525660038,
-0.02528405748307705,
-0.014325360767543316,
-0.005973443854600191,
0.03715597838163376,
0.03148580715060234,
-0.035820215940475464,
0.0009541153558529913,
0.031785670667886734,
0.012546616606414318,
-0.02460254542529583,
0.0034893362317234278,
0.004940954502671957,
0.0429624505341053,
0.009929615072906017,
-0.010829209350049496,
-0.00598025880753994,
0.0035234116949141026,
-0.00988872442394495,
0.004313964396715164,
0.015811054036021233,
0.0025198867078870535,
0.017283117398619652,
0.009609304368495941,
0.037537623196840286,
-0.02063615247607231,
-0.012314903549849987,
0.004661534912884235,
0.01721496693789959,
-0.012205861508846283,
-0.02067704312503338,
-0.030558951199054718,
0.0026851531583815813,
-0.017460310831665993,
0.02393466606736183,
0.014911459758877754,
-0.02330767549574375,
0.010992771945893764,
-0.0023443978279829025,
-0.008798306807875633,
0.011033662594854832,
0.009609304368495941,
0.014938720501959324,
0.013016859069466591,
-0.020036421716213226,
0.01961388625204563,
-0.01778743602335453,
0.019927380606532097,
0.01042711827903986,
0.0029219782445579767,
0.013289463706314564,
-0.020431699231266975,
-0.00541119696572423,
0.028323596343398094,
-0.005462310276925564,
-0.02460254542529583,
-0.009493447840213776,
0.017801066860556602,
-0.045770276337862015,
-0.02114047110080719,
-0.02268068492412567,
0.001231831032782793,
-0.02773749642074108,
-0.01994101144373417,
-0.051222365349531174,
-0.0013246869202703238,
0.012069559656083584,
0.013378060422837734,
-0.02467069774866104,
-0.00022489861294161528,
-0.023662060499191284,
0.007367133628576994,
0.04102696105837822,
0.03164936974644661,
-0.025638442486524582,
0.005223781801760197,
-0.010386227630078793,
0.010474823415279388,
-0.03421185165643692,
0.03710145875811577,
-0.00037930344115011394,
-0.011974147520959377,
-0.0324944444000721,
-0.007626107893884182,
-0.023839253932237625,
-0.03184019401669502,
-0.010876915417611599,
-0.021917393431067467,
-0.014298100024461746,
0.014134537428617477,
0.010951881296932697,
-0.006194934714585543,
0.002903236774727702,
0.030259087681770325,
-0.023784732446074486,
-0.011742434464395046,
0.016492566093802452,
-0.006419833283871412,
0.007919157855212688,
0.02597919851541519,
0.007305797655135393,
0.03238540142774582,
-0.013970974832773209,
0.04260806739330292,
0.015770163387060165,
-0.018564358353614807,
0.047814808785915375,
-0.023103222250938416,
-0.004252628423273563,
0.007776040118187666,
0.01942306198179722,
-0.02840537764132023,
0.009977320209145546,
0.003262733807787299,
-0.015865575522184372,
0.0068764458410441875,
-0.03791927173733711,
0.01692873239517212,
0.0007577550131827593,
0.025188645347952843,
0.002477292437106371,
0.018741551786661148,
0.003928910940885544,
0.02824181504547596,
-0.031676631420850754,
-0.03647446632385254,
-0.0023324713110923767,
0.003502966370433569,
-0.0413813479244709,
0.0032422884833067656,
-0.018332645297050476,
-0.0035097815562039614,
0.01863251067698002,
0.019286761060357094,
-0.018537098541855812,
-0.010767873376607895,
-0.03445719555020332,
-0.005196521058678627,
0.024289051070809364,
0.0061063384637236595,
-0.02392103523015976,
0.006147229112684727,
-0.007714704144746065,
-0.01198777835816145,
-0.024275420233607292,
0.0481964573264122,
-0.033775683492422104,
0.028541678562760353,
-0.01994101144373417,
0.0218765027821064,
-0.03388472646474838,
-0.03598377853631973,
0.06684259325265884,
-0.03557487204670906,
-0.0060041118413209915,
0.005966628435999155,
0.014270839281380177,
-0.05506608635187149,
0.011374417692422867,
0.0061574517749249935,
0.026578927412629128,
-0.0205680001527071,
-0.02676975168287754,
0.028378115966916084,
0.012117264792323112,
0.00657998863607645,
0.017923738807439804,
-0.011537980288267136,
0.016001878306269646,
0.02307596057653427,
0.018209973350167274,
-0.004497972317039967,
-0.035765696316957474,
0.022762466222047806,
0.002603371860459447,
-0.010808764025568962,
-0.021045058965682983,
0.017596613615751266,
-0.027205917984247208,
-0.007810115814208984,
-0.0565926693379879,
0.02693331427872181,
0.007012747693806887,
-0.0029339047614485025,
0.037755709141492844,
-0.007278537377715111,
0.002954350085929036,
-0.01829175464808941,
-0.04064531251788139,
0.012737439945340157,
0.01942306198179722,
-0.010542974807322025,
0.01726948842406273,
-0.013630219735205173,
-0.028650721535086632,
-0.01244438998401165,
-0.0008297396125271916,
0.00035672838566824794,
-0.011905997060239315,
0.006944596767425537,
0.01676516979932785,
-0.0353567898273468,
-0.016628867015242577,
0.0007573290495201945,
0.01014769822359085,
0.004068620502948761,
-0.03276704624295235,
-0.0070263780653476715,
0.031349506229162216,
-0.010876915417611599,
0.009227658621966839,
0.010168143548071384,
-0.022857878357172012,
0.008334878832101822,
0.029577575623989105,
0.019368542358279228,
-0.005370306316763163
] | 2025-01-21 | 1 | 39836430 | [
"CAR+ T cells",
"T cell biology",
"Traditional piecewise models",
"plasma cells",
"traditional models",
"dose levels",
"baseline disease burden",
"encompassed baseline demographics",
"various covariates",
"dose level",
"a cell number-dependent expansion phase",
"maximum orva-cel transgene level",
"transgene kinetics",
"a cell number-dependent expansion rate",
"the cellular expansion phase",
"lag time",
"orva-cel expansion",
"a modified piecewise model",
"the modified piecewise model",
"B-cell maturation antigen",
"a bi-exponential contraction phase",
"Covariates",
"PK",
"bone marrow",
"ATA",
"EVOLVE",
"a modified model",
"Tmax",
"a CAR T-cell therapy",
"cellular physiology"
] | [] | 0 | 10.1158/1078-0432.CCR-24-2753 | [
"Hu",
"Li",
"Piasecki",
"Hosseyni",
"Yan",
"Liu",
"Ogasawara",
"Zhou",
"Cheng"
] | [
"Bristol-Myers Squibb (United States), Princeton, New Jersey, United States.",
"Bristol-Myers Squibb (United States), Princeton, NJ, United States.",
"Bristol-Myers Squibb (United States), United States.",
"Bristol-Myers Squibb (United States), Boudry, Switzerland.",
"Bristol-Myers Squibb (United States), United States.",
"Bristol-Myers Squibb (United States), United States.",
"Bristol-Myers Squibb (United States), Summit, United States.",
"Aurinia Pharmaceuticals, United States.",
"Bristol-Myers Squibb (United States), Summit, New Jersey, United States."
] | [
"39836430"
] | [] | 5.44703 | 5.483919 |
39835140 | 10 | Advances in CAR T cell therapy: antigen selection, modifications, and current trials for solid tumors. | Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematologic malignancies, achieving remarkable clinical success with FDA-approved therapies targeting CD19 and BCMA. However, the extension of these successes to solid tumors remains limited due to several intrinsic challenges, including antigen heterogeneity and immunosuppressive tumor microenvironments. In this review, we provide a comprehensive overview of recent advances in CAR T cell therapy aimed at overcoming these obstacles. We discuss the importance of antigen identification by emphasizing the identification of tumor-specific and tumor-associated antigens and the development of CAR T therapies targeting these antigens. Furthermore, we highlight key structural innovations, including cytokine-armored CARs, protease-regulated CARs, and CARs engineered with chemokine receptors, to enhance tumor infiltration and activity within the immunosuppressive microenvironment. Additionally, novel manufacturing approaches, such as the Sleeping Beauty transposon system, mRNA-based CAR transfection, and | [
0.030550353229045868,
0.0016721346182748675,
0.04794958978891373,
0.05689777061343193,
-0.0392499715089798,
-0.037238892167806625,
-0.006163171958178282,
0.019082672894001007,
0.007445518393069506,
0.012292449362576008,
-0.004392178263515234,
-0.01094796322286129,
-0.04826594144105911,
0.011976099573075771,
0.014484302140772343,
-0.02239304594695568,
0.04275241494178772,
0.008242041803896427,
0.04587072134017944,
0.012744377367198467,
0.018901901319622993,
-0.008202498778700829,
0.001151710981503129,
-0.0008565453463234007,
-0.03509223088622093,
-0.0004914720193482935,
-0.003344269236549735,
0.01867593638598919,
-0.04132884368300438,
-0.028087344020605087,
0.015478543937206268,
-0.01292514894157648,
-0.006795871537178755,
-0.027341661974787712,
-0.013218902051448822,
0.04727169871330261,
-0.0071913087740540504,
-0.011987397447228432,
-0.005942856892943382,
-0.003496795194223523,
0.05210733041167259,
0.026595979928970337,
0.03007582761347294,
0.07547202706336975,
-0.06534883379936218,
0.012021292932331562,
-0.0207322109490633,
-0.0468197725713253,
-0.009061162360012531,
-0.003070287872105837,
-0.03952112793922424,
0.008677023462951183,
-0.02066442184150219,
0.02239304594695568,
-0.06308919191360474,
0.03443693742156029,
-0.03294557332992554,
0.01846127025783062,
-0.00456730043515563,
0.013535251840949059,
0.005903313402086496,
-0.029058989137411118,
0.003149375319480896,
-0.008756110444664955,
-0.06806039810180664,
0.014111461117863655,
-0.06593633443117142,
-0.04672938585281372,
0.01212297659367323,
0.02720608375966549,
0.024087777361273766,
-0.010089298710227013,
0.002407930325716734,
0.004081477411091328,
0.05499967187643051,
-0.015964366495609283,
-0.03443693742156029,
0.0535535030066967,
-0.007089625112712383,
0.003234111936762929,
0.015263877809047699,
-0.011264313012361526,
0.007586746010929346,
-0.06950657069683075,
-0.016461487859487534,
-0.00703878328204155,
0.010467789135873318,
-0.03258403018116951,
-0.045463986694812775,
-0.005318630952388048,
-0.0012413904769346118,
0.017907658591866493,
-0.04767843335866928,
0.045599564909935,
-0.0030985332559794188,
-0.0012696360936388373,
-0.02239304594695568,
-0.06358630955219269,
0.044514935463666916,
0.028946006670594215,
0.0612814761698246,
0.010789788328111172,
-0.025918086990714073,
-0.0029347094241529703,
0.046910155564546585,
-0.026437804102897644,
-0.04433416575193405,
-0.016743943095207214,
0.011128733865916729,
-0.0227997824549675,
0.037623029202222824,
-0.030369581654667854,
0.009428353980183601,
0.05947376415133476,
-0.04087691381573677,
-0.031341228634119034,
0.0004137968353461474,
0.0038555131759494543,
0.006767625920474529,
0.025149809196591377,
-0.023138727992773056,
0.031024876981973648,
0.03497925028204918,
-0.03192873299121857,
0.020698316395282745,
-0.03192873299121857,
0.08053362369537354,
-0.024675285443663597,
-0.05748527869582176,
-0.06611710786819458,
0.009337968192994595,
0.018755024299025536,
0.01573840342462063,
-0.004626615904271603,
-0.06765366345643997,
-0.004801738075911999,
-0.026144051924347878,
0.0010401412146165967,
-0.011614557355642319,
-0.006705486215651035,
0.002040738705545664,
-0.015128299593925476,
-0.015523736365139484,
-0.01359174307435751,
-0.018257902935147285,
-0.06611710786819458,
0.008151656948029995,
0.03683215752243996,
-0.013840303756296635,
0.040153827518224716,
-0.026844540610909462,
0.04263943433761597,
0.05974492058157921,
-0.00876740925014019,
0.0008537207613699138,
-0.061100706458091736,
-0.0082815857604146,
0.056626614183187485,
-0.022946659475564957,
-0.052378490567207336,
-0.0088747413828969,
0.008891688659787178,
-0.025014230981469154,
-0.0465938076376915,
0.02336469292640686,
-0.018427375704050064,
-0.006117979064583778,
0.020461052656173706,
-0.05151982605457306,
-0.01458598580211401,
-0.046413034200668335,
-0.0662526860833168,
-0.08053362369537354,
-0.009337968192994595,
-0.03400760516524315,
0.020935578271746635,
0.018992286175489426,
0.027590222656726837,
-0.03403019905090332,
-0.02824551798403263,
0.0185516569763422,
0.02526279166340828,
0.0296464953571558,
-0.016099944710731506,
-0.01414535567164421,
0.025511352345347404,
-0.016438892111182213,
0.012710482813417912,
-0.030505159869790077,
-0.027590222656726837,
-0.004078652709722519,
0.01313981506973505,
0.0672469288110733,
0.017286257818341255,
0.003796197706833482,
-0.01720716990530491,
0.020438456907868385,
0.03299076482653618,
-0.03199652209877968,
-0.02232525683939457,
0.022765887901186943,
-0.04408560320734978,
-0.019658880308270454,
0.01969277486205101,
-0.047904398292303085,
-0.025104615837335587,
-0.03224508464336395,
0.038707658648490906,
-0.017907658591866493,
0.006987940985709429,
0.03369125351309776,
-0.01576099917292595,
-0.0007513308082707226,
0.008400216698646545,
-0.029058989137411118,
-0.02206539921462536,
-0.00507007073611021,
0.056219879537820816,
0.010207930579781532,
0.03253883868455887,
-0.01458598580211401,
-0.008580988273024559,
-0.00791439414024353,
0.007908744737505913,
-0.02194111794233322,
0.021263226866722107,
0.010066702961921692,
-0.039656706154346466,
0.007281694561243057,
-0.017026398330926895,
0.00036260182969272137,
0.009524389170110226,
0.011286908760666847,
-0.008230743929743767,
-0.05640064924955368,
-0.03981488198041916,
0.03346528857946396,
0.0038300922606140375,
0.04616447538137436,
-0.027002714574337006,
0.01292514894157648,
0.01919565349817276,
0.038617271929979324,
-0.019839651882648468,
-0.005993698723614216,
-0.0010055404854938388,
-0.01387419831007719,
-0.07465855032205582,
0.0148232476785779,
-0.0056293318048119545,
0.006598153151571751,
0.008349374867975712,
-0.0164501890540123,
0.025443563237786293,
0.03730668127536774,
0.015286474488675594,
0.03875285014510155,
-0.03547637164592743,
0.01571580581367016,
-0.02865225449204445,
-0.015817489475011826,
0.011704943142831326,
-0.052378490567207336,
-0.05635545775294304,
-0.061597827821969986,
0.010885822586715221,
0.003866811515763402,
0.010445192456245422,
0.05206213891506195,
-0.005132210440933704,
0.03493405506014824,
0.02431374229490757,
0.04263943433761597,
-0.002659315476194024,
-0.05703334882855415,
0.0103096142411232,
-0.008891688659787178,
0.05201694741845131,
0.012371537275612354,
0.015241282060742378,
0.004592721350491047,
0.01706029288470745,
0.010744594968855381,
-0.01675524190068245,
-0.0074624656699597836,
-0.011236066929996014,
0.008146007545292377,
-0.017760781571269035,
0.00755285145714879,
-0.02969168871641159,
0.017918957397341728,
0.013038131408393383,
-0.04121585935354233,
-0.026189245283603668,
-0.0036323736421763897,
-0.00631004897877574,
-0.010038456879556179,
-0.011897012591362,
-0.014924931339919567,
0.01573840342462063,
-0.047452472150325775,
0.010874524712562561,
-0.004510809201747179,
-0.038165345788002014,
0.031296033412218094,
0.020980771631002426,
-0.01876632310450077,
-0.03396240994334221,
0.035770125687122345,
0.03409798815846443,
0.02521759830415249,
-0.01777208037674427,
0.022833677008748055,
0.02237045019865036,
0.00030099129071459174,
0.031860943883657455,
0.004685931373387575,
-0.0707719698548317,
0.01684562675654888,
-0.05676219239830971,
-0.026415208354592323,
-0.005914611276239157,
-0.04286539927124977,
0.023997392505407333,
0.015433351509273052,
-0.04971211031079292,
0.009128951467573643,
-0.03854948282241821,
0.03145420923829079,
-0.050796739757061005,
0.004779141861945391,
-0.05264964699745178,
0.05676219239830971,
-0.016913415864109993,
0.0030250949785113335,
-0.0013105920515954494,
-0.016122542321681976,
-0.04817555472254753,
0.037193696945905685,
0.006281803362071514,
-0.004937316756695509,
0.039091795682907104,
-0.04424377903342247,
0.051339052617549896,
0.01758000999689102,
-0.009072460234165192,
0.015953069552779198,
0.023003149777650833,
-0.014134056866168976,
0.023138727992773056,
0.006168821360915899,
0.013015534728765488,
0.02822292223572731,
-0.0009892992675304413,
-0.0074172732420265675,
0.03595089539885521,
-0.03608647361397743,
-0.005530472379177809,
0.01040564849972725,
-0.025149809196591377,
0.025918086990714073,
0.00479891337454319,
-0.04033460095524788,
0.033307116478681564,
0.05147463083267212,
0.05549679324030876,
-0.007372080348432064,
0.04672938585281372,
-0.021737750619649887,
-0.05016404017806053,
-0.015376860275864601,
-0.007688430137932301,
0.01796414889395237,
-0.005767734721302986,
-0.02625703439116478,
0.041667789220809937,
0.03163497895002365,
0.0057027703151106834,
0.0076093426905572414,
-0.008072569034993649,
0.02621184103190899,
-0.014710266143083572,
-0.007575448136776686,
-0.027816185727715492,
-0.0014151004143059254,
0.021523084491491318,
0.026528190821409225,
-0.01385160256177187,
-0.0732123851776123,
0.017116783186793327,
-0.01387419831007719,
-0.004143617581576109,
0.00799913052469492,
0.010767191648483276,
-0.031860943883657455,
0.07163063436746597,
-0.014778055250644684,
0.062049753963947296,
0.05499967187643051,
0.01168234646320343,
0.009462248533964157,
-0.03656099736690521,
-0.0012781097320839763,
-0.029307549819350243,
0.01606605015695095,
-0.019591091200709343,
0.03972449526190758,
0.026166647672653198,
0.005222596228122711,
-0.02438153140246868,
-0.008829548954963684,
0.008016077801585197,
0.037668224424123764,
0.020076913759112358,
-0.021172840148210526,
-0.012676588259637356,
-0.04528321325778961,
0.04137403517961502,
-0.018845409154891968,
0.03364606201648712,
0.0533275380730629,
-0.02829071134328842,
0.02435893565416336,
-0.02213318832218647,
-0.011388593353331089,
0.011258663609623909,
0.024991635233163834,
0.01573840342462063,
-0.0047395979054272175,
-0.040131233632564545,
-0.031815752387046814,
0.03448212891817093,
0.011761433444917202,
-0.0063213468529284,
-0.00890863686800003,
0.04286539927124977,
-0.022754589095711708,
0.02682194486260414,
-0.02044975571334362,
0.02388441003859043,
-0.05915741249918938,
-0.006564258597791195,
0.012699184939265251,
-0.019568495452404022,
0.014495600014925003,
0.014066267758607864,
0.0016636609798297286,
0.03168017417192459,
-0.020043019205331802,
-0.014021075330674648,
-0.0321321003139019,
-0.042006734758615494,
0.0025562194641679525,
0.012846061959862709,
-0.032855186611413956,
0.010157088749110699,
0.03448212891817093,
-0.07411623746156693,
0.0015520912129431963,
0.03509223088622093,
0.03990526869893074,
-0.04230048879981041,
0.019319934770464897,
-0.044221181422472,
-0.011897012591362,
0.04826594144105911,
0.04417598992586136,
-0.02090168371796608,
0.021997610107064247,
-0.02957870624959469,
0.01917305774986744,
-0.00315502448938787,
-0.018111025914549828,
0.0019093970768153667,
-0.021003367379307747,
0.02204280160367489,
0.01066550798714161,
0.014054969884455204,
0.024675285443663597,
0.0021438347175717354,
-0.02340988628566265,
0.004239652305841446,
-0.023952199146151543,
0.004200108349323273,
0.025466158986091614,
0.0041068983264267445,
-0.041532211005687714,
0.001752634416334331,
-0.028607061132788658,
0.046864964067935944,
-0.023206517100334167,
0.010258772410452366,
-0.008620532229542732,
-0.008976425975561142,
-0.02040456235408783,
-0.03007582761347294,
-0.020393263548612595,
-0.021975012496113777,
-0.047000542283058167,
0.02087908610701561,
-0.007264747284352779,
0.012823465280234814,
0.018404779955744743,
0.037668224424123764,
0.03830092400312424,
0.042006734758615494,
0.012394133023917675,
0.07009407877922058,
0.016642259433865547,
0.04173557832837105,
-0.02908158488571644,
-0.011360347270965576,
0.034278761595487595,
-0.00034018195583485067,
-0.022765887901186943,
-0.00443737069144845,
-0.053734272718429565,
-0.008247691206634045,
0.00006236080662347376,
-0.0040108636021614075,
0.002667789114639163,
-0.003609777195379138,
0.004058880731463432,
0.007936990819871426,
0.02431374229490757,
-0.022731993347406387,
-0.02327430620789528,
-0.030889298766851425,
-0.03364606201648712,
-0.02383921667933464,
0.017354046925902367,
-0.018427375704050064,
-0.007292992901057005,
0.0018105377675965428,
-0.013953286223113537,
-0.013659532181918621,
-0.0424586646258831,
0.04286539927124977,
-0.011394241824746132,
-0.02829071134328842,
-0.0037481803447008133,
-0.010953611694276333,
0.017094187438488007,
0.000627050525508821,
-0.01576099917292595,
0.020585333928465843,
-0.02028028294444084,
-0.0062705050222575665,
0.014891036786139011,
-0.009349266067147255,
0.013716023415327072,
-0.02232525683939457,
0.0126426937058568,
-0.006134926341474056,
0.02204280160367489,
-0.035227809101343155,
-0.032267678529024124,
-0.03509223088622093,
-0.0056519280187785625,
-0.039679303765296936,
-0.011140032671391964,
-0.02632482349872589,
0.01803193800151348,
-0.01285735983401537,
-0.016879521310329437,
0.039611514657735825,
0.0020986420568078756,
-0.015252579934895039,
-0.029510917142033577,
0.005044649355113506,
0.0038413903675973415,
0.0033951113000512123,
0.006920151878148317,
-0.04614187777042389,
0.036628786474466324,
0.005632156506180763,
-0.010772841051220894,
0.01118522509932518,
0.014450406655669212,
0.025036826729774475,
-0.02253992296755314,
-0.026482997462153435,
-0.018348287791013718,
0.048808254301548004,
0.006123628467321396,
0.019986528903245926,
-0.04517023265361786,
-0.010789788328111172,
-0.01621292717754841,
0.005262140184640884,
0.03070852719247341,
0.008761759847402573,
0.028313307091593742,
0.021760346367955208,
-0.051384247839450836,
0.014393916353583336,
0.011580662801861763,
-0.004942965693771839,
-0.012755676172673702,
-0.0049881585873663425,
0.005993698723614216,
-0.022144487127661705,
-0.004846930969506502,
-0.04966691881418228,
-0.041035089641809464,
0.03782639652490616,
-0.008462357334792614,
-0.03486626595258713,
0.01381770707666874,
-0.005824225954711437,
0.03692254051566124,
0.03628984093666077,
-0.031883541494607925,
0.0041294945403933525,
-0.0016382400644943118,
0.024630092084407806,
-0.03660619258880615,
-0.007586746010929346,
0.00021625474619213492,
-0.017907658591866493,
-0.014857142232358456,
-0.0037199347279965878,
-0.024471916258335114,
-0.007140466943383217,
-0.0011248777154833078,
-0.032358065247535706,
-0.013094622641801834,
0.004019337240606546,
0.012145573273301125,
0.012518413364887238,
-0.013829005882143974,
-0.04867267608642578,
-0.01895839162170887,
0.03540858253836632,
0.007558500859886408,
-0.04817555472254753,
0.025692123919725418,
-0.027002714574337006,
0.004762194585055113,
0.012043888680636883,
-0.008665724657475948,
0.005183052737265825,
-0.001195491524413228,
-0.01921825110912323,
0.023500271141529083,
-0.017500923946499825,
-0.01236023847013712,
0.017128081992268562,
-0.0011397066991776228,
-0.021997610107064247,
-0.0011502987472340465,
-0.021692557260394096,
0.024019988253712654,
-0.0364932082593441,
0.00848495401442051,
-0.021127646788954735,
0.007276045624166727,
0.0011036936193704605,
0.05784682184457779,
0.09463378041982651,
-0.02580510452389717,
0.02168126031756401,
-0.001528082531876862,
-0.009450950659811497,
-0.014879738911986351,
-0.002426289953291416,
0.021500488743185997,
-0.015862682834267616,
0.015727104619145393,
0.008146007545292377,
0.07447778433561325,
0.02912677824497223,
0.008948179893195629,
-0.014518196694552898,
0.0006778924143873155,
0.023613253608345985,
0.011704943142831326,
-0.027047907933592796,
-0.029782073572278023,
-0.0049344920553267,
-0.019252145662903786,
0.022426940500736237,
-0.029827266931533813,
-0.05459293723106384,
-0.009693861939013004,
-0.00879000499844551,
0.0163711030036211,
0.01796414889395237,
0.0062309615314006805,
-0.007061379496008158,
0.005976751446723938,
-0.014337425120174885,
-0.047362085431814194,
-0.013286692090332508,
0.028448885306715965,
0.01770429126918316,
0.006660293322056532,
-0.016913415864109993,
-0.022280065342783928,
-0.01632590964436531,
0.02483345940709114,
0.01852905936539173,
0.027590222656726837,
-0.03457251563668251,
0.024946441873908043,
-0.018709830939769745,
0.0007061379728838801,
-0.008942531421780586,
0.0017851167358458042,
0.03154459595680237,
0.005098315887153149,
-0.0014673547120764852,
-0.029759477823972702,
-0.013772514648735523,
0.02090168371796608,
-0.004815860651433468,
0.004773492459207773,
0.04178076982498169,
0.006084084510803223,
0.023477675393223763,
0.004457142669707537,
0.021760346367955208,
-0.01067680586129427,
0.018167518079280853,
0.03314894065260887,
0.01722976565361023,
-0.033804237842559814,
0.04876306280493736,
-0.021263226866722107,
-0.0040108636021614075,
-0.004044758155941963,
-0.03018881008028984,
-0.035815317183732986,
-0.0033555675763636827,
-0.010416947305202484,
0.014348722994327545,
-0.01997523009777069,
-0.020223790779709816,
-0.012992938049137592,
-0.008439760655164719,
0.017636502161622047,
-0.02777099423110485,
-0.028358500450849533,
-0.0010274307569488883,
-0.01734274812042713,
0.026550786569714546,
0.016981204971671104,
-0.007795763202011585,
0.012337642721831799,
-0.017173275351524353,
0.007603693287819624,
0.006886257324367762,
-0.0017159152776002884,
-0.02028028294444084,
0.009095056913793087,
-0.022359151393175125,
0.0049344920553267,
0.0015789244789630175,
-0.02677675150334835,
-0.03057294897735119,
-0.03396240994334221,
-0.005931559018790722,
0.005971102509647608,
0.003996741026639938,
-0.00545138493180275,
0.015399456955492496,
0.025533948093652725,
0.01559152640402317,
-0.00646257447078824,
0.013004236854612827,
-0.011450733058154583,
-0.02429114654660225,
0.0008650189847685397,
-0.02729646861553192,
-0.023138727992773056,
0.020348072052001953,
-0.017839869484305382,
0.0209242794662714,
-0.031386420130729675,
0.009756001643836498,
0.0014715915312990546,
0.02122933231294155,
-0.008083866909146309,
0.01947810873389244,
-0.001285877195186913,
-0.00492884311825037,
-0.005098315887153149,
0.01898098737001419,
-0.0271608904004097,
-0.010134492069482803,
-0.020607929676771164,
0.032380662858486176,
-0.03158978745341301,
0.025624334812164307,
-0.010648560710251331,
0.03009842336177826,
0.051881369203329086,
-0.06241129711270332,
-0.02630222588777542,
0.0067337313666939735,
-0.011433785781264305,
-0.007100923452526331,
0.007716675754636526,
-0.033826831728219986,
-0.009637370705604553,
0.028087344020605087,
-0.004770668223500252,
0.013783812522888184,
-0.015648016706109047,
0.0057027703151106834,
0.007699728477746248,
-0.0011940792901441455,
-0.021556979045271873,
-0.031296033412218094,
-0.04616447538137436,
-0.0177494827657938,
0.04272982105612755,
0.005632156506180763,
-0.005044649355113506,
-0.01032091211527586,
0.05436697229743004,
0.004807387012988329,
0.010925366543233395,
-0.011354697868227959,
-0.01560282427817583,
-0.04813036322593689,
-0.027951763942837715,
0.0020548615138977766,
0.026166647672653198,
-0.037623029202222824,
0.03635763004422188,
-0.007637588307261467,
-0.05093231797218323,
0.026189245283603668,
-0.014902335591614246,
-0.012834763154387474,
-0.002131124259904027,
-0.0008784356177784503,
0.004222705028951168,
0.021025963127613068,
0.0023923953995108604,
-0.01917305774986744,
-0.027974361553788185,
-0.021556979045271873,
-0.017659097909927368,
0.004443020094186068,
-0.009970667771995068,
0.0069992393255233765,
-0.025059424340724945,
-0.049350570887327194,
-0.0060784355737268925,
0.0092758284881711,
-0.02677675150334835,
-0.00945659913122654,
0.03513742610812187,
0.01824660412967205,
0.015659315511584282,
-0.03418837487697601,
0.06173340603709221,
0.052333295345306396,
-0.010394350625574589,
0.004832807928323746,
-0.021624768152832985,
-0.032267678529024124,
0.03308115154504776,
-0.03127343952655792,
0.025533948093652725,
-0.01458598580211401,
0.0056519280187785625,
-0.041102878749370575,
0.018811514601111412,
0.0018119500018656254,
0.018133623525500298,
-0.013659532181918621,
-0.00877870712429285,
0.0024771320167928934,
0.0034770232159644365,
-0.02308223769068718,
-0.011281260289251804,
-0.001405920716933906,
0.010699402540922165,
-0.04241346940398216,
-0.012800868600606918,
-0.014156653545796871,
0.01571580581367016,
0.0184386745095253,
-0.006372188683599234,
-0.004615317564457655,
-0.019681477919220924,
0.0013812058605253696,
-0.009157196618616581,
-0.0017893535550683737,
-0.019466811791062355,
0.0014970124466344714,
0.0020859315991401672,
0.006106681190431118,
-0.018303096294403076,
0.050796739757061005,
-0.02230266109108925,
-0.006010646466165781,
-0.04426637664437294,
-0.04632265120744705,
-0.03208690881729126,
0.033849429339170456,
-0.007869201712310314,
0.004022161941975355,
0.007502009626477957,
0.033849429339170456,
-0.0003175855381414294,
0.03398500755429268,
-0.034233566373586655,
-0.0065190657041966915,
0.0051887016743421555,
0.035679738968610764,
-0.0022878870368003845,
0.0031719717662781477,
-0.008360673673450947,
0.06439977884292603,
0.009530037641525269,
-0.0037566539831459522,
-0.02109375223517418,
-0.009281476959586143,
-0.005473981611430645,
0.013117218390107155,
0.041125472635030746,
0.005801629275083542,
0.0005935089429840446,
0.020314177498221397,
0.01805453561246395,
-0.007163063623011112,
-0.0009780010441318154,
0.007259098347276449,
0.04948614910244942,
0.0032708309590816498,
0.03127343952655792,
-0.006434328854084015,
0.01964758336544037,
0.005403367802500725,
-0.012258554808795452,
-0.00609538285061717,
-0.01680043339729309,
0.044447146356105804,
-0.01760260760784149,
-0.0563102662563324,
0.025985876098275185,
0.009682564064860344,
0.006417381577193737,
-0.026098858565092087,
0.03201911970973015,
0.05965453386306763,
0.0674728974699974,
0.0066376966424286366,
0.008473655208945274,
0.009976317174732685,
-0.006253557745367289,
-0.022020205855369568,
0.03195133060216904,
-0.03608647361397743,
0.042955782264471054,
-0.025624334812164307,
-0.018303096294403076,
-0.008456707932054996,
0.008242041803896427,
-0.01895839162170887,
-0.0007372079999186099,
0.03206431120634079,
0.00646257447078824,
0.013693427667021751,
-0.04921499267220497,
0.047000542283058167,
0.0026197717525064945,
-0.02770320512354374,
0.021624768152832985,
0.02779358997941017,
0.014642477035522461,
0.027545029297471046,
0.04051537066698074,
-0.044537533074617386,
-0.009490493685007095,
0.02107115648686886,
0.039204780012369156,
0.00799913052469492,
-0.007953938096761703,
-0.004581423010677099,
-0.023974794894456863,
0.003228462766855955,
0.011851819232106209,
-0.02474307455122471,
-0.04033460095524788,
0.019037479534745216,
0.05002846196293831,
0.008066919632256031,
-0.022901466116309166,
-0.02763541415333748,
0.010524280369281769,
-0.0317479632794857,
-0.02220097742974758,
-0.05197175219655037,
0.02535317651927471,
0.024517109617590904,
-0.01068810373544693,
-0.03658359497785568,
-0.0004141499230172485,
0.007846605032682419,
-0.040673546493053436,
-0.005440086591988802,
0.03267441689968109,
0.000568794144783169,
0.0378715917468071,
-0.028019554913043976,
0.0231048334389925,
0.014947528019547462,
0.008513199165463448,
0.0060049970634281635,
0.003525040578097105,
-0.029397934675216675,
-0.0032058663200587034,
-0.05061597004532814,
-0.0418485589325428,
-0.011795327998697758,
-0.022731993347406387,
-0.008258989080786705,
0.007739271968603134,
0.04776882007718086,
0.017161976546049118,
-0.00609538285061717,
-0.00015482075104955584,
-0.010123193264007568,
0.016856925562024117,
0.028064746409654617,
0.0185516569763422,
-0.0024008690379559994,
0.0007336773560382426,
-0.028855621814727783,
-0.026505595073103905,
0.02182813733816147,
-0.018992286175489426,
0.06394785642623901,
0.029420532286167145,
0.005166105460375547,
-0.0394759364426136,
-0.01067680586129427,
0.010439543053507805,
0.054638128727674484,
-0.03009842336177826,
-0.011275610886514187,
-0.019229548051953316,
-0.012224660255014896,
0.011603258550167084,
0.028358500450849533,
0.037690818309783936,
0.04975730553269386,
0.023500271141529083,
0.013625637628138065,
0.014789353124797344,
0.027319064363837242,
0.005942856892943382,
0.0009398696129210293,
-0.0037679520901292562,
0.006225312128663063,
-0.010416947305202484,
0.032764799892902374,
-0.015681911259889603,
0.00822509452700615,
-0.018642041832208633,
0.0018825638107955456,
0.03495665267109871,
0.017738185822963715,
0.009100706316530704,
-0.005344051867723465,
0.0035448125563561916,
0.008004779927432537,
-0.024584898725152016,
0.008518848568201065,
-0.009524389170110226,
-0.008134709671139717,
0.0034318305552005768,
0.003912004176527262,
0.014902335591614246,
-0.02481086365878582,
0.008942531421780586,
0.01359174307435751,
0.00667724059894681,
-0.024200759828090668,
0.0031296033412218094,
-0.0005825638072565198,
-0.03224508464336395,
-0.021263226866722107,
-0.005685823038220406,
-0.012032590806484222,
-0.007959586568176746,
-0.003700162982568145,
-0.013275393284857273,
0.005869418848305941,
-0.014450406655669212,
0.014156653545796871,
-0.016551872715353966,
0.012902552261948586,
0.02573731541633606,
-0.0019870721735060215,
-0.019037479534745216,
0.02820032462477684,
-0.007824008353054523,
-0.031838346272706985,
-0.05165540426969528,
0.06720173358917236,
-0.0005038294475525618,
-0.04654861241579056,
0.02085649035871029,
0.01798674650490284,
-0.007869201712310314,
0.024471916258335114,
0.021771645173430443,
-0.02625703439116478,
0.0009045627084560692,
0.010846278630197048,
0.02185073308646679,
-0.025398369878530502,
0.01094796322286129,
0.014213144779205322,
-0.027341661974787712,
-0.031386420130729675,
-0.002052036812528968,
0.012461923062801361,
-0.0020548615138977766,
-0.025985876098275185,
-0.040583159774541855,
0.019071374088525772,
-0.01649538241326809,
0.020325474441051483,
1.3515921182261081e-7,
0.015885278582572937,
0.0030505158938467503,
0.00006990765541559085,
0.004279195796698332,
0.01554633304476738,
0.001309179817326367,
-0.013941987417638302,
0.010287017561495304,
0.004044758155941963,
0.029895056039094925,
0.017591308802366257,
-0.012891254387795925,
-0.015580227598547935,
-0.014258337207138538,
-0.03195133060216904,
-0.011784030124545097,
0.04704573377966881,
-0.028923410922288895,
-0.03906920179724693,
0.04519283026456833,
-0.003313199384137988,
-0.02869744598865509,
-0.0027228679973632097,
0.0000028493768695625477,
0.0028146659024059772,
0.002585877198725939,
0.008213796652853489,
0.040696144104003906,
0.03007582761347294,
-0.018517762422561646,
-0.002355676144361496,
0.017128081992268562,
-0.010230526328086853,
-0.0012491580564528704,
-0.008999021723866463,
-0.0030279194470494986,
0.010343508794903755,
0.03113785944879055,
-0.027025312185287476,
-0.00988028198480606,
0.0010782727040350437,
0.016924714669585228,
0.058208364993333817,
0.027386855334043503,
-0.0016580119263380766,
0.043000977486371994,
0.00003510829628794454,
-0.003064638702198863,
-0.019116567447781563,
-0.0061970665119588375,
-0.010642911307513714,
-0.00957523100078106,
-0.03323932737112045,
-0.0317479632794857,
0.013060727156698704,
0.00042791961459442973,
0.010823682881891727,
-0.011784030124545097,
0.014755458571016788,
-0.01169364433735609,
-0.034278761595487595,
-0.0029460075311362743,
-0.007626289967447519,
0.005392069462686777,
-0.031815752387046814,
0.010270070284605026,
-0.053282346576452255,
-0.039588917046785355,
0.02524019591510296,
-0.014439108781516552,
-0.0009441064321435988,
0.02133101597428322,
0.003880934091284871,
0.031815752387046814,
0.009151548147201538,
0.004185985773801804,
-0.006852362770587206,
-0.000618223799392581,
-0.06033242493867874,
0.03633503615856171,
-0.01976056396961212,
-0.00879000499844551,
0.012473220936954021,
-0.03014361672103405,
-0.04853709787130356,
-0.006841064430773258,
-0.007518956903368235,
-0.004911895841360092,
0.0024743073154240847,
0.0070557305589318275,
0.010942313820123672,
0.0012018467532470822,
0.020845191553235054,
0.009411406703293324,
-0.035679738968610764,
0.013964584097266197,
-0.0001403449132340029,
0.007129168603569269,
0.004050407093018293,
-0.008677023462951183,
-0.03940814733505249,
0.018608147278428078,
-0.001116404077038169,
0.005999348126351833,
-0.01190831046551466,
0.016687452793121338,
0.006694187875837088,
0.0031013579573482275,
0.043543290346860886,
0.012574904598295689,
0.009919825941324234,
-0.028471482917666435,
-0.02923976071178913,
-0.01054687611758709,
0.0021000541746616364,
0.03357827290892601,
0.01673264428973198,
0.02232525683939457,
-0.05301119014620781,
-0.017670396715402603,
-0.02135361172258854,
0.002982726786285639,
-0.03454991802573204,
-0.010863225907087326,
0.005835523828864098,
0.007812710478901863,
-0.025488754734396935,
-0.011382943950593472,
-0.0035363389179110527,
0.01580619253218174,
-0.0013127104612067342,
-0.011580662801861763,
-0.020675718784332275,
-0.014247039332985878,
-0.017591308802366257,
-0.01680043339729309,
0.01781727373600006,
0.003996741026639938,
0.022268766537308693,
-0.007677131798118353,
0.010558174923062325,
-0.037645626813173294,
0.04609668627381325,
0.016054753214120865,
0.016676153987646103,
-0.033307116478681564,
-0.03685475140810013,
0.013670830987393856,
0.01437131967395544,
-0.018562953919172287,
0.005177403334528208,
0.03023400343954563,
-0.011829222552478313,
-0.011004453524947166,
0.04381444677710533,
0.0053497012704610825,
-0.008925584144890308,
-0.020156001672148705,
-0.011987397447228432,
0.016393698751926422,
-0.013467462733387947,
0.00595980416983366,
0.014529494568705559,
-0.0021593698766082525,
-0.013783812522888184,
-0.020777402445673943,
-0.021059857681393623,
0.0026692014653235674,
-0.004301792476326227,
-0.03344269469380379,
0.011659749783575535,
0.0031973926816135645,
-0.04523802176117897,
-0.0712238997220993,
0.017003802582621574,
0.006665942259132862,
-0.03267441689968109,
0.008541444316506386,
-0.013941987417638302,
0.0007329711806960404,
0.04410820081830025,
-0.0325162410736084,
0.007801412139087915,
0.04044758155941963,
0.030346984043717384,
0.02047235146164894,
0.012574904598295689,
0.006739380769431591,
0.029985442757606506,
-0.0026579033583402634,
-0.00016338267596438527,
-0.02025768533349037,
-0.001662248745560646,
0.02208799496293068,
-0.022765887901186943,
0.02336469292640686,
0.05111309140920639,
-0.014902335591614246,
0.017873764038085938,
-0.0018769146408885717,
-0.012281151488423347,
0.04315915331244469,
-0.0045560020953416824,
-0.0075359041802585125,
-0.00864877738058567,
-0.014924931339919567,
-0.013094622641801834,
0.012168169021606445,
0.026482997462153435,
-0.0013889733236283064,
-0.006400434300303459,
0.008168604224920273,
0.025963280349969864,
-0.024449320510029793,
-0.024675285443663597,
0.0252853874117136,
0.036244649440050125,
-0.0026579033583402634,
0.011727538891136646,
-0.010885822586715221,
-0.01191960833966732,
-0.03782639652490616,
0.0018853882793337107,
0.0037453556433320045,
-0.009970667771995068,
0.02144399657845497,
-0.0007252036593854427,
-0.0031634981278330088,
0.02438153140246868,
0.004039109218865633,
0.008304182440042496,
-0.0006987234810367227,
-0.0172523632645607,
0.003948723431676626,
-0.016246821731328964,
-0.007072677835822105,
-0.014631178230047226,
-0.013422270305454731,
-0.023613253608345985,
0.005081368610262871,
-0.041487015783786774,
0.01902618072926998,
-0.002892340999096632,
0.005465507972985506,
0.001262574689462781,
-0.008671374060213566,
-0.027047907933592796,
0.009032916277647018,
-0.01891319826245308,
0.021692557260394096,
-0.013749917969107628,
-0.01722976565361023,
-0.03604128211736679,
0.0004452199791558087,
0.0037481803447008133,
0.018190113827586174,
-0.06697577238082886,
0.00456730043515563,
0.007349483668804169,
-0.003242585575208068,
0.007970885373651981,
0.044469743967056274,
-0.004519282840192318,
0.004406300839036703,
-0.035815317183732986,
-0.007976534776389599,
0.010541227646172047,
0.03448212891817093,
-0.012518413364887238,
-0.02571471966803074,
-0.01431482844054699,
-0.00014661189925391227,
-0.005742313805967569,
-0.02578250877559185,
-0.03547637164592743,
0.029420532286167145,
-0.039114393293857574,
-0.012653992511332035,
-0.0009921238524839282,
0.002785008167847991,
-0.016054753214120865,
0.027838783338665962,
-0.05509005859494209,
0.0031267788726836443,
-0.013185007497668266,
0.007761868182569742,
0.02623443678021431,
0.03879804536700249,
-0.010569472797214985,
0.012710482813417912,
-0.009366214275360107,
0.01768169365823269,
-0.018517762422561646,
-0.0009561107726767659,
0.020325474441051483,
-0.00618011923506856,
-0.023093536496162415,
0.015173492021858692,
0.02208799496293068,
-0.041667789220809937,
0.008857794106006622,
-0.004050407093018293,
-0.0006902498425915837,
0.019726669415831566,
-0.05689777061343193,
0.019726669415831566,
0.015128299593925476,
0.020540140569210052,
0.0010867463424801826,
0.01904877834022045,
-0.04912460595369339,
0.016879521310329437,
-0.02064182423055172,
-0.011055295355618,
-0.004022161941975355,
-0.012518413364887238,
-0.03007582761347294,
0.007496360689401627,
0.014167952351272106,
0.0136369364336133,
0.04907941073179245,
0.019817056134343147,
-0.011286908760666847,
0.018495164811611176,
-0.014416512101888657,
-0.0010323736350983381,
0.01889060251414776,
-0.005482455249875784,
0.00003098180241067894,
0.011625855229794979,
0.025443563237786293,
0.0010196631774306297,
0.02921716310083866,
0.014066267758607864,
-0.016359804198145866,
0.009671265259385109,
-0.010620314627885818,
0.004530581180006266,
-0.03158978745341301,
0.003047691425308585,
0.10792047530412674,
-0.028109939768910408,
-0.011942205019295216,
0.02481086365878582,
0.0069992393255233765,
-0.01919565349817276,
0.009140249341726303,
-0.004524931777268648,
0.03545377403497696,
-0.017410537227988243,
0.01155241671949625,
-0.0035419880878180265,
0.03371385112404823,
0.027025312185287476,
0.051293861120939255,
-0.01585138402879238,
0.017421836033463478,
0.04365627467632294,
0.001213144976645708,
-0.0030505158938467503,
0.009558283723890781,
0.01729755476117134,
0.00012842884461861104,
0.024404127150774002,
-0.02768060751259327,
0.0023076587822288275,
-0.0022271592170000076,
-0.0044514937326312065,
0.0015167843084782362,
-0.008394568227231503,
0.00951309036463499,
0.0014334600418806076,
0.018382182344794273,
-0.009112004190683365,
-0.004510809201747179,
-0.049350570887327194,
-0.021172840148210526,
-0.02481086365878582,
-0.008315480314195156,
0.0003262357204221189,
0.002390983048826456,
0.003149375319480896,
-0.004491037223488092,
0.013218902051448822,
0.018099727109074593,
0.020574035122990608,
-0.008501901291310787,
0.0061970665119588375,
-0.007146115880459547,
-0.017613904550671577,
-0.00836632214486599,
-0.01671004854142666,
0.0026098857633769512,
-0.02064182423055172,
-0.028448885306715965,
-0.009253231808543205,
0.00740032596513629,
0.0016481259372085333,
0.0025039652828127146,
-0.02327430620789528,
-0.010467789135873318,
0.012541010044515133,
0.028064746409654617,
-0.006790222600102425,
-0.003143726149573922
] | 2025-01-21 | 74 | 39835140 | [
"CAR T therapies",
"CAR T cell therapy",
"T cell therapy",
"immunosuppressive tumor microenvironments",
"antigen identification",
"tumor infiltration",
"solid tumors",
"Chimeric antigen receptor",
"antigen heterogeneity",
"CAR",
"CARs",
"remarkable clinical success",
"several intrinsic challenges",
"key structural innovations",
"chemokine receptors",
"recent advances",
"hematologic malignancies",
"cytokine-armored CARs",
"FDA-approved therapies",
"protease-regulated CARs",
"the Sleeping Beauty transposon system",
"mRNA-based CAR transfection",
"tumor-specific and tumor-associated antigens",
"FDA",
"activity",
"CD19",
"these antigens",
"BCMA",
"a comprehensive overview",
"the immunosuppressive microenvironment"
] | [
"CAR T cell",
"cancer",
"immunotherapy",
"solid tumors",
"structure",
"targets"
] | 0 | 10.3389/fimmu.2024.1489827
10.1158/2159-8290.CD-12-0548
10.1159/000496870
10.3390/ijms21020515
10.1056/NEJMoa1709866
10.1016/S1470-2045(18)30864-7
10.1056/NEJMoa1914347
10.1016/S0140-6736(20)31366-0
10.1056/NEJMoa2024850
10.1016/S0140-6736(21)00933-8
10.1038/s41591-022-02182-7
10.1182/blood.V96.5.1999
10.1158/1078-0432.CCR-06-1183
10.1038/sj.mt.6300104
10.1186/s40364-017-0102-y
10.1038/s43018-021-00244-2
10.1073/pnas.2221116120
10.1016/j.bbcan.2022.188701
10.1016/j.ymthe.2019.10.010
10.1126/science.aba7365
10.1038/s41586-018-0178-z
10.1080/21645515.2022.2114254
10.1182/bloodadvances.2022009019
10.1172/JCI46110
10.1038/mt.2009.210
10.1016/j.immuni.2016.01.021
10.1016/j.ymthe.2018.01.020
10.1038/leu.2014.215
10.1158/1078-0432.CCR-16-1300
10.3389/fimmu.2021.755639
10.1016/j.cell.2022.03.041
10.1158/0008-5472.CAN-11-0103
10.4049/jimmunol.1800033
10.1038/nm.4478
10.1126/scitranslmed.abb6295
10.1016/j.ccell.2022.08.008
10.1038/nm.1882
10.1056/NEJMoa0911123
10.1016/j.ccell.2019.01.002
10.1182/blood-2019-123424
10.1158/2326-6066.CIR-15-0231
10.1038/s41467-020-16160-5
10.1093/neuonc/nox182
10.1158/1078-0432.CCR-19-1479
10.1016/j.cell.2016.01.011
10.1073/pnas.2312374120
10.1016/j.omtm.2018.12.009
10.1002/med.21818
10.7150/thno.34941
10.1038/nm.3838
10.1146/annurev-biochem-063011-092449
10.1038/s41467-019-10097-0
10.1038/s41591-023-02452-y
10.1111/j.1744-9987.1997.tb00137.x
10.1038/cgt.2015.5
10.4049/jimmunol.159.12.5921
10.3389/fimmu.2021.640082
10.1186/s13045-018-0677-2
10.1038/s41573-019-0051-2
10.1016/j.cell.2024.06.027
10.1038/s41551-019-0409-0
10.1002/jgm.v15.2
10.1089/hum.2013.075
10.1158/2326-6066.CIR-13-0170
10.1158/0008-5472.CAN-10-2880
10.1038/s41578-021-00358-0
10.1038/natrevmats.2017.56
10.1038/s41565-019-0591-y
10.1182/blood-2010-01-043737
10.3791/50070-v
10.1093/hmg/ddr140
10.1016/j.omtm.2019.03.003
10.1016/j.omtm.2018.10.006
10.3389/fmed.2023.1141880
10.15252/emmm.201809158
10.1016/j.ymthe.2020.05.005
10.1038/s41408-021-00508-1
10.1016/j.jconrel.2020.01.035
10.1038/s41467-020-19486-2
10.1038/s41467-017-01830-8
10.1016/j.ymthe.2021.06.004
10.1021/bc2006219
10.1126/science.abm0594
10.1002/smll.202304378
10.1097/CJI.0b013e31824e801f
10.1038/mtm.2014.15
10.1038/cgt.2014.78
10.1038/s41409-022-01866-5
10.3389/fimmu.2020.01941
10.1038/s41551-021-00842-6
10.1158/2326-6066.CIR-17-0405
10.1080/2162402X.2017.1284722
10.1002/btm2.10097
10.1172/jci.insight.133977
10.1172/JCI83092
10.1172/JCI121491
10.1038/s41467-023-40115-1
10.1016/j.celrep.2018.04.051
10.1016/j.celrep.2017.11.063
10.1073/pnas.1610544113
10.1158/1078-0432.CCR-18-1811
10.1186/2162-3619-1-36
10.1056/NEJMoa1707447
10.1016/S1470-2045(21)00591-X
10.1056/NEJMoa2116133
10.1016/S0140-6736(21)01222-8
10.1056/NEJMoa1804980
10.1038/s41591-021-01622-0
10.1016/S0140-6736(22)00662-6
10.1056/NEJMoa1215134
10.1186/s13045-020-01001-1
10.1016/S0140-6736(14)60493-1
10.1111/ejh.2018.101.issue-2
10.3389/fimmu.2019.01613
10.3389/fonc.2022.1070353
10.1186/s13287-020-02128-1
10.1200/JCO.22.00842
10.1038/s41408-021-00459-7
10.1186/s13045-021-01115-0
10.3389/fonc.2021.794183
10.1038/srep03571
10.1038/s41568-020-00323-z
10.1038/icb.2013.17
10.1146/annurev-immunol-032712-095951
10.1007/s00280-018-3670-0
10.1158/1078-0432.CCR-16-1421
10.1016/j.pharmthera.2015.07.007
10.1158/1078-0432.CCR-16-0492
10.1016/j.ccell.2018.07.001
10.1038/nbt.4239
10.1126/scitranslmed.aau5516
10.1093/bioadv/vbac032
10.1016/j.jcyt.2020.04.088
10.1007/s00432-021-03613-7
10.1126/scitranslmed.aaa0984
10.1007/s13238-017-0440-4
10.1186/s40364-019-0169-8
10.1158/2159-8290.CD-21-0407
10.1002/j.1460-2075.1986.tb04629.x
10.1128/jcm.26.3.595-597.1988
10.3389/fmed.2023.1121020
10.1172/jci.insight.126345
10.1200/JCO.2018.36.5_suppl.TPS79
10.1158/1538-7445.AM2023-1791
10.3390/biomedicines9081054
10.21037/tcr-19-1876
10.1038/s41591-022-01800-8
10.3389/fonc.2020.01000
10.1016/j.ccell.2023.11.011
10.3390/ijms22126567
10.1186/s12943-023-01751-9
10.3389/fimmu.2021.701006
10.1186/gb-2008-9-5-224
10.1038/s41591-024-02979-8
10.1038/s41591-022-01726-1
10.1200/JCO.2022.40.6_suppl.098
10.1080/14728222.2021.1937124
10.1038/bjc.2011.451
10.1038/s41467-024-45221-2
10.1038/s41467-023-37874-2
10.1200/JCO.19.00646
10.1200/JCO.2022.40.16_suppl.TPS5101
10.1097/PPO.0000000000000029
10.1126/sciadv.adg9721
10.1182/blood.2020008221
10.1186/bcr1305
10.1126/scitranslmed.abk1900
10.1097/CCM.0000000000002053
10.2147/ITT.S202015
10.1182/blood-2017-06-793141
10.1038/s41409-020-01134-4
10.1158/2159-8290.CD-17-1368
10.1158/2159-8290.CD-17-0698
10.1186/s40425-018-0343-9
10.1038/leu.2016.262
10.1038/s41409-021-01420-9
10.1016/j.heliyon.2023.e20460
10.1002/ptr.v37.12
10.1182/blood.2023021672
10.1038/mt.2013.185
10.1007/s10875-012-9689-9
10.1038/s41587-019-0192-1
10.1038/s41467-023-43416-7
10.1186/s13045-016-0378-7
10.1016/j.xcrm.2022.100543
10.1097/CJI.0b013e3181ee6675
10.1158/1078-0432.CCR-11-0351
10.1089/10430340260355374
10.1038/s41467-019-11869-4
10.1158/2326-6066.CIR-13-0027
10.1038/nm.3833
10.1038/s41573-021-00189-2
10.1182/blood-2011-12-400044
10.1016/j.celrep.2017.09.002
10.1158/2326-6066.CIR-18-0572
10.3389/fcell.2018.00038
10.1182/blood-2018-10-881722
10.1038/s41586-022-05126-w
10.1038/s41586-019-1821-z
10.1126/scitranslmed.abh0272
10.1038/s41586-024-07018-7
10.1038/s41586-019-1805-z
10.1038/s41591-024-02826-w
10.1021/acs.nanolett.3c01720 | [
"Khan",
"Choi",
"Veena",
"Lee",
"Shin"
] | [
"Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, United States.\nDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA, United States.",
"Division of Hematology/Oncology, Veterans Affairs (VA) Greater Los Angeles Healthcare System, Los Angeles, CA, United States.",
"Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, United States.\nDivision of Hematology/Oncology, Veterans Affairs (VA) Greater Los Angeles Healthcare System, Los Angeles, CA, United States.",
"Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, United States.\nDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, United States.",
"Department of Medicine, Division of Hematology/Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, United States.\nDivision of Hematology/Oncology, Veterans Affairs (VA) Greater Los Angeles Healthcare System, Los Angeles, CA, United States."
] | [
"39835140",
"31947597",
"30518502",
"10961908",
"28652918",
"37192158",
"35202772",
"31672285",
"32029687",
"34737753",
"35483375",
"33408186",
"36084652",
"30753824",
"27059623",
"32385241",
"37963244",
"31064990",
"25675873",
"33746981",
"30482221",
"39013470",
"23322669",
"30417026",
"30224381",
"34162832",
"33247092",
"29170511",
"26015959",
"32849651",
"28405515",
"30065964",
"31999649",
"37550294",
"23210908",
"34895487",
"30501490",
"33272302",
"31379824",
"36505779",
"33494834",
"33824268",
"34193217",
"35145905",
"24389689",
"26213107",
"30078747",
"30518613",
"28724573",
"31463062",
"31415244",
"34440262",
"32733795",
"38134936",
"34207342",
"36859240",
"34349762",
"18505598",
"38336975",
"37041154",
"23833565",
"38039357",
"37018415",
"31754614",
"29907163",
"37790973",
"37980341",
"28057014",
"35492880",
"31488817",
"29670880",
"30463995",
"34788079",
"31802004"
] | [] | 8.945672 | 4.319164 |
39833408 | 11 | Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies. | Long-term risks of gene therapy are not fully understood. In this study, we evaluated safety outcomes in 783 patients over more than 2,200 total patient-years of observation from 38 T cell therapy trials. The trials employed integrating gammaretroviral or lentiviral vectors to deliver engineered receptors to target HIV-1 infection or cancer. Eighteen patients (2.3%) developed secondary malignancies after treatment, with a median onset of 1.94 years (range: 51 d to 14 years). Where possible, incident tumor samples were analyzed for vector copy number, revealing no evidence of high-level marking or other indications of insertional mutagenesis. One T cell lymphoma was detected, but malignant T cells were not marked by vector integration. Analysis of vector integration sites in 176 patients revealed no pathological insertions linked to secondary malignancies, although, in some cases, integration in or near specific genes, including tumor suppressor genes, was associated with modest clonal expansion and sustained T cell persistence. These findings highlight the safety of engineered T cell therapies. | [
-0.00005343982047634199,
0.025706466287374496,
0.07187555730342865,
0.019798407331109047,
-0.0575190931558609,
-0.01465944480150938,
0.046145785599946976,
0.010714911855757236,
0.016174331307411194,
0.012049177661538124,
-0.0057390909641981125,
-0.039293836802244186,
-0.02041601575911045,
0.007341375108808279,
-0.021604618057608604,
-0.054116424173116684,
0.022560162469744682,
-0.030693940818309784,
-0.005718698259443045,
0.02698829397559166,
0.03053079918026924,
0.048103488981723785,
-0.019693531095981598,
0.020462626591324806,
0.005031172651797533,
-0.03234866261482239,
0.02491406351327896,
-0.0027602987829595804,
-0.00459418585523963,
-0.01855153776705265,
0.012713397853076458,
-0.022268837317824364,
0.0004945232067257166,
0.013202822767198086,
-0.01307463925331831,
0.04824332147836685,
0.11280081421136856,
-0.01620929129421711,
0.0026583352591842413,
-0.0004362582985777408,
0.021336600184440613,
-0.0009810349438339472,
-0.00383965577930212,
0.0913127213716507,
-0.042859647423028946,
-0.023830337449908257,
-0.012713397853076458,
-0.06381169706583023,
-0.017584342509508133,
0.009211678057909012,
0.006630543619394302,
-0.02022956684231758,
-0.054302871227264404,
0.04264989495277405,
-0.029202358797192574,
0.03952689468860626,
-0.032278746366500854,
0.0031666962895542383,
-0.033980078995227814,
-0.029202358797192574,
0.002276700222864747,
-0.006665502674877644,
0.03591447323560715,
-0.03740605339407921,
-0.028176898136734962,
-0.014939116314053535,
-0.0575190931558609,
-0.0006420061690732837,
-0.007387987338006496,
0.013808777555823326,
-0.015253745950758457,
-0.04094855859875679,
0.031439729034900665,
-0.014985728077590466,
0.005852707661688328,
0.058031823486089706,
0.015032339841127396,
0.005264231935143471,
-0.022443633526563644,
-0.02398182637989521,
0.07224845141172409,
-0.010423587635159492,
-0.0134475352242589,
0.012189013883471489,
-0.016815245151519775,
-0.008605723269283772,
0.01826021447777748,
-0.028992606326937675,
-0.02999476157128811,
0.010254619643092155,
-0.017642606049776077,
0.035285212099552155,
-0.00823865458369255,
0.042952872812747955,
-0.014344814233481884,
0.0015090605011209846,
0.04017946496605873,
-0.05998952314257622,
0.0172580573707819,
-0.005150615703314543,
0.019786754623055458,
0.03754588961601257,
0.008815476670861244,
-0.007976462133228779,
0.022816527634859085,
-0.03111344762146473,
-0.02847987413406372,
0.008728079497814178,
0.0354483537375927,
0.015207134187221527,
0.0382450707256794,
0.013167863711714745,
0.001447882386855781,
0.05761231482028961,
-0.03400338441133499,
-0.022082390263676643,
-0.055235110223293304,
-0.0019489603582769632,
0.047450918704271317,
0.03206899017095566,
-0.022828180342912674,
0.026219196617603302,
0.01481093280017376,
-0.027780696749687195,
0.009677796624600887,
-0.02315446361899376,
0.04968829080462456,
-0.009194198064506054,
-0.00833187811076641,
-0.05388336256146431,
0.026102667674422264,
-0.012352155521512032,
0.03055410459637642,
0.014403078705072403,
-0.06823983043432236,
-0.034236446022987366,
0.030204515904188156,
0.045120324939489365,
-0.024797534570097923,
-0.015428541228175163,
-0.02528695948421955,
-0.007213192526251078,
-0.0006037698476575315,
-0.005567209329456091,
-0.006036242004483938,
-0.007114142179489136,
0.03251180425286293,
0.033700406551361084,
0.03213891014456749,
0.0040435828268527985,
-0.020194608718156815,
0.06530328094959259,
0.019821712747216225,
0.007271457463502884,
-0.0354483537375927,
-0.05630718171596527,
-0.024890758097171783,
0.07635030150413513,
-0.02971509099006653,
-0.016442349180579185,
-0.01428654883056879,
0.04064558073878288,
0.0005356727633625269,
-0.018038807436823845,
-0.01817864365875721,
-0.0009038340067490935,
0.006560625974088907,
0.016081107780337334,
-0.04320923611521721,
-0.03146303817629814,
0.03561149537563324,
-0.02042766846716404,
-0.05984968692064285,
-0.016908468678593636,
-0.048103488981723785,
-0.03446950390934944,
-0.003257006872445345,
0.018947739154100418,
-0.011891862377524376,
-0.040342606604099274,
-0.026731928810477257,
0.013599023222923279,
0.05239178240299225,
0.01405349001288414,
-0.05169260501861572,
0.007690964732319117,
-0.002840413013473153,
0.03241858258843422,
-0.02952864207327366,
-0.05453592911362648,
0.024983981624245644,
-0.022373715415596962,
0.045866116881370544,
-0.01950708217918873,
0.015393582172691822,
-0.013051333837211132,
0.03197576850652695,
0.047567449510097504,
0.010825615376234055,
-0.03745266795158386,
0.03279147669672966,
-0.031136753037571907,
-0.051972273737192154,
-0.016756979748606682,
-0.04523685574531555,
-0.0579385980963707,
-0.010808135382831097,
0.055141884833574295,
-0.009817632846534252,
0.040249381214380264,
0.030600717291235924,
0.010988757014274597,
-0.02605605497956276,
0.007085009943693876,
-0.017071610316634178,
-0.017864013090729713,
-0.026825152337551117,
0.04153120890259743,
0.016430696472525597,
-0.006985959596931934,
-0.005564296152442694,
0.012585214339196682,
-0.01537027582526207,
0.009019403718411922,
0.029365500435233116,
0.012154054827988148,
-0.003679427318274975,
-0.021779412403702736,
-0.009013577364385128,
-0.019705183804035187,
-0.007399640046060085,
0.023772072046995163,
-0.003766824724152684,
-0.07574434578418732,
-0.0219192486256361,
0.003513372503221035,
0.031905848532915115,
0.02913244068622589,
0.024121660739183426,
0.002493737032637,
0.03512207046151161,
0.0013779645087197423,
0.023387523368000984,
0.027897225692868233,
-0.01602284237742424,
-0.010557596571743488,
-0.0012293889885768294,
-0.042416833341121674,
0.03192915394902229,
0.004463090095669031,
-0.04479404166340828,
0.020649073645472527,
0.0004901533247902989,
-0.008652335032820702,
0.015533417463302612,
0.007865759544074535,
0.013692247681319714,
-0.008349358104169369,
0.03015790320932865,
-0.0007017276948317885,
0.06572278589010239,
-0.039596814662218094,
-0.04796365275979042,
0.0030589064117521048,
-0.05253161862492561,
0.030996916815638542,
0.023585624992847443,
0.02913244068622589,
0.005954671185463667,
-0.025147123262286186,
0.04805687442421913,
-0.02210569567978382,
0.012189013883471489,
-0.03074055165052414,
-0.04038921743631363,
-0.005657520145177841,
0.029388807713985443,
0.024517862126231194,
-0.027850614860653877,
0.02640564553439617,
-0.04160112515091896,
0.0268950704485178,
-0.02247859165072441,
-0.0006055906414985657,
-0.009800152853131294,
-0.004174679052084684,
-0.001387432566843927,
0.02250189706683159,
-0.020765604451298714,
-0.05141293257474899,
0.01855153776705265,
0.043139319866895676,
0.03169609606266022,
-0.0378255620598793,
0.01594127155840397,
0.04316262528300285,
0.005424460396170616,
0.019169146195054054,
-0.06707452982664108,
0.006315913517028093,
-0.036124225705862045,
-0.012608520686626434,
-0.0018134944839403033,
-0.01808542013168335,
0.0008237197762355208,
0.029924843460321426,
-0.035658109933137894,
0.0068869092501699924,
-0.029761701822280884,
0.06716775894165039,
0.038641270250082016,
-0.04950184375047684,
0.028619710355997086,
-0.007621046621352434,
-0.020579157397150993,
0.027151435613632202,
0.009753541089594364,
-0.027151435613632202,
0.014472996816039085,
-0.026568787172436714,
-0.04791703820228577,
-0.025753078982234,
0.002125211525708437,
0.01828351989388466,
-0.006665502674877644,
-0.018796252086758614,
0.03966673091053963,
-0.009491349570453167,
0.04076211154460907,
0.026778539642691612,
0.03563480079174042,
-0.022816527634859085,
0.0324418880045414,
0.016535574570298195,
-0.0054390267468988895,
-0.035355132073163986,
-0.009112627245485783,
-0.011687935329973698,
-0.012608520686626434,
0.03169609606266022,
-0.015405234880745411,
0.01835343800485134,
-0.00913010723888874,
0.026498869061470032,
0.007924024015665054,
0.0030763857066631317,
-0.01077317725867033,
0.02463439293205738,
-0.019262369722127914,
-0.004029016476124525,
0.008867914788424969,
-0.016279207542538643,
0.013925307430326939,
-0.010738218203186989,
-0.03654373437166214,
-0.014088449068367481,
-0.0028753720689564943,
0.008512499742209911,
0.00040931080002337694,
0.011792812496423721,
-0.04435122758150101,
0.005345803219825029,
-0.03132320195436478,
0.031253281980752945,
0.041950713843107224,
0.07961313426494598,
-0.03815184533596039,
0.06054886430501938,
-0.05961662903428078,
-0.01716483384370804,
-0.025240346789360046,
0.011029542423784733,
0.006508187390863895,
0.01658218540251255,
-0.043815191835165024,
0.03626406192779541,
0.012771662324666977,
0.007143274415284395,
0.010009907186031342,
0.04029599204659462,
0.009345686994493008,
0.013354310765862465,
-0.018959393724799156,
-0.04724116623401642,
-0.029924843460321426,
0.0303676575422287,
-0.017747484147548676,
-0.020952051505446434,
-0.06465071439743042,
0.034446198493242264,
-0.019052617251873016,
-0.015463500283658504,
-0.011408263817429543,
0.007300589699298143,
-0.01292315125465393,
-0.0034492809791117907,
-0.05681991204619408,
0.05901067331433296,
0.04358213394880295,
-0.01227058470249176,
-0.01678028702735901,
-0.06786693632602692,
-0.026265809312462807,
-0.010505158454179764,
-0.017001692205667496,
-0.04500379413366318,
0.012258931063115597,
0.019367247819900513,
0.026638705283403397,
0.005727437790483236,
-0.036776792258024216,
0.0014675466809421778,
0.010056518949568272,
-0.002517042914405465,
-0.008978618308901787,
-0.030297739431262016,
-0.05052730813622475,
0.04791703820228577,
0.003586203558370471,
0.03554157912731171,
-0.01185107696801424,
-0.05947679281234741,
-0.02419157885015011,
-0.03188254311680794,
0.006187730468809605,
-0.05537494271993637,
0.012247278355062008,
0.021954208612442017,
-0.00763269979506731,
-0.00740546640008688,
-0.02162792533636093,
0.06744743138551712,
-0.04064558073878288,
-0.013797123916447163,
-0.0049146427772939205,
0.04299948364496231,
0.03421314060688019,
-0.0010524094104766846,
-0.04959506914019585,
0.03971334546804428,
-0.005497291684150696,
0.028689628466963768,
-0.014076795428991318,
-0.018050460144877434,
0.03192915394902229,
-0.035751331597566605,
-0.0015017773257568479,
0.008867914788424969,
0.004093108233064413,
-0.02887607552111149,
-0.023096200078725815,
0.0016853117849677801,
0.0030589064117521048,
-0.04833654686808586,
-0.044188085943460464,
-0.02475092187523842,
-0.028619710355997086,
-0.06609567999839783,
0.0017260971944779158,
0.009724409319460392,
0.01771252416074276,
-0.010394454933702946,
-0.03843151777982712,
-0.03025112673640251,
0.009905030019581318,
-0.010429413989186287,
0.03267494589090347,
-0.03381693735718727,
0.011886036023497581,
-0.016838550567626953,
-0.01470605656504631,
-0.02698829397559166,
0.0033298381604254246,
-0.0021368644665926695,
0.03700985386967659,
0.09546118229627609,
-0.00801142118871212,
-0.01241041999310255,
0.006479055155068636,
-0.019075922667980194,
0.007591914385557175,
-0.002850609365850687,
-0.0032016553450375795,
-0.020182956010103226,
0.020975356921553612,
0.024051744490861893,
0.008069686591625214,
0.028456568717956543,
-0.005663346499204636,
0.01002155989408493,
-0.0032511805184185505,
-0.040249381214380264,
0.03453942388296127,
-0.010336190462112427,
-0.004197984933853149,
-0.0021485176403075457,
0.02369050122797489,
-0.036590345203876495,
0.004396085627377033,
0.028712933883070946,
-0.02603274956345558,
0.0193789005279541,
-0.03530851751565933,
0.005275885108858347,
0.04237022250890732,
0.006315913517028093,
0.027873920276761055,
0.040715500712394714,
-0.009602053090929985,
0.05248500779271126,
-0.005966323893517256,
-0.006613064091652632,
0.004620405379682779,
-0.009077669121325016,
-0.02267669327557087,
-0.04139137268066406,
-0.02371380664408207,
0.0034755002707242966,
0.01255025528371334,
-0.015078951604664326,
0.0017333802534267306,
-0.018994351848959923,
-0.007504516746848822,
0.012352155521512032,
0.004241683520376682,
-0.0431160144507885,
-0.006974306423217058,
0.012212319299578667,
-0.010516811162233353,
-0.058031823486089706,
-0.004993300419300795,
0.0007301318109966815,
0.007248151581734419,
-0.003714386373758316,
-0.04581950232386589,
0.014554567635059357,
-0.012946456670761108,
0.026755234226584435,
-0.02931888960301876,
0.014997380785644054,
-0.002307289279997349,
0.016442349180579185,
0.0593835674226284,
0.00941560510545969,
0.00459418585523963,
0.005022433120757341,
0.020171303302049637,
-0.04509701952338219,
0.011181031353771687,
0.0004923382657580078,
0.03232535719871521,
-0.04738100245594978,
0.01115189865231514,
0.005348716396838427,
-0.011763679794967175,
-0.012433726340532303,
-0.018108725547790527,
-0.01770087145268917,
-0.013505799695849419,
0.011349999345839024,
-0.027710778638720512,
-0.01363398227840662,
-0.003463847329840064,
-0.039759956300258636,
0.014857545495033264,
-0.001090281642973423,
-0.00761522026732564,
0.0016780286096036434,
-0.005730351433157921,
0.021511394530534744,
-0.014216631650924683,
-0.011495660990476608,
0.040435828268527985,
0.008885394781827927,
0.03027443215250969,
0.031346507370471954,
0.007644352503120899,
-0.013552411459386349,
-0.005444853100925684,
-0.028782851994037628,
-0.007970635779201984,
-0.03169609606266022,
-0.015999536961317062,
0.00857076421380043,
0.014950769022107124,
0.023375870659947395,
-0.06329897046089172,
0.009351513348519802,
-0.006881082430481911,
0.003708559786900878,
0.05998952314257622,
0.007533649448305368,
0.0012650762218981981,
0.011548100039362907,
-0.008733905851840973,
0.022094042971730232,
0.02239702083170414,
-0.05094681307673454,
-0.016430696472525597,
-0.0028549793642014265,
-0.006042068358510733,
0.004139719996601343,
-0.024005131796002388,
-0.03477248176932335,
-0.010050692595541477,
0.035751331597566605,
-0.02997145615518093,
0.020252874121069908,
-0.009252463467419147,
-0.023096200078725815,
0.01865641586482525,
0.021686188876628876,
-0.036217451095581055,
0.030577410012483597,
0.018120378255844116,
0.006001282949000597,
-0.015172175131738186,
-0.01592961885035038,
0.04223038628697395,
-0.01712987571954727,
-0.012212319299578667,
0.03176601231098175,
-0.0044776564463973045,
-0.0033298381604254246,
0.010610034689307213,
-0.010738218203186989,
0.0025447187945246696,
-0.005133136175572872,
0.0176193006336689,
0.007976462133228779,
-0.023352565243840218,
-0.02042766846716404,
0.01779409497976303,
0.004052322823554277,
0.0020378143526613712,
-0.03176601231098175,
0.024774227291345596,
0.009287422522902489,
-0.0024063396267592907,
-0.020637420937418938,
-0.00409602141007781,
0.013412576168775558,
0.0042766425758600235,
-0.03307114914059639,
0.00020829695858992636,
-0.02444794401526451,
-0.016419043764472008,
-0.01521878782659769,
0.021569659933447838,
-0.011268428526818752,
-0.010720738209784031,
-0.014461344107985497,
0.0021732801105827093,
-0.011979259550571442,
0.015393582172691822,
-0.009939989075064659,
0.0033181849867105484,
-0.01582474261522293,
0.041950713843107224,
0.026452256366610527,
0.007568608038127422,
0.013529106043279171,
0.011967606842517853,
0.0067645530216395855,
-0.02182602509856224,
0.005514771211892366,
0.021429823711514473,
-0.005054478533565998,
-0.011111113242805004,
-0.016931774094700813,
0.04460759460926056,
0.046518683433532715,
-0.0012242908123880625,
-0.00767931155860424,
-0.04264989495277405,
-0.015020687133073807,
-0.016267554834485054,
-0.03197576850652695,
0.01986832544207573,
0.01601118966937065,
0.017001692205667496,
0.0026190064381808043,
-0.05062052980065346,
-0.01752607710659504,
0.005843967664986849,
0.016990039497613907,
0.004378606099635363,
0.010231313295662403,
0.010563422925770283,
-0.03185923770070076,
0.013575717806816101,
-0.01967022381722927,
-0.006653849501162767,
0.003731865668669343,
0.009287422522902489,
0.01156557910144329,
-0.019949896261096,
-0.03453942388296127,
-0.03027443215250969,
0.014647791162133217,
0.035355132073163986,
0.023375870659947395,
0.06087515130639076,
-0.018400050699710846,
0.011979259550571442,
-0.001356115099042654,
-0.0090951481834054,
-0.020649073645472527,
0.011466529220342636,
-0.0055060312151908875,
-0.005500204861164093,
0.008454234339296818,
-0.0193789005279541,
-0.0005691750557161868,
-0.018015502020716667,
-0.00900192465633154,
-0.03465595096349716,
-0.022618427872657776,
0.003484240034595132,
0.0064324429258704185,
0.022443633526563644,
0.01856319233775139,
-0.037336137145757675,
-0.013738859444856644,
0.0273611880838871,
0.047637369483709335,
-0.046798352152109146,
0.054675765335559845,
0.004672843497246504,
-0.04078541696071625,
-0.020369403064250946,
-0.011489834636449814,
-0.013097945600748062,
-0.009887550957500935,
0.005841054487973452,
0.03859465941786766,
-0.010540117509663105,
-0.019332287833094597,
-0.022723304107785225,
0.008827129378914833,
0.009625358507037163,
-0.027104822918772697,
-0.006036242004483938,
0.025613242760300636,
-0.016745327040553093,
0.014181672595441341,
0.05267145484685898,
0.008844609372317791,
-0.0038046969566494226,
-0.04458428919315338,
0.012037524953484535,
0.00735885463654995,
-0.022362062707543373,
-0.03966673091053963,
-0.02135990560054779,
-0.02586960792541504,
0.006269301287829876,
0.006991785950958729,
0.015801435336470604,
-0.036124225705862045,
0.021103540435433388,
-0.006391657516360283,
0.0007334091933444142,
0.001205354812555015,
0.02444794401526451,
0.009427257813513279,
0.014030183665454388,
0.04113500565290451,
-0.01985667273402214,
0.05113326013088226,
-0.00970110297203064,
-0.018703026697039604,
0.055701229721307755,
-0.03286139294505119,
0.022641733288764954,
0.005948844365775585,
-0.008797997608780861,
-0.003484240034595132,
0.0007126523414626718,
-0.017549382522702217,
-0.008291092701256275,
-0.003492979798465967,
-0.027198046445846558,
0.03526190668344498,
-0.033677101135253906,
0.008535805158317089,
-0.03365379571914673,
0.028712933883070946,
-0.034049998968839645,
-0.027687471359968185,
0.008780517615377903,
-0.003335664514452219,
-0.003918313421308994,
0.014298202469944954,
-0.013389269821345806,
-0.017118223011493683,
0.025799689814448357,
-0.08026570081710815,
-0.047544144093990326,
0.02503059431910515,
0.0234224833548069,
-0.022455286234617233,
0.030857082456350327,
0.014484649524092674,
0.026685316115617752,
0.032278746366500854,
-0.024611085653305054,
0.005645866971462965,
-0.05024763569235802,
-0.002279613632708788,
-0.02857309766113758,
-0.043978333473205566,
0.023445788770914078,
-0.001356115099042654,
-0.006624717265367508,
-0.012445379048585892,
-0.005144789349287748,
-0.03449280932545662,
0.04607586935162544,
0.008891221135854721,
0.021499741822481155,
0.011687935329973698,
-0.009596225805580616,
-0.02230379730463028,
-0.029365500435233116,
-0.0027734083123505116,
0.018761292099952698,
-0.010779003612697124,
-0.010779003612697124,
0.00242527574300766,
0.031183365732431412,
-0.008302745409309864,
-0.056260570883750916,
0.002936550183221698,
-0.021441476419568062,
0.010621688328683376,
-0.00308221229352057,
0.011309213936328888,
0.03279147669672966,
0.01053429115563631,
0.016931774094700813,
0.0008433841867372394,
0.0006223417585715652,
-0.03927053138613701,
0.01763095334172249,
0.011635497212409973,
-0.01985667273402214,
0.014985728077590466,
-0.013657288625836372,
-0.02847987413406372,
-0.015288705006241798,
-0.005567209329456091,
-0.030018066987395287,
0.025822995230555534,
0.02838665060698986,
0.02315446361899376,
-0.008693120442330837,
-0.008996098302304745,
0.04982812702655792,
0.01694342866539955,
-0.03006467968225479,
-0.0050603048875927925,
0.007207366172224283,
-0.026498869061470032,
0.04227699711918831,
-0.03985317796468735,
0.021860983222723007,
0.0078249741345644,
-0.008454234339296818,
-0.029248971492052078,
0.0361708402633667,
-0.026592092588543892,
0.00825030729174614,
0.0036415550857782364,
-0.012433726340532303,
-0.004305774811655283,
-0.00552933756262064,
-0.0031987421680241823,
0.0014129234477877617,
0.01751442439854145,
0.027198046445846558,
-0.01835343800485134,
0.02334091253578663,
0.017770789563655853,
-0.013272739946842194,
0.004646624438464642,
-0.01968187652528286,
-0.008722253143787384,
-0.01476432103663683,
-0.011035368777811527,
0.03558818995952606,
0.03391016274690628,
-0.04584281146526337,
-0.046891577541828156,
-0.019833365455269814,
-0.02538018301129341,
-0.01968187652528286,
0.03626406192779541,
-0.031439729034900665,
0.00043152429861947894,
-0.0013124165125191212,
-0.022793222218751907,
0.011408263817429543,
0.025636548176407814,
-0.03074055165052414,
-0.005995456594973803,
-0.03241858258843422,
0.02165123075246811,
-0.0001015993912005797,
0.014414732344448566,
-0.016372432932257652,
0.04439784213900566,
0.0025782210286706686,
-0.003557071089744568,
-0.034422893077135086,
0.020870480686426163,
0.006822817958891392,
0.07397309690713882,
0.019169146195054054,
-0.01420497801154852,
-0.00047158138477243483,
-0.012806621380150318,
-0.020299484953284264,
0.02931888960301876,
0.011023716069757938,
0.0014355010353028774,
-0.007166580762714148,
0.02181437239050865,
0.006111986003816128,
0.027314577251672745,
0.0015498459106311202,
-0.03670687600970268,
0.02698829397559166,
-0.007481210865080357,
0.0007410564576275647,
0.015463500283658504,
-0.002821476897224784,
0.014228284358978271,
-0.03505215421319008,
-0.014869198203086853,
-0.022630080580711365,
0.019845018163323402,
0.0010130807058885694,
-0.044560983777046204,
0.012084136717021465,
-0.004471829626709223,
0.024401333183050156,
-0.033210981637239456,
0.017933931201696396,
0.03027443215250969,
0.038081929087638855,
-0.006362525280565023,
0.009066015481948853,
0.026475561782717705,
-0.008314399048686028,
-0.051319707185029984,
0.0009482609457336366,
0.019984854385256767,
0.041181620210409164,
-0.04150790348649025,
-0.048662830144166946,
0.017386240884661674,
0.004996213596314192,
0.0012009849306195974,
0.007801667787134647,
0.0037260393146425486,
-0.007900717668235302,
-0.0012665329268202186,
-0.023818684741854668,
0.02510051056742668,
-0.01816699095070362,
-0.03948028385639191,
-0.013272739946842194,
0.02493736892938614,
0.02528695948421955,
0.011792812496423721,
0.0148458918556571,
0.005666259676218033,
-0.022525204345583916,
-0.011414090171456337,
-0.0036182492040097713,
0.031066834926605225,
-0.019891630858182907,
-0.04677504673600197,
-0.035355132073163986,
0.02359727770090103,
0.03232535719871521,
-0.027687471359968185,
-0.0028855684213340282,
0.006374177988618612,
0.06842628121376038,
0.01779409497976303,
-0.032838087528944016,
-0.007667658384889364,
0.0034259750973433256,
-0.030763858929276466,
-0.041088394820690155,
-0.029668478295207024,
0.025659853592514992,
0.044840652495622635,
-0.003487153211608529,
0.0002245018695248291,
0.03188254311680794,
0.03018120862543583,
-0.02538018301129341,
-0.010942145250737667,
0.015591682866215706,
0.03183593228459358,
0.0718289464712143,
-0.053650304675102234,
0.020311137661337852,
-0.019903283566236496,
0.01284158043563366,
0.007184059824794531,
0.0010130807058885694,
-0.06423120945692062,
0.0019577001221477985,
-0.03698654845356941,
-0.016652103513479233,
0.027128130197525024,
-0.00992833636701107,
0.012561908923089504,
0.019996507093310356,
-0.00552933756262064,
0.003586203558370471,
-0.003530851798132062,
0.0011667542858049273,
-0.009782673791050911,
-0.003356057219207287,
0.026289114728569984,
-0.00203927094116807,
-0.013855389319360256,
-0.011903515085577965,
0.029668478295207024,
-0.03700985386967659,
-0.0016809419030323625,
-0.005747830495238304,
0.025263654068112373,
0.015684906393289566,
-0.015719864517450333,
-0.017642606049776077,
-0.020753951743245125,
-0.01781740039587021,
0.0487094409763813,
-0.030950305983424187,
-0.029155747964978218,
0.003242440754547715,
-0.0015032340306788683,
0.004448523744940758,
-0.003737692255526781,
0.0268950704485178,
0.04467751085758209,
0.010516811162233353,
0.0007126523414626718,
0.006391657516360283,
0.028619710355997086,
-0.0038775280117988586,
0.007673485204577446,
-0.028153590857982635,
0.009537961333990097,
-0.003941619303077459,
0.015242093242704868,
-0.020963704213500023,
-0.0028782852459698915,
-0.046705130487680435,
0.018971046432852745,
-0.00026783638168126345,
-0.03120667114853859,
0.03458603471517563,
-0.02278156951069832,
-0.0023407917469739914,
-0.039387062191963196,
-0.0011390784056857228,
0.03328090161085129,
-0.009782673791050911,
-0.00964283850044012,
0.0026117232628166676,
-0.03768572583794594,
-0.021021969616413116,
-0.009695276618003845,
-0.05071375519037247,
0.023655543103814125,
0.030880387872457504,
0.0045446609146893024,
-0.031812626868486404,
0.008873742073774338,
-0.008547457866370678,
-0.018772944808006287,
0.028223508968949318,
-0.026102667674422264,
0.005587602034211159,
-0.017642606049776077,
-0.01986832544207573,
-0.0018601063638925552,
0.008151257410645485,
-0.007953156717121601,
0.020963704213500023,
0.031719401478767395,
0.02512381784617901,
0.0213482528924942,
-0.020765604451298714,
0.01703665219247341,
0.01307463925331831,
-0.008116298355162144,
-0.015405234880745411,
0.029365500435233116,
-0.015614988282322884,
-0.025753078982234,
0.016617145389318466,
0.007108315825462341,
-0.005943018011748791,
0.009683623909950256,
0.00960787944495678,
-0.041834186762571335,
-0.03633398190140724,
0.04467751085758209,
0.0003823633014690131,
-0.013925307430326939,
-0.021196763962507248,
-0.011775332503020763,
0.009887550957500935,
-0.014962421730160713,
-0.019169146195054054,
0.011140245944261551,
-0.008541631512343884,
-0.010697432793676853,
-0.02350405417382717,
0.015976231545209885,
-0.01582474261522293,
0.012608520686626434,
0.007574434857815504,
0.019425511360168457,
0.03703315928578377,
0.03248849883675575,
-0.012748355977237225,
-0.0003692536847665906,
-0.008500846102833748,
-0.0042999484576284885,
-0.017176486551761627,
0.0035395915620028973,
0.03600769862532616,
0.00711996853351593,
0.0015105170896276832,
-0.019157493487000465,
-0.019891630858182907,
-0.04204393923282623,
-0.021756106987595558,
0.06558295339345932,
-0.014333161525428295,
-0.02145312912762165,
0.03253510966897011,
0.04101847857236862,
0.032278746366500854,
0.003915400244295597,
0.02894599363207817,
-0.005019519478082657,
0.009339860640466213,
-0.008757212199270725,
0.02652217447757721,
-0.0028826550114899874,
-0.00885626208037138,
0.030111290514469147,
0.027291271835565567,
0.00080842524766922,
-0.016151025891304016,
0.015451846644282341,
0.01231719646602869,
0.008075512945652008,
0.015078951604664326,
-0.024144968017935753,
0.005852707661688328,
-0.022431978955864906,
0.023305952548980713,
0.04402494430541992,
-0.0021630837582051754,
0.008757212199270725,
0.016139373183250427,
0.0030967784114181995,
-0.0016343299066647887,
0.015533417463302612,
-0.02078890986740589,
-0.02343413606286049,
-0.012072484008967876,
-0.042416833341121674,
-0.02987823262810707,
0.0007778361905366182,
-0.005864360369741917,
-0.004401911981403828,
-0.026475561782717705,
0.000561891938559711,
-0.00020738656166940928,
-0.04852299392223358,
-0.00984093826264143,
-0.02444794401526451,
-0.002029074588790536,
0.01667540892958641,
-0.009200025349855423,
-0.020765604451298714,
0.014181672595441341,
0.012946456670761108,
0.005386588629335165,
0.016710368916392326,
-0.0034696736838668585,
0.016255902126431465,
-0.01002155989408493,
0.004128066822886467,
-0.004664103966206312,
-0.035564884543418884,
-0.009846765547990799,
-0.05747247859835625,
-0.0050603048875927925,
-0.012620173394680023,
-0.0016110240248963237,
-0.0007436055457219481,
-0.01475266832858324,
-0.001444969093427062,
-0.029295582324266434,
0.03680010139942169,
-0.01584804803133011,
-0.010266272351145744,
0.0026918374933302402,
-0.031229976564645767,
-0.0070558772422373295,
0.012340501882135868,
-0.0012810991611331701,
-0.04274311661720276,
0.011676282621920109,
0.004830158781260252,
0.002732622902840376,
0.01340092346072197,
0.007318069227039814,
-0.04029599204659462,
-0.0007792927790433168,
-0.0039765783585608006,
0.012352155521512032,
-0.009485523216426373,
0.004457263741642237,
-0.007883238606154919,
0.02210569567978382,
0.04945523291826248,
0.01705995760858059,
0.006368351634591818,
-0.0039124870672822,
0.016803592443466187,
-0.013319352641701698,
0.011227643117308617,
0.019448818638920784,
-0.004506788682192564,
0.03432966768741608,
-0.002678727963939309,
-0.01058090291917324,
-0.024983981624245644,
-0.007387987338006496,
-0.02764086052775383,
-0.0010698889382183552,
0.0001331898820353672,
0.011041195131838322,
-0.026125973090529442,
-0.010149742476642132,
-0.016535574570298195,
0.013470840640366077,
-0.0007439696928486228,
0.0193789005279541,
-0.009473869577050209,
-0.010411934927105904,
-0.008698946796357632,
-0.01960030570626259,
0.004081455059349537,
0.004034843295812607,
0.0002048374735750258,
0.02717474102973938,
0.04227699711918831,
-0.02764086052775383,
0.026009444147348404,
0.005345803219825029,
0.018901128321886063,
-0.010505158454179764,
-0.003714386373758316,
0.006851950194686651,
0.007609393913298845,
-0.032278746366500854,
0.025147123262286186,
0.01180446520447731,
-0.028689628466963768,
-0.01105284783989191,
0.04616909474134445,
-0.008320225402712822,
-0.01893608644604683,
-0.02145312912762165,
0.0027311663143336773,
-0.008850435726344585,
-0.02090544067323208,
0.0013845192734152079,
0.018050460144877434,
-0.004827245604246855,
-0.033024534583091736,
-0.026825152337551117,
-0.0259628314524889,
0.0029423765372484922,
-0.005567209329456091,
-0.008180389180779457,
0.01227058470249176,
-0.007271457463502884,
-0.019437164068222046,
-0.07383325695991516,
0.009386472404003143,
0.014414732344448566,
0.0005859262309968472,
0.013261087238788605,
-0.011361652053892612,
0.03008798509836197,
0.0419740229845047,
-0.052718065679073334,
0.009823459200561047,
0.034609340131282806,
0.007993942126631737,
0.001692594843916595,
-0.013599023222923279,
-0.000664947961922735,
0.038175150752067566,
-0.011227643117308617,
-0.0012891105143353343,
-0.0025490885600447655,
0.009246637113392353,
0.05155276879668236,
-0.010254619643092155,
0.039177305996418,
0.020101385191082954,
-0.0042999484576284885,
0.010644993744790554,
-0.016151025891304016,
-0.05332402139902115,
0.0331643708050251,
-0.05015441030263901,
-0.006863603368401527,
-0.0547223761677742,
-0.05038747191429138,
-0.02125502936542034,
0.01293480396270752,
0.02484414540231228,
-0.00587892672047019,
0.01467109750956297,
-0.009864244610071182,
0.03728952631354332,
-0.017071610316634178,
-0.03495892882347107,
-0.013424228876829147,
0.007941503077745438,
-0.006001282949000597,
0.002605896908789873,
0.01853988505899906,
-0.007125795353204012,
0.0026801845524460077,
-0.019460471346974373,
0.0026175498496741056,
-0.032465193420648575,
-0.0012745442800223827,
0.021488089114427567,
0.007096662651747465,
0.02231545001268387,
-0.015568376518785954,
0.013960265554487705,
-0.011862729676067829,
0.0003896463895216584,
-0.01063916739076376,
0.014309855177998543,
-0.004693236202001572,
-0.013995224609971046,
0.028456568717956543,
-0.036403898149728775,
-0.027291271835565567,
-0.0070791831240057945,
-0.0033677101600915194,
-0.012072484008967876,
0.010557596571743488,
-0.019239064306020737,
-0.00973606202751398,
-0.00740546640008688,
-0.036497123539447784,
-0.006583931855857372,
0.00043516585719771683,
-0.011449049226939678,
-0.003816349897533655,
-0.047287777066230774,
-0.043046094477176666,
0.024051744490861893,
0.030507491901516914,
-0.047264471650123596,
-0.007353028282523155,
-0.0033822765108197927,
0.015883006155490875,
0.025426795706152916,
0.0306240227073431,
-0.0033764499239623547,
0.03908408433198929,
-0.04898911342024803,
0.024587780237197876,
-0.0025840476155281067,
0.004224203992635012,
0.012433726340532303,
-0.0248208399862051,
-0.018423356115818024,
-0.018027154728770256,
-0.027687471359968185,
-0.020753951743245125,
-0.018330132588744164,
-0.024028437212109566,
-0.02360893040895462,
-0.04087864235043526,
-0.0147177092730999,
0.013715553097426891,
0.014356466941535473,
0.0024558648001402617,
-0.003428888274356723,
-0.00459418585523963,
-0.007877412252128124,
0.024051744490861893,
0.01948377676308155,
0.032744865864515305,
-0.019542042165994644,
-0.0007454263395629823,
0.006176077760756016,
0.030600717291235924,
-0.021511394530534744,
0.0004883325309492648,
0.03411991521716118,
-0.025613242760300636,
-0.004110587295144796,
0.03127658739686012,
0.028549792245030403,
-0.026079362258315086,
-0.014834239147603512,
-0.008879568427801132,
-0.01835343800485134,
-0.016535574570298195,
-0.018201949074864388,
0.026731928810477257,
-0.02370215393602848,
0.013435881584882736,
0.013191169127821922,
0.01733962818980217,
-0.05490882694721222,
0.015591682866215706,
-0.0003932879480998963,
-0.015148869715631008,
-0.00876303855329752,
0.00861737597733736,
-0.015032339841127396,
0.02549671195447445,
0.023655543103814125,
0.0036124226171523333,
0.0036677743773907423,
-0.008943659253418446,
-0.014041836373507977,
-0.016185984015464783,
-0.037709031254053116,
0.012736703269183636,
0.009398126043379307,
-0.024797534570097923,
0.017561035230755806,
0.02521704137325287,
-0.011553926393389702,
0.016640450805425644,
0.019845018163323402,
-0.011536446399986744,
-0.04153120890259743,
0.028596404939889908,
-0.03728952631354332,
-0.023317605257034302,
-0.02540348842740059,
0.0052933646366000175,
0.11886036396026611,
-0.00412515364587307,
0.005977977067232132,
-0.0006631271680817008,
-0.003886267775669694,
-0.0006055906414985657,
0.004227117169648409,
0.010143916122615337,
0.0018426269525662065,
0.0064382697455585,
0.0000941342004807666,
0.010056518949568272,
0.04922217130661011,
0.014251590706408024,
0.020753951743245125,
-0.022175613790750504,
0.023317605257034302,
0.03474917635321617,
0.004964168183505535,
-0.0003068010264541954,
-0.012352155521512032,
-0.008774691261351109,
-0.038384903222322464,
-0.0019780928269028664,
-0.016325820237398148,
-0.00442813104018569,
-0.013097945600748062,
-0.027431106194853783,
-0.04022607579827309,
0.026545479893684387,
0.0058294013142585754,
-0.01537027582526207,
0.01659383811056614,
-0.03127658739686012,
0.014682750217616558,
-0.008087165653705597,
0.0028535225428640842,
-0.032744865864515305,
0.020089732483029366,
-0.03425975143909454,
-0.0014289462706074119,
0.005730351433157921,
-0.018225254490971565,
0.004020276945084333,
-0.012025872245430946,
0.0053603691048920155,
-0.015708211809396744,
0.007865759544074535,
-0.010266272351145744,
0.005328323692083359,
0.009805980138480663,
-0.04535338655114174,
0.009503002278506756,
-0.019984854385256767,
-0.01950708217918873,
-0.03346734866499901,
0.011262602172791958,
-0.00552933756262064,
-0.01845831423997879,
-0.03840821236371994,
-0.01242207270115614,
0.008838783018290997,
0.017572687938809395,
-0.0029380067717283964,
0.008413448929786682
] | 2025-01-21 | 78 | 39833408 | [
"engineered T cell therapies",
"malignant T cells",
"vector integration sites",
"vector integration",
"vector copy number",
"tumor suppressor genes",
"gene therapy",
"secondary malignancies",
"specific genes",
"engineered receptors",
"incident tumor samples",
"safety outcomes",
"38 T cell therapy trials",
"modest clonal expansion",
"integration",
"other indications",
"One T cell lymphoma",
"HIV-1 infection",
"insertional mutagenesis",
"gammaretroviral or lentiviral vectors",
"HIV-1",
"treatment",
"observation",
"high-level marking",
"cancer",
"more than 2,200 total patient-years",
"Long-term risks",
"176 patients",
"783 patients",
"Eighteen patients"
] | [] | 0 | 10.1038/s41591-024-03478-6
10.1056/NEJMra1706910
10.1056/NEJMra1706169
10.1016/j.ymthe.2023.11.001
10.1172/JCI35700
10.1056/NEJM200301163480314
10.1126/science.1088547
10.1172/JCI35798
10.1038/nm.2088
10.1016/j.omtm.2018.08.006
10.1016/j.ymthe.2017.09.008
10.1016/j.ymthe.2017.10.012
10.1016/j.ymthe.2020.01.001
10.1016/S0092-8674(02)00864-4
10.1182/blood-2007-01-068759
10.1038/mt.2009.16
10.1182/blood.V79.7.1768.1768
10.1016/j.micinf.2007.09.008
10.1126/sciadv.abi8795
10.1038/s41586-018-0178-z
10.1182/bloodadvances.2019000219
10.1056/NEJMp2400209
10.1038/s41591-023-02767-w
10.1200/JCO.20.01467
10.1056/NEJMc2030164
10.1186/s13045-022-01301-8
10.1016/j.bbmt.2019.08.003
10.1182/blood.2022015728
10.1056/NEJMoa2401361
10.1016/S2352-3026(23)00212-0
10.1016/S2352-3026(23)00248-X
10.1182/blood-2023-182817
10.1038/s41591-024-02826-w
10.1056/NEJMoa2401530
10.1182/blood-2023-178806
10.1182/blood.2021010858
10.1126/science.aba7365
10.1182/bloodadvances.2022007317
10.1016/j.omtm.2016.11.002
10.1016/j.omtm.2016.11.003
10.1038/s41591-022-01726-1
10.1200/JCO.19.01892
10.3389/fimmu.2022.971045
10.1038/s41590-023-01685-w
10.1038/s41586-023-06835-6
10.21037/atm-20-922
10.1002/jcp.30396
10.1038/73536
10.14715/cmb/2023.69.12.37
10.1038/nrc3179
10.1158/2159-8290.CD-22-0869
10.1093/nar/gkq929
10.1002/iub.2686
10.1101/gad.1163204
10.3389/fimmu.2013.00206
10.1016/S0140-6736(23)02747-2
10.1182/blood.2024024166
10.1182/blood.V98.6.1979
10.1056/NEJMoa1114138
10.1038/s41409-022-01756-w
10.1111/bjh.18909
10.1182/bloodadvances.2020004079
10.1056/NEJMoa2303379
10.1056/NEJMoa2213614
10.1056/NEJMoa2116596
10.1016/S0140-6736(22)00662-6
10.1056/NEJMoa2116133
10.1001/jamaoncol.2018.4934
10.1038/s41409-018-0290-6
10.1172/JCI130144
10.1073/pnas.2116764119
10.1016/j.jcyt.2024.03.484
10.1080/21645515.2023.2275457
10.1016/j.omtm.2024.101186
10.1056/NEJMoa1407222
10.1016/j.ymthe.2020.11.007
10.1371/journal.pcbi.0020157
10.1093/bioinformatics/bts004
10.1371/journal.pbio.0020234
10.1101/gr.6286907
10.1093/nar/gkr140
10.1038/nm.2057 | [
"Jadlowsky",
"Hexner",
"Marshall",
"Grupp",
"Frey",
"Riley",
"Veloso",
"McConville",
"Rogal",
"Czuczman",
"Hwang",
"Li",
"Leskowitz",
"Farrelly",
"Karar",
"Christensen",
"Barber-Rotenberg",
"Gaymon",
"Aronson",
"Bernstein",
"Melenhorst",
"Roche",
"Everett",
"Zolnoski",
"McFarland",
"Reddy",
"Petrichenko",
"Cook",
"Lee",
"Gonzalez",
"Alexander",
"Kulikovskaya",
"Ramírez-Fernández",
"Minehart",
"Ruella",
"Gill",
"Schuster",
"Cohen",
"Garfall",
"Shah",
"Porter",
"Maude",
"Levine",
"Siegel",
"Chew",
"McKenna",
"Lledo",
"Davis",
"Plesa",
"Herbst",
"Stadtmauer",
"Tebas",
"DiNofia",
"Haas",
"Haas",
"Myers",
"O'Rourke",
"Svoboda",
"Tanyi",
"Aplenc",
"Jacobson",
"Ko",
"Cohen",
"June",
"Bushman",
"Fraietta"
] | [
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Infectious Diseases, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.",
"Department of Medicine, Division of Infectious Diseases, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nLerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nBasser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.",
"Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Pediatrics, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.",
"Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.",
"Department of Medicine, Division of Hematology/Oncology, University of California, San Francisco, San Francisco, CA, USA.",
"Department of Medicine, Division of Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. [email protected].\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].",
"Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].\nAbramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].\nDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].\nParker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA. [email protected].\nDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected]."
] | [
"39833408",
"31365802",
"29972754",
"37927037",
"18688285",
"12529469",
"14564000",
"18688286",
"20098431",
"30211249",
"28970045",
"29203150",
"31968213",
"12202041",
"17507662",
"19259065",
"1373087",
"18024124",
"8174106",
"34644108",
"29849141",
"31387880",
"38265704",
"38195751",
"33021872",
"33596362",
"35794616",
"35325065",
"38865660",
"37689081",
"37689082",
"38266761",
"38865661",
"33974080",
"32029687",
"35349631",
"28344990",
"28344988",
"35314843",
"31815579",
"36268015",
"38012417",
"38093011",
"33145269",
"33973242",
"10700188",
"38063089",
"22129804",
"37378557",
"20952405",
"36300671",
"14752011",
"23885256",
"38071978",
"38483155",
"11535538",
"22571202",
"37287117",
"34543400",
"37272512",
"36762851",
"34904798",
"35717989",
"34891224",
"30476975",
"31845905",
"35064087",
"38639669",
"37968136",
"38282894",
"25317870",
"33186691",
"17166054",
"22238265",
"15314653",
"17545577",
"21415009",
"19966782"
] | [] | 6.571954 | 4.618594 |
39832905 | 12 | CD19-directed chimeric antigen receptor T-cell therapy: what can we learn from the haematologist? | CD19-directed chimeric antigen receptor (CAR) T-cell therapy, originally developed for haematological malignancies, has recently emerged as a promising therapy for patients with autoimmune diseases. By selectively depleting CD19-positive B-cells, this therapy brings a new approach in resetting immune dysregulation and potentially providing long-term remission for patients with a refractory disease. Recent reports have highlighted its effectiveness in conditions such as SLE, systemic sclerosis and myositis. However, while these early results are encouraging, questions remain regarding strategies for optimal patient selection and minimising toxicity on the short and long term. The experiences with CD19 CAR T-cell therapy in haematology may offer valuable insights for immunologists and rheumatologists. This article reviews the key principles learnt in haematology, the results and the mechanisms behind its efficacy, toxicities, and the challenges that need to be addressed for its broader application in clinical practice. | [
0.019357407465577126,
0.013966148719191551,
0.06678654253482819,
0.050659243017435074,
0.01608082465827465,
-0.01273452490568161,
-0.017033590003848076,
0.018381403759121895,
0.010242230258882046,
0.018183879554271698,
-0.01915988326072693,
-0.02944277971982956,
-0.05144933983683586,
0.010869661346077919,
0.06483453512191772,
-0.04378074035048485,
0.04387369379401207,
0.004150920547544956,
0.035345278680324554,
0.05177467688918114,
0.013269003480672836,
0.018718358129262924,
-0.0070353602059185505,
-0.003055821405723691,
-0.011688807047903538,
-0.04331597685813904,
0.006733263842761517,
0.014686532318592072,
-0.0060884044505655766,
-0.05558573827147484,
0.002608486218377948,
-0.015406916849315166,
0.010521087795495987,
-0.0012367070885375142,
0.007430409546941519,
0.032556697726249695,
0.04545389115810394,
0.0023978902027010918,
-0.041944924741983414,
-0.0465460829436779,
0.03732052445411682,
-0.005995451472699642,
0.01628996804356575,
0.07519876956939697,
-0.08667843043804169,
-0.03460165858268738,
0.01541853602975607,
-0.039109863340854645,
0.03536851704120636,
-0.026259148493409157,
-0.026630960404872894,
0.017021970823407173,
-0.05200705677270889,
0.03267288953065872,
-0.03989996388554573,
0.04538417607545853,
-0.026050005108118057,
0.02577114664018154,
-0.0007603243575431406,
-0.02428390271961689,
0.016905779018998146,
0.009254607371985912,
-0.009516037069261074,
-0.014186912216246128,
-0.0571194589138031,
0.017207875847816467,
-0.0418984480202198,
-0.015709012746810913,
-0.0011132543440908194,
-0.002729034284129739,
0.010300325229763985,
-0.013873196206986904,
0.04043444246053696,
-0.005757260136306286,
0.04796361178159714,
-0.002447271253913641,
-0.01404748298227787,
0.027351344004273415,
0.02132103405892849,
0.029140682891011238,
-0.006262690760195255,
0.010631469078361988,
-0.007662791293114424,
-0.06576406210660934,
-0.004377493169158697,
0.0007828363450244069,
0.0245395228266716,
-0.016185395419597626,
-0.012688049115240574,
0.010706993751227856,
0.01252538152039051,
0.011351853609085083,
-0.06046575680375099,
0.02809496596455574,
0.008969939313828945,
-0.011468044482171535,
-0.02365647256374359,
-0.04759180173277855,
0.020716842263936996,
0.029628684744238853,
0.05846727266907692,
0.007174789439886808,
0.002403699792921543,
-0.005263448692858219,
0.04419902712106705,
-0.008510985411703587,
-0.04010910540819168,
-0.01430310308933258,
0.013141193427145481,
-0.023958569392561913,
0.042874451726675034,
0.004923590458929539,
0.0076918392442166805,
0.041735779494047165,
-0.02670067362487316,
-0.0452679842710495,
-0.01717301830649376,
-0.017835306003689766,
-0.017358923330903053,
0.018555691465735435,
-0.02077493630349636,
0.04408283531665802,
0.04733618348836899,
-0.014523865655064583,
0.007680220063775778,
-0.02614295855164528,
0.06074461340904236,
-0.04217730462551117,
-0.05089162290096283,
-0.08068297803401947,
0.05521392822265625,
0.025097239762544632,
0.008638795465230942,
-0.022227324545383453,
-0.07157360762357712,
0.001047896919772029,
0.008563270792365074,
-0.010492040775716305,
-0.05707298219203949,
-0.03455518186092377,
0.032138410955667496,
-0.007302599493414164,
-0.019566550850868225,
0.004903256893157959,
-0.02872239612042904,
-0.06413739174604416,
-0.006558977533131838,
0.01047461200505495,
-0.024981047958135605,
0.03829652816057205,
-0.03406718000769615,
0.03669309243559837,
0.06915684044361115,
0.012025760486721992,
0.0009135511354543269,
-0.052192963659763336,
-0.009016416035592556,
0.03364889323711395,
-0.022982563823461533,
-0.06037280336022377,
-0.035856518894433975,
-0.006680977996438742,
-0.028582967817783356,
-0.04545389115810394,
0.0247486662119627,
-0.041271016001701355,
-0.005472592543810606,
0.0247486662119627,
-0.02804848924279213,
0.021936846897006035,
-0.04847485199570656,
-0.03295174613595009,
-0.08323917537927628,
-0.01793987862765789,
-0.048660758882761,
0.02979135327041149,
0.026096481829881668,
0.03783176466822624,
-0.03739023953676224,
-0.039783772081136703,
0.01866026222705841,
0.0012388856848701835,
0.011131090112030506,
-0.02018236368894577,
-0.049776192754507065,
-0.007854506373405457,
-0.022738562896847725,
-0.010038895532488823,
-0.050659243017435074,
-0.00546968774870038,
0.00924298819154501,
0.02639857865869999,
0.04645312950015068,
0.016359681263566017,
0.010834803804755211,
-0.002547485986724496,
0.0478241853415966,
0.046894658356904984,
-0.04917199909687042,
-0.028652681037783623,
0.025097239762544632,
-0.008284413255751133,
-0.03439251333475113,
0.01216518972069025,
-0.02144884504377842,
0.019485218450427055,
-0.015255868434906006,
0.001594720408320427,
-0.009481179527938366,
-0.007418790366500616,
0.024911334738135338,
-0.018846167251467705,
-0.016022728756070137,
0.020844651386141777,
-0.03330031782388687,
-0.0070295510813593864,
0.011775949969887733,
0.04819599539041519,
0.045337699353694916,
0.01760292425751686,
-0.027699915692210197,
-0.01738216169178486,
0.0016266729217022657,
0.01891588233411312,
-0.03820357471704483,
-0.0026128434110432863,
0.02319170907139778,
-0.029884304851293564,
-0.020867889747023582,
-0.020159125328063965,
0.019229598343372345,
0.02140236832201481,
0.03402070328593254,
-0.03608890250325203,
0.0036164424382150173,
-0.020740080624818802,
0.004267111886292696,
0.034043941646814346,
0.056422311812639236,
-0.023029040545225143,
-0.0029890115838497877,
0.011752711609005928,
0.03139478713274002,
-0.010044705122709274,
-0.02500428631901741,
-0.014558723196387291,
-0.001734149525873363,
-0.06409091502428055,
0.02551552653312683,
-0.0035728709772229195,
-0.022750182077288628,
0.02897801622748375,
-0.03836624324321747,
-0.007012122310698032,
0.015627678483724594,
-0.0033114412799477577,
0.028885062783956528,
-0.05930384621024132,
-0.008749176748096943,
-0.011706235818564892,
-0.0030819643288850784,
-0.009684513323009014,
-0.012560239061713219,
-0.05381963774561882,
-0.03827328979969025,
-0.009324321523308754,
0.0003979539033025503,
0.014535484835505486,
0.04666227474808693,
0.0015511488309130073,
0.025445811450481415,
0.026793627068400383,
0.04069006070494652,
-0.009905275888741016,
-0.04538417607545853,
0.03037230670452118,
0.018602166324853897,
0.01979893259704113,
-0.00036237045424059033,
0.04310683161020279,
0.013385194353759289,
-0.006431167479604483,
0.008743367157876492,
-0.02521342970430851,
0.0023514137137681246,
-0.005359306465834379,
0.011688807047903538,
-0.02402828261256218,
0.0020435077603906393,
-0.0038662529550492764,
-0.01835816539824009,
-0.005533592775464058,
-0.018927501514554024,
-0.020623888820409775,
0.015221010893583298,
0.008510985411703587,
-0.007622124627232552,
-0.004819018766283989,
-0.030744118615984917,
0.02170446515083313,
-0.02233189530670643,
0.03020964004099369,
0.012292999774217606,
-0.02314523234963417,
0.02196008525788784,
0.010515278205275536,
-0.0030035353265702724,
-0.03980701044201851,
0.03218488767743111,
0.044617313891649246,
0.006692597176879644,
0.0033753463067114353,
0.021948466077446938,
0.03432279825210571,
0.0012853620573878288,
0.0017602924490347505,
-0.0005809545982629061,
-0.051263436675071716,
0.01430310308933258,
-0.043478645384311676,
-0.0188229288905859,
-0.010294515639543533,
-0.01577872782945633,
0.02484161965548992,
-0.012699668295681477,
-0.03478756174445152,
0.0076918392442166805,
-0.02128617651760578,
0.00014169845962896943,
-0.04426874220371246,
0.016487492248415947,
-0.03706490620970726,
0.05368020758032799,
-0.01425662636756897,
0.00449368404224515,
-0.00029646840994246304,
-0.031046215444803238,
-0.0461045578122139,
0.032510221004486084,
-0.005553926341235638,
0.006117451936006546,
0.03388127312064171,
-0.04721999168395996,
0.07041169703006744,
0.02031017281115055,
-0.011078804731369019,
-0.009916895069181919,
0.010143467225134373,
0.00015349910245276988,
0.011357663199305534,
0.0019331264775246382,
0.004153825342655182,
0.00844127032905817,
-0.005797927267849445,
-0.03072088025510311,
0.030744118615984917,
-0.04742913693189621,
-0.010614041239023209,
-0.009864609688520432,
-0.007924221456050873,
0.008975748904049397,
0.011921188794076443,
-0.05223944038152695,
0.052983060479164124,
0.06269662082195282,
0.0643232986330986,
-0.026096481829881668,
0.03662337735295296,
-0.04196816310286522,
-0.03857538849115372,
-0.0019708885811269283,
-0.026212671771645546,
0.0004291802179068327,
0.02255265787243843,
-0.02635210193693638,
0.023888854309916496,
0.0304652601480484,
0.0052779726684093475,
0.0107883270829916,
0.019217979162931442,
0.021355891600251198,
0.0011321352794766426,
-0.020147506147623062,
-0.035763565450906754,
-0.016603682190179825,
0.007430409546941519,
-0.0027551772072911263,
-0.019485218450427055,
-0.06613587588071823,
0.035902995616197586,
-0.01874159649014473,
-0.019601408392190933,
0.0015656726900488138,
-0.0030645355582237244,
-0.004760923329740763,
0.08049707114696503,
-0.033114414662122726,
0.09141901880502701,
0.05419144779443741,
0.004290349781513214,
0.006367262452840805,
-0.03355593979358673,
-0.0024821285624057055,
-0.04754532501101494,
-0.0007051336579024792,
0.022053036838769913,
0.01928769424557686,
0.0014807081315666437,
0.030442021787166595,
-0.018927501514554024,
0.003508965950459242,
0.020170744508504868,
0.04659255966544151,
0.011415758170187473,
-0.0120606180280447,
-0.02101893723011017,
-0.03292850777506828,
0.04041120409965515,
-0.037204332649707794,
0.02758372575044632,
0.046639036387205124,
-0.013629195280373096,
0.01750997267663479,
-0.023575138300657272,
0.015836823731660843,
0.009115178138017654,
0.043687786906957626,
0.028280870988965034,
-0.031882788985967636,
-0.02635210193693638,
-0.04233997315168381,
0.05419144779443741,
0.010921946726739407,
0.006111642811447382,
0.0018314594635739923,
0.04742913693189621,
-0.030070211738348007,
-0.0068901218473911285,
-0.01701035164296627,
0.02162313088774681,
-0.005025257356464863,
0.02670067362487316,
0.011357663199305534,
-0.007221265695989132,
0.016777969896793365,
0.023958569392561913,
0.024005044251680374,
0.03278907760977745,
-0.04001615568995476,
0.0017588400514796376,
0.000013411881809588522,
-0.037669096142053604,
-0.012781001627445221,
-0.01332709938287735,
-0.03520584851503372,
0.00593445124104619,
0.029256874695420265,
-0.05651526525616646,
0.018857786431908607,
0.0528901070356369,
0.023029040545225143,
-0.023586757481098175,
0.0346946083009243,
-0.001217826153151691,
-0.006942407693713903,
0.06348671764135361,
0.057770125567913055,
-0.0016455539735034108,
0.02386561594903469,
-0.03476432338356972,
-0.012595096603035927,
0.006721645127981901,
-0.003424727590754628,
0.024446571245789528,
-0.009150035679340363,
0.035600900650024414,
0.013478146865963936,
0.012397571466863155,
0.017335684970021248,
0.021646369248628616,
-0.02022884041070938,
-0.0023848186247050762,
0.0029585114680230618,
-0.028420299291610718,
0.048800189048051834,
-0.006593835074454546,
-0.007412980776280165,
-0.017242733389139175,
-0.03439251333475113,
0.04666227474808693,
0.0018561499891802669,
0.0010340992594137788,
0.016894159838557243,
-0.009800704196095467,
-0.017080066725611687,
-0.032091934233903885,
0.033695366233587265,
0.003325965255498886,
-0.0007160265813581645,
0.02551552653312683,
0.007680220063775778,
0.01262995321303606,
0.016185395419597626,
0.0376458577811718,
0.04510531574487686,
0.021948466077446938,
0.005336068104952574,
0.0439898855984211,
0.0102596590295434,
0.0018532451940700412,
-0.04289769008755684,
0.011462234891951084,
0.034462228417396545,
-0.046220749616622925,
-0.04512855410575867,
-0.0024138663429766893,
-0.07496638596057892,
-0.028954777866601944,
-0.005141448229551315,
-0.018474357202649117,
-0.009295273572206497,
-0.010660517029464245,
0.007517552934587002,
0.009330131113529205,
0.02000807784497738,
-0.01696387492120266,
-0.006460215430706739,
-0.03460165858268738,
-0.04171254113316536,
-0.001304243109188974,
0.015685774385929108,
-0.0016484587686136365,
0.009800704196095467,
0.03685576096177101,
-0.019531695172190666,
-0.02788582257926464,
-0.02018236368894577,
0.038645099848508835,
-0.028675919398665428,
-0.028327347710728645,
0.017405400052666664,
-0.024609237909317017,
0.024934573099017143,
-0.008725938387215137,
-0.00816822238266468,
0.022575896233320236,
-0.006692597176879644,
-0.018114164471626282,
0.0008794200257398188,
-0.014337959699332714,
0.019136644899845123,
-0.030581451952457428,
0.006779740564525127,
0.0051298295147717,
0.019101787358522415,
-0.03290526941418648,
0.0033637273591011763,
-0.0363909974694252,
-0.0033927750773727894,
-0.04510531574487686,
-0.037041667848825455,
-0.025399336591362953,
-0.013617576099932194,
-0.006344024557620287,
-0.026073243468999863,
0.023540280759334564,
-0.014489008113741875,
-0.022413229569792747,
-0.05038038641214371,
0.022703707218170166,
-0.026630960404872894,
0.015720631927251816,
-0.01633644476532936,
-0.041875209659338,
0.028211155906319618,
0.023412471637129784,
-0.012200047262012959,
0.01890426315367222,
-0.00015685774269513786,
0.05014800280332565,
-0.014489008113741875,
-0.004333921242505312,
-0.01997322030365467,
0.057351838797330856,
-0.011334424838423729,
0.04875371232628822,
-0.06911036372184753,
-0.019183121621608734,
-0.012083856388926506,
-0.0070295510813593864,
0.044013120234012604,
0.02327304147183895,
0.03325384110212326,
0.02479514293372631,
-0.03578680381178856,
0.028327347710728645,
0.022947708144783974,
0.013385194353759289,
-0.010062133893370628,
-0.001583101344294846,
0.008731747977435589,
-0.04141044616699219,
0.007569838780909777,
-0.03697195276618004,
-0.00028884338098578155,
0.006698406767100096,
0.0007131217862479389,
-0.014581960625946522,
0.01709168404340744,
0.005806641187518835,
0.04378074035048485,
0.05865317955613136,
-0.008847938850522041,
0.013919672928750515,
0.01713816076517105,
0.018416261300444603,
-0.019148264080286026,
0.016069205477833748,
0.015023486688733101,
-0.007517552934587002,
-0.006593835074454546,
-0.0017254352569580078,
-0.005835689138621092,
0.008784034289419651,
0.018776454031467438,
-0.028164679184556007,
-0.015325582586228848,
0.003747157286852598,
-0.0039679198525846004,
-0.00736069492995739,
0.006704216357320547,
-0.022180847823619843,
-0.0038343004416674376,
0.027026008814573288,
-0.01006794348359108,
-0.030999738723039627,
0.049729716032743454,
-0.021890370175242424,
0.0014037316432222724,
0.0368092842400074,
-0.015767108649015427,
0.0007784792105667293,
0.021228082478046417,
-0.0038372052367776632,
0.04069006070494652,
-0.009010606445372105,
-0.020252078771591187,
0.004171254113316536,
0.01216518972069025,
-0.003726823953911662,
-0.007837077602744102,
-0.02280827797949314,
0.02263399213552475,
-0.019705981016159058,
0.011247280985116959,
-0.025631718337535858,
0.009614799171686172,
0.017149779945611954,
0.061069950461387634,
0.07096941769123077,
-0.026050005108118057,
0.013303861021995544,
-0.01997322030365467,
-0.020507698878645897,
0.007203837390989065,
-0.004377493169158697,
0.033230602741241455,
-0.012850715778768063,
0.01262995321303606,
0.012037379667162895,
0.07241018116474152,
0.008487747050821781,
-0.011531949043273926,
-0.02948925644159317,
0.0008046221337281168,
-0.009423083625733852,
0.010863851755857468,
-0.00635564373806119,
-0.018671881407499313,
0.019032074138522148,
-0.014396055601537228,
-0.012258142232894897,
-0.023842377588152885,
-0.07863801717758179,
-0.00700050313025713,
-0.005591688212007284,
0.02140236832201481,
0.006779740564525127,
0.022262180224061012,
-0.01857892796397209,
0.009463750757277012,
-0.016185395419597626,
-0.006954026874154806,
-0.005937356036156416,
0.03381155803799629,
0.02851325273513794,
-0.007819648832082748,
-0.009638037532567978,
-0.0032039647921919823,
-0.011671378277242184,
0.029303351417183876,
0.03620509058237076,
0.06720483303070068,
-0.013815101236104965,
0.021797416731715202,
-0.016998732462525368,
0.006977264769375324,
-0.0342530831694603,
0.004978781100362539,
0.03922605514526367,
0.010207372717559338,
-0.009516037069261074,
-0.0184046421200037,
-0.029605448246002197,
-0.004400731064379215,
-0.007633743807673454,
0.00398825341835618,
0.043130069971084595,
0.011671378277242184,
-0.002575081307440996,
0.00492940004914999,
0.037297286093235016,
-0.005443544592708349,
-0.0013463622890412807,
0.047568563371896744,
-0.00022856933355797082,
-0.04777770861983299,
0.0639050081372261,
-0.010422325693070889,
0.0031255357898771763,
-0.0020376984030008316,
-0.03418336808681488,
0.009382417425513268,
-0.008964129723608494,
-0.016394538804888725,
0.01712654158473015,
-0.000038170532207004726,
-0.012141951359808445,
-0.006512501277029514,
-0.019217979162931442,
0.03406718000769615,
-0.005835689138621092,
-0.038691576570272446,
0.018218737095594406,
-0.00822631735354662,
0.028745634481310844,
0.033277079463005066,
0.02319170907139778,
-0.013977767899632454,
-0.02301742136478424,
0.020670365542173386,
0.007813839241862297,
0.020995700731873512,
0.00027522724121809006,
0.0008990272763185203,
-0.04031825065612793,
-0.01038746815174818,
0.005083352793008089,
-0.029837829992175102,
-0.017800450325012207,
-0.013222526758909225,
0.031720120459795,
-0.0070527889765799046,
-0.002637533936649561,
-0.02229703776538372,
0.0016426491783931851,
0.025492288172245026,
0.021483702585101128,
-0.040550634264945984,
0.005266353487968445,
-0.02695629373192787,
-0.02183227427303791,
0.011857284232974052,
-0.012467286549508572,
-0.02402828261256218,
0.01299014501273632,
0.002026079222559929,
0.017661020159721375,
-0.011979284696280956,
0.01680120825767517,
0.008208888582885265,
0.0061348807066679,
-0.012223285622894764,
0.020042933523654938,
-0.011003280058503151,
0.007645362988114357,
0.0005871272878721356,
-0.005060114897787571,
-0.014709770679473877,
-0.016022728756070137,
0.0043135881423950195,
0.013966148719191551,
-0.032091934233903885,
0.0010348254581913352,
-0.021599892526865005,
0.019601408392190933,
0.03876129165291786,
-0.07496638596057892,
-0.008203078992664814,
0.012141951359808445,
-0.004871304612606764,
-0.009974990971386433,
0.010457183234393597,
-0.03762261942028999,
-0.006524120457470417,
-0.011142709292471409,
-0.011723664589226246,
-0.007261932827532291,
-0.01649911142885685,
0.0005083353025838733,
0.00791260227560997,
-0.009951752610504627,
-0.006111642811447382,
-0.03785500302910805,
-0.041317492723464966,
0.012978525832295418,
0.06543872505426407,
0.006797168869525194,
0.005158877000212669,
-0.023214947432279587,
0.0727819949388504,
-0.0075349812395870686,
0.00018735785852186382,
-0.020461222156882286,
0.011136899702250957,
-0.04747560992836952,
0.002689819782972336,
0.01082899421453476,
0.013408432714641094,
-0.05103105306625366,
0.006582215894013643,
-0.013547861948609352,
-0.020914366468787193,
0.02876887284219265,
-0.006332405377179384,
-0.003538013668730855,
0.003909824416041374,
-0.015836823731660843,
0.03160393238067627,
0.022750182077288628,
0.0019520075293257833,
0.0012657549232244492,
-0.017068447545170784,
-0.027142200618982315,
0.00779641093686223,
0.005443544592708349,
-0.02567819505929947,
0.0023397947661578655,
-0.00623945239931345,
-0.054888591170310974,
0.011979284696280956,
-0.0015889109345152974,
-0.029582209885120392,
-0.033277079463005066,
0.04945085570216179,
-0.0065531679429113865,
-0.012316238135099411,
-0.01028289645910263,
0.045755986124277115,
0.0465460829436779,
-0.01773073524236679,
-0.00964384712278843,
-0.005710783880203962,
-0.061534713953733444,
0.034508705139160156,
-0.0329982228577137,
-0.004792875610291958,
0.0021393653005361557,
-0.006100023631006479,
-0.023296279832720757,
0.024864858016371727,
-0.005806641187518835,
-0.004531445913016796,
-0.020066171884536743,
-0.026770388707518578,
0.01675473153591156,
-0.00366582372225821,
-0.03422984480857849,
-0.028071727603673935,
-0.029163921251893044,
0.008720128796994686,
-0.019485218450427055,
0.007058598566800356,
-0.01072442252188921,
0.04352511838078499,
0.02356351912021637,
-0.007244504056870937,
-0.026003528386354446,
0.00274501065723598,
0.004891637712717056,
-0.018172260373830795,
-0.008679461665451527,
-0.03550794720649719,
-0.034834038466215134,
0.00273484387435019,
0.025097239762544632,
-0.030023735016584396,
0.05391258746385574,
-0.05804898589849472,
0.017196256667375565,
-0.03620509058237076,
-0.01890426315367222,
-0.024655714631080627,
0.04264206811785698,
-0.012595096603035927,
-0.001042813528329134,
-0.013478146865963936,
0.035810042172670364,
-0.026677435263991356,
0.019694361835718155,
-0.006129071116447449,
0.006274309940636158,
0.009568322449922562,
0.04510531574487686,
-0.007081836927682161,
-0.009736799634993076,
0.028420299291610718,
0.06469510495662689,
0.009945943020284176,
-0.003959205932915211,
-0.029628684744238853,
-0.011735283769667149,
-0.002846677554771304,
0.027909059077501297,
0.014640056528151035,
0.0266541987657547,
0.013059860095381737,
0.023668091744184494,
0.02423742599785328,
0.004299064166843891,
0.015406916849315166,
-0.004400731064379215,
0.04940437898039818,
0.017277590930461884,
0.04735942184925079,
0.024005044251680374,
-0.00029828387778252363,
0.0032301077153533697,
0.00467377994209528,
-0.026468291878700256,
-0.0029919163789600134,
0.05381963774561882,
-0.01734730415046215,
-0.019450360909104347,
0.037669096142053604,
0.001543886843137443,
0.02670067362487316,
-0.04540741443634033,
0.032347552478313446,
0.031789835542440414,
0.07501286268234253,
0.019345788285136223,
0.021669607609510422,
0.013757005333900452,
-0.015465011820197105,
-0.006187166552990675,
-0.0026782008353620768,
-0.019310930743813515,
0.03692547604441643,
-0.026468291878700256,
-0.021553415805101395,
0.009556703269481659,
0.005379639565944672,
-0.0003502067120280117,
0.008911843411624432,
0.004098634701222181,
0.017695877701044083,
0.032208122313022614,
-0.04698760807514191,
0.016069205477833748,
-0.004057968035340309,
-0.030279355123639107,
0.002586700487881899,
-0.008818890899419785,
0.0029585114680230618,
0.021251320838928223,
0.027142200618982315,
-0.03495023027062416,
0.014930534176528454,
0.004621494095772505,
0.02186713181436062,
0.007819648832082748,
-0.003828490851446986,
-0.007320028264075518,
-0.03185955062508583,
-0.0042874449864029884,
-0.006280119530856609,
-0.025864100083708763,
-0.0308835469186306,
0.013826719485223293,
0.050752196460962296,
0.03320736438035965,
-0.03694871440529823,
-0.013908053748309612,
0.005548116751015186,
-0.05474916473031044,
-0.046429894864559174,
-0.04814951866865158,
0.041224539279937744,
0.05056628957390785,
-0.007389742881059647,
-0.019903505221009254,
0.027978774160146713,
0.001304243109188974,
-0.023168470710515976,
0.026770388707518578,
0.02348218485713005,
-0.001326755154877901,
0.013768624514341354,
-0.01726597175002098,
0.019915124401450157,
0.03660014271736145,
-0.014733009040355682,
-0.003477013437077403,
-0.0050281621515750885,
-0.026491530239582062,
-0.02013588696718216,
-0.04501236230134964,
-0.05130991339683533,
0.003799443133175373,
-0.02322656475007534,
-0.02056579291820526,
0.008679461665451527,
0.03878453001379967,
0.05061276629567146,
-0.008307650685310364,
0.0020580317359417677,
-0.003259155433624983,
0.03125535696744919,
0.029884304851293564,
-0.011171757243573666,
0.01866026222705841,
0.0023296279832720757,
0.019903505221009254,
-0.03000049665570259,
0.016870921477675438,
-0.02449304610490799,
0.0770113468170166,
0.030790595337748528,
-0.027444295585155487,
-0.02322656475007534,
-0.015162915922701359,
-0.007093456108123064,
0.054423827677965164,
-0.04066682234406471,
-0.006791359279304743,
-0.005126924719661474,
-0.03364889323711395,
0.01984540931880474,
0.02140236832201481,
0.05605050176382065,
0.02123970165848732,
0.0013361956225708127,
-0.007157361134886742,
0.018462738022208214,
0.019787313416600227,
0.021077033132314682,
-0.00827279407531023,
0.009190701879560947,
-0.011479663662612438,
-0.004975876305252314,
0.01997322030365467,
-0.0012105641653761268,
0.01848597638309002,
-0.025329621508717537,
0.0009302535909228027,
0.0065531679429113865,
0.030581451952457428,
0.012815859168767929,
0.0026491531170904636,
0.013303861021995544,
-0.005989642348140478,
-0.019020454958081245,
0.0027246770914644003,
-0.024888096377253532,
-0.004775446839630604,
0.009928514249622822,
0.019891886040568352,
-0.017835306003689766,
-0.016533968970179558,
-0.003264965023845434,
0.020833032205700874,
0.01662692055106163,
-0.0009353369241580367,
-0.042247019708156586,
0.014175293035805225,
-0.012850715778768063,
-0.031882788985967636,
0.006634501740336418,
-0.03666985407471657,
-0.01870673894882202,
-0.009248797781765461,
-0.028536491096019745,
-0.004972971510142088,
-0.01335033681243658,
0.027653438970446587,
-0.003587394719943404,
-0.015755489468574524,
0.02893153950572014,
-0.005983832757920027,
-0.029884304851293564,
0.014454150572419167,
-0.006367262452840805,
-0.03834300488233566,
-0.029884304851293564,
0.03406718000769615,
-0.021297795698046684,
-0.048381902277469635,
0.014279864728450775,
-0.005295401439070702,
0.000570787931792438,
0.009911085478961468,
0.008865367621183395,
-0.03557766228914261,
0.022854754701256752,
0.00587926059961319,
-0.0015787441516295075,
-0.025585241615772247,
-0.0031110120471566916,
0.006942407693713903,
-0.004897447302937508,
-0.035902995616197586,
0.012932050041854382,
0.0007109431899152696,
0.006779740564525127,
-0.026770388707518578,
-0.01747511513531208,
-0.0025126286782324314,
-0.009905275888741016,
-0.014117197133600712,
0.0021045079920440912,
0.015069962479174137,
0.007732505910098553,
0.01979893259704113,
0.0016426491783931851,
0.02716543711721897,
-0.013501385226845741,
-0.016104061156511307,
0.006512501277029514,
0.001893912092782557,
0.032649651169776917,
0.035810042172670364,
-0.011107852682471275,
-0.0068029784597456455,
-0.04329273849725723,
-0.008714319206774235,
0.0006016511470079422,
0.05284363031387329,
-0.010085372254252434,
-0.039411962032318115,
0.03481080010533333,
0.004502398427575827,
-0.024516284465789795,
0.007790601346641779,
-0.0120606180280447,
0.011775949969887733,
-0.00603030901402235,
-0.014372817240655422,
0.035972710698843,
0.030442021787166595,
0.004290349781513214,
-0.015755489468574524,
0.018183879554271698,
-0.032603174448013306,
0.0016920303460210562,
-0.016685016453266144,
0.007970697246491909,
0.0074594574980437756,
-0.006169738247990608,
-0.024446571245789528,
0.0013463622890412807,
-0.000558805710170418,
0.011241472326219082,
0.04996209591627121,
0.018079306930303574,
0.009940133430063725,
0.021565034985542297,
0.011648139916360378,
-0.01595301367342472,
-0.013815101236104965,
-0.0268633421510458,
-0.0071225035935640335,
-0.02305227890610695,
-0.01190956961363554,
-0.04682494327425957,
0.007099265232682228,
-0.0072851707227528095,
0.00528959184885025,
-0.022668849676847458,
0.020995700731873512,
0.0019694361835718155,
-0.035298801958560944,
0.0010950994910672307,
-0.02225056104362011,
0.007883554324507713,
-0.02005455270409584,
0.01726597175002098,
-0.02386561594903469,
-0.034369274973869324,
0.020031314343214035,
-0.03202221915125847,
-0.002685462823137641,
0.041480161249637604,
0.009638037532567978,
0.016638539731502533,
0.02018236368894577,
-0.017417019233107567,
-0.0032330125104635954,
0.009887848049402237,
-0.04501236230134964,
0.005710783880203962,
-0.020751699805259705,
-0.011921188794076443,
0.0041567301377654076,
-0.014884057454764843,
-0.04041120409965515,
0.000672454945743084,
0.006280119530856609,
-0.00022911398264113814,
0.0017631972441449761,
-0.01114851888269186,
0.005678831599652767,
0.009579941630363464,
0.021344272419810295,
0.009120987728238106,
-0.059210896492004395,
0.033950988203287125,
-0.0047957804054021835,
0.0075117433443665504,
0.005876355804502964,
0.02055417373776436,
-0.03241726756095886,
0.0005185019690543413,
-0.011241472326219082,
0.01476786658167839,
-0.01307147927582264,
-0.0090977493673563,
-0.012444048188626766,
0.004017301369458437,
0.03897043690085411,
0.0205193180590868,
0.003407298820093274,
-0.015476631000638008,
-0.026119720190763474,
0.0074420287273824215,
0.018985597416758537,
0.0035176801029592752,
0.03411365672945976,
0.027769630774855614,
-0.035298801958560944,
-0.03165040910243988,
-0.018973978236317635,
-0.009045463055372238,
-0.024353617802262306,
-0.022448087111115456,
0.009893656708300114,
0.017207875847816467,
-0.022285418584942818,
-0.00575435534119606,
-0.025538764894008636,
0.023784281685948372,
0.025097239762544632,
-0.004830637481063604,
-0.010672136209905148,
-0.012653191573917866,
-0.014477388933300972,
-0.021936846897006035,
0.01670825481414795,
0.015790347009897232,
0.021158367395401,
0.014059102162718773,
0.016278348863124847,
-0.03125535696744919,
0.008487747050821781,
0.004636018071323633,
0.012676429934799671,
-0.005216972436755896,
-0.02876887284219265,
0.019473599269986153,
-0.015523107722401619,
-0.011828236281871796,
0.00577468890696764,
0.01595301367342472,
0.011270519345998764,
-0.0209492240101099,
0.03392774984240532,
0.0026927245780825615,
-0.015790347009897232,
-0.006442786660045385,
0.0016702444991096854,
0.008052030578255653,
-0.012804239988327026,
-0.0014073625206947327,
-0.015499869361519814,
-0.010858042165637016,
0.01628996804356575,
-0.011392519809305668,
0.001382671995088458,
-0.012641572393476963,
-0.0008910391479730606,
-0.030558213591575623,
0.00894670095294714,
-0.004345540422946215,
-0.05005504935979843,
-0.06269662082195282,
-0.006785550154745579,
0.020170744508504868,
-0.061162903904914856,
-0.006245261989533901,
-0.029837829992175102,
0.02542257495224476,
0.026375340297818184,
-0.033741842955350876,
-0.0016891255509108305,
0.03460165858268738,
0.010509468615055084,
0.01271128747612238,
0.015616060234606266,
0.03355593979358673,
0.021855512633919716,
-0.011224043555557728,
-0.023296279832720757,
-0.013838338665664196,
-0.020716842263936996,
0.030651165172457695,
-0.015244249254465103,
0.031882788985967636,
0.019264455884695053,
-0.01912502571940422,
0.05223944038152695,
0.013989387080073357,
-0.02644505351781845,
0.03541499376296997,
-0.002615748206153512,
-0.016138918697834015,
-0.007482695393264294,
-0.015581202693283558,
-0.0105791836977005,
0.009167463518679142,
0.019915124401450157,
-0.01554634515196085,
0.002024626825004816,
0.0013543504755944014,
0.031673647463321686,
-0.01997322030365467,
-0.015267487615346909,
-0.004214825574308634,
0.026212671771645546,
-0.0023819138295948505,
-0.019996458664536476,
0.007848696783185005,
-0.013559481129050255,
-0.03202221915125847,
-0.0028815348632633686,
-0.0023993426002562046,
-0.01870673894882202,
-0.01186309289187193,
-0.02330789901316166,
0.022285418584942818,
0.015836823731660843,
0.015383678488433361,
0.0006455858238041401,
0.01645263470709324,
-0.0028205346316099167,
-0.004014396574348211,
-0.014186912216246128,
0.004914876073598862,
-0.017672639340162277,
-0.01611568033695221,
-0.018962359055876732,
-0.006919169332832098,
-0.0018372689373791218,
0.016533968970179558,
0.0019011739641427994,
0.0063905008137226105,
-0.0009774561040103436,
-0.01832330785691738,
0.010701184161007404,
-0.0033521081786602736,
-0.020193982869386673,
0.012153570540249348,
-0.022994183003902435,
-0.014268245548009872,
-0.04043444246053696,
-0.004499493632465601,
0.018637023866176605,
-0.006198785733431578,
-0.043432168662548065,
0.010184134356677532,
-0.00014006452693138272,
0.0020609365310519934,
0.033439747989177704,
0.04299064353108406,
-0.014140435494482517,
0.006698406767100096,
-0.027351344004273415,
-0.007087646517902613,
-0.011531949043273926,
0.02505076304078102,
-0.006256881169974804,
0.005565545056015253,
0.013664052821695805,
0.009475369937717915,
-0.012246523052453995,
-0.0186137855052948,
-0.02758372575044632,
-0.004095729906111956,
0.016441015526652336,
-0.013675672002136707,
0.0031923456117510796,
-0.010201563127338886,
-0.0016702444991096854,
0.001326755154877901,
-0.01554634515196085,
0.0016992922173812985,
0.0008264079224318266,
0.01843949966132641,
0.018381403759121895,
0.030070211738348007,
-0.02542257495224476,
0.006012880243360996,
-0.005562640260905027,
0.023203328251838684,
-0.027862584218382835,
-0.01823035627603531,
0.011212424375116825,
-0.033184126019477844,
-0.029303351417183876,
0.035345278680324554,
0.016057586297392845,
-0.02897801622748375,
-0.003860443364828825,
-0.008394794538617134,
0.00977165624499321,
-0.012037379667162895,
-0.017196256667375565,
0.021925227716565132,
-0.016359681263566017,
0.0025286050513386726,
0.011177566833794117,
0.026166196912527084,
-0.054423827677965164,
0.0342530831694603,
-0.008679461665451527,
-0.012362713925540447,
-0.01309471670538187,
-0.0039679198525846004,
0.0006503060576505959,
0.0025111762806773186,
-0.015372059307992458,
0.007261932827532291,
0.04392017051577568,
-0.0023601280990988016,
0.004464636091142893,
0.034834038466215134,
-0.007378123700618744,
-0.0009810870978981256,
0.04898609220981598,
-0.007569838780909777,
0.008365746587514877,
0.009144226089119911,
0.022773420438170433,
0.007488504983484745,
0.031673647463321686,
-0.008348317816853523,
-0.016987113282084465,
0.012246523052453995,
-0.014895676635205746,
0.004325207322835922,
-0.03711138293147087,
0.006024499423801899,
0.11135738343000412,
0.0014756247401237488,
-0.025166954845190048,
0.0047957804054021835,
-0.0072851707227528095,
-0.012792620807886124,
0.009701942093670368,
0.004891637712717056,
0.016475873067975044,
-0.007964887656271458,
0.005896689370274544,
0.008278603665530682,
0.015430154278874397,
0.01958978921175003,
0.01704520918428898,
-0.014105577953159809,
-0.00048582328599877656,
0.03418336808681488,
0.02500428631901741,
0.02008941024541855,
0.017707496881484985,
0.010352611541748047,
-0.00915584433823824,
0.0006887943018227816,
-0.01273452490568161,
-0.034369274973869324,
-0.001047896919772029,
-0.0011234210105612874,
0.00733164744451642,
-0.014849199913442135,
0.0005718772299587727,
0.017033590003848076,
0.006582215894013643,
-0.006344024557620287,
-0.01574387028813362,
-0.013083098456263542,
-0.01394291128963232,
-0.017451876774430275,
0.006012880243360996,
0.00854584202170372,
0.0052779726684093475,
0.006146499887108803,
-0.01108461432158947,
0.0060884044505655766,
0.008203078992664814,
-0.011601664125919342,
-0.01620863378047943,
0.0053564016707241535,
0.01472138985991478,
0.00047601968981325626,
-0.015104820020496845,
0.011375091038644314,
0.01938064582645893,
0.00916165392845869,
-0.032719362527132034,
-0.02352866157889366,
0.028536491096019745,
0.00697145564481616,
-0.014779485762119293,
-0.021262938156723976,
-0.0054406397975981236,
-0.0009585751104168594,
0.020170744508504868,
-0.010718612931668758,
0.023087136447429657
] | 2025-01-21 | 29 | 39832905 | [
"optimal patient selection",
"CD19 CAR T-cell therapy",
"patients",
"resetting immune dysregulation",
"haematology",
"toxicities",
"toxicity",
"systemic sclerosis",
"valuable insights",
"haematological malignancies",
"Recent reports",
"autoimmune diseases",
"clinical practice",
"CD19-directed chimeric antigen receptor",
"SLE",
"conditions",
"CAR) T-cell therapy",
"questions",
"a promising therapy",
"strategies",
"long-term remission",
"CD19-positive B-cells",
"immunologists",
"myositis",
"this therapy",
"rheumatologists",
"these early results",
"its broader application",
"the short and long term",
"the key principles"
] | [
"Autoimmune Diseases",
"Hematology",
"Lupus Erythematosus, Systemic"
] | 0 | 10.1136/lupus-2024-001157
10.1016/S1470-2045(21)00375-2
10.1016/S1470-2045(18)30864-7
10.1016/S0140-6736(20)31366-0
10.1200/JCO.19.02104
10.1182/blood-2021-148078
10.1056/NEJMoa1709866
10.1200/JCO.22.00642
10.1016/S0140-6736(21)01222-8
10.1038/s41591-021-01622-0
10.1056/NEJMoa1914347
10.1038/s41591-022-02017-5
10.1056/NEJMoa2308917
10.1016/S0140-6736(21)00933-8
10.1056/NEJMoa2024850
10.1038/s41591-022-01969-y
10.3389/fimmu.2022.867013
10.3389/fimmu.2022.927153
10.1016/j.annonc.2021.12.003
10.1016/j.eclinm.2024.102476
10.3390/cancers15174334
10.3389/fimmu.2023.1303935
10.1016/j.jtct.2023.11.008
10.1016/j.jtct.2024.01.074
10.1038/s41577-021-00547-6
10.1016/j.bbmt.2018.12.758
10.1182/blood.2022017414
10.1182/blood.2022017604
10.1111/bjh.17673
10.1182/blood.2020010543
10.1182/blood.2023020578
10.1111/tid.14157
10.1016/j.critrevonc.2023.104134
10.1038/s41591-024-03084-6
10.1111/tid.14109
10.1038/s41591-023-02767-w
10.1038/s41591-024-02826-w
10.1182/blood.2024024166 | [
"Kuipers",
"Kersten"
] | [
"Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands [email protected].",
"Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands.\nCancer Center Amsterdam, Amsterdam, The Netherlands.\nLYMMCARE Lymphoma and Myeloma Center Amsterdam, Amsterdam, The Netherlands."
] | [
"39832905",
"34516954",
"30518502",
"32888407",
"32401634",
"29385370",
"36399695",
"34097852",
"34921238",
"32242358",
"36109639",
"38381673",
"34175021",
"33626253",
"36138152",
"35757715",
"34923107",
"37951502",
"34002066",
"30592986",
"36989488",
"36877916",
"34590303",
"34166502",
"37300386",
"37739146",
"38195751",
"38266761",
"38483155"
] | [] | 7.389462 | 4.504431 |
39832454 | 13 | CAR-T cell targeting three receptors on autoreactive B cells for systemic lupus erythematosus therapy. | Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by dysregulated B cell activation, autoantibody production, and nephritis. B cell activating factor (BAFF) overexpression enhances autoreactive B-cell survival, driving autoimmunity. BAFF specific belimumab and CD20 specific rituximab antibodies are used for SLE therapy but are not curative, highlighting the need for alternative B cell depletion therapies. Here, we use BAFF ligand based chimeric antigen receptor T (CAR-T) cells targeting BAFFr, BCMA and TACI expressed on mature B cells and plasma cells. BAFF CAR-T cells efficiently killed B cells after co-culture with peripheral blood mononuclear cells (PBMCs) from SLE patients and in a patient derived SLE xenograft humanized mouse model developed by injecting patient PBMCs into immunocompromised mice. We also generated murine CD8 | [
-0.0008029377204366028,
-0.02016991190612316,
0.04874201864004135,
0.05514811351895332,
-0.03848298266530037,
0.005730088334530592,
-0.019229887053370476,
0.012672925367951393,
-0.017825651913881302,
-0.0033887308090925217,
-0.030800314620137215,
-0.0071198162622749805,
-0.03892398253083229,
-0.031635891646146774,
0.040316611528396606,
0.02569400705397129,
0.037368882447481155,
-0.013612949289381504,
-0.010972756892442703,
0.007485381327569485,
0.044935498386621475,
0.01716415397822857,
0.012429215013980865,
0.022049961611628532,
-0.01715254783630371,
-0.02259540744125843,
-0.013485291972756386,
-0.002202094765380025,
-0.006893514189869165,
-0.06327178329229355,
0.043333977460861206,
-0.0192647036164999,
0.008825787343084812,
-0.012371188960969448,
-0.027017004787921906,
0.020065464079380035,
0.02365148440003395,
0.01296305563300848,
-0.030661050230264664,
-0.04231271520256996,
0.006661409046500921,
-0.028456054627895355,
0.012672925367951393,
0.045005131512880325,
-0.05663358420133591,
-0.016641918569803238,
-0.0074041448533535,
-0.0010517251212149858,
0.04693160206079483,
-0.007148829288780689,
-0.014402106404304504,
0.024579903110861778,
-0.01625894568860531,
0.04563181474804878,
-0.023024801164865494,
0.04746544361114502,
-0.03346952050924301,
0.04971686005592346,
-0.010113968513906002,
-0.028479265049099922,
-0.0008921530097723007,
0.008570471778512001,
-0.019183466210961342,
-0.02903631702065468,
-0.04823138937354088,
0.0001781586033757776,
-0.034421149641275406,
-0.02834000252187252,
0.021806251257658005,
-0.01595720835030079,
0.01822023093700409,
-0.055890846997499466,
0.034722886979579926,
0.036997511982917786,
0.05273422226309776,
0.02162056602537632,
0.05630863830447197,
0.0355120413005352,
0.025438692420721054,
0.00884319469332695,
0.015260893851518631,
0.031635891646146774,
-0.00595348933711648,
-0.034653253853321075,
-0.016293760389089584,
0.016966864466667175,
-0.012870213948190212,
0.01694365404546261,
-0.053337693214416504,
0.009551114402711391,
0.019079018384218216,
-0.014436922036111355,
-0.0648500919342041,
0.020831409841775894,
-0.04143071547150612,
0.0366029366850853,
-0.020274359732866287,
-0.06833166629076004,
0.0002948456967715174,
0.03955066576600075,
0.008663313463330269,
0.0008043883717618883,
0.02343098446726799,
-0.07097766548395157,
0.04498191922903061,
-0.023442590609192848,
-0.008048235438764095,
-0.04358929023146629,
0.021051909774541855,
0.002730133244767785,
0.04776717722415924,
0.014506553299725056,
0.008210709318518639,
0.021191172301769257,
0.0030028566252440214,
-0.07821933180093765,
-0.03558167442679405,
0.005004760809242725,
0.023906799033284187,
0.017732810229063034,
0.02471916750073433,
0.06234336271882057,
0.09358467906713486,
-0.01972891204059124,
-0.0005871527246199548,
-0.016073260456323624,
0.08355774730443954,
-0.02471916750073433,
-0.03251789137721062,
-0.0802154392004013,
0.03915608674287796,
-0.01828986220061779,
0.028084687888622284,
-0.01956643909215927,
-0.04581749811768532,
0.011814136989414692,
-0.02162056602537632,
-0.033005308359861374,
-0.06666051596403122,
-0.028154319152235985,
0.013659370131790638,
0.018939755856990814,
0.012162294238805771,
-0.0076304469257593155,
-0.06842450797557831,
-0.05630863830447197,
0.0008159936405718327,
0.009841245599091053,
-0.0198797807097435,
0.009017273783683777,
-0.01632857695221901,
0.02910594828426838,
0.05329127237200737,
0.026320690289139748,
-0.023755932226777077,
-0.08471827208995819,
-0.008210709318518639,
0.05668000504374504,
-0.009568522684276104,
-0.04558539390563965,
-0.012162294238805771,
-0.002194841392338276,
0.006527949124574661,
-0.0176863893866539,
0.03623156622052193,
-0.021666988730430603,
0.007212658412754536,
0.044796235859394073,
-0.027318740263581276,
0.0011801080545410514,
-0.00846602488309145,
0.0027156267315149307,
-0.07589828968048096,
-0.02185267210006714,
-0.02622784860432148,
-0.0007964097894728184,
0.032610733062028885,
0.021678593009710312,
-0.026320690289139748,
-0.02652958407998085,
0.00548057584092021,
-0.002070085145533085,
0.024695957079529762,
-0.0001998277730308473,
-0.03931856155395508,
0.008779365569353104,
-0.029593368992209435,
0.024138905107975006,
0.005129517056047916,
-0.016955260187387466,
0.006278436165302992,
0.008158485405147076,
0.04718691483139992,
0.015168052166700363,
-0.0009683124371804297,
0.015783129259943962,
0.017198968678712845,
0.026924163103103638,
-0.028061477467417717,
-0.043798185884952545,
0.026622425764799118,
-0.028038265183568,
0.01813899353146553,
0.010601389221847057,
-0.03671898692846298,
0.026622425764799118,
-0.015284104272723198,
0.002666304586455226,
0.010044337250292301,
0.03864545747637749,
0.03365520387887955,
0.02003064937889576,
0.0030028566252440214,
-0.01798812672495842,
-0.01311392430216074,
0.004166282247751951,
0.0071662371046841145,
0.04159319028258324,
0.029314842075109482,
0.045701444149017334,
-0.002689515007659793,
-0.016293760389089584,
-0.008373182266950607,
0.04920622706413269,
-0.012684530578553677,
0.014796684496104717,
0.030661050230264664,
-0.0014644365292042494,
-0.031171681359410286,
-0.015086815692484379,
0.004821978509426117,
0.006881908979266882,
0.02170180343091488,
0.006968948058784008,
-0.0023166965693235397,
-0.03022005222737789,
-0.010520152747631073,
0.05677284672856331,
0.06108999624848366,
-0.04363571107387543,
0.005303595680743456,
-0.008054038509726524,
-0.01349689718335867,
-0.004462215583771467,
-0.007253276649862528,
0.013021082617342472,
0.028595317155122757,
-0.015028788708150387,
0.02757405675947666,
0.023976430296897888,
-0.022432934492826462,
-0.03869187831878662,
-0.007375131826847792,
-0.024533482268452644,
-0.013520107604563236,
0.03590662032365799,
0.00902887899428606,
-0.013009477406740189,
-0.0002892244083341211,
-0.05524095520377159,
-0.042892977595329285,
0.0012047692434862256,
-0.03430509567260742,
-0.04064156115055084,
-0.03734567016363144,
0.009046286344528198,
0.011349927634000778,
0.017512310296297073,
0.05728347599506378,
-0.004517340566962957,
0.0042852358892560005,
0.014471737667918205,
0.0017262798501178622,
-0.023930009454488754,
-0.0018321776296943426,
0.0034525597002357244,
0.0024545087944716215,
0.006139173172414303,
0.0027011202182620764,
0.017210574820637703,
0.018765676766633987,
-0.024672746658325195,
-0.017280206084251404,
-0.027481215074658394,
-0.00559082580730319,
-0.006464120000600815,
0.017094522714614868,
-0.024463851004838943,
-0.024278167635202408,
-0.02237490750849247,
-0.03145020827651024,
-0.004325854126363993,
-0.011471781879663467,
-0.017814047634601593,
-0.004972846247255802,
0.017036495730280876,
-0.036626145243644714,
-0.016595497727394104,
-0.007729091681540012,
0.03365520387887955,
-0.0400380864739418,
0.008123669773340225,
-0.01737304776906967,
-0.00027362984837964177,
0.029384473338723183,
-0.016757970675826073,
-0.004761050920933485,
-0.030173631384968758,
0.03128773346543312,
0.031937628984451294,
0.037600986659526825,
-0.024092484265565872,
0.02304801158607006,
0.031844787299633026,
0.022723065689206123,
-0.010787072591483593,
-0.02336135320365429,
-0.019995832815766335,
0.021504513919353485,
-0.0381116159260273,
-0.005286187864840031,
0.010142982006072998,
-0.024510271847248077,
0.011819939129054546,
0.018939755856990814,
-0.02373272180557251,
-0.007415750063955784,
-0.008605287410318851,
-0.03978276997804642,
-0.024765588343143463,
0.035419199615716934,
-0.017291812226176262,
0.03530314937233925,
-0.015736708417534828,
0.006342265289276838,
-0.038970403373241425,
0.006673014722764492,
-0.025345850735902786,
0.0013694185763597488,
-0.007682670373469591,
0.014692236669361591,
0.054823167622089386,
-0.04131466522812843,
0.014785079285502434,
0.002706922823563218,
-0.008796773850917816,
-0.014564579352736473,
0.018719255924224854,
0.035720936954021454,
0.02485843002796173,
0.04656023159623146,
0.014680631458759308,
0.013032687827944756,
-0.045979972928762436,
-0.025972532108426094,
-0.004888708237558603,
-0.02359345741569996,
-0.01911383494734764,
-0.011274493299424648,
-0.0015434973174706101,
0.028061477467417717,
-0.005849042441695929,
-0.02963978983461857,
0.03339988738298416,
0.03446757048368454,
0.0654071494936943,
0.015667077153921127,
-0.0045724655501544476,
-0.03597625344991684,
-0.037299249321222305,
0.015667077153921127,
-0.00786255206912756,
-0.007996012456715107,
0.043426819145679474,
-0.016885627061128616,
0.023013196885585785,
0.027875792235136032,
0.0008892517071217299,
-0.028989896178245544,
0.040548719465732574,
0.03149662911891937,
0.0008682172046974301,
-0.002409538486972451,
-0.025229796767234802,
0.016282156109809875,
0.023930009454488754,
-0.0021121541503816843,
-0.0192647036164999,
-0.04632812738418579,
0.003052178770303726,
-0.002750442596152425,
0.0012461129808798432,
0.025508323684334755,
-0.032541099935770035,
-0.02525300718843937,
0.024672746658325195,
-0.0031914417631924152,
0.09813392907381058,
0.043357186019420624,
0.019694097340106964,
0.021516120061278343,
-0.01618931256234646,
0.0037223815452307463,
-0.05412685126066208,
-0.02237490750849247,
0.00217453227378428,
0.025508323684334755,
0.017709599807858467,
0.044424869120121,
0.01522607821971178,
-0.009104312397539616,
0.004441906698048115,
0.01890493929386139,
-0.009173944592475891,
0.029918314889073372,
-0.007531802635639906,
-0.031078839674592018,
0.04254481941461563,
0.000769572623539716,
0.05510169267654419,
0.0031827378552407026,
-0.04010771960020065,
0.052037909626960754,
-0.00329588889144361,
0.018684441223740578,
-0.003847138024866581,
0.03711356595158577,
0.015562630258500576,
-0.024765588343143463,
-0.010473731905221939,
-0.01289342436939478,
0.05403400957584381,
0.014506553299725056,
0.0007782765896990895,
-0.02720268815755844,
0.021748224273324013,
-0.054312534630298615,
-0.006086949724704027,
-0.05570516362786293,
0.03855261579155922,
0.022479355335235596,
0.029500527307391167,
-0.01500557828694582,
0.024371009320020676,
-0.01935754530131817,
0.008970852941274643,
0.008872208185493946,
0.012371188960969448,
-0.023999642580747604,
0.04588712751865387,
0.011785123497247696,
-0.03114847093820572,
-0.022572197020053864,
-0.0043084463104605675,
0.02448706142604351,
-0.0012693234020844102,
0.04029340296983719,
-0.03490857034921646,
0.022247249260544777,
0.039109665900468826,
0.05222359299659729,
-0.027991844341158867,
0.020297570154070854,
-0.0059186737053096294,
-0.04468018561601639,
0.046212077140808105,
0.03175194188952446,
0.006951540242880583,
0.02312924899160862,
-0.02311764284968376,
-0.00585484504699707,
-0.00445931451395154,
0.016374997794628143,
0.0453764982521534,
-0.018382703885436058,
0.01927630789577961,
-0.03748493269085884,
-0.01410036999732256,
0.05245569720864296,
0.03323741629719734,
-0.016305366531014442,
0.006052134092897177,
-0.020355595275759697,
-0.02448706142604351,
0.016583891585469246,
0.02713305689394474,
-0.005936081521213055,
0.016340181231498718,
-0.04990254342556,
0.03490857034921646,
-0.010305455885827541,
-0.020007438957691193,
0.053244851529598236,
-0.009928285144269466,
0.008146880194544792,
-0.023454194888472557,
0.0054312534630298615,
-0.0012656967155635357,
0.024695957079529762,
-0.0007144477567635477,
-0.0010451971320435405,
0.015318919904530048,
-0.013821844011545181,
0.03544241189956665,
0.059372421354055405,
0.0005882407422177494,
0.012139083817601204,
0.010421507991850376,
-0.013694186694920063,
-0.03001115657389164,
0.004729136358946562,
-0.007636249531060457,
0.014402106404304504,
-0.02108672633767128,
-0.031102050095796585,
-0.013879870064556599,
-0.09052088856697083,
-0.0043084463104605675,
-0.030266473069787025,
-0.01410036999732256,
-0.008657511323690414,
-0.00680067203938961,
-0.0169320497661829,
-0.014007527381181717,
0.028920264914631844,
-0.02478879876434803,
-0.03890077397227287,
-0.04419276490807533,
-0.03286604583263397,
-0.012847003526985645,
0.030034366995096207,
-0.01541176252067089,
-0.00338292820379138,
0.010183600708842278,
-0.03001115657389164,
-0.03644046187400818,
0.004148874431848526,
0.014761868864297867,
-0.009237772785127163,
-0.038738299161195755,
0.028363212943077087,
-0.01685081236064434,
-0.00039022628334350884,
0.011083006858825684,
0.00550088519230485,
-0.0014970762422308326,
-0.0010212613269686699,
-0.016502654179930687,
-0.00047762825852259994,
-0.004462215583771467,
0.03219294175505638,
-0.008059840649366379,
0.008001814596354961,
0.03883114084601402,
0.0035715133417397738,
-0.025508323684334755,
-0.005706877913326025,
-0.01859159953892231,
-0.015284104272723198,
-0.02351222187280655,
0.003832631278783083,
-0.011663269251585007,
0.02478879876434803,
-0.0366029366850853,
0.0002522326831240207,
-0.0010800128802657127,
-0.011297703720629215,
0.005112109240144491,
-0.031102050095796585,
0.022351697087287903,
-0.04124503210186958,
0.014146790839731693,
-0.04008450731635094,
-0.015295709483325481,
0.029454106464982033,
0.01813899353146553,
-0.005837437231093645,
-0.008048235438764095,
-0.024231746792793274,
0.026552794501185417,
-0.014030738733708858,
-0.012115873396396637,
-0.04625849798321724,
0.03114847093820572,
-0.042057398706674576,
0.03265715390443802,
-0.0453764982521534,
-0.004656603559851646,
-0.021504513919353485,
0.026506373658776283,
-0.0035773159470409155,
0.00001425722166459309,
0.028084687888622284,
0.022015145048499107,
0.006690422538667917,
0.010305455885827541,
0.006986355874687433,
0.006208804901689291,
-0.04314829036593437,
-0.006829685065895319,
0.01737304776906967,
-0.03068426065146923,
-0.031171681359410286,
0.00009936989226844162,
-0.017140943557024002,
0.005782312247902155,
0.028386423364281654,
-0.003200145671144128,
-0.007758104708045721,
0.020146701484918594,
0.04064156115055084,
0.00834997184574604,
0.0035076846834272146,
0.002016410930082202,
0.009916679933667183,
0.033214204013347626,
-0.02736516296863556,
0.00757822347804904,
-0.007955393753945827,
0.0024545087944716215,
0.010363481938838959,
0.0147386584430933,
-0.001853937515988946,
0.044401656836271286,
0.018997782841324806,
-0.026251059025526047,
-0.03725282847881317,
-0.001650845748372376,
0.00930160190910101,
0.003237862605601549,
-0.009353825822472572,
-0.029152369126677513,
-0.008686523884534836,
0.011837347410619259,
0.0037600987125188112,
-0.011373138055205345,
0.03808840736746788,
-0.00598830496892333,
-0.004038624465465546,
0.026668846607208252,
-0.010932138189673424,
-0.0006825333111919463,
0.019682491198182106,
-0.044332027435302734,
0.01760515384376049,
-0.020204726606607437,
-0.03395694121718407,
-0.005132418591529131,
0.04231271520256996,
-0.01679278537631035,
-0.02485843002796173,
0.0063074491918087006,
0.03514067456126213,
-0.010659415274858475,
0.011988215148448944,
-0.01008495595306158,
0.00986445602029562,
0.02123759314417839,
0.10026929527521133,
0.053616221994161606,
-0.05036675184965134,
0.020947463810443878,
-0.013264792039990425,
-0.01935754530131817,
0.009603338316082954,
-0.0003323814016766846,
0.00736932922154665,
-0.027713319286704063,
0.02615821734070778,
0.005184642039239407,
0.08300069719552994,
-0.010862506926059723,
0.00761303910985589,
-0.0044709197245538235,
0.0034177438355982304,
-0.003765901317819953,
-0.0008515346562489867,
-0.02864173799753189,
-0.04437844827771187,
0.026784900575876236,
-0.02155093476176262,
0.008640103042125702,
-0.027481215074658394,
-0.06406094133853912,
-0.017500706017017365,
0.01557423546910286,
0.003339408664032817,
-0.010479534044861794,
0.01828986220061779,
-0.02471916750073433,
0.006487330421805382,
0.003034770954400301,
-0.0005918673705309629,
-0.03272678330540657,
-0.000458407070254907,
0.009115917608141899,
-0.0010829141829162836,
0.03288925811648369,
-0.03476930782198906,
0.002059930469840765,
0.013589738868176937,
0.014599394984543324,
0.05965094640851021,
-0.01005014032125473,
0.010694230906665325,
-0.02834000252187252,
-0.03748493269085884,
-0.03667256608605385,
-0.017431074753403664,
0.012754161842167377,
-0.007363526616245508,
-0.0005548756453208625,
-0.03409620374441147,
-0.02019312232732773,
-0.009968903847038746,
0.004331656731665134,
0.008651708252727985,
0.03920251131057739,
0.005170135758817196,
-0.014761868864297867,
-0.033005308359861374,
0.03256431221961975,
0.013125529512763023,
-0.02244453877210617,
0.023489011451601982,
-0.004427399951964617,
-0.03008078970015049,
0.057469163089990616,
0.014123580418527126,
0.03212331235408783,
0.0036121318116784096,
-0.009121720679104328,
0.024533482268452644,
0.006290041375905275,
-0.01737304776906967,
-0.0028258764650672674,
0.013241581618785858,
-0.03272678330540657,
-0.017570337280631065,
-0.03288925811648369,
0.01799973100423813,
-0.00952210184186697,
-0.01815059967339039,
0.005817127879709005,
0.011918583884835243,
0.035256728529930115,
0.021295620128512383,
0.014483342878520489,
-0.03135736659169197,
-0.035256728529930115,
-0.004859695211052895,
0.007177842315286398,
0.02676169015467167,
-0.027922213077545166,
-0.00470302440226078,
-0.037763457745313644,
0.011088808998465538,
0.017106126993894577,
-0.01497076265513897,
-0.002783807460218668,
-0.03778667002916336,
0.029895104467868805,
0.009957297705113888,
-0.0044244988821446896,
-0.04136108607053757,
-0.01671154983341694,
-0.0008442813996225595,
0.00546026648953557,
0.012905029579997063,
0.011204862035810947,
-0.03711356595158577,
-0.014692236669361591,
0.030637839809060097,
0.021423278376460075,
-0.002973843365907669,
0.017663178965449333,
-0.0007572420872747898,
-0.018696045503020287,
0.0005207852809689939,
-0.0019714406225830317,
0.005999910645186901,
0.03226257488131523,
0.016688339412212372,
-0.0006709281005896628,
-0.037972353398799896,
0.047210127115249634,
0.02252577617764473,
0.022723065689206123,
-0.016990074887871742,
-0.004874201957136393,
-0.019740518182516098,
0.012371188960969448,
-0.044633764773607254,
-0.0011721295304596424,
0.01050274446606636,
0.050738122314214706,
0.027179477736353874,
-0.07738375663757324,
0.009133325889706612,
-0.01890493929386139,
0.011019177734851837,
-0.01964767649769783,
0.0228971429169178,
-0.04892770200967789,
0.009429259225726128,
-0.02569400705397129,
-0.005602431017905474,
0.020761778578162193,
-0.00913912896066904,
0.006046331487596035,
-0.002579265274107456,
0.0007158984080888331,
-0.033005308359861374,
-0.030777104198932648,
-0.028131108731031418,
0.019844964146614075,
0.03179836645722389,
0.013021082617342472,
0.004732037894427776,
-0.035187095403671265,
0.04437844827771187,
-0.008210709318518639,
0.021945513784885406,
-0.022618617862462997,
0.020541278645396233,
-0.02933805249631405,
0.013473686762154102,
0.019705701619386673,
0.01844073086977005,
-0.06229694187641144,
0.011756110936403275,
0.02525300718843937,
0.0019163156393915415,
0.027318740263581276,
0.04370534420013428,
0.012800582684576511,
0.01686241663992405,
-0.02729552984237671,
0.010531757958233356,
0.013624554499983788,
-0.009081101976335049,
-0.00898826029151678,
0.03008078970015049,
-0.014634210616350174,
0.005027971230447292,
-0.023535432294011116,
-0.01813899353146553,
0.0010807382641360164,
-0.01989138498902321,
-0.01289342436939478,
0.030405735597014427,
-0.00519624724984169,
-0.04846349358558655,
-0.026947373524308205,
0.003278481075540185,
0.013125529512763023,
0.01232476718723774,
-0.011065598577260971,
0.04008450731635094,
0.03671898692846298,
-0.02977905236184597,
-0.0019641872495412827,
-0.012591687962412834,
-0.031171681359410286,
0.01851036213338375,
-0.05681926757097244,
-0.005596628412604332,
-0.00975420605391264,
-0.015829550102353096,
-0.030707471072673798,
0.03734567016363144,
0.043426819145679474,
-0.017117733135819435,
-0.02011188492178917,
-0.010183600708842278,
-0.010566573590040207,
0.016491049900650978,
-0.0035715133417397738,
-0.02720268815755844,
-0.004984451923519373,
0.01827825792133808,
-0.008413800969719887,
0.0004997507785446942,
-0.007984407246112823,
0.03667256608605385,
0.023001590743660927,
0.028897054493427277,
0.010131376795470715,
-0.004537649918347597,
0.01943878084421158,
0.015249288640916348,
0.009220365434885025,
-0.007996012456715107,
-0.03407299146056175,
0.009307404980063438,
-0.0049583399668335915,
0.00504247797653079,
0.0619719959795475,
-0.038204457610845566,
-0.006748448591679335,
0.0052310628816485405,
-0.040479086339473724,
-0.03883114084601402,
0.006464120000600815,
0.010734849609434605,
-0.0027533438988029957,
-0.034954991191625595,
0.06796029955148697,
-0.032912466675043106,
0.0010509997373446822,
0.006910922005772591,
0.00015322546823881567,
-0.0192647036164999,
0.04588712751865387,
-0.011164243333041668,
0.028525685891509056,
0.013937896117568016,
0.06150778755545616,
-0.007781315129250288,
-0.031775154173374176,
-0.01640981249511242,
-0.0031798365525901318,
-0.0009915229165926576,
0.012185504660010338,
0.04050229489803314,
0.009255181066691875,
0.04827781021595001,
-0.028223950415849686,
0.015423367731273174,
-0.02329172194004059,
-0.010624599643051624,
-0.010253231972455978,
-0.0019496807362884283,
-0.0012054946273565292,
0.02827037125825882,
0.027388373389840126,
0.02471916750073433,
0.004650800954550505,
-0.0003666531410999596,
-0.022189224138855934,
-0.00029448303394019604,
0.04354286938905716,
-0.003731085453182459,
-0.020889436826109886,
0.0367421992123127,
-0.021736619994044304,
0.008291945792734623,
-0.024742377921938896,
0.015701893717050552,
0.00042794333421625197,
0.04967043921351433,
0.04967043921351433,
-0.011761913076043129,
0.0295469481498003,
-0.021864276379346848,
-0.024881640449166298,
0.01197660993784666,
-0.01616610214114189,
0.05927957966923714,
-0.014669026248157024,
0.0018989078234881163,
-0.00842540618032217,
-0.011732900515198708,
-0.02192230336368084,
0.01410036999732256,
0.006702027749270201,
-0.004395485855638981,
0.01156462449580431,
-0.07134903222322464,
0.024603113532066345,
-0.009620745666325092,
-0.04481944814324379,
0.017442679032683372,
-0.0038819536566734314,
-0.02977905236184597,
0.003243665210902691,
0.019926201552152634,
0.0038181247655302286,
0.0011104766745120287,
0.007589828688651323,
0.030893156304955482,
0.00041126078576780856,
-0.00045441777911037207,
0.013926290906965733,
-0.004508636891841888,
0.00877356342971325,
-0.022119592875242233,
-0.00937123317271471,
-0.015295709483325481,
0.030962787568569183,
0.04823138937354088,
0.04152355715632439,
-0.020726963877677917,
-0.03569772467017174,
0.02193390764296055,
-0.07167398184537888,
-0.03695109114050865,
-0.03943461552262306,
0.04507476091384888,
0.03326062485575676,
-0.007984407246112823,
-0.019183466210961342,
0.02100548893213272,
0.020471647381782532,
-0.05148085579276085,
0.0008123669540509582,
0.05807263404130936,
-0.024371009320020676,
0.015817945823073387,
-0.002875198842957616,
0.04869559779763222,
0.03274999558925629,
-0.05078454315662384,
0.011297703720629215,
-0.033074941486120224,
-0.027550846338272095,
-0.011500795371830463,
-0.023396169766783714,
-0.06067220866680145,
0.03834372013807297,
0.009765811264514923,
0.016491049900650978,
0.009620745666325092,
0.04653702303767204,
0.013334423303604126,
-0.0279686339199543,
0.017268601804971695,
-0.0017161252908408642,
0.03794914484024048,
0.054544638842344284,
-0.003704973729327321,
-0.010380889289081097,
0.01519126258790493,
0.018034547567367554,
-0.04423918575048447,
0.0110714016482234,
-0.0001255723473150283,
0.07028134912252426,
0.022572197020053864,
-0.020123491063714027,
-0.018405914306640625,
0.006226212717592716,
-0.007125618867576122,
0.033283837139606476,
-0.03467646613717079,
0.005239767022430897,
-0.03061462938785553,
0.021655382588505745,
-0.0011844601249322295,
-0.0014912736369296908,
0.04166281968355179,
0.009435062296688557,
-0.033005308359861374,
-0.01205784734338522,
0.02743479423224926,
0.03922571986913681,
0.0036527500487864017,
-0.012742556631565094,
0.015040394850075245,
-0.037763457745313644,
0.04635133966803551,
0.006835487671196461,
0.0322161540389061,
0.010450520552694798,
-0.0053703258745372295,
0.004615985322743654,
0.01618931256234646,
0.012336373329162598,
-0.010195205919444561,
0.008663313463330269,
0.01251045148819685,
-0.015492998994886875,
0.011953399516642094,
-0.0026880642399191856,
-0.019670886918902397,
-0.01307910867035389,
0.016757970675826073,
0.0039747958071529865,
0.011953399516642094,
-0.017361443489789963,
0.011616847477853298,
-0.010386692360043526,
-0.011436966247856617,
0.01806936226785183,
-0.01654907502233982,
0.03456041216850281,
-0.009440864436328411,
-0.012777372263371944,
0.028966685757040977,
-0.03657972440123558,
-0.010700033977627754,
0.00477845873683691,
-0.014216422103345394,
-0.004328755661845207,
-0.027875792235136032,
0.0029912511818110943,
0.0005983953014947474,
-0.02810789830982685,
0.006342265289276838,
-0.019287914037704468,
-0.01671154983341694,
0.017477495595812798,
-0.022572197020053864,
-0.02252577617764473,
-0.007079198025166988,
0.019937807694077492,
-0.022316882386803627,
-0.011570426635444164,
0.028989896178245544,
0.036765407770872116,
-0.023860378190875053,
-0.0027533438988029957,
-0.006597580388188362,
-0.017140943557024002,
0.02994152531027794,
0.012231925502419472,
-0.037833090871572495,
0.014901131391525269,
-0.010276442393660545,
-0.006585975177586079,
0.008338366635143757,
-0.02615821734070778,
0.012150689028203487,
0.01314873993396759,
-0.01152980886399746,
-0.038575828075408936,
-0.011158441193401814,
0.006464120000600815,
-0.024997692555189133,
-0.009179746732115746,
-0.00922616757452488,
-0.0017799540655687451,
-0.0008145429892465472,
-0.02910594828426838,
0.0028635936323553324,
0.02131883054971695,
0.0036324409302324057,
-0.01001532468944788,
0.015365340746939182,
0.019102228805422783,
0.004334558267146349,
0.045701444149017334,
-0.020367201417684555,
0.004816175904124975,
-0.004650800954550505,
-0.01126869022846222,
-0.015133236534893513,
0.051063068211078644,
-0.019589649513363838,
-0.024324588477611542,
0.0006052859243936837,
0.00030917092226445675,
-0.019543228670954704,
0.013740607537329197,
-0.008837392553687096,
0.024394219741225243,
0.016815995797514915,
-0.006916724611073732,
0.042289502918720245,
0.034885358065366745,
0.00602892367169261,
0.017245391383767128,
0.0414075069129467,
-0.03342309966683388,
0.014053949154913425,
0.00248352182097733,
-0.014251237735152245,
0.00606373930349946,
0.002743189223110676,
-0.011007572524249554,
-0.0013360535958781838,
-0.037067145109176636,
0.0026300381869077682,
0.04119861125946045,
0.017198968678712845,
-0.003606329206377268,
0.001840881654061377,
-0.0033539151772856712,
0.00899406336247921,
-0.02743479423224926,
-0.036394041031599045,
-0.005257174838334322,
-0.029430896043777466,
0.010781270451843739,
-0.027040215209126472,
-0.004337459336966276,
0.0024588608648627996,
-0.010351876728236675,
-0.0023602161090821028,
-0.008454419672489166,
0.05013464763760567,
-0.013125529512763023,
-0.002387778600677848,
0.0057097794488072395,
0.015933997929096222,
-0.022502565756440163,
0.03008078970015049,
-0.03228578343987465,
-0.007705881260335445,
0.03920251131057739,
0.005297793075442314,
-0.004775557201355696,
0.04396066069602966,
-0.028386423364281654,
-0.0020251148380339146,
-0.0051411222666502,
0.0139495013281703,
-0.003301691496744752,
0.03530314937233925,
-0.03611551597714424,
0.022839117795228958,
0.00317403394728899,
0.014785079285502434,
-0.0009400246781297028,
0.00022068094403948635,
-0.025810059159994125,
0.0026126301381736994,
-0.0113789401948452,
-0.002247065072879195,
0.0027460905257612467,
-0.0015130335232242942,
-0.0198797807097435,
0.01541176252067089,
-0.017558731138706207,
-0.01882370375096798,
-0.009046286344528198,
0.03265715390443802,
0.007114013656973839,
0.025972532108426094,
0.034049782902002335,
0.004491229075938463,
-0.018568387255072594,
-0.011396348476409912,
-0.03031289391219616,
-0.013485291972756386,
-0.06703188270330429,
0.005213655065745115,
0.0024820712860673666,
0.04013092815876007,
0.02659921534359455,
0.024626323953270912,
0.02041362226009369,
0.0024371009785681963,
-0.00800761766731739,
-0.006702027749270201,
0.03657972440123558,
-0.02478879876434803,
0.011686479672789574,
-0.012858608737587929,
-0.021121541038155556,
-0.014436922036111355,
-0.021202778443694115,
0.009986311197280884,
-0.04804570600390434,
-0.03725282847881317,
0.03521030768752098,
0.027852581813931465,
0.00986445602029562,
-0.004575367085635662,
-0.007624644320458174,
0.010769665241241455,
0.02864173799753189,
0.009115917608141899,
0.012614898383617401,
0.011465979740023613,
-0.014181606471538544,
0.019844964146614075,
0.00516143161803484,
0.017198968678712845,
0.02917557954788208,
0.006899316795170307,
0.0017915592761710286,
-0.014761868864297867,
0.016386602073907852,
-0.004070539027452469,
-0.01477347407490015,
0.00993989035487175,
-0.036695778369903564,
0.055983688682317734,
-0.01805775798857212,
-0.024881640449166298,
-0.0022688249591737986,
-0.012881819158792496,
0.026018954813480377,
-0.02759726718068123,
-0.007131421472877264,
0.02063412219285965,
-0.039875615388154984,
0.002070085145533085,
0.0003563172067515552,
0.006290041375905275,
-0.024069273844361305,
0.01579473540186882,
-0.016293760389089584,
-0.028479265049099922,
-0.015817945823073387,
0.007288092281669378,
0.026715269312262535,
-0.013763817958533764,
-0.012173899449408054,
-0.035395991057157516,
0.009435062296688557,
0.04539971053600311,
-0.04574786499142647,
-0.01413518562912941,
0.003467066213488579,
0.02840963378548622,
-0.01784886233508587,
0.004691419191658497,
-0.008210709318518639,
0.03151983767747879,
0.02425495721399784,
-0.01564386673271656,
0.00598830496892333,
0.005280385259538889,
0.029222000390291214,
0.04419276490807533,
-0.012347978539764881,
0.008674918673932552,
0.00343805318698287,
-0.034885358065366745,
-0.0366029366850853,
-0.018684441223740578,
-0.020053859800100327,
0.029616579413414,
-0.008703932166099548,
0.01032286323606968,
0.03219294175505638,
-0.021562540903687477,
0.0035018818452954292,
-0.025670796632766724,
-0.033283837139606476,
0.011204862035810947,
0.015086815692484379,
0.0031827378552407026,
-0.016653522849082947,
-0.004418696276843548,
0.00785674899816513,
-0.010340271517634392,
0.006731040775775909,
0.010659415274858475,
-0.015434972941875458,
0.003092797240242362,
0.04746544361114502,
-0.017431074753403664,
0.012359583750367165,
0.008640103042125702,
0.043798185884952545,
-0.012986266054213047,
-0.019183466210961342,
0.01410036999732256,
-0.02230527624487877,
-0.04177887365221977,
-0.03024326264858246,
0.012336373329162598,
0.0011967906029894948,
-0.011953399516642094,
0.001109751290641725,
0.016874022781848907,
-0.030521787703037262,
0.022850722074508667,
-0.013891475275158882,
0.029871894046664238,
-0.016293760389089584,
0.004061834886670113,
-0.026088586077094078,
0.01024742890149355,
0.003725282847881317,
0.0039022627752274275,
0.007537605240941048,
0.015342130325734615,
-0.011355729773640633,
0.021817855536937714,
0.02130722627043724,
-0.001793009927496314,
0.019160255789756775,
-0.013415660709142685,
-0.01827825792133808,
0.04686196893453598,
-0.024765588343143463,
0.015063605271279812,
0.014193211682140827,
-0.021295620128512383,
-0.04642096906900406,
0.006040528882294893,
-0.00602892367169261,
0.0031044024508446455,
-0.005149826407432556,
-0.011669071391224861,
-0.008251327089965343,
0.010108166374266148,
0.020541278645396233,
0.011059796437621117,
0.02404606342315674,
0.020448436960577965,
-0.027875792235136032,
-0.0058722528629004955,
-0.04033982381224632,
0.017129337415099144,
0.02683132141828537,
0.015539419837296009,
0.010021126829087734,
0.003768802620470524,
-0.02518337592482567,
-0.021272409707307816,
-0.028177529573440552,
0.0110714016482234,
-0.013473686762154102,
0.020738568156957626,
-0.0036382435355335474,
-0.01881209760904312,
0.0051411222666502,
-0.0002600299776531756,
-0.04180208221077919,
-0.011373138055205345,
0.022282065823674202,
0.01927630789577961,
0.039713140577077866,
0.051434434950351715,
-0.01943878084421158,
-0.01194179430603981,
-0.020599305629730225,
-0.015353735536336899,
-0.008088854141533375,
-0.02101709507405758,
0.02690095268189907,
-0.015968814492225647,
-0.010665218345820904,
0.03507104143500328,
0.024626323953270912,
-0.009011470712721348,
-0.018394310027360916,
-0.014402106404304504,
-0.00606373930349946,
0.020285964012145996,
-0.04635133966803551,
0.023790746927261353,
-0.02153933048248291,
-0.006214607506990433,
-0.012382794171571732,
0.010752256959676743,
-0.023755932226777077,
0.024510271847248077,
0.0011416657362133265,
-0.017872072756290436,
-0.00659177778288722,
0.0030492774676531553,
0.0001734439720166847,
0.01753552071750164,
-0.026483163237571716,
0.027643688023090363,
0.016386602073907852,
0.022583801299333572,
-0.004244617652148008,
0.06647483259439468,
-0.015551025047898293,
0.011587834917008877,
0.053476959466934204,
-0.00022267558961175382,
-0.004148874431848526,
0.01827825792133808,
0.03859903663396835,
-0.009324812330305576,
0.03031289391219616,
0.025810059159994125,
-0.012150689028203487,
0.004351966083049774,
-0.008106261491775513,
-0.015910787507891655,
-0.015330525115132332,
0.010102363303303719,
0.07594470679759979,
-0.03876151144504547,
-0.006893514189869165,
-0.0021310127340257168,
0.0035337964072823524,
0.004642096813768148,
-0.017048101872205734,
-0.027388373389840126,
0.010102363303303719,
0.00060419796500355,
0.0009516298887319863,
0.043125081807374954,
0.031078839674592018,
0.01522607821971178,
0.013995922170579433,
-0.03546562045812607,
0.0007206130539998412,
0.006295843981206417,
-0.017198968678712845,
0.004044427070766687,
-0.018347889184951782,
0.02175983041524887,
-0.026854531839489937,
0.006835487671196461,
0.017779231071472168,
-0.05110948905348778,
0.0009639604832045734,
-0.009580127894878387,
-0.014993973076343536,
-0.022769486531615257,
0.0033132967073470354,
0.014529763720929623,
0.009771614335477352,
-0.012649714015424252,
0.01292824000120163,
0.02984868362545967,
-0.017663178965449333,
-0.025044113397598267,
0.016990074887871742,
0.0021498710848391056,
0.022467749193310738,
0.020123491063714027,
0.002206446835771203,
-0.020239543169736862,
-0.010752256959676743,
-0.008431208319962025,
-0.02850247547030449,
0.014831500127911568,
0.012719346210360527,
0.0034090399276465178,
-0.018011337146162987,
0.01904420368373394,
0.020065464079380035,
0.02351222187280655,
0.011622650548815727,
-0.01209266297519207,
0.030034366995096207,
0.0015507505740970373,
-0.0013948051491752267,
-0.0474422313272953,
-0.010235823690891266,
-0.018417520448565483,
0.02222403883934021,
-0.0008268735255114734,
0.030893156304955482
] | 2025-01-21 | 1 | 39832454 | [
"B cells",
"mature B cells",
"dysregulated B cell activation",
"B cell activating factor",
"alternative B cell depletion therapies",
"plasma cells",
"peripheral blood mononuclear cells",
"SLE therapy",
"SLE patients",
"SLE",
"autoreactive B-cell survival",
"BAFF specific belimumab",
"BAFF CAR-T cells",
"specific rituximab antibodies",
"patient PBMCs",
"mouse model",
"humanized mouse",
"murine CD8",
"immunocompromised mice",
"Systemic lupus erythematosus",
"overexpression enhances",
"BAFF",
"PBMCs",
"autoantibody production",
"TACI",
"BCMA",
"culture",
"BAFFr",
"co",
"-"
] | [
"Autoimmune",
"BAFF",
"CAR-T cells",
"Cytotoxicity",
"SLE"
] | 0 | 10.1016/j.jaut.2025.103369 | [
"Uppin",
"Gibbons",
"Troje",
"Feinberg",
"Webber",
"Moriarity",
"Parameswaran"
] | [
"Division of Haematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.",
"Luminary Therapeutics, Minneapolis, MN, USA.",
"Luminary Therapeutics, Minneapolis, MN, USA.",
"Division of Haematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA.",
"Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.",
"Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.",
"Division of Haematology/Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, Case Western Reserve University, Cleveland, OH, USA; Pediatric Haematology and Oncology, The Angie Fowler Adolescent & Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA; The Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address: [email protected]."
] | [
"39832454"
] | [] | 6.800169 | 5.149509 |
39831708 | 14 | Generation of Human Chimeric Antigen Receptor Regulatory T Cells. | Chimeric antigen receptor (CAR) T-cell therapy has reshaped the face of cancer treatment, leading to record remission rates in previously incurable hematological cancers. These successes have spurred interest in adapting the CAR platform to a small yet pivotal subset of CD4 | [
0.03502711281180382,
-0.004577272105962038,
0.047708116471767426,
0.07299888134002686,
-0.03495587408542633,
-0.03322232887148857,
-0.010454703122377396,
0.03711686655879021,
0.00656609982252121,
0.003090103855356574,
-0.006815445143729448,
-0.019401459023356438,
-0.030752619728446007,
0.021550580859184265,
0.015946242958307266,
-0.026288146153092384,
0.06255011260509491,
-0.013927730731666088,
0.032794877886772156,
0.04500093683600426,
0.00656609982252121,
-0.007314136251807213,
0.003309765364974737,
0.010051000863313675,
-0.016302449628710747,
0.0009706666460260749,
-0.010211294516921043,
-0.012787865474820137,
-0.008911135606467724,
-0.025100786238908768,
0.021609948948025703,
-0.03374476730823517,
-0.03659442812204361,
-0.00936233252286911,
-0.008091856725513935,
0.030206434428691864,
0.01340529229491949,
0.001193296629935503,
-0.034528423100709915,
-0.007064790930598974,
0.0249345563352108,
0.018712790682911873,
0.02448335848748684,
0.09992820024490356,
-0.041296374052762985,
0.013429039157927036,
-0.008097793906927109,
-0.03018268570303917,
-0.018558433279395103,
0.005070026498287916,
-0.0246733371168375,
0.021716810762882233,
-0.0315600223839283,
0.02787920832633972,
-0.04640202224254608,
0.03659442812204361,
-0.01623120903968811,
0.026644354686141014,
0.010686238296329975,
0.0010619449894875288,
0.0193302184343338,
-0.000777720648329705,
0.01801224797964096,
-0.013345924206078053,
-0.07613351196050644,
0.02066006138920784,
-0.06069783493876457,
-0.008246214129030704,
0.008845830336213112,
0.02407965622842312,
0.001957659376785159,
-0.007996868342161179,
0.001804786967113614,
-0.010122242383658886,
0.04255497455596924,
0.008768652565777302,
-0.012253553606569767,
0.04466847702860832,
-0.014652020297944546,
0.005444044712930918,
0.025623224675655365,
-0.006150523666292429,
0.009374205954372883,
-0.0686768889427185,
-0.031417541205883026,
-0.01776290312409401,
0.0063820588402450085,
-0.022001776844263077,
-0.024649590253829956,
-0.015233826823532581,
0.0277367252856493,
0.012942221947014332,
-0.0463070310652256,
0.016349945217370987,
0.0013298429548740387,
0.010591249912977219,
-0.04509592428803444,
-0.056708306074142456,
0.027522999793291092,
0.058845553547143936,
0.06354749947786331,
0.008335266262292862,
-0.021040016785264015,
-0.028995325788855553,
0.015518792904913425,
0.022227374836802483,
-0.034172214567661285,
0.009647298604249954,
0.02203739807009697,
-0.018700916320085526,
0.06112528219819069,
-0.05110396817326546,
-0.011992334388196468,
0.04687696695327759,
-0.026074420660734177,
-0.04331488534808159,
-0.007314136251807213,
-0.006560163106769323,
-0.007806890644133091,
0.02336724102497101,
-0.01460452564060688,
0.0356207937002182,
0.02605067379772663,
-0.05062902346253395,
-0.0029491048771888018,
-0.02920905128121376,
0.039515335112810135,
-0.023343494161963463,
-0.01340529229491949,
-0.04982161894440651,
0.008062172681093216,
0.006993549410253763,
0.025623224675655365,
-0.03718810901045799,
-0.03455217182636261,
-0.013262809254229069,
-0.01715734973549843,
-0.046948205679655075,
-0.04920418933033943,
-0.023794690147042274,
0.01648055389523506,
-0.01984078250825405,
-0.02733302302658558,
-0.014925112947821617,
-0.022773561999201775,
-0.04967913404107094,
-0.013951477594673634,
0.028164174407720566,
0.013619016855955124,
0.008026552386581898,
-0.014093960635364056,
0.03652318939566612,
0.05509349703788757,
-0.0007343078614212573,
-0.008923009037971497,
-0.011339286342263222,
-0.01017567329108715,
0.022975413128733635,
-0.017062360420823097,
-0.05637584254145622,
-0.032343681901693344,
0.00461882958188653,
-0.04010901600122452,
-0.034575916826725006,
-0.0008964566513895988,
-0.02457834780216217,
-0.016207462176680565,
0.029351534321904182,
-0.06525729596614838,
0.010816847905516624,
-0.02533825859427452,
-0.051531415432691574,
-0.04473971948027611,
-0.0004259653214830905,
-0.05499850586056709,
0.006987612694501877,
0.044193532317876816,
0.03129880502820015,
-0.050201572477817535,
-0.025172028690576553,
0.022429225966334343,
0.01836845651268959,
0.04015650972723961,
-0.01914023980498314,
-0.03547831252217293,
0.01180829294025898,
-0.029399028047919273,
0.004601019434630871,
-0.0391828753054142,
-0.017430441454052925,
-0.013013463467359543,
0.01827346719801426,
0.060887809842824936,
0.01700299233198166,
0.000623734958935529,
0.0048088072799146175,
0.05267127975821495,
0.021443719044327736,
-0.011060256510972977,
-0.017466062679886818,
-0.016516175121068954,
-0.008667727001011372,
-0.047708116471767426,
-0.0018077553249895573,
-0.02854412980377674,
-0.026905573904514313,
-0.018344709649682045,
-0.0045179040171206,
-0.021301234140992165,
0.009012061171233654,
0.020185116678476334,
-0.022524215281009674,
0.0017543240683153272,
0.028021691367030144,
-0.034219708293676376,
-0.011742988601326942,
-0.006399869453161955,
0.03284237161278725,
0.03576327860355377,
0.03058638796210289,
-0.011291791684925556,
-0.020719429478049278,
0.007017296273261309,
0.018902767449617386,
-0.03963407129049301,
0.0006014719838276505,
0.02172868512570858,
-0.041605088859796524,
-0.020090127363801003,
-0.014616399072110653,
-0.003579889889806509,
-0.01572064310312271,
0.012069512158632278,
-0.01578001119196415,
-0.026953067630529404,
-0.0037164362147450447,
0.04086892306804657,
-0.02025635913014412,
0.04395605996251106,
-0.018000375479459763,
-0.00290012639015913,
0.008418381214141846,
0.041700076311826706,
-0.017121728509664536,
-0.030871355906128883,
-0.02036322094500065,
-0.010781226679682732,
-0.07827075570821762,
0.008863640949130058,
-0.0017469031736254692,
-0.012823485769331455,
0.03196372464299202,
-0.017834143713116646,
0.01576813869178295,
0.018617801368236542,
0.045974571257829666,
0.03811424970626831,
-0.023937173187732697,
0.012217932380735874,
-0.03383975476026535,
0.00997382216155529,
-0.01608872599899769,
-0.031631264835596085,
-0.029090315103530884,
-0.04823055490851402,
-0.0049928477965295315,
0.010134115815162659,
0.015815632417798042,
0.031085079535841942,
0.013049084693193436,
0.03374476730823517,
0.034267205744981766,
0.04671073332428932,
-0.0008934882353059947,
-0.02733302302658558,
0.007432872429490089,
0.006862939801067114,
0.044146038591861725,
0.01923522911965847,
0.03994278237223625,
0.015459424816071987,
0.017679788172245026,
0.013488407246768475,
0.0063939327374100685,
-0.0054351394064724445,
-0.02259545773267746,
0.03329356759786606,
0.004164664540439844,
0.016349945217370987,
-0.03797176852822304,
-0.002812558552250266,
-0.006215828470885754,
-0.010822785086929798,
-0.04471597075462341,
-0.032129958271980286,
0.002478613518178463,
0.003630352672189474,
-0.011642063036561012,
-0.02733302302658558,
0.01427206490188837,
-0.020980648696422577,
0.0017825239337980747,
-0.015578160993754864,
-0.03642819821834564,
0.018617801368236542,
0.04250748082995415,
-0.012621634639799595,
-0.02911406196653843,
0.05666080862283707,
0.04697195440530777,
0.016777394339442253,
-0.01160644181072712,
0.016254955902695656,
0.015198205597698689,
0.00974228698760271,
0.01949644833803177,
0.018142858520150185,
-0.07451870292425156,
0.019722046330571175,
-0.04647326469421387,
-0.05552094429731369,
-0.010751543566584587,
-0.02574196085333824,
0.012942221947014332,
0.002585476031526923,
-0.015566287562251091,
0.024602094665169716,
-0.033079843968153,
0.03828047960996628,
-0.033056098967790604,
0.008685536682605743,
-0.037734296172857285,
0.06801196932792664,
-0.002346519846469164,
0.02301103249192238,
-0.01765604130923748,
-0.030467653647065163,
-0.07280890643596649,
0.03495587408542633,
0.021562453359365463,
0.029327787458896637,
0.027594242244958878,
-0.04253122955560684,
0.04906170815229416,
0.00440213643014431,
-0.007474429905414581,
0.00008654739940539002,
0.028021691367030144,
-0.0010240977862849832,
-0.010585312731564045,
0.0035680162254720926,
0.013357797637581825,
0.030776366591453552,
-0.008946755900979042,
-0.011339286342263222,
0.04583209007978439,
-0.02916155755519867,
-0.02880534902215004,
0.02295166440308094,
0.013714006170630455,
0.00536983460187912,
0.013559648767113686,
-0.024602094665169716,
0.020315727218985558,
0.051578909158706665,
0.06117277592420578,
-0.03288986533880234,
0.044288519769907,
-0.022726066410541534,
-0.03170250728726387,
-0.023592839017510414,
-0.018344709649682045,
0.009053618647158146,
0.008548990823328495,
-0.03018268570303917,
-0.00022485626686830074,
0.029541512951254845,
0.014497662894427776,
0.019686425104737282,
0.01060905959457159,
0.016053104773163795,
-0.01007474772632122,
-0.009166417643427849,
0.0007035107119008899,
-0.0341009721159935,
0.02443586476147175,
0.028472889214754105,
0.012550393119454384,
-0.10866717249155045,
0.010597186163067818,
-0.028971578925848007,
-0.02595568634569645,
0.024210266768932343,
0.008822083473205566,
-0.006957928650081158,
0.08729469031095505,
-0.016955498605966568,
0.07518362253904343,
0.03785303235054016,
0.03486088290810585,
-0.0218830406665802,
-0.03771054744720459,
-0.0012526646023616195,
-0.02814042754471302,
0.027404263615608215,
-0.019817035645246506,
0.049441661685705185,
0.00949294213205576,
0.0025498552713543177,
-0.04051271826028824,
-0.0036630050744861364,
0.016017483547329903,
0.04260246828198433,
0.019223354756832123,
-0.022726066410541534,
-0.025267016142606735,
-0.05894054099917412,
0.03248616307973862,
-0.024649590253829956,
0.042056284844875336,
0.031180068850517273,
-0.022963538765907288,
0.03963407129049301,
-0.01117305550724268,
0.004790996666997671,
0.012057638727128506,
0.02127748727798462,
0.02818792127072811,
-0.0009988663950935006,
-0.034219708293676376,
-0.00072354736039415,
0.044051047414541245,
0.028354153037071228,
-0.025931937620043755,
0.026383135467767715,
0.05499850586056709,
-0.01739482209086418,
0.008685536682605743,
-0.03191623091697693,
0.037235602736473083,
-0.04208003357052803,
0.02217988111078739,
0.032082460820674896,
-0.02681058458983898,
0.019935771822929382,
-0.016955498605966568,
-0.0008615779806859791,
0.009629487991333008,
-0.042459987103939056,
-0.036048244684934616,
-0.009522625245153904,
-0.036404453217983246,
-0.039824049919843674,
-0.00926140695810318,
-0.032533660531044006,
-0.020588818937540054,
0.02849663607776165,
-0.06188519299030304,
0.01226542703807354,
0.02681058458983898,
0.04576084762811661,
-0.014450169168412685,
0.008347139693796635,
-0.012502898462116718,
0.020956899970769882,
0.03592950850725174,
0.04977412149310112,
-0.01838032901287079,
-0.01046064030379057,
-0.01116711925715208,
0.03186873719096184,
0.0013001590268686414,
-0.014568905346095562,
0.013690258376300335,
-0.01740669459104538,
0.02911406196653843,
0.015542539767920971,
0.009475131519138813,
0.012906600721180439,
-0.01750168390572071,
-0.005838841665536165,
-0.02920905128121376,
-0.01214075367897749,
0.02076692320406437,
0.020470082759857178,
-0.00247564516030252,
-0.03996653109788895,
-0.02911406196653843,
-0.010953394696116447,
0.021229993551969528,
0.011315539479255676,
0.010413145646452904,
0.000023457312636310235,
-0.01043095625936985,
-0.017371073365211487,
-0.00118290726095438,
0.015910621732473373,
-0.005236256867647171,
-0.021752431988716125,
0.01089402660727501,
-0.01027659885585308,
0.03704562783241272,
-0.013987098820507526,
0.037639304995536804,
0.050249066203832626,
0.040940165519714355,
0.011547073721885681,
0.04929918050765991,
-0.01607685163617134,
0.00017049744201358408,
-0.029399028047919273,
-0.0017454188782721758,
0.018605928868055344,
-0.015839379280805588,
-0.027974197641015053,
-0.04407479614019394,
-0.05347868427634239,
-0.029707742854952812,
0.005604338366538286,
0.007266642060130835,
-0.02894783206284046,
0.0051798573695123196,
0.008459938690066338,
0.00867366325110197,
0.03711686655879021,
-0.014177076518535614,
-0.016611164435744286,
-0.040987659245729446,
-0.04155759513378143,
-0.02681058458983898,
0.004244811367243528,
-0.01633807085454464,
-0.0034403749741613865,
0.042008791118860245,
-0.023842185735702515,
-0.020588818937540054,
-0.06122027337551117,
0.05005909129977226,
-0.013785247690975666,
-0.023580966517329216,
0.004066707566380501,
0.007141969166696072,
-0.0035442691296339035,
-0.01739482209086418,
0.0010656553786247969,
0.00030277675250545144,
-0.012152628041803837,
-0.044502247124910355,
0.03899289667606354,
0.0009439510758966208,
0.020671933889389038,
-0.01739482209086418,
0.008186846040189266,
-0.010062874294817448,
0.030063951388001442,
-0.03543081507086754,
-0.003627384314313531,
-0.0030574514530599117,
-0.009041745215654373,
-0.011137435212731361,
-0.009920391254127026,
-0.02443586476147175,
0.011125561781227589,
-0.021823672577738762,
-0.02977898344397545,
0.02768923155963421,
0.0013127747224643826,
-0.0038114250637590885,
-0.028520382940769196,
-0.0032741446048021317,
0.006672962103039026,
0.003413659520447254,
0.007593166083097458,
-0.022880423814058304,
0.03424345701932907,
0.002751706400886178,
0.0003200305800419301,
0.027617989107966423,
0.0005421039531938732,
0.043742336332798004,
-0.01838032901287079,
-0.03367352485656738,
-0.006049598101526499,
0.04293493181467056,
0.0030307359993457794,
0.004232937935739756,
-0.06611219793558121,
-0.012586014345288277,
0.007070727646350861,
0.0013877267483621836,
0.05894054099917412,
0.027522999793291092,
0.0432673916220665,
0.0345996655523777,
-0.05860808119177818,
0.018249720335006714,
0.00816309917718172,
-0.006245512515306473,
-0.03873167559504509,
-0.008798336610198021,
-0.002207005163654685,
-0.004927542991936207,
0.01313219964504242,
-0.036000750958919525,
-0.028781602159142494,
0.011357096955180168,
-0.02498205006122589,
-0.021194372326135635,
-0.007682218216359615,
-0.012609761208295822,
0.04576084762811661,
0.03298485651612282,
-0.014592652209103107,
0.01663491129875183,
0.021289361640810966,
0.012016081251204014,
-0.0014315106673166156,
-0.02529076486825943,
0.004188411869108677,
-0.025219522416591644,
-0.022215502336621284,
0.00396875012665987,
-0.030515147373080254,
0.007907816208899021,
-0.030562641099095345,
-0.03144128620624542,
-0.01796475425362587,
0.013797121122479439,
0.02397279441356659,
-0.005387645214796066,
-0.0023005097173154354,
0.005346087738871574,
0.0013001590268686414,
0.037425581365823746,
-0.020838163793087006,
-0.03932535648345947,
0.035953253507614136,
0.005752758122980595,
0.00015092456305865198,
0.023747196421027184,
-0.0017157349502667785,
-0.02152683399617672,
0.00956418365240097,
0.0007046238170005381,
0.02733302302658558,
-0.016872383654117584,
-0.023984668776392937,
-0.013393418863415718,
0.013856489211320877,
-0.003039641072973609,
0.007361630909144878,
-0.019342090934515,
0.00020426299306564033,
-0.015518792904913425,
0.01196265034377575,
-0.024234013631939888,
0.0014174107927829027,
0.0050759632140398026,
0.05328870937228203,
0.06274009495973587,
-0.00849555991590023,
0.027356769889593124,
-0.008299645036458969,
-0.022429225966334343,
-0.014236444607377052,
-0.003962813410907984,
0.01147583220154047,
0.008252150379121304,
-0.002558760344982147,
0.02457834780216217,
0.08881451189517975,
0.024388371035456657,
0.037330593913793564,
-0.038399215787649155,
-0.025528235360980034,
0.013903983868658543,
0.00452977791428566,
-0.010425019077956676,
-0.021348729729652405,
-0.000503885792568326,
-0.0037520569749176502,
0.015150710940361023,
-0.03343605250120163,
-0.04424102604389191,
0.01224167924374342,
-0.007017296273261309,
0.008798336610198021,
0.02443586476147175,
0.013464660383760929,
-0.003410691162571311,
-0.002535013249143958,
-0.035145848989486694,
-0.03374476730823517,
-0.018689043819904327,
0.021194372326135635,
0.014853871427476406,
0.002762095769867301,
-0.0048295860178768635,
0.0027665484230965376,
0.006750140339136124,
0.02609816938638687,
0.013761499896645546,
0.034837137907743454,
-0.014652020297944546,
0.027617989107966423,
-0.006441426929086447,
-0.003032220061868429,
-0.012692876160144806,
0.00999756995588541,
0.023794690147042274,
0.0223936066031456,
-0.0033394494093954563,
-0.030443904921412468,
-0.01493698637932539,
-0.011665809899568558,
0.011131498031318188,
-0.010959330946207047,
0.048729248344898224,
-0.01729983277618885,
0.03616698086261749,
-0.0038618878461420536,
0.012716623954474926,
-0.020624440163373947,
0.0045179040171206,
0.00979571882635355,
0.045309651643037796,
-0.025005796924233437,
0.050106585025787354,
-0.02635938860476017,
-0.000684587168507278,
-0.011469895951449871,
-0.027499252930283546,
-0.018867148086428642,
-0.001545051927678287,
-0.0027799061499536037,
0.029351534321904182,
-0.02193053625524044,
-0.025623224675655365,
-0.0012749276356771588,
0.00450306199491024,
0.02768923155963421,
-0.04820680990815163,
0.004351673647761345,
0.016349945217370987,
-0.033554788678884506,
0.03972905874252319,
0.027475506067276,
0.008186846040189266,
-0.01213481742888689,
-0.03246241807937622,
0.00997382216155529,
0.008281834423542023,
0.003383975476026535,
-0.01912836730480194,
0.0008348623523488641,
-0.02605067379772663,
-0.020636312663555145,
-0.003980623558163643,
-0.0396815650165081,
-0.023450355976819992,
-0.016017483547329903,
-0.0023747195955365896,
-0.0035205218009650707,
0.012158564291894436,
-0.005886336322873831,
0.003924224060028791,
0.020541325211524963,
0.001534662558697164,
-0.00990258064121008,
-0.003265239531174302,
-0.0315362773835659,
-0.004687102977186441,
-0.002163963159546256,
-0.02194240875542164,
-0.021289361640810966,
0.014628272503614426,
-0.0032889866270124912,
0.038802918046712875,
-0.030871355906128883,
0.009249532595276833,
0.01699111983180046,
-0.005218446254730225,
-0.013155946508049965,
0.00910704955458641,
-0.016266830265522003,
-0.017442315816879272,
-0.009249532595276833,
0.0021684158127754927,
-0.02250046841800213,
-0.00035528032458387315,
-0.0463070310652256,
0.014853871427476406,
-0.01786976493895054,
0.0033394494093954563,
-0.016124345362186432,
0.018760284408926964,
0.046283286064863205,
-0.07499364763498306,
-0.0030811987817287445,
0.002349488204345107,
-0.006815445143729448,
-0.014022719115018845,
0.029755236580967903,
-0.021051889285445213,
-0.007919689640402794,
0.0090358080342412,
-0.005013627000153065,
0.008186846040189266,
-0.02961275354027748,
0.02350972406566143,
0.007729712408035994,
0.02355721779167652,
-0.015696896240115166,
-0.014521410688757896,
-0.033554788678884506,
-0.025670718401670456,
0.042008791118860245,
0.015661275014281273,
0.0020660061854869127,
-0.007498177234083414,
0.05200636014342308,
-0.020220737904310226,
0.018392203375697136,
-0.03312733769416809,
0.018499065190553665,
-0.03103758580982685,
-0.019199607893824577,
0.04519091546535492,
0.032343681901693344,
-0.008750841952860355,
0.03227243945002556,
-0.015198205597698689,
-0.020137622952461243,
0.02880534902215004,
-0.01607685163617134,
-0.03151252865791321,
0.03089510276913643,
0.0001290326181333512,
-0.003998434171080589,
0.006583909969776869,
0.006530479062348604,
-0.007593166083097458,
-0.01453328412026167,
-0.019674552604556084,
0.01366651151329279,
0.012117006815969944,
-0.0027799061499536037,
0.0396815650165081,
-0.01770353503525257,
-0.03573952987790108,
0.0010381977772340178,
-0.009142670780420303,
-0.02787920832633972,
-0.008715220727026463,
0.013903983868658543,
0.010757479816675186,
0.01678926683962345,
-0.031085079535841942,
0.0671570673584938,
0.05214884132146835,
-0.008121540769934654,
-0.00964136142283678,
-0.014770756475627422,
-0.027214286848902702,
0.03628571704030037,
-0.03196372464299202,
0.00900612398982048,
-0.016504300758242607,
0.021704938262701035,
-0.03072887286543846,
0.017572924494743347,
-0.006655151955783367,
0.022061144933104515,
-0.005729011259973049,
0.00046566769015043974,
0.029232798144221306,
0.008952693082392216,
-0.030420158058404922,
-0.02662060782313347,
-0.0124672781676054,
-0.013440913520753384,
-0.030562641099095345,
-0.009914454072713852,
-0.022821055725216866,
0.02264295145869255,
0.0165399219840765,
0.004179506562650204,
-0.020529450848698616,
0.005055184476077557,
0.0020571008790284395,
-0.008364950306713581,
-0.0048622386530041695,
-0.0032266501802951097,
-0.04678197577595711,
0.007795017212629318,
-0.0018908705096691847,
-0.025979433208703995,
0.05262378603219986,
-0.042246263474226,
0.0041320123709738255,
-0.04086892306804657,
-0.03072887286543846,
-0.024388371035456657,
0.04901421442627907,
-0.0023791722487658262,
0.004155759233981371,
-0.01766791380941868,
0.018950263038277626,
-0.01009849552065134,
0.04424102604389191,
-0.022025523707270622,
-0.013702131807804108,
0.009291090071201324,
0.018807779997587204,
0.0007955310866236687,
0.006251449231058359,
-0.012122943997383118,
0.05205385386943817,
-0.02183554694056511,
0.0277367252856493,
-0.024210266768932343,
0.019959518685936928,
-0.0032800815533846617,
0.0087745888158679,
0.015020101331174374,
0.037829283624887466,
-0.027404263615608215,
0.0376630537211895,
0.029660247266292572,
0.012752244248986244,
0.04179506376385689,
0.005746821407228708,
0.03331731632351875,
0.0014723261119797826,
0.02428150735795498,
-0.011582694947719574,
0.004482283256947994,
-0.019722046330571175,
-0.0075872293673455715,
0.00215060543268919,
-0.024792073294520378,
0.06910434365272522,
-0.006512668449431658,
-0.03578702360391617,
0.027143044397234917,
-0.007652534171938896,
0.043789830058813095,
-0.04492969438433647,
0.040631454437971115,
0.04720942676067352,
0.03293736279010773,
-0.020268231630325317,
0.04416978359222412,
0.015756264328956604,
-0.003461153944954276,
-0.023450355976819992,
0.014355179853737354,
-0.012289173901081085,
0.056565821170806885,
-0.028116680681705475,
-0.035193346440792084,
0.004123107064515352,
0.00290012639015913,
0.00333351269364357,
-0.0014322528149932623,
0.0351221039891243,
0.0325574055314064,
0.0016830825479701161,
-0.04549962654709816,
0.020945027470588684,
-0.016931751742959023,
-0.021348729729652405,
0.0029357471503317356,
0.04096391424536705,
0.02453085407614708,
0.03402973338961601,
0.03481338918209076,
-0.04208003357052803,
-0.01266912929713726,
0.023640334606170654,
0.019674552604556084,
0.019650805741548538,
0.0023405831307172775,
0.003790646092966199,
-0.03250991180539131,
0.001656366977840662,
-0.021562453359365463,
-0.01213481742888689,
-0.03825673460960388,
0.003140566637739539,
0.032129958271980286,
0.03597700223326683,
-0.03445718064904213,
-0.02814042754471302,
0.005283751059323549,
-0.03241492435336113,
-0.040987659245729446,
-0.06938930600881577,
0.029375281184911728,
0.04549962654709816,
-0.006874813232570887,
-0.040987659245729446,
0.016349945217370987,
0.016931751742959023,
-0.05267127975821495,
-0.005162046756595373,
0.03398223966360092,
-0.002177321119233966,
0.01953206956386566,
-0.010134115815162659,
0.013476533815264702,
0.030420158058404922,
0.0018329867161810398,
0.013096578419208527,
0.003286018269136548,
-0.022001776844263077,
-0.017846018075942993,
-0.023070400580763817,
-0.02880534902215004,
0.00997382216155529,
-0.004595082253217697,
-0.014794503338634968,
0.009112986735999584,
0.03887416049838066,
0.017014866694808006,
-0.02671559527516365,
0.009374205954372883,
-0.022096766158938408,
0.021586202085018158,
0.031678758561611176,
-0.00796718429774046,
-0.005114552564918995,
-0.026596859097480774,
-0.015008227899670601,
-0.02111125737428665,
0.009635425172746181,
-0.00946325808763504,
0.05433358624577522,
0.018890894949436188,
-0.01313219964504242,
-0.02676309086382389,
-0.00857273768633604,
0.012396036647260189,
0.05965295806527138,
-0.05043904483318329,
-0.004025149624794722,
-0.02890033833682537,
-0.024720830842852592,
0.017228590324521065,
0.015744391828775406,
0.030443904921412468,
0.04189005494117737,
0.018130984157323837,
-0.0015732517931610346,
-0.013191567733883858,
0.019757667556405067,
0.0026181284338235855,
-0.01648055389523506,
0.007409125100821257,
0.007456619758158922,
-0.02609816938638687,
0.031631264835596085,
-0.0033305443357676268,
0.0014597104163840413,
-0.025860697031021118,
0.010187547653913498,
0.03436219319701195,
0.04977412149310112,
0.02443586476147175,
0.013749626465141773,
-0.0021743527613580227,
0.0044377571903169155,
-0.015316941775381565,
0.006951991934329271,
-0.00279177981428802,
-0.021657442674040794,
0.01838032901287079,
-0.0071954005397856236,
-0.007367567624896765,
-0.020291978493332863,
0.017596673220396042,
0.024554600939154625,
0.01643306016921997,
-0.02250046841800213,
-0.0037342465948313475,
-0.0037164362147450447,
-0.02626439929008484,
-0.03908788412809372,
-0.017489809542894363,
-0.028330404311418533,
-0.016516175121068954,
-0.01841595023870468,
-0.03785303235054016,
-0.00494832219555974,
-0.013690258376300335,
0.01629057712852955,
-0.007337883580476046,
0.00008942303247749805,
0.02564697153866291,
-0.0006419164128601551,
-0.03343605250120163,
0.0371643602848053,
0.003888603299856186,
-0.03120381571352482,
-0.044193532317876816,
0.05186387524008751,
0.01903337799012661,
-0.04604581370949745,
0.004660387057811022,
-0.0017558083636686206,
-0.010466576553881168,
0.0028719266410917044,
0.030063951388001442,
-0.012704749591648579,
0.014307686127722263,
0.010543755255639553,
0.023450355976819992,
-0.034077227115631104,
0.024257760494947433,
0.0007710417849011719,
0.0019888277165591717,
-0.031227562576532364,
0.0009788296883925796,
0.007331946864724159,
-0.001680114190094173,
0.010828721337020397,
-0.03747307509183884,
0.04286368936300278,
-0.016207462176680565,
0.023723449558019638,
0.008287771604955196,
0.0035442691296339035,
0.02809293381869793,
0.007943437434732914,
-0.008578674867749214,
0.02823541685938835,
-0.022417353466153145,
-0.022809181362390518,
0.02823541685938835,
0.02132498286664486,
0.008074047043919563,
0.03058638796210289,
-0.000943208928219974,
-0.0026285178028047085,
-0.014390801079571247,
-0.015411930158734322,
-0.01053781807422638,
0.046686988323926926,
-0.017133602872490883,
-0.03619072586297989,
0.06112528219819069,
-0.0006419164128601551,
-0.024245887994766235,
-0.010448765940964222,
0.006251449231058359,
0.006298943888396025,
0.012835359200835228,
0.00910704955458641,
0.04794558882713318,
0.03923036903142929,
-0.00018728745635598898,
-0.011018699035048485,
0.033079843968153,
-0.006803571712225676,
-0.021135004237294197,
-0.00548560218885541,
0.001775102922692895,
0.022559836506843567,
-0.001362495357170701,
-0.03165501356124878,
-0.008489622734487057,
-0.0031791559886187315,
0.007177589926868677,
0.043386127799749374,
0.03471840173006058,
0.002269341377541423,
0.0569932721555233,
0.014153328724205494,
-0.013049084693193436,
-0.012550393119454384,
-0.028069185093045235,
-0.003942034672945738,
-0.0152694471180439,
-0.017074234783649445,
-0.03291361406445503,
-0.003478964325040579,
-0.02193053625524044,
-0.020291978493332863,
-0.004333863500505686,
0.026288146153092384,
-0.01923522911965847,
-0.041438858956098557,
-0.014948859810829163,
-0.00633456464856863,
-0.0025172028690576553,
-0.013381545431911945,
0.015150710940361023,
-0.028686612844467163,
-0.02716679312288761,
0.020529450848698616,
-0.00279326387681067,
0.013678384944796562,
0.03806675598025322,
-0.005743853282183409,
0.020018886774778366,
0.01949644833803177,
0.011523326858878136,
-0.007426935713738203,
0.0025008765514940023,
-0.06587472558021545,
0.012716623954474926,
-0.03673691302537918,
-0.0020303851924836636,
0.0026626542676240206,
-0.024305256083607674,
-0.028520382940769196,
-0.0025706340093165636,
0.0028214638587087393,
0.020470082759857178,
-0.006910433992743492,
-0.005423265974968672,
0.011547073721885681,
-0.01720484346151352,
0.013286556117236614,
0.013725879602134228,
-0.05694577842950821,
0.024412117898464203,
-0.01063874363899231,
0.017620420083403587,
0.014212696813046932,
0.0015020101564005017,
-0.03405347838997841,
0.014687640592455864,
0.010597186163067818,
0.011327412910759449,
-0.01618371345102787,
-0.0057230740785598755,
-0.0016177777433767915,
0.0005940509727224708,
0.04763687402009964,
0.012645382434129715,
0.01999513991177082,
-0.02406778372824192,
0.00007402446499327198,
-0.009724477306008339,
0.005209540948271751,
0.015388183295726776,
0.02219175547361374,
0.025362005457282066,
-0.03623822331428528,
-0.0315362773835659,
-0.006904497276991606,
0.01592249423265457,
-0.02127748727798462,
-0.007331946864724159,
0.014283938333392143,
0.0096710454672575,
-0.03996653109788895,
-0.028259163722395897,
-0.01719297096133232,
0.04250748082995415,
-0.002978788921609521,
-0.005521222949028015,
-0.007984994910657406,
-0.040892671793699265,
-0.023996541276574135,
-0.009475131519138813,
0.013690258376300335,
0.011493642814457417,
0.028164174407720566,
-0.0038796982262283564,
0.012491025030612946,
-0.013690258376300335,
0.06425991654396057,
0.023794690147042274,
0.019413333386182785,
-0.012740370817482471,
-0.03293736279010773,
-0.001436705351807177,
0.015459424816071987,
-0.002169900108128786,
-0.004019212909042835,
0.024198392406105995,
-0.0026047704741358757,
-0.021918661892414093,
0.046188294887542725,
-0.013084704987704754,
0.005850715562701225,
-0.0325811542570591,
-0.010294409468770027,
-0.002644843887537718,
-0.002889737021178007,
0.018249720335006714,
0.00506408978253603,
0.0005168725620023906,
-0.009890707209706306,
-0.022262996062636375,
-0.010145989246666431,
-0.02219175547361374,
0.007207273971289396,
-0.009760097600519657,
0.002572118304669857,
0.0027205380611121655,
-0.04193754866719246,
-0.058703068643808365,
0.003146503586322069,
0.0004025891830679029,
-0.016302449628710747,
-0.0075872293673455715,
-0.010009443387389183,
0.009712602943181992,
0.03193997964262962,
-0.030301421880722046,
-0.011327412910759449,
0.026525618508458138,
0.028734106570482254,
0.009807592257857323,
0.020244484767317772,
0.019650805741548538,
0.0015524729387834668,
-0.023747196421027184,
0.006554226391017437,
-0.00495129032060504,
-0.01694362424314022,
0.023236632347106934,
-0.019472701475024223,
-0.0038322038017213345,
0.030301421880722046,
-0.03592950850725174,
0.022168008610606194,
0.0032533658668398857,
-0.025053292512893677,
0.05400112271308899,
-0.010525944642722607,
0.007557545322924852,
-0.010816847905516624,
-0.005414360668510199,
-0.03099009022116661,
0.04492969438433647,
0.01963893137872219,
-0.0027561590541154146,
-0.016195587813854218,
0.02920905128121376,
0.04108265042304993,
-0.01163018960505724,
-0.028876591473817825,
-0.0006604688824154437,
0.025836950168013573,
0.025836950168013573,
0.009273280389606953,
0.004363547079265118,
-0.022357985377311707,
-0.04692446067929268,
0.007385378237813711,
-0.011570821516215801,
-0.018890894949436188,
0.01007474772632122,
0.0028110742568969727,
0.01914023980498314,
0.010163799859583378,
0.014129581861197948,
0.011363033205270767,
-0.004743502475321293,
-0.028924085199832916,
-0.012491025030612946,
-0.014652020297944546,
0.0074625564739108086,
-0.012384163215756416,
-0.00267749628983438,
-0.03291361406445503,
0.015031975694000721,
-0.04203253611922264,
-0.001041166135109961,
-0.000828183488920331,
0.00021428134641610086,
-0.013072831556200981,
-0.002849663607776165,
-0.0006252191378735006,
0.012407910078763962,
-0.022049272432923317,
0.010549691505730152,
-0.013191567733883858,
0.0013706585159525275,
-0.038137998431921005,
-0.011333349160850048,
-0.006738266907632351,
0.0029758205637335777,
-0.05219633877277374,
0.0036184790078550577,
0.005645895842462778,
-0.00920797511935234,
0.01562565565109253,
0.052386313676834106,
-0.01073373295366764,
-0.00622176518663764,
-0.02977898344397545,
0.01046064030379057,
-0.0058596208691596985,
0.045784592628479004,
0.011837976984679699,
-0.021752431988716125,
-0.009225785732269287,
-0.00753379799425602,
-0.0033869438339024782,
-0.008210592903196812,
-0.029280293732881546,
-0.0009150091791525483,
-0.022619204595685005,
-0.0015717674978077412,
-0.0051798573695123196,
-0.012479151599109173,
-0.013155946508049965,
0.023296000435948372,
-0.05271877720952034,
0.004247779957950115,
-0.004292305558919907,
0.025836950168013573,
0.016908003017306328,
0.03837547078728676,
-0.0024489297065883875,
0.016563668847084045,
-0.0002747624821495265,
0.021764304488897324,
-0.0325574055314064,
-0.002879347652196884,
0.0004422915226314217,
-0.022927917540073395,
-0.012550393119454384,
0.026905573904514313,
0.005960546433925629,
-0.01994764432311058,
0.012728497385978699,
-0.0036540997680276632,
-0.0018522812752053142,
0.00569932721555233,
-0.03374476730823517,
0.013440913520753384,
0.0007424709037877619,
0.017632292583584785,
0.012431656941771507,
0.031156321987509727,
-0.043124906718730927,
0.017727281898260117,
-0.03980030119419098,
-0.019104618579149246,
-0.009481067769229412,
-0.03429095074534416,
-0.0029238734859973192,
0.03272363543510437,
0.0010248399339616299,
0.0046544503420591354,
0.016872383654117584,
-0.005405455362051725,
-0.01715734973549843,
0.040892671793699265,
-0.013975225389003754,
-0.01593436859548092,
0.036000750958919525,
-0.017264211550354958,
0.019722046330571175,
0.02600318007171154,
0.01765604130923748,
0.004120138473808765,
0.031583771109580994,
0.004102328326553106,
0.0044377571903169155,
-0.0005844036350026727,
-0.027214286848902702,
0.02320101112127304,
-0.030966343358159065,
0.021087510511279106,
0.11332161724567413,
-0.007058854214847088,
-0.01602935791015625,
0.030420158058404922,
-0.004710849840193987,
-0.017276085913181305,
0.03602449595928192,
-0.022096766158938408,
0.025267016142606735,
-0.006405806168913841,
0.015020101331174374,
0.014841997995972633,
0.01226542703807354,
0.01536443643271923,
-0.003600668627768755,
-0.008750841952860355,
0.005260004196316004,
0.04075019061565399,
-0.025623224675655365,
-0.002092721639201045,
0.013619016855955124,
0.007759396452456713,
-0.009587930515408516,
0.025172028690576553,
-0.014367053285241127,
-0.0032533658668398857,
-0.0031049458775669336,
0.0012689908035099506,
0.021182499825954437,
-0.017074234783649445,
0.011713304556906223,
0.001000350690446794,
-0.007498177234083414,
-0.023485977202653885,
-0.027095550671219826,
-0.040987659245729446,
-0.0050967419520020485,
-0.028377899900078773,
0.00989664439111948,
0.015103217214345932,
-0.022215502336621284,
0.007676281034946442,
-0.014331432990729809,
0.010852469131350517,
0.04742315039038658,
0.009587930515408516,
-0.013049084693193436,
-0.01033003069460392,
0.003740183310583234,
-0.02030385285615921,
0.0195914376527071,
-0.009682918898761272,
0.01629057712852955,
0.014058340340852737,
-0.04075019061565399,
-0.019425205886363983,
0.007961247116327286,
0.01573251746594906,
-0.0208619125187397,
-0.019567688927054405,
-0.023628460243344307,
0.008721157908439636,
0.003511616727337241,
0.0020199958235025406,
0.009178291074931622
] | 2025-01-20 | 1 | 39831708 | [
"cancer treatment",
"remission rates",
"Chimeric antigen receptor",
"CAR",
"interest",
"previously incurable hematological cancers",
"CD4",
"CAR) T-cell therapy",
"the CAR platform",
"a small yet pivotal subset",
"the face",
"These successes"
] | [] | 0 | 10.3791/67200 | [
"Cochrane",
"Robino",
"Ferreira"
] | [
"Department of Microbiology and Immunology, Medical University of South Carolina; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina; Hollings Cancer Center, Medical University of South Carolina.",
"Department of Microbiology and Immunology, Medical University of South Carolina; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina; Hollings Cancer Center, Medical University of South Carolina.",
"Department of Microbiology and Immunology, Medical University of South Carolina; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina; Hollings Cancer Center, Medical University of South Carolina; [email protected]."
] | [
"39831708"
] | [] | 8.089559 | 4.375112 |
39825416 | 15 | Multinational retrospective analysis of bridging therapy prior to chimeric antigen receptor t cells for relapsed/refractory acute lymphoblastic leukemia in children and young adults. | Anti-CD19 chimeric antigen receptor T cells (CAR) are a well-established treatment option for children and young adults suffering from relapsed/refractory B-lineage acute lymphoblastic leukemia. Bridging therapy is used to control disease prior to start of lymphodepletion before CAR infusion and thereby improve efficacy of CAR therapy. However, the effect of different bridging strategies on outcome, side effects and response to CAR therapy is still poorly understood. In this retrospective, multinational study, real-world data were collected from 14 different sites in Germany, Austria and Switzerland on 88 patients receiving 93 2nd-generation CAR therapies. Bridging therapy was classified into the categories 1) no systemic therapy (15/93 treatments), 2) low-intensity therapy (38/93 treatments) and 3) high-intensity therapy (39/93 treatments). We analyzed the impact of bridging regimens on clinical outcome. Patients receiving a high-intensity bridging therapy had a significantly higher tumor burden at time of eligibility compared to patients treated with a low-intensity or no systemic bridging therapy. They suffered significantly more from bacterial adverse events and mucositis. Overall survival was significantly better for patients who did not receive any bridging therapy in comparison to patients who had been treated with a low- or high-intensity bridging regimen. In conclusion, in this retrospective cohort, high-intensity bridging therapy has not improved the outcome in terms of overall and progression-free survival in comparison to a low-intensity therapy. Yet, high-intensity bridging therapy was associated with more adverse events. Our study suggests that a low-intensity bridging regimen may be preferred whenever tumor burden and disease kinetics allow this treatment strategy. | [
0.007020209450274706,
0.020689120516180992,
0.06338685005903244,
0.06635890901088715,
-0.005636664107441902,
0.013169297948479652,
0.0032891216687858105,
-0.0017230258090421557,
0.014514410868287086,
0.017191825434565544,
-0.03438365086913109,
-0.028413912281394005,
-0.041275754570961,
0.03715074062347412,
0.017191825434565544,
-0.02591584622859955,
0.07466018199920654,
-0.015116509050130844,
0.009595139883458614,
0.03861115127801895,
0.04355604201555252,
-0.0008222804171964526,
-0.02913130633533001,
-0.007097072899341583,
-0.015628932043910027,
-0.012791384942829609,
0.020855657756328583,
0.00006680528167635202,
-0.002491661813110113,
-0.020932521671056747,
0.0201638862490654,
-0.013937933370471,
-0.022047044709324837,
-0.0008871341124176979,
-0.012150854803621769,
0.03381998464465141,
0.020586635917425156,
0.012503146193921566,
0.009018663316965103,
-0.02451949007809162,
0.047809161245822906,
0.004470899701118469,
0.023007838055491447,
0.06502661108970642,
-0.06436045467853546,
-0.010005079209804535,
0.019267143681645393,
-0.06364306807518005,
0.01694842427968979,
-0.015206183306872845,
-0.027004746720194817,
0.0013939534546807408,
-0.01480905432254076,
0.03148845583200455,
-0.0410451665520668,
0.04271054267883301,
0.004144229460507631,
-0.013086028397083282,
0.0056014349684119225,
-0.006261181086301804,
0.040250908583402634,
-0.011696078814566135,
0.02050977200269699,
-0.02913130633533001,
-0.06436045467853546,
-0.015321478247642517,
-0.039610378444194794,
0.0060273874551057816,
-0.007961788214743137,
0.02785024605691433,
0.0027414686046540737,
0.02498067170381546,
0.024596353992819786,
0.00013371065142564476,
0.014347872696816921,
0.02577492967247963,
0.005534179508686066,
0.03159094229340553,
0.01698685623705387,
-0.01047907117754221,
0.021393703296780586,
-0.007161126006394625,
-0.02851639688014984,
-0.04517017677426338,
0.011061953380703926,
-0.011023522354662418,
0.012682494707405567,
-0.01790921948850155,
-0.008454996161162853,
-0.016295084729790688,
-0.01496278215199709,
-0.00018024916062131524,
-0.051139917224645615,
0.038995467126369476,
0.0193952489644289,
0.020535392686724663,
-0.01603887230157852,
-0.015385531820356846,
0.0189212579280138,
0.008634344674646854,
0.046861179172992706,
0.018626613542437553,
0.005793594289571047,
-0.04432467743754387,
0.06343809515237808,
-0.025377800688147545,
-0.02049696072936058,
0.0190365519374609,
0.03405057638883591,
-0.03966161981225014,
0.03133472800254822,
0.01425819844007492,
-0.0011849806178361177,
0.04547763243317604,
-0.0027831029146909714,
-0.0425824373960495,
-0.0483984500169754,
-0.024212036281824112,
-0.027414685115218163,
0.05283091589808464,
-0.021842073649168015,
0.023469021543860435,
0.033538151532411575,
0.004797569941729307,
0.027132852002978325,
-0.01368172187358141,
0.083268903195858,
-0.03799624368548393,
-0.0374838188290596,
-0.09285123646259308,
0.029669351875782013,
0.0009103533229790628,
0.017678629606962204,
-0.026774154976010323,
-0.06886979192495346,
0.008173163048923016,
-0.007494201418012381,
-0.007116288878023624,
-0.028567640110850334,
-0.013246160931885242,
0.007596686482429504,
-0.04460651054978371,
-0.011074764654040337,
0.014847486279904842,
-0.022136718034744263,
0.01208039652556181,
-0.004967310465872288,
0.038995467126369476,
0.030694199725985527,
0.032897621393203735,
-0.037048257887363434,
0.05093494802713394,
0.04996134340763092,
0.011638430878520012,
-0.0026389837730675936,
-0.05892876535654068,
-0.030668579041957855,
0.03717636317014694,
0.0009992268169298768,
-0.022969407960772514,
-0.01730712130665779,
0.0260951928794384,
-0.029694972559809685,
-0.0358184389770031,
0.0014756211312487721,
-0.04132699966430664,
-0.02272600494325161,
0.036279622465372086,
-0.06379678845405579,
0.012925895862281322,
-0.02257227897644043,
-0.03791937977075577,
-0.057391490787267685,
-0.011401434428989887,
-0.0288238525390625,
-0.018139811232686043,
0.002123357029631734,
-0.021073438227176666,
0.027824625372886658,
0.025992708280682564,
0.010434234514832497,
0.033871229737997055,
0.022854112088680267,
0.011670457199215889,
-0.06866481900215149,
0.017870787531137466,
-0.06241324543952942,
0.02767089754343033,
-0.060927215963602066,
0.023814907297492027,
0.01988205313682556,
0.003058530855923891,
0.06456542760133743,
0.012618442066013813,
-0.009230038151144981,
-0.020112643018364906,
0.02367399074137211,
0.027645276859402657,
-0.04040463641285896,
-0.025236884132027626,
0.026646049693226814,
-0.060466036200523376,
-0.002727056620642543,
-0.02897757850587368,
-0.002108945045620203,
-0.00006645498797297478,
-0.02143213525414467,
0.03458862379193306,
-0.008691992610692978,
-0.018793150782585144,
0.0153599102050066,
-0.008877746760845184,
-0.041993148624897,
0.021227166056632996,
-0.03794499859213829,
-0.030976032838225365,
-0.0025557149201631546,
0.04865466058254242,
0.03630524128675461,
-0.0025557149201631546,
0.025992708280682564,
0.000643732666503638,
-0.008064272813498974,
0.020368855446577072,
-0.03205212205648422,
0.00036730393185280263,
-0.01473219133913517,
-0.023609938099980354,
-0.018447265028953552,
-0.0534970685839653,
0.010030700825154781,
0.025659633800387383,
0.010075537487864494,
-0.03458862379193306,
-0.020240748301148415,
-0.009262064471840858,
-0.021649915724992752,
-0.018447265028953552,
0.07173936069011688,
-0.04309486225247383,
-0.010748093947768211,
0.007161126006394625,
0.03743257373571396,
-0.027158474549651146,
-0.05698155239224434,
-0.012669684365391731,
-0.02703036740422249,
-0.06113218516111374,
0.021406514570116997,
0.000618111458607018,
-0.049064602702856064,
0.006565432995557785,
-0.024455437436699867,
-0.0387904979288578,
0.007596686482429504,
-0.007366095669567585,
0.045067694038152695,
-0.03405057638883591,
0.018139811232686043,
-0.023328103125095367,
0.009774488396942616,
0.009646382182836533,
0.0054028709419071674,
-0.03389684855937958,
-0.05431694909930229,
0.018114188686013222,
0.013028381392359734,
0.037227604538202286,
0.002480452647432685,
-0.027696518227458,
0.016423190012574196,
-0.000652539951261133,
0.05400949344038963,
-0.027773382142186165,
-0.043171726167201996,
-0.003881612094119191,
0.059646155685186386,
-0.0026021532248705626,
0.0004251518112141639,
0.02129121869802475,
0.012868248857557774,
0.008608723990619183,
-0.016243841499090195,
-0.02290535345673561,
0.017204636707901955,
0.010037105530500412,
0.007231584284454584,
0.008525454439222813,
0.023251241073012352,
0.0016573715256527066,
-0.02272600494325161,
0.0010969076538458467,
0.007257205434143543,
-0.04342793673276901,
-0.002720651449635625,
-0.012150854803621769,
0.01954897679388523,
-0.042479950934648514,
-0.0021441744174808264,
0.03638210520148277,
-0.02191893756389618,
0.05234411358833313,
-0.001702208537608385,
0.019600220024585724,
0.04460651054978371,
0.0169612355530262,
-0.02895195782184601,
-0.0029768634121865034,
-0.0005780783831141889,
0.05057625100016594,
0.016717834398150444,
0.013111650012433529,
-0.0025973492302000523,
0.021995801478624344,
0.00873042456805706,
0.03517790883779526,
0.03745819628238678,
-0.07414776086807251,
0.021867696195840836,
-0.04340231418609619,
-0.015078077092766762,
-0.007891329936683178,
-0.030386745929718018,
0.00007391116378130391,
0.012266150675714016,
-0.022034233435988426,
0.005793594289571047,
-0.007532633375376463,
0.023802096024155617,
-0.026312973350286484,
-0.0012081997701898217,
-0.021893316879868507,
0.061080943793058395,
-0.017166204750537872,
0.014296630397439003,
0.016884371638298035,
-0.005931308027356863,
-0.041224513202905655,
0.03153970092535019,
0.0007161926478147507,
0.03138597309589386,
0.03212898597121239,
-0.036279622465372086,
0.0534970685839653,
0.004637437406927347,
-0.02738906443119049,
0.000743815500754863,
0.022661952301859856,
0.006190722808241844,
-0.0047143008559942245,
0.0028567640110850334,
-0.03397371247410774,
0.009684814140200615,
0.005399668123573065,
0.007391716819256544,
0.03984097018837929,
0.013009165413677692,
-0.023789284750819206,
-0.026799777522683144,
0.025390610098838806,
0.025006292387843132,
0.01056234072893858,
-0.05119116231799126,
0.04455526918172836,
-0.020061401650309563,
0.05457315966486931,
-0.005367641802877188,
0.014373494312167168,
-0.027645276859402657,
-0.061388399451971054,
0.003859193529933691,
-0.00046998891048133373,
0.024391384795308113,
0.02318718656897545,
-0.025813359767198563,
0.05298464372754097,
0.03556222841143608,
0.015078077092766762,
0.03397371247410774,
0.0053163995034992695,
0.030335502699017525,
-0.009223632514476776,
-0.004262727219611406,
-0.038175590336322784,
-0.002368359826505184,
0.046195026487112045,
0.006517393048852682,
0.006293207406997681,
-0.07870832830667496,
0.019817998632788658,
-0.004608613438904285,
0.022956596687436104,
0.04207001253962517,
-0.012996354140341282,
0.005540584679692984,
0.06615394353866577,
-0.014706569723784924,
0.06574400514364243,
0.044401541352272034,
0.0016325509641319513,
-0.018972499296069145,
-0.04655372351408005,
-0.03379436582326889,
-0.04037901386618614,
0.03922605887055397,
-0.025493094697594643,
0.002872777171432972,
-0.002502871211618185,
0.04224936291575432,
-0.024224845692515373,
-0.016538485884666443,
0.011593593284487724,
0.0320265032351017,
-0.0004932081210426986,
0.023635558784008026,
-0.013758584856987,
-0.03041236661374569,
0.05416322126984596,
-0.05334334075450897,
0.03133472800254822,
0.06359182298183441,
-0.013912312686443329,
0.01329740323126316,
-0.03346128761768341,
0.028132079169154167,
-0.017499281093478203,
0.055649250745773315,
0.0046022082678973675,
-0.012874653562903404,
-0.04022528603672981,
-0.02143213525414467,
0.06338685005903244,
0.012426283210515976,
-0.0075006065890192986,
0.011100385338068008,
0.06574400514364243,
-0.02690226212143898,
0.033691879361867905,
-0.01651286520063877,
0.0169612355530262,
-0.01297073345631361,
0.04593881592154503,
-0.010837768204510212,
-0.030694199725985527,
-0.014283820055425167,
-0.03123224526643753,
0.018677856773138046,
0.06200330704450607,
-0.030361123383045197,
-0.011926669627428055,
-0.0425824373960495,
-0.025979898869991302,
0.009966647252440453,
-0.002488459227606654,
-0.021175922825932503,
0.015500826761126518,
-0.007981004193425179,
-0.020394476130604744,
-0.018485696986317635,
0.030309882014989853,
0.03543412312865257,
-0.021521808579564095,
-0.013374267145991325,
-0.021035006269812584,
-0.016384758055210114,
0.07322539389133453,
-0.0014355879975482821,
-0.012554388493299484,
-0.002872777171432972,
-0.015744227916002274,
0.018805962055921555,
-0.019331196323037148,
-0.03694577142596245,
-0.018139811232686043,
0.02466040663421154,
0.07240551710128784,
0.006860076915472746,
0.0208172257989645,
0.030642956495285034,
0.006731970701366663,
-0.013425509445369244,
-0.02674853429198265,
-0.0008999446872621775,
-0.02207266539335251,
0.0476810559630394,
0.029643729329109192,
0.00801943615078926,
0.010517503134906292,
-0.04560573771595955,
0.02127840742468834,
0.0016293482622131705,
-0.012989949434995651,
0.03553660586476326,
-0.01336145680397749,
-0.01240066159516573,
-0.029490003362298012,
0.011728105135262012,
0.0015909165376797318,
0.0016285476740449667,
-0.0017374376766383648,
0.009089121595025063,
0.02354588359594345,
0.015078077092766762,
0.02352026291191578,
0.0326157882809639,
0.011907453648746014,
-0.0013186911819502711,
0.041634451597929,
-0.033717501908540726,
-0.024545110762119293,
-0.030181774869561195,
-0.03538287803530693,
0.027594033628702164,
0.009338928386569023,
-0.0629769116640091,
0.0001287065097130835,
-0.028542019426822662,
-0.005031363572925329,
0.012618442066013813,
0.002371562412008643,
-0.03489607572555542,
-0.02049696072936058,
0.002094533294439316,
0.0094606289640069,
0.015564880333840847,
0.0061490884982049465,
-0.022380119189620018,
-0.05365079641342163,
-0.02097095362842083,
-0.02690226212143898,
0.022047044709324837,
-0.0048360018990933895,
0.010235670022666454,
0.03950789198279381,
-0.04627189040184021,
-0.007916951552033424,
-0.03471672907471657,
0.012874653562903404,
-0.008166758343577385,
-0.01345113106071949,
-0.026184868067502975,
0.005255548749119043,
-0.007993814535439014,
0.03358939662575722,
0.01386107038706541,
-0.004819988738745451,
0.04693804308772087,
-0.04391473904252052,
0.0008262837654910982,
-0.017371173948049545,
0.03284638002514839,
-0.018844394013285637,
0.026697292923927307,
0.02482694387435913,
0.019344007596373558,
-0.01600044034421444,
-0.013489563018083572,
-0.03205212205648422,
-0.013963554985821247,
-0.012304581701755524,
-0.007487796247005463,
-0.011036332696676254,
0.01793484017252922,
-0.028132079169154167,
-0.04017404466867447,
0.009159579873085022,
0.026184868067502975,
-0.047783542424440384,
-0.024916619062423706,
0.013886691071093082,
-0.045042071491479874,
0.006520595867186785,
0.02946438267827034,
-0.018805962055921555,
0.02546747401356697,
-0.016705023124814034,
-0.011420650407671928,
0.04437592253088951,
0.014604085125029087,
0.01343831978738308,
-0.02386614866554737,
-0.018498508259654045,
-0.013284592889249325,
0.038662392646074295,
-0.01566736400127411,
0.008852125145494938,
-0.036766424775123596,
-0.02319999784231186,
0.00497051328420639,
0.029566867277026176,
-0.0013803421752527356,
0.001587713835760951,
0.07168812304735184,
-0.003210656810551882,
-0.0009736056672409177,
0.003036112291738391,
0.02254665642976761,
-0.012246934697031975,
-0.031104138121008873,
-0.005678298883140087,
0.046348754316568375,
-0.03599778935313225,
-0.022162338718771935,
-0.04499083012342453,
-0.011881832033395767,
0.03317945450544357,
-0.009499060921370983,
-0.02785024605691433,
0.01871628686785698,
0.01967708207666874,
0.05780142918229103,
0.04132699966430664,
0.002203423297032714,
0.0030681388452649117,
0.033871229737997055,
0.032743897289037704,
-0.020407287403941154,
-0.022661952301859856,
0.03397371247410774,
-0.03989221155643463,
-0.013656100258231163,
0.01217007078230381,
-0.021163111552596092,
0.01648724265396595,
0.02831142768263817,
-0.022047044709324837,
-0.006177912000566721,
0.007391716819256544,
0.024878187105059624,
0.011478298343718052,
-0.005518166348338127,
-0.03517790883779526,
-0.00044276638072915375,
0.013604857958853245,
-0.03615151718258858,
-0.027440307661890984,
0.022533847019076347,
0.01343831978738308,
-0.027337821200489998,
0.016602538526058197,
-0.013143676333129406,
0.011068359017372131,
0.019267143681645393,
-0.030207397416234016,
0.01842164434492588,
0.004973715636879206,
-0.030233018100261688,
0.013233350589871407,
-0.03325631842017174,
-0.008282053284347057,
-0.01760176569223404,
-0.0451957993209362,
0.007334068883210421,
-0.007391716819256544,
0.0224185511469841,
-0.03584406152367592,
-0.010094753466546535,
0.008531860075891018,
0.03886736184358597,
0.04914146289229393,
-0.005598232615739107,
0.008077084086835384,
-0.022508226335048676,
-0.0001775469136191532,
0.021765211597085,
0.018844394013285637,
0.04432467743754387,
0.012624846771359444,
0.01056234072893858,
0.00370226358063519,
0.1175500750541687,
0.0365358330309391,
0.029080063104629517,
-0.033051349222660065,
-0.03907233104109764,
-0.012919491156935692,
-0.022008612751960754,
0.01322054024785757,
-0.0361771360039711,
-0.0021361676044762135,
-0.023443398997187614,
0.004342793487012386,
-0.023789284750819206,
-0.03840618208050728,
0.02339215762913227,
0.012688900344073772,
0.022854112088680267,
0.0005824820254929364,
0.02608238346874714,
-0.005172280129045248,
0.0016685808077454567,
-0.008999447338283062,
-0.02127840742468834,
-0.0026565983425825834,
0.03574157506227493,
0.017217447981238365,
-0.011484703980386257,
-0.011126006953418255,
-0.028721366077661514,
-0.039302922785282135,
0.0346398651599884,
-0.005844836588948965,
0.04260805994272232,
0.0006000965950079262,
0.02131683938205242,
-0.020945332944393158,
0.009659192524850368,
-0.024071119725704193,
0.007065046112984419,
0.01177934743463993,
0.024404194205999374,
0.012195692397654057,
-0.018472885712981224,
-0.04037901386618614,
0.0068792924284935,
0.02560839056968689,
-0.0035773601848632097,
0.04404284432530403,
0.02286692149937153,
0.007007398642599583,
-0.0027510765939950943,
0.036228377372026443,
-0.01729431189596653,
-0.013098839670419693,
0.006219546776264906,
0.04801413044333458,
-0.029515624046325684,
0.06456542760133743,
-0.0173199325799942,
0.010863389819860458,
0.0037310875486582518,
-0.005934510845690966,
-0.016371948644518852,
-0.014014797285199165,
-0.02690226212143898,
0.037535060197114944,
-0.0026277743745595217,
-0.012772168964147568,
-0.008141136728227139,
0.010120374150574207,
0.02772214077413082,
-0.028746988624334335,
-0.03535725921392441,
0.012426283210515976,
0.019574597477912903,
-0.005771175492554903,
0.055393036454916,
0.03635648638010025,
0.00038351735565811396,
-0.03341004624962807,
0.013989175669848919,
0.010914632119238377,
0.0033627827651798725,
0.006184317637234926,
0.0011993924854323268,
-0.04304361715912819,
0.02946438267827034,
-0.00014662132889498025,
-0.009793704375624657,
-0.03310259059071541,
0.00014712174015585333,
0.013592047616839409,
-0.0018335172208026052,
0.003676642430946231,
0.003349972190335393,
0.017473658546805382,
0.0015284648397937417,
0.0020304801873862743,
-0.012041964568197727,
-0.016064492985606194,
-0.03602340817451477,
-0.00019215901556890458,
0.022687574848532677,
-0.0034428490325808525,
0.005585421808063984,
0.00719955749809742,
-0.0108826057985425,
-0.0010504692327231169,
-0.020586635917425156,
0.002385974396020174,
0.00648856908082962,
0.014514410868287086,
-0.03041236661374569,
0.035152290016412735,
-0.035126667469739914,
0.0036061841528862715,
0.0009976255241781473,
0.02738906443119049,
-0.015744227916002274,
-0.0019360020523890853,
-0.009672003798186779,
0.014360683038830757,
-0.023315293714404106,
-0.0064277187921106815,
0.008185974322259426,
0.036587074398994446,
0.032410819083452225,
-0.07814466208219528,
0.007398121990263462,
-0.013976365327835083,
0.01336145680397749,
-0.03589530289173126,
0.027568412944674492,
0.0018783543491736054,
0.0018607397796586156,
0.011625620536506176,
0.00364461587741971,
0.033230699598789215,
-0.030796684324741364,
-0.0003927249927073717,
-0.0013915514573454857,
-0.03848304599523544,
0.00500574242323637,
-0.004272335208952427,
-0.02400706522166729,
-0.016397569328546524,
0.006853671278804541,
0.013707342557609081,
0.031129760667681694,
0.014475978910923004,
0.04145510494709015,
-0.026697292923927307,
0.0053548309952020645,
0.006485366728156805,
0.021496187895536423,
-0.010895416140556335,
0.0033916065003722906,
0.0308991689234972,
0.01857537031173706,
-0.020099831745028496,
-0.0006441330187954009,
-0.003090557409450412,
-0.0049224733375012875,
-0.0017182218143716455,
0.0013971561565995216,
0.011093980632722378,
0.013054002076387405,
-0.0045157368294894695,
0.014283820055425167,
0.0365358330309391,
0.013950744643807411,
0.00011899846867891029,
0.008474212139844894,
-0.0429411344230175,
-0.013656100258231163,
0.037073880434036255,
0.004374820273369551,
-0.003785532433539629,
-0.007955383509397507,
-0.01272092666476965,
0.003330756211653352,
-0.012823411263525486,
-0.018805962055921555,
-0.004957702476531267,
0.004339591134339571,
0.011055548675358295,
-0.005569408647716045,
-0.012913085520267487,
0.040430255234241486,
0.028465155512094498,
-0.008346106857061386,
0.021099058911204338,
-0.011158033274114132,
-0.047296736389398575,
0.04534952715039253,
-0.01758895441889763,
0.015475206077098846,
0.008038652129471302,
-0.01683313027024269,
-0.04276178404688835,
0.038662392646074295,
-0.0051946984604001045,
0.04473461955785751,
0.010235670022666454,
-0.009101931937038898,
0.012842627242207527,
0.017742682248353958,
-0.0005752760334871709,
-0.01665378175675869,
-0.026146436110138893,
-0.0013138871872797608,
-0.011984316632151604,
-0.033230699598789215,
0.0013483157381415367,
0.022367309778928757,
0.0011833792086690664,
0.0260951928794384,
-0.009870568290352821,
-0.0017006072448566556,
0.019779566675424576,
0.004297956358641386,
-0.006325234193354845,
-0.005066592711955309,
-0.01496278215199709,
0.010434234514832497,
0.002815129468217492,
-0.019779566675424576,
0.049218326807022095,
-0.0393797867000103,
0.03156531974673271,
-0.012842627242207527,
-0.0051562669686973095,
0.0010913030710071325,
-0.0051946984604001045,
-0.008711208589375019,
-0.016871560364961624,
-0.02738906443119049,
0.05170358344912529,
0.023340914398431778,
0.025403421372175217,
-0.0101716173812747,
0.0016685808077454567,
-0.005572611466050148,
0.014335062354803085,
-0.002829541452229023,
0.025198452174663544,
-0.012849032878875732,
0.05198541656136513,
-0.0035901707597076893,
-0.01584671251475811,
-0.0169612355530262,
-0.024365762248635292,
-0.002480452647432685,
0.03566471114754677,
-0.025377800688147545,
-0.0031770290806889534,
0.00703942496329546,
-0.0041218106634914875,
0.0288238525390625,
0.0028375480324029922,
0.006751186680048704,
0.01297073345631361,
0.018959689885377884,
0.015257425606250763,
0.027901489287614822,
-0.0009672003798186779,
0.027491549029946327,
-0.0029656540136784315,
-0.009242848493158817,
0.011587188579142094,
-0.015616122633218765,
0.020215127617120743,
-0.014232577756047249,
-0.030617335811257362,
0.011875427328050137,
-0.008365321904420853,
0.028285806998610497,
-0.03364063799381256,
0.024698838591575623,
0.014155713841319084,
0.03858552873134613,
-0.005870457738637924,
0.030489230528473854,
0.0005340419011190534,
-0.02574930712580681,
0.0026581997517496347,
-0.004381225444376469,
-0.057237762957811356,
0.04496520757675171,
-0.03528039529919624,
-0.017653007060289383,
0.04478586092591286,
-0.005844836588948965,
0.006661512423306704,
-0.017012476921081543,
0.020548203960061073,
-0.0008471009787172079,
0.01697404682636261,
-0.06584648787975311,
0.025031913071870804,
-0.017563333734869957,
-0.0035036993212997913,
0.01145908236503601,
0.015949197113513947,
0.043632905930280685,
0.057545218616724014,
0.023289673030376434,
-0.01679469831287861,
0.004589397925883532,
0.01111960131675005,
0.008736829273402691,
0.027107231318950653,
-0.0019039754988625646,
-0.03328194096684456,
-0.033845607191324234,
0.01984362117946148,
-0.03302573040127754,
-0.008461401797831059,
0.0153599102050066,
0.02129121869802475,
0.026620429009199142,
0.038636770099401474,
-0.04096830263733864,
-0.0054348972626030445,
0.030233018100261688,
-0.06159336864948273,
-0.01999734714627266,
-0.06512909382581711,
0.009249254129827023,
0.058006402105093,
-0.0007290032226592302,
-0.004506128840148449,
-0.0005960932467132807,
0.005787189118564129,
-0.04481147974729538,
-0.004829596262425184,
0.03330756351351738,
-0.0185625609010458,
0.03727884963154793,
-0.0448371022939682,
0.028900714591145515,
-0.00013581238454207778,
0.008506238460540771,
-0.002214632695540786,
-0.02690226212143898,
-0.009633571840822697,
-0.016717834398150444,
-0.021073438227176666,
-0.018998121842741966,
0.005777581129223108,
-0.002803920302540064,
0.0050345659255981445,
-0.026799777522683144,
0.05344582721590996,
0.0201638862490654,
-0.004016123246401548,
0.02211109735071659,
-0.010190833359956741,
0.0047559356316924095,
0.002160187577828765,
-0.00999867357313633,
-0.01648724265396595,
-0.006209938786923885,
-0.013399888761341572,
-0.006712754722684622,
-0.036433350294828415,
-0.012682494707405567,
0.04755295068025589,
-0.0063476525247097015,
-0.008378133177757263,
-0.02897757850587368,
-0.018319159746170044,
-0.023635558784008026,
0.01496278215199709,
-0.04629751294851303,
-0.01776830293238163,
0.005591827444732189,
-0.025172829627990723,
0.021368082612752914,
0.031795911490917206,
0.019318385049700737,
0.039943452924489975,
-0.012426283210515976,
-0.01569298654794693,
0.004025731235742569,
0.014130092225968838,
-0.008096300065517426,
-0.007103478070348501,
0.004631032235920429,
-0.008627939969301224,
-0.028080837801098824,
0.03148845583200455,
0.03709949925541878,
-0.010030700825154781,
0.015423963777720928,
-0.00889055710285902,
0.012829816900193691,
0.01200993824750185,
-0.006757591851055622,
0.005409276112914085,
-0.003478078171610832,
-0.021188734099268913,
-0.010049915872514248,
0.025967087596654892,
-0.014130092225968838,
0.03159094229340553,
-0.018972499296069145,
-0.011414245702326298,
-0.021701157093048096,
-0.005812810268253088,
0.01040861289948225,
0.03169342502951622,
0.027824625372886658,
-0.022341687232255936,
-0.04401722550392151,
-0.006222749128937721,
-0.021496187895536423,
-0.029899941757321358,
0.023609938099980354,
-0.013835448771715164,
-0.007327663712203503,
0.021496187895536423,
-0.02818332239985466,
-0.006591054145246744,
-0.016551295295357704,
0.036100272089242935,
0.010677635669708252,
-0.010921036824584007,
0.02995118498802185,
-0.0009007453918457031,
-0.001047266647219658,
0.023738043382763863,
-0.02127840742468834,
-0.010382992215454578,
-0.032103367149829865,
0.004816785920411348,
-0.040891438722610474,
-0.030976032838225365,
0.03774002939462662,
-0.004499723669141531,
-0.04783478379249573,
-0.014424736611545086,
0.011670457199215889,
-0.02548028528690338,
0.023161565884947777,
0.01839602179825306,
0.006101048551499844,
-0.017255879938602448,
0.017371173948049545,
-0.016218220815062523,
-0.013989175669848919,
-0.023097513243556023,
0.0003012492961715907,
-0.008128326386213303,
0.0033659853506833315,
-0.00671915989369154,
-0.020932521671056747,
0.002568525495007634,
0.00011379416537238285,
-0.01320772897452116,
0.012695305049419403,
-0.0037887352518737316,
0.015001213178038597,
0.016525674611330032,
0.019139038398861885,
-0.00985775701701641,
-0.04962826892733574,
0.014860296621918678,
0.03302573040127754,
-0.004057758022099733,
-0.001078492496162653,
0.027875866740942,
-0.027414685115218163,
0.01744803786277771,
-0.021726779639720917,
-0.0071547203697264194,
-0.016448810696601868,
0.06881854683160782,
-0.012407067231833935,
-0.05108867585659027,
0.04501645267009735,
-0.0003699061053339392,
-0.006597459316253662,
-0.0027078406419605017,
-0.0026373823639005423,
-0.011286139488220215,
-0.003561347024515271,
-0.006738375872373581,
0.01858818158507347,
0.041890665888786316,
-0.024096740409731865,
-0.009876972995698452,
0.010133185423910618,
0.011241301894187927,
0.009204416535794735,
0.017832355573773384,
0.017512090504169464,
0.005169077310711145,
0.017358364537358284,
-0.02656918577849865,
0.029515624046325684,
-0.005217117257416248,
0.01304119173437357,
0.03838055953383446,
0.03586968034505844,
0.023584315553307533,
0.03325631842017174,
0.017742682248353958,
-0.0023331306874752045,
-0.012426283210515976,
0.003798343241214752,
-0.028875093907117844,
-0.022200770676136017,
-0.028900714591145515,
-0.027875866740942,
-0.0008503036224283278,
-0.0059152948670089245,
-0.00492567615583539,
-0.0007850496331229806,
0.008051462471485138,
-0.016525674611330032,
-0.0410451665520668,
-0.02576211839914322,
0.017729870975017548,
0.008448591455817223,
0.03556222841143608,
-0.001876753056421876,
-0.035126667469739914,
-0.022162338718771935,
0.03151407837867737,
-0.010184427723288536,
-0.009326117113232613,
0.029413139447569847,
0.007263610605150461,
0.020420096814632416,
0.012797790579497814,
-0.01743522845208645,
-0.020765984430909157,
-0.01017802208662033,
-0.052933402359485626,
-0.005207509268075228,
-0.01031893864274025,
-0.020855657756328583,
0.010773715563118458,
0.011350192129611969,
-0.04399160295724869,
-0.005431694909930229,
0.03366626054048538,
-0.005803202278912067,
-0.006815239787101746,
0.010466260835528374,
-0.008621534332633018,
-0.017524901777505875,
0.014027607627213001,
0.02177802100777626,
-0.011612809263169765,
0.016243841499090195,
0.010587961412966251,
-0.0011153229279443622,
-0.005710325203835964,
-0.006802428979426622,
-0.029720593243837357,
0.00921722687780857,
0.0348704569041729,
0.03300010785460472,
-0.016692213714122772,
0.0023155161179602146,
-0.014309440739452839,
-0.0032234673853963614,
0.06072224676609039,
-0.0003665032854769379,
0.002363555831834674,
-0.006382881663739681,
0.0017806735122576356,
-0.014847486279904842,
-0.007577470503747463,
0.029643729329109192,
0.01790921948850155,
0.03461424261331558,
-0.031181002035737038,
-0.021252786740660667,
-0.022328877821564674,
-0.0053484258241951466,
-0.022456983104348183,
-0.012656874023377895,
0.037227604538202286,
0.019971726462244987,
0.0029400328639894724,
-0.020625067874789238,
-0.024250466376543045,
0.008211595006287098,
0.006053009070456028,
0.0045958030968904495,
-0.003236277960240841,
0.00340441707521677,
-0.000929569243453443,
0.0057487571612000465,
0.01496278215199709,
0.01256079412996769,
0.03602340817451477,
0.013822638429701328,
0.022777248173952103,
-0.052933402359485626,
0.03528039529919624,
0.003430038457736373,
-0.0026934288907796144,
0.02738906443119049,
-0.01320772897452116,
0.028234563767910004,
-0.005233130417764187,
-0.0050826058723032475,
0.025006292387843132,
0.019946105778217316,
-0.011862616054713726,
-0.0037310875486582518,
0.018536940217018127,
0.006299613043665886,
-0.024391384795308113,
-0.015334289520978928,
-0.00680883415043354,
-0.01711496338248253,
0.01662815921008587,
-0.00967840850353241,
-0.014309440739452839,
-0.0068216449581086636,
-0.019446492195129395,
0.015885144472122192,
-0.018152620643377304,
-0.02672291360795498,
-0.01919027976691723,
-0.028900714591145515,
0.01072887796908617,
-0.012669684365391731,
-0.02576211839914322,
-0.013797016814351082,
0.020215127617120743,
0.020227938890457153,
-0.021867696195840836,
-0.02992556430399418,
-0.01860099285840988,
-0.017383985221385956,
0.04063522443175316,
-0.031616561114788055,
0.020612256601452827,
0.02576211839914322,
0.027927109971642494,
0.009947431273758411,
0.00832048524171114,
-0.007013803813606501,
0.01320772897452116,
-0.01159999892115593,
-0.045708224177360535,
0.004493318032473326,
0.002610159805044532,
0.02851639688014984,
-0.02400706522166729,
0.004057758022099733,
-0.0006633489392697811,
-0.0316678062081337,
0.048090994358062744,
0.0153599102050066,
-0.02464759536087513,
0.041378241032361984,
-0.02626173198223114,
-0.012663278728723526,
0.0024388181045651436,
-0.031642183661460876,
-0.008045056834816933,
-0.006904914043843746,
0.036740802228450775,
-0.026825398206710815,
0.0222392026335001,
-0.0006861677975393832,
0.03599778935313225,
-0.007820871658623219,
-0.039277300238609314,
0.0007217972888611257,
0.046502482146024704,
0.004182660952210426,
-0.0005748756811954081,
0.014206956140697002,
-0.0046022082678973675,
-0.004048150032758713,
-0.005370844155550003,
0.006072224583476782,
-0.02767089754343033,
-0.00935814343392849,
-0.011126006953418255,
-0.010741688311100006,
0.016551295295357704,
-0.0024131969548761845,
0.009274874813854694,
0.015014024451375008,
-0.010773715563118458,
0.0035837655887007713,
-0.020727552473545074,
-0.014770622365176678,
-0.005332412663847208,
-0.02738906443119049,
-0.028900714591145515,
0.009172390215098858,
0.012522362172603607,
0.019254332408308983,
0.013643289916217327,
-0.01176013145595789,
-0.003156211692839861,
-0.017050908878445625,
-0.030053669586777687,
-0.00849983375519514,
-0.002568525495007634,
0.001321893883869052,
-0.013592047616839409,
-0.011164438910782337,
-0.06159336864948273,
-0.027312200516462326,
0.01448878925293684,
0.006783213000744581,
-0.039149194955825806,
0.02305908128619194,
-0.025057535618543625,
-0.03955913335084915,
0.023763664066791534,
0.026338595896959305,
-0.00386239611543715,
0.028388291597366333,
-0.05093494802713394,
0.005902484524995089,
-0.02708161063492298,
0.01619260013103485,
-0.0209965743124485,
-0.027158474549651146,
0.004695085342973471,
0.003801545826718211,
-0.006892103236168623,
-0.028439532965421677,
-0.03276951611042023,
0.0034268356394022703,
-0.03725322708487511,
0.03479359298944473,
0.00992821529507637,
-0.0011569573543965816,
-0.008563886396586895,
0.008941799402236938,
-0.010895416140556335,
0.012618442066013813,
0.015526448376476765,
0.03950789198279381,
-0.006017779931426048,
0.041890665888786316,
-0.03438365086913109,
-0.027107231318950653,
-0.010299722664058208,
0.020061401650309563,
-0.016935614868998528,
-0.01168967317789793,
0.03312821313738823,
0.005652677733451128,
-0.0068280501291155815,
0.021995801478624344,
0.0013058806071057916,
-0.029669351875782013,
-0.012035559862852097,
-0.025339368730783463,
-0.016756266355514526,
0.02516002021729946,
-0.04176255688071251,
0.005492545198649168,
0.011824184097349644,
0.012913085520267487,
0.02161148376762867,
0.0004017324245069176,
-0.03415306285023689,
0.03253892436623573,
-0.02017669565975666,
-0.01792203076183796,
0.009575923904776573,
-0.015372720547020435,
-0.03136035054922104,
0.009672003798186779,
0.02451949007809162,
0.007961788214743137,
0.024942239746451378,
0.005425289273262024,
-0.03735571354627609,
-0.0007814466371200979,
-0.0169612355530262,
-0.022303255274891853,
0.012612036429345608,
-0.031437214463949203,
0.0028055214788764715,
0.01193947996944189,
0.027004746720194817,
-0.0073404740542173386,
0.014130092225968838,
0.02451949007809162,
-0.013515183702111244,
0.02147056721150875,
-0.010927442461252213,
-0.005912092048674822,
-0.027645276859402657,
0.0012482329038903117,
0.11427056044340134,
0.011817779392004013,
0.006917724385857582,
0.01601325161755085,
-0.016051683574914932,
-0.0008591109071858227,
-0.005985753145068884,
0.00832048524171114,
0.0010456652380526066,
-0.02097095362842083,
0.020227938890457153,
0.019420871511101723,
0.032410819083452225,
-0.01177934743463993,
0.010459855198860168,
-0.014514410868287086,
0.006113859359174967,
0.00882009882479906,
-0.002502871211618185,
0.00928768515586853,
0.009659192524850368,
0.020099831745028496,
-0.03853428736329079,
0.011254113167524338,
-0.005153064150363207,
-0.008807288482785225,
0.020061401650309563,
0.015910767018795013,
-0.0013082826044410467,
-0.0016101323999464512,
0.030386745929718018,
0.013656100258231163,
0.021713968366384506,
-0.02414798177778721,
-0.001441993284970522,
-0.0020128656178712845,
-0.011817779392004013,
-0.0307198204100132,
-0.013156486675143242,
0.014014797285199165,
-0.0025941466446965933,
0.014475978910923004,
-0.022815680131316185,
-0.0024996683932840824,
0.02499348297715187,
-0.006094643380492926,
-0.04022528603672981,
0.0034908887464553118,
0.014783433638513088,
-0.001018442795611918,
-0.008615128695964813,
0.0053163995034992695,
0.0009447818156331778,
0.016909992322325706,
-0.030002426356077194,
-0.028567640110850334,
0.008442185819149017,
-0.00825002696365118,
-0.014206956140697002,
-0.01635913737118244,
-0.014514410868287086,
0.013246160931885242,
-0.0011177249252796173,
-0.003907233010977507,
0.017191825434565544
] | 2025-01-18 | 9 | 39825416 | [
"Bridging therapy",
"CAR therapy",
"different bridging strategies",
"bridging regimens",
"high-intensity bridging therapy",
"Anti-CD19 chimeric antigen receptor T cells",
"Patients",
"patients",
"no systemic bridging therapy",
"CAR infusion",
"bacterial adverse events",
"more adverse events",
"any bridging therapy",
"a high-intensity bridging therapy",
"clinical outcome",
"Overall survival",
"CAR",
"young adults",
"outcome",
"side effects",
"disease",
"a low-intensity therapy",
"tumor burden and disease kinetics",
"comparison",
"93 2nd-generation CAR therapies",
"a low-intensity bridging regimen",
"relapsed/refractory B-lineage acute lymphoblastic leukemia",
"3) high-intensity therapy",
"children",
"2) low-intensity therapy"
] | [
"B-ALL",
"Bridging therapy",
"CAR T cells"
] | 0 | 10.1186/s13045-024-01659-x | [
"Breidenbach",
"Bader",
"Attarbaschi",
"Rossig",
"Meisel",
"Metzler",
"Subklewe",
"Mueller",
"Schlegel",
"Teichert von Lüttichau",
"Bourquin",
"Escherich",
"Cario",
"Lang",
"Coffey",
"von Stackelberg",
"Willier",
"Strahm",
"Peters",
"Feuchtinger"
] | [
"Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany.\nDepartment of Pediatric Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Dr. Von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.",
"Department of Pediatrics, Division for Stem Cell Transplantation, Immunology and Intensive Care, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.",
"Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Vienna, Austria.",
"Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany.",
"Division of Pediatric Stem Cell Therapy, Department of Pediatric Oncology, Hematology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany.",
"Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany.\nDepartment of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.",
"Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany.\nDepartment of Medicine III, LMU University Hospital, LMU Munich, Muenchen, Bavaria, Germany.",
"Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany.\nDepartment of Internal Medicine 5, Hematology and Oncology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Bavaria, Germany.",
"Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany.\nPediatric Hematology and Oncology and Stem Cell Transplantation, University Children's Hospital Wuerzburg, Würzburg, Germany.",
"Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany.\nDepartment of Pediatrics and Children's Cancer Research Center, TUM School of Medicine, Children's Hospital Munich Schwabing, Technical University of Munich, Munich, Germany.",
"Department of Oncology and Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.",
"Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.",
"Department of Pediatrics I, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.",
"Department of General Pediatrics, Hematology and Oncology, University Children's Hospital Tübingen, Tübingen, Germany.",
"Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany.\nDepartment of Pediatric Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Dr. Von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany.",
"Department of Pediatric Oncology and Hematology, Charité Universitaetsmedizin Berlin, Berlin, Germany.",
"Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.",
"Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.",
"Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital, Vienna, Austria.",
"Bavarian Cancer Research Center (BZKF), R/R ALL Study Group, Bavaria, Germany. [email protected].\nDepartment of Pediatric Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Dr. Von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany. [email protected].\nDepartment of Pediatric Hematology, Oncology and Stem Cell Transplantation, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. [email protected]."
] | [
"39825416",
"29385370",
"36607834",
"34882493",
"29385376",
"25317870",
"28924019",
"31650176",
"38356450"
] | [] | 6.480481 | 5.460928 |
39824562 | 16 | Retrovirus-based manufacturing of chimeric antigen receptor-modified T cells for cancer therapy research. | Treatment with autologous chimeric antigen receptor (CAR)-modified T cells can achieve outstanding clinical response rates in heavily pretreated patients with B and plasma cell malignancies. However, relapses occur, and they limit the efficacy of this promising treatment approach. The complex GMP-compliant production and high treatment costs cause that CAR T cells cannot yet be used in a broad population. Among others, CAR T cell therapy has evolved regarding vector design and manufacturing process. Optimal production of CAR T cells is not yet defined, far from being standardized. Quality, cellular composition and immunophenotype of the administered CAR T cells are influenced by the manufacturing protocol and therefore play a crucial role for therapeutic success. For the gene transfer, viral and non-viral strategies are available. Retrovirus-based protocols for CAR T cell production offer advantages in terms of stable gene integration, sufficient transduction efficiency, proven clinical success, and scalability. Here, we detail a retrovirus-based generation protocol of human CAR-modified T cells for experimental immunotherapeutic treatment of cancer cells. For the CAR generation, HEK-293-based packaging cell lines, CD3 | [
0.008551987819373608,
0.014783762395381927,
0.057580143213272095,
0.02990766055881977,
-0.036248765885829926,
-0.03809521719813347,
0.022886283695697784,
0.01684887334704399,
0.0037414943799376488,
-0.015779875218868256,
-0.00008247156074503437,
-0.014455773867666721,
-0.021914467215538025,
-0.005943266674876213,
-0.006413990631699562,
-0.06064136326313019,
0.04516518488526344,
0.0007789718802087009,
-0.0031371458899229765,
0.021756546571850777,
0.04069482535123825,
0.02609327994287014,
-0.016703100875020027,
0.0050443364307284355,
-0.051603469997644424,
0.0023976541124284267,
0.008321180939674377,
0.009627060033380985,
-0.03870260342955589,
-0.06049559265375137,
-0.010489546693861485,
-0.023420782759785652,
-0.011151596903800964,
-0.0405004620552063,
-0.002605683635920286,
0.03138967975974083,
0.05223514884710312,
0.00019369901565369219,
-0.007981045171618462,
-0.008886049501597881,
0.05097178742289543,
0.015439738519489765,
0.02844993583858013,
0.08566564321517944,
-0.03773078694939613,
0.009481287561357021,
-0.0195456650108099,
-0.045602500438690186,
-0.00886782817542553,
-0.0076894997619092464,
-0.042468391358852386,
-0.005484690889716148,
-0.04985420033335686,
0.030733704566955566,
-0.05315837636590004,
0.05223514884710312,
-0.04742465540766716,
0.009870014153420925,
-0.016423702239990234,
0.03304176777601242,
0.02755100466310978,
-0.007774534169584513,
0.017990756779909134,
-0.05388723686337471,
-0.038386762142181396,
0.0027362715918570757,
-0.05777450650930405,
-0.011619283817708492,
-0.002525205025449395,
0.03136538714170456,
0.01709182746708393,
-0.018513109534978867,
0.0052903275936841965,
-0.014467922039330006,
0.015160340815782547,
0.023773066699504852,
0.002452318789437413,
0.019181232899427414,
0.03802233189344406,
0.006711609195917845,
0.003264696802943945,
-0.015743430703878403,
0.007361511699855328,
-0.06287654489278793,
-0.003401358611881733,
-0.04334302619099617,
0.007185370195657015,
-0.029373161494731903,
-0.03442660719156265,
-0.0232264194637537,
-0.022400375455617905,
0.02565596252679825,
-0.04594263806939125,
0.062342043966054916,
-0.009505582973361015,
0.008928566239774227,
-0.0075558749958872795,
-0.02287413738667965,
0.027842549607157707,
0.03449949622154236,
0.055442146956920624,
0.01462584175169468,
-0.003121961373835802,
0.01627792976796627,
0.03972300887107849,
-0.013593286275863647,
-0.07682211697101593,
0.020760435611009598,
0.024781327694654465,
-0.009778905659914017,
0.06661804020404816,
-0.018051495775580406,
-0.013848388567566872,
0.06103008985519409,
-0.02219386398792267,
-0.04980560764670372,
-0.013848388567566872,
0.004118073265999556,
0.006280365865677595,
0.0447278656065464,
-0.015111749991774559,
0.006049559451639652,
0.045359548181295395,
-0.022448966279625893,
0.007233961019665003,
-0.022558296099305153,
0.07468411326408386,
-0.021586479619145393,
-0.038921259343624115,
-0.05811464041471481,
0.025485893711447716,
0.006626575253903866,
0.01534255687147379,
-0.01437074039131403,
-0.05213796719908714,
0.004026965703815222,
-0.016775986179709435,
0.038411058485507965,
-0.042031075805425644,
-0.01486879587173462,
0.013386775739490986,
-0.008892123587429523,
-0.028401345014572144,
0.0003109054232481867,
-0.02633623406291008,
-0.026530597358942032,
-0.015172488987445831,
0.03202136233448982,
0.006644797045737505,
0.045869749039411545,
-0.032920293509960175,
0.04914963245391846,
0.029640410095453262,
0.019642846658825874,
-0.0006760959513485432,
-0.05558791756629944,
-0.01892613060772419,
0.0471574068069458,
-0.026141870766878128,
-0.039382874965667725,
-0.0204445943236351,
0.006298587191849947,
-0.03717198967933655,
-0.046525727957487106,
0.017747802659869194,
-0.006125482264906168,
-0.027356641367077827,
0.016581622883677483,
-0.06734690070152283,
-0.012840128503739834,
-0.006577984429895878,
-0.02609327994287014,
-0.07784251868724823,
-0.010896495543420315,
-0.053741466253995895,
0.009590616449713707,
-0.014054900035262108,
0.017662769183516502,
-0.024234680458903313,
-0.04805633798241615,
0.01998298242688179,
0.03357626870274544,
0.043950412422418594,
-0.008770646527409554,
-0.026992209255695343,
0.018294449895620346,
-0.03814380615949631,
-0.006134593393653631,
-0.029348865151405334,
-0.02038385532796383,
0.0176263265311718,
-0.014820205047726631,
0.02704080007970333,
-0.004367101471871138,
0.013678320683538914,
0.0003040723386220634,
0.05573369190096855,
0.02338434010744095,
-0.002215438522398472,
-0.03323613107204437,
0.01709182746708393,
-0.0394800566136837,
-0.037755079567432404,
-0.008545913733541965,
-0.037196286022663116,
-0.04149657487869263,
-0.008533765561878681,
0.031924180686473846,
-0.01716471277177334,
-0.012421032413840294,
0.03442660719156265,
-0.008351550437510014,
-0.034086473286151886,
0.03743923828005791,
-0.04674438387155533,
-0.034791041165590286,
-0.012056601233780384,
0.06268218159675598,
0.01509960275143385,
0.028401345014572144,
-0.03814380615949631,
-0.015779875218868256,
-0.038945555686950684,
0.011625357903540134,
-0.011443141847848892,
0.009019673801958561,
0.017152566462755203,
-0.026384824886918068,
0.01027696207165718,
-0.035957220941782,
-0.018634585663676262,
-0.0016475330339744687,
0.011437068693339825,
-0.03272593021392822,
-0.043027184903621674,
-0.015986384823918343,
0.05408160015940666,
0.01854955218732357,
0.04907674714922905,
-0.016314374282956123,
0.004266882780939341,
0.026044689118862152,
-0.0042516980320215225,
-0.03309036046266556,
-0.006492950487881899,
-0.024866361171007156,
-0.010283036157488823,
-0.059232231229543686,
0.01714041829109192,
-0.018646733835339546,
0.009699946269392967,
-0.013010196387767792,
-0.005220477934926748,
0.002013482851907611,
0.04047616571187973,
0.013362480327486992,
0.02441689558327198,
-0.03350338339805603,
0.01941203884780407,
-0.029105911031365395,
-0.021379968151450157,
0.003328472375869751,
-0.04674438387155533,
-0.0035805373918265104,
-0.032920293509960175,
0.05408160015940666,
0.01051991619169712,
0.006577984429895878,
0.0215014461427927,
-0.00004284914757590741,
0.023918839171528816,
-0.02192661538720131,
0.06370259076356888,
-0.0020514444913715124,
-0.06720113009214401,
-0.007227886933833361,
-0.000021246627511573024,
0.0349368117749691,
-0.01557336375117302,
0.013909127563238144,
-0.01835518889129162,
0.02206023968756199,
-0.0038356392178684473,
-0.0032616599928587675,
-0.022327490150928497,
-0.014941682107746601,
0.03087947703897953,
0.009839644655585289,
0.016107862815260887,
-0.04878520220518112,
0.028134094551205635,
0.0049471547827124596,
-0.01841592788696289,
-0.018962575122714043,
0.013386775739490986,
0.0017021977109834552,
-0.021489297971129417,
0.01601068116724491,
-0.0349368117749691,
0.002066629007458687,
-0.028182685375213623,
0.02704080007970333,
-0.006565836723893881,
-0.0263605285435915,
-0.02117345668375492,
0.009092560037970543,
-0.02947034314274788,
-0.0084608793258667,
0.021428558975458145,
0.036005809903144836,
0.026749255135655403,
0.022813398391008377,
0.031000955030322075,
0.00010097783524543047,
-0.004555391147732735,
0.03814380615949631,
-0.007106409873813391,
-0.044412024319171906,
0.018428074195981026,
-0.0603984110057354,
-0.048979565501213074,
-0.012499992735683918,
-0.009402327239513397,
0.021537888795137405,
0.006210516206920147,
-0.0356413796544075,
0.005487727466970682,
-0.03967441990971565,
0.04601552337408066,
-0.004804418887943029,
0.005211367271840572,
-0.040111735463142395,
0.05204078555107117,
-0.011230557225644588,
0.011345960199832916,
0.0048469360917806625,
-0.019946537911891937,
-0.04914963245391846,
0.03610299155116081,
-0.019472777843475342,
-0.007276477757841349,
0.021209901198744774,
-0.011807573027908802,
0.07439257204532623,
-0.0021577368024736643,
0.005332844331860542,
-0.01231777761131525,
0.028401345014572144,
0.008181482553482056,
0.015694839879870415,
0.007774534169584513,
0.030733704566955566,
0.024380452930927277,
-0.004342806059867144,
0.010677836835384369,
0.02825557254254818,
-0.006784495431929827,
-0.00016646158474031836,
-0.019375596195459366,
-0.014844500459730625,
0.02276480756700039,
0.04351309314370155,
-0.02384595386683941,
0.023420782759785652,
0.042298324406147,
0.07628761231899261,
-0.02362729422748089,
0.06350822746753693,
-0.008667390793561935,
-0.047011636197566986,
-0.0037749006878584623,
-0.04518947750329971,
0.005341954994946718,
0.0076166135258972645,
-0.05097178742289543,
0.006231775041669607,
0.0314139761030674,
0.024781327694654465,
-0.0051688505336642265,
-0.009548099711537361,
0.0405004620552063,
-0.025194348767399788,
-0.0338435173034668,
-0.0258503258228302,
-0.01627792976796627,
0.014455773867666721,
0.005454321391880512,
0.017456257715821266,
-0.07215739041566849,
0.0352526530623436,
-0.004801382310688496,
-0.0195456650108099,
-0.006693387869745493,
-0.015002421103417873,
-0.026676369830965996,
0.06613212823867798,
-0.03610299155116081,
0.07035953551530838,
0.025315826758742332,
0.01768706552684307,
0.018233710899949074,
-0.03969871252775192,
-0.036005809903144836,
-0.025072872638702393,
0.015281817875802517,
-0.020663253962993622,
0.018671028316020966,
0.03420795127749443,
0.017772099003195763,
-0.0076166135258972645,
0.012718651443719864,
-0.007057819049805403,
0.025753144174814224,
-0.015427591279149055,
-0.004922859370708466,
-0.004564501810818911,
-0.027818255126476288,
0.020857617259025574,
-0.00254190806299448,
0.04118073359131813,
0.022096682339906693,
-0.03824098780751228,
0.001852525630965829,
-0.008819237351417542,
-0.029275979846715927,
-0.010659614577889442,
0.013228855095803738,
0.013010196387767792,
-0.05869773030281067,
-0.03428083658218384,
-0.029543228447437286,
0.031049545854330063,
-0.0016854946734383702,
-0.010380217805504799,
-0.013119526207447052,
0.04110784828662872,
-0.04650143161416054,
-0.0352526530623436,
-0.027429528534412384,
0.05461610108613968,
-0.01938774436712265,
0.014237115159630775,
0.0037597159389406443,
-0.03134109079837799,
0.029591819271445274,
0.021647218614816666,
-0.002997447270900011,
0.035544198006391525,
-0.033406201750040054,
-0.03335760906338692,
-0.020784730091691017,
-0.007476915139704943,
-0.004233476705849171,
-0.017322633415460587,
-0.030515044927597046,
-0.019290562719106674,
0.03202136233448982,
-0.04929540306329727,
-0.00802963599562645,
0.02198735438287258,
0.003099184250459075,
-0.024052465334534645,
0.011522102169692516,
-0.012888719327747822,
-0.011831868439912796,
0.03809521719813347,
0.04074341803789139,
-0.025315826758742332,
0.009438769891858101,
-0.05296401306986809,
0.013265298679471016,
-0.012366368435323238,
-0.015476182103157043,
-0.001417485880665481,
-0.0021972169633954763,
0.03833816945552826,
0.00020214547112118453,
0.004169701132923365,
0.018974721431732178,
0.011625357903540134,
0.018622437492012978,
0.014601546339690685,
-0.010556359775364399,
-0.007264330051839352,
0.025242939591407776,
0.05850336700677872,
-0.0015822391724213958,
-0.021647218614816666,
-0.042541276663541794,
0.02278910204768181,
0.014152081683278084,
-0.007355438079684973,
0.005594020243734121,
-0.011673948727548122,
-0.01051991619169712,
0.010562432929873466,
-0.038896966725587845,
0.003975337836891413,
-0.01161320973187685,
0.03323613107204437,
-0.0008928566239774227,
0.04064623638987541,
-0.017322633415460587,
0.018986869603395462,
0.04438772797584534,
0.04742465540766716,
0.027429528534412384,
0.06836730986833572,
-0.00553631829097867,
0.026141870766878128,
-0.036758966743946075,
0.004591834265738726,
0.021452855318784714,
-0.019679289311170578,
-0.0338435173034668,
-0.01594994217157364,
-0.051797833293676376,
-0.02000727690756321,
-0.028134094551205635,
-0.009888235479593277,
-0.019327005371451378,
-0.025340121239423752,
-0.0036898667458444834,
0.01630222611129284,
-0.014662285335361958,
-0.022206012159585953,
-0.027210868895053864,
-0.036758966743946075,
-0.028134094551205635,
-0.031997065991163254,
0.042978595942258835,
0.009517730213701725,
0.0006430693902075291,
-0.008521618321537971,
-0.034110765904188156,
-0.01450436469167471,
-0.034596677869558334,
0.037755079567432404,
-0.012427106499671936,
-0.04212825745344162,
0.00985786598175764,
0.0051658134907484055,
0.011461364105343819,
-0.00525995809584856,
-0.004506800323724747,
0.0010727945482358336,
0.018877539783716202,
-0.010623171925544739,
0.0123967370018363,
0.006256070453673601,
0.035082586109638214,
-0.022910580039024353,
0.02541300840675831,
-0.013471809215843678,
0.01238458976149559,
-0.02303205616772175,
-0.013678320683538914,
-0.009511656127870083,
-0.00862487405538559,
-0.018962575122714043,
-0.01178935170173645,
-0.011084784753620625,
0.031972769647836685,
-0.01269435603171587,
-0.02190231904387474,
0.035762857645750046,
0.001633866922929883,
-0.021185604855418205,
-0.03658889979124069,
0.012755095027387142,
-0.019703583791851997,
0.005460395477712154,
0.018622437492012978,
-0.018537404015660286,
0.03804662451148033,
0.021756546571850777,
-0.0017021977109834552,
-0.010702132247388363,
-0.0207968782633543,
0.029883364215493202,
-0.025510190054774284,
-0.029130207374691963,
-0.005654758773744106,
0.03850824013352394,
-0.005250847432762384,
0.016690952703356743,
-0.04341591149568558,
0.009535951539874077,
-0.01751699671149254,
0.012463550083339214,
0.03590862825512886,
0.03972300887107849,
0.023675885051488876,
0.0028941917698830366,
-0.0433187298476696,
0.02452622540295124,
-0.001441781292669475,
-0.0035197988618165255,
-0.02457481622695923,
0.007136779371649027,
-0.016423702239990234,
0.0034165431279689074,
-0.015804169699549675,
-0.0415937565267086,
-0.0332118384540081,
0.04312436655163765,
-0.013593286275863647,
-0.013143821619451046,
-0.003635202068835497,
-0.0033679523039609194,
0.05286683142185211,
0.022181717678904533,
-0.035811446607112885,
0.009766758419573307,
0.0309037733823061,
0.028182685375213623,
-0.020869765430688858,
-0.013629729859530926,
0.012178078293800354,
-0.02755100466310978,
-0.012129487469792366,
0.02560737170279026,
-0.01545188669115305,
0.00022644089767709374,
-0.0037475682329386473,
-0.020420299842953682,
-0.008564135059714317,
0.0051172226667404175,
-0.0050534470938146114,
0.021404264494776726,
-0.005676017142832279,
-0.025971801951527596,
-0.00816326029598713,
0.02300776168704033,
-0.008916418999433517,
-0.018634585663676262,
0.018002904951572418,
-0.02684643678367138,
0.006274291779845953,
-0.003829565364867449,
-0.01034377422183752,
0.03972300887107849,
-0.005114185623824596,
-0.02896013855934143,
0.015378999523818493,
-0.020031573250889778,
-0.031195318326354027,
0.0004843899223487824,
0.019023312255740166,
-0.006863455753773451,
0.00407555652782321,
-0.01565839722752571,
0.019825061783194542,
-0.031997065991163254,
-0.003817417658865452,
-0.024404747411608696,
-0.003228253684937954,
0.0038326021749526262,
0.060446999967098236,
0.08095233142375946,
-0.020723992958664894,
0.03039356879889965,
-0.0021121830213814974,
-0.013872683979570866,
0.017371224239468575,
-0.019156938418745995,
-0.012111266143620014,
0.015585510991513729,
-0.019509220495820045,
0.021015537902712822,
0.08338187634944916,
0.034791041165590286,
-0.016338668763637543,
-0.038435351103544235,
-0.023639442399144173,
-0.01751699671149254,
0.003073370549827814,
-0.040378984063863754,
0.00482567772269249,
0.01806364394724369,
-0.014759466983377934,
0.009001452475786209,
-0.047740496695041656,
-0.040549054741859436,
0.01868317648768425,
-0.02000727690756321,
0.011916902847588062,
0.00023289436649065465,
0.0020878876093775034,
0.017857132479548454,
-0.0004885657108388841,
-0.018367337062954903,
-0.028862956911325455,
0.003033890388906002,
0.02258259244263172,
0.015306113287806511,
-0.021780842915177345,
-0.014030604623258114,
-0.010702132247388363,
-0.01760203018784523,
0.02609327994287014,
0.01280368585139513,
0.04426625370979309,
-0.02893584407866001,
0.0356413796544075,
-0.008060005493462086,
-0.031073840335011482,
-0.016460146754980087,
0.013581139035522938,
0.027623891830444336,
0.015366852283477783,
0.022776955738663673,
-0.03644312918186188,
-0.030004842206835747,
-0.005946303717792034,
0.01485664863139391,
-0.00607689144089818,
0.041763823479413986,
0.03226431459188461,
0.020481036975979805,
0.0010879791807383299,
0.04696304351091385,
-0.03326042741537094,
0.017857132479548454,
0.015415443107485771,
0.021428558975458145,
-0.04285711795091629,
0.07988333702087402,
-0.02779395878314972,
-0.014759466983377934,
0.005761051084846258,
-0.029859069734811783,
-0.015852760523557663,
-0.006978859193623066,
-0.0125728789716959,
0.04494652524590492,
-0.03449949622154236,
-0.018719619140028954,
-0.001378005719743669,
-0.0015746467979624867,
0.010404513217508793,
-0.012657913379371166,
-0.024003874510526657,
0.01835518889129162,
-0.011260926723480225,
0.01868317648768425,
0.03551990166306496,
0.010119041427969933,
0.00682701263576746,
-0.02896013855934143,
0.00246446649543941,
0.008977157063782215,
-0.031073840335011482,
-0.03709910437464714,
0.006316808983683586,
-0.03994166851043701,
0.012609322555363178,
-0.006007042247802019,
-0.03355197235941887,
-0.0263605285435915,
-0.036005809903144836,
-0.004294215235859156,
-0.004740643780678511,
0.006699461489915848,
-0.0012542509939521551,
-0.011594988405704498,
0.010082598775625229,
0.01930271089076996,
-0.008315106853842735,
0.035301242023706436,
-0.029397455975413322,
0.002646682085469365,
0.0041909595020115376,
-0.007112483959645033,
0.008406214416027069,
-0.0025920174084603786,
-0.013010196387767792,
0.018367337062954903,
-0.006486876867711544,
-0.016909610480070114,
-0.01751699671149254,
-0.0011039230739697814,
-0.04591834172606468,
0.017480554059147835,
-0.02869288995862007,
0.023991726338863373,
-0.010617097839713097,
0.034572381526231766,
-0.014965977519750595,
-0.005688164848834276,
-0.009068264625966549,
0.030806591734290123,
-0.016812428832054138,
0.03617587685585022,
-0.020347412675619125,
-0.0050321887247264385,
0.03707480803132057,
-0.07623902708292007,
-0.020213788375258446,
-0.0017644547624513507,
-0.00832725502550602,
0.003094628918915987,
-0.0038781561888754368,
-0.024344010278582573,
0.010847904719412327,
-0.005809641908854246,
-0.000964224454946816,
-0.00804178323596716,
-0.021452855318784714,
0.023262863978743553,
-0.005779272876679897,
0.003425654023885727,
-0.008315106853842735,
-0.026409119367599487,
-0.062390636652708054,
0.00013049297558609396,
0.030296387150883675,
-0.01166787464171648,
-0.0006244682008400559,
-0.015852760523557663,
0.02755100466310978,
0.004303325898945332,
-0.005311585962772369,
-0.008831384591758251,
-0.008618799969553947,
-0.047546133399009705,
-0.015597659163177013,
0.018585994839668274,
0.02000727690756321,
-0.03401358425617218,
0.02263118326663971,
-0.015937793999910355,
-0.040354691445827484,
0.026287643238902092,
-0.023566555231809616,
0.006152814719825983,
0.025048576295375824,
0.004306362941861153,
-0.010495620779693127,
0.013228855095803738,
0.027575301006436348,
-0.00832725502550602,
-0.014091342687606812,
-0.00271805003285408,
-0.008302959613502026,
-0.003118924330919981,
-0.013860536739230156,
0.040087439119815826,
-0.03284740447998047,
-0.009809275157749653,
0.0086370212957263,
0.009523804299533367,
-0.0012891757069155574,
-0.01202015858143568,
0.010331626981496811,
-0.005208330228924751,
0.004752791486680508,
-0.008290811441838741,
0.053255558013916016,
0.048032041639089584,
-0.024744883179664612,
-0.0024189127143472433,
-0.0352526530623436,
-0.042978595942258835,
0.031049545854330063,
-0.047740496695041656,
0.03401358425617218,
-0.026676369830965996,
0.02541300840675831,
-0.03275022283196449,
0.03695333003997803,
-0.02144070714712143,
0.03114672750234604,
-0.022108830511569977,
0.0074951364658772945,
0.019241971895098686,
0.007288625463843346,
-0.022291047498583794,
-0.023894544690847397,
-0.007306847255676985,
-0.007045671343803406,
-0.03717198967933655,
0.014480069279670715,
-0.003231290727853775,
-0.0025267235469073057,
0.026433415710926056,
-0.006450433749705553,
-0.003401358611881733,
-0.014990272931754589,
-0.014188524335622787,
-0.009098634123802185,
0.005238699726760387,
-0.010210149921476841,
-0.04375604912638664,
0.0017583809094503522,
-0.0044733937829732895,
-0.02020164020359516,
0.024404747411608696,
-0.041788119822740555,
0.009505582973361015,
-0.04832358658313751,
-0.02728375419974327,
-0.017504848539829254,
0.05680269002914429,
-0.016484441235661507,
0.005715497303754091,
-0.01903546042740345,
0.02565596252679825,
-0.000905763590708375,
0.0387754887342453,
-0.0041666640900075436,
-0.0005269068642519414,
0.02517005428671837,
0.03134109079837799,
-0.003780974540859461,
0.01366617251187563,
0.000704946753103286,
0.07808547466993332,
0.02536441758275032,
-0.0008738758624531329,
-0.04062194004654884,
-0.02241252362728119,
-0.030976658686995506,
-0.006237848661839962,
0.022776955738663673,
0.0053267707116901875,
-0.008345476351678371,
0.010198001749813557,
-0.0045857601799070835,
0.02490280382335186,
-0.005147591698914766,
-0.02155003696680069,
0.03464526683092117,
0.011941198259592056,
0.014965977519750595,
-0.006571910809725523,
0.017638474702835083,
0.0017128270119428635,
-0.02046889066696167,
0.0006119408644735813,
-0.02444119192659855,
0.025437302887439728,
-0.009299071505665779,
-0.054275963455438614,
0.03955294191837311,
-0.006851308047771454,
0.005071668419986963,
-0.013520400039851665,
0.05043729022145271,
0.018804654479026794,
0.06365399807691574,
-0.011188040487468243,
0.012499992735683918,
0.011916902847588062,
-0.003449949435889721,
-0.015123898163437843,
0.02823127619922161,
-0.004048224072903395,
0.06331386417150497,
-0.023347897455096245,
-0.033867813646793365,
0.01069605816155672,
-0.02750241383910179,
-0.009991491213440895,
0.014346444979310036,
0.032410088926553726,
0.008606651797890663,
0.01412778627127409,
-0.048250701278448105,
0.036734674125909805,
-0.01185616385191679,
-0.007762386463582516,
0.0025753143709152937,
0.029616115614771843,
0.014516512863337994,
0.02631193771958351,
0.033430494368076324,
-0.03398929163813591,
-0.0007763145258650184,
-0.0018540441524237394,
0.032944586127996445,
0.021319229155778885,
-0.008363697677850723,
-0.007634835317730904,
-0.027113687247037888,
0.022947022691369057,
0.005931118968874216,
-0.02422253228724003,
-0.03155975043773651,
0.005730682052671909,
0.06268218159675598,
0.017395520582795143,
-0.01989794708788395,
-0.02538871206343174,
-0.003452986478805542,
-0.029081616550683975,
-0.019241971895098686,
-0.04963554069399834,
0.025947507470846176,
0.015293966047465801,
-0.010161559097468853,
-0.014273558743298054,
0.017917871475219727,
0.00341350631788373,
-0.016581622883677483,
-0.016581622883677483,
0.033673450350761414,
0.017504848539829254,
0.04931969940662384,
-0.027356641367077827,
0.016994645819067955,
-0.003452986478805542,
-0.019825061783194542,
0.012014084495604038,
0.0008602096932008862,
-0.04290571063756943,
-0.023129237815737724,
-0.050145745277404785,
-0.014844500459730625,
-0.007337216287851334,
-0.020614663138985634,
-0.017893575131893158,
0.02284984104335308,
0.028668593615293503,
0.030733704566955566,
0.00616496242582798,
0.007847419939935207,
-0.0207968782633543,
0.0008670427487231791,
0.031486861407756805,
-0.0026284605264663696,
-0.006237848661839962,
-0.002871414879336953,
-0.018318746238946915,
-0.03041786327958107,
-0.00416362751275301,
-0.022813398391008377,
0.047327473759651184,
0.026773551478981972,
0.015488329343497753,
-0.03534983471035957,
-0.019448483362793922,
-0.007106409873813391,
0.035811446607112885,
-0.02146500162780285,
-0.00992467813193798,
0.00329202925786376,
-0.04650143161416054,
0.008072152733802795,
0.02798832207918167,
0.03787655755877495,
0.05787168815732002,
0.01076287031173706,
0.0047588651068508625,
0.02512146346271038,
0.009706019423902035,
-0.00374453142285347,
-0.009171520359814167,
0.006280365865677595,
0.034839630126953125,
-0.01366617251187563,
0.044630683958530426,
-0.010847904719412327,
0.01208697073161602,
-0.015403295867145061,
-0.007106409873813391,
0.013848388567566872,
0.021695809438824654,
0.022133126854896545,
0.0023490632884204388,
0.016775986179709435,
0.006353252101689577,
-0.006383621133863926,
0.019023312255740166,
-0.00731292087584734,
-0.00815111305564642,
0.007896010763943195,
-0.030806591734290123,
-0.007549801375716925,
-0.04071912169456482,
0.009092560037970543,
0.01711612194776535,
0.006486876867711544,
-0.011904754675924778,
0.00025491209817118943,
-0.0024963542819023132,
-0.01243925467133522,
-0.005150628741830587,
0.004989671520888805,
-0.02276480756700039,
-0.02492710016667843,
0.002456874120980501,
-0.006790569517761469,
0.008260441944003105,
-0.011686095967888832,
0.009317292831838131,
0.001163902343250811,
0.03646742179989815,
0.03279881551861763,
0.007076040841639042,
-0.03265304118394852,
0.020784730091691017,
-0.015184636227786541,
-0.014237115159630775,
-0.05058306083083153,
0.05432455614209175,
-0.011449215933680534,
-0.04327014088630676,
0.02708939090371132,
-0.009499508887529373,
-0.025024281814694405,
0.019229823723435402,
0.02657918818295002,
-0.02465984970331192,
0.007586244493722916,
0.003024779725819826,
0.008600578643381596,
-0.030223499983549118,
0.00037240321398712695,
-0.01437074039131403,
-0.004045187029987574,
-0.03921280428767204,
-0.020626811310648918,
0.0020271490793675184,
0.014480069279670715,
-0.00350157730281353,
-0.01976432278752327,
0.01841592788696289,
-0.008606651797890663,
0.017055382952094078,
0.016180748119950294,
0.012044453993439674,
-0.001633866922929883,
-0.00230806483887136,
-0.021003389731049538,
0.0031766260508447886,
-0.0033223985228687525,
-0.007440472021698952,
-0.010598876513540745,
0.0036382388789206743,
0.008248294703662395,
-0.0049835979007184505,
0.00862487405538559,
-0.01268220879137516,
0.01165572740137577,
-0.031486861407756805,
-0.005688164848834276,
0.0583575963973999,
-0.013909127563238144,
-0.05699705332517624,
0.05383864790201187,
0.00833940226584673,
-0.00350157730281353,
0.006656944751739502,
0.013581139035522938,
0.0021334413904696703,
-0.005855195689946413,
-0.004391396883875132,
0.016727395355701447,
0.038435351103544235,
-0.009542025625705719,
0.001163902343250811,
0.020991241559386253,
-0.01330174133181572,
-0.01711612194776535,
0.0008723573992028832,
-0.009214037097990513,
0.03860542178153992,
0.016836725175380707,
-0.01649658940732479,
0.025753144174814224,
0.0084608793258667,
0.03476674482226372,
0.024999985471367836,
0.01971573196351528,
0.0035076511558145285,
0.029057320207357407,
0.02414964698255062,
0.00816326029598713,
-0.007823124527931213,
-0.032677337527275085,
0.008831384591758251,
-0.030344977974891663,
-0.052283741533756256,
-0.049902789294719696,
-0.017541293054819107,
-0.013860536739230156,
-0.012597174383699894,
-0.0015108713414520025,
-0.011752909049391747,
0.007161074783653021,
-0.02582602947950363,
-0.026967914775013924,
-0.010015786625444889,
-0.004989671520888805,
-0.00522655202075839,
-0.002863822504878044,
-0.03858112543821335,
-0.0010948122944682837,
0.012250964529812336,
0.006669092457741499,
0.026384824886918068,
0.02417394146323204,
-0.014115638099610806,
-0.004030002746731043,
0.03114672750234604,
0.006918120663613081,
-0.010835756547749043,
-0.001441781292669475,
-0.06394553929567337,
0.01811223477125168,
-0.03469385951757431,
0.0011623839382082224,
-0.0015761653194203973,
-0.017699211835861206,
-0.042298324406147,
0.0024265048559755087,
0.02309279516339302,
0.001847970299422741,
0.0035926850978285074,
-0.0075923181138932705,
-0.00571246026083827,
0.0015928683569654822,
0.02049318514764309,
-0.007373659405857325,
-0.036516014486551285,
0.04521377384662628,
-0.013083082623779774,
0.0011737723834812641,
-0.006389695219695568,
-0.021780842915177345,
-0.039358578622341156,
0.020055867731571198,
-0.011163745075464249,
0.02025023102760315,
-0.01833089254796505,
0.024696292355656624,
-0.013872683979570866,
-0.02219386398792267,
0.0632166787981987,
0.01601068116724491,
-0.01316811703145504,
-0.013848388567566872,
-0.004357990808784962,
-0.008764572441577911,
0.0331389494240284,
0.03751212731003761,
0.016205044463276863,
0.029980545863509178,
-0.013204559683799744,
0.0030475566163659096,
-0.02995625138282776,
0.0049441177397966385,
-0.027891140431165695,
-0.014808057807385921,
0.006049559451639652,
0.022971319034695625,
-0.03712340071797371,
-0.006839160341769457,
-0.0050078933127224445,
0.03950434923171997,
-0.011394551023840904,
0.009572395123541355,
-0.002719568321481347,
-0.016229338943958282,
0.010447029955685139,
-0.01974002830684185,
0.006887751165777445,
0.010501694865524769,
0.028182685375213623,
-0.016399407759308815,
0.01927841454744339,
-0.019509220495820045,
0.05942659452557564,
0.00202107522636652,
0.009365883655846119,
-0.03974730521440506,
-0.010404513217508793,
0.0025722775608301163,
0.009335514158010483,
-0.008078226819634438,
0.03586003929376602,
0.044023297727108,
-0.020833320915699005,
-0.029980545863509178,
0.037196286022663116,
-0.01716471277177334,
-0.02152574062347412,
-0.01534255687147379,
-0.01616860181093216,
-0.0011244222987443209,
-0.010932938195765018,
-0.009274776093661785,
0.004600944928824902,
0.009870014153420925,
0.0017492701299488544,
-0.005873417481780052,
-0.0012557693989947438,
-0.0048226406797766685,
-0.004467320162802935,
-0.008782793767750263,
-0.0034681709948927164,
0.011692170053720474,
-0.049465473741292953,
-0.06695817410945892,
0.02468414604663849,
0.011995863169431686,
-0.016751691699028015,
-0.011686095967888832,
-0.027235163375735283,
0.011758982203900814,
0.04220114275813103,
-0.060204047709703445,
-0.0021258490160107613,
0.03476674482226372,
0.0044248029589653015,
-0.0011654208647087216,
0.008922492153942585,
0.021562183275818825,
0.03209424763917923,
0.002071184339001775,
-0.0032221798319369555,
0.0015685729449614882,
0.009122929535806179,
0.04020891711115837,
-0.015318261459469795,
0.017261894419789314,
0.017650621011853218,
-0.009620985947549343,
0.0012671579606831074,
-0.021209901198744774,
-0.017079679295420647,
0.04713311046361923,
-0.012536436319351196,
-0.00616496242582798,
-0.020019425079226494,
-0.006028300616890192,
-0.010525990277528763,
0.009323366917669773,
0.01268220879137516,
-0.010264814831316471,
0.022813398391008377,
0.014820205047726631,
0.031195318326354027,
-0.008983231149613857,
-0.002022593514993787,
0.021404264494776726,
0.018610291182994843,
0.005481653846800327,
-0.003951042424887419,
0.007634835317730904,
-0.015804169699549675,
-0.029591819271445274,
-0.011345960199832916,
-0.0003849305503536016,
-0.021562183275818825,
0.030612226575613022,
0.0045341323129832745,
-0.022266751155257225,
0.0015564252389594913,
0.02227889932692051,
0.01817297376692295,
-0.026992209255695343,
-0.01534255687147379,
-0.013022344559431076,
-0.00875849835574627,
0.005396619904786348,
-0.012670060619711876,
0.0026633853558450937,
-0.012670060619711876,
-0.003708088304847479,
-0.014467922039330006,
0.02752671018242836,
-0.004989671520888805,
0.0024948357604444027,
0.005803568288683891,
0.002610238967463374,
-0.030612226575613022,
0.02565596252679825,
-0.011959419585764408,
0.03561708331108093,
-0.03258015587925911,
-0.015196784399449825,
-0.03734205663204193,
-0.020432446151971817,
-0.007574096787720919,
0.0006248477729968727,
-0.04241980239748955,
0.008977157063782215,
-0.003659497480839491,
-0.02274051122367382,
0.019825061783194542,
0.02823127619922161,
0.003914599306881428,
0.01280368585139513,
-0.04431484267115593,
0.0030323718674480915,
0.014273558743298054,
0.0331389494240284,
-0.00792030617594719,
-0.005035225301980972,
-0.010738574899733067,
-0.020286673679947853,
-0.0004418729222379625,
-0.043731752783060074,
-0.03369774669408798,
0.010052229277789593,
-0.004877305123955011,
-0.018282301723957062,
-0.0075558749958872795,
-0.02433186210691929,
-0.004175775218755007,
0.024999985471367836,
-0.036005809903144836,
-0.010671762749552727,
-0.0008184519247151911,
0.037487830966711044,
0.02130708284676075,
0.03773078694939613,
-0.008983231149613857,
0.028887253254652023,
0.002834971761330962,
0.01854955218732357,
-0.010611023753881454,
0.016593771055340767,
0.04025750979781151,
-0.01268220879137516,
-0.013010196387767792,
0.03583574295043945,
0.009827496483922005,
-0.033381905406713486,
0.011740760877728462,
-0.018513109534978867,
-0.012269186787307262,
0.01916908472776413,
-0.026992209255695343,
0.01914479024708271,
-0.016775986179709435,
0.015318261459469795,
0.030320681631565094,
0.034839630126953125,
-0.033430494368076324,
0.04329443722963333,
-0.00583393732085824,
-0.00437317555770278,
-0.010835756547749043,
-0.017298338934779167,
-0.02869288995862007,
0.018719619140028954,
0.008509470149874687,
0.019533516839146614,
0.027672482654452324,
0.014176377095282078,
-0.013228855095803738,
-0.008709907531738281,
-0.012293482199311256,
-0.008801015093922615,
0.02893584407866001,
-0.03187558799982071,
0.009420548565685749,
0.03870260342955589,
0.0046738311648368835,
-0.002130404580384493,
0.014042751863598824,
0.01665451005101204,
-0.00938410498201847,
0.0027089391369372606,
-0.010349848307669163,
0.010908642783761024,
-0.04290571063756943,
0.00032950661261565983,
0.1215742751955986,
-0.022934874519705772,
-0.011376329697668552,
0.02282554656267166,
0.01782068982720375,
-0.05238092318177223,
0.026433415710926056,
-0.012008010409772396,
0.02274051122367382,
-0.02896013855934143,
0.02587462030351162,
-0.01401845645159483,
0.01903546042740345,
0.006644797045737505,
0.014723023399710655,
-0.012597174383699894,
0.018743915483355522,
0.018841097131371498,
0.010732500813901424,
-0.0011107561876997352,
-0.0157069880515337,
0.016618065536022186,
-0.01722545176744461,
0.011570692993700504,
-0.00940840132534504,
-0.02368803322315216,
-0.008825310505926609,
0.004676868207752705,
-0.020638957619667053,
-0.0007474637241102755,
0.029373161494731903,
-0.0024310604203492403,
0.009286923334002495,
-0.006456507369875908,
-0.018428074195981026,
-0.03515547141432762,
-0.013605434447526932,
-0.0037840113509446383,
0.006547615397721529,
-0.021343525499105453,
0.013192412443459034,
0.02233963832259178,
-0.007300773169845343,
0.002965559484437108,
0.035568494349718094,
0.0074586933478713036,
-0.02139211632311344,
0.006954563781619072,
0.00534802908077836,
-0.04101066663861275,
0.006571910809725523,
-0.021027684211730957,
0.0029549302998930216,
-0.007270404137670994,
-0.0270650964230299,
0.0011479585664346814,
0.012111266143620014,
0.00034924663486890495,
-0.019399892538785934,
-0.03406217694282532,
-0.022728364914655685,
0.02095479890704155,
0.021963058039546013,
0.006899898871779442,
0.014188524335622787
] | 2025-01-18 | 1 | 39824562 | [
"CAR T cells",
"CAR T cell production",
"CAR T cell therapy",
"CAR)-modified T cells",
"cancer cells",
"human CAR-modified T cells",
"the administered CAR T cells",
"high treatment costs",
"experimental immunotherapeutic treatment",
"proven clinical success",
"outstanding clinical response rates",
"stable gene integration",
"that CAR T cells",
"B and plasma cell malignancies",
"sufficient transduction efficiency",
"autologous chimeric antigen receptor",
"Optimal production",
"therapeutic success",
"cellular composition",
"viral and non-viral strategies",
"Retrovirus-based protocols",
"this promising treatment approach",
"vector design and manufacturing process",
"immunophenotype",
"terms",
"advantages",
"the manufacturing protocol",
"a retrovirus-based generation protocol",
"the CAR generation",
"GMP"
] | [
"Adoptive T cell therapy",
"CAR T cells",
"Chimeric antigen receptor",
"Immunotherapy",
"Retrovirus"
] | 0 | 10.1016/bs.mcb.2024.10.017 | [
"Stock",
"Fertig",
"Menkhoff",
"Strzalkowski",
"Caruso",
"Kobold"
] | [
"Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany; Department of Medicine III, LMU University Hospital, LMU Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, A Partnership Between the DKFZ Heidelberg and LMU University Hospital, Munich, Germany. Electronic address: [email protected].",
"Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.",
"Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.",
"Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.",
"CHU de Québec-Université Laval Research Center (Oncology division), Université Laval Cancer Research Center, Québec, QC, Canada.",
"Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, A Partnership Between the DKFZ Heidelberg and LMU University Hospital, Munich, Germany; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), Neuherberg, Germany. Electronic address: [email protected]."
] | [
"39824562"
] | [] | 8.767393 | 3.024045 |
39824530 | 17 | Glut3 overexpression improves environmental glucose uptake and antitumor efficacy of CAR-T cells in solid tumors. | Glucose deprivation inhibits T-cell metabolism and function. Glucose levels are low in the tumor microenvironment of solid tumors and insufficient glucose uptake limits the antitumor response of T cells. Furthermore, glucose restriction can contribute to the failure of chimeric antigen receptor T (CAR-T) cell therapy for solid tumors. However, the impact of glucose restriction remains unknown in CAR-T cell therapy.
Glucose transporters were detected and overexpressed in CAR-T cells. The impacts of glucose restriction on CAR-T cells were checked in vitro and in vivo.
Glucose restriction significantly decreased CAR-T cell activation, effector function, and expansion. CAR-T cells expressed high levels of the glucose transporter Glut1, which has a low affinity for glucose. Overexpression of Glut1 failed to improve CAR-T cell function under glucose-restricted conditions. In contrast, the function and antitumor potential of CAR-T cells was enhanced by the overexpression of Glut3, which has the highest affinity for glucose among the Glut transporter family and is expressed in minor parts of CAR-T cells. Glut3-overexpressing CAR-T cells demonstrated increased tumoricidal efficacy in multiple xenografts and syngenetic mouse models. Furthermore, Glut3 overexpression activated the PI3K/Akt pathway and increased OXPHOS and mitochondrial fitness.
We provide a direct and effective approach to enhance low glucose uptake levels by CAR-T cells and improve their antitumor efficacy against solid tumors. | [
-0.017342347651720047,
0.025132853537797928,
0.029197467491030693,
0.024184444919228554,
-0.016924595460295677,
-0.03845575079321861,
0.018482696264982224,
0.039200928062200546,
-0.00261800573207438,
-0.009873621165752411,
-0.024613486602902412,
-0.0014593087835237384,
-0.008789724670350552,
0.017647191882133484,
0.0018220189958810806,
-0.04360425844788551,
0.049497947096824646,
-0.020695652812719345,
0.020131122320890427,
0.04981408640742302,
0.05252382531762123,
-0.00409001624211669,
-0.03678474202752113,
0.009788941591978073,
-0.048188239336013794,
0.01726331189274788,
0.02533608488738537,
-0.0035678264684975147,
-0.0004699708370026201,
-0.045049455016851425,
0.02039080671966076,
-0.015626177191734314,
-0.02456832490861416,
-0.025697384029626846,
0.015818117186427116,
0.028474869206547737,
0.03583633527159691,
0.02316829189658165,
-0.033216916024684906,
-0.033510472625494,
0.020842429250478745,
0.0003254865587223321,
-0.00473075732588768,
0.07505984604358673,
-0.03529438376426697,
0.005487226881086826,
-0.01328902505338192,
-0.07031779736280441,
-0.04710434377193451,
0.00818003248423338,
-0.04403330385684967,
0.011776085942983627,
-0.03775573521852493,
0.015118100680410862,
-0.05293028801679611,
0.022456984966993332,
-0.02323603443801403,
-0.004798500798642635,
-0.011776085942983627,
0.015569724142551422,
-0.010274437256157398,
-0.003909366670995951,
0.05383353307843208,
0.00445413775742054,
-0.036491189152002335,
0.0039940462447702885,
-0.03807187080383301,
-0.011121231131255627,
-0.017929457128047943,
0.05690457671880722,
-0.0033137882128357887,
-0.05125927925109863,
0.006514670792967081,
-0.01913755014538765,
0.03116202913224697,
-0.02171180583536625,
0.012826110236346722,
0.012848692014813423,
0.015626177191734314,
-0.01429388765245676,
0.01885528676211834,
-0.022502146661281586,
0.029378116130828857,
-0.02470381185412407,
-0.013480965048074722,
-0.021305343136191368,
0.011990606784820557,
-0.0681951642036438,
-0.020650489255785942,
0.00445413775742054,
0.01474551111459732,
-0.006396119482815266,
-0.016506843268871307,
0.05189155414700508,
-0.012995469383895397,
0.03861381858587265,
0.008789724670350552,
-0.04556882381439209,
0.003900898853316903,
0.023552171885967255,
0.029061978682875633,
-0.013480965048074722,
-0.019171422347426414,
-0.03226850554347038,
0.05672392621636391,
0.03491050377488136,
-0.0804341658949852,
-0.018482696264982224,
0.05753684788942337,
-0.0022002537734806538,
0.10847999155521393,
-0.03202011436223984,
0.034820180386304855,
0.06227889657020569,
-0.014429374597966671,
-0.052704475820064545,
-0.05202703922986984,
0.003827510168775916,
0.037597667425870895,
0.029265210032463074,
-0.008981664665043354,
-0.0010521418880671263,
-0.00842278078198433,
-0.02079726755619049,
-0.0029355534352362156,
-0.05392386019229889,
0.08346004039049149,
-0.033284660428762436,
-0.042836498469114304,
-0.03804928809404373,
0.04069128632545471,
-0.013413221575319767,
-0.003985578194260597,
-0.015253587625920773,
-0.026329657062888145,
-0.031545910984277725,
-0.024726392701268196,
0.009986527264118195,
-0.035384710878133774,
0.012058350257575512,
-0.0043412321247160435,
-0.03396209701895714,
0.026149006560444832,
0.01648426242172718,
-0.0527496375143528,
-0.03766540810465813,
-0.0003888196952175349,
0.03423307090997696,
-0.011205910705029964,
0.07054360955953598,
-0.01509551890194416,
0.024297351017594337,
0.049994733184576035,
-0.02684902399778366,
0.0017994377994909883,
-0.02044725976884365,
0.029242629185318947,
0.08544718474149704,
-0.04376232996582985,
-0.05261415243148804,
0.006057401653379202,
-0.004953746683895588,
0.008366327732801437,
-0.00974377989768982,
-0.016518132761120796,
-0.0008700811304152012,
-0.02608126401901245,
0.02122630923986435,
-0.05365288630127907,
-0.03317175433039665,
-0.03290078043937683,
-0.03775573521852493,
-0.057717498391866684,
-0.01997305452823639,
-0.059840127825737,
-0.002547439420595765,
-0.032449156045913696,
0.04868502542376518,
0.01669878326356411,
-0.006029175128787756,
-0.005696102976799011,
0.010692189447581768,
0.007384045980870724,
-0.009794587269425392,
0.022084394469857216,
0.005755378399044275,
-0.024229606613516808,
0.04981408640742302,
-0.01004862505942583,
0.017093954607844353,
0.015908442437648773,
-0.016337484121322632,
0.05008506029844284,
-0.011330107226967812,
-0.012713205069303513,
-0.014553571119904518,
0.019532721489667892,
0.025200597941875458,
-0.020198866724967957,
0.034820180386304855,
0.0011622251477092505,
-0.009992172010242939,
-0.014711638912558556,
-0.030236201360821724,
-0.013447092846035957,
-0.031839463859796524,
-0.0037343627773225307,
0.04994957149028778,
0.001956094754859805,
0.03716862201690674,
0.03714604303240776,
0.012216418981552124,
-0.028542611747980118,
0.029761996120214462,
-0.0005984012968838215,
0.02811357006430626,
0.005504162982106209,
0.0502205453813076,
0.022310206666588783,
0.023710239678621292,
-0.02671353705227375,
-0.036626674234867096,
0.012476102448999882,
-0.012227709405124187,
-0.030078133568167686,
-0.013142246752977371,
0.013943878933787346,
0.0006058107246644795,
0.01795203797519207,
-0.019882729277014732,
0.01109300460666418,
0.009399416856467724,
0.013684195466339588,
-0.04008159413933754,
0.0005648823571391404,
-0.0382751002907753,
0.057085223495960236,
0.00413800124078989,
0.05726587399840355,
-0.042339712381362915,
-0.0020323062781244516,
0.009890557266771793,
-0.021124694496393204,
-0.01892302930355072,
-0.012645461596548557,
-0.00977765116840601,
-0.009066344238817692,
-0.11082843691110611,
-0.024952204897999763,
-0.008671173825860023,
-0.016224578022956848,
0.015479398891329765,
-0.012035769410431385,
0.00012631347635760903,
0.018177850171923637,
-0.01551327109336853,
0.05654327571392059,
-0.022106975317001343,
0.05121411755681038,
-0.04398813843727112,
0.01809881627559662,
0.01794074848294258,
-0.012701913714408875,
-0.051801227033138275,
-0.004600915592163801,
0.03188462555408478,
-0.01661974936723709,
0.013763229362666607,
-0.012758366763591766,
0.014147109352052212,
0.0495431087911129,
-0.010855902917683125,
0.05085282027721405,
-0.014113238081336021,
-0.03172655776143074,
0.00605175644159317,
0.0015538674779236317,
0.022806992754340172,
-0.023913471028208733,
0.005464645568281412,
-0.011347043327987194,
0.026600630953907967,
-0.012589008547365665,
0.022152138873934746,
0.0050101992674171925,
-0.048594702035188675,
0.01912626065313816,
0.05171090364456177,
-0.017071371898055077,
-0.00890827551484108,
0.008755852468311787,
-0.008326810784637928,
-0.011821247637271881,
-0.010257501155138016,
-0.001184100634418428,
-0.0030625725630670786,
-0.03346531093120575,
-0.002890391042456031,
-0.031771719455718994,
-0.0014705994399264455,
-0.035994403064250946,
0.041639696806669235,
-0.058891717344522476,
-0.046652719378471375,
-0.004533172119408846,
0.007942929863929749,
0.008467942476272583,
0.016122963279485703,
0.014260015450417995,
0.05134960636496544,
-0.003452097997069359,
-0.007717118598520756,
0.05794331058859825,
0.015231006778776646,
-0.01586327888071537,
0.03755250200629234,
0.03529438376426697,
-0.03737185522913933,
0.006057401653379202,
0.005035603418946266,
-0.026149006560444832,
-0.05564003065228462,
-0.05934334173798561,
0.03922351077198982,
0.03610730916261673,
-0.04723982885479927,
0.03323949873447418,
-0.010217984206974506,
0.013672905042767525,
-0.0011939798714593053,
0.026036100462079048,
-0.011172039434313774,
0.03994610905647278,
-0.010635736398398876,
0.01328902505338192,
-0.0026659907307475805,
-0.037055715918540955,
-0.006012239493429661,
0.03493308648467064,
0.03457178920507431,
0.02935553528368473,
0.03452662378549576,
-0.0013675728114321828,
0.01482454501092434,
0.0014550748746842146,
0.012069640681147575,
-0.028632936999201775,
0.032742712646722794,
0.013040632009506226,
0.017150405794382095,
0.0005916975205764174,
0.021135985851287842,
-0.0070622642524540424,
0.04062354564666748,
-0.015366493724286556,
0.037123460322618484,
-0.005797718185931444,
-0.02136179618537426,
0.029513603076338768,
0.02032306231558323,
-0.018550440669059753,
0.005554970353841782,
-0.010759932920336723,
0.027729690074920654,
0.06720159202814102,
0.028136150911450386,
-0.019803695380687714,
0.026600630953907967,
-0.03425564989447594,
-0.017568157985806465,
-0.04028482735157013,
-0.003085153875872493,
0.019792404025793076,
-0.04773661494255066,
-0.04791726544499397,
0.03434597700834274,
-0.03400725871324539,
0.03116202913224697,
0.04723982885479927,
-0.004126710817217827,
0.0502205453813076,
-0.011843829415738583,
0.01830204762518406,
-0.019860148429870605,
-0.004883180372416973,
-0.00991878379136324,
0.03775573521852493,
-0.00554650230333209,
-0.048594702035188675,
-0.0010034511797130108,
-0.0006174541776999831,
-0.00610256427899003,
0.005247301887720823,
-0.012092222459614277,
-0.039336416870355606,
0.045320428907871246,
-0.015829408541321754,
0.04586237668991089,
0.05125927925109863,
0.003195237135514617,
0.01787300407886505,
-0.021124694496393204,
-0.041007425636053085,
-0.041571952402591705,
-0.00047808594536036253,
-0.03791380301117897,
0.06724675744771957,
0.010940582491457462,
-0.014734220691025257,
0.01440679281949997,
-0.018821414560079575,
0.001772622694261372,
0.020639199763536453,
-0.005447709932923317,
0.017579449340701103,
-0.03734927251935005,
-0.014632605016231537,
0.020142413675785065,
-0.020221447572112083,
0.005614246241748333,
0.008462297730147839,
-0.0007017807802185416,
0.0032460447400808334,
-0.042271971702575684,
-0.016992338001728058,
0.028339382261037827,
0.021181147545576096,
-0.008247775956988335,
0.012961598113179207,
-0.07659536600112915,
-0.010246210731565952,
0.032945942133665085,
-0.00008494404755765572,
-0.04931730031967163,
-0.02295377105474472,
0.018064944073557854,
0.01283740159124136,
-0.001971619436517358,
-0.03877188637852669,
0.014079365879297256,
-0.04082677513360977,
-0.008902630768716335,
0.024929624050855637,
-0.05058184638619423,
0.03527180477976799,
-0.009213121607899666,
0.009980881586670876,
0.022716667503118515,
-0.000046000335714779794,
-0.018008491024374962,
0.0018714152975007892,
-0.002211544429883361,
-0.0031218482181429863,
-0.006825161632150412,
-0.04967859759926796,
0.00405332213267684,
0.039765458554029465,
-0.05482710525393486,
-0.006768709048628807,
-0.031545910984277725,
0.028000663965940475,
-0.05315610021352768,
-0.0159310232847929,
-0.0540141835808754,
0.007982447743415833,
0.05442064628005028,
0.03396209701895714,
0.02581029012799263,
0.009523613378405571,
-0.027458716183900833,
-0.0039206575602293015,
0.017714936286211014,
-0.0007515299366787076,
0.04967859759926796,
-0.0003902310272678733,
0.03520406037569046,
0.008473588153719902,
0.02818131260573864,
0.03116202913224697,
-0.0068816146813333035,
0.004262197762727737,
0.0007536468910984695,
-0.03229108825325966,
-0.02567480318248272,
0.040871936827898026,
0.02881358563899994,
0.029332954436540604,
-0.0072146872989833355,
-0.027368390932679176,
0.024748973548412323,
-0.019306909292936325,
-0.028203895315527916,
0.0013146480778232217,
-0.00950103159993887,
-0.02380056492984295,
0.012476102448999882,
0.006350956857204437,
0.017026210203766823,
-0.019295619800686836,
-0.0034690338652580976,
0.0006777882226742804,
0.025561897084116936,
-0.0165632963180542,
-0.014689058065414429,
0.03202011436223984,
0.02644256316125393,
0.01450840849429369,
0.03838800638914108,
0.021689223125576973,
0.01857302151620388,
-0.027029672637581825,
-0.034955669194459915,
0.028497450053691864,
0.030371688306331635,
-0.03357821702957153,
0.018245594576001167,
-0.014858417212963104,
-0.00818003248423338,
-0.0009963945485651493,
-0.004962214268743992,
-0.012498683296144009,
-0.030665243044495583,
-0.012148675508797169,
0.015705211088061333,
0.01474551111459732,
-0.03874930739402771,
-0.022660214453935623,
-0.020503712818026543,
-0.013706776313483715,
-0.016822978854179382,
0.011708342470228672,
-0.037462178617715836,
0.04035256803035736,
0.0061985342763364315,
-0.0030230556149035692,
-0.0382751002907753,
-0.018460115417838097,
0.015321331098675728,
-0.020560165867209435,
-0.048097915947437286,
0.0073219477199018,
-0.02657805010676384,
0.02058274671435356,
0.019848857074975967,
0.0003609460545703769,
0.005391256883740425,
0.002553084632381797,
-0.04159453511238098,
-0.008434071205556393,
-0.020774686709046364,
0.022784411907196045,
-0.024387674406170845,
0.04593012109398842,
-0.02811357006430626,
0.005772314500063658,
-0.010421214625239372,
-0.007762280758470297,
-0.014045494608581066,
-0.006288858596235514,
0.0032403995282948017,
-0.021655352786183357,
0.0004488009726628661,
-0.015118100680410862,
-0.0286555178463459,
-0.042610686272382736,
-0.005859816446900368,
-0.001364044495858252,
-0.010630090720951557,
-0.04529784992337227,
0.013108375482261181,
-0.003618634305894375,
0.03938157856464386,
0.0007656431407667696,
0.01642780937254429,
0.04044289514422417,
0.015400364995002747,
-0.023755401372909546,
0.012611589394509792,
0.03348788991570473,
0.009433288127183914,
-0.012769658118486404,
0.007988092489540577,
0.006175952963531017,
0.020898882299661636,
-0.016789108514785767,
0.026532886549830437,
-0.015242297202348709,
-0.013413221575319767,
-0.007271140348166227,
-0.01155027374625206,
0.044981710612773895,
0.015163262374699116,
0.018968190997838974,
0.014248725026845932,
-0.03755250200629234,
0.035791169852018356,
0.0007938696071505547,
-0.005809008609503508,
-0.0470140166580677,
0.023958632722496986,
0.0002757373731583357,
-0.0131874093785882,
-0.0060912733897566795,
-0.03152332827448845,
-0.0018954077968373895,
0.042542945593595505,
0.010703479871153831,
-0.024523161351680756,
-0.021384378895163536,
0.003449275391176343,
0.030710406601428986,
0.03195236995816231,
-0.04450750723481178,
-0.017624611034989357,
0.0019518608460202813,
-0.012622879818081856,
-0.031003961339592934,
-0.009715553373098373,
0.03041685000061989,
0.005292464047670364,
-0.005464645568281412,
-0.0010352060198783875,
-0.024455418810248375,
-0.009698617272078991,
-0.003900898853316903,
-0.03299110382795334,
-0.024432837963104248,
0.01022927463054657,
0.01429388765245676,
0.008439715951681137,
-0.016247158870100975,
-0.01927303709089756,
0.004905761685222387,
0.024094119668006897,
0.010127659887075424,
-0.0292877908796072,
-0.0045021227560937405,
-0.017985910177230835,
-0.003838800825178623,
-0.019668208435177803,
-0.00010787806240841746,
-0.024681231006979942,
0.021124694496393204,
-0.03935899958014488,
0.01095751766115427,
0.014180981554090977,
-0.03576859086751938,
-0.012453521601855755,
0.003844446036964655,
-0.008716335520148277,
0.02942327782511711,
-0.0350685752928257,
0.010511539876461029,
-0.011674470268189907,
-0.011798666790127754,
0.018764961510896683,
-0.009275220334529877,
-0.02427476830780506,
0.07216945290565491,
0.04249778017401695,
-0.04315263777971268,
0.010426860302686691,
-0.01506164763122797,
0.0026518774684518576,
-0.033081430941820145,
-0.010726060718297958,
0.0038613819051533937,
0.007130007725208998,
0.033352404832839966,
0.004753338638693094,
0.053472235798835754,
0.006413055118173361,
0.020210156217217445,
-0.04121065512299538,
0.010816385969519615,
0.01054541114717722,
0.019363362342119217,
-0.04958827421069145,
-0.04218164458870888,
-0.006661448162049055,
-0.016224578022956848,
-0.008473588153719902,
-0.012679332867264748,
-0.033984676003456116,
0.004671481903642416,
0.003319433657452464,
-0.016190705820918083,
-0.0018064944306388497,
0.008044545538723469,
-0.0028805118054151535,
-0.0019081097561866045,
0.0031472521368414164,
-0.0016794753028079867,
-0.016574585810303688,
0.00007184519927250221,
0.004431556910276413,
0.02998780831694603,
0.01921658404171467,
-0.0009681681403890252,
-0.032516900449991226,
0.015874570235610008,
0.03547503426671028,
-0.009935719892382622,
-0.035316966474056244,
0.026758698746562004,
0.0029355534352362156,
0.03470727428793907,
-0.02567480318248272,
-0.0035113736521452665,
-0.01780526153743267,
0.024523161351680756,
-0.0025135676842182875,
0.01096316333860159,
-0.01864076405763626,
0.007892122492194176,
0.004324296023696661,
0.007553405128419399,
0.024297351017594337,
0.04182034730911255,
0.04723982885479927,
-0.002986361039802432,
0.0024881637655198574,
-0.0018897625850513577,
-0.01183253899216652,
0.023281197994947433,
0.01419227197766304,
-0.016574585810303688,
0.03622021526098251,
-0.017082663252949715,
0.03707829862833023,
0.04346877336502075,
0.0002688571694307029,
-0.05315610021352768,
-0.029829740524291992,
-0.015671338886022568,
0.001902464427985251,
-0.03278787434101105,
-0.027029672637581825,
0.016179416328668594,
-0.0008009262382984161,
0.008721981197595596,
-0.027232903987169266,
-0.022784411907196045,
0.016393937170505524,
0.007700182497501373,
0.014632605016231537,
0.023044094443321228,
-0.0011855119373649359,
0.005772314500063658,
-0.05505291745066643,
-0.013334186747670174,
0.006226760800927877,
0.012374486774206161,
0.0357460081577301,
0.0050892336294054985,
-0.01005427073687315,
-0.0043863942846655846,
0.01429388765245676,
-0.021892454475164413,
-0.004135178867727518,
-0.056814249604940414,
0.0026405868120491505,
0.007937285117805004,
-0.004499300383031368,
0.01432775892317295,
0.006938067730516195,
-0.019521430134773254,
-0.01429388765245676,
0.02678127959370613,
0.015840698033571243,
0.014497118070721626,
-0.04448492452502251,
0.014700348488986492,
-0.008925211615860462,
-0.019577883183956146,
0.02714257873594761,
-0.03421048820018768,
0.008151805959641933,
0.0015002371510490775,
-0.008817951194941998,
-0.03319433704018593,
0.004533172119408846,
-0.005718683823943138,
0.009591356851160526,
-0.0007550582522526383,
-0.022840864956378937,
0.006678384263068438,
0.03459436818957329,
0.005704570561647415,
-0.001309708459302783,
-0.017060082405805588,
0.027729690074920654,
-0.041707441210746765,
0.041368722915649414,
-0.0188439954072237,
0.02240053191781044,
0.05351739749312401,
-0.0790792927145958,
-0.02295377105474472,
0.0061194999143481255,
-0.003819042118266225,
0.008637301623821259,
0.01165188942104578,
-0.012250290252268314,
0.003463388653472066,
0.0521625280380249,
-0.008388908579945564,
-0.007457435131072998,
-0.008744562044739723,
0.013921298086643219,
-0.01997305452823639,
0.023145711049437523,
-0.002239770954474807,
0.01352612767368555,
-0.04502687603235245,
-0.011313171125948429,
0.026284493505954742,
-0.03832026198506355,
-0.00455575343221426,
0.021260181441903114,
0.03459436818957329,
0.024026377126574516,
0.02456832490861416,
-0.025765126571059227,
-0.01578424498438835,
-0.04746564105153084,
-0.008496169000864029,
0.003282739082351327,
-0.01648426242172718,
-0.020481130108237267,
0.05125927925109863,
-0.02664579264819622,
-0.041639696806669235,
0.03305884823203087,
0.0036666193045675755,
-0.0058372351340949535,
0.009828458540141582,
0.017285894602537155,
-0.01634877547621727,
0.028542611747980118,
0.012780948542058468,
-0.02804582566022873,
-0.009805877692997456,
-0.03931383416056633,
-0.04039773344993591,
-0.016021348536014557,
-0.02373282052576542,
0.029739415273070335,
-0.00010726061009336263,
-0.028497450053691864,
0.00803889986127615,
-0.006514670792967081,
0.005004554055631161,
0.01711653545498848,
0.028226476162672043,
0.0008813717286102474,
0.019532721489667892,
-0.04493654891848564,
0.035994403064250946,
0.02206181362271309,
-0.0131874093785882,
-0.005261415150016546,
-0.010280082933604717,
-0.004558575805276632,
0.021677933633327484,
-0.01725202240049839,
0.02142954058945179,
-0.0030992671381682158,
0.012622879818081856,
-0.022344078868627548,
0.06250470876693726,
-0.006322730798274279,
0.0022863445337861776,
0.0061928885988891125,
0.01091800071299076,
-0.02797808311879635,
0.004010982345789671,
0.0022708200849592686,
0.009066344238817692,
0.009032472036778927,
0.019882729277014732,
0.007039682939648628,
0.02267150580883026,
0.002716798335313797,
0.006249341648072004,
0.014801964163780212,
-0.020774686709046364,
0.016179416328668594,
-0.0038952536415308714,
-0.03202011436223984,
0.015016485005617142,
-0.021327925845980644,
-0.013966459780931473,
0.004112597554922104,
-0.00005680578397004865,
-0.0014804786769673228,
-0.01178737636655569,
0.035926658660173416,
-0.025990938767790794,
0.0029750706162303686,
-0.006441281642764807,
-0.028497450053691864,
-0.005955786444246769,
0.06101435050368309,
0.021734386682510376,
0.007101781200617552,
-0.05017538368701935,
0.02115856669843197,
-0.020910173654556274,
0.028000663965940475,
0.006904195994138718,
-0.012939016334712505,
-0.0009364133584313095,
0.007039682939648628,
-0.00863165594637394,
-0.009472805075347424,
-0.04258810728788376,
0.07871799916028976,
0.03235883265733719,
0.014914870262145996,
0.03159107267856598,
-0.011307526379823685,
0.0017077018273994327,
-0.004250907339155674,
-0.007982447743415833,
-0.0029637799598276615,
0.032878197729587555,
0.007880832068622112,
-0.004084371030330658,
0.01731976494193077,
0.013040632009506226,
-0.007175170350819826,
0.036152470856904984,
0.017376217991113663,
0.0441010445356369,
0.010737351141870022,
0.020232737064361572,
0.0036609738599509,
-0.013706776313483715,
0.006362247746437788,
-0.0180197823792696,
-0.002423242898657918,
-0.017850423231720924,
-0.03694280982017517,
0.011397850699722767,
0.00714694382622838,
-0.02748129703104496,
0.005351739935576916,
0.00709613598883152,
0.06060788780450821,
0.04882051423192024,
-0.011697052046656609,
-0.01265675202012062,
0.006288858596235514,
-0.016585877165198326,
-0.010150240734219551,
0.017839131876826286,
-0.019374653697013855,
0.05279479920864105,
-0.02782001532614231,
0.002804300282150507,
0.015558433718979359,
-0.0022595294285565615,
-0.021316634491086006,
0.03622021526098251,
0.033420149236917496,
0.02018757537007332,
-0.0018629473634064198,
-0.06471766531467438,
0.04737531766295433,
0.03346531093120575,
0.02373282052576542,
0.01921658404171467,
-0.01409065630286932,
0.009275220334529877,
0.014553571119904518,
0.019464977085590363,
0.011708342470228672,
-0.0015016485704109073,
0.04057838022708893,
0.015501980669796467,
0.04931730031967163,
-0.04502687603235245,
0.002800066489726305,
-0.01982627622783184,
0.002901681698858738,
0.006734837312251329,
-0.04696885496377945,
0.0039658197201788425,
0.012690623290836811,
0.017714936286211014,
0.026419980451464653,
-0.010675253346562386,
-0.011369624175131321,
0.004338409285992384,
-0.03938157856464386,
-0.01196802593767643,
-0.010065561160445213,
0.016168124973773956,
0.016811689361929893,
-0.03644602745771408,
0.0028226475697010756,
0.03678474202752113,
0.012250290252268314,
-0.028994236141443253,
-0.006085628177970648,
0.06769838184118271,
0.0010182701516896486,
0.041368722915649414,
-0.04014933854341507,
0.021113403141498566,
0.022219881415367126,
0.03547503426671028,
-0.006542897317558527,
0.005021490156650543,
-0.023213453590869904,
-0.011155103333294392,
-0.035587940365076065,
-0.025900613516569138,
-0.009303446859121323,
-0.024319931864738464,
0.00796551164239645,
0.002376669319346547,
0.025155434384942055,
0.002221423666924238,
0.031749140471220016,
0.03931383416056633,
-0.016258450224995613,
0.031184609979391098,
-0.0018798833480104804,
0.027390971779823303,
0.001153757213614881,
0.04292682558298111,
-0.007942929863929749,
-0.036762163043022156,
0.027029672637581825,
0.022321496158838272,
0.033713702112436295,
0.019239166751503944,
0.009619583375751972,
-0.055775515735149384,
-0.016879431903362274,
-0.016574585810303688,
0.05044635757803917,
-0.018381081521511078,
0.0037541212514042854,
-0.01684556156396866,
0.01263417024165392,
0.02058274671435356,
0.002506511053070426,
0.023529591038823128,
0.03109428659081459,
0.011426077224314213,
0.0033730638679116964,
-0.013130956329405308,
0.00845665205270052,
-0.02524575963616371,
-0.005842880345880985,
0.035249222069978714,
-0.03393951430916786,
-0.018279464915394783,
0.019035935401916504,
0.009896202012896538,
0.00026479962980374694,
-0.0024105410557240248,
-0.019916601479053497,
0.04299456626176834,
0.04152679070830345,
0.02157631888985634,
-0.006836452521383762,
-0.003127493429929018,
0.008981664665043354,
-0.02872326225042343,
0.03576859086751938,
-0.00247969594784081,
0.0014261426404118538,
-0.026668373495340347,
-0.03159107267856598,
-0.0029694251716136932,
-0.00872762594372034,
0.015343911945819855,
0.005035603418946266,
0.026894185692071915,
-0.013221281580626965,
0.0037428305950015783,
0.014564861543476582,
-0.005529566667973995,
-0.026329657062888145,
0.021542446687817574,
0.0011579911224544048,
-0.01437292154878378,
-0.019476268440485,
-0.008163096383213997,
0.014214852824807167,
-0.034955669194459915,
0.021621480584144592,
-0.01342451199889183,
0.008964728564023972,
0.029197467491030693,
-0.014993904158473015,
-0.03032652474939823,
0.014124528504908085,
-0.011888992041349411,
-0.025494152680039406,
-0.024748973548412323,
0.04373974725604057,
-0.002533326158300042,
-0.021181147545576096,
0.014847125858068466,
-0.00034736207453534007,
-0.02791033871471882,
0.008654237724840641,
0.03445888310670853,
-0.007180815562605858,
0.03138783946633339,
-0.035384710878133774,
0.03646860644221306,
0.0017486301949247718,
0.013300315476953983,
0.02025531977415085,
-0.04297198727726936,
-0.02343926578760147,
0.008055835962295532,
-0.008428425528109074,
0.002224246272817254,
-0.007807443384081125,
-0.01537778414785862,
0.049362462013959885,
0.017985910177230835,
0.002826881594955921,
-0.016732655465602875,
-0.02199406921863556,
-0.00023357408645097166,
0.004660191014409065,
-0.0009667567792348564,
-0.007225977722555399,
-0.0013689841143786907,
-0.03443630039691925,
0.019939182326197624,
0.004019449930638075,
-0.014711638912558556,
-0.0009215944446623325,
0.02114727534353733,
-0.03296852484345436,
0.0003360714763402939,
-0.008219549432396889,
-0.0011184740578755736,
0.04737531766295433,
-0.02275053970515728,
-0.022163428366184235,
0.05473678186535835,
0.005552147980779409,
0.002308925613760948,
0.004332764074206352,
0.03777831420302391,
0.01606651023030281,
0.019047226756811142,
-0.02212955616414547,
0.041978415101766586,
0.00422832602635026,
-0.027571622282266617,
0.003717426909133792,
0.00025633169570937753,
-0.03125235438346863,
-0.010985744185745716,
0.008501814678311348,
-0.007530823815613985,
-0.004925520159304142,
0.0228295736014843,
-0.0036101662553846836,
0.016924595460295677,
-0.016235869377851486,
-0.01008814200758934,
0.046291422098875046,
-0.0008940736297518015,
0.005278350785374641,
0.03972029685974121,
-0.015739083290100098,
-0.008676818571984768,
0.003437984734773636,
-0.00273091159760952,
-0.041571952402591705,
-0.01842624321579933,
-0.027639364823698997,
-0.007406627293676138,
-0.014101947657763958,
0.004338409285992384,
0.0015665694372728467,
-0.01461002416908741,
0.02323603443801403,
-0.014937451109290123,
-0.03780089691281319,
-0.03685248643159866,
0.03687506914138794,
-0.005888042971491814,
-0.005662231240421534,
-0.008462297730147839,
-0.03222334384918213,
-0.017026210203766823,
0.007937285117805004,
-0.01893432065844536,
0.019532721489667892,
0.013864845037460327,
0.0021494461689144373,
0.006356602534651756,
-0.013198699802160263,
-0.022073104977607727,
0.002832526806741953,
-0.010409924201667309,
-0.0655757486820221,
-0.003931947983801365,
-0.032449156045913696,
-0.03775573521852493,
-0.026487724855542183,
-0.012826110236346722,
-0.011572855524718761,
-0.03549761697649956,
0.011888992041349411,
0.006695319898426533,
-0.015535851940512657,
0.03493308648467064,
-0.018674636259675026,
0.00855262205004692,
0.006294504273682833,
0.01332289632409811,
-0.002269408665597439,
0.0013259387342259288,
0.033284660428762436,
-0.001508705085143447,
0.020548874512314796,
-0.04710434377193451,
-0.041639696806669235,
-0.0009385303128510714,
-0.008891340345144272,
0.023281197994947433,
-0.001213032752275467,
0.027729690074920654,
0.003968642558902502,
-0.012035769410431385,
0.03229108825325966,
0.017421381548047066,
0.019171422347426414,
-0.028903910890221596,
-0.007767925970256329,
-0.024297351017594337,
0.006424346007406712,
0.013830972835421562,
0.0070340377278625965,
0.04039773344993591,
-0.01712782494723797,
-0.010421214625239372,
-0.03414274379611015,
0.019860148429870605,
-0.03773315250873566,
-0.0008799603674560785,
-0.021237600594758987,
0.009094570763409138,
-0.03987836465239525,
-0.006497734691947699,
-0.03696539252996445,
0.02567480318248272,
0.024861879646778107,
0.027661945670843124,
-0.017093954607844353,
0.016100382432341576,
0.0019419814925640821,
-0.031342677772045135,
0.014429374597966671,
0.02456832490861416,
0.022705378010869026,
-0.0005295992596074939,
0.024116700515151024,
-0.031749140471220016,
0.04590754210948944,
0.0005680578178726137,
0.009969591163098812,
-0.0165632963180542,
-0.04369458556175232,
0.0070622642524540424,
0.0047279344871640205,
-0.018200431019067764,
-0.010223629884421825,
0.025990938767790794,
-0.02171180583536625,
-0.018460115417838097,
0.036626674234867096,
-0.01829075627028942,
-0.003195237135514617,
0.010122014209628105,
-0.03459436818957329,
-0.012272872030735016,
-0.013616451993584633,
0.005540857091546059,
0.005741265136748552,
-0.022998932749032974,
-0.015151971951127052,
-0.006638867314904928,
-0.01287127286195755,
0.0009731077589094639,
-0.001858713454566896,
-0.013751938939094543,
-0.01033089030534029,
0.000872903736308217,
-0.019081097096204758,
-0.023394104093313217,
0.003068218007683754,
-0.007666310761123896,
-0.022163428366184235,
0.010443796403706074,
0.011798666790127754,
0.005580374039709568,
0.04301714897155762,
-0.015151971951127052,
-0.015422946773469448,
0.047059182077646255,
0.00247969594784081,
0.0152761684730649,
-0.00041316504939459264,
0.01374064851552248,
0.02581029012799263,
-0.01120026595890522,
-0.007480015978217125,
-0.017060082405805588,
0.010929291136562824,
0.02684902399778366,
-0.016800398007035255,
0.014542280696332455,
0.04918181151151657,
0.002873455174267292,
0.02129405364394188,
-0.02490704320371151,
0.011538983322679996,
0.07379529625177383,
-0.0382751002907753,
-0.0024881637655198574,
0.0037343627773225307,
-0.0071130720898509026,
-0.04432685673236847,
0.0036440379917621613,
0.05252382531762123,
-0.006932422518730164,
0.010376052930951118,
0.010765577666461468,
0.035181477665901184,
-0.018064944073557854,
-0.017760097980499268,
0.03362337872385979,
0.029445858672261238,
-0.01047202292829752,
0.030213620513677597,
-0.001140349661000073,
-0.028542611747980118,
-0.004764629062265158,
0.020063379779458046,
0.002098638564348221,
0.00211416301317513,
0.002826881594955921,
0.007485661190003157,
0.01926174759864807,
-0.004185986239463091,
-0.011606726795434952,
0.006204179488122463,
0.002351265400648117,
-0.001981498673558235,
0.0043863942846655846,
0.005622713826596737,
-0.022513438016176224,
-0.0021071063820272684,
-0.04638174548745155,
-0.006006594281643629,
0.00922441203147173,
-0.0023851371370255947,
0.031545910984277725,
0.004281956236809492,
-0.007615503389388323,
0.027932919561862946,
-0.022174719721078873,
-0.015705211088061333,
0.04062354564666748,
-0.01328902505338192,
-0.016529424116015434,
-0.011087359860539436,
-0.015343911945819855,
-0.028474869206547737,
0.008394554257392883,
0.00329685234464705,
-0.02233278751373291,
-0.05351739749312401,
0.0020619439892470837,
0.033013686537742615,
0.006079982966184616,
-0.018392371013760567,
-0.0000194167278095847,
0.011279299855232239,
-0.012848692014813423,
-0.009393771179020405,
0.0022186010610312223,
-0.008507459424436092,
-0.04355909675359726,
-0.0034718564711511135,
-0.02581029012799263,
-0.002318805083632469,
-0.022027941420674324,
-0.014914870262145996,
-0.01578424498438835,
0.011934153735637665,
-0.012182546779513359,
-0.04527526721358299,
0.001718992367386818,
-0.0032770938705652952,
0.004705353640019894,
-0.009647809900343418,
0.030303943902254105,
-0.03159107267856598,
0.009472805075347424,
-0.011956735514104366,
0.020018216222524643,
0.02413928136229515,
0.03332982212305069,
-0.04209132120013237,
0.004039208870381117,
0.014463245868682861,
0.03082331083714962,
-0.01095751766115427,
0.04863986372947693,
0.031274933367967606,
0.004056144505739212,
-0.015208425000309944,
-0.009134087711572647,
0.014779382385313511,
-0.026194170117378235,
-0.03804928809404373,
-0.013695485889911652,
-0.03360079601407051,
0.02101178839802742,
-0.050265707075595856,
-0.018279464915394783,
0.02359733358025551,
0.01641651801764965,
0.0034295169170945883,
0.0006859033601358533,
-0.030574917793273926,
0.0008933679782785475,
0.002440178766846657,
-0.005391256883740425,
0.03082331083714962,
-0.018392371013760567,
-0.029807157814502716,
0.00672919163480401,
0.040600962936878204,
0.004615028854459524,
-0.008451007306575775,
0.00627756817266345,
-0.010771223343908787,
-0.01113816723227501,
-0.0009110094979405403,
0.0033984677866101265,
-0.0038246875628829002,
-0.012780948542058468,
-0.00796551164239645,
0.03414274379611015,
-0.008061481639742851,
0.0001974089100258425,
0.037891220301389694,
0.029603928327560425,
-0.013119665905833244,
0.007417917717248201,
-0.003181123873218894,
-0.010127659887075424,
-0.007835669443011284,
-0.033013686537742615,
0.11128006130456924,
-0.01774880848824978,
0.009845394641160965,
0.006429991219192743,
0.009122797288000584,
-0.016156835481524467,
0.021937616169452667,
-0.012927725911140442,
-0.0019913779105991125,
-0.0056763445027172565,
-0.0005881692050024867,
-0.0013866255758330226,
0.04082677513360977,
0.008044545538723469,
-0.007101781200617552,
-0.020402096211910248,
-0.012126093730330467,
0.03240399435162544,
0.007982447743415833,
-0.011211556382477283,
0.009766360744833946,
-0.0058372351340949535,
-0.03470727428793907,
0.030439430847764015,
-0.0283168014138937,
0.005667876452207565,
-0.011064778082072735,
-0.012080932036042213,
0.017489124089479446,
-0.0038952536415308714,
0.009867975488305092,
0.018832704052329063,
0.04152679070830345,
-0.025358665734529495,
0.02330377884209156,
-0.051936715841293335,
-0.005419483408331871,
-0.034752435982227325,
-0.015874570235610008,
0.0031049123499542475,
0.026216750964522362,
-0.0011530515039339662,
0.013018050231039524,
-0.015027775429189205,
0.026284493505954742,
0.010810740292072296,
-0.022106975317001343,
-0.001745807472616434,
-0.001379569061100483,
-0.04222680628299713,
-0.0046404325403273106,
-0.000023860193323343992,
0.019498849287629128,
-0.029039397835731506,
-0.017579449340701103,
-0.0263748187571764,
-0.01178737636655569,
-0.01360516157001257,
-0.0027958324644714594,
-0.03911060467362404,
-0.00166112813167274,
0.012984178960323334,
0.040736451745033264,
0.01725202240049839,
0.016168124973773956
] | 2025-01-18 | 47 | 39824530 | [
"T cells",
"cell therapy",
"glucose restriction",
"low glucose uptake levels",
"insufficient glucose",
"glucose",
"Glucose deprivation",
"CAR-T cell function",
"CAR-T cell therapy",
"CAR-T cell activation",
"CAR-T cells",
"T-cell metabolism",
"T",
"Glucose restriction",
"Glucose transporters",
"solid tumors",
"high levels",
"effector function",
"Glut3-overexpressing CAR-T cells",
"Glucose levels",
"tumoricidal efficacy",
"Glut3 overexpression",
"function",
"multiple xenografts",
"syngenetic mouse models",
"antitumor potential",
"chimeric antigen receptor",
"Overexpression",
"the glucose transporter",
"CAR-T"
] | [
"Chimeric antigen receptor - CAR",
"Mitochondria",
"Nutrition",
"Solid tumor"
] | 0 | 10.1136/jitc-2024-010540
10.1056/NEJMra1706169
10.1038/s41573-021-00189-2
10.1126/sciimmunol.abq3016
10.3389/fimmu.2015.00001
10.1016/j.cmet.2017.06.016
10.1016/j.it.2012.01.010
10.1126/science.abb2683
10.1016/j.cell.2015.08.012
10.1182/blood-2007-06-096297
10.1016/j.cell.2015.08.016
10.1038/s41586-021-03442-1
10.1016/j.immuni.2016.01.021
10.1038/s41587-019-0398-2
10.1186/s13045-019-0831-5
10.1038/s41586-023-05778-2
10.4049/jimmunol.1700236
10.1038/s43018-021-00244-2
10.1111/j.1365-2362.2007.01786.x
10.1016/j.cmet.2014.05.004
10.2174/138920207780368187
10.1172/jci.insight.93411
10.1158/2326-6066.CIR-19-0403
10.1016/j.cmet.2022.01.007
10.1038/ncomms7692
10.1172/jci.insight.138729
10.1016/j.trecan.2021.10.007
10.1016/j.molcel.2015.12.002
10.1038/s41418-017-0020-4
10.1016/j.immuni.2020.07.011
10.1158/2326-6066.CIR-21-0110
10.1172/JCI76012
10.1158/2326-6066.CIR-19-0115
10.1038/ni.2687
10.1002/eji.200838289
10.1038/s41467-024-52666-y
10.1126/sciimmunol.aap9520
10.1152/ajpendo.90388.2008
10.3389/fimmu.2022.976628
10.1126/scitranslmed.adk7399
10.1016/j.cell.2020.07.018
10.1038/mt.2009.210
10.1038/nri.2017.66
10.1158/0008-5472.CAN-21-4052
10.1126/science.aaf6284
10.1038/s41423-020-0365-3
10.1136/jitc-2022-006522
10.1016/j.immuni.2016.07.009
10.1016/j.isci.2023.108666
10.1038/cddis.2017.122 | [
"Hu",
"Li",
"Liang",
"Liu",
"Wang",
"Shen",
"Zhao",
"Wang",
"Zhang"
] | [
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.",
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China [email protected] [email protected].\nZhongyuan Cell Therapy and Immunotherapy Laboratory, Henan Academy of Innovations in Medical Science, Zhengzhou, People's Republic of China.",
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.",
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.",
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.",
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.",
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.\nZhongyuan Cell Therapy and Immunotherapy Laboratory, Henan Academy of Innovations in Medical Science, Zhengzhou, People's Republic of China.",
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.",
"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China [email protected] [email protected].\nZhongyuan Cell Therapy and Immunotherapy Laboratory, Henan Academy of Innovations in Medical Science, Zhengzhou, People's Republic of China.\nSchool of Public Health, Zhengzhou University, Zhengzhou, People's Republic of China."
] | [
"39824530",
"29972754",
"33972771",
"37058548",
"25657648",
"28683298",
"22342741",
"33479154",
"26321681",
"18042802",
"26321679",
"26885860",
"32015548",
"31783892",
"29288199",
"34746799",
"17373964",
"24930970",
"18660845",
"28614802",
"32019781",
"35123658",
"25809635",
"32814710",
"34810156",
"26725009",
"29229998",
"32758419",
"34344697",
"25437876",
"31575551",
"23955661",
"18792400",
"39370422",
"30683669",
"18577699",
"36203587",
"39196962",
"32730808",
"19773745",
"28669986",
"35648389",
"27708054",
"32055005",
"36914208",
"27496732",
"28333151"
] | [] | 10.191236 | 4.997798 |
39820712 | 18 | PRDM1 is a key regulator of the natural killer T-cell central memory program and effector function. | Natural killer T cells (NKTs) are a promising platform for cancer immunotherapy, but few genes involved in regulation of NKT therapeutic activity have been identified. To find regulators of NKT functional fitness, we developed a CRISPR/Cas9-based mutagenesis screen that employs a guide RNA (gRNA) library targeting 1,118 immune-related genes. Unmodified NKTs and NKTs expressing a GD2-specific chimeric antigen receptor (GD2.CAR) were transduced with the gRNA library and exposed to CD1d+ leukemia or CD1d-GD2+ neuroblastoma cells, respectively, over six challenge cycles in vitro. Quantification of gRNA abundance revealed enrichment of PRDM1-specific gRNAs in both NKTs and GD2.CAR NKTs, a result that was validated through targeted PRDM1 knockout. Transcriptional, phenotypic, and functional analyses demonstrated that CAR NKTs with PRDM1 knockout underwent central memory-like differentiation and resisted exhaustion. However, these cells downregulated the cytotoxic mediator granzyme B and showed reduced in vitro cytotoxicity and only moderate in vivo antitumor activity in a xenogeneic neuroblastoma model. In contrast, shRNA-mediated PRDM1 knockdown preserved effector function while promoting central memory differentiation, resulting in GD2.CAR NKTs with potent in vivo antitumor activity. Thus, we have identified PRDM1 as a regulator of NKT memory differentiation and effector function that can be exploited to improve the efficacy of NKT-based cancer immunotherapies. | [
-0.0194774828851223,
0.04680023342370987,
0.041002631187438965,
0.03552574664354324,
-0.018120596185326576,
-0.0024855686351656914,
0.006913951598107815,
0.04129868000745773,
-0.020279278978705406,
0.006722753867506981,
0.006852274760603905,
0.003151676384732127,
-0.014568022452294827,
0.019169099628925323,
0.034193530678749084,
-0.05846945568919182,
0.02893867902457714,
-0.022067902609705925,
0.009979280643165112,
0.06587065011262894,
0.05190706253051758,
0.02367149479687214,
-0.01693640649318695,
0.01486407034099102,
-0.0030730385333299637,
0.03330538794398308,
0.028741315007209778,
0.002436227397993207,
0.00886293314397335,
-0.0002499831316526979,
0.030591614544391632,
-0.011804909445345402,
-0.022894369438290596,
-0.003543322905898094,
-0.01723245345056057,
-0.00143244001083076,
0.034686941653490067,
0.0185153279453516,
-0.04028718173503876,
0.00852987915277481,
0.03463760018348694,
-0.03204718232154846,
-0.024312932044267654,
0.07223568111658096,
-0.025682153180241585,
-0.034810297191143036,
-0.006420538295060396,
-0.008733412250876427,
0.006685747765004635,
-0.01590023748576641,
-0.03372478857636452,
0.026175566017627716,
-0.013778561726212502,
0.05945628136396408,
-0.06024574115872383,
0.05427544564008713,
-0.030591614544391632,
-0.031701792031526566,
-0.014580357819795609,
0.02740909904241562,
0.015998920425772667,
-0.020735686644911766,
0.04206347092986107,
-0.023326106369495392,
-0.028716644272208214,
-0.0561504140496254,
-0.0233384408056736,
0.005603322759270668,
0.01002862211316824,
0.009689399972558022,
0.014308980666100979,
-0.01593724451959133,
0.000664951279759407,
-0.038140833377838135,
0.038264188915491104,
0.017824549227952957,
0.031208381056785583,
0.02209257334470749,
0.026792332530021667,
-0.022191256284713745,
0.04339568316936493,
-0.00936251413077116,
0.0009135852451436222,
-0.04097795858979225,
-0.010793412104249,
-0.0589628703892231,
0.040632572025060654,
-0.06804166734218597,
-0.03064095601439476,
0.003620418719947338,
0.004773771855980158,
-0.02042730338871479,
-0.038880955427885056,
0.08220262825489044,
-0.027384428307414055,
0.0014339819317683578,
0.002769281156361103,
-0.042285505682229996,
0.026965027675032616,
0.03152909874916077,
0.027853170409798622,
0.007061975542455912,
-0.005569400731474161,
-0.0302708949893713,
0.020859040319919586,
0.008640897460281849,
-0.06152861565351486,
0.020945386961102486,
0.014012932777404785,
0.015246465802192688,
0.07662706077098846,
0.008721076883375645,
-0.010830418206751347,
0.05328861624002457,
-0.02242562733590603,
-0.05787735804915428,
-0.06152861565351486,
0.013803232461214066,
0.016874728724360466,
0.025854848325252533,
-0.04778706282377243,
0.024362273514270782,
0.010787244886159897,
-0.03466227278113365,
-0.032861314713954926,
-0.004659670405089855,
0.03226921707391739,
-0.003984311129897833,
-0.018034249544143677,
-0.01789856143295765,
0.060640472918748856,
-0.015172453597187996,
0.04354370757937431,
0.014111615717411041,
-0.06631472706794739,
-0.012705388478934765,
0.01154586672782898,
0.004597993567585945,
-0.0253614354878664,
0.020242273807525635,
0.0051407478749752045,
-0.018379639834165573,
-0.011237484402954578,
0.01702275313436985,
-0.06848574429750443,
-0.038757599890232086,
-0.018256286159157753,
0.041422031819820404,
-0.017886225134134293,
0.03530370816588402,
-0.008992454037070274,
0.05020478740334511,
0.05654514580965042,
-0.03337939828634262,
-0.018589340150356293,
-0.03330538794398308,
-0.0038332033436745405,
0.06897915154695511,
-0.021808860823512077,
-0.04213748127222061,
-0.011656885035336018,
0.0356244295835495,
0.011299160309135914,
-0.0019597753416746855,
0.003805448766797781,
0.023844189941883087,
-0.0016714369412511587,
0.01573987863957882,
-0.05185772106051445,
0.0032842811197042465,
0.009831256233155727,
-0.058272089809179306,
-0.07889676094055176,
0.005427544470876455,
-0.08901172876358032,
-0.020624669268727303,
-0.015271136537194252,
0.014111615717411041,
-0.02002023719251156,
-0.008412693627178669,
-0.003518652403727174,
-0.008054968900978565,
0.00474293390288949,
-0.01698574610054493,
-0.017207782715559006,
0.019292453303933144,
-0.009658562019467354,
0.020649340003728867,
-0.054226104170084,
-0.003281197277829051,
0.053831372410058975,
0.003287364961579442,
0.05925891548395157,
0.005368951708078384,
0.01534514781087637,
-0.05003209039568901,
0.035846464335918427,
-0.01602359116077423,
-0.0023514218628406525,
-0.010232154279947281,
0.012656047008931637,
0.00562490988522768,
-0.04828047379851341,
-0.04657819867134094,
-0.02362215332686901,
-0.005813023541122675,
-0.002167933853343129,
-0.011737064458429813,
-0.01480239350348711,
0.026891015470027924,
0.061429932713508606,
0.02204323187470436,
-0.0024069310165941715,
-0.004699760116636753,
0.0006610964774154127,
-0.022721674293279648,
0.004863203037530184,
0.043494366109371185,
-0.004647335037589073,
0.027063710615038872,
-0.00468125706538558,
-0.024226585403084755,
-0.014679040759801865,
0.027458440512418747,
-0.028889339417219162,
-0.0017361973877996206,
0.027039039880037308,
-0.0338728129863739,
0.016245627775788307,
-0.0011664595222100616,
-0.009294670075178146,
0.058568138629198074,
0.03670993819832802,
-0.06078849732875824,
-0.02425125613808632,
-0.025225745514035225,
0.006513053085654974,
-0.008708741515874863,
0.0819559171795845,
-0.04596143215894699,
0.02188287302851677,
0.004215598572045565,
-0.019033411517739296,
-0.00015785364666953683,
-0.014901076443493366,
0.011854249984025955,
-0.0280752070248127,
-0.08235064893960953,
-0.002192604588344693,
-0.00990526843816042,
-0.019329458475112915,
0.011052453890442848,
0.021870536729693413,
0.010768741369247437,
-0.024177243933081627,
0.007364191114902496,
0.059604305773973465,
0.01083658542484045,
-0.013901914469897747,
-0.015542513690888882,
0.011817244812846184,
-0.046948257833719254,
-0.007413532119244337,
-0.022943710908293724,
-0.05111759901046753,
0.009566047228872776,
0.009652393870055676,
0.01129299309104681,
0.02546011656522751,
-0.01559185516089201,
0.054916881024837494,
-0.031331732869148254,
-0.026668978855013847,
-0.02637293189764023,
-0.0400158055126667,
0.030862990766763687,
0.00007116905908333138,
0.014173291623592377,
-0.002787784207612276,
-0.02316574566066265,
-0.03915233165025711,
-0.00820299331098795,
0.011539699509739876,
-0.027754489332437515,
-0.028543949127197266,
0.005011226981878281,
0.028839997947216034,
0.013050776906311512,
-0.020044907927513123,
-0.06271281093358994,
0.015764549374580383,
-0.011934430338442326,
0.021105745807290077,
-0.01702275313436985,
-0.00930083729326725,
0.012020776979625225,
-0.006254011299461126,
-0.011743232607841492,
-0.04524598270654678,
0.03150442987680435,
-0.024757003411650658,
0.008301676250994205,
0.005112993530929089,
-0.043913766741752625,
-0.023819519206881523,
-0.0011047828011214733,
0.042088139802217484,
-0.051216281950473785,
0.009960777126252651,
0.050969574600458145,
0.026668978855013847,
-0.006312604062259197,
-0.0008719534962438047,
0.009214489720761776,
0.003293532645329833,
-0.004958801902830601,
0.00005228058944339864,
-0.013852573931217194,
0.0186016745865345,
-0.011872753500938416,
-0.055953048169612885,
-0.014938082545995712,
-0.016035927459597588,
0.0003172492142766714,
0.0014609654899686575,
0.010633053258061409,
-0.002821706235408783,
-0.01984754391014576,
0.051462989300489426,
-0.02906203269958496,
0.052548497915267944,
-0.012427843175828457,
0.029530774801969528,
0.02316574566066265,
-0.013013770803809166,
-0.03939903900027275,
-0.04551736265420914,
0.01610993780195713,
-0.008239999413490295,
0.0012836450478062034,
-0.017664190381765366,
0.03799280896782875,
-0.026298919692635536,
-0.0001703817251836881,
0.004943382926285267,
0.047688379883766174,
-0.02267233282327652,
0.006580897606909275,
0.005276436451822519,
0.04731832072138786,
0.027211733162403107,
0.019132094457745552,
0.01844131574034691,
0.03762274980545044,
0.01781221479177475,
0.018947064876556396,
0.011367005296051502,
-0.00957221444696188,
0.01525880116969347,
0.007277843542397022,
-0.03503233194351196,
0.018169937655329704,
-0.037055324763059616,
0.021771853789687157,
0.03592047467827797,
0.023696165531873703,
-0.02528742328286171,
0.017960237339138985,
-0.03779544681310654,
-0.05965364724397659,
-0.047688379883766174,
0.006207753904163837,
0.029826823621988297,
0.03160310909152031,
-0.04038586467504501,
0.010984609834849834,
0.024596644565463066,
-0.011952932924032211,
0.02267233282327652,
-0.02200622484087944,
0.03550107404589653,
-0.01627029851078987,
0.041125982999801636,
-0.044037122279405594,
0.0014571106294170022,
0.01628263294696808,
0.04354370757937431,
-0.03633987531065941,
-0.09434059262275696,
0.033897481858730316,
0.01872502826154232,
-0.04339568316936493,
-0.0036790117155760527,
-0.02595353126525879,
-0.017220119014382362,
0.04376574605703354,
-0.034316882491111755,
0.06443975120782852,
0.061923347413539886,
0.0405338890850544,
-0.040163829922676086,
-0.012730058282613754,
-0.02923472784459591,
-0.034736283123493195,
0.031085027381777763,
-0.055360954254865646,
0.026891015470027924,
0.015382153913378716,
0.05240047350525856,
-0.05244981497526169,
-0.005032814107835293,
0.04201412945985794,
0.006648741662502289,
-0.011286824941635132,
-0.00031647825380787253,
-0.050180114805698395,
-0.03333005681633949,
0.03732670471072197,
0.010984609834849834,
0.010910597629845142,
-0.017738202586770058,
-0.037228021770715714,
-0.00015390249609481543,
-0.0661666989326477,
-0.012131795287132263,
0.01963784173130989,
-0.008388022892177105,
0.01739281229674816,
0.02595353126525879,
-0.06281149387359619,
-0.02511472813785076,
0.05975233018398285,
0.01056520827114582,
-0.03266394883394241,
-0.01124981977045536,
0.036685265600681305,
-0.03384814038872719,
0.034440238028764725,
-0.04504861682653427,
0.03811616450548172,
-0.021118082106113434,
-0.007617065217345953,
-0.02570682391524315,
-0.005655747838318348,
0.017540836706757545,
0.04157005622982979,
0.0216731708496809,
-0.031405746936798096,
-0.0072161671705543995,
-0.03268862143158913,
-0.020822033286094666,
-0.007364191114902496,
0.01504910085350275,
-0.018823711201548576,
-0.0052733528427779675,
-0.0356244295835495,
0.0640450268983841,
-0.008024130947887897,
0.01615927927196026,
0.009103472344577312,
0.034489575773477554,
-0.007462873589247465,
-0.012538861483335495,
-0.021266106516122818,
-0.030591614544391632,
0.0005855425843037665,
0.00027330461307428777,
-0.00407065823674202,
0.0171954482793808,
-0.004440718330442905,
-0.006146077066659927,
-0.00709898117929697,
-0.001235074712894857,
-0.01831796206533909,
-0.021241435781121254,
0.048601191490888596,
0.009479699656367302,
0.007413532119244337,
0.024510297924280167,
0.005600239150226116,
-0.014457005076110363,
0.00909113697707653,
0.0025688321329653263,
-0.009769580326974392,
0.036019157618284225,
0.04260622337460518,
0.007234669756144285,
0.022191256284713745,
0.018293291330337524,
0.009880597703158855,
0.011360837146639824,
-0.011181974783539772,
0.03873293101787567,
-0.012273651547729969,
-0.006543891504406929,
0.011496526189148426,
0.09088669717311859,
-0.009288501925766468,
-0.0507228709757328,
-0.006630239076912403,
-0.016726704314351082,
0.011619878932833672,
-0.0025996703188866377,
0.027951853349804878,
0.05259783938527107,
0.02923472784459591,
0.012915088795125484,
0.0018071256345137954,
0.0004752956156153232,
0.020945386961102486,
-0.013075447641313076,
0.016134608536958694,
-0.024275925010442734,
-0.011453351937234402,
0.007512215059250593,
-0.030616285279393196,
-0.03209652379155159,
-0.007832933217287064,
-0.030961673706769943,
0.014308980666100979,
0.0025688321329653263,
-0.003416885854676366,
-0.00594871211796999,
0.026175566017627716,
-0.004971137270331383,
-0.019539160653948784,
-0.019576165825128555,
-0.05235113203525543,
-0.014740717597305775,
-0.07060741633176804,
0.032787300646305084,
-0.016048261895775795,
0.03453891724348068,
0.05945628136396408,
-0.0302708949893713,
-0.042211491614580154,
0.02130311168730259,
0.009060298092663288,
-0.004499311093240976,
-0.0003353667270857841,
0.02681700326502323,
0.0027399847749620676,
0.02358514815568924,
-0.019921554252505302,
0.011866585351526737,
0.022820357233285904,
0.018552333116531372,
-0.014975088648498058,
0.019156765192747116,
-0.0069509572349488735,
0.06241676211357117,
-0.0293087400496006,
0.04105197265744209,
-0.013889579102396965,
-0.01179257407784462,
-0.0060813166201114655,
0.0024608979001641273,
0.005331945605576038,
0.009140478447079659,
0.0027415265794843435,
-0.0450979582965374,
0.007018801756203175,
0.005572484340518713,
-0.036931972950696945,
-0.0061553288251161575,
-0.01330981869250536,
0.011823412030935287,
-0.0013006061781197786,
0.0003823951701633632,
0.023511135950684547,
-0.01498742401599884,
-0.014938082545995712,
0.007518382743000984,
-0.015912573784589767,
0.0450979582965374,
0.009516705758869648,
-0.028420595452189445,
0.011237484402954578,
0.006704250816255808,
0.0002777376212179661,
-0.00980041828006506,
-0.003901047632098198,
-0.00973874144256115,
0.006025807932019234,
-0.03355209156870842,
0.0008919984102249146,
-0.020155927166342735,
-0.022746345028281212,
0.00024227355606853962,
0.009350178763270378,
0.020772691816091537,
-0.03707999736070633,
0.0463314913213253,
0.03500766307115555,
-0.019946224987506866,
-0.0062694307416677475,
-0.009664729237556458,
-0.01586323231458664,
-0.017676524817943573,
-0.00037584203528240323,
0.024843350052833557,
-0.008110478520393372,
-0.01976119540631771,
-0.010848920792341232,
0.023782512173056602,
0.011323831044137478,
-0.001822544727474451,
-0.04134802147746086,
-0.007043472491204739,
-0.0072099994868040085,
0.016183950006961823,
0.025484787300229073,
-0.004758352879434824,
0.002373008755967021,
0.008727245032787323,
-0.020168261602520943,
-0.01370454952120781,
-0.016208620741963387,
0.019243111833930016,
-0.03226921707391739,
-0.031701792031526566,
0.007148322649300098,
-0.012033112347126007,
-0.020748021081089973,
-0.014605028554797173,
-0.05634777992963791,
-0.006260178983211517,
-0.014234968461096287,
-0.019169099628925323,
0.00551080796867609,
-0.0096955681219697,
-0.028617961332201958,
-0.00566808320581913,
0.01135466992855072,
-0.004931047558784485,
-0.025053052231669426,
0.0034199696965515614,
-0.012625208124518394,
0.017923232167959213,
-0.005794520489871502,
0.008418861776590347,
0.006506885401904583,
-0.0026628889609128237,
-0.01831796206533909,
0.03333005681633949,
-0.028963349759578705,
-0.034686941653490067,
-0.004385209176689386,
0.02698969841003418,
-0.025065386667847633,
-0.021155087277293205,
-0.03221987560391426,
0.008899939246475697,
-0.005442963447421789,
0.007284011226147413,
-0.007308681961148977,
-0.0020199099089950323,
0.005612574517726898,
0.03350275009870529,
0.05368334800004959,
-0.037721432745456696,
0.022154249250888824,
-0.029012691229581833,
-0.004431466571986675,
0.02009424939751625,
0.013026106171309948,
0.019921554252505302,
0.001132537261582911,
-0.018502991646528244,
0.003774610348045826,
0.05659448727965355,
0.003019071649760008,
0.052055083215236664,
0.0028695056680589914,
-0.007321017328649759,
0.016665028408169746,
0.005131496582180262,
-0.030073530972003937,
-0.023683829233050346,
-0.007580059114843607,
-0.0004579490632750094,
-0.01376622635871172,
-0.028716644272208214,
-0.0155301783233881,
-0.0004884019144810736,
-0.012915088795125484,
0.02263532765209675,
-0.007937783375382423,
-0.005874699912965298,
-0.01623329147696495,
-0.003651257138699293,
-0.019909219816327095,
-0.020106585696339607,
0.0053288619965314865,
0.012051615864038467,
0.041125982999801636,
0.00039357406785711646,
0.019958561286330223,
-0.025805506855249405,
-0.025053052231669426,
0.02042730338871479,
0.04322298988699913,
-0.015727544203400612,
0.01173089724034071,
0.013889579102396965,
0.007697244640439749,
-0.024016883224248886,
-0.004422215279191732,
0.02523808181285858,
0.00807963963598013,
0.004746017511934042,
-0.0019721107091754675,
-0.022030895575881004,
0.002590419026091695,
-0.02047664485871792,
-0.014333651401102543,
-0.004511646460741758,
0.04250754043459892,
0.010861256159842014,
0.017380477860569954,
-0.013359160162508488,
0.010108801536262035,
-0.009189819917082787,
-0.027335086837410927,
0.027631135657429695,
0.04961268976330757,
-0.0136428726837039,
0.051216281950473785,
-0.015998920425772667,
-0.014247303828597069,
-0.008659400045871735,
-0.007296346593648195,
0.005112993530929089,
0.025225745514035225,
-0.036931972950696945,
0.029826823621988297,
0.00909113697707653,
0.000057243632909376174,
0.001970568671822548,
-0.01337149553000927,
0.022487303242087364,
-0.027927182614803314,
-0.01310011837631464,
0.03217053413391113,
-0.029407422989606857,
0.024275925010442734,
0.01802191510796547,
-0.022906703874468803,
0.0310603566467762,
-0.03989244997501373,
-0.02525041624903679,
0.009578382596373558,
-0.02565748244524002,
0.004388292785733938,
0.020834369584918022,
0.007567723747342825,
-0.021068740636110306,
0.008499041199684143,
-0.01914442889392376,
0.006287933327257633,
-0.014901076443493366,
0.023227423429489136,
0.033157363533973694,
-0.007382693700492382,
0.013420837000012398,
0.004650418646633625,
-0.022314608097076416,
0.02225293219089508,
-0.009448861703276634,
0.07085412740707397,
0.006513053085654974,
-0.007641735952347517,
-0.005412125028669834,
-0.012255148962140083,
0.0043081133626401424,
-0.012705388478934765,
-0.010996945202350616,
-0.02337544783949852,
0.012612872757017612,
0.04213748127222061,
0.0029188471380621195,
0.006371196825057268,
-0.0012836450478062034,
-0.01513544749468565,
-0.008233831264078617,
-0.02134011685848236,
-0.014543351717293262,
0.01039868127554655,
-0.0005107597098685801,
-0.0007886900566518307,
-0.029333410784602165,
0.025028381496667862,
-0.031282391399145126,
0.058518797159194946,
-0.022561315447092056,
0.03342873975634575,
0.008918441832065582,
-0.10203783214092255,
-0.038017481565475464,
-0.009726406075060368,
0.009128143079578876,
0.021734848618507385,
0.008283172734081745,
0.005103742238134146,
-0.01602359116077423,
0.015924908220767975,
-0.016837723553180695,
0.006223172880709171,
0.00036408493178896606,
0.014765387400984764,
-0.010053292848169804,
0.0293087400496006,
-0.039004307240247726,
-0.006722753867506981,
-0.057778678834438324,
0.020748021081089973,
0.013568861410021782,
-0.015505507588386536,
0.028543949127197266,
-0.02637293189764023,
0.022845027968287468,
-0.02042730338871479,
0.007820597849786282,
-0.021599160507321358,
-0.019156765192747116,
-0.009892933070659637,
0.018922394141554832,
0.00809814315289259,
-0.006827604025602341,
-0.024645986035466194,
0.06517987698316574,
-0.03325604647397995,
-0.0526471808552742,
0.01062688510864973,
-0.02935808151960373,
0.02478167414665222,
-0.013679878786206245,
0.02923472784459591,
0.025608140975236893,
-0.01162604708224535,
0.007080478593707085,
-0.03910299018025398,
-0.02163616567850113,
-0.030665626749396324,
0.005085239186882973,
0.006938622333109379,
-0.01872502826154232,
0.024177243933081627,
-0.011009280569851398,
-0.0356244295835495,
0.010707064531743526,
-0.02583017759025097,
-0.03782011568546295,
0.018256286159157753,
0.0449252650141716,
0.011786405928432941,
0.026891015470027924,
0.0052270954474806786,
0.030048860237002373,
0.022697003558278084,
-0.004863203037530184,
-0.008480537682771683,
-0.004163173492997885,
-0.007006466388702393,
0.004067574627697468,
-0.0032719457522034645,
-0.002963562496006489,
-0.017664190381765366,
0.03952239081263542,
-0.05916023254394531,
0.022734010592103004,
-0.013877244666218758,
0.011471855454146862,
0.006691915448755026,
0.017824549227952957,
-0.02267233282327652,
0.022067902609705925,
-0.03503233194351196,
-0.04418514668941498,
-0.014901076443493366,
0.009664729237556458,
-0.004227933939546347,
0.008042633533477783,
0.017405148595571518,
0.005640328861773014,
-0.0029851493891328573,
-0.010947603732347488,
0.01156437024474144,
-0.03150442987680435,
-0.020624669268727303,
0.017947902902960777,
-0.011181974783539772,
-0.018651016056537628,
-0.03221987560391426,
0.007339520379900932,
-0.006593232974410057,
0.008375687524676323,
0.034144189208745956,
-0.020772691816091537,
-0.021747183054685593,
-0.032244548201560974,
-0.02558347024023533,
-0.014851734973490238,
0.03014754131436348,
-0.003774610348045826,
-0.01607293263077736,
0.008277005515992641,
0.0642423927783966,
0.03347808122634888,
0.0037067660596221685,
-0.0003222604573238641,
0.0067782630212605,
-0.01108329277485609,
0.05506490543484688,
-0.02283269166946411,
-0.014419998973608017,
0.006537723820656538,
0.0545714907348156,
0.021734848618507385,
0.005427544470876455,
0.024312932044267654,
0.008153651840984821,
0.008209160529077053,
0.041372690349817276,
0.02748311124742031,
0.01710909977555275,
-0.003179430728778243,
-0.010145807638764381,
-0.030492931604385376,
0.0072038318030536175,
-0.008659400045871735,
-0.021241435781121254,
0.025805506855249405,
0.03429221361875534,
0.043741073459386826,
-0.030344907194375992,
0.019465148448944092,
-0.010207484476268291,
0.005427544470876455,
-0.0028494608122855425,
-0.018280956894159317,
0.009411855600774288,
-0.019329458475112915,
-0.044407181441783905,
0.00957221444696188,
0.012865747325122356,
-0.004468472674489021,
-0.009208322502672672,
0.00528260413557291,
0.04305029660463333,
0.023597482591867447,
0.013864909298717976,
0.026052212342619896,
0.008566885255277157,
0.004764520563185215,
-0.02428826130926609,
0.004860119428485632,
0.004604161251336336,
-0.002496361965313554,
-0.0436917319893837,
-0.01918143592774868,
0.021352453157305717,
0.004502394702285528,
-0.02437460795044899,
0.007956286892294884,
0.015480836853384972,
0.03379879891872406,
0.008073472417891026,
-0.06483448296785355,
0.030048860237002373,
0.0356244295835495,
-0.00577293336391449,
0.014913411810994148,
0.045862749218940735,
-0.0002104715385939926,
0.014901076443493366,
0.03266394883394241,
-0.0005681960610672832,
0.004955718293786049,
0.019699519500136375,
0.011157304048538208,
0.04455520585179329,
-0.01702275313436985,
0.015295807272195816,
-0.04085460677742958,
0.03870825842022896,
0.01112646609544754,
-0.022203590720891953,
-0.01295209489762783,
0.027631135657429695,
0.03451424837112427,
0.03379879891872406,
0.0007817514124326408,
0.0025256583467125893,
0.017886225134134293,
-0.022906703874468803,
-0.03379879891872406,
-0.015098441392183304,
0.01546850148588419,
0.02200622484087944,
-0.018675686791539192,
-0.013938920572400093,
0.014432334341108799,
0.02674299106001854,
-0.030172212049365044,
-0.023054728284478188,
0.05156167224049568,
0.014629699289798737,
0.04206347092986107,
-0.02428826130926609,
-0.02528742328286171,
0.02657029777765274,
0.02354814112186432,
-0.0005631848471239209,
0.0016267213504761457,
-0.029012691229581833,
-0.011866585351526737,
-0.023264428600668907,
-0.030665626749396324,
0.0071668257005512714,
-0.009498202241957188,
-0.00555398128926754,
-0.016714369878172874,
0.0005739782354794443,
0.003716017585247755,
0.0008758082985877991,
0.028963349759578705,
-0.021019399166107178,
0.027187062427401543,
-0.010003951378166676,
0.006210837513208389,
0.0302708949893713,
0.005606406833976507,
0.004721346776932478,
0.011465687304735184,
-0.006321855820715427,
0.016751375049352646,
0.008314011618494987,
-0.0009814295917749405,
-0.002243487862870097,
-0.02367149479687214,
0.0021848951000720263,
0.0027014368679374456,
0.02657029777765274,
-0.0008935403311625123,
-0.014580357819795609,
-0.014962753280997276,
-0.013346824795007706,
-0.008542214520275593,
-0.0013792439131066203,
0.00704964017495513,
0.02578083612024784,
0.04393843933939934,
0.021438799798488617,
0.006624071393162012,
0.035402391105890274,
0.0021663920488208532,
-0.004551736172288656,
-0.02583017759025097,
-0.02495436929166317,
-0.0405338890850544,
-0.009387184865772724,
-0.017121436074376106,
0.0039041314739733934,
-0.017836883664131165,
0.04504861682653427,
0.0164059866219759,
0.025053052231669426,
0.018342632800340652,
-0.052301790565252304,
0.005236346740275621,
-0.00395655632019043,
-0.0255341287702322,
0.01581389084458351,
0.0026181733701378107,
0.01546850148588419,
0.005631077103316784,
-0.007111316546797752,
-0.014333651401102543,
-0.021414129063487053,
0.00572976004332304,
0.0012258231872692704,
-0.02923472784459591,
-0.00200911657884717,
0.0028556284960359335,
0.028099877759814262,
-0.016788382083177567,
-0.022561315447092056,
0.016430657356977463,
-0.005917873699218035,
-0.02039029821753502,
-0.012384669855237007,
-0.04499927908182144,
-0.006389699876308441,
0.0009212948498316109,
0.015542513690888882,
-0.04541867971420288,
0.03239257261157036,
0.004601077642291784,
-0.033034007996320724,
0.001676062704063952,
0.015382153913378716,
-0.016418321058154106,
-0.010768741369247437,
-0.05092023313045502,
0.052548497915267944,
-0.0005362012889236212,
-0.031035685911774635,
-0.003561825957149267,
0.021364787593483925,
-0.01581389084458351,
0.019070416688919067,
0.028667302802205086,
-0.02657029777765274,
0.005362784024327993,
-0.018984070047736168,
0.0185153279453516,
-0.022203590720891953,
0.021648500114679337,
0.02191987819969654,
-0.0017932483460754156,
-0.007277843542397022,
-0.02486802078783512,
0.007111316546797752,
-0.009942274540662766,
0.01573987863957882,
-0.0023360028862953186,
0.01988454908132553,
-0.0015866316389292479,
-0.01194059755653143,
0.0052024247124791145,
0.007154490333050489,
0.017084429040551186,
-0.006432873662561178,
-0.04433317109942436,
0.010324670001864433,
-0.0005165418842807412,
-0.04971137270331383,
0.00566808320581913,
0.01223047822713852,
0.020168261602520943,
0.014296645298600197,
0.017306465655565262,
0.016541674733161926,
0.014975088648498058,
-0.011663053184747696,
-0.01112646609544754,
0.059604305773973465,
-0.01881137490272522,
-0.0061491611413657665,
0.048971254378557205,
0.024263590574264526,
0.023819519206881523,
0.03673460707068443,
0.012804070487618446,
-0.007573891431093216,
0.004560987465083599,
-0.032195206731557846,
0.014481674879789352,
0.022289937362074852,
-0.007413532119244337,
0.00028274886426515877,
0.021044069901108742,
-0.04231017455458641,
-0.01776287332177162,
-0.007900777272880077,
-0.02034095674753189,
0.03397149220108986,
0.03283664211630821,
-0.025558799505233765,
-0.005038981791585684,
0.008807424455881119,
-0.00904796365648508,
0.04435783997178078,
-0.005865448620170355,
0.007549220696091652,
0.006170747801661491,
0.019576165825128555,
-0.01635664515197277,
0.002342170337215066,
-0.011619878932833672,
0.0060227238573133945,
-0.014049938879907131,
0.002935808151960373,
-0.01322347205132246,
-0.001528809778392315,
0.003543322905898094,
-0.0008002544054761529,
-0.02200622484087944,
0.008418861776590347,
-0.008227664045989513,
-0.009035628288984299,
-0.02354814112186432,
-0.00936251413077116,
-0.007438202854245901,
-0.021155087277293205,
-0.0032441914081573486,
-0.01702275313436985,
0.011317663826048374,
0.01789856143295765,
-0.005008143372833729,
0.027014369145035744,
-0.0021386374719440937,
0.02328909933567047,
-0.01831796206533909,
-0.011817244812846184,
-0.004672005772590637,
-0.015912573784589767,
0.028247902169823647,
-0.027631135657429695,
-0.006266346666961908,
-0.014740717597305775,
0.007259340491145849,
-0.02669364959001541,
-0.018169937655329704,
0.0021340118255466223,
-0.004823113325983286,
-0.022721674293279648,
-0.007135987281799316,
0.017244787886738777,
-0.004434550646692514,
-0.031455088406801224,
0.008566885255277157,
0.00809814315289259,
0.01831796206533909,
0.003774610348045826,
0.03402083367109299,
0.016973411664366722,
-0.020772691816091537,
0.03476095572113991,
-0.027877841144800186,
-0.025336764752864838,
-0.004215598572045565,
0.00743203517049551,
0.013605866581201553,
-0.030122870579361916,
0.005652664229273796,
0.004931047558784485,
0.025879519060254097,
-0.003638921771198511,
0.04280358925461769,
-0.004258771892637014,
-0.03476095572113991,
0.014247303828597069,
-0.011157304048538208,
0.0069632926024496555,
0.04097795858979225,
0.015456166118383408,
0.0529925711452961,
-0.00952904112637043,
0.01223047822713852,
-0.021599160507321358,
0.009670897386968136,
-0.022697003558278084,
-0.01480239350348711,
0.014358322136104107,
0.03318203240633011,
-0.02295604534447193,
0.004850867670029402,
-0.008406526409089565,
0.02832191437482834,
-0.034859638661146164,
0.007506047375500202,
-0.018219279125332832,
0.0052980235777795315,
-0.008233831264078617,
-0.020711015909910202,
0.01243401039391756,
0.014382992871105671,
-0.004323532339185476,
0.005735927727073431,
0.020414968952536583,
-0.021734848618507385,
0.03147975727915764,
0.0025734577793627977,
-0.0021494310349226,
0.007154490333050489,
-0.009899101220071316,
0.025213411077857018,
0.0020892962347716093,
0.007345688063651323,
0.01784921996295452,
0.006133742164820433,
-0.0042803590185940266,
-0.05679184943437576,
0.02935808151960373,
-0.0028510026168078184,
-0.0043512871488928795,
-0.0028957182075828314,
-0.023437123745679855,
-0.018490657210350037,
0.01628263294696808,
0.02911137416958809,
0.0013283606385812163,
-0.011151136830449104,
0.010559041053056717,
-0.011367005296051502,
-0.012440178543329239,
0.007302514277398586,
0.0030869159381836653,
0.030961673706769943,
0.0015496256528422236,
-0.019033411517739296,
-0.025386106222867966,
-0.08516310900449753,
-0.00015814276412129402,
0.020032573491334915,
-0.016702033579349518,
-0.0012751645408570766,
-0.002955853007733822,
0.012464849278330803,
0.019539160653948784,
-0.05427544564008713,
-0.0012851869687438011,
0.002736900933086872,
0.00327502959407866,
0.012705388478934765,
-0.0013538022758439183,
0.047441672533750534,
0.019193770363926888,
-0.0465041883289814,
-0.028864668682217598,
-0.01432131603360176,
-0.02362215332686901,
-0.002308248309418559,
-0.011829580180346966,
0.015172453597187996,
0.05693987384438515,
-0.00008808194979792461,
0.007586226798593998,
-0.049760714173316956,
-0.016467662528157234,
0.01322347205132246,
-0.023634489625692368,
-0.007808262947946787,
-0.002073877025395632,
-0.003197933780029416,
-0.0024023051373660564,
-0.004980388563126326,
0.0545714907348156,
-0.0035587421152740717,
0.024300595745444298,
0.014814728870987892,
0.01893472857773304,
-0.018799040466547012,
-0.0010438770987093449,
0.025484787300229073,
0.03441556543111801,
-0.017997244372963905,
0.010293831117451191,
0.0017732033738866448,
-0.042088139802217484,
-0.00023841876827646047,
-0.00047375369467772543,
-0.01776287332177162,
-0.032614607363939285,
-0.004597993567585945,
0.030492931604385376,
0.004869370721280575,
0.014827064238488674,
0.04625748097896576,
-0.018614010885357857,
-0.007863772101700306,
0.010848920792341232,
-0.03986778110265732,
-0.0593082569539547,
-0.013396166265010834,
-0.013741555623710155,
-0.029086703434586525,
-0.02523808181285858,
-0.023683829233050346,
-0.03379879891872406,
0.015369818545877934,
0.005760598462074995,
0.008973951451480389,
-0.0026767661329358816,
0.011681555770337582,
-0.008332514204084873,
0.024929698556661606,
-0.012316824868321419,
-0.01519712433218956,
-0.015505507588386536,
0.0016544759273529053,
0.00021316988568287343,
-0.00566808320581913,
-0.03180047497153282,
-0.01810826174914837,
-0.07238370925188065,
0.003147050505504012,
0.014765387400984764,
-0.02205556631088257,
-0.017799878492951393,
0.02977748215198517,
0.002457814058288932,
-0.013655208051204681,
-0.01249568723142147,
0.003318203380331397,
0.005526226945221424,
-0.03609317168593407,
0.006593232974410057,
-0.03357676416635513,
-0.003780778031796217,
-0.029382752254605293,
-0.003922634292393923,
-0.014777722768485546,
-0.025336764752864838,
0.00566808320581913,
-0.0605417899787426,
-0.007376526482403278,
-0.006059729959815741,
0.03646323084831238,
0.009442693553864956,
0.03779544681310654,
-0.03732670471072197,
-0.0027322752866894007,
0.014543351717293262,
-0.017577841877937317,
0.039843108505010605,
0.03934969753026962,
-0.01195910107344389,
-0.003157844068482518,
0.033897481858730316,
0.012551196850836277,
-0.005523143336176872,
0.029999518766999245,
0.013198801316320896,
-0.002602754160761833,
-0.006284849718213081,
0.005520059261471033,
0.008351016789674759,
-0.008215328678488731,
-0.016171615570783615,
-0.003962724003940821,
-0.018404310569167137,
0.03920167312026024,
-0.03981843963265419,
0.0069632926024496555,
-0.01914442889392376,
0.008690238930284977,
0.0038424546364694834,
0.03152909874916077,
-0.04055855795741081,
0.01930478774011135,
-0.014876405708491802,
0.007253172807395458,
0.016331974416971207,
0.0088197598233819,
-0.021327782422304153,
0.039053648710250854,
0.01156437024474144,
0.011132633313536644,
0.008085807785391808,
0.01830562762916088,
0.033650774508714676,
0.0011410178849473596,
0.0026829338166862726,
0.01768886111676693,
0.016751375049352646,
-0.0030560775194317102,
0.008184489794075489,
0.01805892027914524,
-0.00556323304772377,
0.011410178616642952,
0.015752214938402176,
0.0338728129863739,
-0.032787300646305084,
-0.004443801939487457,
-0.031233051791787148,
0.004240268841385841,
-0.00327502959407866,
0.008017963729798794,
0.10411016643047333,
-0.004789191298186779,
-0.01751616597175598,
0.010417184792459011,
-0.022869698703289032,
-0.00888143666088581,
0.054078079760074615,
0.025151733309030533,
0.0034847301431000233,
-0.025312094017863274,
0.02681700326502323,
0.027458440512418747,
0.02212957851588726,
0.022474968805909157,
0.033774130046367645,
0.0006819123518653214,
-0.030986344441771507,
0.032910656183958054,
-0.014382992871105671,
-0.0004537087806966156,
-0.025262752547860146,
0.017096765339374542,
-0.0126807177439332,
-0.005646496545523405,
-0.003076122375205159,
-0.0029651045333594084,
0.008961616083979607,
-0.029629457741975784,
0.014049938879907131,
-0.007943951524794102,
0.03493364900350571,
0.00776508916169405,
-0.019415806978940964,
-0.03458825871348381,
-0.004641167353838682,
-0.002302080625668168,
-0.025608140975236893,
-0.03552574664354324,
0.008196825161576271,
0.016011256724596024,
0.028790656477212906,
-0.010978441685438156,
0.01100311242043972,
0.01677604578435421,
0.0246583204716444,
0.003185598412528634,
-0.02893867902457714,
0.017158441245555878,
0.0177258662879467,
-0.016591016203165054,
-0.002844835165888071,
-0.004335867706686258,
0.023190416395664215,
-0.033280715346336365,
0.023178081959486008,
-0.01979820244014263,
0.010953771881759167,
0.00022396330314222723,
-0.019699519500136375,
-0.03537772223353386,
-0.027680477127432823,
-0.006833771709352732,
0.035649098455905914,
0.004008981864899397,
-0.015283471904695034
] | 2025-01-17 | 1 | 39820712 | [
"NKT memory differentiation",
"GD2.CAR NKTs",
"central memory differentiation",
"NKT therapeutic activity",
"NKT functional fitness",
"PRDM1 knockout",
"targeted PRDM1 knockout",
"CAR NKTs",
"vivo antitumor activity",
"NKTs",
"PRDM1",
"NKT",
"Natural killer T cells",
"gRNA abundance",
"effector function",
"cancer immunotherapy",
"GD2.CAR",
"few genes",
"CD1d-GD2+ neuroblastoma cells",
"NKT-based cancer immunotherapies",
"central memory-like differentiation",
"Unmodified NKTs",
"PRDM1-specific gRNAs",
"-mediated PRDM1 knockdown",
"both NKTs and GD2.CAR NKTs",
"regulators",
"the cytotoxic mediator granzyme B",
"the gRNA library",
"leukemia",
"RNA"
] | [] | 0 | 10.1158/2326-6066.CIR-24-0259 | [
"Tian",
"Barragán",
"Yu",
"Martinez-Amador",
"Adaikkalavan",
"Rios",
"Guo",
"Drabek",
"Pardias",
"Xu",
"Montalbano",
"Zhang",
"Li",
"Courtney",
"Di Pierro",
"Metelitsa"
] | [
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, Texas, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, Texas, United States.",
"Baylor College of Medicine, Houston, TX, United States.",
"Baylor College of Medicine, Houston, TX, United States."
] | [
"39820712"
] | [] | 11.209931 | 5.928877 |
39820375 | 19 | The emergence of bispecific T-cell engagers in the treatment of follicular and large B-cell lymphomas. | The rapid emergence of CD20-targeting T-cell engagers in follicular lymphoma and large B-cell lymphoma has further expanded the treatment options for patients with relapsed or refractory disease. Herein, we review and discuss the standard-of-care products and indications for mosunetuzumab, epcoritamab, and glofitamab. We provide a detailed overview of the registrational clinical trials, as well as a review of ongoing trials and likely future indications. We also address how we incorporate T-cell engagers in our current treatment paradigm, with particular emphasis on their use with and as alternatives to chimeric antigen receptor T-cell therapy. We further discuss our management of immune effector cell-related toxicities. | [
0.019870135933160782,
0.010344400070607662,
0.04219626262784004,
0.02797490544617176,
-0.029612233862280846,
0.02577620930969715,
0.0035261011216789484,
0.05744679644703865,
0.017601268365979195,
-0.02045489475131035,
0.009853201918303967,
-0.027694221585989,
-0.04579838365316391,
0.009075471200048923,
0.029518671333789825,
-0.0033506732434034348,
0.019519280642271042,
-0.012127917259931564,
-0.023156486451625824,
0.04214948043227196,
0.009636840783059597,
0.023600902408361435,
-0.015811903402209282,
-0.016431748867034912,
-0.05941158905625343,
-0.020396418869495392,
-0.03244246914982796,
0.03950636833906174,
-0.01235012523829937,
-0.03143668174743652,
0.03800938278436661,
-0.02593994140625,
-0.007666199933737516,
0.009671925567090511,
-0.015309009701013565,
0.04278102144598961,
0.008233416825532913,
0.031460072845220566,
-0.024068711325526237,
0.0114203579723835,
0.015940550714731216,
0.0015072182286530733,
0.030781753361225128,
0.033892672508955,
-0.020419809967279434,
-0.008707072585821152,
0.026781996712088585,
-0.07339904457330704,
0.013554730452597141,
-0.014677469618618488,
-0.02788134478032589,
0.02189340442419052,
-0.028887130320072174,
0.022793933749198914,
-0.04986831173300743,
0.007075592875480652,
0.024747032672166824,
0.04626619070768356,
-0.0026928186416625977,
0.0016709509072825313,
0.005318389739841223,
0.0009209965937770903,
0.04958762601017952,
-0.014443565160036087,
-0.052721936255693436,
0.014174575917422771,
-0.06605446338653564,
-0.028208808973431587,
-0.015297315083444118,
-0.007028812076896429,
0.016618872061371803,
-0.027249803766608238,
0.015168667770922184,
0.019273681566119194,
0.02302783913910389,
0.015203753486275673,
0.018759092316031456,
0.023881588131189346,
-0.007824085652828217,
-0.04388036951422691,
0.021203387528657913,
0.012022660113871098,
-0.015121886506676674,
-0.020770665258169174,
0.0061809103935956955,
0.011028568260371685,
0.023343607783317566,
0.0017045746790245175,
-0.04030163958668709,
0.008595967665314674,
-0.015285619534552097,
0.006941098254173994,
-0.06642870604991913,
0.056885428726673126,
-0.038243286311626434,
-0.007075592875480652,
-0.008584273047745228,
-0.05922446772456169,
0.03583407774567604,
0.04156472161412239,
0.04060571640729904,
0.004891515243798494,
-0.04156472161412239,
-0.03676969185471535,
0.0655866488814354,
-0.021215083077549934,
-0.029050864279270172,
-0.002217701403424144,
0.07536383718252182,
-0.04523701220750809,
0.015683256089687347,
-0.03429030999541283,
-0.018478408455848694,
0.06357508152723312,
0.021215083077549934,
-0.044792596250772476,
-0.01748431660234928,
0.001414387603290379,
-0.003909118939191103,
0.007923494093120098,
-0.01889943517744541,
0.030992265790700912,
0.03775208815932274,
-0.023074619472026825,
0.027553878724575043,
-0.01940232887864113,
0.045845162123441696,
0.004616678226739168,
-0.021753061562776566,
-0.06315404921770096,
0.04631297290325165,
-0.034103188663721085,
0.015098496340215206,
-0.037097156047821045,
-0.05997295677661896,
0.007911799475550652,
-0.0017937504453584552,
0.031179388985037804,
-0.06614802032709122,
-0.007987817749381065,
0.003798014484345913,
-0.007748066447675228,
0.00949065014719963,
-0.021133216097950935,
-0.022899191826581955,
-0.05375111475586891,
-0.029167816042900085,
0.004230736754834652,
-0.011490528471767902,
0.02701590023934841,
-0.041705064475536346,
-0.0064148143865168095,
0.04809064045548439,
-0.006397271528840065,
-0.02558908611536026,
-0.04949406534433365,
0.01199926994740963,
0.04516684263944626,
-0.008081379346549511,
-0.031717367470264435,
0.001956021413207054,
0.011432052589952946,
0.011046111583709717,
0.003874033223837614,
0.048043858259916306,
0.010560761205852032,
-0.044418349862098694,
0.030313944444060326,
-0.04841810464859009,
0.022641897201538086,
0.0029895841144025326,
-0.00175866496283561,
-0.04958762601017952,
-0.016794299706816673,
-0.009595907293260098,
-0.0041517941281199455,
0.015507828444242477,
0.04020807892084122,
-0.050429679453372955,
-0.043716639280319214,
0.012408602051436901,
-0.01622123457491398,
0.01098763570189476,
-0.03096887469291687,
-0.040722668170928955,
0.002375586424022913,
-0.009157337248325348,
0.01896960660815239,
-0.040371812880039215,
-0.04395054280757904,
-0.022443078458309174,
-0.0009283060790039599,
0.022174088284373283,
0.024302614852786064,
0.008853262290358543,
-0.009321070276200771,
0.029308157041668892,
0.038594141602516174,
-0.018384845927357674,
-0.052909061312675476,
0.020256077870726585,
-0.02593994140625,
0.020489981397986412,
-0.030641410499811172,
-0.03382250294089317,
0.030781753361225128,
-0.0039266617968678474,
0.027553878724575043,
0.023577513173222542,
0.02727319486439228,
0.05244125425815582,
0.01948419399559498,
0.0018902358133345842,
-0.0005902418633922935,
-0.023156486451625824,
0.0034997870679944754,
-0.013917281292378902,
0.02337869442999363,
0.02937832847237587,
0.08032260090112686,
0.026314187794923782,
0.00930352695286274,
0.01810416206717491,
0.03323774412274361,
-0.0014385089743882418,
0.027600659057497978,
0.016805995255708694,
-0.055622346699237823,
0.011174758896231651,
0.000133489680592902,
0.010005239397287369,
-0.049540843814611435,
-0.03838362917304039,
-0.03209161385893822,
-0.05019577592611313,
-0.006321252789348364,
0.022641897201538086,
-0.020314553752541542,
0.043459344655275345,
-0.03183431923389435,
0.03555339202284813,
0.002640190301463008,
0.02336699888110161,
-0.007660352624952793,
-0.02233782224357128,
0.008326978422701359,
-0.006637022830545902,
-0.05524810031056404,
0.038874827325344086,
0.008566729724407196,
0.000901991908904165,
0.01872400753200054,
0.01605750247836113,
-0.039132121950387955,
0.019975392147898674,
0.0028068467509001493,
0.02937832847237587,
-0.03153024613857269,
-0.016618872061371803,
-0.035600174218416214,
0.03080514259636402,
0.027764393016695976,
-0.03917890414595604,
0.003757081227377057,
-0.057493578642606735,
0.0327933244407177,
0.010625084862112999,
0.03071158193051815,
0.025285011157393456,
0.06193774938583374,
0.01968301273882389,
-0.006215996108949184,
0.04888591542840004,
-0.007853323593735695,
-0.022758848965168,
0.002396052936092019,
0.011186453513801098,
-0.0009721630485728383,
-0.005271608941257,
-0.0080755315721035,
0.038991779088974,
-0.03800938278436661,
0.012665895745158195,
-0.025448743253946304,
-0.01557799894362688,
0.006438204552978277,
-0.018677225336432457,
-0.016700737178325653,
0.0005098374094814062,
0.033892672508955,
0.004914905410259962,
-0.010437961667776108,
-0.01668904349207878,
-0.027226412668824196,
0.02928476780653,
-0.021402206271886826,
0.01587037928402424,
-0.025729428976774216,
0.012502162717282772,
0.06184418871998787,
-0.03889821842312813,
-0.0002488883619662374,
-0.026173844933509827,
-0.052628375589847565,
0.012712677009403706,
0.0409097895026207,
0.012279954738914967,
-0.043810199946165085,
0.03553000092506409,
0.02734336443245411,
-0.014560517854988575,
-0.04497971758246422,
0.01728549785912037,
0.02893391251564026,
0.015273923985660076,
0.006461595185101032,
0.03555339202284813,
-0.007379667833447456,
-0.012630810029804707,
-0.005356399342417717,
0.014642383903265,
-0.0018873120425269008,
-0.017004813998937607,
0.012700981460511684,
0.00177474576048553,
-0.03335469588637352,
-0.004710239823907614,
-0.036044590175151825,
0.02030285820364952,
-0.03892160952091217,
0.02320326678454876,
-0.03026716411113739,
0.04935372248291969,
-0.027296584099531174,
0.003909118939191103,
0.04930694028735161,
0.03071158193051815,
-0.06025364249944687,
0.052815500646829605,
0.00386233814060688,
-0.017133459448814392,
-0.025635866448283195,
-0.026594873517751694,
0.018560273572802544,
0.03644222766160965,
-0.006853383965790272,
-0.013145399279892445,
0.03590424731373787,
-0.010332704521715641,
0.011894012801349163,
0.01975318416953087,
-0.004388622008264065,
0.032255347818136215,
0.012478772550821304,
0.02198696695268154,
-0.010133885778486729,
-0.0027498325798660517,
-0.055201318114995956,
0.017940428107976913,
0.004295060411095619,
-0.01486459281295538,
0.01195248868316412,
-0.028700007125735283,
0.04140098765492439,
0.007186697330325842,
0.0466170459985733,
-0.017706524580717087,
0.026711825281381607,
-0.02425583451986313,
-0.036582570523023605,
0.027530487626791,
0.023893283680081367,
-0.008707072585821152,
0.015940550714731216,
-0.06123603880405426,
0.035974420607089996,
0.03414996713399887,
-0.008595967665314674,
0.0008610587101429701,
0.039740271866321564,
0.04692112281918526,
0.020758969709277153,
-0.031015656888484955,
-0.012104526162147522,
-0.024232443422079086,
0.004786258563399315,
-0.012338430620729923,
-0.038079552352428436,
-0.04219626262784004,
0.00953158363699913,
-0.0053388564847409725,
-0.009215813130140305,
-0.01880587264895439,
-0.02912103570997715,
-0.024817204102873802,
0.062171656638383865,
0.006742279976606369,
0.10160785168409348,
0.051131390035152435,
-0.005145885515958071,
-0.042406775057315826,
-0.01967131718993187,
-0.01932046189904213,
-0.028278980404138565,
-0.03220856562256813,
-0.004315526690334082,
0.016478529199957848,
0.01686447113752365,
0.017776696011424065,
-0.04926016181707382,
-0.04030163958668709,
0.03302723169326782,
0.0393192432820797,
-0.012046050280332565,
0.03688664361834526,
0.019203510135412216,
-0.05936480686068535,
0.03466455638408661,
-0.03555339202284813,
0.058008164167404175,
0.0337289422750473,
-0.05613693594932556,
0.01887604407966137,
-0.028629837557673454,
0.0068475366570055485,
-0.06179741024971008,
0.03176414966583252,
-0.013975758105516434,
-0.015156972222030163,
-0.04509666934609413,
-0.02365937829017639,
0.03747140243649483,
0.026431139558553696,
0.022829020395874977,
0.0001722300221445039,
-0.002210391918197274,
-0.020595237612724304,
0.031717367470264435,
0.004771639592945576,
0.010133885778486729,
-0.02364768460392952,
0.031810928136110306,
0.0043242983520030975,
-0.026103675365447998,
0.02266528643667698,
0.005555217619985342,
-0.021133216097950935,
0.03335469588637352,
0.007806542329490185,
-0.004815496504306793,
0.01257233414798975,
-0.0393192432820797,
0.02736675553023815,
-0.034454043954610825,
-0.057914603501558304,
0.024372786283493042,
0.03562356159090996,
-0.03195127099752426,
0.02743692696094513,
-0.008303588256239891,
0.052628375589847565,
-0.046196017414331436,
-0.005558141507208347,
-0.07082609832286835,
-0.001524760969914496,
0.048932693898677826,
0.06006652116775513,
0.016607176512479782,
0.04607906565070152,
-0.009285984560847282,
0.03803277388215065,
-0.013426083140075207,
-0.02771761082112789,
0.014689164236187935,
-0.0218817088752985,
0.048230983316898346,
-0.014958154410123825,
-0.06399610638618469,
0.04748249053955078,
0.01984674483537674,
-0.013928976841270924,
0.0071691544726490974,
-0.025822989642620087,
-0.024934155866503716,
-0.0021372968330979347,
0.03461777791380882,
-0.030196992680430412,
0.022361211478710175,
-0.054499607533216476,
0.05534166097640991,
0.012268259190022945,
-0.021109826862812042,
-0.009859048761427402,
-0.010221600532531738,
0.0005504051223397255,
-0.03744801506400108,
-0.016092587262392044,
-0.03276993706822395,
-0.016560396179556847,
0.027156241238117218,
-0.018419932574033737,
-0.006531766150146723,
0.001141743385232985,
0.03176414966583252,
0.05941158905625343,
0.011870622634887695,
0.02030285820364952,
0.018338065594434738,
0.026781996712088585,
0.020337942987680435,
-0.0020261923782527447,
0.0035114821512252092,
-0.0011563623556867242,
0.0027439850382506847,
-0.038781266659498215,
-0.022045442834496498,
-0.04137760028243065,
-0.0031167694833129644,
-0.011929098516702652,
0.0089117381721735,
-0.01557799894362688,
0.038430411368608475,
0.006052263081073761,
0.020010478794574738,
0.017542792484164238,
0.009905830025672913,
-0.01486459281295538,
-0.04341256245970726,
-0.04121386632323265,
-0.028466103598475456,
0.010554913431406021,
-0.004163489211350679,
-0.01748431660234928,
0.026501310989260674,
-0.005341780371963978,
-0.028887130320072174,
-0.04745909944176674,
-0.00816324632614851,
-0.03583407774567604,
-0.03450082615017891,
-0.01596393994987011,
-0.012654201127588749,
0.006408966612070799,
-0.017086679115891457,
-0.01053737010806799,
0.016572091728448868,
0.004923677071928978,
0.012993360869586468,
-0.006713041570037603,
-0.017683135345578194,
0.03536627069115639,
-0.02136712148785591,
0.03602119907736778,
-0.020220991224050522,
0.013355912640690804,
-0.041611503809690475,
-0.03761174529790878,
0.0001579764939378947,
-0.0006637023179791868,
-0.028629837557673454,
-0.008057989180088043,
-0.049727968871593475,
-0.024489738047122955,
-0.037564966827631,
0.011233234778046608,
0.017765000462532043,
-0.011315100826323032,
0.011853080242872238,
-0.039740271866321564,
0.04612584784626961,
-0.005122495349496603,
-0.0026489614974707365,
-0.012700981460511684,
-0.01018651481717825,
0.017425840720534325,
-0.003216178622096777,
-0.005455808248370886,
-0.00547335110604763,
-0.022454774007201195,
0.016455138102173805,
-0.01159578561782837,
-0.044254615902900696,
-0.048558447510004044,
0.022267650812864304,
-0.017706524580717087,
0.017098374664783478,
-0.04708485305309296,
-0.015507828444242477,
-0.0031489310786128044,
0.02444295771420002,
0.05178632214665413,
0.00721008749678731,
0.013040142133831978,
0.008227569051086903,
-0.042476948350667953,
0.030734971165657043,
0.03396284580230713,
-0.018150942400097847,
-0.01319217961281538,
-0.00637388089671731,
0.00816324632614851,
-0.005110800266265869,
-0.026594873517751694,
-0.043365780264139175,
-0.023624293506145477,
0.038874827325344086,
-0.0066136326640844345,
-0.017870256677269936,
-0.017402449622750282,
0.011262472718954086,
0.05234768986701965,
0.03485168144106865,
-0.025074496865272522,
-0.007993665523827076,
-0.013122008182108402,
0.021215083077549934,
0.014712555333971977,
0.01562478020787239,
0.025261620059609413,
-0.003958823624998331,
-0.023320218548178673,
0.02418566308915615,
0.00873631052672863,
-0.002549552358686924,
0.020595237612724304,
-0.02390497736632824,
-0.0219635758548975,
-0.007151611614972353,
0.025916552171111107,
-0.01540257129818201,
-0.0072802589274942875,
-0.04397393390536308,
0.004897363018244505,
0.04102674126625061,
-0.004929524380713701,
-0.02788134478032589,
0.02664165385067463,
0.007876713760197163,
-0.000871292024385184,
0.013274045661091805,
0.0065025282092392445,
0.02399853989481926,
0.0021811537444591522,
0.017437534406781197,
0.03726089000701904,
-0.01482950709760189,
-0.03494524210691452,
-0.031460072845220566,
0.006607784889638424,
-0.018419932574033737,
-0.019542669877409935,
-0.031039046123623848,
0.025308402255177498,
0.0026065665297210217,
0.01906316727399826,
-0.007865018211305141,
0.014700859785079956,
0.011449595913290977,
0.0063797286711633205,
0.05304940417408943,
-0.04757605120539665,
0.036301884800195694,
0.01323896087706089,
-0.002264481969177723,
-0.01639666222035885,
0.003625510260462761,
0.01825619861483574,
-0.00047767561045475304,
0.0060931965708732605,
-0.0005142230656929314,
0.052909061312675476,
-0.01098178792744875,
0.016455138102173805,
-0.015496132895350456,
-0.001455320743843913,
-0.005318389739841223,
-0.005239447113126516,
-0.033752333372831345,
-0.03803277388215065,
0.015192057937383652,
0.007876713760197163,
0.017776696011424065,
-0.019636232405900955,
-0.07583164423704147,
0.01639666222035885,
0.008666139096021652,
0.006011330056935549,
-0.0074790772050619125,
0.02313309535384178,
0.004938296042382717,
0.02056015282869339,
-0.01792873442173004,
-0.009245051071047783,
-0.03298044949769974,
0.004689773079007864,
-0.026056893169879913,
0.0000779375113779679,
-0.012525553815066814,
-0.04741232097148895,
-0.008607663214206696,
0.035951029509305954,
-0.0037629290018230677,
0.020443201065063477,
-0.025004325434565544,
0.018150942400097847,
-0.02038472518324852,
-0.012010964564979076,
-0.018209418281912804,
0.025074496865272522,
0.0034062254708260298,
-0.010882378555834293,
-0.02232612669467926,
-0.0026474997866898775,
-0.026875557377934456,
-0.028629837557673454,
-0.010011086240410805,
-0.01419796608388424,
0.0015510752564296126,
0.007765609305351973,
0.019367242231965065,
-0.012303344905376434,
0.03847718983888626,
-0.005613693501800299,
0.0065025282092392445,
0.05435926467180252,
0.026805385947227478,
-0.018735701218247414,
0.04640653356909752,
-0.005444113165140152,
-0.009952610358595848,
0.0187006164342165,
-0.0097479447722435,
-0.014233051799237728,
-0.03452421352267265,
-0.03115599788725376,
0.02268867753446102,
0.00979472603648901,
-0.040418591350317,
-0.02012743055820465,
-0.013566426001489162,
0.0219635758548975,
-0.0010503747034817934,
-0.032957058399915695,
0.02453651838004589,
-0.007683742791414261,
0.025706037878990173,
0.032957058399915695,
0.008818176575005054,
-0.01522714365273714,
-0.0037278432864695787,
0.0035845772363245487,
0.007818237878382206,
-0.00597624434158206,
-0.003093379084020853,
-0.008712920360267162,
-0.059598714113235474,
-0.00006363830470945686,
0.0014304685173556209,
-0.04331900179386139,
-0.007824085652828217,
-0.02198696695268154,
-0.008274350315332413,
-0.0038214048836380243,
-0.01571834087371826,
-0.010356094688177109,
0.005031857639551163,
0.011630871333181858,
0.025706037878990173,
-0.01416288036853075,
0.012198087759315968,
-0.003216178622096777,
-0.01622123457491398,
0.009777182713150978,
-0.021144911646842957,
0.003964670933783054,
-0.012244869023561478,
-0.037237498909235,
-0.002233782084658742,
0.0031430835369974375,
0.02816202864050865,
0.016724128276109695,
-0.014361699111759663,
0.005824206862598658,
0.008420540019869804,
-0.015133582055568695,
-0.014654078520834446,
0.015461047179996967,
0.026665043085813522,
-0.011911556124687195,
-0.026454530656337738,
0.0065259188413619995,
0.016969727352261543,
-0.03545983135700226,
0.02057184837758541,
0.0075434003956615925,
0.005058171693235636,
0.028887130320072174,
-0.05024255812168121,
-0.021133216097950935,
-0.022630201652646065,
0.010870683938264847,
-0.05071036517620087,
0.013858805410563946,
-0.02867661789059639,
0.016361577436327934,
0.05216056853532791,
-0.01569495163857937,
0.017004813998937607,
-0.046196017414331436,
0.007011269219219685,
-0.012853018939495087,
-0.029705794528126717,
-0.01274776179343462,
-0.036138150840997696,
0.00403776578605175,
-0.004631297197192907,
0.029331548139452934,
-0.04128403589129448,
0.035342879593372345,
-0.011654261499643326,
0.03653578832745552,
0.004701468162238598,
0.016232930123806,
-0.010847292840480804,
-0.025893161073327065,
-0.008566729724407196,
0.014677469618618488,
0.006227691192179918,
0.018665531650185585,
-0.014700859785079956,
0.009432174265384674,
0.023156486451625824,
-0.041424378752708435,
0.02258342131972313,
0.006870926823467016,
-0.013110313564538956,
-0.0018551502143964171,
0.009461412206292152,
0.023437170311808586,
0.00608734879642725,
-0.0008552111103199422,
-0.01363659743219614,
0.00017643297906033695,
-0.005999634973704815,
-0.013051837682723999,
-0.007069745101034641,
-0.030571239069104195,
0.019028082489967346,
-0.029237987473607063,
-0.04004434496164322,
0.015390876680612564,
-0.019039776176214218,
-0.018197722733020782,
-0.0032951210159808397,
0.034547604620456696,
0.011671803891658783,
0.017963819205760956,
-0.02241968736052513,
0.03602119907736778,
0.00788840837776661,
-0.041167084127664566,
-0.01544935256242752,
-0.037985991686582565,
-0.025893161073327065,
0.036652740091085434,
-0.016092587262392044,
0.009397088550031185,
0.0169463362544775,
0.006385576445609331,
-0.02867661789059639,
0.012806238606572151,
0.03417335823178291,
-0.006344642955809832,
0.019542669877409935,
-0.02320326678454876,
0.009917525574564934,
-0.011016873642802238,
-0.024934155866503716,
-0.011584090068936348,
-0.0030670647975057364,
0.018221113830804825,
0.007081440184265375,
-0.013180484063923359,
-0.010052019730210304,
-0.001707498449832201,
0.029846137389540672,
-0.019273681566119194,
-0.02736675553023815,
-0.01606919802725315,
0.018396541476249695,
0.004268745891749859,
0.0011015411000698805,
-0.0089117381721735,
-0.04624279960989952,
0.0013149784645065665,
-0.009940915741026402,
-0.002533471444621682,
0.050429679453372955,
-0.01755448803305626,
-0.016455138102173805,
-0.02727319486439228,
-0.010870683938264847,
-0.013858805410563946,
-0.000207041492103599,
-0.011677651666104794,
-0.00003239020588807762,
-0.021577633917331696,
0.031039046123623848,
-0.036325275897979736,
0.010239142924547195,
0.009876592084765434,
-0.012408602051436901,
0.011081197299063206,
0.02804507687687874,
-0.04851166903972626,
0.018127551302313805,
0.008759700693190098,
0.06497850269079208,
0.013706767931580544,
-0.01799890398979187,
-0.015285619534552097,
0.007069745101034641,
0.009952610358595848,
0.031272951513528824,
0.029705794528126717,
0.013893891125917435,
0.027413535863161087,
-0.0032395690213888884,
0.008654444478452206,
-0.0097479447722435,
-0.03450082615017891,
-0.009736249223351479,
0.032325517386198044,
0.018513493239879608,
0.03192787989974022,
0.00912809930741787,
0.019905220717191696,
-0.005873911548405886,
-0.025706037878990173,
0.0007667661993764341,
0.007028812076896429,
0.04748249053955078,
0.017963819205760956,
-0.046640437096357346,
0.013449474237859249,
0.008309436030685902,
-0.035085584968328476,
0.01518036238849163,
0.00016537736519239843,
0.019297070801258087,
0.040816228836774826,
0.025285011157393456,
0.032512642443180084,
-0.02867661789059639,
-0.03730767220258713,
-0.029542062431573868,
0.018677225336432457,
0.006531766150146723,
0.05725967511534691,
-0.04757605120539665,
-0.034196749329566956,
-0.020981179550290108,
-0.045658040791749954,
-0.014958154410123825,
0.031998053193092346,
0.021858319640159607,
-0.030875314027071,
0.027951516211032867,
-0.04308509826660156,
0.05543522164225578,
0.001279161893762648,
-0.01650192029774189,
0.03288688883185387,
-0.00012755072384607047,
-0.004713163245469332,
0.00013952002336736768,
0.021753061562776566,
-0.01701650768518448,
0.01174197532236576,
0.013928976841270924,
0.058288849890232086,
0.021285254508256912,
-0.03990400582551956,
-0.005707255098968744,
-0.03398623690009117,
-0.0017221174202859402,
-0.019987087696790695,
-0.003546567866578698,
-0.007198392413556576,
0.048932693898677826,
0.03567034378647804,
0.048745572566986084,
-0.04411427304148674,
-0.034711338579654694,
0.001539380056783557,
-0.03662934899330139,
-0.03167058899998665,
-0.03174075856804848,
0.007484924513846636,
0.05777426064014435,
-0.006262776907533407,
-0.034711338579654694,
0.01622123457491398,
0.032161787152290344,
-0.03555339202284813,
-0.024559909477829933,
0.05955193191766739,
0.0006249619764275849,
0.04832454398274422,
-0.024372786283493042,
0.03679308295249939,
0.03258281201124191,
-0.008636901155114174,
-0.020314553752541542,
-0.014186271466314793,
-0.04069927707314491,
0.003748309798538685,
-0.02542535401880741,
-0.02638435922563076,
0.01098763570189476,
0.00389449973590672,
0.013355912640690804,
0.02495754510164261,
0.015507828444242477,
0.007227630354464054,
-0.01336760725826025,
0.020852532237768173,
-0.016256321221590042,
0.031904492527246475,
0.029401719570159912,
0.011630871333181858,
0.014735945500433445,
-0.00467807799577713,
-0.009204118512570858,
-0.040792837738990784,
0.014724249951541424,
-0.003488091751933098,
0.05679186433553696,
0.03688664361834526,
-0.04647670313715935,
-0.00259048561565578,
-0.015028324909508228,
0.023764636367559433,
0.036676131188869476,
-0.010163124650716782,
-0.002241091802716255,
-0.00630955770611763,
-0.01014558132737875,
-0.008566729724407196,
-0.000983858248218894,
0.006829993799328804,
0.01518036238849163,
0.03784564882516861,
-0.01018651481717825,
-0.020419809967279434,
0.041868798434734344,
0.01177706103771925,
-0.00895851943641901,
-0.01438508927822113,
-0.021823232993483543,
0.005648779217153788,
0.024115491658449173,
0.02495754510164261,
0.0010869221296161413,
-0.04067588597536087,
0.01632649265229702,
0.010280076414346695,
-0.014396784827113152,
-0.016256321221590042,
-0.003838947741314769,
0.018338065594434738,
0.03122616931796074,
-0.008572577498853207,
0.0056370836682617664,
-0.014233051799237728,
-0.017671439796686172,
0.01994030736386776,
-0.006578546948730946,
0.015355790965259075,
0.002966193715110421,
0.020501676946878433,
0.018642140552401543,
0.02762405015528202,
-0.008239264599978924,
-0.03433709219098091,
0.011443748138844967,
0.0007506852853111923,
-0.015835294499993324,
0.018478408455848694,
-0.01624462567269802,
-0.018022295087575912,
-0.004888591356575489,
-0.01540257129818201,
-0.03997417539358139,
-0.018653836101293564,
0.01597563549876213,
0.017612963914871216,
0.009718706831336021,
0.024209052324295044,
0.007683742791414261,
-0.046804171055555344,
-0.017952123656868935,
-0.0007843089988455176,
-0.004596211481839418,
-0.029074253514409065,
0.030126821249723434,
0.002002802211791277,
-0.02117999829351902,
0.027296584099531174,
-0.0005686788354068995,
0.0021036730613559484,
-0.012092831544578075,
0.009028689935803413,
0.011046111583709717,
0.0041868798434734344,
-0.004166413098573685,
0.006625327747315168,
0.019203510135412216,
-0.005666321609169245,
-0.017601268365979195,
0.010420418344438076,
-0.018501797690987587,
0.017425840720534325,
0.029542062431573868,
-0.0040582325309515,
-0.03889821842312813,
-0.0012024121824651957,
0.04783334583044052,
0.0010978863574564457,
-0.003344825701788068,
-0.01923859491944313,
-0.003224950050935149,
0.005882682744413614,
-0.01809246651828289,
-0.002350734081119299,
0.027928125113248825,
-0.021051350980997086,
0.005245294887572527,
0.021226778626441956,
-0.012782847508788109,
0.04189218580722809,
0.029518671333789825,
0.004952915012836456,
0.012046050280332565,
0.002584638074040413,
0.007707133423537016,
-0.009052081033587456,
0.062265217304229736,
-0.03784564882516861,
-0.02144898660480976,
0.018688920885324478,
0.04006773605942726,
-0.011788756586611271,
0.027811173349618912,
0.005552293732762337,
0.01686447113752365,
0.011116283014416695,
-0.0024238291662186384,
0.026758605614304543,
0.01561308465898037,
-0.015145277604460716,
0.02495754510164261,
-0.0008859109948389232,
0.004528963938355446,
0.005502589046955109,
-0.027203023433685303,
-0.004730706103146076,
0.014104404486715794,
-0.001309861778281629,
-0.01933215744793415,
0.019624536857008934,
-0.02965901419520378,
-0.008525797165930271,
0.040278252214193344,
0.0068475366570055485,
-0.014081014320254326,
0.02099287509918213,
0.002881403546780348,
-0.00816324632614851,
-0.042009137570858,
-0.02788134478032589,
-0.012736067175865173,
-0.040722668170928955,
-0.022571725770831108,
-0.003985137678682804,
0.017145154997706413,
-0.010087105445563793,
0.005385637283325195,
-0.005546445958316326,
0.023951759561896324,
0.01791703887283802,
-0.04411427304148674,
-0.002798075322061777,
-0.01116306334733963,
0.02727319486439228,
-0.0008720229379832745,
0.000381190242478624,
-0.03814972564578056,
-0.0005968203768134117,
0.012759457342326641,
0.004631297197192907,
0.024326004087924957,
-0.0007291223155334592,
0.0030758362263441086,
0.062265217304229736,
0.011244929395616055,
0.013355912640690804,
-0.006777365226298571,
0.017133459448814392,
-0.03627849370241165,
0.029752574861049652,
-0.00913394708186388,
-0.009239204227924347,
-0.005777426064014435,
-0.008876652456820011,
0.006017177831381559,
0.005031857639551163,
0.01133264321833849,
-0.009707011282444,
-0.022712068632245064,
0.002188463229686022,
0.009584211744368076,
0.019916916266083717,
0.00891758594661951,
-0.014841201715171337,
-0.03431370109319687,
0.00380386202596128,
0.02189340442419052,
0.01940232887864113,
0.02294597215950489,
0.025214839726686478,
-0.038944996893405914,
0.016560396179556847,
-0.009695316664874554,
-0.004604983143508434,
-0.05075714364647865,
-0.0042131938971579075,
0.0030612172558903694,
0.013262351043522358,
0.036395445466041565,
0.017952123656868935,
-0.010660169646143913,
0.006251081358641386,
-0.032348908483982086,
-0.02153085358440876,
0.01478272583335638,
0.0032337212469428778,
0.015344095416367054,
0.016911251470446587,
-0.017846867442131042,
0.006280319765210152,
-0.004069927614182234,
-0.02577620930969715,
-0.027741001918911934,
0.009034537710249424,
0.031109217554330826,
-0.008484863676130772,
-0.02823220007121563,
-0.010338552296161652,
0.021659500896930695,
0.0037278432864695787,
-0.0025875617284327745,
0.010566608048975468,
-0.014735945500433445,
-0.005107876379042864,
-0.025542305782437325,
-0.001100810244679451,
0.01719193533062935,
-0.012548943981528282,
0.014221357181668282,
0.0031781692523509264,
-0.0003822866710834205,
-0.013005056418478489,
0.010005239397287369,
0.027460318058729172,
-0.028115248307585716,
0.01010464783757925,
-0.002242553513497114,
0.023519037291407585,
-0.008057989180088043,
-0.05309618264436722,
-0.00004292045196052641,
0.006765670143067837,
0.007794847246259451,
-0.018583664670586586,
0.051037829369306564,
0.02533179149031639,
-0.0074206008575856686,
0.03302723169326782,
-0.022817324846982956,
0.014548822306096554,
-0.006362185813486576,
0.03167058899998665,
0.00044076264020986855,
-0.05337686836719513,
-0.012502162717282772,
0.028559666126966476,
-0.020010478794574738,
0.02841932326555252,
-0.0013873424613848329,
0.001982335466891527,
0.03337808698415756,
0.001992568839341402,
-0.019414022564888,
-0.039670102298259735,
0.007642809767276049,
0.012700981460511684,
-0.03017360158264637,
0.009046233259141445,
-0.019028082489967346,
0.010695255361497402,
0.024302614852786064,
-0.010075409896671772,
-0.010490589775145054,
0.04413766413927078,
0.005642931442707777,
0.009373698383569717,
0.03672290965914726,
0.009905830025672913,
0.017273802310228348,
-0.037354450672864914,
-0.042009137570858,
-0.024372786283493042,
-0.026337578892707825,
0.04334239289164543,
-0.03344825655221939,
0.019718097522854805,
0.0000562831228307914,
0.000036296220059739426,
0.02893391251564026,
0.0037600051146000624,
-0.04509666934609413,
-0.015145277604460716,
-0.004423707257956266,
-0.014303223229944706,
-0.008824024349451065,
-0.002559785731136799,
-0.023320218548178673,
0.02364768460392952,
-0.003420844441279769,
0.003429615870118141,
0.02638435922563076,
-0.008011208847165108,
0.01860705390572548,
0.0038272524252533913,
0.01274776179343462,
0.0050172386690974236,
0.03567034378647804,
-0.022466469556093216,
-0.014724249951541424,
0.032512642443180084,
-0.01853688433766365,
-0.022747153416275978,
-0.018677225336432457,
0.030664799734950066,
-0.03209161385893822,
0.006210148334503174,
-0.0007587257423438132,
-0.016548700630664825,
-0.002305415226146579,
0.0046722302213311195,
0.023519037291407585,
0.02657148241996765,
0.00494414335116744,
0.027226412668824196,
-0.017425840720534325,
0.014303223229944706,
-0.03045428730547428,
-0.03134312108159065,
0.011326796375215054,
-0.0019399403827264905,
0.007163306698203087,
0.0031986357644200325,
-0.011987574398517609,
-0.008666139096021652,
-0.005397332366555929,
-0.012888104654848576,
0.014233051799237728,
0.003049521939828992,
-0.03178754076361656,
0.01642005331814289,
-0.005417799111455679,
-0.000007692103281442542,
0.0014165804022923112,
-0.015858683735132217,
-0.005663398187607527,
0.013227265328168869,
-0.032161787152290344,
-0.019636232405900955,
-0.020408114418387413,
0.03000986948609352,
0.0058973017148673534,
0.026781996712088585,
0.011864774860441685,
-0.005028933752328157,
-0.05370433256030083,
-0.004663459025323391,
-0.014583908021450043,
0.004011451732367277,
0.013741853646934032,
-0.03482829034328461,
0.02073558047413826,
0.015250533819198608,
-0.02460668981075287,
-0.028442714363336563,
-0.049447283148765564,
-0.022349517792463303,
-0.027647439390420914,
0.023776330053806305,
-0.026688434183597565,
0.009297680109739304,
-0.01481781154870987,
0.02771761082112789,
-0.03106243722140789,
-0.018992995843291283,
0.007981969974935055,
0.019180119037628174,
0.024747032672166824,
0.016548700630664825,
-0.023694464936852455,
0.02998647838830948,
-0.020326249301433563,
0.010899921879172325,
-0.031039046123623848,
-0.0015262229135259986,
0.019554365426301956,
0.00847316812723875,
-0.027600659057497978,
0.032465860247612,
0.026852166280150414,
-0.0043856981210410595,
-0.023238351568579674,
0.004990924149751663,
-0.033752333372831345,
0.012969970703125,
-0.04374002665281296,
-0.006449900101870298,
-0.002299567684531212,
0.036138150840997696,
0.003029055427759886,
-0.007157459389418364,
-0.03036072477698326,
-0.00034994215820915997,
-0.017098374664783478,
-0.0547335110604763,
-0.029354939237236977,
-0.021191691979765892,
-0.019215205684304237,
-0.005204361863434315,
0.03733106330037117,
0.016607176512479782,
0.017765000462532043,
0.010625084862112999,
-0.01139112003147602,
0.002906255889683962,
-0.025706037878990173,
-0.02372954972088337,
0.026267407462000847,
-0.02664165385067463,
-0.0069001647643744946,
0.03160041570663452,
0.037985991686582565,
-0.0043856981210410595,
0.012151307426393032,
0.008841567672789097,
-0.009116404689848423,
0.008671986870467663,
-0.043108489364385605,
0.027132852002978325,
-0.02364768460392952,
0.0065902420319616795,
0.09777183085680008,
0.004067004192620516,
0.003441310953348875,
0.01948419399559498,
0.020852532237768173,
-0.017437534406781197,
0.010174819268286228,
-0.025308402255177498,
0.006338795647025108,
0.031460072845220566,
0.010800512507557869,
0.027413535863161087,
0.02858305536210537,
0.06371542066335678,
0.010040325112640858,
0.008221722207963467,
0.018817568197846413,
-0.001961868954822421,
0.0009100323659367859,
0.001570079941302538,
-0.01570664718747139,
0.01239690650254488,
-0.03096887469291687,
0.0014195042895153165,
-0.004859353415668011,
-0.016700737178325653,
-0.03248925134539604,
0.00059864780632779,
0.004444174002856016,
-0.020700493827462196,
0.027998296543955803,
-0.012373516336083412,
0.043459344655275345,
-0.002915027318522334,
0.009344460442662239,
-0.030337335541844368,
-0.017004813998937607,
-0.006713041570037603,
0.019121643155813217,
0.00710483081638813,
0.01852518878877163,
0.000513492152094841,
-0.022291041910648346,
0.01112212985754013,
-0.021215083077549934,
0.006794908083975315,
-0.007116525899618864,
-0.004871048498898745,
0.004537735600024462,
-0.03583407774567604,
-0.014759335666894913,
0.013496254570782185,
0.006432357244193554,
-0.011092891916632652,
-0.017823476344347,
-0.011929098516702652,
0.023940064013004303,
0.007970275357365608,
-0.006508375983685255,
-0.017262106761336327,
0.0023463484831154346,
0.012759457342326641,
0.018314674496650696,
0.016993118450045586,
-0.006929402705281973
] | 2025-01-17 | 1 | 39820375 | [
"likely future indications",
"ongoing trials",
"follicular lymphoma",
"T-cell engagers",
"antigen receptor T-cell therapy",
"immune effector cell-related toxicities",
"particular emphasis",
"large B-cell lymphoma",
"indications",
"CD20-targeting T-cell engagers",
"care",
"patients",
"the registrational clinical trials",
"alternatives",
"mosunetuzumab",
"our current treatment paradigm",
"epcoritamab",
"the treatment options",
"glofitamab",
"relapsed or refractory disease",
"a detailed overview",
"The rapid emergence",
"their use",
"a review",
"our management",
"We",
"we"
] | [] | 0 | null | [
"Lutfi",
"Ahmed",
"Hoffmann",
"Tun",
"McGuirk"
] | [
"Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.",
"Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.",
"Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.",
"Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas.",
"Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, Kansas."
] | [
"39820375"
] | [] | 5.959595 | 6.407292 |
39820359 | 20 | Phase I study of CD19 CAR T-cell therapy harboring a fully human scFv in CAR-naïve adult B-ALL patients. | CD19-directed chimeric antigen receptor-engineered (CD19 CAR) T-cell therapy elicits high response rates but fails to induce durable responses in most adults with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). In a previous clinical trial (NCT01865617), we observed anti-CAR immune responses associated with impaired in vivo CAR T-cell expansion after second infusions. Because these CD8+ T-cell responses were predominantly directed at peptides derived from the murine single chain variable fragment (scFv) in the CAR, we conducted a clinical trial investigating the safety and efficacy of CD19 CAR T-cells engineered with a CAR incorporating a fully human scFv (JCAR021) in adults with R/R B-ALL (NCT03103971). Twenty-three patients received lymphodepletion chemotherapy and JCAR021 infusion. Nineteen patients developed CRS (any grade, 83%; grade 2, 61%) and 12 developed neurotoxicity (52%; grade ≥3, 35%). The overall response and CR/CRi rates were 82% and 64%, respectively. We observed MRD-negative marrow responses in 82% of those with marrow disease and extramedullary responses by PET-CT in 79% (CR, 50%) of those with measurable FDG-avid disease. The median duration of remission (DOR) was 10 months with a 4-year DOR probability of 29%. Four patients underwent allo-HCT while in CR/CRi after JCAR021. Durable remissions were observed in patients with low marrow disease burden. In contrast, the DOR was limited in those with high marrow burden, highlighting a remaining critical need to identify new strategies to prolong remissions. We observed similar outcomes in CAR-naïve adult B-ALL patients receiving CD19 CAR T-cells expressing a fully human or murine scFv-containing CAR. | [
0.005445249378681183,
0.03553156554698944,
0.04558813199400902,
0.03627283498644829,
-0.024387797340750694,
-0.03318420797586441,
-0.009692111052572727,
0.011829441413283348,
0.011934454552829266,
-0.00003329926039441489,
-0.01624617725610733,
-0.029675526544451714,
-0.04899797588586807,
0.013355222530663013,
0.031133359298110008,
-0.024486634880304337,
0.06216788291931152,
-0.021583324298262596,
0.010464267805218697,
0.014813054352998734,
0.02348591946065426,
0.0027473336085677147,
-0.0018593533895909786,
-0.01845763437449932,
-0.0006879916181787848,
-0.044920988380908966,
0.019643666222691536,
0.007486831396818161,
-0.0033944009337574244,
-0.038966115564107895,
0.013503476977348328,
-0.011922099627554417,
-0.036865849047899246,
0.0013327425112947822,
-0.007641262840479612,
0.03723648563027382,
0.051197078078985214,
-0.02084205485880375,
-0.019470704719424248,
-0.03600103408098221,
0.013515830971300602,
-0.005673807580024004,
0.041881781071424484,
0.06093243137001991,
-0.06028999760746956,
-0.034073732793331146,
-0.008277520537376404,
-0.04195590689778328,
0.012947523966431618,
0.00017827168630901724,
-0.034098442643880844,
0.01242863480001688,
-0.0312321949750185,
0.051592424511909485,
-0.054952848702669144,
0.05371739715337753,
0.001530414680019021,
0.005751023069024086,
-0.005936340894550085,
-0.018371153622865677,
0.03792833909392357,
-0.022954674437642097,
0.023658882826566696,
-0.02414070814847946,
-0.03357955068349838,
-0.00610621552914381,
-0.05010988190770149,
-0.003876226721331477,
0.03558098152279854,
0.02957669086754322,
-0.01956954039633274,
0.0038638722617179155,
0.028810711577534676,
-0.0033944009337574244,
0.041585274040699005,
0.03985564038157463,
0.027847060933709145,
0.00004565376730170101,
-0.01570257917046547,
-0.0024477369152009487,
-0.0034036668948829174,
0.016567394137382507,
-0.011891213245689869,
-0.06503412872552872,
0.00144161656498909,
-0.017395146191120148,
0.02611742913722992,
-0.025944465771317482,
0.016036150977015495,
0.02178099751472473,
-0.012076531536877155,
0.007585667539387941,
-0.06221729889512062,
0.04835554212331772,
0.014887182042002678,
-0.015183690004050732,
0.006479939445853233,
-0.06434227526187897,
0.04615643993020058,
0.023152347654104233,
0.049788665026426315,
0.006161810830235481,
0.03278886154294014,
-0.020372582599520683,
0.009778592735528946,
0.010161582380533218,
-0.06206904724240303,
0.008944663219153881,
0.040498074144124985,
-0.027995314449071884,
0.051197078078985214,
-0.002060114173218608,
0.006109303794801235,
0.03681643307209015,
-0.013083423487842083,
-0.05322321876883507,
-0.03775537386536598,
-0.03681643307209015,
-0.02693282626569271,
0.013009296730160713,
-0.017419856041669846,
0.04652707651257515,
0.01932244934141636,
-0.02710578963160515,
0.002907942282035947,
-0.008123088628053665,
0.08233043551445007,
-0.025722084566950798,
-0.02750113420188427,
-0.0513453334569931,
0.017531046643853188,
0.02903309278190136,
0.0018717078492045403,
-0.023807136341929436,
-0.08069964498281479,
0.010254241526126862,
-0.019767211750149727,
-0.021200334653258324,
-0.03397489711642265,
-0.013206969015300274,
0.028365949168801308,
-0.015196043998003006,
-0.023238828405737877,
0.0014833130408078432,
-0.04939332231879234,
-0.038126010447740555,
0.008808763697743416,
-0.015764351934194565,
0.004327166359871626,
0.017716363072395325,
-0.04274659603834152,
0.059252217411994934,
0.016690939664840698,
0.01028512790799141,
0.017283955588936806,
-0.062316134572029114,
-0.02210221439599991,
0.03483971208333969,
-0.046749457716941833,
-0.04712009057402611,
-0.014874827116727829,
0.003724884008988738,
-0.04329019412398338,
-0.041437018662691116,
0.01902594231069088,
-0.010383963584899902,
-0.0036260478664189577,
0.010359254665672779,
-0.07936535775661469,
0.015109562315046787,
-0.015393716283142567,
-0.005204336252063513,
-0.09152219444513321,
-0.05337147414684296,
-0.04677416384220123,
0.00753007223829627,
0.03002145327627659,
-0.008450482971966267,
-0.0037928337696939707,
-0.009469729848206043,
0.024350734427571297,
0.004707067273557186,
0.025870338082313538,
-0.03461733087897301,
-0.03543272614479065,
0.02390597201883793,
-0.023992454633116722,
0.013021650724112988,
-0.054508086293935776,
-0.013589958660304546,
0.010464267805218697,
-0.0025975352618843317,
0.06602248549461365,
0.009463552385568619,
-0.0004764207114931196,
-0.021360943093895912,
0.03654463216662407,
0.022287530824542046,
-0.08430715650320053,
-0.010742244310677052,
0.020718509331345558,
-0.026364518329501152,
-0.044945698231458664,
-0.012583065778017044,
-0.030095580965280533,
0.001734263962134719,
-0.015245462767779827,
0.016073213890194893,
-0.02834124118089676,
-0.05391507223248482,
0.0695311650633812,
0.007554781157523394,
-0.03231939300894737,
0.03733532130718231,
-0.0284647848457098,
-0.02498081512749195,
0.005296994931995869,
0.03768124803900719,
0.015183690004050732,
-0.014677154831588268,
0.0007802643813192844,
-0.007208855357021093,
-0.024832559749484062,
0.013071068562567234,
-0.007931593805551529,
-0.003005234058946371,
0.02873658388853073,
-0.022299885749816895,
-0.01681448519229889,
-0.04012744128704071,
0.007227386813610792,
0.025870338082313538,
0.021360943093895912,
-0.02470901422202587,
-0.0031967288814485073,
-0.007295336574316025,
0.01571493409574032,
0.013491122052073479,
0.06834513694047928,
-0.010068923234939575,
-0.025895047932863235,
0.03096039593219757,
0.025178486481308937,
-0.017271600663661957,
0.001575971837155521,
-0.01960660330951214,
-0.008580205962061882,
-0.06414460390806198,
0.034666746854782104,
-0.0061525446362793446,
-0.0001382160553475842,
0.008067493326961994,
-0.013268740847706795,
-0.02680928073823452,
0.007177968975156546,
-0.0009636515751481056,
0.03503738343715668,
-0.018222898244857788,
-0.019940175116062164,
-0.02473372407257557,
-0.0018439101986587048,
-0.014689509756863117,
-0.0138864666223526,
-0.05475517734885216,
-0.052729036659002304,
0.02873658388853073,
-0.0027689540293067694,
0.008135443553328514,
0.018445279449224472,
0.009506793692708015,
-0.006603484507650137,
0.014417710714042187,
0.02900838293135166,
-0.025203196331858635,
-0.03780479356646538,
0.016826840117573738,
0.02456076070666313,
0.023572400212287903,
-0.02026139199733734,
0.02459782548248768,
0.012447166256606579,
0.022584039717912674,
-0.024919042363762856,
-0.03661876171827316,
-0.0028399925213307142,
-0.00930294394493103,
0.0159743782132864,
-0.024906687438488007,
0.010532218031585217,
-0.00014265596109908074,
0.009766237810254097,
-0.019137132912874222,
-0.004182000644505024,
-0.025302032008767128,
-0.024832559749484062,
-0.0013566793641075492,
0.014108847826719284,
-0.030046163126826286,
-0.02526496723294258,
0.05668248236179352,
-0.007072955369949341,
0.04635411128401756,
0.0028801446314901114,
-0.013454059138894081,
0.0016138075152412057,
0.05356914550065994,
0.007505363319069147,
0.020076075568795204,
-0.00352103472687304,
0.04833083227276802,
-0.0013111220905557275,
0.028687166050076485,
-0.009685933589935303,
0.01807464472949505,
-0.0015628451947122812,
-0.019915467128157616,
0.011335261166095734,
-0.05564470216631889,
0.02404187247157097,
-0.029502563178539276,
-0.024906687438488007,
-0.0036013389471918344,
-0.045192789286375046,
-0.008734636940062046,
-0.038126010447740555,
-0.020940890535712242,
0.003693997859954834,
-0.02469666115939617,
0.0012779193930327892,
-0.03397489711642265,
0.011934454552829266,
-0.035902198404073715,
0.059647563844919205,
-0.030490925535559654,
0.00027546691126190126,
-0.024498987942934036,
-0.01664152182638645,
-0.08667922765016556,
0.02876129373908043,
0.00767214922234416,
0.012484230101108551,
0.024103643372654915,
-0.04808374494314194,
0.04405617341399193,
0.017456918954849243,
-0.013750567100942135,
0.012823978438973427,
0.010421027429401875,
-0.004404381848871708,
0.02333766408264637,
-0.006572598125785589,
-0.0360751636326313,
-0.0040430123917758465,
0.01381233986467123,
-0.013169905170798302,
0.01223096251487732,
-0.049096811562776566,
-0.012274202890694141,
-0.015443134121596813,
0.0243136715143919,
-0.014417710714042187,
0.006134013179689646,
-0.03703881427645683,
0.03703881427645683,
0.05678131803870201,
0.06547889113426208,
-0.004138760268688202,
0.030713306739926338,
0.0007671376806683838,
-0.05747316777706146,
-0.011773846112191677,
0.00088025868171826,
0.026315100491046906,
0.01832173392176628,
-0.013651730492711067,
0.028291821479797363,
0.022831130772829056,
0.003193640150129795,
0.023807136341929436,
0.014677154831588268,
0.04274659603834152,
-0.014924244955182076,
-0.004249950405210257,
-0.04346315935254097,
-0.0074374135583639145,
-0.000760574359446764,
0.006714674644172192,
0.005673807580024004,
-0.059647563844919205,
0.02414070814847946,
-0.025450285524129868,
-0.004731776192784309,
0.006254469510167837,
-0.023695945739746094,
-0.024214833974838257,
0.08361531049013138,
0.028020022436976433,
0.09621690213680267,
0.04679887369275093,
0.011131411418318748,
-0.016357367858290672,
-0.03375251591205597,
-0.022250467911362648,
-0.053816236555576324,
0.01158235128968954,
0.008981727063655853,
0.01696273870766163,
0.0016446937806904316,
0.02335001900792122,
-0.03550685569643974,
-0.04002860561013222,
0.004531015641987324,
0.052432529628276825,
0.004330255091190338,
0.002200646558776498,
-0.01804993487894535,
-0.04553871601819992,
0.05371739715337753,
-0.03523505479097366,
0.045884642750024796,
0.0333571694791317,
-0.03404902294278145,
0.006856751628220081,
-0.011205538176000118,
0.000546686933375895,
-0.0009219550993293524,
0.04358670115470886,
0.012996941804885864,
0.021299170330166817,
-0.036322250962257385,
-0.0012192354770377278,
0.05732491612434387,
-0.012873397208750248,
-0.016579749062657356,
0.0052908179350197315,
0.0347655825316906,
-0.020384937524795532,
0.0013443249044939876,
-0.07476948201656342,
0.011366146616637707,
0.02915663830935955,
0.013664085417985916,
0.013627021573483944,
-0.03429611399769783,
-0.01424474734812975,
-0.00023531475744675845,
-0.008845827542245388,
0.03684114292263985,
-0.011014043353497982,
0.014393000863492489,
-0.017704010009765625,
-0.027599969878792763,
-0.010402495041489601,
-0.02057025581598282,
-0.05856036767363548,
-0.010587813332676888,
0.0242889616638422,
-0.07047010958194733,
0.007177968975156546,
0.03488912805914879,
0.0430925227701664,
-0.027847060933709145,
0.010075100697577,
-0.022386368364095688,
-0.010044214315712452,
0.034938547760248184,
0.02680928073823452,
-0.00652935728430748,
0.01264483854174614,
-0.024103643372654915,
-0.008228101767599583,
-0.01872943341732025,
-0.030738014727830887,
0.0375082865357399,
0.005673807580024004,
0.05638597160577774,
-0.003845340572297573,
0.014627736993134022,
0.021743932738900185,
0.0053124381229281425,
-0.019557185471057892,
-0.010118342004716396,
-0.00874699093401432,
-0.02957669086754322,
0.04709538444876671,
0.03711294010281563,
-0.002639231737703085,
0.002297938335686922,
-0.0319487564265728,
0.0471942201256752,
0.011162297800183296,
-0.010939916595816612,
0.02207750454545021,
-0.012379216961562634,
-0.016332659870386124,
-0.05653422698378563,
0.011397032998502254,
-0.004493952263146639,
-0.006223583128303289,
0.021558616310358047,
-0.027847060933709145,
0.02876129373908043,
0.052136022597551346,
0.006875283550471067,
-0.0034994143061339855,
0.06399635225534439,
-0.006461407523602247,
0.03318420797586441,
-0.009895960800349712,
0.0048059034161269665,
-0.019235968589782715,
0.014430064707994461,
0.010624876245856285,
-0.021076789125800133,
-0.05569412186741829,
-0.026438646018505096,
-0.05292671173810959,
-0.02584563009440899,
0.004768840037286282,
0.00034515405423007905,
-0.025944465771317482,
-0.016073213890194893,
0.015776706859469414,
0.009383248165249825,
0.03901553526520729,
-0.015924960374832153,
-0.011236424557864666,
-0.0665660873055458,
-0.032566480338573456,
-0.04245008900761604,
0.032714735716581345,
0.008580205962061882,
0.02762467972934246,
0.027748223394155502,
-0.02057025581598282,
-0.016431495547294617,
-0.02333766408264637,
0.0360998697578907,
-0.017419856041669846,
0.0028492582496255636,
-0.004620586056262255,
-0.007060600910335779,
0.02057025581598282,
-0.004713244736194611,
0.0023427235428243876,
0.04086871072649956,
0.00628844415768981,
-0.030367380008101463,
0.0021743932738900185,
-0.02653748169541359,
0.04044865816831589,
-0.0142323924228549,
-0.0018902396550402045,
0.011254956014454365,
0.013491122052073479,
-0.009945378638803959,
-0.006356393918395042,
-0.04961570352315903,
-0.014133556745946407,
-0.0284894946962595,
-0.025042586028575897,
0.0041542029939591885,
0.018136417493224144,
-0.0012192354770377278,
-0.018247608095407486,
0.004775017034262419,
-0.00024689710699021816,
-0.010668117552995682,
-0.06177253648638725,
0.03096039593219757,
-0.037854209542274475,
0.0046391175128519535,
-0.006937055848538876,
-0.014417710714042187,
0.04556342214345932,
0.026562191545963287,
-0.03323362395167351,
0.04074516519904137,
-0.004846055526286364,
0.014763636514544487,
-0.020347874611616135,
-0.028983674943447113,
-0.02042200043797493,
0.060635924339294434,
-0.016765067353844643,
0.05351972579956055,
-0.03740944713354111,
-0.01305871456861496,
-0.0019458349561318755,
0.0005578832351602614,
0.02276935800909996,
0.024783141911029816,
0.02668573707342148,
0.013627021573483944,
-0.024943750351667404,
0.015406071208417416,
0.008234279230237007,
0.0037835680413991213,
-0.028267113491892815,
0.0026098897214978933,
0.020249037072062492,
-0.032146427780389786,
-0.006399634759873152,
-0.0222257599234581,
-0.018704723566770554,
0.0444268099963665,
0.012403925880789757,
-0.015319589525461197,
-0.005988847464323044,
0.0024353822227567434,
0.03901553526520729,
0.024634888395667076,
-0.005500844679772854,
0.005284640472382307,
0.008981727063655853,
0.02693282626569271,
-0.019767211750149727,
-0.02028610184788704,
0.011248779483139515,
-0.021570969372987747,
-0.03320891782641411,
-0.014887182042002678,
0.00704206945374608,
0.03303595259785652,
0.018297025933861732,
-0.03219584748148918,
0.00785746704787016,
-0.007591845002025366,
0.00022566280676983297,
0.011051107197999954,
0.005772643722593784,
-0.010976980440318584,
-0.02515377663075924,
0.029551982879638672,
-0.002205279655754566,
-0.05317379906773567,
0.020866762846708298,
0.015196043998003006,
-0.028390659019351006,
0.004947980400174856,
-0.013182259164750576,
0.025722084566950798,
0.011718250811100006,
-0.03693997859954834,
0.010316014289855957,
-0.005281552206724882,
0.0009335374925285578,
-0.016431495547294617,
-0.011014043353497982,
-0.008561673574149609,
-0.030070871114730835,
-0.035902198404073715,
0.022732293233275414,
-0.01916184090077877,
0.012836333364248276,
-0.03182521089911461,
-0.005059171002358198,
-0.0009443476446904242,
0.05080173537135124,
0.07160672545433044,
-0.007733921520411968,
0.03970738872885704,
-0.018284671008586884,
-0.01478834543377161,
-0.0021836592350155115,
-0.005655275657773018,
0.005519376136362553,
-0.007474476937204599,
0.010933739133179188,
0.014430064707994461,
0.09008906781673431,
0.011353792622685432,
-0.007295336574316025,
-0.019940175116062164,
-0.015307234600186348,
-0.007610376458615065,
-0.004197443835437298,
-0.00430863443762064,
-0.02055790089070797,
0.005411274265497923,
-0.01070518046617508,
-0.0070482464507222176,
-0.01984133943915367,
-0.07432471960783005,
0.016431495547294617,
0.0008123088628053665,
0.01305871456861496,
-0.008833472616970539,
0.00010636459046509117,
0.002931106835603714,
-0.023238828405737877,
-0.009234994649887085,
-0.0025573831517249346,
0.01914948597550392,
0.028242403641343117,
0.01506014447659254,
0.0013203880516812205,
-0.022534621879458427,
-0.024128353223204613,
-0.027698805555701256,
0.033554840832948685,
0.0026021681260317564,
0.08391181379556656,
-0.0036414910573512316,
0.012453343719244003,
-0.008771700784564018,
-0.008407242596149445,
-0.02957669086754322,
0.024103643372654915,
0.03876844421029091,
-0.0033017422538250685,
-0.004898562096059322,
-0.04820728674530983,
-0.01424474734812975,
-0.011279665865004063,
0.019112423062324524,
-0.006875283550471067,
0.032146427780389786,
0.008586382493376732,
-0.005754111800342798,
0.004518661182373762,
0.03083685040473938,
-0.02567266672849655,
-0.0035457436461001635,
0.043117232620716095,
0.044525645673274994,
-0.010353077203035355,
0.05860978364944458,
-0.018297025933861732,
-0.008611091412603855,
0.004388938657939434,
-0.014145910739898682,
-0.035605691373348236,
-0.028094150125980377,
-0.027847060933709145,
0.02110149897634983,
-0.024190125986933708,
0.01585083268582821,
-0.012533647939562798,
-0.006757915485650301,
0.03538331016898155,
-0.040646329522132874,
-0.03926262632012367,
0.013972948305308819,
-0.02221340499818325,
0.010402495041489601,
0.059795815497636795,
0.002992879366502166,
-0.026586899533867836,
0.00632241927087307,
0.0118170864880085,
0.009500616230070591,
-0.005460692569613457,
0.008388710208237171,
0.007801871746778488,
-0.039954476058483124,
0.010482799261808395,
0.017741072922945023,
-0.048800304532051086,
-0.020533191040158272,
-0.003907112870365381,
-0.0023504451382905245,
-0.006615838967263699,
-0.011631769128143787,
0.0022778622806072235,
0.023980099707841873,
0.02265816740691662,
0.021138561889529228,
-0.024968460202217102,
0.014380646869540215,
-0.02126210741698742,
-0.011224070563912392,
-0.0015906428452581167,
-0.005154918413609266,
0.00012383463035803288,
0.008586382493376732,
-0.02930489182472229,
0.012434812262654305,
-0.00152037653606385,
0.01305871456861496,
0.01561609748750925,
0.0028971319552510977,
-0.011903568170964718,
0.010550749488174915,
-0.01765459217131138,
-0.004438356962054968,
-0.007091487292200327,
0.022163987159729004,
-0.04435268044471741,
-0.011860326863825321,
-0.00025075790472328663,
0.010587813332676888,
-0.03360426053404808,
-0.018717078492045403,
0.0035148574970662594,
0.014850118197500706,
0.029675526544451714,
-0.07946418970823288,
-0.016579749062657356,
-0.0018500875448808074,
-0.03444436565041542,
-0.021620389074087143,
0.01969308592379093,
-0.022571684792637825,
-0.019742503762245178,
0.019507767632603645,
-0.004546458832919598,
-0.0015234652673825622,
-0.030070871114730835,
-0.009191753342747688,
-0.0027303462848067284,
-0.022423431277275085,
-0.004364229738712311,
-0.03293711692094803,
-0.035753946751356125,
0.006405812222510576,
0.04457506164908409,
0.015134272165596485,
0.007684503681957722,
-0.01762988232076168,
0.04766368865966797,
-0.006028999574482441,
-0.005448337644338608,
-0.00909909512847662,
-0.009877428412437439,
-0.020459065213799477,
0.006344039458781481,
0.03553156554698944,
0.023695945739746094,
-0.010173937305808067,
0.01333051361143589,
-0.001941201975569129,
-0.05480459704995155,
0.008716105483472347,
0.0012655648170039058,
-0.0037187067791819572,
-0.0031874629203230143,
0.01696273870766163,
0.008518433198332787,
0.020780282095074654,
0.006603484507650137,
-0.011959163472056389,
0.0005088512552902102,
-0.025524413213133812,
0.0009505249327048659,
0.02806944213807583,
-0.0235971100628376,
0.0045835222117602825,
-0.03041679784655571,
-0.03916379064321518,
0.0027766756247729063,
-0.01131672877818346,
0.001372122555039823,
-0.005411274265497923,
0.02057025581598282,
0.01834644377231598,
-0.022411076352000237,
-0.01257071178406477,
0.07027243822813034,
0.03543272614479065,
-0.029650818556547165,
0.014738927595317364,
-0.019001232460141182,
-0.04566226154565811,
0.034123148769140244,
-0.03654463216662407,
0.012249493971467018,
-0.017864618450403214,
-0.0019195816712453961,
-0.043537285178899765,
0.020916180685162544,
-0.00006572984420927241,
0.009846542961895466,
-0.011767668649554253,
-0.01194063201546669,
-0.004988132510334253,
0.002782852854579687,
-0.02042200043797493,
-0.03041679784655571,
-0.01541842520236969,
-0.000784511212259531,
-0.04608231410384178,
-0.026018593460321426,
0.014565964229404926,
0.033134788274765015,
-0.0014918068191036582,
-0.008376356214284897,
-0.030342670157551765,
-0.012972232885658741,
-0.010859612375497818,
0.008456660434603691,
-0.02710578963160515,
-0.012762206606566906,
-0.02900838293135166,
-0.013244031928479671,
0.008481369353830814,
-0.015134272165596485,
0.03876844421029091,
-0.04912152141332626,
0.028267113491892815,
-0.031207486987113953,
-0.019112423062324524,
-0.009117626585066319,
0.02900838293135166,
-0.011378501541912556,
-0.03318420797586441,
-0.006331684999167919,
0.029230764135718346,
0.02499316819012165,
0.04704596474766731,
0.0022763179149478674,
0.025796212255954742,
0.018222898244857788,
0.01834644377231598,
-0.023226473480463028,
0.007690681144595146,
0.03740944713354111,
0.07210090756416321,
0.029675526544451714,
0.015430780127644539,
-0.026982244104146957,
-0.026068011298775673,
-0.0006354849901981652,
0.03859548270702362,
0.0016076302854344249,
-0.003956531174480915,
0.005738668609410524,
0.014195329509675503,
0.009006435982882977,
-0.017592819407582283,
-0.024919042363762856,
0.003091715509071946,
0.03427140414714813,
0.03372780606150627,
0.025796212255954742,
0.0017543401336297393,
0.00931529887020588,
-0.004317900165915489,
-0.012935169041156769,
0.012811624445021152,
-0.0024986991193145514,
0.02611742913722992,
-0.01719747483730316,
-0.03110864944756031,
0.03501267358660698,
-0.011866504326462746,
0.05317379906773567,
-0.025647956877946854,
0.03056505136191845,
0.01973014883697033,
0.051048826426267624,
0.0009528414229862392,
0.042277123779058456,
-0.003105614334344864,
-0.025796212255954742,
-0.03446907550096512,
0.012416279874742031,
-0.02388126403093338,
0.06369984149932861,
-0.03056505136191845,
-0.027031661942601204,
0.02903309278190136,
-0.024498987942934036,
-0.020879117771983147,
-0.0032986535225063562,
0.0022886726073920727,
0.021360943093895912,
0.04289485141634941,
-0.041313473135232925,
0.03879315406084061,
-0.014677154831588268,
-0.006013556383550167,
-0.01707392930984497,
-0.0015412247739732265,
0.01527017168700695,
0.02442486211657524,
0.022707585245370865,
-0.03041679784655571,
0.0014933510683476925,
0.00558423763141036,
0.005130209494382143,
-0.002165127545595169,
0.004089341964572668,
-0.016036150977015495,
-0.03649521619081497,
0.04773781821131706,
0.002098721917718649,
-0.015554324723780155,
-0.020767927169799805,
0.010204823687672615,
0.05371739715337753,
0.02789647877216339,
-0.02415306307375431,
-0.03718706965446472,
0.011075816117227077,
-0.039237916469573975,
-0.027599969878792763,
-0.0416346900165081,
0.044229138642549515,
0.03545743599534035,
-0.02861304022371769,
-0.011471160687506199,
0.008870536461472511,
-0.0005420540110208094,
-0.028415367007255554,
0.018136417493224144,
0.0430678129196167,
0.00740035017952323,
0.015566679649055004,
-0.05099940672516823,
-0.00021215005835983902,
0.01221860758960247,
-0.004759573843330145,
-0.012508939020335674,
-0.010118342004716396,
-0.03128161281347275,
-0.016703294590115547,
-0.040473368018865585,
-0.032418228685855865,
0.011156120337545872,
-0.01762988232076168,
-0.0013172993203625083,
-0.003003689693287015,
0.03938617184758186,
0.02208985947072506,
-0.006239026319235563,
0.02737758867442608,
-0.024807851761579514,
0.026710445061326027,
0.005469958297908306,
-0.025326739996671677,
-0.011841795407235622,
-0.016604458913207054,
-0.005108588840812445,
-0.02708107978105545,
0.005466869566589594,
-0.03508680313825607,
0.049516867846250534,
-0.006257558241486549,
0.008067493326961994,
-0.0023195587564259768,
-0.001259387587197125,
-0.007523895241320133,
0.0347408764064312,
-0.03802717477083206,
-0.02472136914730072,
0.02928018383681774,
-0.028637748211622238,
0.0018840624252334237,
0.033554840832948685,
0.03651992604136467,
0.04373495653271675,
-0.0032276150304824114,
-0.009414134547114372,
0.0038793154526501894,
0.030466215685009956,
0.007542426697909832,
-0.013095778413116932,
0.011094347573816776,
0.02054554596543312,
-0.007350931875407696,
0.021459778770804405,
-0.008963195607066154,
-0.0012663369998335838,
-0.023955389857292175,
-0.010841079987585545,
0.008536964654922485,
0.0029527272563427687,
0.011637946590781212,
-0.014405355788767338,
0.0097291748970747,
-0.02236165851354599,
-0.03642108663916588,
0.036594051867723465,
-0.0023504451382905245,
0.013676440343260765,
0.003981240093708038,
-0.014022366143763065,
-0.003888581180945039,
-0.005383476614952087,
0.006974119693040848,
0.02789647877216339,
-0.007851289585232735,
-0.004744131118059158,
-0.03281357139348984,
0.033332459628582,
-0.022324595600366592,
-0.023238828405737877,
0.020607318729162216,
-0.017407501116394997,
0.01581376977264881,
0.003975062631070614,
-0.021435070782899857,
0.0035148574970662594,
-0.013775276020169258,
0.017802845686674118,
-0.01720982976257801,
0.015887897461652756,
0.02710578963160515,
0.002243887400254607,
-0.03958384320139885,
0.002623788546770811,
-0.011094347573816776,
-0.0026994599029421806,
-0.022967029362916946,
0.022719940170645714,
-0.011983872391283512,
-0.04773781821131706,
0.011971517466008663,
0.0006663712556473911,
-0.0029650817159563303,
0.01640678569674492,
0.010711357928812504,
-0.005741757340729237,
0.019643666222691536,
0.0017388969426974654,
-0.00012779193639289588,
0.004080076236277819,
0.0024770786985754967,
0.018259963020682335,
-0.012996941804885864,
-0.006918524391949177,
-0.0018315557390451431,
0.0075486041605472565,
-0.01450419146567583,
-0.016147341579198837,
-0.025030232965946198,
-0.0024508254136890173,
-0.008178683929145336,
0.003477793885394931,
0.0008447394357062876,
-0.012484230101108551,
0.017160411924123764,
0.0030283986125141382,
0.003511768765747547,
0.007684503681957722,
-0.035605691373348236,
0.0007559414370916784,
0.005540996789932251,
0.008382533676922321,
0.009272057563066483,
0.030515633523464203,
-0.00003397489490453154,
0.00980330165475607,
-0.03323362395167351,
-0.018086999654769897,
-0.009129981510341167,
0.06992651522159576,
0.0036167821381241083,
-0.028291821479797363,
0.02720462530851364,
0.013478768058121204,
-0.010075100697577,
0.0016585926059633493,
0.012354507111012936,
-0.003344982862472534,
-0.0005100095295347273,
-0.023127637803554535,
0.020928535610437393,
0.02470901422202587,
-0.018395861610770226,
0.01611027866601944,
0.02876129373908043,
-0.023695945739746094,
0.004947980400174856,
-0.009920669719576836,
0.017963454127311707,
0.008067493326961994,
0.007616553921252489,
-0.004447622690349817,
0.003749593161046505,
0.0033418943639844656,
0.019421285018324852,
0.03864489868283272,
0.003588984487578273,
0.013577603735029697,
0.032171137630939484,
0.015924960374832153,
0.007882175967097282,
-0.018111707642674446,
-0.03278886154294014,
0.017716363072395325,
-0.03572923690080643,
-0.03525976464152336,
-0.02873658388853073,
0.009667402133345604,
-0.01522075291723013,
-0.011650300584733486,
-0.019273031502962112,
0.02957669086754322,
0.015801414847373962,
-0.037162359803915024,
-0.0067826248705387115,
0.006232848856598139,
-0.0006142506608739495,
0.008191038854420185,
0.015492552891373634,
-0.019754856824874878,
-0.03209701180458069,
0.006980296690016985,
-0.0235971100628376,
-0.003406755393370986,
0.0057788207195699215,
-0.0017157322727143764,
0.010538394562900066,
0.015900250524282455,
-0.011378501541912556,
-0.026586899533867836,
-0.02557383105158806,
-0.042573634535074234,
0.016975093632936478,
-0.019137132912874222,
-0.02026139199733734,
-0.005284640472382307,
0.006195785477757454,
-0.02638922818005085,
-0.020174911245703697,
0.016196759417653084,
0.004324077628552914,
-0.0021280639339238405,
-0.010056569240987301,
0.006028999574482441,
-0.005355678964406252,
0.007147082593291998,
0.017716363072395325,
-0.04390792176127434,
0.050060465931892395,
-0.014763636514544487,
0.026166846975684166,
0.005398919805884361,
0.00854314211755991,
-0.022732293233275414,
-0.007128550671041012,
-0.007684503681957722,
0.03177579492330551,
-0.024943750351667404,
0.005229045171290636,
-0.005151829682290554,
-0.005729402881115675,
0.05544703081250191,
0.00708531029522419,
0.009692111052572727,
0.0047503081150352955,
-0.011860326863825321,
-0.022831130772829056,
0.028860129415988922,
0.004781194496899843,
0.01692567579448223,
0.032294683158397675,
-0.03906495124101639,
-0.006436698604375124,
-0.01569022424519062,
-0.006856751628220081,
-0.03108394145965576,
-0.027847060933709145,
0.0022330773063004017,
0.031602829694747925,
-0.02122504450380802,
0.007295336574316025,
-0.019248323515057564,
0.018235253170132637,
0.01832173392176628,
-0.010575458407402039,
-0.00847519189119339,
-0.0011366147082298994,
-0.002668573521077633,
-0.008919954299926758,
0.011607060208916664,
0.01681448519229889,
0.013367577455937862,
0.0173827912658453,
0.010581635870039463,
-0.03288770094513893,
0.010031860321760178,
0.009908314794301987,
0.009111449122428894,
0.00024921356816776097,
-0.026315100491046906,
0.0034592621959745884,
-0.005927075166255236,
0.014294165186583996,
0.020298456773161888,
0.027945896610617638,
-0.026166846975684166,
-0.018803561106324196,
0.040646329522132874,
-0.0038638722617179155,
0.003002145327627659,
-0.009895960800349712,
-0.007919239811599255,
-0.01333051361143589,
-0.007888353429734707,
-0.015603743493556976,
0.0009466641349717975,
-0.022052796557545662,
0.010871966369450092,
0.005806618370115757,
0.006112392526119947,
-0.023794781416654587,
-0.014677154831588268,
-0.03234409913420677,
0.01735808327794075,
-0.008438128978013992,
-0.023807136341929436,
-0.042005326598882675,
0.003598250215873122,
0.004073898773640394,
-0.05347030982375145,
-0.011063461191952229,
-0.016765067353844643,
0.00430863443762064,
0.02710578963160515,
-0.027995314449071884,
0.011563818901777267,
0.03345600515604019,
0.0050375503487885,
-0.009179399348795414,
0.0222010500729084,
0.0416593998670578,
0.02335001900792122,
-0.028118859976530075,
-0.024202480912208557,
-0.03184992074966431,
0.002511053578928113,
0.047836653888225555,
-0.020730864256620407,
0.0374835766851902,
-0.0019056828459724784,
-0.03399960324168205,
0.02027374692261219,
0.021274462342262268,
-0.01313284132629633,
0.06864164769649506,
0.022608749568462372,
-0.0021913808304816484,
-0.030070871114730835,
-0.010451913811266422,
-0.013837048783898354,
0.028118859976530075,
0.0305403433740139,
-0.007122373674064875,
-0.0033017422538250685,
-0.0002395616174908355,
0.03973209485411644,
-0.027995314449071884,
-0.028687166050076485,
0.004175823647528887,
0.03427140414714813,
-0.00392873352393508,
-0.007165614515542984,
0.018136417493224144,
-0.001284868805669248,
-0.03723648563027382,
-0.005176538601517677,
0.00413567153736949,
-0.04620585963129997,
-0.006974119693040848,
-0.019384222105145454,
0.019643666222691536,
0.008289874531328678,
0.004080076236277819,
-0.009895960800349712,
0.014010011218488216,
-0.011650300584733486,
0.0014045530697330832,
-0.02638922818005085,
0.0006254469626583159,
-0.011959163472056389,
-0.01464009191840887,
-0.003996683284640312,
-0.013009296730160713,
-0.00458043348044157,
0.017469273880124092,
0.004490863531827927,
0.029403727501630783,
-0.017728717997670174,
-0.02110149897634983,
-0.009469729848206043,
-0.014911890961229801,
-0.03834839165210724,
0.004018303472548723,
-0.009000258520245552,
-0.010044214315712452,
-0.042301833629608154,
-0.015579033643007278,
0.010933739133179188,
0.0056799850426614285,
-0.038817863911390305,
0.014603028073906898,
-0.0048059034161269665,
-0.02043435536324978,
0.02819298580288887,
0.027130499482154846,
-0.00315657677128911,
0.006980296690016985,
-0.04615643993020058,
-0.008092202246189117,
-0.05169126018881798,
0.01969308592379093,
-0.008425774052739143,
-0.01639443077147007,
6.334097975013719e-7,
-0.02752584218978882,
-0.015121917240321636,
-0.03553156554698944,
-0.02276935800909996,
-0.009821833111345768,
-0.015900250524282455,
-0.0019273031502962112,
0.01478834543377161,
0.008320760913193226,
-0.0034098441246896982,
0.0001874410518212244,
-0.021496843546628952,
-0.008178683929145336,
0.029057802632451057,
0.04123934730887413,
0.008351647295057774,
0.04259834066033363,
-0.00985889695584774,
0.021991023793816566,
0.006523179821670055,
0.02596917562186718,
-0.023374728858470917,
-0.00859873741865158,
0.03014499880373478,
-0.008382533676922321,
-0.01875414326786995,
0.0312321949750185,
-0.009970087558031082,
-0.022596394643187523,
0.006807333789765835,
-0.007808048743754625,
-0.009852719493210316,
0.0019381133606657386,
-0.0047286879271268845,
0.026710445061326027,
-0.02540086768567562,
0.014911890961229801,
0.016715649515390396,
0.0180622898042202,
-0.02984848991036415,
0.05183951556682587,
0.016283240169286728,
-0.025895047932863235,
0.006807333789765835,
-0.007418881636112928,
-0.028217695653438568,
0.013157550245523453,
-0.01304635964334011,
-0.002123431069776416,
0.02834124118089676,
0.010248064063489437,
-0.0065417117439210415,
0.02196631394326687,
-0.013627021573483944,
0.003990505822002888,
0.023090574890375137,
-0.013194614090025425,
0.026191556826233864,
0.018371153622865677,
0.015566679649055004,
0.00922881718724966,
0.02668573707342148,
-0.005006663966923952,
-0.059252217411994934,
0.020607318729162216,
-0.03681643307209015,
-0.014973662793636322,
-0.024820204824209213,
0.006424344144761562,
0.09285648167133331,
0.0033264511730521917,
-0.00014362114598043263,
0.019137132912874222,
-0.02276935800909996,
-0.017321020364761353,
0.006310064811259508,
0.031009813770651817,
0.0277729332447052,
-0.03372780606150627,
0.02043435536324978,
0.029947325587272644,
0.0235971100628376,
0.018395861610770226,
0.013540539890527725,
-0.011662655510008335,
0.0042653935961425304,
0.031454578042030334,
0.007480654399842024,
-0.003724884008988738,
0.011619414202868938,
0.02457311563193798,
-0.0042283302173018456,
0.018803561106324196,
-0.011217893101274967,
-0.017951099202036858,
-0.0017651502275839448,
-0.015603743493556976,
-0.031602829694747925,
0.006331684999167919,
0.0017697832081466913,
0.007097664754837751,
-0.0008347014081664383,
-0.00951914768666029,
-0.014578319154679775,
0.0031025256030261517,
-0.02375771850347519,
-0.0070482464507222176,
0.013454059138894081,
-0.009636515751481056,
-0.0031751084607094526,
0.008919954299926758,
-0.005009752698242664,
0.01305871456861496,
0.024511342868208885,
-0.0222010500729084,
-0.03805188462138176,
-0.018927104771137238,
0.007511540781706572,
0.0008686762885190547,
-0.0000622068764641881,
0.003005234058946371,
0.016159696504473686,
-0.01090285275131464,
-0.013281095772981644,
-0.029131928458809853,
0.014553610235452652,
-0.010519863106310368,
-0.010976980440318584,
-0.015517261810600758,
-0.04123934730887413,
0.01722218282520771,
-0.012873397208750248,
0.029897907748818398,
0.0040399241261184216
] | 2025-01-17 | 1 | 39820359 | [
"high response rates",
"durable responses",
"extramedullary responses",
"anti-CAR immune responses",
"high marrow burden",
"low marrow disease burden",
"marrow disease",
"CD19 CAR T-cells",
"Durable remissions",
"patients",
"vivo CAR T-cell expansion",
"most adults",
"prolong remissions",
"JCAR021 infusion",
"adults",
"MRD-negative marrow responses",
"CAR",
"CR",
"remission",
"scFv",
"these CD8+ T-cell responses",
"new strategies",
"JCAR021",
"R/R B",
"DOR",
"second infusions",
"lymphodepletion chemotherapy",
"CD19-directed chimeric antigen receptor-engineered (CD19 CAR) T-cell therapy",
"the murine single chain variable fragment",
"similar outcomes"
] | [] | 0 | 10.1182/bloodadvances.2024015314 | [
"Gauthier",
"Liang",
"Huang",
"Kimble",
"Hirayama",
"Fiorenza",
"Voutsinas",
"Wu",
"Jaeger-Ruckstuhl",
"Pender",
"Kirchmeier",
"Torkelson",
"Braathen",
"Basom",
"Shadman",
"Kopmar",
"Cassaday",
"Riddell",
"Maloney",
"Turtle"
] | [
"University of Washington, United States.",
"Fred Hutchinson Cancer Center, United States.",
"Fred Hutchinson Cancer Center, Seattle, Washington, United States.",
"University of Washington, United States.",
"University of Washington, United States.",
"University of Sydney, Camperdown, Australia.",
"Fred Hutch Cancer Center, Seattle, Washington, United States.",
"Fred Hutchinson Cancer Center, Seattle, Washington, United States.",
"Fred Hutchinson Cancer Research Center, Seattle, Washington, United States.",
"Fred Hutchinson Cancer Research Center, Seattle, Washington, United States.",
"Fred Hutchinson Cancer Center, Seattle, Washington, United States.",
"Fred Hutchinson Cancer Center, Seattle, Washington, United States.",
"Fred Hutch Cancer Center, Seattle, Washington, United States.",
"Fred Hutchinson Cancer Research Center, Seattle, Washington, United States.",
"University of Washington, United States.",
"Fred Hutch Cancer Center, United States.",
"University of Washington, United States.",
"University of Washington, United States.",
"Fred Hutchinson Cancer Center, Seattle, Washington, United States.",
"Fred Hutchinson Cancer Center, United States."
] | [
"39820359"
] | [] | 6.589711 | 5.630523 |
39818472 | 21 | Mechanisms for resistance to BCMA-targeted immunotherapies in multiple myeloma. | Multiple myeloma (MM) remains incurable and patients eventually face the relapse/refractory dilemma. B cell maturation antigen (BCMA)-targeted immunotherapeutic approaches have shown great effectiveness in patients with relapsed/refractory MM, mainly including chimeric antigen receptor T cells (CAR-T), bispecific T cell engagers (TCEs), and antibody-drug conjugates (ADCs). However, their impact on long-term survival remains to be determined. Nonetheless, resistance to these novel therapies is still inevitable, raising a challenge that we have never met in both laboratory research and clinical practice. In this scenario, the investigation aiming to enhance and prolong the anti-MM activity of BCMA-targeted therapies has been expanding rapidly. Despite considerable uncertainty in our understanding of the mechanisms for their resistance, they have mainly been attributed to antigen-dependency, T cell-driven factors, and (immune) tumor microenvironment. In this review, we summarize the current understanding of the mechanisms for resistance to BCMA-targeted immunotherapies and discuss potential strategies for overcoming it. | [
0.02563696727156639,
0.03418262302875519,
0.09152283519506454,
0.04216192290186882,
-0.06463988870382309,
0.002531288657337427,
-0.0003626240068115294,
-0.002380260732024908,
-0.015442591160535812,
-0.009168645367026329,
0.013403715565800667,
-0.029173534363508224,
-0.022024884819984436,
0.02494475618004799,
0.03476156294345856,
0.005219897720962763,
0.023384135216474533,
0.00023381775827147067,
-0.005682420451194048,
0.05527617037296295,
0.014246954582631588,
0.017720593139529228,
0.01298838946968317,
-0.0020278627052903175,
-0.023321207612752914,
-0.006601172965019941,
-0.06106556951999664,
0.01638651452958584,
-0.021672487258911133,
-0.014360224828124046,
0.032697513699531555,
-0.03443433344364166,
-0.04613898694515228,
0.008583412505686283,
-0.048781976103782654,
0.006258213892579079,
0.010609702207148075,
-0.014435739256441593,
-0.005861765705049038,
0.00934484414756298,
0.022767439484596252,
-0.004675568547099829,
-0.0076709529384970665,
0.0797426700592041,
-0.036120813339948654,
0.018526075407862663,
-0.008388334885239601,
-0.03151446580886841,
0.02402600273489952,
0.017984891310334206,
-0.027336029335856438,
0.029903501272201538,
-0.019004330039024353,
0.04691929742693901,
-0.04150747135281563,
0.001179904560558498,
-0.03018038533627987,
0.011496989987790585,
0.014020413160324097,
-0.002913577714934945,
0.010874000377953053,
-0.025523696094751358,
-0.010175497271120548,
-0.0051538231782615185,
-0.046290017664432526,
-0.01892881654202938,
0.0024431890342384577,
-0.030130043625831604,
0.002089217770844698,
-0.019520340487360954,
-0.014964336529374123,
-0.05185287445783615,
0.011717239394783974,
0.03294922783970833,
0.011119420640170574,
0.009143473580479622,
-0.005078309215605259,
0.00439868401736021,
-0.010534187778830528,
0.0007775570848025382,
0.002278002444654703,
0.005559710320085287,
0.011723531410098076,
-0.019054671749472618,
0.008086279034614563,
0.06977483630180359,
-0.004873792640864849,
-0.012963218614459038,
-0.04875680431723595,
-0.030784497037529945,
-0.024667872115969658,
-0.007293383590877056,
-0.03919171169400215,
0.04367220029234886,
-0.013718357309699059,
0.007677245885133743,
-0.005418121814727783,
-0.0824611708521843,
0.0181359201669693,
0.05301075428724289,
0.002547020558267832,
0.019734296947717667,
0.009307087399065495,
-0.011767582036554813,
0.05074533447623253,
-0.07304710894823074,
-0.02388756163418293,
-0.022339526563882828,
0.013693185523152351,
0.0261781495064497,
0.0383358858525753,
-0.02494475618004799,
-0.008413506671786308,
0.026027122512459755,
-0.015190877951681614,
-0.04045027494430542,
-0.02607746422290802,
0.02132008969783783,
0.005575442221015692,
0.029299389570951462,
-0.013957484625279903,
0.07183888554573059,
0.017103897407650948,
-0.05880014970898628,
0.02046426571905613,
-0.02203747071325779,
0.08371973782777786,
-0.02556145191192627,
-0.031464122235774994,
-0.05779330059885979,
0.0557795949280262,
-0.005572296213358641,
0.03768143430352211,
-0.033880565315485,
-0.07662142813205719,
0.004367220215499401,
-0.03503844514489174,
-0.021093547344207764,
-0.03997202217578888,
-0.004197313915938139,
0.002998530864715576,
-0.012673748657107353,
-0.004404976963996887,
0.01531673502177,
-0.006645222660154104,
-0.03720317780971527,
0.03425813466310501,
0.002771989209577441,
0.02187385782599449,
0.00452454062178731,
-0.029953844845294952,
0.019457412883639336,
0.0120633440092206,
0.0008125609601847827,
-0.0009148193639703095,
-0.06519366055727005,
-0.03224443271756172,
0.07355052977800369,
-0.025372667238116264,
-0.05336315184831619,
-0.019243456423282623,
0.007230455055832863,
-0.018777787685394287,
-0.02042650803923607,
0.04840440675616264,
0.06418681144714355,
-0.017103897407650948,
0.04180952534079552,
-0.033830225467681885,
-0.010483845137059689,
0.006689272355288267,
-0.017015798017382622,
-0.07636971771717072,
-0.05779330059885979,
-0.03083483874797821,
-0.007387775927782059,
0.011729824356734753,
-0.023774290457367897,
-0.026681575924158096,
-0.011861974373459816,
0.002244965173304081,
-0.0019130186410620809,
0.028594594448804855,
-0.011868266388773918,
-0.04062647372484207,
-0.002633546944707632,
-0.025372667238116264,
0.030230728909373283,
-0.023937903344631195,
-0.020489435642957687,
0.0009156059240922332,
0.016436858102679253,
0.06257584691047668,
-0.002628827467560768,
-0.003322611330077052,
-0.013227516785264015,
0.04203606769442558,
0.010867707431316376,
-0.03315059840679169,
-0.009628021158277988,
0.025611795485019684,
-0.035340502858161926,
0.024038588628172874,
-0.02635434828698635,
-0.04261500760912895,
-0.0055817351676523685,
0.015581033192574978,
0.02231435477733612,
-0.01442315336316824,
0.024894412606954575,
0.03304991498589516,
-0.0014740941114723682,
0.03999719023704529,
0.004596908111125231,
-0.042388465255498886,
-0.03609564155340195,
-0.01580757461488247,
0.0251587126404047,
-0.00628023874014616,
0.038688283413648605,
0.044125284999608994,
0.006834007333964109,
-0.008872882463037968,
0.040123049169778824,
-0.04216192290186882,
0.008174378424882889,
0.008986153639853,
0.007884909398853779,
-0.02553628198802471,
0.014913993887603283,
-0.004505662247538567,
-0.016776669770479202,
0.03171583637595177,
-0.018400218337774277,
-0.03886448219418526,
-0.02008669637143612,
-0.00022437851293943822,
0.04608864709734917,
0.054772742092609406,
-0.022855538874864578,
0.05127393454313278,
0.037731774151325226,
0.054017603397369385,
-0.011780166998505592,
-0.052104584872722626,
0.014020413160324097,
-0.012459792196750641,
-0.07682280242443085,
0.0335281677544117,
-0.0075388033874332905,
-0.019419655203819275,
0.01636134274303913,
-0.020653050392866135,
0.01346664410084486,
0.009734999388456345,
0.002517129760235548,
-0.0013828481314703822,
0.03405676409602165,
0.016059288755059242,
-0.006409241817891598,
-0.031162066385149956,
0.04739755392074585,
-0.025825751945376396,
-0.018224019557237625,
-0.045056622475385666,
0.04218709468841553,
-0.03778211772441864,
-0.009093130938708782,
0.08814988285303116,
-0.012975803576409817,
-0.0075388033874332905,
0.014586767181754112,
-0.0006041111191734672,
-0.017531808465719223,
-0.026379520073533058,
-0.01346664410084486,
0.009747585281729698,
0.042388465255498886,
-0.009565092623233795,
0.02066563442349434,
-0.003171583404764533,
-0.008256185799837112,
0.02563696727156639,
-0.03803383186459541,
0.013479229994118214,
-0.005141237750649452,
0.01208222284913063,
-0.018161091953516006,
-0.009829391725361347,
-0.02940007485449314,
-0.005267093889415264,
-0.006211017724126577,
-0.012208078987896442,
-0.025951607152819633,
-0.017720593139529228,
-0.01389455609023571,
0.02032582275569439,
-0.02542301081120968,
-0.031187238171696663,
0.07450704276561737,
-0.023056909441947937,
0.028594594448804855,
-0.0393679104745388,
-0.03876379877328873,
0.021005447953939438,
-0.0010815792484208941,
-0.01807299256324768,
-0.04719618335366249,
0.003992796875536442,
0.054772742092609406,
0.02042650803923607,
-0.03007970005273819,
0.024793727323412895,
0.023736532777547836,
-0.012069636955857277,
-0.0066389297135174274,
0.005912108346819878,
-0.040878187865018845,
-0.0017305266810581088,
-0.0362718403339386,
-0.007928959093987942,
0.00008072513446677476,
-0.05633336305618286,
-0.01153474673628807,
0.01178645994514227,
-0.04842957481741905,
0.0021820368710905313,
-0.03536567464470863,
0.02050202153623104,
-0.05683679133653641,
0.025511110201478004,
0.009143473580479622,
0.05041810870170593,
-0.020300650969147682,
-0.008665218949317932,
0.002322052139788866,
-0.010049640201032162,
-0.005279679782688618,
0.024239959195256233,
-0.007029084954410791,
-0.020590120926499367,
0.01566913351416588,
-0.023975661024451256,
0.03498810529708862,
0.034962933510541916,
-0.02303173765540123,
-0.013013561256229877,
0.023736532777547836,
-0.019105015322566032,
0.01687735505402088,
0.04596278816461563,
0.0020797783508896828,
0.020376164466142654,
-0.003322611330077052,
-0.01067892275750637,
0.016537543386220932,
0.005455878563225269,
-0.021508874371647835,
0.03322611376643181,
-0.020350994542241096,
-0.01704096794128418,
-0.0023723947815597057,
-0.008350578136742115,
0.03654872253537178,
0.052205272018909454,
0.06524400413036346,
0.003476785495877266,
0.01158508937805891,
-0.024957342073321342,
-0.0022087814286351204,
-0.010477552190423012,
0.019256042316555977,
0.0019948254339396954,
0.01721716672182083,
-0.026228491216897964,
0.03299957141280174,
0.012126272544264793,
0.010559359565377235,
-0.004609494004398584,
0.01361767202615738,
0.034031596034765244,
-0.04634035751223564,
0.014586767181754112,
-0.012554184533655643,
0.009319673292338848,
0.04082784429192543,
0.008287649601697922,
-0.0304572694003582,
-0.08996221423149109,
0.007255626376718283,
0.004137531854212284,
-0.010156618431210518,
-0.007060548756271601,
0.0009612289140932262,
-0.03904068097472191,
0.03113689459860325,
-0.02587609365582466,
0.0763193741440773,
0.04978882521390915,
0.04241363704204559,
0.0029072847682982683,
-0.034887418150901794,
-0.021294917911291122,
-0.036599066108465195,
0.004807717632502317,
-0.006113478913903236,
0.01666339859366417,
-0.0077338810078799725,
0.040601301938295364,
-0.010458674281835556,
-0.02932456135749817,
0.026480205357074738,
0.03342748433351517,
0.014586767181754112,
0.014649694785475731,
-0.005550270900130272,
-0.020791491493582726,
0.05074533447623253,
0.008979860693216324,
0.004615786485373974,
-0.015971187502145767,
-0.02502026967704296,
0.034887418150901794,
-0.015794988721609116,
-0.019444826990365982,
-0.011144592426717281,
0.042589835822582245,
-0.0014339773915708065,
-0.02289329469203949,
-0.028670107945799828,
-0.037631090730428696,
0.08195774257183075,
0.017053553834557533,
-0.013907141983509064,
-0.003794573014602065,
0.0513242743909359,
-0.06826455891132355,
0.003037861082702875,
-0.03330162540078163,
0.004027407616376877,
-0.014725209213793278,
-0.013655428774654865,
-0.04339531809091568,
-0.005833448376506567,
0.01943224109709263,
0.06222344934940338,
-0.016449442133307457,
0.036020126193761826,
-0.011006149463355541,
-0.01526639237999916,
0.02442874386906624,
-0.0783834233880043,
0.03632218390703201,
0.014196611940860748,
-0.019960839301347733,
-0.012604527175426483,
0.059353917837142944,
-0.05447068810462952,
-0.0026099488604813814,
0.005786252208054066,
0.04100404307246208,
-0.08814988285303116,
0.02114388905465603,
-0.0403747595846653,
-0.03921687975525856,
0.018979158252477646,
0.05356452241539955,
-0.0038889655843377113,
-0.012774433940649033,
-0.03556704521179199,
0.04608864709734917,
0.02997901476919651,
-0.03277302905917168,
-0.010496431030333042,
-0.0352398157119751,
0.03987133502960205,
-0.006563415750861168,
0.016248073428869247,
0.039820991456508636,
0.0025989364366978407,
0.011843095533549786,
-0.002529715420678258,
-0.011471819132566452,
-0.014410567469894886,
-0.018727445974946022,
0.05016639456152916,
-0.04807717725634575,
0.019998595118522644,
-0.017191996797919273,
0.026480205357074738,
0.010087397880852222,
-0.021395603194832802,
-0.0013553170720115304,
-0.012774433940649033,
-0.0015149974497035146,
-0.03808417171239853,
0.001520503661595285,
-0.04352117329835892,
-0.03272268548607826,
0.014171440154314041,
-0.020250309258699417,
0.012925460934638977,
0.003958186600357294,
0.007803102023899555,
0.016789255663752556,
0.027059145271778107,
0.011861974373459816,
0.05663542076945305,
0.0031055088620632887,
0.037253521382808685,
-0.0633309856057167,
-0.011163470335304737,
0.02080407738685608,
-0.005352047272026539,
-0.01875261589884758,
-0.007966715842485428,
-0.027638085186481476,
-0.0160844586789608,
0.004785692784935236,
0.020338408648967743,
0.015304149128496647,
-0.0031873155385255814,
-0.0011909169843420386,
0.03652355447411537,
0.02231435477733612,
-0.0444776825606823,
-0.034031596034765244,
0.022188499569892883,
-0.02761291339993477,
-0.016071872785687447,
-0.010905465111136436,
-0.0065760016441345215,
-0.008331699296832085,
0.006821421440690756,
-0.00946440827101469,
-0.04112990200519562,
-0.015820160508155823,
0.016248073428869247,
-0.032496146857738495,
-0.048102349042892456,
0.027713598683476448,
-0.021508874371647835,
0.01789679192006588,
-0.0007232815260067582,
-0.015530690550804138,
0.029953844845294952,
-0.005779959261417389,
0.020338408648967743,
0.013428887352347374,
0.006402948871254921,
0.017229752615094185,
-0.014095926657319069,
0.014335053972899914,
-0.013579915277659893,
0.025775408372282982,
-0.03642286732792854,
-0.02675708942115307,
-0.007645781617611647,
-0.0027515373658388853,
-0.011522161774337292,
-0.0009706681594252586,
-0.023384135216474533,
0.02627883478999138,
-0.0287456214427948,
-0.002627254230901599,
-0.002064046449959278,
-0.015392248518764973,
-0.009470700286328793,
-0.026983631774783134,
0.021307503804564476,
-0.0033886858727782965,
0.01855124719440937,
-0.0031306801829487085,
-0.04042510315775871,
0.007935251109302044,
0.004282266832888126,
0.0038889655843377113,
0.02368619106709957,
0.004458466079086065,
-0.003709619864821434,
-0.017531808465719223,
-0.029374904930591583,
-0.02864493615925312,
0.03556704521179199,
-0.016713742166757584,
0.01649978570640087,
-0.04274086281657219,
-0.010987271554768085,
-0.03121240809559822,
0.026782261207699776,
0.011050200089812279,
-0.043823227286338806,
0.017506636679172516,
-0.00987344142049551,
-0.007645781617611647,
0.021445944905281067,
-0.015832746401429176,
-0.0010988845024257898,
-0.022956224158406258,
-0.00539924344047904,
0.03347782418131828,
-0.022566068917512894,
-0.025926437228918076,
-0.01940707117319107,
-0.0024306033737957478,
0.07088237255811691,
0.005361486226320267,
-0.015857918187975883,
-0.008224721066653728,
0.027336029335856438,
0.0251587126404047,
0.055527880787849426,
-0.02337154932320118,
-0.02050202153623104,
-0.0004369579837657511,
0.014951750636100769,
-0.034585364162921906,
-0.008816246874630451,
0.0007295743562281132,
0.0032345117069780827,
-0.001252272049896419,
0.021231990307569504,
-0.017884206026792526,
0.003022128948941827,
0.002101803431287408,
-0.05527617037296295,
-0.029148362576961517,
-0.005946719087660313,
0.044200800359249115,
0.0032596830278635025,
-0.008595998398959637,
-0.032697513699531555,
-0.015996359288692474,
-0.001314413733780384,
0.021508874371647835,
-0.01067892275750637,
0.04679344221949577,
-0.01512794941663742,
0.004615786485373974,
-0.014284711331129074,
-0.013391130603849888,
0.0036938879638910294,
-0.004033700563013554,
-0.004172142595052719,
-0.004508808720856905,
-0.045836932957172394,
0.0016023104544728994,
-0.0006564202485606074,
-0.007853444665670395,
-0.022566068917512894,
-0.0033320505172014236,
-0.00029418955091387033,
0.015065021812915802,
-0.014448325149714947,
0.019721711054444313,
-0.020199965685606003,
0.004118653479963541,
0.013428887352347374,
0.06307927519083023,
0.06111590936779976,
-0.03589427098631859,
-0.000038863105146447197,
-0.006878057029098272,
-0.02293105237185955,
0.01738078147172928,
0.0018280654912814498,
-0.006588587071746588,
-0.032294776290655136,
0.035441186279058456,
-0.0007374403649009764,
0.07229197025299072,
-0.03028107061982155,
0.0027782819233834743,
0.037832461297512054,
0.030985867604613304,
0.014976922422647476,
0.014989507384598255,
-0.02416444569826126,
-0.04500627890229225,
0.0009313379996456206,
0.009785342030227184,
0.0016251219203695655,
-0.05849809572100639,
-0.07244299352169037,
-0.007601731922477484,
0.0019822397734969854,
0.01580757461488247,
0.01244091335684061,
0.001040675793774426,
-0.008174378424882889,
0.02922387607395649,
-0.01957068406045437,
-0.02977764420211315,
-0.007035377901047468,
0.007784223649650812,
-0.03586909919977188,
0.0011869840091094375,
0.000767331279348582,
-0.034962933510541916,
-0.0041595567017793655,
0.04213675111532211,
-0.0045497119426727295,
0.03166549280285835,
0.007715002633631229,
0.0160844586789608,
-0.023698776960372925,
-0.01857641711831093,
-0.00451824814081192,
0.006352606229484081,
0.0010524748358875513,
-0.03624666854739189,
0.006651515606790781,
-0.03513913229107857,
-0.011994123458862305,
0.005732763092964888,
-0.015794988721609116,
-0.012088515795767307,
0.04616415873169899,
-0.011515868827700615,
0.004600054584443569,
0.021131305024027824,
-0.006003354676067829,
-0.029173534363508224,
-0.0021584387868642807,
0.04636552929878235,
0.010238424874842167,
-0.029525931924581528,
0.04885748773813248,
-0.007645781617611647,
-0.014460910111665726,
-0.022943638265132904,
-0.0014379103668034077,
-0.012742969207465649,
-0.0054999287240207195,
0.01531673502177,
0.037832461297512054,
0.017745764926075935,
-0.02809116803109646,
-0.025372667238116264,
-0.00857082661241293,
0.018589003011584282,
-0.04143195599317551,
-0.05016639456152916,
-0.01038315985351801,
0.008526776917278767,
0.02902250550687313,
0.01879037357866764,
0.004980770405381918,
0.013856799341738224,
-0.009256744757294655,
0.0006446212064474821,
0.01032023224979639,
-0.009898613207042217,
-0.008073694072663784,
0.007243040949106216,
-0.009275623597204685,
0.028519080951809883,
0.024139273911714554,
-0.05985734611749649,
-0.009363722987473011,
-0.046969641000032425,
0.014674866572022438,
-0.01950775645673275,
-0.013063903898000717,
-0.013529572635889053,
-0.004801425151526928,
-0.0019193114712834358,
0.03282337263226509,
0.01857641711831093,
0.014498667791485786,
-0.003744230605661869,
-0.008098864927887917,
0.02504544146358967,
-0.017204582691192627,
0.0037694016937166452,
0.043168775737285614,
0.0008550375350750983,
-0.01980981044471264,
-0.01652495749294758,
-0.0026241077575832605,
0.012535306625068188,
0.010213254019618034,
-0.01089917216449976,
0.011937487870454788,
-0.0025533135049045086,
0.02074114978313446,
0.015379662625491619,
-0.001628268277272582,
-0.017972307279706,
-0.020715977996587753,
-0.012654869817197323,
0.00043892450048588216,
-0.009313380345702171,
0.026052292436361313,
-0.011799045838415623,
0.003807158675044775,
0.03128792345523834,
-0.08477693051099777,
-0.011710946448147297,
-0.013542158529162407,
0.00009930863598128781,
-0.026681575924158096,
0.021408189088106155,
-0.022100400179624557,
-0.022780023515224457,
-0.0007618250674568117,
-0.01950775645673275,
0.01871486008167267,
-0.019293799996376038,
0.006434413138777018,
-0.007305969018489122,
0.015455177053809166,
-0.022817781195044518,
-0.022767439484596252,
-0.013504400849342346,
-0.014863651245832443,
0.01389455609023571,
0.0032722686883062124,
0.021269746124744415,
-0.03365402668714523,
0.02066563442349434,
-0.006538244429975748,
-0.03654872253537178,
-0.007759052328765392,
-0.00716123403981328,
-0.05492377281188965,
-0.03846174106001854,
0.010339110158383846,
0.02028806507587433,
-0.026052292436361313,
0.04759892448782921,
-0.030331414192914963,
-0.032219260931015015,
0.011478112079203129,
0.005257654935121536,
0.019897909834980965,
-0.00852048397064209,
-0.024554600939154625,
0.02826736681163311,
0.02809116803109646,
0.007960422895848751,
-0.044402167201042175,
-0.015820160508155823,
-0.00407145731151104,
0.0024542014580219984,
0.003341489704325795,
-0.03589427098631859,
-0.040223732590675354,
-0.025410424917936325,
-0.004316877573728561,
0.00257533835247159,
0.005871205125004053,
-0.042111579328775406,
-0.01670115627348423,
0.04299257695674896,
0.016097044572234154,
0.012573063373565674,
-0.023975661024451256,
-0.0024416157975792885,
0.011975244618952274,
-0.023723948746919632,
-0.0172800961881876,
-0.011799045838415623,
-0.0016007372178137302,
0.040223732590675354,
-0.04427631199359894,
0.011283034458756447,
-0.011717239394783974,
-0.000232637845329009,
-0.03994685038924217,
0.04331980273127556,
0.0029167241882532835,
-0.013529572635889053,
-0.01158508937805891,
-0.0016502932412549853,
-0.008854003623127937,
0.019193114712834358,
-0.025674723088741302,
-0.017481466755270958,
-0.017204582691192627,
0.007060548756271601,
-0.012912875972688198,
-0.016512371599674225,
-0.018010063096880913,
0.015870502218604088,
0.01785903610289097,
-0.003659277455881238,
0.017984891310334206,
-0.017708007246255875,
-0.02344706282019615,
0.014825894497334957,
0.009093130938708782,
-0.029198704287409782,
-0.0164242722094059,
-0.009370015934109688,
0.003992796875536442,
-0.018198847770690918,
0.016550127416849136,
-0.016336172819137573,
0.005232483614236116,
-0.03571807220578194,
-0.0014158855192363262,
-0.026429861783981323,
0.003410710720345378,
-0.013869385235011578,
0.018639346584677696,
0.009458115324378014,
0.035642556846141815,
-0.014976922422647476,
0.03428330644965172,
-0.0014308309182524681,
0.016474613919854164,
0.015543276444077492,
0.0396951362490654,
-0.019633611664175987,
0.00987344142049551,
0.007595438975840807,
0.05975665897130966,
0.02902250550687313,
-0.02087959088385105,
-0.04805200546979904,
0.003310025669634342,
0.00590266939252615,
0.028695279732346535,
0.05074533447623253,
-0.0017336731543764472,
0.001420605112798512,
0.01178645994514227,
0.04976365342736244,
-0.009653192944824696,
-0.020715977996587753,
-0.01259194128215313,
0.001705355360172689,
-0.00203572865575552,
0.03166549280285835,
0.017267510294914246,
0.013353372924029827,
0.01153474673628807,
-0.01249125599861145,
-0.006047404371201992,
-0.016751497983932495,
0.043168775737285614,
0.001200356287881732,
-0.035164304077625275,
0.01163543201982975,
0.0047982786782085896,
0.007910080254077911,
0.011037614196538925,
0.027914969250559807,
0.03883931040763855,
0.06519366055727005,
0.004379805643111467,
0.027562571689486504,
0.011509575881063938,
-0.022968808189034462,
-0.01336595881730318,
0.038965169340372086,
-0.04679344221949577,
0.04339531809091568,
-0.010288767516613007,
-0.03654872253537178,
-0.0027232198044657707,
-0.02382463403046131,
-0.01892881654202938,
-0.011666896753013134,
0.015002093277871609,
0.0032974400091916323,
0.005650956183671951,
-0.0557795949280262,
0.043722543865442276,
-0.02460494264960289,
-0.016675984486937523,
0.010546773672103882,
0.02502026967704296,
-0.003347782650962472,
0.027537399902939796,
0.048479918390512466,
0.02064046449959278,
0.0013946471735835075,
0.0026744503993541002,
0.03254648670554161,
0.025372667238116264,
-0.039544109255075455,
-0.01298838946968317,
-0.0031479853205382824,
0.0065760016441345215,
-0.004892671015113592,
-0.0018013209337368608,
-0.004090335685759783,
0.023006565868854523,
0.06197173520922661,
0.034308478236198425,
-0.029450418427586555,
-0.009206402115523815,
0.04170884191989899,
-0.025108369067311287,
-0.03498810529708862,
-0.05386657640337944,
0.039342738687992096,
0.03294922783970833,
-0.012950632721185684,
-0.02374911867082119,
-0.01115717738866806,
0.01933155581355095,
-0.052759040147066116,
-0.03161514922976494,
0.09459373354911804,
-0.005886937025934458,
0.03405676409602165,
-0.03237028792500496,
0.002180463634431362,
0.019621025770902634,
0.0032533903140574694,
-0.006903228349983692,
-0.003379246685653925,
-0.025825751945376396,
0.008759611286222935,
-0.04342048987746239,
-0.034686047583818436,
0.0005580948782153428,
0.01670115627348423,
0.01470003742724657,
0.019532926380634308,
0.02846873737871647,
0.004883231595158577,
-0.013428887352347374,
-0.007016499061137438,
0.0028962723445147276,
0.037454891949892044,
0.01527897734194994,
0.006384070497006178,
0.001414312282577157,
0.0015370224136859179,
0.012466085143387318,
-0.030784497037529945,
-0.0058397408574819565,
-0.03481190279126167,
0.04331980273127556,
0.04739755392074585,
-0.020011181011795998,
-0.021131305024027824,
-0.016336172819137573,
-0.007444411050528288,
0.03682560846209526,
-0.01042091753333807,
-0.024139273911714554,
-0.04024890437722206,
0.008275063708424568,
0.0069158137775957584,
-0.0033194648567587137,
0.029752474278211594,
0.016713742166757584,
-0.0013545304536819458,
0.00903649628162384,
-0.0047007398679852486,
0.032873716205358505,
-0.003977064974606037,
-0.003914136905223131,
-0.013403715565800667,
-0.0112075200304389,
0.02426513098180294,
-0.007570267654955387,
0.019797226414084435,
-0.008841418661177158,
-0.032118577510118484,
0.002211927669122815,
0.00555341737344861,
-0.009615435265004635,
0.0031243872363120317,
-0.0468941256403923,
0.01485106535255909,
0.008614876307547092,
0.0008739159675315022,
0.013630257919430733,
-0.039644792675971985,
-0.0244665015488863,
-0.012692626565694809,
0.0043892450630664825,
0.009300794452428818,
-0.010395745746791363,
-0.004307438153773546,
0.021244574338197708,
0.023396721109747887,
-0.028770793229341507,
-0.020338408648967743,
0.014976922422647476,
-0.032521314918994904,
0.016675984486937523,
0.02761291339993477,
0.013680600561201572,
0.006569708697497845,
-0.009061667136847973,
-0.02398824691772461,
-0.00542441476136446,
-0.030205557122826576,
0.004357780795544386,
-0.012698919512331486,
-0.01427212543785572,
0.012201786041259766,
-0.0015834319638088346,
-0.0152286347001791,
0.0034673463087528944,
-0.007683538366109133,
-0.003225072519853711,
-0.03179134801030159,
0.019394485279917717,
-0.018022648990154266,
-0.04978882521390915,
0.013756114058196545,
-0.003517688950523734,
-0.0009132461273111403,
-0.0007209216710180044,
-0.01895398646593094,
-0.007274505216628313,
0.02741154283285141,
0.0013285725144669414,
0.0008691963739693165,
0.0037064736243337393,
-0.004886378068476915,
-0.027839455753564835,
-0.008325406350195408,
-0.004751082509756088,
0.0076080248691141605,
-0.01588308811187744,
-0.029047677293419838,
-0.03911619633436203,
-0.003907843958586454,
0.008300235494971275,
-0.010559359565377235,
0.007853444665670395,
-0.0039267223328351974,
0.03272268548607826,
-0.004386098589748144,
-0.019998595118522644,
-0.007249333895742893,
0.038965169340372086,
-0.008677804842591286,
0.01037057489156723,
-0.018198847770690918,
0.02494475618004799,
0.02018737979233265,
0.004880085121840239,
-0.010232132859528065,
0.00014001534145791084,
-0.010156618431210518,
-0.010968392714858055,
-0.021471116691827774,
0.05960563197731972,
-0.03476156294345856,
-0.03065863996744156,
0.02566213719546795,
0.007092013023793697,
-0.008186964318156242,
0.017682837322354317,
0.03476156294345856,
0.00009213088196702302,
0.0025957899633795023,
-0.0041406783275306225,
0.03617115318775177,
0.03141377866268158,
-0.015115364454686642,
-0.007022792007774115,
0.010892879217863083,
-0.03486224636435509,
0.01067892275750637,
0.006865471601486206,
0.023963075131177902,
-0.0012617112370207906,
0.009552507661283016,
-0.016751497983932495,
0.0019350434886291623,
-0.023019151762127876,
0.011031321249902248,
0.039921678602695465,
-0.00032978333183564246,
0.0014111659256741405,
0.033351968973875046,
-0.0314892940223217,
0.014498667791485786,
0.0020152770448476076,
-0.005824008956551552,
-0.005984475836157799,
-0.03486224636435509,
-0.012742969207465649,
-0.01313941739499569,
0.018878472968935966,
0.006009647157043219,
0.022289184853434563,
0.008577119559049606,
0.015027265064418316,
0.02283036708831787,
-0.018060406669974327,
0.0019303238950669765,
-0.0077338810078799725,
0.017544394358992577,
-0.010722972452640533,
0.015341905876994133,
-0.03131309524178505,
-0.028015654534101486,
0.03272268548607826,
0.002076632110401988,
0.005081455688923597,
0.014888822101056576,
-0.007658367510885,
0.021534044295549393,
0.002452628221362829,
0.006519366055727005,
-0.004052578937262297,
-0.0017855889163911343,
-0.04493076726794243,
0.030406927689909935,
-0.01821143366396427,
-0.002743671415373683,
0.0057233236730098724,
-0.02261641062796116,
-0.03987133502960205,
-0.007513632532209158,
-0.011528454720973969,
-0.030583126470446587,
0.016436858102679253,
0.001034382963553071,
-0.02460494264960289,
-0.011931194923818111,
0.011358547955751419,
-0.004165849648416042,
0.007658367510885,
0.01062858011573553,
0.034409165382385254,
-0.005610052961856127,
0.009917491115629673,
0.00391728337854147,
-0.015694303438067436,
0.0015708463033661246,
-0.0069158137775957584,
-0.006377777550369501,
-0.02806599624454975,
0.0009808939648792148,
-0.005002795252948999,
0.029928673058748245,
0.0010847256053239107,
0.019344141706824303,
0.011541039682924747,
-0.02337154932320118,
-0.006506780628114939,
0.018400218337774277,
0.04603830352425575,
-0.0016440004110336304,
0.008224721066653728,
0.01649978570640087,
-0.031640321016311646,
-0.022981394082307816,
-0.03989650681614876,
0.010634873062372208,
-0.024214787408709526,
-0.004065164364874363,
0.02645503357052803,
0.03536567464470863,
-0.005773666314780712,
-0.016210315749049187,
-0.002457347931340337,
0.0013505974784493446,
0.03131309524178505,
0.004143824800848961,
-0.007677245885133743,
0.013277859427034855,
-0.0160844586789608,
-0.025146126747131348,
0.023245694115757942,
0.029903501272201538,
0.00946440827101469,
-0.010609702207148075,
-0.009099423885345459,
-0.012050759047269821,
0.0005726470262743533,
0.030381755903363228,
-0.00999300554394722,
-0.0019885324873030186,
-0.04143195599317551,
0.03886448219418526,
-0.008646341040730476,
-0.013932312838733196,
0.01943224109709263,
0.013152003288269043,
0.006865471601486206,
-0.015543276444077492,
0.03166549280285835,
0.012308764271438122,
-0.012308764271438122,
0.011515868827700615,
-0.020690806210041046,
0.0029230169020593166,
-0.024214787408709526,
0.006588587071746588,
-0.023145008832216263,
-0.022364698350429535,
-0.008048522286117077,
0.029349733144044876,
-0.03715283423662186,
-0.005591174587607384,
-0.02012445218861103,
-0.01394489873200655,
-0.00317787635140121,
0.0030001041013747454,
-0.04938608407974243,
-0.03876379877328873,
-0.010817364789545536,
0.014762965962290764,
-0.02303173765540123,
-0.008514191024005413,
-0.03911619633436203,
0.03826037049293518,
0.04679344221949577,
0.0005592747475020587,
-0.012963218614459038,
0.05336315184831619,
0.009168645367026329,
-0.0038543548434972763,
0.009527335874736309,
0.015442591160535812,
0.025926437228918076,
-0.01950775645673275,
-0.04065164551138878,
-0.007469582371413708,
0.004326316993683577,
0.03644803911447525,
-0.016613056883215904,
0.00003901059608324431,
0.03083483874797821,
-0.01404558401554823,
0.02655571885406971,
-0.02436581626534462,
0.0004283053567633033,
-0.0032785614021122456,
0.006645222660154104,
-0.002756257075816393,
-0.014712623320519924,
-0.013680600561201572,
-0.011415183544158936,
0.01432246807962656,
0.006481609307229519,
-0.01807299256324768,
0.008350578136742115,
-0.00899873860180378,
0.05280938372015953,
0.002644559368491173,
0.010509016923606396,
0.03566772863268852,
0.04432665556669235,
-0.028821134939789772,
-0.016298415139317513,
0.01074814423918724,
-0.015102778561413288,
-0.016915112733840942,
-0.0014544290024787188,
0.036775264889001846,
-0.009659485891461372,
0.021773172542452812,
-0.004439587704837322,
0.00036006755544804037,
0.009300794452428818,
0.010106275789439678,
0.008809953927993774,
0.004732204135507345,
-0.008073694072663784,
0.01738078147172928,
-0.03994685038924217,
0.011874559335410595,
-0.043546345084905624,
-0.01590825989842415,
0.017191996797919273,
-0.004489930346608162,
-0.05396726354956627,
0.01809816248714924,
0.00046802882570773363,
-0.0031574247404932976,
0.019419655203819275,
0.0007158087682910264,
-0.015216049738228321,
-0.010817364789545536,
-0.04626484587788582,
0.026480205357074738,
0.011729824356734753,
-0.03753040358424187,
-0.013214930891990662,
-0.02478114329278469,
0.02420220337808132,
0.015933431684970856,
-0.025624381378293037,
-0.025951607152819633,
0.0054653179831802845,
-0.006277092266827822,
0.032521314918994904,
0.013957484625279903,
-0.006289678160101175,
-0.013680600561201572,
-0.030860010534524918,
0.006104039493948221,
0.004373513162136078,
0.03053278475999832,
-0.008029644377529621,
0.0054653179831802845,
0.014158855192363262,
0.00042751876753754914,
-0.01823660545051098,
-0.025095783174037933,
-0.02854425087571144,
0.02799048274755478,
-0.008747026324272156,
-0.0011625993065536022,
-0.004121799953281879,
0.014838479459285736,
0.01160396821796894,
0.033351968973875046,
-0.04712066799402237,
0.004593761637806892,
0.01336595881730318,
-0.0017619908321648836,
0.009766463190317154,
0.029903501272201538,
-0.013164588250219822,
0.01765766553580761,
-0.028292538598179817,
0.009621728211641312,
-0.007230455055832863,
-0.031187238171696663,
0.0376562625169754,
0.004961892031133175,
-0.0383358858525753,
-0.004974477458745241,
0.009105716831982136,
-0.026052292436361313,
-0.030155213549733162,
-0.03675009310245514,
-0.011138299480080605,
0.005339461378753185,
-0.01950775645673275,
0.00512550538405776,
-0.0017494051717221737,
0.010622287169098854,
-0.016688570380210876,
-0.0029623471200466156,
-0.01731785200536251,
0.016776669770479202,
-0.015140535309910774,
-0.0595552884042263,
-0.01389455609023571,
-0.029576275497674942,
-0.041054386645555496,
0.02016220986843109,
0.012717798352241516,
0.0236106775701046,
0.02152146026492119,
0.03581875562667847,
-0.010131447575986385,
0.02313242293894291,
-0.018664516508579254,
-0.012428328394889832,
0.04143195599317551,
0.0033131721429526806,
0.010458674281835556,
0.053916919976472855,
0.015530690550804138,
-0.0054653179831802845,
0.010439795441925526,
0.008809953927993774,
-0.0017462588148191571,
0.012371692806482315,
-0.029953844845294952,
-0.003423296380788088,
-0.010395745746791363,
0.005619492381811142,
0.07601732015609741,
-0.013768699951469898,
-0.009986712597310543,
0.012107393704354763,
-0.027336029335856438,
-0.016348756849765778,
0.005556563846766949,
-0.02237728424370289,
-0.004404976963996887,
-0.028242195025086403,
0.011906024068593979,
0.01960843987762928,
0.03103620931506157,
0.053715549409389496,
0.019696541130542755,
-0.01030135340988636,
0.014448325149714947,
0.042967405170202255,
-0.019696541130542755,
-0.027361201122403145,
-0.00557858869433403,
0.010194375179708004,
-0.004883231595158577,
0.03262200206518173,
-0.03740454837679863,
-0.01356732938438654,
0.0011995696695521474,
-0.0066389297135174274,
-0.018437976017594337,
-0.015719475224614143,
0.013579915277659893,
-0.01033281721174717,
0.04047544673085213,
-0.027159830555319786,
0.023220522329211235,
0.011868266388773918,
-0.010074811987578869,
-0.01512794941663742,
-0.010238424874842167,
0.015555862337350845,
0.0019208845915272832,
0.0029749327804893255,
-0.008444970473647118,
-0.0023063202388584614,
-0.010565652512013912,
0.014549010433256626,
-0.008759611286222935,
0.017972307279706,
0.01892881654202938,
-0.010263596661388874,
0.0118053387850523,
-0.00041965272976085544,
0.03367919474840164,
0.009583971463143826,
-0.010704094544053078,
-0.004338902421295643,
0.02004893869161606,
0.006387216970324516,
-0.0013679027324542403,
-0.02553628198802471,
-0.020854420959949493,
0.018123334273695946,
0.02809116803109646,
-0.011742410250008106,
0.03133826702833176
] | 2025-01-17 | 1 | 39818472 | [
"chimeric antigen receptor T cells",
"B cell maturation antigen",
"T cell engagers",
"resistance",
"BCMA)-targeted immunotherapeutic approaches",
"BCMA",
"great effectiveness",
"patients",
"MM",
"potential strategies",
"BCMA-targeted therapies",
"Multiple myeloma",
"BCMA-targeted immunotherapies",
"considerable uncertainty",
"the anti-MM activity",
"relapsed/refractory MM",
"TCEs",
"antigen-dependency, T cell-driven factors",
"long-term survival",
"antibody-drug conjugates",
"ADCs",
"the current understanding",
"CAR-T",
"both laboratory research and clinical practice",
"these novel therapies",
"their resistance",
"the relapse/refractory dilemma",
"the mechanisms",
"our understanding",
"(MM"
] | [
"Antibody-drug conjugates",
"B cell maturation antigen",
"Bispecific T cell engagers",
"Chimeric antigen receptor T cells",
"Multiple myeloma",
"Resistance mechanism"
] | 0 | 10.1016/j.blre.2025.101256 | [
"Yue",
"Sun",
"Dai",
"Jin"
] | [
"Department of Hematology, First Hospital of Jilin University, Changchun, Jilin, China; Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, Jilin, China.",
"Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, Jilin, China. Electronic address: [email protected].",
"Laboratory of Cancer Precision Medicine, First Hospital of Jilin University, Changchun, Jilin, China. Electronic address: [email protected].",
"Department of Hematology, First Hospital of Jilin University, Changchun, Jilin, China. Electronic address: [email protected]."
] | [
"39818472"
] | [] | 4.816514 | 6.246012 |
39818091 | 22 | PD1-TLR10 fusion protein enhances the antitumor efficacy of CAR-T cells in colon cancer. | The immunosuppressive microenvironment negatively affects the efficacy of chimeric antigen receptor T (CAR-T) cells in solid tumors. Fusion protein that combining extracellular domain of inhibitory checkpoint protein and the cytoplasmic domain of stimulatory molecule may improve the efficacy of CAR-T cells by reversing the suppressive signals.
To generate optimal PD1-TLR10 fusion proteins, PD1 extracellular domain and TLR10 intracellular domain were connected by transmembrane domain from PD1, CD28, or TLR10, respectively. The fusion protein was co-expressed with second generation anti-CEA CAR in the same retroviral vector. The effector function and the efficacy of fusion protein armored CAR-T cells was evaluated in vitro and in vivo.
PD1-TLR10 armored CEA CAR-T cells showed stronger cytotoxicity and cytokine release against CEA-positive tumor cells. Specifically, CAR-T cells with fusion protein containing TLR10 transmembrane domain demonstrated better anti-tumor activity in xenograft mouse model.
Our study demonstrated that CEA CAR-T armored with rational designed PD1-TLR10 fusion protein had improved efficacy in colon cancer. | [
0.04859326034784317,
-0.026751771569252014,
0.04210798442363739,
0.07884245365858078,
-0.011881955899298191,
0.00598151097074151,
0.00458022765815258,
0.02985543943941593,
0.014128641225397587,
0.001595262554474175,
-0.0014374734601005912,
-0.03687343746423721,
-0.052669722586870193,
-0.02116980031132698,
0.01667642965912819,
-0.028095150366425514,
0.05053884536027908,
-0.005691989324986935,
0.01879572495818138,
0.04553591459989548,
0.007400165311992168,
-0.010133246891200542,
-0.01279684342443943,
0.00907938927412033,
-0.051465313881635666,
0.00010576576460152864,
0.024597732350230217,
0.010660175234079361,
0.007122224662452936,
-0.009861096739768982,
0.032356902956962585,
-0.010457511059939861,
-0.0376146137714386,
-0.031801022589206696,
-0.05776529759168625,
0.027076035737991333,
0.04741201549768448,
0.004869748838245869,
-0.021783584728837013,
0.004319658502936363,
0.04312709718942642,
0.02441243827342987,
-0.008349794894456863,
0.08236303180456161,
-0.04347452521324158,
-0.03467307612299919,
0.014742426574230194,
-0.0268675796687603,
0.026728609576821327,
0.005616713780909777,
-0.024296630173921585,
0.023242773488163948,
-0.017324956133961678,
0.04951972886919975,
-0.03548373654484749,
0.00317894434556365,
-0.012507321313023567,
0.022084686905145645,
-0.025153614580631256,
0.04132048413157463,
-0.004533904138952494,
0.0008938971441239119,
0.046022310853004456,
-0.033144403249025345,
-0.025570524856448174,
-0.013329562731087208,
-0.05609765276312828,
-0.015228821896016598,
0.03279697522521019,
-0.013978090137243271,
0.004788682796061039,
0.00913150329142809,
-0.001967297401279211,
0.03634071722626686,
0.0510484017431736,
-0.023045897483825684,
0.02062550000846386,
0.024667218327522278,
0.0019557166378945112,
-0.013815958052873611,
0.013781215995550156,
0.000016274265362881124,
0.024759864434599876,
-0.02363652177155018,
-0.022547921165823936,
-0.04516533017158508,
-0.01730179414153099,
-0.043335553258657455,
-0.054152071475982666,
-0.0014953777426853776,
0.00006713275797665119,
0.012507321313023567,
-0.06605719029903412,
0.04125100001692772,
-0.007238033227622509,
0.03682711347937584,
-0.010787565261125565,
-0.06031308323144913,
0.020335977897047997,
0.04403040558099747,
0.02401868999004364,
-0.02661280147731304,
-0.03666498139500618,
-0.009415233507752419,
-0.0028648136649280787,
-0.006346307694911957,
-0.024597732350230217,
-0.012553645297884941,
-0.011939859949052334,
-0.022096268832683563,
0.10839679092168808,
-0.015078270807862282,
-0.04488738626241684,
0.0537351593375206,
-0.009392072446644306,
-0.048546936362981796,
-0.019224217161536217,
0.007319099269807339,
0.0011595329269766808,
0.04196901246905327,
-0.022814281284809113,
0.023995527997612953,
0.017973484471440315,
-0.016769075766205788,
-0.019803259521722794,
-0.008598783984780312,
0.06137852370738983,
-0.0361785851418972,
-0.04233960062265396,
-0.049890317022800446,
0.05331825092434883,
0.004710512235760689,
0.03990761935710907,
0.014904558658599854,
-0.04275651276111603,
-0.018147196620702744,
-0.028002504259347916,
-0.012206219136714935,
-0.03221793472766876,
-0.004959500394761562,
0.02339332364499569,
-0.030063895508646965,
-0.014232869260013103,
-0.031106172129511833,
-0.03351499140262604,
-0.058969706296920776,
-0.0043891435489058495,
-0.026751771569252014,
-0.0022466855589300394,
0.05280869081616402,
-0.03754512593150139,
0.025176774710416794,
0.04653187096118927,
0.0010705051245167851,
-0.0016792237292975187,
-0.023242773488163948,
-0.007562297396361828,
0.057950589805841446,
-0.024551410228013992,
-0.04951972886919975,
-0.01903892308473587,
-0.016803817823529243,
-0.03837894648313522,
-0.009172036312520504,
0.036688145250082016,
-0.002520283218473196,
-0.02031281776726246,
0.014163384214043617,
-0.09065491706132889,
-0.013572759926319122,
-0.01292423252016306,
-0.035993292927742004,
-0.06851232796907425,
0.0011913803173229098,
-0.061517491936683655,
0.011534529738128185,
-0.002374074887484312,
-0.004070669878274202,
0.004050403367727995,
-0.028303606435656548,
-0.003254219889640808,
0.009235730394721031,
0.017510250210762024,
0.013155849650502205,
-0.01754499226808548,
0.04210798442363739,
-0.013688568957149982,
0.06471380591392517,
-0.048546936362981796,
-0.0100753428414464,
-0.0006155947339721024,
0.010596481151878834,
0.05137266591191292,
-0.00414594542235136,
-0.04164474830031395,
-0.016479553654789925,
0.013954928144812584,
0.028025666251778603,
0.013410627841949463,
-0.031152496114373207,
0.02899845689535141,
-0.015749961137771606,
-0.055032216012477875,
0.010596481151878834,
0.012854747474193573,
-0.01551834400743246,
-0.02118138037621975,
0.037081893533468246,
-0.01572679914534092,
0.023740749806165695,
0.07027261704206467,
0.03247271478176117,
-0.0025767399929463863,
-0.016572201624512672,
0.0004082250816281885,
-0.019930649548768997,
0.009542623534798622,
0.02851206064224243,
0.03446462005376816,
0.01319059170782566,
-0.015425696969032288,
-0.003332390682771802,
0.019629547372460365,
-0.005214279051870108,
-0.044377829879522324,
0.0031210400629788637,
0.006375259719789028,
-0.01849462278187275,
0.004449943080544472,
-0.02203836478292942,
-0.03854107856750488,
-0.01620161347091198,
0.0038361577317118645,
-0.030619775876402855,
-0.022571083158254623,
-0.010897583328187466,
0.04840796813368797,
-0.0023494656197726727,
0.07115276157855988,
-0.009924791753292084,
-0.013016879558563232,
0.03506682440638542,
-0.004736569244414568,
-0.0000677208518027328,
-0.04535062238574028,
0.012159896083176136,
-0.0018833363428711891,
-0.0762946605682373,
-0.015043528750538826,
-0.010133246891200542,
0.03418667986989021,
0.023370161652565002,
0.005031880922615528,
-0.020891860127449036,
0.014313935302197933,
0.02749294601380825,
0.038819022476673126,
-0.05280869081616402,
0.02709919773042202,
-0.002630301285535097,
0.0030718212947249413,
0.01414022222161293,
-0.0322410948574543,
-0.0388653427362442,
-0.015749961137771606,
0.0022408950608223677,
0.008176082745194435,
0.022571083158254623,
-0.006236289627850056,
-0.002667939057573676,
0.047620467841625214,
0.03620174899697304,
0.018992599099874496,
0.01184721291065216,
-0.04384510964155197,
0.03363079950213432,
-0.017799772322177887,
0.048639584332704544,
-0.008193453773856163,
0.01927053928375244,
-0.03168521448969841,
-0.00896358024328947,
-0.005312716588377953,
-0.006936931051313877,
-0.00012087515642633662,
-0.011459254659712315,
0.012379932217299938,
-0.0020179636776447296,
-0.010978649370372295,
-0.035367924720048904,
0.01039381604641676,
0.008037112653255463,
-0.02164461463689804,
-0.014950881712138653,
-0.017730286344885826,
0.02378707379102707,
0.0021670672576874495,
-0.017521832138299942,
-0.03817049413919449,
0.007822866551578045,
-0.010115875862538815,
0.01346853282302618,
-0.028581546619534492,
-0.01129133254289627,
0.029021618887782097,
-0.00778233353048563,
-0.01888837106525898,
-0.0254315547645092,
0.015842607244849205,
0.05141898989677429,
0.03263484686613083,
-0.03525211662054062,
0.028164636343717575,
0.03159256651997566,
-0.008928838185966015,
0.0026939960662275553,
0.01697753183543682,
-0.04453996196389198,
0.007266985718160868,
-0.037823066115379333,
-0.02070656605064869,
-0.010289588011801243,
-0.0368039533495903,
-0.015541505068540573,
0.03342234343290329,
0.0029791744891554117,
0.00780549505725503,
-0.021633034572005272,
0.006537391804158688,
-0.01975693553686142,
0.03603961691260338,
-0.025338906794786453,
0.05512486398220062,
-0.0017660801531746984,
0.004863958340138197,
-0.000927915854845196,
-0.030272351577878,
-0.03427932783961296,
0.017961904406547546,
0.02788669429719448,
0.0012652082368731499,
0.0281183123588562,
-0.05989617481827736,
0.06332410871982574,
0.03395506367087364,
0.016942787915468216,
0.021702518686652184,
0.015205660834908485,
0.015541505068540573,
0.044516801834106445,
-0.012426256202161312,
0.037081893533468246,
0.0009568679961375892,
-0.027052873745560646,
-0.006172595079988241,
0.008118178695440292,
-0.0349278524518013,
-0.060637347400188446,
-0.007156967651098967,
-0.0030226027593016624,
0.026844417676329613,
0.040810927748680115,
-0.026983387768268585,
0.024435600265860558,
0.022026782855391502,
0.04006975144147873,
-0.028465738520026207,
0.06550130993127823,
-0.014707683585584164,
-0.03705872967839241,
-0.020104361698031425,
0.010202731937170029,
0.026288537308573723,
0.012101992033421993,
-0.020752890035510063,
-0.003141306573525071,
-0.005512486211955547,
0.028396252542734146,
0.009646850638091564,
-0.014452905394136906,
0.03423300385475159,
-0.029762793332338333,
-0.016004739329218864,
0.02220049686729908,
0.005309821106493473,
0.01818194054067135,
0.03175469860434532,
-0.01628267951309681,
-0.060544703155756,
0.02503780461847782,
0.008668269030749798,
-0.030434483662247658,
0.008923047222197056,
-0.0020208589266985655,
-0.0308050699532032,
0.06457483768463135,
0.02425030618906021,
0.03958335891366005,
0.03562270477414131,
0.018772562965750694,
-0.009490509517490864,
-0.030202865600585938,
-0.009670012630522251,
-0.018228262662887573,
0.021285608410835266,
-0.02000013366341591,
0.043497685343027115,
-0.01047488208860159,
0.004299391992390156,
-0.001889126724563539,
0.006079948041588068,
0.002931403461843729,
0.024945158511400223,
0.029345883056521416,
0.004447047598659992,
-0.015333049930632114,
-0.0330517552793026,
0.015854189172387123,
-0.026960227638483047,
0.008123968727886677,
0.05577338859438896,
-0.02134351246058941,
0.021934136748313904,
0.010092713870108128,
0.027400299906730652,
0.001928212121129036,
0.052901338785886765,
0.03682711347937584,
0.020996088162064552,
-0.04178372025489807,
-0.005133213475346565,
0.053920455276966095,
0.0057991123758256435,
-0.029484853148460388,
0.0009612108115106821,
0.012750519439578056,
-0.02631169930100441,
0.03745248168706894,
-0.04938076063990593,
0.03066609986126423,
-0.0461149588227272,
-0.017406022176146507,
0.01319059170782566,
-0.06545498222112656,
0.010851259343326092,
-0.002375522628426552,
0.04076460376381874,
0.0031297255773097277,
-0.012623130343854427,
0.0282109584659338,
-0.004478895105421543,
0.011071295477449894,
-0.012426256202161312,
0.03610910102725029,
-0.031245142221450806,
0.017637640237808228,
-0.0037666726857423782,
-0.049102820456027985,
-0.0011059715179726481,
0.02575581893324852,
0.06476013362407684,
-0.063231460750103,
0.0014570161001756787,
-0.015761541202664375,
0.011024972423911095,
0.04122783988714218,
0.009629479609429836,
-0.019085247069597244,
0.014418162405490875,
-0.04180688038468361,
-0.03974548727273941,
0.011916697956621647,
-0.003341076197102666,
0.0240881759673357,
-0.020498109981417656,
0.02172568067908287,
0.00586859742179513,
0.00951367150992155,
0.04430834576487541,
0.007180129177868366,
-0.005217174533754587,
-0.014012833125889301,
-0.0015098537551239133,
-0.03462675213813782,
0.03546057268977165,
0.07949097454547882,
-0.014626617543399334,
-0.008129758760333061,
-0.044285181909799576,
0.017510250210762024,
0.02828044444322586,
-0.0020570491906255484,
0.03888850659132004,
-0.010770193301141262,
0.00713380565866828,
-0.015321468934416771,
0.02394920401275158,
-0.02473670244216919,
0.003074716543778777,
0.004950814880430698,
0.023497551679611206,
0.06392630934715271,
0.03149992227554321,
-0.014313935302197933,
0.03203263878822327,
0.07277408242225647,
0.015298306941986084,
0.043821949511766434,
0.0020541539415717125,
0.01887679100036621,
0.0037319299299269915,
-0.018772562965750694,
0.029206912964582443,
0.016803817823529243,
-0.017904000356793404,
-0.017093339934945107,
-0.053457219153642654,
-0.0089346282184124,
-0.000026984293072018772,
0.01209041103720665,
0.0032744864001870155,
-0.028419414535164833,
0.008448232896625996,
0.029693307355046272,
0.00008522784628439695,
-0.02853522263467312,
-0.02038230188190937,
-0.01708175800740719,
-0.04724988341331482,
-0.061749111860990524,
0.04138997197151184,
-0.023115383461117744,
0.005385096650570631,
0.01738286018371582,
-0.01363066490739584,
0.006792170461267233,
-0.015020366758108139,
0.02867419272661209,
-0.006079948041588068,
-0.021899394690990448,
0.009102551266551018,
-0.001218884834088385,
0.018274586647748947,
-0.004832111299037933,
0.008193453773856163,
0.025477876886725426,
-0.009687383659183979,
-0.005416944157332182,
0.0191199891269207,
-0.03974548727273941,
0.039791811257600784,
-0.033700283616781235,
-0.019096827134490013,
0.001254351227544248,
0.00963526964187622,
-0.007104853633791208,
-0.00033837807131931186,
-0.0403013713657856,
-0.0268675796687603,
-0.022455275058746338,
-0.021783584728837013,
0.008361375890672207,
0.023578617721796036,
-0.03300543129444122,
-0.010567529127001762,
0.02568633295595646,
-0.004858167842030525,
-0.01849462278187275,
-0.045003198087215424,
0.04845429211854935,
-0.027307651937007904,
-0.000995953450910747,
-0.026288537308573723,
-0.004510742612183094,
0.055032216012477875,
0.006873236503452063,
-0.012217800132930279,
0.02258266508579254,
0.0019050503615289927,
0.003601645352318883,
-0.02243211306631565,
-0.01620161347091198,
0.0012681034859269857,
0.06355572491884232,
-0.024597732350230217,
0.0027663763612508774,
-0.02347438968718052,
-0.0191199891269207,
-0.016572201624512672,
-0.01066596619784832,
-0.011048134416341782,
-0.007620201446115971,
0.018459880724549294,
0.008685640059411526,
0.0006981083424761891,
0.00829189084470272,
0.00781707651913166,
0.009108341298997402,
-0.042941804975271225,
-0.003737720428034663,
0.026358023285865784,
-0.02411133609712124,
-0.011030762456357479,
-0.0376146137714386,
-0.011650338768959045,
-0.001631452701985836,
0.03546057268977165,
0.013063202612102032,
-0.00951367150992155,
-0.0006680705118924379,
0.042223792523145676,
0.02441243827342987,
-0.004478895105421543,
0.02496832050383091,
0.002750452607870102,
0.013074783608317375,
-0.008413489907979965,
0.007898141629993916,
0.008245567791163921,
-0.01746392622590065,
-0.012136734090745449,
-0.013445370830595493,
-0.005804902873933315,
-0.0090446462854743,
-0.011754565872251987,
-0.034487780183553696,
-0.025477876886725426,
0.0007578220684081316,
0.03534476459026337,
0.02220049686729908,
0.030457643792033195,
-0.04060247167944908,
-0.004476000089198351,
0.061749111860990524,
0.011314493604004383,
-0.03416351601481438,
0.009021485224366188,
-0.02591794915497303,
-0.03400138393044472,
-0.008164501748979092,
-0.005500905215740204,
0.02053285390138626,
-0.00027558812871575356,
-0.011789308860898018,
0.015460439026355743,
0.006821122486144304,
-0.01627109944820404,
0.012217800132930279,
0.00022691235062666237,
-0.009733707644045353,
-0.005147689487785101,
-0.03147675842046738,
0.021864650771021843,
0.013642244972288609,
0.03423300385475159,
-0.019699031487107277,
-0.011719823814928532,
-0.0140591561794281,
0.021829908713698387,
0.05285501480102539,
-0.03381609171628952,
0.016259517520666122,
0.011395559646189213,
-0.01770712435245514,
-0.02788669429719448,
0.005298240575939417,
-0.008923047222197056,
0.010683337226510048,
0.010781774297356606,
-0.013109525665640831,
0.08393802493810654,
-0.008946209214627743,
-0.004927653353661299,
0.0102316839620471,
0.008170291781425476,
0.011447673663496971,
-0.0014599113492295146,
-0.017510250210762024,
-0.027446622028946877,
-0.002753347856923938,
-0.019791679456830025,
0.0394907109439373,
-0.018042970448732376,
-0.07226452231407166,
-0.003294752910733223,
-0.0036595496349036694,
-0.007597039919346571,
-0.011812470853328705,
0.012750519439578056,
-0.034557268023490906,
0.0005359763745218515,
-0.013734892010688782,
-0.00939786247909069,
0.009571575559675694,
-0.0023899986408650875,
0.020602338016033173,
-0.0090446462854743,
-0.009432605467736721,
0.024667218327522278,
0.0003371114144101739,
0.029832279309630394,
0.015425696969032288,
0.020197007805109024,
-0.01197460200637579,
0.04148261621594429,
-0.013746473006904125,
-0.021204542368650436,
-0.030758745968341827,
0.01856410875916481,
0.047527823597192764,
-0.004192268941551447,
-0.013086364604532719,
-0.018633592873811722,
-0.019467415288090706,
0.008430860936641693,
0.031083010137081146,
-0.013341142795979977,
0.04359033331274986,
0.029415367171168327,
0.006572134327143431,
0.02519993670284748,
-0.006363679189234972,
-0.008355585858225822,
-0.00006012091398588382,
0.011592434719204903,
0.008361375890672207,
-0.021748842671513557,
0.06624247878789902,
-0.019641127437353134,
0.012750519439578056,
-0.0205560140311718,
-0.044933710247278214,
-0.01335272379219532,
0.009409443475306034,
-0.028349928557872772,
0.002403027145192027,
-0.008529298938810825,
-0.006879027001559734,
-0.004588913172483444,
0.013364304788410664,
0.029646985232830048,
-0.03810100629925728,
-0.02890581078827381,
0.008703011088073254,
-0.013086364604532719,
0.03414035588502884,
-0.0004849482502322644,
0.014672941528260708,
0.003477151272818446,
-0.003700082655996084,
0.00015661295037716627,
0.007017997093498707,
0.0049189673736691475,
0.009374700486660004,
-0.022061524912714958,
-0.03288962319493294,
0.01251890230923891,
-0.0033439714461565018,
-0.012576807290315628,
0.03300543129444122,
-0.02203836478292942,
0.010052180849015713,
-0.013746473006904125,
-0.016085805371403694,
-0.04053298756480217,
0.012379932217299938,
0.007909722626209259,
0.01849462278187275,
-0.02971646934747696,
0.004617865197360516,
-0.02394920401275158,
-0.021146638318896294,
-0.008031321689486504,
-0.019733773544430733,
-0.02047494798898697,
0.026265375316143036,
-0.03508998453617096,
0.015379372984170914,
-0.0030457645189017057,
0.03249587491154671,
0.003115249564871192,
0.022791119292378426,
-0.012125153094530106,
-0.0007017273455858231,
0.008459813892841339,
-0.009467347525060177,
0.008245567791163921,
0.00243776966817677,
-0.022698473185300827,
-0.007950255647301674,
-0.01594683527946472,
0.029600661247968674,
-0.030040733516216278,
0.008465603925287724,
0.011401350609958172,
0.034812044352293015,
0.03735983371734619,
-0.09876152127981186,
-0.025616846978664398,
-0.008564040996134281,
-0.01951373741030693,
-0.00702957808971405,
0.0061436425894498825,
0.004554170649498701,
-0.020729728043079376,
0.017197567969560623,
-0.02654331550002098,
0.029670147225260735,
-0.015680475160479546,
0.023196449503302574,
-0.00705273961648345,
0.0015619676560163498,
-0.02640434540808201,
0.00027993094408884645,
-0.04308077320456505,
0.034325648099184036,
0.030295511707663536,
0.0002971212670672685,
0.016004739329218864,
0.03372344374656677,
0.0549858920276165,
0.006786379963159561,
0.01708175800740719,
-0.023034317418932915,
-0.025778979063034058,
-0.02559368684887886,
-0.0063578886911273,
0.016329003497958183,
0.010370654053986073,
0.007695476990193129,
0.024597732350230217,
-0.026983387768268585,
-0.04213114455342293,
0.02774772420525551,
-0.0026520155370235443,
-0.012820004485547543,
0.02148248255252838,
0.0026056920178234577,
0.00460338918492198,
0.002741767093539238,
0.020486529916524887,
-0.03342234343290329,
-0.012403094209730625,
-0.030087057501077652,
-0.01287790946662426,
0.005072413943707943,
-0.00592650193721056,
0.016688009724020958,
-0.03548373654484749,
-0.019421091303229332,
0.018274586647748947,
-0.0006354993092827499,
-0.009588946588337421,
-0.001563415164127946,
0.02045178785920143,
0.028419414535164833,
0.023659683763980865,
-0.03138411417603493,
0.03673446550965309,
0.028419414535164833,
-0.012947394512593746,
0.015703637152910233,
-0.020810794085264206,
-0.03460358828306198,
0.020092781633138657,
-0.04914914071559906,
0.011748775839805603,
0.012403094209730625,
-0.005509591195732355,
-0.0254315547645092,
0.01587734930217266,
-0.01762605831027031,
-0.011748775839805603,
0.007788124028593302,
0.009467347525060177,
0.00848876591771841,
0.02291850931942463,
0.023370161652565002,
-0.014661360532045364,
0.024690380319952965,
0.025338906794786453,
-0.01659536361694336,
-0.0164332315325737,
-0.013005298562347889,
0.021146638318896294,
-0.010689128190279007,
-0.028164636343717575,
0.018946276977658272,
-0.016861721873283386,
-0.04993664100766182,
0.006919560022652149,
0.002953117713332176,
0.0011276856530457735,
-0.005011614412069321,
0.01708175800740719,
0.00939786247909069,
-0.039467547088861465,
0.029508015140891075,
-0.057163093239068985,
-0.013804377056658268,
-0.02361335977911949,
-0.059525586664676666,
0.024759864434599876,
0.031175658106803894,
-0.005636980291455984,
0.006867446005344391,
-0.020810794085264206,
0.04766679182648659,
0.0031760490965098143,
0.014800330623984337,
-0.016340583562850952,
0.003824576735496521,
-0.000744069810025394,
0.006566343829035759,
-0.047435175627470016,
0.018124036490917206,
-0.00999427679926157,
0.05461530387401581,
0.032820139080286026,
-0.0102780070155859,
-0.008841981180012226,
0.020845536142587662,
0.00370297790504992,
-0.005558809731155634,
0.013097945600748062,
0.018853629007935524,
-0.008650897070765495,
0.0016618524678051472,
0.0047163027338683605,
0.005969929974526167,
0.00608573853969574,
-0.013769634999334812,
0.038749534636735916,
0.052669722586870193,
0.03791571408510208,
-0.003152887336909771,
0.02298799343407154,
-0.00600467249751091,
-0.022791119292378426,
0.005521171726286411,
-0.04118151590228081,
0.02473670244216919,
-0.015205660834908485,
-0.06059102341532707,
0.0021685147657990456,
0.005503800697624683,
0.011835631914436817,
-0.00995953381061554,
0.018425138667225838,
0.016398487612605095,
0.05322560295462608,
-0.003442408749833703,
0.055819712579250336,
0.026659125462174416,
-0.010243264958262444,
-0.013619083911180496,
-0.001260141609236598,
-0.028071988373994827,
0.0448642261326313,
-0.02203836478292942,
-0.012657872401177883,
0.032982271164655685,
-0.0164332315325737,
-0.017880838364362717,
0.0017269947566092014,
0.02156354859471321,
0.025941111147403717,
0.010671756230294704,
-0.02631169930100441,
0.048083703964948654,
-0.0018225368112325668,
-0.0180892925709486,
-0.02339332364499569,
0.007400165311992168,
0.01739444211125374,
0.029484853148460388,
0.046416059136390686,
-0.04203849658370018,
0.006444744765758514,
0.03453410416841507,
0.03729034960269928,
0.04678664728999138,
-0.010144827887415886,
0.046971943229436874,
-0.021910974755883217,
0.021992040798068047,
-0.021366674453020096,
0.0011233427794650197,
-0.030944040045142174,
0.005645666271448135,
0.040092915296554565,
0.027052873745560646,
-0.01209041103720665,
-0.005002928897738457,
0.014441324397921562,
-0.03682711347937584,
-0.036711305379867554,
0.00013897023745812476,
0.04296496510505676,
0.024203984066843987,
-0.03423300385475159,
-0.020972926169633865,
0.01682697981595993,
0.025778979063034058,
-0.06225866824388504,
0.0023856558836996555,
0.048778556287288666,
0.0018297748174518347,
0.022096268832683563,
0.007498602382838726,
0.0013122555101290345,
0.024921996518969536,
0.010000066831707954,
-0.02425030618906021,
0.01225254312157631,
-0.021459320560097694,
-0.021841488778591156,
-0.01872624084353447,
-0.035367924720048904,
0.010758613236248493,
-0.018865210935473442,
-0.006120481062680483,
0.020741308107972145,
0.042223792523145676,
0.022061524912714958,
-0.0016053958097472787,
0.032843299210071564,
-0.03837894648313522,
0.021633034572005272,
0.006305774673819542,
0.020671823993325233,
0.009270473383367062,
0.017174405977129936,
-0.021517226472496986,
-0.03562270477414131,
0.024875672534108162,
-0.0065779248252511024,
0.023416485637426376,
0.005697779823094606,
0.019571641460061073,
-0.03990761935710907,
-0.020880278199911118,
-0.00021895051759202033,
0.05554177239537239,
-0.04178372025489807,
0.008494555950164795,
-0.017243890091776848,
-0.03719770163297653,
0.0028344138991087675,
0.02661280147731304,
0.032125286757946014,
0.055263832211494446,
0.011007601395249367,
0.006456325761973858,
0.027539269998669624,
0.00983214471489191,
0.013653825968503952,
0.004001184832304716,
0.008674059063196182,
-0.009849515743553638,
-0.010034809820353985,
-0.0016850142274051905,
0.0035697980783879757,
-0.001708175870589912,
0.00697167357429862,
0.011401350609958172,
0.005477743688970804,
0.03585432097315788,
0.020521271973848343,
-0.007544925902038813,
0.007678105961531401,
0.015784703195095062,
0.01573837921023369,
0.017324956133961678,
0.01497404370456934,
0.005509591195732355,
0.011951440945267677,
-0.017741868272423744,
0.0103880250826478,
0.0038303672336041927,
0.01284316647797823,
0.01683856174349785,
0.02584846504032612,
-0.01761447824537754,
0.002308932598680258,
0.02876684069633484,
-0.04560540243983269,
-0.05271604657173157,
-0.014256030321121216,
0.009890048764646053,
-0.027307651937007904,
0.00719171017408371,
-0.03499734029173851,
-0.007550716400146484,
-0.010718080215156078,
-0.002112058224156499,
-0.047620467841625214,
0.014869815669953823,
0.02661280147731304,
-0.03610910102725029,
-0.01196302194148302,
0.01856410875916481,
-0.0510484017431736,
-0.0336771234869957,
-0.027238167822360992,
0.02054443396627903,
-0.007301728241145611,
-0.03231058269739151,
0.006774799432605505,
0.023810233920812607,
-0.010098503902554512,
0.02774772420525551,
0.012727358378469944,
-0.008419280871748924,
0.030944040045142174,
0.036618657410144806,
-0.000520052679348737,
0.005952558480203152,
0.023532293736934662,
0.01015061791986227,
-0.01327165775001049,
-0.007319099269807339,
0.007730219513177872,
0.009820563718676567,
-0.01952531933784485,
0.0033989804796874523,
-0.037081893533468246,
0.01165612880140543,
-0.03379293158650398,
0.02529258467257023,
-0.003812995972111821,
0.019791679456830025,
0.029832279309630394,
-0.010677547194063663,
-0.03126830607652664,
-0.013503274880349636,
0.007788124028593302,
-0.030758745968341827,
-0.009276263415813446,
0.01363066490739584,
0.002075867960229516,
-0.010804936289787292,
0.0073248897679150105,
-0.010492253117263317,
-0.020092781633138657,
-0.006716894917190075,
-0.012437836267054081,
0.04840796813368797,
-0.026751771569252014,
-0.028164636343717575,
0.04724988341331482,
0.015113013796508312,
0.007168548181653023,
0.004811844788491726,
0.010932325385510921,
0.007492812350392342,
-0.007996579632163048,
-0.006328936200588942,
0.01879572495818138,
0.01580786518752575,
-0.025941111147403717,
-0.0012731701135635376,
0.03254219889640808,
-0.022490017116069794,
0.007046949118375778,
-0.011424511671066284,
0.003639283124357462,
0.0012644844828173518,
0.023485971614718437,
-0.032194770872592926,
0.0141054792329669,
0.006161014083772898,
0.02369442582130432,
0.03451094403862953,
-0.00740595581009984,
-0.008824610151350498,
0.04868590831756592,
0.02378707379102707,
-0.024134498089551926,
0.007811285555362701,
-0.01817035861313343,
0.009473138488829136,
-0.011806679889559746,
-0.02654331550002098,
-0.014649779535830021,
0.03423300385475159,
-0.03166205435991287,
0.0014729398535564542,
-0.014093898236751556,
0.015425696969032288,
-0.009189407341182232,
-0.0017269947566092014,
0.0016777761047706008,
0.013954928144812584,
0.016329003497958183,
-0.022559503093361855,
0.0053445640951395035,
-0.029809117317199707,
-0.01841355673968792,
-0.009612108580768108,
-0.004033032339066267,
0.023740749806165695,
0.03603961691260338,
0.009890048764646053,
0.005124527495354414,
-0.0053966776467859745,
0.010897583328187466,
-0.0255242008715868,
-0.0076086209155619144,
-0.05971087887883186,
0.042640700936317444,
-0.043567169457674026,
-0.007064320612698793,
0.011216056533157825,
-0.010851259343326092,
-0.022710053250193596,
0.00008292072016047314,
-0.0060915290378034115,
-0.001112485770136118,
0.008957790210843086,
-0.027145519852638245,
-0.013769634999334812,
0.022547921165823936,
0.021227704361081123,
0.009415233507752419,
-0.06026676297187805,
0.03328337147831917,
-0.0029082419350743294,
0.006195756606757641,
0.0030834022909402847,
-0.009901629760861397,
-0.01928212121129036,
0.010689128190279007,
-0.021760422736406326,
0.014557132497429848,
-0.037244025617837906,
0.004056193865835667,
-0.0005895378417335451,
-0.014962462708353996,
0.043497685343027115,
0.02338174358010292,
-0.0019890116527676582,
-0.021204542368650436,
-0.0010871526319533587,
-0.017834514379501343,
0.005495115183293819,
0.030619775876402855,
0.009426814503967762,
-0.0005464715068228543,
0.001996249658986926,
0.0009532489930279553,
-0.034649912267923355,
-0.005162165500223637,
-0.023346999660134315,
-0.008841981180012226,
0.012356770224869251,
0.0006358612445183098,
-0.039073798805475235,
0.010683337226510048,
0.007741800509393215,
0.013607502914965153,
-0.006635828875005245,
0.0207760501652956,
0.012113573029637337,
0.023578617721796036,
-0.02370600774884224,
0.012322028167545795,
-0.0012782367412000895,
0.023810233920812607,
0.005393782630562782,
0.012623130343854427,
0.03414035588502884,
-0.01552992407232523,
0.02480618841946125,
-0.015680475160479546,
0.008621945045888424,
-0.006583715323358774,
-0.03879585862159729,
0.0034279325045645237,
0.014927719719707966,
-0.030156541615724564,
0.013885443098843098,
-0.0002849975717253983,
-0.01715124398469925,
-0.018112454563379288,
0.025223098695278168,
0.002929955953732133,
0.009808982722461224,
-0.008952000178396702,
-0.00565145630389452,
-0.00017380327335558832,
-0.009247311390936375,
-0.015680475160479546,
-0.002045468194410205,
0.004545485135167837,
-0.014927719719707966,
-0.006265241652727127,
0.006873236503452063,
-0.0011421616654843092,
0.01330640073865652,
0.01225254312157631,
0.010162198916077614,
-0.004059089347720146,
-0.03522895649075508,
-0.0535498671233654,
-0.0000659565776004456,
-0.01497404370456934,
-0.034024547785520554,
0.0008772496366873384,
-0.0007375556160695851,
0.030480805784463882,
0.034881532192230225,
-0.038749534636735916,
-0.019884325563907623,
0.0436134934425354,
0.0013621979160234332,
-0.008233986794948578,
0.007927094586193562,
0.010671756230294704,
0.008471393957734108,
-0.037568289786577225,
-0.011951440945267677,
-0.03191683068871498,
0.014128641225397587,
0.009820563718676567,
-0.044910550117492676,
-0.007342261262238026,
0.06684468686580658,
-0.005793321877717972,
-0.008448232896625996,
-0.0015330155147239566,
-0.005906235426664352,
0.0508631095290184,
-0.005298240575939417,
-0.029762793332338333,
-0.005367725621908903,
-0.029531177133321762,
-0.030874555930495262,
-0.0022466855589300394,
0.025385230779647827,
-0.005616713780909777,
0.021111896261572838,
0.04998296499252319,
0.005608028266578913,
-0.023671263828873634,
-0.013978090137243271,
0.014638198539614677,
0.014395000413060188,
-0.0053879921324551105,
0.007776543032377958,
-0.010972858406603336,
-0.01705859787762165,
-0.05276236683130264,
0.01015061791986227,
-0.02378707379102707,
-0.03895799070596695,
-0.013260076753795147,
0.010833888314664364,
0.027006549760699272,
0.023439647629857063,
0.0013137030182406306,
0.003228162880986929,
0.0016111861914396286,
0.009073598310351372,
-0.015205660834908485,
-0.020833956077694893,
-0.020671823993325233,
-0.011881955899298191,
-0.007637572940438986,
-0.00317894434556365,
0.012808423489332199,
-0.010706499218940735,
0.03610910102725029,
0.0019340025028213859,
0.007400165311992168,
-0.03154624626040459,
-0.014835073612630367,
0.007683896459639072,
0.01217147707939148,
-0.029994409531354904,
0.01565731316804886,
-0.022466855123639107,
-0.04574437066912651,
-0.03478888422250748,
0.03460358828306198,
-0.017348118126392365,
0.0025723970029503107,
-0.054476335644721985,
-0.015147755853831768,
0.030063895508646965,
-0.008731963112950325,
-0.007168548181653023,
0.0407414436340332,
-0.006473697256296873,
0.017672382295131683,
-0.04771311581134796,
-0.013283238746225834,
-0.04632341489195824,
0.02464405633509159,
0.005147689487785101,
-0.02702971175312996,
-0.016166871413588524,
0.01197460200637579,
-0.004449943080544472,
-0.009357329457998276,
-0.02306905947625637,
-0.014256030321121216,
-0.009339958429336548,
0.0078576086089015,
-0.02506096661090851,
-0.004713407251983881,
0.01493930071592331,
0.026798095554113388,
-0.036155425012111664,
-0.004128574393689632,
0.015124594792723656,
0.019015761092305183,
0.02624221332371235,
0.03893483057618141,
0.006056786514818668,
0.01200934499502182,
-0.0008381642401218414,
-0.006108900066465139,
-0.004771311767399311,
0.0009648298728279769,
0.04370614141225815,
-0.034418296068906784,
0.010353283025324345,
0.04687929525971413,
0.03562270477414131,
-0.005758579354733229,
0.03381609171628952,
-0.025014642626047134,
-0.029021618887782097,
-0.009687383659183979,
-0.02110031433403492,
-0.007243823725730181,
0.01173719484359026,
0.0022510283160954714,
0.010694918222725391,
0.019699031487107277,
-0.019258959218859673,
0.019710613414645195,
-0.006902188528329134,
-0.0011711138067767024,
0.0061668045818805695,
0.0057991123758256435,
-0.009687383659183979,
0.013456951826810837,
0.004742359276860952,
0.028813162818551064,
0.011470835655927658,
0.008355585858225822,
0.011372397653758526,
0.019930649548768997,
-0.008095016703009605,
0.008575621992349625,
0.008743544109165668,
-0.005026090424507856,
-0.0004860339395236224,
0.01351485587656498,
0.023902881890535355,
0.009531042538583279,
0.021517226472496986,
0.007058530114591122,
-0.008894095197319984,
-0.0057875313796103,
-0.04604547470808029,
-0.009432605467736721,
-0.027307651937007904,
0.0014866921119391918,
0.12442468851804733,
-0.015066690742969513,
0.01770712435245514,
0.01106550544500351,
0.018691496923565865,
-0.01658378168940544,
0.004794473294168711,
-0.00600467249751091,
0.026288537308573723,
-0.02568633295595646,
0.024366116151213646,
0.005156375002115965,
0.030550291761755943,
0.03416351601481438,
0.048871200531721115,
-0.012507321313023567,
-0.01090916432440281,
0.03508998453617096,
-0.00608573853969574,
0.003630597610026598,
0.009768449701368809,
-0.002824280643835664,
-0.03485836833715439,
0.010498044081032276,
0.010463301092386246,
-0.03807784616947174,
-0.016479553654789925,
-0.021459320560097694,
-0.0024276364129036665,
-0.038911666721105576,
-0.003155782585963607,
-0.018760982900857925,
0.027631916105747223,
-0.03856424242258072,
0.0038824810180813074,
-0.0268675796687603,
-0.02290692739188671,
-0.02529258467257023,
0.002783747622743249,
0.027608754113316536,
0.009090970270335674,
0.01737128011882305,
0.003155782585963607,
0.018344072625041008,
0.02259424515068531,
-0.0032136868685483932,
-0.0384252704679966,
0.012484160251915455,
-0.001954269129782915,
-0.011667709797620773,
-0.010243264958262444,
-0.005564600229263306,
0.02584846504032612,
-0.03351499140262604,
-0.01551834400743246,
-0.024157660081982613,
0.004108307883143425,
0.007550716400146484,
-0.011401350609958172,
-0.033213887363672256,
-0.01564573310315609,
0.02978595532476902,
0.027631916105747223,
0.024203984066843987,
-0.010799146257340908
] | 2025-01-17 | 1 | 39818091 | [
"Fusion protein",
"fusion protein",
"TLR10 transmembrane domain",
"PD1 extracellular domain",
"TLR10 intracellular domain",
"fusion protein armored CAR-T cells",
"inhibitory checkpoint protein",
"second generation anti-CEA CAR",
"extracellular domain",
"better anti-tumor activity",
"transmembrane domain",
"anti-CEA",
"rational designed PD1-TLR10 fusion protein",
"optimal PD1-TLR10 fusion proteins",
"efficacy",
"PD1-TLR10 armored CEA CAR-T cells",
"TLR10",
"CAR-T cells",
"chimeric antigen receptor",
"CEA",
"xenograft mouse model",
"CEA-positive tumor cells",
"PD1",
"The fusion protein",
"stronger cytotoxicity",
"stimulatory molecule",
"solid tumors",
"T (CAR-T) cells",
"colon cancer",
"xenograft"
] | [
"CAR-T",
"Fusion protein",
"Immune checkpoint",
"TLR10"
] | 0 | 10.1016/j.intimp.2025.114083 | [
"Peng",
"Huang",
"Wu",
"Wu",
"Lu",
"Zhang",
"Liu"
] | [
"Department of Bioengineering, School of Life Sciences, Fudan University, Songhu Road 2005, 200438 Shanghai, China; TriArm Therapeutics, Niudun Road 200, 201203 Shanghai, China.",
"TriArm Therapeutics, Niudun Road 200, 201203 Shanghai, China.",
"TriArm Therapeutics, Niudun Road 200, 201203 Shanghai, China.",
"TriArm Therapeutics, Niudun Road 200, 201203 Shanghai, China.",
"TriArm Therapeutics, Niudun Road 200, 201203 Shanghai, China.",
"TriArm Therapeutics, Niudun Road 200, 201203 Shanghai, China.",
"TriArm Therapeutics, Niudun Road 200, 201203 Shanghai, China. Electronic address: [email protected]."
] | [
"39818091"
] | [] | 9.321208 | 5.794305 |
39816133 | 23 | La dolce vita: fueling chimeric antigen receptor (CAR) T cells with Glut1 to improve therapeutic efficacy. | The approval of chimeric antigen receptor (CAR) T cell therapies for the treatment of hematological cancers has marked a new era in cancer care, with seven products being FDA approved since 2017. However, challenges remain, and while profound effects are observed initially in myeloma, the majority of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immune evasion mechanisms, and poor infiltration and persistence. In this recent study, Guerrero et al endeavor to improve the efficacy of human CAR T cells by overexpressing the glucose transporter | [
0.025006605312228203,
-0.0020679000299423933,
0.06670026481151581,
0.059987083077430725,
-0.029609929770231247,
-0.036203235387802124,
0.02113453671336174,
0.0284830741584301,
0.02658899873495102,
-0.006521377246826887,
0.009476376697421074,
-0.045457836240530014,
-0.07264622300863266,
0.022884760051965714,
0.01318660844117403,
-0.01995973102748394,
0.04298834502696991,
-0.02230934426188469,
0.049965258687734604,
0.02041526697576046,
0.009961883537471294,
-0.015356404706835747,
-0.007804074790328741,
0.01733439601957798,
-0.05250667780637741,
0.004195739049464464,
-0.0026058536022901535,
0.02467094548046589,
-0.03848092257976532,
-0.016051698476076126,
0.010615220293402672,
-0.026708876714110374,
0.00879306998103857,
-0.0048910328187048435,
0.0017487241420894861,
0.020726950839161873,
0.026205386966466904,
0.024095529690384865,
-0.012095716781914234,
-0.03886453062295914,
0.023651979863643646,
0.015608149580657482,
0.028842709958553314,
0.08506561070680618,
-0.06219284236431122,
0.0190007034689188,
-0.013366426341235638,
-0.07154334336519241,
0.005999906919896603,
0.02163802646100521,
-0.03888850659132004,
0.0044744559563696384,
-0.03541203960776329,
0.03536408767104149,
-0.0427246131002903,
0.023604029789566994,
-0.0225730761885643,
0.015560198575258255,
-0.01069314032793045,
-0.007612269371747971,
-0.005040880758315325,
-0.013306486420333385,
0.013066730462014675,
-0.030017515644431114,
-0.06132971867918968,
0.012155655771493912,
-0.07557125389575958,
-0.038816582411527634,
-0.005433482117950916,
0.04159775748848915,
-0.009074783883988857,
-0.016063686460256577,
0.012599204666912556,
-0.023843785747885704,
0.01056726835668087,
0.014217562042176723,
0.0018341373652219772,
0.0272842925041914,
0.012623180635273457,
0.012551253661513329,
0.009188668802380562,
-0.0009530321694910526,
0.014481293968856335,
-0.047136131674051285,
-0.01879691146314144,
0.004399531986564398,
0.0072885979898273945,
-0.043803516775369644,
-0.042844489216804504,
-0.021745916455984116,
-0.0033086398616433144,
0.02114652469754219,
-0.036658771336078644,
0.026061533018946648,
-0.015476283617317677,
0.02117050066590309,
-0.010063779540359974,
-0.05864444375038147,
0.04210124537348747,
0.02234530821442604,
0.040470901876688004,
0.03018534556031227,
-0.026972608640789986,
-0.007312573958188295,
0.04229304939508438,
0.0006237415946088731,
-0.05408906936645508,
-0.013977805152535439,
0.01618356443941593,
-0.02515045925974846,
0.061377670615911484,
-0.04083053395152092,
-0.0017726997612044215,
0.050924286246299744,
-0.03131220117211342,
-0.04493037238717079,
-0.0403270460665226,
-0.014757013879716396,
0.029082465916872025,
0.04651276394724846,
-0.010651183314621449,
0.025701899081468582,
0.006910981610417366,
-0.022872772067785263,
0.024599019438028336,
0.00004380707468953915,
0.08612053841352463,
-0.01753818988800049,
-0.04648878797888756,
-0.052123066037893295,
0.02925029583275318,
-0.005433482117950916,
0.023915713652968407,
-0.006731164176017046,
-0.06195308640599251,
-0.004648279398679733,
-0.024179445579648018,
-0.026541046798229218,
-0.04862262308597565,
0.003590353997424245,
-0.013953829184174538,
-0.020343340933322906,
-0.016303442418575287,
-0.009032826870679855,
-0.014697074890136719,
-0.0427725613117218,
0.005397518631070852,
0.03510035574436188,
0.019791901111602783,
0.03610733151435852,
-0.02136230655014515,
0.059507567435503006,
0.04718408361077309,
-0.0062456573359668255,
0.00020398035121615976,
-0.04483446851372719,
0.0007200188119895756,
0.06626870483160019,
-0.041214145720005035,
-0.055959172546863556,
-0.022968674078583717,
0.015752002596855164,
-0.028075488284230232,
-0.03879260644316673,
0.02536623924970627,
-0.02680477872490883,
-0.01093889120966196,
0.017250481992959976,
-0.0475197434425354,
0.0020049638114869595,
-0.05317799746990204,
-0.03399747610092163,
-0.05763746798038483,
-0.0356278195977211,
-0.043563760817050934,
0.0005821587983518839,
0.013438353314995766,
0.04790335148572922,
-0.025006605312228203,
-0.04416315257549286,
0.008115758188068867,
0.03776165097951889,
0.027476096525788307,
0.0018536176066845655,
-0.013977805152535439,
0.015859894454479218,
-0.01400178112089634,
0.026541046798229218,
-0.03150400519371033,
-0.010483353398740292,
0.01328251138329506,
0.007084805052727461,
0.06540557742118835,
-0.009122735820710659,
0.00463629188016057,
-0.017034700140357018,
0.031743764877319336,
0.023616017773747444,
-0.03733009099960327,
-0.031072445213794708,
-0.002174291992560029,
-0.025797801092267036,
-0.03728213906288147,
-0.0001822524209273979,
-0.030928591266274452,
-0.040758609771728516,
-0.01565610058605671,
0.01460117194801569,
-0.0031977526377886534,
0.011712105944752693,
0.021446220576763153,
-0.001877593225799501,
-0.012503302656114101,
0.02350812591612339,
-0.03397350013256073,
-0.014804964885115623,
0.0016708032926544547,
0.0166151262819767,
0.06224079430103302,
0.04258075729012489,
-0.010069773532450199,
-0.0021667995024472475,
-0.0021128542721271515,
0.015032733790576458,
-0.035292159765958786,
-0.00598492193967104,
0.013678109273314476,
-0.02396366372704506,
0.0046692583709955215,
-0.005544369574636221,
0.008187685161828995,
0.0042167180217802525,
0.023148491978645325,
-0.016902834177017212,
-0.03016136959195137,
-0.030760761350393295,
0.047160107642412186,
0.008625240996479988,
0.055431708693504333,
-0.006521377246826887,
-0.01635139435529709,
0.03131220117211342,
0.02230934426188469,
-0.04255678132176399,
-0.01638735830783844,
-0.010992836207151413,
-0.019408291205763817,
-0.06334367394447327,
0.02229735627770424,
-0.0003993444552179426,
-0.003563381265848875,
0.028650904074311256,
-0.016519224271178246,
0.008043831214308739,
0.029034513980150223,
0.003743198700249195,
0.03586757555603981,
-0.041238121688365936,
0.009074783883988857,
-0.026996584609150887,
0.02280084416270256,
0.010045798495411873,
-0.017454273998737335,
-0.03629913553595543,
-0.02634924091398716,
0.0007679701084271073,
-0.005409506615251303,
0.006695200689136982,
0.02474287338554859,
-0.013510280288755894,
0.06689207255840302,
0.00900285691022873,
0.045505788177251816,
-0.013977805152535439,
-0.03272676467895508,
0.0034225243143737316,
0.0011545774759724736,
0.04298834502696991,
-0.0013111684238538146,
0.03771369904279709,
0.006916975602507591,
0.022680966183543205,
-0.018808899447321892,
-0.013390401378273964,
-0.0062396633438766,
-0.013498292304575443,
0.021086586639285088,
0.013630158267915249,
-0.016003748401999474,
-0.007270616479218006,
-0.007234652992337942,
-0.002679279074072838,
-0.013066730462014675,
-0.024347275495529175,
-0.006185718346387148,
-0.016015736386179924,
-0.004045891109853983,
-0.010501335375010967,
-0.027931634336709976,
0.019336363300681114,
-0.036490943282842636,
0.02117050066590309,
-0.05389726534485817,
-0.030928591266274452,
0.01920449733734131,
0.03742599114775658,
-0.0017037697834894061,
-0.02395167574286461,
0.022668978199362755,
0.052890289574861526,
0.007480403408408165,
-0.0024904708843678236,
0.05087633430957794,
0.031743764877319336,
0.002635823329910636,
0.02754802443087101,
0.0474957674741745,
-0.06593304127454758,
0.03212737292051315,
-0.04059077799320221,
-0.018581129610538483,
-0.04059077799320221,
-0.04150185361504555,
0.054472681134939194,
0.0001873097789939493,
-0.05418497323989868,
0.019875815138220787,
-0.01591983251273632,
0.027643926441669464,
-0.03246303275227547,
-0.001537438714876771,
-0.031480029225349426,
0.041190169751644135,
-0.024886727333068848,
0.02632526494562626,
-0.007228659000247717,
-0.01871299557387829,
-0.03661081939935684,
0.021254414692521095,
0.004219714552164078,
0.014529244974255562,
-0.002426036400720477,
-0.05552760884165764,
0.0617612786591053,
0.019384315237402916,
-0.019072631374001503,
-0.002937017474323511,
0.007887989282608032,
-0.02874680608510971,
0.021026646718382835,
-0.0017157576512545347,
0.019156545400619507,
0.017718005925416946,
0.022908736020326614,
-0.021985672414302826,
0.04126209765672684,
-0.06396704167127609,
-0.0166391022503376,
0.015500258654356003,
-0.003284664358943701,
-0.0001524701656308025,
0.008355515077710152,
-0.04198136553168297,
0.04576952010393143,
0.054952193051576614,
0.04066270589828491,
-0.012455351650714874,
0.020822852849960327,
-0.028698856011033058,
-0.004078857600688934,
-0.04054282605648041,
-0.004123812075704336,
0.028123440220952034,
0.008757106959819794,
-0.05557556077837944,
0.03584359958767891,
-0.021074598655104637,
0.016986750066280365,
0.01566808857023716,
0.0033685790840536356,
0.022141514346003532,
-0.017502225935459137,
-0.012275533750653267,
-0.006970920599997044,
-0.013078718446195126,
0.020139547064900398,
0.02634924091398716,
-0.007390494924038649,
-0.05423292517662048,
0.016495248302817345,
-0.028794758021831512,
-0.0014557716203853488,
0.017753969877958298,
0.01257522962987423,
-0.033110376447439194,
0.08607259392738342,
-0.025126483291387558,
0.07902374863624573,
0.04962959885597229,
-0.007983892224729061,
-0.011544276028871536,
-0.04658469185233116,
-0.0028575980104506016,
-0.022668978199362755,
-0.01872498355805874,
-0.030305223539471626,
0.028890660032629967,
0.01638735830783844,
0.016806932166218758,
-0.00677911564707756,
-0.01530845370143652,
0.015763990581035614,
0.03498047590255737,
0.01570405252277851,
-0.018617093563079834,
-0.00730657996609807,
-0.05538375675678253,
0.03212737292051315,
-0.016099650412797928,
0.04493037238717079,
0.04723203554749489,
-0.015140623785555363,
0.004354577977210283,
-0.008691173978149891,
-0.00587103795260191,
-0.005349567160010338,
0.015080684795975685,
0.009985859505832195,
-0.0000648560089757666,
-0.04493037238717079,
-0.03845694661140442,
0.039775606244802475,
0.03272676467895508,
-0.024982629343867302,
-0.010783049277961254,
0.022225430235266685,
-0.026732852682471275,
0.011604215949773788,
-0.036730699241161346,
0.00569122051820159,
-0.02826729416847229,
-0.004237696528434753,
0.036442991346120834,
-0.028411148115992546,
0.01316263247281313,
-0.00766621483489871,
-0.003455490805208683,
0.025006605312228203,
-0.0075403423979878426,
-0.029561979696154594,
-0.0043455869890749454,
-0.02610948495566845,
-0.02682875469326973,
-0.026780802756547928,
-0.05955551937222481,
0.0077441358007490635,
0.01662711426615715,
-0.07298188656568527,
-0.011975837871432304,
0.012359448708593845,
0.021673988550901413,
-0.04852671921253204,
-0.007024866063147783,
-0.03991946205496788,
0.0024410211481153965,
0.037641774863004684,
0.0594116672873497,
-0.010711122304201126,
0.0032337161246687174,
-0.04013524204492569,
0.02733224257826805,
-0.006952939089387655,
-0.01615959033370018,
-0.004483446944504976,
-0.029538003727793694,
0.04915008693933487,
0.006521377246826887,
0.03442903608083725,
0.0225970521569252,
-0.0061737303622066975,
-0.027715854346752167,
0.005960946436971426,
-0.02064303681254387,
0.010711122304201126,
0.02565394714474678,
0.0332542285323143,
0.006575322709977627,
-0.018209507688879967,
-0.07398886233568192,
0.031959544867277145,
-0.006143760867416859,
-0.01081301923841238,
-0.010759074240922928,
-0.010819013230502605,
-0.029873661696910858,
-0.006785109639167786,
-0.0006690705195069313,
0.01069314032793045,
-0.02829127013683319,
-0.0056402720510959625,
0.010477360337972641,
0.00866719800978899,
0.0033236248418688774,
-0.002102365018799901,
0.040758609771728516,
0.0521710179746151,
-0.007750129327178001,
0.048071183264255524,
0.0332542285323143,
0.028698856011033058,
-0.042604733258485794,
-0.012455351650714874,
0.039751630276441574,
0.0028381177689880133,
-0.045985300093889236,
-0.014097683131694794,
-0.05490424484014511,
-0.012431375682353973,
-0.0083195511251688,
-0.001609365688636899,
-0.0136421462520957,
-0.0052956221625208855,
0.005793116986751556,
0.0053315856494009495,
0.011790026910603046,
-0.027452122420072556,
-0.017430299893021584,
-0.010866964235901833,
-0.02307656593620777,
-0.025701899081468582,
0.02066701278090477,
-0.026636948809027672,
-0.005682229530066252,
0.02402360364794731,
-0.002264200709760189,
-0.0332542285323143,
-0.03780960291624069,
0.047855399549007416,
-0.022501150146126747,
-0.02898656390607357,
-0.013929854147136211,
-0.03291856870055199,
0.0355558916926384,
-0.010842988267540932,
-0.016339406371116638,
0.011424398049712181,
0.0074324519373476505,
-0.025821777060627937,
0.012982815504074097,
-0.014217562042176723,
0.022441210225224495,
-0.009728120639920235,
0.013030766509473324,
-0.006383517291396856,
0.016555188223719597,
-0.010962867178022861,
-0.015787966549396515,
-0.026493094861507416,
-0.018353361636400223,
-0.03466879203915596,
-0.010950879193842411,
-0.020762914791703224,
0.00694694509729743,
-0.00785802025347948,
-0.038337066769599915,
0.03658684343099594,
-0.013114681467413902,
-0.017286445945501328,
-0.04795130342245102,
0.014049732126295567,
0.0010204636491835117,
0.03136015310883522,
0.014469305984675884,
-0.02066701278090477,
0.03615528345108032,
0.01258721761405468,
-0.011897916905581951,
0.02802753634750843,
0.009698151610791683,
0.037857554852962494,
-0.007054835557937622,
-0.030784737318754196,
-0.018329385668039322,
0.050252966582775116,
0.0035873570013791323,
0.019899791106581688,
-0.041429925709962845,
-0.0012894405517727137,
-0.022836808115243912,
-0.0032427068799734116,
0.05437677726149559,
0.02064303681254387,
0.030976543202996254,
0.02517443522810936,
-0.03898441046476364,
0.020607072860002518,
0.00017504098650533706,
-0.02089478075504303,
-0.024622995406389236,
0.009488364681601524,
-0.011885929852724075,
-0.00629360880702734,
0.004522407427430153,
-0.07523559778928757,
-0.01590784452855587,
0.044043272733688354,
0.003329618601128459,
-0.010501335375010967,
0.00582908047363162,
-0.005400515627115965,
0.054712437093257904,
0.014205574057996273,
-0.043060269206762314,
0.0038720679003745317,
0.030688835307955742,
0.01400178112089634,
-0.04488242045044899,
-0.003374573076143861,
0.010195646435022354,
-0.023376259952783585,
0.002183282747864723,
-0.009452400729060173,
-0.016291456297039986,
-0.009488364681601524,
-0.010123719461262226,
-0.04330002889037132,
-0.011574245989322662,
0.0035154300276190042,
0.015835918486118317,
-0.0037701711989939213,
0.014445330016314983,
-0.03943994641304016,
-0.006077827885746956,
0.023795833811163902,
-0.001000234275124967,
-0.036419015377759933,
0.01462514791637659,
-0.019648047164082527,
-0.0030673849396407604,
0.003964973613619804,
-0.00299246096983552,
-0.010729104280471802,
0.006365535780787468,
-0.016483260318636894,
0.005957949440926313,
-0.01117265410721302,
-0.01759812794625759,
-0.02302861399948597,
0.0033625850919634104,
-0.01613561436533928,
0.01807764172554016,
-0.024071553722023964,
0.01761011593043804,
-0.03402144834399223,
0.0019180522067472339,
-0.022201454266905785,
-0.007660220842808485,
0.0024994616396725178,
0.07456427812576294,
0.08022253215312958,
-0.023364271968603134,
0.033110376447439194,
0.002235729480162263,
-0.0002103488805005327,
-0.02188977040350437,
-0.011598221957683563,
0.014121659100055695,
-0.010123719461262226,
0.020007681101560593,
0.021266402676701546,
0.08228443562984467,
0.017238494008779526,
-0.014025756157934666,
-0.03344603627920151,
0.009410443715751171,
-0.010255585424602032,
-0.022944698110222816,
-0.03128822520375252,
-0.030544981360435486,
0.002631327835842967,
-0.004471458960324526,
0.0213742945343256,
-0.03275074064731598,
-0.055911220610141754,
0.0034405060578137636,
0.004792133346199989,
0.008121752180159092,
0.016818920150399208,
0.01174207590520382,
0.008343527093529701,
0.000060641541494987905,
-0.008103770203888416,
-0.029034513980150223,
0.01461315993219614,
0.011604215949773788,
0.0009777570376172662,
0.017909811809659004,
-0.020259425044059753,
-0.02752404846251011,
-0.001954015577211976,
0.033350132405757904,
0.014085695147514343,
0.049533698707818985,
-0.02680477872490883,
0.024575043469667435,
0.00015012879157438874,
0.01461315993219614,
-0.03522023186087608,
0.0017007727874442935,
0.017466261982917786,
0.018916789442300797,
-0.001841629738919437,
-0.017682043835520744,
-0.016567176207900047,
0.020702974870800972,
-0.0002594240359030664,
-0.01355823129415512,
0.03246303275227547,
0.014721049927175045,
0.04675251990556717,
0.017238494008779526,
0.02685273066163063,
-0.023364271968603134,
0.021074598655104637,
0.031024493277072906,
0.018185531720519066,
-0.03224725276231766,
0.05979527533054352,
-0.019803889095783234,
-0.009278577752411366,
0.009440412744879723,
-0.004483446944504976,
-0.04560168832540512,
-0.0427006371319294,
-0.005865043960511684,
0.03435710817575455,
-0.018701009452342987,
-0.028195366263389587,
-0.02419143356382847,
0.005802107974886894,
0.022692954167723656,
-0.036490943282842636,
-0.03517227992415428,
0.008403466083109379,
-0.01091491524130106,
0.00900285691022873,
0.028650904074311256,
0.0053525641560554504,
-0.004522407427430153,
-0.03826513886451721,
0.023663967847824097,
0.008966893889009953,
0.0024440179113298655,
-0.00784603226929903,
-0.003653289983049035,
-0.0284830741584301,
0.00794792827218771,
0.0072166710160672665,
-0.029753783717751503,
-0.0380253829061985,
-0.0190007034689188,
0.023472163826227188,
0.0019690003246068954,
0.007240646984428167,
0.020607072860002518,
0.004663264378905296,
0.028507050126791,
0.011226599104702473,
-0.004612315911799669,
0.01010573748499155,
-0.02165001444518566,
-0.023352285847067833,
0.020031657069921494,
-0.030736785382032394,
-0.02539021521806717,
0.02161405049264431,
-0.018904801458120346,
0.018617093563079834,
-0.003509436035528779,
0.011136690154671669,
-0.002012456301599741,
-0.0036742687225341797,
-0.020595084875822067,
0.025965631008148193,
-0.0018476237310096622,
-0.025222385302186012,
0.006515383254736662,
0.03896043449640274,
-0.020127559080719948,
0.0006125029758550227,
-0.02874680608510971,
0.01852119155228138,
-0.03447698801755905,
0.03222327679395676,
-0.015476283617317677,
0.027164414525032043,
0.05399316921830177,
-0.06703592091798782,
-0.023160479962825775,
0.021302366629242897,
-0.015116648748517036,
0.00021334584744181484,
0.005601311568170786,
-0.026684900745749474,
0.0003347225720062852,
0.032415080815553665,
-0.0072885979898273945,
0.0249586533755064,
-0.008073801174759865,
0.003500445280224085,
-0.0068510426208376884,
-0.005337579641491175,
-0.0202114749699831,
-0.027236340567469597,
-0.061377670615911484,
-0.020319364964962006,
0.04874249920248985,
0.014049732126295567,
-0.008613253012299538,
-0.0002182158932555467,
0.025294313207268715,
0.025534069165587425,
0.01801770180463791,
-0.029561979696154594,
-0.031911592930555344,
-0.03886453062295914,
-0.006179724354296923,
0.01426551304757595,
0.010363475419580936,
-0.02093074470758438,
0.025342263281345367,
0.0009208148694597185,
-0.05672639235854149,
0.03251098468899727,
-0.005382533650845289,
-0.015344417653977871,
0.004941981285810471,
-0.014073708094656467,
0.00747440941631794,
0.020750926807522774,
0.015596161596477032,
-0.01852119155228138,
-0.003043409436941147,
-0.03888850659132004,
-0.010177664458751678,
0.008811051957309246,
-0.03133617714047432,
0.006263638846576214,
-0.021566098555922508,
-0.01848522759974003,
0.00877508893609047,
-0.016231516376137733,
-0.017646079882979393,
0.001210770453326404,
0.036251187324523926,
0.010363475419580936,
0.007738141808658838,
-0.04231702536344528,
0.05006116256117821,
0.04540988430380821,
-0.0166391022503376,
-0.0017142591532319784,
-0.0202114749699831,
-0.03584359958767891,
0.04394736886024475,
-0.03426120802760124,
-0.0026193400844931602,
-0.014121659100055695,
0.008259612135589123,
-0.031456056982278824,
0.027859708294272423,
-0.013138657435774803,
0.015476283617317677,
-0.008013861253857613,
0.00808578822761774,
0.009092765860259533,
-0.0012744558043777943,
-0.01424153707921505,
-0.0006986655062064528,
-0.010171670466661453,
0.019348351284861565,
-0.01878492347896099,
-0.0006683212704956532,
0.0032966521102935076,
0.01140042208135128,
0.029490051791071892,
-0.015068696811795235,
-0.009326528757810593,
-0.015164599753916264,
-0.0023061579558998346,
0.032894592732191086,
-0.005730181001126766,
0.004270663019269705,
-0.0007409974932670593,
0.02113453671336174,
0.011963849887251854,
-0.021997660398483276,
0.03840899467468262,
-0.028794758021831512,
0.009080777876079082,
-0.029777759686112404,
-0.0332542285323143,
-0.03522023186087608,
0.0545685850083828,
-0.004288644529879093,
0.011340483091771603,
-0.02773982845246792,
0.024131493642926216,
-0.022273380309343338,
0.05667844042181969,
-0.0004495434695854783,
0.010303536430001259,
0.003020932199433446,
0.02426335960626602,
-0.020487194880843163,
0.002899555489420891,
-0.02066701278090477,
0.07547535002231598,
0.017622103914618492,
0.00855331402271986,
-0.00902683287858963,
-0.00006139078323030844,
-0.0024005621671676636,
0.014852916821837425,
0.006515383254736662,
0.010507329367101192,
0.00039185205241665244,
0.03176773712038994,
0.014313464052975178,
0.008373496122658253,
0.004024912603199482,
-0.015092672780156136,
0.03783357888460159,
0.020043645054101944,
0.012455351650714874,
0.011568251997232437,
0.01876094751060009,
0.008853009901940823,
-0.03728213906288147,
0.005553360562771559,
-0.009614236652851105,
0.0570620521903038,
-0.002859096508473158,
-0.04838286712765694,
0.02447914145886898,
0.001958511071279645,
-0.006011894904077053,
-0.04656071588397026,
0.02446715347468853,
0.04871852323412895,
0.07087202370166779,
-0.024083541706204414,
0.01877293549478054,
0.008882978931069374,
-0.013965817168354988,
-0.0213503185659647,
0.02754802443087101,
-0.042173173278570175,
0.037881530821323395,
-0.029873661696910858,
-0.04552976414561272,
0.017466261982917786,
-0.006707188673317432,
-0.0006331070326268673,
0.008954905904829502,
0.05202716588973999,
0.03037715144455433,
0.001151580479927361,
-0.050492722541093826,
0.03279869258403778,
0.008115758188068867,
-0.011304520070552826,
0.015847906470298767,
0.0010107235284522176,
0.024982629343867302,
0.016267480328679085,
0.033805668354034424,
-0.01636338233947754,
-0.004989932756870985,
0.031192323192954063,
0.03735406696796417,
0.03394952416419983,
-0.020559120923280716,
-0.0014527746243402362,
-0.02872283197939396,
0.006593304220587015,
0.008121752180159092,
-0.01925244927406311,
-0.021290378645062447,
0.008043831214308739,
0.06391908973455429,
0.031911592930555344,
-0.0249346774071455,
-0.006575322709977627,
0.011975837871432304,
-0.039056338369846344,
-0.017646079882979393,
-0.04207726940512657,
0.022441210225224495,
0.03687455132603645,
-0.016962774097919464,
-0.042604733258485794,
0.028387172147631645,
0.011418404057621956,
-0.05130789428949356,
-0.009098759852349758,
0.04224509745836258,
0.004150784574449062,
0.044762540608644485,
-0.0064614382572472095,
0.03150400519371033,
0.005895013455301523,
0.012874925509095192,
0.013797987252473831,
0.012173637747764587,
-0.023867761716246605,
-0.004420510958880186,
-0.03109642118215561,
-0.029082465916872025,
-0.009853992611169815,
-0.033110376447439194,
0.00160487019456923,
0.012779022566974163,
0.02706851065158844,
0.010279560461640358,
0.01211969181895256,
0.006347553804516792,
-0.026996584609150887,
-0.0005372044397518039,
0.01460117194801569,
0.02423938363790512,
0.0023586046881973743,
-0.001586888451129198,
-0.01565610058605671,
-0.022237416356801987,
0.016699042171239853,
0.005073847249150276,
0.048310939222574234,
0.029490051791071892,
0.0030224306974560022,
-0.030928591266274452,
-0.016794944182038307,
-0.0018910795915871859,
0.04186148941516876,
-0.027356218546628952,
0.0013433857820928097,
-0.021218452602624893,
-0.012563241645693779,
0.0190007034689188,
0.01611163839697838,
0.048095159232616425,
0.0284590981900692,
0.009092765860259533,
-0.007024866063147783,
0.005157762207090855,
0.02874680608510971,
0.008109764195978642,
-0.0025833765976130962,
0.022752894088625908,
-0.014061720110476017,
-0.01924046128988266,
0.051164042204618454,
-0.014493281953036785,
-0.007983892224729061,
-0.03162388503551483,
-0.022896748036146164,
0.030257273465394974,
0.01943226531147957,
0.007648232858628035,
0.0039769611321389675,
0.001658815424889326,
0.001600374816916883,
-0.00664125569164753,
0.014397379010915756,
0.004738188348710537,
-0.004765160847455263,
-0.005957949440926313,
-0.009218637831509113,
0.006479419767856598,
-0.022836808115243912,
-0.0009889956563711166,
0.02326836995780468,
0.0379774309694767,
-0.01874895952641964,
-0.02325638197362423,
0.000982252531684935,
-0.019779913127422333,
-0.02515045925974846,
0.00677911564707756,
-0.0008728635730221868,
-0.011208617128431797,
-0.008691173978149891,
-0.023879749700427055,
-0.009524327702820301,
-0.02354408986866474,
0.01568007655441761,
-0.00659929821267724,
0.006443456280976534,
0.03840899467468262,
0.011190635152161121,
-0.03663479536771774,
0.015620137564837933,
-0.0038181226700544357,
-0.03447698801755905,
-0.03246303275227547,
0.043324004858732224,
0.005670241545885801,
-0.043347977101802826,
-0.0032966521102935076,
-0.00605984590947628,
-0.0201635230332613,
0.020103584975004196,
0.022453198209404945,
-0.0060448613949120045,
0.015260502696037292,
0.0015224538510665298,
0.02069098688662052,
-0.018868837505578995,
0.0008106767199933529,
-0.014577195979654789,
-0.032439056783914566,
-0.030281247571110725,
0.002962491475045681,
0.0071147745475173,
0.0027916650287806988,
-0.005085835233330727,
-0.03390157222747803,
0.013678109273314476,
-0.013054742477834225,
0.009176680818200111,
-0.002367595676332712,
0.005904004443436861,
0.029609929770231247,
-0.01152030099183321,
-0.002550409873947501,
0.02515045925974846,
-0.027236340567469597,
-0.00985998660326004,
0.015740014612674713,
0.018245471641421318,
0.011190635152161121,
0.02258506417274475,
-0.003599344752728939,
-0.01283896155655384,
-0.02922631986439228,
-0.023436199873685837,
-0.01426551304757595,
0.05437677726149559,
-0.025821777060627937,
-0.02258506417274475,
0.04778347536921501,
-0.0017022712854668498,
-0.015116648748517036,
-0.005981924943625927,
0.01530845370143652,
0.021985672414302826,
0.003773168195039034,
-0.0017816906329244375,
0.043084245175123215,
0.024622995406389236,
-0.013210584409534931,
0.0038660739082843065,
0.009254601784050465,
-0.012359448708593845,
0.00581709248945117,
-0.01705867610871792,
0.012137673795223236,
0.015380380675196648,
0.003101849928498268,
-0.01831739768385887,
0.003869070904329419,
-0.00006214001768967137,
0.008493375033140182,
0.049725502729415894,
0.002390072913840413,
0.004738188348710537,
0.04298834502696991,
0.0031258256640285254,
-0.004876048304140568,
-0.005505409091711044,
-0.005751159507781267,
-0.015128636732697487,
-0.014385391026735306,
-0.02781175635755062,
-0.03778562694787979,
0.011208617128431797,
0.0018910795915871859,
0.0032906581182032824,
0.00011791150609496981,
0.02805151231586933,
-0.000060454232880147174,
-0.05586326867341995,
-0.019803889095783234,
0.0034794665407389402,
-0.003272676607593894,
-0.01802968978881836,
-0.008763100951910019,
-0.03896043449640274,
-0.012395411729812622,
0.007804074790328741,
-0.002318145940080285,
0.009176680818200111,
0.04210124537348747,
-0.010021822527050972,
0.03203147277235985,
0.006485413759946823,
-0.00124598469119519,
0.003964973613619804,
0.0006548350211232901,
-0.06372728198766708,
0.008709155954420567,
-0.03613130748271942,
-0.004989932756870985,
-0.0009455397957935929,
-0.01901269145309925,
-0.054520633071660995,
-0.022992650046944618,
0.014145635068416595,
0.006881012115627527,
-0.018233483657240868,
0.004171763546764851,
0.01092690322548151,
0.008637228980660439,
0.005544369574636221,
0.02017551101744175,
-0.023472163826227188,
0.02421540766954422,
0.00658731022849679,
0.020559120923280716,
0.010968861170113087,
-0.012898900546133518,
-0.03967970237135887,
0.0019794898107647896,
0.005283634178340435,
0.011502319015562534,
-0.014121659100055695,
-0.007408476434648037,
0.0004487942496780306,
-0.017190542072057724,
0.057589516043663025,
0.0060448613949120045,
0.011496325023472309,
-0.016758980229496956,
-0.017634091898798943,
-0.0008256615255959332,
0.003245703876018524,
0.0249586533755064,
0.027188388630747795,
0.035531915724277496,
-0.04433098062872887,
-0.019767925143241882,
-0.008984875865280628,
0.00243952265009284,
-0.023436199873685837,
-0.0030059474520385265,
-0.0017682043835520744,
-0.0037671742029488087,
-0.026780802756547928,
0.0004997425130568445,
-0.0046902368776500225,
0.039991386234760284,
0.023795833811163902,
-0.012419387698173523,
0.008859002962708473,
-0.0062396633438766,
-0.021901758387684822,
-0.021086586639285088,
0.01316263247281313,
0.0178498737514019,
0.031216299161314964,
0.015476283617317677,
0.008031843230128288,
-0.0249586533755064,
0.035459987819194794,
0.005292625166475773,
0.02397565171122551,
-0.030305223539471626,
-0.04663264378905296,
0.007756123319268227,
0.00867918599396944,
-0.0237358957529068,
0.008127746172249317,
0.027643926441669464,
-0.005520394071936607,
-0.009338516741991043,
0.02996956557035446,
-0.012982815504074097,
-0.003863076912239194,
-0.026900680735707283,
-0.015548210591077805,
0.01926443725824356,
-0.012041770853102207,
0.007498385384678841,
0.008373496122658253,
-0.0055473665706813335,
-0.03464481607079506,
-0.0071027870289981365,
-0.013630158267915249,
0.00854132603853941,
0.017418311908841133,
-0.026301290839910507,
0.007684196345508099,
-0.006605292204767466,
-0.03248700872063637,
-0.06991299986839294,
0.006341559812426567,
0.003383563831448555,
-0.03706635907292366,
-0.0021982674952596426,
-0.004138797055929899,
0.0035663782618939877,
0.05015706270933151,
-0.01950419321656227,
0.002091875532642007,
0.0356278195977211,
0.02805151231586933,
-0.012779022566974163,
0.03114437125623226,
0.010201639495790005,
0.04063872992992401,
-0.003923016134649515,
-0.010657177306711674,
-0.01850920356810093,
0.007006884086877108,
0.03440506011247635,
-0.015344417653977871,
0.01950419321656227,
0.024047579616308212,
0.003353594336658716,
0.021470196545124054,
0.012173637747764587,
-0.01568007655441761,
0.04543386027216911,
-0.009776071645319462,
-0.0027497075498104095,
-0.028339220210909843,
-0.011933880858123302,
-0.021086586639285088,
-0.002751206047832966,
0.030521005392074585,
-0.016699042171239853,
-0.0005589323700405657,
0.019839851185679436,
0.04226907342672348,
-0.01826944760978222,
-0.027452122420072556,
0.003335612593218684,
0.023088552057743073,
0.015799954533576965,
0.021506160497665405,
-0.008019855245947838,
-0.012191618792712688,
-0.014493281953036785,
0.011837977916002274,
-0.0023271366953849792,
-0.025246361270546913,
0.006533365231007338,
0.0021443222649395466,
0.026756826788187027,
0.003410536563023925,
-0.016327418386936188,
0.014541232958436012,
0.005373543128371239,
-0.01611163839697838,
0.01293486449867487,
-0.00647342624142766,
-0.006881012115627527,
-0.0142535250633955,
-0.010213627479970455,
-0.006869024131447077,
0.016902834177017212,
-0.020702974870800972,
0.018401313573122025,
-0.018233483657240868,
0.01055528037250042,
0.01460117194801569,
-0.018629081547260284,
-0.0027796770446002483,
0.007420464418828487,
-0.03538806363940239,
0.012143667787313461,
-0.011040788143873215,
-0.01683090813457966,
-0.025725875049829483,
-0.0027721847873181105,
0.01637537032365799,
0.0026508080773055553,
-0.05629483237862587,
-0.005208710208535194,
-0.006916975602507591,
0.0037521894555538893,
0.0061377668753266335,
0.03864875063300133,
-0.005175743717700243,
-0.007696184329688549,
-0.029130417853593826,
-0.0008900960674509406,
-0.006104800384491682,
0.007150738034397364,
-0.010753080248832703,
-0.03447698801755905,
-0.015068696811795235,
0.002901053987443447,
-0.01496080681681633,
-0.012970827519893646,
-0.029825711622834206,
-0.0011613206006586552,
-0.024862751364707947,
0.003967970609664917,
0.002631327835842967,
0.009494357742369175,
-0.0177779458463192,
0.02111056074500084,
-0.04483446851372719,
0.011100727133452892,
-0.015775978565216064,
0.02304060198366642,
0.021014658734202385,
0.06684412062168121,
-0.007840038277208805,
0.015823930501937866,
-0.0022627022117376328,
0.020750926807522774,
-0.03754587098956108,
0.01246733870357275,
0.021014658734202385,
-0.008235636167228222,
-0.004537391941994429,
0.01174207590520382,
0.010795037262141705,
-0.01878492347896099,
0.0000856473998283036,
-0.023639993742108345,
0.005478436592966318,
0.02182983048260212,
-0.032415080815553665,
0.006964927073568106,
0.020355328917503357,
0.026900680735707283,
0.016255492344498634,
0.02661297284066677,
-0.03888850659132004,
0.02277687005698681,
-0.021254414692521095,
-0.019612083211541176,
-0.008325545117259026,
-0.023340297862887383,
-0.04013524204492569,
0.0050948262214660645,
0.016950786113739014,
0.003329618601128459,
0.05125994235277176,
0.00984799861907959,
-0.011070757173001766,
-0.004786139354109764,
-0.008757106959819794,
-0.02425137162208557,
0.0225730761885643,
-0.007420464418828487,
-0.007096793036907911,
0.017825897783041,
0.020846828818321228,
0.002012456301599741,
0.01246733870357275,
0.010819013230502605,
-0.0225251242518425,
0.0014040741370990872,
-0.011466355994343758,
-0.005924982950091362,
-0.03179171308875084,
-0.01034549344331026,
0.10760272294282913,
-0.007660220842808485,
-0.002388574415817857,
0.0356757715344429,
-0.0023526109289377928,
-0.022393258288502693,
0.023220418021082878,
-0.005085835233330727,
0.018641069531440735,
-0.012611192651093006,
0.008589277043938637,
0.016051698476076126,
0.04248485714197159,
0.02970583364367485,
0.015020745806396008,
-0.012791010551154613,
0.014493281953036785,
0.0641588419675827,
-0.004935987293720245,
-0.016998738050460815,
0.01388190221041441,
-0.01246733870357275,
0.004099836573004723,
0.009650199674069881,
-0.018904801458120346,
0.006557340733706951,
-0.007828050293028355,
-0.006545353215187788,
-0.00820566713809967,
-0.00712676253169775,
0.005268649663776159,
0.008601265028119087,
0.02445516549050808,
-0.01042940840125084,
0.008043831214308739,
-0.059459615498781204,
-0.01713060401380062,
-0.024766849353909492,
0.02399962767958641,
-0.005562351085245609,
0.0039559826254844666,
0.008643222972750664,
0.004357574973255396,
0.0012587216915562749,
0.016015736386179924,
0.003575369017198682,
-0.012065746821463108,
0.001160571351647377,
-0.005100819747895002,
-0.031695812940597534,
0.007330555468797684,
-0.002030438045039773,
0.009428424760699272,
-0.021925734356045723,
-0.039991386234760284,
-0.027404170483350754,
-0.004414516966789961,
0.005577336065471172,
0.0014040741370990872,
-0.02515045925974846,
-0.010795037262141705,
0.006773121654987335,
0.023412223905324936,
0.008229642175137997,
0.014757013879716396
] | 2025-01-16 | 21 | 39816133 | [
"CAR T cell therapy",
"poor CAR T cell persistence",
"human CAR T cells",
"Guerrero et al",
"cancer care",
"tumor antigen heterogeneity",
"immune evasion mechanisms",
"hematological cancers",
"poor infiltration",
"profound effects",
"chimeric antigen receptor",
"patients relapse",
"CAR",
"solid tumors",
"myeloma",
"Guerrero",
"persistence",
"FDA",
"challenges",
"a new era",
"this recent study",
"the glucose transporter",
"the efficacy",
"the majority",
"seven products",
"the treatment",
"The approval",
"2017",
"seven",
"which"
] | [
"Glut1",
"cancer",
"chimeric antigen receptor T cells",
"cytokines",
"glucose",
"glycolysis",
"metabolism",
"tumor"
] | 0 | 10.1097/IN9.0000000000000055
10.1038/s41423-024-01148-8
10.3389/fimmu.2023.1121565
10.1038/s41467-024-52666-y
10.1126/sciadv.adj1431
10.1016/j.ymthe.2024.05.006
10.20900/immunometab20200029
10.1038/s42003-024-06164-y
10.1136/jitc-2023-008434
10.1038/s41586-024-07962-4
10.4110/in.2020.20.e6
10.1016/j.cell.2015.08.016
10.7554/eLife.95652
10.1038/s41586-021-03442-1
10.1172/jci.insight.93411
10.1007/s00424-020-02411-3
10.1016/j.isci.2023.106150
10.1038/s41586-024-07242-1
10.1038/s41586-024-07300-8
10.1182/blood.2018885863 | [
"Slattery",
"Finlay",
"Darcy"
] | [
"School of Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Dublin, Ireland.",
"School of Biochemistry and Immunology, Trinity Biomedical Sciences, Trinity College Dublin, Dublin, Ireland.\nSchool of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences, Trinity College Dublin, Dublin, Ireland.",
"Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.\nSir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia."
] | [
"39816133",
"38565887",
"36999013",
"39370422",
"31747582",
"38809979",
"38720457",
"32879737",
"38627603",
"38964783",
"39322665",
"32158594",
"26321679",
"38787918",
"33828302",
"28614802",
"32591905",
"36890792",
"38600376",
"38600391",
"31076448"
] | [] | 8.369929 | 4.094183 |
39815137 | 24 | Optimal chemokine receptors for enhancing immune cell trafficking in adoptive cell therapy. | Recently, a strategy involving the engineering of chemokine receptors on immune cells was developed to optimize adoptive cell therapy (ACT) for solid tumors. Given the variability in chemokine secretion among different tumor types, identifying and modulating the appropriate chemokine receptors is crucial. In this study, we utilized extensive RNA sequencing data from both tumor tissues from The Cancer Genome Atlas and normal tissues from Genotype-Tissue Expression to investigate the expression profiles of chemokines. Through analysis, we identified eight chemokine receptors associated with increased chemokine levels in tumor tissues compared to normal tissues, making them promising candidates for enhancing ACT. Subsequent examination of tumor-infiltrating lymphocytes and chimeric antigen receptor-T cells revealed that five out of the eight candidate chemokine receptors did not exhibit elevated expression in T cells. Among five candidates, we demonstrated that CXCR5 is a particularly promising candidate for enhancing cell migration without compromising cell viability or cytotoxicity. In conclusion, our study underscores the potential of five chemokine receptors (CCR6, CCR9, CXCR1, CXCR5, and XCR1) as valuable targets for modulating ACT to enhance cell trafficking and potentially improve cancer therapy outcomes. | [
0.021250274032354355,
-0.0017371495487168431,
0.024123890325427055,
0.04518098011612892,
-0.011651428416371346,
-0.012237018905580044,
0.012943348847329617,
0.029846975579857826,
-0.018557768315076828,
-0.03211688995361328,
-0.011283171363174915,
-0.028567129746079445,
-0.01929428242146969,
0.028760313987731934,
0.032841332256793976,
-0.05148361995816231,
0.0478372648358345,
-0.008035260252654552,
0.0249690730124712,
0.024027299135923386,
0.017543550580739975,
0.03216518834233284,
-0.02644210308790207,
-0.011548799462616444,
-0.0278426893055439,
-0.007485892158001661,
0.0021567216608673334,
0.017640141770243645,
-0.02774609625339508,
-0.012200796976685524,
0.016311999410390854,
-0.01895621046423912,
-0.014935562387108803,
0.007045190315693617,
-0.06901509314775467,
-0.006127564702183008,
-0.015877336263656616,
0.01057080365717411,
-0.001589242834597826,
-0.006369045004248619,
0.05003473535180092,
0.03397629037499428,
0.011808390729129314,
0.05752062797546387,
-0.06573095917701721,
-0.049117110669612885,
-0.021032942458987236,
-0.08625679463148117,
0.0057623255997896194,
0.018038585782051086,
-0.0188596174120903,
-0.0012300406815484166,
-0.0039089638739824295,
0.021793605759739876,
-0.022300714626908302,
0.014911414124071598,
-0.02207130752503872,
0.0039934818632900715,
0.014802747406065464,
-0.005895140115171671,
0.01617918536067009,
-0.015140820294618607,
0.023001007735729218,
-0.030474824830889702,
-0.025355441495776176,
-0.0017869548173621297,
-0.050517696887254715,
-0.041776105761528015,
0.008143926039338112,
-0.00883818231523037,
0.0003799542901106179,
-0.018062733113765717,
0.019946280866861343,
0.015189116820693016,
0.030257493257522583,
-0.02617647312581539,
-0.008880441077053547,
0.03554591163992882,
-0.026079881936311722,
-0.018280064687132835,
0.01674666441977024,
-0.030160900205373764,
0.014923487789928913,
-0.07254070788621902,
-0.024498185142874718,
-0.023109672591090202,
0.028663722798228264,
-0.019753096625208855,
-0.06524799764156342,
0.0030909490305930376,
0.006513933651149273,
0.01850947178900242,
-0.01468200795352459,
0.050179623067379,
0.025355441495776176,
0.053560350090265274,
0.00726252282038331,
-0.04979325458407402,
0.05288420617580414,
0.025959141552448273,
0.050179623067379,
-0.026659434661269188,
-0.021298570558428764,
-0.006713154725730419,
0.04537416622042656,
-0.0017446958227083087,
-0.017145108431577682,
0.012726016342639923,
0.05829336494207382,
-0.005864955019205809,
0.07698395103216171,
0.01544267125427723,
-0.03977182134985924,
0.04660571366548538,
-0.013933418318629265,
-0.07051227241754532,
-0.06196386739611626,
-0.041607070714235306,
-0.013897196389734745,
0.04206588491797447,
-0.022650860249996185,
0.06563436985015869,
0.03660842776298523,
-0.019680650904774666,
-0.012110241688787937,
-0.016758738085627556,
0.08292436599731445,
-0.028229057788848877,
-0.03076460212469101,
-0.016191260889172554,
0.031537339091300964,
-0.021503828465938568,
0.032986219972372055,
-0.0023483966942876577,
-0.05674789100885391,
-0.03822634369134903,
0.014162824489176273,
0.029557200148701668,
-0.040013302117586136,
0.004600201267749071,
0.006610525771975517,
-0.02283197082579136,
0.0114522073417902,
-0.009912770241498947,
-0.054816048592329025,
-0.05249783769249916,
-0.034459251910448074,
0.06123942509293556,
-0.0005206920905038714,
0.06500651687383652,
-0.013824752531945705,
0.04530172049999237,
0.050517696887254715,
-0.012188722379505634,
-0.013812677934765816,
-0.030305787920951843,
-0.010588915087282658,
0.03965108096599579,
-0.012919200584292412,
-0.030426528304815292,
-0.012224944308400154,
0.01821969449520111,
-0.009924843907356262,
-0.021165756508708,
0.041751958429813385,
-0.015092524699866772,
-0.06003202497959137,
0.053125686943531036,
-0.04964836686849594,
0.01456126756966114,
0.016481036320328712,
-0.06404060125350952,
-0.04368380084633827,
0.01684325747191906,
-0.06964294612407684,
-0.02045338973402977,
0.0005003171972930431,
0.040134038776159286,
-0.02917083166539669,
0.0195478368550539,
0.01236379612237215,
0.056361522525548935,
0.0390956737101078,
-0.006124546285718679,
0.007823964580893517,
0.013547049835324287,
0.007787742651998997,
0.00834918487817049,
-0.03817804902791977,
-0.011053765192627907,
0.019366726279258728,
-0.01038365624845028,
0.028204908594489098,
0.032672297209501266,
-0.04358721151947975,
-0.025669366121292114,
0.0437079519033432,
0.04931029677391052,
-0.0005625738413073123,
-0.056458115577697754,
0.011518614366650581,
-0.017181329429149628,
-0.009985214099287987,
-0.02138308808207512,
-0.04061700031161308,
-0.001783936400897801,
-0.011482392437756062,
0.049165405333042145,
-0.007437596097588539,
0.03100608102977276,
0.03098193369805813,
-0.004090073984116316,
-0.00909777358174324,
0.05109725147485733,
-0.00838540680706501,
0.0086812200024724,
-0.007878297939896584,
0.021129533648490906,
0.024196334183216095,
0.019970428198575974,
-0.0035739096347242594,
-0.04382868856191635,
0.027238987386226654,
-0.007413447834551334,
-0.025331292301416397,
0.037405312061309814,
-0.005246161483228207,
-0.051773395389318466,
-0.017471106722950935,
-0.014947636052966118,
-0.017277922481298447,
0.03675331547856331,
0.0018156307050958276,
-0.04192099720239639,
-0.028349798172712326,
-0.010866617783904076,
0.01136768888682127,
0.005249179899692535,
0.052208058536052704,
-0.044794611632823944,
-0.009731659665703773,
-0.01993420533835888,
-0.002648737980052829,
0.014657859690487385,
-0.028760313987731934,
0.016734590753912926,
-0.0007165175629779696,
-0.06433037668466568,
-0.01627577841281891,
-0.006894265301525593,
0.017314143478870392,
0.03950619325041771,
0.019016580656170845,
-0.025669366121292114,
0.013365939259529114,
0.00046220855438150465,
0.018775099888443947,
-0.023314932361245155,
-0.01665007323026657,
0.002949079265818,
0.034169476479291916,
-0.003622205927968025,
-0.007926593534648418,
0.007552299182862043,
-0.009592808783054352,
-0.0009296995121985674,
-0.027504615485668182,
0.023773744702339172,
-0.000184317454113625,
-0.021322717890143394,
0.018002362921833992,
-0.005898158531636,
0.029001794755458832,
-0.021841900423169136,
-0.05027621611952782,
0.02936401590704918,
-0.009381513111293316,
0.014971784316003323,
0.00918229203671217,
0.012412091717123985,
-0.031416598707437515,
-0.006960672326385975,
0.03832293674349785,
-0.013378013856709003,
-0.04068944603204727,
-0.035811539739370346,
-0.004373813513666391,
0.008922700770199299,
-0.0043013691902160645,
-0.028325648978352547,
0.027118247002363205,
-0.008228444494307041,
-0.03692235052585602,
-0.05452627316117287,
-0.023725448176264763,
0.026635287329554558,
-0.02482418343424797,
-0.05013132840394974,
-0.027214840054512024,
0.02615232579410076,
-0.028736166656017303,
0.010836432687938213,
-0.010552693158388138,
-0.016094667837023735,
-0.006858042906969786,
0.028470538556575775,
0.014863117597997189,
-0.00036655968870036304,
0.0496966652572155,
0.06558607518672943,
0.04266958311200142,
0.017302069813013077,
0.017326217144727707,
0.0249690730124712,
-0.018738878890872,
0.0017492235638201237,
0.04677475243806839,
-0.05235294625163078,
-0.0035165580920875072,
-0.004213832784444094,
-0.06804917007684708,
-0.020489610731601715,
-0.005206920672208071,
0.007081412244588137,
-0.0018005381571128964,
-0.016831183806061745,
-0.005511790048331022,
-0.00115080492105335,
0.0021144626662135124,
-0.01232757419347763,
0.03979596868157387,
-0.06809747219085693,
0.05689277872443199,
-0.003643335308879614,
-0.0038516120985150337,
-0.010492322966456413,
-0.03272059187293053,
-0.014875192195177078,
0.02437744475901127,
0.005747233051806688,
-0.0559268593788147,
0.026683581992983818,
-0.032962072640657425,
0.02030850015580654,
0.05529901012778282,
0.028905201703310013,
0.0035950392484664917,
0.054671160876750946,
0.0066588218323886395,
0.029653791338205338,
-0.004207795951515436,
0.034483399242162704,
0.02030850015580654,
0.03185126185417175,
0.0062241568230092525,
0.0062422682531178,
0.007823964580893517,
-0.02649039775133133,
0.0019439171301200986,
0.02605573460459709,
0.020344723016023636,
-0.019753096625208855,
-0.03486976772546768,
0.00035505162668414414,
0.08113741129636765,
0.011995538137853146,
-0.0390956737101078,
0.007636817172169685,
-0.030281640589237213,
-0.024051446467638016,
0.02339944988489151,
0.018002362921833992,
0.00489299651235342,
-0.02145553193986416,
-0.022264491766691208,
0.04682304710149765,
0.00695463502779603,
0.017591847106814384,
0.028784461319446564,
0.032454963773489,
0.05901780724525452,
-0.022288639098405838,
0.00046409512287937105,
-0.05597515404224396,
-0.004690756555646658,
0.0033082813024520874,
-0.011440133675932884,
-0.05365694314241409,
-0.07838453352451324,
0.015563410706818104,
-0.008916663005948067,
-0.023170042783021927,
0.032913777977228165,
-0.0010957173071801662,
-0.013052014634013176,
0.03631864860653877,
0.01962028071284294,
0.05100065842270851,
0.05452627316117287,
-0.028132464736700058,
0.009641104377806187,
-0.050227921456098557,
-0.005318605341017246,
-0.01544267125427723,
-0.003045671386644244,
-0.01890791393816471,
-0.025934994220733643,
0.00918229203671217,
0.04827192798256874,
-0.02513810805976391,
0.011687650345265865,
0.004624349530786276,
0.014500897377729416,
0.03672916814684868,
-0.009158143773674965,
-0.01392134465277195,
-0.024051446467638016,
0.050469402223825455,
0.0028887090738862753,
0.03660842776298523,
-0.0262247696518898,
-0.004068944603204727,
0.017120959237217903,
-0.00811374094337225,
0.021636642515659332,
0.0024902664590626955,
0.03412117809057236,
-0.008270703256130219,
0.016903627663850784,
-0.047716524451971054,
-0.02399107627570629,
0.0384436771273613,
0.008512184023857117,
-0.04716112092137337,
-0.03199614956974983,
0.04293521121144295,
0.021600421518087387,
0.011162430979311466,
-0.004666608292609453,
-0.00470283068716526,
-0.04689549282193184,
0.013498753309249878,
-0.047571636736392975,
-0.018497398123145103,
0.04730600863695145,
0.03622205927968025,
0.007111597340553999,
-0.023097598925232887,
-0.007419485133141279,
0.01765221543610096,
-0.02641795389354229,
-0.02467929571866989,
-0.00735307764261961,
0.059355881065130234,
-0.018606062978506088,
-0.03774338588118553,
0.03648768737912178,
-0.02489662729203701,
0.024449888616800308,
0.027335580438375473,
0.05133873224258423,
-0.035932280123233795,
-0.023266635835170746,
-0.009918807074427605,
-0.039119821041822433,
0.04059285297989845,
0.037453606724739075,
-0.03499050810933113,
0.011838575825095177,
-0.03704309090971947,
0.026079881936311722,
-0.05525071173906326,
0.0019529726123437285,
0.004497572313994169,
0.0010760970180854201,
0.013172755017876625,
0.038733452558517456,
-0.027601208537817,
0.010896802879869938,
-0.019233912229537964,
-0.028373945504426956,
-0.012907126918435097,
-0.021515902131795883,
-0.00017629955254960805,
0.021564198657870293,
-0.0024766831193119287,
-0.019559910520911217,
0.024449888616800308,
0.005243143066763878,
0.023097598925232887,
0.028422242030501366,
0.009369439445436,
0.016951922327280045,
-0.011512577533721924,
0.027335580438375473,
-0.04247640073299408,
0.018400805070996284,
0.014645785093307495,
-0.062205348163843155,
0.0159860011190176,
-0.017567697912454605,
0.02798757702112198,
0.00882610771805048,
0.04059285297989845,
0.025596920400857925,
0.03192370757460594,
0.01826799102127552,
0.04252469539642334,
-0.01733829267323017,
0.03395214304327965,
0.013100311160087585,
-0.014694081619381905,
0.0138006042689085,
-0.004500590730458498,
-0.015164968557655811,
-0.03218933567404747,
-0.01817139983177185,
0.012665646150708199,
-0.018847543746232986,
-0.00226538791321218,
-0.0066588218323886395,
0.0013122949749231339,
-0.01843702793121338,
0.01893206313252449,
-0.013897196389734745,
0.005683844443410635,
-0.027069952338933945,
-0.03317940607666969,
-0.03506295382976532,
-0.06838724762201309,
0.009121921844780445,
-0.03776753321290016,
0.019233912229537964,
0.044625576585531235,
0.0073953368701040745,
-0.008608776144683361,
-0.0195478368550539,
0.01399378851056099,
-0.024389518424868584,
-0.0037308719474822283,
0.0032086707651615143,
-0.027311431244015694,
0.021841900423169136,
-0.00517371715977788,
0.007051227148622274,
0.04196929186582565,
0.00940566137433052,
0.006495822221040726,
0.019366726279258728,
-0.0162274818867445,
0.020900128409266472,
-0.03054726868867874,
0.00033052629441954195,
-0.010226694867014885,
0.011669539846479893,
0.018666433170437813,
-0.035811539739370346,
-0.021515902131795883,
0.005378975532948971,
-0.026635287329554558,
-0.020912202075123787,
0.007546262349933386,
0.008560479618608952,
-0.02905009128153324,
-0.018038585782051086,
-0.0014051139587536454,
-0.005333697889000177,
0.0036463539581745863,
-0.03680161014199257,
0.04216247424483299,
-0.00655619241297245,
-0.03899908438324928,
0.0021099348086863756,
-0.0441909097135067,
0.05597515404224396,
0.004950347822159529,
-0.046002015471458435,
-0.009828251786530018,
-0.0028917277231812477,
-0.020441314205527306,
0.010214620269834995,
0.00735307764261961,
0.014259416610002518,
0.011494466103613377,
0.013184829615056515,
-0.03252740949392319,
-0.003990463446825743,
-0.009532438591122627,
-0.006477711256593466,
0.008989107795059681,
0.012013649567961693,
-0.011337503790855408,
0.030281640589237213,
0.014512971043586731,
-0.01212835218757391,
0.0035739096347242594,
-0.013897196389734745,
-0.008554442785680294,
-0.015635855495929718,
-0.01167557667940855,
0.031440746039152145,
0.0188596174120903,
-0.03361406922340393,
-0.0409550741314888,
-0.018702656030654907,
0.02777024544775486,
-0.000035608925827546045,
-0.025548625737428665,
0.015973927453160286,
0.004938274156302214,
0.05863143876194954,
0.015804890543222427,
-0.03759849816560745,
-0.022385232150554657,
0.014730303548276424,
0.00726252282038331,
-0.02042924053966999,
-0.03187541291117668,
0.00918229203671217,
-0.04960007220506668,
-0.016879478469491005,
0.028639573603868484,
-0.0166742205619812,
0.021648716181516647,
0.004310424905270338,
-0.030354084447026253,
0.007473818026483059,
-0.0004135351628065109,
0.03518369421362877,
0.050565991550683975,
0.007522114086896181,
-0.01209213025867939,
-0.05167680233716965,
0.029629644006490707,
-0.025669366121292114,
-0.023182116448879242,
0.024546481668949127,
-0.013824752531945705,
-0.002069185022264719,
0.009369439445436,
0.033106960356235504,
0.02207130752503872,
-0.031368304044008255,
-0.01821969449520111,
0.038661010563373566,
0.02764950506389141,
0.005541974678635597,
-0.021057089790701866,
0.03656012937426567,
0.006429415196180344,
-0.02263878658413887,
-0.012919200584292412,
-0.001836760202422738,
-0.010540618561208248,
0.018992433324456215,
0.00479338550940156,
0.019113171845674515,
0.0003243006067350507,
0.05385012552142143,
0.03665672242641449,
-0.013716085813939571,
-0.0024857388343662024,
-0.006743339821696281,
-0.005641585681587458,
-0.03380725532770157,
0.009393586777150631,
-0.0024042390286922455,
0.012309462763369083,
-0.0016722517320886254,
0.018086880445480347,
0.025524476543068886,
0.018738878890872,
0.04440824314951897,
0.010510433465242386,
-0.0006976519362069666,
0.02145553193986416,
0.0182921402156353,
0.00008083933062152937,
-0.019801391288638115,
-0.008886477909982204,
0.0162274818867445,
0.002402729820460081,
-0.020489610731601715,
-0.02764950506389141,
0.008934774436056614,
-0.004687738139182329,
0.007371189072728157,
-0.01550304051488638,
0.011252986267209053,
-0.04387698695063591,
0.03235837072134018,
-0.008548405952751637,
-0.022433528676629066,
-0.010093879885971546,
0.010124064981937408,
0.018473248928785324,
-0.011011505499482155,
0.008795923553407192,
-0.012979570776224136,
0.004464368801563978,
0.04228321462869644,
0.013390087522566319,
-0.014017936773598194,
-0.020187759771943092,
-0.006308675277978182,
-0.030474824830889702,
-0.02349604107439518,
-0.026659434661269188,
0.029605494812130928,
0.04254884272813797,
0.008143926039338112,
-0.016408592462539673,
0.002226147335022688,
-0.029846975579857826,
-0.02791513316333294,
-0.006133602000772953,
-0.024643072858452797,
0.02926742285490036,
0.019849687814712524,
0.004020648542791605,
-0.017000218853354454,
-0.017084738239645958,
-0.010395730845630169,
0.0072564855217933655,
0.04667815938591957,
0.0586797334253788,
-0.04561564698815346,
0.034362658858299255,
-0.049117110669612885,
0.01991005800664425,
-0.0018563804915174842,
-0.0062241568230092525,
-0.013776456005871296,
-0.0037852050736546516,
-0.020223982632160187,
0.0008202787139452994,
-0.05389842391014099,
-0.018183473497629166,
0.003410910489037633,
-0.011796317063272,
0.030474824830889702,
-0.0768873542547226,
0.009176255203783512,
0.013438384048640728,
-0.004889977630227804,
0.01900450699031353,
0.017929919064044952,
0.008137889206409454,
-0.007636817172169685,
-0.050614289939403534,
-0.005200883839279413,
0.008850255981087685,
-0.016927774995565414,
0.015696225687861443,
0.010226694867014885,
-0.01198346447199583,
0.0010240278206765652,
-0.03653598204255104,
-0.018400805070996284,
0.005049958825111389,
-0.021697012707591057,
0.04665401205420494,
-0.008252591826021671,
-0.00479338550940156,
0.012273240834474564,
0.04662986472249031,
-0.015925630927085876,
0.004905070178210735,
-0.00818618480116129,
0.026635287329554558,
-0.002354433760046959,
-0.031392451375722885,
0.02435329742729664,
-0.032937925308942795,
0.006821820978075266,
0.01750732772052288,
-0.00439494289457798,
-0.002493285108357668,
-0.022771600633859634,
0.018738878890872,
0.02187812328338623,
-0.012593202292919159,
0.0015922612510621548,
-0.01240001805126667,
-0.014863117597997189,
-0.01601015031337738,
0.021986790001392365,
0.024051446467638016,
-0.003386762458831072,
-0.023640930652618408,
0.011838575825095177,
0.010250842198729515,
-0.02062242478132248,
0.015515115112066269,
-0.008783848956227303,
0.027552912011742592,
0.031320005655288696,
-0.07355492562055588,
-0.02936401590704918,
0.003368651494383812,
0.001974102109670639,
-0.015841113403439522,
-0.01198346447199583,
-0.030257493257522583,
0.021684939041733742,
0.025500329211354256,
-0.009272847324609756,
-0.014078306965529919,
-0.008989107795059681,
0.03774338588118553,
-0.008318999782204628,
-0.006012861616909504,
0.013824752531945705,
-0.026780175045132637,
-0.021515902131795883,
0.0007006704108789563,
0.0195478368550539,
-0.00796885322779417,
0.03962692990899086,
-0.011965353041887283,
0.02801172435283661,
-0.0008625377668067813,
0.01846117526292801,
-0.018086880445480347,
-0.005680826026946306,
-0.0004301369481254369,
-0.004551905207335949,
-0.028687870129942894,
0.004736034199595451,
0.0007719825953245163,
0.04392528161406517,
-0.021793605759739876,
-0.021008793264627457,
0.028856907039880753,
-0.019849687814712524,
-0.002789098536595702,
-0.017845401540398598,
0.018328361213207245,
0.0024298964999616146,
0.04218662530183792,
0.029750384390354156,
-0.020175686106085777,
-0.01637236960232258,
-0.024461964145302773,
0.006024935748428106,
-0.004280239809304476,
-0.03240666911005974,
0.03663257509469986,
-0.041582923382520676,
-0.05278761312365532,
-0.008276740089058876,
-0.0029656810220330954,
-0.025355441495776176,
0.011585021391510963,
0.045881275087594986,
0.015792816877365112,
-0.01733829267323017,
-0.0011123190633952618,
0.01686740480363369,
0.04918955639004707,
0.000513900478836149,
0.010087843053042889,
-0.02411181665956974,
-0.0333484411239624,
0.06655199825763702,
-0.026683581992983818,
0.009532438591122627,
-0.00994295533746481,
0.012713942676782608,
-0.05457456782460213,
0.02798757702112198,
-0.014512971043586731,
0.013257273472845554,
-0.0018760007806122303,
-0.015841113403439522,
-0.02099671959877014,
0.019390875473618507,
-0.018666433170437813,
0.0059887138195335865,
0.0290983859449625,
0.008469924330711365,
-0.03767094016075134,
0.012569054029881954,
-0.0023483966942876577,
0.006375082302838564,
0.005958528723567724,
0.0007727372576482594,
0.0020133426878601313,
-0.01217664871364832,
0.0026457195635885,
0.011977427639067173,
0.0048688482493162155,
-0.0021521940361708403,
-0.006012861616909504,
0.017845401540398598,
0.020006651058793068,
-0.002198980888351798,
0.08026807755231857,
-0.013752307742834091,
-0.020236056298017502,
-0.01254490576684475,
-0.002977754920721054,
0.007667002268135548,
0.02118990384042263,
-0.03274473920464516,
0.007775668520480394,
-0.006465637590736151,
0.019354652613401413,
-0.008729515597224236,
0.003773131174966693,
-0.01197138987481594,
0.014356008730828762,
-0.012532832100987434,
0.015829039737582207,
0.004138370044529438,
0.016589703038334846,
-0.019849687814712524,
0.06331615895032883,
0.012822608463466167,
0.010262916795909405,
0.0056596966460347176,
0.014005862176418304,
0.03501465544104576,
0.0057653444819152355,
0.025886697694659233,
0.016758738085627556,
-0.01601015031337738,
-0.007787742651998997,
0.018497398123145103,
0.0347248800098896,
0.006604488473385572,
-0.025500329211354256,
0.021165756508708,
0.0006225666147656739,
0.018545694649219513,
0.023882409557700157,
0.009459993802011013,
0.02435329742729664,
-0.02791513316333294,
0.010812284424901009,
-0.028929350897669792,
0.015684152022004128,
-0.005297475960105658,
-0.06529629975557327,
-0.005970602389425039,
-0.023834114894270897,
-0.017326217144727707,
-0.010884728282690048,
0.013631568290293217,
0.04716112092137337,
0.020900128409266472,
-0.003486372996121645,
0.011560873128473759,
0.009019292891025543,
-0.0069485981948673725,
-0.010480249300599098,
-0.025814253836870193,
-0.012907126918435097,
0.007552299182862043,
-0.028687870129942894,
-0.013100311160087585,
0.014440527185797691,
-0.018823396414518356,
-0.016529332846403122,
0.007896408438682556,
0.057762108743190765,
0.023194191977381706,
-0.003887834260240197,
-0.06008031964302063,
0.01893206313252449,
0.008288814686238766,
-0.03808145597577095,
0.022336935624480247,
0.04822363331913948,
-0.0029762457124888897,
0.023242486640810966,
0.03561835736036301,
-0.038854192942380905,
0.012532832100987434,
0.010462137870490551,
0.031175117939710617,
0.0340728834271431,
-0.02320626564323902,
0.031175117939710617,
-0.018726803362369537,
0.013679863885045052,
-0.013088236562907696,
-0.021165756508708,
-0.020272279158234596,
0.025452032685279846,
0.04704038053750992,
0.010287064127624035,
-0.005913251079618931,
-0.02195056714117527,
0.007938668131828308,
-0.05302909389138222,
-0.012810534797608852,
-0.042983509600162506,
0.023266635835170746,
0.03692235052585602,
0.011609169654548168,
-0.029846975579857826,
0.00653808144852519,
-0.005695918574929237,
-0.012424166314303875,
-0.03486976772546768,
0.030329937115311623,
-0.010130101814866066,
0.06481333822011948,
-0.034604139626026154,
0.024558555334806442,
0.03953034058213234,
-0.009411698207259178,
-0.001898639602586627,
0.016311999410390854,
-0.044625576585531235,
0.006411304231733084,
0.0005440855165943503,
-0.025838401168584824,
-0.0188596174120903,
0.04076188802719116,
0.007528150919824839,
0.028132464736700058,
0.04039967060089111,
-0.01962028071284294,
-0.023085525259375572,
0.02946060709655285,
-0.006622599437832832,
0.023001007735729218,
0.00626037921756506,
0.012170611880719662,
-0.0054634939879179,
0.003649372374638915,
-0.007045190315693617,
-0.037187978625297546,
0.034290216863155365,
-0.0017703530611470342,
0.04068944603204727,
0.028373945504426956,
-0.027069952338933945,
-0.015587558969855309,
-0.025717660784721375,
-0.00014847271086182445,
0.04426335543394089,
-0.031561486423015594,
-0.026007438078522682,
-0.013691937550902367,
-0.011005468666553497,
-0.008488035760819912,
0.023677151650190353,
0.03180296719074249,
0.04279032349586487,
0.01981346495449543,
0.010268953628838062,
0.020127389580011368,
0.04146218299865723,
-0.007069338578730822,
0.026659434661269188,
-0.027287283912301064,
0.012460388243198395,
-0.01881132274866104,
0.004932236857712269,
-0.02612817846238613,
-0.001821667654439807,
-0.0111080976203084,
0.015998074784874916,
0.006598451640456915,
-0.010504396632313728,
0.003872741712257266,
-0.011434095911681652,
-0.005496697500348091,
0.011989501304924488,
-0.013510827906429768,
0.031416598707437515,
-0.04056870564818382,
-0.02352019026875496,
0.0064475261606276035,
0.003278096206486225,
0.006350934039801359,
-0.0019348616478964686,
-0.003202633699402213,
-0.0009629030246287584,
0.016432739794254303,
-0.016324074938893318,
-0.021008793264627457,
0.031706374138593674,
-0.040472112596035004,
0.0021869067568331957,
0.0031271709594875574,
-0.004521720111370087,
0.016070520505309105,
-0.0176039207726717,
-0.020344723016023636,
-0.018026510253548622,
0.00001077111028280342,
-0.01103565376251936,
-0.02413596399128437,
0.04151047766208649,
0.025548625737428665,
-0.013619493693113327,
-0.0022382212337106466,
0.02905009128153324,
-0.009411698207259178,
-0.04662986472249031,
-0.035739097744226456,
0.04979325458407402,
-0.026900915428996086,
-0.049213703721761703,
0.008119777776300907,
0.028567129746079445,
0.007576446980237961,
0.004684719722718,
-0.0013787021161988378,
-0.014174899086356163,
0.005508771166205406,
-0.02475173957645893,
0.006200009025633335,
0.007552299182862043,
0.031537339091300964,
0.007039153482764959,
-0.023979002609848976,
-0.029822828248143196,
-0.015865260735154152,
0.005134476814419031,
-0.009423771873116493,
0.008192222565412521,
-0.012762238271534443,
0.000046551005652872846,
0.009622993879020214,
-0.007980926893651485,
-0.018642285838723183,
0.03684990853071213,
0.02926742285490036,
0.01031121239066124,
0.007811890449374914,
-0.025934994220733643,
0.0027724967803806067,
0.010564766824245453,
-0.01163935475051403,
-0.0005414442857727408,
0.008524257689714432,
0.024715518578886986,
0.019970428198575974,
0.006743339821696281,
0.011246949434280396,
-0.04334573075175285,
-0.034193623811006546,
0.05071088299155235,
0.011917057447135448,
-0.017422810196876526,
0.059597358107566833,
0.005720066837966442,
0.0009500744054093957,
0.004998643882572651,
0.03467658534646034,
0.005505752749741077,
-0.01991005800664425,
-0.01846117526292801,
0.023182116448879242,
0.04931029677391052,
0.0025898772291839123,
-0.0002818529028445482,
-0.0028041910845786333,
-0.008343147113919258,
-0.015973927453160286,
-0.015056301839649677,
-0.03380725532770157,
0.006459600292146206,
0.025427885353565216,
-0.007371189072728157,
0.013583271764218807,
0.004959403537213802,
0.04549490660429001,
0.05814847722649574,
0.005557067226618528,
-0.01983761414885521,
0.022385232150554657,
-0.0046967933885753155,
-0.002051074057817459,
-0.0058166589587926865,
-0.021552124992012978,
-0.01125902310013771,
-0.007455707062035799,
-0.01471822988241911,
0.005638567265123129,
-0.0030471805948764086,
0.010800210759043694,
-0.015756595879793167,
-0.01905280351638794,
0.028712017461657524,
-0.01376438234001398,
-0.027311431244015694,
-0.0033565773628652096,
0.009900695644319057,
0.004745089448988438,
-0.03317940607666969,
-0.010721729137003422,
-0.01581696607172489,
-0.004005555994808674,
0.017615994438529015,
-0.0028132465668022633,
0.007196115329861641,
0.00397838931530714,
0.011059802025556564,
0.03506295382976532,
0.008240518160164356,
-0.002592895645648241,
-0.025331292301416397,
-0.018545694649219513,
-0.056313227862119675,
0.0384436771273613,
-0.0060007874853909016,
-0.01738658733665943,
0.01470615528523922,
-0.00764285447075963,
0.0004980533267371356,
-0.005475567653775215,
-0.013752307742834091,
-0.01843702793121338,
-0.007365151774138212,
0.0382021963596344,
-0.008989107795059681,
0.017785031348466873,
0.017664290964603424,
0.014476749114692211,
-0.031175117939710617,
0.005028828978538513,
0.01130731962621212,
0.004111203830689192,
-0.005569141358137131,
-0.03218933567404747,
-0.01312445942312479,
0.02629721350967884,
0.016637999564409256,
0.009622993879020214,
-0.032768890261650085,
0.015370226465165615,
0.02620062232017517,
0.014368083328008652,
0.021503828465938568,
0.0063811191357672215,
0.0020872962195426226,
-0.0204775370657444,
0.009296994656324387,
-0.010359508916735649,
-0.0006957653677091002,
0.014887265861034393,
0.004222888499498367,
0.010957172140479088,
-0.003610131796449423,
0.007111597340553999,
-0.04650912433862686,
0.0028811627998948097,
-0.03803316131234169,
0.020586203783750534,
0.011772168800234795,
0.02917083166539669,
-0.03701894357800484,
-0.004240999463945627,
0.01981346495449543,
-0.004280239809304476,
-0.01755562424659729,
0.009876548312604427,
0.0016767794732004404,
-0.023157969117164612,
-0.01836458407342434,
-0.010468174703419209,
-0.004859792999923229,
0.0111080976203084,
0.0025717660319060087,
-0.0022819896694272757,
0.016070520505309105,
-0.02506566420197487,
0.03194785490632057,
0.009804103523492813,
-0.013293495401740074,
0.002911347895860672,
0.005375957116484642,
0.021346867084503174,
0.003214707598090172,
0.006254341918975115,
0.005055995658040047,
0.020610351115465164,
-0.010884728282690048,
-0.03390384465456009,
0.04390113428235054,
0.028712017461657524,
0.009508290328085423,
0.014259416610002518,
-0.010075769387185574,
-0.013414235785603523,
0.017422810196876526,
0.011754058301448822,
-0.011096023954451084,
-0.01098735723644495,
-0.0036946500185877085,
0.02506566420197487,
-0.007830001413822174,
0.008168074302375317,
-0.0030939674470573664,
-0.01637236960232258,
-0.010794172994792461,
0.00769718736410141,
-0.028349798172712326,
-0.0886233001947403,
-0.016022223979234695,
0.011102060787379742,
-0.015189116820693016,
0.016142964363098145,
-0.0067252288572490215,
0.0009259263752028346,
0.033106960356235504,
-0.01387304812669754,
-0.0354493223130703,
0.0494551844894886,
-0.00653808144852519,
-0.015189116820693016,
0.00775152025744319,
0.027287283912301064,
0.002327267313376069,
-0.019535763189196587,
-0.015539263375103474,
-0.014983857981860638,
0.009828251786530018,
0.015720373019576073,
0.002298591425642371,
0.017640141770243645,
0.03513539582490921,
0.0219747144728899,
0.011621243320405483,
0.025210551917552948,
-0.017048515379428864,
0.0347248800098896,
-0.011874797753989697,
-0.007799816317856312,
0.00838540680706501,
0.024051446467638016,
-0.005973621271550655,
0.0048024412244558334,
0.005306531675159931,
-0.0012089111842215061,
0.027287283912301064,
0.02919497899711132,
0.0030818935483694077,
-0.02649039775133133,
0.006731265690177679,
0.01848532445728779,
0.016360295936465263,
-0.008892515674233437,
-0.010679470375180244,
-0.011422022245824337,
0.0010217638919129968,
-0.0032901703380048275,
-0.003510521026328206,
-0.012653572484850883,
-0.017024368047714233,
0.044601429253816605,
0.05104895308613777,
-0.02905009128153324,
0.019342578947544098,
0.004563979338854551,
-0.009508290328085423,
0.005596308037638664,
-0.013498753309249878,
-0.014307713136076927,
-0.02259049005806446,
-0.004545868374407291,
-0.005674789194017649,
-0.026031585410237312,
0.009140032343566418,
-0.03979596868157387,
-0.004159499891102314,
0.03651183471083641,
-0.0073228925466537476,
-0.0015235902974382043,
-0.031295858323574066,
-0.02762535586953163,
0.0028947461396455765,
0.028736166656017303,
-0.03093363717198372,
-0.006344897206872702,
0.00041693096864037216,
0.004476442467421293,
-0.02605573460459709,
-0.003444114001467824,
0.005016754847019911,
-0.009242662228643894,
-0.03513539582490921,
-0.016094667837023735,
0.006827857811003923,
0.01250868383795023,
0.013583271764218807,
0.0030517084524035454,
0.021793605759739876,
-0.02943645976483822,
-0.010848506353795528,
-0.009707511402666569,
0.011844612658023834,
0.0033324293326586485,
-0.035859838128089905,
-0.02320626564323902,
0.032986219972372055,
-0.004790367092937231,
-0.017302069813013077,
-0.01917354203760624,
-0.0015681132208555937,
0.01254490576684475,
-0.03209274262189865,
-0.0065018595196306705,
-0.02506566420197487,
0.02506566420197487,
0.0065863775089383125,
0.02349604107439518,
-0.027311431244015694,
0.021938493475317955,
-0.01966857723891735,
0.022421453148126602,
0.03180296719074249,
0.026876768097281456,
-0.007552299182862043,
-0.016191260889172554,
0.024582702666521072,
0.028494685888290405,
-0.002122008940204978,
0.0007497211336158216,
0.018581915646791458,
-0.007473818026483059,
-0.010244805365800858,
0.012786386534571648,
0.025548625737428665,
-0.01463371142745018,
-0.04486705735325813,
-0.0023333041463047266,
-0.018799249082803726,
0.010208583436906338,
-0.028398092836141586,
0.01838873140513897,
0.028301501646637917,
0.0072564855217933655,
-0.02175738289952278,
-0.012086093425750732,
-0.038516122847795486,
0.014319786801934242,
-0.0480787456035614,
-0.03660842776298523,
0.009176255203783512,
-0.03619791194796562,
-0.020236056298017502,
0.0031030229292809963,
0.010631173849105835,
-0.021769456565380096,
0.02938816323876381,
-0.0006497331778518856,
0.00510127330198884,
-0.02192641980946064,
0.0025612013414502144,
0.007304781582206488,
-0.010027472861111164,
-0.02941231057047844,
0.00303510669618845,
0.02929157018661499,
-0.00487488554790616,
-0.02504151687026024,
0.028229057788848877,
0.01679496094584465,
-0.04349061846733093,
-0.014162824489176273,
-0.044577278196811676,
0.004814515355974436,
-0.018207620829343796,
0.009683363139629364,
0.1308823674917221,
-0.02632136270403862,
0.037477757781744,
0.002416313160210848,
-0.01625162921845913,
-0.022916488349437714,
0.02344774641096592,
-0.0031090599950402975,
0.006375082302838564,
-0.016662146896123886,
0.030257493257522583,
-0.0003392044745851308,
0.01952368952333927,
0.006930487230420113,
0.03902323171496391,
-0.005877029150724411,
0.01826799102127552,
0.02021190896630287,
-0.02437744475901127,
-0.005279364995658398,
-0.019318431615829468,
0.007135745603591204,
-0.022723304107785225,
0.03542517125606537,
-0.017495254054665565,
0.018871692940592766,
-0.01307616289705038,
-0.04194514453411102,
0.027432171627879143,
-0.021600421518087387,
0.03226178139448166,
-0.011838575825095177,
0.010600988753139973,
-0.040254779160022736,
0.02467929571866989,
-0.005701955873519182,
-0.004313443321734667,
-0.02111745998263359,
-0.001717529259622097,
0.014259416610002518,
0.007202152628451586,
-0.005551030393689871,
-0.01392134465277195,
0.013643641956150532,
0.021515902131795883,
0.012798460200428963,
-0.017688438296318054,
-0.004084037151187658,
0.021515902131795883,
-0.004742071032524109,
0.01390927005559206,
-0.010015399195253849,
0.0166742205619812,
0.002022398170083761,
-0.02487247996032238,
-0.017205476760864258,
0.025476180016994476,
0.004905070178210735,
-0.007371189072728157,
-0.038781750947237015,
-0.0028238112572580576,
0.00009555454744258896,
-0.011023580096662045,
-0.02661113813519478,
0.010697580873966217
] | 2025-01-16 | 37 | 39815137 | [
"chemokine receptors",
"tumor tissues",
"T cells",
"chemokine secretion",
"adoptive cell therapy",
"increased chemokine levels",
"immune cells",
"cell trafficking",
"cell migration",
"cell viability",
"different tumor types",
"solid tumors",
"normal tissues",
"chimeric antigen receptor-T cells",
"the appropriate chemokine receptors",
"cancer therapy outcomes",
"candidates",
"elevated expression",
"eight chemokine receptors",
"five chemokine receptors",
"extensive RNA",
"ACT",
"valuable targets",
"both tumor tissues",
"the eight candidate chemokine receptors",
"CXCR5",
"tumor-infiltrating lymphocytes",
"Subsequent examination",
"RNA",
"data"
] | [
"Adoptive cell therapy",
"Chemokine",
"Chemokine receptor",
"Immune cell trafficking"
] | 0 | 10.1007/s12026-024-09560-y
10.1186/s13045-023-01492-8
10.1007/s00428-018-2484-0
10.1038/s41419-017-0238-6
10.1038/nm.4015
10.1158/1078-0432.CCR-06-1183
10.1158/2159-8290.CD-19-0790
10.1016/j.xcrm.2022.100543
10.1084/jem.187.4.655
10.1038/35876
10.1038/s41467-019-11869-4
10.3389/fimmu.2021.628906
10.1038/s41551-021-00737-6
10.1158/2159-8290.CD-12-0548
10.1186/s13287-020-02128-1
10.1038/s41375-023-01976-z
10.3389/fimmu.2018.00947
10.1200/JCO.2010.32.2537
10.18632/oncotarget.23007
10.1007/s00262-020-02633-5
10.1016/j.omto.2022.04.003
10.1002/advs.202103508
10.1038/s41467-020-20696-x
10.1038/s41591-020-1074-2
10.1002/eji.201948457
10.1080/2162402X.2018.1450715
10.1016/j.omto.2019.12.006
10.1016/j.scib.2020.12.021
10.1038/s41417-021-00365-x
10.1016/j.bcp.2023.115536
10.3389/fgene.2019.01245
10.1371/journal.pone.0176185
10.1016/j.omto.2021.07.003
10.1006/cyto.2001.0923
10.3389/fendo.2019.00471
10.1016/j.lfs.2019.04.053
10.21037/jtd.2017.03.61 | [
"Han",
"Jeong",
"Hong",
"Seo",
"Lee",
"Kim",
"Hong",
"Lee",
"Cha",
"Kim",
"Park",
"Gong",
"Lee"
] | [
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea.\nBiomedical Sciences, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul, South Korea.",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea.",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea.\nBiomedical Sciences, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul, South Korea.",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea.\nNeogenTC Corp, Seoul, Korea.\nBiomedical Sciences, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul, South Korea.",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea.",
"NeogenTC Corp, Seoul, Korea.",
"NeogenTC Corp, Seoul, Korea.",
"NeogenTC Corp, Seoul, Korea.",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea.\nBiomedical Sciences, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul, South Korea.",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea.\nBiomedical Sciences, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul, South Korea.",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea.\nBiomedical Sciences, Asan Medical Institute of Convergence Science and Technology, University of Ulsan College of Medicine, Seoul, South Korea.",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea. [email protected].",
"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro, 43-Gil, Songpa-Gu, Seoul, 05505, Korea. [email protected].\nNeogenTC Corp, Seoul, Korea. [email protected]."
] | [
"39815137",
"37596653",
"30470934",
"29415996",
"26735408",
"17062687",
"31974169",
"35492880",
"9463416",
"9486651",
"31488817",
"33777013",
"34083764",
"23550147",
"33494834",
"37626090",
"29770138",
"21282551",
"29371915",
"32529292",
"35572194",
"35032108",
"33462245",
"33046868",
"31981231",
"30221044",
"31970285",
"36654130",
"34471234",
"37028461",
"31867042",
"28459823",
"34553036",
"11554781",
"31354634",
"31026453",
"28446981"
] | [] | 9.815993 | 5.05102 |
39815015 | 25 | Donor-derived GD2-specific CAR T cells in relapsed or refractory neuroblastoma. | Allogeneic chimeric antigen receptor (CAR) T cells targeting disialoganglioside-GD2 (ALLO_GD2-CART01) could be a therapeutic option for patients with relapsed or refractory, high-risk neuroblastoma (r/r HR-NB) whose tumors did not respond to autologous GD2-CART01 or who have profound lymphopenia. We present a case series of five children with HR-NB refractory to more than three different lines of therapy who received ALLO_GD2-CART01 in a hospital exemption setting. Four of them had previously received allogeneic hematopoietic stem cell transplantation. All patients experienced grade 2 or 3 cytokine release syndrome and one grade 2 neurotoxicity. Moderate acute graft-versus-host-disease occurred in four patients. ALLO_GD2-CART01 persisted for >6 weeks. Post-treatment, two complete responses were achieved and one maintained; in addition, one partial response and one stable disease were observed. Comparing the transcriptomic profiles obtained by RNA sequencing analyses of drug products with patient-matched, peripheral blood ALLO_GD2-CART01 collected at expansion, we found upregulation of genes associated with T cell activation and migration. In addition, after infusion, transcriptomic signaling analysis showed enrichment of genes involved in response to decreased oxygen levels, humoral immune response, cell polarization and immune-synapse formation. In comparison to autologous CAR T cells, ALLO_GD2-CAR T cells were characterized by pathways associated with T cell proliferation, immune-synapse formation and cell chemotaxis. The safety and efficacy of ALLO_GD2-CART01 in children with r/r HR-NB deserve further investigation in a prospective trial. | [
0.007427464704960585,
0.023259535431861877,
0.05045161023736,
0.05841260403394699,
-0.029254259541630745,
-0.04635121673345566,
-0.030836867168545723,
0.03476940840482712,
0.002277995692566037,
-0.021353211253881454,
0.004211294464766979,
-0.025489572435617447,
-0.032203663140535355,
0.00827272143214941,
0.020370077341794968,
-0.028367040678858757,
0.06234514340758324,
-0.022060589864850044,
0.027264010161161423,
0.009765408001840115,
0.04016466066241264,
0.021425148472189903,
-0.0016875151777639985,
-0.0059527624398469925,
-0.0090400455519557,
-0.023595239967107773,
0.05548717826604843,
-0.0022015629801899195,
0.03553673252463341,
-0.0435456857085228,
0.007541364524513483,
-0.005943770054727793,
-0.0038156427908688784,
0.004535009618848562,
-0.01585005410015583,
0.02752777934074402,
0.05970746651291847,
0.0008482536650262773,
-0.02306770347058773,
-0.01230117678642273,
0.030740952119231224,
-0.009183919057250023,
0.029206302016973495,
0.07385502010583878,
-0.04836544394493103,
0.0011374991154298186,
0.0008175306720659137,
-0.029038449749350548,
0.021964672952890396,
-0.01156982034444809,
-0.02027416042983532,
0.018523700535297394,
-0.02317560836672783,
0.053856611251831055,
-0.037886664271354675,
0.03831828385591507,
-0.004094397649168968,
-0.001802913611754775,
0.02395492233335972,
0.005970746278762817,
0.008812245912849903,
-0.018223965540528297,
0.047286394983530045,
-0.021521063521504402,
-0.026904327794909477,
-0.03659180551767349,
-0.10023181140422821,
-0.04390536993741989,
0.02666453830897808,
0.032179687172174454,
-0.011126209981739521,
-0.014243467710912228,
0.02106546424329281,
-0.05246583744883537,
-0.001526406966149807,
0.03251539170742035,
-0.001478449092246592,
0.013248343020677567,
0.014591161161661148,
-0.013284311629831791,
-0.0019722646102309227,
0.017552556470036507,
0.007727201096713543,
-0.051554638892412186,
0.009567582048475742,
-0.035081133246421814,
0.020789707079529762,
-0.042298782616853714,
-0.019051237031817436,
-0.015694191679358482,
-0.010622653178870678,
-0.00148369453381747,
-0.04915674775838852,
0.06435937434434891,
-0.022648071870207787,
-0.009345777332782745,
0.027072180062532425,
-0.02390696480870247,
0.053856611251831055,
0.022875871509313583,
0.016881147399544716,
-0.011767646297812462,
0.021497085690498352,
-0.016953082755208015,
0.035728562623262405,
0.05495964363217354,
-0.04045240581035614,
0.01737271435558796,
0.03529694303870201,
-0.02387099713087082,
0.05203421786427498,
-0.008380626328289509,
-0.005347295198589563,
0.04184318333864212,
-0.012349134311079979,
-0.07687635719776154,
-0.05908401310443878,
-0.06766846030950546,
0.007835105992853642,
0.0505475252866745,
-0.05141076445579529,
0.03491327911615372,
0.022048600018024445,
-0.0433058962225914,
-0.005554113071411848,
0.009855328127741814,
0.05251379311084747,
-0.01051474828273058,
-0.0217608530074358,
-0.023655185475945473,
0.025489572435617447,
0.008458557538688183,
-0.024842141196131706,
-0.03666374087333679,
-0.07145712524652481,
-0.0009808869799599051,
-0.0363280363380909,
-0.04404924064874649,
-0.04392934590578079,
0.010592679493129253,
0.006953881587833166,
-0.05424027517437935,
-0.01883542723953724,
0.000006211331765371142,
-0.030453205108642578,
-0.01013708021491766,
0.02008233033120632,
0.024062827229499817,
0.01724082976579666,
0.03158021345734596,
-0.07457438111305237,
0.06958676874637604,
0.010292943567037582,
-0.0018193991854786873,
0.015190633945167065,
-0.057501405477523804,
-0.00795500073581934,
0.04261050745844841,
-0.032179687172174454,
-0.033522505313158035,
-0.012732796370983124,
0.006528255995362997,
-0.01558628585189581,
-0.030453205108642578,
0.002496803179383278,
0.013500121422111988,
-0.019159141927957535,
0.021964672952890396,
-0.05865239351987839,
0.030860846862196922,
0.009447687305510044,
-0.0017879268852993846,
-0.07097754627466202,
-0.012199265882372856,
-0.029877711087465286,
-0.013727921061217785,
0.01046079583466053,
0.013883784413337708,
-0.013152427971363068,
-0.0035338907036930323,
0.035009197890758514,
0.0019288029288873076,
0.027623694390058517,
-0.009333787485957146,
-0.052369922399520874,
0.030501162633299828,
-0.007637280039489269,
-0.0006781533011235297,
-0.053760696202516556,
0.029254259541630745,
0.058844223618507385,
-0.030740952119231224,
0.052369922399520874,
-0.019243068993091583,
0.0003741083201020956,
-0.07073775678873062,
0.04817361384630203,
0.025753339752554893,
-0.05692591145634651,
-0.06997043639421463,
0.03534490242600441,
-0.04052434489130974,
-0.031388383358716965,
-0.030501162633299828,
-0.035728562623262405,
0.007001839112490416,
-0.002402386162430048,
0.015274560078978539,
0.010982336476445198,
-0.03522500768303871,
0.0432819165289402,
0.024698268622159958,
-0.035752542316913605,
0.04112381488084793,
-0.024938058108091354,
-0.04973224177956581,
-0.03414595499634743,
0.0252018254250288,
0.03843817859888077,
0.006750060711055994,
-0.013128448277711868,
0.028678765520453453,
-0.0645991638302803,
0.015226602554321289,
-0.020669812336564064,
-0.0032101755496114492,
0.02807929366827011,
-0.016437536105513573,
-0.013919752091169357,
-0.03306690603494644,
0.0011270083487033844,
0.038701947778463364,
0.023619217798113823,
-0.04193909838795662,
-0.01411158312112093,
-0.0007040055352263153,
0.044504839926958084,
0.005943770054727793,
0.047238435596227646,
-0.03196387737989426,
-0.001981256762519479,
0.010023180395364761,
0.006977860350161791,
-0.016149790957570076,
-0.014926866628229618,
-0.028319083154201508,
-0.019758615642786026,
-0.05467189475893974,
0.0645032450556755,
-0.004040444735437632,
-0.050259776413440704,
0.014219488948583603,
0.02297178842127323,
-0.039349377155303955,
0.003950524143874645,
0.014255456626415253,
0.040140680968761444,
-0.022096557542681694,
-0.03030933067202568,
-0.008788267150521278,
0.0015421430580317974,
-0.021820800378918648,
-0.0051614586263895035,
-0.030932782217860222,
-0.031292468309402466,
0.03026137314736843,
0.021101433783769608,
0.0035728563088923693,
-0.010256974957883358,
0.03316282108426094,
0.018283912912011147,
-0.026160981506109238,
0.015610264614224434,
-0.021089443936944008,
-0.03910958766937256,
-0.002541763475164771,
0.004190313164144754,
0.03026137314736843,
-0.007241628132760525,
0.0004016465973109007,
0.006336424965411425,
0.03174806386232376,
-0.004223283845931292,
-0.04982815682888031,
-0.03397810459136963,
0.032203663140535355,
0.00830868910998106,
0.006228519603610039,
-0.05189034342765808,
-0.02369115501642227,
0.003458956489339471,
-0.006528255995362997,
0.03033331036567688,
-0.03460155427455902,
0.0020756737794727087,
-0.019123174250125885,
0.006708097644150257,
0.004852730315178633,
0.004759811796247959,
0.03822236880660057,
-0.025393657386302948,
0.029470069333910942,
-0.014279436320066452,
0.006540245376527309,
0.004091400187462568,
0.011156183667480946,
-0.008830230683088303,
0.01474702451378107,
-0.003842619014903903,
0.034361764788627625,
0.013883784413337708,
0.00484074093401432,
0.006063664797693491,
0.009088004007935524,
0.004250260069966316,
-0.01666533574461937,
0.01866757497191429,
-0.0359683521091938,
-0.0004432350106071681,
-0.0032191674690693617,
-0.02449444867670536,
-0.02608904428780079,
-0.004055431578308344,
-0.011060268618166447,
-0.021257296204566956,
-0.015022781677544117,
0.026113023981451988,
0.009076014161109924,
0.03301894664764404,
-0.034313809126615524,
-0.011941492557525635,
-0.037239234894514084,
0.05855647847056389,
0.00489769084379077,
0.027983378618955612,
-0.012624891474843025,
0.006881944835186005,
-0.031244508922100067,
0.028007356449961662,
-0.02094557136297226,
0.01957877352833748,
0.0217488631606102,
-0.0503077358007431,
-0.011228120885789394,
-0.009028056636452675,
-0.02086164429783821,
-0.02733594737946987,
0.04133962467312813,
-0.009213892742991447,
0.020645834505558014,
-0.001891335821710527,
-0.023595239967107773,
-0.00827272143214941,
0.027623694390058517,
0.00003526584623614326,
0.03225162252783775,
-0.016857167705893517,
0.02016625553369522,
0.014039646834135056,
0.034889303147792816,
0.01267284993082285,
0.037239234894514084,
-0.0361122265458107,
0.054575979709625244,
0.07155304402112961,
0.05558309331536293,
-0.026928305625915527,
0.034961238503456116,
-0.007055791560560465,
-0.04030853509902954,
-0.018931342288851738,
-0.01553832832723856,
0.011090242303907871,
0.0363040566444397,
-0.043713536113500595,
0.028726724907755852,
0.01552633848041296,
-0.003141236025840044,
0.006162577774375677,
0.007265607360750437,
0.03510511294007301,
-0.03018943779170513,
-0.01008912269026041,
-0.06421549618244171,
-0.01191751379519701,
0.02310367114841938,
0.036495886743068695,
-0.017480619251728058,
-0.055151473730802536,
0.021964672952890396,
0.015466391108930111,
-0.02810327336192131,
0.007103749550879002,
0.015382464975118637,
-0.04119575396180153,
0.05500759929418564,
0.0034109987318515778,
0.07342339307069778,
0.045152273029088974,
0.029422111809253693,
-0.01296059601008892,
-0.050259776413440704,
-0.02745584212243557,
-0.0433538556098938,
0.008158821612596512,
-0.006366398185491562,
-0.0028385024052113295,
0.030908804386854172,
0.03822236880660057,
-0.03026137314736843,
-0.0361362062394619,
0.01474702451378107,
0.029278239235281944,
-0.020489972084760666,
0.038630008697509766,
-0.020358087494969368,
-0.06119415536522865,
0.05865239351987839,
-0.022132525220513344,
0.06790824979543686,
0.05217808857560158,
-0.016401568427681923,
0.008296700194478035,
-0.03311486169695854,
-0.017708418890833855,
-0.0434497706592083,
0.02299576625227928,
0.012732796370983124,
0.001617077155970037,
-0.057405490428209305,
-0.014003678224980831,
0.05846056342124939,
-0.016125811263918877,
-0.04963632673025131,
0.00648629292845726,
0.047166500240564346,
-0.020669812336564064,
0.03958916664123535,
-0.02084965445101261,
0.03476940840482712,
-0.001013857894577086,
0.005772920325398445,
-0.03026137314736843,
-0.03189193829894066,
0.01411158312112093,
0.00008378565689781681,
-0.01595795899629593,
0.021377190947532654,
-0.050787314772605896,
-0.022588124498724937,
-0.015742149204015732,
-0.006875949911773205,
0.018535690382122993,
0.0034319802653044462,
-0.0179961659014225,
-0.02014227770268917,
0.014723045751452446,
-0.058172814548015594,
-0.0030902810394763947,
0.049396537244319916,
0.04241867735981941,
-0.006390377413481474,
-0.016977062448859215,
0.005533131305128336,
0.005146471783518791,
0.000029247703423607163,
-0.02243226207792759,
-0.021269286051392555,
0.0014724544016644359,
-0.03827032819390297,
0.009849334135651588,
-0.009327792562544346,
-0.01878746971487999,
0.004546999000012875,
0.002254016697406769,
0.060235001146793365,
0.021077454090118408,
-0.010670611634850502,
0.02604108676314354,
0.03026137314736843,
0.009915275499224663,
0.014902886934578419,
-0.024062827229499817,
-0.04613540694117546,
0.07831509411334991,
0.039948850870132446,
-0.001894333167001605,
0.0037197270430624485,
0.007313564885407686,
0.03560866788029671,
-0.012253218330442905,
0.00039452785858884454,
0.017912238836288452,
-0.011473904363811016,
-0.026400770992040634,
-0.004304212983697653,
0.0359683521091938,
-0.010358885861933231,
-0.04891695827245712,
0.001949784462340176,
-0.01943489909172058,
-0.008188795298337936,
0.014327393844723701,
0.02536967769265175,
0.05169851332902908,
0.04738231003284454,
-0.047286394983530045,
0.031220529228448868,
-0.02819918841123581,
0.007079770788550377,
0.0071097444742918015,
0.019039247184991837,
0.008464552462100983,
-0.02731196954846382,
-0.046567026525735855,
-0.028750702738761902,
-0.036375992000103,
-0.02740788459777832,
-0.013212374411523342,
-0.01224722433835268,
-0.028702745214104652,
-0.00800295826047659,
-0.009939254261553288,
0.00794900581240654,
0.02306770347058773,
-0.0054851737804710865,
-0.03803053870797157,
-0.04891695827245712,
-0.01302054338157177,
-0.033426590263843536,
0.021077454090118408,
-0.030597077682614326,
0.018571659922599792,
0.045703787356615067,
-0.03551275283098221,
-0.009249861352145672,
-0.012948607094585896,
0.02377508021891117,
-0.020609864965081215,
-0.04529614374041557,
0.012816722504794598,
-0.008932140655815601,
0.044360969215631485,
-0.00007469989941455424,
0.010904405266046524,
0.012373113073408604,
0.005479178857058287,
-0.010658621788024902,
0.001164475455880165,
0.023367440328001976,
0.03232355788350105,
-0.018176008015871048,
0.02664056047797203,
0.005329310894012451,
-0.0038066506385803223,
0.008170810528099537,
-0.009669492021203041,
-0.023259535431861877,
0.01950683631002903,
-0.004954640753567219,
-0.02095755934715271,
-0.011156183667480946,
-0.006198545917868614,
-0.012373113073408604,
-0.010802495293319225,
-0.0006594198057428002,
-0.0036897535901516676,
-0.015082729049026966,
-0.036495886743068695,
0.025633445009589195,
-0.028055313974618912,
0.014723045751452446,
0.005167453084141016,
0.00452002277597785,
0.03961314633488655,
0.00006271044549066573,
-0.023547280579805374,
0.041531458497047424,
0.005236392840743065,
0.0022465232759714127,
-0.03170010820031166,
-0.032827116549015045,
-0.019291026517748833,
0.03560866788029671,
-0.03486532345414162,
0.026304855942726135,
-0.02390696480870247,
0.0028864601626992226,
0.003797658486291766,
-0.0036837586667388678,
0.014974824152886868,
0.00525137921795249,
0.04486452415585518,
0.011282073333859444,
-0.04563184827566147,
0.004864719696342945,
-0.0028819642029702663,
0.001112770871259272,
-0.007883063517510891,
0.03102869912981987,
0.010796500369906425,
-0.037095360457897186,
-0.014231477864086628,
-0.028582850471138954,
0.010592679493129253,
0.020382067188620567,
0.03155623376369476,
-0.017864281311631203,
-0.012253218330442905,
0.02022620290517807,
0.039349377155303955,
0.024182721972465515,
-0.0077571747824549675,
-0.029254259541630745,
0.03234753757715225,
0.020693792030215263,
-0.02752777934074402,
0.00046646458213217556,
0.0430181510746479,
-0.008014948107302189,
-0.03659180551767349,
-0.00041438540210947394,
-0.0021835786756128073,
0.008392615243792534,
-0.025513552129268646,
-0.025801297277212143,
0.010280953720211983,
0.006624171510338783,
0.007643274962902069,
-0.011989451013505459,
-0.018643595278263092,
-0.0288466177880764,
-0.026184961199760437,
0.006726081948727369,
-0.012564944103360176,
-0.010442811995744705,
0.017696429044008255,
0.009195908904075623,
0.008758293464779854,
0.006786029320210218,
-0.042298782616853714,
0.011090242303907871,
0.008296700194478035,
-0.03345056623220444,
0.03699944540858269,
0.0075113908387720585,
-0.022120537236332893,
-0.019698668271303177,
0.006564224138855934,
0.004238270688802004,
-0.022636083886027336,
-0.029374154284596443,
0.016293663531541824,
-0.01118615735322237,
-0.01947086863219738,
-0.03110063448548317,
-0.02738390490412712,
-0.0021476102992892265,
0.050115905702114105,
0.07673248648643494,
-0.04208297282457352,
-0.01191751379519701,
-0.040764134377241135,
0.0004896941245533526,
0.008014948107302189,
0.008278715424239635,
0.010232996195554733,
-0.004951643291860819,
-0.004930661525577307,
-0.020597876980900764,
0.10243786871433258,
0.005560107994824648,
0.025393657386302948,
-0.035728562623262405,
-0.0032611305359750986,
-0.01401566807180643,
-0.009525618515908718,
-0.007559348829090595,
-0.019698668271303177,
-0.012073377147316933,
-0.00489769084379077,
-0.0029044444672763348,
-0.029374154284596443,
-0.04174726828932762,
0.007373512256890535,
0.03884582221508026,
0.04997203126549721,
0.0044061229564249516,
-0.012103350833058357,
-0.02011829800903797,
-0.007463433314114809,
-0.007475422695279121,
-0.014543203637003899,
0.0062524983659386635,
0.031436339020729065,
0.04599153250455856,
0.00020232198585290462,
-0.016161778941750526,
-0.031364403665065765,
-0.06057070568203926,
0.01670130528509617,
0.011413956992328167,
0.03771881386637688,
-0.01547838095575571,
0.0107785165309906,
-0.02515386790037155,
0.018391817808151245,
-0.011383983306586742,
0.044313009828329086,
0.048053719103336334,
0.006630166433751583,
-0.02081368677318096,
-0.029422111809253693,
-0.009399729780852795,
-0.01052074320614338,
0.01661737821996212,
-0.010221006348729134,
0.01867956481873989,
0.0023469349835067987,
0.027192074805498123,
-0.003186196554452181,
0.01721685193479061,
-0.010388859547674656,
-0.006348414346575737,
0.020681802183389664,
0.029254259541630745,
-0.05289745703339577,
0.04428903013467789,
-0.03738310933113098,
-0.023523302748799324,
0.012540965341031551,
-0.007427464704960585,
-0.036375992000103,
-0.034337788820266724,
-0.05361682549118996,
0.02968588098883629,
0.005029574502259493,
-0.016965072602033615,
0.002069678856059909,
0.0023859008215367794,
0.05006794631481171,
-0.0072176493704319,
-0.05289745703339577,
-0.025729361921548843,
-0.025057952851057053,
0.008752299472689629,
0.021521063521504402,
-0.02596914954483509,
-0.01656942069530487,
-0.004924667067825794,
0.01266086008399725,
0.008848214522004128,
-0.036375992000103,
-0.0037287191953510046,
-0.027575736865401268,
-0.009663497097790241,
0.001756454585120082,
0.012163298204541206,
-0.021053476259112358,
-0.04618336260318756,
0.007978979498147964,
0.00556610245257616,
-0.02088562399148941,
-0.016437536105513573,
-0.007523380219936371,
-0.0037227245047688484,
-0.0043311892077326775,
0.028606830164790154,
-0.022648071870207787,
0.009088004007935524,
-0.022540166974067688,
-0.01302054338157177,
0.029973626136779785,
-0.027743589133024216,
0.0007830610265955329,
-0.009747423231601715,
-0.02394293248653412,
-0.011833587661385536,
0.01119215227663517,
0.0013158422661945224,
-0.007883063517510891,
-0.019710656255483627,
0.006492287386208773,
0.04095596447587013,
0.009207897819578648,
-0.0035908406134694815,
-0.006192551460117102,
0.04062025994062424,
-0.019231079146265984,
-0.0090520353987813,
-0.017660461366176605,
0.002460834803059697,
-0.029038449749350548,
0.0435217060148716,
0.014363362453877926,
0.0288466177880764,
0.021449128165841103,
-0.09025658667087555,
-0.017852291464805603,
-0.029853733256459236,
-0.030812889337539673,
-0.036447931081056595,
0.0031142598018050194,
-0.0361601822078228,
-0.004184318240731955,
0.02894253470003605,
0.00593777559697628,
0.0016725283348932862,
-0.033690355718135834,
-0.025705382227897644,
0.01731276698410511,
0.01150387804955244,
-0.01666533574461937,
-0.015190633945167065,
-0.02304372377693653,
0.0028999485075473785,
0.018955321982502937,
0.01264887023717165,
-0.012013429775834084,
0.0071876756846904755,
-0.0058118863962590694,
-0.01656942069530487,
0.005404245108366013,
-0.0061326040886342525,
-0.024938058108091354,
0.0016410560347139835,
-0.031340423971414566,
0.01547838095575571,
0.026976265013217926,
-0.03261130675673485,
0.013164416886866093,
-0.018979299813508987,
-0.030573099851608276,
0.03381025046110153,
0.008170810528099537,
0.0038186400197446346,
0.04618336260318756,
0.0025672412011772394,
0.024110784754157066,
-0.000557134801056236,
-0.0031652150209993124,
-0.03018943779170513,
0.0063963718712329865,
-0.019806573167443275,
-0.017037009820342064,
0.020777719095349312,
0.006804013159126043,
0.017828313633799553,
-0.03817441314458847,
-0.029206302016973495,
0.0018838424002751708,
-0.0289665125310421,
-0.005826873239129782,
-0.009345777332782745,
-0.00739749101921916,
0.00575193902477622,
-0.008392615243792534,
-0.009297818876802921,
0.03335465118288994,
0.031196551397442818,
-0.004741827957332134,
-0.028726724907755852,
-0.021053476259112358,
-0.02457837387919426,
0.027144117280840874,
-0.04244265705347061,
0.0359443724155426,
-0.03261130675673485,
0.03311486169695854,
-0.05169851332902908,
0.008860204368829727,
-0.005005595739930868,
0.017132924869656563,
-0.007919032126665115,
0.007517385762184858,
0.003051315201446414,
0.025657424703240395,
-0.007301575504243374,
-0.02237231470644474,
-0.04817361384630203,
-0.0013563066022470593,
-0.020489972084760666,
-0.008926145732402802,
0.011641756631433964,
0.020322119817137718,
-0.020657824352383614,
0.011072257533669472,
-0.024914078414440155,
-0.03807849436998367,
-0.015058750286698341,
0.023583250120282173,
-0.009309808723628521,
-0.016893135383725166,
-0.029829753562808037,
-0.0126009127125144,
0.016317643225193024,
-0.03906163200736046,
0.025825276970863342,
-0.02444648928940296,
0.02023819275200367,
0.0012161799240857363,
-0.003524898551404476,
-0.01586204394698143,
0.03476940840482712,
-0.006798018701374531,
-0.011947487480938435,
-0.03834226354956627,
0.03985293582081795,
0.01739669218659401,
0.006090641021728516,
-0.013092480599880219,
0.004861722234636545,
0.028606830164790154,
0.01803213357925415,
-0.01588602177798748,
0.029973626136779785,
0.004436096642166376,
0.05831668898463249,
0.007966989651322365,
0.0034469671081751585,
0.022767966613173485,
-0.028414998203516006,
0.002871473552659154,
0.003692750819027424,
0.002729098778218031,
0.007133723236620426,
0.008512509986758232,
0.01600591652095318,
-0.0034529617987573147,
-0.004813764709979296,
-0.0071097444742918015,
0.002817520871758461,
0.0288466177880764,
0.011485894210636616,
0.018427785485982895,
-0.03179602324962616,
0.02021421492099762,
0.009153945371508598,
-0.02156902104616165,
-0.012696828693151474,
-0.0015189135447144508,
0.01553832832723856,
0.0005211664247326553,
-0.017732398584485054,
0.02455439604818821,
-0.0008400108781643212,
0.018955321982502937,
-0.016437536105513573,
0.02312765084207058,
0.02606506645679474,
0.02731196954846382,
0.016209738329052925,
0.02817520871758461,
0.008932140655815601,
-0.003599832532927394,
-0.05356886610388756,
-0.005593078676611185,
-0.017108947038650513,
0.03042922541499138,
-0.03162817284464836,
-0.018427785485982895,
0.004966630134731531,
-0.020442012697458267,
-0.005557110533118248,
0.028654787689447403,
0.030669014900922775,
0.004963632673025131,
-0.007913037203252316,
-0.045128293335437775,
0.017816323786973953,
-0.00010097365884575993,
0.0005451453616842628,
0.0018433780642226338,
0.012019424699246883,
0.023655185475945473,
0.036543846130371094,
0.03393014520406723,
-0.001614079810678959,
-0.0016800217563286424,
0.010352890938520432,
0.005125490017235279,
0.031484298408031464,
-0.010652626864612103,
-0.04783790931105614,
-0.03520102798938751,
0.03879786282777786,
0.025009993463754654,
-0.02951802872121334,
0.014147551730275154,
0.0108804265037179,
0.027671651914715767,
0.029350174590945244,
-0.010850452817976475,
-0.017576534301042557,
0.014663098379969597,
-0.0362321212887764,
-0.05970746651291847,
-0.04239469766616821,
0.021233316510915756,
0.05414436012506485,
-0.022588124498724937,
0.009627529419958591,
0.013176406733691692,
-0.008212774060666561,
-0.03975701704621315,
-0.02584925666451454,
0.04831748828291893,
0.019374951720237732,
0.06330429762601852,
-0.03750300034880638,
-0.003324075136333704,
0.022983776405453682,
0.04179522395133972,
0.006063664797693491,
0.032827116549015045,
-0.015550317242741585,
-0.03534490242600441,
-0.030788909643888474,
-0.029973626136779785,
-0.006216530222445726,
-0.025465592741966248,
0.014399330131709576,
0.012199265882372856,
-0.004741827957332134,
0.026880348101258278,
-0.022180484607815742,
0.008662378415465355,
-0.0013068501139059663,
0.022935818880796432,
-0.004115378949791193,
0.004720846191048622,
0.01014907006174326,
-0.010598674416542053,
0.002448845421895385,
-0.006084646098315716,
-0.011156183667480946,
-0.00139377370942384,
0.030860846862196922,
-0.022779956459999084,
-0.0005327812395989895,
-0.024962035939097404,
-0.02462633140385151,
-0.009831349365413189,
0.02457837387919426,
-0.016389578580856323,
-0.02666453830897808,
0.019291026517748833,
-0.020597876980900764,
-0.017684439197182655,
0.03886979818344116,
0.04131564870476723,
0.014627129770815372,
-0.0004252508224453777,
-0.010274959728121758,
0.004391136579215527,
0.0006212033913470805,
-0.003228159621357918,
-0.020382067188620567,
-0.006057669874280691,
0.008878188207745552,
-0.01474702451378107,
0.01959076337516308,
-0.005685997195541859,
-0.0032701226882636547,
-0.03886979818344116,
0.027216052636504173,
0.03743106499314308,
0.03673567622900009,
-0.0035938378423452377,
-0.02099352888762951,
0.006492287386208773,
0.000050861497584264725,
-0.034889303147792816,
0.03968508169054985,
0.014543203637003899,
0.02819918841123581,
-0.02815123088657856,
-0.0023079693783074617,
-0.0076552643440663815,
-0.018583647906780243,
0.010928384028375149,
0.01745663955807686,
-0.014723045751452446,
-0.030836867168545723,
-0.02021421492099762,
0.008758293464779854,
0.013967710547149181,
-0.026328833773732185,
0.015310528688132763,
-0.01406362559646368,
-0.012540965341031551,
-0.027120137587189674,
-0.012469029054045677,
-0.018415795639157295,
0.004771801643073559,
0.008128847926855087,
0.0026002121157944202,
0.02311566099524498,
0.015058750286698341,
-0.02812725119292736,
-0.027072180062532425,
0.006983855273574591,
-0.009321797639131546,
-0.02013028785586357,
-0.06114619970321655,
0.02388298511505127,
-0.00941171869635582,
-0.03150827810168266,
0.009813365526497364,
0.00942370854318142,
-0.02743186429142952,
0.031340423971414566,
0.02958996407687664,
-0.015694191679358482,
0.002866977360099554,
-0.029733838513493538,
0.013679963536560535,
-0.011168173514306545,
0.023295503109693527,
0.01547838095575571,
0.012756776064634323,
-0.008284710347652435,
-0.0090640252456069,
-0.012445050291717052,
0.010688595473766327,
-0.026496686041355133,
-0.013895773328840733,
0.029781796038150787,
-0.010185038670897484,
-0.016353610903024673,
-0.0045529939234256744,
-0.02457837387919426,
0.006156582850962877,
0.01008312776684761,
0.013524100184440613,
0.021868757903575897,
-0.011527856811881065,
-0.013572058640420437,
-0.014711055904626846,
0.004283231217414141,
0.012804733589291573,
0.008380626328289509,
0.009807370603084564,
-0.005401247646659613,
-0.014363362453877926,
0.004394133575260639,
-0.006881944835186005,
0.06378387659788132,
-0.008098874241113663,
-0.026376791298389435,
0.05635041743516922,
0.01303253322839737,
0.00942370854318142,
0.00471185427159071,
0.010191033594310284,
-0.003710735123604536,
0.011024300009012222,
-0.00790104828774929,
0.011168173514306545,
-0.005152466241270304,
-0.0029494049958884716,
0.03747902438044548,
0.0027950406074523926,
-0.042922232300043106,
-0.001524908235296607,
-0.005739949643611908,
0.019950445741415024,
0.0022585128899663687,
0.037814728915691376,
-0.018235955387353897,
-0.013991689309477806,
0.014351372607052326,
0.01863160729408264,
0.05260971188545227,
0.04026057571172714,
0.010310927405953407,
0.03390616551041603,
0.009651508182287216,
-0.008770283311605453,
-0.0033510515931993723,
-0.01721685193479061,
-0.014327393844723701,
-0.017504598945379257,
-0.004400128498673439,
-0.03659180551767349,
0.00024091302475426346,
-0.014986813068389893,
-0.00942970346659422,
0.020789707079529762,
0.043737515807151794,
0.009076014161109924,
-0.007835105992853642,
-0.017108947038650513,
0.018211975693702698,
0.006762050092220306,
0.006510271690785885,
-0.016293663531541824,
0.005401247646659613,
0.001201193081215024,
0.004079410806298256,
-0.020777719095349312,
0.034265849739313126,
0.017624491825699806,
-0.010244986042380333,
0.008752299472689629,
-0.0073675173334777355,
-0.011731677688658237,
-0.02379905991256237,
-0.013907763175666332,
-0.04541603848338127,
0.006456319242715836,
-0.007823117077350616,
-0.0047328355722129345,
-0.013080490753054619,
-0.008176805451512337,
-0.0022974784951657057,
-0.003102270420640707,
0.015382464975118637,
0.006009712349623442,
0.007565343286842108,
-0.006977860350161791,
-0.016977062448859215,
-0.004786788020282984,
-0.015718169510364532,
0.015370476059615612,
-0.016077853739261627,
0.061050284653902054,
0.009849334135651588,
-0.0019347976194694638,
0.027072180062532425,
-0.016977062448859215,
-0.026304855942726135,
0.0015481378650292754,
0.013967710547149181,
0.0361122265458107,
-0.022767966613173485,
-0.009261850267648697,
0.0017984176520258188,
0.015286549925804138,
0.042370717972517014,
0.012804733589291573,
0.004594956990331411,
-0.009303813800215721,
-0.006216530222445726,
-0.019734635949134827,
0.024146754294633865,
0.018343860283493996,
0.01664135791361332,
0.04033251106739044,
-0.036184161901474,
-0.016821200028061867,
-0.009993207640945911,
-0.000831018784083426,
-0.02752777934074402,
-0.011354009620845318,
0.010011191479861736,
0.025465592741966248,
0.00031697109807282686,
0.004801774863153696,
0.004247263073921204,
0.02817520871758461,
0.0002677019510883838,
-0.0029898693319410086,
-0.007133723236620426,
0.009171930141746998,
-0.0063963718712329865,
0.003476940793916583,
0.009339782409369946,
0.0016875151777639985,
0.004478059709072113,
0.009525618515908718,
0.02313964068889618,
-0.0181160606443882,
0.006977860350161791,
0.019734635949134827,
0.022168494760990143,
-0.02322356589138508,
-0.006402366794645786,
0.022012632340192795,
-0.017156904563307762,
-0.009333787485957146,
0.024026859551668167,
0.02733594737946987,
0.008794262073934078,
-0.0434257909655571,
0.03409799933433533,
-0.008344657719135284,
0.003285109531134367,
-0.00014274939894676208,
-0.016713295131921768,
0.0015496364794671535,
0.008536488749086857,
0.018283912912011147,
0.0005451453616842628,
-0.007181681226938963,
0.0020936578512191772,
-0.025825276970863342,
-0.02022620290517807,
-0.00028774680686183274,
-0.028438977897167206,
-0.041507478803396225,
-0.004013468511402607,
-0.0434018112719059,
-0.011731677688658237,
-0.05692591145634651,
0.006270482670515776,
0.012576933950185776,
-0.05270562693476677,
-0.0216649379581213,
-0.008890178054571152,
0.008290705271065235,
0.0251778457313776,
-0.021868757903575897,
0.0015069240471348166,
0.01870354264974594,
0.025777319446206093,
0.027000242844223976,
0.02297178842127323,
0.017840303480625153,
0.020549919456243515,
-0.01192950364202261,
-0.032107748091220856,
0.011162178590893745,
0.0006324435235001147,
0.034217894077301025,
-0.014998802915215492,
0.028055313974618912,
0.020046360790729523,
-0.026208939030766487,
0.030597077682614326,
-0.023511312901973724,
-0.005392255261540413,
0.03371433541178703,
0.02901447005569935,
-0.005176445469260216,
-0.004460075870156288,
-0.0053862608037889,
-0.010340901091694832,
-0.006762050092220306,
0.01156982034444809,
-0.004582967609167099,
0.009987212717533112,
0.01120414212346077,
0.030812889337539673,
-0.015502359718084335,
-0.013799858279526234,
0.010712574236094952,
0.046614985913038254,
0.007319559808820486,
0.026592601090669632,
-0.008668373338878155,
0.0009554093703627586,
-0.0253456998616457,
-0.0030273362062871456,
0.0017249822849407792,
-0.02963792160153389,
-0.024842141196131706,
0.0001295422698603943,
-0.004172328859567642,
0.012361124157905579,
0.040116701275110245,
-0.015622254461050034,
-0.02954200655221939,
-0.0034020065795630217,
-0.013116459362208843,
-0.027599716559052467,
0.01957877352833748,
-0.006702103186398745,
-0.011312047019600868,
0.009016066789627075,
-0.02172488532960415,
-0.028295103460550308,
0.019243068993091583,
-0.01660539023578167,
0.001949784462340176,
-0.001525657600723207,
-0.007931021973490715,
-0.002313964068889618,
-0.02594517171382904,
-0.02391895465552807,
-0.012271203100681305,
-0.014087604358792305,
-0.007715211715549231,
-0.055199433118104935,
-0.011024300009012222,
0.029350174590945244,
-0.03237151727080345,
-0.03107665665447712,
0.01673727296292782,
-0.024842141196131706,
-0.00977140199393034,
0.0014027657452970743,
0.007607306353747845,
-0.008854209445416927,
0.0042892261408269405,
-0.04853329807519913,
0.002642175182700157,
-0.024122774600982666,
0.015022781677544117,
-0.00868036225438118,
-0.029302217066287994,
0.01191751379519701,
-0.00525737414136529,
-0.007115738932043314,
-0.04486452415585518,
-0.01008312776684761,
0.0023244547192007303,
-0.026184961199760437,
-0.018907364457845688,
0.008188795298337936,
-0.002179082715883851,
-0.020382067188620567,
-0.0006687865243293345,
-0.02467428892850876,
-0.005715970881283283,
0.031532254070043564,
-0.007325554266571999,
0.010892416350543499,
0.050931185483932495,
-0.021053476259112358,
-0.01407561544328928,
-0.011054273694753647,
0.004508033394813538,
-0.02515386790037155,
-0.000881224637851119,
0.02450643666088581,
0.015250581316649914,
0.008650388568639755,
0.01648549549281597,
0.0004822007322218269,
-0.0432819165289402,
0.0067200870253145695,
-0.02172488532960415,
-0.025657424703240395,
0.010322917252779007,
-0.029206302016973495,
0.0074334596283733845,
-0.014039646834135056,
0.017720408737659454,
0.002080169739201665,
0.006402366794645786,
-0.0034020065795630217,
0.03896571323275566,
-0.03316282108426094,
-0.021101433783769608,
0.009555592201650143,
-0.00470585934817791,
-0.031412359327077866,
0.02150907553732395,
0.024338584393262863,
-0.010916395112872124,
0.015358486212790012,
0.0029763812199234962,
-0.007823117077350616,
-0.014171530492603779,
-0.012816722504794598,
-0.01008312776684761,
0.01593397930264473,
0.013260332867503166,
-0.011288068257272243,
0.04244265705347061,
-0.00575493648648262,
0.017168894410133362,
0.02246823161840439,
-0.005008593201637268,
-0.005536128766834736,
0.028510913252830505,
-0.011294062249362469,
0.003899568924680352,
-0.039253462105989456,
-0.0090580303221941,
0.11049477756023407,
0.02668851800262928,
-0.005907801911234856,
0.03021341562271118,
-0.017576534301042557,
0.0011202642926946282,
0.030453205108642578,
0.012199265882372856,
0.008854209445416927,
-0.024194711819291115,
0.018092080950737,
0.03405003994703293,
0.019255058839917183,
0.015550317242741585,
0.018391817808151245,
-0.011449925601482391,
-0.03112461417913437,
0.04632723703980446,
-0.0026991250924766064,
0.006947886664420366,
0.010286948643624783,
0.0251778457313776,
-0.003381025046110153,
0.005641036666929722,
-0.003893574234098196,
0.003506914246827364,
-0.01867956481873989,
-0.017072977498173714,
-0.029398133978247643,
-0.007535369601100683,
0.030069543048739433,
0.014926866628229618,
-0.0011210136581212282,
0.01155783049762249,
0.007379507180303335,
0.0036298062186688185,
-0.00020700535969808698,
-0.03229958191514015,
-0.0018298899522051215,
0.01888338476419449,
0.0005294092115946114,
0.004639917518943548,
0.0033030936028808355,
0.02447046898305416,
0.0029838746413588524,
-0.014699066989123821,
-0.007361522875726223,
-0.0144472885876894,
0.01411158312112093,
-0.01593397930264473,
-0.015262571163475513,
-0.021425148472189903,
0.01009511761367321,
-0.023966912180185318,
-0.027048200368881226,
-0.013883784413337708,
0.0015069240471348166,
-0.004927664063870907,
-0.01449524611234665,
-0.01577811688184738,
-0.024134764447808266,
0.011911519803106785,
0.010568700730800629,
-0.003069299506023526,
0.009016066789627075
] | 2025-01-16 | 35 | 39815015 | [
"autologous CAR T cells",
"T cell proliferation",
"T cell activation",
"cell polarization",
"humoral immune response",
"allogeneic hematopoietic stem cell transplantation",
"cell chemotaxis",
"transcriptomic signaling analysis",
"response",
"patients",
"Allogeneic chimeric antigen receptor",
"ALLO_GD2-CAR T cells",
"decreased oxygen levels",
"CAR) T cells",
"ALLO_GD2-CART01",
"autologous GD2-CART01",
"analyses",
"drug products",
"further investigation",
"genes",
"children",
"r/r HR-NB",
"patient-matched, peripheral blood ALLO_GD2-CART01",
"addition",
"HR-NB refractory",
"grade",
"profound lymphopenia",
"Allogeneic",
"host",
"two complete responses"
] | [] | 0 | 10.1038/s41591-024-03449-x
10.1016/S1470-2045(18)30578-3
10.1016/j.pcl.2014.09.015
10.1002/cncr.30934
10.1056/NEJMoa2210859
10.1136/jitc-2020-002328
10.1182/blood-2014-05-552729
10.1016/j.annonc.2021.12.003
10.1016/j.bbmt.2015.09.001
10.3389/fimmu.2018.00184
10.4049/jimmunol.2300083
10.1128/MCB.01288-12
10.1016/j.celrep.2017.08.078
10.1083/jcb.201811139
10.1038/cdd.2012.30
10.1016/j.neo.2019.08.003
10.1016/j.cmet.2014.04.015
10.3389/fimmu.2024.1404846
10.1007/s00262-013-1479-6
10.1007/s00262-009-0715-6
10.1038/sj.bmt.1704070
10.1002/pbc.25169
10.1016/j.jtct.2024.03.002
10.1038/bmt.2012.284
10.1200/JCO.22.01630
10.1182/blood-2013-06-506741
10.1182/blood-2013-08-519413
10.1200/JCO.2015.64.5929
10.1111/bjh.14923
10.1172/JCI86721
10.3324/haematol.2023.284604
10.1182/blood.2023020814
10.1080/2162402X.2018.1433518
10.1200/JCO.2016.72.0177
10.1038/sj.cgt.7700240 | [
"Quintarelli",
"Del Bufalo",
"De Ioris",
"Guercio",
"Algeri",
"Pagliara",
"Silvestris",
"Di Nardo",
"Sinibaldi",
"Di Cecca",
"Iaffaldano",
"Manni",
"Fustaino",
"Garganese",
"Colafati",
"Bertaina",
"Becilli",
"Mastronuzzi",
"Fabozzi",
"Gunetti",
"Iacovelli",
"Bugianesi",
"Macchia",
"Li Pira",
"Cefalo",
"Leone",
"Del Baldo",
"De Angelis",
"Locatelli"
] | [
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.\nDepartment of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.\nDepartment of Health Sciences, Magna Graecia University, Catanzaro, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Pediatric Intensive Care Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Nuclear Medicine Unit/Imaging Department, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.",
"Imaging Department, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Transfusion Unit, Department of Laboratories, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy.",
"Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children's Hospital, Rome, Italy. [email protected].\nCatholic University of the Sacred Heart, Department of Life Sciences and Public Health, Rome, Italy. [email protected]."
] | [
"39815015",
"30442501",
"25435121",
"28885700",
"37018492",
"34006631",
"24876563",
"34923107",
"26386318",
"29467767",
"37449888",
"23275443",
"28930685",
"30952800",
"22421968",
"31521051",
"24856931",
"38774881",
"24081484",
"19437016",
"12815485",
"25156335",
"23419433",
"36854071",
"24030379",
"24055823",
"26811520",
"29076142",
"27482888",
"38832424",
"37172203",
"37440268",
"29872565",
"28471719",
"11129285"
] | [] | 9.686148 | 6.968077 |
39814734 | 26 | Chimeric antigen receptor macrophages (CAR-M) sensitize HER2+ solid tumors to PD1 blockade in pre-clinical models. | We previously developed human CAR macrophages (CAR-M) and demonstrated redirection of macrophage anti-tumor function leading to tumor control in immunodeficient xenograft models. Here, we develop clinically relevant fully immunocompetent syngeneic models to evaluate the potential for CAR-M to remodel the tumor microenvironment (TME), induce T cell anti-tumor immunity, and sensitize solid tumors to PD1/PDL1 checkpoint inhibition. In vivo, anti-HER2 CAR-M significantly reduce tumor burden, prolong survival, remodel the TME, increase intratumoral T cell and natural killer (NK) cell infiltration, and induce antigen spreading. CAR-M therapy protects against antigen-negative relapses in a T cell dependent fashion, confirming long-term anti-tumor immunity. In HER2+ solid tumors with limited sensitivity to anti-PD1 (aPD1) monotherapy, the combination of CAR-M and aPD1 significantly improves tumor growth control, survival, and remodeling of the TME in pre-clinical models. These results demonstrate synergy between CAR-M and T cell checkpoint blockade and provide a strategy to potentially enhance response to aPD1 therapy for patients with non-responsive tumors. | [
0.04202692210674286,
0.003244013525545597,
0.004124618135392666,
0.0646381825208664,
-0.07049677520990372,
0.003737273160368204,
0.016934234648942947,
0.03822610154747963,
0.023894337937235832,
-0.011668764986097813,
-0.00522613013163209,
-0.014791733585298061,
-0.033045362681150436,
-0.0018489666981622577,
0.015336437150835991,
-0.032052792608737946,
0.061878349632024765,
-0.006451713386923075,
0.048781249672174454,
0.04166378453373909,
0.0328516885638237,
0.006814849562942982,
-0.021727629005908966,
-0.0004966639098711312,
-0.03185911849141121,
-0.028711941093206406,
-0.03299694508314133,
0.016922131180763245,
0.020105620846152306,
-0.01715211570262909,
0.010373580269515514,
-0.009647308848798275,
-0.0615394227206707,
-0.00316230789758265,
-0.004030807875096798,
0.02429378777742386,
0.02868773229420185,
-0.020940834656357765,
-0.04149432107806206,
-0.008939194492995739,
0.0024254447780549526,
0.03943655267357826,
0.041058558970689774,
0.1084565743803978,
-0.05432512238621712,
-0.017975224182009697,
-0.010591462254524231,
-0.040913306176662445,
0.018326256424188614,
0.018386779353022575,
-0.03943655267357826,
0.010125437751412392,
-0.008824201300740242,
0.0495559386909008,
-0.03786296397447586,
0.041058558970689774,
-0.015396960079669952,
-0.007819524966180325,
-0.031011801213026047,
0.014452806673943996,
0.02321648597717285,
-0.0239911749958992,
0.036846183240413666,
-0.007190089672803879,
-0.08371491730213165,
-0.032246463000774384,
-0.05829540640115738,
-0.02284124493598938,
0.029268749058246613,
0.022938081994652748,
0.03268222510814667,
-0.024366416037082672,
-0.006379086524248123,
0.004472623113542795,
0.04374576359987259,
-0.015990082174539566,
-0.0028127897530794144,
0.04662664234638214,
-0.015372751280665398,
0.017866283655166626,
0.04115539789199829,
-0.012322410009801388,
0.009719936177134514,
-0.03331166133284569,
0.005625579506158829,
-0.008533691987395287,
0.01527591422200203,
-0.05064534768462181,
-0.05539032071828842,
-0.018072061240673065,
-0.0003986929077655077,
0.017563670873641968,
-0.016752667725086212,
0.02670259028673172,
-0.02075926586985588,
0.005534795578569174,
-0.055826082825660706,
-0.04575511813163757,
0.028034087270498276,
0.056407101452350616,
0.060619477182626724,
-0.016873711720108986,
0.0015365185681730509,
-0.02107398398220539,
0.01431965734809637,
-0.006018976680934429,
-0.04413311183452606,
0.0034558428451418877,
0.04546460881829262,
0.012122685089707375,
0.059118516743183136,
-0.05069376528263092,
0.014162298291921616,
0.02325279824435711,
-0.00972598884254694,
-0.019113050773739815,
-0.0310360100120306,
-0.0008995177340693772,
0.00972598884254694,
-0.021509746089577675,
-0.0448593832552433,
0.050403255969285965,
0.012661336921155453,
-0.04958014935255051,
0.006433556787669659,
-0.028276177123188972,
0.08957350999116898,
-0.031157055869698524,
-0.03737878426909447,
-0.03699143975973129,
0.0323432981967926,
0.007601643912494183,
0.02321648597717285,
-0.002538924803957343,
-0.0349578782916069,
0.002225720090791583,
0.00020161604334134609,
-0.004375786986202002,
-0.014961197040975094,
0.0029716617427766323,
0.02054138481616974,
-0.012661336921155453,
-0.00362530630081892,
0.013278667815029621,
-0.06865688413381577,
-0.04149432107806206,
0.008049511350691319,
0.02038402482867241,
0.024136429652571678,
0.029946602880954742,
-0.024862701073288918,
0.03839556500315666,
0.06875371932983398,
0.031011801213026047,
0.0034013723488897085,
-0.03311799094080925,
0.0016552942106500268,
0.04364892840385437,
-0.04285002872347832,
-0.06609072536230087,
-0.025129001587629318,
0.029535049572587013,
-0.06599389016628265,
-0.013266563415527344,
0.010161751881241798,
0.005755702964961529,
-0.00840054266154766,
0.0258068535476923,
-0.07722689211368561,
-0.016207963228225708,
-0.023482784628868103,
0.0028294334188103676,
-0.04720766097307205,
-0.023204380646348,
-0.06090998649597168,
0.005516638979315758,
-0.00904813501983881,
0.020105620846152306,
-0.024959538131952286,
0.010881970636546612,
-0.009435479529201984,
0.051855798810720444,
0.026266826316714287,
0.0203356072306633,
-0.028227759525179863,
0.01371443085372448,
0.005383488722145557,
0.04924122244119644,
-0.033723216503858566,
-0.014125984162092209,
0.013859684579074383,
-0.008176608942449093,
0.07325660437345505,
0.03299694508314133,
0.006911685690283775,
-0.0034528167452663183,
0.027501488104462624,
-0.0018489666981622577,
-0.0260731540620327,
-0.01636532135307789,
0.030067648738622665,
-0.008182660676538944,
-0.0247779693454504,
-0.00980466790497303,
-0.021352387964725494,
-0.036943018436431885,
-0.03943655267357826,
0.026363663375377655,
-0.006073446944355965,
0.024342207238078117,
0.05277574434876442,
-0.002298347419127822,
0.0062761977314949036,
0.031157055869698524,
-0.00436670845374465,
-0.04139748588204384,
-0.008485274389386177,
0.05011274665594101,
0.024184847250580788,
0.03641042113304138,
-0.029801348224282265,
-0.004248689394444227,
0.0297287218272686,
0.01008912455290556,
-0.02900245040655136,
0.010621723718941212,
0.02049296721816063,
-0.032875899225473404,
-0.008533691987395287,
-0.023228589445352554,
0.0060341074131429195,
0.017503147944808006,
-0.014198611490428448,
-0.009980184026062489,
-0.01841098815202713,
0.003776612924411893,
0.007674270775169134,
-0.010500677861273289,
0.03708827495574951,
-0.022332854568958282,
0.010682246647775173,
0.04401206597685814,
0.007910309359431267,
0.0008442908292636275,
-0.016813190653920174,
0.015820618718862534,
-0.0002158010465791449,
-0.07422496378421783,
0.006306459195911884,
-0.03270643576979637,
-0.004197244998067617,
-0.0034316338133066893,
-0.005307835526764393,
0.018653078004717827,
0.016607413068413734,
0.05233997851610184,
0.021037669852375984,
0.00818871334195137,
-0.02534688264131546,
-0.03430423140525818,
-0.012552395462989807,
0.029075076803565025,
-0.019633544608950615,
-0.04517409950494766,
-0.024862701073288918,
-0.002349791582673788,
-0.0273804422467947,
0.018374674022197723,
0.026533126831054688,
0.017721028998494148,
0.04803076758980751,
0.01841098815202713,
0.039460763335227966,
0.005244286730885506,
-0.050258003175258636,
0.00876367837190628,
0.0026599701959639788,
0.05689128115773201,
0.0017309475224465132,
0.01574799045920372,
-0.012007691897451878,
-0.01601429097354412,
0.02462061122059822,
0.002641813363879919,
0.012528186663985252,
0.002531359437853098,
0.020952938124537468,
0.022562840953469276,
-0.026533126831054688,
-0.061926767230033875,
0.00933259166777134,
-0.021655000746250153,
-0.009302330203354359,
-0.02779199741780758,
-0.008497378788888454,
0.007982936687767506,
-0.023071231320500374,
-0.026460498571395874,
-0.02252652682363987,
0.047788675874471664,
0.007765054702758789,
0.01762419380247593,
-0.04323737323284149,
-0.061878349632024765,
0.013520757667720318,
0.003501234808936715,
0.0038189785555005074,
-0.06076473370194435,
0.02508058212697506,
0.025153210386633873,
0.027985669672489166,
-0.016970548778772354,
0.008358176797628403,
0.02675100788474083,
0.0022015110589563847,
0.01509434636682272,
0.030963383615016937,
-0.04655401408672333,
0.020468756556510925,
-0.0542282871901989,
-0.06550970673561096,
-0.00025854515843093395,
-0.06265303492546082,
-0.03343270719051361,
0.006699856370687485,
-0.023204380646348,
-0.006136995740234852,
-0.02665417082607746,
0.0033620328176766634,
-0.053163088858127594,
0.017926806584000587,
-0.0017460782546550035,
0.0526789054274559,
-0.032198045402765274,
0.0038129263557493687,
-0.04885387793183327,
-0.03953338786959648,
-0.02701730653643608,
0.002585829934105277,
0.006772483699023724,
0.00654249731451273,
-0.016619516536593437,
-0.025322673842310905,
0.044980425387620926,
-0.002572212368249893,
-0.0074684941209852695,
0.025371091440320015,
0.05679444596171379,
0.012963949702680111,
0.018471509218215942,
0.0011287472443655133,
0.011644556187093258,
0.02878456749022007,
0.026920471340417862,
-0.0226838868111372,
0.03737878426909447,
-0.02868773229420185,
-0.014247030019760132,
0.011335890740156174,
-0.004554328974336386,
-0.011184584349393845,
0.020892415195703506,
-0.03800822049379349,
0.03217383474111557,
0.04631192609667778,
0.04495621845126152,
-0.050354838371276855,
0.03411056101322174,
-0.021364493295550346,
-0.022877559065818787,
-0.01491277851164341,
0.018072061240673065,
0.03435265272855759,
0.022018136456608772,
-0.006833006162196398,
0.0526789054274559,
0.02325279824435711,
0.01683739945292473,
0.030019229277968407,
-0.007631904911249876,
0.049870654940605164,
-0.01491277851164341,
-0.013944416306912899,
-0.018435196951031685,
-0.0474497526884079,
0.026000527665019035,
0.021400805562734604,
-0.01632900908589363,
-0.051758963614702225,
0.01290342677384615,
-0.00283548585139215,
-0.009350747801363468,
0.02195761352777481,
0.02003299444913864,
-0.04703819751739502,
0.059990040957927704,
-0.008297653868794441,
0.03875869885087013,
0.0385892353951931,
0.007414023391902447,
-0.013460235670208931,
-0.03198016434907913,
-0.039024997502565384,
-0.03270643576979637,
0.015179078094661236,
-0.02476586401462555,
0.05950586125254631,
-0.0039975205436348915,
0.007069044280797243,
0.020190352573990822,
-0.00941127073019743,
-0.028445640578866005,
0.029970811679959297,
0.014234925620257854,
0.0072203511372208595,
-0.02810671553015709,
-0.008884723298251629,
0.042583730071783066,
0.028857195749878883,
-0.006475922651588917,
0.036943018436431885,
-0.051129527390003204,
0.028954030945897102,
-0.0323432981967926,
0.015929559245705605,
-0.007190089672803879,
0.038298726081848145,
0.010918284766376019,
-0.006415400188416243,
-0.05364726856350899,
-0.018084164708852768,
0.0594574436545372,
0.011118009686470032,
-0.009586786851286888,
0.005286652594804764,
0.07291767746210098,
-0.05679444596171379,
-0.0054046716541051865,
-0.04420573636889458,
0.029389794915914536,
-0.020420338958501816,
-0.0033317713532596827,
0.0034558428451418877,
-0.032367508858442307,
0.04130065068602562,
0.011584033258259296,
0.001258870935998857,
0.015166973695158958,
-0.012951845303177834,
-0.018241524696350098,
-0.0069722081534564495,
-0.021860778331756592,
-0.012564500793814659,
0.010851709172129631,
0.022490212693810463,
-0.010464364662766457,
0.018217315897345543,
-0.047788675874471664,
0.011275367811322212,
-0.013157621957361698,
0.05824698880314827,
-0.01976669393479824,
-0.0007943596574477851,
-0.057133372873067856,
-0.029801348224282265,
0.032367508858442307,
0.00380687415599823,
-0.007637957111001015,
-0.00393699761480093,
-0.014936988241970539,
0.03168965503573418,
0.00988334696739912,
-0.034861043095588684,
0.026678379625082016,
-0.025225836783647537,
-0.0014532998902723193,
0.00019877904560416937,
0.0034195291809737682,
0.04297107458114624,
0.022490212693810463,
0.021921301260590553,
-0.03200437128543854,
-0.030309738591313362,
0.007886100560426712,
0.0312780998647213,
0.05355043336749077,
-0.04512568190693855,
0.02023877203464508,
-0.0161595456302166,
0.048684414476156235,
0.013387608341872692,
0.008237131871283054,
0.02951084077358246,
-0.011795862577855587,
-0.004778262693434954,
-0.03328745439648628,
0.024281684309244156,
-0.005643736105412245,
-0.010101228952407837,
-0.0011552259093150496,
-0.004372760653495789,
0.036434631794691086,
0.026872051879763603,
0.01669214479625225,
0.07010942697525024,
0.03306956961750984,
-0.007274821400642395,
0.061829932034015656,
0.021715523675084114,
0.036628302186727524,
-0.037524037063121796,
-0.0014041252434253693,
0.013339189812541008,
0.004421179182827473,
-0.010034654289484024,
-0.00959283858537674,
-0.035538893193006516,
-0.0063669816590845585,
-0.00494167348369956,
0.005099032539874315,
-0.007728741504251957,
-0.02065032534301281,
-0.012939740903675556,
0.02728360705077648,
0.033142197877168655,
-0.04137327894568443,
-0.021981824189424515,
-0.02410011552274227,
-0.018967796117067337,
-0.033239033073186874,
0.002239337656646967,
-0.0206019077450037,
0.04047754406929016,
-0.004472623113542795,
0.010083071887493134,
-0.027767788618803024,
-0.049095965921878815,
0.015396960079669952,
0.009405218064785004,
-0.02154606021940708,
0.044714126735925674,
-0.0018353491323068738,
0.027138352394104004,
-0.02977713942527771,
0.006173309404402971,
0.05083901807665825,
0.005649788770824671,
-0.0166800394654274,
0.031374938786029816,
-0.027888832613825798,
0.028590895235538483,
-0.01364180352538824,
0.006251988932490349,
0.0028248943854123354,
0.03135072812438011,
-0.02180025540292263,
-0.006711960770189762,
-0.024644820019602776,
-0.01590535044670105,
-0.00876367837190628,
-0.03253697231411934,
0.014404389075934887,
0.019996680319309235,
-0.006130943540483713,
-0.013278667815029621,
0.021509746089577675,
0.0018883064622059464,
-0.011372203938663006,
-0.032101210206747055,
0.020262980833649635,
0.007383762393146753,
0.0166800394654274,
-0.011577981524169445,
-0.02696888893842697,
0.04413311183452606,
0.014222820289433002,
-0.0037191163282841444,
0.023494889959692955,
0.0026115518994629383,
0.005250338930636644,
-0.03844398260116577,
0.005223103798925877,
0.015820618718862534,
0.06270145624876022,
-0.027888832613825798,
0.02846985124051571,
-0.04355209320783615,
-0.02534688264131546,
0.0043515777215361595,
-0.005828330293297768,
-0.0018852802459150553,
-0.0038129263557493687,
0.03306956961750984,
0.0036676721647381783,
-0.03207699954509735,
0.016958443447947502,
0.021655000746250153,
0.005610448773950338,
-0.020952938124537468,
-0.004384865518659353,
0.010058863088488579,
0.006022003013640642,
0.0012664363021031022,
-0.029292957857251167,
-0.01332708541303873,
0.01935514062643051,
-0.007395866792649031,
-0.009496002458035946,
-0.013799162581562996,
-0.01267344132065773,
0.02675100788474083,
0.023664353415369987,
-0.010948546230793,
-0.005964506417512894,
0.0026539177633821964,
-0.002181841293349862,
-0.025371091440320015,
0.00479641929268837,
0.021412910893559456,
-0.028857195749878883,
-0.01636532135307789,
-0.0297287218272686,
-0.004182114731520414,
-0.002896008314564824,
-0.003561757504940033,
-0.053744103759527206,
-0.01782996952533722,
-0.0044665709137916565,
-0.007522964384406805,
0.0010833552805706859,
0.0011597650591284037,
-0.026218408718705177,
0.013605489395558834,
0.034497905522584915,
0.02206655591726303,
-0.02263546735048294,
0.011087748222053051,
0.013133413158357143,
-0.02362803928554058,
-0.00425171572715044,
-0.026412080973386765,
0.015505900606513023,
-0.018229419365525246,
-0.04270477592945099,
0.007093253545463085,
0.012183208018541336,
-0.00779531616717577,
0.020057203248143196,
-0.00039907117024995387,
-0.023543307557702065,
0.000646835716906935,
-0.04916859418153763,
0.00024246882821898907,
0.002134936163201928,
0.019221991300582886,
-0.006421452388167381,
0.007256664801388979,
0.00818871334195137,
0.01249187346547842,
0.05829540640115738,
-0.02936558611690998,
0.039194460958242416,
-0.02065032534301281,
-0.022381272166967392,
-0.022332854568958282,
0.0333600789308548,
-0.018992004916071892,
0.03369900584220886,
0.035756777971982956,
0.00014771307178307325,
0.07001259177923203,
-0.016764771193265915,
0.028251968324184418,
-0.011323786340653896,
-0.016086917370557785,
0.009786510840058327,
0.0058979312889277935,
-0.01908884197473526,
0.00040058422018773854,
0.013883894309401512,
0.026460498571395874,
0.023603830486536026,
-0.025492137297987938,
-0.059263769537210464,
0.024790074676275253,
0.006627229042351246,
-0.0025812906678766012,
-0.006264093331992626,
-0.004869046621024609,
-0.011789810843765736,
-0.005017327144742012,
-0.027138352394104004,
-0.01632900908589363,
-0.02863931469619274,
0.014767524786293507,
0.014513329602777958,
0.014646478928625584,
-0.005961480084806681,
0.01893148198723793,
-0.04314053803682327,
0.022042345255613327,
0.025104790925979614,
0.008479221723973751,
-0.005719389766454697,
0.03265801817178726,
-0.008037406951189041,
-0.014041252434253693,
-0.017854178324341774,
0.008116086013615131,
0.005689128302037716,
0.004182114731520414,
0.004139748867601156,
-0.010331215336918831,
-0.009750197641551495,
0.006306459195911884,
0.010216222144663334,
-0.014900674112141132,
0.049870654940605164,
-0.0005012031178921461,
0.02164289727807045,
-0.008164504542946815,
0.014936988241970539,
-0.005692154634743929,
-0.013750744052231312,
0.02752569690346718,
0.039291299879550934,
-0.004263820126652718,
0.037524037063121796,
-0.016498472541570663,
-0.020069308578968048,
-0.004841811489313841,
-0.006657490506768227,
-0.029922394081950188,
0.0034861040767282248,
-0.017648402601480484,
0.046384550631046295,
-0.02982555702328682,
-0.017926806584000587,
-0.007208246737718582,
0.0038401614874601364,
0.009314434602856636,
-0.01836256869137287,
-0.032827481627464294,
-0.0008389950962737203,
-0.0032379613257944584,
0.027089934796094894,
0.04958014935255051,
-0.0156511552631855,
0.012013744562864304,
0.0224175862967968,
-0.0020653351675719023,
0.008824201300740242,
-0.0020032995380461216,
0.022284436970949173,
-0.012516082264482975,
-0.0281551331281662,
0.011929012835025787,
0.03018869273364544,
-0.024015383794903755,
-0.005870696157217026,
-0.0001999138476094231,
0.0032984840217977762,
-0.006603020243346691,
-0.012158998288214207,
-0.010476469062268734,
0.02362803928554058,
0.03822610154747963,
0.011202740482985973,
-0.018229419365525246,
0.02571001835167408,
-0.0058979312889277935,
-0.013920207507908344,
-0.00021939456928521395,
-0.002195458859205246,
-0.005395593587309122,
0.016086917370557785,
0.0041306703351438046,
0.022817036136984825,
-0.020323503762483597,
0.013835475780069828,
0.000589717470575124,
0.002204537158831954,
0.0121287377551198,
-0.01579640991985798,
-0.007837682031095028,
-0.028808778151869774,
0.00037107945536263287,
-0.009005769155919552,
-0.01741841621696949,
-0.007571382448077202,
-0.028711941093206406,
0.03009185753762722,
0.006006872281432152,
0.0067482744343578815,
-0.013339189812541008,
0.013908103108406067,
0.043043702840805054,
-0.0651707798242569,
-0.0224175862967968,
0.00787399522960186,
-0.010573305189609528,
-0.01966985873878002,
0.013787057250738144,
-0.015614841133356094,
-0.020940834656357765,
0.02742886170744896,
-0.017914701253175735,
0.014840152114629745,
-0.03890395537018776,
0.00303218443877995,
-0.026315243914723396,
0.01991194859147072,
-0.04933805763721466,
-0.036943018436431885,
-0.046699270606040955,
-0.008297653868794441,
0.02919612266123295,
-0.011668764986097813,
-0.004312238190323114,
0.012237678281962872,
0.057133372873067856,
-0.009005769155919552,
0.018846750259399414,
-0.005810173694044352,
0.027549905702471733,
-0.05335675925016403,
-0.014065462164580822,
0.00525639159604907,
0.007050887681543827,
-0.023966966196894646,
0.0310360100120306,
-0.037475619465112686,
-0.030285529792308807,
0.04318895563483238,
-0.018326256424188614,
-0.02310754358768463,
0.023385949432849884,
0.01678897999227047,
0.009816772304475307,
-0.015336437150835991,
0.014815942384302616,
0.007686375640332699,
-0.0028717992827296257,
-0.01987563632428646,
-0.015421168878674507,
-0.01793891005218029,
0.008666842244565487,
-0.005837408825755119,
-0.04009019583463669,
-0.027985669672489166,
0.015626946464180946,
0.011220897547900677,
-0.02012982964515686,
-0.019512498751282692,
0.025855273008346558,
0.014779629185795784,
0.01799943298101425,
-0.06313721835613251,
0.03926708921790123,
0.030745502561330795,
-0.01110590435564518,
-0.022974394261837006,
-0.0005636170972138643,
0.004790367092937231,
0.029438212513923645,
-0.03926708921790123,
0.006312511395663023,
-0.02117081917822361,
0.02805829606950283,
-0.020783474668860435,
0.03582940250635147,
-0.0015289532020688057,
-0.0009509620140306652,
-0.032827481627464294,
0.005577161442488432,
0.015626946464180946,
0.015493796207010746,
-0.0054288809187710285,
-0.03604728356003761,
0.002496558940038085,
-0.006188440136611462,
-0.01736999861896038,
-0.019221991300582886,
-0.020141934975981712,
0.003876475151628256,
0.01856834627687931,
-0.02951084077358246,
0.012286095879971981,
-0.026145780459046364,
-0.013230249285697937,
0.0029368612449616194,
-0.007819524966180325,
-0.007637957111001015,
-0.03609570488333702,
-0.0007440501940436661,
0.026145780459046364,
-0.014162298291921616,
0.03711248189210892,
-0.027404652908444405,
-0.033553753048181534,
-0.013000263832509518,
-0.03713669255375862,
0.005928192753344774,
0.01509434636682272,
0.003855292219668627,
0.0057647814974188805,
-0.010597514919936657,
0.04292265698313713,
0.007414023391902447,
-0.011541667394340038,
-0.0038431878201663494,
0.0054107243195176125,
0.012122685089707375,
0.020190352573990822,
0.006548549979925156,
0.00400357274338603,
-0.01048252172768116,
0.06158784031867981,
0.012976054102182388,
0.0018232446163892746,
-0.02878456749022007,
0.005894905421882868,
-0.01235872320830822,
0.006905633490532637,
0.015421168878674507,
-0.032415926456451416,
0.014477015472948551,
0.03478841483592987,
0.004363682586699724,
0.00339532014913857,
0.030842337757349014,
-0.027210978791117668,
0.05204947292804718,
0.027719369158148766,
0.04754658788442612,
-0.009429427795112133,
0.022853350266814232,
0.002814302919432521,
-0.007177985273301601,
-0.004790367092937231,
-0.02117081917822361,
0.006766431499272585,
0.011977430433034897,
-0.034183189272880554,
0.004100408870726824,
0.037524037063121796,
0.025927899405360222,
-0.013702326454222202,
0.03135072812438011,
0.041324861347675323,
0.03411056101322174,
0.008860514499247074,
0.03185911849141121,
0.03118126466870308,
-0.02696888893842697,
-0.02476586401462555,
-0.010591462254524231,
-0.029873976483941078,
0.05534190312027931,
-0.02383381687104702,
-0.018907273188233376,
-0.002419392578303814,
0.002162171294912696,
-0.0018156792502850294,
0.002964096376672387,
0.04108276963233948,
0.009266016073524952,
0.018314151093363762,
-0.023543307557702065,
0.023228589445352554,
-0.0044453879818320274,
-0.00033684633672237396,
0.026993097737431526,
0.021558165550231934,
0.017866283655166626,
-0.015179078094661236,
0.020432444289326668,
-0.01622006855905056,
0.000589717470575124,
0.05020958185195923,
0.002375513780862093,
0.03125389292836189,
-0.0380566380918026,
0.019125154241919518,
-0.04144590348005295,
-0.006736170034855604,
0.018689392134547234,
-0.01475542038679123,
-0.011263263411819935,
0.006118839140981436,
0.05524506792426109,
0.02195761352777481,
-0.018398882821202278,
-0.03469157963991165,
0.02711414359509945,
-0.038153473287820816,
-0.02075926586985588,
-0.04040491580963135,
0.054421957582235336,
0.02733202464878559,
-0.06304038316011429,
-0.00574965076521039,
-0.002805224386975169,
0.02414853312075138,
-0.030624456703662872,
-0.020057203248143196,
0.07746898382902145,
-0.01285500917583704,
0.025225836783647537,
-0.037160903215408325,
0.005038510076701641,
0.017224743962287903,
-0.017297370359301567,
0.00779531616717577,
-0.008218974806368351,
-0.008739469572901726,
-0.01074276864528656,
-0.023906443268060684,
-0.012267939746379852,
-0.01431965734809637,
-0.0004058799531776458,
-0.037524037063121796,
0.014840152114629745,
0.02403959259390831,
0.03367479890584946,
-0.019415663555264473,
0.014840152114629745,
-0.023918548598885536,
0.026678379625082016,
0.024184847250580788,
0.005710311233997345,
0.0022544683888554573,
-0.007595591712743044,
-0.019996680319309235,
-0.030212903395295143,
-0.004197244998067617,
-0.04076804965734482,
0.0432857945561409,
0.019851425662636757,
-0.016462158411741257,
-0.03677355870604515,
0.009272068738937378,
0.00016435679572168738,
0.05824698880314827,
-0.023543307557702065,
-0.019367245957255363,
0.004757079761475325,
-0.002921730512753129,
0.0007066018297336996,
0.016595307737588882,
0.032246463000774384,
0.039920736104249954,
0.007522964384406805,
-0.007420076057314873,
0.004511963110417128,
0.043939437717199326,
0.001898897928185761,
0.0056528146378695965,
-0.01590535044670105,
0.025153210386633873,
-0.02440272830426693,
0.04507726430892944,
-0.02102556638419628,
-0.0011854872573167086,
0.003398346249014139,
-0.005976610817015171,
0.022199705243110657,
0.03556310385465622,
0.036168329417705536,
-0.008049511350691319,
-0.0032319091260433197,
0.01726105809211731,
-0.014997510239481926,
0.030914966017007828,
0.005955427885055542,
0.0075774346478283405,
-0.013012368232011795,
-0.019948262721300125,
0.009786510840058327,
-0.002622143365442753,
0.019790904596447945,
0.018943587318062782,
0.0009138918831013143,
-0.026363663375377655,
-0.01450122520327568,
0.026823634281754494,
-0.02101346105337143,
-0.041687995195388794,
0.030527619644999504,
-0.0013844554778188467,
0.0022015110589563847,
-0.021655000746250153,
-0.02805829606950283,
0.0005760999047197402,
0.006669594906270504,
-0.014634374529123306,
-0.01762419380247593,
0.03014027513563633,
0.012661336921155453,
-0.03168965503573418,
-0.03706406429409981,
0.0273804422467947,
-0.03365058824419975,
-0.03696722909808159,
-0.04391522705554962,
0.06231411173939705,
-0.006536445114761591,
-0.06212043762207031,
-0.016341112554073334,
0.046069834381341934,
-0.006379086524248123,
0.027089934796094894,
-0.0022711120545864105,
-0.0032500659581273794,
0.04803076758980751,
0.008430804125964642,
0.0005923653370700777,
-0.007438232656568289,
0.01689792238175869,
0.012612918391823769,
0.013000263832509518,
-0.03938813507556915,
0.0011907829903066158,
0.010052810423076153,
-0.019754590466618538,
-0.004203297663480043,
-0.011099852621555328,
0.0009910583030432463,
-0.01095459796488285,
-0.001207426656037569,
-0.022151287645101547,
0.00004652678035199642,
0.007323239464312792,
-0.011571928858757019,
-0.025322673842310905,
0.012709754519164562,
0.02273230440914631,
-0.00990755669772625,
0.0051595550030469894,
0.011051434092223644,
0.01736999861896038,
-0.012661336921155453,
0.0195488128811121,
0.0021303968969732523,
0.007486650720238686,
-0.009060239419341087,
-0.019694067537784576,
0.05054850876331329,
-0.024838492274284363,
-0.015554319135844707,
0.04050175100564957,
0.017503147944808006,
-0.013629699125885963,
-0.00020312912238296121,
0.013750744052231312,
-0.0006207353435456753,
-0.007177985273301601,
-0.021291865035891533,
0.024136429652571678,
0.020008785650134087,
-0.02919612266123295,
0.004781288560479879,
0.026726799085736275,
-0.01799943298101425,
-0.021110298112034798,
0.006736170034855604,
0.0038129263557493687,
0.02309544011950493,
0.015009614638984203,
-0.0312780998647213,
-0.01924620009958744,
-0.007371657527983189,
0.016655830666422844,
0.024596400558948517,
0.013157621957361698,
-0.007401918992400169,
0.041324861347675323,
0.0032046737615019083,
-0.007492702919989824,
-0.004248689394444227,
-0.011699026450514793,
-0.0006914711557328701,
-0.03035815618932247,
-0.02784041501581669,
-0.00875762663781643,
0.012661336921155453,
-0.024499565362930298,
0.013121308758854866,
-0.0417122058570385,
0.01632900908589363,
-0.01321814488619566,
0.002148553729057312,
0.02023877203464508,
0.003867396852001548,
0.0056043965741992,
-0.018314151093363762,
-0.009060239419341087,
-0.034401070326566696,
-0.009374957531690598,
0.015554319135844707,
-0.0012013744562864304,
0.013000263832509518,
0.030600247904658318,
0.020045097917318344,
0.022453900426626205,
-0.005761755630373955,
0.0008503430872224271,
0.02206655591726303,
0.018689392134547234,
-0.05054850876331329,
0.013629699125885963,
-0.024838492274284363,
0.004999170079827309,
0.004493806045502424,
-0.017805760726332664,
-0.003510313108563423,
0.002543464070186019,
-0.0038431878201663494,
-0.01235872320830822,
0.014222820289433002,
0.005120215471833944,
-0.005743598565459251,
0.006905633490532637,
0.011414569802582264,
-0.011844281107187271,
-0.026920471340417862,
0.020662430673837662,
0.020299293100833893,
0.015251705422997475,
0.0023815659806132317,
-0.02341015823185444,
-0.03602307662367821,
0.014852256514132023,
-0.025952108204364777,
0.0027008228935301304,
-0.019318826496601105,
0.016450053080916405,
0.002199998125433922,
-0.025322673842310905,
0.023301217705011368,
0.01152351126074791,
0.01940355822443962,
0.002419392578303814,
0.014428597874939442,
-0.015566423535346985,
-0.00792846642434597,
0.046965569257736206,
0.0182536281645298,
0.017503147944808006,
-0.026508916169404984,
-0.0009335617651231587,
-0.03873449191451073,
0.030164483934640884,
-0.028978241607546806,
0.0009055700502358377,
0.010591462254524231,
0.019597230479121208,
-0.02941400371491909,
-0.022151287645101547,
0.02022666670382023,
0.023349635303020477,
0.018689392134547234,
-0.0007769594085402787,
0.010434103198349476,
0.030212903395295143,
-0.03779033571481705,
-0.01883464679121971,
0.018907273188233376,
0.020735057070851326,
0.029535049572587013,
-0.015626946464180946,
0.00679064029827714,
-0.023906443268060684,
0.041324861347675323,
0.009114709682762623,
0.027913041412830353,
0.0036374107003211975,
-0.03936392441391945,
0.004303159657865763,
-0.007970832288265228,
-0.0059191142208874226,
0.0009706318378448486,
0.02315596304833889,
0.01027674414217472,
-0.037160903215408325,
0.058440662920475006,
0.004911412484943867,
0.014985405839979649,
-0.002985279308632016,
-0.023446470499038696,
-0.014767524786293507,
-0.02071084827184677,
0.0006710448069497943,
-0.00018818759417627007,
0.009247859939932823,
-0.019899845123291016,
-0.012213469482958317,
-0.0044877538457512856,
0.0009736579959280789,
0.006161205004900694,
-0.01350865326821804,
-0.008297653868794441,
0.0007115193293429911,
-0.056503936648368835,
-0.05432512238621712,
0.009423375129699707,
0.013411817140877247,
-0.03135072812438011,
-0.011971378698945045,
-0.03604728356003761,
0.005692154634743929,
0.018967796117067337,
-0.016244277358055115,
-0.01272185891866684,
0.0589248426258564,
0.018967796117067337,
-0.025492137297987938,
0.0025464901700615883,
0.018471509218215942,
0.02003299444913864,
-0.02805829606950283,
-0.010585409589111805,
-0.03674934804439545,
-0.009853086434304714,
0.024935327470302582,
-0.011408518068492413,
0.008255288004875183,
0.027719369158148766,
-0.0072021945379674435,
0.006536445114761591,
-0.005322966258972883,
0.0016779901925474405,
0.04757079482078552,
-0.013000263832509518,
-0.012927636504173279,
-0.002741675591096282,
-0.0005220077582634985,
-0.04376997426152229,
0.0013201500987634063,
0.027138352394104004,
0.006215675268322229,
-0.00405501713976264,
0.04752237722277641,
0.02058980241417885,
-0.04938647523522377,
-0.011941117234528065,
0.03222225606441498,
0.03222225606441498,
-0.01747893914580345,
-0.008636580780148506,
0.0010500678326934576,
-0.03185911849141121,
-0.03655567392706871,
0.01600218564271927,
-0.002942913444712758,
-0.024378519505262375,
-0.00011773544974857941,
0.02086820639669895,
-0.014307552017271519,
0.01965775340795517,
0.010651985183358192,
0.029535049572587013,
0.004708661697804928,
-0.02299860306084156,
-0.02774357795715332,
-0.03655567392706871,
-0.009011820890009403,
-0.030745502561330795,
-0.01830204762518406,
0.00362530630081892,
0.004514988977462053,
-0.03740299120545387,
0.01747893914580345,
0.00538651505485177,
0.007147723808884621,
-0.0050506144762039185,
0.03139914572238922,
-0.010942493565380573,
-0.009272068738937378,
-0.004850889556109905,
0.02148553729057312,
-0.010095176286995411,
-0.005761755630373955,
-0.02883298695087433,
0.01382337138056755,
0.008618423715233803,
-0.002544977003708482,
-0.04708661511540413,
0.00041193224024027586,
0.023809606209397316,
0.003283353289589286,
0.004530119709670544,
0.018168896436691284,
-0.020686639472842216,
0.006796692498028278,
-0.04350367560982704,
-0.0048024714924395084,
-0.028203550726175308,
0.01027674414217472,
0.01152351126074791,
-0.0004909899435006082,
0.014162298291921616,
-0.01647426374256611,
0.017696820199489594,
-0.03188332915306091,
-0.037209320813417435,
-0.004817602224647999,
-0.04180904105305672,
0.00022639251255895942,
0.012243730016052723,
0.004306185990571976,
-0.0028369987849146128,
0.023071231320500374,
-0.029486630111932755,
-0.007256664801388979,
0.020505070686340332,
-0.006227779667824507,
0.02288966253399849,
0.016595307737588882,
-0.008576057851314545,
-0.013181831687688828,
0.0029928446747362614,
0.018955690786242485,
-0.010549096390604973,
0.004663269501179457,
0.03733036667108536,
-0.023301217705011368,
-0.009762302041053772,
0.010010444559156895,
-0.0008556388202123344,
-0.028615104034543037,
0.011360099539160728,
-0.011184584349393845,
0.011674817651510239,
0.010718559846282005,
-0.04645717889070511,
0.00998623576015234,
-0.006152126472443342,
0.0044847275130450726,
0.005934244953095913,
0.008279497735202312,
-0.023446470499038696,
0.022913871333003044,
-0.029268749058246613,
-0.012915532104671001,
0.014949092641472816,
-0.007256664801388979,
-0.0036374107003211975,
0.036628302186727524,
-0.0033620328176766634,
0.0052957311272621155,
0.03360217064619064,
0.009114709682762623,
-0.01803574711084366,
0.030382366850972176,
-0.027985669672489166,
-0.00101375428494066,
0.0294624213129282,
0.007050887681543827,
-0.004971934948116541,
0.030116066336631775,
0.0005197381833568215,
-0.004139748867601156,
0.02779199741780758,
0.03132651746273041,
-0.0061460742726922035,
-0.002440575510263443,
-0.02575843594968319,
0.00832186359912157,
-0.010524887591600418,
0.031568609178066254,
0.1304384022951126,
-0.01092433650046587,
0.017757343128323555,
0.010760925710201263,
0.01704317517578602,
-0.019488289952278137,
0.01883464679121971,
0.01663162186741829,
0.011263263411819935,
-0.02430589310824871,
0.024317996576428413,
0.021340282633900642,
0.03076971136033535,
0.03718511015176773,
0.04735291376709938,
-0.004288028925657272,
0.009169179946184158,
0.03904920816421509,
-0.0041094874031841755,
-0.010367528535425663,
0.022829139605164528,
0.0038613444194197655,
-0.016522681340575218,
0.02900245040655136,
-0.03503050655126572,
-0.012661336921155453,
-0.004536171909421682,
-0.0007478328770957887,
-0.012019796296954155,
-0.013436025939881802,
0.029220331460237503,
-0.005534795578569174,
0.009962026961147785,
-0.029268749058246613,
-0.010228326544165611,
-0.03207699954509735,
-0.02065032534301281,
-0.022925976663827896,
0.005976610817015171,
0.004965882748365402,
0.004345525521785021,
0.033190615475177765,
0.002746214857324958,
0.007601643912494183,
0.004962856415659189,
-0.007286925800144672,
-0.020626116544008255,
-0.011650608852505684,
-0.00027140622842125595,
-0.0260731540620327,
0.020468756556510925,
-0.008624476380646229,
0.021255550906062126,
-0.0027083882596343756,
-0.029292957857251167,
-0.018798332661390305,
-0.0013095586327835917,
0.010833553038537502,
0.010621723718941212,
-0.016074813902378082,
-0.00779531616717577,
0.03967864438891411,
-0.0024693238083273172,
0.007171933073550463,
-0.03403793275356293
] | 2025-01-16 | 63 | 39814734 | [
"anti-HER2 CAR",
"T cell anti-tumor immunity",
"non-responsive tumors",
"macrophage anti-tumor function",
"tumor control",
"tumor growth control",
"solid tumors",
"pre-clinical models",
"intratumoral T cell",
"tumor burden",
"M",
"long-term anti-tumor immunity",
"immunodeficient xenograft models",
"aPD1 therapy",
"TME",
"CAR-M and T cell checkpoint blockade",
"prolong survival",
"a T cell dependent fashion",
"CAR-M",
"human CAR macrophages",
"HER2+ solid tumors",
"anti-PD1 (aPD1) monotherapy",
"CAR-M therapy",
"survival",
"antigen",
"limited sensitivity",
"natural killer",
"the tumor microenvironment",
"NK) cell infiltration",
"HER2"
] | [] | 0 | 10.1038/s41467-024-55770-1 | [
"Pierini",
"Gabbasov",
"Oliveira-Nunes",
"Qureshi",
"Worth",
"Huang",
"Nagar",
"Griffin",
"Lian",
"Yashiro-Ohtani",
"Ross",
"Sloas",
"Ball",
"Schott",
"Sonawane",
"Cornell",
"Blumenthal",
"Chhum",
"Minutolo",
"Ciccaglione",
"Shaw",
"Zentner",
"Levitsky",
"Shestova",
"Gill",
"Varghese",
"Cushing",
"Ceeraz DeLong",
"Abramson",
"Condamine",
"Klichinsky"
] | [
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.",
"Center for Cellular Immunotherapies, Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA.",
"Carisma Therapeutics Inc, Philadelphia, PA, USA. [email protected]."
] | [
"39814734",
"29567707",
"37723178",
"38012418",
"32361713",
"38168956",
"35152151",
"25704439",
"25891173",
"35070955",
"30881032",
"26755520",
"35108529",
"37322116",
"25428505",
"35697799",
"29070816",
"29360728",
"30765258",
"34534429",
"29863979",
"27093365",
"37871604",
"34912120",
"33002436",
"20980503",
"24198409",
"26045163",
"17404308",
"33545035",
"24145359",
"25597333",
"28460461",
"37153626",
"30804938",
"33203697",
"33214663",
"34603327",
"32793604",
"25082815",
"28436425",
"31269428",
"27339708",
"25035953",
"8790399",
"18329760",
"20819927",
"21555851",
"25754329",
"36550555",
"12610629",
"10403450",
"26378078",
"19706884",
"24157944",
"21945395",
"25653453",
"23104886",
"25516281",
"20979621",
"30643263",
"18800157",
"26084029"
] | [] | 10.248337 | 5.510309 |
39814310 | 27 | Unlocking the potential of chimeric antigen receptor T cell engineering immunotherapy: Long road to achieve precise targeted therapy for hepatobiliary pancreatic cancers. | Innovative therapeutic strategies are urgently needed to address the ongoing global health concern of hepatobiliary pancreatic malignancies. This review summarizes the latest and most comprehensive research of chimeric antigen receptor (CAR-T) cell engineering immunotherapy for treating hepatobiliary pancreatic cancers. Commencing with an exploration of the distinct anatomical location and the immunosuppressive, hypoxic tumor microenvironment (TME), this review critically assesses the limitations of current CAR-T therapy in hepatobiliary pancreatic cancers and proposes corresponding solutions. Various studies aim at enhancing CAR-T cell efficacy in these cancers through improving T cell persistence, enhancing antigen specificity and reducing tumor heterogeneity, also modulating the immunosuppressive and hypoxic TME. Additionally, the review examines the application of emerging nanoparticles and biotechnologies utilized in CAR-T therapy for these cancers. The results suggest that constructing optimized CAR-T cells to overcome physical barrier, manipulating the TME to relieve immunosuppression and hypoxia, designing CAR-T combination therapies, and selecting the most suitable delivery strategies, all together could collectively enhance the safety of CAR-T engineering and advance the effectiveness of adaptive cell therapy for hepatobiliary pancreatic cancers. | [
0.010244160890579224,
0.006129745859652758,
0.06155918911099434,
0.06758947670459747,
-0.026508141309022903,
-0.012238552793860435,
0.019033096730709076,
0.056952718645334244,
0.004792299121618271,
0.0062658460810780525,
-0.03348065912723541,
-0.004090859554708004,
-0.03036082349717617,
0.0004501777293626219,
0.018624795600771904,
-0.0246027372777462,
0.03881997987627983,
0.0006507292855530977,
0.047446638345718384,
0.005690037272870541,
0.03766836225986481,
-0.028225097805261612,
-0.009406620636582375,
0.005789495073258877,
-0.06377866864204407,
0.012238552793860435,
-0.004182465374469757,
0.006532812025398016,
-0.046818483620882034,
-0.020739583298563957,
0.03369004651904106,
-0.017211446538567543,
-0.021587593480944633,
-0.008181719109416008,
-0.02426772005856037,
0.03274781256914139,
0.02539839968085289,
0.009207705035805702,
-0.006145449820905924,
-0.002377828350290656,
0.08119950443506241,
0.04275641590356827,
0.03473697230219841,
0.07910565286874771,
-0.04091382771730423,
-0.016279682517051697,
0.00651710806414485,
-0.05900469049811363,
0.019409989938139915,
-0.020990846678614616,
-0.031344935297966,
0.023095164448022842,
-0.028832314535975456,
-0.002667041262611747,
-0.027952896431088448,
0.009793982841074467,
-0.028560113161802292,
0.0032768752425909042,
-0.013452986255288124,
0.04292392358183861,
-0.005998880136758089,
-0.011872129514813423,
0.016279682517051697,
-0.0003513741830829531,
-0.07709555327892303,
0.011568521149456501,
-0.03768929839134216,
-0.022404193878173828,
0.011914006434381008,
-0.016080766916275024,
0.009202471002936363,
0.004669285379350185,
0.005988410674035549,
0.015484020113945007,
0.04062068834900856,
-0.0057842605747282505,
-0.014908211305737495,
0.02456085942685604,
0.0067893085069954395,
-0.023388303816318512,
0.0212316382676363,
0.0005025239661335945,
0.018373534083366394,
-0.043970849364995956,
-0.014374280348420143,
0.002303234999999404,
0.009762575849890709,
-0.01453131902962923,
-0.0533931739628315,
-0.029041698202490807,
-0.0030072920490056276,
0.029460469260811806,
-0.017378954216837883,
0.046734731644392014,
-0.00935950968414545,
0.009678821079432964,
-0.0123013686388731,
-0.056240808218717575,
0.03291532024741173,
0.04974987357854843,
0.05272314324975014,
-0.013756594620645046,
-0.045645929872989655,
0.007338943891227245,
0.04049505665898323,
-0.0073232403956353664,
-0.06629128754138947,
-0.008281176909804344,
0.008684243075549603,
-0.009432793594896793,
0.05192747712135315,
-0.014395218342542648,
0.0050749690271914005,
0.041897937655448914,
-0.042400460690259933,
-0.055403269827365875,
-0.02914639189839363,
-0.0017169569618999958,
0.0025178545620292425,
0.04388709366321564,
-0.04811667278409004,
0.01284576952457428,
0.03798243775963783,
-0.003067490179091692,
0.004090859554708004,
-0.05192747712135315,
0.05402132868766785,
-0.02548215351998806,
-0.022194810211658478,
-0.07303348928689957,
0.017944294959306717,
0.034339141100645065,
0.023744259029626846,
-0.04757227003574371,
-0.04715350270271301,
-0.014981496147811413,
-0.04966612160205841,
0.010668165050446987,
-0.0243933517485857,
-0.027052542194724083,
0.023157980293035507,
-0.019483273848891258,
-0.017577869817614555,
-0.027303803712129593,
-0.039259687066078186,
-0.05766462907195091,
-0.0018124888883903623,
0.04803291708230972,
-0.012060576118528843,
0.055989548563957214,
-0.036391112953424454,
0.028790436685085297,
0.05012676864862442,
0.0035700141452252865,
-0.0036537682171911,
-0.03452758491039276,
0.01585044339299202,
0.08245581388473511,
-0.04260984808206558,
-0.07056274265050888,
-0.012437468394637108,
-0.0006464761681854725,
-0.033920370042324066,
-0.018415410071611404,
0.040013473480939865,
-0.03281062841415405,
-0.018907465040683746,
0.029753608629107475,
-0.0533931739628315,
-0.028078528121113777,
-0.0386943481862545,
-0.06407181173563004,
-0.06423931568861008,
0.016876431182026863,
-0.02694784849882126,
0.01469882670789957,
0.012238552793860435,
0.010254629887640476,
-0.034381017088890076,
-0.01301327720284462,
-0.001957749715074897,
0.04769790172576904,
0.028392605483531952,
0.011683682911098003,
-0.036432988941669464,
0.057287734001874924,
0.005642925854772329,
-0.005318379029631615,
-0.05343504995107651,
-0.03111460991203785,
0.023744259029626846,
-0.0028607225976884365,
0.022152932360768318,
0.01478258054703474,
-0.01328547764569521,
0.00863189622759819,
0.01626921445131302,
0.020676767453551292,
-0.021461961790919304,
-0.02956516109406948,
0.04907984286546707,
-0.008940739557147026,
-0.03691457584500313,
0.014206771738827229,
-0.012803892605006695,
-0.020634891465306282,
-0.016028420999646187,
0.04325893893837929,
0.01842587999999523,
0.008961677551269531,
0.025628723204135895,
0.0043211826123297215,
-0.014939619228243828,
0.032056841999292374,
-0.020540667697787285,
-0.035930465906858444,
-0.014730234630405903,
0.046734731644392014,
0.032056841999292374,
-0.010631523095071316,
-0.01211292203515768,
-0.0016659193206578493,
0.011432420462369919,
0.016405314207077026,
-0.02068723738193512,
-0.006260611582547426,
0.010306976735591888,
-0.004140588454902172,
0.0076006753370165825,
-0.01738942414522171,
-0.0037610779982060194,
-0.0004694804083555937,
0.015567773953080177,
-0.020237060263752937,
-0.03082147054374218,
-0.03241279721260071,
0.017609277740120888,
-0.016918307170271873,
0.03410881757736206,
-0.01743130013346672,
0.041144151240587234,
0.03775211423635483,
0.03304095193743706,
-0.054733239114284515,
-0.03561638668179512,
-0.0022129376884549856,
-0.014520849101245403,
-0.05933970585465431,
0.017159100621938705,
0.008160780183970928,
-0.007030101027339697,
-0.015253696590662003,
-0.023869888857007027,
-0.015086188912391663,
0.03251748904585838,
-0.0019315766403451562,
0.021964486688375473,
-0.035344187170267105,
0.025126200169324875,
-0.011767436750233173,
0.0027743512764573097,
0.03356441482901573,
-0.05209498852491379,
-0.0492054745554924,
-0.05000113695859909,
0.013442516326904297,
0.006569454446434975,
-0.00042106013279408216,
0.03073771670460701,
-0.009621240198612213,
0.05058741569519043,
0.03124024160206318,
0.05368631333112717,
-0.028643867000937462,
-0.06093103438615799,
0.007328474894165993,
0.0024628909304738045,
0.03632829710841179,
-0.0346950925886631,
0.039050303399562836,
-0.002250888617709279,
0.0005895495996810496,
-0.005297440569847822,
-0.015672467648983,
0.0033527773339301348,
-0.0212316382676363,
0.007815294899046421,
0.010348853655159473,
0.03308282792568207,
-0.042400460690259933,
0.03789868578314781,
-0.009144890122115612,
-0.009537486359477043,
-0.010856611654162407,
0.027282865718007088,
-0.016792677342891693,
0.0038657705299556255,
-0.023199858143925667,
-0.003486260073259473,
0.0169287770986557,
-0.040557872503995895,
-0.01471976563334465,
-0.009464201517403126,
-0.03333409130573273,
0.05439822003245354,
-0.011013650335371494,
-0.019734535366296768,
-0.00805085338652134,
0.025461215525865555,
0.03023519366979599,
0.038757164031267166,
-0.04769790172576904,
0.03570014238357544,
0.007459340617060661,
0.002732474124059081,
0.022006362676620483,
0.03285250440239906,
-0.0634855329990387,
-0.03094710223376751,
-0.05879530683159828,
-0.04057881236076355,
0.02376519702374935,
-0.045562174171209335,
0.01255263015627861,
0.01330641657114029,
-0.009432793594896793,
0.03683082014322281,
-0.007490748073905706,
0.034841664135456085,
-0.01943092793226242,
-0.018111802637577057,
-0.040767259895801544,
0.05025240033864975,
-0.020247528329491615,
0.0006765752914361656,
-0.007218547631055117,
-0.040976643562316895,
-0.054775115102529526,
0.03806619346141815,
0.0030988978687673807,
0.008977381512522697,
0.038799040019512177,
-0.03800337761640549,
0.07629989087581635,
-0.013065624050796032,
-0.028015712276101112,
0.016907839104533195,
0.03775211423635483,
-0.0021854559890925884,
0.05104806274175644,
0.002322864718735218,
0.02573341503739357,
0.010992712341248989,
0.0016318942653015256,
-0.02615218609571457,
0.06277362257242203,
-0.03729146718978882,
-0.01228042971342802,
-0.017494115978479385,
-0.03086334839463234,
0.020446443930268288,
-0.005559171549975872,
-0.03982502594590187,
0.013976448215544224,
0.05259751155972481,
0.05946533754467964,
-0.011903537437319756,
0.02694784849882126,
-0.05377006530761719,
-0.014876804314553738,
-0.006176857277750969,
0.010793796740472317,
0.013348293490707874,
0.0028868955560028553,
-0.019158726558089256,
0.028539175167679787,
0.02064536139369011,
-0.01609123684465885,
0.0002191999228671193,
-0.0083596957847476,
0.03902936354279518,
-0.02160853147506714,
0.0023961495608091354,
-0.0033737157937139273,
-0.0123013686388731,
0.0010063566733151674,
0.039552826434373856,
-0.02106413058936596,
-0.06658443063497543,
0.01610170677304268,
-0.01972406730055809,
-0.013808940537273884,
0.019493743777275085,
0.0014212006935849786,
0.011264912784099579,
0.07558798044919968,
-0.028434481471776962,
0.08568034321069717,
0.06398805230855942,
0.014353341422975063,
0.0047373357228934765,
-0.026215001940727234,
-0.016530945897102356,
-0.0309052262455225,
0.02977454662322998,
-0.02998393215239048,
0.0584602914750576,
0.021734163165092468,
0.02414209023118019,
-0.031344935297966,
0.011788375675678253,
0.005470183212310076,
0.0213468000292778,
0.015347920358181,
0.010521596297621727,
-0.04309143126010895,
-0.01652047596871853,
0.041562922298908234,
-0.02468649111688137,
0.0355326347053051,
0.021964486688375473,
-0.029753608629107475,
0.004106563050299883,
0.0037610779982060194,
-0.003996636252850294,
-0.004323800094425678,
0.01876089535653591,
0.011830252595245838,
-0.002657880773767829,
-0.055905792862176895,
-0.06151731312274933,
0.05992598459124565,
-0.004514864180237055,
-0.01738942414522171,
-0.025042446330189705,
0.02981642261147499,
-0.02868574485182762,
0.021116476505994797,
-0.03641204908490181,
0.040515996515750885,
-0.029586099088191986,
-0.015473551116883755,
0.008532438427209854,
-0.014929150231182575,
0.014248648658394814,
-0.004446813836693764,
0.02031034417450428,
0.04719537869095802,
-0.04304955527186394,
-0.010573942214250565,
0.015274635516107082,
-0.027408495545387268,
0.0034365311730653048,
0.010359322652220726,
-0.024414289742708206,
-0.0012870633509010077,
0.018080394715070724,
-0.06947394460439682,
-0.00821836106479168,
0.02160853147506714,
0.06201983615756035,
-0.040139105170965195,
0.018635263666510582,
-0.04451524838805199,
0.027743512764573097,
0.030277069658041,
0.03297813609242439,
-0.016248276457190514,
-0.023555811494588852,
-0.03683082014322281,
0.024749306961894035,
-0.023828012868762016,
-0.02343018166720867,
0.005967472214251757,
0.006187326740473509,
0.030130499973893166,
0.0032742577604949474,
0.024204906076192856,
-0.006825950928032398,
-0.00330043095164001,
-0.045269034802913666,
-0.019619373604655266,
-0.02109553851187229,
0.0020192565862089396,
0.03180558234453201,
0.009354274719953537,
-0.015169942751526833,
-0.003119836328551173,
-0.028748560696840286,
0.041646674275398254,
-0.01311796996742487,
-0.0028005242347717285,
-0.013212192803621292,
-0.006438588723540306,
-0.00965788308531046,
0.010008602403104305,
-0.04895421117544174,
-0.027157234027981758,
-0.015578243881464005,
0.044389620423316956,
0.006093103438615799,
0.027010664343833923,
0.021587593480944633,
0.029251083731651306,
0.035553570836782455,
0.034506648778915405,
0.019870636984705925,
0.06691944599151611,
0.015798097476363182,
0.023178918287158012,
-0.04849356412887573,
-0.0382755771279335,
0.028999822214245796,
-0.0021435788366943598,
-0.03243373706936836,
-0.0034182099625468254,
-0.06482559442520142,
-0.026382509618997574,
0.008872688747942448,
-0.014196302741765976,
0.013735655695199966,
-0.014813988469541073,
-0.011620867066085339,
0.008830811828374863,
0.017148630693554878,
-0.005679567810148001,
-0.045645929872989655,
-0.015703875571489334,
-0.02447710558772087,
-0.01543167419731617,
0.016206398606300354,
-0.014960558153688908,
-0.012144329957664013,
0.019493743777275085,
-0.04217013716697693,
-0.019525151699781418,
-0.02990017645061016,
0.008977381512522697,
-0.019577497616410255,
-0.013358762487769127,
0.0019642929546535015,
-0.01434287242591381,
0.002134418347850442,
0.01175696775317192,
-0.006260611582547426,
0.011432420462369919,
0.015368858352303505,
-0.008542907424271107,
0.0037610779982060194,
-0.009998133406043053,
-0.009940552525222301,
-0.06373678892850876,
0.004554123617708683,
0.01061058510094881,
0.01559918187558651,
-0.04286110773682594,
-0.0011921857949346304,
-0.04887045919895172,
-0.002154048066586256,
-0.01922154240310192,
-0.008720885030925274,
-0.005501590669155121,
0.016918307170271873,
-0.020917560905218124,
-0.020750053226947784,
0.045227158814668655,
-0.0044913082383573055,
-0.039720334112644196,
-0.022822964936494827,
0.002012713346630335,
-0.021378207951784134,
-0.016614699736237526,
0.03111460991203785,
-0.009762575849890709,
0.05389569699764252,
0.0023294079583138227,
-0.01593419723212719,
-0.005025239661335945,
-0.010772857815027237,
-0.0029183034785091877,
-0.022697333246469498,
-0.03389943018555641,
-0.022802025079727173,
0.06218734383583069,
0.0033187521621584892,
0.01984969712793827,
-0.027638819068670273,
-0.011421951465308666,
-0.022781087085604668,
0.004363059997558594,
0.03704020753502846,
-0.017023000866174698,
0.022885780781507492,
-0.005684802774339914,
-0.04418023303151131,
0.02535652369260788,
-0.0002757993061095476,
0.005135166924446821,
0.0011031972244381905,
0.016195928677916527,
-0.0036275950260460377,
-0.0003094972053077072,
0.003787251189351082,
-0.029376715421676636,
-0.055528901517391205,
-0.004224342294037342,
0.02405833639204502,
-0.010066183283925056,
0.022320440039038658,
-0.01718003861606121,
0.03590952605009079,
0.06122417375445366,
-0.021126946434378624,
0.0073965247720479965,
0.044640880078077316,
0.0069934590719640255,
-0.012060576118528843,
0.006187326740473509,
0.013955510221421719,
0.004383998457342386,
0.018216494470834732,
-0.011065997183322906,
-0.008040383458137512,
-0.002513928571715951,
0.00002754312299657613,
-0.04857731983065605,
-0.018739957362413406,
-0.0055905794724822044,
0.03687269613146782,
-0.009652648121118546,
0.002563657471910119,
-0.02644532546401024,
-0.03136587142944336,
0.027073480188846588,
-0.0024262487422674894,
-0.024623675271868706,
0.034381017088890076,
-0.018384002149105072,
-0.013589086011052132,
0.0013400639872998,
-0.035092923790216446,
0.011589459143579006,
-0.014416157267987728,
-0.02914639189839363,
0.00849056150764227,
0.003062255447730422,
-0.02906263805925846,
-0.001655450090765953,
0.0038736225105822086,
-0.01876089535653591,
-0.011578990146517754,
-0.039678458124399185,
0.021880732849240303,
0.0014382131630554795,
0.014855865389108658,
-0.002414470771327615,
0.009835859760642052,
-0.0022770618088543415,
0.04296579957008362,
0.06214546784758568,
-0.018111802637577057,
0.02906263805925846,
-0.007710602600127459,
-0.0033213694114238024,
-0.005857545416802168,
-0.01219667587429285,
0.003546458436176181,
-0.009228643961250782,
0.012877177447080612,
-0.0005875866627320647,
0.0815763920545578,
0.021461961790919304,
0.008244534023106098,
-0.03974127396941185,
0.009040197357535362,
0.007427932694554329,
0.01488727331161499,
-0.011076466180384159,
-0.024874936789274216,
-0.0009540104074403644,
-0.020373160019516945,
0.01893887296319008,
-0.03266406059265137,
-0.0426936000585556,
0.007480279076844454,
-0.00660086190328002,
0.014646480791270733,
-0.003941672388464212,
0.007773417979478836,
-0.027596943080425262,
0.007082447409629822,
-0.005001684185117483,
-0.04861919581890106,
-0.0309052262455225,
0.006281550042331219,
0.01689736917614937,
0.008469623513519764,
-0.002494298852980137,
0.0006598898908123374,
-0.046734731644392014,
0.02135726995766163,
0.045143406838178635,
0.036642372608184814,
-0.03023519366979599,
0.029167329892516136,
-0.012584038078784943,
-0.008621427230536938,
-0.009872502647340298,
0.005192747805267572,
0.017002061009407043,
-0.027492249384522438,
-0.009992898441851139,
-0.003180034691467881,
-0.01906450465321541,
0.0083596957847476,
0.011296320706605911,
-0.00010959996143355966,
0.044808387756347656,
0.01255263015627861,
0.013379701413214207,
-0.002784820506349206,
0.0072290170937776566,
-0.008726119995117188,
0.010856611654162407,
0.020027674734592438,
0.0213468000292778,
-0.020802399143576622,
0.026675648987293243,
-0.016667045652866364,
-0.010202283971011639,
-0.009940552525222301,
-0.02686409465968609,
-0.027617881074547768,
-0.046022821217775345,
-0.0013151995372027159,
0.009045431390404701,
-0.021587593480944633,
-0.06105666607618332,
0.0212316382676363,
-0.012594507075846195,
0.01938905008137226,
-0.0271153561770916,
-0.025628723204135895,
0.0019014774588868022,
-0.011128812097012997,
0.02523089200258255,
0.024749306961894035,
0.023869888857007027,
0.02935577556490898,
-0.03224528953433037,
-0.00892503559589386,
0.00454365462064743,
-0.023116104304790497,
-0.01726379245519638,
0.025503091514110565,
-0.02544027753174305,
0.01236418355256319,
-0.012772484682500362,
-0.00517180934548378,
-0.018865587189793587,
-0.018279310315847397,
0.018289780244231224,
-0.017441770061850548,
-0.02544027753174305,
0.0006739579257555306,
-0.022257624194025993,
0.022006362676620483,
0.004271453712135553,
0.009202471002936363,
0.007490748073905706,
-0.005485886707901955,
-0.031261179596185684,
0.011851190589368343,
-0.03519761934876442,
0.004208638332784176,
0.0006438588607124984,
-0.008035149425268173,
0.01776631735265255,
-0.007904283702373505,
0.025042446330189705,
0.0007361191092059016,
0.03174276649951935,
-0.006946347188204527,
0.016939247027039528,
0.0036223605275154114,
-0.017117222771048546,
-0.006647973787039518,
0.029251083731651306,
-0.028622929006814957,
0.012259491719305515,
-0.010291272774338722,
0.054775115102529526,
-0.029753608629107475,
0.018216494470834732,
-0.009024493396282196,
0.03400412201881409,
0.021461961790919304,
-0.06750572472810745,
-0.017881479114294052,
0.006454292684793472,
0.017871009185910225,
-0.0025230892933905125,
0.015829505398869514,
-0.054481975734233856,
-0.008830811828374863,
0.0005051412736065686,
-0.005341934505850077,
0.011327728629112244,
-0.011620867066085339,
0.020331282168626785,
-0.003172182710841298,
-0.004499160218983889,
-0.012165267951786518,
-0.02405833639204502,
-0.05117369443178177,
0.010793796740472317,
0.0258590467274189,
-0.0015625355299562216,
0.00928098987787962,
0.00028626853600144386,
0.046315960586071014,
-0.004336886573582888,
0.001508880639448762,
0.0008715650183148682,
-0.0233464278280735,
-0.04966612160205841,
-0.035218555480241776,
-0.028371667489409447,
0.008317818865180016,
-0.03894560784101486,
0.022613579407334328,
-0.005069734062999487,
-0.04212826117873192,
0.023409241810441017,
-0.0075169214978814125,
-0.012374653480947018,
0.014908211305737495,
-0.007595440838485956,
0.01801757887005806,
0.028078528121113777,
0.005988410674035549,
-0.025251829996705055,
-0.01005047932267189,
-0.010411668568849564,
0.01545261312276125,
0.0073127709329128265,
0.02544027753174305,
0.004776595160365105,
-0.022341379895806313,
-0.03634923696517944,
-0.010076653212308884,
-0.004787064623087645,
-0.035930465906858444,
0.011453359387814999,
0.030465517193078995,
0.017462708055973053,
0.013620493933558464,
-0.02611030824482441,
0.03398318588733673,
0.03814994543790817,
-0.002400075551122427,
-0.021545715630054474,
-0.020551137626171112,
-0.056617703288793564,
0.011767436750233173,
-0.03760554641485214,
0.006354834418743849,
-0.016038890928030014,
0.01543167419731617,
-0.026885032653808594,
0.01630062237381935,
0.0026447942946106195,
-0.006815481465309858,
-0.013369232416152954,
0.006731727626174688,
-0.0020689854864031076,
0.018331656232476234,
-0.015368858352303505,
-0.015578243881464005,
-0.008045618422329426,
0.004391850437968969,
-0.022299502044916153,
-0.02389082871377468,
-0.0033946542534977198,
0.03440195322036743,
0.035679202526807785,
-0.004263602197170258,
-0.024916814640164375,
-0.011547582224011421,
-0.0008519351831637323,
0.001561226905323565,
0.005423071328550577,
-0.0128248305991292,
0.0016070298152044415,
0.0011784449452534318,
-0.0031460095196962357,
-0.014740703627467155,
0.018698079511523247,
-0.03549075499176979,
-0.012071045115590096,
-0.024372413754463196,
-0.016750799492001534,
-0.014520849101245403,
0.02506338432431221,
-0.0024236312601715326,
-0.001151617499999702,
-0.024456167593598366,
0.019462335854768753,
0.007150497753173113,
0.027094418182969093,
-0.03657956048846245,
-0.004054217133671045,
0.012908585369586945,
0.034087877720594406,
-0.029460469260811806,
0.007899048738181591,
-0.00007483877561753616,
0.07433167099952698,
-0.0005745000671595335,
-0.012249021790921688,
-0.009354274719953537,
-0.022529825568199158,
-0.02117929235100746,
-0.011955883353948593,
0.021545715630054474,
0.003999253269284964,
0.017420832067728043,
0.022131994366645813,
0.012709668837487698,
0.023492995649576187,
-0.0012059267610311508,
0.0017195743275806308,
0.047069747000932693,
0.01951468177139759,
0.02885325253009796,
0.006653208285570145,
0.01248981524258852,
0.015986545011401176,
-0.01175696775317192,
-0.014217240735888481,
-0.008752292953431606,
0.03540700301527977,
-0.01923201233148575,
-0.055403269827365875,
0.01063675805926323,
0.005642925854772329,
-0.008317818865180016,
-0.0171381626278162,
0.017912887036800385,
0.03473697230219841,
0.06717070937156677,
0.009971960447728634,
-0.006674146745353937,
0.027303803712129593,
0.003507198765873909,
-0.03754273056983948,
0.022843902930617332,
-0.026550017297267914,
0.03400412201881409,
-0.023744259029626846,
-0.0014264353085309267,
0.0021278751082718372,
0.0060302880592644215,
0.005412602331489325,
0.010327914729714394,
0.04405460134148598,
0.02202730067074299,
0.0036720894277095795,
-0.016698453575372696,
0.027094418182969093,
0.00810843426734209,
-0.015389797277748585,
0.026047494262456894,
-0.003227146342396736,
0.022634517401456833,
0.010102826170623302,
0.019786881282925606,
-0.02510526031255722,
-0.0006876988336443901,
0.0037715472280979156,
0.026885032653808594,
0.013651901856064796,
-0.02678034082055092,
0.0008126755128614604,
-0.01236418355256319,
-0.0014512997586280107,
-0.014688357710838318,
-0.02535652369260788,
-0.046399716287851334,
0.0399506576359272,
0.009872502647340298,
-0.0022548146080225706,
-0.018666671589016914,
0.005035709124058485,
-0.005763322114944458,
-0.029292961582541466,
0.004433727357536554,
-0.04949861392378807,
0.029083576053380966,
0.03436007723212242,
-0.022048240527510643,
-0.02022659033536911,
0.01943092793226242,
0.003166947979480028,
-0.06884578615427017,
-0.026005616411566734,
0.030884286388754845,
-0.001866143778897822,
0.03532324731349945,
-0.040180981159210205,
0.02376519702374935,
-0.007490748073905706,
0.019734535366296768,
0.005407367367297411,
0.008019445464015007,
-0.031219303607940674,
0.014688357710838318,
-0.03944813460111618,
-0.04384521767497063,
-0.011338197626173496,
-0.016583291813731194,
-0.014646480791270733,
0.0012033093953505158,
0.03369004651904106,
0.01562012080103159,
-0.011997760273516178,
-0.0031774172093719244,
-0.02914639189839363,
0.027680696919560432,
0.019608905538916588,
0.007710602600127459,
-0.004370911978185177,
0.020823337137699127,
-0.025461215525865555,
-0.025544969365000725,
0.007653021719306707,
-0.01768256351351738,
0.08777418732643127,
0.02960703894495964,
-0.0023804455995559692,
-0.04175136983394623,
-0.019200604408979416,
0.0047190142795443535,
0.03863153234124184,
-0.030926164239645004,
-0.01898074895143509,
-0.03132399544119835,
-0.011327728629112244,
0.011076466180384159,
0.02998393215239048,
0.028287913650274277,
0.04778165742754936,
0.035511694848537445,
0.02468649111688137,
0.015819035470485687,
0.017337078228592873,
-0.002787437755614519,
-0.0013394096167758107,
-0.013348293490707874,
-0.003447000402957201,
-0.007218547631055117,
0.04300767928361893,
0.008684243075549603,
0.0043813809752464294,
-0.01931576617062092,
0.020917560905218124,
0.02644532546401024,
0.004083007574081421,
-0.015902791172266006,
-0.010652462020516396,
0.011432420462369919,
0.01322266273200512,
-0.041562922298908234,
0.0043813809752464294,
-0.009244347922503948,
0.0028947475366294384,
-0.01442662626504898,
0.01722191646695137,
0.013788001611828804,
-0.019033096730709076,
0.007621613796800375,
0.012877177447080612,
-0.0002255796134704724,
-0.026005616411566734,
-0.010416903533041477,
-0.01793382503092289,
-0.007762948516756296,
-0.03986690193414688,
-0.011369605548679829,
-0.011694151908159256,
-0.012207144871354103,
-0.011547582224011421,
-0.02615218609571457,
0.004017574712634087,
-0.0093019288033247,
-0.01684502325952053,
-0.0065537504851818085,
-0.02056160569190979,
0.02422584407031536,
0.002320247469469905,
0.019504211843013763,
0.003980932291597128,
-0.016614699736237526,
-0.017661623656749725,
-0.044263988733291626,
0.034674156457185745,
0.009076839312911034,
-0.05418883636593819,
0.028141343966126442,
-0.0042793056927621365,
0.0036537682171911,
0.0006373155629262328,
0.00928098987787962,
-0.0073075364343822,
-0.01663563773036003,
0.020195182412862778,
0.014813988469541073,
-0.008035149425268173,
0.019902043044567108,
-0.0016698453109711409,
-0.020257998257875443,
-0.04405460134148598,
-0.005009536165744066,
0.028120404109358788,
0.002295383019372821,
-0.01631109043955803,
-0.01621686853468418,
0.011411482468247414,
0.006710789166390896,
-0.0037165835965424776,
-0.020289406180381775,
-0.007459340617060661,
0.0010829130187630653,
0.0011817165650427341,
-0.02081286907196045,
-0.012584038078784943,
0.014489442110061646,
-0.002176295267418027,
0.02960703894495964,
-0.0026173123624175787,
0.031470563262701035,
0.02477024495601654,
0.004630025941878557,
-0.021734163165092468,
-0.000538512016646564,
0.010626288130879402,
-0.013693778775632381,
0.043468326330184937,
-0.02657095529139042,
-0.0525556355714798,
0.04024379700422287,
0.01078332681208849,
-0.007977568544447422,
0.004936251323670149,
0.026424385607242584,
-0.005543467588722706,
-0.010908958502113819,
-0.003504581283777952,
0.02389082871377468,
0.024204906076192856,
-0.01576668955385685,
0.0027979069855064154,
0.011223035864531994,
-0.03900842368602753,
-0.012228083796799183,
0.003957376349717379,
-0.0030544036999344826,
0.019671719521284103,
0.021074600517749786,
-0.03281062841415405,
0.0006909705116413534,
-0.005522529128938913,
0.026926910504698753,
0.04154198244214058,
0.02489587664604187,
-0.022948594763875008,
0.041646674275398254,
-0.0016934011364355683,
-0.020969906821846962,
-0.027052542194724083,
-0.002159282797947526,
-0.041772305965423584,
0.005632456392049789,
-0.036600496619939804,
-0.01672986149787903,
0.03318752348423004,
-0.008092730306088924,
0.035176679491996765,
-0.005020005162805319,
0.03281062841415405,
-0.010144703090190887,
-0.015295573510229588,
-0.002216863678768277,
-0.018750425428152084,
0.01236418355256319,
-0.012898115441203117,
0.004559358116239309,
-0.03844308480620384,
-0.01913778856396675,
0.014929150231182575,
-0.009108247235417366,
-0.0015546835493296385,
0.022676395252346992,
0.014636010862886906,
0.01793382503092289,
0.006710789166390896,
0.024079274386167526,
-0.005616752430796623,
-0.008862219750881195,
-0.06361116468906403,
0.021032722666859627,
-0.01605982892215252,
0.004745187237858772,
-0.001064591808244586,
-0.008825577795505524,
-0.045017775148153305,
-0.00015245845133904368,
0.01931576617062092,
-0.013442516326904297,
-0.0025335585232824087,
-0.009050666354596615,
0.0008970838389359415,
-0.011474297381937504,
0.02127351611852646,
0.03436007723212242,
-0.024581799283623695,
0.010751919820904732,
-0.0060616955161094666,
-0.00011262622865615413,
-0.025628723204135895,
0.011641805991530418,
-0.034967295825481415,
0.018457287922501564,
0.013819409534335136,
0.015117596834897995,
-0.022529825568199158,
0.02523089200258255,
0.0049310168251395226,
0.004486073739826679,
0.0592978298664093,
0.03683082014322281,
0.00017650501104071736,
-0.02678034082055092,
-0.030716778710484505,
0.002665732754394412,
0.03119836375117302,
0.055152006447315216,
0.02952328510582447,
0.017200976610183716,
-0.026717524975538254,
-0.022341379895806313,
-0.02485399879515171,
-0.011484767310321331,
-0.013432047329843044,
-0.03044457919895649,
0.011861659586429596,
0.011128812097012997,
-0.03151244297623634,
-0.008794169872999191,
-0.0025126198306679726,
0.006386242341250181,
0.016415784135460854,
0.018991218879818916,
-0.0020441210363060236,
-0.00624490762129426,
-0.0012327542062848806,
0.015033842995762825,
0.004949337802827358,
0.011463828384876251,
0.039217811077833176,
-0.0003916153800673783,
-0.018090862780809402,
-0.00917106308043003,
0.03969939425587654,
0.022864840924739838,
-0.0033187521621584892,
-0.01614358276128769,
-0.022425133734941483,
0.009406620636582375,
-0.011463828384876251,
0.004776595160365105,
0.01801757887005806,
0.013170315884053707,
-0.007239486090838909,
-0.027890080586075783,
0.044473372399806976,
-0.00775771401822567,
-0.013128438964486122,
-0.005543467588722706,
-0.0181850865483284,
0.00008281339978566393,
0.0015258931089192629,
-0.015149004757404327,
0.0060721649788320065,
-0.017703501507639885,
0.021126946434378624,
-0.020948968827724457,
-0.014636010862886906,
0.010908958502113819,
0.0213468000292778,
-0.017734909430146217,
0.001176481950096786,
-0.0008663304033689201,
-0.033752862364053726,
-0.05833465978503227,
0.01559918187558651,
0.006182091776281595,
-0.030507393181324005,
-0.0031774172093719244,
-0.02093849889934063,
0.0037087316159158945,
0.040851011872291565,
-0.01600748300552368,
-0.0032559367828071117,
0.07588112354278564,
0.03316658362746239,
0.016991592943668365,
0.008427745662629604,
0.005527764093130827,
0.01892840303480625,
-0.0038657705299556255,
0.019902043044567108,
-0.010626288130879402,
0.0002406291605439037,
0.04166761413216591,
-0.008909331634640694,
0.02405833639204502,
0.036768004298210144,
0.004407553933560848,
0.03077959455549717,
-0.005195365287363529,
-0.016824085265398026,
0.04954048991203308,
-0.009244347922503948,
-0.013620493933558464,
0.0009304545819759369,
-0.02001720480620861,
-0.005585344973951578,
0.006281550042331219,
0.019828759133815765,
-0.018541041761636734,
-0.0007688355399295688,
0.010772857815027237,
0.027324741706252098,
-0.030507393181324005,
0.005574875511229038,
0.019985796883702278,
0.024037398397922516,
-0.0008499721880070865,
0.02518901415169239,
-0.00471116229891777,
-0.01709628477692604,
-0.01442662626504898,
0.011662743985652924,
-0.0017876244382932782,
-0.03061208687722683,
0.007647786755114794,
-0.004959807265549898,
-0.00034875687560997903,
-0.014238179661333561,
0.014332402497529984,
-0.015117596834897995,
0.004739952739328146,
-0.0011797535698860884,
-0.022341379895806313,
-0.035386063158512115,
-0.008495796471834183,
-0.019922982901334763,
-0.015379328280687332,
-0.0046169389970600605,
0.0181850865483284,
-0.007181905210018158,
0.006192561239004135,
0.0002610769297461957,
-0.01676126942038536,
-0.009291458874940872,
-0.0043290345929563046,
-0.020676767453551292,
-0.00811366830021143,
-0.007454105652868748,
0.019336704164743423,
-0.028162281960248947,
-0.022173870354890823,
-0.01497102715075016,
-0.012186206877231598,
0.0015664615202695131,
0.022529825568199158,
-0.05841841548681259,
0.018792303279042244,
-0.006967285647988319,
-0.004059451632201672,
0.013369232416152954,
0.035804834216833115,
-0.006082633975893259,
0.010751919820904732,
-0.034339141100645065,
-0.02359768934547901,
0.021671347320079803,
0.03934343904256821,
0.0038631532806903124,
-0.022404193878173828,
-0.009322866797447205,
-0.006846889387816191,
-0.01069957297295332,
-0.0512993223965168,
-0.030130499973893166,
0.011788375675678253,
-0.020404567942023277,
0.013055154122412205,
0.0037218183279037476,
0.00813460722565651,
-0.0084068076685071,
0.01568293571472168,
-0.03775211423635483,
-0.009354274719953537,
0.0068730623461306095,
0.003541223704814911,
0.020048612728714943,
0.01876089535653591,
-0.014280056580901146,
-0.023911766707897186,
-0.004064686130732298,
0.017525523900985718,
-0.02931389957666397,
-0.0007099459762685001,
0.019943920895457268,
-0.011003181338310242,
0.00838063471019268,
0.027282865718007088,
0.00030671630520373583,
-0.043761465698480606,
0.004624790977686644,
-0.01642625220119953,
-0.020509259775280952,
0.00004559849185170606,
-0.040139105170965195,
0.02093849889934063,
0.021200230345129967,
-0.006836419925093651,
0.003025613259524107,
0.015421205200254917,
-0.02506338432431221,
0.010867081582546234,
-0.0023097782395780087,
-0.003823893377557397,
-0.00957412924617529,
-0.0044494313187897205,
-0.030507393181324005,
0.03285250440239906,
0.013610024936497211,
0.004928399343043566,
0.02619406208395958,
0.01562012080103159,
-0.007056274451315403,
0.010322680696845055,
-0.006951581686735153,
-0.006051226519048214,
0.028287913650274277,
-0.011024120263755322,
-0.0013819410232827067,
0.028350727632641792,
-0.003447000402957201,
-0.00838586874306202,
0.039804086089134216,
0.03226622939109802,
-0.007349413353949785,
-0.02703160233795643,
0.006051226519048214,
0.0014316699234768748,
-0.01459413394331932,
-0.013547209091484547,
0.1265522837638855,
-0.027785388752818108,
0.0015756221255287528,
0.010961304418742657,
-0.004535802640020847,
-0.020174244418740273,
0.03415069356560707,
-0.004229576792567968,
0.033878494054079056,
0.00028332407237030566,
0.019587965682148933,
-0.002126566367223859,
0.041939813643693924,
0.020362690091133118,
0.028078528121113777,
0.002233876148238778,
-0.0021056279074400663,
0.03199402615427971,
0.005216303747147322,
-0.003072724910452962,
0.027429433539509773,
-0.004637877456843853,
0.011474297381937504,
0.02657095529139042,
-0.020048612728714943,
-0.0020362690556794405,
-0.00411964999511838,
-0.001007665297947824,
0.008186953142285347,
-0.023555811494588852,
0.004271453712135553,
-0.0036747066769748926,
0.012646853923797607,
-0.041395414620637894,
0.0019328852649778128,
-0.03249655291438103,
-0.023723319172859192,
-0.008228830061852932,
-0.004247898235917091,
0.002239110879600048,
0.01677173748612404,
0.02573341503739357,
-0.020362690091133118,
0.009684056043624878,
0.011568521149456501,
0.016991592943668365,
-0.023220796138048172,
0.014028795063495636,
-0.008872688747942448,
-0.044096481055021286,
0.015672467648983,
0.028308851644396782,
-0.00008473548950860277,
-0.009479905478656292,
-0.033920370042324066,
0.012898115441203117,
-0.012720138765871525,
-0.0001928632118506357,
-0.0073546478524804115,
-0.027282865718007088,
-0.022152932360768318,
0.01759880967438221,
0.00526603264734149,
0.00008297698514070362,
-0.0018124888883903623
] | 2025-01-16 | 1 | 39814310 | [
"T cell persistence",
"hepatobiliary pancreatic cancers",
"adaptive cell therapy",
"hepatobiliary pancreatic malignancies",
"optimized CAR-T cells",
"CAR-T cell efficacy",
"current CAR-T therapy",
"CAR-T combination therapies",
"Innovative therapeutic strategies",
"CAR-T therapy",
"tumor heterogeneity",
"chimeric antigen receptor",
"TME",
"emerging nanoparticles",
"antigen specificity",
"CAR-T engineering",
"physical barrier",
"CAR-T) cell engineering immunotherapy",
"Various studies",
"corresponding solutions",
"the ongoing global health concern",
"biotechnologies",
"immunosuppression",
"hypoxia",
"the distinct anatomical location",
"the immunosuppressive and hypoxic TME",
"the most suitable delivery strategies",
"these cancers",
"the TME",
"This review"
] | [
"Bioengineering technology",
"Chimeric antigen receptor T (CAR-T) cell immunotherapy",
"Hepatobiliary pancreatic cancers"
] | 0 | 10.1016/j.ijbiomac.2025.139829 | [
"Gao",
"Qu",
"Li",
"Guan",
"Zhang",
"Deng",
"Wang",
"Xing"
] | [
"Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, China.",
"Department of Pharmacy, The First Hospital of China Medical University, Shenyang 110001, China.",
"Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.",
"Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110004, China.",
"Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China.",
"Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address: [email protected].",
"Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, China. Electronic address: [email protected].",
"Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address: [email protected]."
] | [
"39814310"
] | [] | 10.579252 | 3.891303 |
39813621 | 28 | Current developments in T-cell receptor therapy for Acute Myeloid Leukaemia. | T-cell receptor (TCR) therapies are a promising modality for the treatment of cancers, with significant efforts being directed towards acute myeloid leukaemia (AML), a particularly challenging disease. Chimeric antigen receptor (CAR) T-cells targeting single surface antigens have shown remarkable efficacy for B-cell lymphoblastic leukaemia, lymphomas and multiple myeloma. However, AML presents formidable obstacles to the effectiveness of CAR T-cells due to the widespread expression of heterogenous leukaemia immunophenotypes and surface antigen targets additionally present on normal myeloid cells. TCR therapies are an evolving field of cell therapies that allow targeting intracellular antigenic peptides presented via HLA molecules. The development of TCR therapy for AML is progressing rapidly through preclinical research and successful clinical trials. This review specifically explores the antigens targeted in AML, the diverse methodologies and strategies employed in TCR identification and preclinical TCR T-cell development. The review also discusses innovative molecular designs to improve functional efficacy, mitigate safety concerns and overcome HLA restriction. Specific outcomes of early clinical trials targeting important antigens WT1, PRAME and HA-1 are also highlighted. Ultimately, this review underscores why TCR therapy is poised to become an indispensable component of AML immunotherapy. | [
-0.006128888111561537,
0.024012107402086258,
0.06352154910564423,
0.044040437787771225,
-0.017478276044130325,
0.005674693733453751,
0.01777377538383007,
0.02698899619281292,
-0.0032313468400388956,
0.017193719744682312,
-0.02698899619281292,
-0.06334643810987473,
-0.04798043891787529,
0.0353943295776844,
0.0043613603338599205,
-0.04881221428513527,
0.07481621205806732,
-0.012454776093363762,
0.027601884678006172,
0.01802549697458744,
0.043799661099910736,
0.01954677514731884,
-0.019327886402606964,
0.007540721446275711,
-0.02241421863436699,
-0.018813498318195343,
-0.0035104299895465374,
0.000584501656703651,
-0.026179106906056404,
-0.02276444062590599,
0.01988605223596096,
-0.022698774933815002,
-0.02370566315948963,
-0.001015781075693667,
-0.001193628297187388,
0.037955328822135925,
0.020871052518486977,
0.005220499355345964,
-0.0125642204657197,
0.007201443426311016,
0.0251284409314394,
0.026967108249664307,
0.041763994842767715,
0.04618554934859276,
-0.05551021546125412,
0.01459988672286272,
0.018430441617965698,
-0.026507440954446793,
-0.018091164529323578,
-0.0015773678896948695,
0.014107386581599712,
0.014939164742827415,
-0.020761609077453613,
0.041435662657022476,
-0.06150776892900467,
0.04115110635757446,
-0.027820773422718048,
0.0032340828329324722,
0.030316106975078583,
-0.0014241456519812346,
-0.01489538699388504,
0.019492052495479584,
-0.005959249101579189,
-0.03631366044282913,
-0.06444088369607925,
0.007343721110373735,
-0.04036310687661171,
-0.03467199578881264,
-0.0010725554311648011,
-0.0040576523169875145,
0.005275221541523933,
-0.0379115492105484,
0.014238720759749413,
-0.007387498859316111,
0.021779442206025124,
-0.007962082512676716,
-0.04467521607875824,
0.022315720096230507,
-0.000997996423393488,
-0.0062492769211530685,
0.022118719294667244,
-0.013177108950912952,
0.011973220854997635,
-0.06273354589939117,
0.006276638247072697,
0.025194108486175537,
-0.00488943001255393,
-0.00023598955885972828,
-0.017204664647579193,
-0.008399860002100468,
-0.011491665616631508,
0.004498166032135487,
-0.03646688535809517,
0.05730510503053665,
0.015289386734366417,
0.021089941263198853,
-0.006068693473935127,
-0.03975021839141846,
0.01733599789440632,
0.05586043745279312,
0.03510977327823639,
0.019689053297042847,
-0.027120329439640045,
-0.01760960929095745,
0.04419366270303726,
-0.037364330142736435,
-0.008279470726847649,
-0.01544260885566473,
0.003253235714510083,
-0.014293442480266094,
0.06759288161993027,
0.006424387916922569,
-0.0061945547349750996,
0.043646439909935,
-0.03596343845129013,
-0.060281991958618164,
-0.02300521917641163,
0.010490248911082745,
0.0225236639380455,
0.018069274723529816,
-0.011053887195885181,
0.04476277157664299,
0.017839442938566208,
-0.036926548928022385,
0.0011607949854806066,
-0.027207884937524796,
0.10865642875432968,
-0.0343436636030674,
-0.03412477299571037,
-0.03806477412581444,
0.04968777298927307,
0.006079637911170721,
0.005225971341133118,
0.012170220725238323,
-0.06702376902103424,
-0.01658083125948906,
0.006402499042451382,
-0.009401276707649231,
-0.029068440198898315,
-0.005570721346884966,
0.0285212192684412,
-0.006364193744957447,
-0.012629887089133263,
0.010714610107243061,
-0.0249533299356699,
-0.0566922165453434,
0.00884310994297266,
0.02021438628435135,
0.006637804675847292,
0.021615274250507355,
-0.013976053334772587,
0.03300844132900238,
0.0402536615729332,
-0.004391457885503769,
-0.009510721080005169,
-0.0448722168803215,
-0.003753944067284465,
0.056823547929525375,
-0.014939164742827415,
-0.052839770913124084,
-0.01210455410182476,
0.014359109103679657,
-0.043186772614717484,
-0.0316513292491436,
0.013910386711359024,
0.01087330374866724,
-0.023377330973744392,
0.025412997230887413,
-0.04198288172483444,
0.027798885479569435,
-0.04736755043268204,
-0.06509754806756973,
-0.06203310191631317,
-0.025194108486175537,
-0.032110996544361115,
-0.03289899602532387,
0.03226421773433685,
0.01201699860394001,
-0.04653577134013176,
-0.019305996596813202,
0.011502609588205814,
0.0445219948887825,
0.01146977674216032,
-0.007354665547609329,
-0.029900217428803444,
0.012060776352882385,
-0.025150330737233162,
0.009182387962937355,
-0.05993176996707916,
0.004807346500456333,
0.0025281663984060287,
0.025872662663459778,
0.021516775712370872,
-0.018255330622196198,
0.003447499591857195,
0.010512137785553932,
0.023661885410547256,
0.027098441496491432,
-0.03545999526977539,
-0.033555664122104645,
0.05034443736076355,
-0.03184833005070686,
-0.02225005254149437,
0.00573488837108016,
-0.02149488590657711,
0.005789610557258129,
0.013231831602752209,
0.043865326792001724,
-0.006829332560300827,
0.0021902567241340876,
0.0448722168803215,
-0.03156377375125885,
0.004514582920819521,
0.017292220145463943,
-0.039728328585624695,
-0.009379387833178043,
-0.03370888531208038,
0.008996332064270973,
0.0033955133985728025,
0.015803774818778038,
0.018463274464011192,
-0.021845107898116112,
-0.0015937845455482602,
0.006873110309243202,
-0.0638279914855957,
0.023399218916893005,
0.012006053701043129,
-0.03734244033694267,
-0.0011108609614893794,
-0.020017385482788086,
-0.001015781075693667,
0.019305996596813202,
0.020794441923499107,
-0.024843886494636536,
-0.02311466448009014,
-0.019678108394145966,
-0.006774610374122858,
0.00620002718642354,
0.042442549020051956,
-0.05117621645331383,
0.021943608298897743,
0.027185996994376183,
0.03823988512158394,
-0.016022665426135063,
-0.006139832548797131,
-0.0012524547055363655,
-0.014391942881047726,
-0.06645465642213821,
0.03445310518145561,
0.010949915274977684,
0.0035350550897419453,
0.017138997092843056,
0.006331360433250666,
0.020258164033293724,
0.018857276067137718,
0.02961566299200058,
0.005045388359576464,
-0.04441254958510399,
-0.000004024006557301618,
-0.0022805482149124146,
0.010468360036611557,
0.005800554994493723,
-0.014643664471805096,
-0.03138866275548935,
-0.03003155253827572,
0.019732831045985222,
0.008629693649709225,
0.018069274723529816,
0.0575677715241909,
-0.009702248498797417,
0.023793218657374382,
0.024471774697303772,
0.021122774109244347,
-0.018003609031438828,
-0.03392777219414711,
-0.029812661930918694,
-0.0079128323122859,
0.019918886944651604,
0.01556299813091755,
0.031016550958156586,
-0.005245124455541372,
-0.003918110392987728,
0.010145498439669609,
-0.03887466341257095,
-0.0008618748979642987,
-0.01776283048093319,
-0.0015103331534191966,
-0.03232988342642784,
-0.017204664647579193,
-0.028411773964762688,
0.030272329226136208,
-0.020630275830626488,
-0.02471255324780941,
-0.03484710678458214,
-0.016438553109765053,
0.011004636995494366,
0.005012555047869682,
-0.019021442160010338,
-0.04723621532320976,
0.02987832948565483,
-0.003931791055947542,
0.016734052449464798,
-0.0023735761642456055,
-0.04889976978302002,
0.03478144109249115,
0.02604777365922928,
-0.0004541943781077862,
-0.03272388502955437,
0.029068440198898315,
0.038108550012111664,
0.03197966143488884,
-0.0061124712228775024,
0.05336510390043259,
-0.007551665883511305,
-0.0201268307864666,
-0.026179106906056404,
-0.0008864998817443848,
-0.08107643574476242,
0.011404109187424183,
-0.03259254992008209,
-0.034825216978788376,
-0.027207884937524796,
-0.028192885220050812,
0.01459988672286272,
0.011228998191654682,
-0.04069143906235695,
0.007086527068167925,
-0.026463663205504417,
0.026179106906056404,
-0.06579799205064774,
0.00922616571187973,
-0.055466435849666595,
0.06794310361146927,
-0.013571109622716904,
-0.017795665189623833,
0.0027032773941755295,
-0.00948335975408554,
-0.027295440435409546,
0.02207494154572487,
0.05796176940202713,
-0.0006009183125570416,
0.02438421919941902,
-0.023574329912662506,
0.03478144109249115,
0.0020301942713558674,
-0.013560164719820023,
0.025960218161344528,
-0.018977664411067963,
-0.014577997848391533,
0.03471577167510986,
-0.015584887005388737,
0.003666388336569071,
0.02571944147348404,
-0.012728387489914894,
-0.024143440648913383,
0.030250441282987595,
-0.03887466341257095,
-0.02241421863436699,
0.007157665677368641,
0.01563960872590542,
0.011787164956331253,
-0.0022873885463923216,
-0.047498881816864014,
0.02080538682639599,
0.05213932693004608,
0.07788065820932388,
-0.009543553926050663,
0.016110220924019814,
-0.008558554574847221,
-0.059099990874528885,
-0.017664331942796707,
0.006610443349927664,
0.05769910290837288,
-0.0204770527780056,
-0.006998971104621887,
0.036182329058647156,
0.011349387466907501,
0.0024146176874637604,
0.03891843929886818,
0.01566149853169918,
0.03992532938718796,
-0.025412997230887413,
0.010096248239278793,
-0.04038499295711517,
-0.010988220572471619,
0.01434816513210535,
-0.0011922603007405996,
-0.022315720096230507,
-0.08387821167707443,
0.04145754873752594,
-0.013275609351694584,
-0.03079766221344471,
-0.021615274250507355,
0.031344883143901825,
-0.0280834399163723,
0.060457102954387665,
-0.05213932693004608,
0.06803065538406372,
0.0643533244729042,
-0.005784138105809689,
0.0005352516891434789,
-0.02418721839785576,
-0.00410416629165411,
-0.05227065831422806,
0.021779442206025124,
-0.028149107471108437,
-0.008049638010561466,
0.027558106929063797,
0.023749440908432007,
-0.031016550958156586,
-0.016197776421904564,
0.03802099451422691,
0.04640443995594978,
0.015048609115183353,
-0.015004831366240978,
-0.02480010874569416,
-0.04951266199350357,
0.04951266199350357,
-0.030162885785102844,
0.02226099744439125,
0.01989699713885784,
-0.05743643641471863,
0.027886440977454185,
0.01078574825078249,
0.008405332453548908,
0.0041260551661252975,
0.0693877711892128,
0.024318551644682884,
-0.0062328604981303215,
-0.03817421570420265,
-0.004060388542711735,
0.037451885640621185,
0.006314943544566631,
-0.009368442930281162,
-0.010079831816256046,
0.024230996146798134,
-0.02243610844016075,
0.020684996619820595,
-0.014107386581599712,
0.011218054220080376,
-0.016208719462156296,
0.03123543970286846,
0.002039770595729351,
-0.01248760987073183,
0.017445441335439682,
0.020761609077453613,
-0.016985775902867317,
0.03572266176342964,
-0.05244576930999756,
0.0015267498092725873,
0.001255190814845264,
-0.047673992812633514,
-0.0006358037353493273,
0.006123415660113096,
-0.01700766384601593,
-0.028236662968993187,
0.04872465878725052,
-0.058093104511499405,
0.0002530902565922588,
0.04609799385070801,
0.021516775712370872,
-0.037714552134275436,
0.001580103999003768,
-0.030316106975078583,
-0.023661885410547256,
0.01665744185447693,
0.0641782134771347,
-0.019732831045985222,
0.030578773468732834,
-0.02427477389574051,
0.042179882526397705,
-0.028980884701013565,
0.001396100502461195,
0.01488444209098816,
-0.027733217924833298,
0.05432821437716484,
0.0372111052274704,
0.004446180071681738,
0.056998658925294876,
-0.012126442976295948,
-0.01146977674216032,
-0.004145207814872265,
-0.01536599826067686,
-0.014249664731323719,
-0.0016703956061974168,
-0.009549026377499104,
-0.055116213858127594,
0.008607804775238037,
-0.014468553476035595,
0.05629821494221687,
-0.00014586890756618232,
-0.019021442160010338,
0.020969552919268608,
-0.00759544363245368,
0.015683386474847794,
-0.020345719531178474,
-0.007896415889263153,
-0.011940387077629566,
-0.014501387253403664,
0.002603409346193075,
-0.022961441427469254,
-0.006139832548797131,
0.014567053876817226,
0.044215548783540726,
0.05205177143216133,
0.0638279914855957,
0.032701995223760605,
0.03500032797455788,
-0.003674596780911088,
0.047673992812633514,
-0.037692662328481674,
-0.03725488483905792,
0.0372111052274704,
-0.010107193142175674,
-0.03885277360677719,
-0.050825994461774826,
-0.06781177222728729,
-0.009543553926050663,
-0.0007059165509417653,
-0.0034693884663283825,
-0.0016006247606128454,
-0.002577416365966201,
0.0043449439108371735,
-0.01248760987073183,
0.03171699494123459,
-0.008252110332250595,
-0.024318551644682884,
0.01109219342470169,
-0.043383773416280746,
-0.03758321702480316,
0.014862553216516972,
0.00030781247187405825,
-0.0033216385636478662,
0.03324921801686287,
-0.032045330852270126,
-0.0018578191520646214,
-0.038371216505765915,
0.03712354972958565,
-0.028543107211589813,
-0.025456774979829788,
0.0031985135283321142,
-0.021363552659749985,
0.02166999690234661,
-0.005425707437098026,
0.002504909411072731,
0.012969165109097958,
-0.006271165795624256,
-0.02742677368223667,
0.028958996757864952,
-0.002046610927209258,
0.021888885647058487,
-0.03189210593700409,
0.004364096559584141,
-0.03366510570049286,
0.009964914992451668,
-0.02486577443778515,
-0.020367609336972237,
-0.0253035519272089,
-0.015935109928250313,
-0.03335866332054138,
-0.04101977124810219,
-0.015201831236481667,
-0.001976839965209365,
-0.016132108867168427,
-0.010304193012416363,
0.032614439725875854,
-0.006216443609446287,
-0.01945921964943409,
-0.017215609550476074,
0.036007218062877655,
0.008339665830135345,
0.000148434002767317,
-0.0013872081181034446,
-0.019108997657895088,
0.011190692894160748,
-0.0022340344730764627,
-0.0007264374289661646,
0.02105710841715336,
0.0008680311148054898,
0.034146662801504135,
-0.033030327409505844,
-0.009899248369038105,
-0.026113441213965416,
0.04425932839512825,
0.004727999214082956,
0.0058388602919876575,
-0.05135132744908333,
-0.008361554704606533,
-0.012509498745203018,
-0.0047006383538246155,
0.06115754693746567,
-0.00820286013185978,
0.02267688512802124,
0.0160007756203413,
-0.05349643900990486,
0.01536599826067686,
-0.013133331201970577,
-0.017029553651809692,
-0.013735275715589523,
-0.0011963644064962864,
0.014501387253403664,
0.013166164979338646,
-0.02320221997797489,
-0.02412155270576477,
-0.02453744038939476,
0.024821996688842773,
-0.013603942468762398,
-0.014271553605794907,
0.014501387253403664,
0.013680553995072842,
0.05218310281634331,
0.038546327501535416,
-0.04075710475444794,
0.01049572043120861,
0.03992532938718796,
0.027558106929063797,
0.006068693473935127,
-0.007666582241654396,
0.011590165086090565,
-0.005970193538814783,
-0.026704441756010056,
0.004156152252107859,
-0.007989443838596344,
-0.013275609351694584,
0.00474167987704277,
-0.05629821494221687,
-0.012203053571283817,
0.024427996948361397,
-0.01209360919892788,
0.01303483173251152,
-0.020258164033293724,
-0.028499329462647438,
-0.017368830740451813,
0.028149107471108437,
-0.003447499591857195,
-0.018890108913183212,
0.03206721693277359,
-0.041851550340652466,
0.013866608962416649,
0.0037402634043246508,
-0.010189276188611984,
0.030600663274526596,
-0.00239956914447248,
-0.01312238723039627,
0.009193331934511662,
-0.022742552682757378,
-0.0071303048171103,
0.011228998191654682,
0.01210455410182476,
-0.03154188394546509,
0.00009405380842508748,
-0.015311275608837605,
0.04066954925656319,
-0.012049831449985504,
0.011031998321413994,
0.008968970738351345,
0.008826693519949913,
-0.004437971860170364,
0.06684865802526474,
0.06838087737560272,
-0.0201268307864666,
0.021221274510025978,
-0.018430441617965698,
0.01777377538383007,
-0.01708427630364895,
-0.005707527045160532,
0.03222044184803963,
-0.0075188325718045235,
-0.004993401933461428,
0.004862068686634302,
0.0572175495326519,
0.03029421903192997,
0.009116721339523792,
0.0015650553395971656,
-0.0037703607231378555,
0.030753884464502335,
0.007781499065458775,
0.009997748769819736,
-0.04780532792210579,
0.01044647116214037,
0.005494110286235809,
-0.009466943331062794,
-0.0409541055560112,
-0.06930021196603775,
-0.0173469427973032,
0.013625831343233585,
0.030140995979309082,
0.006971610244363546,
0.017981719225645065,
0.0035377913154661655,
0.012378165498375893,
0.009866415522992611,
-0.021768497303128242,
-0.003931791055947542,
0.03097277320921421,
0.013439776375889778,
-0.008066054433584213,
-0.020236274227499962,
-0.024165330454707146,
-0.023486774414777756,
0.046579550951719284,
0.01583660952746868,
0.026332329958677292,
-0.010928026400506496,
0.02403399720788002,
0.0024939649738371372,
0.012761220335960388,
-0.026091551408171654,
0.023990219458937645,
0.030819552019238472,
0.0007086526602506638,
-0.003343527438119054,
-0.019590552896261215,
0.0025459511671215296,
-0.01319899782538414,
0.007316360250115395,
-0.011984164826571941,
0.0509573258459568,
-0.009237109683454037,
0.01777377538383007,
0.013089553453028202,
0.030841439962387085,
-0.02937488444149494,
0.0007476422470062971,
0.04351510480046272,
0.030491217970848083,
-0.02285199612379074,
0.07030709832906723,
-0.000496604130603373,
0.01184188760817051,
-0.024843886494636536,
-0.0068238601088523865,
-0.027601884678006172,
-0.009144081734120846,
-0.018375718966126442,
0.01828816346824169,
-0.000022124020688352175,
-0.012071720324456692,
-0.007305415812879801,
0.0011053887428715825,
0.045485105365514755,
-0.030994663015007973,
-0.037867773324251175,
0.03966266289353371,
-0.03259254992008209,
0.019929829984903336,
0.025325441733002663,
0.013516386970877647,
-0.0012887081829831004,
0.002908485708758235,
-0.008569498546421528,
0.005855277180671692,
0.00729994336143136,
-0.024471774697303772,
0.014556108973920345,
-0.021013330668210983,
-0.01277216523885727,
-0.015168998390436172,
-0.038283661007881165,
-0.022315720096230507,
-0.012213998474180698,
0.012586109340190887,
-0.004060388542711735,
-0.0010137290228158236,
-0.012301553972065449,
0.025675663724541664,
0.016132108867168427,
0.025500552728772163,
0.015869442373514175,
0.024843886494636536,
-0.01674499735236168,
0.0006115207797847688,
0.02258932963013649,
-0.03427799418568611,
-0.00427380483597517,
-0.0010581908281892538,
-0.011415054090321064,
0.030863329768180847,
-0.005409291014075279,
-0.012826886959373951,
-0.0028865968342870474,
-0.009696776047348976,
-0.028718218207359314,
0.0028154579922556877,
0.012389109469950199,
0.001886548358015716,
-0.018890108913183212,
0.012881609611213207,
-0.022228164598345757,
-0.00566922128200531,
-0.012049831449985504,
0.034978438168764114,
-0.03145432844758034,
0.01945921964943409,
-0.004437971860170364,
0.023486774414777756,
0.023486774414777756,
-0.054021771997213364,
-0.030272329226136208,
-0.020039275288581848,
-0.0027087496127933264,
-0.00031260066316463053,
0.002338006626814604,
-0.04128243774175644,
-0.00143235397990793,
-0.0008420380763709545,
-0.013067664578557014,
0.018901053816080093,
0.000163824632181786,
0.024997107684612274,
0.00791830476373434,
-0.008312304504215717,
-0.01844138652086258,
-0.013811887241899967,
-0.05949399247765541,
0.0037375271786004305,
0.05476599186658859,
0.003685541218146682,
0.008076999336481094,
0.011524498462677002,
0.0577428825199604,
-0.022983331233263016,
-0.001224409556016326,
-0.012257776223123074,
-0.005680165719240904,
-0.03121355175971985,
0.005524207837879658,
0.010386276058852673,
0.027448663488030434,
-0.014567053876817226,
0.047104883939027786,
-0.0008728193351998925,
-0.01676688715815544,
0.016208719462156296,
-0.004752624314278364,
-0.001083499868400395,
-0.012279665097594261,
0.008323248475790024,
0.03366510570049286,
0.04231121763586998,
0.024778218939900398,
-0.007748665753751993,
-0.023048996925354004,
-0.038962218910455704,
0.011272775940597057,
0.008224749006330967,
-0.023333553224802017,
0.016219664365053177,
-0.01710616424679756,
-0.03370888531208038,
0.03121355175971985,
-0.007086527068167925,
-0.02902466244995594,
-0.009122192859649658,
0.030753884464502335,
0.03926866129040718,
0.00922069326043129,
-0.03449688479304314,
0.04605421796441078,
0.026704441756010056,
-0.01219210959970951,
0.0015158053720369935,
-0.017631497234106064,
-0.04579154774546623,
0.05988799035549164,
-0.03975021839141846,
0.014227775856852531,
0.0031629439909011126,
-0.004807346500456333,
-0.04579154774546623,
0.01938260905444622,
0.025106552988290787,
-0.016361942514777184,
-0.020860107615590096,
-0.011294664815068245,
-0.009828110225498676,
0.0019057011231780052,
-0.015453553758561611,
-0.016394775360822678,
-0.023486774414777756,
-0.005217763129621744,
-0.03552566096186638,
-0.032614439725875854,
0.003338055219501257,
-0.0037265827413648367,
0.01146977674216032,
-0.008328720927238464,
-0.0189557746052742,
-0.005866221617907286,
0.012837831862270832,
0.011316553689539433,
-0.008334193378686905,
-0.0041971937753260136,
-0.01294727623462677,
0.01125088706612587,
-0.004279277287423611,
-0.003967360593378544,
0.050213105976581573,
-0.03517543897032738,
0.0218232199549675,
-0.0286963302642107,
0.0023489510640501976,
-0.02223910763859749,
0.019273163750767708,
-0.025850774720311165,
0.008722720667719841,
0.010632526129484177,
0.022720662876963615,
-0.001249034539796412,
0.015431664884090424,
-0.023377330973744392,
-0.0022408748045563698,
-0.0021875204984098673,
0.007223332300782204,
0.006386082619428635,
0.0014556109672412276,
0.010900665074586868,
0.04881221428513527,
0.04314299300312996,
-0.003154735779389739,
-0.029900217428803444,
-0.013811887241899967,
0.012837831862270832,
0.01777377538383007,
0.013264665380120277,
0.021615274250507355,
-0.006851221434772015,
0.04340565949678421,
0.00875555444508791,
-0.004063124302774668,
-0.01879160851240158,
0.0027155899442732334,
0.009499776177108288,
0.008159082382917404,
0.03944377228617668,
0.009116721339523792,
0.01581471972167492,
-0.013636776246130466,
0.011491665616631508,
0.006210971623659134,
-0.0030835967045277357,
0.050388216972351074,
-0.03353377431631088,
-0.05459088087081909,
0.02556621842086315,
-0.009034637361764908,
-0.014151165261864662,
-0.018583664670586586,
0.02987832948565483,
0.04447821527719498,
0.051657769829034805,
-0.0016731317155063152,
0.010928026400506496,
0.002853763522580266,
-0.025697551667690277,
-0.02867444045841694,
0.029681328684091568,
-0.03121355175971985,
0.006446276791393757,
-0.04003477096557617,
-0.019065219908952713,
0.002700541401281953,
-0.0024720760993659496,
0.005751304794102907,
0.010720081627368927,
0.02438421919941902,
0.010550443083047867,
0.03751755133271217,
-0.04482843726873398,
0.05572910234332085,
-0.01607738621532917,
-0.03775832802057266,
0.007064638193696737,
0.018091164529323578,
0.007693943567574024,
0.005277957767248154,
0.037626996636390686,
-0.032877106219530106,
0.015781886875629425,
0.024252885952591896,
0.037451885640621185,
-0.001513069262728095,
-0.03933432698249817,
-0.008405332453548908,
-0.05051954835653305,
0.0003526162763591856,
0.004320318810641766,
-0.007973026484251022,
-0.0406038835644722,
0.009357498958706856,
0.055378880351781845,
0.02707655169069767,
-0.026179106906056404,
-0.03114788420498371,
0.04441254958510399,
-0.0321766622364521,
-0.027864551171660423,
-0.03944377228617668,
0.03758321702480316,
0.04509110376238823,
-0.017894163727760315,
-0.015508275479078293,
0.011218054220080376,
0.005970193538814783,
-0.02114466391503811,
-0.02040044218301773,
0.051657769829034805,
-0.02766755223274231,
0.05896865949034691,
-0.03443121910095215,
0.0316513292491436,
0.03570077195763588,
0.0019070692360401154,
-0.004347680136561394,
-0.002908485708758235,
-0.025281663984060287,
-0.013735275715589523,
-0.05187666043639183,
-0.050388216972351074,
0.0005164408939890563,
-0.01349449809640646,
0.027054663747549057,
0.0004097325727343559,
0.041939105838537216,
0.006544776726514101,
0.006085110362619162,
0.005494110286235809,
-0.018255330622196198,
0.03581021726131439,
0.020498942583799362,
0.01023305393755436,
0.006123415660113096,
0.008640637621283531,
0.0006898419233039021,
-0.02233760803937912,
0.000845458242110908,
-0.010424582287669182,
0.06194554641842842,
0.035416219383478165,
-0.001922117779031396,
-0.0060030268505215645,
-0.01606644317507744,
0.015891332179307938,
0.04509110376238823,
-0.02140733040869236,
-0.014380997978150845,
-0.022895773872733116,
-0.0254786629229784,
0.008317776955664158,
0.0311259962618351,
0.04583532735705376,
0.03764888271689415,
0.007688471116125584,
0.014643664471805096,
0.02300521917641163,
0.036838993430137634,
0.011622998863458633,
0.014151165261864662,
-0.007081054616719484,
-0.000857086677569896,
0.004254652187228203,
0.0007127568242140114,
-0.0015705275582149625,
0.0008953922661021352,
-0.022742552682757378,
0.009237109683454037,
0.02740488573908806,
0.012695553712546825,
0.010588748380541801,
-0.014796886593103409,
-0.0019741039723157883,
-0.002276444109156728,
-0.01904333010315895,
0.011360331438481808,
-0.03046933002769947,
0.0031246384605765343,
-0.011146915145218372,
-0.004752624314278364,
-0.013800942339003086,
-0.04259577393531799,
-0.003778568934649229,
0.037692662328481674,
0.01044647116214037,
-0.024690663442015648,
-0.0023065414279699326,
-0.0034584440290927887,
-0.018649330362677574,
-0.01192944310605526,
0.01497199758887291,
-0.016558941453695297,
-0.01192944310605526,
-0.01710616424679756,
-0.04224554821848869,
-0.012082665227353573,
-0.027798885479569435,
-0.008334193378686905,
-0.005756777245551348,
0.015344109386205673,
0.04036310687661171,
0.001047930447384715,
-0.00239956914447248,
-0.0002289782714797184,
-0.015464497730135918,
-0.03502221778035164,
-0.05498488247394562,
0.05607932433485985,
-0.005975665990263224,
-0.04736755043268204,
0.02935299649834633,
0.011272775940597057,
-0.010752915404736996,
0.010145498439669609,
-0.0036910134367644787,
-0.01417305413633585,
0.00479913828894496,
0.009746026247739792,
0.0187806636095047,
-0.02801777422428131,
0.017565831542015076,
0.010200221091508865,
0.005171249154955149,
-0.024165330454707146,
0.004744416102766991,
0.002052083145827055,
-0.00651194341480732,
-0.02471255324780941,
-0.029659440740942955,
0.009007276967167854,
-0.008219276554882526,
0.013385053724050522,
0.007387498859316111,
0.02453744038939476,
0.018769720569252968,
-0.004665068816393614,
-0.01333033200353384,
-0.010802165605127811,
-0.02506277523934841,
-0.00905105471611023,
-0.009614693000912666,
-0.006555721163749695,
0.02793021872639656,
0.018211552873253822,
-0.00604680459946394,
0.005778666120022535,
-0.029922107234597206,
-0.016449498012661934,
-0.03167321905493736,
0.043536994606256485,
-0.026682551950216293,
-0.02952810749411583,
0.02893710695207119,
0.025500552728772163,
0.0017169094644486904,
-0.01145883183926344,
0.004610346630215645,
-0.015475442633032799,
-0.006780082359910011,
-0.00783074926584959,
0.02080538682639599,
0.04010044038295746,
-0.0254786629229784,
-0.018331941217184067,
0.008230221457779408,
-0.016952943056821823,
-0.019864164292812347,
0.0026006733532994986,
0.014129276387393475,
0.011524498462677002,
0.011612053960561752,
-0.029593773186206818,
0.0029467912390828133,
0.004268332850188017,
0.0071631381288170815,
0.0565171055495739,
0.04239877313375473,
-0.014402886852622032,
0.021024275571107864,
-0.011371276341378689,
0.008509304374456406,
-0.015223720110952854,
-0.021122774109244347,
-0.011885665357112885,
-0.01743449829518795,
-0.024165330454707146,
-0.034321773797273636,
0.019951719790697098,
0.0007921040523797274,
-0.006375138182193041,
-0.007666582241654396,
0.013483554124832153,
-0.0064681656658649445,
-0.04316488280892372,
0.00939033180475235,
-0.011349387466907501,
0.0026526593137532473,
-0.02497521974146366,
0.03226421773433685,
-0.04202666133642197,
-0.02615721896290779,
-0.003715638304129243,
-0.00729994336143136,
0.009789803996682167,
0.040581993758678436,
0.008273999206721783,
0.018145887181162834,
0.028061551973223686,
0.005286165978759527,
-0.007513360120356083,
-0.00404123542830348,
-0.05222688242793083,
-0.004979721736162901,
-0.01718277484178543,
0.005173985380679369,
-0.011152387596666813,
-0.017839442938566208,
-0.035656996071338654,
-0.0016361941816285253,
-0.01096085924655199,
-0.02090388536453247,
-0.016963886097073555,
0.006183610297739506,
0.012717442587018013,
-0.0014966526068747044,
0.00910030398517847,
0.016197776421904564,
-0.016952943056821823,
0.007382026873528957,
0.00837797112762928,
0.006572138052433729,
0.0036828049924224615,
0.007989443838596344,
-0.029571885243058205,
0.004366832785308361,
0.003466652240604162,
0.008301359601318836,
0.0031629439909011126,
0.024603107944130898,
0.005975665990263224,
0.023486774414777756,
0.05761154741048813,
0.018813498318195343,
0.022830108180642128,
-0.019316941499710083,
-0.03613854944705963,
-0.015716219320893288,
0.042858440428972244,
0.015541109256446362,
0.046842217445373535,
0.01108124852180481,
-0.02976888418197632,
-0.014019831083714962,
-0.01498294249176979,
-0.025916440412402153,
-0.033883996307849884,
-0.036510661244392395,
0.012728387489914894,
0.017040498554706573,
-0.020881997421383858,
-0.022457996383309364,
0.015147109515964985,
0.005680165719240904,
0.013527331873774529,
-0.0003734791243914515,
-0.01488444209098816,
-0.02232666313648224,
-0.016887275502085686,
0.0035897772759199142,
0.0088485823944211,
0.01087330374866724,
0.013231831602752209,
0.012553276494145393,
0.0023968329187482595,
-0.029046552255749702,
0.04220177233219147,
0.02055366337299347,
-0.01219210959970951,
-0.023924551904201508,
-0.03898410499095917,
0.007272582501173019,
0.013264665380120277,
-0.020422330126166344,
0.024406107142567635,
0.008109832182526588,
-0.007617332506924868,
-0.02267688512802124,
0.04034121707081795,
0.009663943201303482,
0.006210971623659134,
-0.006544776726514101,
-0.012794054113328457,
-0.009384860284626484,
-0.00028780463617295027,
0.009828110225498676,
-0.002670444082468748,
-0.017872275784611702,
0.0017483747797086835,
0.008186443708837032,
-0.025434885174036026,
-0.0034693884663283825,
0.00004548784272628836,
-0.046667106449604034,
0.009647526778280735,
-0.0021998330485075712,
-0.03184833005070686,
-0.05905621498823166,
-0.0024843886494636536,
0.02615721896290779,
-0.0037949855905026197,
-0.0023243261966854334,
-0.03394966199994087,
0.014643664471805096,
0.031782664358615875,
-0.013472609221935272,
0.006019443739205599,
0.03797721862792969,
0.011305609717965126,
-0.01869310811161995,
0.00846005417406559,
0.024559330195188522,
0.03292088583111763,
-0.01870405301451683,
-0.04390910640358925,
-0.031104106456041336,
-0.018561774864792824,
0.020104940980672836,
-0.0008434061310254037,
0.04495977237820625,
0.037867773324251175,
-0.020838219672441483,
0.03419043868780136,
0.010019637644290924,
-0.020236274227499962,
0.030075330287218094,
0.002607513451948762,
0.002082180231809616,
-0.016876330599188805,
0.0201268307864666,
-0.02488766424357891,
0.01955772005021572,
0.02056460827589035,
-0.012334386818110943,
0.0002578784478828311,
-0.018255330622196198,
0.018091164529323578,
-0.0058388602919876575,
-0.00039331591688096523,
0.004260124638676643,
0.04968777298927307,
0.014238720759749413,
-0.0027935691177845,
0.014205886982381344,
-0.021111831068992615,
-0.02394644170999527,
-0.008487415499985218,
0.011907554231584072,
-0.029134107753634453,
0.02302710898220539,
0.010211165063083172,
-0.009034637361764908,
0.003209457965567708,
0.0006833436782471836,
0.0018660274799913168,
-0.005247860215604305,
-0.011754332110285759,
-0.00419172178953886,
-0.03005344048142433,
0.006490054540336132,
-0.005844332743436098,
-0.02817099541425705,
-0.008109832182526588,
-0.015300331637263298,
-0.020444219931960106,
0.006117943674325943,
-0.01894483156502247,
0.013888497836887836,
0.0061945547349750996,
-0.011830942705273628,
-0.01294727623462677,
0.01378999836742878,
-0.02563188597559929,
0.02613532915711403,
-0.00829041562974453,
-0.006725360173732042,
-0.01700766384601593,
-0.0036937494296580553,
-0.019601497799158096,
0.024252885952591896,
-0.04220177233219147,
0.004208138212561607,
-0.006763665936887264,
-0.010862359777092934,
0.012115498073399067,
0.026091551408171654,
-0.005882638040930033,
-0.004790930077433586,
-0.024340441450476646,
0.0035843050573021173,
0.03259254992008209,
0.02192171849310398,
0.00651741586625576,
-0.04349321499466896,
-0.006791026797145605,
-0.011228998191654682,
-0.020345719531178474,
-0.01311144232749939,
-0.014238720759749413,
0.006741777062416077,
0.006074165925383568,
0.007064638193696737,
-0.028411773964762688,
0.027361107990145683,
-0.0039345272816717625,
0.03830555081367493,
-0.05069465935230255,
0.002444715006276965,
0.0049332077614963055,
-0.005827915854752064,
0.01324277650564909,
0.036335550248622894,
-0.034650105983018875,
-0.003877068869769573,
-0.027601884678006172,
0.018386663869023323,
-0.02961566299200058,
-0.00009901300654746592,
0.0035049577709287405,
0.004320318810641766,
-0.030184773728251457,
0.03530677407979965,
0.013144276104867458,
-0.027382995933294296,
-0.01378999836742878,
-0.022217219695448875,
-0.010019637644290924,
0.0026444511022418737,
-0.039815884083509445,
0.01802549697458744,
0.04086655005812645,
0.02173566445708275,
-0.006703471299260855,
0.031344883143901825,
-0.0409541055560112,
0.01919655315577984,
-0.008569498546421528,
-0.02090388536453247,
-0.00526427710428834,
0.009532609954476357,
-0.023421108722686768,
-0.0033955133985728025,
0.009176915511488914,
0.013833776116371155,
0.029987774789333344,
0.02539110742509365,
0.005067277234047651,
0.029549995437264442,
-0.008711776696145535,
-0.020783497020602226,
0.03478144109249115,
-0.004462596494704485,
0.005247860215604305,
0.020083053037524223,
0.025522440671920776,
-0.002235402585938573,
0.01472027599811554,
0.0061945547349750996,
-0.019054275006055832,
0.008153609931468964,
-0.01676688715815544,
-0.002089020563289523,
-0.050913549959659576,
-0.00011457463551778346,
0.089744433760643,
-0.0025295342784374952,
-0.0011190692894160748,
0.03471577167510986,
-0.02131977491080761,
-0.016197776421904564,
0.025916440412402153,
0.008005860261619091,
0.02521599642932415,
-0.01172149833291769,
0.005026235245168209,
0.019437331706285477,
0.027711329981684685,
0.0206521637737751,
0.0339934416115284,
-0.014709331095218658,
0.0025938330218195915,
0.04727999493479729,
-0.014665553346276283,
0.007195971440523863,
0.02742677368223667,
0.037189219146966934,
-0.0062875826843082905,
0.021089941263198853,
-0.021046163514256477,
0.013428831472992897,
0.0060577490366995335,
0.0003098645538557321,
0.013768109492957592,
-0.003893485525622964,
0.02116655372083187,
0.003075388493016362,
-0.00948335975408554,
-0.02157149650156498,
0.0006816335953772068,
-0.019010497257113457,
-0.01851799711585045,
-0.021472997963428497,
0.014556108973920345,
0.014162109233438969,
-0.003773096716031432,
0.014238720759749413,
0.003838763339444995,
0.008651582524180412,
0.011940387077629566,
0.007141249254345894,
-0.03274577483534813,
0.016372887417674065,
0.010254942812025547,
-0.021352607756853104,
0.015125220641493797,
-0.027798885479569435,
-0.007086527068167925,
-0.02403399720788002,
-0.032964661717414856,
-0.013133331201970577,
-0.011059359647333622,
-0.011207109317183495,
0.012410998344421387,
-0.03167321905493736,
-0.01184188760817051,
0.009461470879614353,
0.024143440648913383,
-0.01665744185447693,
0.004377777222543955
] | 2025-01-15 | 1 | 39813621 | [
"cell therapies",
"TCR therapy",
"single surface antigens",
"normal myeloid cells",
"important antigens WT1",
"antigen targets",
"Chimeric antigen receptor",
"AML immunotherapy",
"acute myeloid leukaemia",
"AML",
"heterogenous leukaemia immunophenotypes",
"TCR therapies",
"TCR identification",
"TCR",
"early clinical trials",
"successful clinical trials",
"preclinical TCR T-cell development",
"functional efficacy",
"remarkable efficacy",
"innovative molecular designs",
"B-cell lymphoblastic leukaemia",
"preclinical research",
"intracellular antigenic peptides",
"safety concerns",
"CAR T-cells",
"HLA restriction",
"significant efforts",
"HLA molecules",
"surface",
"T-cell receptor"
] | [] | 0 | 10.1182/bloodadvances.2024014105 | [
"Gore",
"Blyth",
"Bleakley",
"Lee",
"Micklethwaite",
"Gowrishankar"
] | [
"The University of Sydney, Australia.",
"The University of Sydney, Australia.",
"Fred Hutchinson Cancer Center, Seattle, Washington, United States.",
"Westmead Institute for Medical Research, Australia.",
"Westmead Hospital, Sydney, Australia.",
"The University of Sydney, Sydney, Australia."
] | [
"39813621"
] | [] | 6.819335 | 7.123146 |
39811687 | 29 | Increased functional potency of multi-edited CAR-T cells manufactured by a non-viral transfection system. | Chimeric antigen receptor (CAR)-T cell therapy represents a breakthrough for the treatment of hematological malignancies. However, to treat solid tumors and certain hematologic cancers, next-generation CAR-T cells require further genetic modifications to overcome some of the current limitations. Improving manufacturing processes to preserve cell health and function of edited T cells is equally critical. Here, we report that Solupore, a Good Manufacturing Practice-aligned, non-viral physicochemical transfection system, can be used to manufacture multi-edited CAR-T cells using CRISPR-Cas9 ribonucleoproteins while maintaining robust cell functionality. When compared to electroporation, an industry standard, T cells that were triple edited using Solupore had reduced levels of apoptosis and maintained similar proportions of stem cell memory T cells with higher oxidative phosphorylation levels. Following lentiviral transduction with a CD19 CAR, and subsequent cryopreservation, triple-edited CAR-T cells manufactured using Solupore demonstrated improved immunological synapse strength to target CD19 | [
0.03141925856471062,
0.012649000622332096,
0.014370604418218136,
0.05116987228393555,
-0.021890662610530853,
-0.028836853802204132,
-0.014059758745133877,
0.032160501927137375,
0.017084520310163498,
-0.04691368713974953,
0.027521738782525063,
0.0010222018463537097,
-0.028310807421803474,
0.000987082370556891,
0.011871888302266598,
-0.060208287090063095,
0.03615366667509079,
-0.01468144915997982,
0.01076599769294262,
0.002642182633280754,
0.045311637222766876,
0.021830884739756584,
0.03263872489333153,
-0.000569010793697089,
-0.010999131016433239,
0.0009220739011652768,
0.04557466134428978,
0.02319382131099701,
-0.036321043968200684,
-0.03141925856471062,
0.016941053792834282,
-0.024305690079927444,
0.012302289716899395,
-0.015972651541233063,
-0.002184881828725338,
0.05537823587656021,
0.03118014708161354,
-0.005523476749658585,
-0.012840290553867817,
-0.024748045951128006,
0.04791795462369919,
-0.008667794056236744,
0.008757460862398148,
0.04466603696346283,
-0.02936289831995964,
0.034288596361875534,
-0.01602047309279442,
-0.03990771621465683,
0.020611416548490524,
0.005149865057319403,
-0.022679731249809265,
0.021388528868556023,
-0.03268655017018318,
0.02137657254934311,
-0.039549048990011215,
0.0007591791800223291,
-0.036010198295116425,
0.011303998529911041,
-0.03811438009142876,
0.012923979200422764,
0.04748755320906639,
-0.03328432887792587,
0.029243342578411102,
-0.06656865775585175,
-0.03048672340810299,
0.023588353767991066,
-0.07020314782857895,
-0.005284365266561508,
0.004746364429593086,
0.038210026919841766,
0.001111121498979628,
-0.028621653094887733,
0.007687436416745186,
-0.030414989218115807,
0.027067428454756737,
0.00663534551858902,
0.0133663360029459,
0.03409730643033981,
0.0307975672185421,
-0.0097975954413414,
0.017849678173661232,
-0.010849686339497566,
0.03271045908331871,
-0.0428248792886734,
-0.02510671317577362,
-0.0038048624992370605,
0.024628490209579468,
-0.0134739363566041,
-0.04110327735543251,
-0.02232106402516365,
-0.039142560213804245,
0.012015355750918388,
-0.019487591460347176,
0.05518694594502449,
0.00044908138806931674,
-0.0247002225369215,
-0.00045281750499270856,
-0.030247611925005913,
0.02725871652364731,
0.02053968235850334,
0.03959687426686287,
-0.005356098525226116,
-0.028836853802204132,
-0.021579816937446594,
0.01562594063580036,
-0.016630208119750023,
-0.02520235814154148,
-0.03756442293524742,
0.03139534592628479,
0.004537141881883144,
0.07216386497020721,
-0.06317327171564102,
-0.009151994250714779,
0.08431073278188705,
-0.011238242499530315,
-0.06905541568994522,
-0.016163941472768784,
-0.0032847949769347906,
0.0092356838285923,
0.027999961748719215,
-0.017108431085944176,
0.004100763238966465,
0.05035689100623131,
-0.01646283082664013,
-0.006575567647814751,
-0.02773693948984146,
0.09684018045663834,
-0.03146708011627197,
-0.006479923147708178,
-0.05762588232755661,
0.0080461036413908,
-0.0007386305369436741,
0.02522626891732216,
-0.018172478303313255,
-0.04892222210764885,
0.023719865828752518,
-0.031658370047807693,
0.00011264396016485989,
0.0001415988663211465,
-0.043303102254867554,
0.01655847579240799,
-0.01202133297920227,
-0.01043721940368414,
0.0008331543067470193,
-0.04583768546581268,
-0.057386770844459534,
-0.019678881391882896,
0.014801004901528358,
-0.024329600855708122,
0.06872066110372543,
-0.021986307576298714,
0.03708619996905327,
0.03421686217188835,
0.024963246658444405,
-0.006988035049289465,
-0.036201488226652145,
0.0077771032229065895,
0.036894913762807846,
-0.01032961905002594,
-0.028430363163352013,
-0.010473085567355156,
0.032973483204841614,
-0.010574708692729473,
-0.05360880866646767,
0.009504684247076511,
-0.056143391877412796,
0.03663188964128494,
0.020025592297315598,
-0.05662161484360695,
-0.019774524495005608,
-0.016976920887827873,
-0.047224532812833786,
-0.05365663021802902,
-0.010335597209632397,
-0.04201189801096916,
-0.014992293901741505,
-0.012637045234441757,
0.022046085447072983,
-0.05719548463821411,
-0.0012082605389878154,
0.02079075016081333,
0.015578117221593857,
0.006378300487995148,
-0.0024075545370578766,
-0.014466248452663422,
0.01330655813217163,
-0.024245912209153175,
0.018614834174513817,
-0.009104172699153423,
-0.015554206445813179,
-0.02128092758357525,
-0.00956446211785078,
0.04588550701737404,
0.011561043560504913,
0.01909305714070797,
0.000001129591964854626,
0.050691649317741394,
0.01580527424812317,
0.011513221077620983,
-0.05690854787826538,
0.019523458555340767,
-0.009337306022644043,
-0.029793299734592438,
-0.009151994250714779,
-0.014753182418644428,
-0.016678031533956528,
-0.027163071557879448,
0.03294957056641579,
-0.032447438687086105,
-0.01012637373059988,
0.0530349425971508,
0.03139534592628479,
-0.028430363163352013,
0.019702792167663574,
-0.023241642862558365,
-0.010030729696154594,
0.0025674602948129177,
0.07254644483327866,
-0.0041665188036859035,
0.04626808688044548,
-0.02754565142095089,
-0.039142560213804245,
-0.0031293723732233047,
0.023062309250235558,
0.011196398176252842,
0.008177614770829678,
0.00782492570579052,
-0.039142560213804245,
0.011596910655498505,
-0.02635009214282036,
0.007370613515377045,
0.01174037717282772,
-0.014753182418644428,
-0.03708619996905327,
-0.04404434934258461,
-0.020240793004631996,
0.040266383439302444,
0.008404770866036415,
0.06016046553850174,
-0.01483687199652195,
-0.01912892423570156,
0.012708778493106365,
0.024532845243811607,
-0.003954307176172733,
0.027665207162499428,
0.0007995292544364929,
-0.011680599302053452,
-0.058677975088357925,
0.03440815210342407,
-0.015267272479832172,
0.01142355427145958,
-0.003819806966930628,
0.011632776819169521,
-0.024078533053398132,
0.02360031008720398,
0.016474785283207893,
0.01032961905002594,
-0.014215181581676006,
0.007466258015483618,
-0.0464593730866909,
-0.037373136729002,
-0.02713916078209877,
-0.03409730643033981,
-0.05030906945466995,
-0.022679731249809265,
0.030630189925432205,
0.012146866880357265,
0.025991424918174744,
0.02319382131099701,
-0.02160372957587242,
0.024628490209579468,
0.024018755182623863,
0.008697682991623878,
-0.00881126057356596,
-0.06599479168653488,
0.01718016527593136,
-0.006121255923062563,
0.020133191719651222,
-0.0067489235661923885,
0.04968738183379173,
-0.03414512798190117,
0.02388724312186241,
-0.0013098829658702016,
-0.005012375768274069,
-0.030462810769677162,
-0.0063842786476016045,
0.018770257011055946,
0.020133191719651222,
0.04485732689499855,
-0.02560884691774845,
0.0046686530113220215,
-0.004214341286569834,
-0.010885553434491158,
0.0007139721419662237,
0.003084538970142603,
-0.003053155727684498,
0.0023238654248416424,
-0.009492728859186172,
-0.03070192225277424,
0.0016050363192334771,
-0.0037540514022111893,
0.004773264285176992,
0.0024628490209579468,
-0.0265174712985754,
-0.009606306441128254,
0.0093432841822505,
-0.04798968881368637,
-0.03008023276925087,
0.03971643000841141,
0.016140028834342957,
-0.006671212147921324,
0.01235011126846075,
0.016582386568188667,
-0.00383774028159678,
0.0021355650387704372,
0.02056359313428402,
0.009761729277670383,
-0.05882143974304199,
0.012326200492680073,
-0.040768519043922424,
-0.037110112607479095,
0.002160970587283373,
-0.05863015353679657,
-0.00005216554563958198,
-0.010455152951180935,
-0.014944472350180149,
0.0036494401283562183,
-0.02075488306581974,
0.024724135175347328,
-0.029147697612643242,
0.010036706924438477,
-0.06829025596380234,
0.05643032491207123,
-0.005864210892468691,
0.006360367406159639,
-0.0014974360819905996,
-0.022906886413693428,
-0.028502097353339195,
0.027665207162499428,
-0.030032411217689514,
-0.04201189801096916,
0.024425245821475983,
0.007424413692206144,
0.041892342269420624,
-0.0031562724616378546,
-0.02563275769352913,
-0.00890690553933382,
0.03371473029255867,
0.0036494401283562183,
-0.003679329063743353,
0.02338510937988758,
0.017861632630228996,
0.020826615393161774,
0.021460261195898056,
0.0366797111928463,
0.06140384450554848,
-0.00658154534175992,
-0.0010625519789755344,
-0.011907755397260189,
-0.02348075434565544,
0.02450893446803093,
0.031730104237794876,
-0.04696150869131088,
0.018232256174087524,
0.06197771430015564,
0.055760812014341354,
-0.03452770784497261,
0.06953363865613937,
-0.0615951344370842,
-0.02835863083600998,
0.003730140160769224,
-0.020085370168089867,
0.02895640954375267,
0.03433641791343689,
-0.04679413139820099,
0.024939334020018578,
0.02948245406150818,
0.011590932495892048,
-0.01796923391520977,
-0.0038078513462096453,
0.055760812014341354,
0.006509812083095312,
-0.027880406007170677,
-0.008225437253713608,
-0.003948329482227564,
0.013725003227591515,
0.0670468807220459,
0.015052071772515774,
-0.06953363865613937,
0.01568571850657463,
-0.018853945657610893,
-0.020898349583148956,
0.0366797111928463,
-0.02663702704012394,
-0.008189571090042591,
0.042800966650247574,
-0.000845857139211148,
0.0810588151216507,
0.06236029416322708,
0.005514509975910187,
0.034073397517204285,
-0.01529118325561285,
-0.017849678173661232,
-0.017550786957144737,
0.04748755320906639,
-0.053321875631809235,
0.054613079875707626,
0.018806124106049538,
0.008984616957604885,
-0.01048504188656807,
-0.01988212577998638,
0.002669082721695304,
0.05002213642001152,
0.023337287828326225,
0.01721603237092495,
-0.023026442155241966,
-0.04327918961644173,
0.026684848591685295,
-0.01661825366318226,
0.039142560213804245,
0.027808673679828644,
-0.02895640954375267,
0.0025853936094790697,
-0.015255317091941833,
0.017861632630228996,
-0.014442337676882744,
-0.0050332979299128056,
-0.02422199957072735,
-0.007263013161718845,
-0.028023874387145042,
-0.022584086284041405,
0.041151098906993866,
0.03653624653816223,
-0.031562723219394684,
0.007478213869035244,
0.04232274368405342,
-0.06489487737417221,
0.025943603366613388,
-0.014215181581676006,
0.03039107844233513,
-0.05217413976788521,
0.020766837522387505,
0.016678031533956528,
-0.03663188964128494,
0.0075559248216450214,
-0.00002173953726014588,
-0.018638744950294495,
0.02635009214282036,
-0.06054304540157318,
-0.02319382131099701,
-0.03290174901485443,
0.03146708011627197,
0.008948749862611294,
0.008781371638178825,
-0.029099876061081886,
0.006760878954082727,
0.03577108681201935,
-0.06594696640968323,
0.0027408162131905556,
0.013940203003585339,
-0.004967542365193367,
-0.024305690079927444,
0.03177792578935623,
-0.028119517490267754,
0.007316813338547945,
0.06059086695313454,
0.03514939919114113,
-0.024174178019165993,
-0.0035717287100851536,
-0.0005488357273861766,
0.00848248228430748,
-0.011578977108001709,
-0.04397261515259743,
0.03223223611712456,
-0.005302298814058304,
0.010323640890419483,
-0.02816734090447426,
0.04002727195620537,
0.028382541611790657,
0.010694264434278011,
-0.04911351203918457,
-0.010885553434491158,
-0.012828335165977478,
0.03409730643033981,
0.04901786893606186,
0.032160501927137375,
0.02857382968068123,
-0.03859260305762291,
-0.03402557224035263,
0.006790767889469862,
-0.007896658964455128,
-0.0027228828985244036,
-0.002204309683293104,
-0.01108282059431076,
-0.008942771703004837,
-0.009588372893631458,
-0.018519189208745956,
-0.008685726672410965,
-0.0021639594342559576,
0.018961545079946518,
0.03027152270078659,
0.044403016567230225,
-0.03524504229426384,
0.008817238733172417,
0.046124618500471115,
0.038329582661390305,
0.006641323212534189,
0.04172496497631073,
0.016797587275505066,
0.00331767275929451,
0.013438069261610508,
0.025752313435077667,
0.03048672340810299,
-0.012912023812532425,
-0.03385819494724274,
-0.017072563990950584,
-0.01718016527593136,
0.008398793637752533,
-0.018459411337971687,
-0.020181015133857727,
-0.01584113948047161,
-0.009552506729960442,
-0.02300253137946129,
0.02682831510901451,
-0.00805805902928114,
-0.02481977827847004,
-0.045622482895851135,
-0.02635009214282036,
-0.027306539937853813,
-0.03208877146244049,
0.01562594063580036,
-0.005341154057532549,
-0.0025510212872177362,
0.01706060953438282,
-0.029912855476140976,
-0.01621176302433014,
-0.01659434102475643,
0.017479054629802704,
-0.030917122960090637,
-0.03323650732636452,
-0.012637045234441757,
0.0037719847168773413,
0.02160372957587242,
-0.016259584575891495,
-0.014035847969353199,
-0.011901777237653732,
0.01596069522202015,
-0.02541755698621273,
0.020683148875832558,
-0.021209195256233215,
0.010335597209632397,
-0.025680581107735634,
0.02388724312186241,
0.002504693577066064,
0.0061870114877820015,
-0.04648328572511673,
-0.021639594808220863,
-0.006599478889256716,
0.016128074377775192,
-0.006772834807634354,
0.0013778803404420614,
-0.016725853085517883,
0.01636718586087227,
-0.015637895092368126,
-0.022201508283615112,
0.019870169460773468,
-0.011184442788362503,
-0.006557634100317955,
-0.022871019318699837,
0.019762570038437843,
-0.03907082602381706,
0.013497847132384777,
0.00511698704212904,
-0.032566994428634644,
0.05270018428564072,
0.031754013150930405,
-0.04753537476062775,
-0.01330655813217163,
0.005090087186545134,
0.008805282413959503,
-0.006880434695631266,
-0.04476168379187584,
0.007944481447339058,
0.01796923391520977,
-0.018638744950294495,
0.038951270282268524,
-0.060112643986940384,
0.0021056761033833027,
-0.020181015133857727,
0.02147221751511097,
0.019045235589146614,
0.030917122960090637,
0.03957296162843704,
-0.007591791916638613,
-0.027665207162499428,
0.017168208956718445,
0.02147221751511097,
-0.005176764912903309,
-0.011280087754130363,
0.004707508720457554,
-0.02955418825149536,
-0.0072151911444962025,
0.006234833505004644,
-0.03340388461947441,
-0.00012319849338382483,
0.033164773136377335,
-0.0034491841215640306,
0.011537132784724236,
0.005577276926487684,
-0.009175905957818031,
0.03603411093354225,
-0.0008563182200305164,
-0.0241383109241724,
0.028789030387997627,
0.0013248274335637689,
0.038520872592926025,
0.007992303930222988,
-0.004283085465431213,
0.003565751016139984,
-0.016988875344395638,
-0.02864556387066841,
0.010323640890419483,
-0.0024254878517240286,
-0.013665225356817245,
0.0015049083158373833,
-0.020635327324271202,
-0.008398793637752533,
-0.022081952542066574,
-0.002376171061769128,
0.020587503910064697,
0.0033983730245381594,
-0.02404266595840454,
-0.022906886413693428,
0.048754844814538956,
-0.03125188127160072,
-0.009964973665773869,
0.034886375069618225,
-0.032136593014001846,
0.005675910506397486,
0.004274119157344103,
0.0007367624784819782,
0.008984616957604885,
0.015028160996735096,
-0.002888766350224614,
0.005690854974091053,
-0.007567880675196648,
-0.020145148038864136,
0.022249329835176468,
0.022153684869408607,
-0.01239793375134468,
-0.003135350299999118,
-0.0294585432857275,
0.029195521026849747,
-0.003383428556844592,
0.015757450833916664,
-0.008279237896203995,
0.01411953754723072,
0.014669493772089481,
0.048874400556087494,
0.046937596052885056,
-0.0471527986228466,
-0.0007431138656102121,
0.010598619468510151,
-0.028812941163778305,
0.010443196631968021,
-0.01975061371922493,
0.006282655987888575,
-0.0025853936094790697,
-0.01621176302433014,
0.0032698505092412233,
0.09258399158716202,
0.026397915557026863,
-0.009444906376302242,
-0.04696150869131088,
-0.01890176720917225,
0.0017425253754481673,
0.02460457943379879,
-0.04787013307213783,
-0.0192484799772501,
0.003359517315402627,
-0.011561043560504913,
0.005992733407765627,
-0.03412121906876564,
-0.0006739957025274634,
-0.001111121498979628,
-0.01994190365076065,
-0.00012338529631961137,
-0.002453882247209549,
-0.015721583738923073,
-0.017646431922912598,
-0.008117836900055408,
-0.022309107705950737,
-0.015721583738923073,
-0.014621671289205551,
0.027019605040550232,
0.0022969653364270926,
-0.017574699595570564,
-0.020372305065393448,
-0.01386846974492073,
-0.01725189760327339,
0.023145997896790504,
0.0005589232314378023,
0.02917160838842392,
-0.024269822984933853,
0.03070192225277424,
-0.024329600855708122,
-0.026708759367465973,
-0.014203226193785667,
-0.00042890635086223483,
0.017239943146705627,
0.04375741258263588,
-0.0004079840728081763,
-0.025943603366613388,
-0.013402202166616917,
-0.0018292033346369863,
-0.013533714227378368,
0.004913742188364267,
0.028071695938706398,
0.03208877146244049,
0.03445597365498543,
-0.0023881266824901104,
-0.0054995655082166195,
-0.028717298060655594,
-0.010927397757768631,
0.004354819189757109,
0.007591791916638613,
-0.024891512468457222,
0.0692945271730423,
-0.029841121286153793,
0.013569580391049385,
0.00994106288999319,
-0.03940558433532715,
-0.028908586129546165,
-0.0035956399515271187,
-0.030414989218115807,
0.020778793841600418,
-0.032853927463293076,
-0.0028962385840713978,
0.008356948383152485,
0.0007031374261714518,
0.0030755724292248487,
0.0032011058647185564,
-0.00004133080437895842,
0.034886375069618225,
-0.011483332142233849,
0.005167798604816198,
0.02601533755660057,
0.011937644332647324,
0.01081382017582655,
-0.02725871652364731,
-0.004665663931518793,
0.008613993413746357,
-0.016391096636652946,
-0.020575549453496933,
-0.016128074377775192,
-0.03228005766868591,
-0.026995694264769554,
0.0134739363566041,
-0.02450893446803093,
-0.017789900302886963,
-0.0321844145655632,
0.032351791858673096,
-0.0034103284124284983,
0.012469667010009289,
-0.007830902934074402,
0.010006817989051342,
0.00369427353143692,
0.002828988479450345,
-0.017072563990950584,
0.0179094560444355,
-0.014155403710901737,
0.008135770447552204,
-0.0027602440677583218,
0.01677367463707924,
-0.013677180744707584,
-0.004590941593050957,
-0.01756274327635765,
0.021866751834750175,
-0.005009387154132128,
0.018507234752178192,
-0.012876156717538834,
0.025776226073503494,
-0.024126354604959488,
-0.006988035049289465,
-0.019212612882256508,
-0.03129970282316208,
-0.010771974921226501,
0.017957277595996857,
-0.012063177302479744,
-0.010299730114638805,
-0.01235011126846075,
0.023062309250235558,
-0.043183546513319016,
0.041485853493213654,
-0.027115250006318092,
0.016893230378627777,
0.03381037339568138,
-0.08440637588500977,
0.00924763921648264,
0.0037032400723546743,
-0.033475618809461594,
0.0007064999081194401,
0.0017843699315562844,
-0.013904336839914322,
0.01621176302433014,
-0.005209642928093672,
-0.01680954173207283,
0.011794176883995533,
-0.029697654768824577,
0.01990603655576706,
0.03204094618558884,
0.02957809902727604,
-0.001658836379647255,
-0.006145166698843241,
-0.0680033266544342,
0.0001171272961073555,
-0.003780951490625739,
-0.020336437970399857,
-0.010078552179038525,
-0.014824916608631611,
0.022739509120583534,
-0.011483332142233849,
0.031538814306259155,
-0.0031801837030798197,
0.018459411337971687,
-0.06838590651750565,
-0.015243361704051495,
-0.014908605255186558,
0.027689117938280106,
-0.01905719004571438,
0.0009041405282914639,
-0.02369595505297184,
-0.04488123953342438,
0.04559857398271561,
-0.026206625625491142,
-0.006028600037097931,
0.023719865828752518,
0.01147137675434351,
0.0025510212872177362,
0.0243535116314888,
-0.01702474243938923,
-0.04767884314060211,
-0.00961228460073471,
-0.020611416548490524,
0.025465380400419235,
0.005894099827855825,
-0.01162679959088564,
0.02156786248087883,
-0.0337386392056942,
-0.020025592297315598,
0.010544819757342339,
-0.029291164129972458,
-0.009080260992050171,
-0.026708759367465973,
0.029721565544605255,
0.010957286693155766,
0.03452770784497261,
-0.015482473187148571,
0.04442692548036575,
0.05537823587656021,
-0.018483322113752365,
-0.02137657254934311,
0.004839019849896431,
-0.03847304731607437,
0.024891512468457222,
-0.04048158600926399,
0.017347542569041252,
-0.011214331723749638,
0.03608193248510361,
-0.036512333899736404,
0.035579800605773926,
-0.014765138737857342,
-0.017287764698266983,
-0.04174887761473656,
0.006402211729437113,
0.002957510994747281,
0.0028230107855051756,
0.01777794398367405,
-0.007597769610583782,
0.00209372048266232,
0.00787274818867445,
-0.03981207311153412,
-0.017144298180937767,
-0.02460457943379879,
0.021017905324697495,
0.03677535802125931,
0.012093066237866879,
0.015231405384838581,
-0.021520039066672325,
-0.009546528570353985,
-0.013055490329861641,
-0.028286896646022797,
-0.031156234443187714,
-0.018961545079946518,
-0.025489291176199913,
-0.016295451670885086,
-0.005245509557425976,
0.028286896646022797,
-0.013485891744494438,
-0.02582404762506485,
-0.03706229105591774,
-0.04739191010594368,
-0.009815528988838196,
0.06862501800060272,
0.0058253551833331585,
-0.01474122703075409,
0.005311265122145414,
0.0247002225369215,
-0.0027169049717485905,
-0.0015168639365583658,
-0.0184713676571846,
0.0029306109063327312,
-0.005840299651026726,
0.031754013150930405,
-0.03476681932806969,
0.04048158600926399,
0.008667794056236744,
0.06709469854831696,
0.016415007412433624,
-0.02532191388309002,
-0.05662161484360695,
-0.013593492098152637,
-0.01568571850657463,
-0.03603411093354225,
0.037707891315221786,
-0.004743375349789858,
-0.0045281751081347466,
0.009791618213057518,
-0.009504684247076511,
-0.02212977409362793,
0.0012269411236047745,
-0.028932496905326843,
0.05140898376703262,
0.001489963848143816,
0.01568571850657463,
-0.001960714813321829,
0.02419808879494667,
0.000498398148920387,
-0.0269478727132082,
-0.0013689136831089854,
-0.022643864154815674,
0.032614815980196,
-0.005137909669429064,
-0.031562723219394684,
0.04806142300367355,
-0.03146708011627197,
0.007932526059448719,
-0.03718184679746628,
0.02773693948984146,
0.021962396800518036,
0.049878668040037155,
0.0015392806380987167,
0.029793299734592438,
0.0005548135377466679,
-0.006725012324750423,
-0.015159672126173973,
0.014717316254973412,
-0.004581975284963846,
0.06470358371734619,
-0.037923090159893036,
0.0016947031253948808,
0.010742085985839367,
-0.0133663360029459,
-0.006999990437179804,
0.02071901597082615,
0.0516480952501297,
-0.01076599769294262,
-0.009923129342496395,
-0.07072919607162476,
0.02406657673418522,
-0.018806124106049538,
-0.012804423458874226,
0.018889812752604485,
0.01887785643339157,
0.011967533268034458,
0.009104172699153423,
0.02450893446803093,
-0.018913723528385162,
0.006659256760030985,
0.019427813589572906,
0.047654930502176285,
0.029530277475714684,
-0.013593492098152637,
-0.003401361871510744,
-0.0276412945240736,
0.03997945040464401,
0.00837488193064928,
-0.027067428454756737,
-0.009839440695941448,
0.026852227747440338,
0.05399138852953911,
0.03483855351805687,
-0.004109730012714863,
-0.025991424918174744,
0.010903486981987953,
-0.018734389916062355,
-0.037014469504356384,
-0.047439731657505035,
0.01391629222780466,
0.014358649030327797,
-0.018447456881403923,
-0.00008452966721961275,
0.04323136806488037,
-0.003006827784702182,
-0.008727571927011013,
-0.010443196631968021,
0.03471899777650833,
0.02087443880736828,
0.03029543347656727,
-0.00924763921648264,
0.028621653094887733,
-0.011100754141807556,
-0.01050297450274229,
0.007920569740235806,
0.024269822984933853,
-0.03636886551976204,
-0.012385978363454342,
-0.05011777952313423,
-0.01533900573849678,
-0.013067446649074554,
-0.00901450589299202,
-0.026158804073929787,
0.011537132784724236,
0.021137461066246033,
0.009319372475147247,
0.0067489235661923885,
0.012140888720750809,
-0.015410739928483963,
0.0013517275219783187,
0.03646451234817505,
0.005221598315984011,
0.03474290668964386,
0.001856103423051536,
-0.04466603696346283,
-0.03950122743844986,
0.011943621560931206,
0.01570962928235531,
0.04007509723305702,
0.015578117221593857,
0.030414989218115807,
-0.043303102254867554,
0.009229705668985844,
0.015865052118897438,
0.034695085138082504,
-0.017479054629802704,
0.005983766634017229,
-0.02948245406150818,
-0.039046917110681534,
-0.008512371219694614,
-0.004450463689863682,
-0.010066595859825611,
0.056143391877412796,
0.00842270441353321,
-0.020922260358929634,
0.023265553638339043,
0.007621680852025747,
-0.001554225105792284,
-0.00537702115252614,
0.007071724161505699,
-0.005888122133910656,
-0.01266095694154501,
0.034169040620326996,
-0.014597760513424873,
0.018686568364501,
0.014920560643076897,
0.009337306022644043,
0.038138292729854584,
0.020121237263083458,
0.017885543406009674,
0.00014187907800078392,
0.01988212577998638,
-0.004154563415795565,
0.006157122552394867,
0.01388042513281107,
0.019487591460347176,
-0.01533900573849678,
-0.010443196631968021,
-0.02206999622285366,
0.023815510794520378,
-0.03534068539738655,
0.04067287594079971,
0.013904336839914322,
0.00843465980142355,
0.013988025486469269,
-0.0062228781171143055,
-0.0069820573553442955,
0.008584104478359222,
-0.012140888720750809,
0.008279237896203995,
-0.031227968633174896,
-0.011997422203421593,
-0.018268123269081116,
0.012039266526699066,
0.0023432932794094086,
0.020742926746606827,
-0.003464128589257598,
-0.003972240723669529,
0.023492710664868355,
0.018447456881403923,
0.0017171198269352317,
-0.01756274327635765,
0.015781361609697342,
-0.029793299734592438,
-0.03392992913722992,
-0.03868824988603592,
0.04892222210764885,
-0.01874634623527527,
-0.024580666795372963,
0.01104695349931717,
0.006485900841653347,
-0.012840290553867817,
0.0039005072321742773,
0.008888971991837025,
-0.016259584575891495,
-0.0031592613086104393,
0.004450463689863682,
0.012421845458447933,
-0.009223728440701962,
0.011453443206846714,
0.015578117221593857,
0.0013614414492622018,
-0.03495810925960541,
-0.00554141029715538,
0.010365486145019531,
0.011184442788362503,
-0.003368484089151025,
-0.008823215961456299,
0.028191251680254936,
-0.01260117907077074,
0.01311526820063591,
0.000354183983290568,
0.003404350718483329,
0.018602877855300903,
0.0033654950093477964,
-0.015147716738283634,
-0.0138206472620368,
0.015374872833490372,
-0.01677367463707924,
-0.02278733067214489,
-0.012589222751557827,
0.04753537476062775,
-0.015064028091728687,
-0.012732690200209618,
-0.04595724120736122,
0.008333037607371807,
-0.04466603696346283,
-0.003984196111559868,
0.05293929576873779,
-0.00881126057356596,
-0.04392479360103607,
0.04119892045855522,
0.013007668778300285,
-0.020993994548916817,
-0.001284477417357266,
-0.009253617376089096,
0.0024150267709046602,
-0.016175895929336548,
-0.01787358894944191,
0.02241670712828636,
0.02996067702770233,
-0.0062228781171143055,
0.013689136132597923,
0.02282319776713848,
-0.018578967079520226,
-0.031227968633174896,
-0.022428663447499275,
-0.037516601383686066,
0.018076833337545395,
0.008111859671771526,
-0.024628490209579468,
0.007454302627593279,
0.0008802294032648206,
0.012134911492466927,
0.029506364837288857,
0.02222541905939579,
0.011226287111639977,
0.021687418222427368,
0.02216564118862152,
-0.002787143923342228,
0.016140028834342957,
-0.029434632509946823,
0.015159672126173973,
-0.02438937872648239,
-0.01621176302433014,
-0.036392778158187866,
0.015279227867722511,
-0.020838571712374687,
-0.027473917230963707,
-0.03534068539738655,
-0.012087089009582996,
0.0045042638666927814,
-0.023779643699526787,
-0.009026461280882359,
0.009385128505527973,
-0.010730130597949028,
-0.021340705454349518,
-0.020587503910064697,
-0.0033445728477090597,
-0.010096484795212746,
0.025943603366613388,
-0.007896658964455128,
0.0247002225369215,
0.026804404333233833,
-0.0005383745883591473,
0.023420976474881172,
0.0037510625552386045,
-0.011770266108214855,
-0.0398838073015213,
0.005338165443390608,
-0.059490952640771866,
0.032614815980196,
-0.04588550701737404,
-0.010771974921226501,
-0.02153199538588524,
-0.03754051402211189,
-0.036105845123529434,
0.007352679967880249,
0.019953858107328415,
0.02776085026562214,
-0.021902618929743767,
0.00587018858641386,
-0.014944472350180149,
0.0013689136831089854,
0.0225362628698349,
-0.003619551192969084,
-0.056047748774290085,
-0.003628517733886838,
-0.009056350216269493,
-0.02044403739273548,
0.012469667010009289,
-0.028621653094887733,
-0.04839617758989334,
0.011572998948395252,
-0.0002652643888723105,
0.00853030476719141,
-0.010114418342709541,
0.023648131638765335,
-0.01010844111442566,
-0.03259090334177017,
0.029936766251921654,
0.010963264852762222,
-0.009462839923799038,
-0.014035847969353199,
-0.0022700652480125427,
-0.007310835644602776,
0.0032698505092412233,
0.03644059970974922,
0.014286914840340614,
0.01386846974492073,
-0.01677367463707924,
0.004217329900711775,
-0.019738659262657166,
-0.014908605255186558,
-0.04696150869131088,
-0.015853095799684525,
0.008984616957604885,
0.011124664917588234,
-0.035603709518909454,
-0.013198957778513432,
0.0025569992139935493,
0.040362030267715454,
-0.01822029985487461,
0.013402202166616917,
0.005374032072722912,
-0.02222541905939579,
0.001188085530884564,
-0.03483855351805687,
0.0020458982326090336,
0.027784762904047966,
0.014382559806108475,
0.010024751536548138,
0.03658406808972359,
-0.01316309068351984,
0.01727581024169922,
-0.0057924771681427956,
0.011274109594523907,
-0.0366797111928463,
-0.0025435490533709526,
0.014824916608631611,
0.01643892005085945,
-0.023683998733758926,
0.027378272265195847,
0.026852227747440338,
0.007149435579776764,
-0.03381037339568138,
0.05064382776618004,
-0.009432950988411903,
-0.024891512468457222,
-0.012780512683093548,
-0.004913742188364267,
0.018507234752178192,
-0.01222457829862833,
0.013653269968926907,
0.01184797752648592,
-0.017204076051712036,
-0.01386846974492073,
0.002793121850118041,
0.002207298530265689,
-0.005093076266348362,
-0.001037146314047277,
-0.011830043978989124,
0.004743375349789858,
0.03868824988603592,
-0.05198284983634949,
-0.08220655471086502,
0.03242352604866028,
0.020527726039290428,
-0.018830034881830215,
-0.004489319398999214,
-0.01808878965675831,
0.005060198251157999,
0.015040116384625435,
-0.0788111686706543,
-0.012649000622332096,
0.007914592511951923,
0.018985457718372345,
0.009199816733598709,
0.004812119994312525,
0.001393571961671114,
0.0027497827541083097,
-0.010150285437703133,
0.01940390281379223,
-0.01391629222780466,
0.008165659382939339,
0.0473201759159565,
-0.00663534551858902,
-0.007884703576564789,
0.030964946374297142,
0.005039276089519262,
-0.009229705668985844,
0.014143448323011398,
-0.020838571712374687,
0.032853927463293076,
-0.016044385731220245,
0.0019592202734202147,
-0.012780512683093548,
-0.0020414148457348347,
-0.023122087121009827,
-0.005780521780252457,
-0.023241642862558365,
-0.017287764698266983,
0.02350466512143612,
0.0037002512253820896,
0.0267326720058918,
-0.007627658545970917,
-0.005744655150920153,
0.037325311452150345,
0.02416222169995308,
-0.004423563834279776,
0.009319372475147247,
0.006940212566405535,
-0.02654138207435608,
-0.028908586129546165,
0.019081102684140205,
-0.02874120883643627,
-0.005224587395787239,
0.015362917445600033,
0.0227514635771513,
-0.0024792877957224846,
-0.002719893818721175,
-0.015183583833277225,
-0.0036255288869142532,
-0.023767687380313873,
-0.013019624166190624,
-0.005224587395787239,
-0.001618486363440752,
-0.010383418761193752,
-0.016678031533956528,
-0.018005099147558212,
-0.015327050350606441,
0.008440637961030006,
-0.04600506275892258,
0.03993162885308266,
0.012266422621905804,
0.014669493772089481,
0.002748288447037339,
0.013557625003159046,
-0.033069126307964325,
0.012804423458874226,
-0.014597760513424873,
0.01856701262295246,
-0.030510634183883667,
-0.01915283501148224,
-0.02187870629131794,
-0.03993162885308266,
-0.018794167786836624,
0.011949599720537663,
-0.042896613478660583,
-0.007382569368928671,
-0.0065277451649308205,
0.007071724161505699,
0.016391096636652946,
0.03299739584326744,
0.022715596482157707,
0.015135761350393295,
-0.014669493772089481,
-0.012768557295203209,
0.012816378846764565,
0.04315963387489319,
0.009755751118063927,
-0.00875148270279169,
0.007926547899842262,
-0.023958977311849594,
-0.00738854706287384,
-0.012756600975990295,
-0.04648328572511673,
-0.007681458722800016,
-0.011584954336285591,
-0.006246789358556271,
0.015327050350606441,
-0.007795036770403385,
-0.033069126307964325,
0.030558455735445023,
-0.02172328531742096,
-0.016833452507853508,
0.003915451467037201,
0.008052081800997257,
0.025752313435077667,
0.021209195256233215,
-0.0008929321775212884,
0.013748914003372192,
0.0012545883655548096,
0.016331318765878677,
0.012792468070983887,
0.0029515333008021116,
0.07895463705062866,
-0.022297151386737823,
-0.04009900614619255,
0.0031473056878894567,
-0.00984541792422533,
-0.0378035344183445,
0.006450034212321043,
0.01316309068351984,
-0.01212893333286047,
0.025752313435077667,
-0.02613489329814911,
0.006070444360375404,
0.007155413273721933,
0.0075081028044223785,
0.02075488306581974,
0.039955541491508484,
-0.021113550290465355,
0.00801023654639721,
-0.0041665188036859035,
-0.014191270805895329,
-0.02425786666572094,
-0.0031054613646119833,
-0.022404752671718597,
0.006354389246553183,
-0.012374022975564003,
0.012983757071197033,
0.0168693196028471,
0.03242352604866028,
-0.000174850327312015,
-0.009074283763766289,
-0.025991424918174744,
0.001998075982555747,
0.01189580000936985,
-0.03077365644276142,
-0.0017724144272506237,
0.02783258445560932,
-0.001987614668905735,
0.011949599720537663,
0.010496997274458408,
0.0056280880235135555,
-0.03349952772259712,
-0.009068305604159832,
-0.023982888087630272,
0.017491009086370468,
-0.017227986827492714,
-0.0036165621131658554,
0.06599479168653488,
-0.04760710895061493,
-0.020420126616954803,
0.007932526059448719,
0.050978582352399826,
-0.027282627299427986,
0.007944481447339058,
-0.002062337240204215,
-0.009970951825380325,
-0.005036287009716034,
0.018076833337545395,
0.0031204058323055506,
0.013844558969140053,
-0.003927407320588827,
0.02135266177356243,
-0.027091339230537415,
0.018794167786836624,
0.020958127453923225,
0.025967514142394066,
-0.015159672126173973,
-0.03249526023864746,
0.02733045071363449,
-0.0028723275754600763,
0.035292863845825195,
-0.01240988913923502,
0.0019771535880863667,
0.005571299232542515,
0.0000694917980581522,
-0.012577267363667488,
0.0044923084788024426,
0.02582404762506485,
-0.0035388509277254343,
0.01702474243938923,
-0.010969242081046104,
-0.0015146222431212664,
-0.03361908346414566,
-0.016486741602420807,
-0.016104163601994514,
0.011853954754769802,
-0.028980320319533348,
0.008912882767617702,
-0.009935084730386734,
0.01256531197577715,
0.004253196530044079,
0.010688286274671555,
0.012696823105216026,
-0.019475635141134262,
0.00777112552896142,
0.015374872833490372,
-0.027091339230537415,
-0.00903243850916624,
-0.01715625450015068,
0.015028160996735096,
-0.019332168623805046,
-0.04050549492239952,
0.006850545760244131,
0.0055922213941812515,
-0.007113568484783173,
-0.00009676545596448705,
-0.019463680684566498,
0.011877866461873055,
0.013139179907739162,
0.011865911073982716,
-0.001494447235018015,
0.012194689363241196
] | 2025-01-15 | 50 | 39811687 | [
"cell health",
"CAR)-T cell therapy",
"robust cell functionality",
"stem cell memory T cells",
"multi-edited CAR-T cells",
"improved immunological synapse strength",
"edited T cells",
"certain hematologic cancers",
"further genetic modifications",
"higher oxidative phosphorylation levels",
"Solupore",
"T cells",
"next-generation CAR-T cells",
"triple-edited CAR-T cells",
"Chimeric antigen receptor",
"solid tumors",
"similar proportions",
"CD19",
"lentiviral transduction",
"hematological malignancies",
"manufacturing processes",
"CAR)-T",
"a Good Manufacturing Practice-aligned, non-viral physicochemical transfection system",
"apoptosis",
"function",
"a CD19 CAR",
"electroporation",
"a Good Manufacturing Practice",
"CRISPR-Cas9 ribonucleoproteins",
"an industry standard"
] | [
"CAR-T",
"CAR-T manufacturing",
"Solupore",
"adoptive cell therapy",
"cell avidity",
"cell cytotoxicity",
"genetic engineering",
"metabolism",
"non-viral transfection",
"stem cell memory"
] | 0 | 10.1016/j.omtm.2024.101389 | [
"O'Sullivan",
"Case",
"McCrudden",
"Hackett",
"Gallagher",
"Martin",
"Johnson",
"Mahadik",
"Kienzle",
"Lim",
"Nashat",
"Srinivasan",
"Lowdell",
"O'Flynn",
"Frankish"
] | [
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"University College London, Cancer Institute, London, UK.",
"Avectas, Cherrywood Business Park, Dublin, Ireland.",
"Avectas, Cherrywood Business Park, Dublin, Ireland."
] | [
"39811687",
"25317870",
"25319501",
"27111235",
"29385370",
"29385376",
"38326614",
"33824268",
"19525962",
"21926977",
"15931392",
"15980149",
"19805141",
"26942092",
"28060797",
"21737507",
"27226436",
"37433264",
"6329708",
"1912274",
"12648161",
"25939984",
"33941482",
"28358921",
"21765414",
"23746840",
"29677474",
"28507025",
"35418687",
"36732477",
"38066564",
"38491381",
"35621683",
"32433532",
"32808434",
"9412459",
"18806755",
"18314051",
"20645005",
"32624246",
"11323696",
"20351312",
"20835230",
"20023662",
"27396447",
"29403049",
"27496729",
"26551880",
"28285833",
"36717905"
] | [] | 8.914077 | 3.011367 |
39810257 | 30 | Construction and characterization of chimeric FcγR T cells for universal T cell therapy. | Several approaches are being explored for engineering off-the-shelf chimeric antigen receptor (CAR) T cells. In this study, we engineered chimeric Fcγ receptor (FcγR) T cells and tested their potential as a versatile platform for universal T cell therapy.
Chimeric FcγR (CFR) constructs were generated using three distinct forms of FcγR, namely CD16A, CD32A, and CD64. The functionality of CFR T cells was evaluated through degranulation assays, specific target lysis experiments, in vitro cytokine production analysis, and assessment of tumor xenograft destruction specificity in mouse models using different monoclonal antibodies (MoAbs).
Three types of CFR T cells were engineered, 16s3, 32-8a, 64-8a CFR T cells. In the presence of rituximab (RTX), cytotoxicity of all three types of CFR T cells against CD20
The anti-tumor effects of the CFR T cells in vitro and in xenograft mouse models are mediated by specific MoAbs such as RTX and herceptin. The CFR T cells therefore have the features of universal T cells with specificity directed by MoAbs. 16s3 CFR T cells are chosen for clinical trials. | [
0.023621099069714546,
0.008070860058069229,
0.03439496457576752,
0.04322266951203346,
-0.026508545503020287,
-0.025198383256793022,
-0.025325583294034004,
0.012847231701016426,
-0.018126044422388077,
0.012402030639350414,
-0.007040537428110838,
-0.027577029541134834,
-0.043070025742053986,
0.024524221196770668,
0.01761724427342415,
-0.03396248444914818,
0.049633562564849854,
-0.042077865451574326,
0.013928434811532497,
0.017311962321400642,
0.02879815176129341,
0.011549788527190685,
-0.010086985304951668,
0.01059578638523817,
-0.007352178450673819,
-0.02541462332010269,
0.03340280428528786,
0.020199410617351532,
-0.06212463602423668,
-0.03818553686141968,
0.009241103194653988,
-0.0228833369910717,
-0.03648105263710022,
0.024625981226563454,
-0.008077220059931278,
0.020809972658753395,
0.00568903423845768,
0.01803700439631939,
-0.0228960569947958,
0.0018189644906669855,
0.033631764352321625,
0.016854042187333107,
0.018087884411215782,
0.06370192021131516,
-0.05902094766497612,
-0.01620532013475895,
-0.01475523691624403,
0.010417706333100796,
0.009845304302871227,
-0.0012322530383244157,
-0.020759092643857002,
-0.007530258968472481,
-0.05311885103583336,
0.03266504034399986,
-0.05484877526760101,
0.06716176867485046,
-0.059122707694768906,
-0.015416678041219711,
-0.007708339020609856,
0.010379546321928501,
-0.012758191674947739,
-0.04212874546647072,
0.035310808569192886,
-0.019830528646707535,
-0.03798201307654381,
0.036379288882017136,
-0.05439085513353348,
0.006235995329916477,
0.011619748547673225,
0.05042220652103424,
-0.015900040045380592,
0.0022975557949393988,
0.043349869549274445,
0.009495503269135952,
0.04584299400448799,
-0.026177825406193733,
0.0024358860682696104,
0.06176847219467163,
0.002103575272485614,
-0.01569651998579502,
0.0218402948230505,
0.018622126430273056,
-0.005084832664579153,
-0.04678427800536156,
0.00944462325423956,
-0.03587048873305321,
0.03421688452363014,
-0.02480406127870083,
-0.03342824429273605,
0.0018921047449111938,
0.0027236768510192633,
-0.0033103881869465113,
-0.0641089603304863,
0.05500141531229019,
-0.005262913182377815,
0.023824619129300117,
-0.02063189074397087,
-0.02844199165701866,
0.013330592773854733,
0.023010537028312683,
0.06227727606892586,
-0.008681422099471092,
-0.028543751686811447,
-0.00633775582537055,
0.04887036234140396,
-0.008077220059931278,
-0.042077865451574326,
0.012879031710326672,
0.01766812428832054,
-0.012548311613500118,
0.06141231209039688,
-0.009915264323353767,
-0.011880509555339813,
0.03495464846491814,
-0.006767056882381439,
-0.05571373924612999,
-0.0204283706843853,
-0.004219870548695326,
-0.0030655276495963335,
0.039203137159347534,
-0.01880020648241043,
0.02198021486401558,
0.04797995835542679,
-0.016815882176160812,
-0.01553115900605917,
-0.016459720209240913,
0.059275347739458084,
-0.03439496457576752,
-0.052152130752801895,
-0.056731339544057846,
0.046580757945775986,
-0.01168970949947834,
0.028874471783638,
-0.006445875857025385,
-0.04029706120491028,
-0.011021907441318035,
0.008172620087862015,
-0.04818347841501236,
-0.05973326787352562,
-0.008274381048977375,
0.0028254371136426926,
-0.03185096010565758,
0.006471316330134869,
-0.018965566530823708,
-0.02683926746249199,
-0.03408968448638916,
-0.03851625695824623,
0.01175966951996088,
0.0012886981712654233,
0.025694463402032852,
-0.06344752013683319,
0.025681743398308754,
0.08110292255878448,
-0.019054608419537544,
0.0016178290825337172,
-0.066195048391819,
-0.012580111622810364,
0.042434025555849075,
0.023824619129300117,
-0.055968139320611954,
-0.010239625349640846,
0.02668662741780281,
-0.05556109920144081,
-0.01971604861319065,
0.03882153704762459,
-0.039890021085739136,
-0.01597636006772518,
0.03375896438956261,
-0.07555698603391647,
0.0027761468663811684,
0.0005596813862212002,
-0.02788230963051319,
-0.07840627431869507,
-0.0053392332047224045,
-0.05861390754580498,
-0.02253989689052105,
0.01747732423245907,
0.02930695377290249,
-0.007460298482328653,
-0.01696852222084999,
0.008147180080413818,
-0.00410221004858613,
0.001634524087421596,
-0.020123090595006943,
-0.024397021159529686,
-0.011772389523684978,
-0.0018523546168580651,
-0.017299242317676544,
-0.010792946442961693,
-0.01123178843408823,
-0.00022140804503578693,
0.025961585342884064,
0.06365104019641876,
0.022425414994359016,
-0.0008872222388163209,
-0.03436952456831932,
0.042434025555849075,
-0.001492218696512282,
0.008325261063873768,
-0.03256328031420708,
0.013877554796636105,
-0.013852114789187908,
-0.029637673869729042,
-0.00905666220933199,
-0.020517410710453987,
-0.019665168598294258,
-0.026076065376400948,
0.04731851816177368,
-0.03828729689121246,
0.014780676923692226,
0.06919696927070618,
-0.008624181151390076,
0.005739914253354073,
0.025808943435549736,
-0.055459339171648026,
-0.022641656920313835,
-0.014106514863669872,
0.05266093090176582,
0.026254145428538322,
-0.013228832744061947,
-0.021445972844958305,
-0.002345255808904767,
0.007504818495362997,
0.016256200149655342,
-0.05642605945467949,
0.01991957053542137,
-0.011193627491593361,
-0.035539768636226654,
0.02402813918888569,
-0.037651292979717255,
-0.012764551676809788,
-0.003121177665889263,
-0.0026775666046887636,
-0.04329898953437805,
-0.04586843401193619,
0.0009619523771107197,
0.029205191880464554,
-0.00266802660189569,
0.06319312006235123,
-0.04253578558564186,
-0.019487088546156883,
-0.00026413940940983593,
0.04373146966099739,
-0.032512400299310684,
-0.024918541312217712,
-0.006817936897277832,
-0.0008951722411438823,
-0.06680560857057571,
0.01867300644516945,
0.01014422532171011,
0.01782076433300972,
0.0037301492411643267,
0.015022356994450092,
-0.018711166456341743,
0.024320701137185097,
0.04464730992913246,
0.044621869921684265,
-0.031367599964141846,
0.023710139095783234,
-0.007479378487914801,
-0.02444790117442608,
0.01260555163025856,
-0.04192522540688515,
0.010729346424341202,
-0.042154185473918915,
-0.0020733652636408806,
-0.015950920060276985,
0.027907749637961388,
0.015607479028403759,
0.02072093077003956,
0.03767673298716545,
0.02154773287475109,
0.06090351194143295,
-0.027780549600720406,
-0.04543595388531685,
-0.00010444338840898126,
-0.004207150544971228,
0.01291719265282154,
0.016154440119862556,
0.00048057868843898177,
0.000018483795429347083,
0.01766812428832054,
0.010036105290055275,
-0.011568868532776833,
-0.017998844385147095,
-0.017502764239907265,
0.02458782121539116,
-0.010971027426421642,
0.01824052631855011,
-0.013470513746142387,
0.02514750324189663,
-0.025732623413205147,
-0.02930695377290249,
-0.04421482980251312,
-0.04571579396724701,
0.03373352438211441,
-0.00866234116256237,
-0.00782281905412674,
-0.03823641687631607,
0.008350701071321964,
-0.03760041296482086,
-0.0007918219780549407,
0.003269048174843192,
-0.017795324325561523,
-0.008045420050621033,
0.003914589527994394,
-0.007549338974058628,
-0.019385328516364098,
0.07352178543806076,
0.022730696946382523,
0.013266992755234241,
-0.012726391665637493,
0.02443518117070198,
0.004464731086045504,
0.007110497914254665,
0.0069514974020421505,
0.0027252668514847755,
-0.043146345764398575,
0.01288539171218872,
-0.020886292681097984,
-0.024702301248908043,
-0.002768196864053607,
0.008414301089942455,
-0.00845246110111475,
0.01999589055776596,
-0.028162149712443352,
-0.005390113219618797,
-0.05311885103583336,
0.012389310635626316,
-0.03762585297226906,
0.02224733494222164,
-0.05403469502925873,
0.0929579883813858,
-0.032995760440826416,
0.01754092425107956,
0.002020895015448332,
-0.05739278346300125,
-0.0027872768696397543,
0.062429916113615036,
-0.01951252855360508,
0.013864834792912006,
0.006862456910312176,
-0.067619688808918,
0.05357677489519119,
0.035107288509607315,
0.01513683795928955,
-0.020084930583834648,
0.012446550652384758,
0.028085829690098763,
0.013724913820624352,
-0.015518439002335072,
0.009737184271216393,
0.003816009499132633,
-0.01059578638523817,
0.02435886114835739,
-0.007479378487914801,
-0.00767653901129961,
-0.03070615604519844,
-0.02106437273323536,
-0.005364673212170601,
0.0415436252951622,
0.03034999594092369,
-0.018838366493582726,
0.006150135304778814,
0.026381345465779305,
0.04009354114532471,
-0.021573172882199287,
0.038923297077417374,
-0.006318675819784403,
-0.05749454349279404,
-0.022908776998519897,
0.0025948865804821253,
0.04360426962375641,
-0.005536393728107214,
-0.03838905692100525,
0.0012441781582310796,
0.020097650587558746,
0.017146602272987366,
0.037498652935028076,
0.005895734764635563,
0.03724425286054611,
-0.019283568486571312,
-0.0038668897468596697,
-0.07031633704900742,
-0.014233715832233429,
0.010093345306813717,
0.02752614952623844,
-0.00040227099088951945,
-0.057748943567276,
0.027627909556031227,
-0.03353000432252884,
-0.026813827455043793,
0.02120429277420044,
-0.002868367126211524,
-0.035463448613882065,
0.052508290857076645,
0.029281513765454292,
0.06644944846630096,
0.03676089271903038,
0.018749326467514038,
-0.008198060095310211,
-0.0008872222388163209,
-0.006678016856312752,
-0.018685726448893547,
0.0039050497580319643,
0.023939099162817,
0.03930489718914032,
0.042077865451574326,
0.00784825999289751,
-0.04134010151028633,
-0.014933316968381405,
-0.01397931482642889,
0.010538546368479729,
0.044342029839754105,
-0.009737184271216393,
-0.008923102170228958,
-0.05841038376092911,
0.022361814975738525,
0.01999589055776596,
0.03177464008331299,
0.00890402216464281,
-0.04696235805749893,
0.006862456910312176,
-0.016154440119862556,
0.012739111669361591,
-0.007167737931013107,
0.010443146340548992,
0.03421688452363014,
-0.014233715832233429,
-0.0422813855111599,
-0.019525248557329178,
0.028365669772028923,
0.010169665329158306,
-0.02112797275185585,
-0.022018374875187874,
0.030044713988900185,
0.021445972844958305,
0.010169665329158306,
-0.03388616442680359,
0.049557242542505264,
-0.03281768038868904,
0.036379288882017136,
0.021585892885923386,
-0.046250034123659134,
-0.015391238033771515,
0.023328538984060287,
0.027373507618904114,
-0.02274341695010662,
-0.033809844404459,
0.014411795884370804,
-0.015950920060276985,
-0.0323852002620697,
0.007829179055988789,
-0.00221010553650558,
-0.02128061279654503,
-0.006595336366444826,
0.0535258948802948,
-0.03508184850215912,
0.027551589533686638,
0.0149714769795537,
0.06471952050924301,
-0.027551589533686638,
0.01542939804494381,
-0.002780916867777705,
-0.0026839266065508127,
0.022412694990634918,
0.012796351686120033,
-0.02142053283751011,
0.014920596964657307,
-0.04742027819156647,
-0.007205897942185402,
0.004226230550557375,
-0.007810099516063929,
0.03513272851705551,
-0.009845304302871227,
0.015238597989082336,
0.02325221709907055,
-0.0003164107911288738,
0.04464730992913246,
0.007314018439501524,
-0.006309135816991329,
-0.004089490044862032,
-0.009400103241205215,
0.011823269538581371,
-0.017375564202666283,
0.05054940655827522,
-0.013953874818980694,
0.00814082007855177,
-0.02423166111111641,
0.05245741084218025,
-0.016536042094230652,
0.011918669566512108,
0.0029701273888349533,
-0.013228832744061947,
0.006067455280572176,
-0.03467480465769768,
0.028213029727339745,
0.009966145269572735,
-0.036302968859672546,
0.025325583294034004,
-0.0048177121207118034,
0.050040606409311295,
-0.00944462325423956,
0.011664269492030144,
0.03874521702528,
0.03726969286799431,
0.031876400113105774,
0.04675883799791336,
-0.023201337084174156,
0.014259155839681625,
-0.004238950554281473,
0.003726969240233302,
0.024613261222839355,
0.013470513746142387,
-0.02550366334617138,
-0.04273930564522743,
-0.034903768450021744,
-0.0006666091503575444,
-0.01606540009379387,
-0.007651099003851414,
-0.00981986429542303,
-0.012777271680533886,
-0.0019143647514283657,
0.031164078041911125,
-0.000752071850001812,
-0.01437363587319851,
-0.0373205728828907,
-0.056731339544057846,
-0.03826185688376427,
-0.052355650812387466,
0.021255172789096832,
-0.007511178497225046,
0.013826674781739712,
0.03543800860643387,
-0.02387549914419651,
-0.03927945718169212,
-0.01881292648613453,
0.020860852673649788,
-0.005730374250560999,
-0.04836156219244003,
-0.016637802124023438,
-0.010112425312399864,
0.02479134127497673,
-0.016001800075173378,
0.00656989635899663,
0.028492871671915054,
-0.0031100476626306772,
-0.01774444431066513,
0.0158364400267601,
-0.019347168505191803,
0.0359468087553978,
-0.020695490762591362,
-0.003844629507511854,
0.0008959672413766384,
0.00905030220746994,
-0.027373507618904114,
-0.002151275286450982,
-0.043349869549274445,
-0.03233432024717331,
-0.03182552009820938,
-0.021445972844958305,
-0.012064949609339237,
0.009559104219079018,
-0.036506492644548416,
-0.017350122332572937,
0.007892780005931854,
-0.012637351639568806,
-0.015518439002335072,
-0.040958501398563385,
0.024473341181874275,
-0.00007974863547133282,
-0.03090967796742916,
0.00029236197588033974,
0.011346268467605114,
0.03126583620905876,
0.021585892885923386,
-0.003008287400007248,
-0.003860529512166977,
-0.004016350023448467,
0.023786459118127823,
-0.01803700439631939,
-0.010805667378008366,
-0.006684376858174801,
0.04945548251271248,
-0.006747976876795292,
-0.023404859006404877,
-0.043146345764398575,
-0.03085879608988762,
0.0014794986927881837,
0.022132854908704758,
0.019423488527536392,
0.043985869735479355,
0.020657330751419067,
0.0029526373837143183,
-0.011676989495754242,
0.010799307376146317,
-0.007135937921702862,
0.0027936368715018034,
-0.018126044422388077,
-0.00157569395378232,
0.013724913820624352,
-0.007829179055988789,
-0.00046587115502916276,
-0.022349094972014427,
-0.04411306977272034,
0.009781704284250736,
0.010036105290055275,
-0.025465503334999084,
-0.028899911791086197,
0.0050816526636481285,
0.05515405908226967,
0.040958501398563385,
-0.04953180253505707,
0.035259928554296494,
0.005587273743003607,
0.021814854815602303,
-0.004983072634786367,
-0.015658358111977577,
0.011015547439455986,
-0.0089803421869874,
-0.026991907507181168,
-0.016383400186896324,
-0.012630991637706757,
0.012879031710326672,
0.011727869510650635,
-0.045105233788490295,
0.0038287295028567314,
0.012694591656327248,
0.02198021486401558,
0.013635873794555664,
0.0013363983016461134,
-0.04551227390766144,
-0.03620120882987976,
0.04202698543667793,
-0.041594505310058594,
-0.027068227529525757,
0.024842221289873123,
0.006970577407628298,
-0.01559475902467966,
0.008350701071321964,
0.023544779047369957,
0.012739111669361591,
-0.016179880127310753,
-0.02120429277420044,
0.020822692662477493,
-0.004388411063700914,
-0.014042914845049381,
-0.004477451089769602,
0.01299987267702818,
-0.01724836230278015,
-0.025618143379688263,
-0.006900617387145758,
0.014882436953485012,
-0.005183412693440914,
0.031876400113105774,
-0.022310934960842133,
0.011467108502984047,
0.005431453697383404,
0.03436952456831932,
0.04917564243078232,
-0.025885265320539474,
0.026177825406193733,
-0.00429937057197094,
-0.008318901062011719,
-0.012281190603971481,
-0.014271875843405724,
0.007358538452535868,
0.014717076905071735,
0.0024772260803729296,
0.0067861368879675865,
0.06909520924091339,
0.020084930583834648,
0.009431903250515461,
-0.004633271601051092,
-0.027169987559318542,
0.009450983256101608,
-0.0030114674009382725,
-0.017172042280435562,
-0.003863709745928645,
0.03360632434487343,
-0.013445073738694191,
0.015900040045380592,
-0.023328538984060287,
-0.07754131406545639,
0.021891174837946892,
-0.01214763056486845,
-0.00974990427494049,
-0.011607028543949127,
0.013495953753590584,
-0.014131954871118069,
0.0024311160668730736,
-0.009253823198378086,
-0.012732751667499542,
-0.02344301901757717,
0.015378518030047417,
0.012707311660051346,
-0.007396698463708162,
-0.014958756975829601,
-0.014310035854578018,
-0.03034999594092369,
0.035895928740501404,
0.011918669566512108,
0.013559553772211075,
-0.025376463308930397,
0.003781029488891363,
-0.023048697039484978,
-0.01859668642282486,
-0.019677888602018356,
0.008147180080413818,
0.05054940655827522,
-0.008649621158838272,
-0.01640884019434452,
-0.020670050755143166,
-0.05199949070811272,
-0.028340229764580727,
-0.003402608446776867,
0.019614288583397865,
0.028162149712443352,
0.0012616681633517146,
-0.0022434955462813377,
-0.019970450550317764,
0.01535307802259922,
-0.014996916987001896,
0.008217140100896358,
0.046097394078969955,
0.0004114135226700455,
-0.007377618458122015,
0.04217962548136711,
-0.04118746146559715,
-0.00621691532433033,
0.005860754754394293,
0.0035838689655065536,
-0.015721959993243217,
-0.0007321968441829085,
-0.012274830602109432,
0.014106514863669872,
-0.0030003373976796865,
-0.022018374875187874,
-0.018189644441008568,
-0.02423166111111641,
0.029128871858119965,
-0.028874471783638,
-0.027551589533686638,
0.02471502125263214,
-0.022298214957118034,
0.038134656846523285,
0.04401130974292755,
0.01291719265282154,
0.007307658437639475,
-0.01803700439631939,
-0.003994090016931295,
0.010341385379433632,
-0.02021213062107563,
-0.027424387633800507,
-0.01036046538501978,
-0.047089558094739914,
0.011657909490168095,
0.0000041178618630510755,
-0.032715920358896255,
-0.015721959993243217,
-0.033911604434251785,
0.0065571763552725315,
0.0058416747488081455,
0.0016202140832319856,
-0.0010835876455530524,
0.025096623227000237,
0.029179751873016357,
0.012573751620948315,
-0.011925029568374157,
0.03050263598561287,
-0.02112797275185585,
-0.002461326075717807,
-0.004477451089769602,
-0.04960812255740166,
-0.0032531481701880693,
0.0076956190168857574,
-0.025885265320539474,
-0.009775344282388687,
-0.05240653082728386,
0.02839111164212227,
-0.006000674795359373,
-0.020937172695994377,
-0.009947064332664013,
0.005062572658061981,
-0.010290505364537239,
-0.0015470738289877772,
-0.0158491600304842,
0.029892073944211006,
-0.01345779374241829,
-0.04497803375124931,
0.0046873316168785095,
0.037295132875442505,
-0.03543800860643387,
0.024422461166977882,
-0.029688553884625435,
0.04421482980251312,
0.024104459211230278,
-0.11427676677703857,
-0.010856547392904758,
-0.0013761484296992421,
-0.005886194761842489,
-0.024524221196770668,
0.03085879608988762,
-0.0169049222022295,
-0.0028381571173667908,
0.016357960179448128,
-0.008929462172091007,
0.0009158423054032028,
0.002986027393490076,
0.015264037996530533,
-0.013826674781739712,
0.002817487111315131,
-0.011110947467386723,
-0.023328538984060287,
-0.03770217299461365,
0.004108570050448179,
0.031367599964141846,
0.005825774744153023,
0.019525248557329178,
0.0055968137457966805,
0.020873572677373886,
-0.004083130042999983,
0.01035410538315773,
-0.020084930583834648,
-0.028645511716604233,
-0.029535913839936256,
-0.009813504293560982,
0.003173647914081812,
0.017146602272987366,
-0.017719004303216934,
0.020759092643857002,
-0.013801234774291515,
-0.0380583330988884,
0.016803162172436714,
-0.023086857050657272,
0.04357882961630821,
-0.0016472440911456943,
0.01963972859084606,
-0.004706411622464657,
0.040958501398563385,
0.0016679142136126757,
-0.01028414536267519,
-0.012096750549972057,
-0.01887652650475502,
0.005536393728107214,
0.0323852002620697,
-0.02013581059873104,
0.043553389608860016,
-0.025020303204655647,
-0.021382372826337814,
0.01991957053542137,
-0.0005843264516443014,
-0.011893229559063911,
0.005813054274767637,
0.041111141443252563,
0.01656148210167885,
-0.012592831626534462,
-0.011575228534638882,
0.06909520924091339,
0.047852758318185806,
-0.020949892699718475,
-0.004960812162607908,
-0.028620071709156036,
-0.040678661316633224,
0.03816009685397148,
-0.027653349563479424,
0.004738211631774902,
-0.007250417955219746,
0.01261191163212061,
-0.024269821122288704,
0.027068227529525757,
-0.0006085740169510245,
0.007492098491638899,
0.020746372640132904,
-0.00009346241859020665,
0.003396248444914818,
0.012338430620729923,
-0.010404986329376698,
-0.016294360160827637,
-0.02704278752207756,
-0.027984069660305977,
-0.027169987559318542,
0.010258705355226994,
0.020084930583834648,
0.027373507618904114,
0.008496981114149094,
-0.003984550014138222,
-0.0316728800535202,
-0.00499897263944149,
0.0022371355444192886,
0.011861429549753666,
-0.011848709546029568,
-0.00830618105828762,
-0.039890021085739136,
-0.014437235891819,
-0.011804189532995224,
-0.010818387381732464,
0.050473086535930634,
-0.010099705308675766,
-0.005695394240319729,
-0.0549505352973938,
-0.019321728497743607,
-0.01733740232884884,
0.02274341695010662,
0.012459270656108856,
0.0003821972059085965,
-0.03541256859898567,
0.04604651406407356,
0.004585571587085724,
0.0068433769047260284,
-0.008357061073184013,
0.010557626374065876,
-0.0014325935626402497,
0.03726969286799431,
0.0007775119156576693,
-0.007523898966610432,
0.026788387447595596,
0.04106026142835617,
0.017986124381422997,
-0.0034280484542250633,
-0.016383400186896324,
-0.015823720023036003,
0.019334448501467705,
0.010729346424341202,
0.02627958543598652,
0.014157394878566265,
-0.009978865273296833,
-0.006474496331065893,
0.0018889247439801693,
0.002911297371610999,
0.013254272751510143,
-0.007091417443007231,
0.05149068683385849,
0.023214057087898254,
0.026508545503020287,
-0.020390210673213005,
0.02013581059873104,
0.00898670218884945,
-0.010335025377571583,
0.0218275748193264,
-0.03034999594092369,
0.03325016424059868,
-0.01475523691624403,
-0.061107032001018524,
0.04202698543667793,
-0.030044713988900185,
-0.002892217133194208,
-0.054187335073947906,
0.016739562153816223,
0.03386072441935539,
0.020759092643857002,
-0.019817808642983437,
0.018049724400043488,
0.01647244021296501,
-0.011460748501121998,
-0.011066427454352379,
0.004502891097217798,
-0.023621099069714546,
0.05156700685620308,
0.004397951066493988,
-0.01991957053542137,
0.022145574912428856,
-0.01592548005282879,
-0.011861429549753666,
0.011365348473191261,
0.04317178577184677,
0.04240858554840088,
0.016383400186896324,
-0.09422999620437622,
0.03403880447149277,
-0.006242355331778526,
-0.033199284225702286,
0.01475523691624403,
0.015264037996530533,
0.023989979177713394,
0.02592342533171177,
0.03991546109318733,
-0.02471502125263214,
-0.0028127171099185944,
0.05245741084218025,
0.04782731831073761,
0.01189958956092596,
0.0031354879029095173,
0.004003630019724369,
-0.024473341181874275,
0.01752820424735546,
0.012770911678671837,
-0.023086857050657272,
-0.01811332441866398,
0.02358293905854225,
0.03034999594092369,
0.018011564388871193,
-0.021636774763464928,
-0.03134215995669365,
-0.002415216062217951,
-0.04429114982485771,
-0.03607400879263878,
-0.02239997498691082,
0.028976231813430786,
0.04777643829584122,
-0.015861880034208298,
-0.020161250606179237,
0.010780226439237595,
0.01535307802259922,
-0.028340229764580727,
-0.021954774856567383,
0.0683320090174675,
0.014844276942312717,
0.024206221103668213,
-0.01944892853498459,
0.012630991637706757,
0.049557242542505264,
-0.0006363990833051503,
-0.003768309485167265,
-0.005987954791635275,
-0.013330592773854733,
0.007396698463708162,
-0.0373460128903389,
-0.016574202105402946,
-0.026305025443434715,
-0.0031593379098922014,
-0.008147180080413818,
-0.03393704444169998,
0.01838044635951519,
0.00442021107301116,
-0.0011877329088747501,
0.02958679385483265,
-0.015569319017231464,
0.007250417955219746,
0.01528947800397873,
0.012312990613281727,
-0.004404311068356037,
0.0013061882928013802,
-0.016103560104966164,
-0.03459848463535309,
0.004820892121642828,
-0.016319800168275833,
0.03604856878519058,
0.011823269538581371,
-0.0022466755472123623,
-0.013216112740337849,
-0.021356932818889618,
0.015022356994450092,
0.042993705719709396,
-0.020123090595006943,
-0.009177503176033497,
-0.007880060002207756,
-0.0207845326513052,
-0.0004296985571272671,
0.016167160123586655,
0.01598908007144928,
0.03645561262965202,
0.01521315798163414,
0.0037873894907534122,
0.02513478323817253,
0.03752409294247627,
0.015734679996967316,
-0.008178980089724064,
-0.01704484224319458,
0.028340229764580727,
0.0026187365874648094,
0.04897212237119675,
-0.018749326467514038,
-0.006646216381341219,
-0.031240398064255714,
0.0034057884477078915,
0.0053106131963431835,
0.010754786431789398,
0.008923102170228958,
0.01176602952182293,
0.005355133209377527,
-0.015950920060276985,
-0.025045743212103844,
0.0204283706843853,
-0.018075164407491684,
-0.009266543202102184,
0.02339213900268078,
-0.017655404284596443,
0.011403508484363556,
-0.02557998336851597,
0.008178980089724064,
0.012033149600028992,
-0.01397931482642889,
-0.012204870581626892,
-0.0067861368879675865,
0.009711744263768196,
-0.005107092671096325,
-0.04169626533985138,
-0.030451755970716476,
-0.02022485062479973,
-0.02541462332010269,
-0.0037651294842362404,
-0.009063022211194038,
0.006563536357134581,
-0.03760041296482086,
-0.011454388499259949,
-0.03220712020993233,
0.015149557963013649,
0.029637673869729042,
0.002194205531850457,
-0.047878198325634,
0.011575228534638882,
-0.022489016875624657,
-0.0007568419096060097,
-0.047445718199014664,
0.06400720030069351,
-0.008535141125321388,
-0.040754981338977814,
0.01873660646378994,
0.0019954550080001354,
-0.007892780005931854,
0.047852758318185806,
0.019181808456778526,
-0.028976231813430786,
0.029128871858119965,
0.00594979478046298,
0.024486061185598373,
-0.01881292648613453,
0.004318450577557087,
0.022094694897532463,
-0.00019706111925188452,
-0.032232560217380524,
-0.00024386685981880873,
-0.0005179438157938421,
-0.013025312684476376,
-0.0039018697571009398,
-0.023086857050657272,
0.02168765477836132,
-0.01858396641910076,
-0.008605101145803928,
0.024282541126012802,
0.001904824748635292,
0.004467911086976528,
0.0019382148748263717,
0.0016392940888181329,
0.011473468504846096,
0.01754092425107956,
-0.014780676923692226,
0.0067225368693470955,
0.007167737931013107,
-0.002111525274813175,
0.033631764352321625,
0.0012942631728947163,
0.011645189486443996,
-0.006194655317813158,
-0.023964539170265198,
-0.0033835284411907196,
0.04497803375124931,
0.009323783218860626,
-0.036379288882017136,
0.053983815014362335,
-0.0012322530383244157,
-0.005577733740210533,
-0.017311962321400642,
0.049404602497816086,
0.0017585443565621972,
-0.03607400879263878,
-0.015963640064001083,
0.029128871858119965,
0.04322266951203346,
-0.00238659605383873,
-0.009196583181619644,
0.03424232453107834,
-0.0380583330988884,
0.002550366334617138,
-0.01972876861691475,
0.01119998749345541,
0.026101505383849144,
0.010169665329158306,
-0.005409193690866232,
0.012491071596741676,
0.008369781076908112,
0.005987954791635275,
0.059987667948007584,
0.021535012871026993,
0.006194655317813158,
0.02260349690914154,
0.015747400000691414,
-0.01648516021668911,
-0.006983297411352396,
-0.02098805271089077,
-0.023544779047369957,
-0.01894012652337551,
-0.04050058126449585,
-0.0422559455037117,
0.026788387447595596,
-0.007377618458122015,
-0.02859463170170784,
-0.024524221196770668,
0.03826185688376427,
0.0030066973995417356,
-0.04401130974292755,
-0.008255300112068653,
-0.009959785267710686,
0.007504818495362997,
-0.0033167481888085604,
-0.0036188489757478237,
-0.040958501398563385,
-0.000484951218822971,
0.01999589055776596,
0.01130174845457077,
0.0002436681097606197,
0.012770911678671837,
0.010513106361031532,
0.027017347514629364,
0.013127072714269161,
0.02831478975713253,
-0.00506893265992403,
0.008541501127183437,
-0.039890021085739136,
0.0076383790001273155,
-0.023608379065990448,
-0.003924129996448755,
0.006671656854450703,
-0.00024784187553450465,
-0.029179751873016357,
-0.011556148529052734,
0.01320339273661375,
-0.01542939804494381,
-0.007422138471156359,
0.0017505943542346358,
0.005549113731831312,
0.00798818003386259,
0.03248696029186249,
0.011810549534857273,
-0.0380583330988884,
0.043833229690790176,
0.0029764873906970024,
-0.031011437997221947,
-0.010449506342411041,
-0.0027014168445020914,
-0.040398821234703064,
0.00748573848977685,
-0.004483811091631651,
0.007002377416938543,
-0.04548683390021324,
0.00974990427494049,
0.00845246110111475,
-0.01542939804494381,
0.04485082998871803,
0.025669023394584656,
-0.007829179055988789,
-0.020809972658753395,
-0.021942054852843285,
-0.011645189486443996,
0.03345368430018425,
0.023493899032473564,
0.02381189912557602,
0.024142621085047722,
-0.029256073758006096,
0.008853142149746418,
-0.03146935999393463,
-0.004439291078597307,
-0.024702301248908043,
-0.01654876209795475,
0.0053678532131016254,
0.0009897775016725063,
-0.05871566757559776,
-0.010875627398490906,
-0.0204283706843853,
0.03861801698803902,
0.008325261063873768,
-0.00005266888183541596,
-0.014882436953485012,
0.0072186179459095,
-0.009660864248871803,
-0.01228755060583353,
0.01620532013475895,
0.013317872770130634,
0.029917513951659203,
0.0062995958141982555,
-0.002467686077579856,
-0.010347745381295681,
0.040958501398563385,
0.011880509555339813,
0.028899911791086197,
-0.001604313962161541,
-0.005809874273836613,
0.02696646749973297,
-0.007123217917978764,
-0.0179606843739748,
0.005574553739279509,
-0.005975234787911177,
-0.00688153738155961,
-0.03439496457576752,
0.024524221196770668,
0.015582039020955563,
-0.021102532744407654,
0.007021457422524691,
-0.01914364844560623,
-0.022641656920313835,
-0.008401581086218357,
-0.0019731950014829636,
0.01197590958327055,
-0.02105165272951126,
0.004073590040206909,
0.013394193723797798,
-0.013584993779659271,
-0.022272774949669838,
0.01028414536267519,
-0.01457715593278408,
0.0051102726720273495,
0.010328665375709534,
-0.02246357686817646,
-0.07423410564661026,
-0.015582039020955563,
0.0158364400267601,
-0.02049197070300579,
0.006563536357134581,
-0.005332873202860355,
0.005262913182377815,
0.032639600336551666,
-0.013852114789187908,
-0.0084461010992527,
0.05698574334383011,
0.007460298482328653,
-0.008757742121815681,
0.017655404284596443,
0.009552744217216969,
0.017159322276711464,
-0.014335475862026215,
-0.023646539077162743,
-0.042942825704813004,
0.0010923327645286918,
0.022438134998083115,
-0.003930489998310804,
0.006868816912174225,
-0.002070185262709856,
-0.023570219054818153,
0.022807016968727112,
0.006697096861898899,
-0.011708789505064487,
0.04044970124959946,
0.0038128294982016087,
-0.0020892652682960033,
-0.0036220289766788483,
-0.010309585370123386,
-0.01648516021668911,
-0.0018269146094098687,
0.024206221103668213,
-0.000446791120339185,
0.012853591702878475,
0.02499486319720745,
0.01661236211657524,
-0.00499897263944149,
-0.02599974535405636,
-0.0013912534341216087,
0.006767056882381439,
0.0019143647514283657,
0.0023070957977324724,
0.019601568579673767,
-0.024778621271252632,
-0.047929078340530396,
-0.03050263598561287,
-0.002294375794008374,
-0.028696391731500626,
-0.005297893192619085,
0.04106026142835617,
0.015569319017231464,
0.02297237701714039,
0.01782076433300972,
0.008331621065735817,
0.0031831879168748856,
-0.015149557963013649,
-0.0119695495814085,
-0.03330104425549507,
-0.033199284225702286,
-0.00178716448135674,
0.010799307376146317,
-0.0007329918444156647,
0.010468586347997189,
0.009807144291698933,
0.031800080090761185,
-0.002722086850553751,
-0.0033294681925326586,
-0.00415309052914381,
0.004362971056252718,
-0.022590776905417442,
0.03816009685397148,
-0.0302736759185791,
0.020313890650868416,
-0.019677888602018356,
-0.02549094334244728,
-0.036302968859672546,
0.02035205066204071,
-0.018151484429836273,
0.016930362209677696,
-0.05108364671468735,
-0.0024120360612869263,
0.01461531687527895,
0.00859238114207983,
0.0048526921309530735,
0.013317872770130634,
0.023964539170265198,
0.01144166849553585,
-0.032283440232276917,
-0.011180907487869263,
-0.00929198320955038,
0.015225877985358238,
-0.008878582157194614,
-0.00779737951233983,
-0.011428948491811752,
-0.02083541266620159,
0.007765579503029585,
-0.03599768877029419,
-0.0026823366060853004,
-0.002294375794008374,
-0.010010665282607079,
-0.013228832744061947,
-0.023290378972887993,
-0.021255172789096832,
-0.015022356994450092,
0.008427021093666553,
-0.034471284598112106,
0.006404535844922066,
-0.0032658681739121675,
0.037727613002061844,
0.022985097020864487,
0.04037338122725487,
-0.01859668642282486,
0.016103560104966164,
-0.005739914253354073,
0.01980508863925934,
-0.017566364258527756,
-0.010118785314261913,
0.04332442954182625,
-0.03139303997159004,
0.004140370525419712,
0.04543595388531685,
0.016955802217125893,
-0.008070860058069229,
0.0067861368879675865,
-0.016218040138483047,
-0.004140370525419712,
0.0000026676043489715084,
-0.029408713802695274,
0.02028845064342022,
0.0005362288211472332,
0.027780549600720406,
0.01738828420639038,
0.0066144163720309734,
-0.021077092736959457,
0.014666196890175343,
-0.006274155806750059,
0.004954452160745859,
0.03190184012055397,
-0.019041886553168297,
-0.014551715925335884,
0.002467686077579856,
0.015276758000254631,
-0.007085057441145182,
0.026890147477388382,
0.00644269585609436,
-0.014335475862026215,
0.02105165272951126,
-0.027577029541134834,
0.0020908552687615156,
0.04401130974292755,
-0.020695490762591362,
0.01306347269564867,
-0.013228832744061947,
0.015060517936944962,
0.001981145003810525,
0.034471284598112106,
0.012325710617005825,
-0.02316317707300186,
-0.016230760142207146,
-0.03085879608988762,
0.00418807053938508,
-0.02775510959327221,
0.0027491168584674597,
0.09097366780042648,
0.003796929493546486,
0.014182834886014462,
0.005743094254285097,
0.00030647325911559165,
-0.026788387447595596,
0.006197835318744183,
-0.022641656920313835,
0.010328665375709534,
-0.007829179055988789,
-0.00898670218884945,
0.011422588489949703,
0.020097650587558746,
0.008007260039448738,
0.014195555821061134,
-0.00688153738155961,
0.00936830323189497,
0.01811332441866398,
-0.01867300644516945,
0.016510600224137306,
-0.008433381095528603,
0.0158364400267601,
-0.017362844198942184,
0.02072093077003956,
-0.014602595940232277,
-0.022081974893808365,
-0.006506296340376139,
0.00890402216464281,
0.013432353734970093,
-0.010633946396410465,
0.0007508793496526778,
0.0008792721782810986,
0.004588751588016748,
-0.032156240195035934,
0.0014103335561230779,
-0.023201337084174156,
-0.0037015292327851057,
-0.0002522143768146634,
0.02027573063969612,
0.014182834886014462,
0.02233637496829033,
0.021725814789533615,
0.029892073944211006,
0.024676861241459846,
0.018138764426112175,
0.016637802124023438,
-0.02494398131966591,
-0.018482206389307976,
0.02142053283751011,
-0.019970450550317764,
0.021178852766752243,
-0.01726108230650425,
0.0018936947453767061,
-0.02577078342437744,
-0.01559475902467966,
-0.0036601892206817865,
-0.0022021555341780186,
-0.005959334783256054,
-0.0074730184860527515,
-0.029892073944211006,
-0.04009354114532471,
0.00020451426098588854,
0.003542528720572591,
-0.0006093690171837807,
0.00943826325237751
] | 2025-01-15 | 52 | 39810257 | [
"CFR T cells",
"universal T cells",
"universal T cell therapy",
"xenograft mouse models",
"16s3 CFR T cells",
"The CFR T cells",
"the CFR T cells",
"specific MoAbs",
"specific target lysis experiments",
"mouse models",
"CFR",
"tumor xenograft destruction specificity",
"CAR) T cells",
"FcγR",
"chimeric Fcγ receptor (FcγR) T cells",
"different monoclonal antibodies",
"production analysis",
"MoAbs",
"degranulation assays",
"specificity",
"RTX",
"Several approaches",
"clinical trials",
"Chimeric FcγR (CFR) constructs",
"cytotoxicity",
"xenograft",
"CAR",
"CD32A",
"rituximab",
"CD20\nThe anti-tumor effects"
] | [
"Breast cancer",
"FcγR",
"Herceptin",
"Lymphoma",
"Off-the-shelf CAR T",
"Ovarian cancer",
"Rituximab",
"Universal CAR T"
] | 0 | 10.1186/s40164-025-00595-x | [
"Zhao",
"Chen",
"Li",
"Chen",
"Li",
"Guo",
"Wang",
"Jiang",
"Song",
"Wang",
"Liu"
] | [
"Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. [email protected].",
"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.",
"Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.",
"Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.\nTianjin Key Laboratory of Cell Therapy for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.",
"Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.",
"Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. [email protected].",
"State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China. [email protected].\nTianjin Key Laboratory of Cell Therapy for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. [email protected].\nNational Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China. [email protected].",
"Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.\nDepartment of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY, USA."
] | [
"39810257",
"21830940",
"36762851",
"38659046",
"37537626",
"39026380",
"39533415",
"38308374",
"35657079",
"35810754",
"35665782",
"32157732",
"34145037",
"35868279",
"32782358",
"34373452",
"34560415",
"31478910",
"26497522",
"26497516",
"2139735",
"2529342",
"32847974",
"26497510",
"11806974",
"12975461",
"27999754",
"30318772",
"24778321",
"16514054",
"24197131",
"37250170",
"37436890",
"36251156",
"34392305",
"31097020",
"32894185",
"35676488",
"32661364",
"37130030",
"36002574",
"33122343",
"20501798",
"37070661",
"31396956",
"19018092",
"18064051",
"38062252",
"20634814",
"35110735",
"37403182",
"35572525"
] | [] | 8.330652 | 4.810169 |
39809749 | 31 | Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells. | The excessive cytokine release and limited persistence represent major challenges for chimeric antigen receptor T (CAR-T) cell therapy in diverse tumors. Conventional CARs employ an intracellular domain (ICD) from the ζ subunit of CD3 as a signaling module, and it is largely unknown how alternative CD3 chains potentially contribute to CAR design. Here, we obtained a series of CAR-T cells against HER2 and mesothelin using a domain comprising a single immunoreceptor tyrosine-based activation motif from different CD3 subunits as the ICD of CARs. While these reconstituted CARs conferred sufficient antigen-specific cytolytic activity on equipped T cells, they elicited low tonic signal, ameliorated the exhaustion and promoted memory differentiation of these cells. Intriguingly, the CD3ε-derived ICD outperformed others in generation of CAR-T cells that produced minimized cytokines. Mechanistically, CD3ε-based CARs displayed a restrained cytomembrane expression on engineered T cells, which was ascribed to endoplasmic reticulum retention mediated by the carboxyl terminal basic residues. The present study demonstrated the applicability of CAR reconstitution using signaling modules from different CD3 subunits, and depicted a novel pattern of CAR expression that reduces cytokine release, thus paving a way for preparation of CAR-T cells displaying improved safety and persistence against diverse tumor antigens. | [
0.03684914484620094,
-0.008867732249200344,
0.023103252053260803,
0.05851373448967934,
-0.01638142764568329,
0.004805621691048145,
0.034044355154037476,
0.0022441346663981676,
-0.006836676970124245,
0.010554233565926552,
-0.005954135209321976,
-0.019295023754239082,
-0.019657712429761887,
0.005467528011649847,
0.026089387014508247,
-0.04942234233021736,
0.03554346412420273,
-0.01053005363792181,
0.005340586882084608,
0.025871774181723595,
0.0053133852779865265,
0.01482186745852232,
-0.033899277448654175,
0.018158599734306335,
-0.020951300859451294,
-0.0016275643138214946,
0.03752616420388222,
0.03486644849181175,
-0.0072356341406702995,
-0.0526139996945858,
0.023780271410942078,
-0.029692092910408974,
-0.02908761240541935,
-0.039702292531728745,
-0.013818428851664066,
0.04770561680197716,
0.02368355356156826,
0.013612905517220497,
-0.012524840421974659,
-0.02465072274208069,
0.04944652318954468,
0.034914806485176086,
0.024832068011164665,
0.05667611211538315,
-0.0725860446691513,
-0.01956099644303322,
-0.027370886877179146,
-0.010173410177230835,
0.0017529940232634544,
0.013129320926964283,
-0.037695419043302536,
0.009544750675559044,
-0.013564547523856163,
0.010554233565926552,
-0.06939438730478287,
0.016466055065393448,
-0.027056556195020676,
0.024578185752034187,
0.0016698780236765742,
0.019053231924772263,
0.002118704840540886,
-0.03235180675983429,
0.01494276337325573,
-0.009363406337797642,
-0.030224036425352097,
0.03392345830798149,
-0.03375420346856117,
-0.007562053855508566,
0.014483357779681683,
0.028023725375533104,
0.015849484130740166,
-0.03288375213742256,
0.005736521910876036,
0.003962371032685041,
0.031989119946956635,
-0.00707242451608181,
0.013661264441907406,
0.008523178286850452,
0.005410102196037769,
-0.016514413058757782,
0.03092523291707039,
0.00622010650113225,
0.008087951689958572,
-0.027056556195020676,
-0.0009006762411445379,
-0.02645207569003105,
0.03510823845863342,
-0.06833049654960632,
-0.003515055403113365,
-0.014072311110794544,
-0.027201632037758827,
0.005736521910876036,
-0.04806830734014511,
0.02248668298125267,
-0.01813442073762417,
0.03513241931796074,
-0.03138463944196701,
-0.05406475439667702,
0.009206240996718407,
0.01393932569772005,
0.038420792669057846,
-0.007283992599695921,
-0.023562658578157425,
0.016308888792991638,
-0.007326306309551001,
0.019125768914818764,
-0.04516679793596268,
0.005857418291270733,
0.0008016925421543419,
-0.01662321947515011,
0.10164947807788849,
-0.002649136818945408,
-0.019113680347800255,
0.055418793112039566,
-0.018315766006708145,
-0.05624088644981384,
-0.025557445362210274,
0.018871888518333435,
-0.024300124496221542,
0.02679058536887169,
0.004149760119616985,
0.02026219293475151,
0.05919075012207031,
0.019016962498426437,
-0.008740791119635105,
-0.027927009388804436,
0.05923910811543465,
-0.02225697971880436,
-0.055902376770973206,
-0.04323245957493782,
0.07282783836126328,
0.0038021837826818228,
0.0303691104054451,
0.0054040574468672276,
-0.045988891273736954,
-0.00021761305106338114,
-0.01303260400891304,
-0.022535040974617004,
-0.07306963205337524,
-0.034527938812971115,
0.00230609392747283,
-0.033899277448654175,
-0.011110355146229267,
-0.01613963581621647,
-0.01291170809417963,
-0.023030715063214302,
-0.006510257255285978,
0.006419585086405277,
0.005255959928035736,
0.047633081674575806,
-0.011757150292396545,
0.050341155380010605,
0.050099361687898636,
-0.026814764365553856,
-0.014531716704368591,
-0.05038951337337494,
-0.00889795646071434,
0.005812081973999739,
-0.008015414699912071,
-0.04098379239439964,
0.007271903101354837,
0.010638860985636711,
-0.06789527088403702,
-0.007374664768576622,
0.0032672183588147163,
-0.007477426435798407,
-0.008813329041004181,
0.04030677303671837,
-0.08549775183200836,
-0.02724999003112316,
-0.001519513432867825,
-0.04951905831694603,
-0.05952925980091095,
-0.023381313309073448,
-0.06765348464250565,
-0.006552570965141058,
0.0057425666600465775,
0.03972647339105606,
-0.019839057698845863,
0.007187275681644678,
0.022389965131878853,
0.011225206777453423,
0.02280101180076599,
0.013516188599169254,
-0.019972043111920357,
0.02034682035446167,
-0.024517737329006195,
0.0022411122918128967,
-0.03382674232125282,
0.02218444272875786,
-0.01652650348842144,
0.015027390792965889,
0.06678302586078644,
0.019113680347800255,
-0.013927235268056393,
-0.017977256327867508,
0.030852695927023888,
0.023719822987914085,
0.009762363508343697,
-0.019125768914818764,
0.03162642940878868,
0.006256375461816788,
-0.013516188599169254,
-0.008124221116304398,
-0.01442290935665369,
0.01732441782951355,
-0.015112018212676048,
0.01842457242310047,
-0.03058672323822975,
-0.004720994271337986,
0.04228946939110756,
-0.026282820850610733,
-0.01049378514289856,
0.016030829399824142,
-0.02526729367673397,
-0.029498659074306488,
0.02075786702334881,
0.040258415043354034,
-0.003197703044861555,
0.002201820956543088,
-0.015595602802932262,
0.011442819610238075,
-0.0042192754335701466,
-0.0005753900622949004,
-0.06136688217520714,
-0.0007231100462377071,
-0.01780800148844719,
-0.032859571278095245,
0.007241678889840841,
-0.0029785786755383015,
-0.009605198167264462,
0.020612793043255806,
0.02002040110528469,
-0.045577846467494965,
-0.022462503984570503,
0.026427896693348885,
0.023272506892681122,
-0.010197589173913002,
0.06262420117855072,
-0.041830066591501236,
0.0013797272695228457,
0.03225509077310562,
0.023260418325662613,
-0.006153613794595003,
-0.014217386022210121,
-0.026016850024461746,
-0.017602479085326195,
-0.055031925439834595,
-0.019452190026640892,
-0.026331180706620216,
0.012669915333390236,
0.015220824629068375,
-0.009986021555960178,
-0.014048132114112377,
0.009508481249213219,
0.06160867586731911,
0.0363655611872673,
-0.004923495464026928,
0.006667422130703926,
-0.014108579605817795,
-0.01994786411523819,
0.011902225203812122,
-0.0031916580628603697,
-0.008100041188299656,
-0.03672824800014496,
0.024348482489585876,
0.014410819858312607,
0.023332955315709114,
0.017687106505036354,
-0.022668026387691498,
0.04369186609983444,
-0.01549888588488102,
0.023502210155129433,
0.03798556700348854,
-0.05585401877760887,
0.012657825835049152,
-0.004439910873770714,
0.03767123818397522,
0.014277834445238113,
0.03203747794032097,
-0.013250216841697693,
0.002703540027141571,
-0.010088782757520676,
-0.005119951441884041,
-0.021725036203861237,
-0.019899504259228706,
0.00006082587060518563,
-0.027056556195020676,
0.023079073056578636,
-0.055031925439834595,
0.026597151532769203,
-0.02218444272875786,
-0.04949488118290901,
-0.03535003215074539,
-0.04497336596250534,
0.024904605001211166,
-0.03648645430803299,
-0.03218255192041397,
-0.039387963712215424,
0.015402168966829777,
-0.04770561680197716,
0.013745891861617565,
-0.00985303521156311,
-0.029619554057717323,
-0.012367675080895424,
-0.011080131866037846,
0.016562771052122116,
-0.03919452801346779,
0.062430769205093384,
0.038590047508478165,
0.0473429299890995,
-0.02122936211526394,
0.006945483386516571,
0.038275718688964844,
-0.006274509709328413,
-0.03305300697684288,
0.0014741773484274745,
-0.04966413602232933,
0.028192980214953423,
-0.05406475439667702,
-0.0347939096391201,
0.002136839320883155,
-0.028168801218271255,
0.01355245802551508,
0.02575087919831276,
0.006075031124055386,
-0.010282216593623161,
-0.035325851291418076,
0.004899316001683474,
-0.04076617956161499,
0.029764629900455475,
-0.021422795951366425,
0.08249952644109726,
-0.025605803355574608,
0.018956515938043594,
-0.028507310897111893,
-0.05445162206888199,
-0.008801239542663097,
0.031021950766444206,
0.03571271896362305,
-0.0028818617574870586,
0.051695190370082855,
-0.01963353343307972,
0.0387834832072258,
-0.004727039020508528,
0.003968415781855583,
-0.00508368294686079,
0.004364350810647011,
0.016792474314570427,
0.003273263107985258,
0.002271336270496249,
0.00098379235714674,
-0.003690354758873582,
-0.046375758945941925,
0.03353659063577652,
0.03943632170557976,
-0.01818278059363365,
-0.009520571678876877,
0.003164456458762288,
-0.0016139635117724538,
0.043039027601480484,
0.027757754549384117,
-0.021023839712142944,
0.03281121328473091,
0.04195095971226692,
0.06378480792045593,
-0.01256110891699791,
0.05087309703230858,
-0.01168461237102747,
-0.03107030875980854,
-0.008734745904803276,
-0.026572972536087036,
0.006510257255285978,
0.007731308229267597,
0.0033125542104244232,
0.01715516299009323,
0.04567456245422363,
0.036607351154088974,
0.022389965131878853,
-0.03218255192041397,
0.050099361687898636,
-0.03406853228807449,
0.015909932553768158,
-0.04117722436785698,
0.005911821499466896,
-0.008142354898154736,
0.008269296027719975,
-0.011213117279112339,
-0.0831281840801239,
0.06494540721178055,
-0.018533378839492798,
-0.01930711418390274,
0.005573312286287546,
-0.019246665760874748,
-0.02232951670885086,
0.04461067542433739,
-0.02041935920715332,
0.04436888545751572,
0.05174354836344719,
0.031747326254844666,
-0.0035090106539428234,
0.023719822987914085,
-0.039533037692308426,
-0.0417817085981369,
0.02399788424372673,
0.003835430135950446,
0.056772828102111816,
0.0012270958395674825,
0.005346632096916437,
-0.041757527738809586,
0.018883977085351944,
0.006697646342217922,
0.032448526471853256,
0.030296573415398598,
-0.00921833049505949,
-0.05188862606883049,
-0.03781631216406822,
0.031094487756490707,
0.038348257541656494,
0.029281046241521835,
0.023248327895998955,
-0.04552948847413063,
0.00741093372926116,
-0.04782651364803314,
0.01061468105763197,
0.01256110891699791,
0.01859382726252079,
0.007670860271900892,
0.015704408288002014,
-0.06557406485080719,
-0.037236012518405914,
0.06054478883743286,
-0.012863349169492722,
-0.009321092627942562,
-0.0029725339263677597,
0.025339830666780472,
0.004757263232022524,
0.023744001984596252,
-0.06078657880425453,
0.04436888545751572,
0.0062624202109873295,
0.009756318293511868,
-0.008009369485080242,
-0.04504590108990669,
0.0556122250854969,
0.025557445362210274,
0.013322754763066769,
-0.024130869656801224,
-0.022389965131878853,
0.02645207569003105,
-0.06006120517849922,
-0.034141071140766144,
-0.0357852578163147,
0.042071856558322906,
-0.01291170809417963,
-0.013298575766384602,
0.06494540721178055,
-0.020721599459648132,
-0.023550568148493767,
0.01053005363792181,
0.03568854182958603,
-0.025243114680051804,
0.02717745304107666,
0.0036601307801902294,
-0.029933884739875793,
0.03399599716067314,
0.024336393922567368,
-0.031336281448602676,
0.011080131866037846,
-0.047657258808612823,
0.000638860568869859,
-0.011394461616873741,
-0.017687106505036354,
0.026427896693348885,
-0.007423023227602243,
0.02964373491704464,
0.030006421729922295,
0.010729532688856125,
0.023151611909270287,
0.0018874909728765488,
-0.013250216841697693,
-0.01564396172761917,
-0.03486644849181175,
0.004702860023826361,
0.02790283039212227,
0.06305942684412003,
-0.03312554210424423,
-0.03058672323822975,
0.002945332322269678,
0.027467602863907814,
0.02312743291258812,
-0.007592277601361275,
0.02592013217508793,
-0.011134535074234009,
0.002123238518834114,
0.0065646604634821415,
0.0166111309081316,
-0.025339830666780472,
-0.049905925989151,
0.024130869656801224,
0.010638860985636711,
0.02756432071328163,
0.0019358494319021702,
0.009339227341115475,
0.029111791402101517,
0.049712494015693665,
-0.005917866248637438,
0.034600477665662766,
0.006144546438008547,
0.013782160356640816,
-0.02478371001780033,
-0.03394763544201851,
0.055418793112039566,
-0.004983943421393633,
-0.029764629900455475,
-0.044223807752132416,
-0.028410593047738075,
-0.002865238580852747,
-0.010433336719870567,
-0.002677849493920803,
-0.024977143853902817,
-0.049712494015693665,
0.011376326903700829,
0.019887415692210197,
0.0186059158295393,
-0.02693566121160984,
-0.036051228642463684,
-0.04615814611315727,
-0.027757754549384117,
-0.03839661553502083,
0.041926782578229904,
-0.021833842620253563,
0.03854168951511383,
0.017215611413121223,
-0.006377271376550198,
-0.02050398662686348,
-0.013733801431953907,
0.05179190635681152,
0.008885866031050682,
-0.04681098461151123,
0.021350258961319923,
-0.012524840421974659,
0.01117080356925726,
0.005355698987841606,
0.002529751742258668,
0.030417470261454582,
-0.011388416402041912,
-0.029667913913726807,
0.037550341337919235,
0.018219048157334328,
0.02613774687051773,
-0.037090934813022614,
0.01370962243527174,
-0.03058672323822975,
-0.00238316529430449,
-0.03634138032793999,
0.011587895452976227,
-0.03128792345523834,
-0.019415920600295067,
0.010088782757520676,
-0.03987154737114906,
-0.004893271252512932,
-0.013818428851664066,
-0.009417809545993805,
-0.026041029021143913,
-0.010088782757520676,
0.0007476671016775072,
0.004829800687730312,
-0.05300086736679077,
0.04903547465801239,
0.0003668442368507385,
-0.013721711933612823,
0.020153386518359184,
-0.011920359916985035,
0.041201405227184296,
0.01986323669552803,
-0.02017756551504135,
0.0207457784563303,
-0.0036057273391634226,
0.007525784894824028,
-0.011158714070916176,
-0.02128981053829193,
0.008601760491728783,
0.0583202987909317,
-0.030490007251501083,
0.031021950766444206,
-0.03138463944196701,
-0.04151573404669762,
-0.00015452038496732712,
0.015583512373268604,
0.011182893067598343,
0.014700970612466335,
0.02741924487054348,
0.023006536066532135,
-0.03186822310090065,
0.02255921997129917,
0.013854698278009892,
-0.002783633768558502,
-0.03900109604001045,
0.007477426435798407,
0.031046129763126373,
0.012452302500605583,
-0.020310552790760994,
-0.05309758707880974,
-0.030973590910434723,
0.02654879353940487,
0.008456685580313206,
-0.010796025395393372,
-0.03677660599350929,
0.019573085010051727,
0.05382296442985535,
0.0441996306180954,
-0.009393630549311638,
0.017058445140719414,
-0.0010321508161723614,
0.008952359668910503,
-0.01605500839650631,
-0.02780611254274845,
0.0027443424332886934,
-0.005996448453515768,
-0.02423967607319355,
-0.009109524078667164,
-0.01629680022597313,
0.008982582949101925,
0.00043522610212676227,
-0.020080849528312683,
-0.00968982558697462,
-0.010445427149534225,
0.01708262413740158,
0.002224489115178585,
-0.016562771052122116,
-0.013322754763066769,
-0.02385280840098858,
0.02415504865348339,
-0.0037175563629716635,
-0.02884581871330738,
0.018847709521651268,
0.006138501688838005,
-0.012682005763053894,
0.02311534248292446,
-0.020443538203835487,
0.01916203834116459,
-0.017505761235952377,
-0.030949411913752556,
0.03597869351506233,
0.01947636902332306,
-0.0039049454499036074,
0.020552344620227814,
0.004893271252512932,
-0.0014031508471816778,
-0.019331293180584908,
-0.006461898796260357,
0.03856587037444115,
-0.0016351203666999936,
0.025364011526107788,
-0.007858249358832836,
0.019887415692210197,
-0.0009611243149265647,
0.042942311614751816,
0.03670406714081764,
-0.040645282715559006,
0.02249877154827118,
-0.02305489405989647,
-0.029039252549409866,
-0.012645736336708069,
0.0018769126618281007,
-0.008529222570359707,
-0.007211454678326845,
-0.012633646838366985,
-0.00822093803435564,
0.07659979909658432,
0.014023952186107635,
0.00508368294686079,
-0.009840945713222027,
0.002868260955438018,
0.023381313309073448,
-0.0014227965148165822,
-0.004385507665574551,
-0.02606520801782608,
-0.006981752347201109,
-0.002893951488658786,
0.027999546378850937,
-0.015317541547119617,
-0.05585401877760887,
0.01635724864900112,
-0.009254599921405315,
0.003950281534343958,
0.0076043675653636456,
-0.016248442232608795,
-0.010137141682207584,
-0.002807812998071313,
-0.0008001813548617065,
-0.022365786135196686,
-0.011182893067598343,
0.00109864363912493,
0.02002040110528469,
0.011618119664490223,
-0.0390736348927021,
-0.007580188103020191,
0.00778571143746376,
0.029450301080942154,
-0.003104008501395583,
-0.0010064603993669152,
-0.00826325174421072,
0.02162832021713257,
-0.03597869351506233,
-0.006334957666695118,
-0.009157883003354073,
0.013842608779668808,
0.031916581094264984,
0.004334126599133015,
-0.011992896907031536,
-0.011176848784089088,
-0.016006648540496826,
0.0003101741604041308,
-0.0033095318358391523,
0.01755411922931671,
0.05604745075106621,
0.013516188599169254,
0.021156825125217438,
0.004028863739222288,
0.012935887090861797,
-0.038420792669057846,
-0.005092749837785959,
0.032956287264823914,
0.007682949770241976,
-0.02400997467339039,
0.03447958081960678,
-0.021035928279161453,
-0.0076889945194125175,
-0.01820695959031582,
-0.014205296523869038,
-0.03638973832130432,
0.010239902883768082,
-0.031819865107536316,
0.027612678706645966,
-0.02519475668668747,
-0.024517737329006195,
0.0036299065686762333,
-0.012095659039914608,
0.03617212548851967,
-0.0333673357963562,
-0.0060508521273732185,
0.012416034005582333,
-0.019899504259228706,
0.042386189103126526,
0.03868676722049713,
0.0020234992261976004,
0.029909705743193626,
-0.03571271896362305,
-0.00001739062645356171,
0.009036987088620663,
-0.02645207569003105,
0.0032521062530577183,
-0.006256375461816788,
-0.02724999003112316,
-0.016224263235926628,
-0.01506365928798914,
-0.009381541050970554,
-0.015559333376586437,
0.004678680561482906,
-0.0031493445858359337,
-0.012585288845002651,
0.030876874923706055,
-0.015087838284671307,
0.013431561179459095,
-0.010638860985636711,
0.015692319720983505,
-0.010747667402029037,
0.04574710130691528,
0.0007797800935804844,
-0.016804564744234085,
-0.00024405909061897546,
0.001769617316313088,
0.015583512373268604,
0.0008508065948262811,
-0.008021458983421326,
0.001600362709723413,
-0.011188938282430172,
0.009756318293511868,
-0.008184668608009815,
0.009949752129614353,
-0.016562771052122116,
0.013226037845015526,
-0.002807812998071313,
-0.025218935683369637,
-0.026645509526133537,
0.002281914697960019,
0.015039480291306973,
-0.020407268777489662,
-0.024614455178380013,
0.031336281448602676,
-0.032472703605890274,
0.036510635167360306,
-0.00359666021540761,
0.03554346412420273,
0.01931920275092125,
-0.07930786907672882,
-0.05053458735346794,
-0.004974876064807177,
-0.025460727512836456,
-0.0045819636434316635,
0.01024594809859991,
-0.01442290935665369,
-0.0062865992076694965,
-0.01565605029463768,
-0.006643243134021759,
-0.010306396521627903,
0.003363935276865959,
0.04161245375871658,
0.015196644701063633,
0.013431561179459095,
-0.014797687530517578,
-0.021870112046599388,
-0.043353356420993805,
-0.004811666440218687,
0.045892175287008286,
0.002183686476200819,
0.005431259050965309,
0.009091390296816826,
0.035011522471904755,
0.0008024481358006597,
-0.014833956956863403,
-0.01605500839650631,
-0.004092334304004908,
-0.06006120517849922,
-0.02964373491704464,
0.011334013193845749,
-0.011370282620191574,
-0.009520571678876877,
0.03211001679301262,
-0.032448526471853256,
-0.03252106159925461,
0.03515659645199776,
-0.025799237191677094,
-0.010318486019968987,
0.014132759533822536,
0.0402100570499897,
0.0008409838192164898,
-0.007005931343883276,
0.0015134685672819614,
-0.025170577690005302,
-0.03312554210424423,
-0.012960066087543964,
0.007078469265252352,
-0.007894517853856087,
-0.011648342944681644,
0.0263069998472929,
-0.01621217280626297,
-0.03670406714081764,
0.03962975740432739,
-0.0069333938881754875,
-0.011890135705471039,
0.0017091692425310612,
0.044223807752132416,
-0.0009407231118530035,
-0.013383203186094761,
-0.013262307271361351,
0.025001322850584984,
0.004140692763030529,
0.000026021005396614783,
0.0012663870584219694,
-0.0333673357963562,
-0.026041029021143913,
0.010971324518322945,
-0.010378933511674404,
0.002204843331128359,
-0.012549019418656826,
0.009568929672241211,
-0.04901129752397537,
0.020044580101966858,
-0.010076693259179592,
0.012802901677787304,
-0.032061658799648285,
0.00786429364234209,
-0.001017794362269342,
0.0117631945759058,
-0.02027428336441517,
-0.04659337177872658,
0.005334542132914066,
-0.011412596330046654,
-0.028990894556045532,
-0.029740450903773308,
-0.03597869351506233,
0.015668140724301338,
-0.008009369485080242,
-0.008801239542663097,
-0.006407495588064194,
-0.00609921058639884,
-0.009883259423077106,
-0.003110053250566125,
-0.0023589860647916794,
-0.011370282620191574,
-0.04011334106326103,
0.0015792058547958732,
0.0036782650277018547,
-0.01315349992364645,
0.05464505776762962,
-0.017904719337821007,
-0.004893271252512932,
-0.03987154737114906,
-0.03520495817065239,
-0.008432505652308464,
0.030949411913752556,
-0.024433109909296036,
0.025170577690005302,
-0.00842041615396738,
0.01963353343307972,
0.012682005763053894,
0.008607805706560612,
-0.01588575355708599,
0.00261286785826087,
0.026089387014508247,
0.041201405227184296,
-0.01842457242310047,
0.012391855008900166,
-0.003968415781855583,
0.04028259590268135,
-0.001171181327663362,
0.0018844685982912779,
-0.015776947140693665,
0.0114790890365839,
0.03600287064909935,
0.003369980026036501,
0.03324643895030022,
0.009834901429712772,
-0.018799349665641785,
0.004926517605781555,
-0.004370395559817553,
0.003533189883455634,
-0.0009452567319385707,
-0.00719332043081522,
0.03554346412420273,
0.014785598032176495,
0.029547017067670822,
-0.0018255317118018866,
0.016865011304616928,
-0.004509426187723875,
0.004192073829472065,
0.010578412562608719,
-0.02613774687051773,
0.017542030662298203,
-0.01869054324924946,
-0.0610283724963665,
0.02170085720717907,
-0.01812233217060566,
0.016901280730962753,
-0.026282820850610733,
0.03885602205991745,
0.035567644983530045,
0.02582341618835926,
0.010681173764169216,
0.03276285529136658,
0.036607351154088974,
-0.021507423371076584,
0.01100154872983694,
0.03123956359922886,
-0.018497109413146973,
0.0551769994199276,
-0.013093052431941032,
-0.01723979040980339,
0.016732025891542435,
-0.028168801218271255,
-0.015958290547132492,
-0.009520571678876877,
0.000986059196293354,
0.019355472177267075,
0.005697230808436871,
-0.09275151789188385,
0.036510635167360306,
0.004225320182740688,
-0.034527938812971115,
-0.01659904047846794,
0.030175676569342613,
0.022039366886019707,
0.030296573415398598,
0.03917035087943077,
-0.036220483481884,
-0.003965393640100956,
0.008517133072018623,
0.024904605001211166,
-0.001870867796242237,
-0.012899618595838547,
0.0017681061290204525,
-0.03169896826148033,
0.03537421301007271,
-0.001564093865454197,
-0.013733801431953907,
-0.026500433683395386,
-0.015015301294624805,
0.026186104863882065,
0.015583512373268604,
-0.009810722433030605,
-0.03162642940878868,
-0.005449393764138222,
-0.02870074473321438,
-0.023465940728783607,
-0.04937398433685303,
0.022825192660093307,
0.03694586083292961,
-0.019839057698845863,
-0.019972043111920357,
-0.0045819636434316635,
0.012452302500605583,
-0.02200309745967388,
0.012742453254759312,
0.03648645430803299,
0.011654388159513474,
0.045021723955869675,
0.012524840421974659,
0.025702519342303276,
0.03416524827480316,
0.011273565702140331,
0.0055158864706754684,
-0.0345037579536438,
-0.023006536066532135,
-0.0013230571057647467,
-0.023719822987914085,
-0.026984019204974174,
-0.0012981223408132792,
-0.010348710231482983,
-0.005561222787946463,
-0.003442517714574933,
0.009707960300147533,
0.024590276181697845,
-0.011624163947999477,
0.018001435324549675,
-0.019029052928090096,
0.03172314912080765,
-0.005929955746978521,
-0.021555781364440918,
0.010348710231482983,
-0.005144130904227495,
-0.0021277721971273422,
-0.02089085429906845,
0.01092296652495861,
-0.004270656034350395,
0.054306548088788986,
0.04093543440103531,
-0.005775813013315201,
-0.027298349887132645,
-0.021894291043281555,
-0.009871169924736023,
0.046061430126428604,
-0.019609354436397552,
-0.0048751370050013065,
-0.0015361366095021367,
-0.015631871297955513,
0.023635195568203926,
0.03975065052509308,
0.020866673439741135,
0.05648267641663551,
0.020068759098649025,
0.009629378095269203,
0.030078960582613945,
0.040185876190662384,
0.005567267537117004,
0.014374551363289356,
-0.0008372057927772403,
0.0042041633278131485,
-0.018799349665641785,
0.008172579109668732,
-0.004850957542657852,
-0.009151837788522243,
-0.001017794362269342,
0.0028879065066576004,
0.0262344628572464,
0.03566436097025871,
0.019270844757556915,
0.00707242451608181,
0.01426574494689703,
0.023949526250362396,
-0.016707846894860268,
0.025146396830677986,
0.0004971853923052549,
-0.008565491996705532,
-0.00592391099780798,
-0.008577581495046616,
-0.022196531295776367,
-0.03211001679301262,
0.00885564275085926,
0.030393289402127266,
0.001064641634002328,
-0.014193207025527954,
0.0015240469947457314,
0.032375987619161606,
-0.022522950544953346,
-0.023635195568203926,
-0.035011522471904755,
-0.019246665760874748,
-0.034938983619213104,
-0.011823642998933792,
-0.023623107001185417,
0.005951112601906061,
-0.016345158219337463,
0.00639540608972311,
-0.01765083707869053,
-0.006794363260269165,
0.019174128770828247,
0.005410102196037769,
-0.02297026664018631,
0.02162832021713257,
-0.010270127095282078,
-0.000944501138292253,
-0.02408251166343689,
0.05508028343319893,
-0.007211454678326845,
-0.021749215200543404,
0.024058332666754723,
0.016248442232608795,
-0.0028969738632440567,
0.02749178372323513,
0.03462465479969978,
-0.032956287264823914,
0.012585288845002651,
0.0028486154042184353,
0.027370886877179146,
-0.027395065873861313,
0.02369564399123192,
0.015317541547119617,
-0.005588424392044544,
-0.03680078685283661,
-0.005425214301794767,
0.007592277601361275,
-0.02168876864016056,
0.020528165623545647,
-0.0027987456414848566,
0.013346933759748936,
-0.0208183154463768,
0.01659904047846794,
-0.003539234632626176,
-0.02113264612853527,
-0.002933242591097951,
0.005712342914193869,
0.000002204819793405477,
0.01638142764568329,
0.009828856214880943,
-0.011315879411995411,
0.0022728475742042065,
-0.0051018171943724155,
0.0022214665077626705,
0.017542030662298203,
0.0066553326323628426,
0.019029052928090096,
-0.00862593948841095,
-0.027153274044394493,
-0.024529827758669853,
0.049615778028964996,
-0.017022177577018738,
-0.026282820850610733,
0.0526139996945858,
0.02137443795800209,
0.0017318372847512364,
-0.018618006259202957,
0.05358117073774338,
-0.009315047413110733,
-0.013890966773033142,
-0.0053194304928183556,
0.03909781202673912,
0.04190260171890259,
0.009834901429712772,
-0.023248327895998955,
0.012887529097497463,
-0.04386112093925476,
0.00901885237544775,
0.0010291284415870905,
0.03360912948846817,
0.007060334552079439,
0.0041286032646894455,
-0.0008039593230932951,
0.008740791119635105,
-0.002768521662801504,
-0.0014522649580612779,
0.031819865107536316,
0.004760285839438438,
0.008148400112986565,
0.043280817568302155,
-0.0000018299708699487383,
-0.017421133816242218,
-0.00571838766336441,
-0.024832068011164665,
-0.009998111054301262,
-0.00968982558697462,
-0.04132230207324028,
-0.03551928699016571,
-0.008087951689958572,
-0.028313877061009407,
-0.011938493698835373,
-0.029111791402101517,
0.020709509029984474,
0.011321923695504665,
-0.03585779666900635,
-0.02780611254274845,
-0.00021591295080725104,
0.026814764365553856,
0.0023665418848395348,
0.01024594809859991,
-0.04216857627034187,
-0.013322754763066769,
0.028434772044420242,
-0.019923685118556023,
-0.004999055527150631,
0.023719822987914085,
0.01979069784283638,
0.034914806485176086,
-0.015946201980113983,
-0.010052514262497425,
-0.010717443190515041,
-0.004385507665574551,
-0.05730477347970009,
0.014289923943579197,
-0.040500208735466,
-0.004306924995034933,
0.003005780279636383,
-0.03211001679301262,
-0.011593939736485481,
-0.010499830357730389,
-0.006461898796260357,
-0.0053798784501850605,
-0.011213117279112339,
-0.010131096467375755,
-0.00013723601296078414,
-0.007701084483414888,
0.017143072560429573,
0.003750802716240287,
-0.04461067542433739,
0.030417470261454582,
0.020238013938069344,
-0.0019071366405114532,
-0.0018663342343643308,
-0.01818278059363365,
-0.040572743862867355,
0.03235180675983429,
0.006830632220953703,
0.026887301355600357,
0.007453246973454952,
0.011787373572587967,
0.00842041615396738,
0.0017439268995076418,
0.028265519067645073,
0.03832407668232918,
0.021664589643478394,
-0.015776947140693665,
0.0032521062530577183,
-0.0009414787054993212,
0.018956515938043594,
0.040500208735466,
0.024022063240408897,
0.01109222136437893,
-0.0029831123538315296,
-0.023647285997867584,
-0.044852469116449356,
-0.0031191203743219376,
-0.0262344628572464,
-0.03815482184290886,
-0.006280554458498955,
0.013346933759748936,
-0.030731799080967903,
-0.0014507536543533206,
-0.008480864576995373,
0.04424798861145973,
-0.012258868664503098,
-0.019839057698845863,
-0.019186217337846756,
-0.03160225227475166,
-0.023490119725465775,
-0.02462654374539852,
0.016985908150672913,
0.01580112613737583,
0.03201329708099365,
0.00488722650334239,
0.03648645430803299,
-0.013806339353322983,
0.028072085231542587,
0.016562771052122116,
0.014084400609135628,
-0.015136197209358215,
-0.037622880190610886,
-0.000493029598146677,
0.004107446409761906,
-0.008589670993387699,
0.005195511505007744,
0.02867656573653221,
0.01346783060580492,
-0.02932940423488617,
0.021821754053235054,
-0.0012014054227620363,
-0.000749556056689471,
-0.019597264006733894,
-0.026597151532769203,
-0.0036963995080441236,
-0.011176848784089088,
-0.0028199024964123964,
0.013987683691084385,
-0.002615890232846141,
-0.0158978421241045,
-0.023864898830652237,
-0.006534436717629433,
-0.011878046207129955,
0.009804677218198776,
-0.040741998702287674,
-0.017675016075372696,
-0.020225925371050835,
-0.054161470383405685,
-0.037622880190610886,
0.0066553326323628426,
0.010040424764156342,
-0.02415504865348339,
-0.0007329328800551593,
-0.04202349856495857,
0.014459178782999516,
0.0400649830698967,
-0.027395065873861313,
-0.020358910784125328,
0.02981298789381981,
0.009000717662274837,
0.0009225886897183955,
-0.014434999786317348,
0.0320858359336853,
0.02988552674651146,
-0.013649174943566322,
0.004983943421393633,
-0.04091125354170799,
0.008831462822854519,
0.0029831123538315296,
0.020044580101966858,
0.011636253446340561,
0.023163700476288795,
-0.01755411922931671,
0.03655899316072464,
0.00205523450858891,
-0.008843553252518177,
0.061802107840776443,
-0.027636857703328133,
-0.007701084483414888,
-0.017034266144037247,
-0.013492009602487087,
-0.017940986901521683,
-0.007441157475113869,
0.026718048378825188,
-0.005334542132914066,
-0.0033185991924256086,
0.01796516589820385,
0.026645509526133537,
-0.006328912917524576,
-0.003932146821171045,
0.026427896693348885,
0.019137859344482422,
-0.010650950483977795,
0.0020733687561005354,
0.008746836334466934,
-0.03832407668232918,
-0.04799576848745346,
-0.007392799016088247,
0.02654879353940487,
-0.01819486916065216,
-0.025944313034415245,
0.04250708222389221,
0.012428123503923416,
0.024759529158473015,
0.022849371656775475,
-0.0029816010501235723,
-0.020649060606956482,
-0.021253541111946106,
-0.010941101238131523,
-0.017360685393214226,
-0.007592277601361275,
-0.006486078258603811,
-0.009417809545993805,
0.003608749946579337,
-0.005524953827261925,
-0.01553515437990427,
0.01786844991147518,
-0.0018874909728765488,
-0.006739960052073002,
-0.022921908646821976,
0.014253655448555946,
-0.0019343382446095347,
0.015607692301273346,
-0.024300124496221542,
0.01844875141978264,
-0.003442517714574933,
-0.014664702117443085,
-0.03924288973212242,
0.021483244374394417,
0.00019513393635861576,
-0.009605198167264462,
-0.04942234233021736,
0.008607805706560612,
0.03902527317404747,
-0.006425629835575819,
-0.0019509615376591682,
0.0430632047355175,
-0.015559333376586437,
0.006401450838893652,
-0.03912199288606644,
0.003276285482570529,
-0.018170690163969994,
0.032400164753198624,
-0.0028093240689486265,
-0.010076693259179592,
-0.010239902883768082,
-0.02200309745967388,
-0.006053874269127846,
-0.025871774181723595,
-0.012669915333390236,
0.0011296233860775828,
-0.030006421729922295,
0.01771128550171852,
-0.009919528849422932,
-0.020443538203835487,
0.019246665760874748,
0.01732441782951355,
-0.04170916974544525,
0.020129207521677017,
-0.017348596826195717,
0.027201632037758827,
0.028579847887158394,
0.043184101581573486,
-0.03075597807765007,
-0.0060508521273732185,
0.02043144777417183,
0.003632929176092148,
0.0025101061910390854,
0.007459292188286781,
0.031046129763126373,
-0.013008425012230873,
-0.004071177449077368,
0.01850919984281063,
0.005068570841103792,
-0.03409271314740181,
0.013600816018879414,
-0.03281121328473091,
-0.00651630200445652,
-0.0022501794155687094,
-0.01882352866232395,
0.02599267102777958,
-0.0060508521273732185,
0.02853148989379406,
0.025098038837313652,
0.017542030662298203,
-0.04695606231689453,
0.01355245802551508,
0.010596547275781631,
-0.009514526464045048,
0.026766406372189522,
-0.012694095261394978,
-0.010306396521627903,
0.012065434828400612,
0.008795194327831268,
-0.01786844991147518,
-0.0011054441565647721,
0.017022177577018738,
-0.005240847822278738,
0.017300238832831383,
-0.0013600816018879414,
-0.0062019722536206245,
0.012391855008900166,
-0.013455741107463837,
0.005827194079756737,
0.02231742814183235,
0.019186217337846756,
-0.023949526250362396,
0.03387510031461716,
0.026041029021143913,
-0.005138086155056953,
-0.010808114893734455,
-0.04432052746415138,
0.0036631531547755003,
0.004458045121282339,
0.004624277353286743,
0.1263122856616974,
-0.02981298789381981,
-0.010735577903687954,
0.00005317541217664257,
-0.02599267102777958,
-0.015341720543801785,
0.02041935920715332,
0.006528391502797604,
0.018859798088669777,
-0.022607577964663506,
0.03711511567234993,
-0.005512864328920841,
0.024904605001211166,
-0.005107861943542957,
0.03740526735782623,
-0.016973817721009254,
0.0029936907812952995,
0.018787261098623276,
0.0019116702023893595,
-0.0011198004940524697,
-0.0019116702023893595,
0.019137859344482422,
-0.021483244374394417,
0.018146511167287827,
-0.041298121213912964,
-0.009109524078667164,
0.009049076586961746,
-0.01553515437990427,
0.010880652815103531,
-0.01882352866232395,
0.028265519067645073,
-0.00592391099780798,
0.02073368802666664,
-0.019609354436397552,
-0.011110355146229267,
-0.026282820850610733,
-0.0034848314244300127,
-0.03218255192041397,
0.009188107214868069,
0.012216554954648018,
-0.005824171472340822,
0.01152140274643898,
0.021676678210496902,
0.030248215422034264,
0.03148135542869568,
0.037792135030031204,
-0.023030715063214302,
0.0019010918913409114,
0.0047330837696790695,
-0.017034266144037247,
-0.0034364729654043913,
-0.0008674298296682537,
0.01652650348842144,
-0.017783822491765022,
-0.01813442073762417,
0.0016124523244798183,
0.02812044322490692,
-0.013407382182776928,
-0.030538365244865417,
-0.03880766034126282,
-0.017977256327867508,
0.014253655448555946,
0.025412369519472122,
0.0032702407333999872,
0.018327854573726654
] | 2025-01-15 | 59 | 39809749 | [
"equipped T cells",
"engineered T cells",
"CAR expression",
"cell therapy",
"CAR",
"CARs",
"CAR design",
"Conventional CARs",
"different CD3 subunits",
"CAR-T cells",
"alternative CD3 chains",
"CAR reconstitution",
"diverse tumor antigens",
"signaling modules",
"CD3",
"limited persistence",
"chimeric antigen receptor",
"endoplasmic reticulum retention",
"cytokine release",
"low tonic signal",
"diverse tumors",
"CD3ε-based CARs",
"ICD",
"persistence",
"major challenges",
"minimized cytokines",
"improved safety",
"memory differentiation",
"T",
"these reconstituted CARs"
] | [] | 0 | 10.1038/s41392-024-02096-5 | [
"Wang",
"Wang",
"Zhao",
"Zheng",
"Zhang",
"Meng",
"Dong",
"Liang",
"He",
"Song",
"Su",
"Yan",
"Yang",
"Jia"
] | [
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.\nHenan Key Laboratory of Immunology and Targeted Therapy, School of Medical Technology, Xinxiang Medical University, Xinxiang, Henan, China.\nDepartment of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.\nHenan Key Laboratory of Immunology and Targeted Therapy, School of Medical Technology, Xinxiang Medical University, Xinxiang, Henan, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.\nDepartment of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.\nHenan Key Laboratory of Immunology and Targeted Therapy, School of Medical Technology, Xinxiang Medical University, Xinxiang, Henan, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.\nHenan Key Laboratory of Immunology and Targeted Therapy, School of Medical Technology, Xinxiang Medical University, Xinxiang, Henan, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China.",
"Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.",
"Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China. [email protected].",
"Henan Key Laboratory of Immunology and Targeted Therapy, School of Medical Technology, Xinxiang Medical University, Xinxiang, Henan, China. [email protected].\nDepartment of Immunology, Fourth Military Medical University, Xi'an, Shaanxi, China. [email protected].\nDepartment of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. [email protected].",
"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China. [email protected]."
] | [
"39809749",
"35318469",
"32735779",
"35936003",
"32015021",
"38769449",
"34002066",
"36942414",
"36882513",
"29907163",
"26461090",
"20439624",
"26169254",
"34897277",
"16473826",
"24877875",
"35710755",
"29400710",
"32758419",
"37932456",
"36763234",
"35731927",
"29789755",
"30181329",
"32083149",
"36825901",
"35570136",
"35624210",
"15767451",
"33675691",
"30559421",
"36914891",
"19302050",
"31848223",
"29261409",
"26507128",
"24470497",
"19013279",
"29808005",
"39284972",
"34971569",
"14552840",
"34810156",
"34794490",
"32730808",
"21395513",
"32690949",
"25520398",
"34230645",
"35078657",
"28659468",
"18187657",
"23046126",
"37976958",
"38367240",
"29935385",
"31959992",
"9435250",
"38177245"
] | [] | 8.516855 | 4.963788 |
39809514 | 32 | Weal and woe of interleukin-18 in the T cell therapy of cancer. | Chimeric antigen receptor (CAR) T cell therapy of solid cancer remains below expectations; adding cytokine help through IL-18 has shown remarkable efficacy in first clinical trials. As IL-18 is also a powerful driver of hyperinflammatory conditions, we discuss to what extent unleashing IL-18 is a double-edged sword in CAR T cell therapies. | [
-0.014227522537112236,
0.0036556830164045095,
0.032509125769138336,
0.05168313533067703,
-0.031361743807792664,
-0.02498740516602993,
-0.03273859992623329,
0.001668483018875122,
0.019811443984508514,
0.002033413853496313,
0.019352490082383156,
-0.030469335615634918,
-0.02558659389615059,
0.009268287569284439,
0.0351608507335186,
-0.06782295554876328,
0.028506040573120117,
-0.011295326985418797,
0.027843108400702477,
0.06226453557610512,
-0.01867680996656418,
0.014762966893613338,
-0.04296303912997246,
0.02362329699099064,
-0.021494267508387566,
-0.03898545354604721,
0.005545674357563257,
0.013755821622908115,
0.000180573042598553,
-0.027562638744711876,
0.04456937313079834,
-0.03266210854053497,
-0.011588546447455883,
-0.06088767945766449,
-0.027435151860117912,
0.02186398021876812,
0.0430140346288681,
0.014291265979409218,
-0.024821672588586807,
-0.016790006309747696,
0.016891995444893837,
-0.0030517145060002804,
0.010294556617736816,
0.08679299056529999,
-0.0368436761200428,
0.007706575095653534,
0.01556613389402628,
-0.02684871293604374,
0.021800236776471138,
-0.0040795765817165375,
-0.004101886413991451,
0.004133758135139942,
-0.01482671033591032,
0.036333728581666946,
-0.03722613677382469,
0.04393193870782852,
0.011677787639200687,
0.04084675759077072,
-0.004197501577436924,
-0.009931218810379505,
0.015464144758880138,
-0.028480542823672295,
0.02488541603088379,
-0.04018382728099823,
-0.050969209522008896,
-0.0014589267084375024,
-0.04617570713162422,
-0.003980773966759443,
0.017746157944202423,
0.027358658611774445,
0.015515139326453209,
-0.025255128741264343,
0.0005756824393756688,
0.012455456890165806,
0.03327404707670212,
-0.002006322843953967,
-0.02825106680393219,
-0.0014262581244111061,
0.02470693551003933,
-0.009389400482177734,
0.011199711821973324,
0.015438647009432316,
0.0016119107604026794,
-0.03778707608580589,
0.024439211934804916,
-0.011728782206773758,
0.01740194298326969,
-0.03233064338564873,
-0.04296303912997246,
0.006364776752889156,
0.005940883420407772,
0.009695368818938732,
-0.04018382728099823,
0.01463548094034195,
0.023432066664099693,
0.027460649609565735,
0.003936153836548328,
-0.023916516453027725,
0.0040253945626318455,
0.03521184250712395,
0.05084172263741493,
-0.011512055061757565,
-0.03276409953832626,
0.02196596935391426,
0.011620418168604374,
-0.0010844343341886997,
-0.0821014791727066,
-0.039214927703142166,
0.0175804253667593,
-0.024859918281435966,
0.10545705258846283,
0.0021943659521639347,
-0.048623450100421906,
0.03755760192871094,
-0.024235233664512634,
-0.053952399641275406,
-0.03095378540456295,
0.006192669738084078,
-0.008598982356488705,
-0.0013569372240453959,
-0.011365445330739021,
0.04915889725089073,
0.03401346877217293,
-0.002278825966641307,
-0.008547987788915634,
-0.0424530915915966,
0.0777159333229065,
-0.011046728119254112,
-0.0368436761200428,
-0.05640014261007309,
0.02420973591506481,
0.04867444559931755,
-0.002156119793653488,
0.019594715908169746,
-0.03873047977685928,
0.0036588702350854874,
-0.011174215003848076,
0.019288746640086174,
-0.050306275486946106,
-0.028735516592860222,
0.017210712656378746,
-0.02194047160446644,
-0.020614609122276306,
-0.03161671757698059,
-0.025535598397254944,
-0.053187478333711624,
-0.012123990803956985,
0.009657122194766998,
0.016267310827970505,
0.03885796666145325,
-0.0008597388514317572,
0.0424530915915966,
0.03085179626941681,
0.0028413613326847553,
0.007069141138345003,
-0.02993389219045639,
-0.007030894979834557,
0.020971572026610374,
-0.01807762309908867,
-0.02536986581981182,
-0.014431501738727093,
0.007324114441871643,
-0.027001695707440376,
-0.039214927703142166,
0.037073150277137756,
-0.010587776079773903,
0.005013416986912489,
0.03541582450270653,
-0.02891399711370468,
-0.037073150277137756,
-0.05379941314458847,
-0.036792680621147156,
-0.09775684773921967,
-0.03946990147233009,
-0.054309360682964325,
0.007489847484976053,
0.021150054410099983,
0.02474518120288849,
-0.03125975281000137,
0.005873952526599169,
0.03702215477824211,
0.03289158642292023,
-0.002124248305335641,
-0.025382613763213158,
-0.022067958489060402,
0.008579859510064125,
-0.009561507031321526,
0.010657893493771553,
-0.03579828143119812,
0.03997984901070595,
0.004592710640281439,
0.018715057522058487,
0.06058171018958092,
0.022832879796624184,
0.017248958349227905,
-0.02278188429772854,
0.041535187512636185,
0.04607371613383293,
-0.037608593702316284,
-0.02092057839035988,
0.011027605272829533,
-0.010288181714713573,
-0.0261857807636261,
-0.011626793071627617,
-0.0022597028873860836,
-0.005889888387173414,
-0.026440754532814026,
0.049184393137693405,
-0.028557034209370613,
0.012844291515648365,
0.032483626157045364,
-0.0022055211011320353,
-0.0038755976129323244,
-0.0024732432793825865,
-0.01379406824707985,
-0.001088418299332261,
0.012914408929646015,
0.06542620807886124,
0.036792680621147156,
0.010084203444421291,
-0.012047499418258667,
-0.01426576916128397,
-0.03215216100215912,
-0.0023951574694365263,
-0.021315786987543106,
0.005160026717931032,
0.004659641068428755,
-0.02150701731443405,
0.014864956960082054,
0.005784711800515652,
0.005615791771560907,
0.0005868375301361084,
0.013118388131260872,
-0.04428890347480774,
-0.020958824083209038,
-0.042198117822408676,
0.015502390451729298,
0.025918059051036835,
0.059255849570035934,
-0.01761867105960846,
0.008771088905632496,
0.040132831782102585,
0.03794006258249283,
-0.004956047981977463,
-0.0360022634267807,
-0.013233126141130924,
0.009861101396381855,
-0.07470723986625671,
-0.029806405305862427,
-0.012933531776070595,
0.019734950736165047,
0.02789410389959812,
-0.02526787668466568,
0.00003981471309089102,
0.006928905379027128,
0.002006322843953967,
0.04232560470700264,
-0.0317951999604702,
-0.035568807274103165,
-0.021417776122689247,
0.032407134771347046,
0.003125019371509552,
-0.021812984719872475,
-0.05808296799659729,
-0.031744204461574554,
-0.0036875547375530005,
-0.031208759173750877,
0.017452938482165337,
-0.014036293141543865,
-0.025076646357774734,
0.05257553979754448,
0.030418341979384422,
0.052167583256959915,
-0.010116075165569782,
-0.06109165772795677,
-0.009204544126987457,
-0.0143550094217062,
0.03903644531965256,
0.0194034855812788,
-0.0005414203624241054,
-0.0287100188434124,
-0.005268390290439129,
-0.0287100188434124,
-0.03819503262639046,
-0.016445793211460114,
-0.0410507395863533,
0.044161416590213776,
-0.035925768315792084,
0.046022720634937286,
-0.05578820779919624,
0.013590089045464993,
-0.0013011618284508586,
0.012028376571834087,
0.0396483838558197,
-0.006285097450017929,
0.02769012562930584,
0.003493137424811721,
0.002546548144891858,
-0.010536780580878258,
0.0004948080168105662,
0.0021736493799835443,
0.030826300382614136,
-0.010402919724583626,
0.002331414259970188,
-0.014673726633191109,
-0.008573484607040882,
-0.029627924785017967,
-0.009287410415709019,
0.032509125769138336,
0.04288654774427414,
0.04548727720975876,
0.023814527317881584,
-0.0008764715166762471,
0.04270806536078453,
-0.017809901386499405,
0.041356705129146576,
0.02498740516602993,
-0.04382994771003723,
0.04663465917110443,
-0.011869017966091633,
-0.018434586003422737,
-0.006272348575294018,
-0.01571911759674549,
0.01482671033591032,
0.02070385031402111,
-0.025752326473593712,
0.025178635492920876,
-0.024719683453440666,
-0.027766617015004158,
-0.022055210545659065,
-0.022310184314846992,
-0.02088233269751072,
0.04892941936850548,
0.013169382698833942,
0.02449020743370056,
-0.04347298666834831,
-0.04645617678761482,
-0.05436035618185997,
0.07195352762937546,
-0.016343802213668823,
-0.014304014854133129,
0.03419195115566254,
-0.055635225027799606,
0.06410034745931625,
-0.011849895119667053,
0.0052747647278010845,
-0.02134128473699093,
0.032585617154836655,
0.010307304561138153,
0.009561507031321526,
0.008592607453465462,
0.04533429443836212,
-0.002613478573039174,
0.010377422906458378,
-0.0010095358593389392,
0.03839901462197304,
-0.04038780555129051,
-0.014890453778207302,
0.0085097411647439,
0.00029202437144704163,
0.009873850271105766,
0.006508199498057365,
-0.06017375364899635,
0.05900087580084801,
0.024375468492507935,
0.030698813498020172,
-0.028557034209370613,
0.04128021374344826,
-0.02526787668466568,
-0.02056361548602581,
-0.008605356328189373,
-0.016369299963116646,
0.04150969162583351,
-0.020627358928322792,
0.008713720366358757,
0.06659908592700958,
0.02947494015097618,
0.002270858036354184,
0.047042615711688995,
-0.00460545951500535,
0.021430524066090584,
0.0035409447737038136,
0.003429393982514739,
-0.03776158019900322,
-0.0029576928354799747,
0.02498740516602993,
0.01698123663663864,
-0.008101783692836761,
-0.03666519373655319,
0.07608409970998764,
0.02414599247276783,
-0.039571892470121384,
-0.00008734835137147456,
0.01440600398927927,
-0.012901660054922104,
0.06593615561723709,
-0.012251477688550949,
0.08653801679611206,
0.033758495002985,
0.015285663306713104,
-0.013258623890578747,
-0.032687604427337646,
-0.026823215186595917,
-0.03143823519349098,
0.012385339476168156,
0.004818999674171209,
0.03284059092402458,
0.0030915539246052504,
0.010874620638787746,
-0.02916897088289261,
-0.00425487058237195,
-0.010900118388235569,
0.047960519790649414,
0.017962884157896042,
-0.02516588754951954,
-0.0017370071727782488,
-0.020168406888842583,
0.005851642228662968,
-0.011237958446145058,
0.02891399711370468,
0.03694566339254379,
-0.017465686425566673,
0.028378553688526154,
-0.004927363246679306,
0.016751760616898537,
0.003094741143286228,
0.042759060859680176,
0.004216624889522791,
0.015464144758880138,
-0.0185620728880167,
-0.022922120988368988,
0.022373927757143974,
0.0025991364382207394,
-0.02530612237751484,
-0.012296098284423351,
0.016573280096054077,
-0.03786356747150421,
0.0024079063441604376,
-0.02018115483224392,
0.022220943123102188,
0.008152778260409832,
0.016586028039455414,
0.007732072379440069,
-0.033885981887578964,
-0.0008828458376228809,
0.01649678684771061,
0.029525933787226677,
0.02466868795454502,
-0.034650903195142746,
-0.004994294140487909,
-0.0427335649728775,
-0.03493137285113335,
-0.002031820360571146,
0.0396483838558197,
-0.009191795252263546,
0.013743072748184204,
0.03646121546626091,
-0.04729758948087692,
0.01947997696697712,
0.03477839007973671,
-0.0002272849960718304,
-0.053646430373191833,
0.0033305916003882885,
0.0035760037135332823,
-0.05033177509903908,
0.048827432096004486,
0.01445699855685234,
-0.014546239748597145,
0.025918059051036835,
-0.013335115276277065,
-0.016904745250940323,
-0.019734950736165047,
-0.028863003477454185,
0.02126479148864746,
0.014431501738727093,
-0.0003402302972972393,
0.03755760192871094,
0.009134426712989807,
0.01058140117675066,
-0.0026278209406882524,
-0.03804204985499382,
-0.006744049955159426,
-0.017172466963529587,
-0.029576929286122322,
0.04982182756066322,
-0.005657224915921688,
-0.023253586143255234,
-0.03227964788675308,
-0.016025086864829063,
-0.014278517104685307,
0.002524237846955657,
-0.020028170198202133,
0.03243263438344002,
-0.013602837920188904,
0.0038341644685715437,
-0.006559194065630436,
0.012551072053611279,
0.0033656505402177572,
-0.0002991954970639199,
0.008822084404528141,
0.006046059541404247,
0.047221098095178604,
0.0135135967284441,
-0.009637999348342419,
0.035925768315792084,
0.04954135790467262,
0.02965342067182064,
0.03284059092402458,
-0.009363902732729912,
0.01597409136593342,
-0.016904745250940323,
-0.003161671804264188,
0.060275740921497345,
-0.03980136662721634,
-0.044161416590213776,
-0.022654397413134575,
-0.049286384135484695,
-0.01628006063401699,
-0.005147278308868408,
-0.008720094338059425,
-0.013437105342745781,
-0.0006139284232631326,
-0.03735361993312836,
0.0005270781111903489,
0.05028077960014343,
-0.02730766497552395,
0.005708219949156046,
0.039214927703142166,
-0.003435768187046051,
-0.0345999076962471,
0.047323085367679596,
-0.020448876544833183,
0.016305556520819664,
0.01986243762075901,
-0.006846039090305567,
-0.022641649469733238,
-0.024859918281435966,
0.03646121546626091,
-0.009051560424268246,
-0.04625219851732254,
0.037710584700107574,
0.011543926782906055,
0.03309556469321251,
-0.0031664525158703327,
-0.008337634615600109,
0.03906194493174553,
-0.008324885740876198,
-0.02049987204372883,
0.024974657222628593,
-0.016726262867450714,
0.03245813027024269,
-0.01524741668254137,
0.041152726858854294,
-0.005810209084302187,
0.01691749319434166,
-0.007936051115393639,
0.00273777823895216,
-0.05731805041432381,
-0.008822084404528141,
-0.03457441180944443,
-0.026160283014178276,
-0.02336832322180271,
-0.011486557312309742,
-0.014163779094815254,
-0.024553950875997543,
-0.012901660054922104,
-0.0041815657168626785,
-0.01691749319434166,
-0.0212265457957983,
0.05099470540881157,
0.009982213377952576,
0.04548727720975876,
0.001591194188222289,
-0.04314152151346207,
0.05772600695490837,
-0.0035728164948523045,
-0.006030124146491289,
0.008904950693249702,
-0.005979129113256931,
0.030443839728832245,
-0.01144193671643734,
-0.0077575696632266045,
-0.03653770685195923,
0.025344368070364,
-0.005303449463099241,
0.027103686705231667,
-0.0023266335483640432,
-0.027996093034744263,
-0.028557034209370613,
-0.011531177908182144,
0.04298853501677513,
0.020907828584313393,
0.025522850453853607,
0.013590089045464993,
-0.028608029708266258,
0.043396495282649994,
0.006629311945289373,
-0.02740965411067009,
0.002587981289252639,
0.028378553688526154,
0.0036015009973198175,
-0.025675835087895393,
-0.042019639164209366,
-0.03171870857477188,
-0.023852773010730743,
0.03278959542512894,
-0.0026294144336134195,
0.002914666198194027,
-0.0025385802146047354,
0.0016493600560352206,
0.05951081961393356,
0.007406981196254492,
-0.04607371613383293,
0.008203772827982903,
-0.009389400482177734,
0.0045449030585587025,
-0.0014525522710755467,
0.0100523317232728,
0.0041847531683743,
-0.002817457541823387,
0.002638976089656353,
-0.01656053029000759,
-0.014010795392096043,
0.0038341644685715437,
-0.00046931064571253955,
-0.02972991392016411,
0.010721636936068535,
-0.012646687217056751,
0.023049606010317802,
0.011065850965678692,
-0.006163985002785921,
-0.02232293225824833,
-0.015260165557265282,
0.03653770685195923,
0.0016182850813493133,
-0.06991374492645264,
0.024936411529779434,
0.00840775202959776,
-0.000820696062874049,
0.0001406338415108621,
0.007081889547407627,
0.018511077389121056,
-0.0005724952206946909,
-0.012072996236383915,
0.035186346620321274,
0.008299387991428375,
-0.019416233524680138,
0.015094432979822159,
0.022718140855431557,
0.005252454895526171,
0.00891132466495037,
-0.01653503254055977,
-0.01937798783183098,
-0.006622937507927418,
0.006399835459887981,
-0.0170194823294878,
0.02494915947318077,
-0.030341850593686104,
0.05578820779919624,
0.040617283433675766,
-0.003064463147893548,
0.0006107412627898157,
-0.03001038357615471,
0.0003201112849637866,
-0.007241248153150082,
0.031030278652906418,
-0.012710430659353733,
0.0014238677686080337,
0.034548912197351456,
-0.00011673006520140916,
0.08954670280218124,
0.028863003477454185,
-0.020589113235473633,
-0.016573280096054077,
-0.019530972465872765,
0.007693826220929623,
-0.012901660054922104,
-0.017962884157896042,
-0.013539094477891922,
0.008656350895762444,
-0.011569423601031303,
0.01729995384812355,
-0.0020302266348153353,
-0.0765940472483635,
-0.007642831653356552,
-0.0050644115544855595,
0.008598982356488705,
-0.0066866809502244,
0.01849832944571972,
-0.037812575697898865,
-0.01342435646802187,
-0.0063010333105921745,
-0.020512619987130165,
-0.015438647009432316,
0.013347864151000977,
0.015170925296843052,
-0.02428622916340828,
-0.0023377884645015,
-0.015132678672671318,
0.05594119057059288,
0.04375345632433891,
0.00016364121984224766,
0.013959800824522972,
-0.04474785551428795,
0.008050789125263691,
-0.03480388596653938,
0.0037640465889126062,
-0.01179252564907074,
0.006871536374092102,
0.04831748455762863,
0.0030501207802444696,
0.008445997722446918,
-0.02519138529896736,
-0.006135300733149052,
0.006877910811454058,
-0.018715057522058487,
0.005306636448949575,
0.01398529764264822,
0.003961651120334864,
0.00882845837622881,
0.002678815508261323,
0.008745592087507248,
-0.0030246234964579344,
-0.015272914431989193,
0.05680810287594795,
-0.002183210803195834,
-0.07807289063930511,
0.03199917823076248,
0.006795044522732496,
0.005268390290439129,
0.004251683596521616,
-0.04263157397508621,
-0.01684100180864334,
0.004573587793856859,
-0.01556613389402628,
0.023776281625032425,
-0.021188300102949142,
-0.006189482286572456,
-0.010779005475342274,
-0.029296457767486572,
0.02270539291203022,
-0.02712918259203434,
-0.009102554991841316,
0.02080583944916725,
0.012429959140717983,
0.02052536979317665,
0.005389502737671137,
0.02944944240152836,
-0.008866704069077969,
-0.0295514315366745,
-0.002729810308665037,
0.010014085099101067,
0.0029640672728419304,
0.014762966893613338,
-0.001125070732086897,
-0.04959234967827797,
0.0023282270412892103,
0.00394890271127224,
0.00849061831831932,
-0.024362720549106598,
-0.012735927477478981,
0.0054628076031804085,
0.01607608050107956,
0.0368436761200428,
-0.021430524066090584,
0.03857749328017235,
-0.0010214876383543015,
0.01695573888719082,
-0.025841567665338516,
-0.017032232135534286,
-0.03722613677382469,
-0.032407134771347046,
0.0031744204461574554,
-0.01645854115486145,
-0.008656350895762444,
0.025892561301589012,
0.004098699428141117,
-0.0108937444165349,
-0.018791548907756805,
0.006654809229075909,
0.022131701931357384,
-0.014342260546982288,
-0.0019027399830520153,
0.016203567385673523,
-0.033325038850307465,
-0.013704827055335045,
0.01100210752338171,
-0.004602272063493729,
-0.02807258628308773,
-0.01638204976916313,
-0.014049041084945202,
0.004704261664301157,
-0.021048065274953842,
0.006288284435868263,
-0.02901598811149597,
0.03393697738647461,
0.04087225720286369,
-0.07633907347917557,
-0.015081684105098248,
-0.005864391103386879,
0.017554927617311478,
-0.03648671135306358,
-0.012665810063481331,
-0.02136678248643875,
-0.008050789125263691,
-0.010575027205049992,
0.0015919909346848726,
-0.0009943967452272773,
-0.011658664792776108,
0.014240271411836147,
-0.023993009701371193,
-0.025777824223041534,
0.012461830861866474,
-0.004034955985844135,
-0.019556470215320587,
-0.02196596935391426,
0.04446738213300705,
0.009816480800509453,
-0.0100523317232728,
-0.012716804631054401,
0.04818999767303467,
-0.002007916569709778,
0.012410836294293404,
-0.0033242173958569765,
0.008191024884581566,
-0.049286384135484695,
-0.02814907766878605,
0.0015091245295479894,
0.012168611399829388,
-0.005564797203987837,
0.015833856537938118,
0.01705772988498211,
-0.018128618597984314,
0.021774739027023315,
0.0015872102230787277,
-0.026096541434526443,
-0.006348840892314911,
0.02474518120288849,
0.008031666278839111,
0.023699790239334106,
0.0025688582099974155,
-0.013781319372355938,
-0.028964992612600327,
-0.030545828863978386,
0.020397882908582687,
0.0027505268808454275,
-0.028608029708266258,
0.012321596033871174,
0.010332802310585976,
-0.039291419088840485,
0.0006207011756487191,
-0.002427029190585017,
0.002274045255035162,
-0.009924844838678837,
0.02042337879538536,
0.0323561392724514,
0.04008184000849724,
-0.036588702350854874,
0.04102523997426033,
0.029806405305862427,
-0.026020048186182976,
0.02182573452591896,
0.000059161826357012615,
-0.04232560470700264,
0.008452372625470161,
-0.02695070207118988,
-0.005921760108321905,
0.0062468512915074825,
0.008771088905632496,
-0.024260731413960457,
0.05359543487429619,
-0.00004026290844194591,
-0.0013537501217797399,
-0.03031635284423828,
-0.017325451597571373,
-0.009006939828395844,
0.025140389800071716,
-0.008669099770486355,
-0.036129750311374664,
0.014202025718986988,
0.023521307855844498,
-0.02536986581981182,
0.02474518120288849,
-0.03839901462197304,
0.024439211934804916,
0.017006734386086464,
0.004493908490985632,
0.013041895814239979,
-0.0003964041534345597,
0.02494915947318077,
-0.014329512603580952,
0.011320824734866619,
-0.0002788772981148213,
-0.03926592320203781,
0.024681437760591507,
0.01761867105960846,
-0.013615586794912815,
0.055329255759716034,
-0.033350538462400436,
-0.00849061831831932,
-0.0260455459356308,
-0.031004780903458595,
0.018829794600605965,
0.034829385578632355,
0.012200483120977879,
0.003187169088050723,
0.0032015114556998014,
0.02769012562930584,
-0.01877880096435547,
-0.0010836374713107944,
0.011671413667500019,
0.0018613067222759128,
0.0048221866600215435,
0.03077530488371849,
0.012793296948075294,
0.014010795392096043,
0.0160378348082304,
0.04663465917110443,
-0.004847684409469366,
-0.005131342448294163,
-0.016522284597158432,
-0.001074872794561088,
0.022552408277988434,
0.009147175587713718,
-0.01046028919517994,
0.03350352123379707,
0.006839664652943611,
0.0032031049486249685,
0.015056186355650425,
0.022577906027436256,
0.006208605598658323,
0.014801213517785072,
0.03794006258249283,
0.02628776989877224,
-0.008095409721136093,
0.004758443683385849,
0.03289158642292023,
0.021239295601844788,
0.004187940154224634,
0.006199043709784746,
-0.02204246073961258,
0.017006734386086464,
-0.0203851331025362,
-0.03513535112142563,
0.026364263147115707,
0.002709093736484647,
0.019237753003835678,
-0.04923538863658905,
0.013245875015854836,
0.015336657874286175,
0.04660915955901146,
-0.008414126001298428,
0.0184218380600214,
0.041458696126937866,
-0.015400401316583157,
0.0031999177299439907,
0.004057266283780336,
-0.043039530515670776,
0.02677221968770027,
-0.009548758156597614,
-0.0388069711625576,
-0.008592607453465462,
0.007164756301790476,
-0.0184218380600214,
0.003429393982514739,
0.03778707608580589,
-0.0021114994306117296,
0.03233064338564873,
-0.03722613677382469,
0.03467639908194542,
-0.02565033733844757,
-0.032126665115356445,
-0.012296098284423351,
0.0010015679290518165,
0.026134787127375603,
0.024158742278814316,
0.03317205607891083,
-0.06537520885467529,
0.02362329699099064,
0.012225980870425701,
0.006524135358631611,
0.02449020743370056,
-0.0064221457578241825,
0.014558988623321056,
-0.016088830307126045,
0.01733819954097271,
-0.007368735037744045,
0.004143320024013519,
-0.02228468656539917,
-0.01394705194979906,
0.023954762145876884,
0.005233331583440304,
0.004669202491641045,
-0.047221098095178604,
-0.00884120725095272,
-0.04224911332130432,
-0.015081684105098248,
-0.028964992612600327,
0.028786512091755867,
0.03001038357615471,
-0.024235233664512634,
-0.014367758296430111,
0.032203156501054764,
-0.0365632027387619,
-0.033707499504089355,
0.00887945294380188,
0.040234822779893875,
0.0002004928537644446,
0.005937695968896151,
-0.0534934476017952,
0.020627358928322792,
0.019428983330726624,
-0.002670847810804844,
-0.027486145496368408,
0.0069416542537510395,
-0.023712538182735443,
-0.018791548907756805,
-0.023699790239334106,
-0.04625219851732254,
0.01919950731098652,
0.0028302061837166548,
-0.018931783735752106,
-0.01514542754739523,
0.022297434508800507,
0.04699162021279335,
0.0034548912663012743,
0.013309618458151817,
-0.009867475368082523,
0.03564529865980148,
0.008598982356488705,
0.0178608950227499,
-0.003458078484982252,
0.008713720366358757,
0.010007711127400398,
-0.02372528612613678,
0.01228334940969944,
-0.013041895814239979,
0.05492129921913147,
0.057777002453804016,
0.02449020743370056,
-0.035492315888404846,
-0.013590089045464993,
-0.0151964221149683,
0.0624685138463974,
-0.026899706572294235,
-0.01473747007548809,
0.000508751894813031,
-0.048164498060941696,
0.03653770685195923,
0.04071927070617676,
0.060377731919288635,
0.04166267439723015,
-0.0017417878843843937,
0.011926386505365372,
-0.0026055106427520514,
0.018817046657204628,
-0.005070785991847515,
0.020538117736577988,
0.013048270717263222,
0.005858016666024923,
-0.0019617024809122086,
-0.008127281442284584,
-0.001791189075447619,
-0.01482671033591032,
0.0029608800541609526,
0.0058484552428126335,
0.021392278373241425,
0.00882845837622881,
0.004681951366364956,
0.03138723969459534,
-0.0030262169893831015,
-0.0029353827703744173,
0.0008971880888566375,
-0.0016174883348867297,
-0.0045449030585587025,
-0.007572713773697615,
-0.0007987842545844615,
-0.015744615346193314,
-0.00571140693500638,
-0.0365632027387619,
0.02825106680393219,
-0.0006685086991637945,
0.04288654774427414,
0.02088233269751072,
-0.01831984706223011,
-0.03467639908194542,
0.004783940967172384,
0.0014995631063356996,
0.0023855960462242365,
-0.01877880096435547,
-0.014278517104685307,
0.0006888268981128931,
-0.02194047160446644,
0.0000645899708615616,
-0.006635685916990042,
0.012780548073351383,
-0.015298411250114441,
0.027537140995264053,
0.029500437900424004,
-0.030188865959644318,
-0.004187940154224634,
0.005389502737671137,
0.005934508983045816,
-0.04235110431909561,
-0.033707499504089355,
0.045283298939466476,
-0.024655940011143684,
-0.05369742587208748,
0.040795765817165375,
0.01712147146463394,
-0.023636046797037125,
0.040617283433675766,
0.024974657222628593,
-0.0438554473221302,
0.015183673240244389,
-0.005364005453884602,
-0.002635788870975375,
-0.03396247327327728,
0.002070066286250949,
0.04222361743450165,
-0.025000154972076416,
-0.026517247781157494,
-0.009784609079360962,
0.013755821622908115,
-0.0019505474483594298,
-0.012602066621184349,
-0.016012337058782578,
0.01663702353835106,
-0.0023218526039272547,
0.013832313939929008,
-0.028608029708266258,
-0.002615072298794985,
0.0287100188434124,
0.00023186655016615987,
0.0175804253667593,
-0.01775890588760376,
0.011097722686827183,
-0.016828252002596855,
0.027384156361222267,
0.01852382719516754,
0.022832879796624184,
0.041152726858854294,
-0.006909782532602549,
-0.012857040390372276,
-0.03225415199995041,
-0.041458696126937866,
-0.015782861039042473,
0.06318244338035583,
-0.017363697290420532,
-0.01144193671643734,
0.03898545354604721,
-0.0017800339264795184,
-0.0009688994032330811,
0.014023544266819954,
-0.0035058860667049885,
0.012697681784629822,
0.007846809923648834,
-0.024337222799658775,
0.018256105482578278,
0.0194034855812788,
-0.005443684756755829,
-0.017669664695858955,
0.017924638465046883,
-0.0024987405631691217,
-0.0009338405216112733,
-0.005603043362498283,
-0.02554834820330143,
0.0004362437757663429,
0.023100601509213448,
-0.040795765817165375,
0.003932966850697994,
0.015846604481339455,
0.010345551185309887,
0.0402093268930912,
0.023878270760178566,
0.00021852027566637844,
0.03895995393395424,
0.011104097589850426,
-0.019110266119241714,
-0.023712538182735443,
0.021519765257835388,
-0.0009920063894242048,
-0.02769012562930584,
-0.023240836337208748,
-0.02322808839380741,
-0.007712949067354202,
0.030545828863978386,
0.0028684521093964577,
-0.03615524619817734,
-0.003929779399186373,
0.0022055211011320353,
-0.025535598397254944,
-0.0292709618806839,
-0.008280265145003796,
-0.0076364572159945965,
0.010364674031734467,
-0.0047425078228116035,
-0.043957434594631195,
-0.04505382105708122,
0.047323085367679596,
-0.004076389130204916,
0.0065783169120550156,
0.01659877598285675,
0.006214979570358992,
0.027282167226076126,
0.0076364572159945965,
-0.0025959492195397615,
-0.028888501226902008,
-0.01147380843758583,
-0.07225950062274933,
0.019658459350466728,
-0.023610549047589302,
0.007132884580641985,
0.018753303214907646,
-0.02260340377688408,
-0.029576929286122322,
-0.0029895645566284657,
0.011186963878571987,
0.0033656505402177572,
-0.020232150331139565,
0.02148151956498623,
-0.016675269231200218,
0.015821106731891632,
0.013959800824522972,
0.026593739166855812,
-0.03161671757698059,
0.0030549014918506145,
0.004697887226939201,
-0.0038246028125286102,
0.011964633129537106,
-0.018664062023162842,
-0.01063239574432373,
-0.0013410013634711504,
-0.024719683453440666,
0.025739578530192375,
-0.017554927617311478,
0.003728987881913781,
-0.005268390290439129,
-0.016241813078522682,
-0.00261029158718884,
-0.02158350870013237,
0.015272914431989193,
-0.005351257044821978,
0.019887935370206833,
0.012028376571834087,
0.011837146244943142,
0.03590027242898941,
0.0185620728880167,
0.023011360317468643,
-0.02730766497552395,
0.004694700241088867,
0.0010334395337849855,
0.001980825560167432,
-0.009555133059620857,
-0.02066560462117195,
-0.009816480800509453,
0.016484038904309273,
-0.02551010064780712,
-0.005880326963961124,
0.014431501738727093,
0.008975068107247353,
0.01677725836634636,
-0.001880429801531136,
-0.00008042622357606888,
-0.017032232135534286,
-0.023610549047589302,
0.012060248292982578,
0.026096541434526443,
0.002481211209669709,
0.010619647800922394,
0.02340656891465187,
0.045257799327373505,
-0.016025086864829063,
0.03125975281000137,
-0.00265013100579381,
0.040591783821582794,
-0.028659025207161903,
-0.02677221968770027,
0.00486999424174428,
-0.002766462741419673,
-0.005749653093516827,
0.007292242720723152,
0.04411042109131813,
0.026096541434526443,
-0.02432447485625744,
0.04390644282102585,
0.007502595894038677,
0.0008780650678090751,
0.002074846997857094,
-0.003582378150895238,
0.00522058317437768,
-0.0063329050317406654,
0.0035313833504915237,
-0.010798129253089428,
0.000776872446294874,
0.014890453778207302,
-0.008567110635340214,
0.009134426712989807,
-0.0018947720527648926,
-0.005402251612395048,
-0.0021417776588350534,
-0.007502595894038677,
0.013972549699246883,
-0.02032138966023922,
-0.052269574254751205,
0.0019266437739133835,
-0.008624479174613953,
-0.0071838791482150555,
0.004191127140074968,
-0.015272914431989193,
0.02200421504676342,
0.03842451050877571,
0.006288284435868263,
0.003859661752358079,
0.012474579736590385,
-0.02294761687517166,
0.01824335567653179,
-0.0014963758876547217,
0.007559964898973703,
0.019658459350466728,
-0.029423944652080536,
-0.023036858066916466,
-0.019314244389533997,
-0.013169382698833942,
0.0292709618806839,
-0.006559194065630436,
0.006916156969964504,
0.03276409953832626,
-0.014431501738727093,
-0.008968694135546684,
0.0142147745937109,
-0.03411545976996422,
0.02972991392016411,
-0.01310563925653696,
-0.010957486927509308,
-0.0038469131104648113,
-0.0058484552428126335,
-0.024337222799658775,
0.0026262274477630854,
-0.007113761268556118,
-0.0315147265791893,
0.0007804580382071435,
0.03419195115566254,
0.009695368818938732,
-0.0022963553201407194,
0.005392690189182758,
-0.009504138492047787,
0.045844241976737976,
0.0022549221757799387,
-0.00018794338393490762,
-0.0012987713562324643,
-0.010007711127400398,
-0.0303928442299366,
0.02807258628308773,
0.0010406107176095247,
-0.027078188955783844,
0.003607875434681773,
-0.0025449544191360474,
0.016484038904309273,
0.028608029708266258,
0.005510615184903145,
-0.019072020426392555,
0.01775890588760376,
-0.025981802493333817,
-0.029576929286122322,
-0.03903644531965256,
-0.0357217900454998,
0.029525933787226677,
-0.04252958297729492,
0.002635788870975375,
-0.0004601475375238806,
0.0026341951452195644,
0.015170925296843052,
-0.010288181714713573,
0.009497763589024544,
0.02494915947318077,
-0.006313782185316086,
-0.005972754675894976,
-0.014367758296430111,
-0.004522592760622501,
-0.010645144619047642,
-0.014762966893613338,
-0.027256669476628304,
-0.04586973786354065,
0.02477067895233631,
-0.004984732251614332,
0.016471289098262787,
-0.05130067467689514,
0.013653832487761974,
0.031642213463783264,
-0.0061257388442754745,
-0.019811443984508514,
0.019989924505352974,
-0.01217498630285263,
0.029959389939904213,
-0.032101165503263474,
0.015553385019302368,
-0.004672389943152666,
0.04492633417248726,
-0.0032445380929857492,
-0.0028812007512897253,
-0.015489641577005386,
-0.03187169134616852,
-0.028786512091755867,
0.00697352597489953,
-0.016471289098262787,
0.02078034169971943,
-0.019174009561538696,
0.01902102492749691,
0.0343194380402565,
0.0016891995910555124,
-0.006479514762759209,
0.015833856537938118,
-0.00004372397597762756,
-0.01944173127412796,
0.0019011463737115264,
0.030341850593686104,
0.02901598811149597,
0.051606640219688416,
-0.01642029546201229,
-0.022552408277988434,
0.010549529455602169,
0.025497352704405785,
-0.011716033332049847,
0.0057145943865180016,
0.02832755818963051,
-0.036333728581666946,
-0.029780907556414604,
0.025357117876410484,
0.02280738204717636,
-0.03620624169707298,
-0.02140502817928791,
-0.046685654670000076,
0.017274456098675728,
0.009268287569284439,
-0.04411042109131813,
-0.006986274849623442,
-0.024974657222628593,
0.006119364872574806,
0.01807762309908867,
0.00522058317437768,
-0.03607875481247902,
0.024133244529366493,
-0.00959975365549326,
0.009459517896175385,
0.0002175242843804881,
-0.024974657222628593,
0.022373927757143974,
0.008592607453465462,
0.017210712656378746,
0.022195445373654366,
0.038934458047151566,
0.012678558938205242,
-0.018995527178049088,
0.004560838919132948,
-0.027664627879858017,
-0.0034166453406214714,
0.019875185564160347,
-0.012347092851996422,
-0.005303449463099241,
0.003102709073573351,
0.030622320249676704,
-0.014036293141543865,
0.014699223451316357,
0.016713514924049377,
-0.02252691052854061,
0.01014157198369503,
-0.04686413332819939,
-0.0031441422179341316,
-0.00037648435682058334,
-0.0030724310781806707,
0.07006672769784927,
-0.04148419201374054,
0.01093199010938406,
0.006897034123539925,
-0.037634093314409256,
-0.0005549658089876175,
-0.005695471074432135,
-0.008554361760616302,
0.007464350201189518,
-0.0031234256457537413,
0.00722849927842617,
-0.019530972465872765,
0.03154022619128227,
-0.009841978549957275,
0.005580733064562082,
-0.014151031151413918,
-0.02434997260570526,
0.0574200376868248,
-0.002066879067569971,
0.0023553180508315563,
-0.025102144107222557,
0.0017688788939267397,
-0.06450830399990082,
-0.0029178534168750048,
-0.02712918259203434,
-0.020130159333348274,
-0.005501053761690855,
0.009587004780769348,
-0.016343802213668823,
-0.010402919724583626,
0.009236415848135948,
-0.0007948002894409001,
0.0036333727184683084,
-0.024655940011143684,
-0.005150465294718742,
-0.0035122602712363005,
-0.03003588132560253,
-0.019275998696684837,
0.010549529455602169,
0.01691749319434166,
0.004962422419339418,
0.03495687246322632,
0.012812419794499874,
0.030596822500228882,
0.047221098095178604,
0.016407545655965805,
-0.021073561161756516,
-0.0038054799661040306,
0.02378902956843376,
-0.015094432979822159,
-0.0077703180722892284,
-0.019811443984508514,
0.01510718185454607,
0.008095409721136093,
-0.023279083892703056,
-0.03773608058691025,
0.026925204321742058,
-0.003521821927279234,
-0.00040736005757935345,
-0.017427440732717514,
0.012104867957532406,
0.01715971902012825,
-0.023980259895324707,
0.001286819577217102,
0.05390140414237976
] | 2025-01-15 | 44 | 39809514 | [
"CAR T cell therapies",
"T cell therapy",
"unleashing IL-18",
"remarkable efficacy",
"IL-18",
"hyperinflammatory conditions",
"first clinical trials",
"cytokine help",
"solid cancer",
"Chimeric antigen receptor",
"CAR",
"expectations",
"first",
"a powerful driver",
"what extent",
"a double-edged sword",
"we"
] | [
"Adoptive cell therapy - ACT",
"Chimeric antigen receptor - CAR",
"Cytokine",
"Immune related adverse event - irAE",
"T cell"
] | 0 | 10.1136/jitc-2024-010545
10.1056/NEJMoa1709866
10.1172/JCI1555
10.1038/s41586-020-2422-6
10.1111/imr.12616
10.1084/jem.20160880
10.1158/2326-6066.CIR-23-0706
10.1200/JCO.2024.42.16_suppl.7004
10.1016/j.celrep.2017.09.002
10.1016/j.celrep.2018.04.051
10.1080/2162402X.2017.1378842
10.1136/ard-2024-225727
10.1002/art.42933
10.1016/S0140-6736(23)01126-1
10.1126/scitranslmed.3005930
10.1056/NEJMoa2308917
10.1182/blood-2017-06-789552
10.1182/blood-2017-12-820852
10.1172/JCI43157
10.1073/pnas.1820704116
10.1016/S2665-9913(21)00115-6
10.1016/j.bbmt.2018.12.758
10.1158/1078-0432.CCR-22-0822
10.1182/blood.2024024104
10.1182/blood.2021011898
10.1097/00002371-200003000-00002
10.4049/jimmunol.169.8.4467
10.1158/1078-0432.CCR-07-4740
10.1158/1078-0432.CCR-15-1655
10.1182/bloodadvances.2023010502
10.1182/blood.2019003846
10.1002/art.38793
10.1038/s41435-020-0098-4
10.1056/NEJMoa1215134
10.1002/art.41103
10.1056/NEJMoa1911326
10.1038/s41467-023-38723-y
10.1182/bloodadvances.2023010712
10.1182/bloodadvances.2022006983
10.1186/s13054-020-02878-7
10.1164/rccm.201903-0659OC
10.1172/JCI165616
10.1182/blood.2019000761
10.1182/bloodadvances.2017007526
10.1038/s41598-022-10777-w
10.1038/s41467-022-34480-6 | [
"Kessel",
"Rossig",
"Abken"
] | [
"Translational Inflammation Research, Department of Pediatric Rheumatology & Immunology, University of Münster Faculty of Medicine, Munster, Germany.",
"Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Munster, Germany.\nPrinses Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.",
"Division Genetic Immunotherapy, Leibniz Institute for Immunotherapy, Regensburg, Germany [email protected].\nUniversitätsklinikum Regensburg, Regensburg, Germany."
] | [
"39809514",
"29385370",
"9502787",
"29247988",
"28264883",
"38592331",
"28954221",
"29768210",
"29296541",
"38777374",
"38924652",
"37748491",
"38381673",
"29295842",
"29326099",
"21576823",
"30674681",
"38287622",
"30592986",
"35705524",
"38781564",
"34525183",
"9469432",
"10746544",
"12370382",
"18519778",
"26755531",
"37738167",
"32589707",
"25047945",
"32291394",
"23527958",
"31513353",
"32374962",
"37296093",
"37721859",
"35395068",
"32321563",
"31710506",
"37751296",
"31015190",
"29296794",
"35504889",
"36443301"
] | [] | 7.804799 | 5.34498 |
39806516 | 33 | Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition. | The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges. A critical process induced by TME signaling is the epithelial-mesenchymal transition (EMT), wherein epithelial cells acquire mesenchymal traits, which enhance their motility and invasiveness and promote metastasis and cancer progression. By targeting various components of the TME, novel investigational strategies aim to disrupt the TME's contribution to the EMT, thereby improving treatment efficacy, addressing therapeutic resistance, and offering a nuanced approach to cancer therapy. This review scrutinizes the key players in the TME and the TME's contribution to the EMT, emphasizing avenues to therapeutically disrupt the interactions between the various TME components. Moreover, the article discusses the TME's implications for resistance mechanisms and highlights the current therapeutic strategies toward TME modulation along with potential caveats. | [
0.008961652405560017,
0.021266866475343704,
0.039736058562994,
0.051358912140131,
-0.015023278072476387,
0.022324522957205772,
0.04628670960664749,
0.010877945460379124,
-0.03480032458901405,
0.01270325668156147,
0.0059365262277424335,
-0.019299397245049477,
0.008398706093430519,
-0.03354933485388756,
0.012907964177429676,
0.014238564297556877,
0.03414071351289749,
0.008319097571074963,
0.046013765037059784,
0.06118488684296608,
0.03348109871149063,
-0.014875433407723904,
-0.038121141493320465,
0.00035948253935202956,
-0.05167734622955322,
0.020664114505052567,
-0.018412329256534576,
0.05308755487203598,
0.019447240978479385,
0.029136743396520615,
0.04862947389483452,
-0.013306006789207458,
-0.03457287326455116,
0.0030791463796049356,
-0.03957683965563774,
-0.001489817863330245,
0.0019290867494419217,
0.004125430714339018,
0.00421356875449419,
0.027544571086764336,
0.01700212061405182,
0.04182862862944603,
-0.023541396483778954,
0.05604444816708565,
-0.05286010354757309,
-0.054770708084106445,
-0.03671093285083771,
-0.05558954179286957,
0.02927321568131447,
0.013101299293339252,
0.015933090820908546,
-0.00725006777793169,
0.02208569645881653,
0.02113039419054985,
-0.05631738901138306,
-0.024792389944195747,
-0.04003174602985382,
0.013999738730490208,
-0.021880989894270897,
0.018275856971740723,
-0.04433061182498932,
-0.001310698571614921,
-0.011059907265007496,
0.0012047906639054418,
-0.045558858662843704,
-0.019219787791371346,
-0.011355596594512463,
-0.008921848610043526,
-0.017024865373969078,
-0.025019841268658638,
0.00815988052636385,
-0.015330339781939983,
-0.025474747642874718,
0.011884424835443497,
0.027840260416269302,
-0.05349697172641754,
-0.017297809943556786,
0.039736058562994,
-0.0071306549943983555,
-0.05663582310080528,
0.049175363034009933,
-0.0371885821223259,
0.03762074559926987,
0.0054958355613052845,
-0.022460995241999626,
-0.01695662923157215,
-0.0018423701403662562,
-0.019777048379182816,
-0.06095743551850319,
-0.012282468378543854,
-0.025110824033617973,
-0.0022361483424901962,
-0.013601696118712425,
0.07587835937738419,
0.011298732832074165,
0.013965620659291744,
-0.007494580000638962,
-0.06045703589916229,
0.03555092215538025,
0.05167734622955322,
0.05472521856427193,
-0.002557425992563367,
-0.04335256293416023,
-0.02790849655866623,
0.032252851873636246,
-0.02495160698890686,
-0.03764348849654198,
-0.066279835999012,
0.0075116390362381935,
-0.0020072737243026495,
0.05495266988873482,
0.036074064671993256,
0.02067548781633377,
0.045740820467472076,
0.02117588371038437,
-0.0589558444917202,
-0.02249511331319809,
0.02305237203836441,
0.0010427304077893496,
0.015205240808427334,
-0.028886545449495316,
0.052951082587242126,
0.0056578959338366985,
-0.021062158048152924,
0.03038773499429226,
-0.060411546379327774,
0.05963820591568947,
0.026361815631389618,
-0.052086763083934784,
-0.00783007312566042,
0.020732350647449493,
0.03107009455561638,
0.014795824885368347,
-0.02123274840414524,
-0.03172970935702324,
-0.021664908155798912,
-0.04501296952366829,
0.05126792937517166,
-0.00016214919742196798,
-0.01956096664071083,
-0.051631856709718704,
0.016808785498142242,
0.021391965448856354,
-0.027339864522218704,
-0.0013512136647477746,
-0.07023751735687256,
-0.015046022832393646,
0.047583192586898804,
0.004904457833617926,
0.007403598632663488,
0.0018565859645605087,
0.0057744658552110195,
0.03298070281744003,
0.002598651684820652,
0.025247294455766678,
-0.0349140539765358,
-0.0007712082006037235,
0.06305000185966492,
-0.02586141787469387,
-0.026702994480729103,
-0.02654377743601799,
0.007517325226217508,
-0.018378211185336113,
0.011253242380917072,
0.05599895492196083,
0.021926479414105415,
-0.027157900854945183,
0.02158530056476593,
-0.052268724888563156,
-0.00956440344452858,
-0.026702994480729103,
-0.07533247023820877,
-0.0693277046084404,
0.015876227989792824,
-0.04069136083126068,
-0.00036783432005904615,
-0.023996302857995033,
0.0011237604776397347,
0.006425550207495689,
-0.0021750202868133783,
-0.030478717759251595,
0.06587041914463043,
-0.015091514214873314,
0.019162924960255623,
0.0004079940263181925,
0.035664647817611694,
-0.034982290118932724,
0.043784722685813904,
-0.04030469059944153,
-0.027544571086764336,
-0.022279031574726105,
0.02133510261774063,
0.024201011285185814,
-0.011327165178954601,
-0.007142027840018272,
0.013601696118712425,
0.012066387571394444,
0.03709760308265686,
0.0009290038142353296,
0.04166940972208977,
0.06896378099918365,
-0.01237344928085804,
0.017946049571037292,
-0.0013206496369093657,
-0.02631632424890995,
0.0009659649222157896,
-0.007386539597064257,
0.041737645864486694,
0.011952660977840424,
0.043307073414325714,
0.04075959697365761,
0.002651250222697854,
0.00923459604382515,
0.00783007312566042,
0.00770497415214777,
-0.008609100244939327,
-0.05922878906130791,
-0.012521293945610523,
0.027953987941145897,
0.017024865373969078,
-0.0018167817033827305,
0.03696113079786301,
0.04474002867937088,
0.02881830930709839,
-0.02476964332163334,
-0.011628540232777596,
0.004813476465642452,
-0.04671886935830116,
-0.00949048064649105,
-0.017650362104177475,
-0.011952660977840424,
-0.002618554048240185,
0.011145202443003654,
-0.011179320514202118,
-0.019674694165587425,
-0.03143401816487312,
-0.02633907087147236,
-0.030888132750988007,
0.0306151881814003,
-0.028659092262387276,
0.0566813163459301,
0.02993282862007618,
-0.011639912612736225,
0.011401087045669556,
-0.03081989660859108,
0.04121450334787369,
0.0038183690048754215,
-0.06182175502181053,
-0.02790849655866623,
-0.00561809167265892,
0.012055015191435814,
0.04417139291763306,
0.006846338510513306,
-0.013465223833918571,
0.03216186910867691,
-0.005982016678899527,
0.00618672464042902,
-0.004949948284775019,
0.021528437733650208,
0.026930447667837143,
0.0256794560700655,
0.030069300904870033,
-0.04626396298408508,
-0.0387125201523304,
-0.028727328404784203,
0.020300190895795822,
0.019322142004966736,
-0.03909919038414955,
0.03536896035075188,
-0.0019390378147363663,
0.06764455139636993,
0.0210052952170372,
-0.005817113444209099,
-0.023973558098077774,
-0.045285914093256,
0.01920841448009014,
0.0056152488104999065,
0.012339331209659576,
0.019754301756620407,
-0.016888393089175224,
0.01601269841194153,
-0.030001064762473106,
0.02196059748530388,
-0.029500668868422508,
-0.04480826109647751,
-0.024564936757087708,
-0.010195585899055004,
0.030183028429746628,
0.0008344685775227845,
-0.050267137587070465,
0.04066861793398857,
0.02014097385108471,
-0.019140178337693214,
0.005464560817927122,
-0.022335896268486977,
0.012191486544907093,
0.043943941593170166,
-0.04790162667632103,
-0.04221529886126518,
0.03782545402646065,
-0.039258405566215515,
-0.027044175192713737,
-0.06273157149553299,
-0.0029739495366811752,
0.009393813088536263,
-0.010218330658972263,
0.02088019624352455,
-0.0366881862282753,
0.03573288396000862,
0.023950813338160515,
0.045103952288627625,
-0.018162131309509277,
0.025270041078329086,
0.039667822420597076,
0.013522087596356869,
0.03762074559926987,
0.03502777963876724,
0.00332081550732255,
-0.003494248492643237,
-0.04492199048399925,
-0.05154087394475937,
-0.009331263601779938,
-0.027976732701063156,
0.011054221540689468,
0.03934938833117485,
-0.03530072420835495,
-0.008626159280538559,
0.0256794560700655,
-0.0026739956811070442,
-0.035619158297777176,
0.027840260416269302,
-0.011941288597881794,
0.07983604073524475,
-0.029295960441231728,
-0.010451470501720905,
-0.0023271297104656696,
-0.005953585263341665,
0.015614655800163746,
0.026884958148002625,
0.05572601035237312,
-0.02218805067241192,
-0.01496641431003809,
-0.024382973089814186,
0.03982704132795334,
0.011759325861930847,
0.014898179098963737,
-0.021994715556502342,
-0.003340717637911439,
0.03107009455561638,
0.05304206535220146,
0.010565197095274925,
0.019742930307984352,
0.019742930307984352,
-0.020482152700424194,
-0.0014727589441463351,
-0.017252318561077118,
-0.022210795432329178,
-0.015853481367230415,
0.05104047805070877,
-0.027840260416269302,
0.01639936864376068,
-0.05913781002163887,
-0.0011927072191610932,
0.047810643911361694,
0.02631632424890995,
0.07383128255605698,
-0.026634758338332176,
0.013681304641067982,
-0.04164666309952736,
-0.0655519887804985,
0.0026612014044076204,
0.025361021980643272,
0.0038354280404746532,
-0.015569165349006653,
-0.03393600508570671,
0.05331500992178917,
-0.02282491885125637,
0.0031104213558137417,
-0.00013576107448898256,
0.030956368893384933,
0.03038773499429226,
-0.01774134300649166,
0.03127480298280716,
-0.0011258928570896387,
-0.032480303198099136,
0.02363237738609314,
0.04292040318250656,
-0.05167734622955322,
-0.07701562345027924,
0.024860624223947525,
0.04430786520242691,
-0.02383708581328392,
-0.0034402282908558846,
0.007272813003510237,
0.015102886594831944,
0.01842370256781578,
-0.03682465851306915,
0.0468098483979702,
0.05891035497188568,
-0.025019841268658638,
-0.01667231321334839,
-0.035209741443395615,
-0.02747633494436741,
-0.0280904583632946,
0.02003861963748932,
-0.038371339440345764,
0.0101842125877738,
-0.025520239025354385,
0.02834065817296505,
-0.031229311600327492,
0.012930708937346935,
-0.02193785272538662,
0.027385354042053223,
0.05326951667666435,
-0.004389844834804535,
-0.013692677021026611,
-0.005930840037763119,
0.017752714455127716,
0.010912062600255013,
0.00421356875449419,
-0.009570089168846607,
-0.0132832620292902,
0.019447240978479385,
0.02272256650030613,
0.0047964174300432205,
0.02047077938914299,
0.048038095235824585,
-0.015262103639543056,
-0.015671519562602043,
-0.0571817122399807,
-0.008580668829381466,
0.04430786520242691,
-0.02611161768436432,
0.0069714379496872425,
-0.013556205667555332,
-0.02426924742758274,
-0.0004108371795155108,
-0.01236207690089941,
-0.05527110770344734,
0.0012268251739442348,
-0.02280217409133911,
0.010997357778251171,
-0.017673106864094734,
-0.01180481631308794,
0.07578737288713455,
0.05336049944162369,
0.027521826326847076,
0.006317510269582272,
-0.0023598261177539825,
-0.020743723958730698,
0.02904576249420643,
-0.01169108971953392,
0.031343039125204086,
0.011531872674822807,
0.014773079194128513,
-0.010684609413146973,
0.026680249720811844,
-0.009240282699465752,
0.030364990234375,
-0.026702994480729103,
0.009342636913061142,
-0.007540070451796055,
0.01482994295656681,
-0.008950280025601387,
-0.01697937399148941,
-0.002264579990878701,
0.008631845936179161,
-0.00022460994659923017,
-0.007869877852499485,
0.0015722695970907807,
0.0107528455555439,
-0.018833117559552193,
0.017946049571037292,
-0.021755890920758247,
0.01586485467851162,
0.002204873599112034,
0.0035539548844099045,
0.016240151599049568,
0.036983877420425415,
0.008938907645642757,
-0.00011808014824055135,
-0.017138591036200523,
-0.09380166232585907,
-0.0011315792798995972,
-0.004728181753307581,
0.025247294455766678,
-0.07683365792036057,
0.03056969866156578,
-0.0046372003853321075,
0.02077784202992916,
0.008961652405560017,
-0.02406453900039196,
0.03830310329794884,
-0.009001457132399082,
0.028659092262387276,
0.016126425936818123,
-0.026225343346595764,
-0.025156313553452492,
-0.004088469780981541,
0.004173764493316412,
-0.0011642755707725883,
0.02633907087147236,
0.0030336559284478426,
0.021801380440592766,
0.00827360711991787,
0.05827348679304123,
0.0016021227929741144,
0.038325849920511246,
0.023541396483778954,
0.020129600539803505,
-0.05909231677651405,
-0.026589268818497658,
0.05781858041882515,
0.025270041078329086,
0.03357207775115967,
0.007278499659150839,
-0.012680510990321636,
-0.0037899373564869165,
0.04817456752061844,
0.0016717803664505482,
-0.011656971648335457,
0.009274400770664215,
0.002611445961520076,
0.0011656972346827388,
0.020584506914019585,
-0.03825761377811432,
-0.04546787589788437,
0.01261227484792471,
-0.023655124008655548,
-0.02770378813147545,
0.024246500805020332,
-0.029750866815447807,
0.0022361483424901962,
0.029568905010819435,
-0.01134990993887186,
-0.005163185764104128,
-0.03125205636024475,
-0.013544832356274128,
-0.026361815631389618,
-0.010582256130874157,
0.026862211525440216,
-0.0022361483424901962,
-0.012111878022551537,
-0.00008955966040957719,
-0.02449670061469078,
0.06009311228990555,
0.008899102918803692,
-0.01999312825500965,
0.024019047617912292,
-0.007693601306527853,
0.027089664712548256,
-0.036756422370672226,
0.026270834729075432,
0.01945861428976059,
0.000815988052636385,
0.017161337658762932,
0.0017826637485995889,
-0.02970537543296814,
0.008990083821117878,
0.006653003394603729,
-0.041510194540023804,
0.018855862319469452,
0.017138591036200523,
-0.020607251673936844,
-0.015273476019501686,
0.021664908155798912,
-0.01258953008800745,
-0.013476597145199776,
-0.008398706093430519,
0.0240417942404747,
0.025270041078329086,
-0.017036238685250282,
0.008068898692727089,
-0.01415895577520132,
0.041055288165807724,
-0.02069823257625103,
-0.00877968966960907,
-0.013010318391025066,
-0.028431639075279236,
0.0058910357765853405,
0.002605759771540761,
0.007215949706733227,
-0.008694395422935486,
0.006550649646669626,
0.009871465153992176,
0.017275063320994377,
-0.0023228649515658617,
-0.011656971648335457,
-0.008506746031343937,
0.018082521855831146,
0.016968002542853355,
-0.016456233337521553,
0.029750866815447807,
0.002281639026477933,
0.026361815631389618,
0.006982810329645872,
0.008631845936179161,
-0.019492732360959053,
-0.025042587891221046,
0.013749540783464909,
0.010792650282382965,
0.004765142686665058,
-0.005726132076233625,
-0.04317060112953186,
-0.008796748705208302,
0.03236657753586769,
0.017923304811120033,
-0.011190692894160748,
0.031820688396692276,
0.0035425822716206312,
0.04139646515250206,
0.03596033528447151,
-0.016786038875579834,
-0.0361877903342247,
0.02080058678984642,
0.00048440403770655394,
0.0005206543719395995,
0.005791524890810251,
0.012680510990321636,
0.015933090820908546,
-0.0032156184315681458,
-0.009297145530581474,
-0.006010448560118675,
-0.03739329054951668,
-0.0012737374054268003,
-0.031615983694791794,
-0.014170329086482525,
-0.008256548084318638,
0.033390115946531296,
0.01741153560578823,
0.013681304641067982,
-0.033162664622068405,
-0.0029170862399041653,
0.015876227989792824,
0.008819494396448135,
0.025474747642874718,
0.016228780150413513,
-0.006158292759209871,
-0.03145676478743553,
-0.028226930648088455,
0.01784369722008705,
0.0037416035775095224,
0.001096039661206305,
0.018253112211823463,
-0.003434541868045926,
0.019526850432157516,
-0.006709866691380739,
0.043329816311597824,
0.012907964177429676,
-0.008557923138141632,
0.005239950958639383,
0.00022141139197628945,
0.031343039125204086,
0.014454645104706287,
0.01551230251789093,
0.00979185663163662,
0.023882577195763588,
-0.0037501330953091383,
0.03302619233727455,
0.0223927590996027,
-0.03132029250264168,
0.05877388268709183,
-0.025156313553452492,
-0.002581592882052064,
-0.026839466765522957,
0.012748747132718563,
-0.032707758247852325,
-0.024155519902706146,
0.018514683470129967,
0.009086751379072666,
0.05427031219005585,
0.005578287411481142,
0.043307073414325714,
0.01809389516711235,
0.047765154391527176,
0.024473953992128372,
-0.013158162124454975,
-0.010860886424779892,
-0.043489035218954086,
-0.003170127747580409,
0.0163197610527277,
0.0004964874824509025,
0.00921185128390789,
0.038826245814561844,
0.01181618869304657,
-0.013920130208134651,
0.0038212123326957226,
0.006795161869376898,
0.00008822693052934483,
-0.02856811136007309,
0.01609230786561966,
-0.015023278072476387,
0.013556205667555332,
-0.01227109506726265,
-0.00034100195625796914,
-0.011020103469491005,
-0.01978841982781887,
-0.003016596892848611,
-0.013840521685779095,
-0.030183028429746628,
0.04273843765258789,
0.017320554703474045,
-0.039918020367622375,
-0.009638325311243534,
-0.0016390839591622353,
-0.019572339951992035,
0.009837347082793713,
0.011167948134243488,
0.04953928664326668,
-0.0251790601760149,
-0.03975880518555641,
0.004432492423802614,
0.002686789957806468,
-0.0016262897988781333,
-0.012168741784989834,
0.001651878235861659,
-0.013999738730490208,
0.03232108801603317,
0.007403598632663488,
0.010553824715316296,
0.00872851349413395,
0.005970644298940897,
-0.0032696384005248547,
-0.010167154483497143,
0.02082333154976368,
0.001579377567395568,
-0.023336689919233322,
0.03143401816487312,
-0.005797211080789566,
-0.0016177602810785174,
-0.024883370846509933,
0.003465816844254732,
-0.0010093231685459614,
-0.002277374267578125,
0.005637994036078453,
0.013101299293339252,
-0.009541657753288746,
-0.03636975213885307,
-0.011435205116868019,
0.02327982522547245,
-0.00004740087388199754,
-0.03557366505265236,
-0.02815869450569153,
-0.014989160001277924,
0.0069714379496872425,
0.03559641167521477,
0.009393813088536263,
0.010633433237671852,
0.025997890159487724,
-0.026043381541967392,
0.010678923688828945,
0.0073069310747087,
-0.019515477120876312,
-0.007869877852499485,
0.021755890920758247,
-0.006249274127185345,
0.011003044433891773,
-0.001579377567395568,
0.0003003091842401773,
0.013089926913380623,
-0.0010924857342615724,
0.01258953008800745,
-0.02904576249420643,
0.0105026476085186,
0.0013526352122426033,
0.028636347502470016,
0.005987703334540129,
0.04223804175853729,
0.027317117899656296,
0.010849513113498688,
-0.010872258804738522,
-0.019970383495092392,
0.03757525235414505,
-0.024860624223947525,
0.006124175153672695,
-0.00519446050748229,
-0.019447240978479385,
0.025156313553452492,
0.019140178337693214,
-0.0024792389012873173,
-0.012089133262634277,
0.0018537428695708513,
-0.005183087661862373,
-0.026225343346595764,
-0.0028772817458957434,
0.01062774658203125,
-0.0024294834583997726,
0.028386147692799568,
-0.01755937933921814,
0.009172046557068825,
-0.0023370806593447924,
0.027112411335110664,
-0.0326395221054554,
0.024360228329896927,
-0.011099711991846561,
0.011105397716164589,
0.036779168993234634,
-0.08142821490764618,
0.003170127747580409,
0.019924892112612724,
0.0028005163185298443,
0.011219124309718609,
0.004742397461086512,
0.0065335906110703945,
0.025315530598163605,
0.02699868381023407,
-0.00696575129404664,
0.002338502323254943,
0.006323196459561586,
0.03614230081439018,
0.0010626325383782387,
-0.01677466742694378,
-0.01040029339492321,
-0.027317117899656296,
-0.0074092852883040905,
-0.012907964177429676,
0.021300984546542168,
-0.0025872790720313787,
0.03172970935702324,
-0.020106855779886246,
0.05986565724015236,
-0.02856811136007309,
-0.0013000366743654013,
0.018617037683725357,
-0.01788918673992157,
-0.00971793383359909,
-0.05558954179286957,
-0.0521322526037693,
0.03818937763571739,
-0.020516270771622658,
0.028181441128253937,
-0.03243481367826462,
-0.023473160341382027,
0.02426924742758274,
0.01283972803503275,
-0.022381385788321495,
-0.018867235630750656,
0.013419733382761478,
0.020004501566290855,
0.02740810066461563,
0.05022164806723595,
-0.009501853957772255,
-0.03468659892678261,
-0.05222323536872864,
-0.017070356756448746,
-0.015159749425947666,
-0.0065790810622274876,
-0.01131010614335537,
-0.017491145059466362,
-0.014875433407723904,
-0.012953454628586769,
0.012430312111973763,
-0.006004761904478073,
0.016740549355745316,
0.02385983057320118,
0.04003174602985382,
0.004276118706911802,
-0.037006620317697525,
-0.009149301797151566,
0.023950813338160515,
-0.04000900313258171,
-0.026702994480729103,
-0.007841446436941624,
-0.0034117966424673796,
0.03828035667538643,
-0.03220735862851143,
0.018253112211823463,
0.004876025952398777,
0.0006805823650211096,
-0.05381540581583977,
0.038325849920511246,
-0.0005366471596062183,
-0.02925047092139721,
-0.019185669720172882,
0.0280904583632946,
-0.0034316987730562687,
0.006943006068468094,
-0.05126792937517166,
-0.010258135385811329,
0.00804615393280983,
0.041965097188949585,
0.0004392688279040158,
-0.01305580884218216,
-0.021653536707162857,
0.00785850454121828,
0.029819102957844734,
-0.004927203059196472,
0.026407307013869286,
-0.028727328404784203,
-0.015614655800163746,
0.00398611556738615,
0.044853754341602325,
-0.008967339061200619,
-0.011782071553170681,
0.007926740683615208,
0.03218461573123932,
-0.002391100861132145,
0.030183028429746628,
-0.021721772849559784,
0.0010974612087011337,
-0.00519446050748229,
0.0022944333031773567,
0.019572339951992035,
-0.005711916368454695,
0.005953585263341665,
0.0025147784035652876,
0.009245969355106354,
0.013465223833918571,
-0.025247294455766678,
0.016058189794421196,
-0.02292727306485176,
0.0184691920876503,
-0.018025659024715424,
0.029136743396520615,
-0.004722495097666979,
0.004901614505797625,
-0.02902301773428917,
0.04699181392788887,
0.01005911361426115,
-0.021073531359434128,
-0.018617037683725357,
-0.0027422315906733274,
-0.009848719462752342,
0.017752714455127716,
0.013124044053256512,
-0.004893084987998009,
0.00017627616762183607,
0.030979113653302193,
-0.00392925227060914,
0.001684574643149972,
0.013487969525158405,
-0.0223927590996027,
0.04749220982193947,
-0.004597396124154329,
0.05963820591568947,
0.045968275517225266,
-0.00421356875449419,
0.028249677270650864,
-0.014534253627061844,
-0.04228353500366211,
0.013010318391025066,
0.016820156946778297,
-0.0146138621494174,
-0.030637934803962708,
-0.03377678617835045,
0.009843033738434315,
-0.02381434105336666,
0.03555092215538025,
0.018002914264798164,
0.01508014090359211,
0.021346474066376686,
0.0037529764231294394,
-0.011548931710422039,
0.020072737708687782,
0.00702261459082365,
-0.03780270740389824,
0.019856655970215797,
0.0037558195181190968,
0.03236657753586769,
-0.02292727306485176,
-0.018537428230047226,
-0.015205240808427334,
-0.02234726771712303,
-0.0031530687119811773,
0.011509126983582973,
0.03200265392661095,
-0.00827360711991787,
0.013749540783464909,
-0.0371885821223259,
0.03716583922505379,
-0.027339864522218704,
-0.021164512261748314,
0.04166940972208977,
-0.006982810329645872,
-0.0032952269539237022,
-0.004659945610910654,
-0.020664114505052567,
-0.031388528645038605,
0.021073531359434128,
-0.0005171004449948668,
0.028636347502470016,
0.011429518461227417,
-0.05531659722328186,
0.0006048831273801625,
-0.04949379712343216,
-0.03254853934049606,
0.002415267750620842,
0.00024024734739214182,
-0.011571677401661873,
0.031115585938096046,
0.029591649770736694,
0.016717802733182907,
-0.003681897185742855,
-0.016638195142149925,
0.02747633494436741,
-0.01576250046491623,
0.005782995373010635,
-0.05081302672624588,
0.021892361342906952,
0.046445924788713455,
-0.02224491350352764,
0.0031729708425700665,
-0.0018423701403662562,
0.04862947389483452,
-0.029091252014040947,
-0.030910877510905266,
0.048038095235824585,
-0.00036392497713677585,
0.04417139291763306,
-0.03329913690686226,
0.005484463181346655,
0.011116771027445793,
-0.011475009843707085,
0.004051508381962776,
-0.01900370791554451,
-0.027794770896434784,
0.006618885323405266,
-0.021892361342906952,
-0.04651416093111038,
0.03279873728752136,
-0.0032412067521363497,
-0.013840521685779095,
0.03739329054951668,
0.014363664202392101,
0.003585229627788067,
-0.009877150878310204,
0.013271888718008995,
-0.0256794560700655,
0.02586141787469387,
0.00725006777793169,
0.0011536137899383903,
0.002902870299294591,
0.036779168993234634,
0.0011365547543391585,
-0.021414710208773613,
0.016592703759670258,
0.010417352430522442,
0.03591484576463699,
0.05800054222345352,
-0.010713041760027409,
-0.05649935454130173,
-0.0062094698660075665,
0.0005604586913250387,
0.06678023189306259,
-0.02065274305641651,
-0.023473160341382027,
-0.03354933485388756,
-0.013749540783464909,
0.04476277157664299,
0.003747290000319481,
0.01844644732773304,
0.04360276088118553,
0.01854880154132843,
-0.008535178378224373,
-0.00719320448115468,
0.013988366350531578,
-0.0229045283049345,
0.023336689919233322,
-0.016797412186861038,
-0.007767523638904095,
0.022404130548238754,
-0.015444066375494003,
0.009700874797999859,
-0.0029170862399041653,
-0.014249937608838081,
-0.016251524910330772,
-0.007960858754813671,
-0.018059777095913887,
0.03352658823132515,
-0.024815134704113007,
-0.0016817314317449927,
0.03145676478743553,
-0.006408491171896458,
0.006175351794809103,
-0.021164512261748314,
-0.020482152700424194,
-0.009166359901428223,
0.0011280252365395427,
-0.013942875899374485,
0.021096276119351387,
-0.0010228281607851386,
0.002325708046555519,
0.019572339951992035,
0.0017513890052214265,
0.006181038450449705,
0.01508014090359211,
-0.017036238685250282,
-0.0005014630150981247,
0.012396194972097874,
-0.011617167852818966,
-0.027999477460980415,
0.04085057973861694,
-0.024360228329896927,
0.013328752480447292,
0.009160674177110195,
-0.0021010981872677803,
-0.030706169083714485,
-0.002708113519474864,
0.019981754943728447,
-0.0427611842751503,
0.015694264322519302,
-0.0013967042323201895,
-0.005046615842729807,
-0.04694632068276405,
-0.018810372799634933,
-0.018059777095913887,
0.0110712805762887,
-0.04876594617962837,
-0.00026672432431951165,
0.032048143446445465,
0.023564143106341362,
0.021119020879268646,
0.0027706632390618324,
0.01786644198000431,
0.006522217765450478,
0.02565671131014824,
0.017343299463391304,
0.016456233337521553,
0.004526317119598389,
0.014215819537639618,
0.005970644298940897,
-0.0432615801692009,
-0.003246893174946308,
0.025702200829982758,
-0.024473953992128372,
-0.0173319261521101,
-0.00015886178880464286,
-0.002395365620031953,
-0.0037814080715179443,
0.005114851985126734,
-0.01029793918132782,
0.0427611842751503,
0.017548007890582085,
0.02606612630188465,
-0.03193441778421402,
0.014136211015284061,
0.03309442847967148,
-0.005359363742172718,
0.009064006619155407,
-0.011941288597881794,
0.02449670061469078,
0.003027969505637884,
0.002897184109315276,
-0.0011067015584558249,
0.013760913163423538,
0.016467604786157608,
-0.03937213495373726,
0.048493001610040665,
-0.022768056020140648,
-0.011884424835443497,
0.02016371861100197,
0.047128286212682724,
0.014761706814169884,
-0.009808915667235851,
0.023655124008655548,
0.007602620404213667,
0.019981754943728447,
-0.027044175192713737,
0.029113998636603355,
0.0210052952170372,
-0.0344136543571949,
-0.004125430714339018,
0.002629926661029458,
-0.02179000712931156,
-0.013499341905117035,
-0.0036108181811869144,
0.004287491086870432,
0.00034668829175643623,
0.026475541293621063,
-0.041692156344652176,
0.012691883370280266,
-0.0026725740171968937,
0.010769904591143131,
0.020982548594474792,
0.01654721423983574,
-0.011457950808107853,
0.012202858924865723,
0.0007278499542735517,
0.011406773701310158,
-0.01807115040719509,
-0.006897515617311001,
-0.018435074016451836,
-0.004338668193668127,
-0.008648904971778393,
0.013942875899374485,
0.007795955520123243,
0.0012275360058993101,
0.026657504960894585,
-0.025815928354859352,
0.020379798486828804,
-0.013590323738753796,
0.004932889249175787,
0.006874770391732454,
-0.010673237033188343,
0.010991671122610569,
-0.029614394530653954,
0.0016817314317449927,
-0.021244119852781296,
-0.018844490870833397,
0.0051290676929056644,
0.009342636913061142,
0.009274400770664215,
0.01776408776640892,
0.04317060112953186,
0.02042528986930847,
-0.004486512392759323,
0.0029099781531840563,
0.000984445447102189,
0.009132242761552334,
-0.0566813163459301,
0.052268724888563156,
-0.010667551308870316,
-0.017627615481615067,
0.027157900854945183,
-0.01471621636301279,
0.002155118156224489,
-0.010053427889943123,
0.004105528816580772,
-0.01473896112293005,
0.04708279296755791,
-0.00838733371347189,
-0.003519836813211441,
0.018207620829343796,
-0.025724947452545166,
0.033162664622068405,
0.005501522216945887,
-0.005987703334540129,
0.014284055680036545,
0.04949379712343216,
-0.03268501162528992,
-0.01272600144147873,
-0.020300190895795822,
0.02811320498585701,
-0.009274400770664215,
-0.030274009332060814,
0.0032241479493677616,
0.015330339781939983,
0.0306151881814003,
0.03502777963876724,
0.017297809943556786,
0.012873846106231213,
0.03448189049959183,
-0.011031475849449635,
-0.011634226888418198,
-0.015796618536114693,
0.010673237033188343,
0.007966545410454273,
-0.019174296408891678,
-0.011600108817219734,
0.03489130735397339,
0.0234049241989851,
-0.02770378813147545,
-0.014693470671772957,
0.019754301756620407,
0.003141696099191904,
0.030888132750988007,
0.028659092262387276,
-0.04112352058291435,
-0.02449670061469078,
-0.01915155164897442,
-0.04294314607977867,
0.01654721423983574,
0.05349697172641754,
-0.005964957643300295,
0.009820288047194481,
-0.03573288396000862,
0.01650172285735607,
-0.005751720629632473,
0.011827562004327774,
0.007198891136795282,
-0.02117588371038437,
-0.004622984677553177,
-0.007045360282063484,
0.022438248619437218,
0.005029556807130575,
-0.0070851645432412624,
-0.006090057082474232,
-0.01755937933921814,
0.04025920107960701,
0.0003534408169798553,
-0.019879402592778206,
0.0099340146407485,
0.011668344959616661,
0.010354802943766117,
-0.01119637954980135,
0.026839466765522957,
-0.004051508381962776,
-0.004654259420931339,
0.0030052242800593376,
-0.016103679314255714,
-0.02065274305641651,
0.004079940263181925,
0.011560304090380669,
0.005026713944971561,
0.010792650282382965,
0.006419864017516375,
-0.012578156776726246,
0.006249274127185345,
0.033867768943309784,
0.0018253112211823463,
-0.011111084371805191,
-0.009712248109281063,
-0.013033063150942326,
-0.052541669458150864,
-0.03909919038414955,
0.010383234359323978,
0.0028815465047955513,
0.029295960441231728,
0.024587681517004967,
-0.03145676478743553,
0.028044968843460083,
0.04050939902663231,
-0.009979505091905594,
-0.01763898879289627,
0.060366056859493256,
-0.005777309183031321,
-0.015921717509627342,
-0.010678923688828945,
-0.014477390795946121,
0.020755097270011902,
-0.009183418937027454,
-0.01948135904967785,
-0.022813547402620316,
0.0052513238042593,
0.006624571979045868,
0.005982016678899527,
-0.009911268949508667,
0.06814495474100113,
0.01571700908243656,
0.009752051904797554,
-0.014977787621319294,
-0.01142383273690939,
0.043329816311597824,
0.004227784462273121,
-0.012418939732015133,
0.009911268949508667,
-0.019265279173851013,
-0.027271628379821777,
-0.03875800967216492,
-0.0016788882203400135,
-0.009734992869198322,
-0.015751127153635025,
0.00035983792622573674,
-0.014079347252845764,
-0.04346628859639168,
-0.015341712161898613,
0.017024865373969078,
0.014773079194128513,
-0.026407307013869286,
0.011520500294864178,
-0.012544038705527782,
-0.032093632966279984,
0.011361283250153065,
0.0023200216237455606,
0.01920841448009014,
-0.03621053695678711,
0.041487447917461395,
0.023234335705637932,
-0.024906115606427193,
-0.003494248492643237,
-0.015455438755452633,
0.0035653274971991777,
0.04369374364614487,
-0.013203653506934643,
-0.027339864522218704,
-0.02426924742758274,
0.003073460189625621,
-0.03848506510257721,
-0.015876227989792824,
-0.03411796689033508,
-0.004449551459401846,
-0.012464430183172226,
0.01854880154132843,
-0.03514150530099869,
-0.0005739636835642159,
-0.008466942235827446,
-0.050039682537317276,
-0.019515477120876312,
-0.0030962054152041674,
0.011213438585400581,
0.010485588572919369,
0.03327639028429985,
-0.004480826202780008,
0.009581462480127811,
-0.00078755640424788,
-0.008319097571074963,
-0.00934832263737917,
-0.027817515656352043,
-0.025292785838246346,
0.010548138059675694,
-0.010042054578661919,
-0.02740810066461563,
0.018685273826122284,
0.008216743357479572,
0.0009695189073681831,
-0.01945861428976059,
0.002148010302335024,
-0.0029284588526934385,
0.01933351531624794,
-0.005069361068308353,
-0.016717802733182907,
-0.008745572529733181,
0.002710956847295165,
0.013988366350531578,
-0.010224017314612865,
0.016911137849092484,
0.024587681517004967,
-0.0240417942404747,
0.0015054552350193262,
-0.008950280025601387,
-0.0025147784035652876,
0.02269981987774372,
0.03461836278438568,
-0.03168421983718872,
-0.0005110587226226926,
-0.012521293945610523,
0.039940766990184784,
0.0212554931640625,
0.006675748620182276,
-0.021517064422369003,
0.0012396194506436586,
-0.02185824327170849,
0.03548268601298332,
-0.008916161954402924,
-0.016638195142149925,
0.0339132584631443,
-0.017775461077690125,
-0.021517064422369003,
-0.015557792969048023,
0.01482994295656681,
-0.019447240978479385,
0.004708279389888048,
-0.024155519902706146,
-0.037029366940259933,
0.006573394872248173,
-0.02338217943906784,
0.03327639028429985,
0.0508585162460804,
0.01753663457930088,
-0.014056602492928505,
-0.011964033357799053,
-0.04387570545077324,
-0.0006233637104742229,
-0.027362609282135963,
-0.0356873944401741,
0.006397118791937828,
-0.0294779222458601,
-0.0189809612929821,
-0.004412590526044369,
-0.0014798667980358005,
0.008495373651385307,
0.005982016678899527,
-0.0038979777600616217,
-0.006380059756338596,
-0.011861680075526237,
0.01776408776640892,
-0.0037984668742865324,
0.007642424665391445,
-0.010081859305500984,
-0.02363237738609314,
-0.003698956221342087,
-0.0146138621494174,
-0.025702200829982758,
0.003951997961848974,
0.024155519902706146,
-0.015853481367230415,
0.0012246927944943309,
0.002614289289340377,
0.009916955605149269,
-0.019401749595999718,
0.02138059213757515,
0.11609207093715668,
-0.0637778490781784,
-0.012168741784989834,
-0.012544038705527782,
-0.009399499744176865,
-0.020084109157323837,
0.018037032335996628,
0.006783789023756981,
0.013692677021026611,
-0.01552367489784956,
0.020834704861044884,
0.01074147317558527,
0.026589268818497658,
0.028909290209412575,
0.02674848586320877,
-0.01677466742694378,
0.001570848049595952,
0.06004762277007103,
0.01551230251789093,
-0.00526269618421793,
0.006158292759209871,
0.026589268818497658,
0.013249143958091736,
0.024587681517004967,
-0.017627615481615067,
0.007346735335886478,
-0.01588759943842888,
-0.026248088106513023,
-0.011150889098644257,
-0.03739329054951668,
0.003511307295411825,
0.004685534164309502,
0.04114626720547676,
-0.041259992867708206,
0.02499709650874138,
-0.018537428230047226,
-0.00241953250952065,
0.0063118236139416695,
-0.019629202783107758,
0.0318889245390892,
0.005035243462771177,
0.04587729275226593,
0.016638195142149925,
0.004622984677553177,
0.021573927253484726,
0.009103810414671898,
-0.02672574110329151,
0.0012047906639054418,
-0.008398706093430519,
-0.000010289810234098695,
0.0018452133517712355,
-0.022984137758612633,
0.009058319963514805,
-0.017138591036200523,
-0.012066387571394444,
-0.005856917705386877,
0.0251790601760149,
-0.0029199293348938227,
-0.01768448017537594,
-0.0026000733487308025,
-0.0031957163009792566,
0.005575444549322128,
0.015853481367230415,
-0.02740810066461563,
0.0013249143958091736
] | 2025-01-14 | 1,159 | 39806516 | [
"TME",
"TME modulation",
"cancer cells",
"cancer progression",
"therapeutic resistance",
"cancer therapy",
"epithelial cells",
"diverse cell types",
"therapeutic challenges",
"extracellular matrix components",
"various components",
"resistance mechanisms",
"the various TME components",
"mesenchymal traits",
"EMT",
"treatment efficacy",
"tumor growth",
"metastasis and cancer progression",
"the TME, novel investigational strategies",
"the TME",
"the current therapeutic strategies",
"potential caveats",
"the TMEs contribution",
"the TMEs implications",
"molecules",
"avenues",
"metastasis and treatment response",
"the intricate interactions",
"The tumor microenvironment",
"the epithelial-mesenchymal transition"
] | [
"Cancer",
"Cancer-associated fibroblasts (CAFs)",
"Chimeric antigen-receptor (CAR) T-cell therapy",
"Dendritic cells (DCs)",
"Epithelial-mesenchymal transition (EMT)",
"Extracellular matrix (ECM)",
"Metastasis",
"Myeloid-derived suppressor cells (MDSCs)",
"Natural killer (NK) cells",
"T-cell receptor (TCR) therapy",
"T-cells, B-cells, tumor-associated macrophages (TAMs)",
"Theranostics",
"Tumor microenvironment (TME)",
"Tumor-associated neutrophils (TANs)"
] | 0 | 10.1186/s13045-024-01634-6 | [
"Glaviano",
"Lau",
"Carter",
"Lee",
"Lam",
"Okina",
"Tan",
"Tan",
"Ang",
"Carbone",
"Yee",
"Shanmugam",
"Huang",
"Sethi",
"Tan",
"Lim",
"Huang",
"Ungefroren",
"Giovannetti",
"Tang",
"Bruno",
"Luo",
"Andersen",
"Qian",
"Ishihara",
"Radisky",
"Elias",
"Yadav",
"Kim",
"Robert",
"Diana",
"Schalper",
"Shi",
"Merghoub",
"Krebs",
"Kusumbe",
"Davids",
"Brown",
"Kumar"
] | [
"Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123, Palermo, Italy.",
"Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, 169610, Singapore.\nDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.",
"Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.\nSchool of Chemical and Life Sciences, Singapore Polytechnic, Singapore, 139651, Singapore.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.\nSchool of Chemical and Life Sciences, Singapore Polytechnic, Singapore, 139651, Singapore.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.",
"Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123, Palermo, Italy.",
"Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, 169610, Singapore.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.",
"Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.",
"Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.",
"Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, 169610, Singapore.\nImmunology Program, Life Sciences Institute, National University of Singapore, Singapore, 117456, Singapore.\nImmunology Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore.",
"School of Medicine and Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.\nDepartment of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore.",
"First Department of Medicine, University Hospital Schleswig-Holstein (UKSH), Campus Lübeck, 23538, Lübeck, Germany.",
"Department of Medical Oncology, Cancer Center Amsterdam, UMC, Vrije Universiteit, HV Amsterdam, 1081, Amsterdam, The Netherlands.\nCancer Pharmacology Lab, Fondazione Pisana Per La Scienza, 56017, San Giuliano, Italy.",
"Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.\nExperimental Therapeutics (ET) Graduate Program, University at Buffalo & Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA.",
"Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.",
"Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.",
"National Center for Cancer Immune Therapy, Department of Oncology, Herlev and Gentofte Hospital, Herlev, Denmark.",
"Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, The Human Phenome Institute, Zhangjiang-Fudan International Innovation Center, Fudan University, Shanghai, China.",
"Department of Bioengineering, Imperial College London, London, W12 0BZ, UK.",
"Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, 32224, USA.",
"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.",
"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.",
"Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.",
"Department of Cancer Medicine, Inserm U981, Gustave Roussy Cancer Center, Université Paris-Saclay, Villejuif, France.\nFaculty of Medicine, University Paris-Saclay, Kremlin Bicêtre, Paris, France.",
"Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90123, Palermo, Italy.",
"Department of Pathology, Yale School of Medicine, Yale University, New Haven, CT, USA.",
"Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.",
"Swim Across America and Ludwig Collaborative Laboratory, Department of Pharmacology, Weill Cornell Medicine, New York, NY, USA.\nSandra and Edward Meyer Cancer Center, Department of Medicine, Parker Institute for Cancer Immunotherapy, Weill Cornell Medicine, New York, NY, USA.",
"Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Tissue and Tumor Microenvironment Group, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.",
"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.",
"Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.",
"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. [email protected].\nNUS Center for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore. [email protected]."
] | [
"39806516",
"35988567",
"36791168",
"38050068",
"19109576",
"38849014",
"35411083",
"38227149",
"30459476",
"19945376",
"30459476",
"30594349",
"36787696",
"38378518",
"32566256",
"33257838",
"24556840",
"27840647",
"20531305",
"38503384",
"25852822",
"26791236",
"23201165",
"23201163",
"38172210",
"37076857",
"36768876",
"30975895",
"34847378",
"29920274",
"34451837",
"36699696",
"36866237",
"38398019",
"36917948",
"37108403",
"38593779",
"24202395",
"38523155",
"38487526",
"38672455",
"30867580",
"31980749",
"35331673",
"36807417",
"36766851",
"36077421",
"33806335",
"36682706",
"33811125",
"36581713",
"36792751",
"33428453",
"36574773",
"36792571",
"36631610",
"35393541",
"36082430",
"32690952",
"36797782",
"36163047",
"36859354",
"36060811",
"35086885",
"36639382",
"36761758",
"33888679",
"36114508",
"36521658",
"36306939",
"35158804",
"20036812",
"32133288",
"35181473",
"35378273",
"24048067",
"38002286",
"27335258",
"32759677",
"34680284",
"38500662",
"12665527",
"23071104",
"38334836",
"29146722",
"28442746",
"28127051",
"31711497",
"34326502",
"38123660",
"18026916",
"32322559",
"18297062",
"26057751",
"29423039",
"12411310",
"20158611",
"16815840",
"20010940",
"32014012",
"28093071",
"36759842",
"38612842",
"30606227",
"32075803",
"36831295",
"37996700",
"30927908",
"37277751",
"37062850",
"36810872",
"37784082",
"38614376",
"24335925",
"29325547",
"30835040",
"26152796",
"29100297",
"29113334",
"30744595",
"24011634",
"27287412",
"12743039",
"19597490",
"28575585",
"29228645",
"29563996",
"30158543",
"28718374",
"37831111",
"27878234",
"31106200",
"34635121",
"38225927",
"38463229",
"36980785",
"25107915",
"25893917",
"28671675",
"27076520",
"38096955",
"36052235",
"34298680",
"30814494",
"35712024",
"28232471",
"30385653",
"34129825",
"33905375",
"35264742",
"29455927",
"35523176",
"35029648",
"31197017",
"29853174",
"36906534",
"35331296",
"31380370",
"38840117",
"35205794",
"37804773",
"21654799",
"32768952",
"26876920",
"27479603",
"22238361",
"33405954",
"24554436",
"29740072",
"30145835",
"31323325",
"29159332",
"35008401",
"11309315",
"16651417",
"17673689",
"21377268",
"20018240",
"28324731",
"8645562",
"30627897",
"15890231",
"25591736",
"16285938",
"29416721",
"18496706",
"35366585",
"32266654",
"32426283",
"37468964",
"23624917",
"23966293",
"28521486",
"22454420",
"28406574",
"12954618",
"29137675",
"38724670",
"23033492",
"23108409",
"27006892",
"29725394",
"35202638",
"15094123",
"34054795",
"35785162",
"11180164",
"21281808",
"23645740",
"34113398",
"36102918",
"36250005",
"37513440",
"38672151",
"32266655",
"20534975",
"18174174",
"21342370",
"21219539",
"16001073",
"26097889",
"37982191",
"36801000",
"37435084",
"38581685",
"29241546",
"25314079",
"34386431",
"23329645",
"37333017",
"38356443",
"26193342",
"31160735",
"38730579",
"26819959",
"32289253",
"32405062",
"34184758",
"23661553",
"29147615",
"31799175",
"32036601",
"30616627",
"30482778",
"33376096",
"38450975",
"38320755",
"35865534",
"30718830",
"20371344",
"29961579",
"32561858",
"33203697",
"37211559",
"38650924",
"31629410",
"30361552",
"31300030",
"35690521",
"37426676",
"28117416",
"38561369",
"38365757",
"38730724",
"35387972",
"23418320",
"32780802",
"31186031",
"30132555",
"29849939",
"31801938",
"30927925",
"28837884",
"30537992",
"32300100",
"29348500",
"31275327",
"29383101",
"21980263",
"29552012",
"27757311",
"31552179",
"34620838",
"37006306",
"36978204",
"37508575",
"38609997",
"31810551",
"38473341",
"34360810",
"28898680",
"26493961",
"30352680",
"36949244",
"32324088",
"38216551",
"38614099",
"38490195",
"16417215",
"36175673",
"32433532",
"22566933",
"31088844",
"32028908",
"37931287",
"38383621",
"28955340",
"35637393",
"38725070",
"34858978",
"32391271",
"30329167",
"29752261",
"26137395",
"34997230",
"26137395",
"31690033",
"30643426",
"30643426",
"37242707",
"37287924",
"34897815",
"33680573",
"38216964",
"38640983",
"38694824",
"36737375",
"30243489",
"27363026",
"29616188",
"30591649",
"28265569",
"27196940",
"28394344",
"30971292",
"32854710",
"37178752",
"37183560",
"37046817",
"38258348",
"38455764",
"38632250",
"31402274",
"32026462",
"30237408",
"28121625",
"31064356",
"32917852",
"38500820",
"33407563",
"34866540",
"34930899",
"34552063",
"30816272",
"38674070",
"37965341",
"31785429",
"33259885",
"33922795",
"35986950",
"37160171",
"38069096",
"37228619",
"37513975",
"38481527",
"21442098",
"25406520",
"31015673",
"34601124",
"37669923",
"38649750",
"38317886",
"38453888",
"38533507",
"37059073",
"37454231",
"35082367",
"37020537",
"35440724",
"38664743",
"38571495",
"34937915",
"38162657",
"38425643",
"35978433",
"37141735",
"38723627",
"35164813",
"38048058",
"38157864",
"38306161",
"38594286",
"18759926",
"32266087",
"29794465",
"36907978",
"31828774",
"36874131",
"29316433",
"36980583",
"28258692",
"32868929",
"30333036",
"28438889",
"33721562",
"25891174",
"25891173",
"25399552",
"29863979",
"35082923",
"37457376",
"34433653",
"29357948",
"35122038",
"37161048",
"23390376",
"20525992",
"34716198",
"38229100",
"38545758",
"38354701",
"37291608",
"26763253",
"35576957",
"36636263",
"27192565",
"38132831",
"38791963",
"16286920",
"26493689",
"37345075",
"37468979",
"28423646",
"28653573",
"37083373",
"33514524",
"36040436",
"38486998",
"38504015",
"38323282",
"31690319",
"28197366",
"26318293",
"32850194",
"35494015",
"35217575",
"34986285",
"36780608",
"35543970",
"34103659",
"35699599",
"35511938",
"30470934",
"37037613",
"38550594",
"38326614",
"38693513",
"38483840",
"36750830",
"37111779",
"37322053",
"24329789",
"33782566",
"37481703",
"38201467",
"38201551",
"38184565",
"38184303",
"21498393",
"36477031",
"36891310",
"36356599",
"33824268",
"37256141",
"37420216",
"36949949",
"37055515",
"37047272",
"38247837",
"35296095",
"38413984",
"38455066",
"38667277",
"30815512",
"31681259",
"30655315",
"17299405",
"32735779",
"27000958",
"30889381",
"21742772",
"23029447",
"36261831",
"36253762",
"35720364",
"38525009",
"33042849",
"37908719",
"29288199",
"34193217",
"35725570",
"36791198",
"35303904",
"29226910",
"26063792",
"27677755",
"36600556",
"34518197",
"21079151",
"33408343",
"23328583",
"34526675",
"32690770",
"34887574",
"37217243",
"35365796",
"36900307",
"37344597",
"38211334",
"38514660",
"38631710",
"36183125",
"37509309",
"37294973",
"36903645",
"34248972",
"37174062",
"26275952",
"37404752",
"37205115",
"36717905",
"34422667",
"25340009",
"32023374",
"37313405",
"36822672",
"27283985",
"38035101",
"38339310",
"32471499",
"21654748",
"24928772",
"27055731",
"31297636",
"23081697",
"25337873",
"35974096",
"36335744",
"37346794",
"37560003",
"38273373",
"38254773",
"33619259",
"26681456",
"31088236",
"24056773",
"38303927",
"38641704",
"32669424",
"28759044",
"28380350",
"26449250",
"31229240",
"31602563",
"27199435",
"34778245",
"38943828",
"32470396",
"33144684",
"28716061",
"34758832",
"37391734",
"18354158",
"31412220",
"31403344",
"21436454",
"29436396",
"23483678",
"33387490",
"11432896",
"33335026",
"38713256",
"31462760",
"35418166",
"28258703",
"22451919",
"36439116",
"35436123",
"28298418",
"34981142",
"34686340",
"34189494",
"36119485",
"38758808",
"34539652",
"32531244",
"32783918",
"32783915",
"35322259",
"37596643",
"27642729",
"37935952",
"37937690",
"27828943",
"37000164",
"35122833",
"26873574",
"29942309",
"29872554",
"17101732",
"32121014",
"29136508",
"28932631",
"25320361",
"27265504",
"27124439",
"34674757",
"38750338",
"38760815",
"27282249",
"31969717",
"36706760",
"28025976",
"28473638",
"36835665",
"31776331",
"38841190",
"35355992",
"31467405",
"36713392",
"18182579",
"27364892",
"18591558",
"19483646",
"35482127",
"34667029",
"17116643",
"25869209",
"26014293",
"34097779",
"34249005",
"27096321",
"33810248",
"33215306",
"29311386",
"31611878",
"33255895",
"37681880",
"35074008",
"37232942",
"32150821",
"31020037",
"31031762",
"34480145",
"31668803",
"37257227",
"29651130",
"37394578",
"37007004",
"38525013",
"38509063",
"38455762",
"38555315",
"36324128",
"36632455",
"24780757",
"30996350",
"30470818",
"27216177",
"32434947",
"16794736",
"23732988",
"24778279",
"25979873",
"12738716",
"12624517",
"36672284",
"38670097",
"35378690",
"38279122",
"36186154",
"30030732",
"37002577",
"17959415",
"31462327",
"33060625",
"36793444",
"31295152",
"35952709",
"19720922",
"27400939",
"33096021",
"29395328",
"32499221",
"35236964",
"37575250",
"38562940",
"38556545",
"38816455",
"38311623",
"36831648",
"37978566",
"36614326",
"38243280",
"38715945",
"38454346",
"38175602",
"32958932",
"33268821",
"32759948",
"35359397",
"38802766",
"38255228",
"38580812",
"19801663",
"36581340",
"22635005",
"26849680",
"26280654",
"24101524",
"27157716",
"11001068",
"19482086",
"22064426",
"29371595",
"37169756",
"36901858",
"28706266",
"23669226",
"21941296",
"34050022",
"32470491",
"34987525",
"25014786",
"22437938",
"25196648",
"34685692",
"33562829",
"35281003",
"35842983",
"36990507",
"37951481",
"38213742",
"38872402",
"38255995",
"38672182",
"34179005",
"20501841",
"18829565",
"19860846",
"33262763",
"32335505",
"33139264",
"30799939",
"30584320",
"27993816",
"26220913",
"24368879",
"20048182",
"26048277",
"32547208",
"27239240",
"26446239",
"23940216",
"23076213",
"35303878",
"35158766",
"30404198",
"17189398",
"18242201",
"25053887",
"17332278",
"22836448",
"25031981",
"23598172",
"30806847",
"31076365",
"30850562",
"19074844",
"30742782",
"17222792",
"22127927",
"14745444",
"31824930",
"32034288",
"26578779",
"28404865",
"29217526",
"26189059",
"27507056",
"20490982",
"33262705",
"36853205",
"32183954",
"25665467",
"37093870",
"28892469",
"31968248",
"29508855",
"30779529",
"25901286",
"32707093",
"32646971",
"31024552",
"23967403",
"24167277",
"32579890",
"37703928",
"37460554",
"38791979",
"38619704",
"38640932",
"31825703",
"27812005",
"38092144",
"38171243",
"34149730",
"37727791",
"37907742",
"38193080",
"28534509",
"15758009",
"20414201",
"30742119",
"30936321",
"31099649",
"35121889",
"10487832",
"22212097",
"19957372",
"22104964",
"32118030",
"32351878",
"33037194",
"38332915",
"36831562",
"38693104",
"38227562",
"38201302",
"38690275",
"38558132",
"38544822",
"31063753",
"15753370",
"18438415",
"22967435",
"15933741",
"21822945",
"36588107",
"38410129",
"31478830",
"23299539",
"29232172",
"29235360",
"30817250",
"28246206",
"28246207",
"34439102",
"38637540",
"38239190",
"33804613",
"31145418",
"35608580",
"29298864",
"33731845",
"35598365",
"35216114",
"37754230",
"35356286",
"38685282",
"27241473",
"29106400",
"33283357",
"35163650",
"36228156",
"30785827",
"36636049",
"30860950",
"36224457",
"36672719",
"35798726",
"20479403",
"18974394",
"28332352",
"19168635",
"32411684",
"37787935",
"36951547",
"38745196",
"39038631",
"39085612",
"37555952",
"36253536",
"38322318",
"38183010",
"34239137",
"33542131",
"33303685",
"36523635",
"29796620",
"34294795",
"35127700",
"35334808",
"35625868",
"35429118",
"30214578",
"38560222",
"18537536",
"38013112",
"36103048",
"30842679",
"32661409",
"28923537",
"29097494",
"29302014",
"29097493",
"38631285",
"28753429",
"32798252",
"33006175",
"32742461",
"33668827",
"31434891",
"33398194",
"38292487",
"38791327",
"38755125",
"38415258",
"38642552",
"28605656",
"28734735",
"30413828",
"27550820",
"29097419",
"27641098",
"20026743",
"26771115",
"31208697",
"29222311",
"30233579",
"26876171",
"29987406",
"29481632",
"29851283",
"32328458",
"35478247",
"35020831",
"37091144",
"32677979",
"33277742",
"26724433",
"29686425",
"27913228",
"27924752",
"28636851",
"29657128",
"28515944",
"17008531",
"21245428",
"24122236",
"30301825",
"20220182",
"20823140",
"18372076",
"17583745",
"26782761",
"24013721",
"21853076",
"22785211",
"19671732",
"27742686",
"34852849",
"31889899",
"33173749",
"29059160",
"30241395",
"38322418",
"38672680",
"30608567",
"29632196",
"28490665",
"28915554",
"32415924",
"28825599",
"31444250",
"26253731",
"25601652",
"33138314",
"30320341",
"15087401",
"33939305",
"17051156",
"29552200",
"31722999",
"36865554",
"18776173",
"25417103",
"18245495",
"28258923",
"28518141",
"21683887",
"15063685",
"21904528",
"27811150",
"26807645",
"24012339",
"27335774",
"22001850",
"26880981",
"36115852",
"32151666",
"12189386",
"21430269",
"20682976",
"22763439",
"33682185",
"29550255",
"25446042",
"29967214",
"38239394",
"21315783",
"30319622",
"21110318",
"19244102",
"31001733",
"33750895",
"31130723",
"36749798",
"29802888",
"35046801",
"30755403",
"25684678",
"21725369",
"19336515",
"19544473",
"22039576",
"22156207",
"26269531",
"25972604",
"22516258",
"22863786",
"24323355",
"26883990",
"28346412",
"28776578",
"24691994",
"24777247",
"27111235",
"30190371",
"37006319",
"34220806",
"23922012",
"30696630",
"31261963",
"28835188",
"34663337",
"34776358",
"22888475",
"34094967",
"21300764",
"29170400",
"30766539",
"15322536",
"24430672",
"35037899",
"15144951",
"19098000",
"22967802",
"28105174",
"19887481",
"22561672",
"28364160",
"12628185",
"25109450",
"15380586",
"11306467",
"17376891",
"9834220",
"33258011",
"35585567",
"37692844",
"28187288",
"23344542",
"26639656",
"27119231",
"23993685",
"29300322",
"27666124",
"28122866",
"23091115",
"16361555",
"16230409",
"25193862",
"26554308",
"26282169",
"23792563",
"20501804",
"34388376",
"26789630",
"36122306",
"33402388",
"33744274",
"37077808",
"30547810",
"39075108",
"38335304",
"39115426",
"38695342",
"37909330",
"38181788",
"37352863",
"38847806",
"30781344",
"35541919",
"32399776",
"37164297",
"37350955",
"31756919",
"33732706",
"33722297",
"29219656",
"36035873",
"38203311",
"38019470",
"36819132",
"36090045",
"19549927",
"31730862",
"33291370",
"22874531",
"38810814",
"35130111",
"31741757",
"22595057",
"38787372",
"38989740",
"30370351",
"34715253",
"38464167",
"39227970",
"30241505",
"37284236",
"30713991",
"35725926",
"37055220",
"29212283",
"38241600",
"34137945",
"35674738",
"33357190",
"24900696",
"31924719",
"32728208",
"32060219",
"38355986",
"36803004",
"37875466",
"33976268",
"34663898"
] | [] | 10.562271 | 5.159496 |
39806405 | 34 | Engineered T cells secreting αB7-H3-αCD3 bispecific engagers for enhanced anti-tumor activity against B7-H3 positive multiple myeloma: a novel therapeutic approach. | Multiple myeloma (MM) is an incurable plasma cell malignancy with increasing global incidence. Chimeric antigen receptor (CAR) T-cell therapy targeting BCMA has shown efficacy in relapsed or refractory MM, but it faces resistance due to antigen loss and the tumor microenvironment. Bispecific T-cell engaging (BITE) antibodies also encounter clinical challenges, including short half-lives requiring continuous infusion and potential toxicities.
To address these issues, we developed a lentiviral system to engineer T cells that secrete αB7-H3-αCD3 bispecific engager molecules (αB7-H3-αCD3 ENG-T cells). We evaluated their effectiveness against MM cells with varying B7-H3 expression levels, from B7-H3
The αB7-H3-αCD3 ENG-T cells demonstrated significant anti-tumor activity against MM cell lines expressing B7-H3. SupT-1 cells (B7-H3
These results indicate that αB7-H3-αCD3 ENG T cells could be a promising therapy for B7-H3-positive MM. They may enhance current MM treatments and improve overall outcomes. Additional preclinical and clinical research is required to fully assess their therapeutic potential. | [
0.017284415662288666,
0.005753311328589916,
0.045292023569345474,
0.02209516428411007,
-0.06375158578157425,
-0.005226944573223591,
0.01157394889742136,
0.02857069857418537,
-0.005052508786320686,
-0.02263377234339714,
-0.0018514645053073764,
-0.038143228739500046,
-0.04355379194021225,
0.02149534970521927,
0.03447090461850166,
-0.0010764506878331304,
0.041154537349939346,
-0.006548982113599777,
-0.0021039368584752083,
0.0262204110622406,
0.017345622181892395,
0.03243888169527054,
0.01648874580860138,
0.019610222429037094,
-0.011549466289579868,
-0.000707687868271023,
-0.01211867667734623,
0.00013675590162165463,
-0.007252844516187906,
-0.035670530050992966,
0.027444519102573395,
-0.029966183006763458,
-0.017125282436609268,
-0.0037488332018256187,
-0.024372005835175514,
0.015178948640823364,
0.027420036494731903,
0.026661088690161705,
-0.004746481776237488,
0.010202947072684765,
0.041130054742097855,
0.023735469207167625,
0.022119645029306412,
0.08274975419044495,
-0.037335317581892014,
-0.0064938971772789955,
-0.014309831894934177,
-0.028913449496030807,
0.029794808477163315,
0.00662242854014039,
0.012877624481916428,
0.013979322277009487,
-0.03197371959686279,
0.0771678164601326,
-0.006744839251041412,
0.01669684424996376,
-0.028325878083705902,
0.049747779965400696,
0.01408949214965105,
-0.011806529015302658,
-0.001486527151428163,
-0.029966183006763458,
0.0033571182284504175,
-0.019157301634550095,
-0.035646047443151474,
-0.015619628131389618,
-0.03718842566013336,
-0.01388139370828867,
0.009976486675441265,
0.00013627774023916572,
-0.009168574586510658,
-0.054301466792821884,
0.00048161030281335115,
0.014052769169211388,
0.027420036494731903,
-0.0037304714787751436,
-0.022719459608197212,
0.014799474738538265,
-0.038657356053590775,
-0.004819928202778101,
0.008838064968585968,
0.023233585059642792,
0.017431309446692467,
-0.022988762706518173,
-0.006873370613902807,
0.00772412633523345,
0.02073640190064907,
-0.009823473170399666,
-0.052636679261922836,
-0.008005671203136444,
-0.022266538813710213,
-0.018422836437821388,
-0.05768000707030296,
0.043211039155721664,
0.004985183011740446,
0.016145994886755943,
-0.028325878083705902,
-0.07829400151968002,
0.022352226078510284,
0.0494295135140419,
0.011108786799013615,
0.011518863961100578,
-0.01401604525744915,
-0.003926328849047422,
0.04064041003584862,
-0.047519903630018234,
-0.011427055113017559,
0.011078184470534325,
0.03248784691095352,
0.0009525096393190324,
0.06311504542827606,
-0.008838064968585968,
-0.0037365921307355165,
0.032904043793678284,
0.005508489441126585,
-0.03378540277481079,
-0.013783465139567852,
-0.01427310798317194,
0.012461427599191666,
-0.0020029479637742043,
-0.01618271879851818,
0.04592856019735336,
0.02411494217813015,
-0.07305481284856796,
0.000032802290661493316,
-0.018018880859017372,
0.08015464246273041,
-0.01968366838991642,
-0.026783499866724014,
-0.05337114259600639,
0.03875528275966644,
-0.022144127637147903,
0.029501020908355713,
-0.014530171640217304,
-0.06507362425327301,
0.01027639303356409,
-0.03716394305229187,
-0.01150050200521946,
-0.04879297688603401,
0.01408949214965105,
0.013269338756799698,
-0.011739203706383705,
0.0017061015823855996,
0.003868183819577098,
-0.031900275498628616,
-0.08088910579681396,
-0.030455825850367546,
0.01317141018807888,
0.024702515453100204,
0.02248687855899334,
-0.02387012168765068,
0.008440230041742325,
0.03574397787451744,
0.023772193118929863,
-0.014664823189377785,
-0.02896241471171379,
-0.03182682767510414,
0.06566119194030762,
-0.012987794354557991,
-0.06766873598098755,
-0.011341367848217487,
0.007338532246649265,
-0.04392102360725403,
-0.019585739821195602,
0.018545247614383698,
0.041399359703063965,
-0.025143194943666458,
0.03973457217216492,
-0.046589579433202744,
-0.00910124834626913,
0.0019555138424038887,
-0.010943532921373844,
-0.07359342277050018,
-0.018998168408870697,
-0.05616211146116257,
-0.007546630688011646,
0.021421903744339943,
-0.04147280380129814,
-0.047544386237859726,
-0.007975068874657154,
-0.011261801235377789,
0.037751514464616776,
0.04409239813685417,
0.013257098384201527,
-0.028913449496030807,
0.013575366698205471,
-0.032145097851753235,
0.0440189503133297,
-0.01925523206591606,
-0.025033025071024895,
0.02749348245561123,
0.024861648678779602,
0.055476609617471695,
-0.012020748108625412,
-0.005643141455948353,
-0.003984474111348391,
0.04201141372323036,
0.03287956118583679,
-0.015227912925183773,
-0.0014077251544222236,
0.029501020908355713,
-0.03532778099179268,
-0.01745579205453396,
-0.004382309503853321,
-0.035792939364910126,
-0.026954876258969307,
0.003152080113068223,
0.028791038319468498,
-0.01974487490952015,
0.024886131286621094,
0.04955192282795906,
0.014701546169817448,
0.0313371866941452,
0.01329382136464119,
-0.035376742482185364,
-0.013991563580930233,
-0.04502272233366966,
0.019010409712791443,
0.012951071374118328,
0.04619786515831947,
-0.004685276187956333,
-0.00978062953799963,
-0.013563125394284725,
0.044533077627420425,
-0.05645589530467987,
-0.011267920956015587,
0.014566894620656967,
-0.013869152404367924,
0.004547564312815666,
-0.010631384328007698,
-0.014065009541809559,
-0.009413396939635277,
0.03182682767510414,
-0.03138614818453789,
-0.07437685132026672,
-0.0209445022046566,
0.012987794354557991,
0.012137038633227348,
0.06130336970090866,
-0.015215672552585602,
0.030602719634771347,
0.03246336430311203,
0.03549915552139282,
-0.02609799988567829,
-0.007736367639154196,
-0.006836647633463144,
-0.0003750745963770896,
-0.07256516814231873,
0.023882362991571426,
0.0037794357631355524,
-0.011182233691215515,
0.019059373065829277,
-0.008097480051219463,
-0.0007532094605267048,
0.028399324044585228,
0.025902142748236656,
-0.012363499030470848,
0.03302645683288574,
0.020871054381132126,
-0.05929582938551903,
-0.019610222429037094,
0.04144832491874695,
-0.05111878365278244,
-0.017174245789647102,
-0.04193796589970589,
0.007785331923514605,
-0.009774508886039257,
0.01667236164212227,
0.0768740326166153,
-0.017896469682455063,
-0.009015561081469059,
0.014530171640217304,
0.02959894947707653,
-0.0037243510596454144,
-0.03185131028294563,
-0.008134203031659126,
0.004755662754178047,
0.019573500379920006,
0.014175179414451122,
0.01460361760109663,
-0.004158909432590008,
0.012816418893635273,
-0.000014524337530019693,
-0.021923787891864777,
-0.03897562250494957,
-0.022046199068427086,
0.03821667656302452,
-0.039318375289440155,
-0.029133789241313934,
0.007546630688011646,
0.018153533339500427,
-0.01113939005881548,
-0.006065458990633488,
-0.02712625078856945,
-0.035572599619627,
-0.0007382906042039394,
0.005842059385031462,
-0.05934479460120201,
-0.01270624902099371,
0.05337114259600639,
0.014260867610573769,
0.012865383177995682,
-0.03946526721119881,
-0.048964351415634155,
0.04277035966515541,
0.04110557213425636,
-0.039440784603357315,
-0.024849409237504005,
0.02661212533712387,
0.03990594670176506,
0.02368650585412979,
-0.028742074966430664,
0.021385179832577705,
0.025241123512387276,
0.006689754314720631,
-0.04186452180147171,
-0.01675804890692234,
-0.01983056217432022,
-0.0042078737169504166,
-0.05229392647743225,
-0.009958124719560146,
-0.003347937483340502,
-0.04602649062871933,
-0.020834332332015038,
0.010857844725251198,
-0.008648328483104706,
0.027811750769615173,
-0.0030801636166870594,
0.011898336932063103,
-0.027346590533852577,
0.04512064903974533,
-0.014591376297175884,
0.04798506572842598,
-0.049747779965400696,
-0.013281580060720444,
-0.015423770993947983,
-0.03816771134734154,
-0.005774733144789934,
-0.0035101319663226604,
0.025033025071024895,
-0.030186522752046585,
0.021936029195785522,
-0.024433210492134094,
0.04144832491874695,
0.01232677511870861,
-0.01708855852484703,
-0.006178689189255238,
0.011286282911896706,
0.013024517334997654,
0.030749613419175148,
0.004966821521520615,
0.00417421106249094,
0.04196244850754738,
-0.0046148900873959064,
-0.014811716042459011,
-0.012669526040554047,
-0.026930393651127815,
-0.004718939308077097,
0.03393229469656944,
-0.005881842691451311,
0.0040915836580097675,
0.012436944991350174,
-0.031900275498628616,
0.010704831220209599,
0.08475729078054428,
0.06003029644489288,
-0.00019987401901744306,
0.012951071374118328,
-0.045292023569345474,
-0.01865541748702526,
-0.014260867610573769,
0.035548120737075806,
0.007228362374007702,
0.01983056217432022,
-0.020332446321845055,
0.005539092235267162,
0.004235416185110807,
0.012816418893635273,
-0.015754280611872673,
0.026391785591840744,
0.045708220452070236,
-0.002960813231766224,
0.0051106540486216545,
-0.047128189355134964,
-0.02061399258673191,
0.009805111214518547,
0.01832490786910057,
-0.009609254077076912,
-0.07148795574903488,
0.023527370765805244,
0.03765358775854111,
0.011873855255544186,
0.005848179571330547,
-0.009847954846918583,
-0.026636607944965363,
0.045047204941511154,
-0.018643176183104515,
0.07550302892923355,
0.04024869576096535,
0.03114132769405842,
0.014481207355856895,
-0.03275715187191963,
-0.008036274462938309,
-0.04889090359210968,
-0.003754953620955348,
-0.02061399258673191,
0.0198917668312788,
0.013465196825563908,
0.03380988538265228,
-0.009798990562558174,
-0.022388949990272522,
-0.011004737578332424,
0.031753383576869965,
0.04338241368532181,
-0.002786377677693963,
0.0005313397268764675,
-0.03936733677983284,
0.05934479460120201,
0.02417614869773388,
0.00988467875868082,
-0.04169314354658127,
-0.05723932757973671,
0.03545019030570984,
0.004743421450257301,
-0.01735786348581314,
-0.07653128355741501,
0.04237864539027214,
-0.0025293147191405296,
-0.003000596771016717,
-0.0260735172778368,
-0.04071385785937309,
0.07207552343606949,
0.0251676756888628,
-0.012283931486308575,
0.003399962093681097,
0.022413432598114014,
-0.04303966462612152,
-0.007063107565045357,
-0.04984571039676666,
0.05929582938551903,
-0.03172890096902847,
-0.0018927782075479627,
-0.014334313571453094,
-0.02986825443804264,
0.013942599296569824,
0.014983091503381729,
-0.010539576411247253,
0.01904713176190853,
-0.017321139574050903,
-0.008954355493187904,
0.00586348120123148,
-0.05797379091382027,
0.023698745295405388,
0.041007645428180695,
-0.02543698064982891,
-0.0071120718494057655,
0.06526947766542435,
-0.03682119399309158,
0.006873370613902807,
0.006395968608558178,
0.04286829009652138,
-0.0602751150727272,
-0.01083336304873228,
-0.011053701862692833,
-0.01735786348581314,
0.0104722511023283,
0.016770290210843086,
-0.022046199068427086,
0.01395484060049057,
-0.03388332948088646,
0.04184003919363022,
0.03508295863866806,
-0.018459560349583626,
0.02435976453125477,
-0.03366298973560333,
0.04898883402347565,
-0.006420450750738382,
0.012369619682431221,
0.036037761718034744,
0.0017458851216360927,
0.00937667302787304,
-0.05258771404623985,
-0.028105538338422775,
-0.018496284261345863,
0.0029699939768761396,
0.05102085322141647,
-0.027615893632173538,
0.00015951668319758028,
-0.013734500855207443,
0.04093419760465622,
0.0033632388804107904,
-0.02380891516804695,
-0.004957640543580055,
-0.012259449809789658,
0.017688371241092682,
-0.015436011366546154,
0.007932225242257118,
-0.05043328180909157,
-0.011947302147746086,
0.008421868085861206,
-0.02384563907980919,
0.023074449971318245,
-0.010190705768764019,
0.026636607944965363,
0.026367302983999252,
0.0066163078881800175,
-0.008599364198744297,
0.029819289222359657,
-0.042207270860672,
0.04578166827559471,
-0.02529008686542511,
-0.019695909693837166,
-0.0021238287445157766,
0.003366299206390977,
-0.022927558049559593,
-0.03848598152399063,
-0.03354058042168617,
0.000369527842849493,
0.0011430116137489676,
0.017223211005330086,
0.003360178554430604,
-0.011794287711381912,
0.006298039574176073,
0.016109270974993706,
0.03180234506726265,
-0.04854815453290939,
-0.04154625162482262,
-0.03860839083790779,
-0.04232968017458916,
-0.048034027218818665,
0.002994476119056344,
0.00567374425008893,
0.009492963552474976,
0.03050479106605053,
-0.025069747120141983,
-0.019463330507278442,
-0.03851046413183212,
0.03471572697162628,
-0.037604622542858124,
-0.031508561223745346,
0.023564094677567482,
0.0023655903059989214,
0.03900010511279106,
0.018581971526145935,
0.010943532921373844,
-0.00045980585855431855,
0.0177862998098135,
0.00872789602726698,
0.017186487093567848,
0.0154482526704669,
0.04472893476486206,
-0.030602719634771347,
0.03001514822244644,
-0.01937764137983322,
0.018912481144070625,
-0.025118712335824966,
-0.021960511803627014,
-0.028399324044585228,
0.010772157460451126,
0.013355026952922344,
-0.0038987863808870316,
-0.021862583234906197,
0.015742039307951927,
-0.028130019083619118,
-0.015962379053235054,
0.012694007717072964,
-0.013807946816086769,
0.0022018656600266695,
-0.029966183006763458,
0.04264795035123825,
0.000871412456035614,
0.00020503821724560112,
0.002282962901517749,
-0.014334313571453094,
0.014566894620656967,
-0.008489194326102734,
-0.017382344231009483,
0.006720357108861208,
0.0003285967104602605,
-0.004985183011740446,
-0.0198917668312788,
-0.008293337188661098,
-0.015864450484514236,
0.045977525413036346,
-0.001293729990720749,
0.0077057648450136185,
-0.05151049792766571,
-0.0029791747219860554,
-0.02106691151857376,
0.02267049439251423,
0.01667236164212227,
-0.012853141874074936,
-0.0032622499857097864,
-0.01206971239298582,
-0.018936963751912117,
0.021262768656015396,
-0.010851724073290825,
-0.012216605246067047,
-0.057435184717178345,
-0.010178464464843273,
0.017308898270130157,
0.0014696955913677812,
-0.013905875384807587,
-0.014738270081579685,
-0.011537224985659122,
0.06218472495675087,
0.0023808914702385664,
-0.016598915681242943,
-0.006665272172540426,
0.033687472343444824,
0.03456883132457733,
0.06429019570350647,
-0.016745807603001595,
0.0015362565172836185,
0.012124797329306602,
0.02007538452744484,
-0.017896469682455063,
0.007026384584605694,
-0.0009754616767168045,
0.003794737160205841,
0.006769321393221617,
-0.003715170081704855,
-0.0006418920238502324,
0.025975588709115982,
0.013085722923278809,
-0.0654163733124733,
-0.03493606299161911,
0.011512743309140205,
0.037996336817741394,
0.006463294383138418,
-0.03231647238135338,
-0.031067881733179092,
-0.018581971526145935,
0.012853141874074936,
0.0028047391679137945,
-0.014542412012815475,
0.021593278273940086,
-0.018288185819983482,
0.004777084570378065,
-0.017015112563967705,
-0.025118712335824966,
0.00789550133049488,
-0.005138196516782045,
-0.00955416914075613,
0.008489194326102734,
-0.017406826838850975,
-0.017982158809900284,
-0.0037090496625751257,
-0.004330284893512726,
-0.03167993575334549,
-0.005866541527211666,
-0.015742039307951927,
0.027077285572886467,
-0.017406826838850975,
0.025583874434232712,
-0.03454434871673584,
-0.021556556224822998,
0.005939987953752279,
0.0702148824930191,
0.04876849427819252,
-0.03341817110776901,
0.029305163770914078,
-0.003862063167616725,
-0.03755565732717514,
0.0131102055311203,
-0.025143194943666458,
-0.015142225660383701,
-0.0027986187487840652,
0.007485425099730492,
-0.0012172231217846274,
0.07902846485376358,
-0.010153982788324356,
0.02333151362836361,
-0.0014842319069430232,
0.024335281923413277,
0.01203911006450653,
0.010980255901813507,
-0.021617760881781578,
-0.0179331935942173,
0.007516027893871069,
0.01850852556526661,
-0.0028720651753246784,
-0.04017525166273117,
-0.07834295928478241,
0.008434109389781952,
0.030284451320767403,
0.004513901192694902,
-0.008158684708178043,
-0.00706922821700573,
-0.017259933054447174,
0.018618695437908173,
-0.014517930336296558,
-0.015301359817385674,
-0.014983091503381729,
0.012608320452272892,
-0.025057507678866386,
0.0011323005892336369,
-0.005006604827940464,
-0.020026419311761856,
-0.049625370651483536,
0.016978388652205467,
0.006105242762714624,
0.047152671962976456,
-0.020454857498407364,
0.03464227914810181,
-0.014995332807302475,
-0.02842380665242672,
0.009186936542391777,
0.016133753582835197,
0.03454434871673584,
-0.026269374415278435,
-0.004440454766154289,
-0.01935316063463688,
-0.043211039155721664,
0.0001345563359791413,
-0.00013981616939418018,
-0.015178948640823364,
0.0458061508834362,
-0.008495314978063107,
0.004247657489031553,
0.013991563580930233,
0.020895536988973618,
-0.04379861056804657,
0.009572531096637249,
0.03679671138525009,
-0.0022033958230167627,
-0.05219599977135658,
0.05106981843709946,
-0.004220115020871162,
-0.027028322219848633,
-0.009633735753595829,
-0.0003020105941686779,
-0.011133269406855106,
-0.021605519577860832,
0.009144092909991741,
0.06051993742585182,
0.0011292403796687722,
-0.022952038794755936,
-0.03158200532197952,
-0.022523602470755577,
0.040885232388973236,
-0.018949203193187714,
-0.038388051092624664,
0.016660120338201523,
-0.013342785649001598,
0.046614062041044235,
0.04355379194021225,
0.009805111214518547,
0.0016142934327945113,
-0.014101733453571796,
-0.017125282436609268,
0.00908900797367096,
-0.023698745295405388,
-0.011622913181781769,
-0.013097964227199554,
-0.005946108605712652,
0.012241087853908539,
0.009541927836835384,
-0.020724162459373474,
-0.018018880859017372,
-0.04247657582163811,
0.0033571182284504175,
-0.0370660126209259,
0.010270272381603718,
-0.03988146409392357,
-0.006726477760821581,
0.005716587882488966,
0.024090461432933807,
0.015901172533631325,
0.023233585059642792,
-0.018581971526145935,
-0.011910578235983849,
0.026514196768403053,
0.00012547115329653025,
0.024543380364775658,
0.01317141018807888,
-0.037751514464616776,
-0.025926623493433,
0.0029852953739464283,
0.01434655487537384,
0.009113489650189877,
0.0010481431381776929,
-0.0037916770670562983,
-0.005584996193647385,
0.025216640904545784,
0.04744645580649376,
0.01760268397629261,
0.01908385567367077,
-0.03270818665623665,
-0.02776278741657734,
-0.031214773654937744,
0.016207199543714523,
-0.01992849074304104,
0.018435077741742134,
-0.014738270081579685,
0.007252844516187906,
0.0439944714307785,
-0.08940890431404114,
-0.023613058030605316,
-0.007644559256732464,
-0.013146928511559963,
-0.015436011366546154,
-0.008629966527223587,
-0.010557938367128372,
0.0020151890348643064,
-0.015081020072102547,
-0.022352226078510284,
0.008268854580819607,
0.0003157817991450429,
0.0034825894981622696,
-0.0021284192334860563,
0.004158909432590008,
-0.04683440178632736,
-0.003433625213801861,
-0.03258577734231949,
0.007460942957550287,
0.012124797329306602,
0.028227947652339935,
0.027836233377456665,
-0.0022860232274979353,
0.023196861147880554,
-0.012020748108625412,
0.01157394889742136,
-0.020565027371048927,
0.019634705036878586,
-0.03334472328424454,
-0.03985698148608208,
0.003693748265504837,
0.035009510815143585,
-0.013195892795920372,
0.04406791552901268,
-0.0229030754417181,
-0.023380476981401443,
0.01847180165350437,
0.005064750090241432,
0.010362081229686737,
-0.00009993700950872153,
-0.004731180611997843,
0.011512743309140205,
0.03491158410906792,
0.01606030762195587,
-0.018949203193187714,
0.0032836718019098043,
-0.010282513685524464,
-0.00008191008964786306,
0.003011307679116726,
-0.024396488443017006,
0.0021574916318058968,
-0.023037727922201157,
-0.023502888157963753,
0.02300100401043892,
0.014909644611179829,
-0.0524408221244812,
-0.012596079148352146,
0.028791038319468498,
0.025388015434145927,
0.033687472343444824,
-0.00267161731608212,
0.010564059019088745,
0.025265606120228767,
-0.018826793879270554,
-0.0020213096868246794,
0.005811456590890884,
-0.012620561756193638,
0.05102085322141647,
-0.03231647238135338,
0.012571597471833229,
-0.011769806034862995,
0.016562191769480705,
-0.015803243964910507,
0.02999066561460495,
0.02634282037615776,
-0.008232131600379944,
-0.024372005835175514,
0.008978838101029396,
-0.014738270081579685,
0.014615858905017376,
0.011843252927064896,
-0.025657320395112038,
-0.01690494269132614,
0.02284187078475952,
-0.002751184394583106,
-0.007809814065694809,
-0.0044863587245345116,
0.006463294383138418,
0.01964694634079933,
0.0034030224196612835,
0.002206456148996949,
-0.01355088409036398,
-0.028350358828902245,
0.003445866284891963,
0.013661053963005543,
-0.045855116099119186,
-0.04174210876226425,
-0.0014934127684682608,
-0.0034213841427117586,
-0.007822055369615555,
0.05958961695432663,
-0.024408729746937752,
0.011598430573940277,
-0.04815644025802612,
0.008507556281983852,
-0.010527335107326508,
0.031190291047096252,
-0.021923787891864777,
0.000009282426617573947,
-0.014383277855813503,
0.01673356629908085,
-0.01206971239298582,
0.02176465466618538,
-0.002261541085317731,
0.026024552062153816,
0.021936029195785522,
0.038681838661432266,
-0.01859421283006668,
0.014187420718371868,
-0.00934607069939375,
0.05596625432372093,
0.043749649077653885,
-0.00929710641503334,
-0.03902458772063255,
-0.0007141909445635974,
0.0071181925013661385,
0.01875334605574608,
0.030186522752046585,
-0.0018009700579568744,
-0.009701061993837357,
0.021776895970106125,
0.0644860491156578,
-0.008268854580819607,
-0.030676165595650673,
-0.027713822200894356,
0.030333416536450386,
-0.0035040113143622875,
0.02568180300295353,
0.028521735221147537,
0.0253145694732666,
0.003742712549865246,
-0.03246336430311203,
-0.010319236665964127,
-0.00713655399158597,
0.02661212533712387,
-0.004171150736510754,
-0.04534098878502846,
0.01760268397629261,
-0.005643141455948353,
-0.004134427290409803,
-0.0016770290676504374,
0.02815450169146061,
0.011255680583417416,
0.06223369017243385,
0.001387833384796977,
0.01964694634079933,
-0.0045934682711958885,
-0.024555621668696404,
-0.013073481619358063,
0.025755248963832855,
-0.0319492407143116,
0.0638984814286232,
-0.017945434898138046,
-0.03207165002822876,
0.0032653100788593292,
-0.013991563580930233,
-0.005208583083003759,
0.02215636894106865,
0.003822279628366232,
0.03471572697162628,
-0.002699159784242511,
-0.07006798684597015,
0.05562350153923035,
-0.0041130054742097855,
-0.03417711704969406,
-0.007001902442425489,
0.02986825443804264,
-0.0033754799515008926,
0.01892472244799137,
0.023735469207167625,
0.007332411594688892,
-0.017688371241092682,
-0.005153498146682978,
0.014052769169211388,
0.002775666769593954,
-0.023502888157963753,
-0.01667236164212227,
0.00026337464805692434,
0.027983127161860466,
0.003378540277481079,
-0.019340919330716133,
-0.011384211480617523,
0.03478917106986046,
0.05097188800573349,
0.06115647405385971,
-0.013379508629441261,
0.0014054299099370837,
0.04918469116091728,
-0.03128822147846222,
-0.04002835601568222,
-0.025632837787270546,
0.01624392345547676,
0.03182682767510414,
-0.01472602877765894,
-0.019463330507278442,
0.012443065643310547,
0.044655486941337585,
-0.057043470442295074,
-0.021740172058343887,
0.07129209488630295,
0.003950810991227627,
0.040762823075056076,
-0.02766485884785652,
0.007913863286376,
0.026563160121440887,
-0.00526672787964344,
-0.011733083054423332,
0.0010190705070272088,
-0.019585739821195602,
0.0021345396526157856,
-0.015252395533025265,
-0.0358663871884346,
-0.011194474995136261,
0.014358796179294586,
0.009107368998229504,
-0.00006445698090828955,
0.010441647842526436,
0.0029501020908355713,
-0.0017458851216360927,
0.022915316745638847,
-0.015423770993947983,
0.04122798517346382,
0.020332446321845055,
0.003418323816731572,
-0.007271206006407738,
0.009015561081469059,
0.0006395968375727534,
-0.03336920589208603,
0.009425637312233448,
-0.03699256852269173,
0.03366298973560333,
0.04693233221769333,
-0.019120579585433006,
-0.021813618019223213,
-0.002116178162395954,
-0.001415375736542046,
0.056406933814287186,
-0.01157394889742136,
-0.007008022628724575,
-0.024151666089892387,
-0.005900204181671143,
0.003372419625520706,
-0.0056982263922691345,
0.02188706584274769,
0.007662921212613583,
0.01871662400662899,
0.0006526029901579022,
0.006861129775643349,
0.0434068962931633,
-0.00984183419495821,
0.014493447728455067,
-0.023625299334526062,
-0.026318339630961418,
0.021152600646018982,
0.00655510276556015,
0.00425071781501174,
-0.00893599446862936,
-0.007669041398912668,
0.01923074945807457,
0.04409239813685417,
-0.009419516660273075,
0.004501659888774157,
-0.020479340106248856,
0.004660794045776129,
0.009652097709476948,
-0.02906034328043461,
0.050384316593408585,
-0.018153533339500427,
0.006959058344364166,
-0.006432691588997841,
-0.02673453651368618,
0.004933158401399851,
0.00006201832729857415,
0.016207199543714523,
0.024188390001654625,
0.007148795295506716,
-0.03483813628554344,
-0.013257098384201527,
0.031239256262779236,
-0.03339368849992752,
-0.008991079404950142,
0.013783465139567852,
-0.0007183988345786929,
-0.013856911100447178,
-0.007589474320411682,
-0.03153304383158684,
-0.007626197766512632,
-0.028105538338422775,
-0.02438424713909626,
-0.025632837787270546,
-0.018214737996459007,
0.027077285572886467,
0.003418323816731572,
-0.019720392301678658,
0.020626233890652657,
0.0015232503646984696,
-0.012149279937148094,
-0.03704153001308441,
0.03589086979627609,
-0.009829593822360039,
-0.040860749781131744,
0.005395259242504835,
0.012063591741025448,
-0.019463330507278442,
-0.008495314978063107,
0.008299457840621471,
-0.0008216830319724977,
0.008213769644498825,
0.0019708152394741774,
-0.0022630710154771805,
0.007271206006407738,
-0.010147862136363983,
-0.012259449809789658,
0.026122480630874634,
-0.016415297985076904,
0.004936218727380037,
0.023368237540125847,
-0.01902265101671219,
-0.02145862765610218,
-0.01908385567367077,
0.028619663789868355,
0.0020825150422751904,
0.005226944573223591,
0.007161036599427462,
-0.008391265757381916,
-0.0008515206864103675,
-0.00817092601209879,
-0.013844670727849007,
0.02224205620586872,
-0.0031826829072088003,
-0.011537224985659122,
-0.011843252927064896,
0.02139742113649845,
0.013905875384807587,
0.00111699930857867,
0.0002400400844635442,
0.000002785325705190189,
-0.0007658330723643303,
0.0021284192334860563,
-0.030994433909654617,
0.060422010719776154,
-0.036331549286842346,
-0.024457693099975586,
0.03780047968029976,
0.016170477494597435,
-0.0034825894981622696,
0.00314595946110785,
0.016770290210843086,
0.007001902442425489,
-0.011004737578332424,
-0.0033571182284504175,
0.02380891516804695,
0.040615931153297424,
-0.0012791936751455069,
0.009970366023480892,
0.02137293852865696,
-0.010766036808490753,
-0.012020748108625412,
0.015962379053235054,
-0.011592309921979904,
0.012106436304748058,
0.016194960102438927,
-0.03101891651749611,
0.01883903332054615,
-0.027983127161860466,
0.022597048431634903,
0.03993042930960655,
0.029501020908355713,
0.00824437290430069,
0.02541249804198742,
-0.0179331935942173,
0.015154466964304447,
0.0074058580212295055,
-0.020699679851531982,
-0.010594661347568035,
-0.02541249804198742,
-0.046099938452243805,
-0.03297749161720276,
0.003950810991227627,
0.008568761870265007,
-0.0070325047709047794,
-0.002869004849344492,
0.0064082094468176365,
0.01648874580860138,
-0.004572046454995871,
-0.017774060368537903,
-0.007148795295506716,
0.010698710568249226,
-0.023074449971318245,
0.018361631780862808,
-0.01669684424996376,
0.01814129203557968,
0.020601751282811165,
0.01519118994474411,
0.012155400589108467,
0.013685536570847034,
0.013820188120007515,
0.014848439954221249,
0.006249075289815664,
-0.00788326095789671,
0.0156685933470726,
-0.006659151986241341,
-0.05381182208657265,
0.018973685801029205,
-0.00037411824450828135,
0.019695909693837166,
0.004844410344958305,
-0.006506138015538454,
-0.023233585059642792,
-0.009278744459152222,
0.006059338338673115,
-0.0013748272322118282,
0.020185554400086403,
-0.0006839708075858653,
-0.016133753582835197,
-0.006273557431995869,
0.020173313096165657,
-0.015864450484514236,
-0.0005841294187121093,
0.02495957724750042,
0.007564992178231478,
0.006934576202183962,
-0.0032285868655890226,
-0.00020274301641620696,
-0.059148937463760376,
0.008666690438985825,
-0.01968366838991642,
0.0023426380939781666,
-0.023466166108846664,
0.0017489454476162791,
-0.010564059019088745,
0.03471572697162628,
0.040371108800172806,
0.0340547077357769,
0.014162939041852951,
-0.016317369416356087,
-0.0066101872362196445,
-0.011953421868383884,
0.032561294734478,
-0.022254297509789467,
0.01557066384702921,
0.0008981898427009583,
-0.02269497700035572,
-0.01766389049589634,
-0.0367722287774086,
-0.0009479192667640746,
-0.030431345105171204,
-0.026954876258969307,
0.020381411537528038,
0.028007609769701958,
-0.020503822714090347,
-0.0020993466023355722,
0.009505204856395721,
0.014615858905017376,
0.007393617182970047,
0.007393617182970047,
-0.018814552575349808,
0.006653031334280968,
-0.009609254077076912,
0.011824890971183777,
0.02287859283387661,
0.027028322219848633,
-0.0059063248336315155,
0.017100799828767776,
0.025069747120141983,
-0.031092362478375435,
0.00355297583155334,
0.031875792890787125,
0.0067876833491027355,
-0.0026823284570127726,
-0.033050935715436935,
0.036576371639966965,
0.01342847291380167,
-0.020332446321845055,
0.005459525156766176,
0.02465355023741722,
-0.010147862136363983,
-0.03493606299161911,
0.01826370321214199,
0.019965214654803276,
-0.027934161946177483,
0.00041696205153129995,
-0.031092362478375435,
-0.021103635430336,
-0.00721000088378787,
-0.008085238747298717,
-0.01766389049589634,
0.0032683704048395157,
-0.016292888671159744,
0.020001936703920364,
-0.031753383576869965,
-0.020932260900735855,
-0.007785331923514605,
-0.015362565405666828,
0.010961893945932388,
0.0007004197686910629,
-0.03782496228814125,
-0.03743324801325798,
0.004945399705320597,
0.026391785591840744,
-0.03234095498919487,
-0.0007535919430665672,
-0.03116581030189991,
0.022254297509789467,
0.028081055730581284,
-0.027346590533852577,
-0.012596079148352146,
0.06517155468463898,
0.013306062668561935,
-0.02749348245561123,
0.016268406063318253,
0.007252844516187906,
0.010974135249853134,
-0.022927558049559593,
-0.04355379194021225,
-0.012167640961706638,
0.013257098384201527,
0.025975588709115982,
-0.02417614869773388,
-0.0038161592092365026,
0.04286829009652138,
-0.0071181925013661385,
0.005000484175980091,
-0.029109306633472443,
0.009499084204435349,
-0.023637540638446808,
0.0032959128729999065,
-0.004553684499114752,
-0.003647844074293971,
-0.03336920589208603,
-0.007736367639154196,
0.009664339013397694,
-0.005058629438281059,
-0.01654995046555996,
0.029427574947476387,
0.001390128512866795,
0.03745773062109947,
-0.016562191769480705,
0.00815256405621767,
0.05278357118368149,
0.021630002185702324,
-0.03322231397032738,
-0.015595145523548126,
0.03753117471933365,
-0.011543345637619495,
-0.02393132634460926,
-0.010606902651488781,
0.0177862998098135,
-0.03011307679116726,
0.013159169815480709,
0.02788519859313965,
0.005508489441126585,
-0.016831494867801666,
0.014921885915100574,
-0.017700612545013428,
-0.006395968608558178,
-0.009805111214518547,
0.008507556281983852,
-0.02333151362836361,
-0.010209067724645138,
-0.03620913624763489,
0.013183651491999626,
0.014444483444094658,
-0.01890023984014988,
-0.02999066561460495,
0.022352226078510284,
-0.010209067724645138,
-0.013563125394284725,
0.011580069549381733,
0.0066163078881800175,
-0.02333151362836361,
0.02221757359802723,
-0.03804530203342438,
0.018851274624466896,
-0.003225526539608836,
-0.03782496228814125,
-0.00453532300889492,
0.0008859487134031951,
0.017431309446692467,
0.01675804890692234,
-0.026832465082406998,
-0.00919305719435215,
0.023674264550209045,
0.0033448771573603153,
0.0260735172778368,
0.02749348245561123,
0.00750378705561161,
0.0037243510596454144,
-0.029035860672593117,
-0.0002534287632443011,
-0.010062173940241337,
0.026440748944878578,
0.00788326095789671,
-0.003868183819577098,
0.022388949990272522,
0.000888243957888335,
0.005150437820702791,
-0.01923074945807457,
-0.018373873084783554,
0.010392683558166027,
-0.03743324801325798,
0.00358663871884346,
-0.025069747120141983,
-0.01805560477077961,
-0.005958349443972111,
0.04225623607635498,
-0.031484078615903854,
0.009958124719560146,
0.008079118095338345,
-0.006542861461639404,
0.020442616194486618,
0.03819219395518303,
-0.00988467875868082,
0.008568761870265007,
-0.038412533700466156,
0.0179331935942173,
-0.012387980706989765,
-0.019793838262557983,
0.028007609769701958,
0.006037916522473097,
-0.009407276287674904,
0.010766036808490753,
0.007381375879049301,
-0.012951071374118328,
-0.0002134539681719616,
-0.03407919034361839,
-0.037359800189733505,
0.0012485909974202514,
-0.009854075498878956,
0.003298973198980093,
0.015154466964304447,
0.008917632512748241,
-0.006273557431995869,
0.019549017772078514,
-0.009786750189960003,
0.0037641345988959074,
-0.025008542463183403,
-0.051167748868465424,
-0.00794446561485529,
-0.021115876734256744,
-0.05944272130727768,
0.006591825745999813,
0.0159746203571558,
0.019451089203357697,
0.01706407591700554,
0.0125838378444314,
0.0017780179623514414,
0.015864450484514236,
-0.02197275310754776,
-0.0032836718019098043,
0.03177786245942116,
-0.010692589916288853,
-0.011457658372819424,
0.02986825443804264,
0.01277969591319561,
0.0017504756106063724,
0.03101891651749611,
0.0075833541341125965,
-0.019536776468157768,
0.020307965576648712,
-0.027052804827690125,
0.0013717669062316418,
0.010049933567643166,
-0.00981123186647892,
0.07893053442239761,
-0.0071181925013661385,
0.0034213841427117586,
0.011671877466142178,
0.005716587882488966,
0.0018958385335281491,
-0.004568986129015684,
0.0037488332018256187,
-0.01124343927949667,
-0.03373643755912781,
0.021140359342098236,
0.0186921413987875,
0.021862583234906197,
0.04081178829073906,
0.030749613419175148,
-0.009217538870871067,
0.004161969758570194,
0.035792939364910126,
-0.028742074966430664,
-0.0017305838409811258,
-0.019695909693837166,
0.004186451900750399,
-0.024763720110058784,
0.031067881733179092,
-0.007852657698094845,
-0.0012195183662697673,
0.006732598412781954,
-0.010105017572641373,
-0.0008102069841697812,
-0.02073640190064907,
-0.0019983574748039246,
-0.012351257726550102,
0.029574468731880188,
-0.023233585059642792,
0.00970718264579773,
0.014628100208938122,
0.0015944016631692648,
-0.044777899980545044,
-0.006689754314720631,
0.006891732569783926,
0.005315692164003849,
0.026049034669995308,
-0.0031046459916979074,
0.012032989412546158,
0.01557066384702921,
0.03177786245942116,
-0.013257098384201527,
0.012387980706989765,
0.031753383576869965,
-0.03258577734231949,
0.01856973022222519,
0.0022248176392167807,
0.011702479794621468,
0.00042499526171013713,
-0.02766485884785652,
0.006463294383138418,
0.028913449496030807,
0.010233549401164055,
-0.011763685382902622,
-0.014224143698811531,
-0.00006005783870932646,
0.024824926629662514,
0.03922044485807419,
-0.01208807434886694,
0.019659187644720078
] | 2025-01-14 | 64 | 39806405 | [
"MM cells",
"MM cell lines",
"T cells",
"SupT-1 cells",
"current MM treatments",
"MM",
"Bispecific T-cell",
"clinical challenges",
"an incurable plasma cell malignancy",
"significant anti-tumor activity",
"continuous infusion",
"antigen loss",
"CAR) T-cell therapy",
"αB7-H3-αCD3 ENG T cells",
"relapsed or refractory MM",
"Chimeric antigen receptor",
"B7-H3 expression levels",
"B7-H3-positive MM",
"potential toxicities",
"overall outcomes",
"αB7-H3-αCD3 ENG-T cells",
"global incidence",
"Multiple myeloma",
"Additional preclinical and clinical research",
"B7-H3",
"half",
"resistance",
"efficacy",
"B7-H3\nThe αB7-H3-αCD3 ENG-T cells",
"BCMA"
] | [
"B7-H3",
"BITE",
"Bispecific T-cell engager",
"CD276",
"ENG T cells",
"Multiple myeloma",
"T cells secreting BITE"
] | 0 | 10.1186/s12967-024-05923-z | [
"Rujirachaivej",
"Siriboonpiputtana",
"Choomee",
"Supimon",
"Sangsuwannukul",
"Songprakhon",
"Natungnuy",
"Luangwattananun",
"Yuti",
"Junking",
"Yenchitsomanus"
] | [
"Graduate Program in Clinical Pathology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.",
"Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.",
"Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.\nDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.",
"Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.\nDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.",
"Department of Molecular Medicine, Mayo Clinic Rochester, Rochester, MN, USA.",
"Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.\nDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.",
"Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.\nDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.",
"Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.\nDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.",
"Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.\nDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.",
"Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. [email protected].\nDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. [email protected].",
"Siriraj Center of Research Excellence for Cancer Immunotherapy (SiCORE-CIT), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. [email protected].\nDivision of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. [email protected]."
] | [
"39806405",
"28726797",
"33498356",
"35560063",
"27705267",
"33918370",
"28688533",
"21187443",
"25287778",
"31042825",
"35658469",
"33626253",
"34175021",
"33272302",
"37507805",
"33922005",
"37591844",
"33941237",
"28249141",
"36941881",
"37982732",
"37497430",
"27209293",
"26607163",
"23623807",
"25142939",
"35312724",
"33051306",
"32346608",
"34562306",
"33141349",
"26487718",
"38744221",
"34265844",
"23986568",
"32898244",
"33558511",
"33619368",
"31558469",
"30918018",
"36060553",
"29972754",
"37653344",
"36284349",
"38250867",
"30573782",
"27208063",
"33514401",
"36159778",
"28938530",
"26976826",
"32221812",
"20350610",
"31832058",
"35570396",
"35899386",
"28837681",
"27780867",
"31451445",
"32242094",
"31332324",
"29588544",
"31189721",
"31940268"
] | [] | 4.824218 | 6.221375 |
39805956 | 35 | ETV7 limits the antiviral and antitumor efficacy of CD8 | Terminal exhaustion is a critical barrier to antitumor immunity. By integrating and analyzing single-cell RNA-sequencing and single-cell assay for transposase-accessible chromatin with sequencing data, we found that ETS variant 7 (ETV7) is indispensable for determining CD8 | [
0.003866758896037936,
0.02595425210893154,
0.057287223637104034,
0.04925774782896042,
-0.03723926842212677,
-0.0032121120020747185,
0.03844883665442467,
0.044856976717710495,
-0.009637944400310516,
-0.017088372260332108,
0.022068191319704056,
0.0630519762635231,
0.01823360100388527,
-0.021669290959835052,
0.003017487470060587,
-0.007810724433511496,
0.04758493974804878,
0.023213420063257217,
-0.003419604618102312,
0.07288293540477753,
0.03386791795492172,
-0.011278582736849785,
0.009284081868827343,
-0.007109432015568018,
-0.006974320393055677,
0.006871378514915705,
0.001926945522427559,
0.03065098077058792,
0.004741766024380922,
-0.04925774782896042,
0.025117848068475723,
-0.03281276300549507,
0.005414105951786041,
-0.014321805909276009,
-0.009039594791829586,
0.000821525405626744,
0.051393792033195496,
-0.0014789870474487543,
-0.03886060416698456,
-0.0163420420140028,
0.06835348904132843,
-0.017744626849889755,
0.0059609850868582726,
0.08003740757703781,
-0.02205532416701317,
-0.049412161111831665,
-0.02877228893339634,
-0.0436474084854126,
0.023715263232588768,
-0.022492827847599983,
0.0360039658844471,
0.005928815808147192,
-0.009264780208468437,
0.034871604293584824,
-0.040121644735336304,
-0.019996482878923416,
-0.04179445281624794,
0.03875766322016716,
0.011626011691987514,
-0.02591564878821373,
-0.01120781060308218,
-0.006575420033186674,
0.016535058617591858,
-0.023419305682182312,
-0.03981281816959381,
-0.0013470925623551011,
-0.034871604293584824,
-0.05237174406647682,
0.003474292578175664,
-0.06150784343481064,
-0.032787028700113297,
-0.054250434041023254,
-0.022261207923293114,
0.035000279545784,
0.07272852212190628,
-0.016277704387903214,
-0.01558284554630518,
0.02181083709001541,
-0.012282267212867737,
-0.03682750090956688,
0.0511879101395607,
0.014308937825262547,
0.018375147134065628,
-0.036750294268131256,
0.008865879848599434,
0.018104923889040947,
0.01814352720975876,
-0.04758493974804878,
-0.051445264369249344,
-0.014694970101118088,
-0.025349467992782593,
0.02486049383878708,
-0.008499149233102798,
0.052448950707912445,
-0.019674789160490036,
-0.004584135953336954,
0.026456093415617943,
-0.0739123523235321,
-0.008035910315811634,
0.011317186057567596,
0.0017837918130680919,
0.02118031680583954,
0.00730888219550252,
-0.08261095732450485,
0.008396206423640251,
-0.02600572258234024,
-0.052217330783605576,
0.004523014184087515,
0.012205060571432114,
-0.0413312129676342,
0.07499324530363083,
-0.00653681717813015,
-0.03628705441951752,
0.03361056372523308,
-0.011600276455283165,
-0.000008375346624234226,
-0.022029587998986244,
0.003664091695100069,
0.04539742320775986,
0.07370647042989731,
0.026533300057053566,
0.03564366698265076,
-0.01203778013586998,
-0.010995492339134216,
-0.0047900197096168995,
-0.058573998510837555,
0.007733517792075872,
0.004600220825523138,
-0.05476514250040054,
-0.03319879621267319,
0.05394160747528076,
-0.015467035584151745,
0.06608876585960388,
0.040121644735336304,
-0.013170141726732254,
-0.024616004899144173,
-0.006189387757331133,
0.014527689665555954,
-0.013729888945817947,
0.006237641908228397,
0.019597582519054413,
0.022209735587239265,
0.013601211830973625,
0.03474292531609535,
-0.025799838826060295,
-0.049926869571208954,
0.005034507252275944,
0.05347836762666702,
0.02702227421104908,
0.035926759243011475,
0.022865992039442062,
0.006437092088162899,
0.038912076503038406,
-0.014978061430156231,
0.005526698660105467,
-0.056926924735307693,
0.0108861168846488,
0.048588622361421585,
-0.0030834346543997526,
-0.010944020934402943,
-0.012488150969147682,
-0.009432060644030571,
0.009116800501942635,
0.02168215811252594,
-0.007913665845990181,
0.04395623505115509,
0.008389772847294807,
0.03605543449521065,
-0.051625411957502365,
0.015531374141573906,
-0.02702227421104908,
-0.049232009798288345,
-0.030676715075969696,
-0.006903547793626785,
-0.039890024811029434,
-0.042000334709882736,
-0.0022052107378840446,
0.04542315751314163,
-0.043467260897159576,
-0.03152598813176155,
0.005385153461247683,
0.02761419117450714,
0.008833710104227066,
0.02118031680583954,
-0.019301624968647957,
-0.04202607274055481,
0.020138029009103775,
0.03602970018982887,
-0.04966951534152031,
-0.008557053282856941,
-0.013266650028526783,
0.040533412247896194,
0.06531669944524765,
0.013305253349244595,
-0.003146164817735553,
-0.013781360350549221,
0.04681287333369255,
0.03325026482343674,
-0.002428787760436535,
0.004165933933109045,
-0.01937883161008358,
0.030959807336330414,
-0.031551722437143326,
-0.027768604457378387,
-0.04259225353598595,
-0.008659996092319489,
-0.013678418472409248,
0.0026201955042779446,
-0.02443585731089115,
0.012700469233095646,
0.02568402886390686,
0.019777731969952583,
-0.032195109874010086,
0.00012867749319411814,
0.01804058626294136,
-0.005591037217527628,
0.0206141360104084,
0.02025383897125721,
0.07277999073266983,
0.025838442146778107,
0.01180616021156311,
0.0025735499802976847,
0.013948640786111355,
0.014656366780400276,
0.0009530177339911461,
-0.004735331982374191,
0.06191961467266083,
-0.03507748618721962,
-0.0015972094843164086,
0.012230796739459038,
0.000678371696267277,
0.003313445718958974,
-0.006716965697705746,
-0.023650923743844032,
-0.05399307981133461,
-0.011986308731138706,
-0.016097554937005043,
0.008833710104227066,
0.013536873273551464,
0.007765687070786953,
-0.0147335734218359,
0.0008758112089708447,
0.02118031680583954,
0.017229916527867317,
-0.046555519104003906,
0.006762002594769001,
0.003709128824993968,
-0.0804491713643074,
-0.0360039658844471,
0.006845642812550068,
-0.03196348994970322,
0.0436474084854126,
0.04238636791706085,
-0.014103054068982601,
-0.004503712523728609,
0.019275888800621033,
0.05159967765212059,
-0.009078197181224823,
0.008454111404716969,
-0.029106849804520607,
0.015750126913189888,
0.013125104829668999,
-0.033584825694561005,
-0.027408307418227196,
-0.02836052142083645,
-0.0008062449633143842,
0.05041584372520447,
0.011503768153488636,
0.017757495865225792,
0.0027810423634946346,
0.025207921862602234,
0.00451014656573534,
-0.00872433464974165,
0.008621392771601677,
-0.04542315751314163,
-0.003535414347425103,
0.012854882515966892,
0.01275194063782692,
-0.04166577383875847,
0.020150896161794662,
-0.021013036370277405,
0.004136981442570686,
-0.037908390164375305,
0.004928348120301962,
-0.03206643462181091,
-0.019636185839772224,
-0.055022500455379486,
0.040018703788518906,
0.005494529381394386,
-0.010094749741256237,
0.04570624977350235,
0.003009445033967495,
0.035051751881837845,
-0.02127039059996605,
-0.04019885137677193,
-0.014630631543695927,
0.03963267058134079,
-0.021424803882837296,
-0.026173003017902374,
0.0077399518340826035,
-0.01855529472231865,
0.004143415484577417,
-0.011587409302592278,
-0.03916943073272705,
0.004683861043304205,
0.0434415228664875,
0.011143471114337444,
-0.012932089157402515,
-0.020318176597356796,
0.07499324530363083,
0.02287885919213295,
-0.03023921325802803,
-0.015943141654133797,
0.020240969955921173,
0.007315315771847963,
-0.0336877703666687,
-0.020472589880228043,
-0.035051751881837845,
0.00752763357013464,
-0.055022500455379486,
-0.021373333409428596,
-0.0488717146217823,
-0.048717301338911057,
0.02877228893339634,
0.02877228893339634,
0.009773056022822857,
-0.020150896161794662,
0.003419604618102312,
0.042695194482803345,
0.006704097613692284,
0.023097611963748932,
-0.043750349432229996,
0.03631278872489929,
-0.026533300057053566,
0.02325202338397503,
-0.05195997282862663,
-0.07689767330884933,
0.037908390164375305,
0.040430471301078796,
0.041305478662252426,
-0.04279813542962074,
-0.010506518185138702,
-0.041820187121629715,
-0.015569977462291718,
0.03795986250042915,
0.027768604457378387,
-0.03687897324562073,
-0.02260863594710827,
0.032889969646930695,
-0.007051527034491301,
0.009187573567032814,
0.022840255871415138,
-0.0029708417132496834,
-0.007585538551211357,
-0.016856752336025238,
-0.015569977462291718,
-0.015428432263433933,
-0.028849495574831963,
-0.009785924106836319,
0.02080715261399746,
-0.004256008192896843,
-0.003146164817735553,
0.017731759697198868,
0.021514877676963806,
0.039375316351652145,
0.03196348994970322,
-0.029209792613983154,
0.0048929620534181595,
-0.06300050765275955,
-0.03541204705834389,
0.003715562867000699,
0.019082874059677124,
0.0024432640057057142,
-0.006774870213121176,
-0.05316954478621483,
0.005253259092569351,
0.025400938466191292,
0.016239101067185402,
0.029209792613983154,
0.02439725399017334,
0.04604081064462662,
0.0479709729552269,
-0.013047898188233376,
-0.06058136746287346,
-0.036389995366334915,
0.008319000713527203,
0.011387959122657776,
-0.04647831246256828,
-0.08750069886445999,
-0.01383283082395792,
0.034820131957530975,
-0.012925654649734497,
0.005362635012716055,
0.010178389959037304,
-0.009869564324617386,
0.01726851984858513,
-0.014296070672571659,
0.08096387982368469,
0.04611801728606224,
-0.002258290071040392,
-0.02029244229197502,
-0.031062748283147812,
-0.020511193200945854,
-0.0018127443036064506,
0.024294311180710793,
-0.017114106565713882,
0.03234952315688133,
-0.006935717072337866,
0.03605543449521065,
-0.026996539905667305,
-0.0011138645932078362,
0.017783230170607567,
0.014797912910580635,
0.02836052142083645,
0.02186230756342411,
-0.043750349432229996,
-0.025246525183320045,
0.055125441402196884,
0.0036866103764623404,
0.024294311180710793,
-0.0610446073114872,
-0.0037123458459973335,
-0.018992798402905464,
-0.013562608510255814,
-0.027588456869125366,
-0.017513006925582886,
0.01726851984858513,
-0.026070062071084976,
0.018117792904376984,
-0.05183129757642746,
0.004400770645588636,
0.0048929620534181595,
-0.03319879621267319,
0.02673918381333351,
-0.0015031140064820647,
0.026893597096204758,
-0.01841375045478344,
0.029518619179725647,
-0.034228213131427765,
0.008254661224782467,
-0.0162905715405941,
0.006047842558473349,
-0.03659588098526001,
-0.044676829129457474,
-0.016856752336025238,
0.015183945186436176,
-0.004995903931558132,
-0.026108665391802788,
-0.014103054068982601,
0.037084855139255524,
0.02573549933731556,
-0.035798080265522,
-0.02573549933731556,
0.05322101339697838,
-0.03803706914186478,
-0.051445264369249344,
0.016779545694589615,
-0.041356947273015976,
0.035798080265522,
0.020035086199641228,
0.02320055291056633,
-0.03705912083387375,
-0.01226940006017685,
0.006565769203007221,
-0.010596591979265213,
0.03204069659113884,
-0.006710531655699015,
-0.011272149160504341,
0.03649294003844261,
0.0031558156479150057,
0.017422933131456375,
-0.03175760805606842,
0.0016872837441042066,
-0.03034215420484543,
-0.01403871551156044,
-0.001607664511539042,
0.015338357537984848,
0.01019769161939621,
-0.012153590098023415,
-0.037625301629304886,
-0.025619689375162125,
-0.035463519394397736,
-0.048357006162405014,
-0.01033280324190855,
0.05934606119990349,
0.0359010212123394,
-0.010442178696393967,
0.010686666704714298,
-0.026173003017902374,
0.019957879558205605,
0.022351281717419624,
-0.018027717247605324,
0.036981914192438126,
-0.013202311471104622,
-0.0008565096068195999,
0.014746441505849361,
0.017101239413022995,
0.00782359205186367,
-0.013948640786111355,
0.025992855429649353,
-0.02684212662279606,
-0.022685842588543892,
0.017435802146792412,
-0.006443525664508343,
0.018928460776805878,
0.022209735587239265,
0.0393238440155983,
0.062485795468091965,
0.03909222409129143,
0.00043710137833841145,
-0.01259109377861023,
-0.0025220790412276983,
0.021244654431939125,
-0.00897525530308485,
-0.05311807245016098,
-0.009573605842888355,
0.005716498009860516,
0.0076498775742948055,
-0.005410888697952032,
-0.012739072553813457,
-0.022312678396701813,
-0.0058580432087183,
-0.011883366852998734,
-0.0011130603961646557,
0.008132417686283588,
-0.05167688429355621,
-0.004564834292978048,
-0.04758493974804878,
-0.04856288805603981,
-0.05152247101068497,
0.00621512345969677,
-0.054198961704969406,
0.032014962285757065,
0.019906409084796906,
0.00003644187017926015,
0.005201788153499365,
0.0033005778677761555,
0.01726851984858513,
-0.03453703969717026,
-0.015750126913189888,
0.011387959122657776,
0.008235359564423561,
0.03759956732392311,
-0.007752819452434778,
0.0031300801783800125,
0.026314549148082733,
-0.015286887064576149,
-0.014231731183826923,
0.006231207866221666,
-0.016959695145487785,
-0.007868628948926926,
-0.03644146770238876,
0.003557932795956731,
-0.02311047911643982,
-0.008447677828371525,
-0.0030383975245058537,
-0.018696840852499008,
-0.022312678396701813,
0.006443525664508343,
0.024242840707302094,
-0.03584955260157585,
-0.0008086576708592474,
0.034588512033224106,
-0.028875231742858887,
0.011735388077795506,
0.0006437895935960114,
-0.03111421875655651,
0.0035868852864950895,
0.009477097541093826,
0.010615893639624119,
-0.029029643163084984,
-0.017603082582354546,
-0.03322453051805496,
-0.017924776300787926,
0.05147099867463112,
0.0003281276149209589,
-0.012507452629506588,
0.006929283495992422,
-0.006903547793626785,
-0.01698542945086956,
-0.00720593985170126,
0.008904483169317245,
-0.003905362216755748,
0.029029643163084984,
-0.022081058472394943,
0.0016197280492633581,
0.006379187107086182,
-0.0021537395659834146,
-0.05126511678099632,
-0.002782650990411639,
0.03664735332131386,
0.010114051401615143,
0.042231954634189606,
-0.008248227648437023,
0.0002253866841783747,
0.011754689738154411,
0.002938672434538603,
-0.03211790323257446,
-0.021836571395397186,
-0.016419248655438423,
0.024963434785604477,
-0.030187740921974182,
0.01914721168577671,
-0.04588639736175537,
-0.009271213784813881,
0.014720706269145012,
-0.0146821029484272,
0.016329174861311913,
-0.018542427569627762,
-0.006546468008309603,
0.05919165164232254,
0.005668243858963251,
-0.04418785497546196,
-0.024744683876633644,
0.028695082291960716,
0.030805394053459167,
-0.013382459990680218,
-0.019134344533085823,
-0.009354854002594948,
0.008499149233102798,
-0.010474348440766335,
-0.002666841261088848,
-0.028592141345143318,
-0.042283426970243454,
-0.0067941718734800816,
-0.028206108137965202,
0.0008006152929738164,
0.010905418545007706,
-0.0014524472644552588,
0.010718835517764091,
0.01493945810943842,
0.011523069813847542,
-0.007540501654148102,
-0.007070828694850206,
0.00013269866758491844,
-0.024500196799635887,
-0.01072527002543211,
-0.006671928334981203,
-0.033764977008104324,
-0.03870619088411331,
-0.0025011689867824316,
0.005655376240611076,
0.011220677755773067,
0.01952037587761879,
0.008061645552515984,
-0.013125104829668999,
0.0030142704490572214,
-0.027536984533071518,
0.01265543233603239,
-0.0009715151390992105,
-0.03373923897743225,
-0.027408307418227196,
0.024320047348737717,
0.0014637066051363945,
0.01937883161008358,
-0.018979931250214577,
-0.007913665845990181,
-0.041588567197322845,
0.04027605801820755,
0.04560330510139465,
0.002644322579726577,
0.013022162951529026,
0.0033166625071316957,
-0.01461776439100504,
0.008775805123150349,
0.0014902462717145681,
0.024036956951022148,
-0.026661977171897888,
-0.011336487717926502,
-0.026108665391802788,
0.03628705441951752,
-0.010648063383996487,
0.02532373182475567,
-0.005899863317608833,
0.05924312025308609,
-0.002237380016595125,
0.012121420353651047,
-0.007778554689139128,
-0.050750404596328735,
-0.016046084463596344,
-0.00907176360487938,
0.0037477321457117796,
-0.02457740157842636,
0.0014524472644552588,
-0.012089251540601254,
-0.011651747860014439,
0.00267005804926157,
-0.024924831464886665,
-0.007784988731145859,
-0.009078197181224823,
0.009432060644030571,
-0.005899863317608833,
0.0006695251213386655,
0.005092412233352661,
-0.027125217020511627,
-0.005825873930007219,
0.003689827397465706,
0.021695027127861977,
-0.02214539796113968,
0.017319992184638977,
0.006768436636775732,
0.034176744520664215,
-0.015274018980562687,
0.007617707829922438,
-0.009535002522170544,
-0.011137037537992,
-0.02384394034743309,
-0.030908335000276566,
0.009123235009610653,
0.0022808087524026632,
-0.016509322449564934,
0.008717901073396206,
-0.011439429596066475,
-0.024924831464886665,
-0.038731928914785385,
-0.012243663892149925,
-0.031217161566019058,
0.035514991730451584,
0.018542427569627762,
-0.0031477734446525574,
0.02246709167957306,
0.004600220825523138,
-0.028180371969938278,
-0.01342106331139803,
0.037676770240068436,
0.00913610216230154,
0.0020009351428598166,
0.03023921325802803,
-0.01822073385119438,
0.006128265988081694,
0.019391698762774467,
-0.05368425324559212,
-0.02098730020225048,
-0.02329062670469284,
0.020562663674354553,
0.031268633902072906,
-0.01814352720975876,
-0.021695027127861977,
-0.01412878930568695,
-0.008454111404716969,
0.024513063952326775,
-0.04737905412912369,
0.0012554099084809422,
0.010094749741256237,
-0.0218237042427063,
0.020871490240097046,
-0.01403871551156044,
0.02164355479180813,
0.01374275702983141,
-0.049051862210035324,
0.0022277291864156723,
0.010763872414827347,
-0.01804058626294136,
-0.04161430522799492,
0.027511250227689743,
-0.02913258597254753,
0.022171134129166603,
0.029930386692285538,
0.011130603961646557,
-0.0089495200663805,
-0.032658349722623825,
0.00718020461499691,
0.025259392336010933,
0.009200441651046276,
0.006691229995340109,
0.01730712316930294,
-0.01689535565674305,
-0.010577290318906307,
-0.002258290071040392,
0.057184282690286636,
-0.02541380561888218,
-0.013318121433258057,
0.020279573276638985,
-0.03986429050564766,
-0.01823360100388527,
0.03023921325802803,
-0.04259225353598595,
-0.007218807935714722,
-0.009271213784813881,
0.0017001514788717031,
-0.00004646966772270389,
0.007585538551211357,
-0.0007539697107858956,
-0.0035161126870661974,
-0.012777675874531269,
-0.011278582736849785,
-0.009959638118743896,
0.02959582582116127,
-0.021707894280552864,
-0.0065593356266617775,
-0.02895243838429451,
0.01919868215918541,
-0.002803561044856906,
0.026661977171897888,
0.03188628330826759,
0.010950455442070961,
0.024641741067171097,
-0.1174568235874176,
0.011413694359362125,
-0.043518729507923126,
0.003374567488208413,
0.006485345773398876,
0.008106682449579239,
0.004773935303092003,
0.02466747723519802,
0.008923784829676151,
0.007591972593218088,
-0.007965137250721455,
0.015557109378278255,
0.026456093415617943,
-0.03515469282865524,
0.006366319488734007,
-0.00528221158310771,
-0.008254661224782467,
-0.005420539528131485,
-0.01406445074826479,
0.012616829015314579,
-0.030599510297179222,
0.03927237167954445,
0.004770718514919281,
0.030856864526867867,
-0.026173003017902374,
0.04063635319471359,
-0.026018589735031128,
-0.021115977317094803,
-0.02679065614938736,
0.005208221729844809,
-0.04779082164168358,
0.023084742948412895,
-0.004420072305947542,
0.02900390885770321,
-0.0008183085010387003,
-0.032787028700113297,
0.0018304374534636736,
-0.035566460341215134,
0.03134584054350853,
-0.022029587998986244,
0.008235359564423561,
0.0018416966777294874,
0.01010118331760168,
0.026404622942209244,
-0.023277759552001953,
-0.0011661398457363248,
-0.033121589571237564,
0.00141545245423913,
0.004806104581803083,
-0.030625244602560997,
-0.004194886423647404,
0.007701348513364792,
-0.0718020424246788,
-0.004468325991183519,
-0.010480782017111778,
-0.04737905412912369,
0.023457909002900124,
0.044445209205150604,
0.032889969646930695,
0.010126919485628605,
-0.004172367975115776,
0.0006337366648949683,
0.014630631543695927,
-0.0245388001203537,
-0.012513887137174606,
0.005803355015814304,
-0.010532253421843052,
0.03314732387661934,
-0.026713449507951736,
-0.000935324584133923,
-0.0071351672522723675,
0.02103877067565918,
-0.06330932676792145,
-0.012372341938316822,
0.00318798515945673,
-0.019597582519054413,
0.005539566278457642,
-0.011748256161808968,
-0.029209792613983154,
-0.006903547793626785,
-0.019893541932106018,
-0.00068038230529055,
0.04851141571998596,
0.021566348150372505,
-0.01026846468448639,
0.01024272944778204,
0.003171900287270546,
0.005793704651296139,
0.008293264545500278,
0.010860380716621876,
0.03613264113664627,
-0.02237701788544655,
-0.0007909645210020244,
0.02457740157842636,
0.012848448008298874,
-0.0191086083650589,
-0.02918405644595623,
0.02650756575167179,
0.0217722337692976,
0.0036994782276451588,
0.04673566669225693,
-0.021244654431939125,
-0.009406325407326221,
0.00505059165880084,
-0.017783230170607567,
0.003972917795181274,
0.02121892012655735,
-0.012739072553813457,
-0.019597582519054413,
-0.01946890540421009,
0.032478202134370804,
0.05455926060676575,
0.027073746547102928,
-0.028926702216267586,
0.01493945810943842,
0.016097554937005043,
0.040713559836149216,
-0.01891559176146984,
-0.008737201802432537,
-0.02025383897125721,
0.012771242298185825,
0.03299291059374809,
-0.012256531976163387,
-0.01145873125642538,
-0.01768028922379017,
0.02987891621887684,
0.01412878930568695,
0.006459610536694527,
-0.0315774567425251,
-0.025491012260317802,
0.026481829583644867,
0.007276712451130152,
0.0002758523914963007,
-0.03770250827074051,
-0.019353095442056656,
0.038140010088682175,
-0.019121477380394936,
0.03270982205867767,
-0.028514934703707695,
0.0028067780658602715,
0.007424691691994667,
-0.02412703074514866,
-0.01923728547990322,
-0.03391939029097557,
0.008203190751373768,
-0.0036866103764623404,
-0.03273555636405945,
0.020331045612692833,
-0.011523069813847542,
0.0026990105397999287,
0.004268876276910305,
0.015994613990187645,
0.004986253101378679,
0.06274314969778061,
0.01680528186261654,
0.026353152468800545,
0.013472533784806728,
-0.010731703601777554,
-0.0261472687125206,
0.02159208431839943,
-0.02444872446358204,
0.034639984369277954,
-0.03963267058134079,
-0.013356724753975868,
0.04014737904071808,
-0.007006489671766758,
-0.008659996092319489,
0.012069949880242348,
0.030162006616592407,
0.005272560752928257,
0.013961508870124817,
-0.04827979952096939,
0.0423348993062973,
-0.022956065833568573,
-0.021025903522968292,
-0.02586417831480503,
0.02715095318853855,
0.045037124305963516,
0.01914721168577671,
0.03548925369977951,
-0.027073746547102928,
0.016509322449564934,
0.013614079914987087,
0.021411936730146408,
0.012114986777305603,
0.005131015088409185,
0.01771889254450798,
-0.005269343499094248,
0.031088484451174736,
0.011542371474206448,
-0.0012594310101121664,
-0.023959750309586525,
0.03116569109261036,
0.008370471186935902,
0.020910093560814857,
-0.014553424902260303,
-0.011349355801939964,
0.006038191728293896,
-0.021206051111221313,
-0.020150896161794662,
-0.001168552553281188,
0.011664615012705326,
0.06052989512681961,
-0.032658349722623825,
-0.014514821581542492,
0.03142304718494415,
0.013080067932605743,
-0.019816335290670395,
-0.03029068373143673,
0.003307011676952243,
0.028180371969938278,
0.046246692538261414,
0.003213720628991723,
0.02121892012655735,
-0.014759309589862823,
-0.004461892414838076,
0.020588399842381477,
-0.015479903668165207,
-0.02720242366194725,
-0.007669178768992424,
0.008614958263933659,
-0.016547925770282745,
0.05934606119990349,
-0.00492513133212924,
0.0013197485823184252,
0.030264947563409805,
0.02650756575167179,
0.010236294940114021,
-0.0015738867223262787,
0.013382459990680218,
-0.032426729798316956,
-0.009084631688892841,
0.010255596600472927,
0.017976246774196625,
-0.004970168229192495,
-0.00881440844386816,
0.0031027363147586584,
-0.01564718410372734,
0.01605895161628723,
-0.01716557890176773,
0.038551777601242065,
-0.02241562120616436,
0.030548037961125374,
-0.025027774274349213,
-0.011349355801939964,
0.017204182222485542,
0.04516580328345299,
-0.01757734641432762,
0.017603082582354546,
-0.0016285745659843087,
-0.01265543233603239,
-0.02269871160387993,
0.015634316951036453,
0.026314549148082733,
0.042643722146749496,
0.019250154495239258,
0.0025815924163907766,
-0.011896234937012196,
0.014579161070287228,
0.0026201955042779446,
0.006909981835633516,
-0.021566348150372505,
-0.018027717247605324,
0.0071480353362858295,
0.016354911029338837,
-0.0325811430811882,
-0.015492770820856094,
-0.02738257125020027,
-0.003583668265491724,
0.019867805764079094,
0.022763049229979515,
-0.014823648147284985,
0.00042785267578437924,
0.008955953642725945,
0.0004664559382945299,
-0.0005585407488979399,
0.00865356158465147,
0.007334617432206869,
0.011909103021025658,
-0.004468325991183519,
0.015389828942716122,
-0.005639291368424892,
0.039890024811029434,
-0.009200441651046276,
-0.004867226351052523,
0.008125984109938145,
-0.036338526755571365,
-0.03420247882604599,
0.026121532544493675,
-0.02959582582116127,
-0.004928348120301962,
-0.012964257970452309,
-0.022865992039442062,
-0.03011053428053856,
0.0016205322463065386,
0.0004676622920669615,
-0.008923784829676151,
0.01441187970340252,
0.0021826920565217733,
-0.034639984369277954,
-0.004400770645588636,
0.026816390454769135,
0.0008814408793114126,
-0.010216993279755116,
-0.0022438138257712126,
-0.035695139318704605,
-0.02218400128185749,
-0.019674789160490036,
0.03443409875035286,
0.001960723428055644,
-0.03363629803061485,
0.00853775255382061,
0.0119670070707798,
0.021386200562119484,
-0.013047898188233376,
-0.012455982156097889,
0.008087380789220333,
-0.013845698907971382,
0.030264947563409805,
0.016560794785618782,
-0.024191370233893394,
-0.014540557749569416,
0.005259692668914795,
0.006704097613692284,
-0.016535058617591858,
-0.015621448867022991,
0.029621560126543045,
-0.030625244602560997,
0.0015015056123957038,
-0.010918285697698593,
0.04436800256371498,
-0.03582381457090378,
0.014797912910580635,
0.02130899392068386,
0.02577410265803337,
-0.010159088298678398,
0.01868397369980812,
-0.03296717628836632,
-0.018606767058372498,
0.022389885038137436,
-0.02139906771481037,
0.0010382665786892176,
-0.008679297752678394,
0.012777675874531269,
0.015286887064576149,
0.034639984369277954,
-0.005520264618098736,
0.005745450500398874,
-0.009882432408630848,
-0.021373333409428596,
0.05041584372520447,
-0.042875342071056366,
0.00945779588073492,
0.04820259287953377,
0.01943030208349228,
0.0052243066020309925,
-0.007727083750069141,
0.03515469282865524,
-0.0002491115883458406,
0.03070245124399662,
-0.03819148242473602,
0.029570089653134346,
0.027742868289351463,
-0.0391179583966732,
-0.0233807023614645,
-0.0025735499802976847,
-0.03000759333372116,
-0.027871547266840935,
-0.03093407116830349,
0.021000167354941368,
-0.008158153854310513,
0.017435802146792412,
-0.030187740921974182,
0.01081534381955862,
-0.020910093560814857,
-0.00701935775578022,
0.001737146289087832,
0.009348420426249504,
-0.021566348150372505,
0.027588456869125366,
0.02457740157842636,
-0.046890079975128174,
0.015531374141573906,
-0.022248338907957077,
-0.008267529308795929,
-0.014025847427546978,
-0.011387959122657776,
-0.010628761723637581,
-0.016071820631623268,
0.02287885919213295,
-0.016856752336025238,
0.0047095962800085545,
0.013588343746960163,
-0.021849440410733223,
-0.013961508870124817,
0.013858566991984844,
-0.02637888677418232,
0.011445863172411919,
-0.013974376954138279,
0.013691285625100136,
-0.04115106537938118,
-0.026661977171897888,
0.01716557890176773,
-0.028978172689676285,
0.011278582736849785,
-0.01998361572623253,
0.028231844305992126,
0.010435745120048523,
-0.0013446798548102379,
-0.0026539734099060297,
-0.01975199580192566,
0.007495464291423559,
-0.028798025101423264,
0.026687713339924812,
-0.013305253349244595,
0.011465164832770824,
-0.013987244106829166,
-0.03783118352293968,
0.0043846857734024525,
0.000166677578818053,
0.009387023746967316,
-0.003725213697180152,
0.06042695418000221,
-0.007257410790771246,
-0.04148562625050545,
0.026082929223775864,
0.034588512033224106,
0.017667420208454132,
-0.011259281076490879,
0.009374155662953854,
0.017937643453478813,
-0.018014850094914436,
0.003339181188493967,
-0.019636185839772224,
-0.013170141726732254,
0.025439541786909103,
0.0003287307918071747,
-0.010641628876328468,
-0.015865935012698174,
-0.002105485647916794,
-0.014540557749569416,
-0.022312678396701813,
-0.022685842588543892,
0.038500308990478516,
0.03319879621267319,
-0.05165114998817444,
-0.0052114385180175304,
-0.005957768298685551,
0.009580039419233799,
-0.008737201802432537,
-0.006523949094116688,
0.003072175197303295,
-0.0038924943655729294,
0.008151719346642494,
0.00035627582110464573,
-0.031783342361450195,
-0.004629172850400209,
-0.009586473926901817,
0.006839209236204624,
-0.001617315341718495,
-0.024911964312195778,
0.002650756388902664,
0.007109432015568018,
0.008505582809448242,
-0.015209680423140526,
0.049283482134342194,
-0.006871378514915705,
-0.016831016167998314,
-0.05072467029094696,
0.014270334504544735,
0.006343800574541092,
0.024744683876633644,
0.012887051329016685,
-0.016599398106336594,
0.040996652096509933,
-0.025426674634218216,
0.021836571395397186,
0.02513071522116661,
0.009451362304389477,
0.003779901657253504,
0.007012923713773489,
-0.011465164832770824,
0.012153590098023415,
-0.026481829583644867,
0.031834814697504044,
0.031268633902072906,
-0.017088372260332108,
-0.03754809498786926,
0.0223255455493927,
-0.010062580928206444,
-0.004703162703663111,
0.012829146347939968,
-0.04058488458395004,
-0.0015224156668409705,
0.024873360991477966,
0.006864944472908974,
-0.006417790427803993,
-0.00528221158310771,
-0.014630631543695927,
0.005134232342243195,
-0.02807743102312088,
-0.00985026266425848,
-0.014501954428851604,
-0.007090130355209112,
-0.00862782634794712,
0.008325434289872646,
-0.03862898424267769,
-0.02477041818201542,
0.01380709558725357,
0.013022162951529026,
0.023007536306977272,
0.014283202588558197,
0.018761180341243744,
0.038912076503038406,
-0.006411356385797262,
-0.0294671468436718,
-0.050518784672021866,
0.04277240112423897,
0.0024384385906159878,
0.014077318832278252,
-0.01909574121236801,
0.005755101330578327,
0.013356724753975868,
-0.016998298466205597,
0.016213364899158478,
-0.037084855139255524,
0.01993214525282383,
-0.010107617825269699,
-0.0001998522348003462,
0.0026121533010154963,
0.06264020502567291,
0.01730712316930294,
0.006427441257983446,
0.0103585384786129,
-0.0359010212123394,
0.06089019402861595,
-0.008029475808143616,
-0.018864121288061142,
-0.013665550388395786,
-0.014630631543695927,
-0.014000112190842628,
-0.008621392771601677,
0.0031831597443670034,
0.024731814861297607,
-0.010030411183834076,
0.01243024691939354,
-0.004397553391754627,
-0.03955546393990517,
0.007315315771847963,
0.0325811430811882,
0.005829090718179941,
-0.04127974063158035,
0.0069807544350624084,
-0.011413694359362125,
-0.016766678541898727,
-0.0017419717041775584,
0.0029434978496283293,
-0.021334730088710785,
-0.03996723145246506,
-0.004921914543956518,
0.009348420426249504,
0.027048010379076004,
-0.009515700861811638,
-0.013228046707808971,
0.0048929620534181595,
-0.001289991894736886,
0.004963734652847052,
-0.028926702216267586,
-0.04616948589682579,
-0.02673918381333351,
-0.03777971491217613,
-0.03443409875035286,
-0.019713392481207848,
-0.0017451886087656021,
-0.00392466364428401,
0.004732115194201469,
-0.002739222254604101,
-0.017461536452174187,
0.028592141345143318,
-0.03070245124399662,
-0.03973561152815819,
0.030831128358840942,
-0.01593027450144291,
-0.03263261541724205,
0.01403871551156044,
-0.016071820631623268,
-0.03245246410369873,
-0.001944638672284782,
-0.006511081475764513,
-0.012436680495738983,
-0.012764807790517807,
-0.033945124596357346,
0.020150896161794662,
-0.0012087642680853605,
0.004770718514919281,
0.012533188797533512,
0.0031316885724663734,
0.011844763532280922,
-0.00016537070041522384,
0.002715095179155469,
-0.015119606629014015,
-0.011188508942723274,
-0.0007439167820848525,
-0.028463462367653847,
-0.030162006616592407,
0.007746385410428047,
0.008479847572743893,
-0.009682982228696346,
0.008428376168012619,
-0.01643211580812931,
-0.02462887391448021,
-0.01403871551156044,
-0.02237701788544655,
0.003718779655173421,
0.017024032771587372,
0.01620049774646759,
-0.009091065265238285,
0.013228046707808971,
-0.030676715075969696,
0.023419305682182312,
0.023998353630304337,
0.039015017449855804,
-0.010249163024127483,
-0.011426562443375587,
0.038371630012989044,
0.01998361572623253,
-0.0012642564252018929,
0.02600572258234024,
0.007270278874784708,
-0.021733630448579788,
0.018696840852499008,
-0.01596887782216072,
0.024281444028019905,
-0.04452241584658623,
-0.013472533784806728,
-0.035798080265522,
-0.03142304718494415,
0.003438906278461218,
-0.0006550488760694861,
0.016071820631623268,
-0.0152611518278718,
0.023406436666846275,
0.018941327929496765,
0.017139842733740807,
-0.043853290379047394,
-0.008930218406021595,
-0.00798443891108036,
0.006456393748521805,
0.0011170814977958798,
-0.004822189453989267,
-0.01132361963391304,
-0.009766622446477413,
-0.0293642058968544,
0.019481772556900978,
-0.011420127935707569,
0.008389772847294807,
0.01878691464662552,
-0.04050767794251442,
0.016084687784314156,
-0.006063926964998245,
0.023084742948412895,
-0.012526754289865494,
0.0027536984998732805,
0.03041936084628105,
0.007115865591913462,
-0.002111919457092881,
-0.008479847572743893,
0.022775918245315552,
-0.01638064533472061,
0.005771185737103224,
-0.03366203233599663,
0.005333682522177696,
-0.027511250227689743,
0.048073913902044296,
0.08214771747589111,
-0.05031290277838707,
-0.03211790323257446,
-0.0013060766505077481,
0.03448557108640671,
0.03093407116830349,
0.037033382803201675,
0.01116277277469635,
-0.01768028922379017,
0.011156339198350906,
0.020099425688385963,
-0.005771185737103224,
0.0195589791983366,
0.03654440864920616,
0.0239340141415596,
-0.016033217310905457,
-0.01500379666686058,
0.028592141345143318,
-0.022724445909261703,
-0.0078042903915047646,
-0.006108964327722788,
-0.014193127863109112,
-0.027125217020511627,
0.006877812556922436,
-0.022904595360159874,
-0.005256475880742073,
0.0073925224132835865,
-0.03433115780353546,
-0.012095685116946697,
-0.020678473636507988,
-0.005870910827070475,
-0.0007406998774968088,
0.011130603961646557,
-0.03852604329586029,
0.031834814697504044,
-0.004944432992488146,
-0.0027456560637801886,
-0.016818149015307426,
-0.012803411111235619,
-0.0012948173098266125,
0.015081003308296204,
0.010570856742560863,
-0.015428432263433933,
0.021025903522968292,
-0.006955018732696772,
0.0003705509880091995,
-0.02661050669848919,
0.025786971673369408,
0.002213252941146493,
-0.01212785392999649,
-0.014424747787415981,
-0.022801652550697327,
0.006974320393055677,
-0.008415508083999157,
-0.02093582972884178,
-0.032298050820827484,
0.032246582210063934,
0.0030576991848647594,
0.01532549038529396,
-0.05015848949551582,
-0.033173058182001114,
0.015891671180725098,
0.027459777891635895,
-0.011870499700307846,
0.02486049383878708
] | 2025-01-14 | 68 | 39805956 | [
"Terminal exhaustion",
"data",
"transposase-accessible chromatin",
"Terminal",
"immunity",
"RNA",
"single-cell RNA-sequencing and single-cell assay",
"CD8",
"a critical barrier",
"that ETS",
"7",
"we"
] | [] | 0 | 10.1038/s43018-024-00892-0
10.1016/j.immuni.2011.07.010
10.1038/ni.3031
10.1038/2201352a0
10.1016/bs.pmbts.2018.11.002
10.1146/annurev-immunol-041015-055318
10.1038/s41577-021-00574-3
10.1016/j.immuni.2016.07.011
10.1016/j.ccell.2017.02.008
10.1016/j.ccell.2018.03.012
10.1016/j.cell.2018.10.038
10.1038/nature19330
10.1016/j.immuni.2018.12.021
10.1126/science.abb9847
10.1038/s41571-021-00552-7
10.1038/s41571-022-00689-z
10.1038/s41573-021-00189-2
10.1038/s41419-018-0278-6
10.1146/annurev-med-062315-120245
10.1126/science.abe6474
10.1038/s43018-022-00391-0
10.1038/s41587-019-0206-z
10.1038/s41590-020-0725-2
10.1016/j.isci.2018.03.009
10.1038/s41577-019-0221-9
10.1038/s41590-021-00965-7
10.1093/emboj/18.12.3419
10.1038/nature22367
10.4049/jimmunol.1501032
10.1111/ctr.13429
10.1016/j.chom.2012.05.003
10.1016/j.it.2017.05.005
10.1093/nar/21.15.3479
10.1038/s41586-019-1324-y
10.1038/346629a0
10.1128/JVI.78.11.5535-5545.2004
10.1073/pnas.1011998107
10.7554/eLife.74443
10.1136/gutjnl-2021-325915
10.1056/NEJMra2212151
10.1002/hep.22881
10.1038/s41375-018-0220-z
10.1038/s41467-021-25539-x
10.1126/scisignal.2004088
10.1158/2159-8290.CD-12-0095
10.1182/blood.V95.11.3341.011k44_3341_3348
10.1038/emboj.2010.106
10.1038/s41591-020-1061-7
10.1073/pnas.2202439119
10.1016/j.celrep.2015.03.015
10.1038/nri.2015.10
10.4049/jimmunol.173.2.969
10.1038/ni1105
10.4049/jimmunol.174.5.2591
10.1016/j.immuni.2015.08.006
10.4110/in.2023.23.e41
10.1074/jbc.M010070200
10.1007/s13277-015-4133-4
10.1038/s41588-021-00790-6
10.1093/bioinformatics/btr064
10.1016/j.cell.2019.05.031
10.1177/0049124103031004005
10.1073/pnas.95.2.669
10.1073/pnas.1512503112
10.1016/j.immuni.2007.09.006
10.1073/pnas.0409763102
10.1038/s41588-018-0204-y
10.1016/j.cmet.2023.04.017
10.1038/s43018-024-00771-8
10.1038/s41586-021-04082-1 | [
"Cheng",
"Xiao",
"Peng",
"Zhang",
"Qin",
"Wang",
"Shi",
"Yan",
"Zhao",
"Zheng",
"He",
"Wang",
"Zhang",
"Li",
"Zhu",
"Jiang"
] | [
"State Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.\nDepartment of Pathology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.",
"State Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.",
"State Key Laboratory of Molecular Oncology, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Molecular Oncology, Peking University Cancer Hospital & Institute, Beijing, China.",
"Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, China.",
"Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.",
"Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, China.",
"State Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.",
"School of Life Sciences, Center for Statistical Science, Peking University, Beijing, China.",
"School of Life Sciences, Center for Statistical Science, Peking University, Beijing, China.",
"State Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.",
"School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.",
"School of Life Sciences, Center for Statistical Science, Peking University, Beijing, China. [email protected].",
"School of Life Sciences, Center for Statistical Science, Peking University, Beijing, China. [email protected].",
"Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, China. [email protected].",
"State Key Laboratory of Molecular Oncology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. [email protected]."
] | [
"39805956",
"21867926",
"25396352",
"4302696",
"31383402",
"30676822",
"34253904",
"27521269",
"28292435",
"29634943",
"30388456",
"27501248",
"30635237",
"33303615",
"34580473",
"36216928",
"33972771",
"29449531",
"27860544",
"34914499",
"35668194",
"31375813",
"32661364",
"30428369",
"31570879",
"34282329",
"10369681",
"28514453",
"27271568",
"30341925",
"22704623",
"28579323",
"8346026",
"31207604",
"1696684",
"15140950",
"21098292",
"35666101",
"35361683",
"19399811",
"30042413",
"34489433",
"23550210",
"22588877",
"10828014",
"20517297",
"33020644",
"35512094",
"25843714",
"26781939",
"15240684",
"15300249",
"15728465",
"26341400",
"37970230",
"11108721",
"26432330",
"33633365",
"21330290",
"31178118",
"9435250",
"26216948",
"17950003",
"15699353",
"30224644",
"37178684",
"38844817",
"34732892"
] | [] | 10.218875 | 5.228067 |
39805660 | 36 | CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors. | Adaptive cellular therapy (ACT), particularly chimeric antigen receptor (CAR)-T cell therapy, has been successful in the treatment of hemopoietic malignancies. However, poor trafficking of administered effector T cells to the tumor poses a great hurdle for this otherwise powerful therapeutic approach in solid cancers. Our previous study revealed that targeting CD93 normalizes tumor vascular functions to improve immune checkpoint blockade therapy. The objective of this study is to evaluate whether CD93 blockade improves ACT in solid cancers.
Monoclonal antibodies (mAbs) against CD93 or IGFBP7 were administered in implanted mouse melanoma models to assess the effect of CD93 blockade on ACT. Different sources of effector T cells were used, including pre-activated CD8+OT-1, pmel-1 transgenic T cells, and CAR-T cells. Rip-OVA and Rip-TAG-OVA transgenic mice were used to evaluate the selective impact of CD93 blockade on effector T-cell infiltration in tumors. For mechanistic studies, vascular maturation was determined by immunofluorescent staining and flow cytometry was performed to examine tumor-infiltrating T lymphocytes. Neutralizing mAbs against adhesion molecules ICAM1 and VCAM1 were infused to assess their involvement.
Blockade of the CD93 pathway increases the expression of adhesion molecules on tumor vasculature to improve effector T-cell infiltration and function. T-cell transfer and CD93 blockade synergistically improve tumor vascular maturation, as well as inhibit tumor progression. Anti-CD93 selectively promotes effector T-cell infiltration in a tumorous setting where the CD93 pathway is upregulated. In a solid mouse tumor model, blockade of the CD93 pathway improves CAR-T therapy.
CD93 blockade normalizes tumor vasculature leading to improved effector T-cell infiltration and function in solid cancers. Our study advocates the application of CD93 blockade for ACT in solid cancers. | [
0.02905958704650402,
0.0217145849019289,
-0.0013263520086184144,
0.0579712875187397,
-0.003962110728025436,
-0.035665158182382584,
0.03827781230211258,
0.009316814132034779,
0.018005112186074257,
-0.0024647656828165054,
-0.0008950180490501225,
0.0036509342025965452,
-0.05264739319682121,
0.006519305054098368,
0.03140111267566681,
-0.018251590430736542,
0.032411668449640274,
-0.013778040185570717,
0.027063127607107162,
0.058414947241544724,
0.031105343252420425,
0.02989760786294937,
-0.009446213953197002,
-0.0010375123238191009,
-0.000175903391209431,
-0.011257817037403584,
0.020063191652297974,
0.028517339378595352,
0.008947099559009075,
-0.04291157051920891,
0.05708397179841995,
-0.01851039007306099,
-0.013346705585718155,
-0.005505670327693224,
-0.016353720799088478,
0.02573215402662754,
-0.015984004363417625,
-0.000299430510494858,
-0.027703965082764626,
-0.0053362175822257996,
0.009649557061493397,
-0.0015620451886206865,
0.005280760582536459,
0.09686528891324997,
-0.06861907243728638,
0.005326974671334028,
0.0238589309155941,
-0.0758654847741127,
-0.0035184528678655624,
0.010789511725306511,
0.0017792526632547379,
0.017512159422039986,
-0.02454906515777111,
0.03980596363544464,
-0.03736584633588791,
0.049812912940979004,
-0.01864595152437687,
0.027408193796873093,
-0.023316683247685432,
-0.006734972354024649,
-0.027161717414855957,
0.0018978695152327418,
0.03517220541834831,
-0.03586234152317047,
-0.042196787893772125,
0.017154768109321594,
-0.06807682663202286,
-0.04480943828821182,
-0.001985676819458604,
-0.04599252715706825,
-0.0010290396166965365,
-0.0554572269320488,
-0.005499508231878281,
-0.011066798120737076,
-0.0015166010707616806,
-0.0007544493419118226,
-0.01970580220222473,
0.036084167659282684,
0.00648233387619257,
-0.04956643655896187,
0.04138341546058655,
-0.00790573563426733,
0.021591346710920334,
-0.05456991121172905,
-0.0030409046448767185,
0.004458144772797823,
0.0024940348230302334,
-0.025128286331892014,
-0.04214749112725258,
0.003641691291704774,
0.0392390675842762,
0.04130947217345238,
-0.053140345960855484,
0.04456296190619469,
0.00821383111178875,
-0.010524549521505833,
-0.01970580220222473,
-0.07966122776269913,
0.04623900353908539,
0.03487643226981163,
0.035665158182382584,
-0.009267519228160381,
0.02080262266099453,
-0.013322058133780956,
0.035541921854019165,
0.0042794495820999146,
-0.012391609139740467,
-0.002236774889752269,
0.024043789133429527,
-0.02836945280432701,
0.07828095555305481,
-0.00476624071598053,
0.0029530972242355347,
0.05866142362356186,
-0.010832644999027252,
-0.051069945096969604,
0.013285086490213871,
-0.005835332442075014,
0.005092822015285492,
0.009415404871106148,
-0.017857227474451065,
0.01963185891509056,
0.008164536207914352,
-0.02649623155593872,
0.010530711151659489,
-0.0396580807864666,
0.09745683521032333,
-0.03625670447945595,
-0.04377423971891403,
-0.05240091681480408,
0.04029892012476921,
-0.0037834153044968843,
0.04389747604727745,
-0.021455785259604454,
-0.04207354784011841,
0.0070862011052668095,
0.022860702127218246,
-0.0047323498874902725,
-0.04658406972885132,
-0.015910062938928604,
0.004636840429157019,
-0.005249951034784317,
-0.016452310606837273,
-0.044686201959848404,
-0.022577254101634026,
-0.0362074077129364,
-0.014579088427126408,
0.0015366273000836372,
0.0018393313512206078,
0.014505146071314812,
-0.0070553915575146675,
0.05195726081728935,
0.05792199447751045,
-0.022515634074807167,
-0.010469092056155205,
-0.013876630924642086,
0.007708554621785879,
0.058907900005578995,
-0.018978696316480637,
-0.07320354133844376,
-0.02420399896800518,
0.02329203486442566,
-0.022503310814499855,
0.004969583824276924,
-0.011966437101364136,
0.018054408952593803,
-0.041777778416872025,
0.020137134939432144,
-0.062457162886857986,
0.0031025237403810024,
0.0005299246404320002,
-0.0404960997402668,
-0.059252966195344925,
-0.019373057410120964,
-0.05767551437020302,
-0.0127921337261796,
0.0038296296261250973,
0.010851130820810795,
-0.020371288061141968,
-0.019804392009973526,
-0.004846345633268356,
0.038992591202259064,
0.003610881743952632,
0.008158374577760696,
-0.027309603989124298,
0.013198819942772388,
0.006245099939405918,
0.02940465323626995,
-0.04611576348543167,
-0.0011368731502443552,
0.009933005087077618,
0.015688233077526093,
0.03312645107507706,
-0.0020365125965327024,
0.014961127191781998,
-0.014800917357206345,
0.016698786988854408,
0.04761927202343941,
0.007813307456672192,
-0.015417109243571758,
0.046288300305604935,
-0.030144084244966507,
-0.056295245885849,
-0.0166371688246727,
-0.03763697296380997,
-0.00494185509160161,
-0.06186561658978462,
0.040397509932518005,
0.005964732728898525,
0.04190101474523544,
0.06280222535133362,
-0.02329203486442566,
0.014862536452710629,
0.012373123317956924,
0.02170226164162159,
0.000650081958156079,
-0.02543638087809086,
0.06778105348348618,
0.029034938663244247,
0.03591163456439972,
-0.030908161774277687,
-0.021652966737747192,
0.005915437359362841,
0.02765467017889023,
-0.025140609592199326,
0.031105343252420425,
0.028788462281227112,
-0.02795044332742691,
-0.006747296079993248,
-0.051415011286735535,
0.02358780801296234,
0.01976742036640644,
-0.021751556545495987,
-0.02918282523751259,
-0.017278006300330162,
-0.029626483097672462,
-0.017783284187316895,
-0.007363487500697374,
0.03568980470299721,
-0.024019140750169754,
0.0176846943795681,
0.021061422303318977,
0.021135365590453148,
-0.0015196821186691523,
-0.024006817489862442,
-0.02072867937386036,
0.003999082371592522,
-0.09050619602203369,
0.003462995635345578,
0.014098459854722023,
0.0015558833256363869,
-0.005527236964553595,
-0.042122844606637955,
-0.012613438069820404,
-0.004932612180709839,
0.02162831835448742,
0.012219076044857502,
-0.023908227682113647,
-0.0035492624156177044,
-0.01407381147146225,
0.012465552426874638,
0.04882700741291046,
-0.02538708597421646,
-0.042122844606637955,
-0.02933071181178093,
0.008176860399544239,
-0.0014757784083485603,
0.029232120141386986,
-0.0031256310176104307,
0.005986299365758896,
0.0217145849019289,
0.014270992949604988,
0.04480943828821182,
0.00506201246753335,
-0.021184660494327545,
0.04121088236570358,
-0.013679449446499348,
0.0006689528236165643,
0.015047394670546055,
0.021061422303318977,
-0.0014164700405672193,
0.0013640937395393848,
0.02252795733511448,
0.03329898416996002,
-0.0404960997402668,
-0.01192946545779705,
-0.01969347707927227,
0.028960997238755226,
-0.012564143165946007,
0.008780727162957191,
0.02696453593671322,
-0.0031918715685606003,
-0.00919357594102621,
0.014998098835349083,
-0.017733989283442497,
-0.0003487258218228817,
-0.007006096187978983,
-0.018005112186074257,
-0.029577188193798065,
0.017093149945139885,
-0.023107178509235382,
0.017697017639875412,
0.02399449422955513,
-0.012323828414082527,
-0.011319436132907867,
0.038869354873895645,
-0.0196195337921381,
-0.02829550951719284,
0.02030966803431511,
0.022663520649075508,
0.04616506025195122,
-0.012533333152532578,
0.024093084037303925,
0.0430101603269577,
-0.0009443133603781462,
-0.016316749155521393,
0.008965585380792618,
-0.03847499191761017,
0.03635529428720474,
-0.007061553653329611,
-0.03943625092506409,
-0.04005244001746178,
-0.03556656837463379,
0.022441690787672997,
0.016969911754131317,
-0.03660177066922188,
-0.001316338893957436,
-0.018732218071818352,
-0.0007902655052021146,
-0.02377266436815262,
0.03842569515109062,
-0.018978696316480637,
0.07211904227733612,
-0.04695378616452217,
0.022638872265815735,
0.00998230092227459,
-0.03743978962302208,
-0.022022681310772896,
0.014948803931474686,
0.05151360109448433,
-0.0033397574443370104,
0.039017241448163986,
-0.02703847922384739,
0.03689754009246826,
0.009945329278707504,
-0.017278006300330162,
-0.029108881950378418,
0.009273680858314037,
0.03396447002887726,
0.04106299579143524,
0.015688233077526093,
0.01539246179163456,
0.010037758387625217,
0.037193313241004944,
0.0039313011802732944,
-0.0007586856954731047,
-0.01573752798140049,
-0.05693608522415161,
0.008139888755977154,
0.009544804692268372,
-0.005188331473618746,
-0.005696689710021019,
-0.048777710646390915,
0.02753143198788166,
0.05900648981332779,
0.03822851553559303,
-0.04456296190619469,
0.03132717311382294,
-0.03445742279291153,
-0.027580726891756058,
-0.003091740421950817,
0.011473484337329865,
0.03987990692257881,
-0.00662405788898468,
-0.040471453219652176,
0.028394099324941635,
0.013999869115650654,
0.026249753311276436,
0.0077208783477544785,
0.010031595826148987,
0.05885860323905945,
-0.022983940318226814,
0.021233955398201942,
0.009871385991573334,
-0.009834415279328823,
-0.01095588319003582,
0.04458761215209961,
-0.0396580807864666,
-0.06378813832998276,
0.03002084605395794,
0.034556012600660324,
0.003992920275777578,
0.004054539371281862,
0.008158374577760696,
-0.03980596363544464,
0.0028914781287312508,
0.016735758632421494,
0.04318269342184067,
0.037464436143636703,
0.019397705793380737,
-0.0037464438937604427,
-0.024179350584745407,
-0.00707387737929821,
-0.03655247390270233,
0.0302919689565897,
-0.01241009496152401,
0.032855324447155,
0.004775483626872301,
0.00008713331772014499,
-0.000355465424945578,
-0.015712881460785866,
-0.035813044756650925,
0.05047839879989624,
0.026594821363687515,
0.013728744350373745,
-0.0049233692698180676,
-0.008109078742563725,
0.022700492292642593,
-0.008189183659851551,
0.022836053743958473,
-0.003493805415928364,
-0.0127921337261796,
-0.0006531628896482289,
-0.05733044818043709,
-0.009205900132656097,
0.002561815781518817,
0.037760209292173386,
-0.017573779448866844,
-0.011726122349500656,
-0.057034678757190704,
-0.007646935526281595,
0.07719645649194717,
0.02032199315726757,
-0.0014403474051505327,
-0.014726975001394749,
0.03445742279291153,
-0.03337292745709419,
0.0019209766760468483,
-0.03514755889773369,
0.04584464058279991,
-0.022022681310772896,
-0.013543887063860893,
-0.011750769801437855,
-0.0681261196732521,
0.02531314268708229,
0.012003408744931221,
0.04818616807460785,
0.004516683053225279,
-0.0054009174928069115,
0.0024770894087851048,
0.00929216668009758,
-0.0443657822906971,
0.002014945959672332,
0.04796433821320534,
-0.011042149737477303,
0.011134578846395016,
0.06472474336624146,
-0.03430953621864319,
-0.03009478934109211,
-0.0053362175822257996,
0.03931301087141037,
-0.04951714351773262,
0.013531563803553581,
-0.013851982541382313,
-0.0217145849019289,
0.03438347950577736,
0.01885545626282692,
0.0010482956422492862,
0.026520878076553345,
-0.024142378941178322,
-0.021800851449370384,
-0.012730514630675316,
0.025263847783207893,
0.0033397574443370104,
-0.027087774127721786,
0.009458538144826889,
0.007030744105577469,
-0.011609045788645744,
0.00423015421256423,
0.01941002905368805,
-0.00884234718978405,
-0.026027925312519073,
-0.026471583172678947,
0.00334591930732131,
0.058562830090522766,
0.016476958990097046,
-0.04020032659173012,
0.008719108067452908,
-0.027087774127721786,
0.027284955605864525,
0.03773556277155876,
0.0005495657096616924,
0.021455785259604454,
-0.012348475866019726,
-0.01802976056933403,
-0.028862405568361282,
0.03194336220622063,
0.00076946901390329,
0.004778564441949129,
0.016526253893971443,
-0.009027204476296902,
0.03438347950577736,
0.018830809742212296,
-0.015651261433959007,
0.03884470835328102,
-0.012927696108818054,
0.013839659281075,
0.03354546055197716,
-0.005986299365758896,
0.04010173678398132,
-0.018337856978178024,
-0.022786758840084076,
0.033249687403440475,
0.012681218795478344,
-0.022022681310772896,
-0.0001345030323136598,
-0.026372991502285004,
0.010672435164451599,
-0.02350153960287571,
0.018535038456320763,
-0.0014927237061783671,
0.000555727630853653,
0.002916125813499093,
0.016797378659248352,
0.0015135201392695308,
-0.052105147391557693,
-0.043946772813797,
-0.042812980711460114,
-0.0277286134660244,
-0.0160086527466774,
0.007616125978529453,
-0.03721795976161957,
0.03418629989027977,
0.033865880221128464,
-0.009353785775601864,
-0.014283317141234875,
-0.03112998977303505,
0.02661946974694729,
-0.016131890937685966,
-0.019989250227808952,
0.01300163846462965,
-0.03987990692257881,
0.017660045996308327,
0.024807866662740707,
0.010493739508092403,
0.02039593644440174,
0.001833169488236308,
-0.024253293871879578,
0.02010016329586506,
-0.029355358332395554,
-0.006201966665685177,
-0.042615797370672226,
0.014061488211154938,
0.00013402162585407495,
0.017093149945139885,
0.00760996388271451,
0.006115699652582407,
-0.0277286134660244,
0.007788659539073706,
0.007190953940153122,
-0.014283317141234875,
-0.00029538676608353853,
-0.017216388136148453,
-0.05235162377357483,
-0.0069321533665061,
0.00980976689606905,
0.0023322845809161663,
-0.018966371193528175,
-0.03891864791512489,
0.03312645107507706,
0.0015774499624967575,
0.025066666305065155,
-0.005179089028388262,
-0.008065945468842983,
0.026323696598410606,
0.013309734873473644,
-0.0545206144452095,
-0.0030424450524151325,
-0.002033431548625231,
0.005456374958157539,
-0.03036591224372387,
-0.004276368301361799,
-0.017278006300330162,
0.010598491877317429,
-0.011800065636634827,
0.024019140750169754,
-0.031228581443428993,
-0.008934775367379189,
0.008281612768769264,
0.0038234677631407976,
0.01452979352325201,
-0.03472854942083359,
0.01483788900077343,
0.005179089028388262,
-0.019471649080514908,
0.018917076289653778,
0.016797378659248352,
0.01753680780529976,
-0.015651261433959007,
-0.010771025903522968,
0.020888889208436012,
-0.025953982025384903,
-0.022934643551707268,
-0.030538447201251984,
-0.004741592798382044,
0.0396580807864666,
-0.024807866662740707,
-0.051562897861003876,
0.01422169804573059,
0.027703965082764626,
0.0588093064725399,
0.0047261882573366165,
-0.02905958704650402,
0.01719173975288868,
0.01220059022307396,
0.01151045598089695,
-0.01216978020966053,
-0.003330514533445239,
0.0025679776445031166,
-0.02960183471441269,
-0.04917207360267639,
0.005077417008578777,
-0.027630023658275604,
-0.008324746042490005,
-0.00030694034649059176,
-0.03815457224845886,
-0.02059311605989933,
0.00490796472877264,
0.0005911586340516806,
0.00821383111178875,
-0.014862536452710629,
-0.027309603989124298,
-0.025781448930501938,
0.011769255623221397,
0.009267519228160381,
-0.048580531030893326,
0.00884234718978405,
-0.01651393063366413,
0.009033366106450558,
-0.007135496474802494,
-0.011559750884771347,
0.03100675158202648,
-0.0033798099029809237,
0.004257882479578257,
0.0066055720672011375,
0.0035893148742616177,
-0.000025803015887504444,
0.014579088427126408,
0.0026111111510545015,
-0.001745362184010446,
-0.024019140750169754,
-0.020839594304561615,
0.0023800393100827932,
0.02960183471441269,
0.042541854083538055,
-0.008891642093658447,
0.010949721559882164,
-0.023969845846295357,
0.05555581673979759,
0.04382353276014328,
-0.029158176854252815,
0.019360734149813652,
0.008823861368000507,
-0.0095756147056818,
-0.03320039436221123,
-0.01976742036640644,
-0.038992591202259064,
0.005314650945365429,
0.020013896748423576,
0.0026265159249305725,
0.09533713757991791,
0.0005973205552436411,
0.029700426384806633,
-0.018079055473208427,
0.0016498524928465486,
0.04547492787241936,
-0.0025695182848721743,
-0.0034537529572844505,
-0.041777778416872025,
0.011892493814229965,
-0.008411012589931488,
0.005049688741564751,
-0.008786889724433422,
-0.03645388409495354,
0.003937463276088238,
0.0202480498701334,
0.006728810258209705,
-0.015848442912101746,
0.0006901343585923314,
-0.019644182175397873,
0.027334250509738922,
0.0062574236653745174,
-0.0017284168861806393,
-0.011011340655386448,
-0.00953248143196106,
0.006494657602161169,
-0.019052637740969658,
-0.029996197670698166,
-0.01255181897431612,
-0.06743598729372025,
0.023390626534819603,
-0.011898656375706196,
0.016476958990097046,
-0.05442202463746071,
0.018707571551203728,
-0.010358178056776524,
-0.003567748237401247,
-0.04064398631453514,
0.0320173054933548,
0.06516840308904648,
0.006969125010073185,
0.013494592159986496,
-0.03440812975168228,
0.008423336781561375,
0.0027713209856301546,
-0.00736964913085103,
-0.016464633867144585,
0.017906522378325462,
0.00038242380833253264,
0.003327433718368411,
0.009329138323664665,
0.018843133002519608,
-0.03127787634730339,
-0.021936414763331413,
0.051907964050769806,
0.034777842462062836,
-0.054619207978248596,
0.03534473851323128,
-0.0015497213462367654,
0.02336597815155983,
0.0196195337921381,
-0.017647722736001015,
0.004932612180709839,
-0.02745748870074749,
-0.003804981941357255,
0.03337292745709419,
-0.03216519206762314,
-0.009162765927612782,
-0.023563159629702568,
0.003153359517455101,
0.022380072623491287,
-0.042393967509269714,
-0.02303323522210121,
-0.020580792799592018,
0.00020392084843479097,
0.021049099043011665,
0.029380006715655327,
-0.013297410681843758,
-0.01296466775238514,
-0.016945263370871544,
0.014135430566966534,
0.00943389069288969,
0.014924155548214912,
-0.010173319838941097,
-0.020679384469985962,
-0.005505670327693224,
0.024117732420563698,
0.015380137600004673,
-0.013272763229906559,
-0.02295929193496704,
-0.017019206658005714,
-0.01836250349879265,
-0.015035070478916168,
0.026644116267561913,
-0.03448207303881645,
0.027580726891756058,
-0.006679514888674021,
0.014887184835970402,
0.025830743834376335,
0.031228581443428993,
0.00004077454286743887,
0.003213438205420971,
0.011633694171905518,
-0.008423336781561375,
0.025337791070342064,
0.037686266005039215,
-0.007418944500386715,
-0.007998164743185043,
-0.02440118044614792,
0.01913890615105629,
0.0060355947352945805,
-0.013778040185570717,
0.002621894469484687,
-0.00860203243792057,
-0.013543887063860893,
0.0007340380107052624,
0.00926135666668415,
0.024327237159013748,
-0.00677810562774539,
-0.01685899682343006,
-0.002292232122272253,
0.03389052674174309,
-0.03472854942083359,
0.007184791844338179,
-0.01269354298710823,
-0.035665158182382584,
0.07369649410247803,
-0.0699007511138916,
-0.008250802755355835,
0.0035030480939894915,
0.005943166092038155,
-0.007554506883025169,
0.0072402493096888065,
0.03995385020971298,
-0.006161914207041264,
0.031869418919086456,
-0.0015119797317311168,
-0.007887249812483788,
0.0038419533520936966,
-0.014295640401542187,
-0.040323566645383835,
-0.01424634549766779,
-0.02114768885076046,
-0.01685899682343006,
-0.03280603140592575,
0.010031595826148987,
0.04702772945165634,
-0.0041223205626010895,
0.015860766172409058,
-0.014899508096277714,
0.07275988161563873,
-0.013580858707427979,
0.007708554621785879,
-0.022909997031092644,
0.013580858707427979,
-0.02844339609146118,
-0.026890592649579048,
-0.0008788430131971836,
0.001643690629862249,
-0.031450409442186356,
0.027235660701990128,
-0.007628449704498053,
-0.04500662162899971,
0.02661946974694729,
0.037760209292173386,
-0.01355621125549078,
0.018411800265312195,
-0.0006439200369641185,
0.0020457555074244738,
0.04759462550282478,
0.03209124878048897,
-0.013802687637507915,
-0.0034691577311605215,
-0.021332547068595886,
-0.010013110004365444,
-0.004137725103646517,
-0.017598425969481468,
0.007967354729771614,
-0.04335522651672363,
-0.05171078443527222,
0.0000396673203795217,
0.004994231276214123,
-0.040175680071115494,
-0.010586168617010117,
0.015441756695508957,
0.01473929826170206,
-0.004464306868612766,
-0.05111923813819885,
0.04564746096730232,
0.03376729041337967,
-0.011035988107323647,
0.014110783115029335,
0.006322124041616917,
-0.004495116416364908,
0.05486568436026573,
-0.03835175186395645,
0.023748017847537994,
0.007036905735731125,
-0.008269288577139378,
-0.03527079522609711,
0.027013830840587616,
0.018350180238485336,
-0.006913667544722557,
-0.0045628976076841354,
0.005431727506220341,
-0.016661815345287323,
0.04167918860912323,
0.02330435998737812,
0.005952409002929926,
-0.0032473288010805845,
-0.004057620652019978,
-0.016279777511954308,
-0.008793051354587078,
-0.006950639188289642,
0.01594703458249569,
0.0012785971630364656,
-0.017647722736001015,
0.007961193099617958,
-0.03849963843822479,
0.007117010653018951,
-0.004584464244544506,
-0.01614421419799328,
-0.01310022920370102,
-0.00523762684315443,
-0.01424634549766779,
0.015182956121861935,
0.0005095132510177791,
0.04005244001746178,
-0.05422484502196312,
-0.000028234082492417656,
-0.015564994886517525,
-0.018079055473208427,
0.013839659281075,
0.03778485581278801,
-0.026742707937955856,
0.014024516567587852,
-0.00039628808735869825,
0.0079796789214015,
0.015996329486370087,
0.010906588286161423,
-0.01782025583088398,
0.0170561783015728,
-0.016403015702962875,
0.019520943984389305,
-0.005373189225792885,
-0.006433038506656885,
-0.023686397820711136,
0.05353470891714096,
0.022971615195274353,
-0.009686528705060482,
-0.003373648039996624,
0.0013717961264774203,
0.017376597970724106,
-0.018337856978178024,
0.0023276631254702806,
-0.00835555512458086,
0.013223467394709587,
-0.01165217999368906,
0.018892427906394005,
-0.007973517291247845,
0.0028930187691003084,
0.004747754894196987,
0.022158242762088776,
-0.005829170811921358,
0.05057699233293533,
0.011732284910976887,
0.020371288061141968,
0.021196983754634857,
-0.022219862788915634,
-0.008805375546216965,
-0.0006778105744160712,
-0.005690527614206076,
0.0009789741598069668,
-0.06995005160570145,
-0.019742771983146667,
-0.010666273534297943,
0.003481481457129121,
-0.0349503755569458,
0.0206670593470335,
0.03147505596280098,
0.03529544547200203,
-0.018461095169186592,
0.033668696880340576,
0.008928613737225533,
-0.03502431884407997,
0.0068951817229390144,
0.010666273534297943,
0.011898656375706196,
0.034087710082530975,
-0.015762176364660263,
-0.02836945280432701,
0.019582562148571014,
-0.029380006715655327,
-0.04480943828821182,
0.006094133015722036,
0.06087971106171608,
0.03189406916499138,
0.016587872058153152,
-0.07029511779546738,
0.026865946128964424,
-0.004827859811484814,
-0.02994690276682377,
0.0196195337921381,
0.013309734873473644,
0.0018870861968025565,
0.03157364949584007,
0.005129793658852577,
-0.028887053951621056,
-0.0037495247088372707,
0.026175811886787415,
0.0314997062087059,
0.035886988043785095,
-0.03970737382769585,
-0.006771943531930447,
0.009156604297459126,
-0.006981448736041784,
-0.008651327341794968,
-0.008928613737225533,
0.005077417008578777,
0.01529387105256319,
0.06901343911886215,
-0.004020649008452892,
-0.0016098000342026353,
-0.02836945280432701,
0.03287997469305992,
-0.06206279993057251,
-0.022564928978681564,
-0.03043985553085804,
0.019508620724081993,
0.03413700312376022,
-0.003832710674032569,
-0.005514913238584995,
0.04986220970749855,
0.035048969089984894,
-0.02177620492875576,
-0.03246096521615982,
0.03825316205620766,
-0.03162294253706932,
0.020223401486873627,
-0.031376466155052185,
0.0244874469935894,
0.0409151092171669,
0.004867912270128727,
0.02378498762845993,
-0.007782497443258762,
-0.03320039436221123,
-0.027851851657032967,
-0.017364274710416794,
-0.03302786126732826,
-0.004698459524661303,
0.031228581443428993,
0.0005649704835377634,
-0.018670599907636642,
0.022762110456824303,
0.027013830840587616,
-0.03465460613369942,
0.025559619069099426,
-0.017992788925766945,
0.010616977699100971,
0.0026742706540971994,
0.007708554621785879,
0.01672343537211418,
-0.005034283734858036,
-0.020075516775250435,
-0.047249555587768555,
0.04547492787241936,
-0.011880170553922653,
0.05254880338907242,
0.030982105061411858,
-0.020420582965016365,
-0.0431087501347065,
-0.016661815345287323,
-0.01036433968693018,
0.062309276312589645,
-0.015109013766050339,
-0.014209373854100704,
0.004273287486284971,
0.007911897264420986,
0.01692061685025692,
0.02565821073949337,
0.027975089848041534,
0.028394099324941635,
-0.008158374577760696,
0.017364274710416794,
-0.028763815760612488,
0.030760275200009346,
0.005690527614206076,
-0.0011515077203512192,
-0.019015666097402573,
-0.020851917564868927,
0.009489348158240318,
0.018559684976935387,
0.0026111111510545015,
-0.027580726891756058,
0.007117010653018951,
-0.00814605038613081,
0.03154899924993515,
0.037563029676675797,
-0.0017777122557163239,
-0.011134578846395016,
-0.019656505435705185,
0.011935628019273281,
-0.028763815760612488,
0.027482137084007263,
-0.010006948374211788,
0.011473484337329865,
-0.009415404871106148,
0.0022306127939373255,
0.011461160145699978,
-0.015478728339076042,
0.005163684021681547,
0.013617830350995064,
-0.002409308450296521,
-0.0046953787095844746,
-0.023563159629702568,
0.0072402493096888065,
-0.03265814483165741,
-0.03795739263296127,
0.010074730031192303,
-0.015133661217987537,
-0.010586168617010117,
0.012903047725558281,
-0.016526253893971443,
0.0002227917138952762,
-0.03194336220622063,
0.0022983939852565527,
0.011233169585466385,
0.008873156271874905,
0.03349616378545761,
-0.01462838426232338,
-0.022145919501781464,
0.02844339609146118,
0.0039282203651964664,
-0.017290331423282623,
-0.05057699233293533,
0.03194336220622063,
-0.0038450344000011683,
-0.032411668449640274,
0.024179350584745407,
0.04362635314464569,
0.02363710291683674,
0.0074928877875208855,
0.02045755460858345,
-0.03066168539226055,
0.029922254383563995,
-0.008503441698849201,
0.011596722528338432,
0.001851655193604529,
0.015823794528841972,
0.004806293174624443,
0.0002308792172698304,
-0.04700307920575142,
-0.020716356113553047,
0.00334591930732131,
-0.002823697170242667,
0.005505670327693224,
-0.04158059507608414,
0.013346705585718155,
-0.02357548289000988,
0.010807997547090054,
-0.005129793658852577,
0.008404850959777832,
0.029848311096429825,
0.0066363816149532795,
-0.012681218795478344,
0.007918059825897217,
-0.027408193796873093,
-0.0035585053265094757,
-0.007702392525970936,
0.011849360540509224,
0.015577319078147411,
0.031918715685606,
0.011596722528338432,
-0.009236709214746952,
-0.00915044266730547,
-0.019508620724081993,
0.002190560568124056,
0.056541722267866135,
0.0070800394751131535,
0.016600197181105614,
0.037686266005039215,
0.018830809742212296,
-0.003034742781892419,
-0.00980976689606905,
0.0122683709487319,
-0.01851039007306099,
-0.002427794272080064,
-0.005456374958157539,
0.011344083584845066,
0.03189406916499138,
-0.020630087703466415,
-0.002691216068342328,
0.010592330247163773,
0.007961193099617958,
0.013186495751142502,
0.006587086245417595,
-0.000993608613498509,
-0.0016190429450944066,
0.0004952638410031796,
-0.025411734357476234,
0.009329138323664665,
0.005819927901029587,
0.005699770525097847,
0.057527631521224976,
0.005382432136684656,
-0.0012400852283462882,
0.04914742708206177,
0.004304097034037113,
-0.016205834224820137,
-0.010278073139488697,
0.001717633567750454,
-0.02592933550477028,
-0.015577319078147411,
0.0010136348428204656,
-0.007252573035657406,
-0.00467997370287776,
0.02059311605989933,
0.012058866210281849,
-0.01095588319003582,
0.009168928489089012,
0.005320813041180372,
-0.005678203888237476,
-0.033594757318496704,
0.006488495506346226,
0.01019180566072464,
-0.0006905195186845958,
0.026446934789419174,
-0.02738354541361332,
-0.012286856770515442,
0.04126017540693283,
0.0027158637531101704,
-0.004482792690396309,
0.03785879909992218,
0.023969845846295357,
0.047816455364227295,
0.007924221456050873,
-0.02565821073949337,
-0.010536872781813145,
0.02308253012597561,
-0.0715767964720726,
0.016822025179862976,
-0.015281546860933304,
-0.011319436132907867,
0.006771943531930447,
-0.014961127191781998,
-0.015047394670546055,
-0.013741068542003632,
0.012465552426874638,
0.011109931394457817,
0.03970737382769585,
0.0005588085623458028,
-0.0255842674523592,
0.00026438463828526437,
0.004840183537453413,
-0.005465617869049311,
-0.011109931394457817,
0.02510363794863224,
0.018498066812753677,
0.006152671296149492,
0.015712881460785866,
-0.02426561713218689,
-0.037464436143636703,
0.013605506159365177,
0.0029500164091587067,
-0.00966804288327694,
-0.018608979880809784,
0.001065240940079093,
0.026718059554696083,
0.0018300884403288364,
0.03093280829489231,
0.020198754966259003,
0.026890592649579048,
-0.020962832495570183,
-0.029996197670698166,
-0.015762176364660263,
-0.01753680780529976,
0.011849360540509224,
0.003567748237401247,
0.012853752821683884,
-0.006648705340921879,
0.0005784496897831559,
-0.03398911654949188,
0.007351163309067488,
-0.027432842180132866,
-0.005730580072849989,
0.0055857752449810505,
0.0042794495820999146,
-0.02585539221763611,
-0.00966804288327694,
-0.0023168798070400953,
0.039140477776527405,
-0.01085729245096445,
0.006457685958594084,
0.00624201912432909,
0.0007871845155023038,
-0.04786574840545654,
-0.014258669689297676,
-0.0035184528678655624,
0.026225106790661812,
0.009988462552428246,
0.0032350048422813416,
0.02933071181178093,
-0.022552605718374252,
0.03211589530110359,
0.019989250227808952,
0.007566830608993769,
-0.0020950508769601583,
-0.023242739960551262,
0.0022999343927949667,
-0.009963815100491047,
-0.028073681518435478,
0.0030008521862328053,
0.027063127607107162,
-0.01539246179163456,
-0.023563159629702568,
0.03337292745709419,
0.025806095451116562,
0.020087840035557747,
-0.006815076805651188,
0.001850114669650793,
-0.03822851553559303,
-0.009181251749396324,
0.006599409971386194,
0.0049233692698180676,
0.007554506883025169,
0.0021967224311083555,
0.019656505435705185,
-0.0022583415266126394,
-0.006882857996970415,
-0.0191512294113636,
-0.018251590430736542,
0.0031441166065633297,
-0.011177712120115757,
-0.017943494021892548,
-0.07162608951330185,
-0.016378367319703102,
0.0170561783015728,
-0.029034938663244247,
-0.012890724465250969,
-0.0030547690112143755,
-0.002247558208182454,
0.009735824540257454,
-0.03689754009246826,
-0.009094985201954842,
0.05042910575866699,
0.033323630690574646,
-0.02738354541361332,
0.0025186825077980757,
0.0007063093944452703,
0.01886778138577938,
-0.016883645206689835,
-0.02315647341310978,
-0.02940465323626995,
0.02363710291683674,
0.00919357594102621,
0.00662405788898468,
0.02994690276682377,
0.03209124878048897,
0.002945394953712821,
0.013149525038897991,
0.010031595826148987,
0.005262274760752916,
0.0388200581073761,
-0.031524352729320526,
-0.0028036709409207106,
0.020962832495570183,
0.003595476970076561,
-0.021406490355730057,
-0.002013405552133918,
0.008934775367379189,
0.0031980334315449,
0.03337292745709419,
0.026594821363687515,
0.0370454266667366,
-0.019952278584241867,
-0.018535038456320763,
0.04453831538558006,
0.04557351768016815,
-0.023550836369395256,
0.01424634549766779,
0.00589387072250247,
-0.02918282523751259,
-0.04956643655896187,
0.0001960258960025385,
-0.004180858843028545,
-0.00535778421908617,
-0.013137200847268105,
0.014677679166197777,
0.001346378237940371,
0.040397509932518005,
-0.004011406097561121,
-0.0017961979610845447,
-0.001004392048344016,
0.001228531589731574,
-0.018596656620502472,
0.0034722385462373495,
0.004411930684000254,
-0.010524549521505833,
-0.01767236925661564,
0.0005087430472485721,
-0.02427794225513935,
-0.028172271326184273,
0.05984450876712799,
0.02419167570769787,
-0.011066798120737076,
0.010327368043363094,
-0.022293806076049805,
-0.022158242762088776,
0.039830613881349564,
-0.03951019421219826,
0.009212061762809753,
-0.010296558029949665,
-0.02523919939994812,
-0.01746286451816559,
0.013888954184949398,
-0.0006400688434951007,
-0.015355490148067474,
-0.056196656078100204,
-0.017573779448866844,
0.0315982960164547,
0.00396827282384038,
-0.014209373854100704,
0.003925139084458351,
-0.005647394340485334,
0.01567590981721878,
-0.03085886500775814,
-0.0079796789214015,
-0.01307558175176382,
0.015860766172409058,
-0.008059783838689327,
-0.009785119444131851,
-0.010241101495921612,
-0.0019764339085668325,
0.0005303097423166037,
-0.018042083829641342,
0.021998032927513123,
0.015022746287286282,
-0.03253490477800369,
0.02496807649731636,
-0.01970580220222473,
-0.018707571551203728,
0.01996460184454918,
0.013371353968977928,
-0.04138341546058655,
0.013469944708049297,
-0.004994231276214123,
0.006698000710457563,
0.004633759614080191,
-0.007400458678603172,
-0.0019055719021707773,
0.00313795474357903,
-0.010586168617010117,
0.048777710646390915,
-0.0005268436507321894,
0.004211668390780687,
0.03598557785153389,
-0.019249819219112396,
0.0042886920273303986,
0.009926843456923962,
0.02703847922384739,
-0.014998098835349083,
-0.01133792195469141,
-0.03258420154452324,
-0.04096440598368645,
0.0032504096161574125,
-0.021998032927513123,
0.01816532202064991,
0.02406843565404415,
0.010241101495921612,
-0.01424634549766779,
-0.0004887168179266155,
-0.04249256104230881,
0.009458538144826889,
-0.004202425479888916,
-0.03509826213121414,
0.008183022029697895,
-0.0017438216600567102,
-0.02696453593671322,
-0.020962832495570183,
0.022071976214647293,
0.01196027547121048,
0.004113077651709318,
-0.006229695398360491,
-0.008762242272496223,
0.02128325216472149,
-0.034629955887794495,
-0.006238937843590975,
0.0260032769292593,
-0.0038604391738772392,
-0.000175903391209431,
0.03529544547200203,
0.00008665191853651777,
-0.016476958990097046,
0.013198819942772388,
0.037760209292173386,
-0.021455785259604454,
-0.014418878592550755,
-0.02795044332742691,
-0.0033212716225534678,
-0.013396001420915127,
0.010894264094531536,
0.10430888086557388,
-0.01664949208498001,
0.005240708123892546,
-0.0025340872816741467,
0.012539494782686234,
-0.024462798610329628,
0.027580726891756058,
-0.007104686927050352,
0.019508620724081993,
0.005736742168664932,
-0.0014711569529026747,
0.0006789659382775426,
0.011966437101364136,
0.04485873505473137,
-0.001004392048344016,
-0.02183782309293747,
-0.0198290403932333,
0.0011468862649053335,
-0.005724418442696333,
-0.024844838306307793,
0.0024647656828165054,
0.016822025179862976,
-0.028270861133933067,
0.034284889698028564,
-0.01941002905368805,
-0.001702228793874383,
-0.014431202784180641,
-0.007338839583098888,
0.008891642093658447,
0.004011406097561121,
0.030612388625741005,
-0.023883579298853874,
0.047816455364227295,
-0.038869354873895645,
0.011572075076401234,
-0.03379193693399429,
-0.009070337750017643,
-0.026520878076553345,
0.00299006886780262,
0.02198570966720581,
0.009316814132034779,
-0.008121402934193611,
0.016871320083737373,
0.03231307864189148,
0.00677810562774539,
0.017117798328399658,
-0.023045558482408524,
-0.0008780727512203157,
0.0063837431371212006,
-0.007135496474802494,
-0.02711242251098156,
-0.003894329769536853,
0.004436578135937452,
-0.002164372242987156,
-0.04180242493748665,
-0.048235464841127396,
0.005283841397613287,
-0.01178774144500494,
0.015959357842803,
-0.034629955887794495,
-0.0017053097253665328,
0.038179218769073486,
0.038795411586761475,
0.010358178056776524,
0.01740124635398388
] | 2025-01-14 | 33 | 39805660 | [
"effector T cells",
"CD93 blockade",
"administered effector T cells",
"CD93",
"pmel-1 transgenic T cells",
"CAR)-T cell therapy",
"tumor vascular maturation",
"tumor vascular functions",
"tumor vasculature",
"immune checkpoint blockade therapy",
"improved effector T-cell infiltration",
"tumors",
"inhibit tumor progression",
"effector T-cell infiltration",
"blockade",
"implanted mouse melanoma models",
"solid cancers",
"vascular maturation",
"adhesion molecules",
"Adaptive cellular therapy",
"a solid mouse tumor model",
"pre-activated CD8+OT-1",
"ACT",
"mechanistic studies",
"CAR-T cells",
"T-cell transfer",
"the CD93 pathway",
"tumor-infiltrating T lymphocytes",
"function",
"CAR-T therapy"
] | [
"Adoptive cell therapy - ACT",
"Immunotherapy",
"Solid tumor",
"T cell",
"Tumor infiltrating lymphocyte - TIL"
] | 0 | 10.1136/jitc-2024-010554
10.1126/science.aaa4967
10.1126/science.aar6711
10.1016/j.molimm.2014.09.017
10.1158/1535-7163.MCT-23-0310
10.1056/NEJMoa1103849
10.1056/NEJMoa1707447
10.1056/NEJMoa2210233
10.1200/JCO.21.00612
10.1007/s40291-024-00749-3
10.1158/0008-5472.CAN-12-4354
10.1158/1078-0432.CCR-18-2722
10.1016/j.biopha.2024.117080
10.1200/JCO.21.02170
10.1158/2159-8290.CD-23-1334
10.1016/j.jcyt.2023.01.009
10.1200/EDBK_180328
10.1101/cshperspect.a041170
10.1016/j.cca.2023.117487
10.1111/imm.12380
10.1158/0008-5472.CAN-14-2598
10.1016/j.coi.2015.01.011
10.1016/j.trecan.2017.10.002
10.1126/scitranslmed.abc8922
10.4049/jimmunol.0902995
10.1016/s1074-7613(00)80023-0
10.1084/jem.20030590
10.1038/s41416-020-01048-4
10.1093/annonc/mdx238
10.1084/jem.186.2.239
10.1038/315115a0
10.1182/blood-2010-01-265041
10.1038/nature21724
10.1016/j.matbio.2017.08.003 | [
"Sun",
"Yee",
"Fujiwara",
"Dickinson",
"Guo",
"Sun",
"Hu",
"Davila",
"Schulick",
"Zhu"
] | [
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.",
"Division of Surgical Oncology, Department of Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA [email protected]."
] | [
"39805660",
"25838374",
"29567707",
"25451975",
"37903371",
"21830940",
"29226797",
"36477031",
"33979178",
"39404764",
"23440426",
"30518633",
"38972151",
"35104158",
"38563600",
"36775787",
"28561728",
"35193894",
"37442359",
"25196648",
"25344227",
"25665467",
"29198436",
"34321321",
"20237297",
"10072075",
"12925674",
"32929195",
"29045511",
"9221753",
"8521395",
"20631379",
"8640769"
] | [] | 9.682021 | 5.138822 |
39805063 | 37 | Chimeric Antigen Receptor-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy. | Colorectal cancer (CRC) remains a major global health burden, being one of the most prevalent cancers with high mortality rates. Despite advances in conventional treatment modalities, patients with metastatic CRC often face limited options and poor outcomes. Chimeric antigen receptor-T (CAR-T) cell therapy, initially successful in hematologic malignancies, presents a promising avenue for treating solid tumors, including CRC. This review explores the potential of CAR-T cell therapy in CRC by analyzing clinical trials and highlighting prominent CRC-specific targets. We discuss the challenges such as immunosuppressive microenvironment, tumor heterogeneity, and physical barriers that limit CAR-T efficacy. Emerging strategies, such as logic-gated and dual-targeting CAR-T cells, offer practical solutions to overcome these hurdles. Furthermore, we explore the combination of CAR-T cell therapy with immune checkpoint inhibitors to enhance T-cell persistence and tumor infiltration. As the field continues to evolve, CAR-T cell therapies hold significant potential for revolutionizing the treatment landscape of CRC. | [
0.03733886405825615,
0.04013817757368088,
0.08164294809103012,
0.0665222555398941,
-0.03998388350009918,
-0.005422290880233049,
0.0274420827627182,
0.035090599209070206,
0.008678971789777279,
0.0353550985455513,
-0.02118220180273056,
-0.027640458196401596,
-0.028411922976374626,
0.028059253469109535,
0.030417729169130325,
-0.048095278441905975,
0.05215097591280937,
-0.014470463618636131,
0.03581797704100609,
0.046508267521858215,
0.012596908025443554,
-0.00827119778841734,
0.003744356334209442,
-0.0036424128338694572,
-0.04137251898646355,
0.006662143860012293,
0.004149375017732382,
0.012310364283621311,
-0.0313214436173439,
-0.02398151531815529,
0.005229424685239792,
-0.02631794847548008,
-0.06564057618379593,
-0.03251170367002487,
-0.008116904646158218,
0.037140488624572754,
0.02748616598546505,
0.028786635026335716,
-0.042562779039144516,
0.006160692311823368,
0.03725069761276245,
0.01683996059000492,
0.01566072180867195,
0.08058494329452515,
-0.048403866589069366,
-0.021512828767299652,
0.004311933647841215,
-0.05303265154361725,
0.0034770991187542677,
-0.017787760123610497,
-0.03758132457733154,
0.015021509490907192,
-0.004424897953867912,
0.018140427768230438,
-0.04254073649644852,
0.028522131964564323,
-0.05607442185282707,
0.010469870641827583,
-0.0012460523284971714,
0.026538366451859474,
0.0028902352787554264,
-0.013125911355018616,
0.006739290431141853,
-0.03811033070087433,
-0.07256171107292175,
-0.023430468514561653,
-0.028345797210931778,
-0.022107958793640137,
0.006910114549100399,
0.0024686853867024183,
0.014382296241819859,
-0.007620963733643293,
0.02123730629682541,
0.020906679332256317,
0.0708865374326706,
-0.028103336691856384,
0.005617912393063307,
0.02986668422818184,
0.012938556261360645,
-0.020895658060908318,
0.01922047883272171,
-0.029161345213651657,
0.011781360022723675,
-0.04051288962364197,
0.00685501005500555,
-0.0019438142189756036,
0.01810736581683159,
-0.03861729055643082,
-0.04203377664089203,
0.012409552000463009,
-0.0012377867242321372,
-0.012718137353658676,
-0.04057901352643967,
0.03584001958370209,
0.005430556833744049,
0.021292410790920258,
-0.01644320785999298,
-0.02907317876815796,
0.036677610129117966,
0.02400355599820614,
0.05999787151813507,
0.028433965519070625,
-0.01611258089542389,
-0.025392191484570503,
0.056735679507255554,
-0.00047906546387821436,
-0.05294448509812355,
-0.03489222005009651,
0.028456006199121475,
-0.005389227997511625,
0.04007205367088318,
-0.014062689617276192,
-0.02283533848822117,
0.01961723156273365,
-0.024201933294534683,
-0.04977045953273773,
-0.009940866380929947,
-0.00021198044123593718,
-0.00801771692931652,
0.03621473163366318,
-0.016233809292316437,
0.0314096137881279,
0.02548035979270935,
-0.03804420307278633,
0.022901464253664017,
-0.024069681763648987,
0.031145110726356506,
-0.025810986757278442,
-0.02283533848822117,
-0.052856314927339554,
0.01100438553839922,
0.018173491582274437,
0.02075238525867462,
-0.002428734442219138,
-0.08287729322910309,
-0.004295402206480503,
-0.013181015849113464,
0.0014699148014187813,
-0.016366060823202133,
-0.015098655596375465,
-0.002215204294770956,
-0.026207739487290382,
-0.01927558332681656,
-0.015781952068209648,
-0.013985543511807919,
-0.052812233567237854,
-0.01846003532409668,
0.04485512897372246,
-0.006089056376367807,
0.043179951608181,
-0.01999194175004959,
0.040556974709033966,
0.0706661194562912,
-0.009874741546809673,
-0.025744860991835594,
-0.025259939953684807,
0.008937963284552097,
0.060703206807374954,
-0.024113764986395836,
-0.042188066989183426,
-0.025370150804519653,
0.00983065739274025,
-0.031960658729076385,
-0.025392191484570503,
0.03661148622632027,
-0.032401494681835175,
-0.03617064654827118,
0.0312994047999382,
-0.04397345706820488,
-0.01058007963001728,
-0.027574332430958748,
-0.07031344622373581,
-0.06824151426553726,
-0.02004704810678959,
-0.035465311259031296,
-0.010739883407950401,
0.02426805905997753,
0.022515732795000076,
-0.005951295141130686,
0.013831250369548798,
-0.0034633229952305555,
0.026604492217302322,
0.016740772873163223,
0.0034605679102241993,
0.001960345543920994,
0.014239024370908737,
0.009207976050674915,
0.006160692311823368,
-0.05611850693821907,
-0.020509926602244377,
0.00309136719442904,
0.0029453400056809187,
0.040556974709033966,
0.013280204497277737,
-0.021071992814540863,
0.0014602714218199253,
0.04437021166086197,
0.02276921458542347,
-0.028411922976374626,
-0.013037743978202343,
0.02426805905997753,
-0.023474551737308502,
-0.028852758929133415,
-0.005273508373647928,
-0.01926456205546856,
-0.03969734162092209,
-0.015605618245899677,
0.05312081798911095,
-0.02437826804816723,
0.013544706627726555,
0.03423096612095833,
0.011329501867294312,
-0.01720365136861801,
0.01682893931865692,
-0.005626177880913019,
-0.030770398676395416,
-0.014911300502717495,
0.0509166345000267,
0.038286663591861725,
0.03416484221816063,
0.018989039584994316,
0.009698406793177128,
0.011428690515458584,
-0.007846892811357975,
-0.017523257061839104,
-0.00043704823474399745,
0.02389334701001644,
-0.004785832948982716,
0.011505836620926857,
-0.023011673241853714,
0.005485661327838898,
0.010894175618886948,
0.01928660459816456,
-0.004995230585336685,
-0.033128876239061356,
-0.04562659561634064,
0.009714937768876553,
-0.018349826335906982,
0.04756627604365349,
-0.012596908025443554,
0.022967590019106865,
0.02867642417550087,
0.03780174255371094,
-0.05523683503270149,
-0.028522131964564323,
0.0012605172814801335,
-0.024444393813610077,
-0.06396540254354477,
0.014690881595015526,
0.011869527399539948,
-0.005890680011361837,
0.046111516654491425,
0.023033715784549713,
0.005110950209200382,
0.02827967144548893,
0.012817326001822948,
0.03024139441549778,
-0.05219506099820137,
0.026472242549061775,
-0.03370196372270584,
-0.003499140962958336,
-0.013147953897714615,
-0.03387829661369324,
-0.07300255447626114,
-0.04119618609547615,
0.026428157463669777,
-0.004733483772724867,
-0.012089945375919342,
0.02594323828816414,
-0.02477502077817917,
0.059424784034490585,
-0.00264364224858582,
0.02861030027270317,
-0.0078579131513834,
-0.04875653609633446,
-0.008800202049314976,
-0.007097470108419657,
0.013952480629086494,
0.01200177799910307,
0.004292646888643503,
-0.01809634454548359,
0.005802512634545565,
0.02622978202998638,
-0.04163702204823494,
0.012784263119101524,
-0.03339337557554245,
0.005846596322953701,
0.005824554245918989,
0.00154292827937752,
-0.03409871459007263,
0.020917698740959167,
-0.0012756710639223456,
-0.02124832756817341,
0.0054746405221521854,
-0.019110269844532013,
-0.018195534124970436,
-0.0034688333980739117,
-0.016784856095910072,
-0.02152385003864765,
0.02318800799548626,
-0.03301866725087166,
0.014459442347288132,
-0.016685668379068375,
-0.021909581497311592,
0.032004740089178085,
-0.010271494276821613,
0.0023336790036410093,
-0.03885975107550621,
0.02318800799548626,
0.06303964555263519,
-0.012618949636816978,
-0.039014045149087906,
0.05148972198367119,
0.0392565056681633,
0.016641583293676376,
0.002738697687163949,
0.03857320919632912,
-0.03978550806641579,
-0.004482757765799761,
-0.024069681763648987,
-0.032754164189100266,
-0.0045902119018137455,
-0.020256444811820984,
0.029624223709106445,
-0.0014037892688065767,
-0.05215097591280937,
-0.00003403138543944806,
-0.008778160437941551,
0.04386324808001518,
-0.03976346552371979,
-0.004862979520112276,
-0.06480298936367035,
0.05259181559085846,
-0.03892587870359421,
0.004948391579091549,
-0.032313328236341476,
-0.026141613721847534,
-0.06383314728736877,
0.050828468054533005,
-0.011461753398180008,
0.050079043954610825,
0.030726315453648567,
-0.01761142536997795,
0.05735284835100174,
-0.025215856730937958,
-0.029690349474549294,
0.003193310694769025,
0.00807282142341137,
0.01255282387137413,
0.01768857054412365,
0.009466967545449734,
0.008116904646158218,
0.01139562763273716,
0.018537182360887527,
0.0024865942541509867,
0.027177579700946808,
-0.03288641571998596,
-0.029910767450928688,
0.01236546877771616,
-0.006287432741373777,
0.012387510389089584,
0.022240210324525833,
-0.0666104182600975,
0.04174723103642464,
0.04897695407271385,
0.05188647657632828,
-0.04977045953273773,
0.003926201723515987,
-0.0051054395735263824,
-0.04862428456544876,
0.0039399778470396996,
0.0007507999544031918,
0.013798187486827374,
-0.008458553813397884,
-0.006425194442272186,
0.003041772870346904,
0.02309984154999256,
0.01492232084274292,
0.008359365165233612,
-0.004587456583976746,
0.010938259772956371,
0.00046907775686122477,
0.00046528931125067174,
-0.024995438754558563,
-0.0215679332613945,
0.018757600337266922,
0.004099781159311533,
-0.006309474818408489,
-0.07335522025823593,
0.005557297263294458,
-0.0021490787621587515,
0.0058080232702195644,
0.014084731228649616,
-0.018151449039578438,
0.002337811980396509,
0.06242247298359871,
-0.03370196372270584,
0.08076127618551254,
0.03967529907822609,
0.0038352790288627148,
0.008243645541369915,
-0.03687598556280136,
0.00176610192283988,
-0.020179297775030136,
0.006331516429781914,
-0.02006908878684044,
0.03264395520091057,
0.00022386237105820328,
0.03617064654827118,
-0.009207976050674915,
-0.009566155262291431,
0.015451325103640556,
0.03370196372270584,
0.032732121646404266,
-0.01693914830684662,
-0.04227623715996742,
-0.04042472317814827,
0.03286437317728996,
-0.020675240084528923,
-0.0016310956561937928,
0.07022528350353241,
-0.006281922571361065,
0.01512069720774889,
0.0032787227537482977,
-0.00018081191228702664,
0.031189193949103355,
0.0313434861600399,
0.006799905560910702,
-0.01022741012275219,
-0.046111516654491425,
-0.04154885560274124,
0.043179951608181,
0.01729181781411171,
-0.016366060823202133,
0.007444628980010748,
0.058278605341911316,
-0.0030610596295446157,
0.03811033070087433,
-0.030792441219091415,
-0.009593707509338856,
-0.05034354701638222,
0.006540914066135883,
0.014205961488187313,
-0.013853291980922222,
0.04509758949279785,
0.005598625633865595,
0.04196764901280403,
0.062202055007219315,
-0.0353771410882473,
-0.023739054799079895,
0.0255024004727602,
-0.028411922976374626,
-0.021391598507761955,
0.005579338874667883,
-0.03736090660095215,
-0.012420573271811008,
0.032004740089178085,
-0.08071719110012054,
-0.007714641746133566,
0.03379013016819954,
0.0353330597281456,
-0.028852758929133415,
0.019396813586354256,
-0.03379013016819954,
0.0026119572576135397,
0.034804053604602814,
0.03885975107550621,
0.0012853144435212016,
0.005507702939212322,
-0.027574332430958748,
0.02750820852816105,
0.02704533003270626,
-0.019132310524582863,
0.01769959181547165,
-0.009108787402510643,
0.03861729055643082,
0.0010325220646336675,
-0.0022579103242605925,
-0.011913610622286797,
0.008486106060445309,
-0.016630563884973526,
0.00035008630948141217,
-0.0009484876063652337,
-0.006766842678189278,
0.007218700367957354,
0.002087085973471403,
-0.05069621652364731,
0.02466481178998947,
-0.017402026802301407,
0.03299662470817566,
-0.0037994610611349344,
-0.0057694497518241405,
-0.003824257990345359,
-0.008034247905015945,
-0.026560408994555473,
-0.014657818712294102,
-0.0013686601305380464,
-0.015815015882253647,
-0.038727499544620514,
-0.0029315638821572065,
-0.00826568715274334,
-0.01471292320638895,
0.01256384514272213,
-0.01886780932545662,
0.029646266251802444,
0.05175422504544258,
0.03460567817091942,
0.06806518137454987,
0.039521005004644394,
0.020201340317726135,
-0.05651526153087616,
-0.0035680218134075403,
0.04046880453824997,
0.0033531137742102146,
-0.03639106824994087,
-0.009307163767516613,
-0.05448741093277931,
-0.024201933294534683,
-0.009048172272741795,
-0.009698406793177128,
-0.0018336049979552627,
-0.023694971576333046,
0.013621852733194828,
-0.0009643302182666957,
0.01884576678276062,
-0.016299935057759285,
-0.04403958097100258,
-0.02389334701001644,
-0.024201933294534683,
-0.026846952736377716,
0.003165758214890957,
-0.01726977713406086,
-0.014591693878173828,
0.03213699162006378,
-0.02113811857998371,
-0.013324287720024586,
-0.021435683593153954,
0.01962825283408165,
-0.026406116783618927,
-0.050784382969141006,
0.002986668376252055,
-0.02902909368276596,
0.002870948752388358,
0.009731469675898552,
-0.0022482669446617365,
0.04981454461812973,
-0.004650826565921307,
-0.015241927467286587,
0.03504651412367821,
-0.009296143427491188,
0.03271007910370827,
-0.055942174047231674,
0.0042375423945486546,
0.0055710733868181705,
0.03094673343002796,
-0.03504651412367821,
-0.01119174063205719,
-0.031960658729076385,
-0.02281329780817032,
-0.02276921458542347,
-0.010271494276821613,
-0.010343129746615887,
0.008105884306132793,
-0.02112709730863571,
-0.0029205428436398506,
0.020554009824991226,
-0.005449843127280474,
-0.025370150804519653,
-0.028169462457299232,
0.016233809292316437,
-0.0009202465298585594,
-0.0195731483399868,
0.006127629429101944,
-0.014283107593655586,
0.04672868549823761,
0.0024769511073827744,
-0.013081828132271767,
0.0070699178613722324,
0.01683996059000492,
0.016586478799581528,
-0.0314316526055336,
-0.01920945756137371,
0.013247141614556313,
0.04553842917084694,
-0.009571665897965431,
0.026450200006365776,
-0.0274200402200222,
-0.024135807529091835,
-0.01648729108273983,
-0.003747111652046442,
0.04159294068813324,
0.02075238525867462,
0.042166028171777725,
0.01803021878004074,
-0.034759972244501114,
0.016718730330467224,
-0.0003519805322866887,
0.005380962509661913,
-0.01528601162135601,
0.014283107593655586,
0.0022813298273831606,
0.017104461789131165,
0.0004921528161503375,
-0.05267998203635216,
-0.027177579700946808,
0.026935121044516563,
-0.0014230759115889668,
-0.038661375641822815,
0.01731386035680771,
0.00774219399318099,
0.02940380573272705,
0.03859524801373482,
-0.04035859555006027,
0.01078947726637125,
0.039895717054605484,
0.006370089948177338,
-0.03101285919547081,
-0.020234402269124985,
0.010960301384329796,
-0.011538899503648281,
-0.006513361819088459,
-0.011340523138642311,
-0.011560941115021706,
-0.0097920848056674,
-0.022118980064988136,
-0.04342241212725639,
-0.02708941325545311,
0.0014520058175548911,
0.021105054765939713,
0.003512917086482048,
0.030770398676395416,
-0.04941779002547264,
-0.023386385291814804,
0.04342241212725639,
-0.008116904646158218,
-0.0353110171854496,
0.025414234027266502,
-0.003920691087841988,
-0.009973929263651371,
-0.0022785745095461607,
-0.016663625836372375,
0.01646524854004383,
-0.017468152567744255,
-0.016189726069569588,
-0.0013624607818201184,
0.008800202049314976,
-0.008155478164553642,
-0.01732488162815571,
-0.014812111854553223,
-0.012244238518178463,
-0.0002991145593114197,
-0.027375956997275352,
0.01732488162815571,
-0.05184239149093628,
0.0021339249797165394,
0.005430556833744049,
0.021314453333616257,
0.02907317876815796,
0.058675359934568405,
0.06211388483643532,
-0.02790496125817299,
0.022262251004576683,
-0.0314096137881279,
-0.009059193544089794,
-0.020223380997776985,
-0.004664603155106306,
0.013489602133631706,
-0.007549327798187733,
-0.004559904336929321,
-0.021777331829071045,
0.07586798816919327,
0.019484980031847954,
0.010679268278181553,
-0.018691474571824074,
-0.005664750933647156,
0.013081828132271767,
0.02429009974002838,
-0.006755821872502565,
-0.01058007963001728,
0.013258162885904312,
-0.02636203169822693,
0.025678735226392746,
-0.03207086771726608,
-0.04247461259365082,
-0.004738993942737579,
-0.012652012519538403,
0.021832436323165894,
0.021027909591794014,
0.007224211003631353,
-0.0058521064929664135,
0.00766504742205143,
-0.02074136584997177,
-0.027640458196401596,
0.022901464253664017,
0.002638131845742464,
0.0391683392226696,
0.014448422007262707,
-0.015936246141791344,
-0.008849795907735825,
-0.03764745220541954,
0.05373799055814743,
0.023739054799079895,
0.019881732761859894,
-0.026538366451859474,
0.03800012171268463,
-0.027177579700946808,
0.006083545740693808,
-0.018261658027768135,
0.011781360022723675,
0.019044144079089165,
0.0236068032681942,
0.006618060637265444,
-0.0255024004727602,
-0.0054718852043151855,
-0.02231735549867153,
0.01296059787273407,
-0.010850092396140099,
0.030285479500889778,
0.004168661776930094,
0.03372400626540184,
0.010927238501608372,
0.00597333675250411,
0.003421994624659419,
0.01680689863860607,
0.029249513521790504,
0.033195000141859055,
-0.026758786290884018,
0.03612656518816948,
-0.01607951708137989,
0.014459442347288132,
-0.003157492494210601,
-0.049285538494586945,
-0.016553416848182678,
-0.011147657409310341,
-0.02594323828816414,
0.023077799007296562,
-0.012497719377279282,
-0.038639333099126816,
0.02708941325545311,
0.01769959181547165,
0.023232093080878258,
-0.01887883059680462,
-0.03599431365728378,
-0.027375956997275352,
-0.022306334227323532,
0.03680986166000366,
0.008971026167273521,
0.007913017645478249,
0.013941459357738495,
-0.028037210926413536,
0.01472394447773695,
0.006188244558870792,
-0.011825443245470524,
-0.02199774980545044,
0.021336494013667107,
-0.026891035959124565,
-0.0009567533270455897,
0.004165906459093094,
-0.04152681306004524,
-0.0009615749586373568,
-0.02082953229546547,
0.017842864617705345,
0.025348108261823654,
-0.0037002726458013058,
-0.001435474376194179,
0.043730996549129486,
0.024598686024546623,
0.008166499435901642,
-0.02080748975276947,
0.01566072180867195,
-0.0069046043790876865,
-0.030924692749977112,
0.003926201723515987,
-0.00822711456567049,
-0.01569378562271595,
0.01760040409862995,
-0.025215856730937958,
0.014867216348648071,
-0.02468685247004032,
0.013853291980922222,
0.01291651464998722,
-0.0088167330250144,
-0.014944362454116344,
0.0196833573281765,
0.012993660755455494,
-0.007372993044555187,
-0.006397642195224762,
0.03015322797000408,
-0.0008231247193180025,
-0.011307460255920887,
-0.012839367613196373,
0.01569378562271595,
-0.0176334660500288,
0.015759911388158798,
-0.01528601162135601,
0.04624376446008682,
0.02592119574546814,
-0.07035753130912781,
-0.019540084525942802,
-0.0051385024562478065,
0.007356461603194475,
-0.002195917535573244,
0.008436511270701885,
-0.02585506998002529,
-0.012707117013633251,
-0.005565562751144171,
-0.026185696944594383,
0.00998495053499937,
-0.031101027503609657,
0.00782485119998455,
0.023739054799079895,
-0.006596018560230732,
-0.008188541047275066,
-0.018206553533673286,
-0.07097470015287399,
0.004722462967038155,
0.024025598540902138,
0.007361972238868475,
0.019473958760499954,
0.003521182807162404,
0.07128328830003738,
-0.008006695657968521,
0.024113764986395836,
-0.023474551737308502,
-0.02629590779542923,
-0.0314536951482296,
-0.028081296011805534,
0.009566155262291431,
0.03348154574632645,
-0.01043680775910616,
0.04190152511000633,
-0.012541803531348705,
-0.059116195887327194,
0.009114298038184643,
-0.03418688476085663,
0.004918084014207125,
0.006193755194544792,
-0.008480595424771309,
0.0015980328898876905,
0.04395141452550888,
0.01159400399774313,
-0.018195534124970436,
-0.024532560259103775,
-0.03297458216547966,
-0.002525167539715767,
0.002428734442219138,
-0.024069681763648987,
0.011439711786806583,
-0.03259987011551857,
-0.025392191484570503,
-0.027001244947314262,
-0.004028145223855972,
-0.01729181781411171,
0.014139835722744465,
0.029205428436398506,
0.02047686278820038,
-0.013732061721384525,
-0.026868995279073715,
0.03464976325631142,
0.03222516179084778,
0.020554009824991226,
-0.01643218658864498,
-0.008750608190894127,
-0.04113006219267845,
0.01099336426705122,
-0.025987321510910988,
-0.0011682171607390046,
0.014812111854553223,
-0.011935652233660221,
-0.033900339156389236,
0.04031451418995857,
-0.0035928187426179647,
0.004482757765799761,
-0.0003221896186005324,
0.005254222080111504,
0.0021559668239206076,
0.0068715414963662624,
-0.03211494907736778,
-0.02633999101817608,
0.004066718276590109,
-0.005166054703295231,
-0.02788291871547699,
-0.019319666549563408,
-0.017765717580914497,
0.03383421525359154,
0.009863720275461674,
-0.030461814254522324,
0.0028351307846605778,
-0.011257866397500038,
0.0061221192590892315,
-0.006965219508856535,
-0.014823133125901222,
-0.03180636465549469,
0.00842549093067646,
-0.006441725883632898,
0.013831250369548798,
-0.005000740755349398,
0.02431214228272438,
-0.03189453110098839,
-0.009329206310212612,
-0.026891035959124565,
-0.0038022161461412907,
-0.030439771711826324,
0.047654442489147186,
0.01919843629002571,
0.014216982759535313,
-0.019804587587714195,
-0.0029288085643202066,
-0.009863720275461674,
0.04238644614815712,
-0.015616638585925102,
0.026494283229112625,
-0.0018019198905676603,
0.01891189254820347,
-0.02119322307407856,
0.011318481527268887,
-0.001200591097585857,
0.07264988124370575,
0.008943473920226097,
0.008116904646158218,
-0.032423537224531174,
-0.015969308093190193,
-0.0057694497518241405,
0.008105884306132793,
0.023033715784549713,
0.028037210926413536,
-0.0020292261615395546,
0.026185696944594383,
0.00577496038749814,
0.0235186368227005,
0.03299662470817566,
0.007042365614324808,
0.04033655300736427,
0.04397345706820488,
0.03301866725087166,
-0.0013459294568747282,
0.02667061798274517,
-0.015969308093190193,
-0.0027221664786338806,
0.0012777375523000956,
-0.024951355531811714,
0.050519879907369614,
-0.022284293547272682,
-0.04267298802733421,
0.0030197312589734793,
0.00589619018137455,
-0.001998918829485774,
-0.03019731119275093,
0.011307460255920887,
0.031189193949103355,
0.04985862597823143,
0.016740772873163223,
0.02940380573272705,
0.017831843346357346,
-0.005549031309783459,
-0.01119725126773119,
-0.003275967435911298,
-0.024223973974585533,
0.0509607195854187,
-0.023232093080878258,
-0.03323908522725105,
0.004763791337609291,
-0.018360847607254982,
0.0039041596464812756,
0.017589382827281952,
0.02279125526547432,
0.0067723533138632774,
0.007698110304772854,
-0.04941779002547264,
0.029580140486359596,
0.002671194728463888,
-0.01647626981139183,
0.031519822776317596,
-0.008728565648198128,
0.02196468599140644,
0.02858825773000717,
0.03744907304644585,
-0.028081296011805534,
0.009147360920906067,
0.015837056562304497,
0.04743402451276779,
0.02161201648414135,
-0.025039521977305412,
-0.005758428946137428,
-0.0352448895573616,
0.000665732251945883,
0.012178112752735615,
-0.010679268278181553,
-0.029249513521790504,
0.018537182360887527,
0.04002796858549118,
0.03420892357826233,
-0.04205581918358803,
0.0021366802975535393,
0.0009519316954538226,
-0.019374771043658257,
0.0007452894933521748,
-0.04906512051820755,
0.053958408534526825,
0.061805300414562225,
0.0044138771481812,
-0.023694971576333046,
0.013236121274530888,
0.014239024370908737,
-0.058234523981809616,
-0.03451751172542572,
0.025237899273633957,
0.008563252165913582,
0.05140155553817749,
-0.026075487956404686,
-0.0024411329068243504,
0.010144753381609917,
0.005857617128640413,
-0.009406352415680885,
0.01849309727549553,
-0.03456159308552742,
0.007136043626815081,
-0.03885975107550621,
-0.04602334648370743,
-0.028830718249082565,
-0.03804420307278633,
-0.013776145875453949,
0.016421165317296982,
0.056294843554496765,
0.03727274015545845,
-0.01804124005138874,
-0.0011372208828106523,
-0.02664857544004917,
0.012045862153172493,
0.0137100201100111,
0.0036644546780735254,
-0.00309136719442904,
0.020300528034567833,
-0.02309984154999256,
-0.023298216983675957,
0.02279125526547432,
0.00034405922633595765,
0.08547823131084442,
0.006287432741373777,
0.004948391579091549,
-0.039036087691783905,
-0.002330923918634653,
0.015848077833652496,
0.04408366605639458,
-0.030770398676395416,
-0.016994252800941467,
-0.01135154440999031,
-0.018294721841812134,
-0.0019631008617579937,
0.018746579065918922,
0.04871245101094246,
0.0353771410882473,
0.022901464253664017,
-0.01195769477635622,
0.018658412620425224,
0.027265748009085655,
0.03290845826268196,
-0.011527879163622856,
-0.010001481510698795,
-0.006607039365917444,
-0.011516857892274857,
0.03418688476085663,
0.00043670382001437247,
0.004785832948982716,
-0.00501727219671011,
0.008056290447711945,
0.0053368788212537766,
0.010976833291351795,
0.024157850071787834,
-0.024885229766368866,
0.01689506508409977,
0.024025598540902138,
-0.024466434493660927,
0.005414025392383337,
-0.009527582675218582,
-0.008337323553860188,
0.004080494400113821,
-0.0010118578793480992,
0.0015883896267041564,
-0.015252948738634586,
0.0071856374852359295,
0.02830171398818493,
0.022681046277284622,
-0.012607928365468979,
-0.02622978202998638,
-0.0013727928744629025,
-0.03453955426812172,
-0.015440303832292557,
-0.021446703001856804,
-0.0127622215077281,
-0.005179830826818943,
-0.004716952331364155,
-0.035112641751766205,
0.006816437002271414,
-0.035465311259031296,
-0.00196447828784585,
-0.008541210554540157,
0.01916537433862686,
0.030109144747257233,
-0.006965219508856535,
-0.017435090616345406,
0.0034826097544282675,
0.007560348603874445,
-0.030065059661865234,
-0.037471115589141846,
0.05576583743095398,
-0.01610155962407589,
-0.047698527574539185,
0.01609053835272789,
0.010370682924985886,
-0.0007859290926717222,
0.013059786520898342,
-0.004292646888643503,
-0.023717012256383896,
0.01888985186815262,
0.007080939132720232,
0.011252355761826038,
-0.006265391130000353,
0.02192060276865959,
-0.0013335308758541942,
-0.02984464168548584,
-0.04007205367088318,
0.013401434756815434,
-0.0011358432238921523,
0.0008327679825015366,
-0.016288913786411285,
-0.028830718249082565,
0.00774219399318099,
0.005841085687279701,
-0.006166202947497368,
0.01255282387137413,
0.0352228507399559,
-0.0013845026260241866,
0.03304070606827736,
-0.004342241212725639,
0.004234787076711655,
0.003504651365801692,
0.0072021689265966415,
0.016575459390878677,
0.0038848731201142073,
0.017148546874523163,
0.008932452648878098,
-0.012222196906805038,
-0.019055165350437164,
-0.010745394043624401,
-0.005452598445117474,
0.0032869884744286537,
0.04941779002547264,
-0.01316999550908804,
-0.04624376446008682,
0.0471695214509964,
0.02078544907271862,
-0.0023364343214780092,
-0.005609646439552307,
0.021094033494591713,
0.028742549940943718,
0.006314984988421202,
-0.007312378380447626,
0.0008541210554540157,
0.015815015882253647,
-0.002633999101817608,
0.001206101500429213,
-0.003515672404319048,
-0.01806328259408474,
0.010249452665448189,
-0.00866795051842928,
0.013225100003182888,
-0.006072524935007095,
-0.005031048320233822,
-0.03974142670631409,
0.011147657409310341,
-0.0050393142737448215,
0.017446110025048256,
0.04284932464361191,
0.020190319046378136,
-0.011009895242750645,
0.02356272004544735,
0.014261065982282162,
-0.027684543281793594,
-0.037515200674533844,
0.0010290780337527394,
-0.028367839753627777,
-0.020950762555003166,
-0.032820288091897964,
-0.012982639484107494,
0.01724773459136486,
-0.014834153465926647,
0.021832436323165894,
-0.014250044710934162,
0.021909581497311592,
0.0033310719300061464,
-0.04205581918358803,
0.006342537701129913,
-0.012089945375919342,
-0.01451454684138298,
-0.008712034672498703,
0.01689506508409977,
-0.03253374621272087,
-0.031519822776317596,
0.008546721190214157,
-0.006976240314543247,
0.009703917428851128,
0.028433965519070625,
0.011329501867294312,
0.02477502077817917,
0.031078984960913658,
0.0062378388829529285,
-0.02636203169822693,
0.011968715116381645,
-0.05585400387644768,
0.022681046277284622,
-0.01255282387137413,
-0.0007273805094882846,
-0.008320791646838188,
-0.02984464168548584,
-0.053164903074502945,
-0.015826035290956497,
0.004358772654086351,
-0.00016333343228325248,
-0.009130829013884068,
0.020157257094979286,
-0.013037743978202343,
0.0018198288744315505,
0.01929762400686741,
0.024025598540902138,
-0.03334929421544075,
0.006629081442952156,
0.0021325473207980394,
0.0027194111607968807,
-0.01528601162135601,
-0.007990164682269096,
-0.024069681763648987,
0.003165758214890957,
0.00461500883102417,
0.01078947726637125,
-0.005155033897608519,
0.011329501867294312,
0.02470889501273632,
0.009516561403870583,
0.043819162994623184,
-0.0035652664955705404,
0.006017420440912247,
-0.017159566283226013,
-0.027353914454579353,
-0.000661599391605705,
-0.0016985987313091755,
0.023650886490941048,
0.033966463059186935,
0.0313875712454319,
-0.02506156452000141,
-0.03019731119275093,
-0.022659003734588623,
-0.007731173187494278,
-0.03328316658735275,
-0.019121291115880013,
-0.0015263969544321299,
-0.009648812003433704,
-0.047742608934640884,
-0.01569378562271595,
-0.0068054161965847015,
0.005598625633865595,
0.02283533848822117,
0.027001244947314262,
-0.012288321740925312,
-0.01612360030412674,
-0.023430468514561653,
-0.01882372610270977,
0.01611258089542389,
0.017060378566384315,
0.021678142249584198,
-0.006414173636585474,
-0.006028441246598959,
-0.020950762555003166,
0.04276115447282791,
0.009411863051354885,
0.013941459357738495,
-0.01918741501867771,
-0.045273926109075546,
0.02235041931271553,
0.014018605463206768,
0.0027593618724495173,
0.005692303646355867,
0.04007205367088318,
-0.013423476368188858,
-0.009962908923625946,
0.06775659322738647,
-0.016575459390878677,
0.007295846939086914,
0.00024676520843058825,
0.005763939581811428,
0.019066184759140015,
0.0006702094688080251,
-0.009411863051354885,
0.015936246141791344,
-0.03094673343002796,
-0.005077887326478958,
-0.01472394447773695,
-0.011439711786806583,
-0.004802364390343428,
0.019793566316366196,
0.0007749081705696881,
-0.0015181312337517738,
-0.003072080435231328,
-0.056647513061761856,
-0.06480298936367035,
-0.0010373437544330955,
0.006265391130000353,
-0.026891035959124565,
0.0005610335501842201,
-0.01724773459136486,
0.009709427133202553,
0.013809208758175373,
-0.011059490032494068,
0.007483202498406172,
0.0471695214509964,
0.01769959181547165,
0.011103573255240917,
0.024510517716407776,
0.013092848472297192,
0.010701309889554977,
-0.013500622473657131,
0.005758428946137428,
-0.02084055356681347,
-0.012277301400899887,
0.02078544907271862,
-0.020542988553643227,
0.017413048073649406,
0.00509717408567667,
-0.011825443245470524,
0.020983824506402016,
0.007014813367277384,
-0.012012799270451069,
0.039058126509189606,
0.02008011005818844,
-0.006755821872502565,
0.009086745791137218,
0.00377190881408751,
-0.01648729108273983,
0.016961190849542618,
0.019099248573184013,
-0.003275967435911298,
-0.0029618714470416307,
0.017986135557293892,
0.015021509490907192,
-0.01846003532409668,
-0.023452511057257652,
0.015627659857273102,
0.038264621049165726,
-0.0034357707481831312,
0.026846952736377716,
-0.001443740096874535,
-0.013291225768625736,
-0.01612360030412674,
0.013346330262720585,
0.01614564284682274,
-0.03445138409733772,
0.020322570577263832,
0.0012412307551130652,
-0.00010736783588072285,
0.0078689344227314,
0.017446110025048256,
0.00006461873272201046,
0.023386385291814804,
-0.009753511287271976,
-0.016685668379068375,
-0.025766903534531593,
0.00132526527158916,
-0.005747408140450716,
-0.03462772071361542,
-0.030792441219091415,
0.01728079654276371,
-0.01916537433862686,
0.025436274707317352,
-0.027375956997275352,
-0.009698406793177128,
-0.008800202049314976,
-0.020664218813180923,
0.0017275286372750998,
0.011505836620926857,
-0.0026767051313072443,
0.03054998070001602,
-0.011627066880464554,
-0.02975647523999214,
-0.00943941529840231,
0.0025031256955116987,
-0.026141613721847534,
-0.004108046647161245,
-0.05757327005267143,
-0.0008899390231817961,
0.007620963733643293,
-0.008453043177723885,
0.004846448078751564,
0.02316596731543541,
-0.001312866690568626,
0.0034826097544282675,
-0.028962967917323112,
-0.00043567060492932796,
0.011009895242750645,
0.014007585123181343,
-0.016795877367258072,
-0.03425300866365433,
0.004598477389663458,
0.0030224863439798355,
-0.020146235823631287,
-0.024113764986395836,
-0.0353991836309433,
-0.005598625633865595,
-0.01800817809998989,
0.008971026167273521,
0.012640991248190403,
0.0024342448450624943,
-0.00549668213352561,
0.01431617047637701,
-0.03453955426812172,
-0.009340226650238037,
0.02192060276865959,
0.01471292320638895,
0.012056882493197918,
0.04642010107636452,
-0.03021935373544693,
0.00590170081704855,
-0.005110950209200382,
0.006618060637265444,
-0.034715887159109116,
-0.004973188508301973,
0.017534278333187103,
-0.004703176207840443,
-0.0010228788014501333,
0.04009409621357918,
0.011913610622286797,
-0.02398151531815529,
-0.02636203169822693,
-0.011103573255240917,
-0.02433418296277523,
0.003981306217610836,
-0.04500942304730415,
0.004386324901133776,
0.0353550985455513,
0.017986135557293892,
0.0019121289951726794,
0.012905493378639221,
-0.02622978202998638,
0.004526841454207897,
-0.013588789850473404,
-0.00019631008035503328,
-0.007218700367957354,
-0.02869846671819687,
-0.028962967917323112,
-0.0006571221747435629,
-0.0005200494779273868,
0.004951146896928549,
0.03323908522725105,
-0.008331812918186188,
-0.003760887775570154,
-0.00332831684499979,
-0.003854565555229783,
-0.02087361551821232,
-0.006298454012721777,
-0.010971322655677795,
-0.005179830826818943,
0.01352266501635313,
0.015859099105000496,
0.006711738184094429,
0.048095278441905975,
0.0216009970754385,
-0.015881141647696495,
-0.012288321740925312,
-0.0016930883284658194,
0.009968418627977371,
-0.03174024075269699,
0.010712331160902977,
0.09477988630533218,
-0.03409871459007263,
-0.008386917412281036,
0.011042958125472069,
-0.01390839647501707,
-0.021402619779109955,
0.011274397373199463,
-0.0018873319495469332,
0.03464976325631142,
-0.005245956126600504,
0.011715234257280827,
-0.0027855366934090853,
0.04057901352643967,
0.013478580862283707,
0.04205581918358803,
-0.012067903764545918,
0.00077284179860726,
0.043201994150877,
-0.0022386235650628805,
0.012784263119101524,
0.0010862491326406598,
0.029734432697296143,
0.005386473145335913,
0.032401494681835175,
-0.027640458196401596,
0.017368964850902557,
0.010657226666808128,
0.008205072022974491,
0.008734076283872128,
-0.01291651464998722,
0.030285479500889778,
0.011880547739565372,
0.03665556758642197,
-0.027287788689136505,
0.011472773738205433,
-0.032379452139139175,
-0.013886354863643646,
-0.015627659857273102,
-0.02821354568004608,
-0.007207679562270641,
-0.0038215029053390026,
0.005353410262614489,
0.004964923020452261,
0.0004897419712506235,
0.025788944214582443,
0.01884576678276062,
-0.017931031063199043,
0.0255464855581522,
0.015374178998172283,
-0.00590170081704855,
0.017071399837732315,
0.005044824443757534,
-0.0002452154003549367,
-0.02468685247004032,
-0.04384120553731918,
-0.020201340317726135,
0.007620963733643293,
-0.0010449206456542015,
0.03870546072721481,
-0.0235186368227005,
-0.03680986166000366,
0.01995887979865074,
0.02161201648414135,
-0.03226924315094948,
-0.01079498790204525
] | 2025-01-13 | 1 | 39805063 | [
"metastatic CRC",
"CRC",
"CAR-T cell therapy",
"CAR-T cell therapies",
"tumor heterogeneity",
"solid tumors",
"conventional treatment modalities",
"tumor infiltration",
"T-cell persistence",
"significant potential",
"Colorectal cancer",
"immune checkpoint inhibitors",
"limited options",
"high mortality rates",
"immunosuppressive microenvironment",
"CAR-T efficacy",
"practical solutions",
"prominent CRC-specific targets",
"physical barriers",
"hematologic malignancies",
"clinical trials",
"poor outcomes",
"Emerging strategies",
"a major global health burden",
"CAR-T",
"patients",
"logic-gated and dual-targeting CAR-T cells",
"advances",
"the treatment landscape",
"a promising avenue"
] | [] | 0 | 10.1200/JCO-24-02081 | [
"Ouladan",
"Orouji"
] | [
"Department of Pathology, McGill University, Montreal, QC, Canada.",
"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada."
] | [
"39805063"
] | [] | 10.7438 | 5.124182 |
39801735 | 38 | Monovalent Anti-CD3 Antibodies Effectively Eliminate the TCR-Positive Fraction of TCR-Deleted Allogeneic CAR-T Cells to Prevent GVHD. | Chimeric antigen receptor-transduced T (CAR-T) cell therapy is an effective cell therapy against advanced hematological tumors. However, the use of autologous T cells limits its timely and universal generation. Allogeneic CAR-T cell therapy may be a good alternative as a ready-to-use therapeutic. Graft-versus-host disease (GVHD) is an obstacle for allogeneic CAR-T cells, but can be prevented by TCR deletion through genome editing. However, the remaining TCR-positive cells must be eliminated by costly, large-scale magnetic cell separation. Therefore, an alternative method for removing TCR-positive cells is needed. In this study, we found that monovalent anti-CD3 Abs such as Fab and single-chain variable fragment (scFv), but not whole IgG, induce apoptosis of | [
0.016106318682432175,
0.006051407195627689,
0.04679601266980171,
0.06087173521518707,
-0.03791215270757675,
-0.06313308328390121,
-0.023201867938041687,
0.01897915080189705,
0.0019483915530145168,
-0.01897915080189705,
0.0009958285372704268,
0.0000984291109489277,
-0.04684216156601906,
0.027597647160291672,
0.01263353880494833,
-0.030320491641759872,
0.04541151225566864,
-0.020490560680627823,
0.026743873953819275,
0.03214341402053833,
0.024367153644561768,
0.046980611979961395,
0.00851465854793787,
0.00543992081657052,
-0.014318009838461876,
-0.013002737425267696,
0.043842416256666183,
0.015414070338010788,
-0.028174521401524544,
-0.05270319804549217,
0.0038996676448732615,
-0.015587132424116135,
-0.017133153975009918,
-0.02958209440112114,
0.006016794592142105,
0.07300916314125061,
0.0439116396009922,
0.025082476437091827,
-0.044165465980768204,
-0.027297673746943474,
0.043380916118621826,
0.018794551491737366,
0.02182890847325325,
0.08759253472089767,
-0.05247244983911514,
0.01535638328641653,
-0.006322538014501333,
-0.023721054196357727,
-0.012598926201462746,
-0.01758311688899994,
-0.010083755478262901,
-0.018598414957523346,
-0.039873525500297546,
0.03156654164195061,
-0.07360910624265671,
0.02741304785013199,
-0.047442108392715454,
-0.014906421303749084,
0.0038881301879882812,
0.029743617400527,
-0.027943771332502365,
-0.006080250721424818,
0.018333053216338158,
-0.015656357631087303,
-0.03627382963895798,
0.018933001905679703,
-0.06013333424925804,
-0.010354886762797832,
-0.004739019088447094,
0.03195881471037865,
-0.04171952232718468,
-0.046819087117910385,
0.00775895407423377,
-0.024597903713583946,
0.015264083631336689,
0.027643797919154167,
-0.005754317156970501,
0.010874073021113873,
0.009749168530106544,
-0.016014019027352333,
0.04813435673713684,
0.01599094457924366,
0.000880453793797642,
-0.030851216986775398,
-0.003960239235311747,
-0.015021796338260174,
-0.0019267587922513485,
-0.007989703677594662,
-0.031474240124225616,
-0.007672423031181097,
-0.022232720628380775,
0.015414070338010788,
-0.04213486984372139,
0.04845740646123886,
-0.015529445372521877,
0.010366423986852169,
-0.015817882493138313,
-0.07383985817432404,
0.0032622218132019043,
0.02630545012652874,
0.032743360847234726,
-0.007216692436486483,
-0.01547175832092762,
-0.011929752305150032,
0.049841903150081635,
0.014883346855640411,
-0.04407316446304321,
0.018425352871418,
0.0012604694347828627,
-0.0064725251868367195,
0.08648493885993958,
-0.03590463101863861,
-0.014433384872972965,
0.037704478949308395,
-0.04100419580936432,
-0.06437912583351135,
-0.02549782581627369,
0.014202635735273361,
-0.0025223810225725174,
0.00047772368998266757,
0.008803095668554306,
0.04635758697986603,
0.045203838497400284,
-0.03664303198456764,
-0.018852239474654198,
-0.013844973407685757,
0.07490130513906479,
-0.015817882493138313,
-0.05510299652814865,
-0.03542005643248558,
0.06304077804088593,
0.018575340509414673,
0.025290152058005333,
-0.0256593506783247,
-0.04414239153265953,
0.001962813548743725,
-0.014364159666001797,
-0.009772243909537792,
-0.04557303711771965,
0.0014292050618678331,
0.021586621180176735,
-0.049611154943704605,
-0.008647339418530464,
0.013279637321829796,
-0.024021029472351074,
-0.038973599672317505,
0.011652852408587933,
0.020582860335707664,
-0.01263353880494833,
0.03749680519104004,
-0.03611230477690697,
0.05104180425405502,
0.06700967252254486,
-0.0017710028914734721,
0.00543992081657052,
-0.028428345918655396,
-0.017375441268086433,
0.047119058668613434,
-0.02319033071398735,
-0.06290233135223389,
-0.025405526161193848,
-0.01745620369911194,
-0.021921208128333092,
-0.03348176181316376,
0.004485194571316242,
0.008035853505134583,
0.00044202961726114154,
0.049703456461429596,
-0.035443130880594254,
-0.004199642222374678,
0.002424312522634864,
-0.04086574539542198,
-0.09783781319856644,
-0.0071993861347436905,
-0.047534409910440445,
0.002717076102271676,
0.026766948401927948,
0.02494402788579464,
-0.036020006984472275,
-0.008976157754659653,
0.021840445697307587,
0.02533630095422268,
0.021771220490336418,
-0.007372448220849037,
-0.02918981947004795,
0.0002278651954839006,
0.011133666150271893,
0.004580378998070955,
-0.06516367942094803,
-0.006437912583351135,
0.018829165026545525,
-0.025313226506114006,
0.02413640357553959,
-0.008214684203267097,
0.00525532104074955,
-0.015552520751953125,
0.036804553121328354,
0.009431888349354267,
-0.028012996539473534,
-0.04924195632338524,
0.04139647260308266,
-0.026743873953819275,
-0.0406811460852623,
-0.008768483065068722,
-0.038904376327991486,
-0.0036891086492687464,
-0.016233231872320175,
0.04259636998176575,
-0.01198743935674429,
-0.007522435858845711,
0.039388950914144516,
-0.012218189425766468,
-0.035535432398319244,
0.024274853989481926,
0.001010971493087709,
-0.022428857162594795,
0.012437401339411736,
0.05916418880224228,
0.009166526608169079,
0.03816597908735275,
-0.03308948874473572,
-0.034820109605789185,
-0.03486625850200653,
0.022751906886696815,
-0.057272039353847504,
-0.03334331139922142,
0.01251816377043724,
-0.005812004674226046,
0.008895395323634148,
-0.019371425732970238,
-0.011883602477610111,
0.017167767509818077,
0.021252034232020378,
-0.03509700670838356,
-0.02163277193903923,
-0.022428857162594795,
0.02935134433209896,
0.0037121835630387068,
0.054733794182538986,
-0.027297673746943474,
-0.0042832884937524796,
0.019186826422810555,
0.027782246470451355,
-0.039227426052093506,
-0.005633173510432243,
-0.021459709852933884,
-0.011300959624350071,
-0.06484062969684601,
0.021563546732068062,
0.03615845739841461,
-0.020329035818576813,
0.00873964000493288,
0.0070840115658938885,
0.010279892943799496,
0.03784292936325073,
0.054641496390104294,
0.05971798673272133,
-0.03304333612322807,
-0.003230493748560548,
-0.012414325959980488,
-0.018598414957523346,
0.0014544433215633035,
-0.04190412163734436,
-0.0020075212232768536,
-0.023178793489933014,
0.0341278612613678,
0.016394756734371185,
0.02886676974594593,
0.030320491641759872,
0.01919836364686489,
0.009535725228488445,
-0.008906933479011059,
0.037150681018829346,
-0.020386723801493645,
-0.053441599011421204,
0.014433384872972965,
0.0024747890420258045,
0.012345101684331894,
0.030482016503810883,
0.01897915080189705,
-0.014721821993589401,
0.03325100988149643,
0.00578316068276763,
-0.012841212563216686,
-0.029212893918156624,
-0.011087516322731972,
-0.006489831488579512,
0.02338646724820137,
0.002774763386696577,
-0.030897365882992744,
0.008831939660012722,
-0.014537222683429718,
-0.008606958203017712,
-0.01952141337096691,
-0.0011047135340049863,
0.02283266931772232,
-0.030205117538571358,
0.021725071594119072,
-0.04891890659928322,
-0.0007113576284609735,
-0.032651063054800034,
-0.0034900871105492115,
-0.012495088391005993,
-0.004822665825486183,
-0.0017161997966468334,
0.005128408782184124,
-0.021413559094071388,
0.003963123541325331,
0.02072131074965,
0.04446544125676155,
0.01146825309842825,
-0.007464748341590166,
0.026720799505710602,
0.035143159329891205,
0.01910606399178505,
-0.008058927953243256,
-0.005206286907196045,
-0.0905461311340332,
0.020582860335707664,
-0.047765158116817474,
-0.008387746289372444,
-0.011681696400046349,
-0.03876592591404915,
0.011410566046833992,
0.009899156168103218,
-0.01764080300927162,
0.017444666475057602,
-0.048180509358644485,
0.024344079196453094,
-0.03172806277871132,
-0.020375186577439308,
-0.03551235795021057,
0.06451757997274399,
-0.02234809473156929,
0.01003760565072298,
-0.0035708495415747166,
-0.03606615588068962,
-0.034174010157585144,
0.017075467854738235,
-0.025220926851034164,
0.0036400742828845978,
0.04522691294550896,
-0.03691992908716202,
0.05141100287437439,
-0.010516411624848843,
-0.020086748525500298,
-0.0039083207957446575,
0.027482273057103157,
0.010804847814142704,
0.0024618094321340322,
-0.01125480979681015,
0.008866552263498306,
0.007332067470997572,
-0.0009064131299965084,
0.018252290785312653,
0.03269721195101738,
-0.028959069401025772,
0.027159223333001137,
0.011635546572506428,
-0.00028284848667681217,
0.046403735876083374,
0.009466500952839851,
-0.04418854042887688,
0.00689364317804575,
0.06299462914466858,
0.0627177283167839,
-0.02351338043808937,
0.04541151225566864,
-0.022601919248700142,
-0.048411257565021515,
-0.020744385197758675,
-0.04155799746513367,
0.004808243829756975,
0.0027329400181770325,
-0.03763525187969208,
0.013706523925065994,
0.02331724390387535,
0.025890100747346878,
0.025705501437187195,
-0.006570593919605017,
0.025705501437187195,
-0.03837365284562111,
-0.016625504940748215,
-0.04628836363554001,
-0.009749168530106544,
0.013810360804200172,
-0.0024142172187566757,
0.007782028988003731,
-0.06373302638530731,
0.027228448539972305,
0.0023897001519799232,
0.0002132630761479959,
0.01761772856116295,
0.009126145392656326,
-0.030597392469644547,
0.06659432500600815,
-0.023697979748249054,
0.09663791209459305,
0.019602175801992416,
0.015183321200311184,
0.00999145582318306,
0.004871699959039688,
-0.03535083308815956,
-0.04679601266980171,
0.039873525500297546,
-0.013614224269986153,
0.03733528032898903,
0.031128115952014923,
0.020167510956525803,
-0.035212382674217224,
0.011150972917675972,
0.02299419417977333,
0.02727459743618965,
0.02623622491955757,
0.025405526161193848,
-0.02354799211025238,
-0.04762670770287514,
0.04015042260289192,
-0.0420425683259964,
0.01087984163314104,
0.027943771332502365,
-0.03179728984832764,
0.006299463100731373,
-0.02918981947004795,
-0.007170542608946562,
-0.013637298718094826,
0.02519785240292549,
0.011283653788268566,
0.004395779222249985,
-0.05187249928712845,
-0.02711307257413864,
0.02798992209136486,
0.005090912338346243,
-0.04141954705119133,
-0.004560188390314579,
0.046496037393808365,
-0.017813866958022118,
0.021782757714390755,
-0.0428040437400341,
0.048088207840919495,
-0.03975814953446388,
0.00827237218618393,
0.02218656986951828,
-0.02942056953907013,
0.019279126077890396,
0.008133921772241592,
0.012587388046085835,
0.019175289198756218,
-0.06728657335042953,
-0.007257073651999235,
-0.018286902457475662,
-0.0029420568607747555,
0.010320274159312248,
-0.007285917177796364,
-0.0026651574298739433,
-0.025082476437091827,
0.005304355639964342,
-0.042665593326091766,
0.01125480979681015,
0.025405526161193848,
0.01606016978621483,
-0.041304171085357666,
0.024828651919960976,
0.0013426740188151598,
-0.008012778125703335,
0.033943261951208115,
0.04045039787888527,
-0.018644563853740692,
0.00020929706806782633,
-0.037127602845430374,
0.01991368643939495,
-0.021817371249198914,
-0.009604950435459614,
0.013014275580644608,
-0.013279637321829796,
0.02828989550471306,
0.015944793820381165,
0.010147212073206902,
0.03341253474354744,
0.009685712866485119,
-0.00015088857617229223,
-0.0035016245674341917,
-0.008012778125703335,
-0.013891123235225677,
0.006812880747020245,
0.0387197770178318,
-0.00867618340998888,
-0.0016541859367862344,
-0.015529445372521877,
0.034174010157585144,
0.019486799836158752,
-0.0020161743741482496,
-0.004092920105904341,
-0.008993464522063732,
-0.0044275070540606976,
0.012852750718593597,
0.02143663354218006,
-0.003579502459615469,
-0.005388002377003431,
0.008278140798211098,
-0.011064441874623299,
-0.00032142692361958325,
-0.004701522178947926,
-0.0007113576284609735,
0.03255876153707504,
0.0463806614279747,
0.02088283561170101,
0.029997441917657852,
-0.026836173608899117,
0.02413640357553959,
-0.0030689691193401814,
-0.004600569140166044,
0.030735841020941734,
-0.011635546572506428,
-0.0302974171936512,
-0.02591317519545555,
-0.056718241423368454,
-0.009651100262999535,
-0.012575850822031498,
-0.009628025814890862,
-0.03422015905380249,
-0.005682208109647036,
-0.006962867919355631,
0.00993953738361597,
0.016533205285668373,
-0.025313226506114006,
-0.03860440105199814,
-0.04028887301683426,
-0.03675840422511101,
-0.01287582516670227,
0.0400811992585659,
-0.01722545549273491,
-0.012114351615309715,
0.03788907825946808,
-0.011647083796560764,
-0.03315871208906174,
-0.026651574298739433,
0.03101273998618126,
-0.0193598885089159,
-0.0671481192111969,
-0.0014580488204956055,
-0.01572558283805847,
0.027320748195052147,
-0.0009871755028143525,
0.006420606281608343,
0.005930263549089432,
-0.013775749132037163,
-0.03479703515768051,
0.01362576149404049,
-0.00813969038426876,
0.002024827292189002,
-0.00789740402251482,
0.013095037080347538,
-0.02072131074965,
0.016660118475556374,
-0.027920696884393692,
-0.012737375684082508,
-0.02981284260749817,
-0.0009720325469970703,
-0.0196598619222641,
-0.0121489642187953,
-0.01754850335419178,
0.004724597092717886,
-0.016463981941342354,
-0.016394756734371185,
0.009385738521814346,
-0.013902661390602589,
-0.017986929044127464,
-0.0387197770178318,
0.031220415607094765,
-0.014848734252154827,
0.008866552263498306,
0.01131826639175415,
-0.004955346696078777,
0.03664303198456764,
0.027551498264074326,
0.010758697986602783,
0.011600933969020844,
-0.014606446959078312,
0.027205372229218483,
-0.02270575612783432,
-0.02494402788579464,
-0.014375697821378708,
0.06733272224664688,
-0.015552520751953125,
0.007608966901898384,
-0.05542604252696037,
-0.0038852456491440535,
-0.026605423539876938,
-0.010401036590337753,
0.03830442577600479,
0.032351087778806686,
0.03668918088078499,
0.0029492678586393595,
-0.03876592591404915,
0.02942056953907013,
0.014375697821378708,
0.009414582513272762,
-0.014329547993838787,
-0.007903172634541988,
-0.002985322382301092,
-0.021009746938943863,
-0.018402276560664177,
-0.04437313973903656,
-0.009904924780130386,
0.0242979284375906,
0.000055704385886201635,
-0.01547175832092762,
-0.008762714453041553,
0.011024060659110546,
0.06640972197055817,
0.027597647160291672,
-0.03493548184633255,
0.007141699083149433,
0.03447398543357849,
0.0014155043754726648,
-0.0013095038011670113,
-0.0070840115658938885,
0.0002455319627188146,
-0.030574316158890724,
-0.0058610388077795506,
-0.004041001666337252,
-0.01519485842436552,
0.00793201569467783,
-0.019129138439893723,
-0.01479104720056057,
-0.010545254684984684,
0.00837044045329094,
0.005082258954644203,
-0.002780532231554389,
-0.01631399430334568,
-0.011681696400046349,
-0.030851216986775398,
0.025682425126433372,
-0.011929752305150032,
-0.03246646374464035,
0.030966591089963913,
-0.01851765252649784,
-0.007170542608946562,
0.009443425573408604,
-0.03901975229382515,
0.02365182898938656,
-0.007862791419029236,
-0.014294935390353203,
0.016463981941342354,
-0.016071707010269165,
-0.04077344760298729,
-0.00028951858985237777,
0.008803095668554306,
0.00379871460609138,
0.0032045345287770033,
-0.008583883754909039,
0.0371045283973217,
-0.017410054802894592,
0.0025411294773221016,
0.011739383451640606,
0.005460111424326897,
-0.013129649683833122,
0.06871721893548965,
0.061056334525346756,
-0.02951286919414997,
0.028405271470546722,
-0.008751177228987217,
-0.004332323092967272,
-0.013729598373174667,
-0.02607470005750656,
0.011658621951937675,
-0.015321770682930946,
-0.02575165033340454,
-0.0033516373950988054,
0.09059228003025055,
0.015933256596326828,
0.002852641511708498,
-0.028105296194553375,
-0.0067551932297647,
0.015483295544981956,
0.005722589325159788,
-0.0270207729190588,
-0.02727459743618965,
0.00677826814353466,
-0.018886851146817207,
0.004240022972226143,
-0.022763444110751152,
-0.040104273706674576,
0.007101317867636681,
0.006887874566018581,
0.02607470005750656,
0.007372448220849037,
0.0019916570745408535,
-0.020894372835755348,
0.0007156842038966715,
-0.01955602504312992,
-0.017883090302348137,
-0.002856967970728874,
0.022763444110751152,
0.026882324367761612,
-0.009922231547534466,
-0.01177399605512619,
-0.0262131504714489,
0.008762714453041553,
0.02439022809267044,
-0.0026146809104830027,
0.042896341532468796,
0.0014941033441573381,
0.01686779223382473,
-0.004681331571191549,
0.017017779871821404,
-0.008687720634043217,
-0.0036833398044109344,
0.021621234714984894,
0.01806769147515297,
0.008001240901648998,
-0.02159815840423107,
-0.039873525500297546,
-0.024759428575634956,
0.013660374097526073,
-0.0029434990137815475,
0.04061192274093628,
0.007707035169005394,
0.01839073933660984,
0.006380225531756878,
0.03371251001954079,
-0.03440475836396217,
0.01263353880494833,
0.02870524488389492,
0.005768739152699709,
-0.022001970559358597,
0.05154945328831673,
-0.020998209714889526,
-0.015448682941496372,
-0.001284265541471541,
-0.033458687365055084,
-0.025405526161193848,
-0.011029829271137714,
-0.016913942992687225,
0.02812837064266205,
0.0043611666187644005,
-0.026351599022746086,
-0.008018547669053078,
-0.010799079202115536,
0.0283821951597929,
-0.004891890566796064,
-0.014802584424614906,
0.018333053216338158,
-0.02234809473156929,
0.022428857162594795,
0.03071276657283306,
-0.0011753805447369814,
0.00042111793300136924,
-0.0289359949529171,
0.0016354374820366502,
0.007585891988128424,
-0.037450652569532394,
-0.02186352014541626,
0.007326298393309116,
-0.028036070987582207,
-0.019417574629187584,
0.005480302032083273,
-0.03103581629693508,
-0.03078199177980423,
0.006034100893884897,
-0.01303735002875328,
0.009928000159561634,
0.0006010304787196219,
-0.0330202616751194,
0.00883770827203989,
0.014260322786867619,
0.01884070225059986,
-0.006864799186587334,
0.013741136528551579,
-0.013256561942398548,
-0.0170639306306839,
0.004289057571440935,
-0.01282967533916235,
-0.01482565887272358,
-0.013014275580644608,
-0.008549271151423454,
-0.013810360804200172,
-0.03431246057152748,
0.016002481803297997,
-0.02215195819735527,
0.01423724740743637,
-0.03539698198437691,
0.011895139701664448,
0.0017681184690445662,
-0.016487056389451027,
0.005370696075260639,
0.03415093570947647,
-0.023167256265878677,
-0.008105078712105751,
0.0015979406889528036,
0.02822067029774189,
-0.04631143808364868,
0.027043849229812622,
-0.026836173608899117,
0.026605423539876938,
0.03763525187969208,
-0.08122384548187256,
0.001283544464968145,
-0.004294826183468103,
-0.014664134941995144,
-0.004811128135770559,
0.014860271476209164,
-0.04554996266961098,
-0.010245280340313911,
0.030020518228411674,
-0.011733614839613438,
-0.014398772269487381,
0.00021434470545500517,
0.024805577471852303,
0.014052648097276688,
0.02325955592095852,
-0.029282119125127792,
-0.02225579507648945,
-0.06474832445383072,
0.002929077250882983,
0.021528933197259903,
0.0009114607819356024,
-0.000011216366146982182,
0.006120631936937571,
0.015021796338260174,
-0.036735329777002335,
0.031312715262174606,
-0.02147124707698822,
-0.01903683878481388,
-0.05459534749388695,
-0.0014537222450599074,
0.023409543558955193,
0.004891890566796064,
-0.03341253474354744,
0.040104273706674576,
-0.029997441917657852,
-0.03652765601873398,
0.03272028639912605,
-0.012979662977159023,
0.025867026299238205,
0.01644090563058853,
-0.01806769147515297,
0.0012287413701415062,
0.036573804914951324,
0.005817773286253214,
-0.03615845739841461,
0.014710284769535065,
-0.026005474850535393,
0.01991368643939495,
0.012160501442849636,
-0.013856510631740093,
0.012448938563466072,
-0.02325955592095852,
-0.025867026299238205,
0.01139902789145708,
-0.0004344581684563309,
-0.01771002821624279,
0.006501368712633848,
0.03470473363995552,
0.007107086479663849,
0.02630545012652874,
-0.017340829595923424,
0.04942655563354492,
0.0529339499771595,
-0.027597647160291672,
-0.009108838625252247,
-0.029628243297338486,
-0.03583540767431259,
0.01764080300927162,
-0.04324246942996979,
0.006553287617862225,
-0.026097774505615234,
0.018598414957523346,
-0.024528678506612778,
0.013429624028503895,
-0.00004006569361081347,
0.006899411790072918,
-0.017963852733373642,
0.009276132099330425,
-0.009512650780379772,
-0.0023363393265753984,
-0.02079053595662117,
-0.026674648746848106,
-0.019602175801992416,
-0.013983422890305519,
-0.024182554334402084,
0.0007795008714310825,
0.003256453201174736,
0.013129649683833122,
-0.008918470703065395,
0.008566576987504959,
-0.011335572227835655,
-0.011058672331273556,
-0.010187593288719654,
0.010845229029655457,
-0.013614224269986153,
-0.005892767105251551,
-0.04661140963435173,
-0.016487056389451027,
0.007320529781281948,
-0.014041110873222351,
0.03493548184633255,
-0.052887797355651855,
0.004687100648880005,
-0.04079652205109596,
-0.02965131774544716,
-0.025567051023244858,
0.026882324367761612,
-0.0070551675744354725,
0.009604950435459614,
-0.03830442577600479,
0.050488002598285675,
0.005930263549089432,
0.013164262287318707,
-0.0332740880548954,
0.01797538995742798,
0.013741136528551579,
0.0338740348815918,
-0.0006388878682628274,
-0.003602577606216073,
-0.015587132424116135,
0.052980098873376846,
0.024413302540779114,
-0.0160832442343235,
-0.03087429143488407,
-0.010839460417628288,
0.0051485993899405,
-0.006512906402349472,
0.031058890745043755,
0.011260578408837318,
0.031058890745043755,
0.0302974171936512,
-0.027551498264074326,
-0.0033602905459702015,
-0.01813691481947899,
0.01008952409029007,
0.030897365882992744,
0.002718518255278468,
0.02990514226257801,
-0.02517477609217167,
0.025082476437091827,
-0.007216692436486483,
-0.020732847973704338,
-0.0036458431277424097,
-0.025543976575136185,
0.01355653628706932,
-0.029605168849229813,
-0.015771731734275818,
0.031312715262174606,
-0.02734382264316082,
-0.004173682536929846,
-0.019648324698209763,
0.050026506185531616,
0.01731775514781475,
0.03195881471037865,
0.025220926851034164,
0.039388950914144516,
0.02845142036676407,
-0.011237503960728645,
-0.025451676920056343,
0.02725152298808098,
-0.023005731403827667,
0.044003941118717194,
-0.029720542952418327,
-0.012783525511622429,
0.019763700664043427,
-0.017087005078792572,
-0.02646697498857975,
0.02105589769780636,
0.019809849560260773,
0.03398941084742546,
-0.0009273248142562807,
-0.06257928162813187,
0.037289127707481384,
-0.023144181817770004,
-0.02815144695341587,
0.017571579664945602,
0.018633026629686356,
0.004839972127228975,
0.0023478767834603786,
0.03948124870657921,
-0.026674648746848106,
-0.00032863786327652633,
0.016325531527400017,
0.03424323350191116,
0.003977545537054539,
-0.02655927464365959,
-0.010533717460930347,
-0.03934279829263687,
0.03168191388249397,
0.0051312935538589954,
-0.017444666475057602,
-0.01810230314731598,
0.005122640170156956,
0.046172987669706345,
0.023478766903281212,
-0.011035597883164883,
-0.04220409318804741,
0.019452188163995743,
-0.037289127707481384,
-0.03343561291694641,
-0.05085720121860504,
0.01952141337096691,
0.03262798860669136,
-0.03791215270757675,
-0.01551790814846754,
0.03484318405389786,
-0.02462097816169262,
-0.027874546125531197,
-0.00895308330655098,
0.036827631294727325,
0.010193361900746822,
0.034174010157585144,
-0.032651063054800034,
0.01638321951031685,
0.013002737425267696,
0.024851728230714798,
0.023628754541277885,
0.009651100262999535,
-0.017248529940843582,
-0.0039054362569004297,
-0.06267157942056656,
-0.0055726016871631145,
-0.0003652332816272974,
-0.024182554334402084,
-0.010914454236626625,
0.0030026286840438843,
0.037935227155685425,
0.019740624353289604,
0.0038362115155905485,
0.006559056229889393,
-0.026420824229717255,
0.030343567952513695,
0.0041159954853355885,
0.0024473874364048243,
-0.0021921207662671804,
0.01071831677109003,
-0.012022051960229874,
-0.009010770358145237,
-0.009379969909787178,
0.007159004919230938,
0.05390309542417526,
0.021886596456170082,
0.02782839722931385,
-0.03389710932970047,
-0.015806345269083977,
0.004300594795495272,
0.044973090291023254,
-0.009864543564617634,
0.00492073455825448,
0.007026324048638344,
-0.026351599022746086,
0.013498849235475063,
0.030158966779708862,
0.03117426484823227,
0.03491240739822388,
0.017363904044032097,
0.002903117798268795,
0.03055124171078205,
0.026097774505615234,
0.005330314859747887,
-0.015540982596576214,
-0.005670670419931412,
-0.010925991460680962,
-0.0018027309561148286,
0.018771477043628693,
0.017329292371869087,
-0.021102046594023705,
-0.021125122904777527,
0.009587644599378109,
0.011693233624100685,
0.05367234721779823,
0.012414325959980488,
-0.012229726649820805,
0.0002457122318446636,
-0.020732847973704338,
-0.03311256319284439,
0.014075723476707935,
0.018806088715791702,
-0.012587388046085835,
-0.010776004754006863,
-0.0026045856066048145,
-0.02143663354218006,
-0.056395191699266434,
0.018933001905679703,
-0.007118623703718185,
0.01042988058179617,
0.0011761016212403774,
-0.02743612229824066,
0.018183065578341484,
0.0006360035040415823,
-0.020675159990787506,
-0.014802584424614906,
-0.03567388281226158,
-0.01742159202694893,
-0.014744896441698074,
-0.02082514762878418,
-0.008266602642834187,
-0.009270363487303257,
-0.023882579058408737,
-0.008151228539645672,
-0.008918470703065395,
0.023767204955220222,
0.0011991766514256597,
-0.036896854639053345,
0.016498593613505363,
-0.022809594869613647,
-0.017052393406629562,
-0.02990514226257801,
0.05685669183731079,
-0.0007924805395305157,
-0.013418086804449558,
0.031381938606500626,
0.005823541898280382,
-0.0024545984342694283,
0.013937273062765598,
0.011641315184533596,
-0.030574316158890724,
0.007383985910564661,
-0.007233998738229275,
0.01890992559492588,
-0.02105589769780636,
0.012748912908136845,
0.00557837076485157,
0.0030112818349152803,
-0.027136148884892464,
-0.020455949008464813,
-0.010401036590337753,
-0.00018766429275274277,
-0.010060681030154228,
-0.026490049436688423,
0.04107342287898064,
-0.02193274535238743,
0.016821643337607384,
0.005437036510556936,
0.0060687134973704815,
-0.0020089633762836456,
-0.007060936652123928,
-0.006253313273191452,
0.001760907587595284,
-0.004358282312750816,
-0.032258789986371994,
0.004785168915987015,
0.007453210651874542,
0.004603453911840916,
-0.0037842928431928158,
-0.013187337666749954,
-0.009247289039194584,
-0.01813691481947899,
-0.005073606036603451,
0.004819781519472599,
0.03512008488178253,
-0.03655073046684265,
-0.05851808935403824,
0.04854970797896385,
0.0024661358911544085,
-0.02575165033340454,
-0.011075979098677635,
0.009766475297510624,
0.012852750718593597,
-0.0022267333697527647,
-0.021851982921361923,
0.005105333868414164,
0.052103251218795776,
-0.01052794884890318,
-0.00203492259606719,
0.04437313973903656,
-0.024920951575040817,
0.0036141150631010532,
-0.0031410783994942904,
0.013048887252807617,
-0.0007989703444764018,
0.015217933803796768,
-0.024113329127430916,
0.008191609755158424,
0.010654861107468605,
-0.027228448539972305,
0.06299462914466858,
0.034889332950115204,
0.01813691481947899,
0.03807367756962776,
0.019486799836158752,
-0.01696009188890457,
-0.0015085252234712243,
-0.03772755339741707,
-0.023628754541277885,
-0.030574316158890724,
-0.016048632562160492,
-0.04550381377339363,
0.01177399605512619,
-0.01362576149404049,
-0.008901163935661316,
-0.006789805833250284,
0.024920951575040817,
0.007839716039597988,
-0.025543976575136185,
0.005468764808028936,
-0.007383985910564661,
-0.006957099307328463,
-0.009853006340563297,
-0.017813866958022118,
-0.026836173608899117,
-0.013983422890305519,
0.0007261400460265577,
-0.013844973407685757,
0.027713021263480186,
0.03366636112332344,
-0.01231048908084631,
0.01758311688899994,
0.025797801092267036,
0.014883346855640411,
0.0016772608505561948,
0.002248366130515933,
-0.048965055495500565,
0.0025194967165589333,
-0.03128964081406593,
-0.009056920185685158,
0.003778523998335004,
-0.029051369056105614,
-0.020848222076892853,
-0.004508269485086203,
0.010320274159312248,
-0.00023868157586548477,
0.007724341470748186,
-0.012368176132440567,
-0.014479534700512886,
0.00008179891301551834,
0.000014669722986582201,
-0.001016019145026803,
-0.036343056708574295,
0.049380406737327576,
-0.006011025980114937,
-0.014767971821129322,
0.01025104895234108,
-0.006951330695301294,
-0.047765158116817474,
0.016002481803297997,
-0.0003847027837764472,
0.019348351284861565,
-0.0070840115658938885,
-0.01183745265007019,
0.010118368081748486,
-0.0253593772649765,
0.037935227155685425,
0.026882324367761612,
0.01167592778801918,
-0.029282119125127792,
-0.04031194746494293,
-0.015887107700109482,
0.028012996539473534,
0.0283821951597929,
0.03392018377780914,
0.04102727025747299,
-0.02147124707698822,
-0.027366897091269493,
-0.017006242647767067,
0.006847493350505829,
-0.02365182898938656,
-0.020386723801493645,
0.009985687211155891,
0.02662849985063076,
-0.03142809122800827,
-0.00394870201125741,
-0.011225965805351734,
0.06368687748908997,
0.007089780177921057,
0.015044871717691422,
-0.00032160719274543226,
0.01858687773346901,
-0.007159004919230938,
-0.011895139701664448,
0.010885610245168209,
0.021125122904777527,
0.02322494238615036,
0.0012965240748599172,
0.022001970559358597,
-0.024205628782510757,
0.038350578397512436,
0.01606016978621483,
0.028728319332003593,
-0.02990514226257801,
-0.057272039353847504,
0.008012778125703335,
0.01910606399178505,
-0.00789740402251482,
0.0005090912454761565,
0.016729343682527542,
-0.01641783118247986,
-0.03751987963914871,
0.03371251001954079,
-0.01589864492416382,
-0.022821132093667984,
-0.015494832769036293,
-0.017894627526402473,
0.012622000649571419,
-0.03445091098546982,
-0.010816385969519615,
0.00793201569467783,
0.001889261999167502,
-0.007378217298537493,
-0.01794077828526497,
-0.011035597883164883,
0.00882040150463581,
-0.005079374648630619,
-0.04215794429183006,
-0.009870312176644802,
-0.0028771585784852505,
-0.03941202536225319,
-0.06387148052453995,
0.014964109286665916,
0.016683192923665047,
-0.02948979288339615,
0.0009107396472245455,
-0.0008645897614769638,
0.02189813368022442,
0.031128115952014923,
-0.04342706874012947,
-0.008237759582698345,
0.029328269883990288,
0.03968892619013786,
0.012887363322079182,
0.007274379953742027,
0.024528678506612778,
0.020213661715388298,
-0.014318009838461876,
-0.01897915080189705,
-0.02685924805700779,
0.008508889935910702,
0.026443898677825928,
0.009005001746118069,
0.011058672331273556,
0.023305704817175865,
-0.02055978588759899,
0.010793310590088367,
-0.01914067566394806,
-0.03299718722701073,
0.04499616473913193,
-0.002350761089473963,
-0.002525265561416745,
-0.028589870780706406,
-0.0077762603759765625,
-0.005514914635568857,
0.014202635735273361,
0.034174010157585144,
-0.006547518540173769,
-0.0024574827402830124,
0.0038333269767463207,
0.04654218629002571,
-0.03885822743177414,
-0.014594909735023975,
0.04582686349749565,
0.03458935767412186,
0.000880453793797642,
0.0017854247707873583,
0.01267968863248825,
-0.031612690538167953,
-0.038512103259563446,
-0.00017216079868376255,
-0.013568074442446232,
-0.01894453912973404,
0.009253057651221752,
0.006882105488330126,
0.012183576822280884,
0.019417574629187584,
0.020582860335707664,
0.015610207803547382,
-0.025682425126433372,
-0.0012777757365256548,
-0.017179304733872414,
-0.037935227155685425,
-0.010320274159312248,
-0.022082732990384102,
0.0011357205221429467,
-0.0060052573680877686,
0.007799335289746523,
-0.03535083308815956,
0.023271093145012856,
-0.00623600697144866,
0.012079739011824131,
0.008099309168756008,
0.009754938073456287,
-0.03332023695111275,
0.011237503960728645,
-0.0071647739969193935,
0.008480045944452286,
-0.023051880300045013,
-0.013002737425267696,
-0.03948124870657921,
-0.015460220165550709,
-0.002513728104531765,
0.0008674741256982088,
-0.05630289390683174,
0.009553031995892525,
0.0036948772612959146,
-0.006195625755935907,
0.02322494238615036,
0.02075592242181301,
-0.0014984299195930362,
-0.0005195470293983817,
-0.02471327781677246,
0.00565336411818862,
0.0066513558849692345,
0.03198188915848732,
-0.010937529616057873,
-0.009201138280332088,
-0.016406293958425522,
-0.008399284444749355,
-0.02782839722931385,
-0.040819596499204636,
-0.029535943642258644,
-0.000405253900680691,
-0.014883346855640411,
0.01595633290708065,
-0.0038217895198613405,
-0.023109568282961845,
-0.006737886928021908,
0.03172806277871132,
-0.03119734115898609,
-0.0054572271183133125,
0.006385994143784046,
0.006726349703967571,
0.012852750718593597,
0.05334929749369621,
-0.014744896441698074,
0.010106830857694149,
0.003475665347650647,
0.009229982271790504,
-0.024597903713583946,
0.019486799836158752,
0.038027528673410416,
-0.0010261144489049911,
-0.0012792178895324469,
0.022498082369565964,
-0.010799079202115536,
-0.03142809122800827,
-0.0028973491862416267,
-0.036181531846523285,
-0.003977545537054539,
0.0011414892505854368,
-0.02669772319495678,
0.02623622491955757,
-0.0026810213457792997,
0.02445945329964161,
0.02231348305940628,
0.04245791956782341,
-0.030043592676520348,
0.011906676925718784,
-0.006224469281733036,
0.0045746099203825,
0.021748146042227745,
-0.019452188163995743,
-0.03458935767412186,
-0.006305231712758541,
0.017133153975009918,
0.007718572858721018,
0.02815144695341587,
-0.001016740221530199,
-0.00882040150463581,
0.015448682941496372,
-0.012275876477360725,
0.008843476884067059,
0.050718754529953,
-0.01881762593984604,
0.005336083471775055,
0.035050857812166214,
0.01754850335419178,
0.01654474437236786,
0.03823520243167877,
0.006974405609071255,
-0.006668662186712027,
-0.016925480216741562,
-0.013095037080347538,
0.014214172959327698,
-0.03784292936325073,
0.0043900106102228165,
0.08366978913545609,
-0.02591317519545555,
-0.003922742325812578,
0.018436890095472336,
0.013971885666251183,
0.006172550842165947,
0.026813099160790443,
0.0032622218132019043,
-0.0048947748728096485,
-0.01826382800936699,
0.016925480216741562,
-0.008295446634292603,
0.025543976575136185,
-0.018217677250504494,
0.02653620019555092,
-0.0028151446022093296,
0.019013764336705208,
0.036735329777002335,
-0.004003504756838083,
-0.0015474642859771848,
-0.003403556067496538,
0.022486545145511627,
-0.001884935423731804,
0.03055124171078205,
-0.017329292371869087,
-0.015979407355189323,
-0.02143663354218006,
-0.006599437445402145,
-0.012437401339411736,
-0.015321770682930946,
0.01900222711265087,
-0.004193873144686222,
0.02027134969830513,
-0.0025988169945776463,
-0.0033660591579973698,
-0.03855825215578079,
0.0020003102254122496,
-0.018333053216338158,
0.007476285565644503,
-0.012575850822031498,
0.0014335316373035312,
0.014041110873222351,
-0.005324546247720718,
0.004136186093091965,
0.004214063752442598,
0.028589870780706406,
-0.014721821993589401,
-0.0005581254954449832,
0.002104147570207715,
-0.03943509981036186,
-0.017167767509818077,
-0.0017349482513964176,
-0.002916097640991211,
-0.018252290785312653,
-0.030205117538571358,
-0.007741647772490978,
0.014848734252154827,
-0.004170798230916262,
0.010868304409086704,
-0.038673628121614456,
-0.022844206541776657,
0.017536966130137444,
0.03135886415839195,
0.018863776698708534,
0.016290919855237007
] | 2025-01-13 | 30 | 39801735 | [
"autologous T cells",
"Allogeneic CAR-T cell therapy",
"monovalent anti-CD3 Abs",
"allogeneic CAR-T cells",
"TCR deletion",
"TCR-positive cells",
"TCR",
"an effective cell therapy",
"advanced hematological tumors",
"costly, large-scale magnetic cell separation",
"the remaining TCR-positive cells",
"genome editing",
"single-chain variable fragment",
"scFv",
"Fab",
"GVHD",
"IgG",
"host",
"CAR-T",
"apoptosis",
"not whole IgG",
"a good alternative",
"an alternative method",
"its timely and universal generation",
"-use",
"the use",
"an obstacle",
"this study",
"we"
] | [
"Allogeneic cells",
"Anti-CD3 antibody",
"Apoptosis",
"Graft-versus-host disease",
"Receptors, chimeric antigen",
"T-lymphocytes"
] | 0 | 10.4110/in.2024.24.e43 | [
"Kim",
"Kim",
"Lee",
"Park",
"Choi"
] | [
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.",
"Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.",
"Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.\nCancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea.\nTicaros Inc., Seoul 04784, Korea.",
"Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Seoul 03080, Korea.\nDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.\nCancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea."
] | [
"39801735",
"29567707",
"36813894",
"37979380",
"29226764",
"29226797",
"37554322",
"22466705",
"26183927",
"28123068",
"28225754",
"29605708",
"33308471",
"36288281",
"8482839",
"11086054",
"37153038",
"26502778",
"23136200",
"23524462",
"32671047",
"37196643",
"1944559",
"8871640",
"24211041",
"10531067",
"26973653",
"10447711",
"10653388",
"10438914"
] | [] | 8.272791 | 3.390259 |
39800376 | 39 | Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15. | The ability of immune cells to expand numerically after infusion distinguishes adoptive immunotherapies from traditional drugs, providing unique therapeutic advantages as well as the potential for unmanageable toxicities. Here, we describe a case of lethal hyperleukocytosis in a patient with neuroblastoma treated on phase 1 clinical trial (NCT03294954) with autologous natural killer T cells (NKTs) expressing a GD2-specific chimeric antigen receptor and cytokine interleukin 15 (GD2-CAR.15). This patient was the first to be treated on dose level (DL) 5 and the first patient whose product was restimulated with K562-derived artificial antigen-presenting cells (aAPCs) instead of autologous peripheral blood mononuclear cells (PBMCs). 12 previously treated patients on DLs 1 through 4 did not experience significant toxicity. Our root-cause analysis revealed no genetic alterations of known clinical significance and excluded the possibility of clonal expansion due to insertional retroviral mutagenesis. We report that the use of aAPCs instead of PBMCs for CAR-NKT restimulation contributed to a hyperproliferative state associated with distinct gene expression that possibly led to explosive lymphocyte expansion and uncontrolled toxicity in the patient. These findings warrant the implementation of measures to control immune cell activation during manufacture of cell therapy products, especially those armed with transgenic cytokines. | [
0.019580690190196037,
0.008847992867231369,
0.04879993945360184,
0.051861003041267395,
-0.023337451741099358,
-0.020516717806458473,
-0.02470354549586773,
0.020440824329853058,
-0.001392973936162889,
0.016089560464024544,
0.01576068438589573,
-0.0013471212005242705,
-0.04819278419017792,
0.00421844981610775,
0.03134428337216377,
-0.04255132004618645,
0.03797237202525139,
-0.021123871207237244,
-0.025196857750415802,
0.025373945012688637,
0.025804011151194572,
0.03258388862013817,
0.009992729872465134,
0.018062807619571686,
-0.01611485704779625,
-0.02455175668001175,
0.026917126029729843,
-0.023261556401848793,
-0.022085197269916534,
-0.03708694130182266,
0.005439080763608217,
-0.010479717515408993,
0.002254688646644354,
-0.008544416166841984,
-0.02876388281583786,
0.010954055935144424,
0.0750340148806572,
0.03723872825503349,
-0.042146552354097366,
-0.010973028838634491,
0.04902762174606323,
-0.022578509524464607,
-0.0014672869583591819,
0.12122825533151627,
-0.06972142308950424,
-0.006628089118748903,
0.006068369839340448,
-0.051203254610300064,
0.02881447970867157,
-0.01601366512477398,
-0.0031812298111617565,
0.020263738930225372,
-0.0163678377866745,
0.03159726411104202,
-0.0604623407125473,
0.05499796196818352,
0.0018910293001681566,
0.021629832684993744,
-0.01257945504039526,
0.002469722181558609,
0.03359581157565117,
-0.041235823184251785,
0.05016603320837021,
-0.026512356474995613,
-0.03754230588674545,
-0.05026722699403763,
-0.04639662429690361,
-0.011801539920270443,
0.016582872718572617,
0.05965280160307884,
0.01896088942885399,
-0.012237931601703167,
-0.04338615760207176,
-0.0060272603295743465,
0.02057996392250061,
0.02876388281583786,
0.0008067706367000937,
0.019530095160007477,
-0.000240331472014077,
-0.04290549457073212,
0.03885780647397041,
0.00937925186008215,
-0.011801539920270443,
-0.023261556401848793,
0.0030152113176882267,
-0.035088393837213516,
0.04265251383185387,
-0.052721135318279266,
-0.039313171058893204,
-0.005777442362159491,
-0.005910256877541542,
-0.015140882693231106,
-0.03394998237490654,
0.050798483192920685,
-0.03817475587129593,
0.044145096093416214,
0.013407966122031212,
-0.026765337213873863,
0.037947073578834534,
0.015823930501937866,
0.040578071027994156,
0.02007400244474411,
-0.007462924811989069,
-0.01265534944832325,
0.02372957020998001,
0.028080835938453674,
-0.041337013244628906,
0.04454986751079559,
0.034835413098335266,
-0.01930241286754608,
0.06375108659267426,
-0.0022641755640506744,
-0.008879615925252438,
0.039920322597026825,
-0.01778452843427658,
-0.05813492089509964,
-0.06273916363716125,
-0.018632013350725174,
0.010384849272668362,
0.019504796713590622,
-0.027068912982940674,
0.022325528785586357,
0.026006394997239113,
-0.026411164551973343,
-0.019024133682250977,
-0.012889356352388859,
0.062233202159404755,
0.011441043578088284,
-0.013534456491470337,
-0.051000870764255524,
0.05021663010120392,
-0.008304084651172161,
0.015039690770208836,
-0.024425268173217773,
-0.07771561294794083,
-0.008120673708617687,
-0.019656585529446602,
-0.007323785685002804,
-0.013825383968651295,
-0.006919016595929861,
0.004955255426466465,
-0.016759958118200302,
-0.02012459933757782,
0.005559246521443129,
-0.0483698733150959,
0.010448094457387924,
0.0017692823894321918,
0.046927884221076965,
0.015292671509087086,
0.05413782596588135,
-0.030256468802690506,
0.07159347832202911,
0.04050217941403389,
-0.008930211886763573,
0.010226736776530743,
-0.039566151797771454,
0.015482407063245773,
0.05600988119840622,
-0.008847992867231369,
-0.0468519888818264,
-0.004670652560889721,
0.011687698774039745,
-0.007481898181140423,
-0.02389400824904442,
-0.03238150477409363,
0.02211049571633339,
-0.006422542501240969,
0.016431083902716637,
-0.06071532145142555,
0.0073996796272695065,
0.00818391889333725,
-0.02901686355471611,
-0.06719162315130234,
-0.012250580824911594,
-0.07058156281709671,
-0.00836100522428751,
0.002558265347033739,
0.02017519436776638,
-0.03572084754705429,
-0.01662081852555275,
0.0277013648301363,
-0.01428074948489666,
0.021326256915926933,
-0.02465295046567917,
-0.0659773126244545,
0.010599883273243904,
-0.006988586392253637,
0.016140155494213104,
-0.03736522048711777,
-0.017152078449726105,
0.05026722699403763,
-0.044600460678339005,
0.03018057346343994,
-0.008784747682511806,
0.0192644651979208,
-0.045258212834596634,
0.03776998817920685,
0.00618853559717536,
-0.02520950697362423,
-0.03344402089715004,
0.03068653494119644,
-0.026082290336489677,
-0.03797237202525139,
-0.04361383989453316,
-0.0006514248088933527,
-0.018518172204494476,
-0.006539545953273773,
0.03248269483447075,
-0.006843122653663158,
-0.010410147719085217,
0.053075309842824936,
0.00637827068567276,
-0.02470354549586773,
0.046776093542575836,
-0.01196597795933485,
-0.017771881073713303,
-0.01793631725013256,
0.04186827316880226,
0.01951744593679905,
0.008797396905720234,
0.010473392903804779,
-0.009417199529707432,
-0.04730735346674919,
0.016848500818014145,
-0.045814767479896545,
-0.00955633819103241,
0.01891029253602028,
-0.01057458482682705,
-0.011795216239988804,
-0.0022436208091676235,
-0.019896917045116425,
0.02002340741455555,
0.024981824681162834,
-0.07321255654096603,
-0.028182027861475945,
0.009157894179224968,
0.025981096550822258,
0.030762428417801857,
0.06253677606582642,
-0.013787437230348587,
0.04110933095216751,
0.030635938048362732,
0.013230879791080952,
0.0010166653664782643,
-0.027574874460697174,
-0.0066976589150726795,
-0.003351991530507803,
-0.06820354610681534,
0.013660946860909462,
0.000522167538292706,
-0.04303198307752609,
-0.0047117616049945354,
0.005451729986816645,
-0.03308985009789467,
-0.021971356123685837,
-0.0016601845854893327,
0.03771939128637314,
-0.023084471002221107,
-0.02135155349969864,
-0.01855611987411976,
0.04245012626051903,
-0.023615729063749313,
-0.02211049571633339,
-0.03430415689945221,
-0.0548967681825161,
0.016848500818014145,
0.017721284180879593,
0.02362837828695774,
-0.0052746436558663845,
0.013028495945036411,
0.030661236494779587,
-0.0322297140955925,
0.015823930501937866,
-0.03210322558879852,
-0.05606047809123993,
0.0028507739771157503,
0.007336434442549944,
0.019998108968138695,
-0.015027041547000408,
-0.010878161527216434,
-0.020769698545336723,
0.00014852722233626992,
0.00047394316061399877,
-0.06759639084339142,
-0.009923160076141357,
0.011415745131671429,
0.005243021063506603,
0.002713215770199895,
-0.039313171058893204,
-0.05828670784831047,
-0.004534675274044275,
0.0015163018833845854,
0.020301684737205505,
-0.013382668606936932,
0.005951366387307644,
0.018328437581658363,
-0.030003488063812256,
0.027068912982940674,
-0.02871328592300415,
0.01610220968723297,
-0.03647978976368904,
0.028586797416210175,
-0.01072637364268303,
-0.040729861706495285,
-0.00945514626801014,
0.01844227872788906,
0.013989822007715702,
-0.006615439895540476,
0.01834108680486679,
0.04209595546126366,
0.009727099910378456,
-0.001783512532711029,
0.010289981961250305,
0.02699301950633526,
0.014331345446407795,
0.003487968584522605,
0.015634194016456604,
-0.04513172060251236,
0.008980807848274708,
-0.004351264797151089,
-0.052164580672979355,
-0.03804826736450195,
-0.02170572616159916,
-0.012237931601703167,
0.020921487361192703,
-0.01194700412452221,
0.02942163310945034,
-0.005834362935274839,
0.05057080090045929,
-0.0277013648301363,
0.0033678028266876936,
-0.046776093542575836,
0.041337013244628906,
-0.011213360354304314,
0.01901148445904255,
-0.03410177305340767,
-0.009429847821593285,
-0.05722418799996376,
0.024475863203406334,
-0.02180691994726658,
-0.011934354901313782,
0.03501250222325325,
-0.021579235792160034,
-0.00027313988539390266,
-0.004781331401318312,
0.013559754937887192,
0.015178830362856388,
0.01997281052172184,
0.005189262330532074,
0.034228261560201645,
-0.004253234714269638,
0.0010166653664782643,
-0.005192424636334181,
0.06526897102594376,
0.0013834871351718903,
-0.0070012351498007774,
-0.0002893464406952262,
-0.01065047923475504,
0.021629832684993744,
0.0304841510951519,
-0.021060626953840256,
0.03878191113471985,
-0.019542744383215904,
0.035771444439888,
0.020820295438170433,
0.040729861706495285,
-0.04619424045085907,
0.05671822652220726,
-0.06319452822208405,
-0.022452019155025482,
-0.019504796713590622,
0.013205582275986671,
0.03675806522369385,
0.03286216780543327,
-0.04976126551628113,
0.02536129578948021,
0.03640389442443848,
-0.004082472994923592,
0.017291218042373657,
0.022388774901628494,
0.04664960503578186,
0.005499163642525673,
-0.0011945422738790512,
-0.03933846950531006,
-0.02327420562505722,
0.03248269483447075,
0.008449548855423927,
-0.013382668606936932,
-0.08656992763280869,
0.020213142037391663,
0.017164727672934532,
-0.030939515680074692,
-0.008373654447495937,
-0.008247164078056812,
-0.01581128127872944,
0.046371325850486755,
-0.04040098562836647,
0.07720965147018433,
0.05636405572295189,
0.032507993280887604,
-0.03675806522369385,
-0.015874525532126427,
-0.029345737770199776,
-0.041842974722385406,
0.03868071734905243,
-0.03736522048711777,
0.028182027861475945,
0.015153531916439533,
0.03369700163602829,
-0.024931227788329124,
-0.003440534695982933,
-0.0004241376300342381,
0.028687989339232445,
-0.007298487238585949,
0.03567025065422058,
-0.025601627305150032,
-0.03233090788125992,
0.05955161154270172,
-0.021161818876862526,
0.05621226876974106,
0.00930335745215416,
-0.05950101464986801,
-0.01541916187852621,
-0.04303198307752609,
-0.01471081655472517,
-0.025639573112130165,
0.03303925320506096,
0.011542235501110554,
0.01840433105826378,
-0.020289035513997078,
-0.02495652623474598,
0.05499796196818352,
-0.003617621259763837,
-0.04644722118973732,
-0.00055892881937325,
0.05773014947772026,
-0.04925530403852463,
0.03789648041129112,
-0.040780454874038696,
0.022502616047859192,
-0.012035547755658627,
0.006843122653663158,
-0.030711833387613297,
-0.006590141914784908,
0.03703634440898895,
0.007855044677853584,
-0.010093921795487404,
-0.010966705158352852,
-0.001470449147745967,
0.007551467977464199,
-0.001186636625789106,
-0.020466122776269913,
0.01946684904396534,
0.0031100790947675705,
-0.029295142740011215,
-0.03023117035627365,
0.016582872718572617,
-0.05747716873884201,
0.010100246407091618,
0.024071095511317253,
0.025626923888921738,
-0.00733010983094573,
-0.020807646214962006,
-0.026967721059918404,
-0.011194387450814247,
0.015292671509087086,
0.019643936306238174,
-0.02571546845138073,
0.023135066032409668,
-0.019783075898885727,
0.002268918789923191,
-0.03228031098842621,
-0.006058882921934128,
-0.0038168432656675577,
-0.014976445585489273,
0.06020935997366905,
0.035240184515714645,
0.00696328841149807,
0.02871328592300415,
0.02815672941505909,
0.006982261780649424,
-0.004778169095516205,
-0.004977391567081213,
-0.035138990730047226,
0.05828670784831047,
0.026613548398017883,
-0.010245710611343384,
0.0017439842922613025,
-0.010549287311732769,
0.00749454740434885,
0.005366348661482334,
0.013294124975800514,
0.041589993983507156,
-0.013395317830145359,
-0.027473682537674904,
0.019125325605273247,
0.035290781408548355,
-0.04756033420562744,
-0.029143353924155235,
-0.005043798591941595,
-0.013003197498619556,
-0.006381432991474867,
0.02083294466137886,
0.007753852289170027,
0.05914684012532234,
0.003937009256333113,
0.007222593296319246,
0.03164786100387573,
-0.01820194721221924,
0.014723464846611023,
-0.04270310699939728,
0.022388774901628494,
0.007336434442549944,
-0.02566487155854702,
-0.034531839191913605,
-0.0390348918735981,
-0.04890112951397896,
-0.010093921795487404,
-0.019934862852096558,
0.002289473544806242,
-0.03617621213197708,
-0.026107586920261383,
-0.03847833350300789,
0.017468303442001343,
0.025829309597611427,
-0.019441550597548485,
-0.02921924740076065,
-0.03286216780543327,
-0.019542744383215904,
-0.04196946322917938,
0.026765337213873863,
-0.009056702256202698,
0.02423553168773651,
0.018783802166581154,
-0.03192614018917084,
-0.020213142037391663,
-0.012282202951610088,
0.010359551757574081,
-0.014938498847186565,
-0.004683301318436861,
0.006005124654620886,
0.008354680612683296,
0.04270310699939728,
-0.010302631184458733,
0.024918578565120697,
-0.0017550522461533546,
0.023299504071474075,
-0.013066442683339119,
0.0011668725637719035,
0.0035417270846664906,
0.0367833636701107,
-0.021263010799884796,
0.021111221984028816,
0.007817097008228302,
-0.004490403924137354,
0.017885722219944,
-0.022654403001070023,
-0.019833670929074287,
-0.00474970880895853,
0.004269045777618885,
-0.023261556401848793,
-0.021528640761971474,
0.006302376743406057,
-0.03144547715783119,
-0.034380048513412476,
-0.018872344866394997,
-0.0037852206733077765,
0.0019115839386358857,
-0.01367359608411789,
0.04146350547671318,
-0.05580749735236168,
0.015368564985692501,
-0.006432029418647289,
-0.004790818318724632,
0.034127067774534225,
-0.018922941759228706,
0.002129779662936926,
0.0206432081758976,
-0.0018435954116284847,
-0.01524207554757595,
-0.022793542593717575,
-0.029244545847177505,
-0.03169845789670944,
0.041185226291418076,
-0.019428903236985207,
0.005730008240789175,
-0.026613548398017883,
0.0022562697995454073,
-0.013407966122031212,
0.01455902773886919,
0.0038642771542072296,
-0.007026533596217632,
0.053378887474536896,
0.020061353221535683,
-0.01815135031938553,
0.014875253662467003,
0.02175632305443287,
-0.034987203776836395,
-0.0019100027857348323,
-0.010992002673447132,
-0.00001221050933963852,
-0.004797142930328846,
-0.01682320237159729,
-0.03761820122599602,
-0.004730735439807177,
0.045966558158397675,
0.025981096550822258,
-0.011959653347730637,
0.012604753486812115,
0.00851279404014349,
0.05530153587460518,
0.016494328156113625,
-0.03291276469826698,
-0.010612531565129757,
0.005556084215641022,
-0.0027290270663797855,
0.0012712270254269242,
-0.0036334325559437275,
0.02128830924630165,
-0.04070456326007843,
-0.00750719616189599,
0.009840941056609154,
-0.000581459840759635,
-0.015469757840037346,
0.007665309123694897,
-0.03716283664107323,
-0.004373400472104549,
-0.007178321480751038,
-0.006602791137993336,
-0.0014823076780885458,
-0.003114822320640087,
-0.03706164285540581,
-0.007298487238585949,
0.031243091449141502,
0.001260159071534872,
-0.04513172060251236,
0.017594793811440468,
-0.022236986085772514,
-0.015317969024181366,
0.007855044677853584,
-0.022274933755397797,
0.009366602636873722,
-0.002194605767726898,
-0.03668217360973358,
0.03660627827048302,
0.002449167426675558,
-0.03711223974823952,
-0.03308985009789467,
0.038402438163757324,
-0.012566806748509407,
-0.00019190942111890763,
-0.04095754399895668,
0.01092875748872757,
-0.013180283829569817,
0.002893464406952262,
-0.017291218042373657,
0.0015249981079250574,
-0.012946276925504208,
0.04723145812749863,
0.0811055451631546,
-0.015305320732295513,
-0.021326256915926933,
-0.01966923475265503,
0.00980931892991066,
0.011403095908463001,
0.011915381997823715,
0.017771881073713303,
0.004373400472104549,
0.011554884724318981,
0.007633686531335115,
0.07528699934482574,
0.005211398471146822,
-0.00007752468809485435,
-0.01463492214679718,
-0.010081272572278976,
-0.015608896501362324,
-0.003073713043704629,
-0.008139647543430328,
-0.011959653347730637,
-0.006182210985571146,
0.0074376268312335014,
-0.010106571018695831,
-0.038908399641513824,
-0.05052020773291588,
0.017152078449726105,
0.01204819604754448,
0.03703634440898895,
-0.001197704579681158,
0.008987132459878922,
-0.007658984512090683,
-0.012598428875207901,
-0.024779440835118294,
-0.022995928302407265,
-0.015204127877950668,
0.01579863205552101,
0.018277840688824654,
0.005954528693109751,
-0.0025029259268194437,
-0.022173739969730377,
-0.01906208135187626,
0.010037001222372055,
0.018783802166581154,
0.009796669706702232,
-0.0030057246331125498,
0.00792461447417736,
-0.0007103218231350183,
-0.0191506240516901,
-0.02195870690047741,
0.016329891979694366,
0.02189546264708042,
0.007298487238585949,
0.0006735606002621353,
-0.003174905199557543,
-0.0005533948424272239,
-0.02526010386645794,
0.009587961249053478,
-0.007469249423593283,
0.014242801815271378,
0.0076842824928462505,
0.040223900228738785,
0.005752143915742636,
0.014521081000566483,
0.030762428417801857,
-0.004522026516497135,
0.029446929693222046,
0.02932043932378292,
-0.015128234401345253,
0.061980221420526505,
0.00034962696372531354,
-0.02453910931944847,
-0.00004819970126845874,
-0.015001744031906128,
-0.01818929798901081,
-0.013812735676765442,
-0.03334283083677292,
0.035290781408548355,
-0.018480226397514343,
-0.011491639539599419,
-0.018834399059414864,
0.007285838481038809,
0.033469319343566895,
-0.025753414258360863,
-0.02744838409125805,
0.04589066281914711,
-0.004405023064464331,
0.014521081000566483,
0.011377798393368721,
-0.006014611572027206,
-0.009063026867806911,
-0.011934354901313782,
-0.019909566268324852,
0.010220412164926529,
-0.0229200329631567,
-0.00005617945862468332,
-0.003567025065422058,
-0.021225063130259514,
-0.009714451618492603,
0.005805902648717165,
-0.005862823221832514,
-0.03761820122599602,
-0.014799359254539013,
-0.01667141541838646,
0.017114130780100822,
0.0070897783152759075,
0.03023117035627365,
-0.008658257313072681,
-0.005546597298234701,
0.0009202165529131889,
-0.01930241286754608,
0.02113652043044567,
-0.006460489705204964,
-0.018783802166581154,
0.027321893721818924,
-0.029649315401911736,
-0.00715302349999547,
-0.005065934732556343,
-0.02830851823091507,
-0.03147077560424805,
0.02251526527106762,
0.030863620340824127,
-0.015393863432109356,
0.010511339642107487,
0.007304811850190163,
0.00550232594832778,
-0.014546378515660763,
-0.038655418902635574,
-0.00042611404205672443,
0.014015119522809982,
-0.025955799967050552,
-0.035695549100637436,
-0.009271735325455666,
0.03334283083677292,
-0.025171559303998947,
0.04060336947441101,
-0.005913419183343649,
0.05363186448812485,
0.014609623700380325,
-0.10230531543493271,
-0.035999126732349396,
-0.039819132536649704,
0.004142555873841047,
-0.028384411707520485,
0.005122855305671692,
-0.04447397217154503,
-0.016848500818014145,
0.00955633819103241,
-0.029497526586055756,
0.01293362770229578,
-0.0221610926091671,
0.012788164429366589,
0.0007000445039011538,
0.007640011142939329,
-0.0030547394417226315,
-0.007709580939263105,
-0.029143353924155235,
-0.013534456491470337,
0.017468303442001343,
-0.02886507473886013,
0.005163964349776506,
-0.01534326747059822,
0.045814767479896545,
0.0011692442931234837,
-0.009866239503026009,
-0.016595520079135895,
-0.020339632406830788,
-0.015355916693806648,
-0.013256178237497807,
0.016001015901565552,
-0.0024270317517220974,
-0.01889764331281185,
0.023463942110538483,
-0.019390955567359924,
-0.04035038873553276,
0.026284674182534218,
-0.014799359254539013,
-0.004455619025975466,
-0.003573349677026272,
0.0110236257314682,
0.025652222335338593,
0.025930501520633698,
0.004556811414659023,
-0.011795216239988804,
0.00714037474244833,
-0.034784819930791855,
0.021174468100070953,
0.02460235357284546,
0.0007791008683852851,
0.04366443306207657,
-0.030863620340824127,
-0.03873131424188614,
-0.013268827460706234,
-0.025475136935710907,
0.012212634086608887,
-0.025032419711351395,
0.029193948954343796,
0.012604753486812115,
0.01840433105826378,
-0.0005324449157342315,
0.04664960503578186,
0.024071095511317253,
-0.007235242519527674,
-0.011864785104990005,
-0.012029223144054413,
-0.0006569587276317179,
0.027524277567863464,
-0.010252035222947598,
0.00560035603120923,
-0.001952693215571344,
0.020289035513997078,
-0.045814767479896545,
0.013939226046204567,
-0.019378306344151497,
0.006406730972230434,
-0.012174686416983604,
0.012712270021438599,
0.0066217645071446896,
0.019353007897734642,
-0.01265534944832325,
-0.03083832375705242,
-0.034430645406246185,
0.009366602636873722,
-0.015406512655317783,
0.027878452092409134,
0.019745128229260445,
0.0006779087125323713,
-0.004699112847447395,
-0.0038864128291606903,
-0.006220158189535141,
-0.03855422884225845,
-0.019087377935647964,
0.0216551311314106,
-0.0052904547192156315,
-0.010884486138820648,
-0.03918667882680893,
-0.0034658329095691442,
0.008000507950782776,
-0.034784819930791855,
0.04351264610886574,
-0.02113652043044567,
-0.015520353801548481,
-0.004879361484199762,
-0.03202733024954796,
-0.016810555011034012,
0.024931227788329124,
-0.012946276925504208,
0.00569206103682518,
-0.006703983061015606,
0.04862285405397415,
-0.012345448136329651,
0.01445783581584692,
0.0021408475004136562,
0.00798153504729271,
0.02921924740076065,
0.007867693901062012,
-0.015393863432109356,
0.01402776874601841,
-0.01094773132354021,
0.04842046648263931,
0.011403095908463001,
-0.009240113198757172,
0.003034184919670224,
-0.025677520781755447,
0.012187335640192032,
0.008196568116545677,
-0.0013898116303607821,
-0.0032476370688527822,
-0.0020191005896776915,
-0.00637827068567276,
-0.011295579373836517,
0.017594793811440468,
-0.0066597117111086845,
-0.01815135031938553,
0.014495782554149628,
0.02689182758331299,
0.010783294215798378,
-0.033064551651477814,
0.03235620632767677,
0.004582109395414591,
-0.007911965250968933,
0.010055975057184696,
-0.027321893721818924,
0.02179427072405815,
-0.008379979059100151,
-0.024362022057175636,
0.02465295046567917,
0.016494328156113625,
0.02475414238870144,
-0.02144009806215763,
0.005037474445998669,
0.024880632758140564,
0.038706015795469284,
0.03698574751615524,
0.041185226291418076,
0.015988368541002274,
-0.02520950697362423,
-0.05454259738326073,
-0.002830219455063343,
-0.011226009577512741,
0.038807209581136703,
-0.02744838409125805,
-0.030509447678923607,
0.015431810170412064,
-0.020352281630039215,
-0.019188571721315384,
0.010897135362029076,
0.011169089004397392,
-0.001118648098781705,
-0.005021662916988134,
-0.05955161154270172,
0.032457396388053894,
-0.01094773132354021,
-0.018783802166581154,
-0.003037347225472331,
0.008620310574769974,
0.03470892459154129,
0.01904943212866783,
0.04171648621559143,
-0.019251815974712372,
0.00678620208054781,
0.03721342980861664,
-0.010112895630300045,
0.05026722699403763,
-0.014609623700380325,
-0.03265978395938873,
-0.04710496962070465,
0.03129368647933006,
0.016405785456299782,
-0.036707472056150436,
-0.017152078449726105,
0.015570949763059616,
0.03703634440898895,
0.03822535276412964,
-0.03918667882680893,
-0.031066006049513817,
0.01702558808028698,
-0.04776271805167198,
-0.03531607612967491,
-0.012775515206158161,
0.004031876567751169,
0.03311514854431152,
-0.03607501834630966,
0.0031843921169638634,
0.035897932946681976,
0.006716632284224033,
-0.04710496962070465,
-0.009581636637449265,
0.05031782016158104,
0.01194700412452221,
0.05459319055080414,
-0.026158183813095093,
0.021161818876862526,
0.03248269483447075,
0.016443733125925064,
0.005695223342627287,
0.006432029418647289,
-0.021882813423871994,
-0.02160453423857689,
-0.040173303335905075,
-0.04146350547671318,
0.004012903198599815,
-0.0002612814132589847,
-0.00810170080512762,
-0.005698385648429394,
0.010707399807870388,
0.03126838803291321,
0.002292635850608349,
0.030813025310635567,
-0.015608896501362324,
0.02068115584552288,
-0.010745346546173096,
0.017594793811440468,
0.0108275655657053,
-0.012345448136329651,
-0.01596307009458542,
-0.017190024256706238,
0.0021582399494946003,
0.002591469092294574,
0.02199665457010269,
0.0012514629634097219,
-0.0030958489514887333,
-0.026234077289700508,
-0.015722738578915596,
0.004882523790001869,
0.012902005575597286,
-0.0031069167889654636,
-0.041589993983507156,
-0.01016349159181118,
-0.02231287956237793,
-0.03501250222325325,
0.03159726411104202,
0.016279295086860657,
0.03291276469826698,
0.009537365287542343,
0.015254723839461803,
0.026183482259511948,
0.006956963799893856,
0.0026262537576258183,
0.006235969252884388,
0.007696931716054678,
-0.017556846141815186,
-0.026790635660290718,
0.0011763593647629023,
-0.011567533016204834,
0.010909783653914928,
-0.028384411707520485,
0.04029979556798935,
0.030661236494779587,
0.012883031740784645,
-0.003668217221274972,
-0.0299781896173954,
-0.00929703377187252,
-0.007273189257830381,
-0.013180283829569817,
0.023438643664121628,
-0.00472757313400507,
0.015507704578340054,
-0.0007079500937834382,
-0.0021550776436924934,
-0.017139429226517677,
-0.025335997343063354,
-0.013901278376579285,
0.020908838137984276,
0.002948804059997201,
-0.02734719216823578,
-0.02891567163169384,
0.02724600024521351,
0.013357370160520077,
-0.02480473741889,
0.025955799967050552,
-0.012857734225690365,
0.00490465946495533,
-0.012345448136329651,
-0.03642919287085533,
-0.0030405092984437943,
0.016076911240816116,
0.006520572584122419,
-0.02465295046567917,
0.03007938154041767,
0.017923668026924133,
-0.012826111167669296,
-0.013585052452981472,
0.011143791489303112,
-0.0084368996322155,
-0.01576068438589573,
-0.04912881180644035,
0.05960220471024513,
0.011428394354879856,
-0.03420296311378479,
0.013458563014864922,
0.03774468973278999,
-0.019934862852096558,
0.023210961371660233,
0.009980080649256706,
-0.005964015144854784,
0.01616545394062996,
0.01275654137134552,
0.010454419068992138,
-0.02189546264708042,
0.002741676289588213,
0.007380706258118153,
0.018619364127516747,
-0.009840941056609154,
-0.011213360354304314,
0.006179048679769039,
0.006223320495337248,
0.0011115330271422863,
-0.021010030061006546,
0.0463460274040699,
-0.0069316658191382885,
-0.013407966122031212,
-0.005366348661482334,
-0.012857734225690365,
0.020592613145709038,
-0.020352281630039215,
0.0037219757214188576,
0.021022679284214973,
0.005913419183343649,
-0.014179556630551815,
-0.012130415067076683,
0.02455175668001175,
0.0025187372229993343,
-0.007481898181140423,
0.00030041433637961745,
-0.026158183813095093,
-0.011599156074225903,
-0.025652222335338593,
-0.00013834871060680598,
0.0599563792347908,
-0.013370019383728504,
-0.045612383633852005,
0.04391741380095482,
0.02118711732327938,
0.005208236165344715,
0.04014800488948822,
0.010897135362029076,
-0.004284857306629419,
0.030787726864218712,
-0.016342541202902794,
0.029345737770199776,
0.027524277567863464,
0.010195113718509674,
0.031243091449141502,
0.025019772350788116,
-0.026183482259511948,
-0.02266705222427845,
0.005208236165344715,
-0.005701547954231501,
0.03450654074549675,
0.030408255755901337,
-0.04045158252120018,
-0.03612561523914337,
0.0032729352824389935,
0.005894445814192295,
0.04710496962070465,
0.02099738083779812,
0.009954783134162426,
0.04300668463110924,
0.0011787309776991606,
-0.02846030704677105,
0.013698894530534744,
-0.011010976508259773,
0.007918289862573147,
-0.019024133682250977,
-0.021478043869137764,
-0.03233090788125992,
0.012902005575597286,
0.0035607004538178444,
-0.01059355866163969,
-0.006849447265267372,
0.010176140815019608,
0.0117129972204566,
-0.03911078721284866,
0.010568260215222836,
-0.0024570731911808252,
0.003064226359128952,
-0.009164218790829182,
-0.014799359254539013,
-0.016646116971969604,
-0.009613258764147758,
0.017443004995584488,
0.007469249423593283,
0.03018057346343994,
0.005021662916988134,
0.005230371840298176,
0.011548560112714767,
-0.001026152167469263,
0.005113368388265371,
-0.03708694130182266,
-0.0005209817318245769,
-0.045106422156095505,
-0.017114130780100822,
-0.009233788587152958,
0.012370746582746506,
0.00706448033452034,
0.0055086505599319935,
-0.009802994318306446,
0.0049141463823616505,
0.010176140815019608,
-0.0011281348997727036,
0.00784872006624937,
0.002194605767726898,
-0.031015409156680107,
0.011896408163011074,
0.001830946421250701,
0.010859187692403793,
-0.027979644015431404,
0.03999621793627739,
0.005024825222790241,
0.002993075642734766,
0.03885780647397041,
-0.02276824414730072,
-0.026613548398017883,
-0.007235242519527674,
-0.00896815862506628,
0.020858243107795715,
-0.044651057571172714,
0.005568733438849449,
-0.0009534202399663627,
0.0048382519744336605,
0.025095665827393532,
0.006956963799893856,
0.011352499946951866,
-0.03248269483447075,
-0.005717359483242035,
-0.016190752387046814,
0.02133890613913536,
0.02434937283396721,
0.022338178008794785,
0.041640590876340866,
-0.004866712260991335,
0.007962561212480068,
-0.010372200980782509,
-0.0014649152290076017,
-0.019024133682250977,
0.00800683256238699,
0.004095121752470732,
0.01778452843427658,
-0.039819132536649704,
-0.008797396905720234,
0.007570441346615553,
0.01280713826417923,
0.011422069743275642,
0.013648297637701035,
-0.02800494059920311,
0.005986151285469532,
-0.019125325605273247,
0.0015336943324655294,
-0.003924360033124685,
0.03058534301817417,
0.005167126655578613,
0.015292671509087086,
0.02977580577135086,
-0.01586187817156315,
0.03531607612967491,
0.005533948540687561,
0.002703729085624218,
-0.0031401205342262983,
-0.020390227437019348,
0.012370746582746506,
-0.02541189081966877,
-0.017645390704274178,
0.017544196918606758,
0.020402876660227776,
-0.01349650975316763,
-0.04842046648263931,
0.04399330914020538,
0.013888629153370857,
-0.0023622054141014814,
-0.010302631184458733,
-0.02002340741455555,
0.018771152943372726,
0.0017424032557755709,
0.00429434422403574,
-0.0005771117866970599,
-0.029396334663033485,
-0.010391173884272575,
0.002289473544806242,
-0.01230117678642273,
0.0026894989423453808,
-0.012111441232264042,
-0.01118173822760582,
0.0019384630722925067,
-0.012155713513493538,
-0.01717737689614296,
-0.06916487216949463,
-0.015406512655317783,
0.012528859078884125,
-0.027043616399168968,
-0.010327928699553013,
-0.006558519322425127,
0.020794996991753578,
0.02714480832219124,
-0.039414361119270325,
0.005865985527634621,
0.020706454291939735,
0.024159638211131096,
0.008329383097589016,
0.00043006683699786663,
0.019694531336426735,
0.030357660725712776,
-0.0435885414481163,
-0.017708634957671165,
-0.011428394354879856,
0.006403569132089615,
0.047383248805999756,
-0.03739051893353462,
0.01655757427215576,
0.0289662666618824,
-0.02104797773063183,
0.024222882464528084,
-0.01092875748872757,
-0.030307063832879066,
0.023438643664121628,
0.009682828560471535,
-0.0182525422424078,
-0.04771212115883827,
-0.014584326185286045,
-0.01206716988235712,
0.024981824681162834,
0.025196857750415802,
-0.017974264919757843,
0.01707618311047554,
0.007557792589068413,
0.013711542822420597,
-0.0055750575847923756,
-0.0011368311243131757,
-0.0011352499714121222,
0.03164786100387573,
-0.0029472229070961475,
-0.018632013350725174,
0.00037037927540950477,
-0.000272942241281271,
-0.0035164288710802794,
-0.009929484687745571,
0.00009467004565522075,
-0.03584733605384827,
-0.008645609021186829,
-0.003848465858027339,
-0.003481644205749035,
-0.0051481532864272594,
0.018872344866394997,
-0.009568987414240837,
-0.011592831462621689,
-0.004398698452860117,
-0.012010249309241772,
-0.052215173840522766,
-0.01044176984578371,
0.007532494608312845,
-0.018682610243558884,
-0.012623727321624756,
-0.019327709451317787,
-0.01506498921662569,
-0.008032131008803844,
-0.012522534467279911,
0.024045797064900398,
-0.01885969564318657,
0.013888629153370857,
-0.005872309673577547,
-0.00927805993705988,
0.0038990620523691177,
-0.0002830219455063343,
-0.02739778906106949,
-0.019846320152282715,
-0.040780454874038696,
-0.006428867112845182,
0.015254723839461803,
-0.030205871909856796,
-0.03776998817920685,
0.006235969252884388,
-0.005075421184301376,
-0.01707618311047554,
0.011485314927995205,
0.015735387802124023,
-0.009537365287542343,
0.008999781683087349,
-0.02972520887851715,
0.02093413658440113,
-0.005540273152291775,
0.017215322703123093,
0.00815862137824297,
-0.009916835464537144,
0.012003924697637558,
-0.03268508240580559,
-0.015495055355131626,
-0.017569495365023613,
-0.018821749836206436,
-0.0006411474314518273,
-0.025753414258360863,
0.003892737440764904,
-0.0027796232607215643,
0.029092757031321526,
-0.003345667151734233,
0.02982640080153942,
-0.0234259944409132,
-0.008721502497792244,
0.032255012542009354,
-0.005442243069410324,
0.022072548046708107,
0.05469438433647156,
-0.01090345997363329,
0.02007400244474411,
0.02805553749203682,
0.017860423773527145,
-0.005932392552495003,
0.0029266681522130966,
0.012193660251796246,
-0.00945514626801014,
-0.03185024484992027,
0.015937771648168564,
0.029244545847177505,
-0.03776998817920685,
-0.004844576586037874,
-0.018530821427702904,
-0.015178830362856388,
0.001263321377336979,
-0.04973596706986427,
0.013003197498619556,
-0.030458852648735046,
0.012902005575597286,
-0.00876577477902174,
0.010315279476344585,
-0.0317237563431263,
0.04391741380095482,
-0.014495782554149628,
-0.0015273697208613157,
0.035594355314970016,
-0.010138193145394325,
-0.018176648765802383,
0.01621605083346367,
0.01473611406981945,
0.022831490263342857,
0.01773393340408802,
0.04095754399895668,
0.003981280606240034,
0.01481200847774744,
-0.04371502995491028,
-0.006488949991762638,
0.022249635308980942,
-0.010277332738041878,
-0.001044335076585412,
0.027574874460697174,
-0.00929703377187252,
0.004278532695025206,
0.0074502755887806416,
0.00955633819103241,
-0.025146260857582092,
0.0282073263078928,
-0.0277013648301363,
0.006368784233927727,
-0.02805553749203682,
-0.025955799967050552,
0.11768653243780136,
-0.007715905085206032,
0.027372490614652634,
-0.0012324893614277244,
-0.0005356071633286774,
-0.014091013930737972,
0.025184208527207375,
0.009113622829318047,
0.00911994744092226,
-0.01987161859869957,
0.025778712704777718,
0.039768535643815994,
0.053075309842824936,
0.030990110710263252,
0.03253329172730446,
-0.02785315364599228,
-0.020061353221535683,
0.025677520781755447,
-0.016987640410661697,
-0.030382957309484482,
-0.0003678099310491234,
0.02434937283396721,
-0.012566806748509407,
0.0001511953742010519,
-0.018214596435427666,
-0.01783512532711029,
-0.03187554329633713,
-0.0015226263785734773,
-0.03506309911608696,
0.00603358494117856,
0.0282073263078928,
0.029193948954343796,
0.02149069309234619,
-0.03974323719739914,
0.005103881470859051,
-0.00939822569489479,
-0.02389400824904442,
-0.022932682186365128,
0.028991565108299255,
-0.008266137912869453,
-0.0011826838599517941,
-0.01645638234913349,
-0.004635867662727833,
0.01265534944832325,
0.01641843467950821,
-0.011036274023354053,
-0.00991051085293293,
-0.002061791019514203,
0.0187585037201643,
-0.022249635308980942,
-0.013192933052778244,
-0.01569744013249874,
0.03556905686855316,
-0.04024919867515564,
-0.013698894530534744,
-0.027372490614652634,
-0.002381179016083479,
0.0028381249867379665,
-0.025690170004963875,
-0.03655568137764931,
-0.013736841268837452,
0.02317301370203495,
0.015672141686081886,
-0.00947412010282278,
0.00439553614705801
] | 2025-01-13 | 1 | 39800376 | [
"cell therapy products",
"immune cells",
"immune cell activation",
"autologous natural killer T cells",
"autologous peripheral blood mononuclear cells",
"known clinical significance",
"clonal expansion",
"lymphocyte expansion",
"unique therapeutic advantages",
"distinct gene expression",
"unmanageable toxicities",
"significant toxicity",
"traditional drugs",
"adoptive immunotherapies",
"insertional retroviral mutagenesis",
"lethal hyperleukocytosis",
"toxicity",
"K562-derived artificial antigen-presenting cells",
"dose level",
"PBMCs",
"transgenic cytokines",
"first",
"measures",
"infusion",
"neuroblastoma",
"phase",
"the first patient",
"NCT03294954",
"NKTs",
"K562"
] | [
"Adoptive cell therapy - ACT",
"Chimeric antigen receptor - CAR",
"Neuroblastoma"
] | 0 | 10.1136/jitc-2024-010156 | [
"Tian",
"Courtney",
"Yu",
"Bhar",
"Xu",
"Barragán",
"Martinez Amador",
"Ghatwai",
"Wood",
"Schady",
"Montalbano",
"Reddy",
"Roche",
"de la Cerda",
"Parsons",
"Di Pierro",
"Bushman",
"Heczey",
"Metelitsa"
] | [
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.\nDepartment of Pediatric Critical Care Medicine, Baylor College of Medicine, Houston, Texas, USA.\nDepartment of Pediatrics-Hematology & Oncology, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.",
"Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Department of Pediatrics-Hematology & Oncology, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.",
"Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.",
"Center for Advanced Innate Cell Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA [email protected].\nCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA."
] | [
"39800376"
] | [] | 11.293136 | 5.889207 |
39798497 | 40 | Optimizing CAR-T cell function in solid tumor microenvironment: insights from culture media additives. | Cancer remains one of the most pressing health challenges worldwide. Recently, chimeric antigen receptor (CAR)-T cell therapy has emerged as a promising approach for treating hematological cancers. However, the translation of CAR-T cell therapy to solid tumors faces formidable obstacles, notably the immunosuppressive tumor microenvironment. Within solid tumors, CAR-T cells encounter a hostile milieu that promotes exhaustion and diminishes their long-term effectiveness against cancer cells. Optimizing the manufacturing process is paramount to ensuring the efficacy of CAR-T cell therapy in solid tumors. A critical aspect of this optimization lies in refining the composition of cell culture media. By supplementing basic culture media with specific additives, researchers aim to improve the behavior and functionality of CAR-T cells, thereby enhancing their therapeutic potential. This review delves into the culture media additives that have been investigated or show promise in modulating CAR-T cell phenotypes and enhancing their anti-tumor efficacy. We explore various types of additives and their mechanisms of action to mitigate exhaustion and augment persistence within the challenging solid tumor microenvironment. By shedding light on the latest advancements in culture media optimization for CAR-T cell therapy, this review aims to provide insights into novel strategies for overcoming the hurdles posed by solid tumors. Ultimately, these insights hold the potential to enhance the effectiveness of CAR-T cell therapy and improve outcomes for cancer patients. | [
0.021029463037848473,
0.010762004181742668,
0.025469141080975533,
0.03790023922920227,
-0.013723663054406643,
-0.05071348696947098,
0.039293959736824036,
0.03785528242588043,
-0.003211741801351309,
-0.019984170794487,
-0.015308459289371967,
-0.027110135182738304,
-0.05858127027750015,
-0.018567970022559166,
0.001937441760674119,
-0.028413940221071243,
0.04940968379378319,
-0.00006111582479206845,
0.02733493037521839,
0.01979309692978859,
0.0008619438158348203,
0.002941989339888096,
0.017500199377536774,
0.007440675515681505,
-0.05489465221762657,
-0.0006497946451418102,
-0.004956704098731279,
0.0414070226252079,
-0.03347180038690567,
-0.03945131599903107,
-0.013285315595567226,
-0.025086991488933563,
-0.03643907979130745,
-0.02291773073375225,
-0.010863161645829678,
0.04419446736574173,
0.047791168093681335,
-0.01321787666529417,
0.005617036018520594,
-0.007249601185321808,
0.03868701681494713,
0.03257262706756592,
0.03821495175361633,
0.10070763528347015,
-0.031111465767025948,
-0.011520683765411377,
0.015488294884562492,
-0.05736738443374634,
0.02313128486275673,
0.02367079071700573,
-0.05102819949388504,
0.02771707996726036,
0.0022535580210387707,
-0.004108107183128595,
-0.022074753418564796,
0.017859870567917824,
-0.03915908560156822,
-0.0000022665979031444294,
-0.004318851511925459,
0.02978518232703209,
0.012150106020271778,
0.004670091904699802,
0.04579050466418266,
-0.056872837245464325,
-0.05008406564593315,
0.003978850785642862,
-0.06051449850201607,
-0.03457329049706459,
-0.0013031017733737826,
0.03945131599903107,
0.010424814186990261,
-0.03884437307715416,
0.0008022330002859235,
0.0036500897258520126,
0.022108472883701324,
-0.02679542452096939,
0.010194400325417519,
0.01665722206234932,
0.0424860343337059,
-0.034303538501262665,
0.00438628951087594,
-0.02960534766316414,
0.023715749382972717,
-0.026143522933125496,
-0.024659883230924606,
0.013948457315564156,
-0.003419676097109914,
-0.02737988904118538,
-0.03203311935067177,
0.003318518865853548,
-0.014960029162466526,
0.009801010601222515,
-0.02904336340725422,
0.0721588209271431,
-0.008367950096726418,
0.008800677955150604,
0.004391909576952457,
-0.040575284510850906,
0.0283015426248312,
0.03331444412469864,
0.04819579795002937,
-0.0010108697460964322,
-0.04102487489581108,
-0.028751131147146225,
0.0499042309820652,
-0.022423183545470238,
-0.047431498765945435,
-0.05682788044214249,
0.010171920992434025,
-0.00842414889484644,
0.0470268689095974,
-0.038574621081352234,
-0.015555732883512974,
0.042598430067300797,
-0.021411612629890442,
-0.05673796311020851,
-0.007221501786261797,
0.021220536902546883,
0.009486299939453602,
0.04091247543692589,
-0.024997074156999588,
0.00624364847317338,
0.037630487233400345,
-0.04165429621934891,
0.02072599157691002,
-0.05066853016614914,
0.08515190333127975,
-0.03367411717772484,
-0.03922652453184128,
-0.06375152617692947,
0.032078079879283905,
-0.00905357114970684,
0.012318701483309269,
-0.031313780695199966,
-0.041047353297472,
-0.0032426510006189346,
-0.037990156561136246,
0.015803005546331406,
-0.0008661587489768863,
-0.029358074069023132,
0.01739904284477234,
0.007957701571285725,
-0.022108472883701324,
0.0011373162269592285,
-0.024187816306948662,
-0.07607023417949677,
-0.010346136055886745,
0.05066853016614914,
-0.014903830364346504,
0.05305134505033493,
-0.013476390391588211,
0.04994918778538704,
0.042081404477357864,
-0.006912410259246826,
0.01182415522634983,
-0.023963022977113724,
0.004442487843334675,
0.06451582908630371,
-0.026525672525167465,
-0.06231284886598587,
0.017297884449362755,
-0.016544826328754425,
-0.03239279240369797,
-0.04958951845765114,
0.026008645072579384,
-0.007182162720710039,
-0.03315708786249161,
-0.0008352495497092605,
-0.06995584070682526,
-0.023445995524525642,
-0.01939970813691616,
-0.08330859243869781,
-0.048735301941633224,
-0.012993083335459232,
-0.018219539895653725,
0.015510774217545986,
0.007614891044795513,
0.017163008451461792,
-0.02625591866672039,
0.0031836426351219416,
0.020074088126420975,
0.01701689325273037,
0.0119365518912673,
0.005080340430140495,
-0.0011682254262268543,
0.03421362116932869,
-0.023063845932483673,
0.018242018297314644,
-0.018725326284766197,
-0.02789691463112831,
-0.038776934146881104,
-0.028953444212675095,
0.031898245215415955,
0.013274075463414192,
-0.013195397332310677,
0.00026957696536555886,
0.02369326911866665,
0.00988530833274126,
0.016601024195551872,
0.00018299622752238065,
0.02477228082716465,
-0.01833193749189377,
-0.01791606843471527,
-0.008530925959348679,
-0.019343508407473564,
-0.023176243528723717,
-0.048915136605501175,
0.041137270629405975,
-0.004844306968152523,
0.027424847707152367,
0.017680034041404724,
0.022232109680771828,
-0.01829821802675724,
0.04747645556926727,
-0.021186817437410355,
0.009576217271387577,
-0.027132615447044373,
0.05215216800570488,
-0.003992900252342224,
0.004838687367737293,
-0.016690941527485847,
0.002201574621722102,
0.0188489630818367,
0.02364831045269966,
0.007092245388776064,
-0.00006541851325891912,
0.014858871698379517,
-0.026031125336885452,
0.02960534766316414,
-0.03104402683675289,
0.015847964212298393,
-0.008261173032224178,
-0.03803511708974838,
-0.004099677316844463,
-0.042283717542886734,
-0.05282654985785484,
0.011947792023420334,
0.024884676560759544,
0.03603444993495941,
-0.014499202370643616,
0.0013733498053625226,
0.013925977982580662,
0.012689611874520779,
-0.023198723793029785,
-0.02535674348473549,
0.02202979475259781,
-0.03344932198524475,
-0.0884338915348053,
-0.011531922966241837,
-0.017646316438913345,
0.019478384405374527,
-0.0122063048183918,
0.015409616753458977,
0.005029761698096991,
0.03828239068388939,
-0.015960361808538437,
0.03214551880955696,
-0.0369785837829113,
0.010407954454421997,
-0.027222532778978348,
-0.025424182415008545,
0.021130619570612907,
-0.022659217938780785,
-0.06667385250329971,
-0.06024474650621414,
0.032280392944812775,
-0.0033016593661159277,
0.00040006276685744524,
0.02868369221687317,
-0.01071142591536045,
0.03425857797265053,
-0.015162344090640545,
0.020658552646636963,
-0.014768954366445541,
-0.035045359283685684,
0.019287310540676117,
-0.02184996008872986,
0.03544998541474342,
-0.01008200366050005,
0.03715841844677925,
-0.03868701681494713,
0.0012623578077182174,
0.02235574647784233,
-0.015162344090640545,
-0.005563647486269474,
-0.02684038318693638,
0.024345170706510544,
0.031920723617076874,
0.03549494594335556,
-0.03695610538125038,
0.007895883172750473,
-0.0036416600923985243,
-0.01008200366050005,
-0.0013326059561222792,
-0.013262836262583733,
-0.014622838236391544,
-0.012981843203306198,
-0.026907822117209435,
-0.03823743015527725,
0.007508113980293274,
-0.02661558985710144,
-0.005032571963965893,
0.006558360066264868,
-0.03342684358358383,
0.03176336735486984,
0.001079010427929461,
-0.003959181252866983,
-0.03515775501728058,
0.05156770348548889,
0.031358737498521805,
0.04174421355128288,
-0.006687616463750601,
0.05008406564593315,
0.03823743015527725,
-0.008896215818822384,
0.03443841636180878,
0.006884310860186815,
-0.03684370964765549,
-0.0053360434249043465,
-0.026166001334786415,
-0.03201064094901085,
-0.021872440353035927,
-0.04716174677014351,
0.00499604269862175,
0.03416866064071655,
-0.06973104923963547,
0.016005320474505424,
-0.02684038318693638,
0.023760708048939705,
-0.03850718215107918,
-0.0033438082318753004,
-0.057592179626226425,
0.07584543526172638,
-0.011127294972538948,
-0.0011640104930847883,
-0.021389132365584373,
-0.014791433699429035,
-0.031718410551548004,
0.04639744758605957,
0.014296887442469597,
-0.021760042756795883,
0.01883772201836109,
-0.03607941046357155,
0.06586459279060364,
-0.005996375344693661,
-0.031898245215415955,
0.0009757457301020622,
0.013723663054406643,
-0.0016143006505444646,
0.056693002581596375,
0.022794093936681747,
0.018185820430517197,
0.01025621872395277,
0.03830486908555031,
-0.011149774305522442,
0.03149361535906792,
-0.03416866064071655,
-0.03198816254734993,
0.008294892497360706,
-0.02980766072869301,
0.033022213727235794,
-0.014926310628652573,
-0.032100558280944824,
0.04106983169913292,
0.06276243925094604,
0.02369326911866665,
-0.02899840474128723,
0.026503192260861397,
-0.028324022889137268,
-0.02899840474128723,
-0.011071096174418926,
0.005923317279666662,
0.026952780783176422,
-0.009210927411913872,
-0.0576820969581604,
0.03942883759737015,
0.008446628227829933,
0.008693900890648365,
-0.01700565405189991,
-0.024277733638882637,
0.02349095419049263,
-0.006372904870659113,
0.009446960873901844,
0.004313231445848942,
-0.008929935283958912,
0.01852301135659218,
0.046307530254125595,
0.0006389062036760151,
-0.10367491096258163,
-0.010171920992434025,
-0.012273742817342281,
-0.02308632619678974,
0.0014457053039222956,
-0.016320031136274338,
0.0015229781856760383,
0.06177334487438202,
-0.040193136781454086,
0.0558837465941906,
0.046307530254125595,
0.009570597670972347,
0.03832734748721123,
-0.03425857797265053,
-0.03718090057373047,
-0.009109769947826862,
0.041137270629405975,
-0.02904336340725422,
0.05615349858999252,
-0.0017168628983199596,
0.006715715397149324,
-0.00041692229569889605,
0.032617583870887756,
-0.01759011670947075,
0.03544998541474342,
0.031021548435091972,
-0.03250518813729286,
-0.03344932198524475,
-0.013510108925402164,
0.022884011268615723,
-0.028211625292897224,
0.02958286739885807,
0.02776203863322735,
-0.0038074455223977566,
0.025446660816669464,
-0.003526453161612153,
-0.01572432741522789,
0.029335593804717064,
0.03016733191907406,
-0.013577546924352646,
-0.02753724344074726,
-0.06429103761911392,
-0.040238093584775925,
0.06069433316588402,
0.028166666626930237,
-0.025806332007050514,
-0.013071761466562748,
0.0288410484790802,
-0.036528997123241425,
-0.003725957591086626,
-0.004417198710143566,
0.009345803409814835,
-0.05718754976987839,
-0.0012026469921693206,
0.024682361632585526,
-0.027492284774780273,
0.02994253858923912,
0.03239279240369797,
0.005161828361451626,
0.04716174677014351,
-0.018995078280568123,
-0.03648403659462929,
-0.014791433699429035,
-0.013757382519543171,
-0.004774058703333139,
0.014656557701528072,
-0.01720796711742878,
-0.004622322972863913,
0.018916400149464607,
-0.0484655499458313,
0.013116720132529736,
0.01685953699052334,
0.03720337897539139,
-0.031471136957407,
0.03333692625164986,
-0.04178917407989502,
-0.006226789206266403,
0.04156437888741493,
0.03884437307715416,
-0.00471505057066679,
0.01025621872395277,
-0.03072931617498398,
0.03090915083885193,
-0.00016060465713962913,
-0.019354749470949173,
0.007772246841341257,
-0.017241686582565308,
-0.013071761466562748,
-0.03459576889872551,
0.028818568214774132,
-0.002583723980933428,
0.016117718070745468,
-0.005661994684487581,
-0.0074069565162062645,
-0.034326016902923584,
0.005558027420192957,
0.019860533997416496,
-0.005167447961866856,
-0.025019552558660507,
-0.010143821127712727,
-0.03767544403672218,
0.02960534766316414,
-0.0016775239491835237,
-0.022411944344639778,
-0.008851257152855396,
-0.008789438754320145,
-0.033381883054971695,
-0.013656225055456161,
-0.03922652453184128,
-0.0035545523278415203,
-0.0017196728149428964,
0.02773955836892128,
0.011734237894415855,
0.04770125076174736,
-0.01999541185796261,
0.03922652453184128,
0.04396967217326164,
0.03439345583319664,
0.012453578412532806,
0.05565895140171051,
0.021861199289560318,
0.02567145600914955,
-0.04878026247024536,
-0.0005798978381790221,
0.05413035303354263,
0.010885640978813171,
-0.02220962941646576,
-0.006209929473698139,
-0.03794519975781441,
0.004717860370874405,
-0.021321695297956467,
-0.006007615011185408,
-0.015589452348649502,
-0.011352088302373886,
-0.016690941527485847,
0.018455572426319122,
0.00499042309820652,
-0.03792271763086319,
-0.051163073629140854,
-0.04160933941602707,
-0.0033690975978970528,
0.0004745257319882512,
0.011722997762262821,
-0.01997293159365654,
-0.015387137420475483,
0.004389099311083555,
-0.010655227117240429,
-0.032280392944812775,
-0.04307049885392189,
0.02254682034254074,
-0.025469141080975533,
-0.04311545565724373,
0.022254589945077896,
-0.024300212040543556,
-0.0026300877798348665,
0.0064628226682543755,
0.005035381764173508,
-0.0024853767827153206,
-0.02089458703994751,
-0.01796102710068226,
0.019669460132718086,
-0.022479383274912834,
0.009930266998708248,
-0.07939717918634415,
0.012824487872421741,
0.016522346064448357,
0.030571959912776947,
-0.02551409974694252,
-0.0174102820456028,
-0.033764034509658813,
0.004026619251817465,
-0.01995045319199562,
-0.007547452580183744,
-0.012419858947396278,
0.04327281191945076,
-0.014094573445618153,
-0.05489465221762657,
0.014330606907606125,
0.005440010689198971,
-0.030482042580842972,
-0.042800743132829666,
0.014634078368544579,
0.012262503616511822,
-0.008514066226780415,
-0.010570929385721684,
-0.0355399027466774,
0.04603777453303337,
0.01923111267387867,
-0.012498537078499794,
0.0020624834578484297,
0.0057519120164215565,
0.01960202120244503,
-0.022872772067785263,
-0.028728650882840157,
-0.012712091207504272,
0.03187576308846474,
-0.011621841229498386,
0.009059191681444645,
-0.022108472883701324,
0.014892591163516045,
-0.009857209399342537,
-0.014060853980481625,
0.018905160948634148,
0.009750432334840298,
0.04756637290120125,
-0.0068674515932798386,
-0.0201640073210001,
0.0058727385476231575,
0.004223314113914967,
-0.012284982949495316,
0.009756051935255527,
-0.003158353269100189,
-0.012127626687288284,
0.012240024283528328,
0.005844639614224434,
-0.03520271182060242,
-0.0027860384434461594,
0.04529595747590065,
0.02238946594297886,
-0.024547485634684563,
0.006474062334746122,
0.0020062848925590515,
0.0491848886013031,
0.018714087083935738,
-0.020793428644537926,
0.00047557943616993725,
0.005302324425429106,
0.010329276323318481,
-0.011245311237871647,
-0.013757382519543171,
-0.005347283091396093,
-0.011116054840385914,
-0.01815210096538067,
0.0011829775758087635,
-0.02071475051343441,
-0.018084663897752762,
-0.012419858947396278,
-0.03500039875507355,
-0.007761006709188223,
0.004984803032130003,
0.03547246754169464,
0.016556065529584885,
-0.01571308821439743,
-0.026885341852903366,
-0.0208833459764719,
0.019512103870511055,
-0.012914405204355717,
-0.01109919510781765,
0.016218874603509903,
-0.05282654985785484,
-0.015038707293570042,
0.004004139918833971,
0.0006375012453645468,
0.00692926999181509,
-0.009210927411913872,
-0.01754515804350376,
0.007036047056317329,
-0.014836392365396023,
-0.024322692304849625,
0.0053276135586202145,
-0.005653564818203449,
-0.006479681935161352,
0.00860398355871439,
-0.024659883230924606,
0.006108772475272417,
-0.010756384581327438,
0.005729432683438063,
0.011745477095246315,
0.017657555639743805,
-0.0051955473609268665,
0.05156770348548889,
0.07382228970527649,
-0.03601197153329849,
0.0175339188426733,
-0.009874069131910801,
-0.011234072037041187,
0.005765961483120918,
-0.019984170794487,
0.0027452947106212378,
-0.0015637220349162817,
0.010340516455471516,
0.013161678798496723,
0.057951848953962326,
-0.002475542016327381,
0.004124966915696859,
-0.023625832051038742,
0.0061762104742228985,
0.011391427367925644,
0.0179497878998518,
-0.027222532778978348,
-0.018635408952832222,
0.008733239956200123,
-0.016376230865716934,
0.0032932294998317957,
-0.04237363487482071,
-0.02845889888703823,
0.007879023440182209,
-0.0038186851888895035,
0.022456903010606766,
0.028908485546708107,
0.008407289162278175,
-0.013903498649597168,
-0.01008762326091528,
-0.013071761466562748,
-0.028706172481179237,
-0.005285464692860842,
-0.002644137479364872,
0.02072599157691002,
0.009868449531495571,
-0.0122063048183918,
-0.009564977139234543,
-0.03156105428934097,
0.021546488627791405,
0.01852301135659218,
0.020040370523929596,
-0.0362592451274395,
0.027492284774780273,
0.005979515612125397,
-0.0036781891249120235,
-0.012273742817342281,
0.012554734945297241,
0.01368994452059269,
0.0026062035467475653,
0.0012911595404148102,
-0.023266160860657692,
-0.012419858947396278,
0.028211625292897224,
0.0027523194439709187,
-0.008924314752221107,
0.02400798164308071,
0.02702021785080433,
0.03513527661561966,
-0.0014948789030313492,
-0.001046696212142706,
-0.004108107183128595,
0.021748803555965424,
0.006710095796734095,
0.029268156737089157,
-0.010790104046463966,
0.037608008831739426,
-0.00555240735411644,
0.029492950066924095,
0.00259215384721756,
-0.008890596218407154,
-0.016533585265278816,
-0.010042664594948292,
0.0021819050889462233,
0.03185328468680382,
-0.04122718796133995,
-0.041137270629405975,
0.010947459377348423,
-0.009874069131910801,
0.00665951706469059,
-0.026008645072579384,
-0.0011871923925355077,
0.0010586384451016784,
0.014353086240589619,
-0.00020705618953797966,
-0.010835062712430954,
-0.0047965385019779205,
0.002958848839625716,
-0.03259510546922684,
0.00877819862216711,
0.006625798065215349,
-0.0186691265553236,
-0.014027134515345097,
0.014757715165615082,
-0.03643907979130745,
0.015027467161417007,
0.0035601721610873938,
-0.030639398843050003,
0.002729840110987425,
-0.042800743132829666,
0.027402367442846298,
-0.013521349057555199,
0.011234072037041187,
-0.00749125424772501,
0.03711346164345741,
0.004608273506164551,
0.009919027797877789,
0.011014897376298904,
0.010835062712430954,
-0.024929635226726532,
-0.000026123501811525784,
0.013847299851477146,
-0.030774274840950966,
-0.023356078192591667,
0.009761672466993332,
-0.014746475033462048,
0.0036922385916113853,
0.0010979773942381144,
-0.008845637552440166,
-0.0009602911304682493,
0.006676376797258854,
-0.00953687820583582,
0.013195397332310677,
0.00932894367724657,
-0.0329098179936409,
0.0017857060302048922,
0.02147904969751835,
-0.01202647015452385,
-0.014386804774403572,
-0.01624135486781597,
0.046667199581861496,
-0.023423517122864723,
0.017646316438913345,
-0.03176336735486984,
-0.011323989368975163,
0.046712156385183334,
-0.05682788044214249,
0.020624833181500435,
0.02328864112496376,
-0.03308965265750885,
-0.012127626687288284,
0.007249601185321808,
-0.03477560356259346,
-0.0026567820459604263,
0.02313128486275673,
-0.027986831963062286,
0.01320663746446371,
-0.003815875155851245,
-0.00033806884312070906,
0.010228118859231472,
0.007744147442281246,
-0.008817537687718868,
-0.0011619031429290771,
-0.06788773834705353,
0.012431099079549313,
0.022659217938780785,
-0.024142857640981674,
0.002024549525231123,
-0.018961358815431595,
0.046891991049051285,
-0.006940509658306837,
0.014004655182361603,
-0.013577546924352646,
-0.010430433787405491,
-0.05048869550228119,
-0.06060441583395004,
-0.01960202120244503,
0.04680207371711731,
-0.06559483706951141,
0.03279741853475571,
-0.024322692304849625,
-0.03823743015527725,
0.034685686230659485,
-0.007064145989716053,
-0.016567304730415344,
-0.010065143927931786,
0.00887935608625412,
0.012644653208553791,
0.039653632789850235,
0.019298549741506577,
-0.0183094572275877,
-0.02735740877687931,
-0.0056395153515040874,
-0.018725326284766197,
0.0006782451528124511,
0.004951084032654762,
0.015769287943840027,
-0.03108898736536503,
-0.027851955965161324,
-0.022456903010606766,
0.004906125366687775,
-0.01624135486781597,
-0.00969985406845808,
0.020253924652934074,
0.020804669708013535,
0.018275737762451172,
-0.024322692304849625,
0.05120803415775299,
0.033943869173526764,
-0.023738227784633636,
-0.027649641036987305,
-0.0056395153515040874,
-0.030954109504818916,
0.020568635314702988,
-0.04309297725558281,
0.005678853951394558,
-0.027672119438648224,
0.02425525337457657,
-0.02308632619678974,
0.04958951845765114,
-0.017286645248532295,
-0.003178022801876068,
0.0016662842826917768,
-0.005350092891603708,
-0.0027790137100964785,
0.007575551979243755,
-0.01926483027637005,
0.004420008510351181,
-0.007699188776314259,
0.009570597670972347,
-0.01995045319199562,
-0.00680001312866807,
-0.03497792035341263,
0.010660847648978233,
0.03070683777332306,
-0.005156208295375109,
0.01888268068432808,
-0.012667132541537285,
0.019478384405374527,
-0.009570597670972347,
0.0006617368198931217,
-0.037090983241796494,
0.00214959098957479,
0.0053444732911884785,
-0.0015201682690531015,
-0.00887935608625412,
0.015398377552628517,
-0.0362592451274395,
0.015128624625504017,
-0.03268502280116081,
-0.014386804774403572,
-0.022816574200987816,
0.027806997299194336,
-0.006530260667204857,
-0.005288274958729744,
-0.011234072037041187,
0.021692603826522827,
-0.014375565573573112,
0.03344932198524475,
0.00026711830287240446,
0.0006810550694353878,
-0.033404361456632614,
0.027672119438648224,
0.006642657797783613,
0.020456237718462944,
-0.0019388467771932483,
0.07161931693553925,
0.020973263308405876,
-0.01358878705650568,
-0.023401036858558655,
-0.011599361896514893,
-0.037248335778713226,
-0.03969858959317207,
0.018905160948634148,
-0.0030796753708273172,
0.009935887530446053,
0.025446660816669464,
0.01358878705650568,
-0.00015357985103037208,
0.009210927411913872,
-0.0218387208878994,
0.023895584046840668,
-0.019174912944436073,
0.02776203863322735,
0.0038102553226053715,
0.02369326911866665,
-0.011279030703008175,
-0.009300844743847847,
-0.02034384198486805,
-0.011857874691486359,
0.02976270206272602,
-0.019748138263821602,
-0.03104402683675289,
-0.004819017834961414,
0.019455906003713608,
-0.018455572426319122,
-0.025783851742744446,
0.007384477183222771,
0.05282654985785484,
0.06694360077381134,
0.026907822117209435,
0.009092910215258598,
-0.014768954366445541,
-0.01404961384832859,
-0.02623344026505947,
0.021209297701716423,
-0.04012569785118103,
0.06069433316588402,
-0.024997074156999588,
-0.003917032387107611,
0.022288307547569275,
0.006642657797783613,
-0.003734387457370758,
0.004816207569092512,
0.06145863234996796,
-0.003270750166848302,
-0.007036047056317329,
-0.04833067208528519,
0.031201383098959923,
-0.005645134951919317,
-0.0019149624276906252,
0.03066187910735607,
0.016522346064448357,
0.020770950242877007,
0.03774288296699524,
0.014184490777552128,
-0.041339583694934845,
0.022220870479941368,
0.02126549556851387,
0.02400798164308071,
0.01995045319199562,
-0.023176243528723717,
-0.011790436692535877,
-0.03646155819296837,
0.0020526486914604902,
-0.017511438578367233,
-0.012846967205405235,
-0.010576549917459488,
0.02272665686905384,
0.03900172933936119,
0.044306863099336624,
-0.03178584575653076,
0.00044080664520151913,
0.007457535248249769,
-0.029155759140849113,
0.00953125860542059,
-0.04486884921789169,
0.004040669184178114,
0.04017065837979317,
-0.030774274840950966,
-0.0029447991400957108,
0.024839717894792557,
0.007305799517780542,
-0.028234105557203293,
-0.026480713859200478,
0.03268502280116081,
-0.017713753506541252,
0.038372308015823364,
-0.038372308015823364,
0.0329098179936409,
0.00312182423658669,
0.021771281957626343,
0.022872772067785263,
-0.00015340422396548092,
-0.04183413088321686,
-0.018792763352394104,
-0.04644240438938141,
-0.030212290585041046,
-0.024682361632585526,
-0.022816574200987816,
-0.032617583870887756,
0.012161346152424812,
0.04192404821515083,
0.016308791935443878,
0.008519685827195644,
0.005608606152236462,
-0.023401036858558655,
0.019658220931887627,
0.02051243744790554,
0.016769619658589363,
0.014915070496499538,
0.0026230630464851856,
-0.03776536136865616,
-0.01812962256371975,
0.021737562492489815,
0.00042254215804859996,
0.05885102599859238,
0.034146182239055634,
0.007856544107198715,
-0.06824740767478943,
-0.008946794085204601,
0.015522013418376446,
0.013925977982580662,
-0.023401036858558655,
0.00046223230310715735,
-0.02776203863322735,
-0.02773955836892128,
0.004200834780931473,
0.004726290237158537,
0.012543495744466782,
0.06348177790641785,
0.021917399019002914,
0.022524341940879822,
0.0016367800999432802,
0.011599361896514893,
0.005572076886892319,
0.010143821127712727,
-0.013948457315564156,
0.002114466857165098,
-0.014274408109486103,
0.03239279240369797,
0.004420008510351181,
-0.0054737296886742115,
-0.02349095419049263,
-0.002850666642189026,
0.033584196120500565,
0.01864664815366268,
0.002569674514234066,
-0.009963986463844776,
0.019646979868412018,
0.005647944752126932,
-0.024907156825065613,
0.014015895314514637,
-0.005161828361451626,
-0.0056142257526516914,
-0.01026745792478323,
-0.016949454322457314,
0.014577879570424557,
-0.030189810320734978,
-0.017848629504442215,
0.011234072037041187,
0.035247672349214554,
-0.0160952378064394,
-0.005957036279141903,
-0.017848629504442215,
-0.006608938332647085,
-0.024277733638882637,
0.023243682458996773,
-0.009188448078930378,
-0.015611931681632996,
-0.00609753280878067,
-0.017859870567917824,
-0.0029785181395709515,
-0.005220836494117975,
0.001414093654602766,
-0.006063813343644142,
0.00499604269862175,
0.014364325441420078,
0.0038186851888895035,
-0.014926310628652573,
0.00023445293481927365,
-0.003178022801876068,
-0.03324700891971588,
-0.03850718215107918,
0.05399547889828682,
-0.013330274261534214,
-0.039114125072956085,
0.02549161948263645,
0.03257262706756592,
0.011689279228448868,
0.020029129460453987,
0.0029644686728715897,
-0.011801675893366337,
0.024502526968717575,
0.030999068170785904,
0.020208965986967087,
0.02403046004474163,
0.0071540637873113155,
0.023221202194690704,
-0.04477893188595772,
-0.04053032770752907,
-0.014858871698379517,
0.007907123304903507,
0.006496541667729616,
-0.008480346761643887,
-0.011700518429279327,
0.03441593423485756,
-0.0027551292441785336,
0.01275704987347126,
0.0025893438141793013,
0.008738860487937927,
0.01358878705650568,
-0.008811918087303638,
-0.015623170882463455,
-0.001490664086304605,
0.028773609548807144,
-0.0061762104742228985,
0.008412908762693405,
0.007446295581758022,
0.028908485546708107,
0.012363660149276257,
-0.006569599732756615,
-0.03619180619716644,
0.004827447235584259,
-0.02569393441081047,
-0.013274075463414192,
0.04518355801701546,
-0.027289971709251404,
-0.036551475524902344,
0.04158685728907585,
0.0440371111035347,
-0.028526335954666138,
-0.016938215121626854,
0.027851955965161324,
0.003616370726376772,
-0.0034112464636564255,
-0.014960029162466526,
0.030594440177083015,
0.03201064094901085,
-0.015600691549479961,
-0.0017042182153090835,
0.000591137504670769,
-0.021040702238678932,
0.001418308587744832,
-0.002427773317322135,
-0.014555400237441063,
0.01829821802675724,
0.02513195015490055,
-0.027649641036987305,
0.009283985011279583,
0.02479475922882557,
0.024525007233023643,
0.037068501114845276,
0.008795058354735374,
-0.02032136172056198,
0.03304469212889671,
0.002784633543342352,
-0.007805965840816498,
-0.004391909576952457,
-0.022074753418564796,
-0.014094573445618153,
-0.009239026345312595,
-0.03828239068388939,
-0.004546455107629299,
0.004490256775170565,
0.011492584832012653,
0.0023828146513551474,
-0.026907822117209435,
-0.015971601009368896,
-0.004389099311083555,
-0.022681698203086853,
0.014341846108436584,
0.006108772475272417,
-0.012970604002475739,
-0.030482042580842972,
0.01536465808749199,
-0.02443508990108967,
-0.0347081683576107,
0.02367079071700573,
-0.016544826328754425,
0.009390762075781822,
0.023445995524525642,
0.0029391793068498373,
0.03823743015527725,
0.008817537687718868,
-0.0025640546809881926,
-0.012712091207504272,
0.0023041367530822754,
-0.08186991512775421,
0.030054934322834015,
-0.023760708048939705,
-0.016915734857320786,
0.007131583988666534,
-0.025559058412909508,
-0.049094971269369125,
-0.01099241804331541,
0.0017505818977952003,
-0.02272665686905384,
-0.009239026345312595,
-0.00030751092708669603,
-0.0009645060054026544,
0.013352753594517708,
0.008384809829294682,
-0.015634410083293915,
-0.007890263572335243,
-0.018197059631347656,
0.010627128183841705,
0.009267125278711319,
0.001070580561645329,
-0.02699773944914341,
-0.03666387498378754,
0.012689611874520779,
-0.003060006070882082,
0.015825485810637474,
-0.02663806825876236,
0.007446295581758022,
-0.010790104046463966,
-0.022614259272813797,
0.04940968379378319,
0.01828697882592678,
0.0019037227611988783,
-0.02866121381521225,
-0.021344173699617386,
-0.017444001510739326,
0.0035405028611421585,
0.04255347326397896,
0.014206970110535622,
0.024322692304849625,
-0.017275406047701836,
0.006395384203642607,
-0.018388135358691216,
0.00763175031170249,
-0.04066520184278488,
0.008722000755369663,
0.016151435673236847,
0.01137456763535738,
-0.020759709179401398,
-0.023423517122864723,
-0.00166347436606884,
0.01627507247030735,
-0.00821621436625719,
0.018635408952832222,
-0.03682122752070427,
-0.007957701571285725,
-0.01757887750864029,
-0.02605360560119152,
0.0013600026722997427,
0.03144865483045578,
0.0350678376853466,
-0.021377893164753914,
0.009402002207934856,
-0.03488800302147865,
0.05152274668216705,
-0.004310421645641327,
-0.004532405640929937,
-0.023401036858558655,
-0.014690276235342026,
0.00458017410710454,
0.015409616753458977,
-0.004467777442187071,
-0.0043553803116083145,
0.02850385755300522,
-0.02684038318693638,
-0.014094573445618153,
0.036708831787109375,
-0.020377561450004578,
0.004203644581139088,
0.011914072558283806,
0.006940509658306837,
0.022411944344639778,
-0.009121009148657322,
-0.0169944129884243,
0.012948124669492245,
-0.013094240799546242,
-0.008581504225730896,
-0.006625798065215349,
0.004745959769934416,
0.016926975920796394,
-0.0025598397478461266,
-0.010913739912211895,
-0.006502161268144846,
0.000501219998113811,
-0.037832800298929214,
-0.07161931693553925,
-0.013431430794298649,
0.017297884449362755,
-0.011959031224250793,
-0.00457455450668931,
-0.0016438048332929611,
0.012442338280379772,
0.04322785139083862,
-0.046352487057447433,
-0.018455572426319122,
0.042261239141225815,
0.02068103291094303,
0.011026137508451939,
0.002201574621722102,
-0.0008514065993949771,
0.009188448078930378,
-0.007834064774215221,
0.018714087083935738,
0.0032932294998317957,
0.0027719889767467976,
0.018601689487695694,
-0.038552142679691315,
0.010514731518924236,
0.03628172352910042,
0.01071704551577568,
-0.006041334010660648,
0.015117385424673557,
-0.007957701571285725,
0.056108538061380386,
-0.015758046880364418,
0.0010382664622738957,
-0.007985800504684448,
0.011734237894415855,
-0.037090983241796494,
-0.0016466147499158978,
0.019883014261722565,
0.0018924830947071314,
0.007435055915266275,
0.02253558114171028,
0.043340250849723816,
-0.02551409974694252,
-0.004962323699146509,
0.018916400149464607,
0.031156424432992935,
-0.00609753280878067,
0.007227121386677027,
-0.025086991488933563,
-0.0366189144551754,
-0.020467478781938553,
0.012667132541537285,
0.00034878167207352817,
-0.01627507247030735,
0.02036632038652897,
0.018635408952832222,
-0.006226789206266403,
0.016499867662787437,
-0.000884423207025975,
0.017106810584664345,
-0.008435388095676899,
-0.024367650970816612,
-0.0009511588723398745,
-0.009857209399342537,
0.008474727161228657,
-0.011902833357453346,
-0.021130619570612907,
-0.008294892497360706,
-0.00041446363320574164,
-0.02720005251467228,
0.04048536717891693,
-0.015072425827383995,
-0.008811918087303638,
0.026121042668819427,
-0.02922319807112217,
-0.009851589798927307,
0.033741552382707596,
-0.004313231445848942,
0.022063514217734337,
-0.01572432741522789,
-0.020253924652934074,
-0.028616255149245262,
-0.015578212216496468,
-0.010132581926882267,
0.007457535248249769,
-0.04214884340763092,
-0.001249713241122663,
0.014487962238490582,
-0.004675711505115032,
0.0019247971940785646,
0.029897579923272133,
0.006316706538200378,
0.016376230865716934,
-0.024884676560759544,
0.013408951461315155,
0.001300291856750846,
0.015803005546331406,
-0.0033128990326076746,
-0.036708831787109375,
0.005302324425429106,
-0.009829110465943813,
-0.020669791847467422,
-0.04174421355128288,
-0.022692937403917313,
0.02569393441081047,
-0.028234105557203293,
-0.017095571383833885,
0.003546122694388032,
0.012037709355354309,
-0.003706288291141391,
0.030999068170785904,
-0.050623569637537,
-0.013453911058604717,
-0.013813580386340618,
0.012127626687288284,
0.01360002625733614,
0.023783186450600624,
-0.008356710895895958,
0.026525672525167465,
0.003978850785642862,
0.02812170796096325,
0.007092245388776064,
0.004220504313707352,
0.024637402966618538,
0.0031555434688925743,
-0.03843974322080612,
0.002208599355071783,
0.026323357596993446,
-0.038731977343559265,
-0.030234770849347115,
-0.008193735033273697,
-0.03502287715673447,
0.019894253462553024,
-0.0283015426248312,
0.014690276235342026,
0.03275246173143387,
0.011155393905937672,
-0.005945796612650156,
0.02773955836892128,
-0.032819900661706924,
0.007255220785737038,
-0.014443003572523594,
-0.020422520115971565,
-0.012903166003525257,
-0.008283652365207672,
-0.04509364068508148,
0.012565975077450275,
-0.009317704476416111,
0.01592664234340191,
0.018433094024658203,
0.01175671722739935,
-0.009632415138185024,
0.004616703372448683,
-0.02072599157691002,
0.0026539722457528114,
0.006996707990765572,
0.003619180526584387,
-0.010778863914310932,
0.013071761466562748,
0.012835728004574776,
-0.010171920992434025,
0.013251596130430698,
0.011082335375249386,
-0.023535914719104767,
-0.02684038318693638,
-0.008233074098825455,
0.016308791935443878,
-0.033764034509658813,
-0.01865788735449314,
0.08519686013460159,
-0.048735301941633224,
0.006715715397149324,
-0.0017660364974290133,
0.013240356929600239,
-0.05228704586625099,
0.0018952930113300681,
-0.012172585353255272,
0.009205306880176067,
-0.012554734945297241,
0.0221983902156353,
0.00325670070014894,
0.040238093584775925,
0.02126549556851387,
0.022513102740049362,
-0.021580208092927933,
0.014240688644349575,
0.03902420774102211,
0.013352753594517708,
-0.02124301716685295,
0.006299847271293402,
0.017309125512838364,
-0.0008211999665945768,
0.03664139285683632,
-0.03308965265750885,
-0.0014232259709388018,
-0.001729507464915514,
-0.010514731518924236,
-0.013071761466562748,
-0.006395384203642607,
0.017814910039305687,
0.008924314752221107,
0.03583213686943054,
-0.030571959912776947,
0.012678371742367744,
-0.02456996589899063,
-0.0021397562231868505,
-0.009379522874951363,
-0.008991752751171589,
0.021760042756795883,
0.007440675515681505,
0.029830140992999077,
0.0010298367124050856,
-0.026008645072579384,
0.01848929189145565,
0.0018910780781880021,
-0.028975924476981163,
0.01431936677545309,
0.004175545182079077,
-0.02290649153292179,
0.0064459629356861115,
-0.006198689807206392,
0.024120377376675606,
-0.032302871346473694,
-0.031313780695199966,
-0.011458865366876125,
-0.002388434484601021,
-0.0035095936618745327,
-0.011144153773784637,
-0.027110135182738304,
0.009621175937354565,
0.027222532778978348,
0.009874069131910801,
-0.003872073721140623,
-0.007547452580183744
] | 2025-01-12 | 1 | 39798497 | [
"cell culture media",
"CAR)-T cell therapy",
"cancer cells",
"culture media optimization",
"solid tumors",
"basic culture media",
"CAR-T cell therapy",
"CAR-T cell phenotypes",
"CAR-T cells",
"specific additives",
"hematological cancers",
"additives",
"cancer patients",
"Cancer",
"the culture media additives",
"the challenging solid tumor microenvironment",
"exhaustion",
"novel strategies",
"chimeric antigen receptor",
"various types",
"formidable obstacles",
"insights",
"action",
"CAR)-T",
"their anti-tumor efficacy",
"exhaustion and augment persistence",
"researchers",
"promise",
"functionality",
"outcomes"
] | [
"CAR-T cell therapy",
"Culture media additives",
"Memory phenotype",
"T cell exhaustion",
"immunotherapy"
] | 0 | 10.1016/j.retram.2024.103491 | [
"Chen",
"Xu",
"Guo",
"Zhou"
] | [
"Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.",
"Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.",
"Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. Electronic address: [email protected].",
"Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. Electronic address: [email protected]."
] | [
"39798497"
] | [] | 9.908972 | 4.780149 |
39798230 | 41 | CAR-T cell therapy for breast cancer: Current status and future perspective. | Within the expanding therapeutic landscape for breast cancer (BC), metastatic breast cancer (MBC) remains virtually incurable and tend to develop resistance to conventional treatments ultimately leading to metastatic progression and death. Cellular immunotherapy (CI), particularly chimeric antigen receptor-engineered T (CAR-T) cells, has emerged as a promising approach for addressing this challenge. In the wake of their striking efficacy against hematological cancers, CAR-T cells have also been used where the clinical need is greatest - in patients with aggressive BCs. Unfortunately, current outcomes fall considerably short of replicating that success, primarily owing to the scarcity of tumor-specific antigens and the immunosuppressive microenvironment within BC. Herein, we provide an up-to-date overview of both preclinical and clinical data concerning the application of CAR-T cell therapy in BC. By surveying the existing literature, we discuss the prevailing constrains of this therapeutic approach and overview possible strategies to advance it in the context of breast malignancies. Possible approaches include employing synthetic biology to refine antigen targeting and mitigate off-target toxicity, utilizing logic-gated CAR constructs to enhance specificity, and leveraging armored CARs to remodel the tumor micro-environment. Temporal and spatial regulation of CAR-T cells using inducible gene switches and external triggers further improves safety and functionality. In addition, promoting T cell homing through chemokine receptor engineering and enhancing manufacturing processes with universal CAR platforms expand therapeutic applicability. These innovations not only address antigen escape and T cell exhaustion but also optimize the efficacy and safety profile of CAR-T cell therapy. We, therefore, outline a trajectory wherein CAR-T cells may evolve from a promising experimental approach to a standard modality in BC therapy. | [
0.05426102131605148,
0.026762327179312706,
0.06263719499111176,
0.05283430963754654,
-0.0460919514298439,
-0.015141540206968784,
0.024783341214060783,
0.010182570666074753,
-0.020917415618896484,
0.03732458874583244,
0.00858327466994524,
-0.02230961062014103,
-0.016775354743003845,
0.010769362561404705,
0.02259725332260132,
0.0020667167846113443,
0.05817297101020813,
-0.002240740926936269,
0.021469691768288612,
0.017546238377690315,
0.011816384270787239,
0.00048755528405308723,
-0.010073265992105007,
0.011258356273174286,
-0.04029306396842003,
-0.002640564925968647,
-0.00048827441059984267,
0.014106024987995625,
-0.05306442454457283,
-0.01206951029598713,
0.018017971888184547,
-0.01996244117617607,
-0.05334056168794632,
-0.01815604232251644,
-0.012081015855073929,
0.033688776195049286,
0.02510550245642662,
-0.0028102744836360216,
-0.0001816646836232394,
-0.008692578412592411,
0.046552181243896484,
0.017339134588837624,
0.009135548956692219,
0.09922540932893753,
-0.07879123836755753,
-0.014796368777751923,
-0.02795892395079136,
-0.057298533618450165,
-0.026762327179312706,
0.002913826145231724,
-0.020825371146202087,
0.007714591920375824,
-0.02003147453069687,
0.024967433884739876,
-0.039372608065605164,
0.02304597571492195,
-0.07202586531639099,
0.004386559594422579,
0.008704084903001785,
0.02227509208023548,
0.005988732445985079,
-0.023138022050261497,
-0.0022651904728263617,
-0.011062758974730968,
-0.0719338208436966,
0.028626255691051483,
-0.025266582146286964,
-0.011873912997543812,
0.008525745943188667,
0.02413902059197426,
0.031686779111623764,
-0.031157515943050385,
-0.006034755147993565,
0.05568773299455643,
0.03672628849744797,
0.004386559594422579,
-0.010959207080304623,
0.02713051065802574,
-0.003112299833446741,
-0.03663424402475357,
0.02156173810362816,
-0.026233064010739326,
0.0384061262011528,
-0.043422624468803406,
-0.02791289985179901,
0.007657063193619251,
0.02616402879357338,
-0.0015719702932983637,
-0.05288033187389374,
-0.02512851357460022,
-0.03868226334452629,
0.011730091646313667,
-0.03640412911772728,
0.026094995439052582,
-0.008289878256618977,
0.03647316247224808,
-0.018650786951184273,
-0.08307136595249176,
0.027797842398285866,
0.016015974804759026,
0.05693035200238228,
-0.004032758064568043,
-0.009664813056588173,
-0.019686304032802582,
0.06208491697907448,
-0.01334664598107338,
-0.060336045920848846,
0.01334664598107338,
0.01565929874777794,
0.007455712649971247,
0.022988447919487953,
-0.010993724688887596,
0.012196073308587074,
0.053662724792957306,
-0.029822850599884987,
-0.049106452614068985,
-0.028373129665851593,
-0.001364867202937603,
0.01309351995587349,
0.03150268644094467,
-0.028073979541659355,
0.03789987415075302,
0.03465525805950165,
-0.012368659488856792,
0.0020868517458438873,
-0.03737061098217964,
0.07009290158748627,
-0.016061998903751373,
-0.03812998905777931,
-0.046253032982349396,
0.03688737004995346,
0.009722341783344746,
0.03520753234624863,
-0.017327629029750824,
-0.06765369325876236,
-0.0192490853369236,
-0.03226206451654434,
0.017845386639237404,
-0.028557220473885536,
-0.012920934706926346,
0.039073459804058075,
-0.003955094609409571,
-0.002532698679715395,
-0.006103789433836937,
-0.03911948204040527,
-0.04800190404057503,
0.01896144263446331,
0.021377645432949066,
-0.0016899040201678872,
0.04183483123779297,
-0.03431008756160736,
0.028004946187138557,
0.03635810688138008,
-0.001968917902559042,
0.013208577409386635,
-0.045470643788576126,
-0.028925403952598572,
0.08067817986011505,
-0.008819141425192356,
-0.07920544594526291,
-0.011384919285774231,
-0.004119051154702902,
-0.042640235275030136,
-0.038567204028367996,
0.049336567521095276,
-0.013300623744726181,
-0.024990445002913475,
0.02540465071797371,
-0.06885028630495071,
-0.008980222046375275,
-0.008531498722732067,
-0.049060430377721786,
-0.07299234718084335,
-0.03000694327056408,
-0.04749565199017525,
0.0070760236121714115,
0.0333666168153286,
-0.012644796632230282,
-0.0006331746699288487,
-0.013519232161343098,
-0.006259116809815168,
0.02793591096997261,
0.03948766365647316,
0.006713593378663063,
-0.029546713456511497,
0.020882898941636086,
0.0018682428635656834,
0.021320117637515068,
-0.05251215025782585,
-0.03872828558087349,
-0.00933689996600151,
-0.01950221136212349,
0.0358288437128067,
0.02611800655722618,
0.021159036085009575,
0.01975533738732338,
0.04022403061389923,
0.0281660258769989,
-0.025266582146286964,
-0.008157562464475632,
0.04413598030805588,
-0.01715504378080368,
-0.006955213379114866,
0.01510702259838581,
-0.026071984320878983,
-0.034010935574769974,
-0.028534209355711937,
0.02280435711145401,
-0.001292956410907209,
0.01974383182823658,
0.03127257153391838,
-0.009417439810931683,
-0.010706081055104733,
0.02459925040602684,
-0.03207797557115555,
-0.050901349633932114,
-0.010412685573101044,
0.03152569755911827,
0.019088005647063255,
0.020365141332149506,
-0.006834403611719608,
-0.0018481077859178185,
0.007208339869976044,
0.019364142790436745,
-0.014876908622682095,
-0.0028016450814902782,
0.01747720316052437,
-0.019064994528889656,
-0.014301622286438942,
-0.04040812328457832,
-0.021941427141427994,
0.003584034740924835,
0.0513615757226944,
-0.00834740698337555,
-0.04544763267040253,
-0.03944164142012596,
0.041351594030857086,
0.03465525805950165,
0.054721251130104065,
-0.03205496445298195,
0.00987191591411829,
0.027061475440859795,
0.027061475440859795,
-0.025473685935139656,
-0.03076632134616375,
0.008030999451875687,
-0.017028480768203735,
-0.08233500272035599,
0.012403176166117191,
0.0036674514412879944,
-0.004711596295237541,
-0.011735844425857067,
-0.004725978244096041,
-0.022700805217027664,
0.019824372604489326,
0.026785338297486305,
0.0230689886957407,
-0.0036185518838465214,
0.010694575496017933,
-0.022102506831288338,
-0.00454188697040081,
0.006725098937749863,
-0.03707146272063255,
-0.05297238007187843,
-0.045746780931949615,
0.0017488709418103099,
-0.008755859918892384,
-0.017120525240898132,
0.05559568479657173,
-0.008123044855892658,
0.018144534900784492,
0.03916550427675247,
0.04850815609097481,
-0.028833359479904175,
-0.06466220319271088,
-0.0013699008850380778,
-0.017879903316497803,
0.0358518548309803,
0.004331907257437706,
0.026992442086338997,
-0.011103029362857342,
0.020158037543296814,
-0.000492589024361223,
-0.023218562826514244,
0.01840916834771633,
0.00043793683289550245,
-0.013910426758229733,
-0.00531277060508728,
-0.0005627020727843046,
-0.0384751595556736,
-0.00742694828659296,
-0.005191960372030735,
-0.05099339410662651,
-0.007265868131071329,
-0.014416679739952087,
-0.013657300733029842,
0.03559872880578041,
-0.008289878256618977,
-0.024162031710147858,
0.04558569937944412,
-0.04312347620725632,
0.017086008563637733,
-0.029293587431311607,
-0.019939430058002472,
0.03769277036190033,
-0.011689821258187294,
0.008807635866105556,
-0.021078497171401978,
0.03725555166602135,
0.04535558819770813,
0.005936956498771906,
-0.023632768541574478,
0.027314601466059685,
0.005330029409378767,
-0.013415681198239326,
0.02641715481877327,
-0.004515998996794224,
-0.06360367685556412,
-0.004027005285024643,
-0.039878860116004944,
-0.07510939985513687,
0.01741967536509037,
-0.04464223235845566,
0.0039205774664878845,
0.011965958401560783,
-0.035483669489622116,
0.0166718028485775,
-0.008266867138445377,
0.05435306578874588,
-0.03771578148007393,
0.019053488969802856,
-0.04259421303868294,
0.05246612802147865,
-0.040638238191604614,
-0.0035408881958574057,
-0.005125802475959063,
-0.025496697053313255,
-0.03131859749555588,
0.02226358652114868,
-0.014577759429812431,
0.02388589456677437,
0.04224903881549835,
-0.030950412154197693,
0.06351162493228912,
0.013956449925899506,
0.01232263632118702,
-0.004927328787744045,
0.035276565700769424,
-0.002256561303511262,
0.030145011842250824,
0.01740816980600357,
0.02230961062014103,
0.03304445743560791,
0.00059973617317155,
-0.011103029362857342,
0.019064994528889656,
0.00037249800516292453,
-0.0006921415333636105,
0.029431656002998352,
-0.017764845862984657,
0.008261114358901978,
0.0012325512943789363,
-0.0095957787707448,
0.03134160861372948,
0.0383601039648056,
0.05518148094415665,
-0.0281890369951725,
0.030191034078598022,
-0.029086485505104065,
-0.03359673172235489,
-0.029086485505104065,
-0.02283887378871441,
0.021849380806088448,
0.015210574492812157,
-0.015199068933725357,
0.014175059273838997,
0.013818381354212761,
0.004605168476700783,
0.017615271732211113,
0.01970931515097618,
0.018397660925984383,
-0.021136024966835976,
-0.027291590347886086,
-0.024967433884739876,
0.013657300733029842,
0.04169676452875137,
0.05297238007187843,
-0.038337092846632004,
-0.09144753962755203,
0.007783626206219196,
-0.009037750773131847,
0.0010657182428985834,
-0.00007424790965160355,
-0.011730091646313667,
-0.02126258797943592,
0.039602722972631454,
-0.028304094448685646,
0.07138154655694962,
0.05720648914575577,
0.031663767993450165,
0.00033726170659065247,
-0.0332975834608078,
-0.016798365861177444,
-0.047311559319496155,
0.04119051247835159,
-0.028902392834424973,
0.056792281568050385,
0.014013978652656078,
0.013703323900699615,
-0.002896567340940237,
-0.010964960791170597,
0.004734607879072428,
0.02717653289437294,
0.010976466350257397,
0.02945466712117195,
-0.02439214661717415,
-0.04155869409441948,
0.046253032982349396,
-0.004536133725196123,
0.029132507741451263,
0.039855848997831345,
-0.050901349633932114,
0.011977464891970158,
-0.00265494710765779,
-0.010309133678674698,
0.020848382264375687,
0.03357372060418129,
-0.00033762125531211495,
-0.025795845314860344,
-0.04146664962172508,
-0.024300100281834602,
0.07524747401475906,
-0.006213094107806683,
0.003129558404907584,
-0.007231350988149643,
0.050118956714868546,
-0.026739316061139107,
0.012909429147839546,
-0.04045414552092552,
0.02356373518705368,
-0.04505643621087074,
-0.035782817751169205,
-0.020181050524115562,
-0.027866877615451813,
0.02050320990383625,
0.023931916803121567,
0.004196715075522661,
0.009227595292031765,
-0.013887415640056133,
-0.03212399780750275,
-0.003328032325953245,
-0.03691038116812706,
0.028649266809225082,
0.005007868632674217,
-0.02945466712117195,
-0.01850121282041073,
0.033343605697155,
-0.07395882904529572,
0.01205800473690033,
0.0191915575414896,
0.05237407982349396,
-0.02487538754940033,
0.015176057815551758,
-0.035230543464422226,
0.0023011460434645414,
0.03656521067023277,
0.03992488235235214,
-0.004426829516887665,
-0.02201046049594879,
-0.042709268629550934,
0.05430704355239868,
0.022114012390375137,
-0.01526810321956873,
0.007398184388875961,
-0.015026482753455639,
0.034977417439222336,
0.014646793715655804,
0.015037988312542439,
0.007737603038549423,
0.004746113438159227,
-0.009791376069188118,
-0.010654306039214134,
-0.02848818711936474,
0.004121927544474602,
0.0255887433886528,
0.004314648453146219,
-0.027521705254912376,
0.007375172805041075,
0.004055769648402929,
0.01896144263446331,
-0.01567080430686474,
-0.0020652785897254944,
-0.005353040527552366,
-0.009285124018788338,
-0.0004253524530213326,
-0.021860886365175247,
-0.03076632134616375,
-0.005097038112580776,
-0.030122000724077225,
0.03306746855378151,
0.0007086810655891895,
0.026325110346078873,
-0.003420078195631504,
0.011718586087226868,
0.025496697053313255,
0.03978681191802025,
0.009745352901518345,
0.053662724792957306,
-0.007542005740106106,
-0.005301265046000481,
-0.05002691224217415,
-0.03718651831150055,
0.027843866497278214,
-0.018788857385516167,
-0.005749988369643688,
0.012690819799900055,
-0.05195987597107887,
0.0003228795249015093,
0.007139305118471384,
0.010286122560501099,
-0.005171825643628836,
-0.0055227503180503845,
0.005160319618880749,
0.02358674630522728,
0.018017971888184547,
-0.015624781139194965,
-0.03955669701099396,
-0.02388589456677437,
-0.0294776801019907,
-0.05794285610318184,
0.00910103227943182,
-0.019858889281749725,
-0.010867161676287651,
0.0017172301886603236,
-0.02228659763932228,
-0.027544716373085976,
-0.033734798431396484,
0.015843389555811882,
-0.008157562464475632,
-0.02692340686917305,
0.02485237643122673,
-0.008761612698435783,
0.006604288704693317,
0.005516997538506985,
-0.018110018223524094,
0.031663767993450165,
-0.0005792416050098836,
-0.008364665322005749,
0.014313127845525742,
0.00454763974994421,
0.01180487871170044,
-0.020307613536715508,
-0.004081657622009516,
0.004711596295237541,
0.03002995438873768,
-0.010844150558114052,
0.017350640147924423,
-0.0487382709980011,
-0.011373413726687431,
-0.03944164142012596,
0.004973351489752531,
-0.008790377527475357,
0.03405696153640747,
-0.013990967534482479,
-0.005977226421236992,
0.01257576234638691,
-0.017062997445464134,
-0.012897922657430172,
-0.032423146069049835,
0.0010801004245877266,
-0.004645438399165869,
-0.002634812146425247,
0.004003993701189756,
-0.015831883996725082,
0.036772310733795166,
0.006771122105419636,
-0.0013418557355180383,
0.00454188697040081,
-0.0024334618356078863,
0.02489839866757393,
-0.032400134950876236,
-0.003408572403714061,
-0.017097514122724533,
0.04800190404057503,
-0.0034488425590097904,
0.018535731360316277,
-0.026302097365260124,
-0.012000476010143757,
-0.0030145011842250824,
0.013105026446282864,
-0.0027081610169261694,
-0.010838397778570652,
0.033412639051675797,
0.005183331202715635,
-0.028856370598077774,
0.02591090276837349,
-0.004956093151122332,
0.002896567340940237,
-0.029040461406111717,
0.0023399777710437775,
0.019111016765236855,
-0.01615404523909092,
-0.00793320033699274,
-0.03233110159635544,
-0.05403090640902519,
0.030122000724077225,
0.008778871968388557,
-0.02227509208023548,
0.001095201587304473,
0.01746569760143757,
0.03134160861372948,
0.031111493706703186,
-0.01152874156832695,
-0.013645795173943043,
0.01870831660926342,
0.0034661011304706335,
-0.025013456121087074,
-0.022229069843888283,
0.025036467239260674,
-0.005281129851937294,
0.006972472183406353,
-0.0021573242265731096,
-0.026233064010739326,
-0.005108544137328863,
-0.009141302667558193,
-0.060151953250169754,
-0.003883183700963855,
-0.015624781139194965,
0.033481672406196594,
-0.001128280651755631,
-0.009244853630661964,
-0.030329102650284767,
-0.0256807878613472,
0.03723254054784775,
-0.0007867042440921068,
-0.03180183842778206,
0.020457187667489052,
-0.007185328286141157,
-0.0006630176794715226,
0.012426188215613365,
-0.03916550427675247,
0.022091001272201538,
-0.015325631946325302,
-0.03253820165991783,
0.008197832852602005,
-0.03437912091612816,
-0.03617401421070099,
0.0024305854458361864,
0.008813388645648956,
-0.012518233619630337,
-0.019076500087976456,
-0.017327629029750824,
0.024231066927313805,
-0.01922607421875,
0.031180527061223984,
-0.02489839866757393,
-0.0015072505921125412,
0.02485237643122673,
0.043491657823324203,
0.0590013824403286,
-0.02740664780139923,
0.02717653289437294,
-0.01256425678730011,
-0.014566253870725632,
0.006765368860214949,
0.015141540206968784,
0.010602530092000961,
-0.011672562919557095,
0.01824808679521084,
0.013530737720429897,
0.07308439165353775,
0.007818142883479595,
0.025565730407834053,
-0.015314126387238503,
0.004472852218896151,
0.035046450793743134,
0.012610279954969883,
-0.02205648459494114,
-0.010706081055104733,
0.0050107454881072044,
-0.025312604382634163,
0.002167391823604703,
-0.034264061599969864,
-0.036012932658195496,
0.01254124566912651,
0.006443208549171686,
0.009198830462992191,
0.016545239835977554,
0.007099035196006298,
0.014934437349438667,
0.011839395388960838,
-0.008905434980988503,
-0.045033425092697144,
-0.00858327466994524,
-0.011942947283387184,
0.008157562464475632,
-0.008433699607849121,
-0.0064029386267066,
-0.029155518859624863,
-0.029569724574685097,
0.028258072212338448,
0.03665725514292717,
0.015037988312542439,
-0.002965601859614253,
0.03681833669543266,
-0.029155518859624863,
-0.033435650169849396,
-0.020595256239175797,
0.006109542679041624,
0.009319640696048737,
-0.0192605908960104,
0.006184329744428396,
-0.013047497719526291,
-0.026256075128912926,
0.0035408881958574057,
0.0022335497196763754,
0.01154024712741375,
0.0537547692656517,
0.0012721022358164191,
0.007317644078284502,
-0.014370656572282314,
0.0003444527683313936,
-0.025059478357434273,
-0.0022853256668895483,
0.04947463795542717,
0.02104398049414158,
-0.02409299835562706,
0.060336045920848846,
-0.01741967536509037,
-0.01922607421875,
-0.0009722341783344746,
-0.017235582694411278,
-0.010550754144787788,
-0.02331060916185379,
-0.006541007198393345,
0.026325110346078873,
-0.03647316247224808,
-0.051637716591358185,
-0.004907193593680859,
-0.006581277586519718,
0.0192720964550972,
-0.024553226307034492,
-0.045010413974523544,
-0.004349165596067905,
-0.03511548787355423,
0.03026006929576397,
0.031870871782302856,
0.019824372604489326,
0.02540465071797371,
-0.03792288526892662,
0.03104245848953724,
0.0076398043893277645,
-0.0333896279335022,
-0.01873132772743702,
0.014934437349438667,
-0.015164551325142384,
0.007996481843292713,
0.0062936339527368546,
-0.023977940902113914,
-0.03180183842778206,
-0.05490534380078316,
-0.0033251559361815453,
-0.009578519500792027,
-0.0053961873054504395,
-0.017097514122724533,
-0.007225598208606243,
0.008554509840905666,
0.022194553166627884,
0.010079018771648407,
0.012759854085743427,
-0.03481633961200714,
-0.02386288344860077,
0.005076903384178877,
-0.02538163959980011,
-0.007720344699919224,
0.02669329196214676,
-0.00691494345664978,
0.013105026446282864,
-0.0031583227682858706,
-0.00048575751134194434,
0.005706842057406902,
0.0027067228220403194,
-0.012978463433682919,
0.004081657622009516,
-0.0011182130547240376,
-0.016211573034524918,
-0.00120378693100065,
0.026302097365260124,
-0.026325110346078873,
-0.019663292914628983,
-0.02386288344860077,
0.023184046149253845,
-0.01691342331469059,
0.008387677371501923,
-0.018282605335116386,
0.028925403952598572,
0.020112015306949615,
-0.06355764716863632,
-0.015544240362942219,
0.00857752189040184,
0.010729093104600906,
-0.014117530547082424,
0.01798345521092415,
-0.046828318387269974,
-0.036035943776369095,
0.01449721958488226,
-0.012771359644830227,
0.010211335495114326,
-0.008100033737719059,
-0.005623425357043743,
0.0059081921353936195,
0.0006669727736152709,
-0.03311349079012871,
-0.0032532450277358294,
-0.05071725696325302,
-0.01790291629731655,
0.02358674630522728,
0.003399943234398961,
0.02719954587519169,
-0.022712310776114464,
0.04040812328457832,
-0.010855656117200851,
-0.010015737265348434,
-0.012380165047943592,
-0.020388152450323105,
-0.05927751958370209,
-0.019398659467697144,
-0.006569771561771631,
0.03605895861983299,
-0.03718651831150055,
0.04128255695104599,
-0.009423192590475082,
-0.03104245848953724,
0.025036467239260674,
-0.01999695785343647,
-0.001056369859725237,
-0.017316123470664024,
0.007979223504662514,
0.01257576234638691,
0.029109496623277664,
0.0025945419911295176,
-0.018305616453289986,
-0.020181050524115562,
-0.02745267190039158,
-0.007576522883027792,
0.018524223938584328,
-0.010429943911731243,
0.006644559092819691,
-0.02593391388654709,
-0.041903868317604065,
0.0035408881958574057,
0.02332211472094059,
-0.032193031162023544,
-0.018087007105350494,
0.043974898755550385,
0.014370656572282314,
0.01567080430686474,
-0.020595256239175797,
0.028096992522478104,
0.03456321358680725,
-0.013783863745629787,
-0.020353635773062706,
-0.02356373518705368,
-0.010090525262057781,
0.031088480725884438,
-0.0256117545068264,
0.03286036476492882,
-0.016510721296072006,
0.016280608251690865,
-0.026532212272286415,
0.0332515574991703,
-0.0031439405865967274,
0.008209338411688805,
-0.024484192952513695,
-0.006236105691641569,
-0.004211097024381161,
0.024415157735347748,
-0.04052317887544632,
-0.04231807217001915,
-0.0004681393620558083,
-0.0028088362887501717,
-0.015026482753455639,
-0.01485389657318592,
0.0015791613841429353,
0.006753863301128149,
0.027866877615451813,
0.0015633410075679421,
-0.023483194410800934,
-0.018869396299123764,
-0.012483716942369938,
-0.005378928501158953,
-0.004631055984646082,
-0.011010983027517796,
0.0022306733299046755,
0.0029771076515316963,
0.0019329625647515059,
-0.021136024966835976,
0.032147008925676346,
-0.02334512583911419,
-0.005994485225528479,
-0.03463224694132805,
-0.029316598549485207,
-0.010044502094388008,
-0.0006169947446323931,
0.002035076031461358,
0.001659701461903751,
-0.024507204070687294,
0.03785385191440582,
-0.0010031558340415359,
0.021159036085009575,
-0.02897142805159092,
0.0021069867070764303,
0.006466220133006573,
0.030098989605903625,
0.015141540206968784,
0.024484192952513695,
-0.011638045310974121,
0.06769971549510956,
-0.004323278088122606,
0.0009600093471817672,
-0.03953368589282036,
-0.00532139977440238,
0.014819379895925522,
0.0231035053730011,
0.026210052892565727,
-0.00724860979244113,
0.01689041033387184,
0.01180487871170044,
0.0038199021946638823,
0.01766129583120346,
0.006241858471184969,
0.00044368969975039363,
0.03490838408470154,
0.006425950210541487,
0.03939561918377876,
-0.005775876343250275,
0.011120287701487541,
0.01113754604011774,
-0.012023487128317356,
-0.011402178555727005,
-0.02667028084397316,
0.04275529086589813,
-0.007530500181019306,
-0.038083966821432114,
0.008663814514875412,
0.012943945825099945,
0.008640803396701813,
0.00807702261954546,
0.035529691725969315,
0.03437912091612816,
0.07340655475854874,
0.002380247926339507,
0.01548671256750822,
0.027291590347886086,
-0.000601893465500325,
-0.031410641968250275,
0.03490838408470154,
-0.04772576689720154,
0.06185480207204819,
-0.010660058818757534,
-0.010763609781861305,
0.0030375125352293253,
-0.011643798090517521,
-0.003307897364720702,
0.005376052111387253,
0.0359669104218483,
0.042433131486177444,
-0.00043254351476207376,
-0.03980982303619385,
0.056286029517650604,
-0.012380165047943592,
-0.014934437349438667,
0.01064279954880476,
0.01638415828347206,
0.006115295458585024,
0.019640279933810234,
0.020100509747862816,
-0.032400134950876236,
-0.014370656572282314,
0.0070875296369194984,
0.04284733906388283,
0.029845863580703735,
-0.036012932658195496,
-0.008278372697532177,
0.002547080861404538,
0.005148814059793949,
-0.020687302574515343,
-0.01155175268650055,
-0.01305900327861309,
0.0037422385066747665,
0.046230021864175797,
-0.0053472877480089664,
-0.028626255691051483,
-0.0036099227145314217,
0.020802360028028488,
-0.030697286128997803,
-0.03785385191440582,
-0.04570075869560242,
0.04438910633325577,
0.03511548787355423,
-0.02975381724536419,
-0.002604609588161111,
0.026808349415659904,
-0.008065516129136086,
-0.06323549151420593,
-0.02793591096997261,
0.030191034078598022,
0.003307897364720702,
0.051913853734731674,
-0.03714049607515335,
0.006368421483784914,
0.015958447009325027,
0.00792744755744934,
0.008174820803105831,
0.010815385729074478,
-0.039579711854457855,
0.008370418101549149,
-0.024737318977713585,
-0.0332745686173439,
-0.008128797635436058,
-0.005977226421236992,
-0.01615404523909092,
-0.01014230027794838,
0.04721951484680176,
0.023425664752721786,
-0.011724338866770267,
0.0019976822659373283,
-0.009699329733848572,
0.028096992522478104,
0.021849380806088448,
0.009710836224257946,
0.011258356273174286,
0.0010304818861186504,
-0.006218846887350082,
-0.02182636968791485,
0.013438692316412926,
-0.011425189673900604,
0.06001388654112816,
0.021734323352575302,
0.013622784055769444,
-0.045769792050123215,
-0.026739316061139107,
0.017224077135324478,
0.0487382709980011,
-0.024668283760547638,
-0.013162555173039436,
-0.02874131314456463,
0.0006766807055100799,
0.019893405959010124,
0.03203194960951805,
0.03495440632104874,
0.05476727336645126,
0.007202586624771357,
0.008289878256618977,
0.01178186759352684,
0.022102506831288338,
0.010159559547901154,
0.0034689775202423334,
-0.005260995123535395,
-0.006644559092819691,
0.013898921199142933,
0.035529691725969315,
-0.00858902744948864,
0.010510483756661415,
-0.03460923582315445,
0.008456711657345295,
0.035989921540021896,
0.01305900327861309,
0.02897142805159092,
-0.026486190035939217,
0.013035992160439491,
0.0230689886957407,
-0.030927401036024094,
-0.008554509840905666,
-0.03099643625319004,
-0.028396140784025192,
-0.014508725143969059,
-0.005143061280250549,
0.006937955040484667,
-0.01591242477297783,
0.0032072220928967,
-0.002804521704092622,
0.017051491886377335,
-0.04659820348024368,
-0.0072946324944496155,
-0.0075592645443975925,
-0.03697941452264786,
-0.011517235077917576,
-0.00807702261954546,
-0.026808349415659904,
0.007818142883479595,
-0.01819055899977684,
-0.03196291625499725,
0.019571246579289436,
0.01721257157623768,
-0.00935991108417511,
-0.004973351489752531,
-0.003929206635802984,
0.021389150992035866,
-0.016246089711785316,
-0.017534732818603516,
0.013427186757326126,
-0.018593259155750275,
-0.013427186757326126,
-0.05274226516485214,
0.04229506105184555,
0.009285124018788338,
-0.04491836950182915,
0.01892692595720291,
0.014876908622682095,
-0.004113298375159502,
0.040362101048231125,
-0.009400181472301483,
-0.004153568297624588,
0.022631769999861717,
0.012759854085743427,
0.014715828001499176,
-0.0005037352093495429,
0.007093282416462898,
0.012633291073143482,
-0.009411687031388283,
-0.023253079503774643,
0.006121048238128424,
0.000683512247633189,
0.0032503686379641294,
-0.02021556720137596,
-0.052926357835531235,
0.023011459037661552,
0.00454476336017251,
0.007018494885414839,
-0.0029799840413033962,
0.01305900327861309,
-0.003310773754492402,
-0.012092522345483303,
0.0032705035991966724,
0.006719346158206463,
0.0192490853369236,
-0.020710313692688942,
0.011862407438457012,
0.0024305854458361864,
0.001475609838962555,
0.024185044690966606,
-0.01449721958488226,
-0.006575524341315031,
0.015302620828151703,
-0.004208220634609461,
-0.01999695785343647,
0.05182180553674698,
-0.023931916803121567,
-0.04744962975382805,
0.02533561736345291,
0.004133433569222689,
-0.022608758881688118,
-0.005413445644080639,
0.04519450664520264,
-0.019111016765236855,
0.007731850259006023,
-0.010176817886531353,
0.027544716373085976,
0.03479332476854324,
-0.014025484211742878,
0.02406998723745346,
0.004142062738537788,
-0.01693643443286419,
-0.0058305286802351475,
-0.0007593781338073313,
-0.006851661950349808,
0.0009233347955159843,
0.016246089711785316,
-0.042640235275030136,
-0.010579518042504787,
-0.020100509747862816,
0.02201046049594879,
0.03969476744532585,
-0.00044189192703925073,
-0.017039986327290535,
0.035506680607795715,
-0.02097494527697563,
0.009204584173858166,
-0.025013456121087074,
-0.016257595270872116,
-0.008974469266831875,
-0.011108782142400742,
-0.03794589638710022,
-0.007547758519649506,
0.00666757021099329,
0.000446566118625924,
0.015463700518012047,
-0.0015014976961538196,
0.011557505466043949,
0.005203466396778822,
-0.03700242564082146,
-0.001255562761798501,
-0.010096278041601181,
0.014278610236942768,
-0.012357153929769993,
-0.006195835303515196,
-0.03718651831150055,
-0.02105548605322838,
0.02894841507077217,
-0.0032072220928967,
-0.013116532005369663,
0.018317122012376785,
0.022401655092835426,
0.0256577767431736,
0.015739837661385536,
0.02022707276046276,
-0.01087866723537445,
0.009204584173858166,
-0.03971777856349945,
0.026578236371278763,
-0.03640412911772728,
0.008997480385005474,
0.00776061462238431,
-0.0192490853369236,
-0.044228024780750275,
-0.0019444683566689491,
0.005764370784163475,
-0.00505389180034399,
0.02388589456677437,
0.015061000362038612,
-0.016073504462838173,
-0.014267104677855968,
0.0019948058761656284,
0.018294110894203186,
-0.006788380444049835,
-0.0011901239631697536,
0.00048144286847673357,
-0.0007101192604750395,
0.00531852338463068,
-0.01591242477297783,
-0.025473685935139656,
0.0035610233899205923,
-0.00024359786766581237,
-0.006276375614106655,
-0.010470214299857616,
0.020560739561915398,
-0.0036674514412879944,
0.00029591299244202673,
0.008658061735332012,
0.005540008656680584,
0.0034517189487814903,
-0.03762373700737953,
-0.034517187625169754,
-0.0009449080680496991,
0.017799364402890205,
0.0075995344668626785,
0.016982456669211388,
0.023954929783940315,
-0.04130556806921959,
-0.009929444640874863,
-0.03875129669904709,
0.020100509747862816,
-0.018098512664437294,
-0.008422194048762321,
0.020652784034609795,
0.01102824229747057,
-0.03566776216030121,
0.005554391071200371,
0.0017618148121982813,
0.00032108178129419684,
0.026256075128912926,
0.008681072853505611,
-0.001786264474503696,
0.0006935797864571214,
-0.011499976739287376,
-0.006558266002684832,
0.012656302191317081,
0.014865403063595295,
0.023954929783940315,
-0.013530737720429897,
-0.01739666238427162,
-0.019283602014183998,
0.03622003644704819,
0.021136024966835976,
0.01969780959188938,
-0.016706319525837898,
-0.03663424402475357,
0.009480721317231655,
-0.0018351639155298471,
0.006224599666893482,
-0.007357914000749588,
0.02644016593694687,
-0.016579756513237953,
-0.019364142790436745,
0.036772310733795166,
0.00666757021099329,
-0.015716826543211937,
-0.00045807185233570635,
-0.0056924596428871155,
0.003290638793259859,
-0.02000846341252327,
-0.010700328275561333,
0.008169068023562431,
-0.022401655092835426,
-0.0020307612139731646,
0.007127799559384584,
-0.009687824174761772,
-0.021998954936861992,
0.0001370799873257056,
-0.02644016593694687,
0.006098036654293537,
-0.0038083966355770826,
-0.046529170125722885,
-0.07727248221635818,
0.01845519058406353,
0.006207341328263283,
-0.00750748859718442,
0.008059763349592686,
-0.022643275558948517,
0.020353635773062706,
0.03431008756160736,
-0.020940428599715233,
0.02388589456677437,
0.04749565199017525,
0.018823374062776566,
0.013956449925899506,
0.011200827546417713,
0.020595256239175797,
0.005117173306643963,
-0.030444160103797913,
-0.0011210895609110594,
-0.023724814876914024,
-0.0025643394328653812,
0.026210052892565727,
-0.024714307859539986,
0.0012275174958631396,
0.03228507563471794,
0.0035754055716097355,
0.010401180014014244,
-0.006132553797215223,
-0.01871982216835022,
0.038060951977968216,
-0.009969715029001236,
-0.0011318761389702559,
-0.004527504555881023,
-0.021975943818688393,
-0.010660058818757534,
0.013611278496682644,
0.01088442001491785,
-0.029017450287938118,
-0.009244853630661964,
0.007921694777905941,
0.030950412154197693,
-0.03536861389875412,
-0.010602530092000961,
0.02616402879357338,
0.0230574831366539,
-0.003100794041529298,
0.010038749314844608,
0.017891408875584602,
-0.026854373514652252,
-0.027337614446878433,
0.0006874673417769372,
0.020181050524115562,
-0.014301622286438942,
0.025266582146286964,
0.011154805310070515,
-0.03000694327056408,
0.017638282850384712,
0.005079779773950577,
-0.005281129851937294,
-0.0048180241137743,
-0.030628252774477005,
-0.012334141880273819,
-0.03078933246433735,
-0.007628298830240965,
-0.018063995987176895,
-0.021343128755688667,
-0.009785623289644718,
0.012207578867673874,
-0.03078933246433735,
0.02336813695728779,
0.003351043676957488,
0.0038371607661247253,
0.006241858471184969,
0.00033258748590014875,
-0.013496221043169498,
0.011304379440844059,
-0.028050968423485756,
0.028096992522478104,
-0.00019469851395115256,
-0.01946769468486309,
-0.021136024966835976,
-0.016706319525837898,
0.030904389917850494,
-0.0055227503180503845,
-0.038820333778858185,
-0.004608044866472483,
-0.0047806305810809135,
-0.022884896025061607,
0.018374649807810783,
0.029868874698877335,
-0.012495222501456738,
0.011505729518830776,
-0.017120525240898132,
0.0007158720982261002,
0.0047835069708526134,
0.02130861207842827,
-0.012368659488856792,
-0.012276613153517246,
-0.021170543506741524,
-0.010165312327444553,
-0.010573765262961388,
-0.03546065837144852,
-0.026279086247086525,
0.004748989827930927,
-0.031364619731903076,
0.006098036654293537,
0.02669329196214676,
-0.005327153019607067,
-0.015682309865951538,
0.030052965506911278,
-0.047265537083148956,
0.00506252096965909,
-0.015429183840751648,
0.01449721958488226,
0.02996091917157173,
0.028373129665851593,
-0.03046717308461666,
0.01334664598107338,
0.008203585632145405,
0.014060001820325851,
-0.026831362396478653,
-0.027981935068964958,
0.036243047565221786,
-0.019168546423316002,
-0.02073332481086254,
0.020583750680088997,
0.011758855544030666,
-0.022666286677122116,
0.006753863301128149,
-0.01973232626914978,
-0.019064994528889656,
0.020882898941636086,
-0.05076327919960022,
0.011430942453444004,
-0.004912946373224258,
0.008939951658248901,
-0.00666757021099329,
-0.001147696515545249,
-0.03417201712727547,
-0.006270622834563255,
-0.04892236366868019,
-0.014899919740855694,
-0.008755859918892384,
-0.009894927963614464,
-0.04303142800927162,
0.030168022960424423,
0.012380165047943592,
0.015808872878551483,
0.04077630490064621,
0.018305616453289986,
-0.01010778360068798,
0.03230809047818184,
-0.00987766869366169,
-0.030421148985624313,
0.007674321532249451,
-0.024415157735347748,
0.01815604232251644,
0.020399658009409904,
0.018880901858210564,
-0.0281890369951725,
0.03569077327847481,
0.03976380079984665,
-0.020836876705288887,
-0.009682071395218372,
-0.0166602972894907,
-0.007093282416462898,
-0.008013741113245487,
-0.014543242752552032,
0.08316341042518616,
-0.024300100281834602,
-0.00240901205688715,
0.007691580336540937,
-0.015141540206968784,
-0.013967955484986305,
0.011827889829874039,
-0.0010678755352273583,
0.033458661288022995,
-0.027613751590251923,
0.03750867769122124,
0.012518233619630337,
0.042180005460977554,
0.026601247489452362,
0.05329453945159912,
-0.0028476680163294077,
0.016970951110124588,
0.03205496445298195,
-0.022758333012461662,
-0.030950412154197693,
-0.0017575002275407314,
0.02411600947380066,
0.007053012493997812,
0.05610193684697151,
-0.015843389555811882,
-0.0010570889571681619,
-0.0035754055716097355,
-0.006960966624319553,
-0.01331212930381298,
-0.010947701521217823,
0.007329149637371302,
0.02388589456677437,
0.02874131314456463,
-0.03106546960771084,
0.021975943818688393,
-0.017373651266098022,
-0.020836876705288887,
-0.01409451849758625,
-0.010021490976214409,
-0.00910678505897522,
-0.00134760863147676,
0.004205344244837761,
-0.0034862360917031765,
-0.01766129583120346,
0.01944468356668949,
-0.004116174764931202,
-0.02487538754940033,
-0.002818903885781765,
0.012334141880273819,
0.011241097934544086,
0.02413902059197426,
0.0029210171196609735,
0.018052490428090096,
-0.005508367903530598,
-0.04183483123779297,
-0.006201588083058596,
0.023276090621948242,
-0.010976466350257397,
0.0010412685805931687,
-0.044435128569602966,
-0.0383601039648056,
0.022148529067635536,
0.023724814876914024,
-0.009492226876318455,
-0.00885941181331873
] | 2025-01-12 | 1 | 39798230 | [
"T cell",
"T cell exhaustion",
"CAR-T cell therapy",
"universal CAR platforms",
"metastatic breast cancer",
"CAR-T cells",
"antigen escape",
"Possible approaches",
"armored CARs",
"breast cancer",
"antigen",
"CAR",
"BC therapy",
"chemokine receptor engineering",
"hematological cancers",
"therapeutic applicability",
"breast malignancies",
"inducible gene switches",
"metastatic progression",
"possible strategies",
"conventional treatments",
"BC",
"external triggers",
"synthetic biology",
"manufacturing processes",
"tumor-specific antigens",
"safety",
"particularly chimeric antigen receptor-engineered T (CAR-T) cells",
"current outcomes",
"a promising experimental approach"
] | [
"Breast cancer",
"CAR",
"Clinical trial",
"Immunotherapy",
"T cell",
"Tumor antigen"
] | 0 | 10.1016/j.ctrv.2024.102868 | [
"Buono",
"Capozzi",
"Caputo",
"Lauro",
"Cianniello",
"Piezzo",
"Cocco",
"Martinelli",
"Verrazzo",
"Tafuro",
"Calderaio",
"Calabrese",
"Nuzzo",
"Pagliuca",
"Laurentiis"
] | [
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale (SSM), Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale (SSM), Napoli, Italy.",
"Clinical and Translational Oncology, Scuola Superiore Meridionale (SSM), Napoli, Italy; Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.",
"Clinical and Translational Oncology, Scuola Superiore Meridionale (SSM), Napoli, Italy; Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy.",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy; Clinical and Translational Oncology, Scuola Superiore Meridionale (SSM), Napoli, Italy; Université Paris-Saclay, Gustave Roussy, INSERM, Molecular Predictors and New Targets in Oncology, Villejuif, France. Electronic address: [email protected].",
"Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, Napoli, Italy. Electronic address: [email protected]."
] | [
"39798230"
] | [] | 10.293876 | 4.331953 |
39798090 | 42 | Tumor-induced metabolic immunosuppression: Mechanisms and therapeutic targets. | Metabolic reprogramming in both immune and cancer cells plays a crucial role in the antitumor immune response. Recent studies indicate that cancer metabolism not only sustains carcinogenesis and survival via altered signaling but also modulates immune cell function. Metabolic crosstalk within the tumor microenvironment results in nutrient competition and acidosis, thereby hindering immune cell functionality. Interestingly, immune cells also undergo metabolic reprogramming that enables their proliferation, differentiation, and effector functions. This review highlights the regulation of antitumor immune responses through metabolic reprogramming in cancer and immune cells and explores therapeutic strategies that target these metabolic pathways in cancer immunotherapy, including using chimeric antigen receptor (CAR)-T cells. We discuss innovative combinations of immunotherapy, cellular therapies, and metabolic interventions that could optimize the efficacy of existing treatment protocols. | [
0.011872739531099796,
0.018889930099248886,
0.0411037914454937,
0.043602172285318375,
-0.033261049538850784,
0.024940356612205505,
0.03769296035170555,
0.04966346174478531,
-0.005936369765549898,
-0.011052618734538555,
-0.02268095128238201,
-0.03486870229244232,
-0.0036905426532030106,
0.045535702258348465,
0.024657929316163063,
-0.03284827247262001,
0.038040559738874435,
0.017890578135848045,
0.0160982608795166,
0.042711444199085236,
0.013512980192899704,
-0.02121450938284397,
-0.007229010108858347,
-0.007000897079706192,
-0.04875100776553154,
0.0013055396266281605,
-0.00803826842457056,
-0.009260302409529686,
0.016760874539613724,
0.01170980092138052,
0.026048332452774048,
-0.014349394477903843,
-0.029307089745998383,
-0.019519956782460213,
-0.025657283142209053,
-0.022203000262379646,
0.008255518041551113,
-0.040756192058324814,
0.009189695119857788,
-0.0016470302361994982,
-0.002188798738643527,
0.021540386602282524,
0.0032316010911017656,
0.09863171726465225,
-0.0467088557779789,
-0.0011874097399413586,
-0.02265922538936138,
-0.08611809462308884,
0.017619013786315918,
0.00027835217770189047,
-0.04331974685192108,
0.02441895380616188,
0.002425058512017131,
0.03017609193921089,
-0.06191638857126236,
0.02337615191936493,
-0.013838855549693108,
0.01505545899271965,
-0.011481688357889652,
0.02017170749604702,
0.005341646261513233,
0.020421545952558517,
0.03741053491830826,
0.00701719056814909,
-0.09272250533103943,
0.0012960348976776004,
-0.007945936173200607,
-0.02444067969918251,
0.009396083652973175,
-0.01796661503612995,
0.020475858822464943,
-0.01741262711584568,
0.009819721803069115,
0.04334147274494171,
0.038931287825107574,
-0.02826428785920143,
-0.015153221786022186,
0.0009606545208953321,
-0.02068224549293518,
-0.032500673085451126,
0.020454132929444313,
-0.03171857073903084,
0.05452987179160118,
-0.0310450941324234,
-0.015826698392629623,
0.02911156602203846,
0.023941002786159515,
-0.02991539239883423,
-0.07794947177171707,
0.004133190494030714,
0.02617868408560753,
0.0033185011707246304,
-0.025961432605981827,
0.04523155093193054,
0.024723105132579803,
0.015544272027909756,
-0.025765907019376755,
-0.053921569138765335,
0.038953013718128204,
0.055876825004816055,
0.055876825004816055,
-0.018574915826320648,
-0.007739548571407795,
-0.007522298023104668,
0.0401696152985096,
-0.023267526179552078,
-0.021377447992563248,
-0.014740445651113987,
0.05040211230516434,
0.016869500279426575,
0.07134506106376648,
0.000020399056666065007,
0.013013304211199284,
0.0035927798599004745,
-0.04766475781798363,
-0.05748447775840759,
-0.03187064453959465,
0.013219691812992096,
0.012915541417896748,
0.027590811252593994,
0.0002841229143086821,
0.03489042818546295,
-0.012111715041100979,
-0.037823308259248734,
0.019498230889439583,
-0.06308954209089279,
0.06617449969053268,
-0.030393343418836594,
-0.02639593370258808,
-0.011883601546287537,
0.011123225092887878,
-0.00912995170801878,
0.017293138429522514,
-0.002401975682005286,
-0.06573999673128128,
-0.04158174246549606,
-0.02212696149945259,
0.004505231976509094,
0.0026328042149543762,
-0.0033130699303001165,
0.022159550338983536,
0.005871194414794445,
-0.0034189794678241014,
0.006452339235693216,
-0.06100393831729889,
-0.07130160927772522,
0.02539658173918724,
0.047534406185150146,
-0.001716278842650354,
0.04770820587873459,
0.00315284775570035,
0.01601136103272438,
0.043602172285318375,
0.015609447844326496,
0.01605481095612049,
-0.021225372329354286,
0.030458517372608185,
0.05826658010482788,
-0.018965966999530792,
-0.032261695712804794,
-0.025005530565977097,
-0.0021317703649401665,
-0.003275051014497876,
-0.0301109179854393,
-0.012893816456198692,
-0.02265922538936138,
-0.03869231045246124,
0.06269849091768265,
-0.04618745297193527,
0.004247246775776148,
-0.037953659892082214,
-0.06104738637804985,
-0.028677064925432205,
-0.025548657402396202,
-0.04523155093193054,
0.005200433544814587,
-0.011937914416193962,
-0.0033130699303001165,
0.005322637036442757,
0.053834669291973114,
0.0008819011854939163,
-0.001674186554737389,
0.012003089301288128,
0.008070855401456356,
-0.00419293437153101,
-0.0007888908148743212,
-0.03919198736548424,
0.036107029765844345,
-0.046578504145145416,
0.00024814080097712576,
-0.0009328192682005465,
0.017890578135848045,
0.03019781783223152,
0.012470178306102753,
-0.0326961986720562,
-0.001826261868700385,
0.04227694496512413,
0.022898200899362564,
-0.03788848593831062,
0.004133190494030714,
0.027808062732219696,
-0.011362200602889061,
0.0025363995227962732,
-0.005985250696539879,
-0.015305296517908573,
-0.0005047679296694696,
-0.027742886915802956,
-0.00276043894700706,
0.00859768781810999,
0.049402762204408646,
0.018824754282832146,
-0.001424348447471857,
-0.006121032405644655,
0.032500673085451126,
0.008521649986505508,
-0.03187064453959465,
-0.019519956782460213,
0.016804324463009834,
0.020834321156144142,
0.011601176112890244,
0.0030333600006997585,
-0.012187751941382885,
0.02541830763220787,
0.009108226746320724,
-0.013274004682898521,
0.003247894812375307,
-0.017249688506126404,
-0.00958617776632309,
0.00431513786315918,
-0.0013917608885094523,
0.0035140265244990587,
0.018053514882922173,
0.0206605214625597,
-0.028763964772224426,
-0.021344861015677452,
-0.021366585046052933,
-0.018933380022644997,
-0.03087129443883896,
0.03688913211226463,
-0.03089301846921444,
0.01836852915585041,
0.02257232554256916,
0.008635707199573517,
-0.0021385594736784697,
-0.04709990695118904,
0.03630255535244942,
0.0001156689104391262,
-0.049315858632326126,
-0.014805620536208153,
-0.007750411052256823,
-0.04605710133910179,
0.04121241718530655,
0.010471473447978497,
0.0025146743282675743,
0.011753251776099205,
-0.00896158255636692,
0.04305904731154442,
-0.009178833104670048,
0.030306443572044373,
-0.011275299824774265,
-0.014957696199417114,
0.021866261959075928,
-0.018031790852546692,
-0.05148836597800255,
-0.0321965217590332,
0.007087796926498413,
-0.007190991193056107,
0.01224206481128931,
0.019498230889439583,
-0.03193582221865654,
0.03940923884510994,
0.01592446118593216,
0.026721809059381485,
-0.024853454902768135,
-0.0060449945740401745,
0.052270468324422836,
0.016337236389517784,
0.05283531919121742,
-0.0010414444841444492,
-0.004214659333229065,
0.006685883738100529,
-0.027981862425804138,
0.01357815507799387,
-0.016597937792539597,
-0.023962728679180145,
0.0029410284478217363,
0.005175992846488953,
0.024071354418992996,
0.029806766659021378,
-0.038953013718128204,
-0.023875828832387924,
0.0034977328032255173,
-0.012720015831291676,
-0.01273087877780199,
0.010721311904489994,
0.010705017484724522,
-0.00018279592040926218,
-0.05174906551837921,
-0.03373900055885315,
0.03386935219168663,
-0.005588768981397152,
-0.0018181150080636144,
-0.06391509622335434,
-0.06456684321165085,
0.02359340339899063,
0.003351088846102357,
0.000691128137987107,
-0.011753251776099205,
0.038170911371707916,
0.04705645516514778,
0.03263102471828461,
-0.003698689630255103,
0.04047376662492752,
-0.0012267862912267447,
-0.013784543611109257,
0.01981324516236782,
0.028850864619016647,
-0.04875100776553154,
0.029567791149020195,
-0.016152573749423027,
-0.0326961986720562,
-0.0022729833144694567,
-0.032500673085451126,
0.0009301036479882896,
0.013665055856108665,
-0.018053514882922173,
0.010020678862929344,
0.013730230741202831,
0.023767203092575073,
-0.009401515126228333,
0.029589517042040825,
-0.015033734031021595,
0.06391509622335434,
0.002123623387888074,
0.01414300687611103,
0.005279186647385359,
-0.024853454902768135,
0.008092580363154411,
0.025874532759189606,
0.023919278755784035,
-0.0051841395907104015,
-0.013914893381297588,
-0.05096696317195892,
0.007533160503953695,
-0.009700234048068523,
-0.011753251776099205,
-0.011557726189494133,
0.015848422423005104,
-0.019204942509531975,
0.01736917719244957,
0.04034341499209404,
0.03558563068509102,
-0.0014379266649484634,
-0.0019919152837246656,
-0.01736917719244957,
0.028677064925432205,
0.007826448418200016,
-0.013665055856108665,
0.03847506269812584,
-0.0026776122394949198,
0.024027904495596886,
-0.023702027276158333,
-0.013708505779504776,
0.030306443572044373,
0.06169913709163666,
0.030436793342232704,
-0.03597668185830116,
-0.011112362146377563,
-0.03160994499921799,
-0.03473835438489914,
-0.02919846586883068,
0.03267447277903557,
0.02524450607597828,
-0.012643977999687195,
-0.04944621026515961,
0.03280482441186905,
-0.00460299476981163,
0.001240364508703351,
0.022767851129174232,
-0.0021290548611432314,
0.06017838418483734,
0.01934615522623062,
0.006859683897346258,
0.0007583400001749396,
-0.013632467947900295,
0.014577507972717285,
0.03845333680510521,
-0.02724321186542511,
-0.09202730655670166,
-0.002666749758645892,
0.013219691812992096,
-0.04792545735836029,
-0.011861876584589481,
0.0025391150265932083,
0.01262225303798914,
0.02528795599937439,
-0.011275299824774265,
0.03775813430547714,
0.04043031483888626,
0.022854750975966454,
0.019889282062649727,
-0.019422193989157677,
-0.037931933999061584,
-0.04421047493815422,
-0.0050727990455925465,
-0.033282775431871414,
0.03823608532547951,
-0.00013518751075025648,
0.0691291019320488,
0.018574915826320648,
-0.017673326656222343,
-0.017130201682448387,
0.01312192901968956,
0.016152573749423027,
-0.007706961128860712,
-0.051314566284418106,
-0.04583985358476639,
0.016337236389517784,
0.03380417451262474,
-0.004727913532406092,
0.02900294028222561,
-0.010047835297882557,
0.02448412962257862,
-0.01741262711584568,
-0.00023558099928777665,
0.019443918019533157,
0.051227666437625885,
-0.03680223226547241,
-0.01683691330254078,
-0.06500134617090225,
-0.04966346174478531,
0.042515918612480164,
-0.0021779360249638557,
-0.022246450185775757,
-0.0020706686191260815,
0.03732363507151604,
0.01265484094619751,
-0.018976829946041107,
-0.018249040469527245,
0.0003879957948811352,
-0.04762130603194237,
0.028698788955807686,
-0.02350650355219841,
-0.040886539965867996,
0.013632467947900295,
0.04992416128516197,
0.01743435114622116,
0.030349893495440483,
0.033847626298666,
-0.023137176409363747,
0.03762778267264366,
-0.02717803604900837,
0.009466690011322498,
0.008163186721503735,
-0.02722148597240448,
0.0010923625668510795,
0.00007183692650869489,
-0.02333270199596882,
0.03725845739245415,
0.01132961269468069,
0.03754088282585144,
-0.019074592739343643,
0.007880761288106441,
-0.037193283438682556,
0.015891872346401215,
0.06200328841805458,
0.05665892735123634,
0.027612537145614624,
-0.010487766936421394,
-0.03215307369828224,
0.04345009848475456,
-0.021605560556054115,
-0.026526283472776413,
0.01506632100790739,
0.011264437809586525,
-0.004537819419056177,
0.018129553645849228,
0.005116248968988657,
0.023680303245782852,
-0.0014338531764224172,
-0.00008248729136539623,
-0.026091784238815308,
-0.04570950195193291,
0.0331306979060173,
-0.013013304211199284,
-0.007315909955650568,
-0.054964374750852585,
-0.01409955695271492,
-0.012948129326105118,
0.025917982682585716,
-0.005032064393162727,
-0.016065673902630806,
0.01836852915585041,
-0.007451691664755344,
-0.022355075925588608,
-0.009265732951462269,
-0.018694404512643814,
0.005947232246398926,
0.0026681076269596815,
0.012633115984499454,
0.0006212005973793566,
0.003253326052799821,
0.007674373220652342,
-0.00004642031854018569,
0.051271114498376846,
0.02165987342596054,
0.05335671827197075,
0.07438656687736511,
0.0027224202640354633,
0.031414419412612915,
-0.01403438113629818,
-0.006734765134751797,
0.03191409632563591,
0.012676565907895565,
-0.04709990695118904,
0.006126463878899813,
-0.029372265562415123,
-0.03580287843942642,
0.021377447992563248,
0.011470825411379337,
0.00656096450984478,
-0.008657432161271572,
-0.0007739548454992473,
-0.0014338531764224172,
0.029546065255999565,
-0.044536348432302475,
-0.031240619719028473,
-0.001046875724568963,
-0.02904639020562172,
-0.040756192058324814,
-0.0026979795657098293,
-0.043515272438526154,
0.017640739679336548,
0.004488938022404909,
-0.0005624750629067421,
-0.02622213400900364,
-0.01411041896790266,
0.004141337238252163,
-0.014208181761205196,
-0.019096318632364273,
0.04053894057869911,
-0.005615924950689077,
0.0009620123310014606,
0.02526623196899891,
0.005037495866417885,
0.06096048653125763,
-0.02819911390542984,
-0.04238557070493698,
-0.00729961646720767,
-0.023984454572200775,
0.03862713649868965,
-0.034434203058481216,
0.006919427774846554,
-0.0022689097095280886,
0.00551544688642025,
0.002900294028222561,
0.0002325259119970724,
-0.04199451953172684,
-0.013817130587995052,
0.015294434502720833,
-0.03953958675265312,
-0.0007400094764307141,
0.001558772288262844,
-0.012111715041100979,
0.025874532759189606,
0.004160346928983927,
0.009787134826183319,
-0.01037371065467596,
-0.029654690995812416,
0.04327629506587982,
0.034347303211688995,
-0.012850366532802582,
-0.009749115444719791,
-0.04701300710439682,
0.046448152512311935,
-0.010237929411232471,
-0.03584633022546768,
-0.007413672748953104,
0.014827345497906208,
-0.0014039812376722693,
0.006229657679796219,
-0.014403707347810268,
0.004298843909054995,
0.019943594932556152,
-0.03256584703922272,
0.021627286449074745,
-0.0334131233394146,
-0.005458418279886246,
-0.007158403750509024,
-0.010645274072885513,
0.012459315359592438,
-0.011937914416193962,
0.014273356646299362,
0.009819721803069115,
-0.020204294472932816,
0.044536348432302475,
0.00934177078306675,
0.0010231139604002237,
-0.007902486249804497,
0.024744831025600433,
0.009526433423161507,
0.010520354844629765,
-0.017380038276314735,
-0.05357396975159645,
-0.05187941715121269,
0.044427722692489624,
0.005200433544814587,
-0.0029899098444730043,
0.0054041058756411076,
0.030371617525815964,
0.030480243265628815,
0.03940923884510994,
-0.05370432138442993,
-0.006468633189797401,
0.01581583544611931,
-0.0020068513695150614,
-0.001974263694137335,
-0.01585928536951542,
0.018357666209340096,
-0.0031392695382237434,
0.007245303597301245,
0.010476904921233654,
-0.032305147498846054,
-0.010199910029768944,
-0.0005000155651941895,
-0.06087358668446541,
-0.04408012330532074,
-0.026070058345794678,
0.004706188570708036,
0.004062584135681391,
0.016891226172447205,
-0.03019781783223152,
-0.007880761288106441,
0.0375843346118927,
0.001073353225365281,
-0.014794758521020412,
0.01174238882958889,
0.002160284435376525,
-0.008934426121413708,
0.007821017876267433,
0.012089989148080349,
-0.018401116132736206,
-0.0007277891272678971,
-0.04108206555247307,
0.02210523746907711,
-0.006180776283144951,
-0.04862065985798836,
-0.012296377681195736,
0.010677861049771309,
-0.021877123042941093,
0.014925108291208744,
-0.040886539965867996,
0.0037095521111041307,
0.007804723922163248,
-0.019400468096137047,
0.010270516388118267,
0.02908984012901783,
-0.02919846586883068,
0.041820719838142395,
0.033261049538850784,
-0.022061787545681,
-0.012752603739500046,
-0.014012656174600124,
0.007821017876267433,
-0.01792316511273384,
0.006148188840597868,
0.019248392432928085,
-0.0058168815448880196,
0.020475858822464943,
0.016380686312913895,
0.04119069129228592,
-0.01739090122282505,
0.038018833845853806,
-0.019443918019533157,
-0.008076286874711514,
0.04475359991192818,
0.044536348432302475,
-0.03547700494527817,
-0.03645463287830353,
-0.005268324166536331,
-0.00365252373740077,
-0.012926404364407063,
-0.0024644352961331606,
-0.02641765959560871,
0.0032071603927761316,
0.003495017299428582,
0.013860581442713737,
0.010982012376189232,
0.01095485594123602,
-0.013056754134595394,
0.01581583544611931,
-0.010058697313070297,
-0.028481539338827133,
-0.03953958675265312,
0.016174297779798508,
0.001436568796634674,
0.001975621562451124,
0.011438238434493542,
-0.02444067969918251,
-0.04627435281872749,
0.02106243371963501,
0.02112760953605175,
-0.00048677687300369143,
-0.024940356612205505,
0.03662843257188797,
-0.01874871738255024,
0.015718072652816772,
-0.010873386636376381,
0.0110308937728405,
-0.007375653833150864,
-0.030588869005441666,
-0.012915541417896748,
0.02268095128238201,
-0.00363351427949965,
0.013295729644596577,
0.007381085306406021,
-0.002949175424873829,
0.032457221299409866,
0.040908265858888626,
0.0017583711305633187,
-0.023962728679180145,
-0.012709153816103935,
0.0005193644319660962,
0.006446908228099346,
0.05348706990480423,
0.03495560213923454,
-0.025939708575606346,
0.05709342658519745,
-0.03102337010204792,
0.02257232554256916,
-0.0025608402211219072,
-0.03582460433244705,
-0.03208789601922035,
-0.023897552862763405,
-0.0017814539605751634,
0.030545419082045555,
-0.03360864892601967,
-0.05657202750444412,
-0.0008635706617496908,
0.004651876166462898,
-0.011106930673122406,
-0.04770820587873459,
-0.02257232554256916,
0.012176889926195145,
0.005664806347340345,
0.021649010479450226,
-0.021746773272752762,
0.0011385283432900906,
0.02219213731586933,
-0.03393452614545822,
0.008271812461316586,
0.005588768981397152,
-0.010047835297882557,
-0.0019715481903403997,
0.02097553387284279,
-0.029763316735625267,
0.013371767476201057,
0.0015696347691118717,
-0.011622901074588299,
-0.021138472482562065,
-0.04056066647171974,
-0.0001239006669493392,
0.004035427700728178,
-0.015913598239421844,
0.002687116852030158,
0.024179978296160698,
-0.00435315677896142,
-0.008592256344854832,
-0.002148064086213708,
0.02624385803937912,
-0.01107434369623661,
-0.0028052469715476036,
-0.004021849483251572,
-0.04783855751156807,
-0.01581583544611931,
0.021453484892845154,
-0.03545527905225754,
-0.020834321156144142,
-0.0003038112190552056,
0.00010293938976246864,
0.014653544872999191,
-0.005860331933945417,
-0.01630464941263199,
0.008304399438202381,
0.0010434812866151333,
-0.0326961986720562,
0.0054611340165138245,
0.025983158499002457,
0.002802531234920025,
-0.010417160578072071,
-0.015750659629702568,
0.031175443902611732,
-0.010020678862929344,
0.020378096029162407,
-0.0009233145392499864,
0.025744182989001274,
0.035064227879047394,
-0.05422572046518326,
0.025135882198810577,
0.00435858778655529,
0.009700234048068523,
-0.002611079253256321,
0.03093646839261055,
-0.015609447844326496,
-0.00803826842457056,
0.018781304359436035,
-0.046448152512311935,
-0.002672180999070406,
-0.02023688331246376,
0.041668642312288284,
-0.030523693189024925,
-0.000919241108931601,
0.008163186721503735,
-0.009287457913160324,
-0.06100393831729889,
-0.009922916069626808,
0.04214659333229065,
-0.008222931064665318,
-0.007169266231358051,
0.0022865612991154194,
0.029785040766000748,
0.004225521814078093,
0.045492250472307205,
-0.0008819011854939163,
0.015109770931303501,
-0.041690368205308914,
-0.007875329814851284,
-0.010178185068070889,
0.004097887314856052,
-0.019878419116139412,
0.03013264201581478,
-0.03754088282585144,
-0.034282125532627106,
0.02620040811598301,
0.0107973488047719,
-0.00402456521987915,
-0.009792565368115902,
-0.0007529087015427649,
0.015587721951305866,
0.02357167750597,
0.04106034338474274,
-0.04140794277191162,
-0.025570381432771683,
-0.04325457289814949,
-0.009200558066368103,
-0.022333350032567978,
-0.00829353742301464,
-0.006235089153051376,
-0.005757137667387724,
-0.0329134501516819,
-0.0058929193764925,
-0.00775584252551198,
0.020932083949446678,
-0.010216204449534416,
0.023202352225780487,
0.03469490259885788,
0.02195316180586815,
-0.03767123445868492,
0.028546713292598724,
0.015565996989607811,
0.00941780861467123,
-0.01368678081780672,
0.0032940604723989964,
-0.019020279869437218,
0.01787971518933773,
-0.027047686278820038,
-0.005518162157386541,
-0.011807563714683056,
0.012296377681195736,
-0.04214659333229065,
0.03454282879829407,
-0.02544003166258335,
0.0018669964047148824,
-0.023745479062199593,
0.005442124791443348,
0.0040164184756577015,
0.010791918262839317,
-0.023962728679180145,
-0.039995815604925156,
0.00775584252551198,
0.027873236685991287,
-0.002970900386571884,
0.015261846594512463,
-0.0035846331156790257,
0.032478947192430496,
0.015707209706306458,
-0.01823817752301693,
0.005806019064038992,
-0.01555513497442007,
0.012991579249501228,
-0.0005760532221756876,
0.015174946747720242,
-0.0011846940033137798,
-0.015674622729420662,
0.03004574216902256,
0.0032614730298519135,
0.0034678608644753695,
0.04770820587873459,
-0.017043299973011017,
-0.017738502472639084,
-0.023050276562571526,
0.032500673085451126,
-0.025809356942772865,
-0.0038996462244540453,
0.027829786762595177,
-0.00035167421447113156,
-0.024788280948996544,
0.018976829946041107,
-0.03875748813152313,
0.013599880039691925,
-0.013958343304693699,
0.0009993521962314844,
-0.009515571407973766,
0.00991748459637165,
-0.027742886915802956,
0.01701071299612522,
-0.020443269982933998,
0.061481889337301254,
-0.006414320785552263,
-0.016934676095843315,
-0.010123872198164463,
-0.011579451151192188,
0.00024576461873948574,
0.010417160578072071,
0.010628979653120041,
-0.0160982608795166,
0.008059993386268616,
-0.0037204145919531584,
-0.02348477765917778,
0.02435377985239029,
0.03673705831170082,
-0.040799640119075775,
0.07582041621208191,
0.0009864530293270946,
0.06630484759807587,
0.042841795831918716,
0.005539887584745884,
0.022767851129174232,
-0.01985669508576393,
-0.001664681825786829,
0.00340268574655056,
0.0448404997587204,
-0.00040089504909701645,
-0.032326873391866684,
0.008521649986505508,
0.021562110632658005,
-0.04145139455795288,
-0.02348477765917778,
-0.02446240559220314,
0.04305904731154442,
0.03552045300602913,
-0.002723777899518609,
0.020475858822464943,
0.02337615191936493,
0.0037692959886044264,
0.0027916687540709972,
0.016826050356030464,
-0.034434203058481216,
0.04679575562477112,
-0.01796661503612995,
-0.017651602625846863,
-0.016239473596215248,
-0.0018819323740899563,
0.0200848076492548,
0.013263141736388206,
0.04421047493815422,
-0.009303752332925797,
-0.01611998677253723,
-0.06356748938560486,
0.02919846586883068,
0.014631819911301136,
-0.021323135122656822,
0.005947232246398926,
0.01268742885440588,
0.0319792702794075,
0.042841795831918716,
0.02911156602203846,
-0.0035113110207021236,
0.016358962282538414,
0.031175443902611732,
0.027808062732219696,
0.040756192058324814,
-0.037171557545661926,
0.01315451692789793,
-0.0290681142359972,
-0.021095022559165955,
-0.018020927906036377,
-0.006050426047295332,
-0.01630464941263199,
0.026135234162211418,
0.02528795599937439,
0.03452110290527344,
0.0005315847811289132,
-0.05374776944518089,
0.025657283142209053,
-0.012459315359592438,
0.00018551155517343432,
-0.049142058938741684,
0.027764612808823586,
0.03569425642490387,
-0.024918630719184875,
0.02826428785920143,
0.022246450185775757,
0.009135383181273937,
-0.03491215407848358,
-0.03100164420902729,
0.06074323505163193,
-0.01128616277128458,
0.03969166427850723,
-0.030349893495440483,
0.001674186554737389,
0.002319148974493146,
-0.021268822252750397,
0.02537485770881176,
-0.03682395815849304,
-0.03386935219168663,
0.017619013786315918,
0.008608550764620304,
-0.022181274369359016,
-0.017597289755940437,
-0.009015895426273346,
-0.027438735589385033,
-0.004545966628938913,
0.023767203092575073,
0.04199451953172684,
0.010943992994725704,
0.008456475101411343,
-0.015718072652816772,
0.0345645509660244,
-0.0006286685820668936,
0.04119069129228592,
0.017336588352918625,
0.027851512655615807,
-0.008494493551552296,
-0.008451043628156185,
0.020541032776236534,
-0.010802780278027058,
0.048229608684778214,
0.02168159931898117,
-0.006332851480692625,
-0.05991768464446068,
-0.023267526179552078,
-0.02337615191936493,
0.03008919209241867,
-0.015164083801209927,
-0.024810004979372025,
-0.02219213731586933,
-0.025939708575606346,
0.014229906722903252,
0.014262494631111622,
0.005216727498918772,
0.05691962689161301,
-0.010281379334628582,
0.014012656174600124,
-0.000767165794968605,
0.01734745129942894,
0.012535353191196918,
0.008695450611412525,
-0.0068488214164972305,
-0.014642682857811451,
-0.03358692675828934,
0.006512083113193512,
0.001274988753721118,
-0.005811450537294149,
-0.03282655030488968,
0.017184512689709663,
0.0155225470662117,
0.027699436992406845,
0.023289252072572708,
-0.008347850292921066,
0.0031664257403463125,
0.0048446860164403915,
-0.024006178602576256,
0.012915541417896748,
-0.0014650829834863544,
0.0030632319394499063,
-0.02197488583624363,
-0.002943744184449315,
-0.010058697313070297,
0.006577258463948965,
-0.019085455685853958,
-0.007158403750509024,
0.025700733065605164,
-0.02915501594543457,
-0.017695052549242973,
0.010020678862929344,
0.0025336837861686945,
-0.06995465606451035,
0.017086749896407127,
-0.011264437809586525,
-0.017695052549242973,
-0.005268324166536331,
-0.030458517372608185,
-0.011525138281285763,
-0.013230554759502411,
0.008847526274621487,
-0.00102718744892627,
0.011677213944494724,
0.04049548879265785,
-0.010759330354630947,
-0.01078648678958416,
-0.012774328701198101,
0.019954457879066467,
-0.061655689030885696,
-0.028503263369202614,
0.060699786990880966,
0.010368279181420803,
-0.052878767251968384,
0.02728666178882122,
0.014251631684601307,
0.006740196142345667,
0.020312920212745667,
-0.005260177422314882,
-0.005376949440687895,
0.036128755658864975,
0.00306866317987442,
0.03093646839261055,
0.02265922538936138,
0.026982510462403297,
0.01696726307272911,
-0.007679804693907499,
-0.032522398978471756,
0.0015424784505739808,
0.013719367794692516,
0.0009280669037252665,
-0.008635707199573517,
0.009488414973020554,
0.027742886915802956,
0.013795405626296997,
-0.017640739679336548,
-0.022213861346244812,
0.025765907019376755,
0.03210962191224098,
0.04158174246549606,
-0.0066152773797512054,
-0.005238452460616827,
0.0001642108109081164,
-0.010335692204535007,
0.01596791110932827,
0.0021562110632658005,
0.0002924395084846765,
-0.007451691664755344,
-0.014707857742905617,
0.014740445651113987,
0.003932233899831772,
-0.016869500279426575,
-0.039908915758132935,
0.05266151949763298,
-0.035281479358673096,
-0.016619661822915077,
0.04866410791873932,
0.023006826639175415,
-0.0018520604353398085,
0.007859036326408386,
0.042754895985126495,
-0.017586426809430122,
-0.012481040321290493,
-0.02917673997581005,
0.04149484261870384,
0.01592446118593216,
-0.0469261035323143,
-0.004228237550705671,
-0.005811450537294149,
-0.028307737782597542,
0.013067617081105709,
-0.02257232554256916,
0.007152972277253866,
-0.01917235553264618,
0.009037620387971401,
-0.04249419644474983,
-0.00018805745639838278,
0.007109522353857756,
-0.005691962782293558,
0.028481539338827133,
0.007663510739803314,
-0.007375653833150864,
0.048229608684778214,
-0.0017434351611882448,
-0.006354576908051968,
0.004410184919834137,
0.009895759634673595,
-0.006501220632344484,
-0.012980716302990913,
-0.039735112339258194,
-0.003837186610326171,
0.01262225303798914,
0.02444067969918251,
-0.0016836912836879492,
-0.0069465842097997665,
0.014631819911301136,
-0.00818491168320179,
-0.005146120674908161,
-0.013795405626296997,
-0.0031664257403463125,
-0.016869500279426575,
-0.024614479392766953,
0.032522398978471756,
-0.018607504665851593,
-0.017542976886034012,
0.05335671827197075,
-0.007131247315555811,
0.029285365715622902,
0.03165339678525925,
0.02344132773578167,
0.038084011524915695,
-0.022181274369359016,
0.012752603739500046,
0.015935322269797325,
-0.004287981428205967,
-0.040712740272283554,
0.01874871738255024,
-0.029763316735625267,
0.008467338047921658,
-0.027438735589385033,
-0.011753251776099205,
-0.01509890891611576,
-0.022854750975966454,
0.00456497585400939,
-0.015229258686304092,
0.02219213731586933,
0.012079127132892609,
-0.0200848076492548,
0.010140166617929935,
-0.01656534895300865,
0.0023490209132432938,
-0.0026151526253670454,
0.010313967242836952,
0.023897552862763405,
-0.0013259068364277482,
-0.00803826842457056,
-0.010514923371374607,
-0.03019781783223152,
0.005010339431464672,
0.011633763089776039,
0.00896158255636692,
-0.0006283291149884462,
0.020823458209633827,
0.0172822754830122,
0.0028867158107459545,
0.028459813445806503,
0.03441247716546059,
0.012752603739500046,
-0.0403868667781353,
-0.005930938292294741,
0.013762818649411201,
-0.0026287308428436518,
0.02919846586883068,
0.02620040811598301,
0.010091285221278667,
-0.004676316864788532,
0.009743683971464634,
-0.010482336394488811,
0.011633763089776039,
-0.033456575125455856,
-0.017423488199710846,
0.003579201875254512,
0.020584482699632645,
-0.05235736817121506,
-0.028742238879203796,
-0.001902299583889544,
-0.004803951364010572,
0.016608798876404762,
0.013382630422711372,
-0.024918630719184875,
0.02728666178882122,
-0.016782600432634354,
-0.01685863733291626,
-0.0011704369680956006,
0.027547361329197884,
0.01273087877780199,
-0.013589018024504185,
0.014925108291208744,
0.011144950054585934,
0.040691014379262924,
0.016695700585842133,
0.00835328083485365,
-0.007690667174756527,
-0.013697642832994461,
0.014262494631111622,
-0.009021326899528503,
-0.005567043554037809,
0.010971149429678917,
-0.001628020778298378,
0.0056322189047932625,
0.0024820868857204914,
0.04979380965232849,
-0.01892251707613468,
0.011394787579774857,
0.016804324463009834,
-0.023854102939367294,
-0.0028296876698732376,
0.005254745949059725,
0.030219541862607002,
0.007891624234616756,
0.017380038276314735,
0.01170980092138052,
-0.015783248469233513,
0.012176889926195145,
-0.005167846102267504,
0.010628979653120041,
0.007527729496359825,
-0.014838208444416523,
-0.013697642832994461,
-0.06652209907770157,
-0.0487944595515728,
-0.008011111989617348,
-0.0046980418264865875,
-0.006696746218949556,
0.0027373561169952154,
-0.0015316159697249532,
0.009749115444719791,
0.029263639822602272,
-0.0019593278411775827,
-0.05457332357764244,
0.051184214651584625,
0.00820663757622242,
-0.007288753986358643,
-0.01970461942255497,
0.027460461482405663,
0.040777917951345444,
-0.041712094098329544,
-0.018672678619623184,
-0.020226020365953445,
-0.012035677209496498,
0.020291196182370186,
-0.016956400126218796,
0.01656534895300865,
0.01879216730594635,
0.021160196512937546,
0.005376949440687895,
-0.0018520604353398085,
-0.005032064393162727,
0.03788848593831062,
-0.01787971518933773,
-0.012459315359592438,
0.005539887584745884,
-0.003177288454025984,
-0.026634909212589264,
0.004391175229102373,
0.04003926366567612,
0.014316807501018047,
0.00803826842457056,
0.0039186556823551655,
0.029307089745998383,
-0.020888634026050568,
-0.01654362492263317,
0.010368279181420803,
0.016912950202822685,
0.01449060719460249,
-0.005360655952244997,
-0.027829786762595177,
-0.04114724323153496,
0.009912053123116493,
0.03260929882526398,
-0.0007277891272678971,
-0.003408116986975074,
0.045622602105140686,
0.002794384490698576,
-0.036107029765844345,
0.0012485113693401217,
0.0016144426772370934,
0.03217479586601257,
0.027742886915802956,
-0.019824106246232986,
-0.02197488583624363,
-0.018987692892551422,
0.03258757293224335,
-0.013469530269503593,
-0.04631780460476875,
0.0012023457093164325,
-0.007033484522253275,
-0.006495789624750614,
0.007739548571407795,
-0.021583836525678635,
-0.009059345349669456,
0.03213134780526161,
-0.0005444840062409639,
0.023680303245782852,
0.045492250472307205,
-0.010265085846185684,
0.007250735070556402,
-0.02068224549293518,
-0.000463354546809569,
0.0016022223280742764,
-0.010634411126375198,
-0.019519956782460213,
-0.0024943072348833084,
-0.06869460642337799,
-0.01588101126253605,
0.01794489100575447,
-0.019389605149626732,
-0.0077341170981526375,
-0.006990034598857164,
0.00015776119835209101,
0.021138472482562065,
-0.02446240559220314,
-0.013382630422711372,
0.022746125236153603,
-0.022181274369359016,
0.01881389133632183,
-0.0126113910228014,
0.03002401813864708,
-0.019802382215857506,
0.013632467947900295,
-0.02431032992899418,
0.0013550999574363232,
0.01828162930905819,
-0.028763964772224426,
0.01685863733291626,
-0.008201206102967262,
0.0336303748190403,
-0.002559482352808118,
0.030349893495440483,
-0.02819911390542984,
0.04053894057869911,
0.015935322269797325,
-0.011405650526285172,
0.014827345497906208,
0.039126813411712646,
-0.05340017005801201,
-0.0005675668944604695,
0.010791918262839317,
0.024636205285787582,
0.0021114032715559006,
0.02620040811598301,
0.026895610615611076,
-0.0032696197740733624,
-0.031566496938467026,
0.010971149429678917,
-0.0023965444415807724,
-0.024983806535601616,
-0.04425392299890518,
-0.013143653981387615,
-0.00013340538134798408,
-0.01683691330254078,
-0.0562678761780262,
0.019042005762457848,
0.01732572540640831,
0.023745479062199593,
-0.01108520571142435,
-0.0031908664386719465,
-0.05796242877840996,
-0.004336862824857235,
-0.04112551733851433,
-0.03278309851884842,
0.010971149429678917,
-0.02524450607597828,
-0.004412900656461716,
0.019911007955670357,
0.01819472759962082,
0.012220339849591255,
0.0121986148878932,
0.015598584897816181,
-0.012220339849591255,
-0.009928347542881966,
-0.004885420203208923,
-0.007283322513103485,
0.011264437809586525,
-0.02437550388276577,
-0.008690019138157368,
0.008304399438202381,
0.0075548854656517506,
-0.012024814262986183,
0.024875180795788765,
0.04345009848475456,
0.0067130401730537415,
0.031370971351861954,
-0.006984603125602007,
0.023158902302384377,
-0.017619013786315918,
-0.005222158506512642,
0.08507528901100159,
-0.04575295373797417,
0.010721311904489994,
0.023310977965593338,
-0.007571179419755936,
-0.019443918019533157,
0.020942946895956993,
-0.013252279721200466,
-0.002851412631571293,
0.005844037979841232,
0.011177537962794304,
0.015153221786022186,
0.034086599946022034,
0.018205590546131134,
0.025092430412769318,
-0.010210772976279259,
-0.025700733065605164,
0.05635477602481842,
-0.00826094951480627,
-0.010943992994725704,
0.037019483745098114,
0.017271414399147034,
0.018086103722453117,
0.032261695712804794,
-0.021442623808979988,
0.005173277109861374,
-0.006577258463948965,
-0.02219213731586933,
0.019650306552648544,
-0.0037910209503024817,
-0.007353928871452808,
0.022333350032567978,
0.013404355384409428,
-0.01551168505102396,
0.01461009494960308,
-0.020367233082652092,
-0.0052819023840129375,
0.0014311375562101603,
-0.016185160726308823,
0.0030713786836713552,
0.024592755362391472,
0.012046539224684238,
-0.0054529872722923756,
-0.010145598091185093,
0.008326125331223011,
0.03771468624472618,
-0.04014788940548897,
0.030501969158649445,
0.018998555839061737,
-0.02900294028222561,
0.02528795599937439,
0.010319397784769535,
0.033456575125455856,
-0.008711744099855423,
-0.02806876227259636,
-0.03163167089223862,
-0.0015546987997367978,
-0.009140814654529095,
0.005594199988991022,
-0.013176241889595985,
0.001503101782873273,
0.023093726485967636,
0.004516094457358122,
-0.019976181909441948,
-0.005871194414794445
] | 2025-01-12 | 1 | 39798090 | [
"immune cells",
"modulates immune cell function",
"immune cell functionality",
"antitumor immune responses",
"cancer immunotherapy",
"cancer metabolism",
"CAR)-T cells",
"cancer",
"Metabolic",
"chimeric antigen receptor",
"nutrient competition",
"existing treatment protocols",
"the antitumor immune response",
"therapeutic strategies",
"innovative combinations",
"effector functions",
"both immune and cancer cells",
"Metabolic crosstalk",
"Recent studies",
"acidosis",
"survival",
"carcinogenesis",
"the tumor microenvironment results",
"differentiation",
"immunotherapy, cellular therapies, and metabolic interventions",
"these metabolic pathways",
"a crucial role",
"the efficacy",
"their proliferation",
"the regulation"
] | [
"CP: Cancer",
"CP: Metabolism",
"antitumor activity of immune cells",
"cancer",
"metabolism",
"therapeutic strategies",
"tumor microenvironment"
] | 0 | 10.1016/j.celrep.2024.115206 | [
"Ricci"
] | [
"Université Côte d'Azur, INSERM, C3M, Nice, France; Équipe labellisée LIGUE Contre le Cancer, Nice, France. Electronic address: [email protected]."
] | [
"39798090"
] | [] | 10.449526 | 4.880123 |
39796666 | 43 | Engineered Cellular Therapies for the Treatment of Thoracic Cancers. | Thoracic malignancies (lung cancers and malignant pleural mesothelioma) are prevalent worldwide and are associated with high morbidity and mortality. Effective treatments are needed for patients with advanced disease. Cell therapies are a promising approach to the treatment of advanced cancers that make use of immune effector cells that have the ability to mediate antitumor immune responses. In this review, we discuss the prospect of chimeric antigen receptor-T (CAR-T) cells, natural killer (NK) cells, T cell receptor-engineered (TCR-T) cells, and tumor-infiltrating lymphocytes (TILs) as treatments for thoracic malignancies. CAR-T cells and TILs have proven successful in several hematologic cancers and advanced melanoma, respectively, but outside of melanoma, results have thus far been unsuccessful in most other solid tumors. NK cells and TCR-T cells are additional cell therapy platforms with their own unique advantages and challenges. Obstacles that must be overcome to develop effective cell therapy for these malignancies include selecting an appropriate target antigen, combating immunosuppressive cells and signaling molecules present in the tumor microenvironment, persistence, and delivering a sufficient quantity of antitumor immune cells to the tumor. Induced pluripotent stem cells (iPSCs) offer great promise as a source for both NK and T cell-based therapies due to their unlimited expansion potential. Here, we review clinical trial data, as well as recent basic scientific advances that offer insight into how we may overcome these obstacles, and provide an overview of ongoing trials testing novel strategies to overcome these obstacles. | [
0.0007365582860074937,
0.025262849405407906,
0.06376176327466965,
0.05237259343266487,
-0.002189062302932143,
-0.02825305610895157,
-0.004938788246363401,
0.03221068158745766,
0.006546574179083109,
0.013356990180909634,
-0.00806916132569313,
-0.02827504277229309,
-0.027505503967404366,
0.03555268049240112,
0.011620031669735909,
-0.021283237263560295,
0.056374192237854004,
-0.01551169715821743,
0.03634420409798622,
0.03306816890835762,
0.017897266894578934,
0.02101939544081688,
0.0012175198644399643,
-0.022206682711839676,
-0.04705178365111351,
0.012378576211631298,
0.010751551948487759,
0.018864687532186508,
-0.025064967572689056,
-0.029308423399925232,
0.027021795511245728,
-0.023723773658275604,
-0.023811720311641693,
-0.01050969772040844,
-0.003333750646561384,
0.016204282641410828,
0.03104538284242153,
0.033222075551748276,
-0.01971117965877056,
-0.004468820057809353,
0.045248862355947495,
-0.008778235875070095,
0.00163252092897892,
0.08741957694292068,
-0.05932042375206947,
0.0022028039675205946,
0.0015761797549203038,
-0.06116731837391853,
-0.0018963627517223358,
-0.01377473957836628,
-0.002105237450450659,
-0.011290228925645351,
-0.010245855897665024,
0.03962023928761482,
-0.053955644369125366,
0.040257856249809265,
-0.06248652562499046,
-0.0047409068793058395,
-0.0037817321717739105,
0.013466923497617245,
-0.005323557648807764,
-0.0031248759478330612,
0.02856087125837803,
-0.01845793053507805,
-0.04691986367106438,
-0.0013432569103315473,
-0.02348191849887371,
-0.03478313982486725,
-0.00335573754273355,
0.03328803554177284,
0.004576005972921848,
-0.008899163454771042,
-0.008019690401852131,
0.012620431371033192,
0.012587451376020908,
-0.000794273684732616,
0.013324009254574776,
0.03878474235534668,
0.012488510459661484,
-0.0027208682149648666,
0.04881072789430618,
-0.007431543432176113,
0.013049174100160599,
-0.022426551207900047,
-0.012345596216619015,
0.022371584549546242,
-0.0022344100289046764,
0.004540277179330587,
-0.0618269219994545,
-0.014885073527693748,
-0.03163902461528778,
0.013148115016520023,
-0.03020988218486309,
0.026516098529100418,
-0.01127923559397459,
0.01373076532036066,
-0.004446833394467831,
-0.05285630375146866,
0.02345993183553219,
0.03643215075135231,
0.03764142468571663,
0.023020194843411446,
-0.029308423399925232,
-0.0006609786069020629,
0.044457338750362396,
-0.012928246520459652,
-0.04390766844153404,
-0.011850892566144466,
0.038608845323324203,
0.02765941247344017,
0.04472117871046066,
0.01147711742669344,
0.002205552300438285,
0.026274243369698524,
-0.03819109499454498,
-0.0544833280146122,
-0.023723773658275604,
-0.012114734388887882,
0.029880080372095108,
0.06644415110349655,
-0.008080154657363892,
0.03502499684691429,
0.025174902752041817,
0.009080554358661175,
-0.005985910072922707,
-0.04021388292312622,
0.07844895124435425,
-0.023613838478922844,
-0.023437943309545517,
-0.035926453769207,
0.028209082782268524,
0.012169701978564262,
0.02867080643773079,
-0.00995452981442213,
-0.07457927614450455,
0.008690288290381432,
-0.011971820145845413,
0.01408255472779274,
0.02040376327931881,
-0.023921653628349304,
-0.0021808170713484287,
-0.016600044444203377,
-0.0027442292775958776,
-0.004479813389480114,
-0.03610235080122948,
-0.0514051727950573,
0.015588651411235332,
0.02695583365857601,
-0.004350640811026096,
0.029880080372095108,
-0.06560865789651871,
0.04661204665899277,
0.061695002019405365,
0.024273443967103958,
-0.035046983510255814,
-0.025944441556930542,
-0.006925846450030804,
0.08007597923278809,
-0.03654208406805992,
-0.09058567881584167,
-0.011108838021755219,
0.019513297826051712,
-0.019722172990441322,
-0.013675798662006855,
0.011982813477516174,
-0.0055269356817007065,
-0.0030286835972219706,
0.027087755501270294,
-0.03328803554177284,
-0.009828106500208378,
-0.03350790590047836,
-0.05962824076414108,
-0.064509317278862,
-0.008184591308236122,
-0.032826315611600876,
-0.017523491755127907,
0.053735774010419846,
0.040675606578588486,
-0.04263243451714516,
-0.00474915187805891,
-0.01458825170993805,
0.045556679368019104,
0.018842700868844986,
0.01469818502664566,
-0.02682391367852688,
0.03808116167783737,
-0.01230162288993597,
0.03867480531334877,
-0.04520488902926445,
-0.004812364000827074,
-0.0008203830220736563,
-0.005864982958883047,
0.02070058509707451,
0.027681399136781693,
-0.010058967396616936,
0.027065768837928772,
0.023723773658275604,
0.026999808847904205,
-0.008992606773972511,
-0.03256247192621231,
0.0514051727950573,
-0.020337803289294243,
-0.04502899572253227,
-0.011042877100408077,
0.0008506148587912321,
-0.03212273493409157,
-0.01694084145128727,
0.06420149654150009,
0.011674998328089714,
0.008811215870082378,
0.0357285737991333,
0.004207726567983627,
0.01613832265138626,
0.02838497795164585,
-0.03988408297300339,
-0.014555270783603191,
-0.015137922018766403,
0.020799526944756508,
0.029528291895985603,
0.0291765034198761,
0.028912661597132683,
0.0010526187252253294,
-0.01525884959846735,
0.019304422661662102,
-0.026296230033040047,
-0.009426847100257874,
0.019139522686600685,
-0.013345995917916298,
0.009217971935868263,
-0.025086956098675728,
-0.021283237263560295,
-0.011345196515321732,
0.013258049264550209,
-0.012642418034374714,
-0.029330410063266754,
-0.04511694237589836,
0.004658456426113844,
-0.008706778287887573,
0.04419349879026413,
-0.010256849229335785,
0.022283636033535004,
0.019986014813184738,
0.01990905962884426,
-0.02183290757238865,
-0.02337198331952095,
-0.011004400439560413,
-0.006282732356339693,
-0.06842296570539474,
0.006804918870329857,
-0.011806919239461422,
-0.008602340705692768,
0.0185568705201149,
0.007777835708111525,
0.0025779539719223976,
0.02328403666615486,
0.007953730411827564,
0.04102739691734314,
-0.02317410334944725,
0.002472142456099391,
-0.006106837652623653,
-0.005881472956389189,
0.017226669937372208,
-0.03836699202656746,
-0.04223667085170746,
-0.07018191367387772,
-0.014181495644152164,
-0.03031981736421585,
0.010960427112877369,
0.06406957656145096,
-0.021766945719718933,
0.025086956098675728,
0.009113534353673458,
0.0479312539100647,
-0.04560065269470215,
-0.05738558620214462,
-0.021173302084207535,
0.008047173731029034,
0.01443434413522482,
0.007129224482923746,
0.021074362099170685,
-0.008607838302850723,
0.005131172947585583,
0.0023938145022839308,
-0.042808327823877335,
-0.006607037968933582,
-0.013598844408988953,
0.011685991659760475,
0.0028610341250896454,
-0.022305622696876526,
-0.05144914612174034,
0.01978813298046589,
-0.0030094452667981386,
-0.03735559806227684,
-0.01959025114774704,
-0.011971820145845413,
0.02326205000281334,
-0.0050734574906528,
-0.029550278559327126,
-0.02499900758266449,
0.02695583365857601,
-0.034849099814891815,
-0.000844431109726429,
-0.00852538738399744,
-0.05052569881081581,
0.020447736606001854,
0.005133921280503273,
-0.024977020919322968,
-0.003872427623718977,
0.025944441556930542,
0.042412564158439636,
0.030429750680923462,
-0.017017794772982597,
0.022690393030643463,
0.022932248190045357,
0.006804918870329857,
0.008591347374022007,
0.04436939209699631,
-0.04885470122098923,
0.003751500276848674,
-0.03836699202656746,
-0.048722781240940094,
-0.0032925254199653864,
-0.029880080372095108,
0.018337003886699677,
0.024471323937177658,
-0.03715771809220314,
0.030781541019678116,
-0.010328305885195732,
0.030847501009702682,
-0.05232862010598183,
-0.018743759021162987,
-0.031089356169104576,
0.0699620470404625,
-0.027835307642817497,
0.013521891087293625,
-0.012664404697716236,
-0.01968919299542904,
-0.05457127466797829,
0.014423349872231483,
0.012554471381008625,
0.0006252500461414456,
0.01805117540061474,
-0.03643215075135231,
0.07361185550689697,
0.00979512557387352,
-0.030077962204813957,
-0.0032952737528830767,
0.026801927015185356,
0.005274087190628052,
0.036783941090106964,
-0.00770637858659029,
0.037509504705667496,
0.01229062955826521,
-0.006128824315965176,
-0.028341004624962807,
0.030781541019678116,
-0.026977822184562683,
-0.022371584549546242,
0.02634020335972309,
0.0012470646761357784,
-0.005315312184393406,
-0.018732765689492226,
-0.04410554841160774,
0.04032381623983383,
0.0579572431743145,
0.07994405925273895,
-0.02326205000281334,
0.04256647452712059,
-0.04368780180811882,
-0.03966421261429787,
-0.007360086310654879,
0.004397362936288118,
0.055582668632268906,
-0.002381446771323681,
-0.02326205000281334,
0.037927255034446716,
-0.008393466472625732,
0.000328771595377475,
0.03170498460531235,
0.034233469516038895,
0.03968619927763939,
-0.016149315983057022,
0.000861608306877315,
-0.015192888677120209,
-0.038630831986665726,
0.017985213547945023,
0.026208283379673958,
-0.04502899572253227,
-0.06437738984823227,
0.03377174586057663,
0.023811720311641693,
-0.009542277082800865,
0.009322409518063068,
-0.0018482665764167905,
-0.035882480442523956,
0.05734161287546158,
-0.05668200924992561,
0.08284631371498108,
0.03641016408801079,
-0.010570161044597626,
0.003410704666748643,
-0.02897862158715725,
-0.015280836261808872,
-0.037311624735593796,
0.010652611963450909,
-0.049646228551864624,
0.023196090012788773,
0.014379376545548439,
0.02477913908660412,
-0.03722367808222771,
-0.01897462084889412,
0.007535980548709631,
0.03201280161738396,
0.02449331060051918,
-0.003894414519891143,
-0.03579453378915787,
-0.0020901216194033623,
0.03755347803235054,
-0.0031166309490799904,
0.004188488237559795,
0.008338499814271927,
-0.04955827817320824,
0.027219675481319427,
-0.043006207793951035,
0.011521090753376484,
-0.012686392292380333,
0.041071370244026184,
-0.017919253557920456,
-0.0029160012491047382,
-0.05144914612174034,
-0.0405876599252224,
0.0664881244301796,
-0.0019417105941101909,
-0.017072761431336403,
-0.02603238821029663,
0.0434679314494133,
-0.036476124078035355,
-0.004331402480602264,
-0.024273443967103958,
0.030737565830349922,
-0.025878479704260826,
-0.03537678346037865,
0.029572265222668648,
-0.030033988878130913,
0.024933047592639923,
0.017809320241212845,
0.017193688079714775,
0.03339797258377075,
-0.03276035189628601,
-0.02072257176041603,
0.02328403666615486,
-0.015313816256821156,
0.017226669937372208,
0.012015794403851032,
-0.014181495644152164,
-0.03856487199664116,
0.017677398398518562,
-0.06873077899217606,
-0.00607385765761137,
0.005103689152747393,
0.030737565830349922,
-0.04071957990527153,
0.012004801072180271,
-0.04491906240582466,
-0.014995007775723934,
0.03834500536322594,
0.06314612925052643,
-0.014489310793578625,
0.02634020335972309,
-0.03951030597090721,
0.03410154953598976,
-0.0392024889588356,
-0.028846699744462967,
-0.02774735912680626,
-0.0002066417073365301,
0.05254848673939705,
0.026801927015185356,
0.004339647479355335,
-0.005532432347536087,
0.01702878810465336,
0.00013071848661638796,
0.009168501943349838,
-0.05263643339276314,
-0.015962427482008934,
0.02195383422076702,
-0.012939239852130413,
-0.05707776919007301,
0.0008849692530930042,
-0.011114334687590599,
0.05417551100254059,
-0.031287238001823425,
-0.0073326025158166885,
0.028033187612891197,
-0.0077668423764407635,
-0.001114456681534648,
-0.01899660751223564,
-0.008492407388985157,
-0.010982413776218891,
-0.04135719686746597,
0.008717771619558334,
-0.006304719019681215,
0.004691436421126127,
-0.007360086310654879,
0.01805117540061474,
0.04089547321200371,
0.01725964993238449,
0.033112142235040665,
0.05668200924992561,
-0.004235210362821817,
0.01795223355293274,
-0.050569672137498856,
0.006007897201925516,
0.04379773512482643,
-0.012851293198764324,
-0.020381776615977287,
-0.018227068707346916,
-0.05518690496683121,
0.001037502777762711,
-0.028406964614987373,
-0.0064201499335467815,
-0.005543425679206848,
-0.0025339804124087095,
-0.03256247192621231,
-0.008800222538411617,
0.02378973364830017,
-0.01876574568450451,
-0.04731562361121178,
-0.00538127264007926,
-0.012114734388887882,
-0.0390046089887619,
-0.0016421402106061578,
-0.0210413821041584,
0.01592944748699665,
0.023020194843411446,
-0.021261248737573624,
0.0001539077056804672,
-0.03298022225499153,
0.005422498099505901,
-0.03443135321140289,
-0.03482711315155029,
0.021250255405902863,
-0.0077008819207549095,
0.012268642894923687,
0.0006462062010541558,
0.002924246247857809,
0.006738958414644003,
-0.0013460052432492375,
-0.01244453713297844,
-0.0038751759566366673,
-0.008387969806790352,
0.030143922194838524,
-0.04929443821310997,
0.021788932383060455,
-0.007579954341053963,
0.02499900758266449,
-0.007585451006889343,
-0.012499503791332245,
-0.023635825142264366,
-0.005219120066612959,
0.022998208180069923,
-0.030165908858180046,
-0.011674998328089714,
0.021975820884108543,
-0.022602444514632225,
0.012928246520459652,
0.010289829224348068,
-0.01520388200879097,
0.00229762215167284,
-0.03561864048242569,
0.049646228551864624,
0.005777035374194384,
-0.009553270414471626,
0.01077353861182928,
-0.020546678453683853,
0.05070159584283829,
-0.016347195953130722,
-0.000046850811486365274,
0.0101469149813056,
-0.015335802920162678,
0.015379776246845722,
-0.04008196294307709,
-0.016083354130387306,
-0.010537181049585342,
0.03896063566207886,
0.00994903314858675,
0.02040376327931881,
-0.04181892052292824,
-0.01601739414036274,
-0.010746055282652378,
-0.004980013240128756,
0.05202080309391022,
0.004955278243869543,
0.02572457306087017,
-0.014170502312481403,
-0.02223966270685196,
0.02581251971423626,
-0.009542277082800865,
-0.03594844043254852,
0.009086051024496555,
-0.0065355803817510605,
-0.01797422021627426,
0.0008726016967557371,
-0.019777139648795128,
-0.040873486548662186,
-0.025966428220272064,
0.027021795511245728,
0.0003251643793191761,
-0.01164201833307743,
0.017270643264055252,
0.008503400720655918,
0.03326604887843132,
0.018435943871736526,
-0.03254048526287079,
-0.0027194940485060215,
0.0459524430334568,
0.0017342099454253912,
0.0038696792908012867,
0.003644314594566822,
0.010905459523200989,
-0.023042181506752968,
-0.040367789566516876,
-0.007508497219532728,
-0.003751500276848674,
-0.0003961062175221741,
-0.01164201833307743,
-0.058221083134412766,
-0.024251455441117287,
0.00538676930591464,
0.023921653628349304,
-0.011872880160808563,
0.013752751983702183,
-0.047095756977796555,
0.013796726241707802,
0.046787939965724945,
-0.021184295415878296,
-0.037707388401031494,
0.041994813829660416,
-0.021173302084207535,
0.015610638074576855,
0.013554871082305908,
-0.011163804680109024,
0.0038999111857265234,
-0.018732765689492226,
-0.018919654190540314,
-0.008305518887937069,
0.014225468970835209,
-0.025174902752041817,
0.006914853118360043,
0.017006801441311836,
-0.010267842561006546,
0.019975021481513977,
0.0033832211047410965,
0.022580457851290703,
-0.025570664554834366,
0.01045473013073206,
0.010735061950981617,
0.003270538756623864,
-0.020777540281414986,
0.044941049069166183,
0.04929443821310997,
-0.01556666474789381,
0.021459130570292473,
-0.011499104090034962,
0.016578057780861855,
-0.0081626046448946,
-0.012466523796319962,
0.01179592590779066,
-0.0020598897244781256,
0.020733565092086792,
-0.012400563806295395,
0.08029584586620331,
0.03467320650815964,
0.02306416817009449,
-0.0010216997470706701,
0.020590651780366898,
0.03564062714576721,
0.0005713136051781476,
-0.0014648714568465948,
-0.015797525644302368,
0.010740558616816998,
0.008179094642400742,
0.02194284088909626,
-0.030143922194838524,
-0.054351404309272766,
-0.0074920072220265865,
-0.0059749167412519455,
0.008327505551278591,
0.021008402109146118,
0.003520638681948185,
0.010537181049585342,
0.028846699744462967,
-0.018644819036126137,
-0.027527492493391037,
-0.017512498423457146,
0.0029517298098653555,
0.026867887005209923,
0.00474640354514122,
-0.03009994886815548,
-0.0014978516846895218,
-0.04766741394996643,
0.014071561396121979,
0.015687592327594757,
0.008695784956216812,
-0.022294629365205765,
0.024933047592639923,
-0.003476665122434497,
-0.010707578621804714,
0.012620431371033192,
0.007167701609432697,
0.010883472859859467,
-0.02816510945558548,
0.006095844320952892,
-0.005098192486912012,
-0.019150516018271446,
-0.01475315261632204,
-0.00898711010813713,
-0.0011886621359735727,
0.015225868672132492,
-0.00852538738399744,
0.008855189196765423,
0.023635825142264366,
0.02317410334944725,
0.012510497123003006,
0.002020038664340973,
0.040653619915246964,
0.05338398367166519,
-0.039334412664175034,
0.043314024806022644,
-0.005307067185640335,
-0.007019290700554848,
-0.012840299867093563,
-0.02908855490386486,
-0.03170498460531235,
-0.03113332949578762,
-0.0197001863270998,
0.012499503791332245,
-0.03654208406805992,
-0.02345993183553219,
-0.0007585451239719987,
0.0005417688516899943,
0.01623726263642311,
-0.05672598257660866,
-0.03788328170776367,
-0.006958826910704374,
0.011312215588986874,
0.026670005172491074,
0.017831306904554367,
0.005084450822323561,
0.005191636737436056,
-0.021393170580267906,
-0.0002909817558247596,
0.006266241893172264,
-0.007728365249931812,
-0.019843099638819695,
0.010960427112877369,
-0.046480126678943634,
0.017589451745152473,
-0.001743829227052629,
-0.026911860331892967,
-0.027065768837928772,
-0.03262843191623688,
-0.006876375991851091,
0.009553270414471626,
-0.019315415993332863,
0.0015212127473205328,
0.017985213547945023,
0.016962828114628792,
0.02794524095952511,
-0.002792325336486101,
0.003919149748980999,
-0.03695983439683914,
-0.024053575471043587,
0.024515297263860703,
-0.04010394960641861,
-0.002880272688344121,
0.01623726263642311,
-0.031067369505763054,
0.003798222169280052,
-0.009756648913025856,
0.004347892478108406,
0.001412652782164514,
-0.0029105045832693577,
0.009668701328337193,
-0.011290228925645351,
0.0015912957023829222,
-0.0034244463313370943,
-0.008866182528436184,
0.005925446283072233,
-0.020029988139867783,
-0.018315017223358154,
-0.0202938299626112,
0.039752159267663956,
-0.02348191849887371,
0.024207482114434242,
-0.026406163349747658,
0.0177653469145298,
0.026999808847904205,
-0.08702380955219269,
-0.026164310052990913,
-0.022217676043510437,
-0.012994207441806793,
-0.011081354692578316,
-0.007431543432176113,
-0.04115931689739227,
0.005474716890603304,
0.005221868399530649,
-0.011081354692578316,
0.017600445076823235,
-0.020436743274331093,
0.029726173728704453,
-0.00368553982116282,
-0.02847292460501194,
-0.0062112752348184586,
-0.016896866261959076,
-0.062002815306186676,
-0.02348191849887371,
0.010828506201505661,
-0.017006801441311836,
-0.004460575059056282,
-0.010691088624298573,
0.06275036931037903,
-0.010212874971330166,
0.003542625578120351,
-0.014885073527693748,
-0.038630831986665726,
-0.05470319464802742,
-0.028406964614987373,
-0.02480112761259079,
0.009322409518063068,
-0.022734366357326508,
0.043314024806022644,
-0.014489310793578625,
-0.03509095683693886,
0.015610638074576855,
-0.018402963876724243,
0.0022454033605754375,
-0.01663302443921566,
-0.023921653628349304,
0.028319016098976135,
0.03410154953598976,
0.015280836261808872,
-0.04421548545360565,
-0.01590746082365513,
-0.020733565092086792,
0.011070361360907555,
0.017006801441311836,
-0.005667101591825485,
0.023833706974983215,
-0.036695994436740875,
-0.022206682711839676,
-0.0018688791897147894,
0.007013794034719467,
-0.01362083200365305,
0.0010539928916841745,
0.03755347803235054,
0.009806118905544281,
0.022492511197924614,
-0.01918349601328373,
0.04582052305340767,
0.03201280161738396,
-0.0034574265591800213,
-0.028297029435634613,
-0.01610534079372883,
-0.010080954059958458,
0.02295423485338688,
-0.026867887005209923,
0.001054679974913597,
-0.008272538892924786,
0.003036928828805685,
-0.037289638072252274,
0.029440345242619514,
-0.012323609553277493,
-0.008640818297863007,
-0.007799822371453047,
-0.005452729761600494,
-0.01030082255601883,
0.022503504529595375,
-0.038520898669958115,
-0.00851439405232668,
-0.008910156786441803,
-0.0023993111681193113,
-0.006013393867760897,
-0.017160708084702492,
-0.005021238699555397,
0.00806916132569313,
0.014643218368291855,
-0.0030863990541547537,
0.018106142058968544,
-0.025064967572689056,
-0.009058567695319653,
0.002663152990862727,
-0.004367130808532238,
-0.006596044171601534,
-0.030583659186959267,
-0.009828106500208378,
-0.004779384005814791,
-0.006315712351351976,
0.04705178365111351,
-0.007689888123422861,
-0.016907859593629837,
-0.0009474942926317453,
-0.018721772357821465,
-0.003509645350277424,
0.017677398398518562,
0.01685289293527603,
0.0019472072599455714,
-0.023393969982862473,
0.03962023928761482,
-0.026582058519124985,
0.024273443967103958,
-0.019876079633831978,
-0.017292629927396774,
-0.007876776158809662,
0.038125135004520416,
0.004529283847659826,
0.001677868771366775,
-0.001489606685936451,
0.07378774881362915,
0.02928643673658371,
-0.04274236783385277,
-0.0210413821041584,
0.00008897788939066231,
-0.013466923497617245,
0.0004730600630864501,
-0.0010478091426193714,
-0.0030396771617233753,
0.00619478477165103,
0.01644613780081272,
-0.013291029259562492,
0.043116144835948944,
-0.010806519538164139,
0.01061963103711605,
0.03737758472561836,
-0.00034869712544605136,
0.03122127614915371,
0.0108175128698349,
0.012059767730534077,
-0.006716971751302481,
-0.0006001713336445391,
-0.013818712905049324,
-0.0023457182105630636,
0.054439350962638855,
-0.03768540173768997,
-0.04511694237589836,
-0.0009962775511667132,
0.017479516565799713,
-0.0036937848199158907,
0.019744159653782845,
0.019018594175577164,
0.03559665381908417,
0.06050771474838257,
0.002406182000413537,
0.028494911268353462,
0.03379373252391815,
0.025152916088700294,
-0.038235072046518326,
0.008849692530930042,
-0.0307155791670084,
0.03825705870985985,
-0.03093544766306877,
-0.04344594478607178,
-0.02869279310107231,
-0.020634625107049942,
-0.012928246520459652,
-0.012125727720558643,
0.039532292634248734,
0.02825305610895157,
-0.01164201833307743,
-0.05070159584283829,
0.04309415444731712,
-0.019832106307148933,
-0.02234959602355957,
0.014797125943005085,
0.030275844037532806,
0.0074920072220265865,
0.01373076532036066,
0.029352396726608276,
-0.0219318475574255,
0.010575657710433006,
0.028824713081121445,
0.03216670826077461,
0.029352396726608276,
-0.04276435449719429,
-0.009888569824397564,
-0.00836598314344883,
0.001296535017900169,
0.008745255880057812,
0.008756249211728573,
-0.03528883680701256,
0.008943136781454086,
0.036366190761327744,
0.026516098529100418,
-0.02757146582007408,
-0.01867779903113842,
0.011620031669735909,
-0.007986710406839848,
-0.0029269945807754993,
-0.021569065749645233,
0.016479117795825005,
0.055582668632268906,
-0.01280731987208128,
-0.04947033151984215,
0.023306023329496384,
-0.003410704666748643,
-0.03550870716571808,
-0.0274395439773798,
0.035970427095890045,
0.001852389075793326,
0.062398578971624374,
-0.021272242069244385,
0.022932248190045357,
0.01387367956340313,
-0.003960374742746353,
-0.0025999408680945635,
0.0058320024982094765,
-0.04080752655863762,
-0.0029544781427830458,
-0.04749152064323425,
-0.019667206332087517,
-0.012532483786344528,
-0.007739358581602573,
-0.007513993885368109,
0.026274243369698524,
0.07365582883358002,
0.02856087125837803,
0.007783332373946905,
-0.006321209017187357,
-0.02642815187573433,
0.031089356169104576,
0.013005200773477554,
0.02244853787124157,
0.011707978323101997,
0.024009602144360542,
-0.019227469339966774,
-0.017534485086798668,
0.022283636033535004,
-0.020051974803209305,
0.07888869196176529,
0.03122127614915371,
0.002738732611760497,
-0.045556679368019104,
-0.012895266525447369,
0.02367979846894741,
0.05918850377202034,
-0.02796722762286663,
-0.017061768099665642,
-0.002902259584516287,
-0.016962828114628792,
0.0163252092897892,
0.02243754453957081,
0.021052375435829163,
0.03878474235534668,
0.022283636033535004,
0.007695385254919529,
-0.011004400439560413,
0.02328403666615486,
-0.004655708093196154,
-0.0008293151622638106,
-0.02449331060051918,
-0.01408255472779274,
0.004161004442721605,
0.019942041486501694,
-0.001489606685936451,
-0.0025106193497776985,
-0.030055975541472435,
0.018007200211286545,
0.016369182616472244,
-0.019546277821063995,
0.004334150813519955,
-0.01685289293527603,
-0.014401363208889961,
0.00032756917062215507,
-0.03500301018357277,
0.010471220128238201,
-0.0064696199260652065,
-0.004100541118532419,
-0.022129729390144348,
-0.006359686143696308,
-0.0071951849386096,
-0.007964723743498325,
0.0146871916949749,
0.01276334561407566,
0.0008842821698635817,
-0.026604045182466507,
-0.029858093708753586,
0.00866830162703991,
-0.01754547841846943,
-0.025900468230247498,
-0.007233662065118551,
-0.02317410334944725,
-0.010421750135719776,
-0.013686791993677616,
-0.02162403240799904,
-0.013313015922904015,
0.0003950755635742098,
-0.021459130570292473,
-0.010493206791579723,
0.003707526484504342,
0.02990206703543663,
-0.032408565282821655,
0.003133120946586132,
0.01031181588768959,
-0.009514793753623962,
-0.02151409722864628,
-0.02396562695503235,
0.0357285737991333,
0.004466071724891663,
-0.06402560323476791,
0.03221068158745766,
0.024339403957128525,
-0.016204282641410828,
0.0038559376262128353,
0.0033419958781450987,
-0.0028995112515985966,
0.005441736429929733,
0.030781541019678116,
0.006991806905716658,
-0.005463723558932543,
-0.005034980364143848,
0.005117431282997131,
-0.010630624368786812,
-0.028802726417779922,
0.014181495644152164,
0.018205082044005394,
-0.016358189284801483,
-0.007442536763846874,
-0.01917250268161297,
0.0219318475574255,
-0.0005287141539156437,
0.027989214286208153,
-0.010245855897665024,
0.013510897755622864,
-0.0030754057224839926,
0.004040077328681946,
0.0026755204889923334,
0.0016297725960612297,
0.007024787366390228,
-0.02151409722864628,
0.0059089562855660915,
0.01887568086385727,
-0.00018980805180035532,
-0.009069561026990414,
0.011053871363401413,
-0.013675798662006855,
0.00009593465802026913,
-0.01756746508181095,
-0.011037380434572697,
0.0471397303044796,
-0.006172798108309507,
-0.06094744801521301,
0.04735959693789482,
0.036783941090106964,
0.008025187067687511,
-0.0006118518067523837,
-0.0014009723672643304,
-0.014214475639164448,
0.009322409518063068,
-0.01939237117767334,
0.028934648260474205,
0.03326604887843132,
-0.028428951278328896,
-0.010729565285146236,
0.0176664050668478,
-0.017281636595726013,
-0.01613832265138626,
-0.0004785567580256611,
-0.008910156786441803,
0.011048374697566032,
0.02519688941538334,
-0.015324809588491917,
0.0018372731283307076,
0.010124928317964077,
0.015324809588491917,
0.0215360838919878,
0.03706976771354675,
-0.017215676605701447,
0.036080364137887955,
-0.004771138541400433,
-0.01111983135342598,
-0.0013274538796395063,
-0.0026782688219100237,
-0.001436013844795525,
-0.01950230449438095,
-0.028912661597132683,
-0.015896467491984367,
0.01928243599832058,
0.027637425810098648,
0.006035380531102419,
-0.008838699199259281,
0.021975820884108543,
0.0076349214650690556,
-0.032826315611600876,
0.009883073158562183,
-0.015742558985948563,
0.013950633816421032,
-0.012983214110136032,
0.020139921456575394,
-0.03478313982486725,
-0.011185792274773121,
0.013367983512580395,
-0.007261145394295454,
-0.0005129111814312637,
0.026142321527004242,
0.012081754393875599,
0.05307617038488388,
-0.002979213371872902,
0.002738732611760497,
-0.019568264484405518,
0.006925846450030804,
-0.06310215592384338,
0.013961627148091793,
-0.006683991756290197,
0.014302423223853111,
0.01714971475303173,
-0.011543077416718006,
-0.018721772357821465,
-0.0023457182105630636,
-0.008816712535917759,
-0.01684189960360527,
-0.013983613811433315,
0.005620379466563463,
-0.035574667155742645,
0.0036250760313123465,
0.012059767730534077,
0.00607385765761137,
0.0004424846265465021,
-0.0021450885105878115,
0.008080154657363892,
0.0014318913454189897,
-0.010685591958463192,
0.0036140826996415854,
-0.0312652513384819,
-0.012202681973576546,
-0.015478717163205147,
-0.010696585290133953,
-0.013444936834275723,
0.016182295978069305,
0.0027964480686932802,
0.004427594598382711,
0.04626025632023811,
-0.006244255229830742,
0.01795223355293274,
-0.03306816890835762,
-0.02345993183553219,
0.013708778657019138,
0.009619231335818768,
0.02101939544081688,
0.001328140962868929,
0.03144114464521408,
-0.017072761431336403,
0.01705077476799488,
-0.01126824226230383,
0.012862286530435085,
-0.028450937941670418,
-0.006255248561501503,
0.00009456047700950876,
0.017996206879615784,
-0.036190297454595566,
-0.02264641970396042,
0.005837499164044857,
-0.011246255598962307,
0.02019488997757435,
0.015654612332582474,
-0.016281235963106155,
0.002215171465650201,
-0.01663302443921566,
0.011905860155820847,
-0.003188088070601225,
0.005661604925990105,
0.019458331167697906,
-0.003031431930139661,
-0.0019485814264044166,
-0.035970427095890045,
0.03581652045249939,
0.02623027004301548,
0.012884273193776608,
-0.04430343210697174,
-0.03724566474556923,
0.03020988218486309,
-0.00538676930591464,
0.01928243599832058,
0.002032406162470579,
0.024933047592639923,
-0.007843796163797379,
-0.01613832265138626,
0.046392180025577545,
-0.007513993885368109,
-0.006936839781701565,
0.01096592377871275,
-0.007338099181652069,
-0.006304719019681215,
-0.0229762215167284,
-0.003861434292048216,
-0.008552870713174343,
-0.02460324577987194,
0.0030424254946410656,
-0.016347195953130722,
-0.01713872142136097,
0.005595644470304251,
0.014247455634176731,
-0.020073961466550827,
-0.01857885904610157,
0.0028005705680698156,
-0.050657618790864944,
-0.08680394291877747,
-0.010130424983799458,
0.010702081955969334,
-0.023218076676130295,
0.018831705674529076,
-0.014874080196022987,
0.019436344504356384,
0.02603238821029663,
-0.007393066305667162,
-0.009163005277514458,
0.04907457157969475,
0.016193289309740067,
0.001643514377065003,
0.010790029540657997,
0.020227869972586632,
0.019249456003308296,
-0.026516098529100418,
-0.008228565566241741,
-0.018820712342858315,
-0.014918053522706032,
0.02695583365857601,
-0.012059767730534077,
0.019260449334979057,
0.01725964993238449,
-0.011685991659760475,
0.02122826874256134,
-0.015027987770736217,
-0.023218076676130295,
0.017303623259067535,
-0.042412564158439636,
-0.0019925551023334265,
-0.017193688079714775,
-0.015775538980960846,
-0.027373583987355232,
0.014511297456920147,
-0.0019829359371215105,
-0.00017108490283135325,
0.01061413437128067,
-0.005120179615914822,
0.03262843191623688,
-0.021294230595231056,
-0.010630624368786812,
0.01754547841846943,
0.04111534357070923,
-0.017413556575775146,
-0.0021107341162860394,
-0.021558072417974472,
-0.025284836068749428,
0.011916853487491608,
0.008965123444795609,
0.017985213547945023,
-0.032826315611600876,
0.01908455416560173,
-0.011064864695072174,
0.002007670933380723,
0.012873279862105846,
0.01897462084889412,
0.02757146582007408,
-0.007013794034719467,
-0.001756196841597557,
-0.004633720964193344,
-0.03172697499394417,
-0.009899563156068325,
-0.021393170580267906,
0.002549096243456006,
-0.01520388200879097,
0.02090946026146412,
-0.015775538980960846,
0.006057367194443941,
-0.021459130570292473,
0.02693384699523449,
0.0005489832838065922,
-0.02317410334944725,
-0.0036250760313123465,
-0.008470420725643635,
-0.013335002586245537,
0.017798326909542084,
-0.029726173728704453,
-0.03196882829070091,
0.01357685774564743,
-0.004771138541400433,
0.0013274538796395063,
-0.001053305808454752,
-0.04744754731655121,
0.002447407227009535,
0.02093144692480564,
-0.0018881176365539432,
0.014731165952980518,
0.02959425188601017,
0.003762493608519435,
0.023525891825556755,
-0.032518498599529266,
0.007794325705617666,
0.0390046089887619,
0.027505503967404366,
-0.01126824226230383,
-0.017523491755127907,
-0.0002557684783823788,
-0.005733062047511339,
-0.015401763841509819,
-0.026076361536979675,
-0.012983214110136032,
-0.0060683609917759895,
-0.010207378305494785,
0.012400563806295395,
-0.0018468924099579453,
0.024735165759921074,
-0.013038180768489838,
0.015423750504851341,
-0.044963035732507706,
0.006766442209482193,
0.009960026480257511,
0.002562838140875101,
0.0030259352643042803,
0.037003807723522186,
-0.01929342932999134,
0.009086051024496555,
-0.0035920958034694195,
0.016589051112532616,
-0.03854288533329964,
-0.0013542503584176302,
0.03623427078127861,
0.011664004996418953,
-0.03388168290257454,
0.02807716280221939,
0.036190297454595566,
-0.02387768030166626,
-0.007068760693073273,
-0.031067369505763054,
-0.009569761343300343,
0.000648954592179507,
-0.03388168290257454,
0.02409754879772663,
0.015654612332582474,
0.015115935355424881,
0.003454678226262331,
0.02245953120291233,
-0.04236859083175659,
0.008272538892924786,
0.0011886621359735727,
-0.002450155559927225,
0.011070361360907555,
-0.019425351172685623,
-0.032056774944067,
-0.01868879236280918,
0.0069038597866892815,
0.016468124464154243,
0.04144514352083206,
0.0067609455436468124,
-0.0040867989882826805,
0.00030128806247375906,
-0.04823907092213631,
-0.013302022591233253,
0.023240063339471817,
-0.008228565566241741,
0.0015500704757869244,
0.016391169279813766,
-0.005054219160228968,
0.019205482676625252,
0.023306023329496384,
0.014269442297518253,
-0.02093144692480564,
0.014841100201010704,
-0.024251455441117287,
0.01815011538565159,
-0.021371183916926384,
-0.011147314682602882,
0.1058885008096695,
-0.026274243369698524,
-0.011894866824150085,
0.013851692900061607,
-0.005991406738758087,
-0.004952529910951853,
0.03625625744462013,
-0.008338499814271927,
0.02052469179034233,
-0.011971820145845413,
0.022624431177973747,
-0.01504997443407774,
0.04551270604133606,
0.014984014444053173,
0.043423958122730255,
-0.020436743274331093,
0.02378973364830017,
0.03845493867993355,
-0.0047106752172112465,
-0.019326409325003624,
0.015610638074576855,
0.02112932875752449,
-0.014005600474774837,
0.009591748006641865,
-0.03695983439683914,
0.0022275391966104507,
0.0020612638909369707,
-0.0041692499071359634,
-0.013708778657019138,
-0.012488510459661484,
0.0008966497844085097,
0.006744455546140671,
0.034035589545965195,
-0.008607838302850723,
-0.00106567342299968,
-0.029264450073242188,
-0.009740158915519714,
-0.01147711742669344,
0.005400511436164379,
0.017468523234128952,
0.0018386474112048745,
-0.0031386178452521563,
0.006464123260229826,
0.01244453713297844,
0.017083754763007164,
0.024647219106554985,
-0.035046983510255814,
0.014852093532681465,
0.011235262267291546,
-0.01570957899093628,
0.006442136596888304,
-0.002704378217458725,
0.011141818016767502,
-0.02245953120291233,
-0.051581066101789474,
-0.005331802647560835,
0.00009602054342394695,
-0.011587051674723625,
0.004529283847659826,
-0.0274395439773798,
-0.017820313572883606,
0.014621231704950333,
0.004457826726138592,
-0.02141515724360943,
0.015797525644302368
] | 2025-01-11 | 266 | 39796666 | [
"Cell therapies",
"effective cell therapy",
"immune effector cells",
"antitumor immune cells",
"NK cells",
"additional cell therapy platforms",
"immunosuppressive cells",
"Induced pluripotent stem cells",
"advanced cancers",
"most other solid tumors",
"several hematologic cancers",
"TCR-T cells",
"Effective treatments",
"lung cancers",
"CAR-T cells",
"advanced melanoma",
"clinical trial data",
"antitumor immune responses",
"recent basic scientific advances",
"Thoracic malignancies",
"thoracic malignancies",
"ongoing trials",
"advanced disease",
"malignant pleural mesothelioma",
"treatments",
"T cell receptor-engineered (TCR-T) cells",
"high morbidity",
"great promise",
"Obstacles",
"both NK and T cell-based therapies"
] | [
"CAR-T cells",
"NK cells",
"cell therapy",
"lung cancer",
"mesothelioma"
] | 0 | 10.3390/cancers17010035
10.1016/S0140-6736(21)00312-3
10.1200/OP.21.00426
10.1016/j.ccell.2020.07.013
10.1182/blood.2022016205
10.1126/science.aaa4967
10.1056/NEJM198512053132327
10.1056/NEJM198704093161501
10.1126/science.3489291
10.1056/NEJM198812223192527
10.1136/jitc-2021-002723
10.1038/s41571-023-00832-4
10.1056/NEJMoa2210233
10.1056/NEJMoa2314390
10.1038/s41591-024-02875-1
10.1056/NEJMoa2210859
10.1038/s41586-023-05707-3
10.1126/sciadv.adf3700
10.1182/blood.2022016200
10.1016/j.jtho.2017.10.001
10.3390/biology12020287
10.7150/thno.43991
10.1016/j.ejps.2022.106331
10.3389/fonc.2023.1124039
10.3389/fimmu.2020.00099
10.1038/s41388-018-0187-2
10.1155/2021/5575260
10.1016/j.omto.2020.04.008
10.1016/j.tranon.2017.10.009
10.4049/jimmunol.2300618
10.3389/fimmu.2021.665970
10.3389/fimmu.2018.00947
10.1007/s00262-022-03275-5
10.1016/j.canlet.2017.02.015
10.1016/j.medj.2023.04.004
10.1002/ijc.28857
10.1038/s41586-023-06945-1
10.1073/pnas.2022410118
10.1016/j.cell.2017.10.001
10.1158/2767-9764.CRC-23-0259
10.1038/s41467-022-33968-5
10.1200/JCO.2023.41.16_suppl.e15181
10.1016/j.ccell.2019.02.003
10.1080/2162402X.2017.1284722
10.1038/s41389-020-00257-z
10.1016/j.ajpath.2018.05.014
10.18632/oncotarget.519
10.1186/1479-5876-11-187
10.1016/j.lungcan.2023.107356
10.3389/fimmu.2022.878365
10.3389/fonc.2022.1051497
10.1016/j.jtocrr.2023.100630
10.1097/JTO.0b013e3181560dcc
10.1016/0003-4975(94)00866-6
10.3389/fimmu.2022.869676
10.5301/JBM.2011.6291
10.1016/j.humpath.2006.03.014
10.1054/bjoc.2000.1251
10.1172/JCI166028
10.1158/1078-0432.CCR-20-1141
10.1038/s41467-023-42010-1
10.3389/fmed.2017.00018
10.3390/cancers15041171
10.1038/s41388-024-03060-x
10.18632/oncotarget.28132
10.1016/S0169-5002(01)00292-6
10.1007/s00262-010-0881-6
10.1016/j.jtcvs.2007.10.026
10.1038/ni1001-957
10.1126/scisignal.abe2606
10.1016/j.jaci.2022.09.022
10.1038/s41577-022-00732-1
10.1182/blood-2004-07-2974
10.1016/j.cell.2007.11.019
10.1038/nature06534
10.1126/science.1151526
10.1126/science.1172482
10.1016/S0092-8674(02)00680-3
10.1038/clpt.2010.341
10.1016/j.stem.2013.09.002
10.1038/nature22370
10.1016/j.stem.2012.12.006
10.1016/j.stem.2012.11.002
10.1016/j.stem.2013.03.001
10.1158/0008-5472.CAN-16-1149
10.1016/j.isci.2020.100998
10.1016/j.stemcr.2015.07.011
10.1016/j.stem.2018.10.005
10.1016/j.cell.2024.01.035
10.1182/blood.2022016204
10.1038/s41568-022-00491-0
10.1016/j.bbmt.2017.11.042
10.1182/blood.2019000621
10.1016/j.molimm.2004.07.034
10.4049/jimmunol.175.8.5095
10.1182/blood-2008-06-165225
10.1038/srep00213
10.5966/sctm.2012-0084
10.1002/stem.2230
10.1007/978-1-4939-9728-2_12
10.1016/j.stemcr.2017.10.020
10.1016/j.stem.2020.05.008
10.1038/ni.3470
10.1007/BF00199837
10.1016/S0140-6736(89)91609-7
10.1016/S0022-5223(95)70205-9
10.1097/00002371-199605000-00007
10.1002/(SICI)1097-0142(19960715)78:2<244::AID-CNCR9>3.0.CO;2-L
10.1097/00002371-200001000-00019
10.1038/s41591-021-01462-y
10.1158/2159-8290.CD-23-1334
10.1126/science.abl5447
10.1007/s00262-024-03710-9
10.1038/s41587-024-02232-0
10.1016/j.immuni.2024.08.014
10.1038/s41467-017-01460-0
10.1007/s11427-016-5023-8
10.1016/j.annonc.2020.10.474
10.1158/2159-8290.CD-21-0407
10.1007/s00432-021-03613-7
10.1093/annonc/mdz448
10.1158/1538-7445.AM2018-CT131
10.1158/2326-6066.CIR-13-0006
10.1016/j.ymthe.2019.07.015
10.1172/JCI83092
10.1038/s41591-023-02452-y
10.1056/NEJMoa2307980
10.1136/jitc-2021-003581
10.1038/s41591-022-02128-z
10.1200/JCO.2023.41.16_suppl.2547
10.1080/2162402X.2018.1532759
10.1182/blood-2013-03-490565
10.1126/scitranslmed.3006034
10.1007/s00262-010-0904-3
10.1016/j.jcyt.2013.06.017
10.1007/s12026-017-8927-x
10.3389/fimmu.2022.1074906
10.1172/JCI132712
10.4143/crt.2021.986
10.1111/1759-7714.14523
10.1136/jitc-2022-SITC2022.0755
10.1016/j.annonc.2022.01.025
10.1186/s13045-020-01024-8
10.3390/cancers12092659
10.1158/1078-0432.CCR-15-2710
10.3389/fimmu.2022.1039969
10.1182/blood-2013-10-533398
10.3390/cells12131716
10.1007/s11523-015-0391-8
10.1136/jitc-2023-007280
10.1038/s43018-021-00244-2
10.1172/JCI83416
10.1038/s41573-021-00189-2
10.1038/s41587-019-0192-1
10.1038/s41590-020-0676-7
10.1126/scitranslmed.abg3072
10.1016/j.ymthe.2018.09.008
10.1172/JCI87624
10.1126/scitranslmed.3010162
10.1158/1078-0432.CCR-11-0351
10.3390/ijms24065424
10.1038/s41467-022-29647-0
10.1038/nbt.4086
10.1038/s41563-024-01825-z
10.1038/s41467-023-40850-5
10.3389/fimmu.2023.1172681
10.1038/nm.3833
10.1158/2159-8290.CD-20-0672
10.18632/oncotarget.23469
10.1016/j.ymthe.2018.05.003
10.1172/jci.insight.133977
10.1016/j.chembiol.2023.10.024
10.1158/0008-5472.CAN-13-1816
10.1007/s00262-023-03496-2
10.1158/0008-5472.CAN-13-3583
10.1172/JCI89455
10.1038/s41467-021-23331-5
10.1038/s41587-023-02060-8
10.1158/2326-6066.CIR-21-0536
10.1038/s41467-023-40115-1
10.1084/jem.20192203
10.1158/1078-0432.CCR-23-1872
10.1016/j.celrep.2017.09.002
10.1016/j.celrep.2017.11.063
10.1038/s41587-019-0398-2
10.1126/science.aba1624
10.1158/0008-5472.CAN-22-2220
10.1182/blood-2011-10-386482
10.1126/scitranslmed.abg8693
10.1182/blood-2013-10-532531
10.1084/jem.20050732
10.1016/j.ccell.2020.11.005
10.3389/fimmu.2022.816761
10.1371/annotation/5c756e7d-6e97-416f-836a-dced97cf46af
10.1016/j.cell.2021.08.004
10.1016/j.cell.2024.08.029
10.1038/s41467-022-35583-w
10.1038/s41586-024-07018-7
10.1016/j.cell.2024.04.015
10.1126/science.abb9847
10.1038/s41586-024-07242-1
10.1038/s41586-024-07300-8
10.1084/jem.20232368
10.1016/j.cmet.2015.11.002
10.3390/cancers11050602
10.1038/srep39833
10.1158/0008-5472.CAN-23-1038
10.1016/j.xcrm.2021.100227
10.1038/s41577-020-0306-5
10.1186/s40425-019-0685-y
10.1016/j.immuni.2023.09.001
10.1084/jem.20150304
10.3390/biomedicines5010002
10.1016/j.cellimm.2020.104041
10.1158/0008-5472.CAN-14-0697
10.4161/21505594.2014.988098
10.1126/scitranslmed.aaz1863
10.1126/scitranslmed.abn2231
10.1126/science.aav8692
10.1016/j.cell.2023.06.002
10.1126/science.aay5967
10.1038/s41467-018-05072-0
10.1158/1078-0432.CCR-16-2680
10.1038/s41587-024-02161-y
10.1016/j.ccell.2022.03.012
10.1038/s41467-024-46906-4
10.1056/NEJMoa1113205
10.1038/nature10803
10.1038/s41586-019-1032-7
10.1016/j.cell.2023.06.020
10.1158/1078-0432.CCR-23-2905
10.1038/s41551-021-00820-y
10.1136/jitc-2023-008645
10.1136/jitc-2021-003826
10.5582/bst.2018.01048
10.1182/blood.2024024523
10.1038/s41408-021-00508-1
10.1038/s41587-023-02085-z
10.1056/NEJMoa1609279
10.1056/NEJMoa2119662
10.1038/s41541-023-00713-y
10.1073/pnas.2312057120
10.1038/s41467-024-46367-9
10.1073/pnas.2216697120
10.1038/nature14001
10.1080/2162402X.2023.2182058
10.1038/s41392-020-00348-8
10.1126/scitranslmed.aaz5618
10.1182/blood-2013-08-519199
10.1172/JCI123955
10.1182/blood.2020007748
10.1016/j.cell.2018.10.014
10.1136/jitc-2023-007502
10.1126/science.aao0505
10.1158/2326-6066.CIR-19-0483
10.1038/s41467-024-46778-8
10.1016/j.cell.2022.03.030
10.1200/JCO.2024.42.16_suppl.e14518
10.1002/JLB.5MA0122-467R
10.1016/j.molimm.2020.04.016
10.1136/jitc-2021-003715
10.1016/j.ebiom.2019.01.031
10.1158/2326-6066.CIR-18-0572
10.1073/pnas.0813192106
10.1126/scitranslmed.aaf2341
10.1158/1538-7445.AM2022-CT540
10.1073/pnas.1110900108
10.1016/j.immuni.2015.02.008
10.1158/0008-5472.CAN-16-0839
10.1158/2326-6066.CIR-17-0498
10.1016/j.stem.2021.08.013
10.1136/jitc-2023-007955
10.1038/s41587-020-0462-y | [
"Erickson",
"Manning",
"Kumar",
"Patel"
] | [
"Internal Medicine Residency Program, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.",
"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.",
"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA.",
"Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA."
] | [
"39796666",
"34273294",
"34491782",
"32822573",
"36327161",
"25838374",
"3903508",
"3493432",
"3489291",
"3264384",
"34301811",
"37904019",
"36477031",
"38477966",
"38454126",
"37018492",
"36813894",
"36791198",
"36416736",
"29107016",
"36829563",
"32685008",
"36384203",
"36923424",
"32117253",
"29622795",
"34189144",
"32405534",
"29132013",
"38214607",
"34475869",
"29770138",
"35988132",
"28223167",
"37172578",
"24710653",
"38383621",
"33731480",
"29107330",
"38380966",
"36261437",
"30889382",
"28405515",
"32792499",
"29935166",
"22547449",
"23937772",
"37660479",
"35464460",
"36620607",
"38361739",
"17909358",
"7847958",
"35572601",
"21279958",
"16867862",
"10901371",
"36951942",
"32873573",
"37828002",
"28337438",
"36831514",
"38773263",
"34917263",
"11750709",
"20567822",
"18374762",
"11577349",
"34429382",
"36195172",
"35637393",
"15632206",
"18035408",
"18157115",
"18029452",
"19325077",
"11955444",
"21389982",
"24094326",
"28514439",
"23290135",
"23290140",
"23523177",
"27872100",
"32259478",
"26321144",
"30449714",
"38387457",
"36223560",
"35879429",
"29247781",
"31856277",
"15607806",
"16210613",
"19365083",
"22355727",
"23515118",
"26503833",
"31396935",
"29173894",
"32531207",
"27213690",
"3493073",
"2564111",
"7776685",
"8811497",
"8673999",
"10687149",
"34385708",
"38563600",
"35113651",
"38727812",
"38714897",
"39276771",
"29170503",
"26968708",
"33098996",
"34266984",
"34032893",
"24777247",
"31420241",
"27454297",
"37501016",
"37861218",
"35086946",
"36624315",
"30713784",
"23770775",
"23926201",
"20703455",
"23645763",
"24094496",
"28508945",
"36569881",
"32027620",
"34856706",
"35670036",
"33514401",
"32961861",
"26847056",
"36685519",
"24652987",
"37443750",
"26566946",
"38056893",
"34746799",
"27427982",
"33972771",
"31332324",
"32424363",
"35044789",
"30415658",
"28436934",
"25378643",
"21610146",
"36982500",
"35443752",
"29505028",
"38448658",
"37607999",
"37251405",
"25849134",
"33127846",
"29423109",
"29807781",
"31999649",
"37989314",
"24247719",
"37505292",
"25377469",
"28165340",
"34050151",
"38168996",
"35696724",
"37550294",
"33156338",
"37910044",
"28954221",
"29241547",
"32015548",
"36520915",
"37115855",
"22555974",
"34349035",
"24719405",
"16203864",
"33357452",
"35250995",
"22815789",
"34464586",
"39276774",
"36732507",
"38326614",
"38723627",
"33303615",
"38600376",
"38600391",
"38530240",
"26674251",
"31052261",
"28106050",
"37874330",
"33948568",
"32433532",
"31391096",
"37776850",
"26527801",
"28536345",
"31983398",
"25060519",
"25949885",
"32878978",
"35417192",
"31296767",
"37413990",
"31896660",
"30006565",
"27827318",
"38454173",
"35452604",
"38627362",
"22397650",
"22318517",
"30894752",
"37490916",
"38190111",
"35087171",
"38816232",
"35091455",
"29899195",
"38861668",
"34162832",
"38212493",
"27959684",
"35648703",
"37607971",
"38085776",
"38459027",
"36802421",
"25428506",
"36875551",
"33122640",
"33148626",
"24326534",
"30860984",
"32902645",
"30503213",
"38081778",
"29599246",
"32209637",
"38519469",
"35447071",
"35088475",
"32388482",
"35288464",
"30665853",
"30651290",
"19181844",
"27655849",
"21825173",
"25786176",
"27503932",
"29784636",
"34525347",
"38007241",
"32361713"
] | [] | 10.491421 | 4.53794 |
39794936 | 44 | Preclinical model for evaluating human TCRs against chimeric syngeneic tumors. | The adoptive cell transfer (ACT) of T cell receptor (TCR)-engineered T cells targeting the HLA-A2-restricted epitope NY-ESO-1
We compared the function of a supraphysiological affinity A2/NY TCR (wtc51m), a computationally designed TCR in an optimal affinity range (DMβ), and a near non-binding TCR (V49I), engineered in both primary human and murine T cells by lentiviral and retroviral transduction, respectively. We evaluated a variety of strategies to stably express A2Kb:NY on the surface of mouse tumor cell lines including B16 melanoma, ultimately achieving success with an SCT comprising human β2m fused by GS linkers to both the NY-peptide and to α1 of the HLA complex. ACT studies were performed in B16-A2Kb:NY tumor-bearing, non-preconditioned immune-competent HLA-A*0201/H-2Kb (A2Kb) transgenic C57BL/6 mice and tumors characterized post-transfer.
We observed significantly improved function of DMβ-T cells as well as superior infiltration and tumor control upon ACT as compared to the control TCR-T cells. Moreover, with our chimeric syngeneic tumor model, we were able to track dynamic and favorable changes in the TME upon DMβ-T cell transfer.
We have developed a robust, simple, and inexpensive preclinical strategy for evaluating human TCRs in the context of a fully competent murine immune system that can aid in the development of coengineered TCR-T cells and combination treatments translated to the clinic. | [
0.00730766961351037,
-0.01680149883031845,
0.007037470117211342,
0.03971933573484421,
-0.023949505761265755,
-0.011630862951278687,
0.016690963879227638,
0.04875873774290085,
0.0012450672220438719,
-0.004507419653236866,
0.0024287255946546793,
-0.0223037451505661,
-0.03335736319422722,
0.0030811959877610207,
0.013743331655859947,
-0.05536634474992752,
0.0312203299254179,
-0.02102643810212612,
-0.016850626096129417,
0.006576902698725462,
0.05610325187444687,
0.023961788043379784,
-0.012699378654360771,
-0.0019789047073572874,
-0.019871948286890984,
-0.011594017036259174,
0.013645077124238014,
-0.026209356263279915,
-0.0014561606803908944,
-0.04038255289196968,
0.009843860752880573,
-0.020977310836315155,
-0.0021109338849782944,
-0.00730766961351037,
-0.04942195490002632,
0.045000508427619934,
0.011538748629391193,
0.026602374389767647,
-0.010519360192120075,
0.011372944340109825,
0.025939157232642174,
-0.029771078377962112,
0.020584292709827423,
0.0680902898311615,
-0.07452595233917236,
-0.021677372977137566,
-0.03854028135538101,
-0.03930175304412842,
0.010826405137777328,
0.0021677373442798853,
0.01739102602005005,
-0.0026544034481048584,
-0.03067993000149727,
0.0669112354516983,
-0.044165343046188354,
0.025914592668414116,
-0.0057202475145459175,
0.03979302570223808,
-0.02699539065361023,
0.017427871003746986,
-0.013215214014053345,
0.0033897762186825275,
0.06352145969867706,
-0.0020264966879040003,
-0.025939157232642174,
-0.011778243817389011,
-0.04124227538704872,
0.01511889323592186,
0.006859384011477232,
-0.0013870755210518837,
0.0027895034290850163,
-0.012625687755644321,
-0.00663831178098917,
-0.01962631195783615,
0.039473697543144226,
0.012079148553311825,
-0.006008869502693415,
0.026184793561697006,
-0.0030811959877610207,
-0.033971451222896576,
0.007055892609059811,
-0.029156988486647606,
-0.03930175304412842,
-0.04404252767562866,
0.02952544204890728,
-0.016875190660357475,
0.009229770861566067,
-0.02643042802810669,
-0.038368336856365204,
-0.020977310836315155,
0.042863473296165466,
0.025644393637776375,
-0.0257180854678154,
0.033701252192258835,
0.028469206765294075,
0.010316709987819195,
-0.023924941197037697,
-0.062489788979291916,
0.04293716326355934,
0.01320293266326189,
0.06411098688840866,
-0.017268206924200058,
0.006478648167103529,
-0.0008658667211420834,
0.02699539065361023,
-0.006294421385973692,
-0.009905270300805569,
0.020829929038882256,
0.024968894198536873,
0.023544207215309143,
0.06922021508216858,
-0.009585943073034286,
0.02332313358783722,
0.009868424385786057,
0.010543923825025558,
-0.06003342941403389,
-0.011569453403353691,
-0.02515312097966671,
0.012085288763046265,
-0.003577073570340872,
-0.006318985018879175,
0.03576459363102913,
0.04087382182478905,
-0.03546983376145363,
0.0014830271247774363,
-0.0026743614580482244,
0.07329776883125305,
-0.03718928247690201,
-0.06450400501489639,
-0.01767350733280182,
0.07541023939847946,
0.005935178603976965,
0.00299982912838459,
0.021947572007775307,
-0.049667589366436005,
-0.020965028554201126,
-0.028199007734656334,
0.015094329603016376,
-0.020240401849150658,
0.020670264959335327,
0.0016242677811533213,
-0.020375503227114677,
-0.009518393315374851,
-0.013866149820387363,
-0.049520209431648254,
-0.03809813782572746,
-0.024047760292887688,
0.04276521876454353,
0.018422696739435196,
0.03998953476548195,
0.006085630971938372,
0.04379688948392868,
0.03814726322889328,
-0.0025991355068981647,
-0.00946312490850687,
-0.041463349014520645,
0.0023918801452964544,
0.06199851632118225,
-0.025054868310689926,
-0.07796484977006912,
-0.007283105980604887,
0.03377494215965271,
-0.00589526304975152,
0.0069514974020421505,
0.021812472492456436,
0.005704895127564669,
-0.015425938181579113,
0.023937223479151726,
-0.08273018896579742,
0.019601749256253242,
0.008683230727910995,
-0.02219320833683014,
-0.039768461138010025,
0.0024578948505222797,
-0.049643028527498245,
-0.044165343046188354,
-0.0016718597617000341,
-0.001897537731565535,
-0.03630499541759491,
-0.02756035514175892,
0.0159786194562912,
0.043993398547172546,
0.029697386547923088,
0.0008436059579253197,
-0.00805071834474802,
0.0031963379587978125,
0.010801841504871845,
0.023065216839313507,
-0.007522601168602705,
-0.022230053320527077,
0.010286005213856697,
0.007749814540147781,
0.03193267434835434,
-0.03377494215965271,
-0.015843519940972328,
-0.01284676045179367,
0.02584090270102024,
0.02898504212498665,
-0.0008819865761324763,
-0.03827008232474327,
0.032816965132951736,
-0.04522157832980156,
-0.02191072702407837,
-0.029328932985663414,
-0.0182139053940773,
0.013325750827789307,
-0.0061501101590693,
0.054727692157030106,
0.006914651952683926,
0.011772103607654572,
0.06018080934882164,
0.004703928716480732,
0.005907544866204262,
0.04038255289196968,
-0.01906134933233261,
-0.021419456228613853,
-0.038761354982852936,
0.011391367763280869,
0.008621822111308575,
0.028051625937223434,
-0.02375299669802189,
-0.022205490618944168,
-0.0094754071906209,
0.003801216371357441,
-0.03141683712601662,
0.04630237817764282,
-0.00589526304975152,
-0.05187831446528435,
-0.01936839520931244,
-0.048365719616413116,
0.006171603221446276,
0.022672198712825775,
-0.008431454189121723,
-0.02515312097966671,
-0.02218092605471611,
0.03126945719122887,
0.015204865485429764,
-0.01440654881298542,
0.03198179975152016,
-0.06676385551691055,
0.02898504212498665,
-0.0031088299583643675,
0.009168362244963646,
0.020854491740465164,
0.00024294931790791452,
-0.012809915468096733,
0.010820263996720314,
-0.09029577672481537,
0.0003156805760227144,
-0.0019574114121496677,
0.006199237424880266,
-0.008806048892438412,
-0.009137657471001148,
-0.005247398279607296,
0.006011940073221922,
0.03470836207270622,
0.014160912483930588,
-0.00019996301853097975,
-0.024367086589336395,
0.009960537776350975,
-0.03193267434835434,
-0.0014661395689472556,
0.0018054242245852947,
-0.0003064692427869886,
-0.05556285381317139,
0.013534541241824627,
0.0216282457113266,
0.043281055986881256,
0.03868766129016876,
0.03365212678909302,
-0.012122134678065777,
-0.005486893001943827,
0.00008933088975027204,
-0.014799566008150578,
-0.040186043828725815,
-0.013387159444391727,
-0.03335736319422722,
0.045025069266557693,
-0.030606240034103394,
0.019589466974139214,
-0.03618217632174492,
-0.03311172500252724,
0.0020832999143749475,
-0.03785249963402748,
-0.047825321555137634,
-0.006472507491707802,
-0.034536413848400116,
-0.0015060554724186659,
-0.008572694845497608,
-0.03529788553714752,
0.018471824005246162,
0.011980894021689892,
0.006168533116579056,
-0.03210461884737015,
-0.0010009665274992585,
0.03485574200749397,
-0.012773069553077221,
-0.02940262481570244,
-0.0002216480643255636,
0.010464091785252094,
-0.021136974915862083,
0.014775002375245094,
0.032129183411598206,
-0.012895887717604637,
0.007068174425512552,
0.03605935722589493,
0.009199066087603569,
-0.004510490223765373,
0.010617613792419434,
0.031687039881944656,
0.005671120248734951,
-0.016052309423685074,
-0.015659291297197342,
0.028935914859175682,
0.025398757308721542,
-0.030188659206032753,
0.01852095127105713,
-0.015229429118335247,
0.011630862951278687,
-0.006110194604843855,
-0.039498262107372284,
-0.03922806307673454,
-0.044140782207250595,
0.005889121908694506,
0.0035248759668320417,
-0.0029660542495548725,
-0.018017398193478584,
-0.01518030185252428,
0.0426669642329216,
-0.010568487457931042,
0.0338977612555027,
-0.04566372558474541,
0.06548654288053513,
-0.04382145404815674,
0.014578494243323803,
-0.018287597224116325,
-0.012760788202285767,
-0.011538748629391193,
0.01694888062775135,
0.056741904467344284,
-0.04340387508273125,
0.003346789861097932,
-0.055857617408037186,
0.003976231906563044,
0.0483165942132473,
0.004363108891993761,
0.011778243817389011,
0.025767210870981216,
-0.01919645071029663,
0.05236958712339401,
-0.006945356726646423,
0.01979825831949711,
0.025251375511288643,
0.029918460175395012,
-0.011796667240560055,
-0.01406265888363123,
0.012361629866063595,
-0.061507243663072586,
0.021222947165369987,
0.011729116551578045,
0.002173878252506256,
0.01468903012573719,
-0.0024901344440877438,
0.0035954962950199842,
0.03699277341365814,
0.053597766906023026,
-0.025619830936193466,
0.04347756505012512,
0.0054377662017941475,
-0.050085172057151794,
-0.014738157391548157,
0.005271961912512779,
-0.0211861003190279,
0.04310911148786545,
-0.05910000950098038,
0.026528682559728622,
0.036943648010492325,
-0.009487688541412354,
0.03205549344420433,
0.012822196818888187,
0.06091771647334099,
-0.015647010877728462,
-0.016604989767074585,
-0.05934564769268036,
-0.017550688236951828,
0.016494454815983772,
0.03748404607176781,
-0.007805082481354475,
-0.07737532258033752,
0.026651501655578613,
-0.002523909555748105,
-0.04347756505012512,
-0.027241026982665062,
-0.0043938132002949715,
-0.04423903673887253,
0.028321824967861176,
0.006239153444766998,
0.04932370036840439,
0.04504963383078575,
0.018312159925699234,
-0.02246340736746788,
-0.02881309762597084,
-0.04222482070326805,
-0.08218979090452194,
-0.006392675917595625,
-0.030065840110182762,
0.0029568427707999945,
0.015929492190480232,
0.011526467278599739,
0.01397668570280075,
-0.01977369375526905,
-0.020449193194508553,
0.03601023182272911,
0.013509977608919144,
0.03465923294425011,
0.009143798612058163,
-0.026061974465847015,
0.059542156755924225,
0.010445669293403625,
0.005692613311111927,
-0.03279240056872368,
-0.036796264350414276,
0.0006413401570171118,
-0.04308454692363739,
0.004762267228215933,
-0.016482172533869743,
0.02500574104487896,
0.03831920772790909,
-0.004734633024781942,
-0.02812531776726246,
-0.009469266049563885,
0.046154994517564774,
0.0012205037055537105,
-0.008916584774851799,
-0.02374071441590786,
0.07241348177194595,
-0.03320997953414917,
0.018656050786376,
-0.026651501655578613,
0.021984418854117393,
-0.023372260853648186,
0.007012906484305859,
-0.05910000950098038,
-0.04757968336343765,
0.0075164600275456905,
0.0309255663305521,
-0.030458858236670494,
-0.013681923039257526,
0.013546822592616081,
0.024539031088352203,
0.02726559154689312,
-0.03163791075348854,
-0.008996416814625263,
0.02559526637196541,
-0.012005457654595375,
0.009678056463599205,
0.03797531872987747,
-0.04323192685842514,
0.016580427065491676,
0.007264683488756418,
0.045123323798179626,
-0.02964825928211212,
-0.025116275995969772,
-0.051141407340765,
-0.028076190501451492,
0.06465138494968414,
0.051141407340765,
-0.014234603382647038,
0.03564177826046944,
-0.01314152404665947,
-0.0009587478125467896,
-0.03669801354408264,
-0.0008105986635200679,
0.021542273461818695,
-0.029009606689214706,
0.011501903645694256,
0.04347756505012512,
-0.0078112236224114895,
0.007878772914409637,
-0.022500254213809967,
0.01532768364995718,
-0.044558361172676086,
0.0014338998589664698,
-0.002163131721317768,
0.03940000757575035,
0.043453000485897064,
-0.010267582722008228,
0.00919292587786913,
0.01767350733280182,
0.05497332662343979,
0.013374878093600273,
-0.0032454649917781353,
0.02714277245104313,
-0.012085288763046265,
0.04097207635641098,
-0.01263797003775835,
0.05806833878159523,
-0.025091713294386864,
-0.045835670083761215,
0.019024504348635674,
-0.02682344615459442,
0.026307610794901848,
0.0003060854214709252,
0.01907363161444664,
0.03141683712601662,
0.03967020660638809,
0.03235025703907013,
0.0194789320230484,
-0.0034419738221913576,
0.02967282384634018,
-0.01002808753401041,
-0.004145106766372919,
0.013718768022954464,
-0.0217756275087595,
-0.0255707036703825,
-0.039768461138010025,
-0.031294021755456924,
0.03463466838002205,
-0.02756035514175892,
0.009942115284502506,
-0.03910524398088455,
-0.01809108816087246,
-0.04902893677353859,
-0.00395166827365756,
0.03038516826927662,
0.0011698412708938122,
-0.03011496737599373,
-0.031122075393795967,
-0.042740657925605774,
-0.028321824967861176,
-0.004390742629766464,
-0.014922384172677994,
0.04487768933176994,
0.048365719616413116,
-0.004624096676707268,
-0.02584090270102024,
-0.018471824005246162,
0.0523204579949379,
-0.018054243177175522,
-0.011489622294902802,
0.02401091530919075,
-0.0211861003190279,
0.05467856302857399,
-0.0073322332464158535,
0.015303120017051697,
0.013288904912769794,
0.002425655024126172,
-0.005130721256136894,
0.019429804757237434,
-0.013448568992316723,
0.00243486650288105,
-0.01579439267516136,
-0.0056004999205470085,
0.018680615350604057,
0.003838061820715666,
0.006159321404993534,
-0.01525399275124073,
-0.0576753206551075,
-0.011428212746977806,
-0.009217489510774612,
-0.03628043085336685,
0.0074734739027917385,
0.0047192806378006935,
-0.03011496737599373,
0.007719109766185284,
0.000993290450423956,
-0.01002808753401041,
0.0034542556386440992,
-0.030311476439237595,
0.03814726322889328,
-0.02458815835416317,
-0.008953430689871311,
0.0056649791076779366,
-0.021529991179704666,
0.015450501814484596,
0.008769203908741474,
-0.028370952233672142,
-0.024661850184202194,
-0.010992209427058697,
0.0008113662479445338,
-0.03406970575451851,
-0.018901687115430832,
-0.0486113540828228,
0.05099402368068695,
-0.022266900166869164,
0.018840277567505836,
-0.022230053320527077,
-0.012085288763046265,
-0.005775515455752611,
0.020866774022579193,
0.027756862342357635,
-0.014283730648458004,
0.017268206924200058,
0.025742648169398308,
-0.029697386547923088,
0.0051215095445513725,
0.017059417441487312,
-0.006349689327180386,
-0.01725592650473118,
-0.0480218306183815,
0.017452435567975044,
0.005431625060737133,
-0.0032423946540802717,
-0.029992150142788887,
-0.005668049678206444,
0.05929651856422424,
-0.01809108816087246,
-0.02261078916490078,
0.0015689997235313058,
-0.0063558304682374,
0.049643028527498245,
0.004145106766372919,
0.010494796559214592,
-0.004918859805911779,
0.022831862792372704,
0.013792458921670914,
-0.019663158804178238,
-0.005483822897076607,
0.034978561103343964,
-0.030851876363158226,
-0.03632955625653267,
-0.008044577203691006,
0.00039762319647707045,
0.016211973503232002,
-0.0021677373442798853,
-0.032841525971889496,
-0.03023778647184372,
0.008013873361051083,
-0.0064847893081605434,
0.01519258413463831,
-0.0016211973270401359,
-0.025202248245477676,
0.012496729381382465,
0.029476314783096313,
-0.005892192479223013,
-0.02036322094500065,
0.025251375511288643,
-0.006644452456384897,
0.00030666112434118986,
-0.006804116070270538,
-0.015241711400449276,
0.025472449138760567,
0.017489280551671982,
-0.006162391975522041,
0.01086939126253128,
0.004820605739951134,
-0.005342582240700722,
0.009530674666166306,
0.00020053873595315963,
-0.011722976341843605,
-0.034831177443265915,
-0.022365154698491096,
0.03141683712601662,
0.025619830936193466,
0.011372944340109825,
-0.0019036786397919059,
0.022549381479620934,
-0.030483422800898552,
0.04699015989899635,
0.03785249963402748,
-0.009825438261032104,
0.02501802146434784,
-0.02092818357050419,
0.03576459363102913,
-0.024354804307222366,
0.0006140898913145065,
-0.026897137984633446,
0.021714217960834503,
-0.006730425171554089,
-0.021284354850649834,
0.06931846588850021,
-0.005069312173873186,
0.01934383064508438,
0.015168020501732826,
0.012079148553311825,
0.02657780982553959,
-0.01639620028436184,
-0.0221563633531332,
-0.048537664115428925,
0.004151247441768646,
0.011458917520940304,
0.003053562017157674,
-0.032252002507448196,
-0.07182395458221436,
0.02149314619600773,
0.009733324870467186,
-0.004664012696594,
-0.024477623403072357,
-0.004651730880141258,
-0.028027063235640526,
0.0026943194679915905,
0.014222322031855583,
0.008020013570785522,
-0.029427187517285347,
0.007221696898341179,
-0.00394859816879034,
-0.002858588472008705,
0.0026114173233509064,
-0.00889816228300333,
-0.06170375272631645,
0.043453000485897064,
-0.0013840050669386983,
-0.0062667871825397015,
-0.01454164832830429,
-0.0048175351694226265,
-0.007946323603391647,
0.0049587758257985115,
-0.0185086689889431,
0.031858984380960464,
0.029476314783096313,
0.008032295852899551,
0.000682023586705327,
-0.02329857088625431,
-0.016727808862924576,
-0.03036060370504856,
-0.0025684309657663107,
-0.0031564219389110804,
0.038908734917640686,
0.0015904927859082818,
0.027314718812704086,
0.007283105980604887,
0.018827995285391808,
-0.0005453886114992201,
0.01173525769263506,
0.018545513972640038,
0.04197918623685837,
-0.06288280338048935,
0.03659975901246071,
0.005281173158437014,
-0.017710352316498756,
0.014934666454792023,
0.018275314942002296,
-0.019184168428182602,
0.003976231906563044,
-0.056987542659044266,
0.011256267316639423,
-0.03785249963402748,
-0.028051625937223434,
-0.020264966413378716,
0.011329958215355873,
0.037385791540145874,
-0.017550688236951828,
-0.0429617278277874,
0.04011235013604164,
-0.0021155397407710552,
0.02428111433982849,
0.027658607810735703,
0.016776936128735542,
0.019564904272556305,
-0.0010439527686685324,
-0.021824754774570465,
0.009358730167150497,
-0.04256870970129967,
-0.019724566489458084,
-0.02091590128839016,
0.011876498349010944,
0.006595325190573931,
0.0011214816477149725,
-0.024907486513257027,
0.004495137836784124,
-0.029132423922419548,
-0.00011456614447524771,
-0.011901061981916428,
0.002132427180185914,
-0.000559589418116957,
0.010709728114306927,
-0.02584090270102024,
0.006447943858802319,
-0.026798883453011513,
0.03716472163796425,
0.0012988001108169556,
-0.01129925437271595,
-0.011108886450529099,
-0.011551030911505222,
0.021972136572003365,
-0.008044577203691006,
-0.018594641238451004,
0.0010078750783577561,
0.02159140072762966,
0.012201965786516666,
0.00018825693405233324,
-0.00981929711997509,
0.005692613311111927,
-0.032841525971889496,
-0.01904906891286373,
-0.003171774325892329,
-0.02503030374646187,
0.018177060410380363,
-0.030827311798930168,
-0.018570078536868095,
-0.008105986751616001,
0.014111785218119621,
-0.03352930769324303,
0.030311476439237595,
0.001484562293626368,
-0.008069140836596489,
0.017685789614915848,
-0.11073268949985504,
-0.05315561965107918,
0.022094953805208206,
0.018570078536868095,
-0.015561037696897984,
-0.017870016396045685,
-0.014283730648458004,
-0.003168703755363822,
0.019024504348635674,
-0.01834900677204132,
-0.013657359406352043,
-0.000017978920368477702,
-0.0006359668332152069,
-0.025177685543894768,
0.007369078695774078,
-0.001782395876944065,
-0.044165343046188354,
-0.027363846078515053,
0.00016350143414456397,
0.013939840719103813,
-0.021370328962802887,
0.03967020660638809,
-0.00001974203041754663,
0.020277248695492744,
-0.04561459645628929,
0.034683797508478165,
-0.01782088913023472,
0.029992150142788887,
-0.028714843094348907,
-0.024489905685186386,
0.004185022786259651,
0.020240401849150658,
-0.011931766755878925,
0.041880931705236435,
-0.03141683712601662,
-0.025177685543894768,
0.015057483687996864,
0.024256549775600433,
0.01639620028436184,
0.019712286069989204,
-0.01570841856300831,
-0.026676064357161522,
0.008904303424060345,
0.0058614881709218025,
0.02616022899746895,
-0.018177060410380363,
-0.017710352316498756,
0.00799544993788004,
-0.01637163572013378,
-0.0005173707031644881,
0.035371579229831696,
-0.05028168112039566,
-0.03662431985139847,
0.015597883611917496,
-0.018570078536868095,
-0.05507158115506172,
0.02403547801077366,
0.004495137836784124,
0.015303120017051697,
0.010286005213856697,
-0.04679365083575249,
0.03266958147287369,
0.031023820862174034,
-0.014136348851025105,
-0.002242963295429945,
-0.0189508143812418,
-0.006217659916728735,
0.0615563690662384,
0.014357421547174454,
0.009641211479902267,
0.00840689055621624,
0.008443735539913177,
-0.0316624753177166,
0.007577869109809399,
0.022279180586338043,
-0.015769828110933304,
-0.029058733955025673,
0.007000624667853117,
-0.006208448670804501,
0.03311172500252724,
0.026381300762295723,
0.02387581579387188,
-0.014664466492831707,
0.015032920055091381,
-0.00938943400979042,
-0.006650593597441912,
0.020510602742433548,
0.024403931573033333,
0.029697386547923088,
-0.002795644337311387,
-0.002534656086936593,
-0.02091590128839016,
0.004740774165838957,
0.024698695167899132,
-0.0020065386779606342,
0.014566211961209774,
-0.030188659206032753,
-0.011624721810221672,
0.003540228120982647,
0.018987659364938736,
0.03502768650650978,
-0.014750438742339611,
-0.015880364924669266,
-0.013927558436989784,
-0.04283891245722771,
0.031883545219898224,
0.012472165748476982,
-0.01893853209912777,
-0.0214808639138937,
0.00561585184186697,
0.026111101731657982,
0.02500574104487896,
-0.0014745834050700068,
0.012521293014287949,
0.01004036981612444,
0.01962631195783615,
0.014590775594115257,
0.02613566629588604,
0.0022890199907124043,
0.0032423946540802717,
0.06022993475198746,
0.029844768345355988,
-0.03979302570223808,
-0.004762267228215933,
-0.0038503436371684074,
0.016887471079826355,
0.021984418854117393,
-0.013595949858427048,
-0.010519360192120075,
-0.017476998269557953,
0.02431795932352543,
0.012588842771947384,
0.03279240056872368,
-0.016629554331302643,
-0.027732299640774727,
0.029771078377962112,
0.02247568964958191,
0.06465138494968414,
0.016494454815983772,
0.008320918306708336,
-0.006804116070270538,
-0.021640527993440628,
-0.0035371577832847834,
-0.034953996539115906,
-0.002573036588728428,
-0.017440153285861015,
-0.06022993475198746,
0.006982202176004648,
-0.02456359565258026,
-0.00791561882942915,
-0.0015751405153423548,
0.010807981714606285,
0.02145630121231079,
0.029451750218868256,
-0.003838061820715666,
0.02234059013426304,
0.007166428957134485,
-0.001035509048961103,
0.0035095238126814365,
0.018877122551202774,
-0.015143456868827343,
0.026626937091350555,
-0.026946265250444412,
-0.01518030185252428,
0.0364278107881546,
-0.01455393061041832,
-0.047677937895059586,
0.01130539458245039,
0.023359978571534157,
0.0011230169329792261,
0.012011597864329815,
-0.033848635852336884,
0.02711820974946022,
0.00730766961351037,
-0.0257180854678154,
0.015904927626252174,
0.04691646620631218,
0.01017546933144331,
-0.0026528683956712484,
0.00294763152487576,
-0.005195200443267822,
0.00427713617682457,
0.040775567293167114,
0.009506111033260822,
0.02925524301826954,
-0.012551997788250446,
0.0018269174033775926,
-0.015241711400449276,
0.005290384404361248,
0.021505428478121758,
-0.016887471079826355,
-0.027584917843341827,
0.018815714865922928,
0.057871829718351364,
0.0059044742956757545,
-0.0004099050129298121,
-0.00763313751667738,
0.03208005428314209,
-0.028199007734656334,
-0.0312203299254179,
-0.04868504777550697,
0.034241653978824615,
0.012674815021455288,
-0.011673849076032639,
-0.021812472492456436,
-0.005029396153986454,
0.042445894330739975,
-0.03276783600449562,
-0.01993335783481598,
0.02584090270102024,
0.011894920840859413,
0.06725512444972992,
-0.0078112236224114895,
0.025791775435209274,
0.0285428985953331,
0.0014546253951266408,
0.007043611258268356,
-0.033381927758455276,
-0.00961050670593977,
-0.041586168110370636,
-0.05458030849695206,
-0.01369420439004898,
0.0005008670850656927,
0.01378017757087946,
0.014418830163776875,
0.003976231906563044,
0.03247307240962982,
0.0012565813958644867,
-0.015659291297197342,
0.026233920827507973,
-0.02484607696533203,
0.04153703898191452,
0.014959230087697506,
0.011489622294902802,
0.018471824005246162,
0.028076190501451492,
0.005800079088658094,
-0.04239676520228386,
-0.003438903484493494,
-0.005305736791342497,
0.055317215621471405,
0.005876840092241764,
-0.012521293014287949,
-0.004943423438817263,
-0.0251285582780838,
0.011882639490067959,
0.028911352157592773,
0.014578494243323803,
-0.021824754774570465,
0.03009040467441082,
0.0091806435957551,
-0.029009606689214706,
0.008916584774851799,
0.03303803503513336,
0.0283955167979002,
0.032816965132951736,
-0.015769828110933304,
0.038761354982852936,
0.04281434789299965,
-0.0012343206908553839,
0.006558480206876993,
-0.002497810637578368,
0.0330134741961956,
-0.0038227096665650606,
0.00966577511280775,
-0.010402683168649673,
0.004384601954370737,
0.0010900095803663135,
-0.004519701469689608,
0.029132423922419548,
0.024354804307222366,
0.002253709826618433,
0.024821514263749123,
0.002906180452555418,
0.008394609205424786,
-0.028370952233672142,
0.026111101731657982,
-0.029476314783096313,
0.047825321555137634,
-0.010697445832192898,
-0.010316709987819195,
-0.013878431171178818,
0.0020940464455634356,
0.013190650381147861,
0.014590775594115257,
-0.018582360818982124,
-0.021849317476153374,
-0.027511227875947952,
0.007246260531246662,
-0.01086939126253128,
-0.03262045606970787,
0.03095013089478016,
-0.008247227407991886,
-0.023617897182703018,
-0.027241026982665062,
0.003862625453621149,
-0.015168020501732826,
0.01278535183519125,
0.005462329369038343,
-0.00012953458644915372,
0.022401999682188034,
0.037803374230861664,
-0.02064570225775242,
-0.020829929038882256,
0.02908329665660858,
-0.02994302287697792,
-0.02060885727405548,
-0.038220953196287155,
0.07447682321071625,
0.002421049401164055,
-0.06700948625802994,
-0.002008073963224888,
0.008548131212592125,
-0.009113093838095665,
-0.010961504653096199,
0.02134576439857483,
0.0021585258655250072,
0.007719109766185284,
0.004624096676707268,
0.025202248245477676,
-0.00889816228300333,
-0.005846135783940554,
0.007319951429963112,
-0.006199237424880266,
-0.01922101341187954,
0.004160459153354168,
0.010015806183218956,
-0.02726559154689312,
0.006705861538648605,
-0.008284072391688824,
0.017968270927667618,
-0.014160912483930588,
-0.0032423946540802717,
0.03323454409837723,
0.004427588079124689,
0.006349689327180386,
0.004221867769956589,
-0.017120826989412308,
0.011827371083199978,
-0.017169952392578125,
0.005253538955003023,
-0.01655586250126362,
-0.025791775435209274,
0.009309602901339531,
-0.020449193194508553,
0.037655990570783615,
-0.000273078097961843,
0.0039025412406772375,
-0.02797793596982956,
-0.021296637132763863,
0.057282306253910065,
-0.020117584615945816,
-0.005628133658319712,
0.04981497302651405,
0.023802123963832855,
0.00046133503201417625,
-0.002325865440070629,
0.010537782683968544,
-0.002414908492937684,
0.0011360662756487727,
-0.03831920772790909,
0.01525399275124073,
0.003392846556380391,
0.006644452456384897,
-0.007577869109809399,
0.000794478808529675,
-0.023900378495454788,
-0.04364950954914093,
0.005127650685608387,
0.004544265102595091,
-0.0014047306030988693,
0.0019435945432633162,
-0.03038516826927662,
0.0006098680314607918,
0.008523567579686642,
0.01864376850426197,
0.04040711373090744,
0.0165067370980978,
0.021087847650051117,
0.0007484220550395548,
-0.002545402618125081,
-0.002170807681977749,
-0.005376357119530439,
0.00012982243788428605,
-0.0001774144038790837,
-0.02275817096233368,
-0.058854375034570694,
-0.01637163572013378,
0.010936941020190716,
0.012760788202285767,
-0.013645077124238014,
-0.0013164551928639412,
0.016850626096129417,
-0.0008681695908308029,
-0.01518030185252428,
0.0035985668655484915,
0.004123613703995943,
-0.0008612610981799662,
-0.014517084695398808,
-0.0007100414368323982,
-0.043035417795181274,
0.014517084695398808,
0.013325750827789307,
-0.003518735058605671,
0.024539031088352203,
0.030581677332520485,
0.011323818005621433,
0.025668958202004433,
0.016703244298696518,
-0.01376789528876543,
0.011704552918672562,
0.011851934716105461,
-0.05610325187444687,
0.00459032179787755,
0.0007741370936855674,
0.0003972394042648375,
-0.0024486833717674017,
-0.0316624753177166,
-0.0035924259573221207,
-0.009094671346247196,
-0.029058733955025673,
-0.0036569053772836924,
-0.0014423435786738992,
-0.015904927626252174,
-0.004826746415346861,
0.01376789528876543,
0.011551030911505222,
0.007510319352149963,
-0.002662079641595483,
0.025521576404571533,
0.007418205961585045,
0.028862224891781807,
0.00727696530520916,
-0.002008073963224888,
-0.036501504480838776,
0.014431112445890903,
-0.004903507884591818,
-0.028002498671412468,
-0.03686995804309845,
0.014308294281363487,
0.02078080177307129,
0.0013011029222980142,
0.04925001040101051,
0.009088530205190182,
0.029623696580529213,
-0.01482412964105606,
-0.015757545828819275,
-0.002249104203656316,
0.00346039654687047,
0.013252059929072857,
0.019147323444485664,
0.03635412082076073,
-0.004900437314063311,
0.004105190746486187,
-0.02387581579387188,
0.014394267462193966,
-0.03163791075348854,
-0.013902994804084301,
-0.0043938132002949715,
0.02682344615459442,
-0.05458030849695206,
-0.016199691221117973,
0.013546822592616081,
0.0009288109722547233,
-0.009972820058465004,
0.0044920677319169044,
-0.017133107408881187,
0.003346789861097932,
-0.04364950954914093,
0.011311535723507404,
-0.010390400886535645,
0.020719392225146294,
0.018422696739435196,
0.0002719266922213137,
0.04050536826252937,
-0.0033529307693243027,
0.025963719934225082,
0.022573944181203842,
0.012447602115571499,
0.00035540451062843204,
-0.01626110076904297,
0.010328992269933224,
0.010599191300570965,
-0.027928808704018593,
0.005520667880773544,
0.03451185300946236,
-0.016469890251755714,
-0.04234763979911804,
0.04956933483481407,
0.016445327550172806,
-0.008775344118475914,
-0.04394427314400673,
-0.024072322994470596,
-0.0020464544650167227,
-0.018017398193478584,
-0.006490929983556271,
-0.0025285151787102222,
0.002499345922842622,
-0.003924034535884857,
0.017612097784876823,
-0.01526627503335476,
0.004313981626182795,
-0.015376810915768147,
-0.020240401849150658,
0.004476715344935656,
0.006791834253817797,
-0.04141422361135483,
-0.08793767541646957,
0.005161425564438105,
0.05271347612142563,
-0.01961403153836727,
-0.01023073773831129,
-0.031171202659606934,
0.024465341120958328,
0.03940000757575035,
-0.060524698346853256,
-0.017624380066990852,
0.02036322094500065,
0.0006359668332152069,
-0.02274588868021965,
0.004163529258221388,
0.007596292067319155,
0.044558361172676086,
-0.0216282457113266,
-0.02657780982553959,
-0.009708761237561703,
0.009266616776585579,
0.023372260853648186,
-0.0020111443009227514,
0.02827269770205021,
0.04256870970129967,
-0.004501278977841139,
0.003121111774817109,
0.010973786003887653,
-0.0008973388466984034,
0.029009606689214706,
-0.016420762985944748,
0.015082047320902348,
-0.005916756112128496,
-0.00797702744603157,
-0.005588218104094267,
-0.0073752193711698055,
-0.0031656334176659584,
0.023937223479151726,
0.01595405489206314,
0.012134416028857231,
-0.00423414958640933,
-0.014750438742339611,
-0.009843860752880573,
0.010973786003887653,
0.01462762150913477,
-0.03969477117061615,
-0.009487688541412354,
0.023630179464817047,
-0.01532768364995718,
-0.002097117016091943,
-0.0127116609364748,
0.002771080704405904,
-0.020412348210811615,
0.0014024277916178107,
0.016887471079826355,
0.003549439599737525,
0.02090361900627613,
0.02286870777606964,
0.02006845735013485,
-0.01710854470729828,
0.009506111033260822,
-0.015892647206783295,
-0.029893895611166954,
-0.0032331831753253937,
-0.025042586028575897,
-0.019540339708328247,
0.013104678131639957,
-0.016998007893562317,
-0.018545513972640038,
-0.0013233637437224388,
0.013608232140541077,
0.004722351208329201,
-0.019417522475123405,
0.02247568964958191,
-0.030262349173426628,
0.03917893394827843,
-0.01751384325325489,
0.024367086589336395,
-0.025091713294386864,
-0.022487971931695938,
-0.012257234193384647,
-0.0013509977143257856,
-0.011919484473764896,
0.03217830881476402,
-0.05949302762746811,
-0.01540137454867363,
0.042175695300102234,
0.0033375786151736975,
0.005075452849268913,
0.028223570436239243,
0.0039946548640728,
0.004280206747353077,
-0.04730948433279991,
-0.0022352871019393206,
-0.02105100080370903,
0.016064591705799103,
-0.006361971143633127,
-0.01397668570280075,
0.006260646507143974,
-0.004062204621732235,
0.014946947805583477,
-0.017010290175676346,
0.01607687398791313,
0.019012222066521645,
-0.01017546933144331,
-0.0027326999697834253,
-0.04551634192466736,
0.015020638704299927,
0.002453288994729519,
0.0188034325838089,
-0.017882296815514565,
0.008112127892673016,
-0.011772103607654572,
0.020989593118429184,
0.022561661899089813,
0.03318541869521141,
-0.024919766932725906,
-0.00966577511280775,
0.015732983127236366,
0.0037613005843013525,
-0.03109751269221306,
0.010998349636793137,
0.0460813045501709,
-0.015585601329803467,
0.005686472170054913,
-0.0029814064037054777,
0.011876498349010944,
-0.020793084055185318,
-0.0032792401034384966,
-0.019847385585308075,
-0.031171202659606934,
0.021824754774570465,
-0.02670062892138958,
0.034413598477840424,
-0.012472165748476982,
0.0009157615713775158,
0.004912719130516052,
0.012232670560479164,
-0.05003604292869568,
0.014504803344607353,
-0.01004036981612444,
-0.02006845735013485,
0.035813722759485245,
0.001291891559958458,
-0.016310228034853935,
0.016433045268058777,
0.0000348543981090188,
0.005922896787524223,
0.024342523887753487,
0.01284676045179367,
-0.0026989250909537077,
0.013104678131639957,
-0.01866833306849003,
-0.0017087050946429372,
-0.007952463813126087,
0.011256267316639423,
-0.00558514753356576,
0.02149314619600773,
0.023986350744962692,
0.0057202475145459175,
0.00848058145493269,
0.01623653620481491,
-0.011759821325540543,
-0.004406095016747713,
-0.027486663311719894,
0.01378017757087946,
-0.01622425578534603,
0.019700003787875175,
0.11878954619169235,
0.002938420046120882,
0.026086539030075073,
0.024465341120958328,
0.01483641192317009,
0.013313468545675278,
0.03153965622186661,
0.012625687755644321,
0.021272074431180954,
-0.004200374707579613,
0.03279240056872368,
0.009033262729644775,
-0.001840734388679266,
0.04234763979911804,
0.046548012644052505,
-0.013116960413753986,
0.015720700845122337,
0.01051321905106306,
-0.020584292709827423,
0.013595949858427048,
-0.018250752240419388,
0.007872632704675198,
-0.023224879056215286,
0.025374194607138634,
0.012576560489833355,
0.008265649899840355,
-0.00047131397877819836,
-0.030974693596363068,
-0.006607607007026672,
-0.030016714707016945,
0.0011391367297619581,
0.009794733487069607,
0.018594641238451004,
-0.028321824967861176,
0.017857734113931656,
-0.021259792149066925,
-0.022144081071019173,
-0.02955000475049019,
0.028862224891781807,
-0.011010631918907166,
0.0019589466974139214,
-0.005357934162020683,
0.016862908378243446,
0.012521293014287949,
0.008142831735312939,
0.004928071517497301,
-0.006257575936615467,
0.009905270300805569,
0.015622447244822979,
-0.009555238299071789,
-0.0012527434155344963,
-0.012343206442892551,
0.018336724489927292,
0.010758854448795319,
-0.00684710219502449,
-0.012066866271197796,
-0.028051625937223434,
-0.0001682030560914427,
-0.013448568992316723,
-0.03659975901246071,
-0.014013531617820263,
0.0007330697844736278,
0.026233920827507973,
-0.008677090518176556,
0.023359978571534157
] | 2025-01-11 | 82 | 39794936 | [
"mouse tumor cell lines",
"T cell receptor",
"tumor control",
"tumors",
"TCR",
"coengineered TCR-T cells",
"DMβ-T cell transfer",
"human β2",
"A2Kb",
"human TCRs",
"B16 melanoma",
"DMβ-T cells",
"NY",
"HLA",
"ACT studies",
"a near non-binding TCR",
"(TCR)-engineered T cells",
"GS linkers",
"ACT",
"the control TCR-T cells",
"The adoptive cell transfer",
"murine",
"B16",
"combination treatments",
"our chimeric syngeneic tumor model",
"A2",
"strategies",
"superior infiltration",
"both primary human and murine T cells",
"a supraphysiological affinity A2/NY TCR"
] | [
"Adoptive cell therapy - ACT",
"Immunotherapy",
"T cell",
"T cell Receptor - TCR",
"Tumor microenvironment - TME"
] | 0 | 10.1136/jitc-2024-009504
10.1038/s41586-018-0130-2
10.1038/s41586-021-03704-y
10.1126/science.aak9510
10.1038/s41587-021-01072-6
10.1056/NEJM198812223192527
10.1158/1078-0432.CCR-11-0116
10.1093/annonc/mdz398
10.1158/1078-0432.CCR-13-0380
10.1038/s41591-018-0040-8
10.1038/s41591-021-01462-y
10.1126/science.1251102
10.1158/1078-0432.CCR-18-0573
10.1200/JCO.2014.58.9093
10.1038/d41573-023-00206-6
10.1016/j.ccell.2018.03.012
10.1002/eji.201242606
10.1038/s41573-023-00809-z
10.1016/S0140-6736(24)00319-2
10.1038/d41573-024-00134-z
10.1038/s41551-023-01013-5
10.1038/s41551-019-0409-0
10.1056/NEJMoa2300709
10.1016/j.tibs.2017.11.008
10.1126/science.abp8933
10.1111/imr.13252
10.1002/ijc.1282
10.1002/jmr.1005
10.1084/jem.20042323
10.1074/jbc.M112.357673
10.4049/jimmunol.1000173
10.1038/s41467-023-38946-z
10.1002/ijc.34453
10.1158/2159-8290.CD-21-0003
10.1093/annonc/mdx238
10.1084/jem.20192203
10.1038/s41590-023-01477-2
10.1158/0008-5472.CAN-06-1450
10.1110/ps.051936406
10.1038/375148a0
10.1084/jem.173.4.1007
10.1034/j.1600-065x.2002.18808.x
10.1002/eji.200737923
10.1084/jem.189.6.895
10.4049/jimmunol.168.7.3145
10.1074/jbc.M303716200
10.1074/jbc.M709935200
10.1038/s41590-017-0004-z
10.1038/mtm.2014.27
10.1038/nature14001
10.3389/fimmu.2023.1102282
10.1172/JCI65325
10.1038/s41571-023-00754-1
10.1016/s1074-7613(00)80483-5
10.1172/JCI161660
10.1200/JCO.18.02424
10.1038/s41591-020-01225-1
10.1158/2159-8290.CD-17-1417
10.1038/s44318-024-00235-w
10.3389/fimmu.2022.976628
10.1101/2023.05.24.541283
10.1182/blood-2001-12-0207
10.18632/oncotarget.7044
10.1038/s41467-017-00786-z
10.1038/s41591-018-0036-4
10.1038/nbt.2858
10.1073/pnas.1019682108
10.1182/blood-2010-08-301507
10.1182/blood-2010-10-310425
10.1084/jem.20201966
10.1089/ars.2010.3694
10.1002/cpbi.3
10.1093/nar/gkw1000
10.1093/nar/gkh340
10.1002/jcc.20084
10.1038/s41590-020-0676-7 | [
"Semilietof",
"Stefanidis",
"Gray-Gaillard",
"Pujol",
"D'Esposito",
"Reichenbach",
"Guillaume",
"Zoete",
"Irving",
"Michielin"
] | [
"Swiss Institute of Bioinformatics, Lausanne, Switzerland.\nDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland.",
"Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland.",
"Swiss Institute of Bioinformatics, Lausanne, Switzerland.\nDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland.",
"Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland.",
"Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland.",
"Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland.",
"Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland.",
"Swiss Institute of Bioinformatics, Lausanne, Switzerland [email protected] [email protected] [email protected].\nDepartment of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland.",
"Department of Oncology, Ludwig Institute for Cancer Research Lausanne, University of Lausanne, Epalinges, Switzerland [email protected] [email protected] [email protected].",
"Swiss Institute of Bioinformatics, Lausanne, Switzerland [email protected] [email protected] [email protected].\nPrecision Oncology, University Hospital of Geneva, Geneva, Switzerland."
] | [
"39794936",
"29769722",
"34290406",
"28408606",
"34782741",
"3264384",
"21498393",
"31566658",
"23690483",
"29867227",
"34385708",
"24812403",
"29853601",
"25823737",
"38093023",
"29634943",
"22949370",
"37891435",
"38554725",
"39152243",
"37069267",
"31182835",
"37314354",
"29269020",
"37228189",
"37548063",
"22388761",
"14522938",
"9050879",
"11351307",
"36075914",
"24062738",
"20151417",
"15837811",
"22549784",
"20351194",
"37280206",
"36727538",
"34479871",
"29045511",
"33156338",
"37081150",
"16951205",
"16600963",
"7753171",
"1706750",
"10092815",
"12445283",
"18546142",
"10075973",
"16424053",
"11907065",
"12732632",
"18195006",
"29180808",
"26015969",
"25428506",
"36969213",
"23391724",
"37055515",
"8673703",
"38828721",
"31408414",
"33558725",
"29891538",
"39284912",
"36203587",
"12384415",
"26824989",
"28955032",
"29808007",
"24633240",
"21262803",
"21252091",
"21385853",
"34935874",
"21126187",
"27322406",
"27794042",
"15034147",
"15264254",
"32424363"
] | [] | 9.368359 | 4.713792 |
39794934 | 45 | Neuropsychiatric manifestations following chimeric antigen receptor T cell therapy for cancer: a systematic review of clinical outcomes and management strategies. | Chimeric antigen receptor (CAR)-T cell therapy has emerged as a transformative modality in the treatment of patients with cancer. However, it is increasingly evident that this therapeutic approach is not without its challenges. The unique nature of CAR-T cells as living drugs introduces a distinct set of side effects. As the application of CAR-T cell therapy expands to treat a broader range of diseases, it becomes increasingly important to devise effective strategies for handling the associated toxicities. Challenges in treating patients with CAR-T cells include addressing complications such as cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, and cytopenias. This comprehensive review seeks to systematically identify, categorize and elucidate all previously described neurological and psychological side effects associated with CAR-T cell therapy, shedding light on the pertinent laboratory findings that underscore these phenomena.
PubMed, Springer Link, and ScienceDirect were systematically searched for empirical studies on adult patients with cancer receiving CAR-T cell therapy for hemato-oncological malignancies. Quality assessment was conducted using Version 2 of the Cochrane risk-of-bias tool (RoB 2) for randomized trials and adherence to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) checklist for observational studies. The synthesis of findings was conducted via a narrative approach, consolidating the diverse array of data into a coherent framework.
From an initial pool of 2,276 citations, 546 studies met the inclusion criteria, exhibiting a rich tapestry of heterogeneity in terms of study characteristics and patient samples. The incidence of neuropsychological symptoms varied notably across different CAR-T cell products and hematological malignancies. Among the most frequently reported neuropsychological symptoms were aphasia, attention deficits, impaired consciousness, and disorientation, alongside a constellation of other symptoms including confusion, cognitive impairment, memory loss, writing difficulties, fatigue, headache, agitation, tremor, seizures, and psychomotor retardation. Early intervention strategies, including corticosteroids and tocilizumab, have shown the potential to reduce the intensity of neuropsychological symptoms and prevent their progression to critical complications.
These insights underscore the imperative of extending neuropsychological assessments beyond the conventional Immune Effector Cell-Associated Encephalopathy score framework. | [
0.024585191160440445,
0.03014983795583248,
0.04257435351610184,
0.04271826893091202,
-0.0521925613284111,
-0.00530080683529377,
0.03995992988348007,
0.00310912705026567,
0.01192681584507227,
0.01375571358948946,
0.016334161162376404,
-0.03314803168177605,
-0.036362096667289734,
-0.011315183714032173,
-0.00030281758517958224,
-0.028015123680233955,
0.03722557798027992,
0.017269596457481384,
0.03715362027287483,
0.046555954962968826,
0.027223601937294006,
0.033627744764089584,
0.0011295696021988988,
0.006047357339411974,
-0.015602601692080498,
0.004770126659423113,
0.014583215117454529,
-0.02408149465918541,
-0.033076073974370956,
-0.027487441897392273,
0.02796715311706066,
-0.019356340169906616,
-0.025760482996702194,
-0.041734859347343445,
-0.013863649219274521,
0.029094474390149117,
0.039168406277894974,
0.00994201097637415,
-0.007261625956743956,
-0.029646141454577446,
0.05276821553707123,
0.04250239580869675,
0.005792510695755482,
0.10860657691955566,
-0.07344376295804977,
-0.019272390753030777,
0.021383119747042656,
-0.07440318167209625,
0.01524281781166792,
0.026288164779543877,
-0.03499491885304451,
0.040799424052238464,
-0.01449926570057869,
0.02681584656238556,
-0.04662791267037392,
0.030125852674245834,
-0.020987357944250107,
0.0063441782258450985,
0.0064401207491755486,
0.0048360866494476795,
0.0061642867513000965,
-0.022306563332676888,
0.007393546402454376,
-0.02456120401620865,
-0.03928833454847336,
-0.015770500525832176,
-0.04115920513868332,
-0.028734691441059113,
0.0011812883894890547,
0.0237696822732687,
0.025304757058620453,
-0.007771318778395653,
0.026552006602287292,
-0.0003279274678789079,
0.010145888663828373,
0.0014638681896030903,
0.000009105842764256522,
0.018564816564321518,
0.01020585186779499,
-0.029046503826975822,
0.026432078331708908,
-0.01722162589430809,
-0.01713767647743225,
-0.04463711008429527,
-0.022570403292775154,
0.00718966918066144,
-0.019680144265294075,
-0.04458913952112198,
-0.033867597579956055,
0.026528019458055496,
-0.02157500386238098,
0.0015530644450336695,
-0.06946215778589249,
0.0428621806204319,
-0.011471089906990528,
0.011087321676313877,
0.008586827665567398,
-0.03813702613115311,
0.02588040940463543,
0.03595434129238129,
0.05526271089911461,
0.011722938157618046,
-0.062458377331495285,
-0.0019488261314108968,
0.0678311437368393,
0.028422879055142403,
-0.041183192282915115,
-0.0026069297455251217,
0.019344346597790718,
0.005231848452240229,
0.05075342580676079,
-0.006458109710365534,
-0.020291777327656746,
0.05080140009522438,
-0.03357977420091629,
-0.06173881143331528,
-0.03048563562333584,
0.00806514173746109,
-0.0017629381036385894,
0.0467478409409523,
-0.04945820942521095,
0.011644985526800156,
0.02837490849196911,
0.015290789306163788,
-0.005945418495684862,
-0.037921156734228134,
0.06989389657974243,
-0.03295614942908287,
-0.03871268033981323,
-0.06984592974185944,
0.02736751362681389,
-0.00041187688475474715,
0.033243972808122635,
-0.020555617287755013,
-0.09052146971225739,
-0.00040850392542779446,
-0.023242000490427017,
-0.022306563332676888,
-0.021934786811470985,
-0.046316102147102356,
0.02602432295680046,
-0.03561854362487793,
-0.003561854362487793,
0.017977170646190643,
-0.03298013284802437,
-0.036577966064214706,
0.019200434908270836,
0.04168688878417015,
-0.01994398608803749,
0.054974883794784546,
-0.007381553761661053,
0.036817822605371475,
0.03655398264527321,
-0.0021392113994807005,
0.032140638679265976,
-0.033076073974370956,
0.01791720651090145,
0.07464303821325302,
-0.024801060557365417,
-0.0763220265507698,
0.011764912866055965,
-0.041255149990320206,
-0.006913835182785988,
-0.02952621504664421,
0.024657147005200386,
-0.0229781586676836,
-0.0015163365751504898,
0.025304757058620453,
-0.034491222351789474,
-0.04279022291302681,
0.0009107014047913253,
-0.06476099044084549,
-0.07819289714097977,
-0.02820700965821743,
-0.051712848246097565,
-0.008694762364029884,
0.0011835370678454638,
0.023589789867401123,
-0.009456303901970387,
-0.008035159669816494,
0.004413341637700796,
0.004011583514511585,
0.011363155208528042,
0.022714316844940186,
-0.044924937188625336,
-0.0038556773215532303,
-0.03190078213810921,
0.01941630430519581,
-0.05137705057859421,
-0.012952198274433613,
0.018756700679659843,
-0.032212596386671066,
0.030293751507997513,
-0.006404142361134291,
-0.011860854923725128,
-0.007561445236206055,
0.026384107768535614,
0.0358344130218029,
-0.04202268645167351,
-0.030725492164492607,
0.034083470702171326,
0.00455725472420454,
-0.028782662004232407,
0.0034629139117896557,
-0.0008837176719680429,
-0.03343585878610611,
-0.016957785934209824,
0.03684180602431297,
-0.005414738319814205,
0.00508493697270751,
0.026456063613295555,
0.0056426008231937885,
-0.01204674318432808,
0.05324792489409447,
-0.028662733733654022,
-0.025304757058620453,
-0.029718099161982536,
0.04857074096798897,
0.01472712866961956,
0.005132908001542091,
-0.00576552702113986,
-0.014703143388032913,
0.000842492503579706,
-0.0012937206774950027,
-0.015650572255253792,
0.008161083795130253,
0.011722938157618046,
0.0021107285283505917,
0.010691559873521328,
-0.05152096599340439,
-0.009096520021557808,
-0.006392149720340967,
0.03734550252556801,
-0.015398724004626274,
-0.02681584656238556,
-0.016861842945218086,
0.05118516832590103,
0.02931034378707409,
0.04715559631586075,
-0.015770500525832176,
0.04768327623605728,
0.011908826418220997,
-0.0011205750051885843,
-0.04233449697494507,
-0.02549664117395878,
-0.012844262644648552,
-0.008610812947154045,
-0.08193464577198029,
0.020519640296697617,
-0.007021770346909761,
0.012820277363061905,
0.00794521439820528,
0.018037134781479836,
0.0028947563841938972,
0.01926039718091488,
-0.022630367428064346,
0.055598508566617966,
-0.060587503015995026,
0.0010118904756382108,
-0.0057235523127019405,
0.047275520861148834,
-0.02564055472612381,
-0.03254839405417442,
-0.054111406207084656,
-0.040727466344833374,
0.015566622838377953,
0.014715136028826237,
0.003696773201227188,
0.0002046267327386886,
-0.00907853152602911,
0.049362264573574066,
0.014883034862577915,
0.02588040940463543,
0.0021002348512411118,
-0.05914837121963501,
0.0233859121799469,
0.012052739970386028,
0.0397680439054966,
-0.010547646321356297,
0.0307734627276659,
-0.006757928989827633,
0.007369560655206442,
-0.011267213150858879,
-0.050225745886564255,
-0.013995569199323654,
0.0013034648727625608,
0.00139790796674788,
-0.006739940028637648,
-0.018588801845908165,
-0.027007730677723885,
-0.002885761670768261,
-0.00802316702902317,
-0.008310993202030659,
-0.03391557186841965,
-0.0029352318961173296,
-0.016238218173384666,
0.003139109117910266,
-0.00794521439820528,
-0.05603024736046791,
-0.013827670365571976,
-0.045476604253053665,
0.016346152871847153,
-0.021766887977719307,
-0.03967210277915001,
0.04698769748210907,
-0.00069895398337394,
-0.020075906068086624,
-0.019908007234334946,
0.015878435224294662,
0.024585191160440445,
0.01363578625023365,
-0.026432078331708908,
0.05027371644973755,
0.011555039323866367,
-0.008868657983839512,
0.026528019458055496,
0.04888255521655083,
-0.03278825059533119,
0.041806817054748535,
-0.039792031049728394,
-0.030989332124590874,
0.002473510103300214,
-0.02619222179055214,
0.028183022513985634,
0.03998391330242157,
-0.03530673310160637,
-0.0026384107768535614,
0.02432134933769703,
0.0428381972014904,
-0.024249393492937088,
0.004017579834908247,
-0.0229781586676836,
0.05276821553707123,
0.001753943506628275,
0.02400953695178032,
-0.04036768525838852,
-0.025520626455545425,
-0.03638608008623123,
0.018720723688602448,
-0.008281012065708637,
-0.029598170891404152,
0.02650403417646885,
-0.04456515610218048,
0.047875162214040756,
-0.027535412460565567,
-0.04653197154402733,
-0.013683756813406944,
0.000458348891697824,
0.01720963418483734,
0.03295614942908287,
-0.02057960256934166,
0.0039935945533216,
0.010379747487604618,
0.02167094685137272,
-0.026288164779543877,
0.03055759333074093,
-0.043989501893520355,
0.013060132972896099,
0.0020342746283859015,
0.009096520021557808,
0.028302950784564018,
-0.005333786830306053,
-0.023577798157930374,
0.07982391864061356,
0.06303402781486511,
0.04979400709271431,
-0.03202071040868759,
0.06452113389968872,
-0.055838365107774734,
-0.050465602427721024,
0.006047357339411974,
-0.014331366866827011,
0.03178085759282112,
-0.013791692443192005,
-0.052720241248607635,
0.04926632344722748,
0.007921228185296059,
0.01714967004954815,
0.02205471508204937,
0.001974310725927353,
0.028878604993224144,
-0.010229838080704212,
-0.018181048333644867,
-0.017341554164886475,
-0.0016400121385231614,
0.0253287423402071,
0.02423739992082119,
0.0016250211047008634,
-0.07536260038614273,
0.02782323956489563,
-0.02875867672264576,
-0.027103673666715622,
-0.016178254038095474,
0.0005842730752192438,
-0.008316989988088608,
0.0856763944029808,
-0.052720241248607635,
0.07900840789079666,
0.07368361204862595,
-0.015446695499122143,
0.030341722071170807,
-0.0048121013678610325,
-0.006847875192761421,
-0.023110078647732735,
0.017341554164886475,
0.002101734047755599,
0.05017777532339096,
0.0013147080317139626,
0.024609176442027092,
-0.028494834899902344,
0.04077543690800667,
-0.018960578367114067,
0.019584203138947487,
0.023589789867401123,
0.006041361019015312,
-0.057469382882118225,
-0.04324594885110855,
0.059963878244161606,
-0.00868276972323656,
0.07022969424724579,
0.03950420394539833,
-0.028254980221390724,
-0.01792920008301735,
0.0001988177391467616,
-0.012868248857557774,
0.014823070727288723,
-0.00207325117662549,
-0.023194028064608574,
0.03703369200229645,
-0.023397905752062798,
-0.03024578094482422,
0.05713358521461487,
-0.009216448292136192,
0.017869235947728157,
0.01627419702708721,
0.015914414077997208,
-0.026743890717625618,
0.036745864897966385,
-0.04708363860845566,
0.006458109710365534,
-0.04792313277721405,
0.010811487212777138,
-0.002644407097250223,
0.02174290269613266,
0.05780518054962158,
-0.027607370167970657,
-0.002112227724865079,
0.009144491516053677,
-0.013240024447441101,
-0.030653534457087517,
-0.018181048333644867,
-0.00046659394865855575,
0.002545466646552086,
-0.02237851917743683,
-0.040079858154058456,
-0.002782324096187949,
0.027847224846482277,
-0.06380156427621841,
0.03569050133228302,
0.02245047688484192,
0.03403549641370773,
-0.032068680971860886,
0.0005636604619212449,
-0.003435930237174034,
0.02204272150993347,
0.02751142717897892,
0.004608224146068096,
-0.01886463724076748,
-0.02089141495525837,
-0.006829885765910149,
0.0008050150936469436,
0.025544611737132072,
-0.017521444708108902,
-0.01954822428524494,
0.005843480117619038,
0.011716942302882671,
0.008940614759922028,
0.016070319339632988,
0.02002793550491333,
0.0036727876868098974,
-0.021167248487472534,
-0.018037134781479836,
-0.0034779049456119537,
0.023793667554855347,
0.03964811563491821,
0.028926575556397438,
0.002675888128578663,
0.011189259588718414,
-0.028974546119570732,
0.06053953245282173,
-0.03333991765975952,
-0.017821265384554863,
0.04715559631586075,
-0.011525057256221771,
-0.020375726744532585,
0.001390412449836731,
-0.00442533427849412,
-0.008328982628881931,
0.005936424247920513,
-0.013192053884267807,
0.012640385888516903,
0.020711524412035942,
-0.014055533334612846,
0.028638748452067375,
0.0038646720349788666,
0.06212257966399193,
0.0069558098912239075,
0.06327388435602188,
-0.0019443287746980786,
0.015590609051287174,
-0.023206021636724472,
-0.021874822676181793,
0.05962808057665825,
0.0012487478088587523,
-0.021958772093057632,
-0.023733703419566154,
-0.04511682316660881,
-0.03569050133228302,
-0.001945827854797244,
-0.0022516436874866486,
-0.01666995882987976,
-0.025064902380108833,
-0.008251029998064041,
0.01033177599310875,
0.02540070004761219,
-0.028926575556397438,
-0.03468310832977295,
-0.016789887100458145,
-0.014403323642909527,
-0.03298013284802437,
0.02134714089334011,
-0.004398350603878498,
-0.0021676942706108093,
-0.00149010238237679,
-0.037681300193071365,
-0.009894040413200855,
-0.03216462582349777,
0.0118788443505764,
-0.029742084443569183,
-0.018744708970189095,
0.00939034391194582,
-0.016154268756508827,
0.037825215607881546,
-0.03302810341119766,
-0.008514870889484882,
-0.01689782179892063,
0.007219651248306036,
-0.02409348636865616,
0.005486695095896721,
-0.027847224846482277,
0.00013210791803430766,
-0.031133245676755905,
0.030029911547899246,
0.012916219420731068,
0.022018736228346825,
-0.006113317329436541,
-0.01469115074723959,
-0.04326993599534035,
0.0047971103340387344,
-0.03062954917550087,
0.0025184829719364643,
-0.03134911507368088,
0.003459915751591325,
-0.01320404652506113,
-0.03926434740424156,
0.019188441336154938,
0.020315762609243393,
-0.032932162284851074,
-0.011387140490114689,
0.026528019458055496,
-0.03600231185555458,
-0.017161661759018898,
0.016741914674639702,
-0.0037507405504584312,
0.04163891822099686,
-0.006260228808969259,
-0.009372354485094547,
-0.008754726499319077,
-0.009750126861035824,
0.013827670365571976,
-0.004635207820683718,
-0.011603010818362236,
-0.005333786830306053,
0.05511879920959473,
-0.018972571939229965,
0.04693972319364548,
-0.03921637684106827,
-0.011357158422470093,
-0.0027148646768182516,
-0.0005501685664057732,
0.04027174040675163,
-0.001059861620888114,
0.0206635519862175,
-0.0007960204966366291,
-0.028254980221390724,
0.01567455753684044,
0.041279133409261703,
-0.025376712903380394,
-0.012604407034814358,
0.024129465222358704,
-0.018960578367114067,
-0.02588040940463543,
-0.000942182436119765,
-0.02345786988735199,
-0.014535244554281235,
0.030293751507997513,
0.009672173298895359,
-0.016705937683582306,
0.011423119343817234,
0.02945425733923912,
0.041734859347343445,
0.03185281157493591,
-0.02719961479306221,
0.021467069163918495,
0.012412522919476032,
0.006398146040737629,
-0.020051920786499977,
-0.021179242059588432,
0.017749307677149773,
0.004518278408795595,
-0.01301216147840023,
0.01971612311899662,
0.005231848452240229,
-0.0074774958193302155,
0.012424515560269356,
-0.03482702001929283,
-0.009960000403225422,
-0.0009211950819008052,
0.005459711421281099,
-0.01604633405804634,
-0.017161661759018898,
-0.013851655647158623,
-0.018804673105478287,
0.011039350181818008,
-0.011507068760693073,
0.009294400922954082,
0.01917644776403904,
-0.02237851917743683,
-0.0041345092467963696,
-0.007789307739585638,
-0.011339169926941395,
-0.004764130339026451,
0.0006487342179752886,
-0.010073931887745857,
-0.0032350511755794287,
-0.028087081387639046,
-0.028494834899902344,
-0.0012757314834743738,
0.014547237195074558,
0.007849271409213543,
0.01008592452853918,
-0.01472712866961956,
0.018097098916769028,
-0.010457700118422508,
0.011081324890255928,
-0.02976606972515583,
-0.00368178216740489,
0.0022261589765548706,
0.04540465027093887,
0.08227044343948364,
-0.013252017088234425,
0.008694762364029884,
-0.024021530523896217,
-0.0005509181646630168,
0.01714967004954815,
0.018924599513411522,
0.017101697623729706,
-0.015446695499122143,
0.0035138833336532116,
0.004953016526997089,
0.0521925613284111,
0.018888622522354126,
0.0017599398270249367,
-0.010415725409984589,
0.024825045838952065,
-0.002509488258510828,
0.02409348636865616,
-0.021155256778001785,
-0.005147899035364389,
0.028710706159472466,
-0.033555787056684494,
0.0037447442300617695,
-0.02269033156335354,
-0.07070940732955933,
0.004605225753039122,
-0.008976592682301998,
0.021874822676181793,
0.004269428085535765,
0.0358344130218029,
0.001047119265422225,
0.011644985526800156,
-0.02633613534271717,
-0.044781025499105453,
0.013419915921986103,
0.005534666124731302,
0.02306210808455944,
-0.01893659308552742,
-0.007303600665181875,
0.0058944495394825935,
-0.034563180059194565,
0.024417292326688766,
0.0280630961060524,
0.039000507444143295,
-0.022618375718593597,
0.017041735351085663,
-0.0307734627276659,
-0.004494292661547661,
-0.03022179566323757,
0.03468310832977295,
0.022786274552345276,
-0.02494497410953045,
-0.008382949978113174,
-0.01535075344145298,
-0.004863070789724588,
-0.03696173429489136,
0.0015830463962629437,
-0.01274832058697939,
0.039624132215976715,
0.02657599188387394,
0.0042154607363045216,
-0.006584033835679293,
0.031157230958342552,
-0.02213866449892521,
0.0008417429635301232,
0.014487273059785366,
0.0070457556284964085,
-0.020531632006168365,
0.044229358434677124,
0.0007802799809724092,
-0.007909235544502735,
0.015110897831618786,
-0.02695976011455059,
-0.010943408124148846,
-0.018900614231824875,
-0.004419337958097458,
0.030341722071170807,
-0.008934617973864079,
-0.03314803168177605,
-0.012928212061524391,
-0.007249632850289345,
0.02198275737464428,
-0.027295557782053947,
-0.0335078164935112,
0.01777329295873642,
0.0014856051420792937,
0.019524239003658295,
0.009678170084953308,
0.017893221229314804,
-0.00942632183432579,
-0.03477904945611954,
0.010079927742481232,
0.008568838238716125,
-0.02619222179055214,
-0.01932036131620407,
0.006434124428778887,
-0.024345334619283676,
-0.011974786408245564,
-0.0002409798325970769,
-0.0022906202357262373,
-0.01394759863615036,
-0.009714148007333279,
0.006871860474348068,
-0.0307734627276659,
0.00802916381508112,
-0.004497291054576635,
-0.008934617973864079,
0.0335078164935112,
0.0218148585408926,
-0.011764912866055965,
0.00885066855698824,
-0.0198840219527483,
-0.020303769037127495,
0.009834076277911663,
-0.0061642867513000965,
-0.017161661759018898,
0.008586827665567398,
-0.04039166867733002,
0.01707771234214306,
0.004323395900428295,
-0.010667573660612106,
-0.01025382336229086,
0.0019937988836318254,
-0.014655171893537045,
0.019979964941740036,
-0.006452113389968872,
-0.016933798789978027,
-0.02095137909054756,
0.001093591214157641,
-0.010307790711522102,
-0.010541649535298347,
-0.0237696822732687,
0.030893390998244286,
-0.0041764844208955765,
0.005924431141465902,
-0.02626417949795723,
0.016705937683582306,
0.022930188104510307,
-0.08745132386684418,
0.00489005446434021,
0.0029412282165139914,
-0.007873257622122765,
0.009336375631392002,
0.004023576155304909,
-0.04463711008429527,
0.01876869425177574,
0.023877616971731186,
-0.020375726744532585,
0.022018736228346825,
-0.009522263891994953,
-0.007951210252940655,
-0.0148110780864954,
-0.006560048554092646,
-0.012244624085724354,
0.0017704335041344166,
-0.04576443135738373,
0.007801300846040249,
0.026935774832963943,
0.006110319402068853,
0.019931994378566742,
-0.021622974425554276,
0.07214853912591934,
-0.0005872712354175746,
0.019596194848418236,
-0.01567455753684044,
-0.04101529344916344,
-0.03302810341119766,
-0.014547237195074558,
-0.011662974953651428,
0.012364552356302738,
-0.024992944672703743,
0.021491054445505142,
-0.010019964538514614,
-0.03950420394539833,
0.014271403662860394,
-0.02578446827828884,
-0.04245442524552345,
0.010727537795901299,
0.011501071974635124,
0.03967210277915001,
0.04348580539226532,
0.0026234197430312634,
0.003666791133582592,
0.0012742324033752084,
-0.03420339524745941,
0.0023520831018686295,
0.010367754846811295,
0.0026024323888123035,
0.02463316172361374,
-0.015530644915997982,
-0.01830097660422325,
-0.025760482996702194,
-0.0167539082467556,
-0.008982589468359947,
0.0037447442300617695,
0.014871042221784592,
0.014343359507620335,
0.022486453875899315,
0.008119109086692333,
0.0490984246134758,
0.034179411828517914,
-0.0237576887011528,
-0.011483082547783852,
-0.00814909115433693,
-0.05636604502797127,
0.01043971162289381,
-0.01970413140952587,
0.021994750946760178,
-0.018133077770471573,
-0.002274130005389452,
-0.03372368589043617,
0.00018148442904930562,
-0.021491054445505142,
-0.0020042925607413054,
0.014319374226033688,
-0.014859049580991268,
-0.0010156382340937853,
0.018312968313694,
-0.0024750090669840574,
-0.04643602669239044,
-0.020327754318714142,
0.017029741778969765,
-0.004218459129333496,
0.011267213150858879,
0.003214063821360469,
0.02743947133421898,
0.015866441652178764,
-0.005024973303079605,
-0.010265816003084183,
-0.002788320416584611,
0.023625768721103668,
0.014103504829108715,
0.006422131322324276,
-0.01021184865385294,
-0.03722557798027992,
0.0167539082467556,
-0.002056760946288705,
-0.021407105028629303,
0.024501241743564606,
-0.0350668765604496,
0.026839831843972206,
-0.014103504829108715,
-0.014271403662860394,
0.005768525414168835,
0.020999349653720856,
0.008352968841791153,
0.001815406489185989,
-0.0003369220357853919,
-0.0054627093486487865,
-0.03895253688097,
0.03537868708372116,
-0.011453100480139256,
-0.008011174388229847,
-0.01791720651090145,
0.017185647040605545,
-0.011549043469130993,
0.01768934354186058,
-0.0007428025710396469,
0.07042157649993896,
0.018061120063066483,
-0.0083769541233778,
-0.005624611862003803,
-0.020123878493905067,
-0.009708152152597904,
0.0024510235525667667,
-0.013731728307902813,
-0.008838675916194916,
0.0074774958193302155,
0.02191080152988434,
-0.0019937988836318254,
0.013120097108185291,
0.0002739599731285125,
-0.015410716645419598,
0.04425334185361862,
0.0335317999124527,
-0.005192872136831284,
0.04482899606227875,
0.018133077770471573,
-0.009336375631392002,
-0.0053727636113762856,
0.0028542806394398212,
-0.028087081387639046,
0.04029572755098343,
-0.027487441897392273,
-0.02969411388039589,
0.025928381830453873,
0.013048140332102776,
0.016070319339632988,
-0.030821433290839195,
0.004860072396695614,
0.030677519738674164,
0.052240531891584396,
0.016262203454971313,
0.02158699743449688,
0.012568429112434387,
-0.009558242745697498,
-0.05252835899591446,
-0.009138495661318302,
-0.03871268033981323,
0.04821095988154411,
-0.02859077788889408,
-0.017821265384554863,
0.014283396303653717,
-0.019188441336154938,
-0.025928381830453873,
-0.013731728307902813,
0.03453919291496277,
0.015182854607701302,
0.009180470369756222,
-0.06111518666148186,
0.044924937188625336,
-0.00290375086478889,
-0.001984804403036833,
0.021395111456513405,
-0.0010733534581959248,
0.006679976359009743,
0.02470511756837368,
0.014427308924496174,
-0.03828094154596329,
-0.005330788902938366,
0.008484888821840286,
0.009294400922954082,
0.050609514117240906,
-0.018432896584272385,
-0.03007788211107254,
-0.042982108891010284,
-0.00467418460175395,
-0.007669379934668541,
-0.02969411388039589,
-0.019668152555823326,
-0.006200265139341354,
0.073251873254776,
0.004548260010778904,
-0.03014983795583248,
0.0018139072926715016,
-0.009720144793391228,
-0.028183022513985634,
-0.044469211250543594,
-0.04550059139728546,
0.04341384768486023,
0.04427732899785042,
-0.02993396855890751,
-0.0072556291706860065,
0.04223855584859848,
0.002654900774359703,
-0.034635137766599655,
0.02384163811802864,
0.013767706230282784,
-0.007729344069957733,
0.06495287269353867,
-0.030509620904922485,
0.037921156734228134,
-0.007993184961378574,
0.026168236508965492,
0.026623962447047234,
-0.005351776257157326,
-0.047899145632982254,
-0.005066948011517525,
-0.05003385990858078,
-0.03242846578359604,
0.007609416265040636,
-0.029478242620825768,
0.005192872136831284,
-0.0008739735349081457,
0.03053360804915428,
0.022078700363636017,
0.015314774587750435,
0.0062542324885725975,
-0.002563455840572715,
0.013599807396531105,
0.014751113951206207,
0.028159037232398987,
0.019848044961690903,
-0.00814309436827898,
-0.026839831843972206,
-0.019128477200865746,
0.02049565315246582,
0.023901602253317833,
0.03984000161290169,
0.024129465222358704,
0.0009376851376146078,
-0.044373270124197006,
-0.015506659634411335,
-0.021922795102000237,
0.04168688878417015,
-0.017749307677149773,
-0.0008132600924000144,
-0.011704949662089348,
-0.018348947167396545,
0.0014166466426104307,
0.042286526411771774,
-0.0007937718764878809,
0.026671933010220528,
-0.012268609367311,
-0.005366767290979624,
0.02736751362681389,
0.004506285302340984,
0.015794485807418823,
-0.004464310593903065,
-0.00279581593349576,
-0.0335078164935112,
-0.017665358260273933,
0.03904847800731659,
-0.008658784441649914,
-0.0008379952050745487,
-0.02423739992082119,
0.010121902450919151,
0.006901842541992664,
-0.005624611862003803,
0.00582848908379674,
-0.015590609051287174,
-0.004533269442617893,
-0.01627419702708721,
-0.0175334382802248,
0.010235833935439587,
-0.001684985007159412,
-0.007069741375744343,
-0.01087145134806633,
-0.013371945358812809,
0.00467418460175395,
0.00024566453066654503,
-0.013575822114944458,
0.022570403292775154,
0.0007214404176920652,
-0.017809271812438965,
-0.03751340135931969,
-0.009294400922954082,
0.001613028347492218,
-0.031924769282341,
0.001249497290700674,
-0.019272390753030777,
-0.0105176642537117,
0.011411125771701336,
-0.02222261391580105,
0.0012757314834743738,
0.009282408282160759,
0.024801060557365417,
-0.0005033218185417354,
-0.023206021636724472,
0.018732715398073196,
0.002560457680374384,
0.0033040097914636135,
-0.006017375271767378,
-0.023014137521386147,
-0.028638748452067375,
-0.049218352884054184,
0.027631355449557304,
-0.0009436815744265914,
-0.04533269256353378,
0.02011188492178917,
0.00621825410053134,
-0.018312968313694,
0.022414498031139374,
0.01830097660422325,
-0.011087321676313877,
-0.01021184865385294,
0.017521444708108902,
0.02796715311706066,
-0.010673570446670055,
0.0065960269421339035,
-0.0034988922998309135,
-0.006116315722465515,
-0.023242000490427017,
-0.024609176442027092,
-0.00631419662386179,
-0.019428296014666557,
-0.021718917414546013,
-0.01627419702708721,
0.01118326373398304,
-0.001282477518543601,
0.002440529875457287,
-0.0007862763595767319,
0.021059313789010048,
-0.000359783269232139,
-0.005891451146453619,
-0.02664794772863388,
-0.004008585121482611,
0.00493202917277813,
-0.008436918258666992,
0.00846090354025364,
0.013623793609440327,
0.014631186611950397,
0.01839691773056984,
-0.0018378929235041142,
-0.018876628950238228,
-0.027103673666715622,
-0.008910632692277431,
-0.004548260010778904,
0.06188272312283516,
-0.010925418697297573,
-0.047179579734802246,
0.03880862146615982,
0.020687539130449295,
-0.0032950150780379772,
0.002867772476747632,
0.027223601937294006,
-0.011674967594444752,
-0.014966984279453754,
-0.022846238687634468,
0.018312968313694,
0.012904226779937744,
-0.002293618395924568,
0.01437933836132288,
0.014343359507620335,
-0.029862012714147568,
0.003969608806073666,
-0.004191474989056587,
-0.003226056694984436,
0.019764093682169914,
0.009720144793391228,
-0.010271812789142132,
-0.008586827665567398,
0.01917644776403904,
0.03521078824996948,
0.051856763660907745,
-0.004539265763014555,
-0.01052366103976965,
0.029790055006742477,
-0.0003781472041737288,
-0.026480048894882202,
-0.0024495243560522795,
-0.026288164779543877,
-0.017401518300175667,
0.0019188441801816225,
-0.02501692995429039,
-0.018504852429032326,
-0.0148110780864954,
-0.018217027187347412,
0.02081945911049843,
-0.02072351612150669,
0.007651390973478556,
-0.006083335727453232,
-0.031157230958342552,
0.007315593305975199,
-0.0011475587962195277,
0.0047071645967662334,
-0.03441926836967468,
0.0024360325187444687,
-0.0037837207783013582,
-0.017641372978687286,
0.011285201646387577,
-0.0018768694717437029,
0.006266225595027208,
0.0107095493003726,
0.010919422842562199,
0.03715362027287483,
0.03156498447060585,
0.006901842541992664,
-0.016238218173384666,
0.017977170646190643,
-0.07934420555830002,
0.00969615951180458,
-0.023625768721103668,
0.004344383254647255,
0.017809271812438965,
-0.00807113852351904,
-0.025688525289297104,
-0.002091240370646119,
0.011375147849321365,
0.009258423000574112,
-0.005867465399205685,
0.0061642867513000965,
-0.0296221561729908,
-0.002080746693536639,
0.00670396164059639,
0.023397905752062798,
-0.0163701381534338,
0.013036147691309452,
0.00300119211897254,
0.018972571939229965,
0.03257237747311592,
-0.013815677724778652,
-0.03321998938918114,
0.00648809177801013,
0.00810711644589901,
0.006005382630974054,
-0.01580647937953472,
0.007549452595412731,
-0.004164491314440966,
-0.011585021391510963,
0.049841977655887604,
0.034107454121112823,
0.0010606111027300358,
-0.0023685733322054148,
0.01583046466112137,
-0.02703171595931053,
0.04403747245669365,
0.014559229835867882,
0.03031773678958416,
0.029718099161982536,
-0.007375556975603104,
-0.021922795102000237,
-0.006458109710365534,
-0.026983745396137238,
-0.017557423561811447,
-0.004671186208724976,
0.012496472336351871,
0.02212667092680931,
-0.0002844536502379924,
-0.003471908625215292,
-0.009414329193532467,
0.003208067500963807,
-0.006524070166051388,
-0.014019555412232876,
-0.008718747645616531,
-0.03000592440366745,
-0.022858230397105217,
-0.010373750701546669,
0.025616569444537163,
-0.000229174445848912,
0.019188441336154938,
-0.011507068760693073,
0.030917376279830933,
-0.011944804340600967,
0.03554658591747284,
0.0037477423902601004,
-0.016418110579252243,
-0.01095540076494217,
-0.006266225595027208,
0.011111306957900524,
0.001464617787860334,
-0.022018736228346825,
0.037369489669799805,
0.024992944672703743,
-0.01846887543797493,
-0.0035228778142482042,
0.015782492235302925,
0.0014578718692064285,
-0.011549043469130993,
0.01437933836132288,
-0.01309611089527607,
0.014427308924496174,
-0.025616569444537163,
-0.021371126174926758,
0.006248236168175936,
-0.022486453875899315,
-0.004419337958097458,
0.0016729922499507666,
-0.0007727845222689211,
-0.017329560592770576,
0.011309187859296799,
-0.011435111984610558,
0.018648765981197357,
-0.020063914358615875,
-0.04293413832783699,
-0.05550256744027138,
0.01801314949989319,
0.0025559603236615658,
-0.035882383584976196,
-0.02314605750143528,
-0.023182036355137825,
0.007519470527768135,
0.04758733510971069,
-0.037825215607881546,
0.01574651524424553,
0.03482702001929283,
0.05051357299089432,
0.002271131845191121,
0.00023554560902994126,
0.006137303076684475,
0.03250042349100113,
0.006242239847779274,
0.005588633473962545,
0.0055496571585536,
0.020375726744532585,
0.014019555412232876,
-0.0064401207491755486,
0.03902449086308479,
0.0031690909527242184,
0.009108513593673706,
0.008526863530278206,
0.012700350023806095,
-0.025736497715115547,
0.02907048910856247,
0.006032366305589676,
-0.0029562192503362894,
-0.035258762538433075,
-0.01723361946642399,
-0.023937581107020378,
0.007159687113016844,
0.0005104425363242626,
-0.006889849901199341,
0.01767735183238983,
0.01879267953336239,
0.03772927448153496,
-0.017521444708108902,
-0.030437665060162544,
0.011435111984610558,
0.01978808082640171,
0.02626417949795723,
-0.013935605995357037,
-0.012508464977145195,
-0.0005194370751269162,
-0.0023595786187797785,
0.012616400606930256,
0.00416748970746994,
-0.04120717942714691,
-0.00648809177801013,
0.014007561840116978,
0.013815677724778652,
0.0059394221752882,
0.015458688139915466,
-0.006997784599661827,
0.011543046683073044,
-0.0043803611770272255,
-0.014799085445702076,
-0.030605563893914223,
0.016238218173384666,
-0.03343585878610611,
-0.007873257622122765,
-0.008880650624632835,
-0.0006543558556586504,
0.013036147691309452,
0.011585021391510963,
-0.026480048894882202,
0.0016580012161284685,
-0.016430102288722992,
-0.0074055390432477,
-0.019236411899328232,
-0.00939034391194582,
-0.021023336797952652,
0.009372354485094547,
-0.026360120624303818,
-0.01964416727423668,
-0.035114847123622894,
-0.006071342620998621,
0.0010688561014831066,
-0.016729922965168953,
-0.0428381972014904,
0.000023353120923275128,
-0.01692180708050728,
-0.014990969561040401,
-0.01635814644396305,
0.040247756987810135,
-0.0042754244059324265,
0.03828094154596329,
-0.03576245903968811,
0.024537218734622,
0.005246839486062527,
0.01566256582736969,
0.004947020206600428,
-0.014019555412232876,
-0.010805491358041763,
-0.012724335305392742,
-0.04425334185361862,
-0.033387888222932816,
-0.017485467717051506,
-0.01153705082833767,
-0.03310006111860275,
-0.012520457617938519,
0.01543470285832882,
-0.007543455809354782,
0.00596040952950716,
0.0114890793338418,
-0.03000592440366745,
-0.023745696991682053,
-0.008005177602171898,
0.0280630961060524,
-0.00841892883181572,
0.04245442524552345,
-0.030725492164492607,
-0.0067999036982655525,
-0.0011070831678807735,
0.033867597579956055,
-0.024513233453035355,
0.012424515560269356,
0.03118121810257435,
-0.028183022513985634,
-0.012856255285441875,
0.014151475392282009,
-0.0032170622143894434,
-0.046723853796720505,
0.0020042925607413054,
0.008119109086692333,
-0.0167539082467556,
0.0035468635614961386,
-0.003142107278108597,
0.010343769565224648,
0.010841469280421734,
0.0034479231107980013,
0.006458109710365534,
0.01087145134806633,
-0.025832438841462135,
0.010019964538514614,
0.004119518678635359,
-0.0014233925612643361,
0.013024154119193554,
-0.005660590250045061,
-0.033387888222932816,
0.01075152400881052,
0.023481855168938637,
0.010037953034043312,
0.015326767228543758,
-0.0046172188594937325,
-0.004194473382085562,
0.012448501773178577,
-0.025760482996702194,
-0.020867429673671722,
0.017413510009646416,
-0.000019488261386868544,
-0.010811487212777138,
0.007339579053223133,
0.0024974956177175045,
-0.0006820891285315156,
0.016070319339632988,
0.02205471508204937,
-0.011231234297156334,
-0.009006574749946594,
-0.003630812978371978,
-0.007879253476858139,
-0.016729922965168953,
0.007303600665181875,
0.13422314822673798,
-0.006128308363258839,
-0.011441107839345932,
0.004698169883340597,
0.024825045838952065,
-0.009768116287887096,
0.017953185364603996,
-0.004320397507399321,
0.005426730960607529,
-0.015062926337122917,
-0.0014676159480586648,
-0.00308813969604671,
0.035090863704681396,
0.018205033615231514,
0.026384107768535614,
-0.014871042221784592,
-0.010703552514314651,
0.0498899482190609,
-0.010535653680562973,
-0.021539025008678436,
0.025736497715115547,
0.007273618597537279,
0.0057085612788796425,
0.02571251057088375,
-0.03696173429489136,
-0.011285201646387577,
-0.00034704094287008047,
-0.0010711047798395157,
-0.0023745696526020765,
0.00197580992244184,
-0.007429524790495634,
0.01690981350839138,
0.021251197904348373,
-0.007771318778395653,
0.011459097266197205,
-0.03679383546113968,
-0.013192053884267807,
0.00021099789591971785,
-0.008388946764171124,
-0.0017629381036385894,
0.012058735825121403,
0.014463287778198719,
0.010427718982100487,
-0.004602227825671434,
0.03178085759282112,
0.004296411760151386,
-0.03878463804721832,
0.002304112073034048,
0.01507491897791624,
-0.016190247610211372,
-0.025928381830453873,
-0.00029475995688699186,
-0.0025904395151883364,
-0.02456120401620865,
-0.03552260249853134,
-0.0190924983471632,
0.030053896829485893,
-0.022102685645222664,
-0.0015268302522599697,
-0.012820277363061905,
-0.0018768694717437029,
0.014439302496612072,
0.024213414639234543,
-0.0070517524145543575,
0.009726141579449177
] | 2025-01-11 | 59 | 39794934 | [
"CAR)-T cell therapy",
"neuropsychological symptoms",
"neuropsychological assessments",
"CAR-T cell therapy",
"empirical studies",
"study characteristics",
"observational studies",
"other symptoms",
"different CAR-T cell products",
"CAR-T cells",
"immune effector cell-associated neurotoxicity syndrome",
"adult patients",
"side effects",
"effective strategies",
"cytokine release syndrome",
"Early intervention strategies",
"Quality assessment",
"patients",
"Observational Studies",
"randomized trials",
"memory loss",
"critical complications",
"cognitive impairment",
"impaired consciousness",
"attention deficits",
"Springer Link",
"Chimeric antigen receptor",
"living drugs",
"findings",
"psychomotor retardation"
] | [
"Chimeric antigen receptor - CAR",
"Cytokine release syndrome",
"Encephalitis",
"Immune effector cell-associated neurotoxicity syndrome - ICANS",
"Neurotoxicity"
] | 0 | 10.1136/jitc-2024-009174
10.1056/NEJMoa1707447
10.3389/fimmu.2022.876339
10.1080/14712598.2023.2248878
10.1056/NEJMc2309399
10.1182/blood.2021014892
10.1016/S1470-2045(22)00339-4
10.3324/haematol.2023.283940
10.1358/dot.2023.59.1.3509751
10.1016/S2352-3026(21)00057-0
10.6004/jadpro.2019.10.4.11
10.1016/j.annonc.2020.10.478
10.1158/2159-8290.CD-NB2017-169
10.1186/s13054-024-04851-0
10.1136/jitc-2020-001511
10.1007/s00415-020-10237-3
10.1158/2159-8290.CD-17-0698
10.1158/2159-8290.CD-17-1319
10.1186/s13046-021-02148-6
10.1056/NEJMoa1804980
10.1038/s41591-021-01564-7
10.1016/j.cell.2020.08.022
10.1093/brain/awz053
10.1007/s40263-018-0582-9
10.1182/blood.2023021860
10.1136/bmj.b2535
10.1038/nrclinonc.2017.148
10.1056/NEJMoa2024850
10.1016/j.bbmt.2018.12.758
10.1016/S2352-3026(21)00060-0
10.3389/fonc.2024.1434495
10.3324/haematol.2019.229781
10.1016/j.jtct.2023.04.001
10.1136/jitc-2021-003847
10.1182/blood-2022-165125
10.1007/s00281-024-01013-w
10.1038/s41591-023-02404-6
10.1200/JCO.20.01342
10.1038/s41408-023-00929-0
10.1186/s13045-024-01542-9
10.1016/j.annonc.2022.05.521
10.1182/bloodadvances.2023011492
10.1002/ajh.27069
10.1182/blood-2014-05-552729
10.1002/hon.2437_6
10.1016/S0140-6736(24)00815-8
10.1172/JCI162593
10.1056/NEJMoa1709866
10.1038/s41591-021-01436-0
10.1038/s41375-021-01232-2
10.1007/s12185-024-03809-w
10.1182/blood-2016-04-703751
10.1007/s00134-024-07576-4
10.1007/s12028-024-01995-3
10.1186/s42466-021-00166-5
10.1136/practneurol-2020-002550
10.1146/annurev-immunol-032712-095921
10.1182/blood-2010-08-301507
10.1136/jitc-2021-003486
10.1136/jitc-2021-003487 | [
"Fleischer",
"Kurth",
"Duell",
"Topp",
"Strunz",
"Mersi",
"Rasche",
"Sanges",
"Hudecek",
"Einsele",
"Maatouk"
] | [
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany [email protected].",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany.",
"Department of Internal Medicine II, University Hospital Wurzburg, Wurzburg, Germany."
] | [
"39794934",
"29226797",
"35493513",
"37599463",
"37733322",
"35507688",
"35839786",
"37731379",
"36811414",
"34048683",
"33520343",
"33098993",
"29208604",
"38444031",
"33335028",
"33140239",
"29025771",
"29880584",
"34794490",
"30501490",
"34893771",
"32961131",
"30891590",
"30387077",
"37796518",
"19622551",
"28925994",
"33626253",
"30592986",
"33894170",
"39364321",
"31753925",
"37031746",
"34996813",
"39012374",
"37400640",
"38947326",
"32701411",
"37833271",
"38644469",
"35690221",
"38113468",
"37668287",
"24876563",
"38996464",
"38502193",
"29385370",
"34312556",
"33833386",
"38963636",
"27207799",
"39172238",
"38806991",
"35000613",
"32503897",
"23330956",
"21252091",
"35577500",
"35577501"
] | [] | 6.147024 | 4.052469 |
39793572 | 46 | CD70-targeted iPSC-derived CAR-NK cells display potent function against tumors and alloreactive T cells. | Clinical application of autologous chimeric antigen receptor (CAR)-T cells is complicated by limited targeting of cancer types, as well as the time-consuming and costly manufacturing process. We develop CD70-targeted, induced pluripotent stem cell-derived CAR-natural killer (NK) (70CAR-iNK) cells as an approach for universal immune cell therapy. Besides the CD70-targeted CAR molecule, 70CAR-iNK cells are modified with CD70 gene knockout, a high-affinity non-cleavable CD16 (hnCD16), and an interleukin (IL)-15 receptor α/IL-15 fusion protein (IL15RF). Multi-gene-edited 70CAR-iNK cells exhibit robust cytotoxicity against a wide range of tumors. In vivo xenograft models further demonstrate their potency in effectively targeting lymphoma and renal cancers. Furthermore, we find that recipient alloreactive T cells express high levels of CD70 and can be eliminated by 70CAR-iNK cells, leading to improved survival and persistence of iNK cells. With the capability of tumor targeting and the potential to eliminate alloreactive T cells, 70CAR-iNK cells are potent candidates for next-generation universal immune cell therapy. | [
0.009228155948221684,
0.010516847483813763,
0.01918470300734043,
0.05737481266260147,
-0.04112608730792999,
-0.057150691747665405,
-0.019778622314333916,
0.06042284891009331,
-0.0041882493533194065,
-0.00007931759319035336,
0.001002238248474896,
-0.015654807910323143,
-0.0558507926762104,
0.01805289462208748,
0.025079067796468735,
-0.023218868300318718,
0.004319919738918543,
0.003213325748220086,
0.010690541006624699,
0.012864508666098118,
0.01317827682942152,
0.048947885632514954,
0.016237519681453705,
0.015374656766653061,
0.0016164680710062385,
-0.011508580297231674,
0.0164280217140913,
-0.02060786634683609,
-0.0240032896399498,
-0.03899694234132767,
0.005255622323602438,
-0.012068881653249264,
-0.03924347460269928,
-0.02846328541636467,
0.00024250523711089045,
0.026266906410455704,
0.03765222057700157,
0.028373638167977333,
-0.040655434131622314,
-0.024877360090613365,
0.05356476455926895,
0.0002542365400586277,
0.00812436267733574,
0.08686905354261398,
-0.06199169158935547,
0.018310632556676865,
-0.008376498706638813,
-0.016058223322033882,
0.03476106747984886,
-0.012942950241267681,
-0.014455762691795826,
0.006185722071677446,
-0.04621361941099167,
0.03765222057700157,
-0.04858929291367531,
0.05880918353796005,
-0.02319645695388317,
-0.029359767213463783,
-0.027947809547185898,
0.06526384502649307,
0.0105952899903059,
-0.01541948039084673,
0.02166123315691948,
-0.029158059507608414,
-0.034671418368816376,
-0.021851735189557076,
-0.042896635830402374,
-0.02978559583425522,
0.02649102546274662,
0.04437582939863205,
0.0025087471585720778,
0.005076325964182615,
0.004233073443174362,
0.00581592321395874,
0.012842096388339996,
0.002123540500178933,
-0.010606495663523674,
-0.0025129495188593864,
0.026603085920214653,
0.011133179068565369,
0.044465478509664536,
0.011217223480343819,
0.000541040557436645,
-0.035590313374996185,
0.02944941446185112,
-0.029158059507608414,
0.03706950694322586,
-0.043681059032678604,
-0.043882764875888824,
-0.00793946348130703,
-0.011228430084884167,
-0.0031096700113266706,
-0.03554548695683479,
0.045586079359054565,
-0.009188934229314327,
0.0187364611774683,
-0.03422318026423454,
-0.04625844210386276,
0.045182663947343826,
0.0430535189807415,
0.03278880938887596,
0.004745748359709978,
-0.004319919738918543,
-0.005121150054037571,
0.03957965597510338,
0.012741242535412312,
-0.034021470695734024,
0.041776034981012344,
0.03292328119277954,
0.001847592182457447,
0.0729287639260292,
-0.014399733394384384,
-0.0020493005868047476,
0.038481466472148895,
0.005860747303813696,
-0.06544314324855804,
-0.03462659567594528,
-0.005650634411722422,
0.002015682402998209,
0.03384217247366905,
-0.02346540242433548,
0.009872501716017723,
0.031914740800857544,
-0.03016659989953041,
-0.04336728900671005,
-0.023308517411351204,
0.06916354596614838,
0.016237519681453705,
-0.010875440202653408,
-0.044801659882068634,
0.02971835993230343,
0.004381552804261446,
0.013906667940318584,
-0.018579578027129173,
-0.058405764400959015,
0.0027062534354627132,
0.012685212306678295,
-0.007188660558313131,
-0.03258709982037544,
-0.016909880563616753,
-0.0006345407455228269,
-0.02965112403035164,
-0.011435741558670998,
0.005317255388945341,
-0.02689444273710251,
-0.028485696762800217,
-0.024899771437048912,
0.02097766473889351,
-0.009547526948153973,
0.06539832055568695,
-0.004692520014941692,
0.02563936822116375,
0.038167696446180344,
-0.0007220878032967448,
-0.017996864393353462,
-0.028440874069929123,
-0.02182932198047638,
0.06616032868623734,
-0.020697515457868576,
-0.03265433758497238,
0.005510559305548668,
0.014960033819079399,
-0.047423869371414185,
-0.020820781588554382,
-0.025930725038051605,
0.007816197350621223,
0.0023154434747993946,
0.025549720972776413,
-0.06042284891009331,
0.0034346445463597775,
-0.023084396496415138,
-0.02346540242433548,
-0.0710013285279274,
0.0022103870287537575,
-0.055895619094371796,
0.016080636531114578,
0.02911323495209217,
0.03801081329584122,
-0.010556069202721119,
0.0011794334277510643,
-0.007042982149869204,
0.001359430025331676,
0.035792022943496704,
-0.015722043812274933,
-0.04520507529377937,
0.01433249656111002,
-0.0068524801172316074,
-0.0025773842353373766,
-0.04805140569806099,
-0.017470182850956917,
0.028687406331300735,
-0.010225491598248482,
0.0743183121085167,
0.035523075610399246,
0.03016659989953041,
-0.021874146535992622,
0.03207162395119667,
0.021112138405442238,
-0.019969124346971512,
-0.05831611901521683,
0.0048073818907141685,
-0.014287672936916351,
-0.02965112403035164,
-0.02214309200644493,
-0.014097170904278755,
-0.012461092323064804,
-0.01656249538064003,
0.058988478034734726,
-0.013985110446810722,
0.031780265271663666,
0.06884977221488953,
0.020316511392593384,
0.013985110446810722,
0.060378026217222214,
-0.0003589427506085485,
-0.052354514598846436,
-0.0096932053565979,
0.03736086189746857,
-0.0022762224543839693,
0.017839981243014336,
-0.028306400403380394,
-0.02642378956079483,
-0.027253035455942154,
-0.0007206870359368622,
-0.041708797216415405,
0.00046154786832630634,
0.005418109707534313,
-0.010953882709145546,
0.00432832445949316,
-0.06087109073996544,
0.0037288025487214327,
0.04036407545208931,
0.020820781588554382,
-0.042179450392723083,
-0.05490948632359505,
0.004283500369638205,
0.01288692094385624,
-0.017021941021084785,
0.04567572847008705,
-0.014254054985940456,
-0.006891700904816389,
0.01632716879248619,
0.03754016011953354,
-0.028754642233252525,
-0.03574719652533531,
-0.019901888445019722,
0.012942950241267681,
-0.056299034506082535,
0.000040993891161633655,
-0.011228430084884167,
-0.01754862442612648,
-0.010802601464092731,
0.007070997264236212,
-0.006505093537271023,
0.025885900482535362,
0.043277639895677567,
0.047827284783124924,
-0.02306198514997959,
-0.014780737459659576,
-0.017873598262667656,
-0.006135294679552317,
-0.00014847973943687975,
-0.052488986402750015,
-0.022837864235043526,
-0.04215703904628754,
0.027432331815361977,
0.0003219979116693139,
0.06351570785045624,
0.007205469533801079,
0.0029611901845782995,
0.022972336038947105,
-0.01324551273137331,
0.051502857357263565,
-0.04220186173915863,
-0.048275526612997055,
0.022568920627236366,
-0.01013584341853857,
0.029987303540110588,
-0.02084319293498993,
-0.02523595280945301,
-0.016136664897203445,
0.030211424455046654,
0.0466618575155735,
-0.0010575678898021579,
-0.022972336038947105,
-0.011441344395279884,
0.004829793702811003,
0.019128672778606415,
0.01985706388950348,
-0.041305381804704666,
0.022826658561825752,
0.00106457166839391,
-0.021650027483701706,
-0.008348483592271805,
0.004291905090212822,
-0.005000685341656208,
-0.010107828304171562,
-0.0018377869855612516,
-0.0335284061729908,
-0.026916855946183205,
-0.007390368729829788,
-0.0038352597039192915,
0.0007599081145599484,
-0.044196534901857376,
-0.02091042883694172,
0.02911323495209217,
-0.0027020510751754045,
-0.025079067796468735,
0.012080087326467037,
0.028306400403380394,
0.029001174494624138,
-0.009004035033285618,
0.03675573691725731,
0.027454743161797523,
0.005518964026123285,
-0.011721494607627392,
0.01581169106066227,
-0.040050309151411057,
0.044599950313568115,
-0.0368005633354187,
-0.04101402685046196,
0.014870385639369488,
-0.03411111980676651,
0.023151632398366928,
0.022669773548841476,
0.0063818274065852165,
0.03897453099489212,
-0.03984859958291054,
0.046168792992830276,
-0.017929628491401672,
0.03937794640660286,
-0.04009513184428215,
0.031107906252145767,
-0.02176208607852459,
-0.00600082240998745,
-0.021537967026233673,
-0.046303264796733856,
-0.06997037678956985,
0.008970417082309723,
-0.05186145007610321,
0.03272157162427902,
0.04220186173915863,
-0.03917623683810234,
0.050113312900066376,
-0.008835945278406143,
-0.01952088251709938,
0.008191599510610104,
0.030076952651143074,
0.006118485704064369,
-0.008354086428880692,
-0.013010187074542046,
0.023779170587658882,
0.0161142535507679,
0.02050701342523098,
0.0054237125441432,
0.02207585610449314,
-0.006499490235000849,
0.004325523041188717,
0.009435467422008514,
0.004939052276313305,
0.020831987261772156,
0.013559281826019287,
-0.03148891031742096,
0.02622208185493946,
0.05329582095146179,
0.04935130104422569,
-0.000251435034442693,
0.0446895994246006,
-0.03337152302265167,
-0.034290414303541183,
0.0052192029543221,
0.0030256249010562897,
0.032631922513246536,
0.04574296623468399,
-0.04096920043230057,
0.022557714954018593,
0.03850387781858444,
0.006689992733299732,
0.01965535618364811,
-0.0019652554765343666,
0.04325522854924202,
-0.02700650319457054,
-0.006146500818431377,
-0.024070527404546738,
-0.0016080635832622647,
0.004939052276313305,
0.03384217247366905,
-0.0021109336521476507,
-0.05562667176127434,
0.037495337426662445,
-0.011598228476941586,
-0.029987303540110588,
0.03364046663045883,
-0.011822348460555077,
-0.009144110605120659,
0.046437736600637436,
-0.014836767688393593,
0.05876435711979866,
0.03249745070934296,
0.03393182158470154,
-0.02418258599936962,
-0.02047339454293251,
-0.013850637711584568,
-0.022893894463777542,
0.007356750778853893,
-0.04661703482270241,
0.04202256724238396,
0.02904599905014038,
0.013648930005729198,
-0.008034714497625828,
-0.0036251468118280172,
-0.02094404771924019,
0.01679782010614872,
0.02149314247071743,
0.029673535376787186,
-0.024473942816257477,
-0.05477501451969147,
0.032430216670036316,
-0.010275918059051037,
0.018826110288500786,
0.00987810455262661,
-0.06539832055568695,
-0.003403828013688326,
-0.035523075610399246,
-0.0013391191605478525,
-0.0021837728563696146,
0.039400357753038406,
0.005765496287494898,
-0.0013685349840670824,
-0.055312905460596085,
-0.0046196808107197285,
0.05661280080676079,
-0.00839891005307436,
-0.0335284061729908,
-0.004384354688227177,
0.02767886407673359,
-0.020260481163859367,
0.03308016434311867,
-0.01504968199878931,
0.07974202185869217,
-0.0479617565870285,
-0.015128124505281448,
-0.007580871228128672,
-0.00904885958880186,
0.03608337789773941,
0.011575816199183464,
0.016775408759713173,
0.025549720972776413,
-0.04711009934544563,
-0.013301542960107327,
-0.008040318265557289,
-0.008847150951623917,
0.017727920785546303,
-0.002648822497576475,
-0.0179184228181839,
-0.01297656912356615,
0.01535224448889494,
-0.05481984093785286,
-0.02983042038977146,
0.008090744726359844,
0.0023966871667653322,
-0.02944941446185112,
0.008326071314513683,
-0.007183057256042957,
-0.014545410871505737,
0.0525786355137825,
-0.013682547956705093,
-0.020719926804304123,
0.01958811841905117,
-0.03635232150554657,
-0.001479194383136928,
-0.00812436267733574,
-0.00872388482093811,
0.003986540716141462,
-0.015542746521532536,
0.04365864396095276,
-0.007861021906137466,
0.029628710821270943,
0.013951492495834827,
0.012528328225016594,
-0.036307498812675476,
-0.02206464856863022,
-0.01706676557660103,
-0.0021627615205943584,
0.059840135276317596,
0.01883731596171856,
-0.0045384373515844345,
-0.028485696762800217,
0.0020535027142614126,
0.032766398042440414,
0.009149713441729546,
0.009295391850173473,
0.03561272472143173,
-0.008740694262087345,
-0.011743906885385513,
-0.016977116465568542,
0.06275369971990585,
0.007390368729829788,
-0.01699952967464924,
0.022468065842986107,
-0.017021941021084785,
0.011329283937811852,
-0.0014154601376503706,
0.027566803619265556,
0.06844636052846909,
0.04399482533335686,
0.02516871690750122,
0.050068486481904984,
-0.016349580138921738,
0.02366711013019085,
-0.045586079359054565,
0.01903902366757393,
0.014769531786441803,
-0.03379734978079796,
-0.01649525761604309,
-0.009726823307573795,
-0.03700227290391922,
-0.0031432879623025656,
-0.027365095913410187,
-0.004440384451299906,
-0.028418460860848427,
-0.017335709184408188,
0.003880083793774247,
0.018445106223225594,
0.02023806795477867,
-0.006818861700594425,
-0.057554107159376144,
-0.03337152302265167,
-0.021975001320242882,
-0.03709191828966141,
0.021952589973807335,
0.006034440826624632,
0.015251390635967255,
0.034155942499637604,
-0.025751428678631783,
-0.0279253963381052,
-0.029225295409560204,
-0.0027160586323589087,
0.011374108493328094,
-0.038481466472148895,
0.016909880563616753,
-0.01683143898844719,
0.02812710404396057,
-0.016786614432930946,
-0.01713400147855282,
0.020361334085464478,
0.012494710274040699,
-0.027051327750086784,
0.008040318265557289,
0.021481936797499657,
0.0229947492480278,
-0.02608761005103588,
-0.005465735215693712,
-0.024160174652934074,
0.0035523076076060534,
-0.018254602327942848,
-0.016170283779501915,
-0.0022678179666399956,
-0.008942401967942715,
0.0033702098298817873,
-0.05087532103061676,
0.0008425524574704468,
0.005446124821901321,
-0.03036830946803093,
-0.006163309793919325,
0.020092390477657318,
0.013424809090793133,
-0.011788730509579182,
-0.03570237383246422,
0.04298628494143486,
-0.014948828145861626,
-0.00030151192913763225,
0.0030564414337277412,
-0.012472297996282578,
0.06763952225446701,
0.02182932198047638,
-0.0017971651395782828,
0.032430216670036316,
-0.013973904773592949,
0.02221032790839672,
-0.021504348143935204,
-0.012169735506176949,
-0.009900516830384731,
0.03520930930972099,
-0.02628931775689125,
0.0009497100254520774,
-0.08063850551843643,
-0.01327913161367178,
-0.006140897981822491,
0.0033141798339784145,
0.026378966867923737,
0.018209779635071754,
0.05020296201109886,
0.016809027642011642,
-0.06261923164129257,
0.020159626379609108,
-0.01209129299968481,
-0.008258835412561893,
0.026737559586763382,
-0.006454666145145893,
-0.001352426246739924,
-0.009071271866559982,
0.006135294679552317,
-0.03162338212132454,
0.00911609549075365,
-0.0013622315600514412,
-0.008964814245700836,
-0.0009644179372116923,
-0.0004055177851114422,
0.005149165168404579,
0.05298205092549324,
0.011844760738313198,
-0.004555246327072382,
0.049396127462387085,
0.020854398608207703,
0.02326369285583496,
-0.015733249485492706,
0.005446124821901321,
-0.001701914006844163,
-0.034940365701913834,
-0.027970220893621445,
-0.006953333970159292,
-0.016315961256623268,
0.005888762418180704,
-0.013290337286889553,
-0.034155942499637604,
-0.009441070258617401,
0.005574993789196014,
0.013211894780397415,
-0.006891700904816389,
0.003838061122223735,
-0.035007599741220474,
-0.03030107170343399,
0.039400357753038406,
-0.010259109549224377,
-0.03603855520486832,
0.01890455186367035,
-0.01193440891802311,
0.0073455446399748325,
-0.007597680203616619,
-0.020652690902352333,
0.03281122073531151,
-0.0014637861168012023,
-0.022154297679662704,
0.030144188553094864,
0.006331400014460087,
-0.042089805006980896,
-0.016002193093299866,
0.01209129299968481,
-0.017559830099344254,
0.003182508982717991,
-0.0417536236345768,
0.0023574659135192633,
-0.025527309626340866,
0.004420774057507515,
-0.01870284415781498,
-0.0007185859140008688,
-0.004608474671840668,
0.04202256724238396,
0.0743183121085167,
-0.015923751518130302,
0.019700178876519203,
0.0076537104323506355,
-0.01710038259625435,
-0.0032777602318674326,
-0.006365017965435982,
-0.005367682781070471,
0.028866702690720558,
0.0008026310242712498,
0.00047695613466203213,
0.06194686517119408,
0.020013948902487755,
-0.0038968927692621946,
-0.016103047877550125,
-0.01225938368588686,
-0.0012319616507738829,
-0.017302092164754868,
-0.021212991327047348,
-0.0073791625909507275,
-0.008286850526928902,
0.005213599652051926,
-0.006802052725106478,
-0.03063725307583809,
-0.0677291750907898,
0.019812239333987236,
0.010460817255079746,
0.04128297045826912,
0.013794608414173126,
-0.018725255504250526,
-0.049978841096162796,
-0.00767612224444747,
-0.017335709184408188,
-0.02846328541636467,
0.00164728460367769,
0.021381082013249397,
0.02060786634683609,
0.006633962504565716,
-0.009205743670463562,
-0.013032598420977592,
-0.01819857396185398,
0.006538711488246918,
0.0032301347237080336,
0.018792491406202316,
-0.01135729905217886,
0.011234032921493053,
-0.0008110355702228844,
-0.015789279714226723,
-0.0057710991241037846,
-0.003000411204993725,
0.03260951116681099,
0.011755112558603287,
-0.005600207485258579,
-0.009721220470964909,
-0.01955450139939785,
-0.005426513962447643,
-0.016584906727075577,
0.013704960234463215,
0.01426526065915823,
0.0013650330947712064,
0.009446673095226288,
0.012293001636862755,
0.013402397744357586,
-0.007014967035502195,
0.009390642866492271,
0.04823070019483566,
0.012136117555201054,
-0.037562571465969086,
0.05074084922671318,
0.0018321839161217213,
-0.005849541164934635,
0.007838609628379345,
-0.03561272472143173,
-0.041507091373205185,
-0.00007669118349440396,
-0.026378966867923737,
0.027028914541006088,
-0.041641563177108765,
-0.01905023120343685,
-0.0028365233447402716,
-0.006353812292218208,
0.0331922248005867,
-0.01795203983783722,
-0.023958466947078705,
0.0027118562720716,
-0.01785118691623211,
0.03547825291752815,
0.02264736220240593,
-0.0358368456363678,
-0.00002385656080150511,
-0.03722639009356499,
-0.01577807404100895,
0.006661977618932724,
-0.011665464378893375,
-0.0114973746240139,
-0.01142453495413065,
-0.043277639895677567,
0.004555246327072382,
0.012550740502774715,
-0.03343875706195831,
-0.005112745799124241,
-0.03050278127193451,
-0.005544177256524563,
-0.00419105077162385,
0.02965112403035164,
-0.009474688209593296,
-0.0041882493533194065,
0.0006082766340114176,
0.014108376577496529,
-0.019677767530083656,
0.025011831894516945,
-0.003947319928556681,
0.014489381574094296,
0.00902644731104374,
-0.021605202928185463,
-0.012169735506176949,
0.008751899935305119,
-0.02162761427462101,
-0.01771671511232853,
-0.04314316809177399,
0.03016659989953041,
-0.014511792920529842,
-0.01656249538064003,
-0.01778395101428032,
-0.00573748117312789,
0.022826658561825752,
-0.02438429556787014,
-0.011542198248207569,
-0.0006825165473856032,
-0.025079067796468735,
-0.03272157162427902,
-0.02115696109831333,
0.03370770066976547,
-0.009648381732404232,
0.03659885376691818,
-0.0269616786390543,
0.03254227712750435,
0.030614841729402542,
-0.08731728792190552,
-0.02274821698665619,
-0.0032357375603169203,
0.011833555065095425,
-0.022098267450928688,
0.027185799553990364,
-0.05343029275536537,
-0.02669273503124714,
-0.0017285282956436276,
0.006421048194169998,
-0.0021445516031235456,
-0.0010806804057210684,
0.012349031865596771,
-0.0024064923636615276,
0.008157980628311634,
-0.03718156740069389,
-0.013122246600687504,
-0.06396394968032837,
-0.010046195238828659,
0.034290414303541183,
-0.0009889310458675027,
-0.008337276987731457,
0.018714049831032753,
0.021212991327047348,
-0.0065499176271259785,
0.00007909872510936111,
-0.0005508458125405014,
-0.01096508838236332,
-0.04332246631383896,
-0.031645793467760086,
0.005115547217428684,
-0.004305912181735039,
-0.039534829556941986,
0.018131336197257042,
-0.005776702426373959,
-0.02418258599936962,
0.020361334085464478,
-0.01775033213198185,
0.023913642391562462,
0.008544588461518288,
-0.015990987420082092,
0.019935505464673042,
0.020585455000400543,
-0.0037344053853303194,
-0.025392835959792137,
0.008550191298127174,
-0.007003761362284422,
0.011183605529367924,
0.016775408759713173,
-0.015901340171694756,
0.041843269020318985,
-0.034873127937316895,
-0.04639291390776634,
0.006695595569908619,
-0.012214559130370617,
-0.015553953126072884,
-0.004891426768153906,
0.03435765206813812,
-0.008914386853575706,
0.03511966019868851,
-0.00280570681206882,
0.02516871690750122,
0.033035341650247574,
-0.005390094593167305,
-0.01850113645195961,
-0.0045328340493142605,
-0.029494239017367363,
0.020114801824092865,
-0.014836767688393593,
0.0075528561137616634,
-0.024899771437048912,
0.00018892645312007517,
-0.03444729745388031,
0.020081184804439545,
0.007928257808089256,
0.005510559305548668,
-0.009900516830384731,
-0.00889197550714016,
0.009172125719487667,
0.04477924853563309,
-0.02478771097958088,
-0.01840028166770935,
-0.036060966551303864,
-0.009037652984261513,
-0.04215703904628754,
0.011553404852747917,
-0.00015241935034282506,
0.007614489179104567,
-0.02271459810435772,
-0.024339471012353897,
-0.0021151357796043158,
-0.03686779737472534,
-0.006925318855792284,
-0.027634039521217346,
-0.025392835959792137,
-0.02012600749731064,
-0.04585502669215202,
0.0033702098298817873,
0.006068058777600527,
-0.026984091848134995,
0.04484648257493973,
-0.009799662977457047,
-0.0002139649004675448,
-0.03594890609383583,
-0.029628710821270943,
-0.014141994528472424,
0.038548700511455536,
0.024608414620161057,
0.002145952545106411,
-0.016405610367655754,
0.05880918353796005,
0.008107554167509079,
-0.004429178778082132,
-0.02570660598576069,
0.0047149318270385265,
0.005177180282771587,
0.03673332557082176,
-0.023106809705495834,
-0.00940184947103262,
0.0038100460078567266,
0.051233913749456406,
0.020383747294545174,
-0.005499353166669607,
-0.044398244470357895,
-0.012942950241267681,
-0.004361942410469055,
0.022333594039082527,
0.01498244609683752,
0.018848521634936333,
-0.006953333970159292,
0.009844486601650715,
-0.011676670983433723,
0.021537967026233673,
-0.00407338747754693,
-0.03655403107404709,
0.026266906410455704,
0.025661781430244446,
0.020563043653964996,
-0.0014918011147528887,
-0.0016318763373419642,
-0.009704411961138248,
-0.023510225117206573,
0.016674553975462914,
-0.012349031865596771,
0.04455512762069702,
-0.003801641520112753,
-0.029920067638158798,
0.03686779737472534,
0.022703392431139946,
-0.013066217303276062,
-0.03476106747984886,
0.036912623792886734,
0.03836940601468086,
0.046841155737638474,
-0.010012577287852764,
0.028821878135204315,
0.04612397029995918,
-0.020865606144070625,
-0.028821878135204315,
0.018310632556676865,
-0.003992144018411636,
0.03281122073531151,
-0.028104692697525024,
-0.010679335333406925,
0.006998158060014248,
-0.013200689107179642,
-0.009922929108142853,
0.02030530385673046,
0.0179184228181839,
0.04471201077103615,
0.0046252841129899025,
-0.043613821268081665,
0.03926588594913483,
0.00034423486795276403,
-0.007704137358814478,
-0.0006362916901707649,
0.0302338358014822,
-0.015184154734015465,
0.01373857818543911,
0.02740992046892643,
-0.012203353457152843,
0.0069477311335504055,
0.036643680185079575,
0.018725255504250526,
0.04462236166000366,
-0.019610531628131866,
-0.0040649832226336,
-0.025527309626340866,
0.012304207310080528,
-0.0057710991241037846,
-0.020787162706255913,
-0.03438006341457367,
0.0031432879623025656,
0.05513360723853111,
0.004168638493865728,
-0.021885352209210396,
-0.0644570142030716,
0.025056656450033188,
-0.038279756903648376,
-0.023039571940898895,
-0.02101128362119198,
0.030121775344014168,
0.03951241821050644,
-0.034873127937316895,
-0.03666609153151512,
0.0279253963381052,
0.00424988241866231,
-0.02424982190132141,
-0.007933860644698143,
0.041910506784915924,
0.013335160911083221,
0.05186145007610321,
-0.028687406331300735,
0.0308837853372097,
0.027118563652038574,
0.008051523938775063,
0.002197780180722475,
-0.0007683126023039222,
-0.019946711137890816,
-0.003297370858490467,
-0.016887469217181206,
-0.008970417082309723,
0.007883433252573013,
0.006213736720383167,
-0.012662800028920174,
-0.016147872433066368,
0.003344996366649866,
0.019095053896307945,
0.013335160911083221,
0.012427473440766335,
-0.04258286952972412,
0.027656452730298042,
0.035657547414302826,
0.017358122393488884,
0.012662800028920174,
-0.011021118611097336,
-0.0017705508507788181,
-0.03709191828966141,
-0.008684664033353329,
-0.013716165907680988,
0.04070025682449341,
0.02359987422823906,
-0.008768709376454353,
-0.013749783858656883,
-0.016237519681453705,
0.014948828145861626,
0.04096920043230057,
-0.03142167255282402,
-0.024832535535097122,
-0.017358122393488884,
-0.0404089018702507,
-0.021168168634176254,
0.04507060348987579,
0.005591802764683962,
0.011379711329936981,
0.011743906885385513,
0.029202882200479507,
0.02543766051530838,
0.01833304576575756,
0.02478771097958088,
0.005210798233747482,
-0.011015515774488449,
-0.00909368321299553,
-0.023756757378578186,
0.017806362360715866,
-0.009188934229314327,
0.03137684985995293,
-0.012438680045306683,
0.02037253975868225,
0.02186294086277485,
0.03935553506016731,
0.0016921086935326457,
-0.017077971249818802,
-0.0014427747810259461,
-0.01209129299968481,
-0.034469712525606155,
0.022658567875623703,
0.02720821090042591,
0.011250842362642288,
0.02251289039850235,
0.0059447926469147205,
-0.023577461019158363,
-0.03601614013314247,
0.00004688142507802695,
0.008746297098696232,
0.015957370400428772,
-0.009306597523391247,
-0.02602037414908409,
0.003269355744123459,
0.0001263303420273587,
-0.02754439227283001,
-0.0007437994354404509,
-0.0259531382471323,
-0.004664504900574684,
-0.021750880405306816,
-0.004479605704545975,
0.0058047170750796795,
-0.015228978358209133,
-0.010516847483813763,
-0.017167620360851288,
0.017996864393353462,
0.010987500660121441,
-0.03036830946803093,
-0.030009716749191284,
0.01564360037446022,
-0.013010187074542046,
-0.033281873911619186,
-0.06396394968032837,
0.06356053054332733,
-0.013536869548261166,
-0.03996066004037857,
0.0022692186757922173,
0.021403493359684944,
-0.031914740800857544,
0.02431705966591835,
-0.0015618387842550874,
-0.023913642391562462,
0.030592428520321846,
0.022299975156784058,
-0.0013762391172349453,
0.012136117555201054,
0.0105952899903059,
0.007155042607337236,
0.002657226985320449,
0.0021179374307394028,
-0.012416267767548561,
0.019173497334122658,
0.015934957191348076,
-0.031981974840164185,
-0.02292751334607601,
0.03417835384607315,
-0.01761586032807827,
0.00432832445949316,
-0.0010071408469229937,
-0.0023672713432461023,
0.01498244609683752,
-0.010516847483813763,
0.00025528710102662444,
0.004723336547613144,
0.01636078581213951,
-0.01636078581213951,
0.011026721447706223,
-0.001774753094650805,
0.015901340171694756,
-0.009631572291254997,
0.008342880755662918,
-0.019980330020189285,
0.0047681606374681,
-0.023218868300318718,
-0.017190031707286835,
0.04711009934544563,
-0.02132505178451538,
-0.04016236960887909,
0.06719128042459488,
-0.007720946334302425,
0.004431980196386576,
0.018658019602298737,
-0.008634236641228199,
-0.00819720234721899,
-0.010331948287785053,
-0.023420577868819237,
-0.012068881653249264,
0.03632991015911102,
-0.026670321822166443,
-0.003961327485740185,
-0.000696173869073391,
-0.021975001320242882,
0.011687876656651497,
-0.005530169699341059,
0.005555383395403624,
0.024160174652934074,
0.022524096071720123,
-0.031040670350193977,
0.005093134939670563,
0.036710914224386215,
0.0063818274065852165,
0.02944941446185112,
0.007244690787047148,
0.005701061803847551,
0.039064180105924606,
0.017896011471748352,
-0.0076481071300804615,
0.003140486543998122,
-0.019801033660769463,
0.013267925009131432,
-0.018557164818048477,
-0.03561272472143173,
-0.03975895047187805,
0.01897178776562214,
-0.029673535376787186,
-0.009329009801149368,
-0.0008460543467663229,
0.01587892696261406,
-0.009396245703101158,
-0.010925867594778538,
-0.029090821743011475,
0.006449063308537006,
0.003501880681142211,
-0.023846406489610672,
0.017492594197392464,
-0.033035341650247574,
0.01775033213198185,
0.0162599328905344,
-0.0022720200940966606,
0.015296214260160923,
0.038481466472148895,
0.0005445424467325211,
0.04356899857521057,
0.0059784105978906155,
-0.00870707631111145,
-0.004283500369638205,
0.024608414620161057,
-0.04885823652148247,
-0.014702295884490013,
-0.020114801824092865,
-0.008813533000648022,
-0.015206566080451012,
-0.026916855946183205,
-0.0033393932972103357,
-0.010942676104605198,
0.01724606193602085,
0.01343601569533348,
-0.00600082240998745,
-0.02622208185493946,
-0.028373638167977333,
0.009239361621439457,
0.016024606302380562,
0.002725863829255104,
-0.026378966867923737,
0.06033319979906082,
-0.0025535712484270334,
-0.02012600749731064,
0.02050701342523098,
-0.0018377869855612516,
-0.040520962327718735,
-0.0017663486069068313,
-0.022165503352880478,
0.0004097200289834291,
-0.019016612321138382,
0.014310085214674473,
-0.012136117555201054,
-0.013200689107179642,
0.03359564021229744,
0.023555049672722816,
-0.002190776402130723,
-0.010533656924962997,
-0.019307969138026237,
0.011267650872468948,
-0.0059447926469147205,
0.008639839477837086,
0.0011381112271919847,
0.03561272472143173,
-0.018142543733119965,
-0.030794138088822365,
-0.013850637711584568,
0.00619692774489522,
-0.038414228707551956,
-0.017806362360715866,
0.0066451686434447765,
0.011575816199183464,
-0.057554107159376144,
0.00023252487881109118,
0.008550191298127174,
0.0381452850997448,
0.004331125877797604,
-0.024429118260741234,
0.0017341312486678362,
0.01348083931952715,
-0.007003761362284422,
0.012203353457152843,
0.006992555223405361,
0.007227881345897913,
0.0335284061729908,
0.004275095649063587,
0.03108549304306507,
-0.014209230430424213,
0.03090619668364525,
0.020226862281560898,
0.00309846387244761,
-0.0381004624068737,
-0.019599325954914093,
0.03343875706195831,
-0.014254054985940456,
-0.01489279791712761,
0.0009735227795317769,
0.028911525383591652,
0.012158529832959175,
-0.037047095596790314,
0.03975895047187805,
0.0030480369459837675,
-0.0034542549401521683,
-0.014466969296336174,
-0.018792491406202316,
-0.004039769526571035,
0.004216264467686415,
0.01472470723092556,
0.00992853194475174,
0.018456311896443367,
0.006757228635251522,
-0.021638819947838783,
-0.004308714065700769,
0.004196653608232737,
0.018489928916096687,
-0.0008957810350693762,
-0.007452001795172691,
-0.009754838421940804,
-0.039871010929346085,
-0.06477078050374985,
0.021952589973807335,
0.013155865482985973,
-0.03359564021229744,
-0.014041140675544739,
0.00450481940060854,
-0.005580597091466188,
0.016752997413277626,
-0.035388603806495667,
-0.01928555592894554,
0.014803149737417698,
0.01521777268499136,
0.0020647088531404734,
0.004995082505047321,
0.026715146377682686,
0.029539063572883606,
-0.020025154575705528,
-0.0031544941011816263,
-0.02159399725496769,
-0.007278308738023043,
0.03003212809562683,
-0.030211424455046654,
0.01679782010614872,
0.00800669938325882,
-0.00909368321299553,
0.007054188288748264,
-0.017940834164619446,
0.0018265809630975127,
0.04265010356903076,
0.0016444831853732467,
-0.006353812292218208,
0.006152103655040264,
-0.021448317915201187,
-0.01037117000669241,
-0.0016220711404457688,
0.04291904717683792,
0.004417972639203072,
0.012707624584436417,
0.0253031887114048,
0.058136820793151855,
-0.001683704205788672,
-0.007592077367007732,
0.02747715637087822,
0.028216753154993057,
0.010444008745253086,
-0.0002757730835583061,
0.016315961256623268,
0.016215108335018158,
-0.016271138563752174,
-0.007973081432282925,
0.004894228186458349,
-0.04594467207789421,
-0.0038436641916632652,
-0.00601202854886651,
-0.0072502936236560345,
0.026042785495519638,
0.018691638484597206,
0.007104615215212107,
-0.01373857818543911,
-0.014220437034964561,
-0.026244493201375008,
-0.05114426463842392,
-0.009822074323892593,
-0.011587022803723812,
0.018377868458628654,
-0.007087806239724159,
-0.016282344236969948,
-0.029695946723222733,
0.01581169106066227,
-0.021975001320242882,
0.019946711137890816,
0.016887469217181206,
0.0004657501121982932,
-0.009379437193274498,
0.01013584341853857,
-0.010264712385833263,
0.005799114238470793,
-0.06490525603294373,
-0.026737559586763382,
-0.0315561480820179,
-0.009721220470964909,
-0.015027269721031189,
0.010483229532837868,
-0.057016219943761826,
-0.009519511833786964,
0.018994200974702835,
-0.0120016448199749,
-0.0010876840678974986,
0.028889114037156105,
0.007390368729829788,
0.01609184220433235,
-0.027656452730298042,
-0.0020745140500366688,
0.001877008005976677,
0.02060786634683609,
0.01669696718454361,
-0.023913642391562462,
0.011710288934409618,
-0.018041688948869705,
0.0034962776117026806,
-0.037047095596790314,
-0.02445153146982193,
0.015453098341822624,
-0.03267674893140793,
-0.0026334142312407494,
-0.005236011929810047,
0.0095363212749362,
-0.004345133434981108,
0.03209403529763222,
-0.023689521476626396,
0.02472047507762909,
-0.002277623163536191,
0.011312475427985191,
0.03563513606786728,
0.04917200654745102,
-0.01387304998934269,
0.018926965072751045,
0.01632716879248619,
0.041843269020318985,
-0.007003761362284422,
0.013189483433961868,
0.012427473440766335,
-0.012461092323064804,
-0.004384354688227177,
0.052488986402750015,
0.016383199021220207,
-0.027230624109506607,
0.008354086428880692,
-0.003958525601774454,
0.011301268823444843,
0.023353341966867447,
-0.04988919198513031,
0.004569253884255886,
-0.010415993630886078,
0.01577807404100895,
-0.003076051827520132,
0.040453724563121796,
-0.03146649897098541,
0.007508032023906708,
-0.0030732504092156887,
-0.013099835254251957,
0.02398087829351425,
0.0033337902277708054,
-0.012124910950660706,
0.02033892273902893,
0.0029723963234573603,
-0.013010187074542046,
0.025616956874728203,
0.02642378956079483,
-0.0012375646037980914,
0.02204223722219467,
-0.021168168634176254,
-0.013660135678946972,
0.04022960364818573,
-0.010634510777890682,
0.010091018863022327,
0.01903902366757393,
0.018893346190452576,
0.0246532391756773,
0.042762164026498795,
0.006359415128827095,
-0.011833555065095425,
-0.017537418752908707,
-0.03153373301029205,
0.020820781588554382,
-0.03505242243409157,
0.008219613693654537,
0.10336431115865707,
-0.023958466947078705,
-0.0016080635832622647,
0.018814904615283012,
0.008298056200146675,
-0.013312749564647675,
0.04253804311156273,
0.004196653608232737,
0.030413132160902023,
-0.02740992046892643,
0.02301716059446335,
0.006084867753088474,
0.017996864393353462,
0.00011880129750352353,
0.03639714792370796,
-0.0007879231125116348,
0.005437720101326704,
0.013391191139817238,
-0.009894913993775845,
-0.009334612637758255,
-0.0031881120521575212,
0.029135646298527718,
-0.024877360090613365,
0.032116446644067764,
-0.016472846269607544,
-0.0009153916034847498,
-0.011183605529367924,
0.0010841821786016226,
-0.001697711762972176,
-0.011329283937811852,
0.026266906410455704,
0.010500038973987103,
0.002690844936296344,
-0.012136117555201054,
-0.011587022803723812,
-0.010981897823512554,
0.0015982582699507475,
-0.000059531968872761354,
0.01169908232986927,
0.0029415797907859087,
0.02125781588256359,
-0.006264164112508297,
-0.000027664857043419033,
0.03998307138681412,
0.02281545288860798,
0.0003876581904478371,
-0.0190726425498724,
-0.017145207151770592,
0.015699630603194237,
-0.04594467207789421,
-0.007463207934051752,
-0.022501684725284576,
0.027970220893621445,
-0.017873598262667656,
-0.023689521476626396,
-0.007995493710041046,
0.010180667042732239,
-0.009922929108142853,
-0.020013948902487755,
-0.014399733394384384,
-0.027656452730298042,
0.0075528561137616634,
0.02846328541636467,
-0.0126515943557024,
0.008852753788232803
] | 2025-01-11 | 1 | 39793572 | [
"iNK cells",
"CAR)-T cells",
"universal immune cell therapy",
"CD70 gene knockout",
"autologous chimeric antigen receptor",
"70CAR-iNK cells",
"next-generation universal immune cell therapy",
"recipient alloreactive T cells",
"70CAR",
"alloreactive T cells",
"cancer types",
"CD70",
"gene-edited 70CAR-iNK cells",
"high levels",
"renal cancers",
"vivo xenograft models",
"limited targeting",
"IL)-15 receptor α/IL-15 fusion protein",
"robust cytotoxicity",
"potent candidates",
"CAR",
"improved survival",
"Clinical application",
"tumors",
"the CD70-targeted CAR molecule",
"hnCD16",
"a high-affinity non-cleavable CD16",
"lymphoma",
"NK",
"persistence"
] | [
"CD70",
"allogeneic rejection",
"chimeric antigen receptor",
"induced pluripotent stem cell",
"multiplex gene editing",
"natural killer cell"
] | 0 | 10.1016/j.xcrm.2024.101889 | [
"Wang",
"Wang",
"He",
"Mo",
"Zhao",
"Liang",
"Hu",
"Wang",
"Yue",
"Mo",
"Zhou",
"Hong",
"Zhou",
"Feng",
"Chen",
"Shen",
"Song",
"Zeng",
"Jia",
"Shao",
"Zhang",
"Xu",
"Wang",
"Hu",
"Yang",
"Huang"
] | [
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Qihan Biotech Inc., Hangzhou 311200, China.",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China. Electronic address: [email protected].",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China. Electronic address: [email protected].",
"Qihan Biotech Inc., Hangzhou 311200, China. Electronic address: [email protected].",
"Bone Marrow Transplantation Center of the First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou 311121, China; Institute of Hematology, Zhejiang University, Hangzhou 310058, China; Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy, Hangzhou 310058, China. Electronic address: [email protected]."
] | [
"39793572"
] | [] | 11.261157 | 5.80868 |
39792660 | 47 | Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells. | Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART immune synapse (CARIS) could explain differences in their tumor rejection kinetics. We observed that CD28.ζ-CART engaged in brief highly lethal CARIS and mastered serial killing, whereas 4-1BB.ζ-CART formed lengthy CARIS and relied on robust expansion and cooperative killing. We analyzed CARIS membrane lipid rafts (mLRs) and found that, upon tumor engagement, CD28.ζ-CAR molecules rapidly but transiently translocated into mLRs, mobilizing the microtubular organizing center and lytic granules to the CARIS. This enabled fast CART recovery and sensitivity to low target site density. In contrast, gradual accumulation of 4-1BB.ζ-CAR and LFA-1 molecules at mLRs built mechanically tonic CARIS mediating chronic Fas ligand-based killing. The differences in CD28.ζ- and 4-1BB.ζ-CARIS dynamics explain the distinct cytolytic behavior of CART and can guide engineering of more adaptive effective cellular products. | [
0.02868328057229519,
0.016721079126000404,
-0.0005586966290138662,
0.06683230400085449,
-0.04522232711315155,
0.030035529285669327,
-0.011916694231331348,
0.0056495401076972485,
-0.02635585330426693,
-0.002971047069877386,
0.007664911448955536,
0.014510671608150005,
-0.030763663351535797,
0.03770694136619568,
0.024951593950390816,
-0.043844074010849,
0.029645457863807678,
0.00608837092295289,
-0.008653093129396439,
0.014419655315577984,
0.020270731300115585,
-0.0022380370646715164,
0.013574499636888504,
0.003258724929764867,
-0.03617265820503235,
-0.02707098424434662,
0.054766084998846054,
-0.0004457383183762431,
-0.007833942770957947,
-0.02917737141251564,
0.03289605677127838,
-0.021492958068847656,
-0.029957516118884087,
-0.019308555871248245,
-0.0523996464908123,
0.050007205456495285,
-0.0001405883813276887,
0.0025858511216938496,
-0.014614691026508808,
0.006046113092452288,
0.02644686959683895,
0.025250649079680443,
-0.02296222746372223,
0.02021872252225876,
-0.011546125635504723,
-0.020504774525761604,
0.00047621267731301486,
-0.015472848899662495,
0.024886582046747208,
0.00713181309401989,
-0.019607611000537872,
0.023183267563581467,
-0.01854141429066658,
0.042673856019973755,
-0.06594814360141754,
0.006741741206496954,
0.008510067127645016,
0.022988231852650642,
-0.002452576532959938,
0.027305027469992638,
0.006029860116541386,
-0.03887715935707092,
0.014926748350262642,
-0.038565099239349365,
-0.0461064875125885,
0.002281920053064823,
-0.040411438792943954,
-0.04426014795899391,
0.018320372328162193,
0.03786297142505646,
-0.019308555871248245,
-0.02813718095421791,
0.03326012194156647,
0.019607611000537872,
0.057418569922447205,
-0.0023989416658878326,
-0.003036058973520994,
0.027747109532356262,
0.0005107502802275121,
-0.011071538552641869,
0.03141378238797188,
0.006588963326066732,
0.0025614716578274965,
-0.08404747396707535,
0.008906640112400055,
-0.03523648902773857,
0.016344008967280388,
0.006104623898863792,
-0.03918921574950218,
-0.002280294895172119,
-0.0076454076915979385,
0.022312108427286148,
-0.047822803258895874,
0.008958649821579456,
-0.006595464423298836,
0.0056950487196445465,
-0.01860642619431019,
-0.04204974323511124,
-0.005600781179964542,
0.023742372170090675,
0.030009524896740913,
-0.04550837725400925,
-0.018489403650164604,
-0.021219907328486443,
0.05554622784256935,
0.0186324305832386,
-0.05398593842983246,
0.0026833689771592617,
0.019529595971107483,
-0.022455133497714996,
0.061371300369501114,
0.017150158062577248,
-0.023495325818657875,
0.07239732891321182,
0.008555575273931026,
-0.052191607654094696,
-0.028657276183366776,
0.0003990109544247389,
0.000259844702668488,
0.008386543951928616,
-0.037524908781051636,
0.03339014947414398,
0.025913771241903305,
0.0000495208369102329,
0.008919642306864262,
-0.033806223422288895,
0.05731455236673355,
-0.04288189485669136,
0.009472244419157505,
-0.04350601136684418,
0.043844074010849,
-0.02675892598927021,
0.007970467209815979,
-0.02384638972580433,
-0.023417310789227486,
0.01691611483693123,
-0.013327454216778278,
-0.005935593042522669,
-0.05263369157910347,
0.03482041135430336,
-0.010258888825774193,
-0.0015074650291353464,
0.00954375695437193,
0.012540808878839016,
-0.009439738467335701,
-0.03531450033187866,
-0.015082776546478271,
-0.002759758150205016,
-0.0038877157494425774,
-0.013912561349570751,
-0.012027214281260967,
0.019009500741958618,
0.08722005784511566,
-0.04829088971018791,
-0.021154895424842834,
-0.03362419083714485,
0.008087488822638988,
0.025367669761180878,
-0.026550889015197754,
-0.03313009813427925,
0.004287539515644312,
-0.017306186258792877,
-0.029125362634658813,
-0.0007850195397622883,
-0.01846339926123619,
-0.018333375453948975,
-0.0012140985345467925,
0.0443381629884243,
-0.06345168501138687,
0.00943323690444231,
-0.009173189289867878,
-0.05320579558610916,
-0.07874249666929245,
-0.03344215825200081,
-0.02515963278710842,
0.007333350367844105,
-0.012144235894083977,
-0.012956885620951653,
-0.001331932726316154,
-0.009186191484332085,
-0.006026609800755978,
0.022858208045363426,
0.013912561349570751,
-0.03708282858133316,
-0.029307395219802856,
0.03419629484415054,
-0.01700713112950325,
0.01789129339158535,
-0.03742089122533798,
-0.024535518139600754,
-0.03999536484479904,
0.017839284613728523,
0.03573057800531387,
0.001763449632562697,
0.017293183133006096,
-0.024626534432172775,
0.03289605677127838,
0.01112354826182127,
0.00073057203553617,
-0.022182084619998932,
0.008119994774460793,
0.004381806589663029,
-0.020114703103899956,
0.009062668308615685,
-0.03326012194156647,
0.02176600694656372,
-0.005064432509243488,
-0.0004985605482943356,
-0.029229382053017616,
0.03843507543206215,
0.04319395124912262,
-0.012911377474665642,
0.02346932142972946,
-0.02417145110666752,
-0.03484641760587692,
-0.043818067759275436,
-0.0317518450319767,
0.07338551431894302,
0.007541388273239136,
0.020751820877194405,
-0.03185586631298065,
0.021063879132270813,
-0.012215749360620975,
0.012066221795976162,
-0.05294574797153473,
0.033078089356422424,
0.048004839569330215,
-0.05773063004016876,
0.0018950989469885826,
-0.003978732507675886,
0.01830737106502056,
0.05877082049846649,
0.007749426644295454,
-0.020179715007543564,
-0.025406677275896072,
-0.030607635155320168,
-0.04358402639627457,
0.01051243580877781,
0.0780663713812828,
-0.03221993148326874,
-0.0038877157494425774,
-0.016877107322216034,
0.026303842663764954,
-0.021557969972491264,
-0.05705450475215912,
0.009647776372730732,
-0.012072722427546978,
-0.09351322054862976,
-0.0007894891314208508,
-0.04298591613769531,
0.020569786429405212,
0.0403074212372303,
-0.029385410249233246,
0.007515383884310722,
-0.0076454076915979385,
0.04007337987422943,
0.05055330693721771,
-0.01902250200510025,
-0.0002671585534699261,
-0.004375305492430925,
0.00029336652369238436,
0.011143052019178867,
-0.016877107322216034,
-0.030243568122386932,
-0.05143747106194496,
0.031075721606612206,
-0.012436789460480213,
0.010070353746414185,
-0.017683256417512894,
0.03435232490301132,
0.04007337987422943,
0.00553902005776763,
0.032610002905130386,
0.017527226358652115,
-0.025744739919900894,
0.03513246774673462,
0.020751820877194405,
0.021466951817274094,
0.0004154671332798898,
0.023248281329870224,
-0.008835126645863056,
-0.02272818423807621,
0.054922111332416534,
-0.03612064942717552,
-0.03570457547903061,
0.022065062075853348,
0.0075673931278288364,
-0.0069237747229635715,
0.008529570885002613,
0.004544336814433336,
0.007385359611362219,
-0.009179689921438694,
-0.031647827476263046,
-0.027044979855418205,
-0.034924428910017014,
-0.0022526646498590708,
0.008119994774460793,
-0.032688017934560776,
-0.05151548609137535,
0.017124153673648834,
-0.017618244513869286,
0.035262491554021835,
-0.03996935859322548,
-0.016825098544359207,
0.0020495024509727955,
0.04126959666609764,
0.021740002557635307,
-0.06001904979348183,
0.03885115310549736,
0.059446945786476135,
0.026238830760121346,
-0.013216933235526085,
-0.015329822897911072,
0.02006269432604313,
-0.0124107850715518,
-0.0061826384626328945,
0.028995338827371597,
-0.05185354873538017,
0.0352884978055954,
-0.03362419083714485,
-0.03838306665420532,
-0.024691546335816383,
-0.013353458605706692,
-0.013281945139169693,
0.036484718322753906,
-0.033650197088718414,
-0.0049571627750992775,
-0.011266574263572693,
0.00553902005776763,
-0.024119440466165543,
0.04756275564432144,
-0.028007157146930695,
0.05939493700861931,
0.00010020985791925341,
-0.003322111675515771,
-0.0410875640809536,
-0.017514225095510483,
-0.03827904909849167,
-0.0005871393368579447,
0.013782537542283535,
0.004762126598507166,
0.026537885889410973,
-0.06204742565751076,
0.03398825600743294,
-0.004258283879607916,
0.0052399649284780025,
0.00755439093336463,
0.033078089356422424,
-0.011201562359929085,
0.014822728931903839,
0.00013591564493253827,
-0.025588711723685265,
-0.004947410896420479,
0.011468111537396908,
0.019152525812387466,
0.039865341037511826,
0.010804989375174046,
-0.03266201540827751,
0.008893637917935848,
0.02691495604813099,
0.017930300906300545,
0.04020340368151665,
-0.02725301682949066,
0.0102718910202384,
-0.00331398518756032,
0.08862432092428207,
-0.010896006599068642,
-0.030893687158823013,
-0.010870001278817654,
-0.02941141463816166,
0.00636792229488492,
-0.009485246613621712,
-0.0006472754175774753,
0.016422023996710777,
-0.010830993764102459,
0.012189744040369987,
0.03557455167174339,
0.00350739574059844,
0.04730270802974701,
-0.011344588361680508,
0.026173818856477737,
-0.03214191645383835,
-0.0038844652008265257,
-0.035678569227457047,
0.015225803479552269,
0.015329822897911072,
0.01414660457521677,
0.005483759567141533,
-0.08680398017168045,
0.029619453474879265,
0.016135970130562782,
-0.02564072050154209,
0.020257730036973953,
-0.034456342458724976,
0.003754441160708666,
0.02795514650642872,
0.02717500366270542,
0.05601431429386139,
0.03731686994433403,
0.05341383442282677,
-0.044364169239997864,
-0.02144094742834568,
-0.024223459884524345,
-0.027825122699141502,
0.02176600694656372,
-0.02733103185892105,
0.027747109532356262,
-0.027851127088069916,
0.007372357416898012,
-0.002980798715725541,
0.01184518076479435,
0.017267178744077682,
0.03580859303474426,
0.009855814278125763,
0.015914930030703545,
-0.018814463168382645,
-0.06678029894828796,
0.03385823220014572,
0.01564187929034233,
0.033728208392858505,
0.025497695431113243,
-0.03440433368086815,
0.004885649308562279,
-0.04504029452800751,
0.006611717399209738,
0.01981564797461033,
0.040255412459373474,
-0.00477512925863266,
0.03554854542016983,
-0.03521048277616501,
0.027122993022203445,
0.033494167029857635,
-0.01837238296866417,
-0.015745898708701134,
-0.02539367601275444,
0.016656067222356796,
-0.0352884978055954,
-0.0045053292997181416,
-0.07260537147521973,
0.0183853842318058,
-0.04241380840539932,
0.005317979026585817,
0.01845039613544941,
-0.018281366676092148,
-0.009478745050728321,
0.0082565201446414,
0.032688017934560776,
-0.035756584256887436,
-0.02894332818686962,
0.00039697933243587613,
-0.03609464690089226,
-0.05778263881802559,
-0.02925538644194603,
0.0362766794860363,
-0.040749501436948776,
0.010096359066665173,
0.04246581718325615,
-0.04972115531563759,
-0.0002220565074821934,
0.01027839258313179,
0.019477585330605507,
-0.03476840257644653,
0.005243215244263411,
0.005028675775974989,
-0.005708050914108753,
0.03640670329332352,
0.03827904909849167,
-0.03385823220014572,
0.027279023081064224,
0.03788897767663002,
-0.03094569779932499,
-0.03133577108383179,
0.0021502708550542593,
0.04199773073196411,
-0.006332166027277708,
0.05198357254266739,
0.028163185343146324,
-0.005347234662622213,
0.03765493258833885,
0.0014164482709020376,
0.0025858511216938496,
0.0008012725156731904,
-0.03198589012026787,
0.008276023901998997,
0.026251833885908127,
0.03359818458557129,
-0.01112354826182127,
-0.03159581869840622,
-0.01447166409343481,
0.017462214455008507,
-0.0039494773373007774,
-0.030191559344530106,
0.049461107701063156,
-0.013808541931211948,
0.005204208195209503,
-0.05104739964008331,
0.016018949449062347,
-0.027903137728571892,
-0.015004762448370457,
-0.018580421805381775,
-0.0012205997481942177,
0.021258914843201637,
0.03796698898077011,
0.0032603503204882145,
0.04829088971018791,
0.023807384073734283,
-0.025653723627328873,
0.0536738820374012,
-0.011351089924573898,
0.027044979855418205,
0.007502381224185228,
-0.012111729942262173,
0.02015371061861515,
0.017150158062577248,
-0.04415613040328026,
-0.03339014947414398,
-0.05304976552724838,
-0.0007683602161705494,
-0.02878729999065399,
0.0006663727108389139,
-0.02483457326889038,
-0.04400010034441948,
-0.024041427299380302,
0.014458661898970604,
0.02193503826856613,
-0.0004595533537212759,
-0.03807101026177406,
-0.0707850307226181,
-0.06740441173315048,
-0.052191607654094696,
-0.0021665238309651613,
-0.010089857503771782,
0.002826395444571972,
0.05260768532752991,
0.018190348520874977,
-0.016174977645277977,
-0.045976463705301285,
0.03900718316435814,
-0.029879501089453697,
-0.025588711723685265,
0.0205437820404768,
-0.016226988285779953,
0.0327400267124176,
-0.019360564649105072,
-0.003409877885133028,
0.02933340147137642,
-0.015355827286839485,
-0.025003602728247643,
0.007749426644295454,
0.0194125734269619,
0.03344215825200081,
-0.002023497596383095,
0.013379462994635105,
-0.008334534242749214,
0.016968123614788055,
-0.034534357488155365,
-0.0051912060007452965,
-0.03398825600743294,
-0.029229382053017616,
-0.02547168917953968,
-0.040983546525239944,
-0.0023193019442260265,
0.007593397982418537,
-0.0325319878757,
-0.010505934245884418,
-0.0004729620704893023,
0.005340733099728823,
0.02553670108318329,
-0.036874789744615555,
0.04868096485733986,
-0.013483482412993908,
0.001916227862238884,
0.005334232002496719,
-0.0033903741277754307,
0.011526621878147125,
0.01620098203420639,
-0.03263600915670395,
0.02071281336247921,
-0.019880659878253937,
0.0054122465662658215,
-0.030737658962607384,
-0.009764797985553741,
-0.024379488080739975,
0.012599320150911808,
-0.04368804395198822,
0.014484667219221592,
-0.04899302124977112,
-0.039137206971645355,
-0.028579261153936386,
0.013086909428238869,
0.023885397240519524,
-0.021427946165204048,
0.01789129339158535,
0.011923194862902164,
-0.02209106646478176,
0.017306186258792877,
0.009134181775152683,
0.0006789687322452664,
-0.02675892598927021,
0.006715736351907253,
0.015758901834487915,
-0.017345193773508072,
-0.05304976552724838,
-0.04457220807671547,
-0.07125312089920044,
0.02740904688835144,
-0.005022174678742886,
-0.010739977471530437,
-0.0066377222537994385,
0.017839284613728523,
0.04540435969829559,
0.04176368936896324,
-0.012391281314194202,
-0.02795514650642872,
0.0038292049430310726,
0.01612296886742115,
-0.03177785128355026,
-0.026329847052693367,
0.018008315935730934,
-0.03814902529120445,
-0.049435101449489594,
-0.02304024249315262,
-0.010713973082602024,
0.005220461171120405,
0.0005144072347320616,
0.008321532048285007,
0.00043395490502007306,
0.012319767847657204,
-0.0028962832875549793,
-0.0007021292694844306,
0.018333375453948975,
-0.02272818423807621,
-0.023664357140660286,
0.042439814656972885,
0.013912561349570751,
-0.04361002892255783,
-0.008119994774460793,
0.017449213191866875,
-0.014692705124616623,
0.033650197088718414,
0.042283784598112106,
0.017267178744077682,
0.004651606548577547,
-0.055806275457143784,
0.03664074465632439,
0.0335201732814312,
-0.004732871428132057,
0.006722237449139357,
0.005454504396766424,
0.00955025851726532,
-0.015004762448370457,
-0.03281804174184799,
0.012319767847657204,
0.016070958226919174,
0.01224825531244278,
-0.01643502525985241,
0.030451606959104538,
0.012826861813664436,
0.03333813697099686,
0.04665258899331093,
-0.007801436353474855,
0.011578631587326527,
-0.01846339926123619,
0.00654670549556613,
-0.0035366511438041925,
0.016825098544359207,
0.0014814602909609675,
0.0038617108948528767,
-0.007060300093144178,
0.009784301742911339,
0.08181106299161911,
0.0061208768747746944,
0.010421418584883213,
0.002296547871083021,
-0.014822728931903839,
0.03918921574950218,
-0.017852287739515305,
0.006832757964730263,
-0.06282756477594376,
-0.0022705430164933205,
0.0051619503647089005,
0.019867658615112305,
-0.0023095502983778715,
-0.03749890252947807,
0.002795514650642872,
0.019841652363538742,
0.042361799627542496,
0.0340142622590065,
0.020205719396471977,
-0.01999768242239952,
-0.021648986265063286,
0.002914161654189229,
-0.018424391746520996,
0.0024330730084329844,
0.006273655220866203,
-0.013060905039310455,
0.033884238451719284,
0.0056625427678227425,
-0.023742372170090675,
-0.03404026851058006,
0.020088698714971542,
0.012235253117978573,
0.0157328974455595,
-0.045586392283439636,
0.030243568122386932,
-0.06313962489366531,
-0.013047901913523674,
-0.02821519412100315,
0.010778984986245632,
0.01933456026017666,
0.005591029301285744,
0.014744714833796024,
-0.018502406775951385,
-0.016591055318713188,
-0.025003602728247643,
0.004388308152556419,
0.008315030485391617,
0.05382991209626198,
-0.018281366676092148,
-0.005343983881175518,
-0.007456873077899218,
-0.010375910438597202,
-0.04803084209561348,
-0.023911401629447937,
0.02990550547838211,
0.00685226172208786,
-0.02489958517253399,
0.052503667771816254,
-0.021375935524702072,
-0.010336902923882008,
0.009036663919687271,
-0.03809701278805733,
-0.023495325818657875,
-0.003500894643366337,
-0.026732921600341797,
0.012027214281260967,
0.012865868397057056,
-0.027096988633275032,
-0.0290993582457304,
0.023586342111229897,
0.016747083514928818,
-0.037108831107616425,
-0.009920826181769371,
0.009049666114151478,
-0.02619982324540615,
0.023833388462662697,
0.012670832686126232,
-0.035418521612882614,
0.029151367023587227,
-0.037524908781051636,
0.010499432682991028,
0.011234068311750889,
-0.006741741206496954,
0.01610996574163437,
0.000698066025506705,
-0.032115913927555084,
0.023404309526085854,
0.00040083943167701364,
0.0016114842146635056,
-0.013405468314886093,
-0.0031091973651200533,
0.020036689937114716,
-0.005048179533332586,
-0.011981706134974957,
-0.007352853659540415,
0.010922010987997055,
-0.005799067672342062,
0.022195085883140564,
0.007638906594365835,
0.032688017934560776,
-0.015082776546478271,
-0.007235832046717405,
-0.021648986265063286,
-0.005103439558297396,
0.0093877287581563,
-0.002225034637376666,
-0.03078966960310936,
-0.01790429651737213,
-0.012709840200841427,
0.017709260806441307,
0.013795539736747742,
-0.024600530043244362,
-0.0005546333850361407,
-0.0013514363672584295,
-0.028579261153936386,
-0.025965780019760132,
-0.0008662844775244594,
-0.009979337453842163,
-0.04480624943971634,
-0.04085352271795273,
-0.02618682198226452,
0.02668091282248497,
-0.01595393754541874,
0.018190348520874977,
-0.01382154505699873,
0.038019001483917236,
0.026576893404126167,
-0.11296480149030685,
-0.020660804584622383,
-0.010005341842770576,
-0.01781328022480011,
0.0163700133562088,
0.013294948264956474,
-0.004430565517395735,
-0.037992995232343674,
0.007892453111708164,
-0.008211011998355389,
0.006085120607167482,
-0.012989391572773457,
0.0012433539377525449,
0.009381227195262909,
-0.013366460800170898,
-0.014354642480611801,
-0.04496227949857712,
-0.01765725016593933,
0.005656041204929352,
0.028267204761505127,
-0.005002670921385288,
0.027851127088069916,
-0.012794355861842632,
0.034924428910017014,
0.024678543210029602,
0.009946831502020359,
-0.023027239367365837,
0.02337830513715744,
-0.0030913192313164473,
-0.001810583402402699,
0.02756507508456707,
-0.0020657554268836975,
-0.030529620125889778,
0.03596462309360504,
0.002060879487544298,
-0.06693632155656815,
0.01893148571252823,
-0.018333375453948975,
-0.017124153673648834,
-0.002532216254621744,
0.02336530201137066,
-0.016968123614788055,
-0.005308227147907019,
-0.0026914954651147127,
-0.008796119131147861,
-0.007430868223309517,
-0.058146703988313675,
-0.0028328965418040752,
-0.02756507508456707,
-0.03232395276427269,
0.02207806520164013,
-0.021141892299056053,
-0.01991966739296913,
0.0023371803108602762,
-0.014302633702754974,
0.003614665474742651,
-0.016239989548921585,
-0.006328915245831013,
0.013509487733244896,
0.0047361222095787525,
-0.03448234871029854,
0.04498828202486038,
0.005269220098853111,
-0.02878729999065399,
0.017878292128443718,
-0.026251833885908127,
-0.0637117326259613,
0.019555600360035896,
-0.024808567017316818,
0.002346932189539075,
0.0011580256978049874,
0.029229382053017616,
-0.018957490101456642,
0.012365276925265789,
0.01733219064772129,
0.021401939913630486,
0.00729434285312891,
-0.014341640286147594,
0.016565049067139626,
0.030191559344530106,
-0.017852287739515305,
-0.026563890278339386,
-0.0070928060449659824,
-0.005483759567141533,
0.0020430011209100485,
-0.02200005017220974,
0.010974020697176456,
0.003047436010092497,
0.016487035900354385,
0.007008290383964777,
-0.019048506394028664,
-0.012924379669129848,
0.03063363954424858,
-0.01072047371417284,
0.014640695415437222,
0.008562076836824417,
-0.02144094742834568,
0.016252992674708366,
0.006696233060210943,
-0.017553232610225677,
0.04116557911038399,
-0.019373567774891853,
0.008315030485391617,
-0.012729343958199024,
-0.012358775362372398,
-0.006949779577553272,
0.03723885491490364,
0.0018154592253267765,
0.03658873587846756,
-0.027851127088069916,
0.036874789744615555,
-0.005656041204929352,
0.014575683511793613,
-0.003474889788776636,
0.01621398515999317,
-0.012157238088548183,
0.029567444697022438,
-0.022468136623501778,
0.010349906049668789,
0.004378556273877621,
0.01587592251598835,
-0.0019454831490293145,
-0.04015139117836952,
0.002623233012855053,
0.012196245603263378,
0.035340506583452225,
0.05094337835907936,
0.02643386647105217,
0.022832203656435013,
0.008503565564751625,
-0.021180899813771248,
0.01733219064772129,
0.008230515755712986,
0.003751190612092614,
-0.0014465163694694638,
0.03258400037884712,
0.0029677965212613344,
0.029229382053017616,
-0.010486430488526821,
0.04085352271795273,
-0.021713998168706894,
-0.0259527787566185,
-0.029775481671094894,
0.003647171426564455,
-0.004095754120498896,
0.002307924907654524,
-0.035262491554021835,
-0.0076129017397761345,
-0.028969334438443184,
0.006523950956761837,
-0.05715852230787277,
-0.002012120559811592,
0.06480392813682556,
0.010421418584883213,
0.019685624167323112,
0.03635469451546669,
0.0014960879925638437,
-0.03846108168363571,
-0.0025614716578274965,
0.018996497616171837,
0.005158699583262205,
0.05689847469329834,
-0.02941141463816166,
-0.02990550547838211,
0.028423232957720757,
0.004118508193641901,
-0.030451606959104538,
-0.026940960437059402,
0.006163134705275297,
0.012748847715556622,
0.01860642619431019,
-0.0896645113825798,
0.04321995750069618,
0.02088184468448162,
-0.0403074212372303,
-0.0031563311349600554,
0.03370220586657524,
-0.004612599033862352,
0.028475243598222733,
0.02717500366270542,
-0.03466438129544258,
-0.01257981639355421,
0.006741741206496954,
0.05281572416424751,
0.0059160892851650715,
-0.025523699820041656,
0.023989416658878326,
-0.005074184387922287,
0.0017894544871523976,
-0.011585133150219917,
-0.011136550456285477,
-0.0163700133562088,
0.010167872533202171,
0.03643270954489708,
0.024639535695314407,
0.005148948170244694,
-0.032349955290555954,
0.014978758059442043,
-0.03996935859322548,
-0.006569459568709135,
-0.015342825092375278,
0.03817502781748772,
0.0345083549618721,
-0.0308676827698946,
-0.018996497616171837,
-0.0004489889251999557,
0.03934524580836296,
-0.024964597076177597,
-0.03117974102497101,
0.027773113921284676,
0.018242359161376953,
0.027018975466489792,
-0.008958649821579456,
0.014198614284396172,
0.0029856746550649405,
-0.0014505796134471893,
-0.012105228379368782,
0.014523673802614212,
-0.00457684276625514,
-0.01893148571252823,
-0.03684878349304199,
-0.0420757457613945,
0.02787713333964348,
-0.0016057956963777542,
-0.01765725016593933,
-0.030269572511315346,
0.03159581869840622,
0.018970493227243423,
-0.04587244614958763,
0.020686808973550797,
-0.023794380947947502,
0.021089883521199226,
-0.002572848694398999,
-0.027279023081064224,
0.011539625003933907,
-0.020517777651548386,
-0.00870510283857584,
-0.01733219064772129,
0.014562681317329407,
-0.005961597431451082,
0.017072143033146858,
-0.0010865125805139542,
-0.027851127088069916,
-0.019789643585681915,
-0.022923219949007034,
0.00006988786481088027,
0.025653723627328873,
-0.01100652664899826,
0.002818268956616521,
0.01224825531244278,
0.003157956525683403,
0.008165503852069378,
-0.0004969352157786489,
0.013886556960642338,
0.04657457396388054,
-0.016174977645277977,
-0.0033513670787215233,
-0.007762429304420948,
0.025692731142044067,
0.014172608964145184,
0.004817387089133263,
-0.015914930030703545,
0.014926748350262642,
-0.034534357488155365,
0.0011588383931666613,
-0.016135970130562782,
0.0019292301731184125,
-0.01981564797461033,
-0.00040327737224288285,
0.014328638091683388,
0.030087539926171303,
0.012488799169659615,
0.0033611187245696783,
0.007404863368719816,
0.026706917211413383,
0.005990853067487478,
0.027201008051633835,
-0.004287539515644312,
-0.0268369410187006,
-0.011669648811221123,
-0.0051359455101192,
-0.010206879116594791,
-0.025354668498039246,
0.009465742856264114,
0.03167383000254631,
-0.005272470880299807,
0.0036959305871278048,
0.006549955811351538,
0.01111704669892788,
-0.03385823220014572,
-0.004742623306810856,
-0.0035691570956259966,
-0.011468111537396908,
0.006475192029029131,
-0.00012931287346873432,
-0.026134811341762543,
-0.024548519402742386,
-0.008926143869757652,
0.0038454579189419746,
-0.004703615792095661,
0.009121179580688477,
0.010922010987997055,
0.004258283879607916,
-0.058874838054180145,
0.009556759148836136,
-0.02094685658812523,
-0.021818017587065697,
-0.03713483735918999,
0.032115913927555084,
0.007365856319665909,
-0.03713483735918999,
-0.0066247195936739445,
0.02160997875034809,
-0.013340456411242485,
0.035340506583452225,
0.00842555146664381,
-0.0166170597076416,
0.018645433709025383,
-0.0017520725959911942,
-0.027435051277279854,
-0.006601965520530939,
-0.009244701825082302,
0.018905481323599815,
-0.016968123614788055,
-0.009212195873260498,
0.023079250007867813,
-0.008789618499577045,
-0.009251203387975693,
0.0054772584699094296,
-0.003517147619277239,
0.024054428562521935,
0.0021827768068760633,
-0.004099004901945591,
0.004466322250664234,
0.007736424449831247,
0.014939750544726849,
-0.0013620008248835802,
-0.001632613129913807,
-0.022689176723361015,
0.006878266576677561,
0.015992945060133934,
0.026381857693195343,
0.0066702282056212425,
0.018320372328162193,
0.03466438129544258,
-0.023573340848088264,
-0.025133628398180008,
-0.026940960437059402,
-0.041295602917671204,
-0.030269572511315346,
0.07073302567005157,
-0.02497759833931923,
-0.0017488219309598207,
0.04696464538574219,
-0.005838074721395969,
0.006315913051366806,
-0.016565049067139626,
0.043558020144701004,
-0.01402958296239376,
0.005382990930229425,
-0.02175300568342209,
0.023638352751731873,
0.03580859303474426,
-0.003377371933311224,
-0.0005647914949804544,
0.009140683338046074,
-0.038253042846918106,
-0.005636537913233042,
-0.009491747245192528,
0.017748268321156502,
0.01596694067120552,
-0.006910772528499365,
0.007469875272363424,
0.004879148211330175,
0.020179715007543564,
0.010700969956815243,
0.036380697041749954,
0.03989134356379509,
-0.014159606769680977,
0.045976463705301285,
-0.0008922892739064991,
-0.004612599033862352,
-0.05471407249569893,
-0.03310409560799599,
-0.002566347597166896,
-0.007307345513254404,
-0.004622350912541151,
-0.019854655489325523,
0.009231699630618095,
-0.02072581648826599,
-0.015238805674016476,
-0.0016951870638877153,
0.015134786255657673,
0.004164016805589199,
-0.015173793770372868,
-0.007021292578428984,
0.004710117354989052,
0.014445659704506397,
-0.0016342384042218328,
0.0026996219530701637,
-0.018099332228302956,
-0.02967146225273609,
0.029541438445448875,
-0.010870001278817654,
0.008165503852069378,
0.01999768242239952,
0.0033741211518645287,
-0.013639511540532112,
0.007762429304420948,
-0.018658434972167015,
-0.019880659878253937,
0.0026459870859980583,
-0.050995390862226486,
0.011578631587326527,
-0.02837122417986393,
-0.0028865314088761806,
-0.001739070168696344,
-0.006192390341311693,
-0.002517588436603546,
-0.03078966960310936,
-0.013912561349570751,
0.0006098935264162719,
-0.015329822897911072,
0.0018820965196937323,
-0.03247997909784317,
-0.011936197988688946,
0.017995312809944153,
0.005044928751885891,
-0.06558407843112946,
0.03409227728843689,
0.010336902923882008,
-0.0002567972696851939,
0.005379740614444017,
-0.011208063922822475,
-0.02925538644194603,
0.023157263174653053,
-0.008490563370287418,
0.012033715844154358,
-0.015862921252846718,
0.02021872252225876,
0.015251807868480682,
-0.007937961257994175,
0.05435000732541084,
0.008640090934932232,
0.020348746329545975,
-0.02651188150048256,
0.01314542070031166,
0.01699412800371647,
0.013164923526346684,
-0.005906337406486273,
0.0056625427678227425,
0.039683304727077484,
-0.010824493132531643,
-0.04849892854690552,
0.01157213095575571,
-0.00654670549556613,
-0.03632868826389313,
-0.012118231505155563,
0.01668207161128521,
0.015407836996018887,
-0.018957490101456642,
0.002776011126115918,
-0.016786091029644012,
0.02030973881483078,
-0.023274285718798637,
0.009855814278125763,
-0.015836915001273155,
-0.022299105301499367,
-0.0352884978055954,
-0.00031733966898173094,
0.007034295238554478,
0.0024460754357278347,
0.02522464469075203,
-0.02150595933198929,
0.030997706577181816,
-0.00713181309401989,
0.02644686959683895,
0.0004892150755040348,
-0.0023193019442260265,
0.02151896245777607,
-0.017267178744077682,
0.009485246613621712,
-0.007710419595241547,
-0.0004558964283205569,
0.0064524379558861256,
0.04264785349369049,
-0.017917299643158913,
0.01691611483693123,
0.0027646340895444155,
0.020036689937114716,
-0.0012010961072519422,
-0.013028399087488651,
-0.005324480123817921,
-0.013268942944705486,
0.019802646711468697,
-0.0002671585534699261,
0.002306299516931176,
-0.018645433709025383,
0.013964571058750153,
-0.01587592251598835,
0.0012904875911772251,
-0.007489379029721022,
0.03536651283502579,
-0.013795539736747742,
0.003247347893193364,
-0.007385359611362219,
-0.030815673992037773,
-0.026303842663764954,
0.001274234615266323,
0.027773113921284676,
-0.02136293239891529,
-0.01124056987464428,
-0.04522232711315155,
0.015979941934347153,
0.013392466120421886,
0.0027240016497671604,
-0.016591055318713188,
0.014484667219221592,
-0.00785344559699297,
-0.0023111754562705755,
-0.001501776510849595,
0.013847549445927143,
0.024678543210029602,
-0.00830202829092741,
-0.01466670073568821,
0.004664608743041754,
0.015147789381444454,
0.025185637176036835,
-0.04826488718390465,
0.019958674907684326,
0.035262491554021835,
-0.044858258217573166,
0.016018949449062347,
-0.016487035900354385,
-0.015823913738131523,
0.005096938461065292,
0.0050059217028319836,
-0.012423787266016006,
0.0038454579189419746,
0.006504447665065527,
-0.038721129298210144,
0.013073907233774662,
0.03721285238862038,
0.0225591529160738,
0.0167600866407156,
0.04990318790078163,
0.021896030753850937,
-0.01860642619431019,
0.011552627198398113,
0.034950435161590576,
0.011949200183153152,
-0.025406677275896072,
0.013678518123924732,
0.012924379669129848,
-0.023755373433232307,
-0.03926723077893257,
-0.005951846018433571,
0.015173793770372868,
-0.006787249818444252,
-0.01973763480782509,
0.015251807868480682,
0.014952752739191055,
0.043167948722839355,
0.035678569227457047,
-0.006517449859529734,
-0.00048027592129074037,
-0.01560287270694971,
0.0031449540983885527,
-0.004099004901945591,
0.013717525638639927,
-0.010408416390419006,
-0.0012880496215075254,
-0.011936197988688946,
-0.002324177883565426,
0.015004762448370457,
0.016331007704138756,
0.0033481165301054716,
-0.01869744248688221,
0.020816832780838013,
0.000048047910240711644,
-0.0076129017397761345,
0.02618682198226452,
-0.01309341099113226,
0.01878845877945423,
0.0023371803108602762,
-0.027695098891854286,
-0.05648240074515343,
0.021635983139276505,
-0.010752979665994644,
0.009803805500268936,
-0.043896082788705826,
0.015017764642834663,
0.01313891913741827,
-0.014614691026508808,
0.006767746061086655,
0.002069005975499749,
-0.016500037163496017,
-0.040021367371082306,
-0.03289605677127838,
-0.008458057418465614,
-0.03136177361011505,
0.01618798077106476,
-0.009238201193511486,
-0.0002236818108940497,
-0.017462214455008507,
0.006975784432142973,
0.02925538644194603,
-0.03440433368086815,
-0.018671438097953796,
0.024288471788167953,
-0.020933853462338448,
-0.007222829852253199,
-0.021414943039417267,
0.011481113731861115,
0.0047231195494532585,
0.016708076000213623,
-0.05039728060364723,
0.0008614085963927209,
0.008731107227504253,
-0.0018479652935639024,
0.012300265021622181,
0.04467622563242912,
-0.05039728060364723,
0.019074512645602226,
0.010980521328747272,
-0.025172634050250053,
-0.005548771470785141,
-0.014653697609901428,
0.03409227728843689,
-0.009095174260437489,
0.024080432951450348,
0.02175300568342209,
-0.028319213539361954,
-0.029879501089453697,
0.013242938555777073,
-0.008289026096463203,
-0.01668207161128521,
0.01958160474896431,
-0.03359818458557129,
0.01692911610007286,
-0.010382412001490593,
0.006065616849809885,
0.01789129339158535,
-0.0034683886915445328,
-0.015355827286839485,
0.019633615389466286,
0.0056950487196445465,
-0.019464584067463875,
0.025822754949331284,
-0.009017160162329674,
0.00499942060559988,
0.024873578920960426,
-0.019490588456392288,
-0.0030880686827003956,
0.015823913738131523,
0.011656646616756916,
-0.007996472530066967,
0.03653672710061073,
0.009849313646554947,
0.015524858608841896,
0.02015371061861515,
-0.002290046541020274,
-0.008841628208756447,
0.0290993582457304,
0.025211641564965248,
-0.02868328057229519,
0.033416152000427246,
0.011058536358177662,
-0.007658409886062145,
-0.015420839190483093,
-0.02449651062488556,
-0.006224896293133497,
-0.0023745622020214796,
0.006774247158318758,
0.09580163657665253,
-0.01998467929661274,
-0.01798231154680252,
0.0031238251831382513,
-0.00903016235679388,
-0.004394809249788523,
0.021661987528204918,
-0.004654856864362955,
-0.012800856493413448,
-0.0187754575163126,
0.026134811341762543,
0.02435348369181156,
0.00975829642266035,
-0.003393624909222126,
-0.008354038000106812,
-0.020244726911187172,
-0.02088184468448162,
0.03781096264719963,
0.021818017587065697,
0.00769741740077734,
-0.002290046541020274,
0.03339014947414398,
-0.004401310347020626,
0.013886556960642338,
-0.014770719222724438,
0.0017650750232860446,
0.00003103305789409205,
0.00040327737224288285,
-0.023794380947947502,
0.0039657303132116795,
0.03237596154212952,
0.005578027106821537,
0.006676729302853346,
-0.03055562637746334,
-0.005841325502842665,
-0.0007529198774136603,
-0.025575708597898483,
-0.018073327839374542,
0.016148973256349564,
0.020491773262619972,
0.012352274730801582,
-0.020101701840758324,
-0.020998865365982056,
0.026420865207910538,
0.024132443591952324,
0.018268363550305367,
-0.023196270689368248,
-0.01588892564177513,
0.025822754949331284,
0.009816807694733143,
-0.011136550456285477,
-0.010356406681239605,
0.006839259061962366,
0.01438064780086279,
-0.0024785813875496387,
-0.02007569558918476,
0.025601712986826897,
-0.00743736932054162,
-0.01023288443684578,
-0.02556270733475685,
-0.02925538644194603,
-0.004781630355864763,
0.03448234871029854,
0.011019528843462467,
0.019464584067463875
] | 2025-01-10 | 124 | 39792660 | [
"fast CART recovery",
"CART",
"lengthy CARIS",
"CARIS",
"persistent tumor control",
"CARIS membrane lipid rafts",
"mLRs",
"Chimeric antigen receptor T cells",
"serial killing",
"low target site density",
"induce rapid lysis",
"cooperative killing",
"CD28.ζ",
"molecular dynamics",
"leukemic blasts",
"CD28.ζ-CART",
"the CART immune synapse",
"robust expansion",
"gradual accumulation",
"brief highly lethal CARIS",
"tumor engagement, CD28.ζ-CAR molecules",
"lytic granules",
"differences",
"sensitivity",
"engineering",
"Fas",
"their tumor rejection kinetics",
"CD19",
"more adaptive effective cellular products",
"the microtubular organizing center"
] | [] | 0 | 10.1126/sciadv.adq8114 | [
"Gad",
"Morris",
"Godret-Miertschin",
"Montalvo",
"Kerr",
"Berger",
"Lee",
"Saadeldin",
"Abu-Arja",
"Xu",
"Vasileiou",
"Brock",
"Fousek",
"Sheha",
"Srinivasan",
"Li",
"Saeedi",
"R Levental",
"Leen",
"Mamonkin",
"Carisey",
"Varadarajan",
"Hegde",
"Joseph",
"Levental",
"Mukherjee",
"Ahmed"
] | [
"Interdepartmental Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.\nTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Interdepartmental Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.\nTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"William A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77204, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.\nImmunology & Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nTexas Children's Hospital William T. Shearer Center for Human Immunobiology, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDevelopment, Disease Models & Therapeutics Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Interdepartmental Translational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.\nTexas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"William A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77204, USA.",
"William A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77204, USA.",
"Department of Molecular Physiology and Biological Physics, Center for Molecular and Cell Physiology, University of Virginia, Charlottesville, VA 22903, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.",
"Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nTexas Children's Hospital William T. Shearer Center for Human Immunobiology, Houston, TX 77030, USA.",
"William A. Brookshire Department of Chemical and Biomolecular Engineering, University of Houston, Houston, TX 77204, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.",
"Department of Molecular Physiology and Biological Physics, Center for Molecular and Cell Physiology, University of Virginia, Charlottesville, VA 22903, USA.",
"Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nTexas Children's Hospital William T. Shearer Center for Human Immunobiology, Houston, TX 77030, USA.",
"Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nCenter for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.\nDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.\nDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA."
] | [
"39792660",
"37059073",
"35650421",
"34088999",
"34230645",
"25319501",
"25317870",
"31650026",
"23515080",
"34560014",
"29385376",
"24553386",
"26333935",
"35110735",
"36750666",
"36912764",
"36202524",
"37055515",
"37890589",
"37971169",
"34971569",
"26514825",
"33795251",
"32193224",
"32728609",
"32045475",
"36849828",
"33002189",
"30190371",
"30848084",
"26129802",
"38134936",
"26330164",
"31477906",
"26330166",
"35490197",
"31852337",
"36867678",
"33649106",
"35418687",
"34878825",
"37715447",
"16818373",
"36598945",
"27265595",
"25367977",
"29440406",
"28663103",
"32004441",
"27427982",
"32632291",
"20498282",
"12218094",
"12419850",
"9924026",
"12021313",
"16203859",
"15322154",
"15494485",
"17060905",
"26982734",
"19177148",
"11376344",
"30084956",
"36097221",
"33771887",
"27111235",
"29769444",
"10477547",
"17325693",
"12515827",
"9585412",
"16878693",
"19060326",
"30131370",
"25939063",
"35452603",
"10480895",
"22129583",
"3109455",
"8104943",
"11792712",
"2477710",
"25666810",
"35213231",
"20679211",
"29079655",
"15099525",
"8985252",
"21602810",
"18835598",
"31270246",
"20534709",
"26461090",
"9464265",
"12391199",
"32234960",
"26885860",
"35881486",
"30936262",
"34471116",
"30918399",
"15699116",
"23091059",
"35914144",
"25955440",
"36520493",
"34381029",
"12526797",
"25711536",
"21964608",
"37228189",
"28978471",
"38307835",
"37500886",
"9348292",
"19349987",
"12799414",
"28699640",
"12562323",
"32205861",
"17575166",
"12517790",
"23407457"
] | [] | 7.731435 | 5.378867 |
39792088 | 48 | Cancer immunotherapy in progress-an overview of the past 130 years. | Since the first approval of an immune-checkpoint inhibitor, we have witnessed the clinical success of cancer immunotherapy. Adoptive T-cell therapy with chimeric antigen-receptor T (CAR-T) cells has shown remarkable efficacy in hematological malignancies. Concurrently with these successes, the cancer immunoediting concept that refined the cancer immunosurveillance concept underpinned the scientific mechanism and reason for past failures, as well as recent breakthroughs in cancer immunotherapy. Now, we face the next step of issues to be solved in this field, such as tumor heterogeneity, the tumor microenvironment, the metabolism of tumors and the immune system, and personalized approaches for patients, aiming to expand the population benefitted by the therapies. | [
0.009482025168836117,
-0.009968573227524757,
0.047296974807977676,
0.05657533183693886,
-0.03672870621085167,
-0.03743023797869682,
0.02017476223409176,
0.03625347092747688,
0.0005077635869383812,
0.01165451854467392,
0.035189855843782425,
-0.032315827906131744,
-0.06024141237139702,
0.0028542254585772753,
0.009957258589565754,
-0.013487558811903,
0.036230843514204025,
0.027676651254296303,
0.03935379907488823,
0.03537089750170708,
0.009340587072074413,
0.005501951090991497,
0.0002457491063978523,
-0.014834051951766014,
-0.04476240277290344,
-0.014675640501081944,
-0.03580087050795555,
0.0002432739274809137,
-0.0028556399047374725,
0.004294067621231079,
0.017391256988048553,
-0.018613284453749657,
-0.001960335299372673,
-0.000854994694236666,
-0.03652503341436386,
0.02638673409819603,
0.023354295641183853,
0.02625095285475254,
-0.02414635196328163,
-0.021419420838356018,
0.026431994512677193,
0.044422950595617294,
-0.002466684440150857,
0.09196885675191879,
-0.07037971168756485,
-0.04064371809363365,
-0.011230203323066235,
-0.06662310659885406,
-0.005742396228015423,
-0.029939664527773857,
-0.025368377566337585,
0.015727942809462547,
-0.033153142780065536,
0.06793566048145294,
-0.01917903684079647,
0.05453861877322197,
-0.021770186722278595,
0.022505667060613632,
-0.024191612377762794,
-0.003668910125270486,
0.043630894273519516,
-0.0033634034916758537,
0.010879436507821083,
-0.02482525445520878,
-0.058114178478717804,
0.0008535803062841296,
-0.029622843489050865,
-0.05177774280309677,
0.0007209818577393889,
0.011179285123944283,
0.02238120138645172,
-0.013555449433624744,
-0.008599449880421162,
0.005295450799167156,
0.047568537294864655,
-0.024372652173042297,
0.0003634965105447918,
0.01891878992319107,
-0.0038697526324540377,
-0.03426202014088631,
0.03530300781130791,
-0.01683681830763817,
0.02769928239285946,
-0.04118683934211731,
-0.01044380571693182,
0.009640436619520187,
0.031840596348047256,
-0.015297969803214073,
-0.07418157160282135,
-0.01735731214284897,
-0.02717878855764866,
0.04188837483525276,
-0.025617308914661407,
0.044671881943941116,
-0.0073491353541612625,
-0.014268298633396626,
-0.020333174616098404,
-0.07725927233695984,
0.042001526802778244,
0.025572050362825394,
0.06748305261135101,
0.0032445951364934444,
-0.021509941667318344,
-0.03272316977381706,
0.03254213184118271,
-0.0011194843100383878,
-0.046980153769254684,
-0.011269805952906609,
0.014528544619679451,
-0.014958517625927925,
-0.01080023031681776,
-0.025481529533863068,
-0.02303747460246086,
0.039059609174728394,
-0.041616812348365784,
-0.07182803750038147,
-0.03894645720720291,
-0.014189093373715878,
0.0073943957686424255,
0.021227063611149788,
-0.008672998286783695,
0.005156841594725847,
0.02239251509308815,
-0.009148230776190758,
0.03299473226070404,
-0.03516722470521927,
0.04937895014882088,
-0.02998492494225502,
-0.027654021978378296,
-0.043178293853998184,
0.024983666837215424,
-0.006013957783579826,
0.03308525308966637,
-0.007411368191242218,
-0.03489566221833229,
-0.022618817165493965,
-0.013464928604662418,
-0.027654021978378296,
-0.029554951936006546,
-0.00018493061361368746,
0.012559723109006882,
-0.014087256975471973,
-0.03030174784362316,
-0.011428216472268105,
-0.006138423457741737,
-0.05001259222626686,
0.019461913034319878,
0.027812432497739792,
0.02087629772722721,
0.03700026497244835,
-0.0274956114590168,
0.031003281474113464,
0.058431003242731094,
0.009623464196920395,
-0.013736490160226822,
0.005838573910295963,
0.013532819226384163,
0.06426957249641418,
-0.02808399498462677,
-0.026477254927158356,
-0.04182048514485359,
0.0015275339828804135,
-0.01037591602653265,
-0.03847122564911842,
0.028038734570145607,
-0.030618568882346153,
-0.012887860648334026,
0.019473228603601456,
-0.03147851303219795,
-0.005216245539486408,
-0.026137802749872208,
-0.032044269144535065,
-0.028106624260544777,
-0.010681422427296638,
-0.016395531594753265,
0.01521876361221075,
-0.0018457701662555337,
0.03213478624820709,
-0.013453613966703415,
-0.018692489713430405,
-0.016904707998037338,
0.0068060122430324554,
0.0484284833073616,
0.013872271403670311,
-0.007620696909725666,
0.026499884203076363,
0.0021102598402649164,
0.015467695891857147,
-0.05277346819639206,
-0.040032703429460526,
-0.006132765673100948,
-0.006455245427787304,
0.024915775284171104,
0.004361957777291536,
0.00042325418326072395,
-0.006947450805455446,
0.027857692912220955,
0.028129255399107933,
-0.010138299316167831,
-0.023739008232951164,
0.02860448695719242,
-0.013600709848105907,
-0.03862963616847992,
0.006047903094440699,
-0.02552678994834423,
-0.04032689705491066,
-0.03215741738677025,
0.027314569801092148,
-0.006415642332285643,
0.019541120156645775,
0.023806899785995483,
0.002659040503203869,
0.010556956753134727,
0.04313303157687187,
-0.025368377566337585,
-0.020005036145448685,
-0.014845366589725018,
0.021238379180431366,
0.013691229745745659,
0.06522004306316376,
-0.01793438009917736,
0.01826251670718193,
0.02120443433523178,
0.0033464308362454176,
-0.042838841676712036,
-0.00828262884169817,
0.015875037759542465,
-0.013374407775700092,
-0.015196133404970169,
-0.0075980667024850845,
-0.023150624707341194,
0.016655776649713516,
0.014947202056646347,
-0.010081724263727665,
-0.057254236191511154,
-0.006132765673100948,
0.03143325448036194,
-0.0076829297468066216,
0.03195374831557274,
-0.01714232563972473,
0.026069913059473038,
0.02382952906191349,
0.0028414959087967873,
-0.025775721296668053,
-0.04308777302503586,
0.007032313849776983,
0.007609381806105375,
-0.055760644376277924,
0.0032898555509746075,
0.010523011907935143,
-0.013329148292541504,
0.024893146008253098,
0.008791806176304817,
-0.014551174826920033,
0.027676651254296303,
0.0035189855843782425,
0.07658036798238754,
-0.03881067782640457,
0.005026718135923147,
0.001851427718065679,
-0.00615539588034153,
0.015626106411218643,
-0.05965302884578705,
-0.03647977486252785,
-0.05956250801682472,
0.011665833182632923,
0.01740257255733013,
0.021102597936987877,
0.024055831134319305,
-0.018092790618538857,
0.02153257094323635,
0.03050541877746582,
0.022143583744764328,
-0.026069913059473038,
-0.042386237531900406,
0.03154640272259712,
-0.014573805034160614,
0.07169225811958313,
0.003578389761969447,
0.03317577391862869,
-0.03602717071771622,
-0.022505667060613632,
-0.0012920391745865345,
0.010432491078972816,
0.005255848169326782,
0.006064875517040491,
0.0005077635869383812,
-0.015139558352530003,
0.011071791872382164,
-0.022109638899564743,
0.009810162708163261,
-0.008548532612621784,
-0.022505667060613632,
0.021238379180431366,
-0.014788791537284851,
0.005193615332245827,
0.001304061384871602,
-0.023987939581274986,
-0.022211475297808647,
0.0377018004655838,
-0.01662183180451393,
-0.030528048053383827,
-0.033809415996074677,
-0.01812673546373844,
0.04652755334973335,
0.015015092678368092,
-0.022935638204216957,
-0.015546901151537895,
0.01688207872211933,
0.03752075880765915,
0.03437517210841179,
-0.021430734544992447,
0.022675393149256706,
0.03498618304729462,
0.01682550273835659,
0.020310543477535248,
0.044287167489528656,
-0.06612524390220642,
0.0137478057295084,
-0.024372652173042297,
-0.021758873015642166,
0.01139427162706852,
-0.024598954245448112,
0.030595939606428146,
-0.012548408471047878,
-0.010658792220056057,
0.01860196888446808,
-0.004602403379976749,
0.06531056016683578,
-0.03089013136923313,
-0.010070408694446087,
-0.03700026497244835,
0.04301988333463669,
-0.02128363959491253,
0.0014214551774784923,
-0.020061612129211426,
-0.03247423842549324,
-0.039829034358263016,
-0.000013193543964007404,
-0.011037847027182579,
-0.021713612601161003,
0.007569779176265001,
-0.06010563299059868,
0.04243149980902672,
0.044807661324739456,
-0.042522016912698746,
-0.012503148056566715,
0.03675133362412453,
0.0033379446249455214,
0.03661555424332619,
0.06359066814184189,
0.028853418305516243,
0.032112158834934235,
0.008061984553933144,
-0.028468705713748932,
0.0587930828332901,
-0.04707067459821701,
-0.023535337299108505,
0.017131010070443153,
-0.018104106187820435,
0.02296958491206169,
-0.013555449433624744,
-0.026273583993315697,
0.060920316725969315,
0.06626103073358536,
0.029803885146975517,
-0.04569023847579956,
0.013295202516019344,
-0.05924568697810173,
-0.0038810677360743284,
-0.02192859910428524,
0.008825751952826977,
0.015422435477375984,
0.009606490842998028,
-0.059471987187862396,
0.06037719175219536,
-0.0034171498846262693,
0.007801738101989031,
-0.0031003281474113464,
0.034148868173360825,
0.002606708323583007,
-0.004622204694896936,
0.0067268069833517075,
0.00012207895633764565,
-0.024055831134319305,
0.018579337745904922,
0.04406086727976799,
-0.027835063636302948,
-0.07807395607233047,
0.0007460871711373329,
-0.006166710983961821,
-0.03188585489988327,
0.020831037312746048,
0.007688587531447411,
0.002294129692018032,
0.07250694185495377,
-0.029215501621365547,
0.06512951850891113,
0.055217523127794266,
-0.00001727094604575541,
-0.013498874381184578,
-0.06585368514060974,
-0.020729200914502144,
-0.0430651418864727,
-0.02978125400841236,
-0.03188585489988327,
0.029419172555208206,
0.0071454644203186035,
0.06970080733299255,
-0.01152439508587122,
0.003114471910521388,
0.013962791301310062,
0.033877309411764145,
0.0012135407887399197,
0.0012708234135061502,
-0.04059845581650734,
-0.03758864849805832,
0.020412379875779152,
0.015433750115334988,
0.01289917528629303,
0.021690981462597847,
-0.01722153089940548,
0.0024921433068811893,
-0.012638929300010204,
0.004562800284475088,
0.002362020080909133,
0.055217523127794266,
-0.016848133876919746,
0.005804629065096378,
-0.046980153769254684,
-0.06454113870859146,
0.05978880822658539,
0.025028927251696587,
-0.01106047723442316,
-0.028265034779906273,
0.06426957249641418,
0.008101587183773518,
0.0049361977726221085,
-0.03684185445308685,
-0.006817327346652746,
-0.03729445859789848,
0.0012786025181412697,
0.006698518991470337,
-0.011439532041549683,
0.013306518085300922,
-0.0037169991992413998,
-0.0037594307214021683,
0.03991955518722534,
0.008661682717502117,
-0.022166214883327484,
0.012763394974172115,
-0.05684689059853554,
0.0029362596105784178,
0.02729193866252899,
-0.04623335972428322,
-0.028830789029598236,
0.002784920623525977,
-0.04360826313495636,
0.022901693359017372,
0.03919538855552673,
-0.010206189937889576,
-0.012876545079052448,
0.01741388626396656,
-0.01905457116663456,
0.01338572334498167,
0.06553686410188675,
0.025956761091947556,
0.020140817388892174,
-0.01093035377562046,
-0.025323117151856422,
0.016995228826999664,
-0.009182176552712917,
-0.004998430609703064,
-0.019269557669758797,
-0.015920298174023628,
0.024055831134319305,
-0.021317584440112114,
0.011377299204468727,
0.004772129002958536,
0.022041749209165573,
-0.030143335461616516,
-0.013487558811903,
-0.03475988283753395,
0.004378930665552616,
0.0330173633992672,
-0.017391256988048553,
-0.020978132262825966,
-0.01629369519650936,
-0.0059234369546175,
0.0002724455844145268,
0.014653010293841362,
-0.004265780095010996,
-0.01800226978957653,
-0.008757861331105232,
-0.027744542807340622,
0.0008875255007296801,
0.019280873239040375,
-0.007750820368528366,
-0.021623091772198677,
0.006161053664982319,
0.00032230259967036545,
0.025300487875938416,
0.003974416758865118,
0.03288158401846886,
0.04720645770430565,
0.03464673087000847,
0.022799858823418617,
0.0389011986553669,
0.03213478624820709,
0.012491833418607712,
-0.034533582627773285,
-0.02428213134407997,
0.049333687871694565,
-0.010313683189451694,
-0.022675393149256706,
-0.006161053664982319,
-0.029215501621365547,
-0.01805884577333927,
0.01689339429140091,
-0.00342846498824656,
-0.009589518420398235,
0.01727810688316822,
0.004709896165877581,
0.007484916131943464,
0.014313559047877789,
-0.02625095285475254,
-0.04163944348692894,
0.027676651254296303,
-0.03758864849805832,
-0.014121202751994133,
-0.002453954890370369,
-0.033899936825037,
-0.004859820939600468,
0.014596435241401196,
0.016282379627227783,
-0.009962915442883968,
-0.02821977436542511,
0.0309580210596323,
-0.022415146231651306,
-0.03704552724957466,
0.0002918933460023254,
0.0038442937657237053,
0.01655394211411476,
-0.007665957324206829,
-0.016316326335072517,
0.03962536156177521,
-0.01384964119642973,
-0.02769928239285946,
0.019744791090488434,
-0.01515087392181158,
-0.0029108007438480854,
-0.023535337299108505,
-0.00377357448451221,
0.015015092678368092,
0.022109638899564743,
0.006822984665632248,
-0.0235127080231905,
-0.018432242795825005,
-0.03319840505719185,
-0.011960024945437908,
-0.011688463389873505,
-0.01748177781701088,
-0.000030011444323463365,
-0.007552806753665209,
-0.016022134572267532,
0.030731718987226486,
-0.010760627686977386,
-0.010783257894217968,
-0.022754598408937454,
0.013657284900546074,
-0.006025272887200117,
0.018556708469986916,
-0.010777600109577179,
-0.025096816942095757,
0.03462410345673561,
0.022607501596212387,
-0.02514207735657692,
0.006540108472108841,
-0.016983915120363235,
0.022471722215414047,
-0.010291052982211113,
-0.009900682605803013,
-0.026069913059473038,
0.061508700251579285,
0.013091531582176685,
0.006721149198710918,
-0.032564759254455566,
-0.020253969356417656,
0.0006484947516582906,
0.0030890130437910557,
0.02455369383096695,
-0.004743841476738453,
0.02776717208325863,
-0.0005625709309242666,
-0.010534326545894146,
0.029373912140727043,
0.023874789476394653,
0.013408353552222252,
-0.0027948212809860706,
0.020604735240340233,
0.015750572085380554,
0.008786149322986603,
0.013238627463579178,
-0.0511893592774868,
-0.025888871401548386,
0.03333418443799019,
-0.010364600457251072,
-0.010947326198220253,
0.004769300576299429,
-0.006008299998939037,
0.043630894273519516,
-0.0029588898178189993,
-0.018036214634776115,
0.023942679166793823,
0.013883586041629314,
0.011416901834309101,
-0.019552433863282204,
0.004096054006367922,
0.020220022648572922,
-0.027201419696211815,
0.0037169991992413998,
0.004774957895278931,
-0.01358939427882433,
-0.013951476663351059,
-0.0121071208268404,
-0.042974621057510376,
-0.011711093597114086,
-0.0312974713742733,
0.03670607507228851,
-0.004277095198631287,
0.03374152630567551,
-0.03860700502991676,
-0.010998244397342205,
0.040304265916347504,
0.021193118765950203,
-0.03998744487762451,
0.04725171625614166,
-0.017889119684696198,
-0.006115793250501156,
0.016010819002985954,
0.002069242764264345,
0.0003290208987891674,
-0.017300736159086227,
0.004486423917114735,
0.02284511923789978,
-0.025888871401548386,
-0.024327391758561134,
-0.013962791301310062,
-0.0013139620423316956,
-0.015309284441173077,
-0.007948833517730236,
-0.0494694709777832,
0.01701785996556282,
-0.020446324720978737,
0.008209080435335636,
-0.013204682618379593,
0.011609258130192757,
-0.002763704862445593,
0.044671881943941116,
0.07246168702840805,
-0.014143832959234715,
-0.0005685820942744613,
0.025911500677466393,
-0.00929532665759325,
-0.019416652619838715,
0.013374407775700092,
-0.005889492109417915,
-0.0250741858035326,
0.009668723680078983,
0.005790485069155693,
0.049786292016506195,
-0.0015925955958664417,
0.003086184384301305,
-0.006749437190592289,
-0.011275463737547398,
0.010166587308049202,
0.006364724598824978,
-0.026364104822278023,
-0.012061860412359238,
-0.004271437413990498,
-0.021962543949484825,
0.015388489700853825,
-0.035914018750190735,
-0.043042510747909546,
0.0035897046327590942,
-0.0026576260570436716,
0.03700026497244835,
-0.00032707612263038754,
-0.01358939427882433,
-0.014256983064115047,
0.014981147833168507,
-0.005784827750176191,
-0.019484544172883034,
-0.014166463166475296,
-0.012887860648334026,
0.004658978432416916,
-0.008944559842348099,
0.0031031568069010973,
-0.042861469089984894,
-0.004104540217667818,
0.016746297478675842,
0.015116928145289421,
0.03362837806344032,
-0.0432235524058342,
0.018805639818310738,
0.006800354924052954,
-0.0014476212672889233,
-0.0038216635584831238,
0.02926076017320156,
-0.009204806759953499,
0.003456752747297287,
-0.01093035377562046,
0.01749309152364731,
-0.015207448974251747,
0.006166710983961821,
-0.0037000265438109636,
-0.022098323330283165,
0.018737750127911568,
0.010619189590215683,
-0.0020593421068042517,
0.01246920321136713,
-0.011835559271275997,
0.010438148863613605,
0.027902953326702118,
0.03170481696724892,
0.017832543700933456,
-0.03213478624820709,
0.0549912229180336,
-0.019552433863282204,
-0.0003512974362820387,
-0.02493840642273426,
-0.027902953326702118,
-0.021102597936987877,
-0.016599202528595924,
0.0029786911327391863,
0.04838322475552559,
-0.03638925403356552,
-0.056665852665901184,
-0.01871511898934841,
-0.00022506373352371156,
0.0018033386440947652,
-0.02423687092959881,
-0.012265531346201897,
0.016338955610990524,
0.001299818279221654,
0.030392266809940338,
0.022811172530055046,
-0.004158286843448877,
0.004378930665552616,
-0.025028927251696587,
0.01950717344880104,
0.0069700805470347404,
-0.025888871401548386,
-0.0250741858035326,
0.017696764320135117,
-0.026069913059473038,
0.01165451854467392,
0.01433618925511837,
-0.02344481647014618,
-0.030075445771217346,
-0.021385474130511284,
0.011201915331184864,
0.004067766480147839,
0.03050541877746582,
-0.0019447769736871123,
0.018884845077991486,
0.02358059771358967,
0.01964295469224453,
-0.029057089239358902,
0.010432491078972816,
0.0012177840108051896,
0.0008839895599521697,
0.01119060069322586,
-0.01805884577333927,
-0.011275463737547398,
0.014913257211446762,
-0.02423687092959881,
0.00789225846529007,
-0.025300487875938416,
0.015184818767011166,
0.004721211269497871,
0.0024200098123401403,
-0.03559719771146774,
0.002240383066236973,
-0.008107244968414307,
-0.011699778027832508,
0.010562614537775517,
0.02423687092959881,
-0.006579711101949215,
-0.027405090630054474,
-0.007813053205609322,
0.0017340339254587889,
-0.03091276064515114,
0.028559226542711258,
-0.015467695891857147,
0.039896924048662186,
0.04240886867046356,
-0.059155166149139404,
0.012887860648334026,
0.01860196888446808,
0.005176642909646034,
-0.011405586265027523,
-0.005759368650615215,
-0.03620821237564087,
0.0052699921652674675,
0.007880943827331066,
-0.017821229994297028,
0.0011329209664836526,
-0.03344733640551567,
0.017436517402529716,
-0.009487682953476906,
0.020717885345220566,
-0.0328589528799057,
-0.024078460410237312,
-0.0740005299448967,
-0.03279106318950653,
0.03557456657290459,
0.010110011324286461,
0.00530393747612834,
-0.02423687092959881,
0.03236109018325806,
-0.008882327005267143,
0.022630132734775543,
-0.02146468125283718,
0.0029956637881696224,
-0.038788046687841415,
-0.023354295641183853,
-0.022426461800932884,
0.017696764320135117,
-0.022607501596212387,
0.03084487095475197,
-0.003018293995410204,
-0.04433242976665497,
0.02311667986214161,
-0.012729449197649956,
-0.027970843017101288,
-0.008327888324856758,
-0.0188509002327919,
0.015286654233932495,
0.022403830662369728,
0.02455369383096695,
-0.03799599036574364,
-0.041548922657966614,
-0.021815447136759758,
-0.004593916703015566,
0.014845366589725018,
-0.012503148056566715,
0.0003488222719170153,
-0.02545889839529991,
-0.04234097898006439,
-0.003954615443944931,
0.011858189478516579,
-0.0008663097396492958,
-0.018149366602301598,
0.04578075930476189,
0.014686956070363522,
0.011354668997228146,
-0.04512448236346245,
0.04892634600400925,
0.04951472952961922,
0.00034917588345706463,
-0.010873778723180294,
0.007111519109457731,
-0.017979640513658524,
0.058431003242731094,
-0.018760379403829575,
0.004670293536037207,
0.013136791996657848,
0.005991327576339245,
-0.04987681284546852,
0.03288158401846886,
-0.005012574139982462,
-0.005589642561972141,
-0.010687080211937428,
-0.002584078349173069,
0.015795832499861717,
0.033221032470464706,
-0.037543389946222305,
-0.03089013136923313,
-0.013521503657102585,
0.020740516483783722,
-0.023150624707341194,
-0.024055831134319305,
-0.010539984330534935,
-0.002121574943885207,
0.016135284677147865,
-0.019925830885767937,
0.005117238499224186,
-0.03070908971130848,
0.010658792220056057,
0.02566256932914257,
0.011224545538425446,
-0.00652879336848855,
-0.018545392900705338,
-0.000012895197869511321,
0.0017891948809847236,
-0.004274266306310892,
0.04301988333463669,
-0.041594184935092926,
0.009402819909155369,
-0.0501483716070652,
-0.057978399097919464,
-0.009001134894788265,
0.007813053205609322,
-0.010760627686977386,
0.014290928840637207,
0.0073547931388020515,
0.009895025752484798,
-0.029554951936006546,
0.029803885146975517,
-0.020649995654821396,
0.006907847709953785,
-0.002857054118067026,
0.02389742061495781,
-0.01890747621655464,
0.025187337771058083,
-0.015535585582256317,
0.06304755061864853,
0.013645969331264496,
-0.010721025057137012,
-0.008537217043340206,
0.010081724263727665,
-0.007530176546424627,
0.008327888324856758,
0.0005664604832418263,
-0.0067664096131920815,
-0.005428403150290251,
0.03500881418585777,
-0.01450591441243887,
0.01899799518287182,
0.0036236499436199665,
-0.00906902551651001,
0.02330903708934784,
0.013170736841857433,
0.03281369060277939,
0.01808147504925728,
0.004950341302901506,
0.013182052411139011,
-0.03881067782640457,
-0.041096318513154984,
-0.004684437531977892,
0.04170733317732811,
-0.012197641655802727,
-0.04071160778403282,
0.012774709612131119,
0.016983915120363235,
0.006161053664982319,
-0.01852276362478733,
-0.003159732325002551,
0.04643703252077103,
0.0577520988881588,
-0.020808406174182892,
0.029102349653840065,
0.04870004579424858,
0.007654642220586538,
-0.011015216819941998,
0.029690733179450035,
-0.014981147833168507,
0.04064371809363365,
-0.028468705713748932,
-0.003340773284435272,
-0.0039121839217841625,
-0.004333670251071453,
0.005640560295432806,
0.0039772456511855125,
0.05440283939242363,
0.01644079200923443,
0.01440407894551754,
-0.055172260850667953,
0.028197145089507103,
-0.019473228603601456,
-0.035642459988594055,
0.04351774603128433,
0.010534326545894146,
0.009578203782439232,
0.01938270777463913,
0.008135532960295677,
-0.033153142780065536,
0.011733723804354668,
0.0024086947087198496,
0.051823001354932785,
0.05259242653846741,
-0.008854039013385773,
-0.008033696562051773,
-0.019292186945676804,
0.011552682146430016,
-0.012333421967923641,
-0.0037962046917527914,
-0.02808399498462677,
0.009674381464719772,
0.06218760460615158,
0.011450846679508686,
-0.028649747371673584,
-0.04937895014882088,
0.00884272437542677,
-0.049197908490896225,
-0.02324114553630352,
-0.08816699683666229,
0.03371889889240265,
0.020638680085539818,
-0.02009555697441101,
-0.00815250538289547,
0.013996737077832222,
0.017911748960614204,
-0.05806891992688179,
-0.020932871848344803,
0.008288285695016384,
-0.01945059932768345,
0.029577583074569702,
-0.018737750127911568,
0.028830789029598236,
0.012627613730728626,
0.004243149887770414,
0.02017476223409176,
0.0034454376436769962,
-0.021317584440112114,
0.005094608757644892,
-0.003097499255090952,
-0.032564759254455566,
-0.000046100056351860985,
-0.009770560078322887,
-0.032972101122140884,
0.03548404574394226,
0.04333670437335968,
0.009244409389793873,
-0.020310543477535248,
0.006432615220546722,
0.006194998510181904,
0.018160680308938026,
0.017300736159086227,
0.004687265958636999,
0.008005409501492977,
-0.00015708494174759835,
-0.003617992391809821,
-0.011184942908585072,
0.03960273042321205,
0.008197765797376633,
0.05702793225646019,
0.048156920820474625,
-0.006025272887200117,
-0.02815188467502594,
-0.00007991265738382936,
-0.0008691385155543685,
0.059743549674749374,
-0.028106624260544777,
-0.01801358535885811,
-0.03070908971130848,
-0.025028927251696587,
0.014743531122803688,
0.02880815789103508,
0.021328900009393692,
0.03618558123707771,
0.013645969331264496,
0.014800106175243855,
0.0012135407887399197,
0.013544133864343166,
0.021238379180431366,
0.02278854325413704,
-0.02735983021557331,
-0.004675951320677996,
-0.017900435253977776,
0.029306020587682724,
-0.0036915403325110674,
-0.007903574034571648,
-0.010392888449132442,
0.0174704622477293,
-0.0019179036607965827,
0.03403571993112564,
0.018828270956873894,
-0.011971339583396912,
-0.003504841821268201,
-0.00860510766506195,
-0.011824243701994419,
0.01976742036640644,
-0.002434153575450182,
-0.013600709848105907,
-0.003963102120906115,
-0.004856992047280073,
0.0035953621845692396,
0.02140810526907444,
-0.01177898421883583,
0.012050545774400234,
0.009725299663841724,
-0.017119694501161575,
-0.023987939581274986,
-0.005980012472718954,
0.01080023031681776,
-0.04351774603128433,
-0.0008825751719996333,
-0.018104106187820435,
-0.0019857941661030054,
0.003858437528833747,
-0.0345788411796093,
-0.011835559271275997,
0.01931481808423996,
-0.015049038454890251,
-0.03706815838813782,
0.003926327917724848,
0.03883330523967743,
-0.008288285695016384,
-0.02573046088218689,
-0.006941793020814657,
-0.001448328490369022,
-0.0344204306602478,
-0.030595939606428146,
0.04630124941468239,
0.0032615677919238806,
-0.05028415471315384,
0.02166835218667984,
0.04028163477778435,
0.00042183982441201806,
0.026545144617557526,
-0.025911500677466393,
-0.00594040984287858,
0.018217256292700768,
0.029441801831126213,
0.0020734858699142933,
-0.022301996126770973,
0.014415394514799118,
-0.026409365236759186,
-0.009951600804924965,
-0.03374152630567551,
-0.021181803196668625,
0.006211971398442984,
0.003343601943925023,
-0.01407594233751297,
-0.02304879017174244,
0.020050296559929848,
-0.020265283063054085,
0.010336313396692276,
-0.015546901151537895,
0.025481529533863068,
0.008158163167536259,
-0.0018245544051751494,
-0.017198899760842323,
0.022245420143008232,
0.009798847138881683,
-0.010817203670740128,
0.011903449892997742,
-0.0007623526034876704,
0.014415394514799118,
-0.005445375572890043,
-0.02344481647014618,
-0.011609258130192757,
-0.013397037982940674,
-0.031908486038446426,
-0.038991719484329224,
0.044490840286016464,
-0.03267791122198105,
-0.028989199548959732,
0.0333794467151165,
0.019280873239040375,
-0.030550679191946983,
0.015331914648413658,
0.01430224347859621,
0.015558215789496899,
-0.010030806064605713,
-0.0027905781753361225,
0.03815440461039543,
0.010387230664491653,
-0.026024652644991875,
-0.012095806188881397,
0.008576820604503155,
0.008820094168186188,
0.012616299092769623,
-0.007456628605723381,
-0.0066136559471488,
0.0007552806637249887,
0.027518240734934807,
-0.045260265469551086,
0.01234473753720522,
0.015818461775779724,
0.014947202056646347,
0.0532713308930397,
0.009674381464719772,
0.00651182048022747,
0.067075714468956,
0.002922115847468376,
0.014460654929280281,
-0.014958517625927925,
-0.00917086098343134,
0.024983666837215424,
-0.015015092678368092,
-0.049197908490896225,
-0.014279613271355629,
0.02094418741762638,
-0.016904707998037338,
0.008101587183773518,
0.0041271704249084,
0.0069757383316755295,
-0.026341473683714867,
-0.020333174616098404,
0.009334929287433624,
-0.02659040503203869,
0.007213354576379061,
-0.03804125264286995,
0.03849385678768158,
-0.03933117166161537,
-0.016768928617239,
0.019394023343920708,
0.005504779517650604,
0.003340773284435272,
0.03835807368159294,
0.000673953618388623,
0.047568537294864655,
0.00899547804147005,
0.02127232402563095,
-0.02061605080962181,
0.011563997715711594,
-0.04340459406375885,
0.023987939581274986,
-0.019948462024331093,
0.022550927475094795,
-0.0034312938805669546,
-0.019088516011834145,
-0.06132765859365463,
-0.011609258130192757,
0.009934628382325172,
-0.018092790618538857,
0.01584109291434288,
0.001182424370199442,
0.010177901946008205,
0.004557142965495586,
0.016123969107866287,
0.01924692839384079,
-0.03677396476268768,
0.019993722438812256,
-0.004234663676470518,
0.0075641218572855,
0.007168094627559185,
0.010619189590215683,
-0.018941421061754227,
0.0052247317507863045,
0.015875037759542465,
0.0004108783323317766,
-0.009091655723750591,
0.0017198900459334254,
-0.006732464302331209,
0.0040621086955070496,
0.049786292016506195,
0.0191111471503973,
0.003459581406787038,
-0.02867237851023674,
-0.008667340502142906,
-0.011552682146430016,
-0.012887860648334026,
0.0218720231205225,
0.03844859451055527,
0.026137802749872208,
-0.019484544172883034,
-0.017436517402529716,
-0.0012637514155358076,
-0.027405090630054474,
-0.028785528615117073,
-0.001690187957137823,
0.0024355680216103792,
0.002551547484472394,
-0.05788787826895714,
-0.01754966750741005,
-0.006047903094440699,
0.0005137747502885759,
-0.002156934468075633,
0.022041749209165573,
-0.023286405950784683,
-0.01044380571693182,
-0.02324114553630352,
-0.015501640737056732,
0.005009745713323355,
0.0169499684125185,
0.0009957258589565754,
0.009204806759953499,
0.041729964315891266,
-0.014019367285072803,
0.060196153819561005,
0.044219277799129486,
-0.004625033121556044,
-0.015626106411218643,
-0.043178293853998184,
0.0011810100404545665,
-0.018749063834547997,
-0.008491957560181618,
-0.006240258924663067,
0.01241262722760439,
0.016010819002985954,
-0.011433874256908894,
0.05612272769212723,
-0.004514711443334818,
-0.009487682953476906,
-0.013679915107786655,
-0.019065886735916138,
0.00847498420625925,
-0.0021668351255357265,
0.01741388626396656,
0.005137039814144373,
0.0015869380440562963,
0.005207759328186512,
0.0012354637729004025,
-0.010562614537775517,
0.004361957777291536,
0.01846618764102459,
0.013872271403670311,
0.013091531582176685,
0.0068512726575136185,
-0.04209204763174057,
-0.07323110848665237,
0.01326125767081976,
0.011456504464149475,
-0.014426709152758121,
0.007863971404731274,
-0.015241393819451332,
0.03057330846786499,
0.02310536429286003,
-0.022664077579975128,
-0.009391505271196365,
0.03908224031329155,
0.03831281512975693,
-0.001070688129402697,
0.02776717208325863,
0.011643202975392342,
0.02514207735657692,
-0.01924692839384079,
0.01381569541990757,
-0.011937394738197327,
-0.008452353999018669,
0.01267287414520979,
-0.017244160175323486,
0.016078708693385124,
0.04394771531224251,
0.010466435924172401,
0.015388489700853825,
0.005883834324777126,
-0.016316326335072517,
0.03500881418585777,
0.0007552806637249887,
-0.0172102153301239,
-0.0026944000273942947,
-0.009136916138231754,
-0.02991703525185585,
-0.0037000265438109636,
0.012322107329964638,
-0.015422435477375984,
-0.004729697480797768,
0.022471722215414047,
0.031976375728845596,
-0.030098076909780502,
-0.000361021317075938,
0.0123673677444458,
0.021509941667318344,
-0.012831284664571285,
-0.011218887753784657,
-0.01231079176068306,
-0.025753090158104897,
0.003578389761969447,
0.009255724027752876,
-0.002486485755071044,
-0.020797092467546463,
0.027201419696211815,
0.00733216293156147,
-0.023127995431423187,
0.014166463166475296,
-0.02769928239285946,
0.004859820939600468,
0.011733723804354668,
-0.01831909269094467,
-0.015535585582256317,
-0.03279106318950653,
0.005946067161858082,
-0.002132890047505498,
-0.018692489713430405,
-0.0008663097396492958,
0.0035699033178389072,
-0.008989820256829262,
0.01267287414520979,
0.0066419439390301704,
0.011688463389873505,
0.017640188336372375,
-0.029373912140727043,
-0.0023676776327192783,
0.010992586612701416,
-0.03428465127944946,
-0.013487558811903,
-0.012231586501002312,
-0.02303747460246086,
-0.0037085129879415035,
-0.01034197025001049,
-0.011484792456030846,
0.00012976965808775276,
-0.06268546730279922,
-0.000859237858094275,
0.010409860871732235,
-0.01433618925511837,
0.028242405503988266,
0.01879432424902916,
-0.002080557867884636,
0.004944683983922005,
-0.015931613743305206,
0.029057089239358902,
0.012423942796885967,
0.04761379957199097,
-0.001147064846009016,
-0.02076314575970173,
0.027993474155664444,
0.024598954245448112,
-0.005086122080683708,
-0.008209080435335636,
-0.05648481100797653,
0.004673122428357601,
-0.01995977759361267,
0.012559723109006882,
-0.003057896625250578,
0.0057084509171545506,
0.003021122654899955,
0.017515722662210464,
-0.054764918982982635,
0.026567775756120682,
0.0006156103336252272,
-0.002152691362425685,
0.009861079975962639,
0.02971336431801319,
-0.004772129002958536,
0.01714232563972473,
0.005162498913705349,
0.03779232129454613,
-0.023535337299108505,
0.003151245880872011,
0.012288161553442478,
-0.019427968189120293,
-0.011597942560911179,
0.01397410687059164,
0.03378678858280182,
-0.02076314575970173,
0.0008677241276018322,
-0.02061605080962181,
-0.011586627922952175,
0.02264144830405712,
-0.04152629151940346,
-0.00038612663047388196,
0.04256727918982506,
0.023150624707341194,
0.0020381263457238674,
0.03403571993112564,
-0.05643954873085022,
-0.00952728558331728,
-0.030324377119541168,
-0.01689339429140091,
0.0038527799770236015,
-0.01984662562608719,
-0.009804504923522472,
0.03168218582868576,
0.0075641218572855,
0.006896532606333494,
0.05413127690553665,
0.02270933799445629,
-0.00884272437542677,
0.015863722190260887,
-0.006670231465250254,
-0.0016449277754873037,
0.020853666588664055,
-0.019292186945676804,
-0.009459394961595535,
0.0026944000273942947,
0.015592161566019058,
0.004616546910256147,
0.0235127080231905,
0.028310295194387436,
-0.0000681113961036317,
-0.004294067621231079,
-0.009419792331755161,
0.012876545079052448,
-0.04073423892259598,
0.005190786439925432,
0.10925827920436859,
-0.05304503068327904,
-0.02842344529926777,
-0.020785776898264885,
-0.0013846812071278691,
-0.011948710307478905,
0.02362585812807083,
-0.02468947507441044,
0.03412624076008797,
-0.0005265041836537421,
0.02677144668996334,
0.019620325416326523,
0.047885358333587646,
0.030618568882346153,
0.02541363798081875,
-0.005963040050119162,
0.02127232402563095,
0.03242897987365723,
0.0006905726040713489,
-0.03616295009851456,
-0.0028938280884176493,
0.0261151734739542,
0.012254216708242893,
0.0255946796387434,
-0.008056326769292355,
0.00930098444223404,
-0.01775333844125271,
-0.014370134100317955,
0.01489062700420618,
-0.007931861095130444,
0.015264024026691914,
-0.0006039416766725481,
0.02794821374118328,
-0.021623091772198677,
0.022301996126770973,
-0.028989199548959732,
-0.0067664096131920815,
-0.021905967965722084,
-0.005402944050729275,
-0.0026873282622545958,
0.003074869280681014,
0.008525902405381203,
-0.027088267728686333,
0.00466180732473731,
0.004429848399013281,
0.02520996704697609,
-0.02017476223409176,
0.009267039597034454,
-0.006924820598214865,
-0.014732216484844685,
-0.0014271127292886376,
0.005821601487696171,
0.01558084599673748,
-0.032972101122140884,
-0.042793579399585724,
-0.02455369383096695,
-0.004789101891219616,
-0.003926327917724848,
0.002554376143962145,
-0.011631888337433338,
0.009210463613271713,
0.019495859742164612,
0.007066258694976568,
-0.026137802749872208,
-0.004229005891829729
] | 2025-01-10 | 1 | 39792088 | [
"cancer immunotherapy",
"tumor heterogeneity",
"tumors",
"past failures",
"remarkable efficacy",
"recent breakthroughs",
"Adoptive T-cell therapy",
"hematological malignancies",
"issues",
"the cancer immunosurveillance concept",
"the cancer immunoediting concept",
"patients",
"approaches",
"reason",
"chimeric antigen-receptor T (CAR-T) cells",
"the immune system",
"the tumor microenvironment",
"first",
"the clinical success",
"an immune-checkpoint inhibitor",
"the scientific mechanism",
"the next step",
"the first approval",
"the therapies",
"these successes",
"this field",
"the population",
"the metabolism",
"that",
"we"
] | [
"CAR-T therapy",
"immune checkpoint inhibitor",
"tumor heterogeneity",
"tumor immunology"
] | 0 | 10.1093/intimm/dxaf002 | [
"Ikeda"
] | [
"Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4, Sakamoto, Nagasaki, 852-8523, Japan.\nLeading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4, Sakamoto, Nagasaki, 852-8523, Japan."
] | [
"39792088"
] | [] | 10.589274 | 4.138658 |
39791742 | 49 | CAR-T Therapy Beyond B-Cell Hematological Malignancies. | Despite the advances of CAR-T cells in certain hematological malignancies, mostly from B-cell derivations such as non-Hodgkin lymphomas, acute lymphoblastic leukemia and multiple myeloma, a significant portion of other hematological and non-hematological pathologies can benefit from this innovative treatment, as the results of clinical studies are demonstrating. The clinical application of CAR-T in the setting of acute T-lymphoid leukemia, acute myeloid leukemia, solid tumors, autoimmune diseases and infections has encountered limitations that are different from those of hematological B-cell diseases. To overcome these restrictions, strategies based on different molecular engineering platforms have been devised and will be illustrated below. The aim of this manuscript is to provide an overview of the CAR-T application in pathologies other than those currently treated, highlighting both the limits and results obtained with these settings. | [
0.009539337828755379,
0.007050318643450737,
0.0638011023402214,
0.03913925960659981,
-0.03009658306837082,
-0.023657100275158882,
-0.025438234210014343,
0.0064680250361561775,
-0.009756270796060562,
-0.0028415352571755648,
-0.026648491621017456,
-0.039458949118852615,
-0.04270152375102043,
0.023474421352148056,
0.013107312843203545,
-0.03459508344531059,
0.04735987260937691,
0.015858935192227364,
0.03142101317644119,
0.022549601271748543,
0.04080621525645256,
0.03329348936676979,
0.02961704693734646,
-0.004487085156142712,
-0.02564374916255474,
-0.05311430245637894,
-0.01770857349038124,
0.03913925960659981,
-0.03514312580227852,
-0.024364987388253212,
-0.0009105472126975656,
-0.01802826300263405,
-0.003790616523474455,
-0.03776915743947029,
0.010464156977832317,
0.05325131118297577,
0.03585101291537285,
0.02238975651562214,
-0.011149208061397076,
-0.016030197963118553,
0.041582606732845306,
0.01499120332300663,
0.0006607889663428068,
0.07741078734397888,
-0.09764263033866882,
-0.007706826087087393,
-0.014089219272136688,
-0.04959770664572716,
-0.0022792224772274494,
-0.009242482483386993,
0.004238754045218229,
0.005588876083493233,
-0.009002714417874813,
0.0014928407035768032,
-0.020985402166843414,
0.032631270587444305,
-0.018256613984704018,
0.007912341505289078,
0.002359145088121295,
-0.01644122786819935,
-0.019820814952254295,
-0.010458447970449924,
0.0019224248826503754,
-0.016669578850269318,
-0.052611932158470154,
0.029776891693472862,
-0.06782006472349167,
-0.05293162167072296,
-0.015995945781469345,
0.015390817075967789,
0.008037934079766273,
-0.01703494042158127,
-0.012616359628736973,
0.004586988594383001,
0.011388976126909256,
-0.004512774758040905,
-0.01885032467544079,
0.04493935778737068,
0.0008448964799754322,
0.00788950640708208,
0.03760930895805359,
-0.002496155211701989,
0.010292894206941128,
-0.04628662392497063,
-0.0276303980499506,
0.015322311781346798,
0.00799226388335228,
-0.01405496709048748,
-0.015527826733887196,
-0.022618107497692108,
-0.04375193640589714,
0.012319504283368587,
-0.02564374916255474,
0.03482343629002571,
-0.008380459621548653,
0.02527838945388794,
-0.004150268621742725,
-0.03324781730771065,
0.031009983271360397,
0.056950587779283524,
0.03384152799844742,
0.010275768116116524,
-0.029365861788392067,
-0.0324714258313179,
0.05772697925567627,
0.013529760763049126,
-0.03384152799844742,
-0.024661842733621597,
0.01694360002875328,
0.008608809672296047,
0.035348642617464066,
-0.04395745322108269,
0.005409050267189741,
0.05407337471842766,
-0.03802034258842468,
-0.0638011023402214,
-0.045236214995384216,
-0.011240548454225063,
0.002714515430852771,
0.016429811716079712,
-0.02858947031199932,
0.051104817539453506,
-0.0024404949508607388,
-0.02349725551903248,
-0.001829657587222755,
0.000013781303096038755,
0.0962725281715393,
0.0009576444863341749,
-0.02422797679901123,
-0.03834003210067749,
0.02963988110423088,
0.022606689482927322,
0.011349014937877655,
-0.02321181818842888,
-0.07421387732028961,
0.00500943697988987,
-0.022595271468162537,
-0.004458541516214609,
-0.012764787301421165,
-0.031124159693717957,
0.023588595911860466,
-0.018998753279447556,
-0.004432851914316416,
-0.0036250625271350145,
-0.047222863882780075,
-0.022743700072169304,
0.016509734094142914,
0.012045483104884624,
0.0009612124413251877,
0.05763563886284828,
-0.021213751286268234,
0.052977293729782104,
0.017719991505146027,
0.02065429277718067,
-0.00034609358408488333,
-0.053433991968631744,
0.003599373158067465,
0.05311430245637894,
-0.029708387330174446,
-0.028886325657367706,
-0.003904791781678796,
-0.019969241693615913,
-0.03153518959879875,
-0.001091086771339178,
0.0010575477499514818,
-0.04265585541725159,
0.009967494755983353,
0.0215676948428154,
-0.029206015169620514,
-0.00017625796317588538,
-0.03116982989013195,
-0.04060070216655731,
-0.0623396597802639,
-0.02751622349023819,
-0.02715086191892624,
0.021385014057159424,
0.03395570442080498,
-0.004795358516275883,
-0.01606445014476776,
-0.034640755504369736,
0.012696282006800175,
0.032973796129226685,
0.009710600599646568,
-0.019912155345082283,
-0.023451585322618484,
0.020391689613461494,
-0.035234466195106506,
0.012799039483070374,
-0.031329672783613205,
-0.017206203192472458,
0.012844709679484367,
0.0005687351804226637,
0.042404670268297195,
0.02610045112669468,
0.01805109903216362,
0.018633391708135605,
0.01906725764274597,
-0.0031911968253552914,
-0.02610045112669468,
-0.05832068994641304,
0.05430172383785248,
-0.020894061774015427,
-0.024890193715691566,
-0.007900923490524292,
-0.042267657816410065,
0.0170920267701149,
-0.005925692617893219,
0.030507612973451614,
-0.0090940548107028,
-0.009916115552186966,
0.01275336928665638,
0.0023463002871721983,
-0.02386261709034443,
0.03514312580227852,
-0.027927253395318985,
-0.01626996509730816,
0.0008420420926995575,
0.03895657882094383,
0.0015642002690583467,
0.03900224715471268,
-0.01305022556334734,
-0.03411554917693138,
-0.01626996509730816,
0.043797604739665985,
-0.04959770664572716,
0.007752495817840099,
-0.01736604794859886,
-0.04340941086411476,
0.010355690494179726,
-0.01042990479618311,
0.019432619214057922,
-0.015322311781346798,
0.022663777694106102,
-0.048638634383678436,
-0.012068318203091621,
-0.01793692447245121,
-0.013666771352291107,
-0.003873393638059497,
0.03831719607114792,
-0.024410657584667206,
0.008306245319545269,
0.024068132042884827,
0.004435706418007612,
0.0039304811507463455,
-0.0021336490754038095,
-0.030439108610153198,
-0.010338564403355122,
-0.05964512377977371,
0.03082730434834957,
-0.010898022912442684,
0.00864306278526783,
0.011565947905182838,
-0.014523085206747055,
-0.002637447090819478,
0.040029823780059814,
0.004258735105395317,
0.017662903293967247,
-0.02765323407948017,
0.0109265660867095,
-0.030530449002981186,
-0.015767594799399376,
0.0023391644936054945,
-0.026968181133270264,
-0.03774632140994072,
-0.03820302337408066,
0.008380459621548653,
-0.010110213421285152,
0.03918492794036865,
0.06517120450735092,
-0.042518842965364456,
0.05270327255129814,
0.046743325889110565,
0.002234979532659054,
-0.03587384894490242,
-0.029913902282714844,
-0.0008370469440706074,
-0.002793010789901018,
0.01714911498129368,
-0.0036564606707543135,
0.01640697568655014,
0.007204454857856035,
0.01229666918516159,
0.008568848483264446,
-0.036490391939878464,
-0.0032454300671815872,
-0.026077615097165108,
0.0045470274053514,
0.019683804363012314,
0.02252676710486412,
-0.02332599274814129,
0.01714911498129368,
0.006017033010721207,
-0.0021350763272494078,
-0.04676616191864014,
0.028429623693227768,
0.006308179814368486,
0.018245195969939232,
0.013849451206624508,
-0.018462128937244415,
0.006388102192431688,
-0.008357624523341656,
-0.006159752141684294,
-0.019055841490626335,
-0.03295096382498741,
0.01626996509730816,
0.0324714258313179,
-0.012308086268603802,
-0.007370009087026119,
0.04612677916884422,
0.008146400563418865,
0.01027005910873413,
-0.014854193665087223,
0.026283130049705505,
0.012844709679484367,
-0.022572437301278114,
-0.008797199465334415,
0.014077802188694477,
-0.07261542975902557,
0.03587384894490242,
-0.06160893663764,
-0.03543998301029205,
-0.011685831472277641,
-0.02034602127969265,
0.03676441311836243,
0.0038762479089200497,
-0.019797978922724724,
0.028886325657367706,
-0.0107838474214077,
0.02564374916255474,
-0.04411729797720909,
-0.004050365183502436,
-0.027013851329684258,
0.036992765963077545,
-0.0016526860417798162,
0.0043586380779743195,
0.016338471323251724,
0.004886698443442583,
-0.015379399061203003,
0.015242389403283596,
0.01870189793407917,
-0.007592650596052408,
0.037106938660144806,
-0.029228851199150085,
0.0690988302230835,
0.01697785221040249,
-0.004752542823553085,
0.006747754290699959,
0.010869478806853294,
-0.023816946893930435,
0.030850138515233994,
-0.026168955489993095,
-0.02717369794845581,
0.027493387460708618,
0.026031944900751114,
0.003179779276251793,
0.05137883871793747,
-0.05124182999134064,
-0.023337410762906075,
0.01564200222492218,
-0.008831451646983624,
-0.00039675881271250546,
-0.018964501097798347,
-0.05946244299411774,
0.04448265582323074,
0.0727524384856224,
0.05822934955358505,
-0.03126116842031479,
-0.007113114930689335,
-0.03948178514838219,
-0.031124159693717957,
-0.007073153741657734,
0.01174862775951624,
0.011531694792211056,
-0.007250125054270029,
-0.006370976101607084,
0.049460697919130325,
0.012433678843080997,
0.014431744813919067,
0.006947560701519251,
0.03253993019461632,
0.034640755504369736,
-0.004586988594383001,
-0.016498316079378128,
-0.04041802138090134,
-0.027676068246364594,
0.03164936602115631,
-0.02191022038459778,
-0.0007821001345291734,
-0.06279636174440384,
0.052977293729782104,
-0.003813451621681452,
-0.003987568896263838,
0.017240455374121666,
-0.00999032985419035,
-0.019763726741075516,
0.09284727275371552,
-0.040144000202417374,
0.08330222219228745,
0.032380085438489914,
-0.03080446831882,
-0.0007742505404166877,
-0.02539256401360035,
-0.017411718145012856,
-0.04105740040540695,
0.03573683649301529,
-0.02904617041349411,
0.015219554305076599,
0.03505178540945053,
0.03139818087220192,
-0.046172451227903366,
-0.000004454393547348445,
0.016897929832339287,
0.039093587547540665,
0.023109059780836105,
0.017982594668865204,
-0.023702770471572876,
-0.02998240664601326,
0.026876842603087425,
-0.04153693839907646,
0.040623534470796585,
0.041468434035778046,
-0.044642504304647446,
0.010726760141551495,
-0.013210070319473743,
0.007210163865238428,
-0.02032318525016308,
0.048638634383678436,
0.03537147492170334,
-0.008791490457952023,
-0.020620040595531464,
-0.03715261071920395,
0.03269977867603302,
0.0006283203838393092,
-0.006662122905254364,
-0.042381834238767624,
0.042747195810079575,
-0.0058800228871405125,
0.03927626833319664,
-0.01001887395977974,
0.03388720005750656,
-0.030028076842427254,
0.020791303366422653,
0.013118729926645756,
-0.00843183882534504,
0.03703843429684639,
0.018176691606640816,
-0.01835937239229679,
0.03176353871822357,
-0.046720489859580994,
-0.016247130930423737,
-0.008911374025046825,
-0.029343025758862495,
-0.019900737330317497,
0.006085538305342197,
-0.032859623432159424,
-0.014020713977515697,
0.0244563277810812,
-0.07558397948741913,
0.024182306602597237,
0.03843137249350548,
0.0012266697594895959,
-0.009921824559569359,
0.006359558552503586,
-0.0349147766828537,
0.010835226625204086,
0.04420863837003708,
0.04217631742358208,
-0.024022461846470833,
0.0015113941626623273,
-0.04644647240638733,
0.061106566339731216,
0.004161686170846224,
-0.0006854080129414797,
-0.012730535119771957,
-0.02941153198480606,
0.059325434267520905,
0.03153518959879875,
-0.0019852211698889732,
0.031238334253430367,
0.011874220333993435,
-0.013780946843326092,
-0.024250812828540802,
-0.01759439893066883,
-0.03235725313425064,
0.02927452139556408,
0.022823622450232506,
-0.011725792661309242,
0.02409096620976925,
-0.03388720005750656,
0.03726678341627121,
-0.012330921366810799,
-0.006462316028773785,
0.01458017248660326,
-0.009613552130758762,
-0.01258210651576519,
-0.0170920267701149,
-0.018656227737665176,
-0.027082357555627823,
-0.03210606426000595,
-0.0031312548089772463,
0.01188563834875822,
0.018096769228577614,
-0.021944472566246986,
0.04681183025240898,
0.05841203033924103,
0.021133828908205032,
0.0023163293953984976,
0.02246967889368534,
0.01054407935589552,
-0.003822014667093754,
-0.03763214498758316,
-0.01634988933801651,
0.06311605125665665,
-0.000043462394387461245,
-0.030713127925992012,
-0.025118542835116386,
-0.08923933655023575,
-0.009801940992474556,
-0.005377651657909155,
-0.00661645270884037,
-0.012536437250673771,
0.0048981159925460815,
-0.033453334122896194,
-0.011588783003389835,
0.031329672783613205,
-0.017582980915904045,
-0.01692076399922371,
0.0019424055935814977,
-0.002550388453528285,
-0.011897055432200432,
0.02918318100273609,
-0.01229666918516159,
-0.025689419358968735,
0.015995945781469345,
-0.005554623436182737,
-0.03329348936676979,
-0.05092214047908783,
0.032174572348594666,
-0.027128027752041817,
-0.03343049809336662,
0.01340416818857193,
-0.006553656421601772,
0.03916209191083908,
-0.013906539417803288,
-0.006627870257943869,
0.011172043159604073,
0.011771462857723236,
-0.024273646995425224,
0.01188563834875822,
-0.005623128730803728,
0.01912434585392475,
-0.013438421301543713,
0.037198279052972794,
-0.003699276363477111,
0.03660456836223602,
-0.010726760141551495,
-0.025917770341038704,
-0.03820302337408066,
-0.006439481396228075,
-0.01759439893066883,
-0.007364300545305014,
-0.0021065324544906616,
0.008637353777885437,
0.010224388912320137,
-0.018998753279447556,
0.05325131118297577,
0.000627606816124171,
-0.01765148527920246,
-0.05352533236145973,
0.0045270468108356,
-0.009111180901527405,
0.008329080417752266,
0.026283130049705505,
0.0013472673017531633,
0.03770064935088158,
0.008334789425134659,
0.004544172901660204,
0.01768573746085167,
-0.022012978792190552,
0.005885731428861618,
-0.004281569737941027,
-0.017662903293967247,
-0.0181881096214056,
0.047085851430892944,
-0.01282187458127737,
0.023200400173664093,
-0.02655715122818947,
0.01163445319980383,
-0.023360244929790497,
0.00885428674519062,
0.04425430670380592,
0.013529760763049126,
0.005919984076172113,
0.028749315068125725,
-0.05457574501633644,
0.026991017162799835,
0.023839781060814857,
0.012570689432322979,
-0.004181666765362024,
-0.010903731919825077,
-0.01830228418111801,
-0.019192850217223167,
0.00021247290715109557,
-0.028498129919171333,
-0.024981534108519554,
0.017206203192472458,
-0.002451912499964237,
-0.012662029825150967,
0.01748022250831127,
0.0030770215671509504,
0.048044923692941666,
0.04087471961975098,
-0.0323115810751915,
-0.018268031999468803,
0.03868255764245987,
0.026077615097165108,
-0.02493586391210556,
-0.018998753279447556,
0.024136636406183243,
-0.01770857349038124,
0.0011010770685970783,
0.0036107907071709633,
-0.006947560701519251,
-0.023588595911860466,
0.027676068246364594,
-0.04044085368514061,
-0.02470751293003559,
0.0025760778225958347,
0.015002621337771416,
-0.0034281103871762753,
0.005971362814307213,
-0.035462815314531326,
-0.0003746373695321381,
0.00943658035248518,
-0.003088439116254449,
-0.021430684253573418,
0.011269092559814453,
-0.02397679165005684,
0.005999906919896603,
0.0011339024640619755,
-0.023223236203193665,
-0.0037135484162718058,
-0.01041277777403593,
-0.040395185351371765,
0.013701023533940315,
-0.023246070370078087,
-0.02091689594089985,
-0.002203581389039755,
0.010526953265070915,
-0.012102571316063404,
-0.002656000666320324,
-0.01470576599240303,
0.0395502895116806,
-0.03281395137310028,
0.012182493694126606,
-0.00719874631613493,
-0.011594491079449654,
-0.019227104261517525,
0.07161068171262741,
0.0738941878080368,
-0.037449464201927185,
0.017411718145012856,
0.009527920745313168,
0.009904698468744755,
-0.00964780431240797,
0.002386261709034443,
0.02986823208630085,
-0.007404261734336615,
0.007398552726954222,
0.01470576599240303,
0.06896182149648666,
0.041925132274627686,
-0.002340591512620449,
-0.010447030887007713,
0.0027530493680387735,
0.012970302253961563,
0.013449838384985924,
-0.014169142581522465,
-0.036878589540719986,
0.0289319958537817,
-0.017834166064858437,
-0.0007585514686070383,
-0.03139818087220192,
-0.03706127032637596,
-0.020083418115973473,
0.00943658035248518,
0.03977863863110542,
0.021841716021299362,
0.017308959737420082,
0.000007615396498295013,
0.013152983039617538,
-0.002700243378058076,
-0.010361399501562119,
-0.007238707505166531,
0.037221115082502365,
0.027447717264294624,
-0.0029913901817053556,
-0.017080610617995262,
-0.021716123446822166,
-0.016190042719244957,
0.023816946893930435,
0.01893024705350399,
0.04060070216655731,
-0.05594584718346596,
0.02598627470433712,
0.003308226354420185,
0.0197751447558403,
-0.029206015169620514,
0.0184735469520092,
0.039824310690164566,
0.0032511388417333364,
0.004995164927095175,
-0.01581326499581337,
-0.021270839497447014,
-0.007752495817840099,
-0.011172043159604073,
0.0004228050238452852,
0.024479161947965622,
0.011628744192421436,
0.032859623432159424,
0.009613552130758762,
0.0360565260052681,
-0.008095021359622478,
-0.007775330916047096,
0.013084477744996548,
0.04201647266745567,
-0.0212822575122118,
0.06631295382976532,
0.003097002161666751,
-0.024730348959565163,
0.007370009087026119,
-0.023953957483172417,
-0.027493387460708618,
-0.012342339381575584,
0.0025803595781326294,
0.0035594117362052202,
-0.038157351315021515,
-0.014020713977515697,
-0.009716309607028961,
-0.020357437431812286,
0.03596518933773041,
-0.03585101291537285,
-0.039915651082992554,
0.036787249147892,
0.0012816166272386909,
0.0006072693504393101,
0.041925132274627686,
-0.008174944669008255,
-0.0054832641035318375,
-0.026260295882821083,
0.0024790288880467415,
0.006998939905315638,
0.016760919243097305,
-0.009893281385302544,
0.010486992076039314,
-0.023908287286758423,
-0.009459415450692177,
0.009036966599524021,
-0.03667307272553444,
-0.02409096620976925,
-0.015151049010455608,
0.021784627810120583,
-0.0074841841123998165,
-0.010749595239758492,
-0.02076846919953823,
-0.012799039483070374,
0.014523085206747055,
0.02267519384622574,
0.00013406666403170675,
0.012091153301298618,
-0.026648491621017456,
-0.018770402297377586,
0.0181881096214056,
-0.030393438413739204,
-0.005026563070714474,
0.03964162990450859,
-0.005212097894400358,
-0.001255213632248342,
0.0064680250361561775,
0.006582200061529875,
0.002147920895367861,
-0.007958011701703072,
-0.009008423425257206,
-0.004521337803453207,
0.0008413285249844193,
-0.01027005910873413,
0.0018967355135828257,
0.0021679014898836613,
-0.030393438413739204,
0.006644996348768473,
-0.012913214974105358,
0.034275393933057785,
-0.025483904406428337,
0.021601947024464607,
-0.009493667632341385,
0.027927253395318985,
0.03877389803528786,
-0.08859995752573013,
-0.016372723504900932,
-0.0066906665451824665,
-0.03669590875506401,
0.009716309607028961,
0.006011324003338814,
-0.03080446831882,
0.006142625585198402,
0.017834166064858437,
0.0024333589244633913,
0.018039681017398834,
-0.035576991736888885,
0.019512541592121124,
0.018256613984704018,
-0.007786748465150595,
-0.016190042719244957,
0.02105390653014183,
-0.06092388555407524,
-0.01774282567203045,
0.02550673857331276,
0.0052777486853301525,
0.002396252006292343,
-0.014009296894073486,
0.05758997052907944,
-0.029571376740932465,
-0.007878088392317295,
-0.0021921638399362564,
-0.02374844066798687,
-0.03879673406481743,
0.0029086132999509573,
0.0032140319235622883,
0.015265224501490593,
-0.050511106848716736,
0.02250393107533455,
0.01439749263226986,
-0.024045296013355255,
0.03813451528549194,
-0.008597392588853836,
-0.00857455749064684,
0.0001522633247077465,
-0.013369916006922722,
0.02468467876315117,
0.030621787533164024,
0.010686798952519894,
-0.018975917249917984,
0.00899700541049242,
-0.03128400444984436,
-0.007227289956063032,
0.02717369794845581,
-0.021499190479516983,
0.0017054920317605138,
-0.02326890639960766,
-0.03142101317644119,
0.002280649496242404,
-0.005999906919896603,
-0.036262042820453644,
-0.033110808581113815,
0.05288595333695412,
0.0018824635772034526,
0.00014164860476739705,
-0.006205421872437,
0.047314200550317764,
0.04292987659573555,
-0.01306164264678955,
0.0006097669247537851,
-0.002002347493544221,
-0.05064811930060387,
0.04222198948264122,
-0.0634814128279686,
0.022937797009944916,
-0.01174862775951624,
0.018770402297377586,
-0.010898022912442684,
0.03518879786133766,
-0.00729008624330163,
0.0066507053561508656,
0.0036564606707543135,
0.00128233025316149,
-0.009419454261660576,
-0.013152983039617538,
-0.02057437039911747,
-0.030073747038841248,
-0.039207763969898224,
0.0036564606707543135,
-0.03185487911105156,
0.007535563316196203,
-0.011651579290628433,
0.020791303366422653,
0.008129274472594261,
-0.027105191722512245,
-0.009345239959657192,
-0.002517563058063388,
-0.0004567007999867201,
-0.002020901069045067,
-0.036855753511190414,
-0.012662029825150967,
-0.013838034123182297,
-0.0036164994817227125,
0.011805715970695019,
-0.024958698078989983,
0.0354856513440609,
-0.04400312155485153,
0.0026802627835422754,
0.006530821323394775,
-0.02822410874068737,
-0.01239942666143179,
0.01728612557053566,
-0.023611431941390038,
-0.0008841442177072167,
-0.021522024646401405,
0.04496219381690025,
-0.02074563317000866,
0.00830053724348545,
-0.021487772464752197,
-0.011006489396095276,
-0.0032311580143868923,
0.024045296013355255,
-0.016532568261027336,
0.017834166064858437,
-0.00032290173112414777,
0.06763739138841629,
0.03948178514838219,
-0.026602821424603462,
-0.005055106710642576,
0.0020737070590257645,
-0.014112054370343685,
0.010840934701263905,
0.014363240450620651,
0.00339385773986578,
0.0122281638905406,
0.036033693701028824,
0.0016141518717631698,
-0.0062853447161614895,
-0.0002502934366930276,
0.0023505818098783493,
0.017377465963363647,
0.025461070239543915,
0.02216140553355217,
0.03185487911105156,
0.0138151990249753,
0.000033360567613271996,
0.005329127423465252,
0.019569629803299904,
0.006582200061529875,
0.05434739589691162,
-0.033910032361745834,
-0.027790242806077003,
0.026762666180729866,
-0.0072615426033735275,
-0.0028001468162983656,
-0.04311255365610123,
0.04477951303124428,
0.02541540004312992,
0.06297904253005981,
-0.009042675606906414,
-0.001487131929025054,
-0.004692600574344397,
-0.015767594799399376,
-0.009430871345102787,
0.03260843828320503,
-0.02906900644302368,
0.0328824557363987,
-0.05124182999134064,
-0.01833653636276722,
0.02411380223929882,
-0.014956951141357422,
-0.016646744683384895,
0.017662903293967247,
0.02868081070482731,
0.017206203192472458,
-0.0051435925997793674,
-0.03770064935088158,
0.023143311962485313,
-0.014443162828683853,
-0.002874360652640462,
0.019855067133903503,
0.021830298006534576,
-0.0041045984253287315,
0.013655353337526321,
0.023588595911860466,
-0.0024419219698756933,
0.014386074617505074,
0.006821968127042055,
0.03724395111203194,
0.008391876704990864,
-0.01862197555601597,
-0.011074994690716267,
-0.005037980619817972,
0.0044842311181128025,
-0.002942865714430809,
-0.01850779913365841,
-0.034252557903528214,
0.02212715335190296,
0.0386597216129303,
0.0323115810751915,
-0.041673947125673294,
-0.02153344266116619,
0.010007455945014954,
-0.0432952344417572,
-0.019204268231987953,
-0.06905315816402435,
0.03069029375910759,
0.04324956610798836,
-0.01918143406510353,
-0.028886325657367706,
0.04130858555436134,
-0.0004156690847594291,
-0.02275511622428894,
0.0072843777015805244,
0.037791989743709564,
-0.010555497370660305,
0.056402549147605896,
-0.024616172537207603,
0.053799353539943695,
-0.0019409783417358994,
0.0034052752889692783,
0.023131895810365677,
-0.0021464936435222626,
-0.016897929832339287,
-0.012273834086954594,
-0.028657974675297737,
-0.037335291504859924,
0.01137755811214447,
-0.018667645752429962,
0.009898989461362362,
0.01805109903216362,
0.055078115314245224,
0.01791408844292164,
0.006844803225249052,
0.00947654154151678,
-0.04292987659573555,
0.01070963405072689,
0.04525904729962349,
0.018804654479026794,
-0.01323290541768074,
0.0005719463806599379,
-0.011212004348635674,
-0.02334882877767086,
-0.0037478008307516575,
-0.023143311962485313,
0.05279461294412613,
0.04160544276237488,
-0.011400393210351467,
-0.03541714698076248,
-0.010601167567074299,
0.005249204579740763,
0.046743325889110565,
-0.03164936602115631,
0.010041709057986736,
-0.00843183882534504,
-0.01728612557053566,
0.012490767054259777,
0.029457202181220055,
0.045464564114809036,
0.04153693839907646,
0.0028543800581246614,
0.004107452929019928,
0.0037677816580981016,
0.02071138098835945,
0.014214811846613884,
-0.004070345778018236,
0.003813451621681452,
0.005577458534389734,
-0.007392844185233116,
0.009019840508699417,
0.02409096620976925,
0.006559364963322878,
-0.030507612973451614,
0.03116982989013195,
0.029206015169620514,
0.012136823497712612,
0.00726725161075592,
-0.009784814901649952,
0.004444269463419914,
-0.00996178574860096,
-0.019375531002879143,
0.019204268231987953,
-0.019992077723145485,
-0.003764927154406905,
0.008888538926839828,
0.0037249659653753042,
-0.002874360652640462,
-0.030895808711647987,
-0.006565073970705271,
0.026374470442533493,
0.0038448497653007507,
-0.014431744813919067,
-0.029480036348104477,
-0.003085584845393896,
-0.030028076842427254,
-0.029548540711402893,
0.014020713977515697,
-0.02587210014462471,
-0.018210943788290024,
-0.025552408769726753,
-0.024364987388253212,
-0.005471846554428339,
-0.008055060170590878,
-0.015425069257616997,
-0.008660188876092434,
0.002363426610827446,
0.03843137249350548,
-0.005174990743398666,
-0.008283410221338272,
-0.0007153789629228413,
-0.006884764414280653,
-0.04571574926376343,
-0.03406988084316254,
0.034617919474840164,
0.0024990097153931856,
-0.038180187344551086,
0.025438234210014343,
0.000024931225198088214,
-0.02124800533056259,
-0.0002827620191965252,
0.01740030013024807,
-0.01475143525749445,
0.01915859803557396,
0.025324059650301933,
0.02116808108985424,
-0.0005544633022509515,
-0.005212097894400358,
0.0054518659599125385,
-0.019683804363012314,
-0.035097457468509674,
-0.0012252426240593195,
0.03916209191083908,
0.011565947905182838,
-0.025209883227944374,
-0.03856838122010231,
0.016543986275792122,
-0.018484964966773987,
0.02635163627564907,
-0.024136636406183243,
0.0008049351745285094,
-0.006879055872559547,
0.004883843939751387,
-0.01095511019229889,
-0.01008737925440073,
-0.016738085076212883,
0.010829517617821693,
0.003508032998070121,
0.007866671308875084,
0.020380273461341858,
0.02111099474132061,
0.007912341505289078,
-0.02491302788257599,
-0.02621462568640709,
-0.029023336246609688,
-0.017845584079623222,
0.05457574501633644,
-0.017582980915904045,
-0.044756677001714706,
0.044848017394542694,
0.022252745926380157,
-0.014340405352413654,
0.0040960353799164295,
-0.02256101928651333,
0.010806682519614697,
0.01470576599240303,
0.002902904525399208,
0.04267868772149086,
0.042861368507146835,
-0.006833385676145554,
0.007564106956124306,
0.020106252282857895,
-0.02564374916255474,
-0.01429473515599966,
-0.010304311290383339,
0.011862803250551224,
0.010749595239758492,
0.02998240664601326,
-0.027310706675052643,
-0.0032911000307649374,
0.0012830437626689672,
0.004735416267067194,
0.04608111083507538,
0.03790616616606712,
0.004655493889003992,
0.012376591563224792,
-0.004341511987149715,
-0.001505685388110578,
-0.001141038374044001,
-0.007626903243362904,
0.001995211699977517,
0.007781039923429489,
-0.01751447468996048,
-0.03916209191083908,
0.004201647359877825,
0.014112054370343685,
0.005954236723482609,
-0.026488646864891052,
0.0036107907071709633,
-0.02340591512620449,
-0.03176353871822357,
0.010212971828877926,
0.0013729567872360349,
0.007604068145155907,
-0.012171076610684395,
0.009482250548899174,
-0.04149126634001732,
-0.006348141003400087,
0.002267804928123951,
0.006422354839742184,
0.004418580327183008,
0.02363426610827446,
0.013666771352291107,
0.019592463970184326,
0.027904419228434563,
0.01669241487979889,
-0.02133934386074543,
0.00370498513802886,
-0.05370801314711571,
0.01606445014476776,
-0.02470751293003559,
-0.000926246284507215,
0.007124532479792833,
-0.02539256401360035,
-0.026534317061305046,
0.0014771416317671537,
0.008962753228843212,
-0.0024105238262563944,
-0.020620040595531464,
0.021556276828050613,
0.016760919243097305,
0.00038676848635077477,
0.01470576599240303,
-0.000345558364642784,
-0.025255553424358368,
0.0032511388417333364,
-0.0036707327235490084,
0.020779885351657867,
0.019718056544661522,
-0.0006946847424842417,
-0.02059720642864704,
0.009362366050481796,
-0.01470576599240303,
-0.009179686196148396,
-0.001168154994957149,
0.006696375552564859,
0.009470832534134388,
-0.0024148053489625454,
0.061563268303871155,
0.005620274227112532,
0.013917956501245499,
-0.014694347977638245,
-0.03306513652205467,
-0.016532568261027336,
0.004084617830812931,
0.0090540936216712,
0.026168955489993095,
0.01887316070497036,
-0.03667307272553444,
-0.01904442347586155,
-0.02411380223929882,
-0.022229911759495735,
-0.0380888469517231,
-0.01858772151172161,
0.008534596301615238,
0.02635163627564907,
-0.02224132791161537,
-0.006776297930628061,
-0.0015413651708513498,
0.0170920267701149,
0.01768573746085167,
-0.0017240454908460379,
-0.037791989743709564,
-0.020734217017889023,
0.006370976101607084,
0.008734402246773243,
0.017582980915904045,
0.035919517278671265,
0.045236214995384216,
0.02091689594089985,
0.01487702876329422,
-0.03199189156293869,
0.036284878849983215,
0.005902857985347509,
0.019649552181363106,
-0.030416272580623627,
-0.02374844066798687,
0.004061782732605934,
0.008369042538106441,
-0.006273927167057991,
0.020677128806710243,
0.02252676710486412,
-0.01986648514866829,
-0.036969929933547974,
0.021145246922969818,
-0.02071138098835945,
0.0052691856399178505,
-0.007592650596052408,
0.0004556303902063519,
0.0018739004153758287,
-0.015379399061203003,
-0.003873393638059497,
-0.0003910500672645867,
-0.03610219806432724,
-0.008095021359622478,
0.0032511388417333364,
-0.029913902282714844,
0.03884240239858627,
0.0005145019968040287,
-0.01540223415941,
0.007758204825222492,
0.012342339381575584,
-0.051561519503593445,
-0.07334614545106888,
0.00560314767062664,
0.003385294694453478,
-0.01606445014476776,
0.00527203967794776,
-0.006188295781612396,
0.01025864202529192,
0.02667132578790188,
-0.04302121326327324,
0.009071219712495804,
0.04404878988862038,
0.034526579082012177,
-0.007672573439776897,
-0.0001652864448260516,
0.00006110157119110227,
0.01952395960688591,
-0.002760185394436121,
-0.016555404290556908,
-0.026168955489993095,
0.015790430828928947,
0.03703843429684639,
-0.008220613934099674,
0.011999813839793205,
0.025963440537452698,
0.008568848483264446,
0.011451772414147854,
-0.002544679678976536,
-0.021156664937734604,
0.0328824557363987,
-0.0107838474214077,
-0.02202439494431019,
-0.00582293514162302,
-0.006365267559885979,
-0.03185487911105156,
0.025689419358968735,
0.005443302448838949,
-0.01816527359187603,
0.01205690111964941,
0.0035251593217253685,
0.042267657816410065,
0.0007064590463414788,
-0.020665710791945457,
-0.011874220333993435,
0.05147017911076546,
-0.002778738969936967,
0.002240688307210803,
-0.014740018174052238,
-0.02159053087234497,
-0.01464867778122425,
-0.008620227687060833,
-0.006416646298021078,
-0.02122516930103302,
0.029023336246609688,
-0.013255740515887737,
-0.002303484594449401,
0.011651579290628433,
-0.006034159101545811,
0.013084477744996548,
-0.01481994055211544,
-0.028155604377388954,
-0.009522211737930775,
-0.034869104623794556,
-0.01632705330848694,
-0.008859995752573013,
0.003276828210800886,
-0.023451585322618484,
0.003947607707232237,
-0.017719991505146027,
0.02541540004312992,
-0.004684037528932095,
0.027950089424848557,
-0.002979972632601857,
-0.026146121323108673,
-0.03279111534357071,
0.008648770861327648,
-0.018542053177952766,
0.03388720005750656,
-0.014009296894073486,
0.0008884257404133677,
-0.034412406384944916,
-0.007518436759710312,
0.002332028467208147,
0.011035032570362091,
-0.02667132578790188,
0.02655715122818947,
0.0012980293249711394,
-0.01901017129421234,
0.024616172537207603,
0.01833653636276722,
-0.00895704422146082,
0.0013294274685904384,
-0.017548728734254837,
-0.005800100043416023,
-0.014363240450620651,
0.04000699147582054,
-0.006924725603312254,
-0.0341840535402298,
-0.004958057776093483,
-0.013210070319473743,
-0.02785874903202057,
-0.022846456617116928,
-0.046720489859580994,
-0.017777077853679657,
0.015390817075967789,
0.02552957460284233,
-0.0011738637695088983,
-0.002550388453528285,
-0.012113988399505615,
0.03178637474775314,
-0.04539605975151062,
0.0037392377853393555,
-0.006696375552564859,
0.010367108508944511,
0.0232346523553133,
0.04868430644273758,
-0.0011767181567847729,
0.0026203207671642303,
-0.004535609856247902,
0.011240548454225063,
-0.020414525642991066,
-0.012022648006677628,
-0.0012066891649737954,
-0.0034652173053473234,
-0.03295096382498741,
0.030964313074946404,
0.034983281046152115,
-0.02916034497320652,
-0.0062453835271298885,
-0.03754080459475517,
-0.021442102268338203,
0.024387821555137634,
-0.019364112988114357,
0.012616359628736973,
-0.0024447764735668898,
0.015516409650444984,
0.012867544777691364,
0.029091840609908104,
-0.032631270587444305,
0.01940978318452835,
-0.01734321191906929,
-0.013027390465140343,
0.002723078476265073,
0.00101687281858176,
-0.013849451206624508,
0.01895308308303356,
0.012125406414270401,
0.014557337388396263,
0.029206015169620514,
0.009282443672418594,
0.01316440012305975,
0.01623571291565895,
-0.01703494042158127,
-0.0023463002871721983,
0.014477415010333061,
0.00823203194886446,
-0.021042488515377045,
0.04041802138090134,
0.012330921366810799,
0.020894061774015427,
0.04493935778737068,
0.002851525554433465,
-0.021019654348492622,
0.008939918130636215,
-0.009362366050481796,
-0.011360432021319866,
-0.026283130049705505,
0.0014328986871987581,
0.13189518451690674,
-0.004626949783414602,
-0.02363426610827446,
0.00560314767062664,
-0.008329080417752266,
-0.00847180001437664,
0.024501997977495193,
0.015516409650444984,
0.02388545125722885,
-0.015447904355823994,
0.01357543095946312,
0.03155802562832832,
0.017126278951764107,
0.014488833025097847,
0.03772348538041115,
0.0008370469440706074,
-0.0020794158335775137,
0.028726480901241302,
0.01275336928665638,
-0.007158785127103329,
-0.002664563711732626,
0.020300351083278656,
0.002965700812637806,
0.03359034284949303,
-0.0432952344417572,
-0.004803921561688185,
-0.0022663776762783527,
-0.025461070239543915,
-0.005982780363410711,
-0.011565947905182838,
-0.0028814966790378094,
0.014363240450620651,
0.0006711360765621066,
-0.01774282567203045,
0.01615579053759575,
-0.032402921468019485,
-0.008939918130636215,
-0.015356563962996006,
0.013495508581399918,
-0.007175911217927933,
0.005851478781551123,
-0.009624969214200974,
0.004518483299762011,
0.0060798292979598045,
0.018439294770359993,
0.011828550137579441,
-0.024479161947965622,
-0.0013394177658483386,
0.02040310762822628,
-0.0362163744866848,
0.01020155381411314,
-0.013073060661554337,
-0.0027344960253685713,
-0.009396619163453579,
-0.02683117240667343,
-0.025940604507923126,
0.016087286174297333,
-0.005443302448838949,
0.012730535119771957,
-0.014979786239564419,
-0.010041709057986736,
0.029228851199150085,
0.023794110864400864,
-0.0020751343108713627,
0.022892126813530922
] | 2025-01-10 | 102 | 39791742 | [
"different molecular engineering platforms",
"acute lymphoblastic leukemia",
"certain hematological malignancies",
"non-Hodgkin lymphomas",
"non-Hodgkin",
"other hematological and non-hematological pathologies",
"acute myeloid",
"autoimmune diseases",
"hematological B-cell diseases",
"clinical studies",
"solid tumors",
"results",
"pathologies",
"multiple myeloma",
"acute T-lymphoid leukemia",
"B-cell derivations",
"CAR-T cells",
"strategies",
"infections",
"myeloid",
"limitations",
"CAR-T",
"The clinical application",
"the CAR-T application",
"this innovative treatment",
"a significant portion",
"the results",
"the setting",
"these settings",
"an overview"
] | [
"CAR-T in hematology",
"CAR-T in solid neoplasia",
"infectious and autoimmune disease",
"tumor immunosuppression",
"tumor microenvironment"
] | 0 | 10.3390/cells14010041
10.1056/NEJMoa1707447
10.1056/NEJMoa1709866
10.1016/S0140-6736(21)01222-8
10.1016/S0140-6736(20)31366-0
10.1056/NEJMoa1817226
10.1111/imr.12126
10.1016/j.jocit.2016.08.001
10.1016/j.annonc.2021.12.003
10.1182/blood.2019001463
10.1016/j.tranon.2020.100838
10.1038/mt.2014.164
10.1038/s41375-017-0008-6
10.1038/s41375-021-01232-2
10.1089/hum.2017.241
10.1136/jitc-2021-003149
10.1016/j.ymthe.2019.04.010
10.1182/blood-2016-08-736041
10.3390/cancers13194785
10.1182/blood-2007-03-083048
10.1016/j.ymthe.2017.05.024
10.1016/j.bbmt.2018.12.470
10.3892/mmr.2021.11847
10.1186/s13045-018-0603-7
10.3390/biomedicines10102441
10.3390/cancers14051164
10.1016/j.ymthe.2020.06.022
10.1182/blood.V77.7.1546.1546
10.1038/s41591-024-03228-8
10.1038/s41571-021-00556-3
10.1200/JCO.2024.42.16_suppl.6515
10.1007/s12015-019-09876-5
10.1136/jitc-2022-005333
10.1186/s13045-021-01178-z
10.1186/s12943-023-01723-z
10.1186/s12935-024-03315-3
10.1089/10430340260355374
10.1097/CJI.0b013e3181ee6675
10.1158/0008-5472.CAN-12-3913
10.1126/scitranslmed.abg3072
10.1080/07388551.2021.1988509
10.1016/j.celrep.2017.11.063
10.1038/s41467-021-26352-2
10.1172/jci.insight.133977
10.1158/2326-6066.CIR-15-0230
10.1016/j.ccell.2021.06.012
10.1126/scitranslmed.abh0272
10.1016/j.cell.2021.11.015
10.3390/cancers12071969
10.1073/pnas.1610544113
10.3389/fonc.2020.00262
10.3390/ijms24044197
10.1038/35052073
10.1038/s41571-019-0268-3
10.3390/cancers13112748
10.1016/j.omto.2023.100728
10.1016/j.lungcan.2011.11.012
10.1016/j.talanta.2021.123146
10.1088/1748-605X/abe359
10.3892/ol.2019.10935
10.1080/2162402X.2016.1251539
10.1080/2162402X.2021.1899469
10.1097/00000478-200311000-00003
10.1016/j.pharmthera.2020.107709
10.3390/cancers15051357
10.1182/blood.2021014760
10.3389/fonc.2012.00034
10.3390/ijms22116145
10.3390/biom9080311
10.1074/jbc.M109.087791
10.1002/pbc.26097
10.1007/s10719-015-9606-6
10.3390/ijms22126567
10.1371/journal.pone.0125994
10.3389/fendo.2018.00483
10.1038/nrc2780
10.1016/j.trecan.2018.09.004
10.1038/s41573-019-0052-1
10.7554/eLife.49392
10.1038/s41586-019-1311-3
10.4161/onci.26618
10.1016/j.omto.2022.10.011
10.3389/fonc.2021.720501
10.3389/fimmu.2022.953849
10.3389/fimmu.2022.841107
10.1038/s41568-020-0259-9
10.3389/fonc.2023.1103149
10.3390/ijms22136995
10.3390/cancers14143331
10.1038/nrdp.2015.35
10.1038/s41591-020-1039-5
10.1016/S1470-2045(23)00649-6
10.1038/nrc.2016.92
10.1136/jitc-2020-000736
10.1016/j.omto.2020.08.005
10.1038/s41579-021-00582-z
10.1128/JVI.02117-09
10.1093/infdis/jiaa171
10.1136/gutjnl-2014-308316
10.1053/j.gastro.2007.11.002
10.1016/j.ymthe.2019.02.001
10.1016/j.cell.2021.01.007
10.1016/j.isci.2021.103295
10.1038/s41573-019-0051-2
10.1056/NEJMoa2308917 | [
"Canichella",
"de Fabritiis"
] | [
"Hematology, St. Eugenio Hospital, ASL Roma2, 00144 Rome, Italy.",
"Hematology, St. Eugenio Hospital, ASL Roma2, 00144 Rome, Italy.\nDepartment of Biomedicina e Prevenzione, Tor Vergata University, 00133 Rome, Italy."
] | [
"39791742",
"29226797",
"29385370",
"34097852",
"32888407",
"31042825",
"24329792",
"34923107",
"31697826",
"32745961",
"25174587",
"29479065",
"33833386",
"29409351",
"34531250",
"31043341",
"28246194",
"34638268",
"17609428",
"28676343",
"33495835",
"29716633",
"36289703",
"35267471",
"32592688",
"1826223",
"39227445",
"34580474",
"30826931",
"36564128",
"34627328",
"36717905",
"38622705",
"12427307",
"20842059",
"23633494",
"35044789",
"34957875",
"29241547",
"34711823",
"31999649",
"27549124",
"34256903",
"34788079",
"34890549",
"32698361",
"27849617",
"32185132",
"36835603",
"11252954",
"31548601",
"34206026",
"37822488",
"22153832",
"34942484",
"33540396",
"31788040",
"28123893",
"33796409",
"14576474",
"33091428",
"36900151",
"35580162",
"22655270",
"34200284",
"31357634",
"20581115",
"27304202",
"26239922",
"34207342",
"25951175",
"30197623",
"20094046",
"30352677",
"31907401",
"32228854",
"31217581",
"24404430",
"36420307",
"34422667",
"35990652",
"35185932",
"32265522",
"36816959",
"34209703",
"35884391",
"27188527",
"32868878",
"38309282",
"27687982",
"33127653",
"32953984",
"34168328",
"20147393",
"32285133",
"25661083",
"18166356",
"30852138",
"33497610",
"34693218",
"31900462",
"38381673"
] | [] | 6.807213 | 6.533801 |
39791458 | 50 | Frontline immunotherapeutic combination strategies in adult B-cell acute lymphoblastic leukemia: reducing chemotherapy intensity and toxicity and harnessing efficacy. | Using immunotherapeutic agents like inotuzumab ozogamicin (InO), blinatumomab, or chimeric antigen receptor T (CAR T)-cell therapy in frontline adult B-cell acute lymphoblastic leukemia (B-ALL) therapy is promising. These agents are mostly well tolerated and have different toxicity profiles than conventional chemotherapy, enabling their combination with chemotherapy. Additionally, they have often been shown to overcome the traditional adverse ALL risk features. Recently blinatumomab was approved as part of consolidation therapy in MRD negative B-ALL; however, a significant proportion of patients had progressed or relapsed before reaching the timepoint of blinatumomab administration. Including InO/blinatumomab from induction onwards could induce earlier and deeper remissions. Modifications of dosing and administration schedules, as with the fractionated InO schedule with low-intensity chemotherapy, and subcutaneous blinatumomab, appear to reduce the toxicity and improve the anti-ALL efficacy. CAR T-cell therapies like brexucabtagene autoleucel as a consolidation approach have shown positive outcomes. The feasibility of using CAR T-cells to reduce the need for long-drawn maintenance and the need for allogeneic hematopoietic stem cell transplantation (HSCT) are questions of ongoing clinical trials. Newer generation CAR T-cell products like obecabtagene autoleucel appear as effective and safer. Better disease monitoring through next generation sequencing based measurable residual disease analysis could identify patients where treatment intensification including HSCT, or deintensification, is suitable. | [
0.005498818587511778,
0.023872919380664825,
0.0651567354798317,
0.0862741470336914,
-0.0252628643065691,
-0.029237620532512665,
0.031578581780195236,
0.027286820113658905,
0.011851112358272076,
-0.006492507643997669,
0.0027311204466968775,
-0.013448330573737621,
-0.03977194428443909,
0.023653455078601837,
0.04116188734769821,
-0.009363842196762562,
0.02721366472542286,
-0.00976619403809309,
0.01587463729083538,
0.050720810890197754,
0.021397842094302177,
0.02672596462070942,
0.015265013091266155,
-0.010900096967816353,
-0.021678268909454346,
-0.0365043506026268,
-0.011460952460765839,
0.0013533678138628602,
-0.0044959853403270245,
-0.03652873635292053,
0.010644054971635342,
-0.013082555495202541,
-0.027506286278367043,
-0.0004366439825389534,
-0.006504700053483248,
0.028164681047201157,
0.03416339308023453,
0.001926415367051959,
0.01569174975156784,
-0.04184466972947121,
0.0222147386521101,
-0.010003948584198952,
0.05852401256561279,
0.06949726492166519,
-0.0443563237786293,
-0.0024887945037335157,
-0.03421216085553169,
-0.0498429499566555,
0.018422871828079224,
-0.014167687855660915,
-0.0024842224083840847,
0.023848535493016243,
-0.006038337014615536,
0.03348061069846153,
-0.07081405073404312,
0.026555269956588745,
-0.00927849393337965,
0.013740950264036655,
-0.025823719799518585,
-0.0044136857613921165,
-0.008662773296236992,
0.001956896623596549,
0.02565302513539791,
-0.008900526911020279,
-0.03930862620472908,
-0.010997637175023556,
-0.04835546389222145,
-0.044746484607458115,
-0.00046369610936380923,
-0.011271968483924866,
-0.006504700053483248,
-0.035943496972322464,
-0.007370367646217346,
0.010394108481705189,
0.016703728586435318,
0.02290971204638481,
0.034724246710538864,
0.024019230157136917,
-0.015155280940234661,
-0.01494800765067339,
0.02882307581603527,
-0.0019889019895344973,
0.02351933717727661,
-0.030481256544589996,
-0.004706305917352438,
0.04116188734769821,
-0.011570684611797333,
0.003130425000563264,
-0.021617306396365166,
-0.0009342504781670868,
-0.03979632630944252,
-0.0008710019174031913,
-0.061596523970365524,
0.028774306178092957,
-0.007364271674305201,
-0.002536040497943759,
-0.009479670785367489,
-0.03979632630944252,
0.040357183665037155,
0.034480396658182144,
0.03506563603878021,
0.007217961363494396,
0.011832823976874352,
-0.028749920427799225,
0.04430755227804184,
-0.0011361888609826565,
-0.04045472294092178,
0.0030008796602487564,
0.018776454031467438,
-0.002507083350792527,
0.04481963813304901,
-0.014192072674632072,
-0.0316273495554924,
0.043673545122146606,
-0.034602321684360504,
-0.08471350371837616,
-0.028774306178092957,
-0.012789934873580933,
0.012485122308135033,
0.01636233739554882,
0.0033559862058609724,
0.029944786801934242,
0.02757943980395794,
-0.024055806919932365,
-0.029481470584869385,
-0.025921260938048363,
0.07047266513109207,
-0.032895371317863464,
-0.027555055916309357,
-0.07866602391004562,
0.026408961042761803,
-0.012863090261816978,
-0.0030786069110035896,
-0.017666935920715332,
-0.07778816670179367,
-0.00936993770301342,
-0.006699780002236366,
-0.019861586391925812,
-0.043307770043611526,
-0.01129025686532259,
0.028896231204271317,
0.0021580730099231005,
-0.028530456125736237,
-0.012533892877399921,
-0.0522814504802227,
-0.0270917396992445,
0.0231291763484478,
-0.013594640418887138,
0.032310131937265396,
0.04055226221680641,
-0.033748846501111984,
0.05681706219911575,
0.03455355018377304,
0.017045117914676666,
0.0200810506939888,
-0.045843809843063354,
-0.01494800765067339,
0.06432764232158661,
-0.028871845453977585,
-0.06618089973926544,
0.013411752879619598,
-0.0021870301570743322,
-0.01275335717946291,
-0.051696211099624634,
0.027140511199831963,
-0.016825653612613678,
-0.006699780002236366,
0.04552680253982544,
-0.056719522923231125,
0.021531959995627403,
-0.00495930016040802,
-0.005745716858655214,
-0.053305622190237045,
-0.03977194428443909,
-0.028603611513972282,
-0.006401063874363899,
0.011863305233418941,
0.002251040656119585,
-0.025482330471277237,
-0.017508434131741524,
0.04396616294980049,
0.007931223139166832,
0.03306606784462929,
-0.016020948067307472,
-0.04601450264453888,
0.03747975081205368,
-0.033773232251405716,
0.040479108691215515,
-0.06218176335096359,
0.00002807609416777268,
-0.0045874291099607944,
-0.003971707541495562,
0.00979667529463768,
0.03782114386558533,
0.02501901425421238,
-0.007711757905781269,
0.04196659475564957,
0.02355591394007206,
-0.049379635602235794,
-0.01995912566781044,
0.017545010894536972,
-0.005318979267030954,
-0.016459878534078598,
-0.0027417889796197414,
-0.028969386592507362,
0.01593559980392456,
-0.020178591832518578,
0.04006456211209297,
0.006358390208333731,
-0.028506070375442505,
0.0026107195299118757,
-0.01022341288626194,
-0.03348061069846153,
0.03808937594294548,
-0.028993770480155945,
-0.016618380323052406,
-0.020459018647670746,
0.03489494323730469,
0.008827371522784233,
-0.0002787129778880626,
0.029018156230449677,
-0.024153348058462143,
-0.023446181789040565,
0.05457364022731781,
-0.04116188734769821,
-0.0019050785340368748,
0.006833897437900305,
-0.002871334319934249,
-0.015399130992591381,
-0.01089400053024292,
-0.017362123355269432,
-0.016289183869957924,
0.006129780784249306,
0.01873987540602684,
-0.009723520837724209,
-0.01378971990197897,
0.02575056441128254,
0.01025389414280653,
0.08198238909244537,
-0.034236546605825424,
-0.019081266596913338,
0.009132184088230133,
0.0016307472251355648,
-0.027311205863952637,
-0.023726610466837883,
-0.006401063874363899,
-0.015959985554218292,
-0.0888589546084404,
-0.0022601850796490908,
-0.008924911729991436,
-0.04350284859538078,
-0.001656656269915402,
-0.007559351623058319,
-0.04872123897075653,
0.025311635807156563,
0.004791653249412775,
0.05164743959903717,
-0.042429909110069275,
-0.02199527435004711,
-0.008711542934179306,
0.0006862092996016145,
0.016472071409225464,
-0.02400703728199005,
-0.041990976780653,
-0.03940616920590401,
0.05164743959903717,
0.0037430983502417803,
0.02967655099928379,
0.03140788525342941,
0.01531378272920847,
-0.013984800316393375,
-0.0009235820616595447,
0.047428835183382034,
-0.044136859476566315,
-0.03296852484345436,
-0.021349072456359863,
0.013436137698590755,
0.022251317277550697,
-0.015386938117444515,
0.035358257591724396,
-0.006004807539284229,
-0.03274906054139137,
-0.008047051727771759,
-0.028530456125736237,
-0.013070362620055676,
-0.0003514869895298034,
-0.020105436444282532,
-0.011265872046351433,
0.0002312765282113105,
-0.01214373204857111,
0.003074034582823515,
-0.018276561051607132,
0.01336298231035471,
-0.028164681047201157,
-0.0008694778080098331,
-0.018032710999250412,
-0.00848598126322031,
-0.02032490074634552,
-0.0045660920441150665,
0.036309272050857544,
-0.007077747490257025,
0.023836342617869377,
-0.03879654407501221,
-0.05189128965139389,
0.04701428860425949,
0.04484402388334274,
-0.017228005453944206,
0.000012299663467274513,
0.039967022836208344,
0.05252530053257942,
0.025092169642448425,
0.013167902827262878,
0.016874423250555992,
-0.009632077068090439,
0.015679558739066124,
-0.03452916815876961,
0.003883311990648508,
-0.0590604804456234,
-0.006184646859765053,
-0.02650650031864643,
-0.004233846440911293,
-0.02614072524011135,
-0.03786991164088249,
0.003974755760282278,
-0.005861545447260141,
-0.026555269956588745,
0.0013282207073643804,
0.0010302664013579488,
0.011028118431568146,
-0.037674833089113235,
-0.016337953507900238,
-0.006468122359365225,
0.09193146973848343,
-0.01385068241506815,
0.006309620104730129,
0.012210790999233723,
0.00997956283390522,
-0.08534751832485199,
0.02459227666258812,
0.0197762381285429,
-0.019629929214715958,
0.029871631413698196,
-0.049891721457242966,
0.02879869006574154,
-0.0103453379124403,
-0.012826512567698956,
-0.010058814659714699,
0.03979632630944252,
-0.018337523564696312,
0.03238328546285629,
0.0010135017801076174,
-0.030091095715761185,
0.022470781579613686,
-0.015484478324651718,
0.0041058249771595,
0.06227930262684822,
-0.045624345541000366,
-0.01971527561545372,
-0.014118918217718601,
0.013838490471243858,
0.007528870366513729,
-0.020556559786200523,
-0.04898947477340698,
0.043283384293317795,
0.05101342871785164,
0.06408379226922989,
0.0014318570028990507,
0.009010259062051773,
-0.038772158324718475,
-0.01910565048456192,
0.005575021728873253,
-0.007864164188504219,
0.019130036234855652,
0.02306821383535862,
-0.015460093505680561,
0.06598582118749619,
0.011765765026211739,
0.015399130992591381,
0.023909498006105423,
0.03526071831583977,
0.021190568804740906,
-0.0010843706550076604,
0.005754861049354076,
-0.0036760393995791674,
-0.014082340523600578,
0.01849602535367012,
0.00559940654784441,
-0.03626050055027008,
-0.0554027296602726,
0.03404146805405617,
0.006785127799957991,
-0.008199458010494709,
0.02297067455947399,
-0.01569174975156784,
-0.023897305130958557,
0.08798109740018845,
-0.03355376794934273,
0.10817188024520874,
0.02254393696784973,
0.01281431969255209,
-0.0028073235880583525,
-0.0426006019115448,
-0.018118059262633324,
-0.07871479541063309,
0.008071436546742916,
-0.027042970061302185,
0.010534321889281273,
0.001595693756826222,
0.02965216524899006,
-0.03989386931061745,
-0.007260635029524565,
0.05018433928489685,
0.04433193802833557,
-0.025189710780978203,
0.028018370270729065,
-0.028262220323085785,
-0.05154990032315254,
0.06179160252213478,
-0.034114621579647064,
0.06359609216451645,
0.03296852484345436,
-0.003669943194836378,
0.03111526556313038,
-0.02437281236052513,
-0.006541277747601271,
0.016289183869957924,
0.030432486906647682,
0.01500897016376257,
-0.002415639581158757,
-0.03138349950313568,
-0.008894430473446846,
0.09334579855203629,
-0.020117629319429398,
-0.03977194428443909,
-0.014435922726988792,
0.017508434131741524,
-0.021861156448721886,
0.014009185135364532,
-0.002597003011032939,
-0.01348490733653307,
-0.010083199478685856,
0.014070147648453712,
0.012558277696371078,
-0.025067785754799843,
-0.013594640418887138,
-0.007961704395711422,
-0.02748190052807331,
0.04235675185918808,
-0.05949941277503967,
0.0014783409424126148,
0.0047489795833826065,
-0.00578229408711195,
-0.006093203090131283,
0.009699136018753052,
-0.019008111208677292,
-0.013436137698590755,
0.018544796854257584,
-0.04152766242623329,
0.013838490471243858,
0.032651521265506744,
0.04043033719062805,
-0.026945430785417557,
0.01587463729083538,
-0.047428835183382034,
-0.019642122089862823,
0.02392168901860714,
0.04333215206861496,
-0.010509937070310116,
0.019434848800301552,
-0.040601033717393875,
0.021824579685926437,
-0.005879834294319153,
-0.025921260938048363,
0.01904468797147274,
0.008711542934179306,
0.034626707434654236,
0.017983941361308098,
0.015740521252155304,
0.02806713990867138,
0.021470997482538223,
0.009845445863902569,
0.010266087017953396,
-0.033529382199048996,
-0.03491932526230812,
0.04106434807181358,
0.0307494904845953,
-0.0002143213350791484,
-0.004416733980178833,
-0.045990120619535446,
0.009686943143606186,
0.011710898950695992,
-0.002200746675953269,
0.02735997550189495,
-0.01132073812186718,
-0.011729187332093716,
-0.029749706387519836,
-0.026408961042761803,
-0.00572133157402277,
0.008778601884841919,
-0.00514218769967556,
0.0029902111273258924,
0.00903464388102293,
0.012826512567698956,
0.0012649721466004848,
0.04240552335977554,
0.003968659322708845,
0.0029140079859644175,
0.02166607603430748,
-0.024567892774939537,
0.00014964392175897956,
-0.03713836148381233,
-0.051842521876096725,
0.02379976399242878,
-0.0030420294497162104,
-0.0474776029586792,
-0.027993986383080482,
-0.055012572556734085,
-0.018691105768084526,
0.0050537921488285065,
-0.006090154871344566,
-0.05496380105614662,
0.030603181570768356,
0.002744837198406458,
-0.02303163707256317,
0.029603395611047745,
-0.007089940365403891,
-0.028237836435437202,
-0.022202547639608383,
-0.029091311618685722,
-0.018118059262633324,
0.020300516858696938,
-0.016935385763645172,
-0.002973446622490883,
0.019032496958971024,
-0.009150473400950432,
-0.002583286492154002,
-0.018264368176460266,
0.033895157277584076,
-0.01685003750026226,
-0.027262436226010323,
0.016252605244517326,
0.0051452359184622765,
0.008004377596080303,
-0.005571973510086536,
0.009083414450287819,
0.01366779487580061,
0.016996348276734352,
-0.018471641466021538,
-0.0013206003932282329,
-0.018471641466021538,
0.04338092356920242,
-0.019190998747944832,
-0.007260635029524565,
-0.018032710999250412,
0.03099334053695202,
-0.008595714345574379,
-0.03982071205973625,
-0.012070577591657639,
0.0018075384432449937,
-0.013862875290215015,
-0.022068429738283157,
-0.025092169642448425,
0.005230583716183901,
-0.030700720846652985,
-0.0043832045048475266,
0.017069503664970398,
-0.0118694007396698,
-0.006809512618929148,
-0.025970030575990677,
0.03928424417972565,
-0.02162949927151203,
0.007504485081881285,
-0.015265013091266155,
-0.011375605128705502,
0.021678268909454346,
0.017081696540117264,
0.00988811906427145,
0.02077602408826351,
-0.0191666129976511,
-0.00045607579522766173,
-0.015862446278333664,
-0.026921045035123825,
-0.035236332565546036,
0.04957471415400505,
-0.007553255185484886,
0.03689451143145561,
-0.04484402388334274,
0.015325975604355335,
-0.0027174039278179407,
-0.0042978571727871895,
0.048916321247816086,
-0.000874050019774586,
0.027384361252188683,
0.011588973924517632,
-0.04184466972947121,
0.012582662515342236,
0.011948652565479279,
0.0106501504778862,
-0.02138564921915531,
-0.0003707282885443419,
-0.0005738096660934389,
-0.012027903459966183,
-0.0003088132361881435,
-0.004492937121540308,
-0.02477516420185566,
0.038162533193826675,
-0.0022556129842996597,
-0.005419567227363586,
-0.013984800316393375,
0.006998496595770121,
0.04667289927601814,
0.03735782578587532,
-0.00885175634175539,
0.0106501504778862,
0.027555055916309357,
0.02857922576367855,
-0.01470415759831667,
0.0014973917277529836,
0.042307984083890915,
-0.013436137698590755,
-0.021349072456359863,
-0.00012449687346816063,
-0.0029094358906149864,
-0.002862189896404743,
0.0046422951854765415,
-0.03799183666706085,
-0.009211435914039612,
-0.010765979997813702,
0.054037172347307205,
0.0033864674624055624,
-0.017788860946893692,
-0.024848319590091705,
-0.011302449740469456,
0.04325899854302406,
-0.033626921474933624,
-0.041576433926820755,
0.06408379226922989,
-0.006135876756161451,
0.00128554692491889,
0.010942771099507809,
-0.0283109899610281,
0.016264798119664192,
-0.0003133854188490659,
-0.033773232251405716,
0.022629285231232643,
-0.02093452587723732,
-0.03952809423208237,
-0.004968444816768169,
-0.015545440837740898,
-0.009394323453307152,
-0.0042917607352137566,
-0.045868195593357086,
0.04662412777543068,
-0.014057955704629421,
0.010534321889281273,
-0.03647996857762337,
0.01211325079202652,
0.0013663222780451179,
0.05901171267032623,
0.05569535121321678,
-0.035480182617902756,
0.013692180626094341,
-0.010814749635756016,
0.0005959085538052022,
-0.006233416963368654,
-0.004325290210545063,
0.006943630054593086,
-0.013021592982113361,
0.02589687518775463,
0.009869830682873726,
0.0881761759519577,
0.02443377487361431,
-0.0026183398440480232,
-0.004852615762501955,
-0.007687372621148825,
0.011357315815985203,
0.012088865973055363,
-0.008522558957338333,
-0.04789214953780174,
0.02867676503956318,
-0.036943282932043076,
-0.0040082852356135845,
-0.013826297596096992,
-0.03774798661470413,
-0.013082555495202541,
0.01293624471873045,
0.02331206388771534,
-0.018142443150281906,
-0.0021870301570743322,
-0.013960415497422218,
0.01446030754595995,
-0.023482760414481163,
-0.00936993770301342,
0.019508004188537598,
0.0200810506939888,
0.01989816315472126,
-0.0019187950529158115,
-0.011204909533262253,
-0.038625847548246384,
-0.036187347024679184,
0.05384209007024765,
-0.010583092458546162,
0.048526160418987274,
-0.02977409027516842,
-0.003343793796375394,
-0.007949511520564556,
0.012424159795045853,
0.000025289917175541632,
0.008918815292418003,
0.03357814997434616,
0.01141218189150095,
0.0234339889138937,
-0.025677410885691643,
-0.009168761782348156,
0.0012558277230709791,
0.01061966922134161,
-0.005611599422991276,
0.05286668986082077,
0.0046636322513222694,
0.003822349477559328,
0.0016536081675440073,
0.0252628643065691,
-0.03845515102148056,
-0.0004949393915012479,
0.04542926326394081,
0.03491932526230812,
-0.026701580733060837,
0.05393962934613228,
-0.015972178429365158,
-0.013265443034470081,
-0.01293624471873045,
-0.02337302640080452,
-0.02022736147046089,
-0.016252605244517326,
-0.031090881675481796,
0.060377273708581924,
-0.011387797072529793,
-0.025604255497455597,
0.016776883974671364,
-0.013692180626094341,
0.0222147386521101,
-0.043893009424209595,
-0.049891721457242966,
-0.0038863602094352245,
0.008467692881822586,
-0.008845660835504532,
0.02193431183695793,
-0.0009449189528822899,
-0.018410678952932358,
-0.0017008540453389287,
0.00045874289935454726,
0.009424804709851742,
-0.018203405663371086,
-0.0009068173822015524,
-0.028969386592507362,
-0.04150327667593956,
0.007894645445048809,
-0.009150473400950432,
-0.04750198870897293,
-0.018081480637192726,
-0.002720452146604657,
0.007199672516435385,
-0.013862875290215015,
-0.019861586391925812,
-0.013631218113005161,
0.007047266233712435,
0.0042368946596980095,
0.004310049582272768,
0.012521700002253056,
0.0007692707004025578,
-0.025336019694805145,
-0.014752928167581558,
0.038162533193826675,
0.0031852913089096546,
0.0013015496078878641,
0.033285532146692276,
-0.029335161671042442,
0.015265013091266155,
-0.002196174580603838,
0.016045333817601204,
-0.004508177749812603,
0.016496455296874046,
-0.000010477931937202811,
0.03262713551521301,
-0.017679128795862198,
0.011735283769667149,
0.010302664712071419,
0.03616296127438545,
-0.01348490733653307,
-0.00566036906093359,
-0.013582447543740273,
0.032773446291685104,
-0.02473858743906021,
0.02321452461183071,
0.0007018308970145881,
0.006266946438699961,
0.03455355018377304,
-0.0742279514670372,
-0.0079068373888731,
-0.04896508902311325,
-0.03721151873469353,
-0.03952809423208237,
0.041576433926820755,
-0.03882092610001564,
0.00005996234540361911,
0.001459290157072246,
-0.006955822464078665,
0.01385068241506815,
-0.04113750159740448,
0.02514093928039074,
-0.01519185770303011,
-0.009040740318596363,
-0.020483404397964478,
0.010936674661934376,
-0.04577065259218216,
-0.007717853877693415,
0.016264798119664192,
0.005928604397922754,
0.000052103896450717,
-0.02187334932386875,
0.03587034344673157,
-0.006364486180245876,
-0.0103453379124403,
-0.0025131795555353165,
-0.013862875290215015,
-0.02248297445476055,
0.005663417279720306,
0.012283946387469769,
0.039747558534145355,
-0.010662343353033066,
0.0161184873431921,
0.006797320209443569,
-0.03967440128326416,
0.01941046305000782,
0.024421581998467445,
0.005440904293209314,
0.007833682931959629,
-0.006870475132018328,
0.007035073824226856,
0.011674321256577969,
-0.006129780784249306,
-0.037284672260284424,
-0.004285664763301611,
-0.030334945768117905,
0.0018715491751208901,
0.0371139757335186,
-0.031700506806373596,
-0.010973252356052399,
-0.030822645872831345,
-0.02400703728199005,
0.004800797905772924,
-0.022678054869174957,
-0.003956466913223267,
-0.026921045035123825,
0.010509937070310116,
-0.000551329692825675,
-0.003160906257107854,
-0.005913363769650459,
0.05954818055033684,
0.02550671435892582,
-0.02928639017045498,
0.006833897437900305,
-0.02843291498720646,
-0.04479525238275528,
0.019422655925154686,
-0.059158023446798325,
0.002653393428772688,
0.0013358410215005279,
-0.0002933820942416787,
-0.06652229279279709,
0.0246532391756773,
0.018483834341168404,
0.0047947014681994915,
0.00037339539267122746,
0.0026366286911070347,
-0.011241487227380276,
0.007345982827246189,
-0.017874209210276604,
-0.0059347003698349,
0.0015240628272294998,
0.012485122308135033,
-0.022751210257411003,
-0.018776454031467438,
-0.0077910092659294605,
0.014862660318613052,
0.012582662515342236,
0.009455285966396332,
-0.017496241256594658,
-0.00997956283390522,
0.009900311939418316,
0.018471641466021538,
-0.02217816188931465,
-0.0020574848167598248,
-0.03382200002670288,
0.0006926865316927433,
0.005108658690005541,
-0.00492881890386343,
0.025311635807156563,
-0.04545364901423454,
0.03184681758284569,
-0.02794521488249302,
0.0018227790715172887,
-0.014070147648453712,
0.015167472884058952,
-0.01739870011806488,
0.00927849393337965,
-0.036089807748794556,
0.030188636854290962,
-0.02245858870446682,
0.03455355018377304,
0.0050233108922839165,
-0.019215384498238564,
0.009199243038892746,
0.03026179037988186,
-0.043161459267139435,
0.017727898433804512,
0.010808653198182583,
0.0681317001581192,
0.029481470584869385,
-0.0022525647655129433,
-0.026774736121296883,
-0.004843471571803093,
-0.017545010894536972,
0.00016088387928903103,
0.012802127748727798,
-0.01800832524895668,
0.022434204816818237,
0.02154415100812912,
0.006596143823117018,
-0.016264798119664192,
-0.017874209210276604,
-0.024141155183315277,
0.00043016672134399414,
0.013033784925937653,
0.0015271109296008945,
-0.0007239298429340124,
0.04386862367391586,
-0.025701794773340225,
-0.017862016335129738,
0.0005448524607345462,
0.008528655394911766,
0.012594855390489101,
-0.01482608262449503,
-0.046355895698070526,
0.016740305349230766,
-0.02126372419297695,
0.015569825656712055,
-0.01819121278822422,
0.0322369746863842,
0.016386723145842552,
0.06666859984397888,
0.003700424451380968,
0.02333644963800907,
0.0022830460220575333,
-0.031310345977544785,
-0.03638242557644844,
0.015862446278333664,
-0.01770351268351078,
0.03174927458167076,
-0.012655817903578281,
-0.06598582118749619,
-0.019934741780161858,
-0.00608710665255785,
-0.009540633298456669,
-0.007254539057612419,
-0.0017694368725642562,
0.028506070375442505,
0.010583092458546162,
-0.05506134033203125,
0.029213236644864082,
-0.022312279790639877,
-0.014313997700810432,
-0.00827261246740818,
0.025457944720983505,
0.008839564397931099,
0.029262006282806396,
0.021763617172837257,
-0.006340101361274719,
0.006833897437900305,
0.007443522568792105,
0.0036882320418953896,
0.027286820113658905,
-0.022556129842996597,
-0.033870771527290344,
-0.001392231322824955,
0.046355895698070526,
-0.020824793726205826,
-0.0014173784293234348,
-0.006888763979077339,
0.01587463729083538,
0.05003802850842476,
0.013899452984333038,
-0.01739870011806488,
-0.0322369746863842,
0.006590047385543585,
-0.03394392505288124,
-0.0316273495554924,
-0.055500272661447525,
0.03674820065498352,
0.05515887960791588,
-0.008937104605138302,
-0.02516532503068447,
0.022080622613430023,
-0.006315716076642275,
-0.028237836435437202,
0.011881593614816666,
0.05311053991317749,
-0.002993259346112609,
0.03367569297552109,
-0.03843076899647713,
0.029993556439876556,
0.03004232607781887,
-0.00523363146930933,
0.01174747571349144,
-0.018386293202638626,
-0.0237388014793396,
0.0004164501733612269,
-0.03174927458167076,
-0.051208510994911194,
0.020910141989588737,
-0.0006934485863894224,
0.006175502669066191,
-0.003365130629390478,
0.046941135078668594,
0.0413813516497612,
-0.01421645749360323,
0.02108083665370941,
-0.02138564921915531,
0.029969170689582825,
0.02136126346886158,
0.004630102775990963,
-0.019727468490600586,
0.010522129945456982,
-0.0014768168330192566,
-0.015143088065087795,
-0.013131325133144855,
0.0012322047259658575,
0.0663759857416153,
0.007010689005255699,
-0.006894859950989485,
-0.025457944720983505,
-0.015240628272294998,
0.0001428808900527656,
0.040722958743572235,
-0.027311205863952637,
-0.017557203769683838,
-0.016435492783784866,
-0.03274906054139137,
-0.0022586609702557325,
0.049160171300172806,
0.0200810506939888,
0.03321237489581108,
0.006907052826136351,
0.0036455581430345774,
0.017605973407626152,
0.02614072524011135,
-0.006602240260690451,
-0.02120276167988777,
0.01867891289293766,
-0.006492507643997669,
0.014253035187721252,
-0.004401493351906538,
0.02833537571132183,
-0.0011003733379766345,
-0.025677410885691643,
0.021458804607391357,
0.005395182408392429,
0.016837846487760544,
-0.011113465763628483,
-0.012040096335113049,
-0.0049928296357393265,
-0.033407457172870636,
-0.02473858743906021,
0.03187119960784912,
-0.00808972492814064,
-0.017118273302912712,
0.0014752928400412202,
-0.001682565314695239,
0.019508004188537598,
-0.02117837592959404,
0.005666465498507023,
0.025482330471277237,
-0.012704587541520596,
-0.010138065554201603,
-0.02916446514427662,
-0.0030938475392758846,
-0.02333644963800907,
-0.02723805047571659,
0.030188636854290962,
-0.032407671213150024,
-0.006321812514215708,
-0.0009517772123217583,
-0.007022881414741278,
-0.021470997482538223,
-0.011973037384450436,
-0.0020056667272001505,
0.011241487227380276,
0.0004793177649844438,
0.010509937070310116,
-0.010796461254358292,
-0.013350790366530418,
-0.011399989947676659,
-0.024787357077002525,
-0.007961704395711422,
-0.019117843359708786,
0.02928639017045498,
-0.013204480521380901,
-0.03940616920590401,
0.05628059059381485,
-0.0009091034880839288,
-0.0185569878667593,
0.012094962410628796,
-0.007553255185484886,
0.005818871781229973,
0.02339741215109825,
-0.006279138848185539,
-0.012802127748727798,
0.01599656231701374,
0.028481686487793922,
0.006382775027304888,
-0.0014097581151872873,
-0.034358471632003784,
-0.007376464083790779,
0.0005448524607345462,
0.00480689387768507,
-0.0249580517411232,
-0.008589617908000946,
0.012290042825043201,
0.01211325079202652,
-0.019873779267072678,
-0.035821571946144104,
0.0043130978010594845,
0.0206906758248806,
0.00927849393337965,
-0.01150362566113472,
0.018337523564696312,
-0.01861795037984848,
-0.010369723662734032,
0.010851327329874039,
0.003365130629390478,
0.01177795697003603,
0.03879654407501221,
-0.016459878534078598,
-0.0029444892425090075,
-0.01849602535367012,
-0.0023363882210105658,
0.005157428327947855,
0.06647352129220963,
-0.006925341207534075,
-0.04203974828124046,
0.030456870794296265,
0.025336019694805145,
-0.014350575394928455,
0.017325546592473984,
-0.012027903459966183,
-0.0109549630433321,
0.014789505861699581,
-0.006455929949879646,
0.02867676503956318,
0.02906692586839199,
-0.041990976780653,
0.009107799269258976,
0.022446397691965103,
-0.020190784707665443,
0.0022403723560273647,
0.0045721884816884995,
0.003167002461850643,
0.004093632567673922,
0.032285746186971664,
-0.028871845453977585,
0.01782543770968914,
0.0024232598952949047,
0.009040740318596363,
0.06179160252213478,
0.029603395611047745,
0.015703942626714706,
0.03050564043223858,
-0.012533892877399921,
-0.007248442620038986,
-0.025116555392742157,
-0.013460522517561913,
-0.0016795172123238444,
-0.0240436140447855,
-0.01074159424751997,
-0.03384638577699661,
0.01880083791911602,
0.005245824344456196,
-0.009449189528822899,
0.016386723145842552,
-0.00043588195694610476,
0.007431330159306526,
-0.01587463729083538,
0.011454856023192406,
0.002735692774876952,
0.01965431310236454,
0.02467762492597103,
0.0007768910145387053,
-0.01599656231701374,
-0.004172883927822113,
0.009936889633536339,
-0.009363842196762562,
0.011771861463785172,
0.020361479371786118,
-0.006760742515325546,
0.026287036016583443,
0.010211220942437649,
0.010583092458546162,
-0.02992040105164051,
-0.035602107644081116,
-0.051208510994911194,
0.012405871413648129,
-0.02760382555425167,
-0.011515818536281586,
0.00044845548109151423,
0.002246468560770154,
-0.045599959790706635,
0.0036455581430345774,
-0.0003577737370505929,
-0.0012421112041920424,
-0.0022891422268003225,
0.017727898433804512,
-0.005340315867215395,
0.003258446231484413,
0.00550796277821064,
0.016508648172020912,
0.010814749635756016,
0.041698358952999115,
0.018349716439843178,
0.004111921414732933,
0.0010516033507883549,
0.013558062724769115,
-0.016679342836141586,
-0.007839779369533062,
0.018264368176460266,
0.02431184984743595,
-0.035114407539367676,
0.0023043828550726175,
0.0012131539406254888,
0.008461596444249153,
0.061352673918008804,
0.005486626178026199,
0.027433130890130997,
-0.007431330159306526,
-0.023056022822856903,
-0.033407457172870636,
0.017447471618652344,
0.012887475080788136,
0.03318799287080765,
0.02306821383535862,
-0.032066281884908676,
0.00793731864541769,
-0.017288967967033386,
-0.017142659053206444,
-0.04082049801945686,
-0.011521914973855019,
0.02748190052807331,
0.030188636854290962,
-0.0036425101570785046,
-0.0013076459290459752,
-0.02514093928039074,
0.024726394563913345,
0.00113314064219594,
0.011546299792826176,
0.005322027485817671,
-0.002464409451931715,
-0.0011765764793381095,
0.008540848270058632,
0.015179665759205818,
0.0045965733006596565,
0.009571114555001259,
0.016033140942454338,
0.007193576544523239,
-0.03126157447695732,
0.008650580421090126,
0.01031485665589571,
0.011253680102527142,
-0.013082555495202541,
-0.02422650158405304,
0.026652811095118523,
-0.01666714996099472,
-0.020849179476499557,
0.004477696493268013,
0.007053362671285868,
-0.021495381370186806,
-0.010064911097288132,
0.018971534445881844,
-0.0013861351180821657,
-0.006766838952898979,
-0.013753143139183521,
-0.02904254011809826,
-0.017996134236454964,
-0.04099119454622269,
0.008077532984316349,
-0.00818116869777441,
-0.030334945768117905,
0.008937104605138302,
0.005922507960349321,
-0.01898372545838356,
0.006699780002236366,
-0.011357315815985203,
-0.03296852484345436,
0.013996993191540241,
0.011406086385250092,
-0.019995704293251038,
-0.05081835016608238,
-0.0033376975916326046,
0.004599621519446373,
-0.0377236008644104,
-0.014838275499641895,
-0.004121065605431795,
0.011497530154883862,
0.05579289048910141,
-0.019447041675448418,
0.008205554448068142,
0.012040096335113049,
0.010156354866921902,
-0.018520411103963852,
0.020215168595314026,
0.010455070994794369,
0.010296568274497986,
-0.031066495925188065,
-0.025092169642448425,
-0.013679987750947475,
0.004364915657788515,
0.03306606784462929,
0.0022647574078291655,
-0.0042612794786691666,
0.013167902827262878,
-0.0206906758248806,
0.021349072456359863,
0.0021565489005297422,
-0.01648426242172718,
0.006846090313047171,
-0.012838705442845821,
-0.003212724346667528,
-0.014240843243896961,
0.004035718273371458,
-0.014618810266256332,
0.00529459398239851,
0.03196874260902405,
-0.023653455078601837,
0.02197088859975338,
-0.0046026697382330894,
0.0413813516497612,
-0.011973037384450436,
0.012430256232619286,
-0.010540418326854706,
0.04650220274925232,
-0.007620314136147499,
0.0011887690052390099,
0.0007178335799835622,
-0.013875068165361881,
-0.008205554448068142,
0.011857208795845509,
0.01001004409044981,
-0.031188420951366425,
0.013070362620055676,
-0.019971318542957306,
-0.01162555068731308,
0.0007947987760417163,
0.000032743537303758785,
0.01348490733653307,
-0.009619884192943573,
-0.0203858632594347,
0.02575056441128254,
-0.01470415759831667,
0.00830309372395277,
-0.023324256762862206,
0.0005852401372976601,
-0.004620958585292101,
0.020727254450321198,
-0.02425088733434677,
0.01563078723847866,
-0.002318099606782198,
-0.0025101313367486,
-0.01739870011806488,
-0.024482544511556625,
-0.01150362566113472,
-0.006974111311137676,
-0.025726180523633957,
0.006809512618929148,
-0.012521700002253056,
0.006888763979077339,
-0.027652595192193985,
-0.03296852484345436,
-0.003450478194281459,
-0.00232724379748106,
-0.01831313781440258,
-0.007358175236731768,
-0.035455796867609024,
-0.02203185111284256,
0.036187347024679184,
0.030213020741939545,
-0.009686943143606186,
-0.0005456144572235644,
-0.04372231289744377,
0.014057955704629421,
-0.01739870011806488,
0.03635804355144501,
-0.00802876241505146,
-0.020337093621492386,
0.0079068373888731,
-0.006766838952898979,
-0.03306606784462929,
-0.03245644271373749,
-0.04211290180683136,
0.005376893561333418,
0.00860790628939867,
0.014594425447285175,
0.02394607476890087,
0.017532818019390106,
-0.015350360423326492,
0.024360619485378265,
-0.04642904922366142,
0.0016383675392717123,
0.01519185770303011,
0.003959515132009983,
0.005163524765521288,
0.046697285026311874,
-0.007595928851515055,
0.005248872097581625,
-0.011497530154883862,
0.02940831519663334,
-0.03367569297552109,
-0.0029201044235378504,
0.010516033507883549,
-0.012619240209460258,
-0.020434634760022163,
0.027262436226010323,
-0.0076995654962956905,
-0.0283109899610281,
0.005370797123759985,
-0.016654958948493004,
-0.022446397691965103,
0.011802342720329762,
-0.034358471632003784,
0.00617855042219162,
-0.01092448178678751,
0.026043185964226723,
0.004002188798040152,
0.027798905968666077,
-0.04057664796710014,
0.0219099260866642,
-0.025945644825696945,
-0.039723172783851624,
-0.024811742827296257,
-0.006382775027304888,
-0.025970030575990677,
0.004294808954000473,
-0.0029703984037041664,
-0.007352078799158335,
0.026677194982767105,
0.013619025237858295,
-0.020068859681487083,
0.018081480637192726,
-0.02565302513539791,
-0.00936993770301342,
0.034236546605825424,
-0.011576781049370766,
-0.006388871464878321,
0.0295302402228117,
0.007809297647327185,
0.02473858743906021,
0.018520411103963852,
-0.005450048483908176,
0.004691065289080143,
0.017362123355269432,
-0.01324105728417635,
0.008626195602118969,
-0.021275917068123817,
-0.0021626451052725315,
0.07973896712064743,
-0.0030831790063530207,
0.0006374392542056739,
0.016593996435403824,
-0.019130036234855652,
0.017935171723365784,
0.01348490733653307,
0.021007681265473366,
0.04155204817652702,
-0.05554904043674469,
0.01543570775538683,
0.03626050055027008,
0.017264584079384804,
0.016581803560256958,
0.032675907015800476,
-0.019520197063684464,
-0.017508434131741524,
0.0438198521733284,
-0.01745966263115406,
-0.008229939267039299,
-0.011643840000033379,
0.018337523564696312,
-0.0222147386521101,
0.032846599817276,
-0.030554411932826042,
0.006340101361274719,
0.004559996072202921,
-0.003801012644544244,
-0.014179880730807781,
-0.016228221356868744,
0.021129606291651726,
0.009534536860883236,
0.032285746186971664,
-0.017106080427765846,
-0.005828015971928835,
-0.0030054517555981874,
-0.018093673512339592,
0.011588973924517632,
0.015606403350830078,
0.012741165235638618,
-0.015508863143622875,
0.008815179578959942,
0.006123684346675873,
0.01464319508522749,
0.010613573715090752,
0.0013045977102592587,
-0.0240436140447855,
-0.012850897386670113,
0.0018593566492199898,
-0.016447685658931732,
0.015703942626714706,
-0.00032500640372745693,
0.029481470584869385,
0.020239554345607758,
-0.016228221356868744,
-0.028237836435437202,
0.010461167432367802,
-0.002505559241399169,
0.015508863143622875,
-0.025726180523633957,
-0.029091311618685722,
0.007541062775999308,
-0.013289827853441238,
0.0029566818848252296,
0.009754002094268799
] | 2025-01-10 | 1 | 39791458 | [
"allogeneic hematopoietic stem cell transplantation",
"consolidation therapy",
"blinatumomab administration",
"T)-cell therapy",
"based measurable residual disease analysis",
"different toxicity profiles",
"CAR T-cell therapies",
"blinatumomab",
"conventional chemotherapy",
"Newer generation CAR T-cell products",
"MRD negative B",
"frontline adult B-cell acute lymphoblastic leukemia",
"next generation",
"chimeric antigen receptor",
"T",
"chemotherapy",
"immunotherapeutic agents",
"patients",
"HSCT",
"ongoing clinical trials",
"inotuzumab ozogamicin",
"treatment intensification",
"CAR",
"subcutaneous blinatumomab",
"ALL",
"CAR T-cells",
"positive outcomes",
"induction",
"questions",
"low-intensity chemotherapy"
] | [
"CAR T-cell therapy",
"Inotuzumab ozogamicin",
"NGS",
"blinatumomab",
"measurable residual disease"
] | 0 | 10.1080/10428194.2025.2449582 | [
"Senapati",
"Kantarjian",
"Habib",
"Haddad",
"Jain",
"Short",
"Jabbour"
] | [
"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."
] | [
"39791458"
] | [] | 6.47795 | 6.393093 |
39789380 | 51 | Adoptive cell therapies in thoracic malignancies: a comprehensive review. | This review aims to summarize recent studies and findings within adoptive cell therapies, including tumor-infiltrating lymphocytes, genetically engineered T cell receptors, and chimeric antigen receptor T cells, in the treatment of thoracic malignancies, including non-small cell lung cancer, small cell lung cancer, and malignant pleural mesothelioma. Several trials are ongoing, and a few have reported results, suggesting that adoptive cell therapies may represent a potential treatment option for these patients, especially when checkpoint inhibition has failed. We also discuss the potential implementation of these therapies, as they present a new toxicity profile and an intrinsic financial burden. Despite the challenges to overcome, such as the accurate identification of antigens and developing strategies to improve efficacy and toxicity profiles, new cellular therapies are experiencing significant development in the field of thoracic malignancies. | [
0.023807097226381302,
0.0025149944704025984,
0.05594440549612045,
0.038419101387262344,
-0.02322671376168728,
-0.00009841979044722393,
0.011362995952367783,
0.011960449628531933,
0.006037124898284674,
0.008654540404677391,
-0.015442749485373497,
-0.0332980714738369,
-0.025195466354489326,
0.03190970420837402,
0.012119770050048828,
-0.04265248775482178,
0.05576232448220253,
-0.04099099710583687,
0.03664381057024002,
0.04725003242492676,
0.03746317699551582,
0.02132624387741089,
0.01894780993461609,
0.002034186851233244,
-0.0769747644662857,
-0.011983209289610386,
0.008330208249390125,
-0.009906347841024399,
-0.026697633787989616,
-0.02697075717151165,
0.002864931710064411,
-0.019653374329209328,
-0.006532157771289349,
-0.005004384089261293,
-0.024216780439019203,
0.0305440966039896,
0.03746317699551582,
0.023852618411183357,
-0.018834009766578674,
-0.0006774695357307792,
0.055170558393001556,
0.014850986190140247,
0.00995186809450388,
0.09814168512821198,
-0.09777752310037613,
0.01498754695057869,
0.017013197764754295,
-0.05171101912856102,
-0.020017536357045174,
-0.02220250852406025,
-0.004782472737133503,
-0.009701506234705448,
-0.008131057024002075,
0.022191127762198448,
-0.03896534442901611,
0.028177043423056602,
-0.02156522497534752,
-0.008335898630321026,
-0.0056388224475085735,
-0.0006796033121645451,
-0.009331653825938702,
-0.020108576864004135,
0.035665128380060196,
-0.03377603739500046,
-0.06673270463943481,
-0.010771232657134533,
-0.05189310014247894,
-0.009650295600295067,
-0.009291823953390121,
-0.015340329147875309,
0.017582202330231667,
0.0036786063574254513,
0.006298866588622332,
-0.01047535054385662,
-0.012757053598761559,
0.005815213546156883,
0.029838532209396362,
0.0428345687687397,
0.0015391538618132472,
-0.03468644246459007,
0.022623570635914803,
0.014361643232405186,
0.0065435380674898624,
-0.01281395461410284,
-0.01958509348332882,
0.02403469942510128,
0.0009345879079774022,
0.01886815018951893,
-0.03006613440811634,
-0.010088428854942322,
-0.02322671376168728,
0.0066118184477090836,
-0.053895991295576096,
0.02348845638334751,
0.02269185148179531,
0.020688960328698158,
-0.012870854698121548,
-0.06045091152191162,
0.04552026465535164,
0.027152838185429573,
0.03363947570323944,
0.013906440697610378,
-0.0013599179219454527,
-0.008830931037664413,
0.02767631970345974,
-0.02617415226995945,
-0.005490881856530905,
-0.02189524658024311,
0.05243934318423271,
0.00836434867233038,
0.022794272750616074,
0.018503986299037933,
-0.015135487541556358,
0.045406464487314224,
-0.06923632323741913,
-0.03693969547748566,
-0.025582388043403625,
-0.013382957316935062,
-0.016364535316824913,
0.0642290934920311,
0.013951960951089859,
0.05740105360746384,
0.03903362527489662,
-0.00561037240549922,
0.021587984636425972,
-0.03591548651456833,
0.07733892649412155,
-0.044609859585762024,
-0.04711347445845604,
-0.03987574949860573,
0.044382255524396896,
0.02220250852406025,
0.034618161618709564,
-0.01832190528512001,
-0.066641665995121,
-0.003581875702366233,
-0.026765914633870125,
0.01792360469698906,
-0.02095070108771324,
-0.02403469942510128,
0.00439839530736208,
-0.01905023120343685,
0.0024168414529412985,
-0.0022134229075163603,
-0.027334919199347496,
-0.024239540100097656,
0.024854063987731934,
0.04633962735533714,
0.02348845638334751,
0.03641621023416519,
-0.0602688305079937,
0.07588227838277817,
0.015146867372095585,
0.02760804072022438,
-0.03673485293984413,
-0.007499463390558958,
0.014338882640004158,
0.05448775738477707,
-0.017001818865537643,
-0.06604990363121033,
-0.014942026697099209,
0.02997509390115738,
-0.005135254934430122,
0.002973042195662856,
0.007493773475289345,
-0.024717502295970917,
-0.011078494600951672,
0.037645258009433746,
-0.026788674294948578,
-0.0002869910385925323,
-0.00864885002374649,
-0.055716801434755325,
-0.048342518508434296,
-0.012165290303528309,
-0.019448531791567802,
-0.027175597846508026,
0.029610931873321533,
0.008933351375162601,
-0.0388743057847023,
-0.02339741587638855,
0.01498754695057869,
0.04590718448162079,
0.014998926781117916,
0.019164031371474266,
-0.026378992944955826,
-0.000048409732698928565,
-0.014623384922742844,
0.032251108437776566,
-0.049435004591941833,
-0.03466368094086647,
0.0021721699740737677,
-0.019403012469410896,
0.02562790922820568,
0.02166764624416828,
-0.006873559672385454,
0.0059005641378462315,
0.011482486501336098,
0.033275313675403595,
-0.019937874749302864,
-0.04292560741305351,
0.03894258663058281,
-0.006680098827928305,
-0.01911851018667221,
-0.0038293921388685703,
-0.02649279311299324,
-0.009212163276970387,
-0.00583228375762701,
0.04925292357802391,
0.007408422883599997,
-0.03848738223314285,
0.027107317000627518,
-0.0002519617846701294,
-0.002697075717151165,
0.021918006241321564,
-0.030589617788791656,
0.0036330861039459705,
-0.027653560042381287,
-0.000954503018874675,
0.060223307460546494,
0.017024578526616096,
0.01777566224336624,
0.011124014854431152,
0.018071545287966728,
0.02037031762301922,
-0.028768805786967278,
0.017070099711418152,
-0.008779720403254032,
-0.007516533602029085,
-0.013701599091291428,
-0.04934396594762802,
-0.005268970504403114,
-0.02888260781764984,
-0.014680285006761551,
-0.024558182805776596,
-0.041286878287792206,
-0.033662233501672745,
0.017309080809354782,
0.0046914322301745415,
0.011454036459326744,
-0.014498203992843628,
0.04085443541407585,
-0.0002160434378311038,
0.03782733902335167,
-0.019880974665284157,
-0.026606593281030655,
0.014498203992843628,
-0.003155123209580779,
-0.051437899470329285,
0.03227386623620987,
0.014998926781117916,
-0.017570821568369865,
0.050163332372903824,
0.00719789182767272,
-0.0028820016887038946,
0.019334731623530388,
-0.01768462173640728,
0.04035371541976929,
-0.016148313879966736,
-0.007385662756860256,
-0.0012646098621189594,
0.0022546756081283092,
0.01959647424519062,
-0.023761577904224396,
0.00299295736476779,
-0.06468429416418076,
-0.011653187684714794,
0.030976539477705956,
0.021360384300351143,
0.04003507271409035,
-0.004293129779398441,
0.010890723206102848,
0.027653560042381287,
0.06067851185798645,
-0.03709901496767998,
-0.0396481491625309,
-0.017548061907291412,
0.011505247093737125,
0.01793498359620571,
0.013906440697610378,
0.0285639651119709,
-0.015021687373518944,
0.022316308692097664,
0.019471293315291405,
-0.05275798588991165,
-0.03468644246459007,
0.00042177370050922036,
-0.0028023412451148033,
-0.012449792586266994,
-0.008199337869882584,
-0.008387108333408833,
-0.013109835796058178,
0.00400293804705143,
-0.03734937682747841,
-0.0037440417800098658,
0.014407163485884666,
0.02467198297381401,
-0.0063330065459012985,
-0.043972574174404144,
-0.011892168782651424,
0.049207404255867004,
-0.052621424198150635,
0.012859474867582321,
-0.03539200499653816,
-0.04217452555894852,
0.03860118240118027,
0.03029373474419117,
-0.029292289167642593,
0.030726177617907524,
0.03495956212282181,
0.058402497321367264,
0.010168088600039482,
0.017309080809354782,
0.010054288432002068,
0.014907886274158955,
0.0018008954357355833,
0.027744600549340248,
0.043904293328523636,
-0.016842497512698174,
-0.0075905038975179195,
-0.04447329789400101,
-0.014134041965007782,
-0.03377603739500046,
-0.011983209289610386,
0.019937874749302864,
0.013485378585755825,
-0.01578415185213089,
0.00140828313305974,
-0.017092859372496605,
0.05740105360746384,
-0.008580570109188557,
-0.012131149880588055,
-0.046589989215135574,
0.06172547861933708,
-0.03204626590013504,
0.021986287087202072,
-0.007664474193006754,
-0.0023912363685667515,
-0.02021099627017975,
0.03341187536716461,
0.04577062651515007,
-0.04053579643368721,
0.007522223517298698,
-0.037645258009433746,
0.042789049446582794,
0.012165290303528309,
-0.013041555881500244,
-0.01611417345702648,
0.027175597846508026,
-0.009280444122850895,
0.04256144538521767,
0.03275182843208313,
0.03862394392490387,
0.014361643232405186,
-0.021826965734362602,
-0.020575158298015594,
0.01594347320497036,
-0.02330637536942959,
-0.06300004571676254,
0.022578051313757896,
0.01862916722893715,
-0.01902746967971325,
-0.0022091553546488285,
-0.037554219365119934,
0.03839634358882904,
0.042789049446582794,
0.03434503823518753,
-0.04989020898938179,
0.04495126008987427,
-0.03386707603931427,
-0.025423066690564156,
-0.0043301149271428585,
0.019289212301373482,
0.009673056192696095,
0.0035761857870966196,
-0.02911020815372467,
0.058812182396650314,
0.020905181765556335,
-0.009183713234961033,
0.02626519277691841,
0.04110479727387428,
0.03507336229085922,
0.021462803706526756,
0.0015548014780506492,
-0.011994589120149612,
-0.019573712721467018,
0.02141728438436985,
-0.02164488472044468,
-0.04861564189195633,
-0.07397042959928513,
0.049617085605859756,
0.02236182987689972,
-0.009929107502102852,
-0.005894874222576618,
0.001091775018721819,
-0.02703903615474701,
0.05530712008476257,
-0.0658223032951355,
0.06318212300539017,
0.05908530205488205,
0.006776829250156879,
0.011254885233938694,
-0.022964973002672195,
-0.00640128692612052,
-0.02062067948281765,
-0.010640361346304417,
-0.019550953060388565,
-0.011317475698888302,
-0.017001818865537643,
0.0349140428006649,
-0.04820596054196358,
-0.02451266162097454,
-0.00044809008250012994,
0.03313875198364258,
0.015078587457537651,
0.006276106461882591,
-0.04392705485224724,
-0.034231238067150116,
0.05426015332341194,
-0.011050043627619743,
0.014543724246323109,
0.008620399981737137,
-0.05653616786003113,
0.042083483189344406,
-0.03022545576095581,
0.007755514699965715,
0.011095563881099224,
0.03395811840891838,
-0.037645258009433746,
-0.02640175260603428,
-0.056354086846113205,
-0.04966260865330696,
0.034549880772829056,
0.012483932077884674,
-0.029132969677448273,
-0.01919817179441452,
0.029793012887239456,
-0.01439578365534544,
0.03229662775993347,
-0.001699897344224155,
-0.014953406527638435,
-0.02626519277691841,
-0.005820903927087784,
0.0024424465373158455,
-0.01237013190984726,
0.0285639651119709,
0.017400121316313744,
0.006355766672641039,
0.034777481108903885,
-0.04156000167131424,
-0.023807097226381302,
0.024922344833612442,
-0.05512503907084465,
0.029474370181560516,
0.027266638353466988,
-0.03282010927796364,
-0.04256144538521767,
-0.007886385545134544,
-0.07356074452400208,
0.013382957316935062,
0.010850892402231693,
0.07711132615804672,
-0.012358751147985458,
0.002439601579681039,
-0.027152838185429573,
-0.02610587142407894,
0.02172454632818699,
0.08535049110651016,
-0.013929200358688831,
0.02514994516968727,
-0.05130133777856827,
0.04606650769710541,
-0.05535263940691948,
-0.04212900251150131,
-0.011653187684714794,
0.0038208570331335068,
0.02656107395887375,
0.02617415226995945,
-0.01831052638590336,
-0.04420017451047897,
-0.016990438103675842,
0.01815120503306389,
0.019232312217354774,
-0.0034879902377724648,
-0.03516440466046333,
0.032319385558366776,
0.01122643519192934,
-0.040239911526441574,
0.015294808894395828,
-0.017502540722489357,
0.016000373288989067,
0.004187864251434803,
0.01094193384051323,
0.00963322538882494,
-0.009291823953390121,
0.005459586624056101,
-0.01769600249826908,
-0.010862273164093494,
-0.013951960951089859,
-0.026697633787989616,
-0.0071068513207137585,
-0.014020240865647793,
0.03994403034448624,
0.02060929872095585,
0.031363461166620255,
0.07114817202091217,
0.025650668889284134,
0.02030203677713871,
0.06932736188173294,
0.010168088600039482,
0.01808292418718338,
-0.031295180320739746,
-0.020825520157814026,
0.03932950645685196,
-0.00983237661421299,
-0.03468644246459007,
-0.019880974665284157,
-0.04504230245947838,
0.000915384036488831,
0.007226341869682074,
-0.0049730888567864895,
0.02037031762301922,
0.00034140198840759695,
-0.01138006616383791,
-0.010697262361645699,
0.01603451371192932,
-0.02212284877896309,
-0.02649279311299324,
0.003613170934841037,
-0.008216407150030136,
-0.028268083930015564,
-0.012950515374541283,
-0.0285639651119709,
0.019368872046470642,
0.01463476475328207,
-0.019084369763731956,
0.00027525535551831126,
-0.017707383260130882,
0.016796978190541267,
-0.04258420690894127,
-0.016296254470944405,
-0.016125554218888283,
-0.007431183010339737,
0.029224010184407234,
-0.007744134869426489,
0.006094025447964668,
0.004990159068256617,
-0.0036786063574254513,
-0.01343985740095377,
-0.011289025656878948,
-0.009030082263052464,
0.038282543420791626,
-0.0364844910800457,
0.013906440697610378,
-0.007101160939782858,
0.012005969882011414,
-0.005126719828695059,
-0.02157660573720932,
-0.03498232364654541,
-0.0034510050900280476,
-0.014077141880989075,
-0.018515367060899734,
-0.026629354804754257,
-0.01023067906498909,
-0.011118324473500252,
0.0013656079536303878,
0.009166643023490906,
0.005530712194740772,
-0.003379879519343376,
-0.016387294977903366,
0.03878326341509819,
-0.005883493926376104,
-0.012506692670285702,
0.00398302311077714,
-0.02594655007123947,
0.026128631085157394,
-0.009098363108932972,
0.006327316630631685,
-0.011055734008550644,
-0.012495312839746475,
-0.006668718531727791,
-0.029610931873321533,
-0.03220558539032936,
-0.01664903573691845,
0.05289454758167267,
0.02546858787536621,
0.025673428550362587,
-0.025514107197523117,
-0.014498203992843628,
-0.003843617159873247,
0.014213702641427517,
0.06432013213634491,
0.022179748862981796,
0.028063243255019188,
-0.008574879728257656,
-0.01118091493844986,
0.04495126008987427,
-0.0073913526721298695,
-0.04515610262751579,
-0.021826965734362602,
-0.014111281372606754,
-0.00959339551627636,
-0.0009352991473861039,
-0.004785317927598953,
-0.04552026465535164,
-0.022555289790034294,
0.03432228043675423,
0.009360103867948055,
-0.040808916091918945,
0.041833121329545975,
-0.01625073328614235,
0.03935226798057556,
0.043175969272851944,
-0.04734107479453087,
-0.00860332977026701,
0.02362501621246338,
-0.007664474193006754,
0.0018805558793246746,
0.00955356564372778,
0.02608311176300049,
0.005647357553243637,
-0.02854120545089245,
-0.011584906838834286,
0.007607574108988047,
0.021690405905246735,
-0.009701506234705448,
-0.04335805028676987,
-0.040490273386240005,
-0.0018805558793246746,
0.03734937682747841,
0.013280536979436874,
-0.007954666391015053,
-0.00129875005222857,
0.000011046665349567775,
0.03910190612077713,
0.005323025863617659,
-0.03971643000841141,
0.05334974825382233,
-0.013712979853153229,
0.0024580941535532475,
0.031204141676425934,
-0.017479781061410904,
-0.0023201110307127237,
-0.01759358122944832,
-0.005061284173280001,
0.00041181614506058395,
0.018936429172754288,
-0.00260888016782701,
-0.01435026340186596,
0.014225082471966743,
-0.009360103867948055,
-0.008728510700166225,
-0.024922344833612442,
0.02870052680373192,
0.018811248242855072,
-0.007049950771033764,
0.015328948386013508,
0.015169627964496613,
-0.017172519117593765,
0.02530926652252674,
0.06600438058376312,
-0.013155356049537659,
-0.015454129315912724,
0.009946177713572979,
0.012165290303528309,
-0.02076862007379532,
0.015237907879054546,
0.010401380248367786,
-0.007840865291655064,
0.003749731695279479,
-0.029838532209396362,
0.054851919412612915,
0.003812322160229087,
0.013371577486395836,
-0.02428506128489971,
0.0019488362595438957,
0.01340571790933609,
-0.019869595766067505,
-0.0021821276750415564,
-0.02007443644106388,
0.025263747200369835,
-0.000019926228560507298,
0.023898137733340263,
-0.04158275946974754,
-0.037235576659440994,
-0.0033884146250784397,
-0.014725805260241032,
0.00896180234849453,
0.0008321673376485705,
0.019619233906269073,
-0.00561037240549922,
0.013235016725957394,
-0.028609486296772957,
-0.023272234946489334,
-0.009667365811765194,
0.0013862343039363623,
0.02458094246685505,
0.008620399981737137,
-0.03821426257491112,
-0.007442563306540251,
-0.03766801953315735,
0.03989851102232933,
0.04076339676976204,
0.045338183641433716,
-0.038350820541381836,
0.020814141258597374,
-0.009929107502102852,
0.0018848234321922064,
-0.01824224554002285,
-0.002941746963188052,
-0.008927661925554276,
-0.024489901959896088,
-0.006315936800092459,
-0.007442563306540251,
-0.027380438521504402,
-0.02111002244055271,
-0.004042768385261297,
-0.009758406318724155,
0.006708548869937658,
-0.01237013190984726,
0.013496758416295052,
0.011129704304039478,
-0.002058369340375066,
0.010071358643472195,
0.011306095868349075,
0.04076339676976204,
0.038510143756866455,
-0.032865628600120544,
0.04852459952235222,
-0.018105685710906982,
0.009371484629809856,
-0.010720022022724152,
-0.006589058320969343,
-0.01934611238539219,
-0.029952334240078926,
-0.026515552774071693,
0.001369164208881557,
-0.017582202330231667,
-0.03623412922024727,
0.019380252808332443,
0.021075882017612457,
0.0018862459110096097,
-0.05544368177652359,
-0.0452243834733963,
-0.00739704305306077,
0.007152371574193239,
0.035574086010456085,
0.021383143961429596,
0.01801464520394802,
0.010532250627875328,
-0.021314863115549088,
0.00009619711636332795,
0.007049950771033764,
-0.01942577213048935,
-0.021371763199567795,
0.006520777940750122,
-0.034140199422836304,
0.007038570940494537,
-0.014486824162304401,
-0.014555104076862335,
-0.025423066690564156,
-0.011135394684970379,
0.00539130624383688,
0.00027187689556740224,
-0.006116785574704409,
-0.007345832418650389,
0.015556550584733486,
-0.007937596179544926,
0.0068963197991251945,
-0.0009288978762924671,
0.01383815985172987,
-0.028928127139806747,
-0.02070033922791481,
0.02371605671942234,
-0.040968235582113266,
-0.0037155915051698685,
0.0020725945942103863,
-0.007647404447197914,
0.016762837767601013,
-0.005968844518065453,
0.019528193399310112,
-0.003837927244603634,
-0.0016814047703519464,
0.0008442586404271424,
0.003505060216411948,
-0.018754348158836365,
-0.015021687373518944,
-0.011289025656878948,
0.01848122663795948,
-0.01856088824570179,
-0.005158015061169863,
-0.022964973002672195,
0.06645958870649338,
-0.019733034074306488,
0.02412573993206024,
-0.02990681305527687,
0.012734293937683105,
0.020085817202925682,
-0.07283242046833038,
-0.01642143540084362,
-0.008654540404677391,
0.01815120503306389,
-0.01999477669596672,
0.0032945291604846716,
-0.05885770171880722,
0.015670351684093475,
-0.0036160158924758434,
-0.027334919199347496,
0.00781241524964571,
-0.030521336942911148,
0.03147726133465767,
-0.01221081055700779,
-0.007903455756604671,
0.006059885025024414,
-0.020825520157814026,
-0.03896534442901611,
0.00600867485627532,
0.020097196102142334,
-0.022817032411694527,
0.02330637536942959,
-0.000170167550095357,
0.046430669724941254,
-0.018606407567858696,
0.023374656215310097,
-0.018515367060899734,
-0.011914929375052452,
-0.027175597846508026,
-0.014976167120039463,
-0.03618860989809036,
0.01840156689286232,
-0.008620399981737137,
0.0024580941535532475,
0.004773937631398439,
-0.02364777773618698,
0.01688801869750023,
-0.017081478610634804,
-0.01854950748383999,
-0.0037269715685397387,
-0.026287952437996864,
0.026765914633870125,
0.030817218124866486,
0.023067394271492958,
0.0035192854702472687,
-0.026151390746235847,
-0.01951681263744831,
0.02378433756530285,
0.024148499593138695,
-0.024558182805776596,
0.04504230245947838,
-0.0555347204208374,
-0.02364777773618698,
0.004085443448275328,
0.005158015061169863,
-0.024376101791858673,
0.016944918781518936,
0.025673428550362587,
0.01775290258228779,
-0.005163704976439476,
-0.02767631970345974,
0.04008059203624725,
0.024489901959896088,
0.00036042803549207747,
-0.03179590404033661,
-0.02293083257973194,
-0.000410749256843701,
0.030635137110948563,
-0.0024381792172789574,
0.014031621627509594,
0.00045129074715077877,
0.008341588079929352,
-0.04313044995069504,
0.01296189520508051,
-0.021474184468388557,
-0.02863224595785141,
0.008540739305317402,
-0.02378433756530285,
0.006856489926576614,
0.014384402893483639,
-0.014759945683181286,
0.007675854489207268,
0.03960262984037399,
-0.0026984980795532465,
-0.011493866331875324,
0.008096916601061821,
-0.018276385962963104,
0.017024578526616096,
0.02015409618616104,
-0.009325964376330376,
0.008529359474778175,
-0.004864978138357401,
0.014623384922742844,
0.00033926821197383106,
-0.0023485610727220774,
0.012461172416806221,
-0.018276385962963104,
-0.020518258213996887,
0.024763023480772972,
0.0009829532355070114,
0.026196911931037903,
-0.021849727258086205,
-0.016080033034086227,
0.000962326826993376,
-0.00062483677174896,
0.011499556712806225,
0.010537941008806229,
-0.014145421795547009,
-0.0034453149419277906,
-0.001517816330306232,
0.02854120545089245,
-0.024945104494690895,
0.035414766520261765,
-0.0015946316998451948,
0.019721655175089836,
0.0006262592505663633,
0.02822256274521351,
-0.007584813982248306,
0.013337437063455582,
-0.010122568346560001,
0.06076955050230026,
0.01696767844259739,
-0.012916374951601028,
0.0024765869602560997,
-0.005257590673863888,
-0.0012226458638906479,
-0.0005266836960799992,
-0.041286878287792206,
0.008273308165371418,
0.0022447179071605206,
0.05020885169506073,
0.006111095193773508,
0.03243318945169449,
0.0026017676573246717,
0.004523576237261295,
0.05353182926774025,
0.014816845767199993,
0.02576446905732155,
0.005934704560786486,
0.02951989136636257,
0.02348845638334751,
-0.010839512571692467,
-0.024467142298817635,
-0.028450164943933487,
0.040649596601724625,
-0.014964786358177662,
-0.0373038575053215,
0.001527773798443377,
-0.009820996783673763,
-0.00904146209359169,
0.037144534289836884,
0.018196726217865944,
0.03641621023416519,
0.05781073495745659,
0.00019897334277629852,
0.0420152023434639,
0.026697633787989616,
0.024967864155769348,
-0.04488297924399376,
0.012461172416806221,
-0.03744041547179222,
0.05339526757597923,
-0.03345739468932152,
-0.02870052680373192,
-0.025423066690564156,
-0.03816873952746391,
-0.03361671417951584,
0.004887738265097141,
0.019858215004205704,
-0.00033997948048636317,
-0.00963322538882494,
-0.030157174915075302,
0.032729070633649826,
0.02348845638334751,
-0.022225268185138702,
0.00499869417399168,
0.02703903615474701,
0.029292289167642593,
0.0021095797419548035,
0.014919266104698181,
-0.037872858345508575,
0.011869409121572971,
0.011442656628787518,
0.03368499502539635,
0.050891656428575516,
-0.04222004488110542,
-0.009718576446175575,
-0.017240799963474274,
-0.004022853448987007,
-0.005533556919544935,
0.0011550766648724675,
-0.026424512267112732,
0.01864054799079895,
0.041764840483665466,
0.018526747822761536,
-0.05002677068114281,
-0.015021687373518944,
0.0073060025461018085,
-0.014464063569903374,
-0.02355673722922802,
-0.044609859585762024,
0.023533975705504417,
0.07560915499925613,
0.013473997823894024,
-0.03575616702437401,
0.006964600179344416,
0.005579077173024416,
-0.018925050273537636,
-0.01642143540084362,
0.01562483049929142,
0.013303296640515327,
0.0658223032951355,
-0.0332980714738369,
0.028290843591094017,
0.005601837299764156,
0.00249934708699584,
-0.03134070336818695,
-0.005741243250668049,
-0.024967864155769348,
0.01444130390882492,
-0.05070957541465759,
-0.04165104031562805,
-0.01482822559773922,
-0.01300741545855999,
0.0037724918220192194,
0.034618161618709564,
0.05171101912856102,
0.020484117791056633,
-0.002832213882356882,
0.0023542512208223343,
-0.005061284173280001,
0.04244764521718025,
0.0036757613997906446,
0.008899211883544922,
0.004236229695379734,
0.023203954100608826,
-0.011340235359966755,
-0.018185345456004143,
0.03912466764450073,
-0.01423646230250597,
0.08475872874259949,
0.021189682185649872,
-0.01664903573691845,
-0.026788674294948578,
-0.007152371574193239,
0.008830931037664413,
0.05535263940691948,
-0.0044609857723116875,
-0.0372810959815979,
-0.016842497512698174,
-0.015146867372095585,
0.01300741545855999,
0.009126813150942326,
0.015078587457537651,
0.04570234566926956,
0.02095070108771324,
0.011846648529171944,
-0.009673056192696095,
0.02339741587638855,
-0.0003117071173619479,
-0.005277505610138178,
-0.021053122356534004,
-0.0010946200927719474,
-0.008626090362668037,
0.01237013190984726,
0.00682234950363636,
0.005226295441389084,
-0.03903362527489662,
0.017024578526616096,
0.008119677193462849,
-0.016000373288989067,
-0.0048735132440924644,
-0.011766987852752209,
-0.013485378585755825,
-0.0011045776773244143,
-0.018856769427657127,
0.028655005618929863,
-0.017821183428168297,
-0.0014075719518586993,
0.008193647488951683,
0.0068280394189059734,
-0.02015409618616104,
0.002685695653781295,
0.004830838181078434,
0.012381511740386486,
0.008176577277481556,
-0.01343985740095377,
-0.01903885044157505,
0.021849727258086205,
-0.012586353346705437,
-0.034231238067150116,
-0.009377174079418182,
-0.021747305989265442,
-0.02838188409805298,
-0.010924863629043102,
-0.03377603739500046,
-0.01444130390882492,
0.011732848361134529,
-0.0073060025461018085,
-0.0006010097567923367,
0.015795530751347542,
0.04472365975379944,
0.006025745067745447,
0.0015789842000231147,
-0.002967352280393243,
0.012916374951601028,
-0.022714611142873764,
-0.015306188724935055,
0.011835268698632717,
-0.018287766724824905,
-0.06236276030540466,
0.018595026805996895,
0.025832749903202057,
0.004919033497571945,
0.0015306188724935055,
-0.0062021357007324696,
-0.01816258579492569,
-0.00005045458965469152,
0.018993329256772995,
0.01463476475328207,
-0.016444195061922073,
-0.00009797525854082778,
-0.01054363138973713,
-0.00563313253223896,
-0.04545198380947113,
0.029701972380280495,
0.012028729543089867,
-0.006156615447252989,
-0.010355859994888306,
-0.018447086215019226,
0.01181250810623169,
-0.005166549701243639,
0.010509490966796875,
-0.024171259254217148,
0.022976353764533997,
0.009769786149263382,
0.013473997823894024,
0.0033201342448592186,
0.017479781061410904,
-0.030498577281832695,
-0.003468075068667531,
-0.00541406637057662,
-0.01966475322842598,
0.018754348158836365,
0.011528006754815578,
0.011892168782651424,
-0.021132782101631165,
-0.012779814191162586,
-0.00880248099565506,
-0.011044354178011417,
0.05526160076260567,
-0.0022774357348680496,
-0.03536924347281456,
0.03357119485735893,
0.0467948317527771,
-0.003812322160229087,
-0.012722914107143879,
-0.013394337147474289,
-0.006190755870193243,
0.02172454632818699,
-0.013417097739875317,
0.04934396594762802,
0.045406464487314224,
-0.02269185148179531,
-0.0008471036562696099,
-0.0038293921388685703,
0.0075734336860477924,
0.004253299441188574,
0.0001424286310793832,
-0.0007389930542558432,
-0.02505890466272831,
0.03746317699551582,
-0.009308894164860249,
0.006076955236494541,
-0.000042608568037394434,
0.03077169880270958,
0.026629354804754257,
0.025559628382325172,
-0.005860733799636364,
0.02394365891814232,
0.005419756285846233,
-0.014247842133045197,
-0.013929200358688831,
-0.01435026340186596,
-0.021622125059366226,
-0.02904192917048931,
-0.029997853562235832,
-0.00879679061472416,
0.010759851895272732,
0.011158154346048832,
0.022953592240810394,
0.006190755870193243,
0.030088894069194794,
0.009758406318724155,
-0.04105927795171738,
0.01383815985172987,
0.0054567414335906506,
0.021929387003183365,
0.00033197784796357155,
0.016546616330742836,
-0.043267011642456055,
-0.011630427092313766,
0.011721467599272728,
-0.013371577486395836,
0.0064468071796,
0.0038265471812337637,
-0.015670351684093475,
0.041036516427993774,
-0.003044167533516884,
0.014907886274158955,
-0.013621939346194267,
-0.00717513170093298,
-0.042880088090896606,
0.025104425847530365,
0.016637656837701797,
-0.017809802666306496,
0.04474641755223274,
0.001410416909493506,
-0.04344909265637398,
-0.014543724246323109,
-0.018287766724824905,
-0.014145421795547009,
0.0033485842868685722,
0.012711533345282078,
-0.0010476773604750633,
0.007829485461115837,
0.021474184468388557,
0.01483960635960102,
0.00825054757297039,
-0.005579077173024416,
0.014577864669263363,
0.003473765216767788,
0.0020996222738176584,
0.020006155595183372,
-0.04545198380947113,
0.00561321759596467,
-0.001867753337137401,
-0.021997667849063873,
-0.02253253012895584,
0.010446900501847267,
-0.0038094769697636366,
0.009451144374907017,
0.03536924347281456,
0.010970383882522583,
0.021075882017612457,
-0.02412573993206024,
-0.04256144538521767,
-0.008324517868459225,
0.02617415226995945,
0.021189682185649872,
0.00014811867731623352,
0.003086842829361558,
0.017787043005228043,
0.006736998911947012,
-0.0019630612805485725,
-0.0026842730585485697,
-0.020506879314780235,
-0.004549181554466486,
0.01276843436062336,
0.006526467856019735,
-0.03498232364654541,
-0.026447273790836334,
-0.0007951821316964924,
-0.022145608440041542,
0.01927783153951168,
0.01865192875266075,
-0.013701599091291428,
-0.0019232311751693487,
-0.02236182987689972,
0.011721467599272728,
-0.0006433293456211686,
-0.007510843686759472,
0.005402686074376106,
-0.011949068866670132,
-0.001034874701872468,
-0.025423066690564156,
0.03734937682747841,
0.007516533602029085,
-0.01054363138973713,
-0.015408609062433243,
-0.016865257173776627,
0.009894967079162598,
-0.00796604622155428,
0.0002110646601067856,
-0.0046914322301745415,
0.0152720483019948,
-0.007886385545134544,
-0.025013385340571404,
0.047932837158441544,
-0.014111281372606754,
0.010947623290121555,
-0.006526467856019735,
-0.015306188724935055,
-0.0038151671178638935,
-0.02299911342561245,
-0.0017553751822561026,
-0.005092579405754805,
-0.02245287038385868,
-0.0011060001561418176,
0.0002647643559612334,
-0.0061338553205132484,
0.016375914216041565,
-0.005783918313682079,
-0.03773630037903786,
0.0009523692424409091,
-0.001726925023831427,
-0.0333435945212841,
-0.10005354136228561,
-0.010611911304295063,
-0.0023855462204664946,
-0.023602256551384926,
0.016375914216041565,
-0.008091227151453495,
0.02965645119547844,
0.04012611135840416,
0.0031693484634160995,
-0.006674408446997404,
0.057628653943538666,
0.016296254470944405,
-0.012074249796569347,
0.007687234319746494,
0.004745487589389086,
0.015328948386013508,
-0.02942885085940361,
-0.013087076134979725,
-0.02030203677713871,
-0.005997294560074806,
0.028973648324608803,
-0.020586539059877396,
0.021053122356534004,
0.028427405282855034,
-0.004788162652403116,
0.0332980714738369,
-0.01903885044157505,
-0.0460209883749485,
-0.004130963701754808,
-0.014099901542067528,
-0.02949713170528412,
-0.006344386842101812,
0.006054195109754801,
-0.0013428478268906474,
0.012631873600184917,
-0.016045892611145973,
0.0008129634661599994,
0.011169535107910633,
-0.00396310817450285,
0.009667365811765194,
-0.01375850010663271,
-0.02872328646481037,
0.0012318921508267522,
0.01074278261512518,
-0.019949255511164665,
0.004648756701499224,
-0.022225268185138702,
-0.014691664837300777,
0.01296189520508051,
-0.010600531473755836,
0.026470033451914787,
-0.0341174378991127,
0.03782733902335167,
0.007129611447453499,
-0.024922344833612442,
0.018697448074817657,
0.021826965734362602,
0.03384431451559067,
0.0019374561961740255,
-0.012597733177244663,
-0.0015903642633929849,
-0.015841051936149597,
0.011710087768733501,
-0.012859474867582321,
-0.011903548613190651,
-0.008876451291143894,
-0.012825334444642067,
0.0024125739000737667,
0.004344339948147535,
-0.04274352639913559,
-0.0018122754991054535,
-0.028677765280008316,
-0.021053122356534004,
0.001961638918146491,
-0.007892075926065445,
-0.02149694412946701,
0.019562333822250366,
-0.038419101387262344,
-0.01911851018667221,
0.019084369763731956,
-0.002325800945982337,
-0.0009402779396623373,
-0.013815400190651417,
-0.027903921902179718,
-0.008244858123362064,
0.012836714275181293,
0.025445828214287758,
-0.009138192981481552,
0.011061424389481544,
0.004762557800859213,
-0.0009239190840162337,
-0.020586539059877396,
-0.005883493926376104,
0.022669091820716858,
0.02467198297381401,
-0.009291823953390121,
-0.039534348994493484,
0.015670351684093475,
-0.004964553751051426,
-0.019448531791567802,
-0.011084184050559998,
-0.0032632339280098677,
-0.005240520462393761,
-0.010998833924531937,
-0.001374854240566492,
0.014134041965007782,
0.03996679186820984,
0.010179469361901283,
0.02505890466272831,
-0.04333529248833656,
0.0058664241805672646,
-0.0016515320166945457,
0.00737428292632103,
0.0037411965895444155,
0.020188236609101295,
-0.03102205879986286,
-0.007653094362467527,
-0.018367426469922066,
0.0063330065459012985,
-0.043494611978530884,
-0.0043301149271428585,
0.022100087255239487,
-0.004825147800147533,
-0.03671209141612053,
0.02403469942510128,
0.006702858954668045,
-0.022782891988754272,
-0.0340946763753891,
-0.01439578365534544,
-0.019255071878433228,
-0.00797173660248518,
-0.02706179767847061,
0.02237320877611637,
-0.0034396250266581774,
0.02751700021326542,
-0.033821556717157364,
-0.007300312165170908,
-0.02917848899960518,
0.015886571258306503,
-0.009018702432513237,
-0.015169627964496613,
-0.01181250810623169,
-0.006236276123672724,
-0.02428506128489971,
-0.020415838807821274,
0.019334731623530388,
0.010930553078651428,
0.027744600549340248,
0.019550953060388565,
-0.015442749485373497,
-0.006902010180056095,
-0.06204411759972572,
-0.010697262361645699,
-0.010611911304295063,
-0.010731401853263378,
-0.012996035628020763,
0.013462617993354797,
0.003681451315060258,
-0.03388983756303787,
0.024171259254217148,
0.003869222477078438,
-0.02419402077794075,
0.007129611447453499,
-0.01106711383908987,
0.018583647906780243,
-0.029155729338526726,
-0.01602313295006752,
0.11207088828086853,
-0.02387537807226181,
-0.003485145280137658,
0.015192387625575066,
-0.017798423767089844,
0.014202321879565716,
0.02713007666170597,
-0.008415558375418186,
0.020188236609101295,
0.0003051280218642205,
0.0047426423989236355,
-0.01237013190984726,
0.04060407355427742,
0.0297474917024374,
0.006884939968585968,
-0.01225633081048727,
0.037645258009433746,
0.046134788542985916,
0.006537847686558962,
-0.008580570109188557,
0.01162473764270544,
0.016000373288989067,
-0.010509490966796875,
0.00979823712259531,
-0.022111468017101288,
0.004258989822119474,
-0.011078494600951672,
-0.005086889490485191,
0.0018634857842698693,
-0.017502540722489357,
-0.012005969882011414,
0.017969124019145966,
0.0380777008831501,
-0.02410298027098179,
0.0031408981885761023,
-0.02792668156325817,
0.005055594258010387,
-0.014907886274158955,
0.02624243125319481,
0.012734293937683105,
-0.0010697261895984411,
0.010014457628130913,
-0.02258943021297455,
0.023738818243145943,
0.010441210120916367,
0.04331253096461296,
-0.026947995647788048,
0.0023741661570966244,
-0.0036586911883205175,
-0.004779627546668053,
-0.009496664628386497,
-0.009360103867948055,
0.014976167120039463,
-0.01998339593410492,
-0.03639345243573189,
-0.017434261739253998,
0.006378526799380779,
0.019448531791567802,
0.0034623851533979177,
-0.03575616702437401,
-0.009166643023490906,
-0.0008848001016303897,
0.0028179888613522053,
-0.022145608440041542,
-0.013530898839235306
] | 2025-01-10 | 96 | 39789380 | [
"adoptive cell therapies",
"chimeric antigen receptor T cells",
"small cell lung cancer",
"non-small cell lung cancer",
"new cellular therapies",
"thoracic malignancies",
"recent studies",
"genetically engineered T cell receptors",
"developing strategies",
"malignant pleural mesothelioma",
"significant development",
"antigens",
"checkpoint inhibition",
"Several trials",
"a new toxicity profile",
"efficacy and toxicity profiles",
"a potential treatment option",
"results",
"findings",
"tumor-infiltrating lymphocytes",
"these therapies",
"an intrinsic financial burden",
"the accurate identification",
"the potential implementation",
"the treatment",
"these patients",
"the field",
"the challenges",
"This review",
"We"
] | [
"Adoptive cell therapies",
"CAR-T",
"MPM",
"NSCLC",
"SCLC",
"TCR",
"Tumor-infiltrating lymphocytes (TILs)"
] | 0 | 10.1007/s12094-024-03834-5
10.3322/caac.21660
10.6004/jnccn.2022.0025
10.1200/JCO.22.01990
10.1200/JCO.22.01989
10.1007/s12094-023-03216-3
10.1056/NEJMoa1809064
10.1200/JCO.20.00793
10.1016/S0140-6736(19)32222-6
10.1016/j.annonc.2021.02.025
10.1016/j.annonc.2022.01.074
10.1007/s00428-021-03031-7
10.1158/2159-8290.CD-12-0548
10.2147/OTT.S341179
10.1002/acg2.84
10.4049/jimmunol.168.9.4272
10.3390/cancers15143733
10.1002/JLB.5MA0122-467R
10.3389/fonc.2019.01519
10.1007/s00262-020-02735-0
10.3390/cancers15102855
10.1007/s00432-021-03613-7
10.1111/resp.14541
10.3892/mco.2022.2594
10.1093/jjco/hyp181
10.1016/j.cellimm.2023.104760
10.1158/1078-0432.CCR-19-4051
10.3389/fonc.2023.1124039/full
10.1038/s41389-020-00257-z
10.1038/cr.2017.90
10.1186/s13045-020-01024-8
10.1158/2159-8290.CD-21-0407
10.1158/1538-7445.AM2018-CT131
10.1016/j.ccell.2020.11.005
10.1158/0008-5472.CAN-13-2775
10.3389/fimmu.2021.665970/full
10.1007/s00018-009-8668-7
10.1038/nature22323
10.1016/j.lungcan.2017.11.018
10.1200/JCO.2019.37.15_suppl.TPS8576
10.1186/s13045-023-01464-y
10.1158/0008-5472.CAN-13-1541
10.1016/j.canlet.2022.215697
10.3389/fonc.2018.00513
10.1186/s13045-017-0548-2
10.1136/jitc-2021-003897
10.1016/j.omto.2021.02.004
10.1158/1538-7445.AM2023-3196
10.1097/00000478-200311000-00003
10.1158/2159-8290.CD-15-0583
10.1016/j.ymthe.2019.07.015
10.1186/1471-2407-12-615
10.1016/j.annonc.2020.10.474
10.1016/j.lungcan.2021.05.004
10.1016/j.canlet.2017.02.015
10.1186/2051-1426-2-25
10.1158/1078-0432.CCR-22-2428
10.1056/NEJMoa2210233
10.1016/j.jtho.2018.05.030
10.1126/sciimmunol.abd5778
10.1097/CJI.0000000000000495
10.1038/s41586-018-0130-2
10.1007/BF00199837
10.1038/s41591-021-01462-y
10.1158/2159-8290.CD-23-1334
10.3390/ijms19041041
10.1038/nri2887
10.1126/science.1260419
10.4049/jimmunol.1700236
10.1126/scisignal.abe2606
10.1007/s12026-012-8295-5
10.1136/jitc-2021-003581
10.1007/s00408-009-9181-3
10.1056/NEJMoa2119662
10.1158/2326-6066.CIR-22-0444
10.3390/curroncol28030179
10.1007/s12094-013-1146-6
10.1182/blood.2020010543
10.1016/j.blre.2018.11.002
10.1126/scitranslmed.abe7378
10.1126/scitranslmed.3006597
10.1016/j.molimm.2003.11.005
10.1002/cac2.12074
10.1158/2326-6066.CIR-21-0095
10.1186/1479-5876-10-169
10.1016/j.omto.2022.01.004
10.1016/j.annonc.2022.07.1009
10.1136/jitc-2021-002723
10.1126/sciadv.adf3700
10.1007/s11912-023-01443-z
10.1007/s11912-023-01465-7
10.1158/1078-0432.CCR-22-2293
10.1016/j.jval.2019.03.012
10.1200/JCO.19.01558
10.1371/journal.pone.0278950
10.1186/s12913-023-10443-5
10.1158/2643-3230.BCD-21-0084
10.1136/jitc-2023-008372
10.1186/s12885-018-4788-5
10.1038/d41586-024-00673-w | [
"Garitaonaindia",
"Martínez-Cutillas",
"Uribarren",
"Redondo",
"Calvo",
"Serna-Blasco",
"Provencio"
] | [
"Medical Oncology Department, Puerta de Hierro University Hospital, C/ Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain. [email protected].",
"Medical Oncology Department, Puerta de Hierro University Hospital, C/ Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain.",
"Medical Oncology Department, Puerta de Hierro University Hospital, C/ Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain.",
"Medical Oncology Department, Puerta de Hierro University Hospital, C/ Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain.",
"Medical Oncology Department, Puerta de Hierro University Hospital, C/ Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain.",
"Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Puerta De Hierro University Hospital, Majadahonda, Madrid, Spain.",
"Medical Oncology Department, Puerta de Hierro University Hospital, C/ Manuel de Falla, 1, 28222, Majadahonda, Madrid, Spain. [email protected]."
] | [
"39789380",
"33538338",
"35545176",
"36735893",
"36809080",
"37418123",
"30280641",
"32468956",
"31590988",
"33737119",
"35124183",
"33475835",
"23550147",
"37425981",
"11970966",
"37509394",
"35088475",
"32039010",
"33025047",
"37345192",
"34032893",
"37376985",
"36479256",
"20085909",
"37660477",
"33046521",
"36923424",
"32792499",
"28685773",
"33514401",
"34266984",
"33357452",
"24654231",
"34475869",
"19165418",
"28489825",
"29290251",
"30496013",
"37355629",
"24436149",
"35487310",
"30483473",
"29298689",
"35022195",
"14576474",
"26503962",
"31420241",
"23259649",
"33098996",
"33972125",
"28223167",
"25197555",
"37058256",
"36477031",
"29885479",
"33514641",
"37991241",
"29769722",
"3493073",
"34385708",
"38563600",
"29601534",
"21127503",
"25613900",
"29288199",
"34429382",
"22434516",
"35086946",
"19795170",
"30546433",
"35648703",
"37172100",
"34065612",
"24323466",
"34166502",
"30528964",
"33910979",
"24337479",
"15036911",
"34193461",
"22909342",
"35141398",
"34301811",
"36791198",
"37646900",
"37870696",
"36692420",
"31198183",
"31804859",
"36490296",
"38254079",
"35672571",
"34568831",
"38531663",
"30219040",
"39501120"
] | [] | 10.338913 | 4.398136 |
39786986 | 52 | The bidirectional interplay between T cell-based immunotherapies and the tumor microenvironment. | T cell-based therapies, including Tumor Infiltrating Lymphocyte Therapy (TIL), T cell receptor engineered T cells (TCR T), and Chimeric Antigen Receptor T cells (CAR T), are powerful therapeutic approaches for cancer treatment. While these therapies are primarily known for their direct cytotoxic effects on cancer cells, accumulating evidence indicates that they also influence the tumor microenvironment (TME), by altering the cytokine milieu and recruiting additional effector populations to help orchestrate the antitumor immune response. Conversely, the TME itself can modulate the behaviour of these therapies within the host by either supporting or inhibiting their activity. In this review we provide an overview of clinical and preclinical data on the bidirectional influences between T cell therapies and the TME. Unravelling the interactions between T cell-based therapies and the TME is critical for a better understanding of their mechanisms of action, resistance, and toxicity, with the goal of optimizing efficacy and safety. | [
0.003042378230020404,
0.004777819383889437,
0.043386027216911316,
0.02836696431040764,
-0.027702782303094864,
0.006866776384413242,
0.04077215492725372,
0.015136903151869774,
-0.044393014162778854,
0.029716750606894493,
-0.006925695575773716,
-0.006379352882504463,
-0.01945408061146736,
-0.013937092386186123,
0.01934695430099964,
-0.04400736093521118,
0.04032222554087639,
-0.00353247974999249,
0.038393955677747726,
0.0563054233789444,
0.02326776646077633,
0.019764745607972145,
-0.011741009540855885,
0.009239616803824902,
-0.03076658584177494,
0.0024545243941247463,
-0.01913270354270935,
0.031109388917684555,
-0.0189934391528368,
-0.02000042423605919,
0.026524396613240242,
-0.01405493076890707,
-0.05116337537765503,
-0.019271966069936752,
-0.022453607991337776,
0.0007559077930636704,
0.03526587784290314,
-0.0033182278275489807,
0.014494147151708603,
-0.0016765218460932374,
0.015576119534671307,
0.06474695354700089,
-0.009684190154075623,
0.09889871627092361,
-0.07524529844522476,
-0.04953506216406822,
0.006861419882625341,
-0.03670136630535126,
0.02193940430879593,
0.005187576171010733,
0.017793627455830574,
-0.015768947079777718,
-0.018264982849359512,
0.03522302582859993,
-0.050349216908216476,
0.02624586969614029,
-0.05043491721153259,
0.027488531544804573,
-0.0062454454600811005,
0.025945916771888733,
-0.026288719847798347,
-0.0033048370387405157,
0.010830437764525414,
0.0036449620965868235,
-0.06843208521604538,
-0.030316656455397606,
-0.011655308306217194,
-0.027659932151436806,
-0.01708659715950489,
0.011976686306297779,
0.022410757839679718,
-0.03571580722928047,
-0.010369796305894852,
0.006116894539445639,
0.029931003227829933,
-0.030830862000584602,
0.0037012032698839903,
0.0268243495374918,
0.011033977381885052,
-0.04979216307401657,
0.06239017844200134,
-0.01412991899996996,
0.02825983799993992,
0.007536313962191343,
-0.025174608454108238,
-0.0011911072069779038,
0.002671454567462206,
0.009078928269445896,
-0.065346859395504,
0.007466681767255068,
-0.013872816227376461,
-0.005150082055479288,
-0.02678149938583374,
0.05000641569495201,
0.008907526731491089,
0.01895058900117874,
-0.014333458617329597,
-0.08612930029630661,
0.01267300546169281,
0.054805658757686615,
0.05707672983407974,
-0.0025603112298995256,
-0.04132920876145363,
0.006175813730806112,
0.04025794938206673,
-0.017707927152514458,
-0.039186690002679825,
-0.0377083495259285,
0.0366799421608448,
0.015361867845058441,
0.03914383798837662,
0.034665971994400024,
0.008682562038302422,
0.012737280689179897,
-0.016968756914138794,
-0.03485880047082901,
-0.0020755662117153406,
0.014440583996474743,
-0.0027665288653224707,
0.014065642841160297,
-0.01848994754254818,
0.05891929939389229,
0.04944935813546181,
-0.02620301954448223,
0.0035271234810352325,
-0.049492210149765015,
0.055919770151376724,
-0.02311778999865055,
-0.048806603997945786,
-0.020364651456475258,
0.032652001827955246,
0.01971118338406086,
-0.0013558133505284786,
-0.019968286156654358,
-0.05561981722712517,
-0.021478762850165367,
-0.02800273522734642,
0.024081923067569733,
-0.011066115461289883,
-0.046578384935855865,
0.0003796277451328933,
-0.01179457176476717,
-0.006823925767093897,
-0.014890513382852077,
-0.03192354738712311,
-0.05112052708864212,
0.0024063177406787872,
0.045292872935533524,
0.027874184772372246,
0.025538837537169456,
-0.03252345323562622,
0.037215571850538254,
0.03076658584177494,
-0.007429187651723623,
0.02369626984000206,
-0.01881132461130619,
-0.0017019642982631922,
0.07455969601869583,
-0.00786304846405983,
-0.04486436769366264,
-0.01118395384401083,
-0.003580686403438449,
-0.044821515679359436,
-0.021275222301483154,
0.01995757222175598,
-0.003082550596445799,
0.006336502730846405,
0.04786389693617821,
-0.04452156275510788,
-0.01801859214901924,
-0.044607263058423996,
-0.03140934184193611,
-0.09212835878133774,
0.021200234070420265,
-0.048549503087997437,
0.00038498404319398105,
0.002111721085384488,
0.01946479268372059,
-0.009411018341779709,
-0.0030771943274885416,
-0.02986672706902027,
0.029052570462226868,
-0.01339074969291687,
0.021093107759952545,
-0.026074467226862907,
0.0366799421608448,
-0.006266871001571417,
0.03869390860199928,
-0.06157602369785309,
-0.012394477613270283,
0.009544926695525646,
0.0030102403834462166,
0.026224443688988686,
0.0015158328460529447,
-0.011483906768262386,
0.006550754886120558,
-0.007182797882705927,
0.024681828916072845,
-0.03218064829707146,
0.0036047897301614285,
0.09332817047834396,
-0.011612458154559135,
-0.01527616661041975,
0.004373418632894754,
-0.036208584904670715,
-0.021296648308634758,
-0.011441056616604328,
0.05981915444135666,
-0.021982254460453987,
0.01651882939040661,
0.01934695430099964,
-0.003974374383687973,
0.0008148271008394659,
0.004941186401993036,
-0.04150060936808586,
-0.004542142152786255,
-0.05223463475704193,
0.026288719847798347,
0.014258470386266708,
0.020600328221917152,
0.005305415019392967,
0.0021103820763528347,
0.03282340615987778,
0.015201179310679436,
-0.04966361075639725,
0.018822036683559418,
-0.020300377160310745,
-0.02693147584795952,
-0.0062186638824641705,
-0.024467578157782555,
0.0002827121934387833,
0.006363284308463335,
0.020439639687538147,
-0.033294759690761566,
-0.015115478076040745,
-0.013979942537844181,
-0.011537469923496246,
-0.006036549806594849,
0.05180613324046135,
-0.04456441476941109,
0.035351578146219254,
0.0060686878859996796,
0.018040018156170845,
-0.008628998883068562,
-0.04580707475543022,
0.021853704005479813,
0.0017501709517091513,
-0.07160301506519318,
-0.006925695575773716,
0.001980491913855076,
-0.002451846143230796,
0.02294638752937317,
-0.0098341666162014,
0.005924067460000515,
0.048378098756074905,
0.012844406999647617,
0.04167201370000839,
0.007584520615637302,
0.005666965153068304,
-0.0021010085474699736,
0.023203490301966667,
0.017472250387072563,
-0.030788011848926544,
-0.01845780946314335,
-0.058362241834402084,
0.007022108882665634,
0.016722368076443672,
0.004301108885556459,
0.021532325074076653,
0.017825765535235405,
0.06346143782138824,
0.014579848386347294,
0.03708701953291893,
-0.034558847546577454,
-0.04580707475543022,
0.01077151857316494,
0.02150018699467182,
0.012405190616846085,
0.02588164061307907,
0.003545870538800955,
-0.01261944230645895,
0.008248701691627502,
-0.0049170833081007,
-0.031537894159555435,
-0.039765167981386185,
-0.040086548775434494,
-0.01033765822649002,
0.043321751058101654,
0.005380403250455856,
-0.04169343784451485,
0.039186690002679825,
0.023931948468089104,
-0.02111453376710415,
-0.010380509309470654,
-0.026802923530340195,
0.03258772939443588,
0.019186265766620636,
-0.028988294303417206,
-0.054977063089609146,
0.02110382169485092,
-0.05292024090886116,
-0.018189994618296623,
-0.04400736093521118,
-0.03138791769742966,
0.0310879647731781,
-0.007198866922408342,
0.0024505071341991425,
-0.047092586755752563,
0.04160773754119873,
0.026288719847798347,
0.0568624772131443,
-0.03545870631933212,
0.02243218384683132,
0.018072156235575676,
-0.0094967195764184,
0.03783690184354782,
0.04846379905939102,
-0.04244332015514374,
-0.005924067460000515,
-0.036208584904670715,
-0.039936572313308716,
0.002169301500543952,
-0.029931003227829933,
0.011783859692513943,
0.019614769145846367,
-0.032544877380132675,
-0.006754294037818909,
-0.004614452365785837,
0.021425198763608932,
-0.015169041231274605,
0.03757980093359947,
-0.026374420151114464,
0.06701802462339401,
0.0005031574401073158,
0.009330674074590206,
0.010755450464785099,
-0.025581687688827515,
-0.02290353737771511,
0.012040961533784866,
0.046406980603933334,
-0.005353621672838926,
0.030166679993271828,
-0.028838317841291428,
0.06718942523002625,
-0.00480192294344306,
-0.04520716890692711,
0.0059669180773198605,
0.016711656004190445,
0.006743581499904394,
0.029716750606894493,
0.023353466764092445,
-0.00009591124398866668,
0.023931948468089104,
-0.030616609379649162,
-0.03545870631933212,
0.03910098969936371,
-0.05600547045469284,
-0.0281527116894722,
0.026802923530340195,
-0.024360451847314835,
0.028602641075849533,
-0.01916484162211418,
-0.00767557742074132,
0.036572813987731934,
0.030316656455397606,
0.08912882953882217,
-0.03447314724326134,
0.030573759227991104,
-0.05467711016535759,
-0.04692118614912033,
0.010514416731894016,
-0.0011710210237652063,
0.03702274337410927,
-0.010305521078407764,
-0.03119508922100067,
0.04824955016374588,
0.013926379382610321,
0.017204435542225838,
-0.004962611943483353,
0.011976686306297779,
0.02502463199198246,
-0.016711656004190445,
0.013819253072142601,
-0.019293392077088356,
-0.01734369806945324,
0.018575647845864296,
0.040943555533885956,
-0.044178761541843414,
-0.04576422646641731,
0.04760679230093956,
0.029073994606733322,
-0.029052570462226868,
-0.007905898615717888,
0.0088325385004282,
-0.02401764877140522,
0.048549503087997437,
-0.03757980093359947,
0.08724340796470642,
0.05596262216567993,
-0.018682774156332016,
-0.0038672485388815403,
-0.02096455730497837,
-0.02911684662103653,
-0.043278902769088745,
-0.007616658229380846,
-0.019121989607810974,
0.01780434139072895,
0.00739705003798008,
0.029952429234981537,
-0.025517411530017853,
0.0009011974325403571,
-0.004333246499300003,
0.014622698538005352,
0.0494065098464489,
-0.020910995081067085,
-0.03792260214686394,
-0.04293609783053398,
0.039400942623615265,
0.020053986459970474,
0.02193940430879593,
-0.013958517462015152,
-0.03967946767807007,
0.04154346138238907,
-0.008934307843446732,
0.008500447496771812,
-0.012769418768584728,
0.030038129538297653,
-0.0015385971637442708,
-0.005827654153108597,
-0.04893515631556511,
-0.03340188413858414,
0.06650381535291672,
-0.027959885075688362,
-0.0021344854030758142,
-0.010021637193858624,
-0.004453763365745544,
-0.016358138993382454,
0.0005396471824496984,
-0.03967946767807007,
0.009277110919356346,
-0.02661009691655636,
0.00709174107760191,
-0.011633883230388165,
-0.019357668235898018,
0.029502499848604202,
0.02326776646077633,
0.012437327764928341,
-0.0009875678224489093,
-0.013776402920484543,
-0.05022066831588745,
0.024146199226379395,
0.005372368730604649,
0.027274278923869133,
0.005956205539405346,
-0.0035913989413529634,
-0.007139947731047869,
0.02444615215063095,
-0.049063704907894135,
0.013647851534187794,
-0.00194567593280226,
0.0019831699319183826,
-0.031859271228313446,
0.021318072453141212,
-0.020686030387878418,
-0.01891845092177391,
0.0323949009180069,
0.03177357092499733,
0.006898913998156786,
-0.005891929846256971,
-0.02937394753098488,
0.01881132461130619,
-0.022239357233047485,
-0.003503020154312253,
-0.015361867845058441,
-0.009534213691949844,
0.006861419882625341,
0.010450140573084354,
-0.017311561852693558,
0.029738176614046097,
-0.0052705989219248295,
0.03260915353894234,
-0.022539310157299042,
-0.06603246182203293,
-0.011526756919920444,
0.010069843381643295,
0.0004827365337405354,
-0.06886059045791626,
0.02311778999865055,
0.005725884344428778,
0.02937394753098488,
-0.0006203264929354191,
-0.026267293840646744,
0.041157808154821396,
-0.00665252422913909,
0.011987399309873581,
0.018254268914461136,
-0.0038859955966472626,
-0.01769721508026123,
0.00026965621509589255,
0.005586620885878801,
0.006834638770669699,
0.02243218384683132,
0.011462481692433357,
0.01956120692193508,
0.024746105074882507,
0.0653897076845169,
0.01543685607612133,
0.04405020922422409,
-0.0010525129036977887,
0.03138791769742966,
-0.035201601684093475,
-0.02613874338567257,
0.03963661938905716,
-0.004515360575169325,
-0.012715855613350868,
-0.024060498923063278,
-0.04405020922422409,
-0.02018253691494465,
0.017354412004351616,
-0.012448040768504143,
-0.010118050500750542,
0.0029459649231284857,
-0.008714700117707253,
0.02455327846109867,
0.048335250467061996,
-0.030102405697107315,
-0.04589277505874634,
0.025538837537169456,
-0.04687833413481712,
-0.06299008429050446,
0.027959885075688362,
-0.02836696431040764,
-0.014783387072384357,
0.024960357695817947,
-0.011537469923496246,
-0.0049170833081007,
-0.03290910646319389,
0.022282207384705544,
-0.014301320537924767,
-0.04128636047244072,
0.016208162531256676,
-0.00018579665629658848,
0.01737583614885807,
0.004378775134682655,
0.0012513655237853527,
0.045507121831178665,
-0.0001891443389467895,
-0.032673429697752,
0.03359471261501312,
-0.01590820960700512,
0.042807549238204956,
-0.04979216307401657,
0.023074939846992493,
0.016818782314658165,
0.010401934385299683,
-0.00009674816828919575,
-0.013005095534026623,
-0.04075073078274727,
0.00667930580675602,
-0.009480650536715984,
-0.031537894159555435,
-0.020053986459970474,
0.02226078137755394,
-0.028131285682320595,
-0.009453869424760342,
0.008853963576257229,
0.0034789168275892735,
-0.010492991656064987,
-0.01816856861114502,
0.04000084847211838,
0.013455024920403957,
-0.003899386152625084,
-0.012169512920081615,
-0.0012774774804711342,
0.023246340453624725,
0.0008061231346800923,
-0.00020069385936949402,
-0.006898913998156786,
-0.013808540999889374,
0.010584047995507717,
-0.025860214605927467,
-0.015683244913816452,
-0.014601273462176323,
0.019186265766620636,
0.010005568154156208,
0.009989499114453793,
-0.03730127215385437,
-0.00038498404319398105,
-0.0036878124810755253,
-0.00931460503488779,
0.057676635682582855,
-0.0019791526719927788,
0.02714572660624981,
-0.005666965153068304,
-0.013744265772402287,
0.03018810600042343,
-0.008071944117546082,
-0.03629428893327713,
-0.019036289304494858,
0.01856493577361107,
-0.017065171152353287,
0.015372580848634243,
-0.018115006387233734,
-0.022753560915589333,
-0.01087864488363266,
0.0278956089168787,
0.01679735630750656,
-0.00893966481089592,
0.010819725692272186,
0.015158328227698803,
0.04495006799697876,
0.0032593084033578634,
-0.02965247631072998,
0.00955028273165226,
0.025303160771727562,
-0.0011187971103936434,
0.01977545954287052,
0.011023265309631824,
0.01123751699924469,
0.006775719113647938,
-0.029566774144768715,
0.003578008385375142,
0.001495746779255569,
-0.018822036683559418,
-0.0023982832208275795,
-0.04627843201160431,
-0.012458753772079945,
-0.008709343150258064,
0.03676564246416092,
0.007964817807078362,
-0.025795940309762955,
-0.01949693076312542,
0.0012138714082539082,
0.04807814583182335,
0.0007927323458716273,
-0.004542142152786255,
0.059004999697208405,
-0.016347426921129227,
-0.008907526731491089,
-0.0017153549706563354,
0.003401250345632434,
0.006925695575773716,
-0.014911938458681107,
-0.00806123111397028,
-0.009003940038383007,
0.020300377160310745,
-0.03627286106348038,
0.003433388192206621,
0.008382609114050865,
-0.012962245382368565,
-0.004970645997673273,
-0.03140934184193611,
0.02200368046760559,
0.02343916706740856,
0.009812741540372372,
0.006791788153350353,
0.003926167730242014,
0.0019055036827921867,
0.0435788556933403,
0.04884945601224899,
-0.015158328227698803,
0.022774986922740936,
-0.018907738849520683,
-0.008623642846941948,
0.002356771845370531,
0.0017394584137946367,
-0.003971696365624666,
-0.023032089695334435,
0.018211418762803078,
0.013112221844494343,
0.053048793226480484,
0.01917555369436741,
0.011473193764686584,
0.0026647590566426516,
0.0031977109611034393,
0.01561897061765194,
-0.0062990086153149605,
-0.02236790768802166,
-0.03166644275188446,
0.020450351759791374,
-0.01751510053873062,
-0.0008884762064553797,
-0.012030249461531639,
-0.03762264922261238,
-0.0030504127498716116,
0.009330674074590206,
0.014376308768987656,
0.02322491630911827,
0.00795410480350256,
-0.019904009997844696,
0.01963619515299797,
-0.005543770268559456,
-0.00985559169203043,
-0.039765167981386185,
-0.0015921600861474872,
0.010332302190363407,
-0.010182325728237629,
-0.01751510053873062,
-0.013829966075718403,
-0.0038190416526049376,
0.023182066157460213,
0.033337611705064774,
0.0008255396969616413,
-0.02423189952969551,
0.026802923530340195,
-0.013744265772402287,
-0.006234732922166586,
-0.0030798723455518484,
0.03593005985021591,
-0.012223076075315475,
-0.02178942784667015,
0.011623170226812363,
-0.004402878228574991,
-0.0039020644035190344,
0.008500447496771812,
-0.008639711886644363,
-0.007600589655339718,
0.032437752932310104,
-0.007504175882786512,
-0.014279895462095737,
-0.00191889435518533,
0.01748296245932579,
0.0046546244993805885,
0.0017675788840278983,
0.04392165690660477,
0.01690448261797428,
-0.030059553682804108,
0.039658043533563614,
-0.0014020114904269576,
-0.020868144929409027,
-0.019486218690872192,
-0.022774986922740936,
-0.028024161234498024,
-0.006159744691103697,
-0.0164759773761034,
0.025324584916234016,
-0.01060547400265932,
-0.03128078952431679,
-0.00795410480350256,
0.006406134460121393,
0.009818097576498985,
-0.022924963384866714,
-0.026760073378682137,
0.00787911657243967,
0.01913270354270935,
0.036101460456848145,
0.012640867382287979,
0.012587304227054119,
-0.014344170689582825,
-0.035158753395080566,
0.0051179444417357445,
0.005511632654815912,
-0.008966445922851562,
-0.011676733382046223,
0.009555638767778873,
-0.037108443677425385,
0.007284567691385746,
-0.03503020107746124,
-0.028174137696623802,
0.010991127230226994,
-0.008136219345033169,
0.0006625073147006333,
-0.014269182458519936,
0.0046546244993805885,
-0.023867672309279442,
0.006170457229018211,
-0.0047483597882092,
0.01410849392414093,
-0.010219819843769073,
-0.003821719903498888,
-0.0318806953728199,
-0.015415431000292301,
0.0239105224609375,
-0.02926682122051716,
-0.0024732714518904686,
-0.009571707807481289,
-0.002296513644978404,
0.021628739312291145,
-0.006165101192891598,
-0.02753138169646263,
0.0060686878859996796,
-0.015136903151869774,
-0.026695799082517624,
0.005693746730685234,
-0.002396944211795926,
0.01325148530304432,
0.007204223424196243,
0.01931481622159481,
-0.017011608928442,
-0.008216563612222672,
-0.008414747193455696,
0.03942236676812172,
-0.015811797231435776,
0.009502075612545013,
-0.03485880047082901,
0.03269485384225845,
0.0345374196767807,
-0.06491835415363312,
0.005758022423833609,
0.02154303714632988,
0.009427087381482124,
0.0045019700191915035,
-0.0028870454989373684,
-0.021746577695012093,
-0.0027959884610027075,
0.01549041923135519,
-0.04512146860361099,
-0.006914983037859201,
-0.005251851864159107,
0.017815053462982178,
-0.017782915383577347,
-0.01479410007596016,
-0.021350210532546043,
-0.032544877380132675,
-0.04512146860361099,
0.016400989145040512,
0.03290910646319389,
-0.00552770122885704,
0.00836654007434845,
-0.024510428309440613,
0.05934780091047287,
-0.011023265309631824,
0.01884346269071102,
0.014494147151708603,
0.006406134460121393,
-0.02847409062087536,
-0.036787066608667374,
-0.03813685476779938,
0.02571024000644684,
-0.003433388192206621,
0.040943555533885956,
-0.027081452310085297,
-0.013562151230871677,
0.021585887297987938,
-0.0002822100359480828,
-0.03033808246254921,
-0.008591504767537117,
-0.006700730882585049,
0.026074467226862907,
0.01946479268372059,
0.030745161697268486,
-0.02843123860657215,
-0.030638035386800766,
-0.04017224907875061,
-0.008136219345033169,
-0.015576119534671307,
-0.026267293840646744,
0.01874704845249653,
-0.02911684662103653,
-0.01923982799053192,
0.0039368802681565285,
0.0018264981918036938,
-0.0006350562907755375,
0.007750565651804209,
0.05806228891015053,
0.039979420602321625,
0.0030343439429998398,
-0.027445679530501366,
0.03044520877301693,
0.022774986922740936,
-0.02247503399848938,
-0.008382609114050865,
-0.009266398847103119,
-0.023631995543837547,
0.022774986922740936,
-0.03661566600203514,
0.008768262341618538,
-0.00847366638481617,
0.004635877441614866,
-0.03507304936647415,
0.028924018144607544,
-0.008784331381320953,
-0.027831334620714188,
0.004539464134722948,
0.014247757382690907,
-0.015019064769148827,
0.014644123613834381,
-0.030273806303739548,
-0.014869088307023048,
0.008029093034565449,
0.029031144455075264,
-0.005865148268640041,
-0.00438948767259717,
-0.02560311369597912,
0.019732609391212463,
-0.001416741288267076,
-0.013455024920403957,
0.006116894539445639,
0.005045634228736162,
-0.0007137269712984562,
-0.004930473864078522,
0.03749409690499306,
0.006807857193052769,
-0.03543727844953537,
0.006181169766932726,
-0.00961991399526596,
-0.006138319615274668,
0.04490721598267555,
-0.031109388917684555,
-0.01841495931148529,
-0.022732136771082878,
0.002011290518566966,
0.013572863303124905,
-0.0005865148268640041,
0.017461536452174187,
0.01702232100069523,
-0.014869088307023048,
0.029566774144768715,
-0.030466632917523384,
0.020878857001662254,
-0.024896081537008286,
-0.0008228615624830127,
-0.039615191519260406,
0.02061104215681553,
0.012212364003062248,
0.018211418762803078,
-0.015029776841402054,
0.08921452611684799,
0.018586359918117523,
-0.01867206022143364,
-0.00698461476713419,
0.005163473077118397,
-0.014065642841160297,
0.02438187599182129,
0.0027799196541309357,
-0.007059602998197079,
-0.003489629365503788,
0.02560311369597912,
-0.03755837306380272,
0.019936148077249527,
0.01044478453695774,
-0.003208423499017954,
0.042850397527217865,
0.007070315536111593,
0.040150824934244156,
0.037108443677425385,
0.01554398238658905,
0.011537469923496246,
-0.025945916771888733,
-0.02438187599182129,
-0.01745082437992096,
0.04160773754119873,
-0.021778715774416924,
-0.018532797694206238,
0.002640655729919672,
0.016743794083595276,
0.011944548226892948,
0.004191304557025433,
0.017943603917956352,
0.03862963244318962,
0.029931003227829933,
0.003765478730201721,
-0.008457597345113754,
0.03282340615987778,
0.00942173134535551,
-0.024981781840324402,
-0.005597333423793316,
-0.036572813987731934,
0.02290353737771511,
-0.017204435542225838,
-0.012094524689018726,
-0.012255214154720306,
-0.014344170689582825,
0.0022924963850528,
0.0038190416526049376,
0.03916526585817337,
-0.008163000456988811,
0.0045287515968084335,
-0.05806228891015053,
0.04983501508831978,
-0.023310616612434387,
-0.027552805840969086,
0.009678834117949009,
0.0021210946142673492,
0.009555638767778873,
-0.00021441937133204192,
-0.015929635614156723,
-0.036358561366796494,
0.001110093086026609,
0.000263965135673061,
0.011612458154559135,
0.02825983799993992,
-0.06727512925863266,
0.0002567676128819585,
-0.034451719373464584,
-0.020803868770599365,
0.0024304210674017668,
0.001460930798202753,
-0.0063525717705488205,
0.03119508922100067,
0.03198782354593277,
0.008709343150258064,
-0.01870419830083847,
-0.018586359918117523,
0.03543727844953537,
-0.01410849392414093,
-0.003012918634340167,
-0.07254572212696075,
0.02793845906853676,
0.037536948919296265,
-0.015822509303689003,
-0.004526073113083839,
0.010359084233641624,
0.005747309885919094,
-0.02182156592607498,
-0.01874704845249653,
0.06448984891176224,
-0.0011917767114937305,
0.0722457692027092,
-0.01665809191763401,
0.009641340002417564,
0.017761489376425743,
-0.014601273462176323,
0.0008215224952436984,
-0.026867199689149857,
-0.02100740745663643,
0.02438187599182129,
-0.03704417124390602,
-0.049749311059713364,
0.026053043082356453,
0.02204653061926365,
-0.01622958853840828,
0.03263057768344879,
0.026952899992465973,
0.024039072915911674,
-0.013679989613592625,
0.012490890920162201,
-0.019089853391051292,
0.047906745225191116,
0.014815525151789188,
0.013144359923899174,
0.027809908613562584,
0.034665971994400024,
-0.00039301850483752787,
-0.025003207847476006,
0.010364440269768238,
-0.0042957523837685585,
0.051677580922842026,
0.049492210149765015,
-0.0225821603089571,
-0.059862006455659866,
-0.0187363363802433,
0.0028361608274281025,
0.07190296798944473,
-0.026117317378520966,
-0.010809012688696384,
-0.03196639567613602,
-0.006748937536031008,
0.029716750606894493,
0.0025951273273676634,
0.022860687226057053,
0.04850665107369423,
-0.0009440478170290589,
-0.003690490499138832,
0.0038458232302218676,
0.030788011848926544,
0.0098341666162014,
0.01609032414853573,
-0.00881111342459917,
-0.019646907225251198,
0.008323689922690392,
-0.0031334355007857084,
-0.0004696805262938142,
-0.022517884150147438,
-0.010059131309390068,
0.009700259193778038,
-0.0028843674808740616,
-0.00996271800249815,
0.010691174305975437,
-0.010851863771677017,
-0.007391693536192179,
0.015843935310840607,
0.01344431284815073,
-0.013069371692836285,
-0.008709343150258064,
-0.026952899992465973,
-0.01630457676947117,
-0.024060498923063278,
-0.010091268457472324,
-0.009941291995346546,
0.006861419882625341,
0.009464581497013569,
0.036058612167835236,
0.015222604386508465,
-0.015201179310679436,
0.016647379845380783,
-0.013872816227376461,
-0.03348758816719055,
0.02150018699467182,
-0.02858121506869793,
-0.0033503654412925243,
0.00019751355284824967,
-0.033980365842580795,
0.0002954334195237607,
-0.000038895941543160006,
-0.025367435067892075,
-0.022753560915589333,
-0.002684845356270671,
0.03220207616686821,
-0.018147144466638565,
-0.000609948649071157,
-0.003267342923209071,
0.0029539994429796934,
-0.031323641538619995,
-0.01867206022143364,
0.028945444151759148,
0.013187210075557232,
-0.06560395658016205,
0.02646012045443058,
0.025731664150953293,
0.014911938458681107,
0.0057098157703876495,
0.00972704030573368,
-0.006904270499944687,
0.020546765998005867,
0.022882113233208656,
0.012608729302883148,
0.001100050052627921,
0.009641340002417564,
0.013165784999728203,
-0.012319489382207394,
-0.049235109239816666,
-0.00831297691911459,
0.02183227799832821,
-0.03168787062168121,
-0.020236101001501083,
-0.007006040308624506,
0.015886785462498665,
-0.011494619771838188,
0.008730768226087093,
-0.01684020645916462,
0.012405190616846085,
0.00698461476713419,
0.009518144652247429,
-0.0297596026211977,
0.011944548226892948,
0.021082395687699318,
0.019646907225251198,
0.011462481692433357,
0.0008777636103332043,
0.009577063843607903,
0.026267293840646744,
-0.005101875402033329,
0.005907998885959387,
0.001963083865121007,
0.0017193722305819392,
-0.02825983799993992,
0.044393014162778854,
-0.03443029522895813,
-0.04126493260264397,
0.03299480676651001,
0.03680849075317383,
0.003794938325881958,
-0.0047081876546144485,
0.03500877693295479,
-0.015179753303527832,
-0.008050519041717052,
-0.02847409062087536,
0.014194194227457047,
0.01888631284236908,
-0.042314767837524414,
-0.0035485485568642616,
0.02832411415874958,
-0.017097309231758118,
0.0011649952502921224,
-0.009716328233480453,
-0.002396944211795926,
-0.001565378624945879,
0.008537941612303257,
-0.03882246091961861,
0.006834638770669699,
0.0039100986905395985,
0.013272911310195923,
0.055705517530441284,
0.009823453612625599,
-0.025196034461259842,
0.02650297060608864,
-0.005337552633136511,
-0.012758705765008926,
-0.012833693996071815,
-0.010091268457472324,
-0.02035393938422203,
-0.01490122638642788,
-0.01845780946314335,
-0.002492018509656191,
0.011837422847747803,
-0.007231004536151886,
0.01844709739089012,
-0.026760073378682137,
0.024146199226379395,
-0.016068900004029274,
-0.014044217765331268,
0.010080556385219097,
-0.011698158457875252,
-0.008462953381240368,
-0.03680849075317383,
0.031366489827632904,
-0.03935809060931206,
0.0023420420475304127,
0.010284096002578735,
-0.010155544616281986,
0.020514627918601036,
0.0022188471630215645,
0.017365124076604843,
-0.0012419919949024916,
0.006390065886080265,
0.027445679530501366,
0.0018880956340581179,
0.0034521352499723434,
-0.05317734554409981,
0.051720429211854935,
-0.03125936537981033,
0.005854435730725527,
0.016508115455508232,
-0.02954535000026226,
-0.015372580848634243,
-0.020011136308312416,
0.02028966322541237,
-0.021982254460453987,
0.008377253077924252,
-0.0023246342316269875,
-0.01985044777393341,
0.01110896561294794,
0.009593132883310318,
0.0032111017499119043,
-0.0028441951144486666,
0.004534107632935047,
0.025174608454108238,
0.023417742922902107,
-0.01830783300101757,
-0.01113039068877697,
-0.038072578608989716,
0.01820070669054985,
-0.011869559995830059,
-0.010316233150660992,
-0.019229115918278694,
0.007022108882665634,
0.01655096560716629,
0.004804600961506367,
0.047049738466739655,
0.016101038083434105,
0.02933109737932682,
-0.008184426464140415,
-0.023739119991660118,
-0.019196977838873863,
0.026010191068053246,
0.026395846158266068,
0.009785959497094154,
0.011815997771918774,
0.023996222764253616,
-0.0060151247307658195,
-0.013144359923899174,
-0.0006450993823818862,
-0.008457597345113754,
0.011687446385622025,
0.034515995532274246,
0.017579376697540283,
-0.04077215492725372,
-0.029202546924352646,
0.006057974882423878,
-0.00634721526876092,
0.005200967192649841,
0.029459649696946144,
-0.01351930107921362,
0.0022402724716812372,
-0.025474561378359795,
0.016133174300193787,
-0.0025696847587823868,
0.011526756919920444,
-0.004014546517282724,
-0.0024116740096360445,
0.011698158457875252,
-0.020418215543031693,
0.05300594121217728,
0.0065775359980762005,
0.005203645210713148,
-0.008912882767617702,
-0.03880103677511215,
0.018939876928925514,
-0.0025696847587823868,
-0.017429400235414505,
0.00922354869544506,
0.008928951807320118,
-0.005784804001450539,
-0.029609626159071922,
0.042957525700330734,
-0.014408446848392487,
-0.012040961533784866,
0.011998111382126808,
-0.026395846158266068,
-0.019004151225090027,
-0.011194666847586632,
0.01195526123046875,
-0.00018931171507574618,
0.00958242081105709,
0.003669065423309803,
-0.027402829378843307,
-0.0059401364997029305,
0.020943133160471916,
0.030788011848926544,
0.007514888420701027,
-0.015233316458761692,
0.01565110869705677,
-0.057890888303518295,
-0.06787502765655518,
-0.01344431284815073,
0.00367174344137311,
-0.015586832538247108,
0.029631050303578377,
-0.02343916706740856,
0.049749311059713364,
0.051720429211854935,
-0.01812571845948696,
-0.001814446528442204,
0.04876375198364258,
-0.003055769018828869,
-0.014258470386266708,
-0.009057503193616867,
0.008259414695203304,
0.042379043996334076,
-0.02481038123369217,
-0.007600589655339718,
-0.015072627924382687,
-0.0003190346178598702,
0.012030249461531639,
-0.008457597345113754,
0.007643439806997776,
0.05733383446931839,
0.00770235899835825,
0.008762906305491924,
0.009234260767698288,
-0.035565830767154694,
0.027017176151275635,
-0.023996222764253616,
-0.00028572510927915573,
0.0032512738835066557,
-0.023867672309279442,
-0.03672279044985771,
0.006673949770629406,
0.02821698784828186,
-0.019411230459809303,
-0.003955627325922251,
0.01062689907848835,
0.009207479655742645,
-0.028388388454914093,
-0.010916138999164104,
0.006561467424035072,
0.03545870631933212,
-0.011248230002820492,
-0.014333458617329597,
-0.021350210532546043,
-0.04426446184515953,
-0.006673949770629406,
-0.00022831227397546172,
0.0038458232302218676,
-0.028945444151759148,
0.019861159846186638,
0.00858079269528389,
-0.013005095534026623,
0.004933152347803116,
0.005125978961586952,
0.01891845092177391,
0.03316620737314224,
-0.023139216005802155,
-0.01644384115934372,
-0.039872296154499054,
-0.010476922616362572,
-0.024788955226540565,
-0.005184898152947426,
-0.03524445369839668,
0.015179753303527832,
0.005774090997874737,
0.009153916500508785,
-0.012276639230549335,
0.011312505230307579,
-0.01774006523191929,
-0.05077772215008736,
-0.018543509766459465,
0.014483435079455376,
-0.01195526123046875,
0.027274278923869133,
0.012405190616846085,
-0.024189049378037453,
0.006813213229179382,
-0.013080083765089512,
-0.0209966953843832,
0.0008784331730566919,
-0.049749311059713364,
-0.01471911184489727,
0.00207288796082139,
-0.005008140113204718,
-0.004271649289876223,
0.0409221313893795,
0.009646696038544178,
0.0361228846013546,
-0.005361656192690134,
0.0033209058456122875,
0.00913784746080637,
0.023674845695495605,
-0.008387965150177479,
-0.019839733839035034,
-0.011098253540694714,
0.004962611943483353,
-0.0034574915189296007,
-0.006914983037859201,
-0.021693013608455658,
0.0006658550119027495,
-0.0225821603089571,
0.02056819200515747,
-0.010809012688696384,
0.007734497077763081,
0.012383765541017056,
0.021810851991176605,
-0.04846379905939102,
0.008205851539969444,
0.004576958250254393,
0.03389466553926468,
0.017279423773288727,
0.03449457138776779,
-0.03586578369140625,
0.00877897534519434,
-0.015372580848634243,
0.041736289858818054,
-0.018822036683559418,
0.003551226807758212,
0.05450570583343506,
-0.020846718922257423,
-0.03676564246416092,
0.007804128807038069,
0.021885840222239494,
-0.026738649234175682,
0.000741177995223552,
-0.022667860612273216,
-0.013594289310276508,
-0.005891929846256971,
-0.031752146780490875,
0.02986672706902027,
0.026117317378520966,
0.006052618846297264,
0.0019309461349621415,
0.00842010322958231,
-0.05022066831588745,
0.005029565654695034,
-0.017504388466477394,
-0.02980245277285576,
0.0056830341927707195,
-0.012351627461612225,
-0.0025911100674420595,
-0.007921967655420303,
-0.001893452019430697,
0.01888631284236908,
0.028709767386317253,
-0.0026219086721539497,
-0.01629386469721794,
0.0059347799979150295,
-0.03181641921401024,
0.0014743214705958962,
0.018436383455991745,
-0.0013571524759754539,
-0.01609032414853573,
0.009143203496932983,
-0.011494619771838188,
-0.013187210075557232,
0.02650297060608864,
0.04554997384548187,
-0.010198394767940044,
-0.000469010992674157,
-0.01026802696287632,
0.005774090997874737,
-0.033551860600709915,
-0.01812571845948696,
0.11800999939441681,
-0.04096497967839241,
-0.001464947941713035,
-0.007075672037899494,
-0.012951533310115337,
-0.011976686306297779,
0.01870419830083847,
0.0056294710375368595,
0.007766634691506624,
-0.012469465844333172,
0.015008351765573025,
0.007097097113728523,
0.022239357233047485,
0.013262198306620121,
0.034408871084451675,
-0.014354883693158627,
0.0012453397503122687,
0.04966361075639725,
-0.005870504770427942,
-0.0005985664902254939,
0.02577451430261135,
0.03777262568473816,
-0.018939876928925514,
0.024189049378037453,
-0.019186265766620636,
0.01466554868966341,
-0.016593817621469498,
0.006722156424075365,
-0.012426615692675114,
-0.02491750754415989,
0.010937564074993134,
0.010369796305894852,
0.0348159484565258,
-0.02369626984000206,
-0.0069953277707099915,
-0.014622698538005352,
0.013090796768665314,
0.009394950233399868,
-0.003690490499138832,
0.03554440662264824,
0.0011743687791749835,
0.037794049829244614,
0.009239616803824902,
0.0030664815567433834,
0.013926379382610321,
0.01556540746241808,
-0.028452664613723755,
0.016004623845219612,
0.003353043692186475,
-0.008441528305411339,
-0.0028790112119168043,
-0.005522345192730427,
0.0174079742282629,
-0.04038650169968605,
-0.017118733376264572,
-0.0007251090719364583,
0.022710710763931274,
0.011087540537118912,
-0.0520632341504097,
-0.009036078117787838,
0.015501131303608418,
-0.007857691496610641,
-0.0073006367310881615,
-0.0039100986905395985,
0.00900929607450962
] | 2025-01-09 | 1 | 39786986 | [
"T cell therapies",
"T cells",
"T cell receptor",
"cancer cells",
"T cell-based therapies",
"additional effector populations",
"TME",
"Tumor Infiltrating Lymphocyte Therapy",
"CAR T",
"TCR T",
"powerful therapeutic approaches",
"cancer treatment",
"Chimeric Antigen",
"toxicity",
"resistance",
"action",
"evidence",
"TIL",
"efficacy",
"clinical and preclinical data",
"their direct cytotoxic effects",
"these therapies",
"safety",
"the antitumor immune response",
"the TME",
"the cytokine milieu",
"a better understanding",
"the tumor microenvironment",
"the bidirectional influences",
"the goal"
] | [] | 0 | 10.1158/2326-6066.CIR-24-0857 | [
"Pherez-Farah",
"Boncompagni",
"Chudnovskiy",
"Pasqual"
] | [
"University of Padua, Padua, Italy.",
"University of Padua, Padua, 35128, Italy.",
"The Francis Crick Institute, United Kingdom.",
"University of Padua, Padua, PD, Italy."
] | [
"39786986"
] | [] | 10.227115 | 4.837266 |
39785827 | 53 | TBK1 Targeting Is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids. | Novel therapeutic strategies are needed to improve the efficacy of chimeric antigen receptor (CAR) T cells as a treatment of solid tumors. Multiple tumor microenvironmental factors are thought to contribute to resistance to CAR T-cell therapy in solid tumors, and appropriate model systems to identify and examine these factors using clinically relevant biospecimens are limited. In this study, we examined the activity of B7-H3-directed CAR T cells (B7-H3.CAR-T) using 3D microfluidic cultures of patient-derived organotypic tumor spheroids (PDOTS) and then confirmed the activity of B7-H3.CAR T cells in PDOTS. Although B7-H3 expression in PDOTS was associated with B7-H3.CAR-T sensitivity, mechanistic studies revealed dynamic upregulation of co-inhibitory receptors on CAR T-cells following target cell encounter that led to CAR T-cell dysfunction and limited efficacy against B7-H3-expressing tumors. PD-1 blockade restored CAR T-cell activity in monotypic and organotypic tumor spheroids with improved tumor control and upregulation of effector cytokines. Given the emerging role of TANK-binding kinase 1 (TBK1) as an immune evasion gene, we examined the effect of TBK1 inhibition on CAR T-cell efficacy. Similar to PD-1 blockade, TBK1 inhibition restored CAR T-cell activity in monotypic and organotypic tumor spheroids, prevented CAR T-cell dysfunction, and enhanced CAR T-cell proliferation. Inhibition or deletion of TBK1 also enhanced the sensitivity of cancer cells to immune-mediated killing. Taken together, our results demonstrate the feasibility and utility of ex vivo profiling of CAR T cells using PDOTS and suggest that targeting TBK1 could be used to enhance CAR T-cell efficacy by overcoming tumor-intrinsic and -extrinsic resistance mechanisms. | [
0.0028694644570350647,
-0.012481944635510445,
0.0498315803706646,
0.058056674897670746,
-0.023184191435575485,
-0.03239533677697182,
-0.009571895934641361,
0.031481437385082245,
-0.011459819972515106,
-0.017724841833114624,
-0.010497820563614368,
-0.0069504473358392715,
-0.00871812179684639,
-0.033814284950494766,
0.02669548988342285,
-0.0026364801451563835,
0.058730076998472214,
-0.0002801447990350425,
0.029220737516880035,
0.03239533677697182,
0.036724336445331573,
-0.011279445141553879,
-0.013876844197511673,
0.03203458711504936,
-0.02501199021935463,
0.02190954051911831,
0.016510318964719772,
0.00045657402370125055,
0.004359060898423195,
-0.015452118590474129,
0.026960039511322975,
-0.01701536774635315,
-0.06382867693901062,
-0.033862385898828506,
-0.03783063590526581,
0.022907614707946777,
0.04482918232679367,
0.021296266466379166,
-0.004803985357284546,
-0.014201519079506397,
0.045983582735061646,
0.022534841671586037,
0.0005073045031167567,
0.10264535993337631,
-0.052092280238866806,
-0.011105082929134369,
-0.013179394416511059,
-0.030904237180948257,
0.01402114424854517,
0.005423272959887981,
-0.027561288326978683,
-0.0018593649147078395,
-0.003932173363864422,
0.01750839315354824,
-0.05704657733440399,
0.03354973718523979,
-0.020382367074489594,
-0.0007692239014431834,
-0.016233744099736214,
0.04535828158259392,
0.012830669991672039,
-0.005375172942876816,
0.04754683002829552,
-0.023629115894436836,
-0.04648863151669502,
-0.009686133824288845,
-0.0531504787504673,
-0.05824907496571541,
-0.008032696321606636,
0.018758991733193398,
0.007142846938222647,
-0.009469683282077312,
-0.007695996668189764,
0.014417968690395355,
0.05560357868671417,
0.00087406684178859,
0.032876335084438324,
-0.0016895118169486523,
0.009998783469200134,
-0.014417968690395355,
0.03843188285827637,
-0.006045566406100988,
0.02724863961338997,
-0.0331408865749836,
-0.0036826548166573048,
-0.015416043810546398,
-0.0029190676286816597,
-0.04232798144221306,
-0.05387197807431221,
0.0036766421981155872,
0.016257792711257935,
-0.0033399423118680716,
-0.026094239205121994,
0.06724376976490021,
0.014898968860507011,
0.0031264987774193287,
-0.03256368637084961,
-0.07720046490430832,
0.02727268822491169,
0.02873973734676838,
0.024867689236998558,
-0.003099442459642887,
-0.03506488725543022,
0.00838142167776823,
0.04013943299651146,
0.033597834408283234,
-0.037349633872509,
0.001769177382811904,
0.016378043219447136,
-0.009000709280371666,
0.10485795885324478,
-0.007269109599292278,
-0.0188792422413826,
0.04826832935214043,
-0.016149569302797318,
-0.04249633103609085,
-0.03107258677482605,
0.012127207592129707,
-0.02116399072110653,
0.005940347444266081,
0.005254922900348902,
0.03189028799533844,
0.037493932992219925,
-0.012049045413732529,
0.008477621711790562,
-0.030615637078881264,
0.06839817017316818,
-0.037517983466386795,
-0.04920627921819687,
-0.058056674897670746,
0.02806633897125721,
0.004341023042798042,
0.02347278967499733,
-0.0024530990049242973,
-0.028403038159012794,
-0.008062759414315224,
-0.021392466500401497,
0.009331395849585533,
-0.019528592005372047,
-0.01446606870740652,
-0.009445633739233017,
-0.0034181049559265375,
0.009896570816636086,
-0.005820097401738167,
-0.06450207531452179,
-0.051226478070020676,
0.012746495194733143,
0.015440093353390694,
-0.00015632493887096643,
0.07614226639270782,
-0.008676034398376942,
0.02578158862888813,
0.06483877450227737,
-0.015223643742501736,
0.01676284335553646,
-0.032996587455272675,
0.014646444469690323,
0.07498786598443985,
-0.02503603883087635,
-0.03847998380661011,
-0.033381387591362,
0.004879141692072153,
-0.0410773828625679,
-0.0015452118823304772,
0.0017225805204361677,
0.016834992915391922,
-0.013167369179427624,
0.028282787650823593,
-0.0755169689655304,
-0.03157763555645943,
-0.01738814264535904,
-0.029076438397169113,
-0.08066366612911224,
0.003141529858112335,
-0.07037027180194855,
0.010052896104753017,
-0.0083453468978405,
0.02081526629626751,
0.010870595462620258,
-0.0017000336665660143,
-0.01566856913268566,
0.016654618084430695,
0.04242418333888054,
0.0037127172108739614,
-0.0038960983511060476,
0.0256853885948658,
-0.022594965994358063,
0.024086065590381622,
-0.030014388263225555,
-0.017712818458676338,
0.01872291788458824,
-0.006914372090250254,
0.07263097167015076,
-0.000858284009154886,
0.010612058453261852,
-0.028330888599157333,
0.003165579866617918,
0.018422292545437813,
-0.021993715316057205,
0.0023944771382957697,
0.03179408609867096,
-0.017123593017458916,
-0.03944198414683342,
-0.023412665352225304,
-0.022462690249085426,
-0.0063371723517775536,
-0.027128389105200768,
0.01323951967060566,
-0.015079343691468239,
0.006788109894841909,
0.034631986171007156,
0.00857983436435461,
-0.022667115554213524,
0.04090903326869011,
-0.004761897958815098,
-0.04607978090643883,
-0.036002837121486664,
0.04870123043656349,
0.009108933620154858,
0.035305384546518326,
-0.019492516294121742,
0.01946846768260002,
0.004335010889917612,
0.03318898752331734,
-0.0037968922406435013,
-0.003950210753828287,
-0.008020672015845776,
-0.029292888939380646,
0.001102541689760983,
-0.031409285962581635,
0.0004069709393661469,
0.01857861690223217,
0.04935057833790779,
-0.007954534143209457,
-0.024398714303970337,
0.007840297184884548,
0.025565139949321747,
0.004587535746395588,
0.03821543604135513,
-0.044468432664871216,
0.01748434267938137,
0.015524269081652164,
-0.013660394586622715,
-0.017231818288564682,
-0.00539621664211154,
0.008219083771109581,
0.006138760130852461,
-0.07325626909732819,
-0.038383785635232925,
-0.026863839477300644,
-0.001283668214455247,
-0.015464143827557564,
-0.04579118266701698,
-0.01713561825454235,
0.004518392030149698,
0.0211880411952734,
0.06022117659449577,
-0.0037517985329031944,
-0.004196723457425833,
-0.023412665352225304,
-0.0037277485243976116,
0.012746495194733143,
-0.009451646357774734,
-0.035329435020685196,
-0.05848957598209381,
0.004115554504096508,
-0.010215233080089092,
0.01063009537756443,
0.03893693536520004,
-0.02876378782093525,
0.0641653761267662,
0.007124809548258781,
0.024458840489387512,
-0.03167383745312691,
-0.05242897942662239,
0.008676034398376942,
-0.026935989037156105,
0.042111534625291824,
-0.010557945817708969,
0.008056746795773506,
-0.0010905166855081916,
0.03867238387465477,
0.009818408638238907,
-0.010155108757317066,
-0.023653164505958557,
-0.008152946829795837,
0.022510791197419167,
0.012674344703555107,
-0.007118796929717064,
-0.02165701612830162,
0.044420331716537476,
0.004560479428619146,
-0.01596919260919094,
-0.008525721728801727,
-0.02039439231157303,
-0.011309508234262466,
-0.0029641613364219666,
-0.044348180294036865,
-0.030567537993192673,
0.006021516397595406,
-0.039874885231256485,
0.0032016548793762922,
-0.03278013691306114,
-0.015379969030618668,
0.02744103968143463,
0.003640567185357213,
0.013155344873666763,
-0.015500218607485294,
0.024398714303970337,
0.0316016860306263,
0.01922796666622162,
-0.024506939575076103,
-0.0038900859653949738,
0.042977333068847656,
0.00912697147578001,
0.00039983110036700964,
0.029773887246847153,
-0.02305191569030285,
0.02433858998119831,
-0.02797013893723488,
-0.08133706450462341,
-0.021320316940546036,
-0.056517478078603745,
0.002138945972546935,
0.048893630504608154,
-0.01907164230942726,
0.011327545158565044,
0.001994646154344082,
0.017051443457603455,
-0.03181813657283783,
0.015043268911540508,
-0.021091841161251068,
0.048124030232429504,
-0.016474243253469467,
-0.006126734893769026,
-0.02890808880329132,
-0.02384556457400322,
-0.0163660179823637,
0.014550244435667992,
0.03727748617529869,
-0.021031716838479042,
0.042231783270835876,
-0.033766187727451324,
0.033766187727451324,
-0.007413409650325775,
0.016919167712330818,
0.009854483418166637,
0.017845092341303825,
0.01061807107180357,
0.02503603883087635,
0.041341934353113174,
0.027873938903212547,
0.003902110969647765,
0.004380104597657919,
-0.0035293360706418753,
0.015091368928551674,
-0.038239482790231705,
-0.023665189743041992,
0.028403038159012794,
0.010371558368206024,
0.033381387591362,
0.007112784776836634,
-0.034439586102962494,
0.03797493502497673,
0.07484357059001923,
0.0639248713850975,
-0.057383276522159576,
0.020406417548656464,
-0.05387197807431221,
-0.03422313556075096,
-0.009325383231043816,
0.0016068399418145418,
0.020238066092133522,
0.010762370191514492,
-0.026310689747333527,
0.03958628326654434,
0.012698395177721977,
0.03345353528857231,
-0.002435061614960432,
-0.012253469787538052,
0.05161127820611,
-0.021741190925240517,
0.014490119181573391,
-0.02570943906903267,
0.011044957675039768,
0.0024440803099423647,
0.06094267591834068,
-0.013516094535589218,
-0.08148136734962463,
0.021103866398334503,
0.02510819025337696,
0.01523566897958517,
0.03417503461241722,
-0.00036695023300126195,
-0.015632493421435356,
0.047306329011917114,
-0.030014388263225555,
0.07258287072181702,
0.05945157632231712,
0.018097616732120514,
-0.01151393260806799,
-0.021248165518045425,
-0.021296266466379166,
-0.019889341667294502,
0.022787366062402725,
-0.011718357913196087,
0.058056674897670746,
0.0007481801440007985,
0.017424218356609344,
-0.0022246241569519043,
0.005077554378658533,
-0.04757088050246239,
0.015247694216668606,
0.011231345124542713,
0.028306838124990463,
-0.028475187718868256,
-0.05218847841024399,
0.03559398651123047,
0.0032317175064235926,
0.04331403225660324,
-0.021176015958189964,
-0.03893693536520004,
0.020707041025161743,
-0.0388888344168663,
-0.013732544146478176,
0.044324133545160294,
0.03205863758921623,
0.0022817428689450026,
0.00869407132267952,
-0.08239526301622391,
-0.02076716721057892,
0.04834048077464104,
0.0009574902360327542,
-0.03119283728301525,
-0.024037964642047882,
-0.0050504980608820915,
-0.025589190423488617,
0.01333571970462799,
-0.03807113319635391,
0.02717648819088936,
-0.04312163218855858,
0.0017827055417001247,
-0.003781860927119851,
-0.04923032969236374,
0.04066853225231171,
-0.02160891704261303,
0.03256368637084961,
-0.029268838465213776,
-0.012878770008683205,
-0.03136118873953819,
-0.025372739881277084,
-0.0018638742621988058,
-0.021524740383028984,
0.022594965994358063,
-0.005215841811150312,
-0.006439385004341602,
0.03867238387465477,
-0.05286187678575516,
-0.017051443457603455,
0.008152946829795837,
0.04826832935214043,
-0.003989292308688164,
0.009764296002686024,
-0.021717140451073647,
-0.022318391129374504,
0.04066853225231171,
0.03340543806552887,
-0.012818644754588604,
-0.00231030210852623,
-0.043650731444358826,
0.00838142167776823,
-0.008092821575701237,
-0.019889341667294502,
0.0016910149715840816,
-0.04259253293275833,
0.014706568792462349,
0.00502344174310565,
-0.005161729175597429,
0.007503597065806389,
0.024867689236998558,
0.004698766861110926,
-0.014514168724417686,
-0.045959532260894775,
0.013383819721639156,
0.06878297030925751,
0.03869643434882164,
-0.02885998785495758,
-0.01212119497358799,
-0.039730582386255264,
0.0478835292160511,
-0.017376117408275604,
-0.02374936453998089,
0.03186623752117157,
-0.011357608251273632,
-0.002982198726385832,
-0.01564451865851879,
0.015295793302357197,
-0.007437459658831358,
0.005528491456061602,
0.019264042377471924,
0.016931192949414253,
0.03164978697896004,
0.015752743929624557,
0.0006703934632241726,
0.042808983474969864,
0.030711837112903595,
0.007840297184884548,
0.043626680970191956,
0.017917241901159286,
0.012217395007610321,
-0.04408363252878189,
-0.038311634212732315,
0.014634419232606888,
0.0017436243360862136,
-0.011531970463693142,
-0.021248165518045425,
-0.07181327044963837,
-0.03157763555645943,
-0.004632629454135895,
0.006914372090250254,
-0.028619488701224327,
-0.019660867750644684,
0.005750953685492277,
0.03405478596687317,
0.027657488361001015,
-0.050312578678131104,
-0.03131308779120445,
-0.035377535969018936,
-0.03893693536520004,
-0.050456877797842026,
0.03662813454866409,
-0.03112068772315979,
0.026743588969111443,
0.009205133654177189,
0.0010506839025765657,
-0.009698158130049706,
-0.014514168724417686,
0.013973044231534004,
-0.012211382389068604,
-0.03285228833556175,
0.04401148110628128,
-0.009030771441757679,
-0.001333271386101842,
-0.00015867357433307916,
0.02018996700644493,
0.018891267478466034,
0.0024530990049242973,
-0.024470865726470947,
0.009505758993327618,
-0.008243134245276451,
0.032154835760593414,
-0.03350163623690605,
-0.008333321660757065,
0.027056239545345306,
0.004010336007922888,
-0.010569971054792404,
0.007263096980750561,
-0.015319843776524067,
-0.007521634455770254,
-0.006577672436833382,
-0.016005268320441246,
0.012247457168996334,
0.03352568671107292,
-0.03932173550128937,
-0.00414261082187295,
0.020995641127228737,
0.005513460375368595,
-0.01198290754109621,
-0.027609389275312424,
0.03653193637728691,
-0.021969666704535484,
0.008056746795773506,
-0.0046025668270885944,
-0.024891739711165428,
0.056517478078603745,
-0.007870359346270561,
-0.01564451865851879,
0.01131551992148161,
-0.008219083771109581,
-0.0038840733468532562,
-0.02205384150147438,
-0.0116882948204875,
0.005369160324335098,
0.052765678614377975,
-0.025565139949321747,
0.024374665692448616,
-0.004695760551840067,
-0.003370004938915372,
-0.019853265956044197,
-0.0050384728237986565,
-0.007990608923137188,
-0.025348689407110214,
0.034391485154628754,
0.00022415342391468585,
-0.021067790687084198,
-0.0007042138022370636,
0.018085593357682228,
-0.007563721854239702,
-0.02493984065949917,
-0.007756121922284365,
0.02342469058930874,
-0.004809997975826263,
-0.0007339004660025239,
-0.041967231780290604,
-0.019504541531205177,
0.02300381474196911,
-0.0050504980608820915,
-0.0035804423969238997,
-0.01664259284734726,
0.009199121035635471,
0.07296767085790634,
0.025204390287399292,
-0.0038359733298420906,
-0.0030378142837435007,
0.013407869264483452,
0.007148859556764364,
-0.05675797536969185,
-0.01061807107180357,
-0.00349626736715436,
-0.027128389105200768,
-0.020707041025161743,
-0.004734841641038656,
-0.02374936453998089,
-0.0026304677594453096,
-0.020731091499328613,
-0.04240013286471367,
-0.018085593357682228,
0.008261171169579029,
0.021512717008590698,
0.013011044822633266,
-0.023532915860414505,
-0.027777738869190216,
-0.004725823178887367,
0.008261171169579029,
0.007822259329259396,
-0.03234723582863808,
0.01208512019366026,
0.0010957777267321944,
-0.020851342007517815,
-0.019877316430211067,
0.012373720295727253,
0.01699131727218628,
-0.012806619517505169,
-0.043698832392692566,
0.019612766802310944,
-0.015283768996596336,
-0.03131308779120445,
0.016402093693614006,
0.005639722570776939,
-0.031529538333415985,
0.0027762707322835922,
-0.038407836109399796,
0.005826110020279884,
0.029148587957024574,
0.01835014298558235,
-0.010287383571267128,
0.0027071270160377026,
-0.00023486318241339177,
0.05507447570562363,
0.05435297638177872,
-0.02195764146745205,
0.0404280349612236,
-0.011874682269990444,
-0.02794608846306801,
0.012878770008683205,
0.001987130381166935,
0.00007402887422358617,
-0.013119270093739033,
0.030134636908769608,
0.013347744941711426,
0.0762384682893753,
-0.03210673853754997,
0.017712818458676338,
-0.006060597486793995,
0.0163660179823637,
0.041293833404779434,
0.011718357913196087,
-0.017592567950487137,
-0.04384313151240349,
0.024843640625476837,
0.013419894501566887,
0.0013452962739393115,
-0.02794608846306801,
-0.05012017861008644,
0.0008890980971045792,
-0.003264786209911108,
-0.00924120843410492,
-0.006721972022205591,
-0.0027928052004426718,
-0.03256368637084961,
0.002588380128145218,
-0.01937226764857769,
-0.014069244265556335,
-0.016257792711257935,
-0.006908359471708536,
-0.0018202835926786065,
-0.0006707692518830299,
-0.017171692103147507,
-0.016931192949414253,
-0.03872048482298851,
0.02813848853111267,
-0.0006008739583194256,
0.01827799342572689,
-0.04393933340907097,
0.0249157901853323,
0.00001760299528541509,
0.021885491907596588,
0.009716195985674858,
0.018518492579460144,
0.010840533301234245,
-0.017207767814397812,
0.006210910156369209,
-0.02322026528418064,
-0.011183245107531548,
0.0006038802093826234,
-0.0009311855537816882,
-0.008874446153640747,
0.04769112914800644,
0.02377341501414776,
0.02570943906903267,
-0.0007410403341054916,
0.016798917204141617,
-0.0013603275874629617,
0.006746022030711174,
0.035161085426807404,
0.0249157901853323,
-0.03638763353228569,
0.046584829688072205,
-0.014983143657445908,
-0.0034090860281139612,
0.0013580728555098176,
-0.0094396211206913,
-0.025348689407110214,
-0.03790278360247612,
-0.0118085453286767,
0.025348689407110214,
-0.039081234484910965,
-0.008700083941221237,
-0.011495895683765411,
0.008621921762824059,
0.025204390287399292,
-0.01696726866066456,
-0.04579118266701698,
0.004752879496663809,
-0.009024758823215961,
0.013023070059716702,
0.028234688565135002,
-0.0022576928604394197,
0.024747440591454506,
-0.017700793221592903,
0.012999019585549831,
0.008784258738160133,
-0.003679648507386446,
-0.0023118052631616592,
-0.003264786209911108,
-0.003538354765623808,
0.012710419483482838,
0.0174602922052145,
-0.011814557947218418,
-0.00628305971622467,
-0.029870087280869484,
0.01580084301531315,
-0.01548819337040186,
0.002068299101665616,
-0.011742407456040382,
0.027585338801145554,
-0.008303259499371052,
0.008459583856165409,
-0.008104846812784672,
0.016654618084430695,
0.006198884919285774,
-0.007665934506803751,
-0.0005771997384727001,
-0.010636107996106148,
0.0030047455802559853,
0.03121688775718212,
-0.013023070059716702,
0.01972099207341671,
0.014045193791389465,
0.013047119602560997,
-0.016498293727636337,
-0.0028363957535475492,
0.012361695058643818,
0.009373483248054981,
-0.009493733756244183,
-0.003595473477616906,
0.021043742075562477,
0.03508893400430679,
-0.012986994348466396,
-0.016558418050408363,
-0.01639006845653057,
0.02379746548831463,
-0.025637289509177208,
0.026406889781355858,
-0.011459819972515106,
0.01436986867338419,
0.030519437044858932,
-0.10226055979728699,
-0.01654639281332493,
0.0224025659263134,
0.01827799342572689,
-0.014790743589401245,
0.014610368758440018,
-0.0038780609611421824,
-0.0015083852922543883,
-0.0189994927495718,
-0.016305893659591675,
-0.006667859852313995,
-0.021103866398334503,
0.01587299257516861,
-0.012421820312738419,
-0.0037578109186142683,
-0.05084167793393135,
-0.007142846938222647,
-0.04718608036637306,
0.0008936074445955455,
0.030086537823081017,
-0.009626008570194244,
0.0029912174213677645,
-0.008303259499371052,
0.06594507396221161,
-0.00624698493629694,
0.03927363455295563,
-0.01939631626009941,
-0.0016564431134611368,
-0.05829717591404915,
-0.024651240557432175,
-0.004548454191535711,
-0.008453571237623692,
-0.016534367576241493,
0.03282823786139488,
-0.058874376118183136,
-0.030591586604714394,
0.03564208373427391,
0.0019074648153036833,
-0.00774409668520093,
0.008615909144282341,
0.0015211618738248944,
-0.005723897833377123,
-0.0015437087276950479,
0.006517547182738781,
0.005384191405028105,
-0.008609896525740623,
-0.03653193637728691,
-0.01815774291753769,
-0.012999019585549831,
-0.0035894610919058323,
0.03876858577132225,
-0.01785711757838726,
-0.017195742577314377,
0.025276539847254753,
0.013263569213449955,
-0.029340988025069237,
0.02128424122929573,
0.007034622132778168,
0.009151021018624306,
0.014935043640434742,
-0.02794608846306801,
0.03956223279237747,
0.042833033949136734,
0.004232798237353563,
-0.011081033386290073,
-0.012199357151985168,
-0.024230364710092545,
0.01329964492470026,
-0.033742137253284454,
0.02049059234559536,
-0.02436264045536518,
0.0048310416750609875,
-0.027633437886834145,
0.041245732456445694,
-0.007202972192317247,
0.014225569553673267,
-0.008002634160220623,
0.005714878905564547,
-0.00261393329128623,
0.04114953428506851,
-0.005829116329550743,
-0.02650308981537819,
0.013864818960428238,
0.00896463356912136,
-0.010816482827067375,
-0.01825394295156002,
-0.0010521870572119951,
0.023352541029453278,
-0.0013114759931340814,
0.006842222064733505,
0.005621685180813074,
-0.026262588798999786,
-0.025949940085411072,
-0.009175071492791176,
-0.01715966872870922,
-0.003117480082437396,
-0.012662319466471672,
0.014129369519650936,
0.0022471710108220577,
0.0013640853576362133,
0.020009592175483704,
-0.04309758171439171,
-0.01368444412946701,
-0.004927241709083319,
-0.008988684043288231,
0.010948757641017437,
0.04759493097662926,
-0.013696469366550446,
-0.007732071913778782,
-0.04836453124880791,
0.029220737516880035,
-0.009644046425819397,
0.036099035292863846,
-0.025204390287399292,
0.006081641186028719,
0.02079121582210064,
0.06142367422580719,
-0.03778253495693207,
-0.004259854555130005,
-0.010978820733726025,
0.05536307767033577,
0.01741219311952591,
-0.008772233501076698,
0.004779935348778963,
-0.0009747761650942266,
-0.014886943623423576,
-0.017568517476320267,
0.017724841833114624,
-0.003532342379912734,
0.011586083099246025,
0.011357608251273632,
-0.014478093944489956,
-0.005787028931081295,
-0.001524919643998146,
-0.022919639945030212,
0.04393933340907097,
0.013131294399499893,
0.04538233205676079,
0.006222934927791357,
0.03790278360247612,
0.00022095927852205932,
-0.016161592677235603,
-0.013492044061422348,
0.001685002469457686,
0.009138996712863445,
-0.005720891524106264,
-0.02645498886704445,
0.0024846645537763834,
0.010533895343542099,
-0.007846308872103691,
-0.013323694467544556,
0.03037513792514801,
0.04773923009634018,
0.04675317928195,
0.03713318333029747,
0.007966559380292892,
0.021993715316057205,
-0.028306838124990463,
-0.014850868843495846,
0.0027131394017487764,
-0.04341023042798042,
0.051947977393865585,
-0.024891739711165428,
-0.014995168894529343,
0.02377341501414776,
-0.024049989879131317,
0.007407397031784058,
-0.001089013647288084,
0.03773443400859833,
0.011099070310592651,
0.00013800560554955155,
-0.06200087442994118,
0.04708988219499588,
-0.004034386016428471,
-0.01548819337040186,
0.018734943121671677,
0.013155344873666763,
0.0049302480183541775,
0.009006720967590809,
0.004864110611379147,
-0.019901366904377937,
-0.011105082929134369,
0.0186748169362545,
-0.011020908132195473,
0.020430466160178185,
-0.03030298836529255,
0.008369396440684795,
-0.0089526092633605,
-0.008038708940148354,
0.009036784060299397,
-0.015476169064640999,
-0.001382874441333115,
0.014490119181573391,
0.04684938117861748,
0.006968484725803137,
-0.023905690759420395,
-0.013383819721639156,
0.011333557777106762,
-0.03922553360462189,
-0.018686842173337936,
-0.03330923616886139,
0.01741219311952591,
0.041390031576156616,
-0.015524269081652164,
-0.024747440591454506,
0.00871812179684639,
0.03174598515033722,
-0.03924958407878876,
-0.0249157901853323,
0.07075507193803787,
-0.0016519336495548487,
0.0513707771897316,
-0.00896463356912136,
0.0331408865749836,
0.01293889433145523,
-0.003823948325589299,
0.006782097276300192,
-0.006174834910780191,
-0.029918188229203224,
-0.004031379707157612,
-0.02002161741256714,
-0.04254443198442459,
-0.0005306029343046248,
-0.0295333880931139,
-0.005847153719514608,
0.001422707224264741,
0.03662813454866409,
0.01944441720843315,
-0.014814794063568115,
0.01706346869468689,
-0.04037993401288986,
0.012361695058643818,
0.025805639103055,
0.024110116064548492,
0.0017932273913174868,
0.008784258738160133,
-0.016859043389558792,
-0.03696483373641968,
0.011333557777106762,
-0.011111095547676086,
0.04797973111271858,
0.013383819721639156,
0.0024951864033937454,
-0.04160648211836815,
-0.025396790355443954,
0.00594335375353694,
0.061135075986385345,
-0.05064927786588669,
-0.003189629875123501,
-0.005546528846025467,
-0.0005245904321782291,
-0.00005617927308776416,
0.015295793302357197,
0.020971590653061867,
0.036748383194208145,
0.011441783048212528,
0.010515858419239521,
0.016859043389558792,
0.01780901849269867,
0.006493497174233198,
0.004497348330914974,
0.0002923576976172626,
-0.007750109303742647,
0.0004926490364596248,
0.011056982912123203,
-0.0038119235541671515,
-0.016053369268774986,
0.006180847529321909,
-0.005645735189318657,
0.02813848853111267,
0.02662333846092224,
0.0202140174806118,
0.0038149296306073666,
0.0011829588329419494,
0.0088924840092659,
-0.012277520261704922,
0.01895139180123806,
0.005116635467857122,
0.019456442445516586,
-0.002564330119639635,
-0.0022501773200929165,
0.014646444469690323,
-0.0220778901129961,
0.03097638674080372,
0.004449248313903809,
-0.025396790355443954,
-0.029076438397169113,
-0.0009266762062907219,
0.00886843353509903,
-0.0035714234691113234,
-0.022510791197419167,
0.007671946659684181,
0.0025838708970695734,
-0.020033642649650574,
-0.014213544316589832,
-0.02314811572432518,
0.001881911768577993,
-0.002370427129790187,
0.004879141692072153,
-0.007515621837228537,
-0.003844992257654667,
0.01666664332151413,
-0.03559398651123047,
-0.04249633103609085,
0.019167842343449593,
-0.019865291193127632,
-0.009313358925282955,
-0.029028337448835373,
0.05247708037495613,
-0.015379969030618668,
-0.03821543604135513,
-0.0006617504986934364,
0.0318421870470047,
0.012000945396721363,
0.025204390287399292,
0.024771489202976227,
-0.009343421086668968,
0.025973988696932793,
0.014237593859434128,
-0.0013986572157591581,
-0.013011044822633266,
0.006926397327333689,
0.02037034183740616,
-0.01601729355752468,
-0.03648383542895317,
-0.010004796087741852,
0.01934821717441082,
-0.00685424730181694,
-0.03246748819947243,
-0.017424218356609344,
-0.011952845379710197,
-0.019167842343449593,
0.01228353288024664,
-0.0012528541265055537,
-0.018121667206287384,
0.014910994097590446,
0.02249876596033573,
-0.0007703512674197555,
0.004485323093831539,
0.020382367074489594,
0.0004126076528336853,
0.009932645596563816,
0.004488329403102398,
-0.011093057692050934,
0.012999019585549831,
0.0055856104008853436,
-0.013852794654667377,
-0.015343893319368362,
-0.012626244686543941,
-0.01664259284734726,
0.046705082058906555,
-0.03722938522696495,
-0.03641168400645256,
0.042736832052469254,
0.013528119772672653,
-0.014189493842422962,
0.02893213741481304,
0.007545684464275837,
-0.024795539677143097,
0.015391993336379528,
0.00018732687749434263,
0.03239533677697182,
0.016113493591547012,
-0.017628643661737442,
0.021176015958189964,
0.004782941658049822,
-0.026262588798999786,
0.005125653930008411,
0.013924944214522839,
0.007142846938222647,
0.0021795304492115974,
0.027753688395023346,
-0.022294340655207634,
-0.012830669991672039,
-0.00924120843410492,
0.018662791699171066,
0.02724863961338997,
0.022667115554213524,
0.0027762707322835922,
0.03400668501853943,
0.011952845379710197,
-0.017580542713403702,
-0.02394176460802555,
-0.02741698920726776,
-0.019083667546510696,
-0.03044728748500347,
-0.021765241399407387,
-0.0073653096333146095,
0.003270798595622182,
-0.008676034398376942,
-0.013888869434595108,
-0.004422191996127367,
0.012091132812201977,
0.01554831862449646,
-0.020105792209506035,
0.01123735774308443,
0.02729673869907856,
0.013624319806694984,
-0.019937442615628242,
0.005360141396522522,
-0.03210673853754997,
0.003028795588761568,
0.02652713842689991,
0.0019931429997086525,
-0.007738084532320499,
0.04336213320493698,
0.010347507894039154,
0.013840769417583942,
0.0017932273913174868,
0.00906684622168541,
-0.0062169223092496395,
-0.02165701612830162,
-0.06291477382183075,
0.021897515282034874,
-0.024158215150237083,
0.0032587735913693905,
0.0022035804577171803,
-0.017592567950487137,
-0.019781116396188736,
0.0042297919280827045,
0.01599324308335781,
0.012481944635510445,
0.0006429614732041955,
0.0065355850383639336,
-0.01810964196920395,
-0.011153182946145535,
0.008585846051573753,
-0.012217395007610321,
-0.023352541029453278,
0.029773887246847153,
0.02242661640048027,
0.02967768721282482,
-0.008243134245276451,
-0.02575754001736641,
-0.043650731444358826,
0.0041215671226382256,
-0.016113493591547012,
0.010924708098173141,
-0.023508865386247635,
0.014959094114601612,
0.00808680895715952,
-0.0005745692760683596,
0.033020637929439545,
0.016329944133758545,
0.013804694637656212,
-0.028306838124990463,
0.019011517986655235,
-0.018939366564154625,
0.012409795075654984,
0.033044684678316116,
0.007714034523814917,
0.01517554372549057,
-0.014718594029545784,
-0.017123593017458916,
-0.007329234387725592,
0.007822259329259396,
-0.02736888825893402,
-0.03232318535447121,
-0.0015737712383270264,
-0.0054443166591227055,
-0.011501907370984554,
0.013492044061422348,
-0.00607863487675786,
0.026815738528966904,
-0.00875419657677412,
0.016907142475247383,
-0.0031685861758887768,
0.01517554372549057,
-0.02359304018318653,
-0.0024004897568374872,
0.009271271526813507,
0.027801789343357086,
0.02732078917324543,
-0.006740009877830744,
0.03658003360033035,
-0.012818644754588604,
0.052092280238866806,
0.006379259750247002,
0.01157405786216259,
-0.02126019075512886,
-0.026286639273166656,
0.007082722149789333,
0.011850632727146149,
-0.015933118760585785,
-0.000789891870226711,
0.027729637920856476,
0.011640194803476334,
-0.030687786638736725,
0.036724336445331573,
-0.00820705946534872,
0.024843640625476837,
0.0008620418375357985,
0.007341259624809027,
-0.025661339983344078,
-0.012602195143699646,
0.002445583464577794,
0.012445869855582714,
-0.0024185271468013525,
-0.014923019334673882,
0.00875419657677412,
0.00981239601969719,
-0.019564667716622353,
0.0015527275390923023,
-0.021428540349006653,
-0.019131766632199287,
0.009271271526813507,
-0.0342712365090847,
-0.04535828158259392,
0.0012250463478267193,
0.007653909269720316,
-0.021368416026234627,
-0.0003769084287341684,
-0.014730619266629219,
0.025348689407110214,
0.022138016298413277,
-0.03506488725543022,
-0.023340515792369843,
0.043602630496025085,
0.02431453950703144,
0.030158687382936478,
0.002873973920941353,
0.015307818539440632,
0.018795067444443703,
-0.020899441093206406,
-0.003535348456352949,
-0.013431919738650322,
0.01368444412946701,
0.01848241686820984,
-0.036050934344530106,
0.006673872470855713,
0.04939867928624153,
0.008050734177231789,
0.00916304625570774,
-0.005907278973609209,
-0.007503597065806389,
0.06479067355394363,
-0.017183717340230942,
-0.01589704304933548,
0.020851342007517815,
-0.023581014946103096,
-0.03422313556075096,
-0.007118796929717064,
0.024891739711165428,
0.006066610105335712,
0.01028137095272541,
0.0423760823905468,
0.03357378765940666,
-0.042736832052469254,
-0.014105319045484066,
0.04030778259038925,
0.029052387923002243,
-0.033381387591362,
0.009553859010338783,
-0.013167369179427624,
-0.036916736513376236,
-0.024110116064548492,
-0.006457422394305468,
0.012175307609140873,
-0.02955743856728077,
0.0018984461203217506,
0.024302514269948006,
-0.014285693876445293,
0.0273448396474123,
0.005546528846025467,
-0.016979293897747993,
0.012638269923627377,
-0.027008138597011566,
-0.016798917204141617,
-0.036916736513376236,
-0.00400432338938117,
-0.005799053702503443,
-0.01151393260806799,
0.0028228675946593285,
-0.007665934506803751,
-0.021572841331362724,
0.020238066092133522,
0.011706332676112652,
0.011441783048212528,
0.014923019334673882,
-0.013227494433522224,
-0.027489138767123222,
0.022113965824246407,
-0.021524740383028984,
0.0061868601478636265,
-0.017123593017458916,
-0.032251037657260895,
-0.040644481778144836,
0.029437188059091568,
0.01869886741042137,
0.013576219789683819,
-0.04915817826986313,
-0.01862671785056591,
0.01773686707019806,
-0.02394176460802555,
0.0054533351212739944,
0.02950933761894703,
0.003983279690146446,
0.024374665692448616,
-0.03583448380231857,
0.006782097276300192,
-0.024795539677143097,
0.02153676562011242,
-0.007708021905273199,
-0.03624333441257477,
0.00642134714871645,
-0.006908359471708536,
-0.014321769587695599,
-0.02081526629626751,
-0.023532915860414505,
0.007389359641820192,
-0.04006728529930115,
0.0004682232392951846,
0.004118560813367367,
-0.005357135087251663,
0.014297719113528728,
0.031409285962581635,
-0.05459347739815712,
-0.004118560813367367,
-0.023508865386247635,
-0.0013979056384414434,
0.053583379834890366,
0.04170268401503563,
-0.014297719113528728,
-0.00759979709982872,
0.029220737516880035,
0.008874446153640747,
0.006198884919285774,
0.01177247054874897,
0.04345833137631416,
-0.0256853885948658,
0.022691166028380394,
-0.011129133403301239,
0.0028363957535475492,
-0.02645498886704445,
-0.003929167054593563,
-0.00936145894229412,
-0.025517039000988007,
0.008886471390724182,
-0.032299138605594635,
0.026863839477300644,
0.00857983436435461,
-0.0017120586708188057,
-0.010720282793045044,
0.024122139438986778,
-0.03330923616886139,
0.028667587786912918,
0.0011032932670786977,
-0.02041844092309475,
-0.0048009795136749744,
0.0004640896513592452,
-0.019805166870355606,
0.019288092851638794,
0.003655598498880863,
-0.006036547478288412,
0.005170748103410006,
0.009944670833647251,
0.012037020176649094,
0.016462218016386032,
-0.02717648819088936,
-0.005615672562271357,
0.029846038669347763,
-0.0071668969467282295,
-0.011598107405006886,
0.02501199021935463,
0.007040634751319885,
0.0047017731703817844,
0.01566856913268566,
0.03410288691520691,
-0.011207295581698418,
-0.022113965824246407,
-0.025468939915299416,
-0.012217395007610321,
-0.013912918977439404,
-0.002132933586835861,
0.1350647509098053,
-0.030808037146925926,
0.006391284987330437,
0.010876608081161976,
-0.017604593187570572,
-0.0401875339448452,
0.01566856913268566,
0.014417968690395355,
0.026094239205121994,
-0.0034601923543959856,
0.036892686039209366,
0.023556964471936226,
0.035353485494852066,
0.021151965484023094,
0.014814794063568115,
-0.015885017812252045,
-0.0018172773998230696,
0.027513189241290092,
0.004169667139649391,
-0.002813848899677396,
-0.002220114693045616,
0.0038780609611421824,
-0.00953582115471363,
0.007251072209328413,
-0.021043742075562477,
0.014550244435667992,
-0.015091368928551674,
-0.012073094956576824,
-0.015776794403791428,
-0.02575754001736641,
0.015043268911540508,
-0.00070872314972803,
0.03119283728301525,
-0.018121667206287384,
-0.001621871255338192,
-0.03867238387465477,
-0.021596891805529594,
-0.01137564517557621,
0.008062759414315224,
0.015223643742501736,
-0.006872284691780806,
0.024699339643120766,
-0.0009695152402855456,
-0.0012723947875201702,
0.030759938061237335,
0.005242897663265467,
-0.032924436032772064,
0.00737132178619504,
0.004716804251074791,
-0.023412665352225304,
-0.011381657794117928,
0.0013926447136327624,
0.034535784274339676,
-0.012445869855582714,
-0.02799418941140175,
-0.03641168400645256,
0.03164978697896004,
-0.0055525414645671844,
-0.010335483588278294,
-0.028523288667201996,
-0.019492516294121742,
0.039778683334589005,
0.011117108166217804,
0.016305893659591675,
-0.00027563542244024575
] | 2025-01-09 | 1 | 39785827 | [
"CAR T cells",
"cancer cells",
"target cell encounter",
"solid tumors",
"Multiple tumor microenvironmental factors",
"improved tumor control",
"CAR T-cell efficacy",
"CAR T-cell activity",
"enhanced CAR T-cell proliferation",
"CAR T-cell dysfunction",
"TBK1 inhibition",
"CAR T-cell therapy",
"CAR T-cells",
"B7-H3.CAR T cells",
"TBK1",
"limited efficacy",
"co-inhibitory receptors",
"patient-derived organotypic tumor spheroids",
"B7-H3-directed CAR T cells",
"monotypic and organotypic tumor spheroids",
"ex vivo profiling",
"dynamic upregulation",
"CAR",
"appropriate model systems",
"3D microfluidic cultures",
"Novel therapeutic strategies",
"mechanistic studies",
"upregulation",
"Inhibition",
"B7-H3-expressing tumors"
] | [] | 0 | 10.1158/2326-6066.CIR-23-1011 | [
"Sun",
"Maggs",
"Panda",
"Wright",
"Cicerchia",
"Jenney",
"Perricone",
"Mills",
"Cattaneo",
"Ventin",
"Chen",
"Rasmussen",
"Miranda",
"Revach",
"Fang",
"Fu",
"Bowling",
"Sharova",
"Lawless",
"Sorger",
"Bardeesy",
"Wang",
"Flaherty",
"Boland",
"Mehta",
"Sade-Feldman",
"Ferrone",
"Jenkins"
] | [
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Broad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Broad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts.",
"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts.",
"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nDivision of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.\nCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Broad Institute of MIT and Harvard, Cambridge, Massachusetts.\nDivision of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.",
"Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nDepartment of Surgery, Cedars-Sinai Medical Center Los Angeles, Los Angeles, California.",
"Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.\nBroad Institute of MIT and Harvard, Cambridge, Massachusetts.\nLaboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts."
] | [
"39785827"
] | [] | 9.545181 | 5.80253 |
39781479 | 54 | Acute kidney injury following CAR-T cell therapy: a nephrologist's perspective. | Chimeric antigen receptor T (CAR-T) cell therapy, an emerging personalized immunotherapy for various haematologic malignancies, autoimmune diseases and other conditions, involves the modification of patients' T cells to express a chimeric antigen receptor that recognizes tumour or autoimmune cell antigens, allowing CAR-T cells to destroy cancerous and other target cells selectively. Despite remarkable clinical improvements in patients, multiple adverse effects have been associated with CAR-T cell therapy. Among the most recognized adverse effects are cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome and tumour lysis syndrome. Even though less recognized, the incidence of acute kidney injury (AKI) ranges from 5 to 33%. The wide range of reported AKI incidence rates might depend on patient population characteristics and comorbidities and specific CAR-T cell therapy features. Even though the exact pathophysiology remains unknown, several key mechanisms, including cytokine release syndrome, tumour lysis syndrome and other factors such as direct renal toxicity of CAR-T cell therapy, conditioning regimens or other medications (e.g. antibiotics), and infectious complications (e.g. sepsis) have been proposed. Risk factors for CAR-T-related AKI include lower baseline glomerular filtration rate, higher rates of allopurinol or rasburicase use, intravenous contrast material exposure, elevated baseline lactate dehydrogenase and grade 3 or higher cytokine release syndrome. Future prospective studies with larger patient populations are needed to gain insights into the pathophysiology of CAR-T-related AKI and, more importantly, to be able to prevent as well as to develop novel and more efficient treatment modalities. In this narrative review, we discuss the underlying pathophysiology, risk factors, potential interventions and future directions related to AKI following CAR-T cell therapy. | [
-0.01488800160586834,
0.0025384880136698484,
0.05674168840050697,
0.04902445897459984,
-0.025828173384070396,
-0.027768632397055626,
0.019003111869096756,
-0.008146580308675766,
-0.014609199948608875,
0.011899248696863651,
-0.005893864203244448,
-0.04048198089003563,
-0.04295773804187775,
-0.01206653006374836,
0.001983672846108675,
-0.055581871420145035,
0.033590007573366165,
0.006066721398383379,
-0.015925142914056778,
0.004993335343897343,
0.0073101758025586605,
0.01740836724638939,
-0.00009862604201771319,
0.001067809876985848,
-0.007990451529622078,
-0.028883839026093483,
0.02022983878850937,
-0.030645864084362984,
-0.028281627222895622,
-0.01871315762400627,
0.022605227306485176,
-0.030623558908700943,
-0.03251941129565239,
-0.029129182919859886,
0.0015696525806561112,
0.02251601219177246,
0.04025894030928612,
0.018400900065898895,
-0.02825932204723358,
-0.07034720480442047,
0.06325449049472809,
0.035329729318618774,
-0.0036272078286856413,
0.0778413861989975,
-0.07975953817367554,
-0.020107166841626167,
0.001293639070354402,
-0.0556710883975029,
0.028950750827789307,
0.010912291705608368,
-0.03247480094432831,
0.001204422558657825,
-0.04280161112546921,
0.04037046059966087,
-0.03055664710700512,
0.04088345542550087,
-0.035352032631635666,
0.005269348621368408,
0.01692882925271988,
-0.018467813730239868,
-0.0003120834589935839,
-0.0010064735542982817,
-0.004410640336573124,
-0.012724502012133598,
-0.044675156474113464,
-0.01856818236410618,
-0.03160494193434715,
-0.010538697242736816,
-0.0033846504520624876,
0.026631122455000877,
-0.001180724473670125,
-0.026809554547071457,
0.0030305725522339344,
-0.00239351112395525,
0.017597952857613564,
-0.004234995227307081,
-0.020687073469161987,
-0.0009172570426017046,
0.01052754558622837,
-0.014185422100126743,
0.05821375921368599,
-0.019560715183615685,
-0.01517795491963625,
-0.028370844200253487,
-0.007778562605381012,
-0.009328698739409447,
-0.028504667803645134,
-0.0478646457195282,
-0.04630335792899132,
0.009852846153080463,
-0.05393136665225029,
0.012200354598462582,
-0.04251165688037872,
0.050719574093818665,
-0.0007255809614434838,
0.02937452867627144,
0.0392998643219471,
-0.0335007905960083,
0.004934786818921566,
0.03524051234126091,
0.03017747774720192,
0.013393625617027283,
-0.003114213002845645,
0.009027593769133091,
0.04746317118406296,
0.004101170226931572,
-0.05763385072350502,
-0.03695793077349663,
0.027590198442339897,
-0.020977027714252472,
0.07610166817903519,
-0.005545362364500761,
-0.047820039093494415,
0.06744766235351562,
-0.040415070950984955,
-0.04269009083509445,
-0.025605132803320885,
0.0031114250887185335,
-0.03131498768925667,
0.022159146144986153,
-0.029463745653629303,
0.033032406121492386,
0.060845643281936646,
0.0023349628318101168,
-0.037069451063871384,
-0.03347848728299141,
0.0692766010761261,
-0.012836022302508354,
-0.041954055428504944,
-0.07712765783071518,
0.035530466586351395,
0.00911680981516838,
0.007326904218643904,
-0.024958312511444092,
-0.035352032631635666,
-0.00934542715549469,
-0.007081558927893639,
0.002946932101622224,
-0.028861533850431442,
-0.0405488945543766,
0.020798593759536743,
0.004519372712820768,
0.002369812922552228,
0.025471307337284088,
-0.025270570069551468,
-0.04492050036787987,
0.030801992863416672,
0.026140430942177773,
-0.016505049541592598,
0.04304695501923561,
-0.02335241623222828,
0.09555085748434067,
0.03187258914113045,
-0.0128471739590168,
0.01344938576221466,
-0.0256943479180336,
-0.0005405264673754573,
0.06205006688833237,
-0.020687073469161987,
-0.052860770374536514,
0.007527641020715237,
0.010683674365282059,
-0.008168884553015232,
-0.019382281228899956,
-0.005793495569378138,
-0.022259514778852463,
-0.014542287215590477,
0.025783564895391464,
-0.03796161711215973,
-0.027746327221393585,
-0.014854545705020428,
-0.04016972333192825,
-0.079090416431427,
-0.010232016444206238,
-0.048578377813100815,
-0.014731872826814651,
-0.004285179544240236,
0.020307904109358788,
-0.00034902465995401144,
-0.0011605113977566361,
-0.011218973435461521,
0.020586704835295677,
0.04032585397362709,
0.015244867652654648,
-0.05045192316174507,
-0.008347317576408386,
-0.004979395307600498,
0.03245249763131142,
-0.028593884781003,
-0.030489735305309296,
0.03834078460931778,
-0.01469841692596674,
0.002829835517331958,
-0.0013514903839677572,
-0.013181735761463642,
-0.02169075794517994,
-0.0036578760482370853,
0.010605609975755215,
-0.04688326641917229,
-0.004837206564843655,
0.06633245944976807,
-0.020441727712750435,
-0.0395452082157135,
-0.00009522814798401669,
-0.001527832355350256,
-0.01400698907673359,
-0.04732934758067131,
0.03834078460931778,
-0.00007405665382975712,
0.010092615149915218,
0.0375378392636776,
0.0020714954007416964,
-0.01662772335112095,
0.06539568305015564,
-0.0028716556262224913,
-0.016817308962345123,
-0.009088929742574692,
0.03490595147013664,
-0.017386063933372498,
-0.005550938192754984,
-0.0270772036164999,
-0.012490308843553066,
-0.01967223547399044,
0.03599885478615761,
-0.0584367997944355,
0.009930910542607307,
-0.013572058640420437,
0.013694730587303638,
0.015824774280190468,
-0.045455802232027054,
-0.054645098745822906,
0.004767505917698145,
0.0345044769346714,
-0.028147801756858826,
-0.024869095534086227,
-0.02113315649330616,
0.009490404278039932,
0.010482937097549438,
0.0682506114244461,
-0.021924952045083046,
0.03568659722805023,
0.00436324393376708,
-0.0005391324521042407,
-0.010795194655656815,
-0.023508545011281967,
-0.026051213964819908,
-0.005567666608840227,
-0.04460824280977249,
0.004948727320879698,
0.00882685650140047,
-0.009830541908740997,
-0.02937452867627144,
0.01104611624032259,
-0.0008475566282868385,
0.025984302163124084,
-0.02417766861617565,
0.05281616002321243,
-0.05125487223267555,
0.01967223547399044,
-0.030110564082860947,
0.046035706996917725,
-0.02417766861617565,
-0.034928254783153534,
-0.0491136759519577,
-0.036891017109155655,
0.027924761176109314,
-0.001835908042266965,
0.009930910542607307,
0.02551591582596302,
0.004460824653506279,
0.061425551772117615,
0.02169075794517994,
0.02319628745317459,
-0.03530742600560188,
-0.039812859147787094,
0.07338055968284607,
0.022616378962993622,
0.027500983327627182,
-0.025627436116337776,
0.0327424518764019,
0.005623426754027605,
0.0007262779981829226,
-0.0058213756419718266,
-0.019103480502963066,
0.0019000323954969645,
-0.025404395535588264,
-0.005877136252820492,
-0.003847460960969329,
-0.011386253871023655,
-0.03354540094733238,
0.017341455444693565,
-0.008068515919148922,
-0.023084767162799835,
0.011731968261301517,
-0.008046211674809456,
0.019003111869096756,
-0.01458689570426941,
-0.014174269512295723,
-0.05018427595496178,
0.0024771515745669603,
-0.04045967757701874,
0.012278418987989426,
-0.04572344943881035,
-0.021523477509617805,
0.025181353092193604,
0.018155556172132492,
-0.013783947564661503,
-0.02455683797597885,
0.01715186983346939,
0.038630738854408264,
0.04674943909049034,
0.0023210227955132723,
0.05629560351371765,
0.04224400594830513,
0.009819389320909977,
0.004290755372494459,
0.029731394723057747,
-0.059105925261974335,
0.04362686350941658,
-0.016661178320646286,
-0.012133442796766758,
-0.0385415218770504,
-0.024601446464657784,
0.00940676312893629,
0.0068362136371433735,
-0.011888097040355206,
0.039411384612321854,
0.005760039668530226,
0.022047623991966248,
-0.024110756814479828,
0.01285832654684782,
-0.05161174014210701,
0.014018140733242035,
-0.05098722130060196,
0.022147992625832558,
-0.014999521896243095,
-0.0038335209246724844,
-0.06329909712076187,
0.025382090359926224,
-0.016694635152816772,
0.019906429573893547,
0.03724788501858711,
-0.020319055765867233,
0.04320308566093445,
-0.024958312511444092,
-0.034727517515420914,
-0.005910592153668404,
-0.015044130384922028,
-0.01245685201138258,
0.027322549372911453,
-0.01439731102436781,
0.025560524314641953,
-0.0012099986197426915,
0.037470925599336624,
-0.04670483246445656,
0.038831476122140884,
-0.04737395420670509,
0.02919609658420086,
-0.01755334436893463,
-0.02843775600194931,
0.033010099083185196,
-0.003334466367959976,
-0.012869478203356266,
0.039076823741197586,
0.06579715758562088,
0.07181927561759949,
-0.04025894030928612,
0.029709091410040855,
-0.06847365200519562,
-0.03408069908618927,
-0.012044225819408894,
-0.011720816604793072,
0.011754272505640984,
-0.02317398227751255,
-0.03187258914113045,
0.06994573026895523,
0.006741420831531286,
0.02451222948729992,
0.01402929238975048,
0.010761738754808903,
0.004681077785789967,
0.013003302738070488,
0.028660796582698822,
-0.026207342743873596,
0.020441727712750435,
0.02609582245349884,
-0.017798690125346184,
-0.006334370467811823,
-0.07199770957231522,
0.048399943858385086,
-0.002380965044721961,
-0.007036950439214706,
-0.015657493844628334,
-0.004695017822086811,
0.005567666608840227,
0.0828821212053299,
-0.0362665019929409,
0.07467420399188995,
0.061024077236652374,
-0.0038251569494605064,
0.01700689271092415,
-0.014865697361528873,
-0.011302613653242588,
-0.02743406966328621,
0.006222850177437067,
-0.011051692068576813,
0.05045192316174507,
0.014709568582475185,
0.023040158674120903,
-0.013783947564661503,
0.042556263506412506,
-0.01647159457206726,
0.02121121995151043,
-0.0058213756419718266,
0.03956751152873039,
-0.046035706996917725,
-0.04706169664859772,
0.053083810955286026,
-0.015557125210762024,
0.04612492397427559,
0.03127037733793259,
-0.03914373368024826,
-0.007421696558594704,
-0.032028719782829285,
-0.003945041447877884,
0.017954818904399872,
0.005124371964484453,
0.006958886049687862,
0.0009590772679075599,
-0.049559760838747025,
-0.01557942945510149,
0.04581266641616821,
-0.034169916063547134,
-0.014140813611447811,
0.026430385187268257,
0.018657397478818893,
-0.022627532482147217,
-0.0008057364029809833,
-0.04309156537055969,
0.01780984178185463,
-0.0367794968187809,
0.0011451772879809141,
0.008129852823913097,
0.013315561227500439,
0.022159146144986153,
-0.016404680907726288,
0.003691332181915641,
0.020397119224071503,
-0.015490212477743626,
-0.01589168608188629,
-0.04052659124135971,
0.0013305803295224905,
0.008765519596636295,
-0.0019627627916634083,
-0.010031279176473618,
-0.009925334714353085,
-0.008620543405413628,
-0.05915053188800812,
0.00022792024537920952,
0.03849691525101662,
-0.0017034773482009768,
-0.04344842955470085,
0.012423396110534668,
-0.005988657008856535,
0.015400996431708336,
0.006312066689133644,
-0.006005384959280491,
-0.01644928939640522,
-0.02805858477950096,
-0.0332554467022419,
-0.016293160617351532,
-0.0178879052400589,
-0.03557507321238518,
0.011073996312916279,
0.013493994250893593,
0.009356578812003136,
-0.017542192712426186,
0.015445604920387268,
0.03254171460866928,
0.03167185187339783,
-0.014910305850207806,
-0.012222658842802048,
-0.02883923053741455,
0.005149464122951031,
0.01818901114165783,
0.03354540094733238,
0.009417915716767311,
0.018735462799668312,
-0.043939121067523956,
0.024110756814479828,
-0.02591739036142826,
-0.008207917213439941,
0.03200641646981239,
-0.008520174771547318,
-0.022382186725735664,
0.01569095067679882,
-0.017475279048085213,
-0.004156930837780237,
0.0014915881911292672,
0.0035491434391587973,
-0.005088127683848143,
0.010549849830567837,
-0.0019627627916634083,
0.03660106286406517,
0.008291557431221008,
0.047418564558029175,
0.022449098527431488,
0.04456363618373871,
0.021902648732066154,
0.015222563408315182,
-0.04014742001891136,
-0.03432604297995567,
0.05723237618803978,
-0.0005753766745328903,
-0.04266778379678726,
-0.020887810736894608,
-0.04516584798693657,
-0.02937452867627144,
-0.015389843843877316,
-0.002413027221336961,
-0.009072201326489449,
-0.0055871824733912945,
-0.0019669446628540754,
-0.018780071288347244,
0.02667573094367981,
-0.016036663204431534,
-0.027880152687430382,
0.02249370701611042,
-0.007878931239247322,
-0.03234097734093666,
0.04652639850974083,
0.018021730706095695,
-0.009953214786946774,
0.03640032559633255,
-0.03479443117976189,
-0.020196381956338882,
0.007254415657371283,
-0.0020087650045752525,
-0.03153802827000618,
-0.0007938873604871333,
0.00871533527970314,
-0.012401091866195202,
0.02417766861617565,
-0.01861278899013996,
-0.004221055191010237,
0.007388240657746792,
-0.009891877882182598,
-0.051121048629283905,
0.013505145907402039,
-0.022248361259698868,
0.022348729893565178,
-0.02961987443268299,
0.011508926749229431,
0.013505145907402039,
0.031426507979631424,
-0.011313766241073608,
-0.011999617330729961,
-0.027144117280840874,
-0.030735081061720848,
-0.019047720357775688,
-0.0031699733808636665,
-0.004876238759607077,
-0.014085053466260433,
-0.04947054386138916,
-0.05999808758497238,
0.016560811549425125,
0.02435610070824623,
-0.03196180611848831,
-0.012601829133927822,
0.02247140370309353,
-0.012601829133927822,
-0.008971832692623138,
0.014252333901822567,
-0.005208012647926807,
0.016382377594709396,
0.00396734569221735,
0.00039520117570646107,
0.021724214777350426,
0.0009737143409438431,
0.0109569001942873,
-0.036132678389549255,
-0.00006255609332583845,
-0.022025320678949356,
0.06075643002986908,
-0.016493897885084152,
0.019560715183615685,
-0.02357545681297779,
-0.001651899074204266,
-0.00521358847618103,
0.0010029885452240705,
0.053663719445466995,
-0.007449576631188393,
0.026385776698589325,
0.014453071169555187,
-0.024110756814479828,
0.039411384612321854,
0.04266778379678726,
-0.01081749889999628,
-0.0058213756419718266,
0.03414761275053024,
-0.007393816486001015,
-0.030668167397379875,
-0.039790552109479904,
-0.03762705251574516,
-0.015612885355949402,
0.03098042495548725,
0.020687073469161987,
-0.0024799394886940718,
-0.003702484304085374,
0.026631122455000877,
0.03876456245779991,
0.01353860180824995,
-0.03548585996031761,
0.03287627547979355,
0.012769109569489956,
0.015311779454350471,
-0.009094505570828915,
-0.01343823317438364,
0.0007193079218268394,
-0.014932610094547272,
-0.004193175118416548,
-0.0003882311284542084,
-0.0003023254103027284,
-0.006579716224223375,
0.02231527492403984,
-0.028460059314966202,
-0.013795099221169949,
0.008737639524042606,
0.02511444129049778,
0.0019390645902603865,
0.014743024483323097,
0.013705883175134659,
-0.009105658158659935,
0.039076823741197586,
0.006401283200830221,
-0.002279202453792095,
0.025828173384070396,
-0.034259133040905,
-0.02435610070824623,
0.018144402652978897,
-0.03735940530896187,
-0.006746997125446796,
-0.01546790823340416,
-0.034259133040905,
0.016014359891414642,
-0.01596975140273571,
-0.029686786234378815,
0.0014372218865901232,
0.013092519715428352,
-0.008865888230502605,
0.006027689203619957,
-0.03838539496064186,
-0.01743067055940628,
-0.018902743235230446,
0.0039060094859451056,
-0.02803628146648407,
0.0036299959756433964,
-0.019058872014284134,
0.07998257875442505,
0.051923997700214386,
-0.010332384146749973,
0.007410544436424971,
-0.003066816832870245,
-0.009691140614449978,
0.01439731102436781,
0.0017355395248159766,
0.038273874670267105,
-0.020965874195098877,
0.009239482693374157,
0.028906142339110374,
0.0828821212053299,
0.03524051234126091,
-0.034727517515420914,
-0.0051801325753331184,
0.017363758757710457,
0.01344938576221466,
0.029686786234378815,
-0.00014035914500709623,
-0.04621414095163345,
0.011012660339474678,
-0.01866855099797249,
0.006044417154043913,
-0.022081080824136734,
-0.049381326884031296,
-0.0009061049786396325,
-0.010181832127273083,
0.02975369803607464,
0.013114823959767818,
0.016482746228575706,
-0.018501268699765205,
-0.0019613688345998526,
-0.003234097734093666,
-0.05549265444278717,
-0.021768823266029358,
0.014408462680876255,
0.036333415657281876,
-0.02395462803542614,
-0.03352309390902519,
-0.009367731399834156,
-0.006412435322999954,
0.014809937216341496,
0.04050428420305252,
0.031627245247364044,
-0.01596975140273571,
0.03234097734093666,
-0.0015612886054441333,
0.02015177346765995,
-0.027344854548573494,
0.014230029657483101,
-0.020921265706419945,
0.005063035525381565,
-0.009378883056342602,
0.017341455444693565,
-0.02315167896449566,
-0.012211507186293602,
0.0007674011867493391,
-0.013070215471088886,
0.01934882625937462,
0.007622433826327324,
0.012534916400909424,
-0.01647159457206726,
0.031002730131149292,
-0.020698225125670433,
0.013070215471088886,
0.012189202941954136,
0.019683387130498886,
-0.034169916063547134,
0.02687646634876728,
0.009189298376441002,
-0.014285789802670479,
0.022884029895067215,
-0.03791700676083565,
-0.02375389076769352,
-0.021568085998296738,
-0.035753507167100906,
0.013661274686455727,
-0.026028910651803017,
-0.009417915716767311,
-0.03932216763496399,
0.006657780613750219,
0.029307616874575615,
-0.027947064489126205,
-0.00871533527970314,
0.05000584200024605,
0.00021554842533078045,
0.004335363861173391,
0.02999904379248619,
0.0034236826468259096,
0.009456947445869446,
-0.031203467398881912,
0.01596975140273571,
0.006518379785120487,
-0.0187689196318388,
-0.0031309411861002445,
0.02131158858537674,
-0.03196180611848831,
-0.0016086847754195333,
-0.007990451529622078,
-0.01828937977552414,
-0.005383657291531563,
0.0012093016412109137,
-0.0020240989979356527,
-0.0038028527051210403,
0.016337769106030464,
0.021300436928868294,
-0.029307616874575615,
0.030288998037576675,
0.016203945502638817,
0.003741516498848796,
0.0235531534999609,
-0.015679797157645226,
-0.014575744047760963,
0.012769109569489956,
0.008347317576408386,
-0.017586801201105118,
0.00915584247559309,
-0.05254851281642914,
0.00652395561337471,
0.008865888230502605,
-0.013661274686455727,
-0.0219138003885746,
-0.005765615496784449,
-0.0022624742705374956,
0.0345044769346714,
-0.008603814989328384,
-0.005910592153668404,
-0.008269253186881542,
-0.0013800675515085459,
-0.019281914457678795,
0.016360074281692505,
-0.004346515983343124,
0.020464032888412476,
-0.01167620811611414,
-0.006852941587567329,
-0.03445987030863762,
0.027813240885734558,
0.00832501333206892,
-0.05709855258464813,
0.0027852272614836693,
0.008994136936962605,
-0.01226726733148098,
0.01808864250779152,
0.008258101530373096,
-0.037783183157444,
0.01745297573506832,
0.005815799813717604,
-0.030690472573041916,
0.025159049779176712,
0.008888192474842072,
0.0037164243403822184,
-0.012088834308087826,
-0.01062791422009468,
-0.02133389189839363,
-0.01177657674998045,
-0.047017090022563934,
0.015389843843877316,
0.049738191068172455,
-0.012021921575069427,
-0.011062844656407833,
-0.018824679777026176,
0.05941818282008171,
-0.002767105121165514,
0.0045416769571602345,
-0.005024003330618143,
-0.01813325099647045,
-0.04826612025499344,
-0.0007883112994022667,
0.006696812808513641,
0.013382473029196262,
-0.012534916400909424,
0.02333011105656624,
-0.008207917213439941,
-0.00465319724753499,
0.02183573506772518,
-0.0024032690562307835,
-0.018724311143159866,
-0.009613076224923134,
0.010449481196701527,
0.020664768293499947,
0.024802183732390404,
0.014553439803421497,
-0.010795194655656815,
-0.002205320168286562,
-0.023218590766191483,
0.009166994132101536,
0.002828441560268402,
-0.024244580417871475,
0.005684763193130493,
0.01690652407705784,
-0.019984493032097816,
-0.006596444174647331,
0.007594553753733635,
0.014899153262376785,
-0.013460537418723106,
0.009456947445869446,
0.0017912997864186764,
0.019058872014284134,
-0.015702102333307266,
0.03921064734458923,
0.033768441528081894,
-0.014642655849456787,
-0.017285695299506187,
-0.01811094768345356,
-0.05223625525832176,
0.010008974932134151,
-0.04732934758067131,
0.01016510371118784,
0.00239351112395525,
0.004770294297486544,
-0.05937357246875763,
0.01487684901803732,
-0.02115545980632305,
0.0005046307342126966,
-0.014163117855787277,
-0.0070592546835541725,
-0.012579524889588356,
0.024289188906550407,
-0.01556827686727047,
-0.02513674646615982,
-0.017241086810827255,
0.0006841092254035175,
-0.02295094169676304,
0.019817212596535683,
0.00488739088177681,
0.04052659124135971,
-0.015400996431708336,
-0.00613363366574049,
-0.00452773692086339,
-0.009819389320909977,
0.004432944115251303,
-0.009490404278039932,
-0.007984875701367855,
-0.0032117934897542,
-0.025939693674445152,
0.008085244335234165,
0.0018094219267368317,
-0.02937452867627144,
0.02231527492403984,
-0.0619608499109745,
0.019058872014284134,
-0.018478965386748314,
-0.0050379433669149876,
0.007365936413407326,
0.04866759479045868,
0.001975308870896697,
0.027166420593857765,
-0.013750491663813591,
0.03539664298295975,
-0.010131647810339928,
0.019661083817481995,
-0.01584707945585251,
0.021679606288671494,
-0.006457043346017599,
0.015434452332556248,
-0.02199186384677887,
0.016482746228575706,
-0.016304314136505127,
0.057366203516721725,
0.01818901114165783,
-0.01768716797232628,
-0.014910305850207806,
-0.019583018496632576,
0.008999713696539402,
-0.005160616245120764,
0.007633585948497057,
0.013527450151741505,
0.037091754376888275,
0.02249370701611042,
-0.013505145907402039,
0.01987297274172306,
0.01274680532515049,
-0.015345236286520958,
0.02567204460501671,
0.032787058502435684,
-0.004611377138644457,
0.030846601352095604,
0.021679606288671494,
-0.008782248012721539,
0.00488739088177681,
0.01226726733148098,
-0.03372383117675781,
0.034259133040905,
-0.019783755764365196,
-0.04032585397362709,
0.04016972333192825,
0.016583114862442017,
-0.007338056340813637,
-0.03851921856403351,
0.0008412835886701941,
0.055180396884679794,
0.05134408921003342,
0.0003652299928944558,
-0.008341741748154163,
0.0014985582092776895,
-0.0027336489874869585,
-0.042132485657930374,
0.008347317576408386,
-0.025359787046909332,
0.0483553372323513,
-0.02511444129049778,
0.01439731102436781,
0.02471296675503254,
-0.03361231088638306,
-0.007304599974304438,
0.004798174370080233,
0.0327424518764019,
0.002491091610863805,
0.018200162798166275,
-0.04594649001955986,
0.03579811751842499,
-0.005029579624533653,
0.0038335209246724844,
-0.018267076462507248,
0.0049989111721515656,
-0.021869191899895668,
0.014910305850207806,
0.024400709196925163,
-0.04929210990667343,
-0.005294440779834986,
0.024802183732390404,
0.005389233585447073,
0.03811774402856827,
-0.022783661261200905,
-0.02277250774204731,
-0.0345044769346714,
0.014151965267956257,
-0.028660796582698822,
-0.03267553821206093,
-0.03816235437989235,
0.004714533686637878,
0.05625099688768387,
-0.002775469096377492,
-0.04594649001955986,
-0.0010420207399874926,
0.010549849830567837,
-0.031225770711898804,
-0.029909826815128326,
-0.008414230309426785,
0.0428239144384861,
0.04746317118406296,
-0.013371321372687817,
0.010583305731415749,
0.031448811292648315,
-0.0008113124640658498,
-0.02211453765630722,
0.02919609658420086,
-0.0025928542017936707,
-0.016237400472164154,
0.03742631524801254,
-0.022437946870923042,
0.035329729318618774,
0.025382090359926224,
0.012624133378267288,
0.002532911952584982,
-0.007611281704157591,
-0.04773082211613655,
0.000034087843232555315,
-0.05040731653571129,
-0.0443405956029892,
0.005458933766931295,
-0.015557125210762024,
0.006858517415821552,
-0.00701464619487524,
0.02040827088057995,
0.020865505561232567,
-0.015835925936698914,
-0.0038251569494605064,
-0.0070592546835541725,
0.029530657455325127,
0.015980903059244156,
0.008252524770796299,
0.013906620442867279,
0.01557942945510149,
-0.0266980342566967,
0.0023405388928949833,
0.022805964574217796,
-0.025828173384070396,
0.03227406367659569,
0.035931941121816635,
-0.004683865699917078,
-0.04416216164827347,
-0.0584367997944355,
-0.013293256983160973,
0.055581871420145035,
-0.0010963870445266366,
-0.0015348023734986782,
-0.009819389320909977,
-0.012813718058168888,
-0.01702919788658619,
0.049158286303281784,
0.022906333208084106,
0.007259991951286793,
-0.02101048268377781,
0.01947149820625782,
0.022683292627334595,
0.017163021489977837,
0.0057823434472084045,
-0.009903030470013618,
0.0256943479180336,
-0.032407891005277634,
-0.0039032213389873505,
0.022839421406388283,
0.007159623317420483,
0.004201538860797882,
-0.004681077785789967,
0.02173536643385887,
0.030422821640968323,
0.007081558927893639,
0.003331678221002221,
-0.018300531432032585,
-0.0013807645300403237,
-0.013371321372687817,
-0.012724502012133598,
0.013181735761463642,
0.007427272852510214,
-0.0002911733463406563,
-0.02101048268377781,
-0.009640957228839397,
-0.0033567703794687986,
-0.023642368614673615,
-0.005988657008856535,
0.019382281228899956,
-0.017196478322148323,
-0.017843298614025116,
-0.03336696699261665,
-0.009300818666815758,
0.013616666197776794,
-0.039634425193071365,
0.03160494193434715,
-0.0028312294743955135,
-0.0158693827688694,
0.015300627797842026,
-0.026408080011606216,
0.003958981484174728,
0.013360168784856796,
0.02279481291770935,
-0.014508831314742565,
-0.021958408877253532,
0.017386063933372498,
0.002955296076834202,
-0.021701911464333534,
-0.0027211029082536697,
-0.017876753583550453,
-0.025761261582374573,
-0.01896965503692627,
0.04616953432559967,
0.0047925980761647224,
-0.04269009083509445,
0.02151232585310936,
0.011620447970926762,
-0.02357545681297779,
0.02727794088423252,
-0.015512516722083092,
-0.022058777511119843,
0.0006074388511478901,
0.026028910651803017,
0.01672809198498726,
-0.0056763989850878716,
0.007678193971514702,
0.013761643320322037,
-0.018902743235230446,
-0.01226726733148098,
-0.04010281339287758,
-0.012434547767043114,
-0.004432944115251303,
-0.01879122294485569,
-0.005327897146344185,
-0.002680676756426692,
-0.00226108031347394,
0.008168884553015232,
0.020876659080386162,
0.0072321114130318165,
-0.002638856414705515,
0.0028521395288407803,
-0.031002730131149292,
-0.00744400080293417,
-0.016438137739896774,
-0.009356578812003136,
-0.004039834253489971,
-0.0036467239260673523,
0.009579620324075222,
0.03075738437473774,
-0.027545589953660965,
-0.02529287524521351,
-0.020664768293499947,
-0.0158693827688694,
-0.01811094768345356,
0.04612492397427559,
-0.001929306541569531,
-0.03916603699326515,
0.023218590766191483,
-0.01977260410785675,
-0.009267362765967846,
0.024623751640319824,
0.013995836488902569,
-0.016560811549425125,
-0.004182022996246815,
-0.012077681720256805,
0.03430373966693878,
0.04284621775150299,
-0.012055378407239914,
-0.0012441518483683467,
0.009702293202280998,
-0.02801397815346718,
0.01026547234505415,
0.0034543508663773537,
-0.008810128085315228,
0.011743119917809963,
0.004198750946670771,
-0.01833398826420307,
-0.002191379899159074,
0.002988752443343401,
0.011297037824988365,
0.03644493594765663,
0.010873259976506233,
0.010806347243487835,
0.044519029557704926,
-0.00399801367893815,
-0.02961987443268299,
-0.004798174370080233,
-0.03686871379613876,
-0.03796161711215973,
0.015702102333307266,
-0.02317398227751255,
-0.0324971042573452,
-0.011079573072493076,
-0.028303930535912514,
0.0219138003885746,
-0.014653808437287807,
0.00593847269192338,
-0.00783432275056839,
-0.03214024007320404,
-0.0022262302227318287,
-0.009239482693374157,
-0.020441727712750435,
-0.024445317685604095,
0.024088451638817787,
-0.021378500387072563,
-0.024199971929192543,
0.004173658788204193,
-0.009390035644173622,
0.006741420831531286,
-0.013070215471088886,
-0.009417915716767311,
0.012579524889588356,
0.014609199948608875,
0.011062844656407833,
-0.017374910414218903,
-0.014274638146162033,
-0.04737395420670509,
-0.00734363216906786,
-0.038095440715551376,
0.013427081517875195,
0.015155650675296783,
-0.02043057605624199,
-0.03180567920207977,
-0.013951228000223637,
0.03798392042517662,
0.011531230993568897,
-0.007466305047273636,
0.016917675733566284,
-0.013404777273535728,
-0.008720912039279938,
0.010114919394254684,
0.006222850177437067,
-0.03158263862133026,
0.021657302975654602,
-0.01909232884645462,
0.0013068821281194687,
0.0162485521286726,
-0.00734920846298337,
-0.017720624804496765,
0.000627651927061379,
0.005238680634647608,
0.01046620961278677,
-0.017319150269031525,
-0.003024996491149068,
-0.022103384137153625,
0.008559206500649452,
0.07057024538516998,
0.0046699256636202335,
0.014620351605117321,
-0.021924952045083046,
0.014475375413894653,
-0.02297324500977993,
0.03486134111881256,
0.03519590571522713,
0.028147801756858826,
0.008241373114287853,
-0.017497584223747253,
-0.03856382891535759,
-0.016583114862442017,
-0.008748792111873627,
-0.010248743928968906,
-0.007588977459818125,
0.02533748187124729,
0.031203467398881912,
0.005709855351597071,
0.0020282811019569635,
-0.02141195721924305,
0.00773953041061759,
0.036489542573690414,
0.0006105753709562123,
-0.002419997239485383,
-0.036511849611997604,
-0.017843298614025116,
0.02645268850028515,
0.0008545267046429217,
0.026564208790659904,
0.013493994250893593,
-0.009819389320909977,
0.027121812105178833,
-0.013025606982409954,
0.032608628273010254,
0.017319150269031525,
0.0004279603308532387,
-0.015657493844628334,
-0.02625195123255253,
0.003800064790993929,
0.002817289438098669,
-0.025939693674445152,
0.040035899728536606,
0.009038745425641537,
-0.016683483496308327,
-0.020687073469161987,
0.021668454632163048,
-0.00021990470122545958,
-0.013003302738070488,
-0.018501268699765205,
-0.012501460500061512,
-0.013070215471088886,
-0.011531230993568897,
-0.004951515235006809,
-0.01642698608338833,
-0.009730173274874687,
-0.0056150625459849834,
-0.01033796090632677,
-0.018802374601364136,
-0.00996436644345522,
0.009200450032949448,
-0.010661370120942593,
0.0010824468918144703,
-0.000705367885529995,
-0.03229636698961258,
-0.06517264246940613,
0.021077394485473633,
0.01964993216097355,
-0.03200641646981239,
-0.02040827088057995,
-0.014932610094547272,
0.0010008974932134151,
0.04612492397427559,
-0.023107070475816727,
0.005966352764517069,
0.048756811767816544,
0.03595424443483353,
0.009607500396668911,
-0.01803288236260414,
0.010298928245902061,
0.007761834654957056,
0.03077968768775463,
0.002474363660439849,
-0.011553535237908363,
0.02533748187124729,
0.0387868694961071,
0.0011277521261945367,
0.03820696100592613,
0.017140718176960945,
-0.00026869497378356755,
0.004354879725724459,
-0.0015571065014228225,
-0.026140430942177773,
0.055626481771469116,
-0.008614967577159405,
-0.011308189481496811,
-0.03189489617943764,
-0.03276475518941879,
-0.03874225914478302,
0.019482649862766266,
0.027211029082536697,
-0.02319628745317459,
0.005534210242331028,
0.01576901413500309,
0.03336696699261665,
-0.0037972768768668175,
0.0036690281704068184,
0.024043843150138855,
0.014676112681627274,
0.01468726433813572,
-0.01314827986061573,
-0.03354540094733238,
-0.001913972431793809,
-0.009328698739409447,
0.007890082895755768,
-0.0040983823128044605,
-0.040013596415519714,
0.0023126585874706507,
-0.013293256983160973,
0.012713349424302578,
0.001329186256043613,
0.013014455325901508,
-0.00881570391356945,
-0.015858231112360954,
-0.008575934916734695,
-0.014609199948608875,
-0.022884029895067215,
-0.0047758701257407665,
-0.0053251092322170734,
-0.00642916327342391,
-0.01992873288691044,
-0.022683292627334595,
0.015601733699440956,
0.005760039668530226,
-0.011090724729001522,
0.015601733699440956,
-0.0069811902940273285,
-0.012434547767043114,
-0.008397501893341541,
-0.013070215471088886,
-0.0020366450771689415,
0.0016309889033436775,
-0.03972364217042923,
-0.025382090359926224,
-0.04964897409081459,
-0.011179940775036812,
0.012445700354874134,
0.010499665513634682,
-0.032028719782829285,
0.00012859721027780324,
-0.01977260410785675,
-0.007772986777126789,
0.024802183732390404,
0.023240895941853523,
0.013326712884008884,
-0.002650008536875248,
-0.02317398227751255,
-0.008391926065087318,
0.003878129180520773,
0.011023811995983124,
0.026140430942177773,
-0.030467430129647255,
-0.029842915013432503,
-0.007416120730340481,
-0.027902456000447273,
-0.03521820902824402,
-0.028883839026093483,
0.010594458319246769,
-0.02995443530380726,
-0.006512803491204977,
-0.011397406458854675,
0.0003753365599550307,
0.001617048867046833,
0.006479347590357065,
-0.02395462803542614,
-0.01115763746201992,
-0.005350201390683651,
-0.00671911658719182,
0.015557125210762024,
0.060265738517045975,
-0.04442981258034706,
0.0025663680862635374,
0.01692882925271988,
0.019984493032097816,
-0.017664864659309387,
-0.00008215932757593691,
0.00681948522105813,
-0.025783564895391464,
-0.010789618827402592,
0.04315847530961037,
0.00041262625018134713,
-0.058882880955934525,
-0.011899248696863651,
-0.03272014856338501,
-0.02337471954524517,
0.016594266518950462,
-0.038876086473464966,
0.0027991672977805138,
0.003808428766205907,
0.007661466021090746,
-0.002120285527780652,
0.014932610094547272,
-0.040035899728536606,
0.01527832355350256,
-0.007784138433635235,
-0.034169916063547134,
0.01891389489173889,
0.0069700381718575954,
-0.009172569960355759,
0.026987988501787186,
0.025404395535588264,
0.02315167896449566,
0.005916168447583914,
0.0033679225016385317,
-0.011731968261301517,
0.006858517415821552,
-0.006880821660161018,
0.0013033971190452576,
0.0249360091984272,
-0.00901644118130207,
-0.01439731102436781,
0.01518910750746727,
-0.010577729903161526,
0.005506330169737339,
0.025025224313139915,
0.012769109569489956,
-0.002104951534420252,
-0.0015808047028258443,
-0.010443905368447304,
0.004037045873701572,
-0.030088260769844055,
-0.039076823741197586,
0.1526494175195694,
-0.0019111845176666975,
0.004616953432559967,
-0.00046559853944927454,
0.021423108875751495,
-0.020207535475492477,
0.014776481315493584,
0.010772891342639923,
0.015267171896994114,
0.0005053277709521353,
-0.0019167604623362422,
0.0038837052416056395,
0.03209563344717026,
0.004315847530961037,
0.021077394485473633,
-0.019281914457678795,
-0.02151232585310936,
0.025203658267855644,
-0.005063035525381565,
-0.022003017365932465,
0.023798497393727303,
0.015055282041430473,
-0.009417915716767311,
0.01657196320593357,
-0.028370844200253487,
-0.01705150119960308,
-0.007455152925103903,
0.008765519596636295,
0.012836022302508354,
0.015032978728413582,
0.0008949529146775603,
0.02901766262948513,
0.009696717374026775,
-0.02035251073539257,
0.002829835517331958,
-0.019939884543418884,
0.0004683865699917078,
0.0003502444305922836,
-0.011731968261301517,
0.02241564355790615,
0.0013514903839677572,
0.017899058759212494,
-0.0010294746607542038,
0.005640154704451561,
0.013471690006554127,
0.005765615496784449,
-0.03751553222537041,
0.010438329540193081,
0.00764473807066679,
-0.021668454632163048,
-0.006451467517763376,
-0.0025384880136698484,
0.013382473029196262,
-0.020720530301332474,
-0.035329729318618774,
-0.02587278187274933,
0.010271048173308372,
-0.012211507186293602,
-0.02357545681297779,
-0.018044034019112587,
-0.00997551903128624,
-0.005288864951580763,
0.02417766861617565,
-0.0014623140450567007,
0.007979299873113632
] | 2025-01-09 | 52 | 39781479 | [
"reported AKI incidence rates",
"cytokine release syndrome",
"other factors",
"tumour lysis syndrome",
"AKI",
"larger patient populations",
"specific CAR-T cell therapy",
"CAR-T cell therapy",
"higher rates",
"other medications",
"lower baseline glomerular filtration rate",
"other conditions",
"Risk factors",
"risk factors",
"patients T cells",
"CAR-T cells",
"intravenous contrast material exposure",
"immune effector cell-associated neurotoxicity syndrome",
"multiple adverse effects",
"elevated baseline lactate dehydrogenase",
"patient population characteristics",
"tumour or autoimmune cell antigens",
"patients",
"cancerous and other target cells",
"autoimmune diseases",
"Future prospective studies",
"acute kidney injury",
"various haematologic malignancies",
"future directions",
"infectious complications"
] | [
"acute kidney injury",
"autoimmunity",
"chimeric antigen receptor T-cell therapy",
"nephrotoxicity",
"onconephrology"
] | 0 | 10.1093/ckj/sfae359
10.1016/j.currproblcancer.2021.100826
10.1016/S0140-6736(23)01126-1
10.1038/s41591-022-02017-5
10.1056/NEJMoa2308917
10.1056/NEJMoa1707447
10.1177/2040620719841581
10.1056/NEJMoa2024850
10.1016/S0140-6736(21)00933-8
10.1007/s44228-023-00037-7
10.1016/j.bulcan.2022.08.014
10.1016/j.ekir.2021.02.013
10.1016/j.bbmt.2018.12.758
10.1097/CCM.0000000000002053
10.1016/j.clim.2024.110311
10.1016/j.mayocpiqo.2021.01.004
10.1016/j.bcp.2024.116203
10.1093/ndt/gfz169
10.1016/j.biopha.2022.113677
10.1681/ASN.2021030383
10.1073/pnas.1716578115
10.1016/j.jacc.2019.10.049
10.1152/ajpheart.2000.279.6.H2815
10.1111/jcmm.17029
10.1038/nrclinonc.2017.148
10.1681/ASN.2014111090
10.1016/j.jtct.2023.12.653
10.3389/fimmu.2023.1125357
10.1126/scitranslmed.aac5415
10.1681/ASN.2018050488
10.1016/j.xkme.2021.06.011
10.1200/JCO.1991.9.9.1562
10.1182/blood.V74.1.19.19
10.1016/j.urology.2016.07.030
10.1016/j.bbmt.2020.02.012
10.1016/j.mayocp.2022.05.018
10.1093/ckj/sfae123
10.1093/ckj/sfae027
10.1053/j.ajkd.2019.10.011
10.1056/NEJMc2107725
10.1093/rheumatology/kead330
10.1136/ard-2023-223952
10.1016/S0140-6736(23)00023-5
10.1016/j.xkme.2021.03.011
10.1111/ajt.16367
10.1016/j.clml.2022.07.007
10.1016/j.xkme.2024.100856
10.1186/s40164-022-00266-1
10.1053/j.ajkd.2020.08.017
10.1007/s00467-024-06331-7
10.1182/bloodadvances.2021006293
10.3389/fonc.2021.664421 | [
"Kanbay",
"Mizrak",
"Alper",
"Copur",
"Ortiz"
] | [
"Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.",
"Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.",
"Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.",
"Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.",
"Department of Medicine, Universidad Autonoma de Madrid and IIS-Fundacion Jimenez Diaz, Madrid, Spain."
] | [
"39781479",
"35012754",
"37748491",
"36109639",
"38381673",
"29226797",
"31019670",
"33626253",
"34175021",
"37010812",
"36220698",
"34013119",
"30592986",
"27632680",
"38996858",
"34195558",
"38615919",
"31504777",
"36942605",
"35046131",
"29588419",
"31856973",
"11087236",
"34734474",
"28925994",
"25858966",
"37215107",
"24055823",
"29959196",
"34939018",
"1714949",
"2473795",
"27566144",
"32088364",
"35787856",
"38915438",
"34562407",
"38500492",
"31973908",
"34347960",
"37432378",
"37147112",
"36930673",
"34401733",
"33089906",
"39100867",
"35227310",
"36161297",
"33098925",
"38507119",
"35446934",
"34113569"
] | [] | 5.973433 | 4.174767 |
39781381 | 55 | Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer. | Resistance to the currently available treatment paradigms is one of the main factors that contributes to poor outcomes in patients with advanced cervical cancer. Novel targeted therapy approaches might enhance the patient's treatment outcome and are urgently needed for this malignancy. While chimeric-antigen receptor (CAR)-based adoptive immunotherapy displays a promising treatment strategy for liquid cancers, their use against cervical cancer is largely unexplored. This study used alpharetroviral SIN vectors to equip natural killer (NK) cells with a third-generation CAR (including CD28 and 4-1BB co-stimulatory domains) targeting Mesothelin, which was identified to be highly expressed on primary human cervical cancer tissues and cervical cancer cell lines in this and other studies. Anti-Mesothelin CAR-NK cells demonstrated high cytotoxicity against cervical cancer cells in 2D and 3D culture models, which corresponded to increased degranulation of CAR-NK-92 cells upon exposure to Mesothelin | [
0.020946966484189034,
0.0069586532190442085,
0.045278582721948624,
0.07020192593336105,
-0.046178001910448074,
-0.009822588413953781,
-0.005819587968289852,
0.02047358825802803,
-0.01337292231619358,
0.006124325096607208,
-0.0075326235964894295,
-0.03221335634589195,
-0.03566901385784149,
0.041302211582660675,
0.021325668320059776,
-0.025870095938444138,
0.05339701101183891,
-0.015432115644216537,
0.030651209875941277,
0.052260905504226685,
0.05623728036880493,
0.027716267853975296,
0.010361055843532085,
0.004358034115284681,
-0.050414733588695526,
0.014201332814991474,
0.02133750356733799,
0.015834486111998558,
-0.028426334261894226,
-0.038769640028476715,
0.010751592926681042,
-0.017763501033186913,
-0.030272508040070534,
-0.023609716445207596,
-0.02828432247042656,
0.008432041853666306,
0.026272466406226158,
0.01652088388800621,
-0.03185832500457764,
-0.015219095163047314,
0.04553894326090813,
0.0073255212046206,
0.012935047969222069,
0.09093587100505829,
-0.05841481685638428,
0.005162776447832584,
-0.021562358364462852,
-0.06475807726383209,
0.014473524875938892,
-0.028355328366160393,
-0.02603577822446823,
0.0047012330032885075,
-0.013692451640963554,
0.041325878351926804,
-0.029160071164369583,
0.030035819858312607,
-0.03069854900240898,
-0.011503079906105995,
0.004707150161266327,
0.026485485956072807,
0.006112490314990282,
-0.013148067519068718,
0.029562441632151604,
-0.026627499610185623,
-0.052876297384500504,
-0.015372943133115768,
-0.025420386344194412,
-0.0205327607691288,
0.012088884599506855,
0.007307769265025854,
0.03595304116606712,
-0.003624298609793186,
0.04156256839632988,
-0.0011797461193054914,
-0.0003690867160912603,
0.0038402772042900324,
0.029254745692014694,
-0.007881740108132362,
-0.031597964465618134,
0.008319614455103874,
0.04248565435409546,
-0.015148088335990906,
0.0317399799823761,
-0.014662876725196838,
-0.005816629156470299,
-0.028828706592321396,
-0.015704307705163956,
-0.010798930190503597,
-0.068450428545475,
0.009165776893496513,
-0.04002409055829048,
0.013798962347209454,
-0.061775799840688705,
0.038367267698049545,
-0.037041809409856796,
0.073231540620327,
0.003751518903300166,
-0.060166314244270325,
0.047882162034511566,
0.004174600355327129,
0.0051331901922822,
0.02365705370903015,
0.00045969418715685606,
0.019278310239315033,
0.029231077060103416,
0.006721964571624994,
-0.004890583921223879,
-0.006597702857106924,
0.030248839408159256,
0.01630786433815956,
0.086580790579319,
-0.03474592790007591,
0.015621466562151909,
0.013704286888241768,
-0.010556324385106564,
-0.040994513779878616,
-0.04198860749602318,
-0.023017993196845055,
-0.004784074146300554,
0.05524318665266037,
-0.026083115488290787,
0.012982385233044624,
0.031976670026779175,
-0.03140861541032791,
-0.010662834160029888,
-0.011627341620624065,
0.04478153586387634,
-0.013100730255246162,
-0.030154164880514145,
-0.0007418717141263187,
0.0014534177025780082,
-0.004452709574252367,
-0.006082904525101185,
-0.03356248512864113,
-0.0626278817653656,
0.014816723763942719,
-0.029562441632151604,
0.0016420291503891349,
-0.010929109528660774,
0.015739811584353447,
0.016686566174030304,
-0.006591785233467817,
-0.02563340589404106,
0.005204197019338608,
-0.019929204136133194,
-0.035550668835639954,
0.0057870433665812016,
0.019408488646149635,
0.04184659570455551,
0.045964982360601425,
-0.04591764509677887,
0.052260905504226685,
0.05983494967222214,
0.01630786433815956,
-0.0581781268119812,
-0.0001659595873206854,
-0.0008542989380657673,
0.012248650193214417,
-0.04248565435409546,
-0.07971681654453278,
-0.007840319536626339,
-0.015858154743909836,
-0.01723095029592514,
0.0007980853551998734,
0.037041809409856796,
-0.005358044523745775,
-0.009875843301415443,
0.022769471630454063,
-0.047077421098947525,
-0.001215989119373262,
0.030154164880514145,
-0.032497383654117584,
-0.03933769091963768,
0.0012477942509576678,
-0.04418981447815895,
-0.002264816779643297,
0.040402792394161224,
0.013159901835024357,
-0.012094802223145962,
0.01679307594895363,
0.0035118714440613985,
0.05836747959256172,
0.035313982516527176,
0.02553873136639595,
0.0015399570111185312,
0.049704667180776596,
-0.006290006916970015,
0.03190566226840019,
-0.06111307069659233,
-0.004733777604997158,
-0.031479623168706894,
0.007757478393614292,
0.04570462554693222,
0.035432327538728714,
0.010366973467171192,
0.004263358656316996,
0.03983473777770996,
0.04998869076371193,
-0.02068660780787468,
-0.030438190326094627,
0.027597924694418907,
-0.020946966484189034,
-0.026414480060338974,
-0.012722027488052845,
0.004772239830344915,
-0.04908927530050278,
-0.02097063511610031,
0.02676951326429844,
-0.0033668994437903166,
0.009041515178978443,
0.046272676438093185,
0.03408319875597954,
-0.004218979272991419,
0.037751875817775726,
-0.024757657200098038,
-0.020177727565169334,
-0.013952809385955334,
0.011828526854515076,
0.04520757868885994,
-0.00046413211384788156,
-0.009207197465002537,
-0.005097686778753996,
-0.029964812099933624,
0.0189942829310894,
-0.016402538865804672,
-0.0062130833975970745,
0.02043808437883854,
-0.02849734202027321,
-0.0034112785942852497,
-0.03297076001763344,
-0.013727955520153046,
0.013053392060101032,
0.025680743157863617,
-0.014509028755128384,
-0.038083240389823914,
-0.030745886266231537,
0.02544405497610569,
0.009361045435070992,
0.028805037960410118,
0.022165914997458458,
0.02118365466594696,
-0.005180527921766043,
0.026414480060338974,
0.018367057666182518,
-0.03384651243686676,
-0.0019201386021450162,
0.0004970466834492981,
-0.04641469195485115,
-0.011603672988712788,
-0.010609579272568226,
-0.043740104883909225,
0.03493528068065643,
-0.005423134192824364,
-0.024154100567102432,
0.005284079350531101,
0.023633385077118874,
-0.009645071811974049,
-0.021964728832244873,
0.0171954482793808,
-0.020331574603915215,
0.003254472278058529,
0.005402423907071352,
-0.02300615981221199,
-0.030769554898142815,
-0.06712497025728226,
-0.005597691982984543,
-0.02093513123691082,
0.006574033759534359,
0.058036115020513535,
-0.03753885626792908,
0.014426187612116337,
0.016047505661845207,
0.05685266852378845,
-0.00955631397664547,
-0.06011897698044777,
0.0065681166015565395,
-0.027124546468257904,
0.02504168450832367,
0.0180948656052351,
0.03626073896884918,
-0.014047485776245594,
0.007213093806058168,
0.006597702857106924,
-0.016603725031018257,
-0.025278372690081596,
0.0065681166015565395,
0.006032607983797789,
0.013088895007967949,
0.011094791814684868,
-0.052970971912145615,
-0.00248523335903883,
0.002949735149741173,
-0.044047802686691284,
-0.01031371857970953,
-0.039077334105968475,
0.017254618927836418,
0.0005613964749500155,
-0.019432157278060913,
-0.03313644230365753,
0.0421779602766037,
-0.028544679284095764,
0.014698379673063755,
0.0057870433665812016,
-0.0146510424092412,
-0.019384820014238358,
-0.002031086478382349,
-0.011059287935495377,
-0.0021597861777991056,
0.020023880526423454,
0.06201248615980148,
0.021609695628285408,
-0.009077019058167934,
-0.008633227087557316,
0.037041809409856796,
0.013869968242943287,
0.022378934547305107,
0.04998869076371193,
-0.045041896402835846,
0.007633216679096222,
-0.03936136141419411,
-0.035527002066373825,
-0.01072792336344719,
-0.017088936641812325,
0.02195289358496666,
0.021195489913225174,
-0.03387017920613289,
0.028568347916007042,
-0.00382844265550375,
0.03547966480255127,
-0.06494743376970291,
-0.0009733830229379237,
-0.03297076001763344,
0.06579951196908951,
-0.053160324692726135,
0.019337482750415802,
0.007432030979543924,
-0.024876002222299576,
-0.04284068942070007,
0.008130263537168503,
-0.020580098032951355,
0.04629634693264961,
0.021881887689232826,
-0.010988281108438969,
0.058036115020513535,
-0.03181098774075508,
-0.02337302826344967,
-0.04229630529880524,
0.014520863071084023,
0.04478153586387634,
0.05495915934443474,
-0.007970497943460941,
0.030225170776247978,
0.013775292783975601,
0.0350772924721241,
0.022272424772381783,
0.037254828959703445,
-0.03112458810210228,
-0.029136402532458305,
0.03895898908376694,
0.003627257188782096,
0.00790540874004364,
0.016390705481171608,
-0.02911273203790188,
0.03820158541202545,
0.06830841302871704,
0.03342046961188316,
-0.022639291360974312,
0.024852333590388298,
-0.037160154432058334,
-0.023586047813296318,
-0.013798962347209454,
-0.0013727955520153046,
-0.009059267118573189,
0.018580077216029167,
-0.025373049080371857,
0.025207366794347763,
0.013822630979120731,
0.02050909213721752,
0.01480488944798708,
-0.021609695628285408,
0.040189772844314575,
-0.022094907239079475,
-0.0324263758957386,
-0.03862762451171875,
-0.022958822548389435,
0.0016479463083669543,
-0.00003917848152923398,
-0.04807151108980179,
-0.08473461866378784,
0.0335388146340847,
0.013112564571201801,
0.0023254682309925556,
0.017858175560832024,
0.0065444475039839745,
-0.01556229405105114,
0.05969293788075447,
-0.010739758610725403,
0.08653345704078674,
0.045467935502529144,
0.021006138995289803,
-0.0031627551652491093,
-0.001148680690675974,
-0.008609558455646038,
0.004875791259109974,
0.006952736061066389,
-0.07072263956069946,
-0.0019512040307745337,
0.0021272413432598114,
0.04762180522084236,
-0.023171842098236084,
-0.047101087868213654,
0.015550459735095501,
0.036024048924446106,
0.021041641011834145,
0.0049112942069768906,
-0.05169285088777542,
-0.002900918247178197,
0.04177558794617653,
0.01692325621843338,
0.014970571734011173,
0.04764547199010849,
-0.044355496764183044,
0.009461638517677784,
-0.02062743715941906,
0.016225023195147514,
0.0008764885133132339,
0.021420344710350037,
-0.013751624152064323,
-0.005585857667028904,
-0.07233212143182755,
-0.007769312709569931,
0.07138536870479584,
0.013656948693096638,
-0.02241443656384945,
0.0010813723783940077,
0.0670776292681694,
-0.021266495808959007,
0.01128414273262024,
-0.048308201134204865,
0.04835553839802742,
-0.006792970933020115,
-0.010195373557507992,
-0.03436722606420517,
-0.030059488490223885,
0.02939675934612751,
0.0037426429335027933,
-0.01005336083471775,
0.00957406498491764,
-0.05046207085251808,
-0.02868669293820858,
-0.0024985470809042454,
-0.05282896012067795,
0.007189424708485603,
0.00968057569116354,
-0.02016589231789112,
-0.041396886110305786,
0.043740104883909225,
-0.055101171135902405,
0.01663922891020775,
0.014059320092201233,
0.04255666211247444,
-0.018627414479851723,
-0.012177643366158009,
-0.031242933124303818,
-0.005736746825277805,
0.034911610186100006,
0.022059403359889984,
-0.025089021772146225,
0.023668888956308365,
-0.035029955208301544,
-0.0033136443234980106,
0.0007045192760415375,
-0.04856855794787407,
0.014958737418055534,
0.007011908106505871,
0.05543253570795059,
0.02381090261042118,
0.0071420869790017605,
-0.004920170176774263,
0.04468686133623123,
-0.012295987457036972,
0.014284173958003521,
-0.018225044012069702,
-0.02596477046608925,
0.019254641607403755,
0.04317205399274826,
-0.020698443055152893,
-0.022532781586050987,
0.02778727561235428,
0.03001215122640133,
0.01763332262635231,
0.003007428254932165,
0.030438190326094627,
-0.010905439965426922,
-0.005751539953052998,
-0.021349336951971054,
0.021479517221450806,
-0.027029870077967644,
-0.027124546468257904,
-0.008142097853124142,
-0.0024245816748589277,
0.028355328366160393,
0.02114815264940262,
0.012213146314024925,
0.06286456435918808,
0.017254618927836418,
0.02068660780787468,
0.05794144049286842,
-0.008378786966204643,
0.011041536927223206,
-0.04693540558218956,
-0.004328447859734297,
0.02501801587641239,
-0.012426166795194149,
-0.01534927450120449,
-0.005145024508237839,
-0.0608290433883667,
0.003100624307990074,
-0.015538625419139862,
-0.017656991258263588,
-0.02185821905732155,
-0.00012084077025065199,
-0.028331659734249115,
0.008485296741127968,
0.003565126331523061,
-0.03678145259618759,
-0.007508954964578152,
-0.023112669587135315,
-0.03569268435239792,
-0.028828706592321396,
0.004227855242788792,
-0.0302015021443367,
0.018165871500968933,
0.021420344710350037,
-0.021822715178132057,
0.0002450099855195731,
-0.02949143573641777,
0.03384651243686676,
-0.03578735888004303,
-0.03495894744992256,
0.03526664525270462,
-0.027905618771910667,
-0.0020828621927648783,
-0.0076272995211184025,
0.012710193172097206,
0.01505341287702322,
0.01970434933900833,
0.006627288646996021,
-0.008958674035966396,
0.015148088335990906,
0.013290081173181534,
-0.01663922891020775,
-0.005979353096336126,
-0.009183528833091259,
0.010372890159487724,
-0.008639144711196423,
-0.002822514856234193,
-0.0361897312104702,
0.010319635272026062,
0.017006095498800278,
-0.017313791438937187,
0.0004404632200021297,
0.0008579972200095654,
-0.032805077731609344,
0.022639291360974312,
-0.0038757803849875927,
-0.015006075613200665,
0.01408298872411251,
-0.025799088180065155,
0.02534938044846058,
-0.018875937908887863,
-0.011763437651097775,
0.041112858802080154,
-0.03791755810379982,
0.03831993043422699,
-0.0003337683156132698,
-0.004958631936460733,
0.030083157122135162,
-0.01895877905189991,
0.016757573932409286,
-0.03557433933019638,
0.006124325096607208,
0.0026805016677826643,
0.02291148342192173,
-0.03152696043252945,
0.009893595241010189,
-0.0231008343398571,
-0.022059403359889984,
-0.0350772924721241,
-0.00340832001529634,
0.03325478732585907,
0.013159901835024357,
0.04163357615470886,
-0.026130452752113342,
-0.033799171447753906,
0.00277517712675035,
0.013905472122132778,
-0.006863977760076523,
0.011071122251451015,
-0.035337649285793304,
0.00694681890308857,
0.0022248756140470505,
-0.024260610342025757,
-0.058935534209012985,
-0.00424560671672225,
0.013242742978036404,
0.010361055843532085,
-0.03699447214603424,
0.022627457976341248,
0.009674658067524433,
0.029420427978038788,
0.04807151108980179,
0.00873973686248064,
-0.029041726142168045,
0.036047715693712234,
-0.0094971414655447,
0.0257517509162426,
-0.024106763303279877,
0.00643202057108283,
-0.0515035018324852,
-0.02482866495847702,
-0.023858239874243736,
-0.0213019996881485,
0.013053392060101032,
-0.013041557744145393,
-0.03822525590658188,
-0.024165935814380646,
-0.003189382841810584,
0.0023639302235096693,
-0.029657118022441864,
-0.002511860802769661,
-0.02402392216026783,
0.00841428991407156,
0.015526791103184223,
-0.016698401421308517,
-0.03351514786481857,
0.018177706748247147,
-0.026840519160032272,
0.013017889112234116,
0.03143228217959404,
-0.026319803670048714,
0.04094717651605606,
-0.013775292783975601,
-0.017278289422392845,
0.021870052441954613,
0.008142097853124142,
-0.021230993792414665,
-0.004863956477493048,
-0.012852206826210022,
-0.0016449877293780446,
-0.01855640858411789,
-0.024852333590388298,
-0.019645176827907562,
-0.014355180785059929,
0.0006871374207548797,
-0.0050917696207761765,
0.008591806516051292,
0.01530193630605936,
0.04518390819430351,
0.049278624355793,
-0.027810944244265556,
0.012887709774076939,
0.0032781411428004503,
-0.011763437651097775,
-0.022426271811127663,
-0.003609505482017994,
0.003860987490043044,
0.0104379802942276,
0.010869937017560005,
0.012343325652182102,
0.07408361881971359,
0.02114815264940262,
0.0036479674745351076,
-0.025491392239928246,
-0.006331427488476038,
0.02016589231789112,
0.00878707505762577,
-0.00075666478369385,
-0.029680786654353142,
0.0021050518844276667,
0.004532592371106148,
0.001569543150253594,
-0.01661556027829647,
-0.022556450217962265,
-0.009023764170706272,
0.012112554162740707,
0.020047549158334732,
0.030390853062272072,
0.006585868075489998,
-0.009290038608014584,
0.014828559011220932,
-0.042603999376297,
-0.03223702684044838,
0.007899491116404533,
0.023538710549473763,
0.0366157703101635,
-0.0006989718531258404,
-0.007633216679096222,
0.008733820170164108,
-0.021077144891023636,
0.028663024306297302,
0.020213231444358826,
0.018793096765875816,
0.006248586345463991,
0.03630807623267174,
-0.029160071164369583,
0.0005111000500619411,
-0.02594110183417797,
0.03905366733670235,
0.010455731302499771,
-0.03600037842988968,
-0.011041536927223206,
-0.005553313065320253,
-0.03081689216196537,
-0.029680786654353142,
0.013219074346125126,
-0.01258001383394003,
0.027290228754281998,
0.0023787233512848616,
0.01663922891020775,
0.010301883332431316,
0.00111391709651798,
0.011130294762551785,
0.010982364416122437,
0.01152083184570074,
0.02918373979628086,
-0.03398852422833443,
0.068450428545475,
-0.00031916017178446054,
-0.023704390972852707,
-0.009562230668962002,
-0.0246393121778965,
-0.023148173466324806,
-0.010520820505917072,
-0.017254618927836418,
0.01383446529507637,
-0.03763353452086449,
-0.015952831134200096,
-0.011633258312940598,
0.005272245034575462,
0.04426082223653793,
-0.05869884416460991,
-0.045964982360601425,
-0.00239351624622941,
-0.023290187120437622,
0.0293020848184824,
0.012177643366158009,
0.015207260847091675,
0.014520863071084023,
-0.029870137572288513,
-0.007804816123098135,
0.007846236228942871,
-0.021112648770213127,
0.003671636339277029,
-0.033207450062036514,
-0.04007142782211304,
-0.02229609340429306,
-0.015704307705163956,
-0.022828642278909683,
-0.03171630948781967,
-0.043550755828619,
0.005994146224111319,
-0.007609547581523657,
-0.011727934703230858,
-0.003878739196807146,
0.012260484509170055,
0.01575164496898651,
0.025278372690081596,
-0.01750314235687256,
0.042746011167764664,
0.0026982533745467663,
-0.02553873136639595,
0.004254482686519623,
-0.008775240741670132,
-0.0056361542083323,
0.026532823219895363,
-0.012651020660996437,
0.0077752298675477505,
0.0029245871119201183,
0.03607138618826866,
0.023609716445207596,
-0.012461669743061066,
0.004130220972001553,
0.014497194439172745,
0.007621381897479296,
-0.01312439888715744,
-0.023550543934106827,
0.013219074346125126,
-0.0017219115979969501,
-0.008668730035424232,
-0.03936136141419411,
0.021006138995289803,
-0.01155041716992855,
0.031668972223997116,
-0.0031805068720132113,
0.019491329789161682,
0.004650936461985111,
-0.0843559205532074,
-0.019384820014238358,
-0.008745654486119747,
-0.014367015101015568,
-0.009017846547067165,
0.014520863071084023,
-0.03820158541202545,
-0.02272213250398636,
0.004926087334752083,
-0.0014393642777577043,
0.00778114702552557,
-0.006136159412562847,
0.014840393327176571,
0.0001205634034704417,
0.009627320803701878,
0.009645071811974049,
-0.02482866495847702,
-0.03708914667367935,
-0.013763458468019962,
0.03190566226840019,
0.013704286888241768,
0.021728038787841797,
-0.0014497194206342101,
0.047195762395858765,
-0.010532655753195286,
-0.017219116911292076,
-0.01646171137690544,
-0.010633247904479504,
-0.019041620194911957,
-0.048095181584358215,
-0.01707710325717926,
-0.020946966484189034,
-0.01205929834395647,
0.04537326097488403,
-0.02603577822446823,
-0.022674795240163803,
0.020923297852277756,
-0.014059320092201233,
-0.015372943133115768,
0.02256828546524048,
0.004588805604726076,
0.006680544000118971,
0.013420259580016136,
0.012923212721943855,
-0.0006642082007601857,
-0.01813036948442459,
-0.020023880526423454,
0.04255666211247444,
0.009775251150131226,
-0.028639355674386024,
0.028355328366160393,
-0.042746011167764664,
-0.03760986402630806,
-0.028568347916007042,
-0.010656917467713356,
-0.005230824463069439,
-0.002430499065667391,
0.025893764570355415,
-0.006834391504526138,
0.020698443055152893,
-0.020177727565169334,
0.033799171447753906,
0.02646181732416153,
-0.007550375536084175,
-0.01805936172604561,
-0.021728038787841797,
-0.03813057765364647,
0.014864061959087849,
-0.010503069497644901,
-0.000010921435205091257,
0.0028151185251772404,
0.0028594976756721735,
-0.06745633482933044,
0.0321660190820694,
0.011952788569033146,
-0.01701793074607849,
-0.010798930190503597,
-0.010260462760925293,
0.022438107058405876,
0.04142055660486221,
-0.048521220684051514,
0.006988239474594593,
-0.02513635903596878,
-0.0025281331036239862,
0.006248586345463991,
-0.003934952896088362,
0.02766893059015274,
0.015514956787228584,
0.010420228354632854,
-0.027550585567951202,
0.0030799140222370625,
-0.03678145259618759,
-0.020485423505306244,
-0.0019615590572357178,
-0.005899470299482346,
0.004233772400766611,
-0.0027426325250416994,
-0.013396590948104858,
0.013952809385955334,
-0.008603640832006931,
0.048095181584358215,
-0.02991747483611107,
-0.01155041716992855,
0.00833736639469862,
-0.016532719135284424,
-0.017313791438937187,
0.04736144468188286,
0.009361045435070992,
0.029562441632151604,
0.0009393590153194964,
0.017183613032102585,
-0.024355286732316017,
0.021692536771297455,
-0.024378955364227295,
0.019029786810278893,
0.0302015021443367,
0.032284364104270935,
0.007822567597031593,
0.0036953052040189505,
-0.01828421652317047,
0.0541544184088707,
0.009964602068066597,
-0.012438001111149788,
-0.011047453619539738,
0.00433732382953167,
-0.0010954258032143116,
0.0037485603243112564,
-0.01575164496898651,
0.028118640184402466,
-0.011088874191045761,
0.008846246637403965,
0.014402518980205059,
0.038580287247896194,
-0.005068100523203611,
-0.020887793973088264,
0.03637908026576042,
0.00796458125114441,
0.02757425419986248,
-0.0039201597683131695,
0.020236900076270103,
0.039787400513887405,
-0.0033402720000594854,
-0.037254828959703445,
-0.01460370421409607,
0.039172012358903885,
0.011094791814684868,
-0.038864314556121826,
-0.008970508351922035,
0.02037891373038292,
0.00714800413697958,
-0.007171673234552145,
0.03254472091794014,
0.019313812255859375,
0.047077421098947525,
-0.008266359567642212,
0.04984667897224426,
0.055905915796756744,
-0.006254503969103098,
-0.011727934703230858,
0.017242785543203354,
-0.03992941603064537,
0.04518390819430351,
-0.04461585357785225,
-0.02504168450832367,
0.00231215450912714,
0.004000042099505663,
-0.010935026220977306,
0.006071069743484259,
0.033704496920108795,
0.018875937908887863,
-0.012100718915462494,
-0.06769302487373352,
0.04035545513033867,
0.011372900567948818,
-0.036852460354566574,
-0.004636143334209919,
0.0290890634059906,
0.007136169821023941,
0.019337482750415802,
0.012260484509170055,
-0.040402792394161224,
-0.015372943133115768,
-0.009852174669504166,
0.01667473278939724,
0.033704496920108795,
-0.03271040320396423,
-0.01581081748008728,
-0.022000232711434364,
0.013514935038983822,
-0.008449792861938477,
-0.007076997775584459,
-0.026272466406226158,
0.012651020660996437,
0.03723116219043732,
0.03183465451002121,
-0.037657201290130615,
-0.012402497231960297,
0.004757446702569723,
-0.02312450483441353,
-0.02797662653028965,
-0.0008905419381335378,
0.013301915489137173,
0.06376398354768753,
-0.013562273234128952,
-0.04236730933189392,
0.023171842098236084,
0.008775240741670132,
-0.04757446423172951,
-0.015680639073252678,
0.04331406578421593,
0.018603745847940445,
0.0559532530605793,
-0.020023880526423454,
0.013846299611032009,
0.009449804201722145,
0.03486427292227745,
-0.01077526155859232,
0.016970593482255936,
-0.004295903258025646,
-0.0033491477370262146,
-0.033396802842617035,
-0.013597776181995869,
-0.030130494385957718,
-0.003597671166062355,
-0.022994324564933777,
0.0019275351660326123,
0.06357463449239731,
0.035124629735946655,
0.000924565945751965,
0.001463772845454514,
-0.04085250198841095,
0.01797652058303356,
-0.012426166795194149,
-0.0016301947180181742,
-0.005076976493000984,
-0.012840371578931808,
-0.007597713265568018,
-0.019964708015322685,
0.01828421652317047,
-0.029657118022441864,
0.04468686133623123,
-0.008757488802075386,
0.01536110881716013,
-0.0395270437002182,
-0.012935047969222069,
0.01648538000881672,
0.040189772844314575,
-0.010538572445511818,
-0.023905577138066292,
-0.003798856632784009,
-0.020852290093898773,
0.006065152585506439,
0.024142267182469368,
0.021787211298942566,
0.023917412385344505,
0.007745643611997366,
-0.00846162810921669,
-0.01216580905020237,
0.01957417093217373,
-0.004005959257483482,
0.002877249149605632,
0.011071122251451015,
0.005082893650978804,
-0.010420228354632854,
-0.000719312287401408,
-0.012153973802924156,
-0.005645029712468386,
-0.03564534708857536,
0.02918373979628086,
0.021668868139386177,
0.03235537186264992,
0.005195321049541235,
-0.022130411118268967,
-0.01667473278939724,
0.0023683682084083557,
-0.019645176827907562,
0.017006095498800278,
-0.007662802468985319,
-0.00036760742659680545,
0.013503100723028183,
0.021964728832244873,
-0.004689398687332869,
0.0026627499610185623,
0.00873973686248064,
0.025704413652420044,
0.009077019058167934,
-0.02062743715941906,
-0.0001371131365885958,
0.02072211168706417,
-0.03493528068065643,
-0.022343430668115616,
0.003056245157495141,
-0.0016020878683775663,
-0.024000253528356552,
-0.028047632426023483,
-0.03902999684214592,
0.0022618582006543875,
-0.02979912981390953,
-0.009503059089183807,
-0.011745685711503029,
0.024473629891872406,
0.024994345381855965,
-0.022331595420837402,
-0.01627236045897007,
0.02185821905732155,
-0.02362154982984066,
-0.023586047813296318,
-0.049278624355793,
0.015514956787228584,
-0.022225085645914078,
-0.03233170136809349,
0.012153973802924156,
0.012970550917088985,
-0.0065444475039839745,
-0.010414310730993748,
-0.004603598732501268,
-0.0128758754581213,
0.03143228217959404,
0.0036627606023103,
-0.001940848887898028,
-0.00399116612970829,
0.011402486823499203,
-0.0373021699488163,
0.015266433358192444,
-0.029136402532458305,
0.009840340353548527,
0.011686514131724834,
-0.0014904002891853452,
-0.008609558455646038,
-0.007698305882513523,
0.018319720402359962,
0.009059267118573189,
0.00025462545454502106,
0.007899491116404533,
0.011751603335142136,
0.01840256154537201,
0.010923191905021667,
0.004929046146571636,
0.014887730590999126,
0.0009548917296342552,
-0.002392037073150277,
0.007621381897479296,
-0.0005258931196294725,
0.009278204292058945,
0.008035588078200817,
0.0246393121778965,
-0.017396632581949234,
0.029231077060103416,
0.004816618748009205,
-0.007686471566557884,
0.040592145174741745,
-0.020343409851193428,
-0.04489988088607788,
0.058320142328739166,
0.017716163769364357,
-0.0043136547319591045,
0.00012093322584405541,
0.004713067319244146,
0.023692557588219643,
0.026414480060338974,
-0.01824871264398098,
0.037657201290130615,
0.022165914997458458,
-0.007929077371954918,
-0.0002126501640304923,
-0.005816629156470299,
-0.025207366794347763,
0.006745633203536272,
-0.02106531150639057,
-0.0008224938646890223,
0.007923160679638386,
0.04104185104370117,
-0.036852460354566574,
-0.009130273945629597,
-0.0005817369092255831,
0.01757415011525154,
0.028521010652184486,
0.024142267182469368,
0.0033195617143064737,
0.0324263758957386,
0.008035588078200817,
-0.00631367601454258,
-0.03252105414867401,
-0.02158602699637413,
-0.014485360123217106,
-0.03214235231280327,
-0.006858060602098703,
-0.02081678807735443,
0.016591891646385193,
-0.0028491425327956676,
0.012077050283551216,
0.009710161946713924,
0.02074578031897545,
0.03176364675164223,
-0.009272286668419838,
-0.020343409851193428,
-0.000029239397917990573,
0.0019896659068763256,
0.0035503332037478685,
-0.0021257619373500347,
-0.03271040320396423,
-0.0016967634437605739,
0.00302961771376431,
0.013810796663165092,
0.00014053402992431074,
0.034414563328027725,
0.0014711694093421102,
0.007970497943460941,
-0.004659812431782484,
-0.024402623996138573,
-0.0019083041697740555,
0.017159944400191307,
-0.05931423604488373,
0.03495894744992256,
-0.009935015812516212,
-0.0020813827868551016,
0.024130431935191154,
0.004393537528812885,
-0.031787317246198654,
-0.026532823219895363,
-0.004704191815108061,
0.00391424261033535,
0.005991187412291765,
-0.013716121204197407,
-0.018378891050815582,
0.03171630948781967,
0.01707710325717926,
0.004254482686519623,
-0.037964895367622375,
0.03100624307990074,
0.016568221151828766,
0.009219031780958176,
0.01191728562116623,
-0.00804150477051735,
-0.015313770622015,
0.009165776893496513,
0.012733861804008484,
0.007917243055999279,
-0.03600037842988968,
0.025893764570355415,
-0.024757657200098038,
0.011869947426021099,
0.001859487034380436,
0.003591753775253892,
0.014710213989019394,
-0.014958737418055534,
-0.00898826029151678,
0.04045012965798378,
0.0213019996881485,
0.006100655999034643,
0.010290049016475677,
0.023302020505070686,
-0.025467723608016968,
-0.0111007085070014,
-0.03524297475814819,
0.009053349494934082,
-0.03429621830582619,
-0.0073846932500600815,
-0.0032130517065525055,
0.012006043456494808,
-0.04965732991695404,
-0.020307905972003937,
-0.0018372974591329694,
-0.0058965119533240795,
-0.014426187612116337,
0.007479368709027767,
-0.006473441142588854,
-0.006733798887580633,
-0.022520948201417923,
0.013905472122132778,
-0.009491223841905594,
0.0026346431113779545,
0.023089000955224037,
-0.025207366794347763,
0.003165713744238019,
-0.02208307385444641,
0.04601231962442398,
0.002991155721247196,
0.005195321049541235,
-0.0018935110419988632,
-0.02285231277346611,
0.019136296585202217,
0.002002979628741741,
0.01267469022423029,
0.010177621617913246,
0.026390811428427696,
-0.003707139752805233,
-0.026438148692250252,
0.04381111264228821,
0.009899512864649296,
0.0030355348717421293,
-0.023609716445207596,
-0.04078149423003197,
0.009029680863022804,
-0.009698326699435711,
-0.000003004839300047024,
0.004597681574523449,
-0.009153942577540874,
0.0025828673969954252,
0.00474857073277235,
-0.010372890159487724,
0.004686439875513315,
-0.004340282641351223,
-0.023491371423006058,
-0.01409482304006815,
-0.010136201046407223,
-0.031574297696352005,
-0.07436764985322952,
0.00802967045456171,
-0.004026669543236494,
-0.012769365683197975,
-0.01534927450120449,
-0.0072012594901025295,
0.01429600827395916,
0.03678145259618759,
-0.025988439098000526,
-0.005828463938087225,
0.0473141074180603,
0.009242701344192028,
0.005875801667571068,
0.023574212566018105,
0.0061184074729681015,
0.011035619303584099,
-0.026106784120202065,
-0.003970455843955278,
-0.03415420651435852,
-0.012532676570117474,
0.03398852422833443,
-0.017952851951122284,
0.008526717312633991,
0.03342046961188316,
-0.01932564750313759,
0.004961590748280287,
-0.006337345112115145,
-0.034722261130809784,
0.026083115488290787,
-0.028118640184402466,
-0.01459186989814043,
-0.0281896460801363,
-0.01924280636012554,
-0.028331659734249115,
0.0013432094128802419,
-0.000866133370436728,
0.01057407632470131,
-0.012047464028000832,
0.01707710325717926,
0.033302124589681625,
-0.02624879777431488,
-0.018816767260432243,
0.03363348916172981,
0.003810690948739648,
-0.012153973802924156,
0.02204756997525692,
0.00529591366648674,
-0.016875917091965675,
0.0012588889803737402,
-0.006195331458002329,
0.02970445528626442,
-0.030272508040070534,
0.01982269436120987,
0.016532719135284424,
0.011313728988170624,
0.03585836663842201,
0.04291169345378876,
0.008656895719468594,
-0.009130273945629597,
-0.003943828400224447,
0.0015355191426351666,
-0.023148173466324806,
0.003417195752263069,
-0.03711281716823578,
-0.004150931257754564,
-0.022899650037288666,
0.016958758234977722,
-0.024994345381855965,
0.053775716572999954,
-0.027100877836346626,
-0.002501505659893155,
-0.04913661256432533,
0.02047358825802803,
-0.011313728988170624,
-0.015219095163047314,
-0.017952851951122284,
0.0050207627937197685,
-0.03190566226840019,
-0.03768087178468704,
0.0032130517065525055,
0.013148067519068718,
0.014840393327176571,
-0.00873973686248064,
-0.04402413219213486,
0.003689388046041131,
0.02306533232331276,
0.007680554408580065,
0.010148036293685436,
0.0331127755343914,
-0.008745654486119747,
-0.002239668508991599,
-0.02337302826344967,
0.01140840444713831,
-0.009816671721637249,
0.029467767104506493,
-0.00872198585420847,
-0.014260505326092243,
0.02112448215484619,
0.0018639250192791224,
0.012473504059016705,
-0.03316011279821396,
-0.0014541572891175747,
-0.0030680797062814236,
-0.01646171137690544,
-0.005432009696960449,
-0.004221938084810972,
0.02003571391105652,
0.015242763794958591,
0.019905535504221916,
-0.04246198758482933,
0.007893574424088001,
0.0033787337597459555,
0.010751592926681042,
0.020520925521850586,
0.061491772532463074,
0.0013217595405876637,
-0.006775219459086657,
0.004227855242788792,
-0.011864030733704567,
0.010420228354632854,
-0.016781242564320564,
0.02294698730111122,
0.017609652131795883,
-0.004198268987238407,
0.016970593482255936,
-0.0021168862003833055,
-0.03770453855395317,
0.006284089758992195,
-0.03363348916172981,
-0.029964812099933624,
0.002909793984144926,
-0.03545599430799484,
0.0029408594127744436,
-0.016142182052135468,
0.005112479906529188,
0.003609505482017994,
0.02106531150639057,
-0.061160407960414886,
0.0162131879478693,
-0.0017470598686486483,
-0.03100624307990074,
0.007183507550507784,
-0.002656832803040743,
-0.018201375380158424,
0.016390705481171608,
0.016296029090881348,
0.023207345977425575,
0.014520863071084023,
0.004263358656316996,
0.0033195617143064737,
-0.002957131713628769,
-0.02501801587641239,
-0.0119350366294384,
-0.00042825896525755525,
-0.022213252261281013,
0.002927545690909028,
0.03342046961188316,
-0.014887730590999126,
-0.004177558701485395,
0.004026669543236494,
0.014958737418055534,
-0.018733926117420197,
0.003863946069031954,
-0.03060387261211872,
0.015337440185248852,
0.0030325762927532196,
-0.011603672988712788,
0.10092414170503616,
-0.03356248512864113,
-0.015159922651946545,
0.004053296986967325,
-0.002221916802227497,
-0.008136180229485035,
0.021290164440870285,
0.005745622795075178,
0.014615538530051708,
-0.03678145259618759,
0.024189604446291924,
0.011864030733704567,
0.03976373374462128,
0.008361035026609898,
0.03600037842988968,
-0.024449961259961128,
-0.00458584725856781,
0.046367350965738297,
0.004612474702298641,
-0.022520948201417923,
-0.009402466006577015,
-0.0016065258532762527,
-0.028142308816313744,
0.011793023906648159,
-0.035834696143865585,
0.007822567597031593,
-0.0032781411428004503,
-0.02979912981390953,
0.0030710382852703333,
-0.017124440521001816,
-0.018390726298093796,
0.009029680863022804,
0.02189372107386589,
-0.014485360123217106,
-0.021692536771297455,
-0.04047380015254021,
-0.007372858934104443,
-0.037136487662792206,
-0.014284173958003521,
0.0010133242467418313,
0.018852269276976585,
-0.024473629891872406,
-0.01581081748008728,
0.01658005639910698,
0.01920730248093605,
0.005485265050083399,
-0.0379885658621788,
0.00810659397393465,
0.022473609074950218,
-0.035432327538728714,
-0.006840308662503958,
0.002245585899800062,
-0.01652088388800621,
-0.0028890836983919144,
-0.029420427978038788,
-0.022307926788926125,
0.0034112785942852497,
0.015680639073252678,
0.00006462715828092769,
-0.05098278447985649,
-0.05008336901664734,
0.022674795240163803,
0.03282874822616577,
-0.03893532231450081,
0.014106657356023788
] | 2025-01-09 | 32 | 39781381 | [
"cervical cancer cells",
"cervical cancer cell lines",
"cervical cancer",
"advanced cervical cancer",
"primary human cervical cancer tissues",
"liquid cancers",
"adoptive immunotherapy displays",
"Anti-Mesothelin",
"Anti-Mesothelin CAR-NK cells",
"alpharetroviral SIN vectors",
"poor outcomes",
"Mesothelin",
"increased degranulation",
"CAR-NK-92 cells",
"patients",
"high cytotoxicity",
"a promising treatment strategy",
"SIN",
"CD28",
"natural killer (NK) cells",
"CAR",
"third",
"2D and 3D culture models",
"2D",
"the patients treatment outcome",
"CAR-NK-92",
"chimeric-antigen receptor",
"exposure",
"the currently available treatment paradigms",
"Resistance"
] | [
"CAR-NK cells",
"CAR-T cells",
"Mesothelin",
"cervical cancer",
"chemotherapy",
"chimeric antigen receptor (CAR)",
"immunotherapy"
] | 0 | 10.3389/fimmu.2024.1485461
10.1056/nejmoa1707447
10.1016/j.currproblcancer.2021.100826
10.1186/s13287-020-02128-1
10.1186/s13046-022-02327-z
10.3389/fimmu.2023.1105265
10.1007/s00404-018-4933-z
10.3390/biomedicines9040397
10.1006/mcbr.2000.0181
10.1128/MCB.20.8.2902-2906.2000
10.1074/jbc.M312372200
10.1186/s12967-024-05174-y
10.1172/jci.insight.99573
10.1158/2159-8290.CD-21-0407
10.1007/s00262-022-03238-w
10.3390/cancers15051357
10.1038/nbt0396-309
10.3390/v6124811
10.1128/jvi.00182-10
10.1182/blood-2001-11-0042
10.1016/j.ymthe.2005.08.012
10.1016/j.biomaterials.2014.01.057
10.1186/s13023-014-0126-4
10.1186/s12964-018-0215-4
10.1038/gt.2017.20
10.1016/j.ejso.2018.11.014
10.1200/JCO.20.01920
10.3389/fonc.2022.984896
10.3389/fmed.2021.756029
10.1158/1538-7445.AM2024-4007
10.1016/j.biopha.2020.110562
10.3390/biom12091296
10.1073/pnas.93.1.136
10.1007/s00404-020-05734-9
10.1136/jitc-2021-003826
10.3892/etm.2018.7015
10.7150/ijbs.64630
10.1016/j.bbrc.2020.01.053
10.1158/1078-0432.CCR-07-0869
10.1056/NEJMoa1709919
10.1126/science.aar6711
10.1038/s41408-021-00459-7
10.4161/onci.28147
10.1056/NEJMoa1910607
10.1016/j.bbmt.2018.12.758
10.1038/s41591-023-02785-8
10.1038/s41568-022-00491-0
10.1186/s12943-020-01238-x
10.3390/cancers15082323
10.3390/cancers15123225
10.3892/etm.2018.6342
10.1007/s00262-012-1212-x
10.3389/fimmu.2022.910595
10.1038/mt.2010.24
10.1038/mt.2010.272
10.1126/scitranslmed.aaa0984
10.1089/hum.2009.122
10.1158/2159-8290.CD-24-0096
10.4049/jimmunol.169.8.4230
10.1182/blood-2017-06-741041
10.1186/s12885-015-1321-y
10.3389/fimmu.2019.01133
10.32604/Oncologie.2021.015969
10.1016/j.ygyno.2019.05.005
10.3390/cancers12030694
10.3802/jgo.2023.34.e35
10.1016/j.stem.2021.03.012
10.1111/cas.14119
10.1182/blood.2024024166
10.3390/genes5020415
10.1038/mt.2011.309
10.3389/fimmu.2017.01194
10.1182/blood-2008-08-173914
10.4049/jimmunol.1201426
10.1186/s13045-016-0362-2
10.1038/sj.bjc.6604964
10.3389/fonc.2022.830570 | [
"Kutle",
"Polten",
"Stalp",
"Hachenberg",
"Todzey",
"Hass",
"Zimmermann",
"von der Ohe",
"von Kaisenberg",
"Neubert",
"Kamp",
"Schaudien",
"Seyda",
"Hillemanns",
"Klapdor",
"Morgan",
"Schambach"
] | [
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.\nDepartment of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.\nDepartment of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.",
"Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.",
"Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.",
"Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.",
"Institute of Pathology, Hannover Medical School, Hannover, Germany.\nBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.",
"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany.\nDepartment of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.",
"Fraunhofer Institute for Toxicology and Experimental Medicine, ITEM, Hannover, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.",
"Department of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.\nDepartment of Gynecology and Obstetrics, Hannover Medical School, Hannover, Germany.\nDepartment of Gynecology and Obstetrics, Albertinen Hospital Hamburg, Hamburg, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.",
"Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.\nDivision of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States."
] | [
"39781381",
"35012754",
"33494834",
"34980222",
"37180106",
"10683314",
"38637885",
"16226060",
"25103190",
"29329589",
"28346436",
"36387196",
"32920508",
"36139135",
"35091455",
"31980173",
"25340009",
"32762681",
"37370835",
"36045670",
"28724573",
"19719389",
"29118009",
"25933805",
"31191524",
"32183493",
"36659831",
"33852917",
"31265190",
"28993779",
"27903272",
"35692779"
] | [] | 11.026917 | 5.420137 |
39779871 | 56 | A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells. | Chimeric antigen receptor T cells (CAR T cells) with T stem (T | [
0.027601124718785286,
0.019044337794184685,
0.019252771511673927,
0.04633829742670059,
0.012506074272096157,
-0.03797897323966026,
-0.04034854471683502,
0.012780330143868923,
-0.007865662686526775,
-0.011793009005486965,
-0.028478745371103287,
-0.013855413533747196,
-0.03293266147375107,
-0.008353838697075844,
-0.005123102571815252,
-0.03806673362851143,
0.017848581075668335,
-0.03718911483883858,
0.0106027377769351,
0.03795703127980232,
0.002017152961343527,
0.013438545167446136,
0.018835904076695442,
0.007026439066976309,
-0.017969254404306412,
0.025231553241610527,
-0.004453917499631643,
-0.0061927009373903275,
-0.0007199220708571374,
-0.01332884281873703,
0.026350518688559532,
-0.02547289803624153,
-0.02201727218925953,
-0.02119450457394123,
0.028917554765939713,
0.04769860580563545,
-0.002896143589168787,
0.0181228369474411,
-0.03295460343360901,
-0.019910987466573715,
0.001545432605780661,
0.0234104935079813,
0.011803979054093361,
0.0677083283662796,
-0.029488006606698036,
-0.0005495405057445168,
-0.04238900914788246,
0.005339764524251223,
0.00009838934784056619,
0.02613111399114132,
-0.01443683635443449,
-0.02325691096484661,
-0.04032660648226738,
0.06647966057062149,
-0.05651868134737015,
0.029509946703910828,
-0.01348242536187172,
0.003540645120665431,
0.019603820517659187,
0.04034854471683502,
-0.02904919721186161,
-0.005109389778226614,
-0.01289003249257803,
-0.006488897372037172,
-0.03108966164290905,
-0.008178314194083214,
-0.037145234644412994,
-0.01930762268602848,
-0.00946731772273779,
0.019548969343304634,
0.009209517389535904,
-0.006664421409368515,
-0.004706233274191618,
-0.011162219569087029,
0.05752794072031975,
0.018210599198937416,
0.00982933584600687,
0.03040950745344162,
0.009445377625524998,
-0.0030990929808467627,
0.022423172369599342,
0.01042721327394247,
0.020799575373530388,
-0.0629253014922142,
-0.019527029246091843,
-0.046733226627111435,
0.016828348860144615,
-0.03811061754822731,
-0.02957576885819435,
-0.006642480846494436,
0.03657478094100952,
0.008721341378986835,
-0.02459527924656868,
0.012242788448929787,
0.010986695997416973,
0.021786898374557495,
-0.02648216113448143,
-0.062267087399959564,
0.005501575767993927,
0.007997305132448673,
0.06204768270254135,
-0.012089204974472523,
-0.04370543733239174,
-0.00940698105841875,
-0.004442947451025248,
0.018408063799142838,
-0.04015108197927475,
-0.0048515889793634415,
-0.02784247137606144,
-0.01042721327394247,
0.11409050226211548,
-0.0536225363612175,
0.009878701530396938,
0.05142848938703537,
-0.007739504799246788,
-0.05006817728281021,
-0.022796159610152245,
-0.02632857672870159,
-0.0029839053750038147,
-0.002449106192216277,
-0.002824836876243353,
-0.00006800692062824965,
0.0412919856607914,
-0.05489508435130119,
-0.03497312590479851,
0.001225924352183938,
0.07731825858354568,
-0.01622498594224453,
-0.027579184621572495,
-0.01915404014289379,
0.02406870760023594,
-0.011134793981909752,
0.025692302733659744,
0.0061762453988194466,
-0.017047753557562828,
0.0018046045443043113,
-0.05963422730565071,
-0.008150888606905937,
-0.05191117897629738,
-0.026021411642432213,
0.019724491983652115,
-0.04063377156853676,
-0.0028015251737087965,
-0.009215001948177814,
-0.0045361947268247604,
-0.018484855070710182,
-0.04616277292370796,
0.055290013551712036,
-0.015479009598493576,
0.042937520891427994,
-0.021819809451699257,
0.02135905809700489,
0.04611889272928238,
0.005487862974405289,
-0.006999013479799032,
-0.02459527924656868,
-0.014908556826412678,
0.03786927089095116,
-0.04306916519999504,
-0.027754709124565125,
-0.024178409948945045,
0.0006074770935811102,
-0.014787884429097176,
-0.02918083965778351,
0.0018238024786114693,
-0.0286981500685215,
-0.02663574367761612,
0.050331465899944305,
-0.07648451626300812,
0.01365794986486435,
-0.05344701185822487,
-0.02015233226120472,
-0.05809839442372322,
-0.021139653399586678,
-0.08907835185527802,
0.0018416291568428278,
0.03841778263449669,
0.03723299503326416,
-0.053754180669784546,
-0.018660379573702812,
0.034073568880558014,
0.05239386856555939,
0.01213308610022068,
0.005923930089920759,
0.0014192748349159956,
0.0031210335437208414,
-0.004815935622900724,
0.013241080567240715,
-0.022324439138174057,
-0.013076527044177055,
0.01795828342437744,
0.02034979686141014,
0.05691360682249069,
-0.01585199683904648,
0.01262674666941166,
-0.0410287007689476,
0.039054058492183685,
0.012100175023078918,
-0.005764861591160297,
-0.02253287471830845,
0.024156469851732254,
-0.01512796152383089,
-0.041599150747060776,
0.004464888013899326,
-0.01708066463470459,
0.006823489908128977,
-0.046557702124118805,
0.022006303071975708,
-0.033371470868587494,
-0.012517044320702553,
0.03538999706506729,
-0.015380277298390865,
-0.024551399052143097,
0.031857579946517944,
-0.04914667829871178,
-0.008661004714667797,
0.014974378049373627,
0.030497269704937935,
-0.0026835950557142496,
0.005605793092399836,
-0.04146751016378403,
-0.03431491181254387,
0.016323717311024666,
0.02275227941572666,
-0.08587504178285599,
0.00487352954223752,
0.02646022103726864,
-0.02628469653427601,
-0.02426617220044136,
0.011562633328139782,
-0.009900642558932304,
-0.004379868507385254,
-0.00431678956374526,
-0.021391969174146652,
-0.025714244693517685,
0.014524598605930805,
0.05871272832155228,
-0.01052046101540327,
0.06880535185337067,
-0.03141877055168152,
-0.03275713697075844,
0.028281280770897865,
0.061433348804712296,
-0.01727812923491001,
0.0012087833601981401,
-0.0065766591578722,
0.004453917499631643,
-0.0631885826587677,
-0.00303327152505517,
-0.015182812698185444,
0.030190102756023407,
0.012868092395365238,
-0.020975099876523018,
0.012604806572198868,
0.023695720359683037,
0.05221834406256676,
0.030190102756023407,
-0.01137613970786333,
0.02889561466872692,
-0.020393677055835724,
0.03089219704270363,
0.01983419433236122,
-0.019603820517659187,
-0.032537732273340225,
-0.02409064769744873,
0.013888324610888958,
0.003038756549358368,
0.00879264809191227,
0.04015108197927475,
-0.008518392220139503,
-0.005438496824353933,
0.024375874549150467,
0.03126518428325653,
-0.0067741237580776215,
-0.0533592514693737,
-0.0045361947268247604,
-0.009982919320464134,
0.023520195856690407,
0.01706969365477562,
0.028763970360159874,
-0.014458777382969856,
0.02887367270886898,
0.005323309451341629,
0.03130906820297241,
-0.03571910411119461,
-0.02065696381032467,
0.0009845790918916464,
0.002451848704367876,
0.009231457486748695,
-0.035587459802627563,
0.03376640006899834,
-0.0066863615065813065,
0.003771020332351327,
-0.03345923498272896,
-0.04510962963104248,
0.03106772154569626,
-0.026547983288764954,
-0.005216349381953478,
-0.027908291667699814,
-0.01408578921109438,
-0.024661101400852203,
-0.02253287471830845,
-0.03960257023572922,
-0.027732769027352333,
0.02918083965778351,
0.02525349333882332,
-0.014996319077908993,
-0.05230610817670822,
0.020580170676112175,
0.005699039902538061,
0.022126974537968636,
-0.03710135444998741,
0.047391440719366074,
-0.0012924314942210913,
0.00828253198415041,
-0.012670627795159817,
-0.028303220868110657,
-0.029290542006492615,
0.03824225813150406,
-0.08175023645162582,
0.00940698105841875,
-0.015424158424139023,
-0.011573604308068752,
-0.00793696939945221,
-0.009428922086954117,
0.010026799514889717,
0.04164303466677666,
-0.015424158424139023,
-0.001915678265504539,
-0.03879076987504959,
0.006302403286099434,
-0.03534611687064171,
0.08052156865596771,
-0.005808742251247168,
0.014820795506238937,
0.0010065195383504033,
-0.012999734841287136,
-0.054938964545726776,
0.01655409298837185,
-0.0027110206428915262,
0.007081290241330862,
0.030804436653852463,
-0.057176895439624786,
0.06586532294750214,
-0.0344904363155365,
-0.01912112906575203,
0.0072787548415362835,
0.002901628613471985,
0.011573604308068752,
-0.04012914001941681,
-0.0006976387230679393,
0.04568008333444595,
0.014195491559803486,
-0.027206197381019592,
-0.020130392163991928,
0.017980223521590233,
0.002918083919212222,
-0.023498255759477615,
0.026899030432105064,
0.0005639389273710549,
0.057966750115156174,
0.0205143503844738,
-0.034775663167238235,
0.010383333079516888,
0.0737638995051384,
0.047391440719366074,
-0.019856136292219162,
0.04298140108585358,
-0.021435849368572235,
-0.0652071088552475,
-0.02970741130411625,
-0.0011601028963923454,
0.03275713697075844,
0.037825390696525574,
-0.03124324604868889,
0.008693915791809559,
0.04048018902540207,
0.03797897323966026,
0.00443746242672205,
-0.003326725447550416,
0.024902446195483208,
-0.01813380792737007,
-0.0213371179997921,
-0.03554357960820198,
-0.009615415707230568,
0.010449154302477837,
0.02595558948814869,
0.03139682859182358,
-0.02610917203128338,
0.022796159610152245,
-0.029136959463357925,
-0.024024827405810356,
0.029839053750038147,
0.013833473436534405,
-0.021556522697210312,
0.035938508808612823,
0.006445016246289015,
0.060555730015039444,
-0.005290398374199867,
0.008825558237731457,
-0.013098467141389847,
-0.025845887139439583,
-0.01024071965366602,
-0.05327148735523224,
0.034600138664245605,
0.0033870618790388107,
0.03602626919746399,
0.004319532308727503,
0.021446820348501205,
-0.035258352756500244,
0.024046767503023148,
0.00007019240001682192,
0.02786441147327423,
0.04151139035820961,
-0.0029455095063894987,
0.0009701806702651083,
-0.046206653118133545,
0.01846291497349739,
0.019219862297177315,
0.03464401885867119,
0.012418312020599842,
-0.01530348602682352,
0.03655284270644188,
-0.004105612635612488,
-0.027579184621572495,
-0.010734380222856998,
0.041050639003515244,
0.026394398882985115,
0.006560204084962606,
-0.00914369523525238,
0.0036092090886086226,
0.05450015515089035,
-0.009944522753357887,
-0.027732769027352333,
0.020031658932566643,
0.005049053113907576,
-0.055290013551712036,
-0.0030113309621810913,
-0.053885821253061295,
0.0074158827774226665,
-0.03413938730955124,
0.014930497854948044,
0.047610845416784286,
-0.026262756437063217,
0.0071909925900399685,
-0.018035076558589935,
-0.010866023600101471,
-0.00786017719656229,
-0.09109687805175781,
-0.015819087624549866,
-0.0019293910590931773,
-0.0034172299783676863,
-0.02323496900498867,
0.0006376452511176467,
-0.03431491181254387,
-0.01305458601564169,
0.03966838866472244,
-0.004105612635612488,
0.01861649751663208,
0.031857579946517944,
0.023673778399825096,
-0.02714037522673607,
0.02218182571232319,
-0.03468790277838707,
0.012363460846245289,
0.05191117897629738,
-0.009006567299365997,
0.007251329254359007,
0.015084081329405308,
-0.005306853912770748,
0.011716216802597046,
0.010235234163701534,
-0.02663574367761612,
0.044144246727228165,
-0.00021494815882761031,
0.009659296832978725,
0.02803993597626686,
0.029093077406287193,
0.04396872594952583,
-0.04151139035820961,
-0.012319580651819706,
-0.008940746076405048,
-0.041226163506507874,
0.028281280770897865,
0.01058628223836422,
-0.00048131932271644473,
-0.007827267050743103,
-0.001478239893913269,
0.0003891007218044251,
-0.011518753133714199,
-0.025582600384950638,
0.00743233785033226,
-0.010416243225336075,
-0.009099815040826797,
-0.0015947987558320165,
-0.012495104223489761,
0.010284600779414177,
-0.008063127286732197,
-0.025582600384950638,
-0.011321288533508778,
-0.03277907893061638,
0.016806408762931824,
0.0019403613405302167,
0.023717660456895828,
0.03229638934135437,
0.06288141757249832,
0.0151060214266181,
0.050463106483221054,
0.005858108401298523,
0.015479009598493576,
0.004393581300973892,
-0.024288112297654152,
0.03668448328971863,
-0.013712801039218903,
-0.02270839735865593,
-0.02083248645067215,
-0.05125296488404274,
-0.03672836720943451,
0.015588711947202682,
0.005098419263958931,
-0.011134793981909752,
0.010032285004854202,
0.004278393927961588,
-0.006768638268113136,
0.04374932125210762,
-0.02168816514313221,
0.0012245530961081386,
-0.06450501829385757,
-0.025845887139439583,
-0.018550677224993706,
0.020218154415488243,
-0.011299347504973412,
0.012670627795159817,
0.01675155758857727,
0.00277821347117424,
-0.003998652566224337,
-0.015819087624549866,
0.017190366983413696,
-0.0047391438856720924,
-0.05533389374613762,
0.020569201558828354,
0.0029701925814151764,
0.020459499210119247,
-0.00641210563480854,
-0.010048740543425083,
0.01915404014289379,
0.012593836523592472,
-0.050989679992198944,
0.027710827067494392,
0.015830056741833687,
0.04017302021384239,
-0.01655409298837185,
0.03569716215133667,
0.004006880335509777,
0.009017538279294968,
-0.05770346522331238,
-0.003227993380278349,
-0.011058002710342407,
0.003326725447550416,
-0.0344904363155365,
-0.0400194376707077,
-0.016159163787961006,
0.01434907503426075,
-0.040897056460380554,
-0.04730367660522461,
0.047918010503053665,
-0.020086510106921196,
0.017398802563548088,
-0.0392734631896019,
-0.002043207408860326,
-0.00863357912749052,
0.01504020020365715,
0.011650395579636097,
-0.008441600017249584,
0.029093077406287193,
0.010021314956247807,
-0.005616763141006231,
0.010405273176729679,
-0.03958062827587128,
0.015994610264897346,
-0.023893184959888458,
-0.04096287861466408,
0.022927802056074142,
0.013537276536226273,
-0.026438279077410698,
0.012418312020599842,
-0.025165732949972153,
-0.023103326559066772,
-0.028632327914237976,
0.0028111240826547146,
0.04888339340686798,
0.018879784271121025,
0.04853234440088272,
0.025999469682574272,
-0.01602752134203911,
0.014480717480182648,
0.00674121268093586,
-0.030870256945490837,
-0.04993653669953346,
-0.0038862077053636312,
-0.00631337333470583,
-0.00631337333470583,
0.001254721311852336,
-0.02718425542116165,
-0.020108450204133987,
0.008315442129969597,
-0.007602376863360405,
-0.003754564793780446,
-0.00563870370388031,
0.021073833107948303,
0.035455819219350815,
0.022510934621095657,
-0.025077970698475838,
0.03865912929177284,
0.04796189069747925,
0.0286981500685215,
-0.00661505525931716,
-0.017651116475462914,
-0.005353477317839861,
-0.026701565831899643,
-0.00974705908447504,
-0.019691582769155502,
-0.03398580476641655,
0.018067985773086548,
-0.022949744015932083,
-0.026262756437063217,
0.015424158424139023,
0.011420020833611488,
0.002458705101162195,
-0.018715230748057365,
-0.04249871149659157,
0.01196853257715702,
0.003872494911774993,
0.06731339544057846,
-0.02273033931851387,
-0.014041908085346222,
0.021435849368572235,
0.0028083815705031157,
-0.004678807687014341,
0.015149902552366257,
-0.013241080567240715,
-0.015446098521351814,
-0.0344904363155365,
-0.03207698464393616,
0.04153333231806755,
0.0071142008528113365,
-0.011793009005486965,
0.01777178980410099,
0.017969254404306412,
0.003864267375320196,
-0.007520100101828575,
-0.030804436653852463,
0.03958062827587128,
-0.03187951818108559,
-0.012966824695467949,
-0.036794185638427734,
-0.008968171663582325,
-0.005693554878234863,
0.05827391892671585,
0.06489994376897812,
-0.028742030262947083,
0.013965116813778877,
-0.01691611111164093,
-0.03769374638795853,
-0.011140279471874237,
0.006966102868318558,
0.009099815040826797,
0.0036503474693745375,
-0.019373444840312004,
-0.0021227416582405567,
0.08618220686912537,
0.006390165071934462,
0.010701470077037811,
-0.0424109511077404,
-0.0016688478644937277,
-0.002698679221794009,
-0.013350782915949821,
-0.007646257523447275,
-0.01846291497349739,
0.0031402313616126776,
0.006680876482278109,
0.019011426717042923,
-0.031506530940532684,
-0.0591515377163887,
-0.0006277034408412874,
-0.025867827236652374,
-0.0029263116884976625,
-0.012593836523592472,
-0.02018524333834648,
-0.009346645325422287,
-0.036487020552158356,
0.008046671748161316,
-0.013668919913470745,
-0.01808992773294449,
0.02166622504591942,
0.0005557112745009363,
0.005737436003983021,
0.018671348690986633,
0.006461471784859896,
0.019856136292219162,
0.00820573978126049,
0.009165636263787746,
0.04133586585521698,
-0.008419659920036793,
0.03672836720943451,
-0.022686457261443138,
0.0176182072609663,
0.0043826112523674965,
0.015336396172642708,
0.06941968202590942,
-0.01444780733436346,
-0.02030591480433941,
-0.015084081329405308,
-0.022774219512939453,
0.006357254460453987,
-0.0014960665721446276,
0.009352129884064198,
0.057352419942617416,
0.009028508327901363,
0.009922582656145096,
-0.007048379629850388,
0.021556522697210312,
-0.011101883836090565,
-0.0041686915792524815,
0.032208625227212906,
-0.00365309021435678,
-0.009456347674131393,
0.03005846031010151,
-0.03359087556600571,
-0.0034172299783676863,
-0.014283252879977226,
-0.028105756267905235,
-0.030321745201945305,
0.001261577708646655,
-0.005989751312881708,
0.025407077744603157,
-0.026174994185566902,
-0.017025813460350037,
-0.015336396172642708,
-0.02153458259999752,
0.024704981595277786,
-0.004969519097357988,
-0.010690499097108841,
0.014711093157529831,
-0.015489979647099972,
0.03861524537205696,
0.029268601909279823,
0.0024655614979565144,
-0.0183093324303627,
-0.047391440719366074,
0.00041858325130306184,
0.004802222829312086,
-0.017881492152810097,
-0.01607140339910984,
-0.0031813697423785925,
-0.03207698464393616,
-0.013043615967035294,
-0.026920970529317856,
-0.016499241814017296,
-0.02308138646185398,
-0.015654534101486206,
-0.009604445658624172,
0.007838237099349499,
-0.0017662087921053171,
0.02459527924656868,
0.0027535303961485624,
0.019351504743099213,
0.009099815040826797,
0.002940024482086301,
0.012231818400323391,
-0.03876883164048195,
-0.00007627745799254626,
-0.030694732442498207,
-0.0027672431897372007,
-0.027974113821983337,
-0.000022733252990292385,
-0.005753891076892614,
-0.01793634332716465,
-0.06081901490688324,
0.005912959575653076,
-0.015972670167684555,
0.02338855341076851,
-0.04377125948667526,
0.013888324610888958,
-0.002187191741541028,
-0.00226398347876966,
0.0002074061194434762,
0.0066205402836203575,
-0.0458117239177227,
-0.01845194399356842,
-0.018835904076695442,
0.022445112466812134,
-0.05502672865986824,
0.003954771906137466,
0.003834099043160677,
0.020119421184062958,
0.030694732442498207,
-0.08144306391477585,
-0.0075584957376122475,
-0.002531382953748107,
0.006669906433671713,
-0.023651838302612305,
0.015095051378011703,
-0.024134529754519463,
-0.008863954804837704,
0.009313734248280525,
0.0012341521214693785,
0.0028879158198833466,
0.016345659270882607,
0.002720619784668088,
-0.010131017304956913,
0.00661505525931716,
-0.03060697205364704,
-0.00017303841013927013,
-0.04853234440088272,
-0.0074158827774226665,
0.008326413109898567,
0.0063298288732767105,
0.0011230784002691507,
-0.02834710106253624,
0.03521447256207466,
-0.011617484502494335,
-0.007574951276183128,
-0.006307888310402632,
0.00674121268093586,
-0.021622344851493835,
-0.023783482611179352,
0.034600138664245605,
0.013646979816257954,
-0.000013766366464551538,
0.046689342707395554,
-0.030014578253030777,
-0.028061876073479652,
0.015522890724241734,
-0.019878076389431953,
-0.0085293622687459,
-0.006450501270592213,
0.009538624435663223,
-0.008814588189125061,
0.018671348690986633,
0.02376154065132141,
-0.00641210563480854,
-0.00268770894035697,
-0.051867298781871796,
-0.009741573594510555,
0.042630355805158615,
-0.0005886220023967326,
0.03639926016330719,
-0.019570909440517426,
-0.03771568834781647,
0.01568744331598282,
0.0005097733810544014,
-0.006746698170900345,
-0.0032005677931010723,
0.03703553229570389,
0.012714508920907974,
0.041094522923231125,
-0.016850288957357407,
0.07222806662321091,
0.02459527924656868,
-0.019077248871326447,
0.01689417101442814,
-0.02082151733338833,
-0.044846344739198685,
0.020810546353459358,
-0.015051170252263546,
0.018320301547646523,
-0.028105756267905235,
0.00879813265055418,
-0.010953784920275211,
-0.005367190111428499,
0.006417590659111738,
-0.0024792742915451527,
-0.023278851062059402,
0.011760097928345203,
0.015116991475224495,
-0.013306901790201664,
-0.01348242536187172,
-0.0007514614844694734,
-0.015742294490337372,
-0.004215314984321594,
-0.03694777190685272,
-0.008304472081363201,
0.006417590659111738,
0.01996583864092827,
0.020799575373530388,
-0.0021213702857494354,
-0.008490966632962227,
0.00046760650002397597,
-0.005010657478123903,
-0.0003705884446389973,
0.008194769732654095,
-0.0015851997304707766,
-0.061740513890981674,
0.017311040312051773,
0.005227319896221161,
-0.01272547896951437,
0.03620179370045662,
-0.018243510276079178,
0.00044806578080169857,
-0.027052612975239754,
-0.033195946365594864,
-0.025363195687532425,
0.028983375057578087,
-0.0011697019217535853,
0.01624692603945732,
-0.030519209802150726,
0.023871243000030518,
-0.011217070743441582,
0.01305458601564169,
-0.005389130674302578,
-0.011310318484902382,
0.03797897323966026,
0.010098106227815151,
-0.028676209971308708,
0.033415354788303375,
-0.010915389284491539,
0.056825846433639526,
0.005531743634492159,
0.03126518428325653,
-0.045021869242191315,
0.011782038025557995,
0.0005389130674302578,
-0.0032252506352961063,
0.027645006775856018,
0.01587393879890442,
-0.020558230578899384,
0.03040950745344162,
0.006713787093758583,
0.018901724368333817,
-0.003485793946310878,
0.010591767728328705,
0.04642605781555176,
0.02134808897972107,
0.00665893591940403,
0.007163567002862692,
0.042608413845300674,
-0.012451223097741604,
-0.01323011051863432,
0.005287656094878912,
-0.03433685377240181,
0.01915404014289379,
-0.028237398713827133,
-0.02444169670343399,
0.05520224943757057,
-0.010564342141151428,
0.022236676886677742,
-0.03644314035773277,
0.010608222335577011,
-0.0010901676723733544,
0.026087231934070587,
-0.005268458276987076,
0.01608237251639366,
0.014107729308307171,
-0.010992181487381458,
-0.0320989228785038,
-0.0049119251780211926,
-0.033722519874572754,
0.028390983119606972,
-0.02168816514313221,
-0.0008975028176791966,
-0.0206459928303957,
-0.01451362855732441,
0.00448957085609436,
0.026920970529317856,
0.023191088810563087,
0.02221473678946495,
0.012484134174883366,
-0.05994139611721039,
0.023695720359683037,
-0.01808992773294449,
-0.03710135444998741,
0.014217431657016277,
0.028456803411245346,
-0.0003699027874972671,
0.023542135953903198,
0.04324468970298767,
-0.04546067863702774,
-0.012418312020599842,
0.024331994354724884,
0.024858566001057625,
0.019724491983652115,
0.007849207147955894,
0.0007638030219823122,
-0.01487564668059349,
0.02016330324113369,
-0.0028412924148142338,
-0.03547775745391846,
-0.05068251118063927,
0.010015829466283321,
0.021062862128019333,
0.03317400813102722,
0.019921956583857536,
-0.028676209971308708,
0.006966102868318558,
-0.029158899560570717,
-0.02698679268360138,
-0.04563619941473007,
0.01127740740776062,
0.009072389453649521,
0.004837876185774803,
-0.011628455482423306,
0.010004859417676926,
0.010794716887176037,
-0.029839053750038147,
-0.003444655565544963,
0.019208891317248344,
0.012791300192475319,
0.020931219682097435,
-0.006428561173379421,
0.008858469314873219,
0.026547983288764954,
-0.008622609078884125,
0.04866398870944977,
0.001976014580577612,
-0.0025450957473367453,
0.009516683407127857,
-0.03157235309481621,
-0.015610652044415474,
-0.01859455741941929,
-0.022434141486883163,
0.010295570828020573,
-0.005742921028286219,
-0.0027603867929428816,
0.028676209971308708,
-0.024200350046157837,
0.022456083446741104,
-0.028325160965323448,
0.017804700881242752,
0.02084345743060112,
-0.0018087184289470315,
-0.0038094159681349993,
0.01637856848537922,
-0.0010785118211060762,
-0.02154555171728134,
0.014886616729199886,
-0.00973060354590416,
0.03438073396682739,
0.01875911094248295,
-0.012615776620805264,
-0.02836904302239418,
0.01401996798813343,
0.010037770494818687,
0.05607987195253372,
-0.022247647866606712,
0.001007205224595964,
-0.019954867660999298,
-0.030650852248072624,
0.008244135417044163,
0.0526132732629776,
0.018067985773086548,
0.02922472171485424,
0.00512858759611845,
-0.011228041723370552,
0.010196838527917862,
-0.011913681402802467,
0.009434406645596027,
0.010109077207744122,
0.02205018326640129,
0.015018259175121784,
-0.02615305408835411,
0.021424880251288414,
-0.0034885364584624767,
-0.008611639030277729,
0.024726921692490578,
-0.0056112781167030334,
0.014283252879977226,
0.02735977992415428,
0.026920970529317856,
0.03569716215133667,
0.002183077856898308,
-0.015018259175121784,
0.006445016246289015,
0.02205018326640129,
-0.0017950056353583932,
-0.02099703997373581,
0.012517044320702553,
-0.01170524675399065,
-0.027710827067494392,
-0.03473178297281265,
0.002055548829957843,
0.02356407605111599,
0.007657228037714958,
0.0131533183157444,
0.007832751609385014,
0.016510212793946266,
-0.025933649390935898,
-0.01348242536187172,
-0.035126712173223495,
-0.022094065323472023,
0.006702817045152187,
-0.005265715532004833,
-0.020788606256246567,
0.005792287178337574,
0.026174994185566902,
-0.016367599368095398,
-0.03626761585474014,
0.006982558406889439,
0.029619649052619934,
-0.019186951220035553,
-0.018254481256008148,
0.04357379674911499,
-0.005918444599956274,
0.01553386077284813,
-0.03822031989693642,
0.041270043700933456,
-0.005400101188570261,
-0.03995361551642418,
0.018078956753015518,
0.007585921324789524,
-0.028983375057578087,
0.021402940154075623,
0.01658700406551361,
-0.035258352756500244,
0.020371736958622932,
-0.004152236040681601,
-0.0028796882834285498,
-0.03793509304523468,
0.015018259175121784,
0.0005491976626217365,
-0.0167405866086483,
-0.04629441723227501,
0.021622344851493835,
0.0058251977898180485,
-0.011814949102699757,
0.008233165368437767,
-0.00820025522261858,
0.016872230917215347,
-0.012571895495057106,
0.028632327914237976,
-0.013559217564761639,
-0.035082828253507614,
-0.012506074272096157,
-0.004670579917728901,
-0.015632592141628265,
0.0016427935333922505,
-0.007547525689005852,
-0.019044337794184685,
0.0184409748762846,
-0.0088749248534441,
0.0021213702857494354,
0.002002069028094411,
-0.01001034490764141,
0.008507421240210533,
-0.018748141825199127,
0.005482377950102091,
-0.015314456075429916,
0.05019982159137726,
-0.01946120709180832,
-0.03317400813102722,
0.04510962963104248,
-0.036135971546173096,
-0.026569923385977745,
-0.01655409298837185,
0.004421006888151169,
0.006296918261796236,
-0.004154978785663843,
0.005633218679577112,
0.024002887308597565,
0.032910723239183426,
-0.01546803954988718,
-0.012330550700426102,
0.01504020020365715,
-0.024024827405810356,
-0.028105756267905235,
-0.002088459674268961,
0.003447398077696562,
0.005060023628175259,
0.0016935309395194054,
-0.009023022837936878,
0.0006979815661907196,
0.026789328083395958,
-0.002359973033890128,
0.008222195319831371,
0.021973391994833946,
0.02714037522673607,
0.05002429708838463,
0.014206461608409882,
-0.03159429132938385,
0.00537541788071394,
-0.03464401885867119,
-0.01829836145043373,
-0.013295931741595268,
-0.0138444434851408,
-0.03582880645990372,
-0.010564342141151428,
-0.02168816514313221,
-0.027886351570487022,
-0.02068987302482128,
0.03532417491078377,
-0.005731950514018536,
-0.027623066678643227,
-0.03179175779223442,
-0.016499241814017296,
-0.028829792514443398,
0.011074458248913288,
-0.002026751870289445,
-0.034797605127096176,
0.00836480874568224,
0.020931219682097435,
-0.0004343529581092298,
0.009215001948177814,
0.0286981500685215,
0.008573243394494057,
-0.009105299599468708,
0.007454278413206339,
0.026920970529317856,
-0.018561646342277527,
-0.0017086149891838431,
-0.04205990210175514,
0.014316163957118988,
-0.024639161303639412,
-0.008386748842895031,
-0.008008276112377644,
-0.006242067087441683,
-0.009012052789330482,
-0.014239372685551643,
0.008342867717146873,
0.006181730423122644,
0.011217070743441582,
-0.03438073396682739,
-0.015138932503759861,
-0.008194769732654095,
0.05471955984830856,
0.008995597250759602,
-0.06507546454668045,
0.03756210580468178,
-0.02356407605111599,
0.005252002738416195,
0.024288112297654152,
-0.00862809456884861,
-0.027447542175650597,
-0.005070993676781654,
-0.037649866193532944,
0.02766694687306881,
0.005062765907496214,
-0.006785093806684017,
0.00818928424268961,
-0.023169148713350296,
0.043464094400405884,
0.001513893250375986,
0.02786441147327423,
-0.03212086483836174,
0.010131017304956913,
-0.005512545816600323,
0.01529251504689455,
0.022291529923677444,
0.02751336432993412,
-0.0007178651285357773,
-0.030804436653852463,
0.0012012413935735822,
-0.01587393879890442,
-0.026723505929112434,
-0.00888040941208601,
-0.01117867510765791,
0.006296918261796236,
0.01034493651241064,
-0.027601124718785286,
-0.007361031603068113,
-0.013954145833849907,
0.03216474503278732,
-0.00004478086339076981,
-0.037496283650398254,
0.002261240966618061,
-0.03091413900256157,
-0.0005937642999924719,
-0.003422715002670884,
0.03073861449956894,
0.009001082740724087,
0.030541149899363518,
-0.019439266994595528,
0.013515336439013481,
-0.012966824695467949,
0.045197390019893646,
0.024178409948945045,
0.02321302890777588,
-0.0392734631896019,
-0.05125296488404274,
0.03192340210080147,
0.01810089685022831,
-0.02116159349679947,
0.025143790990114212,
0.02953188866376877,
-0.003403517184779048,
0.006477927323430777,
0.05019982159137726,
-0.022840041667222977,
0.012056294828653336,
-0.025714244693517685,
-0.008315442129969597,
-0.0017250702949240804,
-0.020953159779310226,
0.0053205667063593864,
-0.010613707825541496,
-0.003655832726508379,
-0.018890755251049995,
-0.016126254573464394,
-0.0011847859714180231,
-0.02134808897972107,
0.014722063206136227,
0.01487564668059349,
0.02406870760023594,
0.02373960055410862,
-0.033195946365594864,
-0.045855604112148285,
0.03775956854224205,
0.02542901784181595,
-0.0212054755538702,
-0.010328481905162334,
-0.028610387817025185,
0.0020102965645492077,
0.05779122933745384,
-0.03642119839787483,
-0.0005426841089501977,
0.005117617081850767,
0.0006304460112005472,
-0.020459499210119247,
0.008474511094391346,
0.02628469653427601,
0.008896864950656891,
-0.013767652213573456,
0.011332258582115173,
-0.018408063799142838,
0.0024271656293421984,
0.027930233627557755,
-0.005347992293536663,
-0.008227680809795856,
0.01861649751663208,
-0.0059019895270466805,
-0.0032417061738669872,
-0.01052046101540327,
-0.02084345743060112,
0.047566965222358704,
-0.01999874785542488,
0.007947939448058605,
-0.01949411816895008,
0.0023791708517819643,
-0.03038756735622883,
0.0015468039782717824,
0.024485576897859573,
0.00198149960488081,
-0.02665768563747406,
0.012659657746553421,
0.0206459928303957,
-0.03453431650996208,
-0.0160494614392519,
0.002735703717917204,
0.03859330713748932,
0.0088749248534441,
-0.005205379333347082,
0.027886351570487022,
-0.010789231397211552,
-0.015643563121557236,
-0.012813241221010685,
-0.023366613313555717,
-0.04372737929224968,
-0.022861981764435768,
0.012187937274575233,
-0.007059349678456783,
0.014744003303349018,
0.01791440322995186,
0.006110424175858498,
-0.015764236450195312,
-0.028434863314032555,
0.010301056317985058,
-0.003291072091087699,
-0.029970698058605194,
-0.007372001651674509,
-0.019932927563786507,
-0.023366613313555717,
0.008721341378986835,
-0.04352991655468941,
-0.0011093656066805124,
-0.0011498183012008667,
-0.01305458601564169,
0.012484134174883366,
-0.004977746866643429,
-0.01637856848537922,
0.009472803212702274,
-0.0032389636617153883,
0.006077513098716736,
0.013361752964556217,
-0.022927802056074142,
-0.04747920110821724,
0.0005577681586146355,
-0.035631339997053146,
0.007229388691484928,
-0.05432463064789772,
0.01693805120885372,
0.006856400519609451,
0.018868813291192055,
-0.022993624210357666,
0.047742486000061035,
0.014886616729199886,
0.019735462963581085,
-0.014414896257221699,
0.021095773205161095,
0.0065766591578722,
0.04515350982546806,
0.0009749801247380674,
-0.0005629104562103748,
0.007684653624892235,
-0.017497533932328224,
0.024288112297654152,
0.016970962285995483,
-0.019197920337319374,
-0.024858566001057625,
-0.026240816339850426,
0.0004840618639718741,
0.009703177958726883,
-0.04954160749912262,
-0.024639161303639412,
0.0021913056261837482,
-0.012922943569719791,
0.001160788582637906,
0.006006206851452589,
0.03093607909977436,
0.01239637192338705,
0.03484148532152176,
-0.011913681402802467,
0.020031658932566643,
-0.0007103231037035584,
0.019878076389431953,
-0.015610652044415474,
0.014162580482661724,
0.023542135953903198,
-0.030716674402356148,
-0.016115283593535423,
0.03514865040779114,
0.010745350271463394,
-0.031682055443525314,
0.029290542006492615,
-0.03438073396682739,
0.00913821067661047,
-0.006763153243809938,
-0.01607140339910984,
0.009549594484269619,
-0.02166622504591942,
0.023454373702406883,
0.017903432250022888,
0.026920970529317856,
-0.02525349333882332,
0.02086539752781391,
0.006653450895100832,
-0.016005581244826317,
-0.004050761461257935,
0.006307888310402632,
-0.035104770213365555,
0.010608222335577011,
0.01945023611187935,
0.004207087215036154,
0.005836167838424444,
0.012670627795159817,
-0.018419034779071808,
0.016707677394151688,
0.005896504502743483,
0.001867683487944305,
0.03488536551594734,
-0.017892463132739067,
0.006274977698922157,
-0.00015049798821564764,
0.03896629437804222,
-0.012747419998049736,
0.04730367660522461,
0.00854581780731678,
-0.0066205402836203575,
-0.011387109756469727,
-0.02595558948814869,
-0.008573243394494057,
-0.003068924881517887,
0.01365794986486435,
0.10917583853006363,
-0.0009139581816270947,
0.01671864651143551,
0.018901724368333817,
0.019702551886439323,
0.0012828324688598514,
-0.0061049391515553,
0.00836480874568224,
-0.01434907503426075,
-0.0006770695326849818,
0.03907599672675133,
-0.012286669574677944,
0.015676474198698997,
-0.005614020861685276,
0.028237398713827133,
-0.02185271866619587,
0.022456083446741104,
0.037123292684555054,
-0.0037243966944515705,
0.028149638324975967,
0.009796424768865108,
0.038176435977220535,
-0.02766694687306881,
-0.018331272527575493,
-0.007169052492827177,
-0.009275338612496853,
0.018539706245064735,
0.004612985998392105,
-0.02648216113448143,
-0.018737170845270157,
0.008227680809795856,
0.02050337940454483,
0.011036061681807041,
0.019263742491602898,
-0.03517059236764908,
-0.02735977992415428,
-0.011880770325660706,
-0.023015564307570457,
0.04651382192969322,
0.01367988996207714,
-0.012911973521113396,
0.020722784101963043,
0.002698679221794009,
0.013789592310786247,
0.026218874379992485,
0.01477691438049078,
0.0039026630111038685,
-0.01606043241918087,
0.007865662686526775,
-0.04651382192969322,
0.02714037522673607,
0.004695263225585222,
0.0263066366314888,
-0.015281544998288155,
-0.027601124718785286,
-0.008825558237731457,
0.022861981764435768,
-0.0003064810880459845,
-0.009198546409606934,
-0.01391026470810175,
-0.03925152122974396,
0.02323496900498867,
0.0048104505985975266,
0.022664517164230347,
0.027293959632515907
] | 2025-01-09 | 59 | 39779871 | [
"Chimeric antigen receptor T cells",
"CAR T cells",
"T",
"T stem"
] | [] | 0 | 10.1038/s41590-024-02042-1
10.1200/JCO.2014.56.2025
10.1056/NEJMoa1817226
10.1200/JCO.20.01342
10.1056/NEJMoa1407222
10.1182/blood-2017-06-786129
10.1182/bloodadvances.2019000525
10.1016/S0140-6736(21)01222-8
10.1182/bloodadvances.2020003959
10.1016/j.addr.2022.114421
10.1182/blood-2018-11-887067
10.1200/JCO.19.02104
10.1182/blood.2020007445
10.1182/bloodadvances.2021005385
10.1182/blood-2011-05-354449
10.1172/JCI85309
10.1038/s41586-021-04390-6
10.1172/JCI24480
10.1038/nm.2446
10.1182/blood-2014-01-552174
10.1182/bloodadvances.2020002394
10.1158/1078-0432.CCR-17-0432
10.1038/nm.1982
10.1172/JCI32103
10.1182/blood-2010-05-286286
10.1182/blood-2012-05-431718
10.1038/nri3403
10.1126/scitranslmed.aau5907
10.1126/science.aba1786
10.1016/j.ccell.2020.05.004
10.18632/oncotarget.26334
10.3389/fimmu.2017.01221
10.1158/2326-6066.CIR-14-0186
10.1182/blood-2012-11-468660
10.1016/j.immuni.2009.02.003
10.1016/j.ccell.2019.12.014
10.1158/1078-0432.CCR-18-1811
10.1074/jbc.RA119.011083
10.1177/2472555218773045
10.1093/nar/gkz446
10.1038/s41590-018-0311-z
10.1084/jem.20170697
10.1126/sciimmunol.aai8593
10.1126/sciimmunol.adh1306
10.1172/JCI148546
10.1038/s41591-018-0010-1
10.1038/s41591-020-1061-7
10.1021/acs.jproteome.3c00182
10.1172/JCI69589
10.1038/s41598-024-68102-6
10.1021/acsinfecdis.5b00136
10.1126/scisignal.aav7259
10.1038/nbt.1511
10.1038/nmeth.3901
10.1172/JCI86000
10.1016/j.ymthe.2017.01.011
10.1186/gb-2008-9-9-r137
10.1016/j.ccell.2019.01.002 | [
"Song",
"Tsahouridis",
"Stucchi",
"Walhart",
"Mendell",
"Hardy",
"Axtman",
"Guduru",
"Gilbert",
"Graves",
"Herring",
"Savoldo",
"Ma",
"Woodcock",
"Milner",
"Ivanova",
"Pearce",
"Xu",
"Dotti"
] | [
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Michael Hooker Proteomics Center, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.\nDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.\nDepartment of Oncology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.\nOncology division, department of medicine, University of North Carolina, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.\nDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [email protected].\nSchool of Medicine, Southern University of Science and Technology, Shenzhen, China. [email protected].",
"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [email protected].\nDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [email protected]."
] | [
"39779871",
"25154820",
"31042825",
"32701411",
"25317870",
"28935694",
"32045475",
"34097852",
"34100900",
"35809868",
"30782611",
"32401634",
"33512407",
"34666347",
"21984804",
"27111235",
"35110735",
"15931392",
"21926977",
"24782509",
"33035333",
"29138340",
"19525962",
"18060041",
"20971955",
"23160470",
"23524462",
"31270272",
"33795428",
"32516591",
"30533195",
"29033940",
"25600436",
"2370865",
"23349370",
"19285438",
"32004441",
"30617136",
"31896573",
"29742358",
"31114921",
"30778251",
"29282254",
"28018990",
"37862431",
"34981777",
"29713085",
"33020644",
"37634194",
"24091329",
"39060313",
"26998514",
"31311847",
"19029910",
"27348712",
"27270177",
"28187946",
"18798982",
"30753824"
] | [] | 8.126459 | 4.386631 |
39776916 | 57 | Optimized BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21 robustly control multiple myeloma. | Challenges remain in reducing antigen escape and tumor recurrence while CAR-T cell therapy has substantially improved outcomes in the treatment of multiple myeloma. T cell receptor fusion construct (TRuC)-T cells, which utilize intact T cell receptor (TCR)-CD3 complex to eliminate tumor cells in a non-major histocompatibility complex (MHC)-restricted manner, represent a promising strategy. Moreover, interleukin-7 (IL-7) is known to enhance the proliferation and survival of T cells. C-C motif chemokine ligand 21 (CCL21) is a ligand for chemokine C-C motif receptor 7 (CCR7) and exhibits strong chemotaxis against naïve T cells and antigen-presenting cells such as dendritic cells.
The bispecific TRuC-T cells simultaneously targeting B cell maturation antigen (BCMA) and CD2 subset 1 (CS1) were constructed by pairing two of five subunits (i.e., TCRαC, TCRβC, CD3γ, CD3δ, and CD3ϵ) in the TCR/CD3 complex and were named C-AC-B-3E, C-BC-B-3E, C-3G-B-3E, C-3D-B-3E, C-3E-B-3E, B-3E-C-3E, B-3G-C-3E, and B-3D-C-3E. Additionally, the BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21, named BC-7×21 TRuC-T cells, were generated. All of the bispecific TRuC-T cells were characterized and tested
Following the optimization of various pairs of two subunits of TCR/CD3 complex, B-3G-C-3E TRuC-T cells, characterized by incorporating CD3γ and CD3ε, exhibited the strongest myeloma-specific cytotoxicity. Furthermore, the bispecific BC-7×21 TRuC-T cells had stronger proliferation, chemotaxis, and cytotoxicity
This study demonstrated that BC-7×21 TRuC-T cells, engineered through the optimization of the two subunits of TCR/CD3 complex and a co-expression cytokine strategy, may offer a novel and effective therapy for relapsed/refractory multiple myeloma. | [
-0.01755348965525627,
-0.004990398418158293,
0.04542393237352371,
0.03036411479115486,
-0.054078441113233566,
-0.01152711734175682,
0.028408294543623924,
0.05217151343822479,
0.008159439079463482,
-0.0012048160424456,
-0.0034838055726140738,
-0.02474112994968891,
-0.0216851606965065,
0.010261946357786655,
0.023909907788038254,
-0.030021846294403076,
0.04114557430148125,
-0.014179699122905731,
-0.001586048281751573,
0.04473939538002014,
0.005766614805907011,
0.018616966903209686,
0.010072476230561733,
-0.0020658355206251144,
-0.043908171355724335,
-0.006778141018003225,
-0.009290147572755814,
-0.006588670890778303,
-0.03285778686404228,
-0.019130369648337364,
0.029508443549275398,
-0.0389452762901783,
-0.018934788182377815,
-0.026721399277448654,
-0.0337379053235054,
0.03185542672872543,
0.0401432178914547,
0.03806515783071518,
-0.0027503727469593287,
0.0172723401337862,
0.04884662106633186,
0.01834804192185402,
0.01425304263830185,
0.0313175767660141,
-0.03148871287703514,
-0.018568072468042374,
-0.046719666570425034,
-0.020817264914512634,
0.006710909307003021,
-0.0028191320598125458,
0.00989522971212864,
0.021171757951378822,
-0.046206261962652206,
0.06410202383995056,
-0.05891909450292587,
0.0009030390647239983,
-0.03141536936163902,
0.031146442517638206,
0.00541212223470211,
0.003034577937796712,
0.0029383148066699505,
-0.004623682238161564,
0.019020356237888336,
-0.016575580462813377,
-0.03420241177082062,
0.006026372313499451,
-0.016392221674323082,
-0.019900474697351456,
-0.0044678277336061,
-0.024875594303011894,
-0.018372489139437675,
-0.03830963745713234,
0.011838826350867748,
0.016404446214437485,
0.04835766553878784,
0.0032026562839746475,
-0.005794118624180555,
0.053540587425231934,
-0.0022216900251805782,
-0.029899608343839645,
0.050900232046842575,
-0.033151160925626755,
0.03906751796603203,
-0.04816208407282829,
0.0047367531806230545,
0.01613551937043667,
0.018604744225740433,
-0.014020789414644241,
-0.052709367126226425,
0.006662013940513134,
-0.012957311235368252,
-0.004018600098788738,
-0.04635294899344444,
0.06542219966650009,
0.010255834087729454,
-0.011319311335682869,
0.004452547989785671,
-0.05994589999318123,
0.023433174937963486,
0.03725838288664818,
0.010799797251820564,
-0.0033371190074831247,
-0.0073404391296207905,
-0.004550338722765446,
0.03564482927322388,
-0.03205101191997528,
-0.020450549200177193,
0.00306666549295187,
0.01722344569861889,
0.02191741392016411,
0.06366196274757385,
0.006417536176741123,
-0.017162326723337173,
0.037087246775627136,
0.010500311851501465,
-0.0630263164639473,
-0.010457528755068779,
-0.023799892514944077,
-0.02180740050971508,
0.03263775631785393,
0.008086095564067364,
0.020047161728143692,
0.0357426218688488,
-0.0405588299036026,
-0.017443474382162094,
-0.03681832179427147,
0.10580989718437195,
-0.026330234482884407,
-0.06517772376537323,
-0.0509980209171772,
0.0393608883023262,
-0.015023146755993366,
0.01915481872856617,
0.013116221874952316,
-0.04187900945544243,
0.01597660966217518,
-0.004568674601614475,
-0.01110539399087429,
-0.05666990205645561,
-0.015194281004369259,
0.038603007793426514,
-0.009614081121981144,
-0.02706366777420044,
-0.008061648346483707,
-0.032906681299209595,
-0.05490966513752937,
-0.0012651714496314526,
0.007505461573600769,
-0.013482938520610332,
0.023885458707809448,
-0.059408050030469894,
0.03870080038905144,
0.02417883276939392,
-0.006038595922291279,
-0.014289714395999908,
-0.06879598647356033,
-0.01132542360574007,
0.07040954381227493,
-0.004269189666956663,
-0.08806082606315613,
-0.020206071436405182,
0.0050301263108849525,
-0.04994677007198334,
-0.011050386354327202,
0.05168255791068077,
0.012223878875374794,
0.0005202788161113858,
0.05799008160829544,
-0.0698716938495636,
0.014827565290033817,
0.018739206716418266,
-0.02681919001042843,
-0.10727676004171371,
-0.00843447633087635,
-0.06297742575407028,
0.002432551933452487,
0.02156292274594307,
-0.0021727944258600473,
-0.04547283053398132,
-0.011001490987837315,
0.010103035718202591,
-0.004483107477426529,
0.024875594303011894,
0.01281062513589859,
-0.022748637944459915,
-0.013177341781556606,
-0.004470883868634701,
0.0029505386482924223,
-0.018250251188874245,
0.015267624519765377,
-0.0044678277336061,
0.020096056163311005,
0.029337309300899506,
0.009980796836316586,
-0.013519610278308392,
-0.004519779235124588,
0.03136647120118141,
-0.0029474827460944653,
0.00676591694355011,
-0.01908147521317005,
0.01598883420228958,
-0.01032306533306837,
-0.013678519986569881,
0.014289714395999908,
-0.02718590572476387,
0.011197073385119438,
0.014485296793282032,
0.032539963722229004,
-0.03794291988015175,
0.007291543763130903,
0.05241599306464195,
0.029092831537127495,
-0.004192790482193232,
0.03544924780726433,
-0.02843274176120758,
-0.009167908690869808,
-0.01641666889190674,
0.0246922355145216,
0.0061822268180549145,
0.02799268253147602,
0.0017281508771702647,
-0.01774907112121582,
0.018079116940498352,
0.015475430525839329,
-0.018054669722914696,
0.020218295976519585,
0.006882043555378914,
-0.027088114991784096,
0.01453419215977192,
0.01618441566824913,
-0.00036232342245057225,
0.004033879842609167,
-0.002285865368321538,
-0.03217324987053871,
-0.02136733941733837,
-0.024631116539239883,
0.01799354888498783,
0.005989700555801392,
0.0530027374625206,
-0.02513229474425316,
-0.010347513481974602,
0.02485114522278309,
0.010310841724276543,
-0.014705326408147812,
0.005940805189311504,
0.006839259993284941,
-0.003578540636226535,
-0.07031174749135971,
-0.01822580397129059,
0.016881177201867104,
0.015891041606664658,
0.028163816779851913,
0.00025765644386410713,
0.0010657694656401873,
0.017162326723337173,
0.04454381391406059,
0.028848353773355484,
0.006735357455909252,
-0.01999826543033123,
-0.03231993690133095,
0.0010894532315433025,
-0.0036091001238673925,
-0.01606217585504055,
-0.026085756719112396,
-0.05094912648200989,
0.02655026502907276,
-0.009559073485434055,
0.015133162029087543,
0.0409499928355217,
-0.008520043455064297,
-0.003169040661305189,
-0.007639924064278603,
0.039849843829870224,
-0.009595745243132114,
-0.06092381104826927,
-0.0008900511893443763,
0.0010879251640290022,
0.0106408866122365,
0.007676595821976662,
-0.005980532616376877,
-0.0030024901498109102,
0.012040521018207073,
-0.0002376016491325572,
-0.037894025444984436,
-0.02437441423535347,
-0.012229991145431995,
-0.006338081322610378,
0.007297655567526817,
-0.009076230227947235,
-0.021954085677862167,
-0.004810096230357885,
-0.019460415467619896,
-0.028775010257959366,
-0.028090473264455795,
-0.05706106498837471,
0.022821981459856033,
-0.03618268296122551,
-0.03280889242887497,
-0.023995473980903625,
0.025914622470736504,
-0.030070742592215538,
0.0026097982190549374,
-0.03261330723762512,
-0.003544924780726433,
0.007010394707322121,
0.034471336752176285,
0.018616966903209686,
-0.06928494572639465,
0.03513142839074135,
0.05398064851760864,
0.009290147572755814,
-0.023873236030340195,
0.014191923663020134,
-0.0018091340316459537,
-0.0012231519212946296,
-0.04307694733142853,
0.01252947561442852,
-0.047648679465055466,
0.02108619175851345,
-0.051780350506305695,
0.002793156309053302,
-0.030339667573571205,
-0.034715816378593445,
0.044274888932704926,
-0.0025196471251547337,
-0.025352325290441513,
-0.022675294429063797,
-0.01895923539996147,
0.03151315823197365,
-0.043712589889764786,
0.06356416642665863,
-0.03904306888580322,
0.02071947418153286,
-0.02887280099093914,
-0.026403577998280525,
-0.006136387120932341,
-0.029581787064671516,
-0.016269981861114502,
0.016074400395154953,
0.035718172788619995,
-0.036720532923936844,
0.03994763642549515,
-0.04850435256958008,
0.00492927897721529,
0.019179265946149826,
0.032148800790309906,
0.016233311966061592,
0.009473506361246109,
0.0032118242233991623,
0.04931112751364708,
0.02224745973944664,
-0.02879945933818817,
0.045912887901067734,
-0.024044370278716087,
-0.005616872105747461,
0.020633907988667488,
-0.02344539947807789,
-0.009290147572755814,
-0.0007460386259481311,
0.013641849160194397,
0.020487220957875252,
0.012578370980918407,
-0.010812020860612392,
0.01771240122616291,
0.056718796491622925,
0.053149424493312836,
0.004366980865597725,
0.017846863716840744,
-0.01963154971599579,
-0.012553923763334751,
-0.03305336833000183,
0.013226237148046494,
0.03227103874087334,
0.0011253608390688896,
-0.020328311249613762,
0.0010833413107320666,
0.00472758524119854,
0.013837430626153946,
0.02662360854446888,
0.007817170582711697,
0.04554617404937744,
-0.04642629250884056,
-0.026159100234508514,
-0.07759718596935272,
-0.009595745243132114,
0.0016211919719353318,
0.030168533325195312,
-0.024790026247501373,
-0.05759891867637634,
0.02224745973944664,
-0.0033890705090016127,
-0.017076758667826653,
0.021941863000392914,
-0.01878810115158558,
-0.04075441136956215,
0.05285605043172836,
-0.003963592927902937,
0.05329611152410507,
0.05006900802254677,
0.025792384520173073,
0.008018864318728447,
-0.018849221989512444,
-0.023139802739024162,
-0.07060512155294418,
0.03461802378296852,
-0.01642889343202114,
0.04432378336787224,
0.0011765483068302274,
0.015756579115986824,
-0.029948502779006958,
-0.011135953478515148,
0.008825640194118023,
0.01625775918364525,
0.02148957923054695,
0.007108185440301895,
-0.023665430024266243,
-0.05393175408244133,
0.04099889099597931,
0.00029318209271878004,
0.020218295976519585,
-0.02024274319410324,
-0.03958091884851456,
0.0038199620321393013,
-0.015145385637879372,
0.008165551349520683,
-0.017736848443746567,
0.01706453412771225,
0.03295557573437691,
-0.008593386970460415,
-0.04564396291971207,
0.006081379484385252,
0.0710940808057785,
-0.0062769618816673756,
-0.0044800518080592155,
0.006521439179778099,
0.06913825869560242,
-0.0401432178914547,
0.004235574044287205,
-0.051584769040346146,
0.04312584549188614,
-0.03948312997817993,
-0.006228066049516201,
0.004159174859523773,
-0.03625602275133133,
0.01971711590886116,
0.0457906499505043,
0.022112997248768806,
-0.0025120070204138756,
-0.025987965986132622,
0.0285060852766037,
0.008788968436419964,
-0.014228594489395618,
-0.0053387791849672794,
0.02442331053316593,
-0.02762596681714058,
-0.0061302753165364265,
0.05026458948850632,
-0.049286678433418274,
0.008648394607007504,
0.006325857248157263,
0.05114470794796944,
-0.033028919249773026,
0.010048028081655502,
-0.03136647120118141,
-0.012095527723431587,
0.04156118631362915,
0.03192877024412155,
-0.014338609762489796,
0.025327876210212708,
-0.07021395862102509,
0.03075527958571911,
-0.039091963320970535,
-0.01653890870511532,
0.002777876565232873,
-0.013947445899248123,
0.02686808630824089,
0.030779726803302765,
0.01999826543033123,
0.054469604045152664,
0.023482071235775948,
-0.0002777112531475723,
-0.027968235313892365,
-0.009112901985645294,
-0.008287790231406689,
0.0014210259541869164,
0.019900474697351456,
-0.033395636826753616,
0.005277659744024277,
-0.02963068149983883,
0.03542480245232582,
-0.001914564985781908,
0.0005710843252018094,
0.007603252772241831,
-0.011936618015170097,
0.028579428791999817,
-0.00795163307338953,
0.025987965986132622,
0.0012720474041998386,
-0.036524951457977295,
0.0031201450619846582,
-0.019924921914935112,
0.04050993546843529,
0.012737281620502472,
0.04195235297083855,
0.02056056447327137,
0.033835697919130325,
0.003465469693765044,
0.044714950025081635,
-0.002464639488607645,
0.02574348822236061,
0.0071937525644898415,
-0.018726982176303864,
0.03075527958571911,
-0.027797101065516472,
-0.004849824123084545,
-0.02075614593923092,
-0.05050906911492348,
-0.019020356237888336,
-0.022174116224050522,
-0.0011177209671586752,
-0.010561431758105755,
-0.009277923963963985,
-0.009180133230984211,
-0.009345155209302902,
0.03393348678946495,
-0.032588861882686615,
-0.0154632069170475,
-0.04038769379258156,
-0.05779450014233589,
-0.07456566393375397,
0.020511668175458908,
-0.00849559623748064,
0.008526155725121498,
0.031024204567074776,
-0.011478221975266933,
-0.011423214338719845,
-0.019924921914935112,
0.018934788182377815,
-0.011692140251398087,
-0.0271125640720129,
0.003526589134708047,
-0.0027732925955206156,
0.02140401117503643,
0.009644640609622002,
0.024594444781541824,
0.025107847526669502,
0.005922469310462475,
-0.023225368931889534,
0.008862311951816082,
0.008960103616118431,
0.03755175694823265,
-0.02730814553797245,
0.007835506461560726,
0.004721472971141338,
0.007059290073812008,
-0.038089606910943985,
0.006955387070775032,
-0.02662360854446888,
0.011025939136743546,
-0.03760065138339996,
-0.007303767371922731,
-0.01991269923746586,
-0.004642018117010593,
-0.004345588851720095,
0.007762162946164608,
0.017577936872839928,
-0.0006665833643637598,
0.008898983709514141,
-0.02787044458091259,
0.05207372456789017,
-0.010549207217991352,
0.01518205739557743,
-0.012009960599243641,
-0.008324461057782173,
0.022271906957030296,
0.0035388129763305187,
-0.006078323815017939,
-0.002061251550912857,
-0.03156205639243126,
0.017370130866765976,
-0.03554704040288925,
-0.019692668691277504,
-0.009094566106796265,
0.054078441113233566,
-0.027894891798496246,
0.0025807663332670927,
-0.046401843428611755,
0.0006669653812423348,
-0.007829394191503525,
0.024435533210635185,
0.021025070920586586,
-0.008000528439879417,
0.018482504412531853,
0.005152364727109671,
-0.022259682416915894,
0.030144084244966507,
0.002171266358345747,
0.006833148188889027,
-0.042465753853321075,
0.00935737881809473,
0.020487220957875252,
-0.012859520502388477,
-0.02316424995660782,
-0.035400353372097015,
-0.017296789214015007,
0.040412142872810364,
0.03762510046362877,
-0.0018641415517777205,
-0.03217324987053871,
0.012480580247938633,
0.04994677007198334,
0.03645160794258118,
-0.013238460756838322,
0.009057894349098206,
0.03904306888580322,
-0.00565354386344552,
-0.012578370980918407,
-0.008862311951816082,
0.02296866849064827,
-0.008843976072967052,
-0.0021743224933743477,
-0.0014416537014767528,
0.010231386870145798,
0.013751863501966,
0.007004282437264919,
-0.05530082806944847,
-0.02625689096748829,
-0.008782857097685337,
0.028579428791999817,
0.0004694733361247927,
-0.02625689096748829,
-0.009993021376430988,
-0.022100772708654404,
0.02043832466006279,
-0.019423743709921837,
-0.02284642867743969,
0.036402709782123566,
0.00016234838403761387,
0.006069155875593424,
-0.00171898293774575,
-0.014558639377355576,
0.04285692051053047,
-0.009229028597474098,
-0.007065401878207922,
0.009534625336527824,
-0.005161532666534185,
-0.003282111370936036,
0.021330667659640312,
-0.007493237499147654,
-0.023640980944037437,
-0.035033635795116425,
-0.008324461057782173,
0.031586501747369766,
-0.012095527723431587,
0.024227727204561234,
-0.008238893933594227,
-0.026012413203716278,
0.0028573316521942616,
0.05750112608075142,
0.05280715599656105,
-0.04444602504372597,
0.02188074216246605,
-0.014693101868033409,
-0.025034504011273384,
-0.031708743423223495,
-0.0015020091086626053,
-0.014925356023013592,
0.011209296993911266,
-0.007823282852768898,
0.028090473264455795,
0.06737802177667618,
0.0001690333301667124,
0.042147934436798096,
0.020633907988667488,
0.0013614344643428922,
0.030021846294403076,
0.006882043555378914,
0.008520043455064297,
-0.03882303833961487,
0.019167041406035423,
-0.02205187827348709,
-0.015536550432443619,
-0.03261330723762512,
-0.07036064565181732,
0.005589368753135204,
0.011698251590132713,
-0.030413011088967323,
-0.006252514198422432,
0.006466432008892298,
0.004642018117010593,
0.013922997750341892,
-0.010463640093803406,
0.022589728236198425,
0.0011054970091208816,
-0.0012292638421058655,
-0.033273398876190186,
-0.007163193076848984,
-0.0062402901239693165,
-0.02252860926091671,
-0.03469136729836464,
0.035595934838056564,
0.0024142160546034575,
0.0034104622900485992,
-0.014888684265315533,
0.021171757951378822,
-0.02345762401819229,
-0.03806515783071518,
0.003529645036906004,
0.01979045942425728,
0.03960536792874336,
-0.0076277004554867744,
0.0053387791849672794,
-0.013702968135476112,
-0.06507992744445801,
0.002968874527141452,
0.021856294944882393,
-0.005827734246850014,
0.05285605043172836,
0.024313295260071754,
0.01540208701044321,
0.016758937388658524,
0.007529909256845713,
-0.01859251968562603,
-0.027577070519328117,
0.06175503507256508,
0.033835697919130325,
-0.036647189408540726,
0.03481360524892807,
-0.002472279593348503,
0.017284564673900604,
-0.0034624135587364435,
-0.016648922115564346,
-0.035473696887493134,
-0.0038169061299413443,
-0.018384713679552078,
0.024631116539239883,
-0.013727416284382343,
-0.05173145607113838,
0.00437614880502224,
-0.011875498108565807,
0.02630578726530075,
-0.03750285878777504,
-0.039898741990327835,
0.02606130950152874,
0.004400596488267183,
0.030853070318698883,
0.03711169585585594,
0.03879859298467636,
-0.0010802852921187878,
0.0028435797430574894,
-0.01694229617714882,
0.009008998982608318,
-0.028359398245811462,
-0.005858293734490871,
-0.0066497898660600185,
-0.041976798325777054,
-0.0014317218447104096,
-0.011209296993911266,
-0.00897232722491026,
-0.0057788388803601265,
-0.012248327024281025,
-0.020536117255687714,
-0.014081908389925957,
0.006301409564912319,
-0.03024187684059143,
0.016049953177571297,
0.005626040045171976,
0.014301938004791737,
-0.007364886812865734,
0.02108619175851345,
-0.021257326006889343,
-0.0271125640720129,
-0.0073465509340167046,
-0.014106356538832188,
0.006619230378419161,
0.010744789615273476,
-0.0216851606965065,
-0.0005034710047766566,
0.0032607195898890495,
0.012663938105106354,
-0.018726982176303864,
0.020902832970023155,
-0.004831488244235516,
0.004321141168475151,
-0.023946577683091164,
0.004146950785070658,
0.007939409464597702,
0.019778236746788025,
-0.014411953277885914,
-0.03217324987053871,
-0.008318349719047546,
0.04393262043595314,
-0.014338609762489796,
0.009565184824168682,
-0.01427749078720808,
0.025963518768548965,
0.03031522035598755,
-0.11959843337535858,
-0.023506518453359604,
-0.010433080606162548,
-0.02437441423535347,
-0.011093170382082462,
-0.004626737907528877,
-0.01799354888498783,
0.0025456228759139776,
-0.015536550432443619,
-0.020988399162888527,
-0.013580729253590107,
-0.02417883276939392,
0.00016187089204322547,
-0.024276623502373695,
0.030510801821947098,
0.0168689526617527,
0.002197242109104991,
-0.04759978502988815,
0.0068270363844931126,
0.02497338503599167,
0.012602819129824638,
0.01449752040207386,
0.009962460957467556,
0.015548774041235447,
-0.01880032569169998,
0.01284729689359665,
-0.002673973562195897,
-0.0018014941597357392,
-0.047330860048532486,
-0.025670144706964493,
0.016917848959565163,
0.042783576995134354,
-0.023702101781964302,
0.0381385013461113,
0.011679916642606258,
-0.01996159367263317,
0.007199864834547043,
-0.007676595821976662,
-0.008220558054745197,
0.008385580964386463,
0.002478391397744417,
0.0021483467426151037,
0.009222916327416897,
-0.006157779134809971,
-0.04050993546843529,
-0.03400683030486107,
-0.028139369562268257,
0.010457528755068779,
0.01839693821966648,
-0.022540831938385963,
0.030095189809799194,
-0.016208862885832787,
-0.026696952059864998,
0.013861878775060177,
-0.006102771498262882,
-0.03295557573437691,
-0.010530871339142323,
0.01425304263830185,
0.0397520549595356,
0.010897587984800339,
-0.022271906957030296,
0.02894614450633526,
0.034153517335653305,
-0.005094301421195269,
-0.007835506461560726,
-0.011148177087306976,
-0.03794291988015175,
0.04581509903073311,
-0.037038352340459824,
0.0023210090585052967,
-0.014057460241019726,
0.01782241463661194,
-0.049091096967458725,
-0.002029163995757699,
0.008740073069930077,
-0.039409786462783813,
-0.016331102699041367,
0.0032423839438706636,
-0.00284663587808609,
0.018299147486686707,
0.006863708142191172,
-0.016673371195793152,
-0.00040491597610525787,
0.035400353372097015,
-0.0096385283395648,
-0.018458057194948196,
-0.014521967619657516,
0.019057027995586395,
0.01811578869819641,
0.001035973778925836,
-0.017040086910128593,
0.0082327825948596,
-0.0017143989680334926,
-0.003581596538424492,
0.011710476130247116,
-0.018580295145511627,
-0.039091963320970535,
-0.009626304730772972,
-0.007322103250771761,
0.001397342188283801,
0.032466623932123184,
-0.0005260087782517076,
-0.003172096563503146,
-0.04554617404937744,
-0.015671012923121452,
-0.004901775624603033,
0.02919062227010727,
-0.007982192561030388,
0.0054549057967960835,
-0.008458924479782581,
-0.007187640760093927,
-0.012932864017784595,
0.009002886712551117,
-0.01593993790447712,
0.017137877643108368,
-0.00626473780721426,
0.04388372600078583,
0.0015936881536617875,
0.017565714195370674,
-0.0023851844016462564,
0.07045843452215195,
0.05569199100136757,
0.009406275115907192,
-0.031024204567074776,
-0.009986909106373787,
0.015059818513691425,
0.03298002481460571,
0.030046293511986732,
-0.00009760003013070673,
0.0008571994840167463,
0.001767878420650959,
0.029777368530631065,
-0.020743923261761665,
-0.007578805088996887,
-0.015756579115986824,
0.0299240555614233,
-0.014607534743845463,
0.035473696887493134,
0.013654072768986225,
0.03980094939470291,
-0.0004629793984349817,
-0.0003481895546428859,
-0.0066436780616641045,
-0.05324721708893776,
0.008978438563644886,
-0.029972949996590614,
-0.059456948190927505,
0.048210978507995605,
0.01088536437600851,
0.0004297457344364375,
-0.0020826433319598436,
0.028383847326040268,
-0.006215842440724373,
0.04454381391406059,
0.012101639993488789,
0.01327513251453638,
0.012920639477670193,
-0.033957935869693756,
-0.005681047681719065,
0.027088114991784096,
-0.05481187254190445,
0.06952942162752151,
-0.0299240555614233,
-0.04114557430148125,
0.021892966702580452,
-0.022919772192835808,
-0.018947012722492218,
0.01443640049546957,
0.017052311450242996,
0.03420241177082062,
0.014204147271811962,
-0.06679127365350723,
0.056278739124536514,
-0.0051462529227137566,
-0.04561951756477356,
0.0025761823635548353,
0.0035143650602549314,
0.0089356554672122,
0.028970593586564064,
0.025352325290441513,
0.003627436002716422,
-0.0035663165617734194,
0.01327513251453638,
0.007383222691714764,
0.01614774391055107,
-0.02256528101861477,
0.002933730836957693,
-0.02147735469043255,
0.03124423511326313,
-0.0010237498208880424,
-0.02461889199912548,
-0.012883968651294708,
0.0008671313989907503,
0.05143808200955391,
0.029948502779006958,
-0.018017997965216637,
-0.030413011088967323,
0.033028919249773026,
-0.050215695053339005,
-0.0341290682554245,
-0.009076230227947235,
0.033835697919130325,
0.00715708127245307,
-0.01186327449977398,
-0.009064005687832832,
0.01397189311683178,
0.030070742592215538,
-0.03791847079992294,
-0.018213579431176186,
0.04092554748058319,
0.024068817496299744,
0.03442244231700897,
-0.04794205352663994,
0.0349358469247818,
0.010763125494122505,
-0.00319654424674809,
0.016758937388658524,
-0.03219769522547722,
-0.035082533955574036,
-0.010683669708669186,
-0.025792384520173073,
-0.01493757963180542,
-0.005103469360619783,
-0.016722265630960464,
0.026330234482884407,
-0.016758937388658524,
0.03197766840457916,
0.0024264398962259293,
-0.008703401312232018,
0.016196640208363533,
-0.024313295260071754,
0.054958559572696686,
0.01722344569861889,
0.0077743870206177235,
0.005390730686485767,
0.014155251905322075,
0.020022712647914886,
-0.04354145750403404,
-0.002703005215153098,
-0.024117713794112206,
0.05251378193497658,
0.019289281219244003,
-0.011441550217568874,
-0.013825207017362118,
-0.025352325290441513,
0.01971711590886116,
0.05481187254190445,
-0.03168429434299469,
0.0005378506612032652,
-0.017247892916202545,
0.005311275366693735,
0.00674758106470108,
0.002999434247612953,
0.04823542758822441,
0.02525453455746174,
0.018482504412531853,
0.010231386870145798,
0.023103130981326103,
0.05442070960998535,
0.012052744626998901,
-0.0012040520086884499,
-0.016575580462813377,
0.007615476381033659,
0.008281677961349487,
0.00023798363690730184,
-0.0010871612466871738,
-0.018885891884565353,
-0.017198996618390083,
-0.01325068436563015,
0.016807833686470985,
0.020328311249613762,
0.004070551600307226,
-0.013055102899670601,
-0.0068270363844931126,
0.01309177465736866,
-0.027650414034724236,
0.019044803455471992,
-0.03236883133649826,
-0.004822320304811001,
0.0061516668647527695,
-0.03019298054277897,
0.0023210090585052967,
-0.02043832466006279,
0.030461905524134636,
0.023518742993474007,
0.009149573743343353,
-0.0025700705591589212,
-0.027357039973139763,
0.025841278955340385,
-0.033273398876190186,
0.0010466696694493294,
-0.010909811593592167,
-0.004403652157634497,
-0.004104167222976685,
-0.004125559236854315,
-0.0206828024238348,
-0.010671446099877357,
-0.03706280142068863,
-0.0075971405021846294,
-0.01138654351234436,
-0.0011712004197761416,
0.028334951028227806,
-0.031268682330846786,
-0.03364011272788048,
-0.000882411259226501,
-0.022259682416915894,
-0.016514459624886513,
-0.016734490171074867,
0.0509980209171772,
0.0060416520573198795,
-0.03830963745713234,
0.004003320354968309,
0.013446266762912273,
-0.002754956716671586,
0.010176379233598709,
-0.01878810115158558,
-0.007291543763130903,
0.032344382256269455,
-0.011429326608777046,
-0.012553923763334751,
0.0038963614497333765,
0.02112286351621151,
0.01377631165087223,
-0.015952162444591522,
-0.017810191959142685,
-0.02075614593923092,
0.020206071436405182,
-0.021856294944882393,
0.0015967441722750664,
-0.013079550117254257,
-0.0018671974539756775,
-0.01706453412771225,
0.01371519174426794,
-0.014790893532335758,
0.013360699638724327,
0.03730727732181549,
0.007010394707322121,
-0.0026968931779265404,
0.007120409514755011,
-0.0047367531806230545,
-0.010983155108988285,
-0.015169833786785603,
0.018445832654833794,
0.0018060781294479966,
0.019093697890639305,
0.002009300049394369,
0.016685593873262405,
0.009687423706054688,
0.006029428448528051,
-0.022223012521862984,
0.06195061653852463,
-0.010078588500618935,
-0.03879859298467636,
0.036476053297519684,
-0.021954085677862167,
-0.003282111370936036,
-0.016318878158926964,
0.04530169442296028,
-0.0023622645530849695,
-0.023188699036836624,
-0.020413877442479134,
0.030413011088967323,
0.041218917816877365,
-0.006108883302658796,
0.019729340448975563,
0.013654072768986225,
-0.04293026402592659,
-0.002018467988818884,
0.012773953378200531,
-0.0005672643892467022,
0.012248327024281025,
0.01088536437600851,
0.0006551234982907772,
0.0013476826716214418,
-0.013666296377778053,
0.005155420862138271,
0.054029542952775955,
0.006344193127006292,
0.005271547939628363,
0.04381038248538971,
0.004748976789414883,
0.016269981861114502,
-0.003275999566540122,
-0.034031279385089874,
-0.0000051897768571507186,
-0.029410652816295624,
-0.05979921668767929,
-0.040338799357414246,
0.01818913221359253,
-0.024716682732105255,
0.014485296793282032,
-0.007548245135694742,
0.03112199530005455,
0.02943510003387928,
-0.021660713478922844,
0.016392221674323082,
-0.00020895192574243993,
0.03207545727491379,
-0.020462773740291595,
0.019215937703847885,
-0.02630578726530075,
-0.0015577805461362004,
0.021868519484996796,
0.0024340797681361437,
-0.013617401011288166,
0.024875594303011894,
0.00887453556060791,
0.02593907155096531,
0.013385146856307983,
0.01543875876814127,
-0.017333460971713066,
0.01625775918364525,
-0.044397126883268356,
0.014790893532335758,
-0.037209488451480865,
0.003465469693765044,
-0.008037200197577477,
-0.018531400710344315,
-0.022980893030762672,
-0.000765138422138989,
0.01431416254490614,
-0.003048329846933484,
0.010616438463330269,
0.016477787867188454,
-0.02205187827348709,
0.0006524495547637343,
0.02337205596268177,
0.01082424446940422,
-0.020939504727721214,
0.015035371296107769,
0.01226666197180748,
0.014069684781134129,
0.00554047292098403,
-0.009589632973074913,
-0.04288136586546898,
0.005085133481770754,
-0.02196631021797657,
0.007829394191503525,
-0.04349255934357643,
0.012034408748149872,
0.004122503101825714,
-0.004027768038213253,
0.036158233880996704,
0.009369603358209133,
0.012981759384274483,
-0.010127483867108822,
-0.01862919144332409,
-0.014045236632227898,
0.016013281419873238,
-0.023200921714305878,
0.01625775918364525,
0.00009292057802667841,
-0.015328744426369667,
0.010536983609199524,
-0.046524081379175186,
-0.019167041406035423,
-0.032588861882686615,
-0.007028730120509863,
-0.0021636264864355326,
0.036720532923936844,
-0.022418593987822533,
-0.004895663354545832,
-0.006704797502607107,
0.017370130866765976,
0.00847114808857441,
0.007866065949201584,
-0.011838826350867748,
-0.016404446214437485,
0.008049423806369305,
0.021746279671788216,
0.0065336632542312145,
0.0009229028364643455,
0.03376235440373421,
0.00967520009726286,
0.020976176485419273,
-0.03779623284935951,
0.004073607735335827,
0.005616872105747461,
0.004593122284859419,
-0.0381385013461113,
-0.030901964753866196,
0.017162326723337173,
0.020890608429908752,
-0.005045406054705381,
0.01057976670563221,
0.008067759685218334,
-0.023420952260494232,
-0.02574348822236061,
0.01658780314028263,
0.008758408948779106,
-0.026574712246656418,
-0.011655468493700027,
-0.013886325992643833,
-0.008795080706477165,
-0.0001769597438396886,
0.0036152121610939503,
-0.009180133230984211,
-0.027845995500683784,
-0.01018249150365591,
-0.006955387070775032,
0.013544057495892048,
-0.02867721952497959,
0.014008564874529839,
-0.04241685941815376,
-0.002003188244998455,
-0.0027534286491572857,
-0.05481187254190445,
-0.04405485838651657,
0.0008510875632055104,
0.01750459522008896,
-0.02196631021797657,
0.005112637300044298,
-0.0032668316271156073,
0.014790893532335758,
0.06693796068429947,
-0.02159959450364113,
-0.006625342182815075,
0.043150290846824646,
0.0011047330917790532,
-0.020267190411686897,
0.01403301302343607,
0.03376235440373421,
0.014668654650449753,
-0.02818826399743557,
-0.04244130849838257,
-0.01327513251453638,
0.01229111012071371,
0.024276623502373695,
0.00507902167737484,
0.011924393475055695,
0.020585011690855026,
-0.006350304931402206,
0.019655996933579445,
0.010304729454219341,
-0.011380431242287159,
0.010830356739461422,
-0.002360736485570669,
0.008568938821554184,
-0.0010596575448289514,
-0.0013148309662938118,
-0.0038963614497333765,
0.03119533881545067,
0.02980181574821472,
0.005418234504759312,
0.00247533549554646,
0.01867808774113655,
0.025205638259649277,
-0.00004526655175141059,
-0.0030330498702824116,
0.03400683030486107,
0.027137011289596558,
-0.025792384520173073,
-0.0043608685955405235,
0.02104952000081539,
-0.019411519169807434,
-0.04654853045940399,
-0.009259588085114956,
0.011050386354327202,
0.000977146322838962,
0.005677991546690464,
0.04060772433876991,
0.017370130866765976,
-0.0029902663081884384,
0.02461889199912548,
-0.009125125594437122,
-0.019741564989089966,
-0.014069684781134129,
0.024521101266145706,
-0.06762249767780304,
0.0029887384735047817,
-0.027210354804992676,
-0.018238026648759842,
-0.015964385122060776,
-0.009143461473286152,
-0.013959669508039951,
-0.0016196639044210315,
-0.005259323865175247,
0.00484065618366003,
-0.010818133130669594,
-0.012083304114639759,
-0.02593907155096531,
0.021514026448130608,
-0.02662360854446888,
0.02919062227010727,
0.020206071436405182,
-0.020707251504063606,
-0.037160590291023254,
-0.004146950785070658,
-0.013018431141972542,
-0.0014340138295665383,
-0.03273554891347885,
-0.00444643571972847,
0.01678338646888733,
0.0012170398840680718,
0.016159968450665474,
0.01637999713420868,
0.013152893632650375,
-0.0010168738663196564,
-0.03505808487534523,
0.0022293298970907927,
-0.020108280703425407,
0.023824339732527733,
0.008159439079463482,
-0.005522137042135,
-0.009363491088151932,
-0.010750900954008102,
-0.0011925922008231282,
-0.0413656048476696,
-0.006014148239046335,
-0.019020356237888336,
-0.03557148575782776,
0.004201958421617746,
-0.021452907472848892,
-0.02240636944770813,
-0.009803551249206066,
0.019228162243962288,
-0.05285605043172836,
0.009271811693906784,
-0.0017862142994999886,
0.00937571469694376,
0.019325952976942062,
0.029092831537127495,
-0.014130803756415844,
0.0032668316271156073,
-0.015573221258819103,
0.04249020293354988,
-0.014986474998295307,
-0.0009435306419618428,
0.03019298054277897,
-0.013446266762912273,
-0.017052311450242996,
0.01803022064268589,
0.01212608814239502,
-0.010292505845427513,
-0.0003835241950582713,
-0.021147310733795166,
-0.011276528239250183,
0.0059835887514054775,
-0.01915481872856617,
0.028090473264455795,
-0.00319654424674809,
0.03031522035598755,
0.01919149048626423,
0.008067759685218334,
-0.023188699036836624,
0.0011375846806913614,
-0.032222144305706024,
-0.012498916126787663,
0.000895399134606123,
0.0010925091337412596,
-0.01983935572206974,
0.012700609862804413,
0.0049934545531868935,
0.0020276359282433987,
0.03288223221898079,
0.017198996618390083,
-0.006472543813288212,
0.02975292131304741,
-0.019986042752861977,
-0.007242648396641016,
0.018726982176303864,
-0.013201788999140263,
0.006484767887741327,
0.004810096230357885,
-0.0014867292484268546,
0.007022618316113949,
0.05006900802254677,
0.03011963702738285,
-0.03760065138339996,
0.013470714911818504,
-0.01042085699737072,
0.007071513682603836,
-0.010445304214954376,
0.0008908151648938656,
0.0939771831035614,
-0.013727416284382343,
0.026721399277448654,
0.01399634126573801,
-0.018519176170229912,
-0.005054573994129896,
0.007676595821976662,
-0.005512969568371773,
0.008465035818517208,
-0.023078683763742447,
0.021073967218399048,
0.03579151630401611,
0.05794118717312813,
0.02056056447327137,
0.030461905524134636,
-0.014363057911396027,
0.00012433977099135518,
0.023506518453359604,
0.00028076721355319023,
0.00985855795443058,
-0.010714230127632618,
0.038211844861507416,
-0.0006024080212228,
0.019057027995586395,
0.006423648446798325,
-0.012401125393807888,
-0.014485296793282032,
-0.009039558470249176,
0.02699032425880432,
-0.014790893532335758,
0.026770293712615967,
0.017211221158504486,
0.006998170632869005,
-0.04060772433876991,
0.007120409514755011,
0.012205542996525764,
-0.008293901570141315,
-0.010812020860612392,
-0.005351002793759108,
0.004834543913602829,
0.004926223307847977,
0.002204882213845849,
0.02894614450633526,
-0.008324461057782173,
-0.001598272123374045,
0.019643772393465042,
-0.011557677760720253,
0.005613816436380148,
0.023640980944037437,
-0.02124510146677494,
0.003279055468738079,
0.0010367376962676644,
0.017480146139860153,
-0.014803117141127586,
-0.02305423468351364,
-0.016636699438095093,
0.022235235199332237,
-0.005002622492611408,
-0.004697025287896395,
-0.03887193277478218,
-0.030461905524134636,
0.00965686421841383,
0.018091341480612755,
-0.010787572711706161,
0.010219162330031395
] | 2025-01-08 | 65 | 39776916 | [
"T cells",
"intact T cell receptor",
"T cell receptor fusion construct",
"tumor cells",
"TRuC)-T cells",
"B cell maturation antigen",
"dendritic cells",
"naïve T cells",
"BC-7×21 TRuC-T cells",
"CAR-T cell therapy",
"TCR)-CD3 complex",
"strong chemotaxis",
"stronger proliferation",
"the bispecific BC-7×21 TRuC-T cells",
"antigen-presenting cells",
"The bispecific TRuC-T cells",
"the bispecific TRuC-T cells",
"multiple myeloma",
"the BCMA/CS1 bispecific TRuC-T cells",
"TCR/CD3 complex, B-3G-C-3E TRuC-T cells",
"TCR",
"TCR/CD3 complex",
"chemokine C-C motif receptor",
"a non-major histocompatibility complex",
"MHC)-restricted manner",
"chemotaxis",
"BCMA",
"CD3γ",
"various pairs",
"a co-expression cytokine strategy"
] | [
"B cell maturation antigen",
"C-C motif chemokine ligand 21",
"CD2 subset 1",
"T cell receptor fusion construct T cell",
"interleukin-7",
"multiple myeloma"
] | 0 | 10.3389/fimmu.2024.1502936
10.1016/S0753-3322(02)00194-4
10.1002/ijc.22718
10.1016/j.clml.2015.07.641
10.1073/pnas.86.24.10024
10.1158/0008-5472.CAN-11-3890
10.1016/j.cell.2018.03.038
10.1126/scitranslmed.3008226
10.1177/2515135520927164
10.1002/jha2.338
10.1056/NEJMoa2024850
10.1186/s13045-018-0681-6
10.1126/sciadv.adf3700
10.1016/S0092-8674(02)01194-7
10.1084/jem.20042155
10.1038/s41467-019-10097-0
10.1080/2162402X.2023.2182058
10.1158/1078-0432.CCR-12-2422
10.1089/hum.2018.001
10.1182/blood-2004-11-4512
10.1038/s41375-020-0734-z
10.1200/JCO.2018.77.8084
10.1038/s41591-021-01245-5
10.1182/blood-2020-139040
10.1182/blood-2019-129088
10.3390/cancers12092523
10.1080/1744666X.2016.1209112
10.1016/s1471-4906(01)02028-2
10.1016/j.it.2005.01.004
10.1016/j.cytogfr.2005.05.004
10.1073/pnas.95.1.258
10.1002/(SICI)1521-4141(199806)28:06<2025::AID-IMMU2025>3.0.CO;2-C
10.3389/fimmu.2021.609421
10.1073/pnas.0907448106
10.1158/1078-0432.CCR-07-4246
10.4049/jimmunol.167.10.5517
10.3390/ijms221910828
10.1097/TP.0000000000003851
10.1038/s41422-023-00789-0
10.1073/pnas.1716266115
10.4049/jimmunol.1700236
10.1158/2159-8290.CD-19-0945
10.1038/s41591-018-0290-5
10.1038/nm.3838
10.1016/j.omto.2022.04.003
10.1038/s41591-023-02452-y
10.1146/annurev.iy.06.040188.003213
10.1038/s41408-021-00459-7
10.1016/j.blre.2018.11.002
10.1016/j.cell.2020.07.018
10.1080/14712598.2016.1221920
10.1182/blood-2014-01-545020
10.1038/s41467-021-21177-5
10.1038/s41571-018-0142-8
10.1038/s41375-019-0669-4
10.1007/978-1-4615-0757-4_11
10.21873/anticanres.11405
10.1038/nri1052
10.1038/s41421-023-00625-0
10.1016/j.cell.2019.07.028
10.1038/ni.2085
10.1016/j.it.2007.04.002
10.1084/jem.181.5.1653
10.1002/ajh.26586 | [
"Li",
"Zheng",
"Liu",
"Zhang",
"Zhu",
"Xin",
"Zhao",
"Chen",
"Zheng",
"Zhao",
"Gao"
] | [
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.\nYicheng County People's Hospital, Linfen, Shanxi, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.\nNingbo Hangzhou Bay Hospital, Ningbo, Zhejiang, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.\nTaizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.\nTaizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.",
"Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, Zhejiang, China.",
"Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, China.\nZhejiang Qixin Biotech, Wenzhou, Zhejiang, China."
] | [
"39776916",
"12199621",
"17405120",
"26361647",
"2784887",
"2513569",
"22315351",
"29706540",
"24553386",
"32524070",
"35844299",
"33626253",
"30572922",
"36791198",
"12507424",
"16087711",
"31064990",
"36875551",
"23344265",
"29641319",
"15827134",
"32055000",
"29812997",
"33619368",
"33558511",
"32899464",
"27376202",
"11574281",
"15745860",
"15996891",
"9419363",
"9645384",
"33767695",
"19805141",
"18451245",
"11698418",
"34639168",
"34115657",
"36882513",
"29440406",
"29288199",
"32193224",
"30559421",
"25939063",
"35572194",
"37501016",
"3289580",
"33824268",
"30528964",
"32730808",
"27533882",
"24970931",
"33558511",
"30523282",
"31780814",
"10390077",
"12405190",
"28314253",
"12669018",
"38191529",
"31442409",
"21841786",
"17462953",
"7722445",
"35491511"
] | [] | 5.196897 | 6.090935 |
39776055 | 58 | Immunotherapy on ICU: a narrative review. | Patients with cancer account for 15% of all admissions to critical care and so an understanding of the pathophysiology and anticipated complications of specialist treatment is essential for the intensive care clinician. The development of chimeric antigen receptor T-cell therapy for haematological malignancies and immune checkpoint inhibitors for solid organ tumours has led to significant improvements in the prognosis of those patients whose tumours respond. This review is intended to provide the non-specialist with an understanding of the current concepts in pathophysiology, diagnosis and management of complications due to chimeric antigen receptor T-cell therapy and immune checkpoint inhibitors for malignant disease.
We performed searches of electronic databases to identify relevant peer-reviewed publications in the literature. Basic science; clinical trials; cohort studies; systematic reviews; meta-analyses; and guidelines were eligible for inclusion. Abstracts were screened to identify publications relevant to immune effector cell toxicities of chimeric antigen receptor T-cell therapy and immune-related adverse events of immune checkpoint inhibitors.
While the pathophysiology for toxicities due to chimeric antigen receptor T-cells and immune checkpoint inhibitors remains incompletely understood, targeted drug therapies have been successfully implemented for toxicities such as cytokine release syndrome. Corticosteroids remain an important component of pharmacological management. The diagnosis of toxicities remains largely clinical, and a high index of suspicion should remain for infective complications. Management of toxicities should be undertaken in conjunction with the patient's primary oncologist.
Despite significant advances in the development of targeted immunotherapy, the mechanism of action for the resultant toxicities remains poorly understood and limits the development of predictive models, diagnostic biomarkers and highly effective treatment options. Further research is needed to identify treatment regimens which minimise the use of corticosteroids in chimeric antigen receptor T-cell and immune checkpoint inhibitor-associated toxicities. | [
0.012262379750609398,
0.033444926142692566,
0.04754381254315376,
0.03839550539851189,
-0.024479132145643234,
-0.002324148779734969,
0.043939244002103806,
0.011509526520967484,
0.017384061589837074,
0.027513358741998672,
-0.02100003883242607,
-0.03260082006454468,
-0.043277643620967865,
0.024479132145643234,
0.017315620556473732,
-0.03166545554995537,
0.039262428879737854,
0.023281410336494446,
0.03273770213127136,
0.056897442787885666,
0.03422059491276741,
0.017475316300988197,
0.038669273257255554,
-0.019665434956550598,
-0.04583278298377991,
0.0007549918373115361,
-0.0027975335251539946,
-0.029657848179340363,
-0.011230058036744595,
0.008429673500359058,
0.030570397153496742,
-0.019003836438059807,
0.00515019940212369,
0.016688242554664612,
-0.031209181994199753,
0.03659322112798691,
-0.004043733701109886,
0.03935368359088898,
-0.01666542887687683,
0.008971499279141426,
0.05767310783267021,
0.025482935830950737,
-0.020144524052739143,
0.07939177751541138,
-0.09102678298950195,
-0.040494371205568314,
0.009901158511638641,
-0.05644116550683975,
0.011001921258866787,
-0.03980995714664459,
-0.029110318049788475,
-0.009302298538386822,
-0.008212942630052567,
0.04038030281662941,
-0.0286084171384573,
0.045422136783599854,
-0.01063690148293972,
0.03166545554995537,
-0.008281383663415909,
-0.050418343394994736,
0.0104829091578722,
-0.011144506745040417,
0.016391664743423462,
-0.014726262539625168,
-0.07606097310781479,
-0.022893577814102173,
-0.018308017402887344,
-0.033422112464904785,
-0.0006894023972563446,
-0.029110318049788475,
0.031893592327833176,
0.005557994823902845,
0.010859334841370583,
0.011498119682073593,
-0.011315610259771347,
-0.005914459470659494,
-0.006507616490125656,
0.05707995221018791,
0.011344127357006073,
-0.01760079152882099,
0.013802306726574898,
0.020760493353009224,
0.026874573901295662,
-0.021479126065969467,
-0.014669228345155716,
0.031893592327833176,
-0.015524743124842644,
-0.007477199658751488,
-0.07542219012975693,
-0.015901168808341026,
-0.01602664589881897,
0.030387887731194496,
-0.0338783897459507,
0.04437270388007164,
-0.0017509537283331156,
-0.012627399526536465,
0.005261416547000408,
-0.022368861362338066,
0.02988598495721817,
0.026760505512356758,
0.03244112432003021,
-0.006245258264243603,
-0.04533088207244873,
-0.018387865275144577,
0.03937649726867676,
-0.030570397153496742,
-0.03082134947180748,
-0.014760483056306839,
0.028152141720056534,
-0.014977212995290756,
0.05183279514312744,
0.01570725254714489,
-0.035270024091005325,
0.06406095623970032,
-0.036479152739048004,
-0.042387910187244415,
-0.0572168342769146,
-0.01169203594326973,
-0.014030443504452705,
0.0645628571510315,
-0.035224396735429764,
0.03600006550550461,
-0.006245258264243603,
0.0049733929336071014,
0.01667683571577072,
-0.038988664746284485,
0.04772632196545601,
-0.03892022371292114,
-0.04218258708715439,
-0.087422214448452,
0.06387843936681747,
-0.017737675458192825,
-0.004842214286327362,
-0.04320920258760452,
-0.03666166216135025,
0.014600787311792374,
-0.003316545858979225,
0.007967694662511349,
-0.015125502832233906,
-0.03702668473124504,
-0.005771873518824577,
0.002104566665366292,
0.0020817527547478676,
-0.008218646049499512,
-0.026897387579083443,
-0.009479104541242123,
0.013129301369190216,
0.036821357905864716,
0.011423975229263306,
0.031597014516592026,
-0.04163505509495735,
0.04968830198049545,
0.037437330931425095,
0.004394494462758303,
0.00848670769482851,
-0.014098884537816048,
0.03116355463862419,
0.06661608815193176,
0.0045741526409983635,
-0.061825208365917206,
-0.00663309171795845,
0.008361231535673141,
-0.00970153883099556,
-0.03894303739070892,
0.038053300231695175,
-0.028471535071730614,
-0.004990503191947937,
0.060000110417604446,
-0.021946808323264122,
0.005626435857266188,
-0.022277606651186943,
-0.013665423728525639,
-0.08130813390016556,
-0.016505733132362366,
-0.03394683077931404,
-0.016882160678505898,
0.01787455752491951,
0.014384056441485882,
-0.039308056235313416,
0.013129301369190216,
0.024228181689977646,
0.022300420328974724,
0.03876052796840668,
0.029041877016425133,
-0.007825109176337719,
-0.00816161185503006,
-0.020486729219555855,
0.005874535534530878,
-0.06752864271402359,
-0.03919398784637451,
0.03428903594613075,
-0.01567303203046322,
0.03262363374233246,
0.0020389771088957787,
-0.010773783549666405,
-0.03182515129446983,
0.005783280357718468,
0.02808370068669319,
-0.026623621582984924,
-0.016813717782497406,
0.04067688062787056,
-0.009211042895913124,
-0.014030443504452705,
0.004343163687735796,
-0.00470533175393939,
-0.010363136418163776,
-0.03015975095331669,
0.07601534575223923,
0.030273819342255592,
-0.004497156478464603,
0.022060876712203026,
-0.004531376995146275,
0.03513314202427864,
0.02280232310295105,
-0.03759702667593956,
-0.017384061589837074,
-0.030410701408982277,
0.027513358741998672,
0.011076065711677074,
-0.011304203420877457,
0.01821676269173622,
0.0047737727873027325,
0.04434989020228386,
0.03780234977602959,
-0.01789737120270729,
-0.009433477185666561,
-0.007134994026273489,
-0.01369964424520731,
0.005965790245682001,
-0.015821320936083794,
-0.025711072608828545,
0.011389754712581635,
0.008737658150494099,
-0.0027262407820671797,
-0.04444114491343498,
-0.054068539291620255,
0.024433504790067673,
0.02990879863500595,
0.04152098670601845,
-0.016893567517399788,
0.05023583397269249,
0.014201547019183636,
-0.009250967763364315,
0.0016212007030844688,
-0.008572258986532688,
0.006416361313313246,
0.0038840374909341335,
-0.0721370130777359,
-0.0013510005082935095,
0.010619791224598885,
-0.010665418580174446,
0.009091271087527275,
0.02614453434944153,
-0.012467702850699425,
0.024866964668035507,
-0.035612232983112335,
0.050737734884023666,
-0.04179475083947182,
-0.025117916986346245,
0.01663120836019516,
0.0001257428666576743,
-0.01046579796820879,
-0.01753235049545765,
-0.05402291193604469,
-0.04599247872829437,
0.004223391879349947,
0.007477199658751488,
0.019186345860362053,
0.010420170612633228,
-0.008252866566181183,
0.035292837768793106,
0.05137651786208153,
0.06150581315159798,
-0.047270048409700394,
-0.0469050295650959,
0.02277950942516327,
0.008207239210605621,
0.05657804757356644,
-0.043939244002103806,
0.018695851787924767,
0.0005878100055269897,
0.01031180564314127,
-0.00296008144505322,
-0.02000764012336731,
0.0020760493353009224,
0.03638789802789688,
-0.01851334236562252,
0.009764276444911957,
0.0000012671199556280044,
-0.026623621582984924,
0.004103619605302811,
0.040790949016809464,
-0.009838420897722244,
-0.006895449943840504,
-0.0006637369515374303,
0.042068518698215485,
0.006724346894770861,
-0.007619785610586405,
-0.03116355463862419,
0.01750953681766987,
-0.06492787599563599,
0.01815972849726677,
-0.024136925116181374,
-0.03862364590167999,
0.0450114868581295,
-0.014749076217412949,
-0.031186368316411972,
-0.018695851787924767,
0.0039125545881688595,
0.04437270388007164,
0.024570386856794357,
-0.05324724316596985,
0.0315057598054409,
0.036159761250019073,
0.0013210575561970472,
0.03978714346885681,
0.03134606406092644,
-0.026053279638290405,
0.014692042022943497,
-0.034380290657281876,
-0.027558986097574234,
-0.015125502832233906,
-0.022574184462428093,
0.0010822262847796082,
0.005264268256723881,
-0.024798523634672165,
0.002864548936486244,
0.02561981789767742,
0.050098951905965805,
-0.03246393799781799,
0.030684465542435646,
-0.051330890506505966,
0.0486845001578331,
0.007494310382753611,
-0.008543741889297962,
0.016756683588027954,
-0.02313312143087387,
-0.010574163869023323,
0.027650240808725357,
-0.00013055512681603432,
-0.0200190469622612,
0.006290886085480452,
-0.06132330372929573,
0.03645633906126022,
0.018011439591646194,
-0.057490598410367966,
-0.035224396735429764,
0.03501907363533974,
0.013768086209893227,
0.05297347903251648,
-0.0002584367757663131,
0.057444971054792404,
-0.01277568843215704,
0.012057055719196796,
-0.02217494510114193,
0.01276428159326315,
0.0022100801579654217,
-0.011178727261722088,
0.013140708208084106,
-0.0068897465243935585,
0.0013467229437083006,
-0.020235778763890266,
-0.0400380939245224,
0.057171206921339035,
0.04950579255819321,
0.051604654639959335,
-0.056258656084537506,
0.028197769075632095,
-0.03604569286108017,
-0.050965871661901474,
-0.0022614109329879284,
0.02895062230527401,
0.01567303203046322,
-0.02029281295835972,
-0.055346108973026276,
0.04900389164686203,
-0.015045654959976673,
-0.0031397396232932806,
-0.012844129465520382,
0.002848864533007145,
0.021079886704683304,
0.020509542897343636,
0.029977241531014442,
-0.022277606651186943,
0.008247163146734238,
0.02243730239570141,
0.008971499279141426,
-0.041133154183626175,
-0.07122446596622467,
0.03846394643187523,
0.022106504067778587,
-0.024228181689977646,
-0.041178781539201736,
0.018695851787924767,
-0.01906087063252926,
0.05333849787712097,
-0.04845636337995529,
0.07683663815259933,
0.06552103161811829,
0.022425895556807518,
0.028813740238547325,
-0.01664261519908905,
-0.0009852679213508964,
-0.02835746668279171,
0.009045643731951714,
-0.02315593510866165,
0.020144524052739143,
0.0029828951228410006,
0.03422059491276741,
-0.06447160243988037,
0.017201552167534828,
-0.020269999280571938,
0.019015243276953697,
0.025209171697497368,
0.002518065506592393,
-0.05799249932169914,
-0.02246011607348919,
0.016129307448863983,
0.01431561540812254,
0.03111792728304863,
0.009250967763364315,
-0.0510571263730526,
0.0021416388917714357,
-0.010699639096856117,
-0.02276810258626938,
-0.018718665465712547,
0.04197726398706436,
-0.02621297538280487,
-0.034950632601976395,
-0.07492028921842575,
-0.04231946915388107,
0.05940695106983185,
-0.0035133142955601215,
0.04099627211689949,
0.0027647388633340597,
0.035315655171871185,
0.008201535791158676,
-0.007112180348485708,
-0.012593179009854794,
-0.0037585620302706957,
-0.035338468849658966,
-0.004186319187283516,
0.01003233715891838,
-0.013505727984011173,
0.03554379194974899,
0.031026672571897507,
0.03611413389444351,
0.042958252131938934,
0.007214841898530722,
-0.0038754823617637157,
0.01566162519156933,
-0.033376485109329224,
0.013574169017374516,
-0.0037271929904818535,
-0.031847964972257614,
0.004899248480796814,
0.006655905395746231,
-0.06949061900377274,
-0.007790888659656048,
0.003116925712674856,
0.02990879863500595,
-0.012456296011805534,
0.0012697266647592187,
-0.020452508702874184,
-0.019494332373142242,
0.02340688742697239,
0.02899624966084957,
-0.014726262539625168,
-0.01757797785103321,
-0.054068539291620255,
0.04432707652449608,
-0.04320920258760452,
-0.04060843959450722,
-0.053521011024713516,
0.03264644742012024,
0.009308001957833767,
0.001966258278116584,
-0.01138405129313469,
-0.009079864248633385,
0.024798523634672165,
0.01280990894883871,
-0.00671294005587697,
-0.014007629826664925,
-0.029475338757038116,
0.02530042640864849,
0.03264644742012024,
-0.02306468039751053,
0.021809926256537437,
-0.023201562464237213,
0.0026278565637767315,
0.0038754823617637157,
-0.010174923576414585,
0.018650224432349205,
-0.009536138735711575,
-0.0017081779660657048,
-0.014657821506261826,
-0.023041866719722748,
-0.0033878388348966837,
0.010739563032984734,
0.01818254217505455,
-0.009182525798678398,
0.004291832912713289,
0.006878339685499668,
0.030000055208802223,
0.03552097827196121,
0.02338407188653946,
0.006211037747561932,
0.0572168342769146,
0.044532399624586105,
0.022950612008571625,
-0.0363650843501091,
-0.042114146053791046,
0.023178748786449432,
-0.0044030495919287205,
-0.022300420328974724,
0.005495257209986448,
-0.023840347304940224,
-0.029635034501552582,
-0.008880244567990303,
0.005267119966447353,
0.02436506375670433,
-0.004109323024749756,
0.0075513445772230625,
-0.003978143911808729,
0.008646403439342976,
-0.012365041300654411,
-0.024798523634672165,
-0.010534239932894707,
-0.01722436584532261,
-0.026874573901295662,
-0.00019587726274039596,
-0.00041278591379523277,
-0.0011307054664939642,
0.03015975095331669,
-0.016243375837802887,
0.010328915901482105,
0.0031083705835044384,
0.001991923665627837,
-0.055619873106479645,
-0.04622061550617218,
0.004830807447433472,
-0.016152121126651764,
0.01479470357298851,
-0.025802327319979668,
0.007283282931894064,
-0.008446783758699894,
-0.0034933523274958134,
0.0014158771373331547,
-0.0019691099878400564,
-0.012627399526536465,
0.0003345419536344707,
-0.04186319187283516,
0.0024082742165774107,
-0.012216752395033836,
0.0032110323663800955,
-0.0078479228541255,
-0.017817523330450058,
-0.04302669316530228,
-0.011794698424637318,
-0.029201574623584747,
-0.025209171697497368,
-0.054342303425073624,
-0.009045643731951714,
-0.026737691834568977,
-0.027353661134839058,
0.0015370750334113836,
-0.003963885363191366,
-0.016471512615680695,
-0.0072889868170022964,
0.027832750231027603,
-0.015193943865597248,
0.004197726026177406,
-0.034106526523828506,
-0.034676868468523026,
0.02863123081624508,
-0.0013723884476348758,
0.0004584133857861161,
-0.015205350704491138,
-0.014726262539625168,
-0.012456296011805534,
-0.01077948696911335,
0.002093159593641758,
-0.017646418884396553,
0.05183279514312744,
0.0013795177219435573,
0.016140714287757874,
-0.02347532846033573,
0.000851950200740248,
0.008024729788303375,
-0.0009439180721528828,
0.02958940714597702,
-0.00023205840261653066,
0.03855520114302635,
-0.009239560924470425,
-0.006724346894770861,
0.042114146053791046,
0.016790904104709625,
-0.02650955319404602,
0.008600776083767414,
0.03367306664586067,
0.00616541039198637,
0.015832727774977684,
0.000560005777515471,
-0.014920178800821304,
-0.03451717272400856,
0.049460165202617645,
-0.0035617935936897993,
-0.04432707652449608,
-0.016254782676696777,
0.014623600989580154,
0.03688979893922806,
0.03848676010966301,
-0.03054758347570896,
0.02370346523821354,
0.0049733929336071014,
0.005133089143782854,
-0.021490532904863358,
0.005851721856743097,
-0.008880244567990303,
-0.014212953858077526,
0.018239576369524002,
0.0036444934085011482,
-0.008657810278236866,
-0.017178738489747047,
0.015102689154446125,
-0.043916430324316025,
-0.015114095993340015,
-0.001869299914687872,
0.012387854978442192,
-0.016231968998908997,
0.00878328550606966,
-0.009627393446862698,
-0.015775693580508232,
0.03520158305764198,
0.0067471605725586414,
-0.016779497265815735,
0.03627382963895798,
-0.01294679194688797,
-0.03136887773871422,
0.011783291585743427,
0.012501923367381096,
0.0082927905023098,
-0.0206692386418581,
-0.010870741680264473,
0.02801525965332985,
-0.014920178800821304,
-0.015821320936083794,
-0.00763689586892724,
0.007442979142069817,
-0.03971870243549347,
0.02151334658265114,
-0.009752869606018066,
0.00799050834029913,
-0.0010651160264387727,
0.011737664230167866,
0.005711987614631653,
0.011931580491364002,
-0.0319848470389843,
0.016859347000718117,
0.07031191140413284,
-0.031597014516592026,
-0.005372633226215839,
-0.002288502175360918,
0.032783329486846924,
0.004075102508068085,
0.0006562512135133147,
0.021022852510213852,
-0.018330831080675125,
-0.015536149963736534,
-0.0006198917981237173,
0.03481375053524971,
0.009747166186571121,
0.02527761273086071,
0.013140708208084106,
0.025665445253252983,
0.009667318314313889,
0.01787455752491951,
-0.0008512372733093798,
-0.011817512102425098,
0.040174975991249084,
-0.023794719949364662,
0.007357427850365639,
-0.022927798330783844,
-0.06319402903318405,
-0.01372245792299509,
-0.016277596354484558,
0.015342232771217823,
0.009370739571750164,
0.014566565863788128,
0.005897349212318659,
0.015764286741614342,
0.001500002690590918,
-0.011058955453336239,
-0.03693542629480362,
-0.03657040745019913,
0.009946785867214203,
-0.019665434956550598,
-0.016117900609970093,
-0.01434983592480421,
-0.039262428879737854,
0.026988642290234566,
0.018673038110136986,
0.029977241531014442,
-0.054114166647195816,
0.04047155752778053,
0.001432274468243122,
-0.006131189875304699,
-0.015353639610111713,
0.023863160982728004,
0.014520938508212566,
-0.01792018488049507,
0.006553243845701218,
-0.021171141415834427,
-0.042410723865032196,
-0.021125514060258865,
-0.016266189515590668,
0.0034591318108141422,
0.031574200838804245,
0.018730072304606438,
-0.0022286162711679935,
0.005543736275285482,
0.01730421371757984,
-0.008743361569941044,
0.00892016850411892,
0.0325780063867569,
0.017064670100808144,
-0.006022824440151453,
0.040539998561143875,
-0.01599242351949215,
0.0053441161289811134,
-0.021353650838136673,
-0.022277606651186943,
-0.003171108430251479,
-0.020463915541768074,
-0.006307996343821287,
0.005626435857266188,
-0.01295819878578186,
-0.04138410463929176,
-0.0013852211413905025,
0.009114084765315056,
0.015193943865597248,
-0.032212987542152405,
-0.03942212462425232,
0.013904968276619911,
-0.0007535659824497998,
0.026600807905197144,
0.0037671171594411135,
0.01815972849726677,
0.0012240991927683353,
-0.02313312143087387,
0.003262363374233246,
0.006912560202181339,
-0.041726309806108475,
-0.0011036142241209745,
0.014942992478609085,
-0.0572168342769146,
0.01340306643396616,
0.0028274767100811005,
-0.010163516737520695,
-0.0255285631865263,
-0.0036501968279480934,
0.025688258931040764,
-0.027262406423687935,
0.004539932124316692,
0.01665402203798294,
0.004009513184428215,
0.025095103308558464,
0.024456318467855453,
-0.012912570498883724,
0.018935395404696465,
-0.008663513697683811,
-0.028266210108995438,
0.007374538108706474,
-0.004057992249727249,
0.006285182666033506,
-0.006228148005902767,
-0.032190173864364624,
-0.04713316634297371,
0.00554088456556201,
-0.03052476979792118,
0.013551355339586735,
-0.014954399317502975,
-0.009273781441152096,
0.017714861780405045,
-0.009176822379231453,
0.012228159233927727,
0.013072267174720764,
0.01603805273771286,
-0.02347532846033573,
-0.016847940161824226,
0.004551338963210583,
0.01904946379363537,
-0.00803043320775032,
0.02587077021598816,
-0.016414478421211243,
-0.015935389325022697,
0.01231941394507885,
-0.06771115213632584,
-0.01909509114921093,
0.00716921454295516,
0.014418276958167553,
-0.013654016889631748,
-0.021798519417643547,
-0.031231995671987534,
0.025733886286616325,
0.013517134822905064,
-0.046060919761657715,
-0.00895438902080059,
-0.013095080852508545,
0.0015399267431348562,
-0.0038355581928044558,
-0.014692042022943497,
-0.019334636628627777,
-0.011304203420877457,
-0.012524737976491451,
0.0012918274151161313,
0.022277606651186943,
0.002706278581172228,
0.012912570498883724,
-0.010551350191235542,
0.046357497572898865,
-0.006735753733664751,
0.003918258007615805,
-0.01721295900642872,
-0.04006090760231018,
-0.030935417860746384,
-0.047908831387758255,
-0.028539976105093956,
0.017680641263723373,
-0.018684444949030876,
0.01947151869535446,
-0.02707989700138569,
0.0018507638014853,
0.00770533736795187,
-0.009695835411548615,
-0.009496214799582958,
-0.01636885106563568,
0.006792787928134203,
0.021330837160348892,
0.031209181994199753,
0.013802306726574898,
-0.027901191264390945,
-0.02523198537528515,
-0.027627427130937576,
-0.009262374602258205,
0.023931602016091347,
-0.02523198537528515,
0.014110291376709938,
-0.0070095183327794075,
-0.01760079152882099,
-0.0003931803803425282,
0.012433482334017754,
-0.007693930063396692,
-0.028220582753419876,
0.02954377979040146,
-0.009650208055973053,
0.009461994282901287,
0.0013802306493744254,
0.02160460129380226,
0.03428903594613075,
0.004060843959450722,
-0.00167538330424577,
-0.004431567154824734,
-0.042068518698215485,
0.022254792973399162,
-0.027809936553239822,
0.019197752699255943,
0.0066387951374053955,
0.007226248737424612,
-0.05612177401781082,
0.01792018488049507,
-0.03597725182771683,
0.00830419734120369,
-0.006587464362382889,
-0.02093159593641758,
-0.0067186434753239155,
0.008195832371711731,
-0.01729280687868595,
-0.013129301369190216,
-0.01522816438227892,
0.02801525965332985,
-0.015844134613871574,
0.009233856573700905,
0.018068473786115646,
0.031254809349775314,
-0.006182520650327206,
-0.0013952021254226565,
0.004682518076151609,
-0.025368867442011833,
0.036524780094623566,
-0.004867879673838615,
0.03850957378745079,
-0.01904946379363537,
-0.015456302091479301,
-0.02744491584599018,
0.0031482947524636984,
-0.001090781413950026,
0.025962024927139282,
-0.07282142341136932,
0.012684433721005917,
-0.028471535071730614,
-0.00845248717814684,
0.001295392052270472,
-0.012855536304414272,
-0.012707247398793697,
0.012695840559899807,
0.02342970110476017,
0.013346032239496708,
-0.011230058036744595,
0.015787100419402122,
-0.031186368316411972,
0.011652112007141113,
-0.013585575856268406,
-0.0052728233858942986,
-0.008372638374567032,
0.0148061104118824,
0.011749071069061756,
0.04348296672105789,
0.020155930891633034,
-0.01875288598239422,
-0.009456290863454342,
-0.012695840559899807,
0.0058574252761900425,
0.011794698424637318,
0.006262368988245726,
0.00671294005587697,
-0.002366924425587058,
0.015342232771217823,
-0.007688226643949747,
0.019813723862171173,
-0.002673483919352293,
0.004582707770168781,
0.022254792973399162,
0.014965806156396866,
0.019231973215937614,
0.026372671127319336,
0.013117894530296326,
-0.01539926789700985,
0.004251908976584673,
-0.020406881347298622,
-0.007842219434678555,
0.03045632876455784,
-0.015456302091479301,
-0.045125555247068405,
-0.0029743399936705828,
0.0319848470389843,
-0.012011428363621235,
-0.0058574252761900425,
-0.012250972911715508,
0.05019020661711693,
0.04195445030927658,
0.002721963217481971,
0.026577994227409363,
0.021330837160348892,
-0.0013431583065539598,
-0.02559700421988964,
-0.00430323975160718,
-0.026714878156781197,
0.03739170357584953,
-0.05790124461054802,
-0.012216752395033836,
0.006576057523488998,
-0.025460122153162956,
0.01972246915102005,
-0.0014094606740400195,
0.015638811513781548,
-0.03177952393889427,
0.006507616490125656,
-0.07505717128515244,
0.029338456690311432,
-0.03907991945743561,
-0.027924004942178726,
0.044213008135557175,
-0.0012576068984344602,
0.01910649798810482,
0.023908788338303566,
0.0237490925937891,
-0.039011478424072266,
0.024091297760605812,
0.017087483778595924,
0.041406918317079544,
0.050098951905965805,
-0.004519970156252384,
-0.006330810021609068,
-0.008692030794918537,
0.018387865275144577,
-0.04031186178326607,
-0.00161692313849926,
-0.04225102812051773,
0.030889790505170822,
0.061414558440446854,
0.01971106231212616,
-0.031186368316411972,
-0.01598101668059826,
-0.009975302964448929,
-0.043711107224226,
-0.033148348331451416,
-0.02591639757156372,
0.023931602016091347,
0.045467764139175415,
-0.013300403952598572,
-0.026555180549621582,
0.01601523905992508,
0.01785174384713173,
-0.038327064365148544,
-0.02340688742697239,
0.015136909671127796,
-0.00493917241692543,
0.03266926109790802,
-0.03166545554995537,
0.043893616646528244,
0.011423975229263306,
0.01093918364495039,
0.0037956342566758394,
0.017030449584126472,
-0.05082898959517479,
-0.010967700742185116,
-0.0137110510841012,
-0.029384084045886993,
-0.017817523330450058,
-0.022882170975208282,
-0.012730061076581478,
0.026920201256871223,
0.0165855810046196,
0.046676889061927795,
0.01277568843215704,
0.007631192449480295,
0.00847530085593462,
0.022688254714012146,
0.03330804407596588,
0.008697734214365482,
-0.002161600859835744,
0.013368845917284489,
0.0024367915466427803,
-0.006404954474419355,
0.03485937789082527,
0.015764286741614342,
0.03727763518691063,
0.017498129978775978,
-0.005013316869735718,
-0.05516359955072403,
-0.027558986097574234,
-0.0066102780401706696,
0.026692064478993416,
-0.008481004275381565,
-0.02680613286793232,
-0.013551355339586735,
-0.021205361932516098,
0.016505733132362366,
0.043962057679891586,
0.025688258931040764,
0.032828956842422485,
-0.02312171459197998,
0.020589390769600868,
-0.00010016652959166095,
0.005121682304888964,
-0.002217209432274103,
-0.01724717952311039,
-0.028585603460669518,
-0.026669248938560486,
0.0009489085641689599,
0.02280232310295105,
-0.018102694302797318,
-0.0014394037425518036,
-0.021114107221364975,
0.023281410336494446,
-0.023589396849274635,
-0.013790899887681007,
-0.003938219975680113,
-0.034060899168252945,
-0.023885974660515785,
-0.01786315068602562,
-0.03923961520195007,
0.013642610050737858,
-0.021205361932516098,
0.00401521660387516,
-0.04072250798344612,
0.0044401222839951515,
0.011503823101520538,
-0.008252866566181183,
-0.007425868883728981,
0.016140714287757874,
0.024205366149544716,
-0.027855563908815384,
-0.025688258931040764,
-0.00987834483385086,
0.01721295900642872,
-0.034631241112947464,
0.009941082447767258,
-0.007950584404170513,
-0.0265323668718338,
-0.0012775688664987683,
-0.04827385023236275,
-0.014406870119273663,
0.004947727546095848,
0.003929664846509695,
-0.006102672778069973,
-0.01632322371006012,
0.03168826922774315,
0.010762376710772514,
0.00223004212602973,
-0.008577962405979633,
-0.012125497683882713,
-0.009404960088431835,
-0.03798485919833183,
0.036524780094623566,
-0.004123581573367119,
-0.04772632196545601,
0.037551399320364,
0.02685176022350788,
-0.010671121999621391,
0.005064648110419512,
-0.010785190388560295,
-0.00906275399029255,
-0.012000021524727345,
0.0425247922539711,
0.008423970080912113,
-0.01844489946961403,
0.03171108290553093,
-0.0037728205788880587,
-0.029498152434825897,
-0.03453998640179634,
-0.01372245792299509,
-0.0037471551913768053,
-0.006570354104042053,
-0.025391681119799614,
-0.0009175396990031004,
0.0009653059532865882,
-0.012832722626626492,
-0.025688258931040764,
0.006958187557756901,
0.008977202698588371,
0.01526238489896059,
-0.007100773509591818,
-0.03385557606816292,
0.027330847457051277,
-0.008252866566181183,
-0.02311030775308609,
0.013825120404362679,
-0.008064653724431992,
0.00517301307991147,
0.01570725254714489,
0.020509542897343636,
-0.017657827585935593,
-0.01906087063252926,
-0.03143731877207756,
-0.011133099906146526,
0.06365030258893967,
-0.0051159788854420185,
-0.029110318049788475,
0.022403081879019737,
0.04895826429128647,
-0.0028859367594122887,
0.004280426073819399,
0.028243396431207657,
0.0008063227287493646,
-0.026943014934659004,
-0.006034231279045343,
0.03143731877207756,
0.04031186178326607,
-0.005121682304888964,
0.003365025157108903,
0.01880992017686367,
-0.014384056441485882,
-0.0002261767367599532,
-0.008121687918901443,
-0.004936320707201958,
-0.014703448861837387,
0.0021601750049740076,
-0.0356578603386879,
-0.0023170195054262877,
0.0017509537283331156,
0.026349857449531555,
0.051330890506505966,
0.0007877866155467927,
0.0010679677361622453,
0.035908810794353485,
0.013083674013614655,
-0.006233851425349712,
-0.02157038077712059,
-0.01975668966770172,
-0.013539948500692844,
0.0005596493138000369,
-0.03946775197982788,
-0.016414478421211243,
0.0031083705835044384,
0.01697341538965702,
0.04428144916892052,
0.015011434443295002,
0.025962024927139282,
-0.027581799775362015,
-0.030593210831284523,
0.01542208157479763,
-0.014110291376709938,
0.015034248121082783,
-0.03171108290553093,
0.01947151869535446,
-0.025368867442011833,
-0.021022852510213852,
0.024570386856794357,
-0.001884984434582293,
-0.006593167781829834,
0.025414494797587395,
-0.010214847512543201,
0.0524715781211853,
0.02491259202361107,
0.026874573901295662,
-0.009125491604208946,
0.007494310382753611,
-0.054661694914102554,
0.008389748632907867,
0.009319408796727657,
0.03574911504983902,
0.029452525079250336,
-0.01846771314740181,
-0.039878398180007935,
-0.008669217117130756,
-0.0006156142335385084,
-0.005135940853506327,
-0.0013353161048144102,
0.007117883767932653,
-0.021684449166059494,
0.01539926789700985,
0.016231968998908997,
0.028311837464571,
0.0042975363321602345,
-0.01601523905992508,
0.011401161551475525,
-0.02093159593641758,
0.004172060638666153,
-0.007283282931894064,
-0.01846771314740181,
-0.0005485988804139197,
0.0077224476262927055,
-0.009684428572654724,
-0.008766175247728825,
0.011543747037649155,
0.007020925171673298,
0.033399298787117004,
0.06018261983990669,
0.030410701408982277,
-0.003658751957118511,
-0.02897343598306179,
-0.010368839837610722,
-0.02251715026795864,
0.030661651864647865,
0.022357454523444176,
0.017201552167534828,
0.006815601605921984,
-0.016163527965545654,
-0.034106526523828506,
-0.034060899168252945,
-0.013003826141357422,
-0.02340688742697239,
-0.0007435849984176457,
0.016266189515590668,
-0.024821337312459946,
-0.006804194767028093,
-0.01014640647917986,
-0.020760493353009224,
-0.018901174888014793,
-0.01845630630850792,
0.005868832115083933,
-0.021855553612113,
-0.014885958284139633,
-0.008754768408834934,
0.015581777319312096,
0.002600765088573098,
0.0005714126164093614,
-0.007448682561516762,
-0.006604574620723724,
0.0020532356575131416,
-0.009114084765315056,
0.024410691112279892,
0.037117939442396164,
-0.010414467193186283,
-0.007654006127268076,
-0.009484807960689068,
0.005093165207654238,
-0.006273775827139616,
-0.024889778345823288,
0.023030459880828857,
0.0006373585783876479,
0.000006232559371710522,
0.022300420328974724,
0.049186401069164276,
-0.015627404674887657,
-0.019585587084293365,
0.004702480044215918,
-0.0020560873672366142,
0.010984811000525951,
0.0036501968279480934,
0.01140686497092247,
-0.019870758056640625,
-0.030045682564377785,
0.0054724435321986675,
0.007152104284614325,
-0.009484807960689068,
-0.0012198216281831264,
0.0053925951942801476,
-0.008201535791158676,
0.010231957770884037,
-0.012923977337777615,
-0.03919398784637451,
-0.07971116900444031,
0.004354570526629686,
0.008925871923565865,
-0.03173389658331871,
-0.010083668865263462,
-0.01111598964780569,
0.01967684179544449,
0.04444114491343498,
-0.0006883330061100423,
-0.013460100628435612,
0.056213028728961945,
0.024250995367765427,
-0.02129661664366722,
-0.007425868883728981,
0.014988620765507221,
0.039285242557525635,
-0.018718665465712547,
0.0016383109614253044,
-0.015022841282188892,
0.007260469254106283,
0.021456312388181686,
-0.03230424225330353,
0.031254809349775314,
0.01079089380800724,
-0.007140697445720434,
0.05050959810614586,
0.016756683588027954,
-0.02532324008643627,
0.03460842743515968,
-0.0006277339998632669,
-0.008058950304985046,
-0.014452497474849224,
-0.014212953858077526,
-0.019505739212036133,
-0.005375484935939312,
0.012102683074772358,
-0.02151334658265114,
0.018604597076773643,
-0.007420165464282036,
0.01876429282128811,
-0.01753235049545765,
-0.006342216860502958,
-0.0023740536998957396,
0.02003045380115509,
-0.0010793745750561357,
0.0010116463527083397,
-0.03077572025358677,
0.0034192076418548822,
-0.00006376259261742234,
-0.014840330928564072,
0.009872641414403915,
-0.04127003625035286,
0.006193927489221096,
-0.013539948500692844,
-0.01667683571577072,
0.024182552471756935,
0.004799438174813986,
-0.004568449221551418,
0.010579867288470268,
-0.007249062415212393,
-0.008138798177242279,
-0.04092783108353615,
0.0141559187322855,
-0.017692048102617264,
0.0026620770804584026,
0.004089361056685448,
0.007568454835563898,
0.03675291687250137,
-0.002250004094094038,
-0.010174923576414585,
-0.006929670460522175,
-0.005546587985008955,
-0.029657848179340363,
0.006496209651231766,
-0.012000021524727345,
-0.03476812317967415,
-0.0012732913019135594,
-0.012273786589503288,
-0.0008647829527035356,
-0.032828956842422485,
-0.0003247391723562032,
-0.009519028477370739,
0.010996217839419842,
-0.05415979400277138,
-0.028448721393942833,
-0.024798523634672165,
0.009889751672744751,
0.0013460100162774324,
0.024570386856794357,
-0.012171125039458275,
-0.010745266452431679,
-0.027490543201565742,
0.01815972849726677,
-0.004343163687735796,
0.02037266083061695,
-0.0055009606294333935,
-0.025003846734762192,
0.01909509114921093,
-0.013346032239496708,
-0.040790949016809464,
-0.03084416314959526,
-0.019494332373142242,
0.01575287990272045,
-0.002957229735329747,
-0.02530042640864849,
-0.008851727470755577,
0.014064664021134377,
-0.004682518076151609,
0.010836521163582802,
-0.027536172419786453,
-0.01813691481947899,
-0.013825120404362679,
0.002585080685093999,
0.005412557162344456,
0.022026656195521355,
-0.03939931094646454,
-0.011657815426588058,
-0.00492776557803154,
0.02555137686431408,
-0.0296122208237648,
-0.009792793542146683,
0.025117916986346245,
-0.015946796163916588,
-0.025163544341921806,
0.029429711401462555,
0.00392396142706275,
-0.03426622226834297,
-0.000520794652402401,
-0.012593179009854794,
-0.0432320162653923,
0.00004052555959788151,
-0.03513314202427864,
0.010933480225503445,
0.02646392583847046,
0.02646392583847046,
0.004060843959450722,
0.0027818491216748953,
-0.024593200534582138,
0.021501939743757248,
0.015296605415642262,
-0.005683470517396927,
0.017783302813768387,
-0.023931602016091347,
-0.029794730246067047,
0.006530430167913437,
0.031574200838804245,
-0.0036501968279480934,
0.016437292098999023,
0.014098884537816048,
0.007414462044835091,
-0.021467719227075577,
-0.009906861931085587,
-0.001966258278116584,
0.014509531669318676,
-0.02461601421236992,
0.010967700742185116,
0.019528552889823914,
0.014030443504452705,
0.009935379028320312,
0.02495821937918663,
0.016836533322930336,
0.005001910030841827,
0.0068384152837097645,
0.0011706295190379024,
-0.006233851425349712,
-0.04800008609890938,
-0.031528573483228683,
0.1287606954574585,
-0.0006744308630004525,
0.004385939333587885,
0.016802310943603516,
-0.024273809045553207,
0.000511526595801115,
0.02277950942516327,
-0.007950584404170513,
0.0006566076772287488,
0.010517129674553871,
0.02129661664366722,
-0.016505733132362366,
0.04955141991376877,
0.038030486553907394,
0.015832727774977684,
-0.013608389534056187,
-0.004517118446528912,
0.0246388278901577,
0.02924720197916031,
-0.014406870119273663,
0.0307985357940197,
-0.0005250722169876099,
-0.009005719795823097,
0.03298865258693695,
-0.0268289465457201,
-0.02436506375670433,
-0.018000032752752304,
0.010214847512543201,
-0.0025537118781358004,
0.013517134822905064,
0.01630041003227234,
0.009028533473610878,
0.025368867442011833,
-0.03479093685746193,
0.01843349263072014,
-0.01947151869535446,
0.015285198576748371,
-0.01340306643396616,
-0.018866954371333122,
0.025779513642191887,
0.003929664846509695,
0.014201547019183636,
-0.006827008444815874,
-0.0025351757649332285,
0.02034984715282917,
0.05475294962525368,
-0.019220566377043724,
-0.00025683268904685974,
0.002143064746633172,
-0.008093170821666718,
-0.002533749910071492,
0.011019031517207623,
0.014121698215603828,
-0.013015232980251312,
-0.047041911631822586,
-0.013904968276619911,
0.020555170252919197,
-0.002006182447075844,
-0.005965790245682001,
-0.020098894834518433,
-0.014269988052546978,
0.018068473786115646,
-0.00848670769482851,
-0.035612232983112335,
-0.007961991243064404
] | 2025-01-08 | 1 | 39776055 | [
"immune effector cell toxicities",
"immune checkpoint inhibitors",
"toxicities",
"chimeric antigen receptor T-cell therapy",
"antigen receptor T-cell therapy",
"targeted drug therapies",
"treatment regimens",
"specialist treatment",
"antigen receptor T-cells",
"clinical trials",
"anticipated complications",
"systematic reviews",
"infective complications",
"solid organ tumours",
"critical care",
"Patients",
"pharmacological management",
"cohort studies",
"significant improvements",
"pathophysiology",
"complications",
"significant advances",
"electronic databases",
"diagnostic biomarkers",
"T-cell and immune checkpoint",
"predictive models",
"targeted immunotherapy",
"cytokine release syndrome",
"Management",
"management"
] | [
"critical care",
"cytokine release syndrome",
"immune checkpoint inhibitors",
"receptors, chimeric antigen"
] | 0 | 10.1111/anae.16453 | [
"Carter",
"Wigmore"
] | [
"East of England School of Anaesthesia, Basildon, UK.",
"Department of Critical Care, The Royal Marsden Hospital, London, UK."
] | [
"39776055"
] | [] | 6.23885 | 3.934823 |
39775969 | 59 | Mutant Calreticulin in MPN: Mechanistic Insights and Therapeutic Implications. | More than a decade following the discovery of Calreticulin (CALR) mutations as drivers of myeloproliferative neoplasms (MPN), advances in the understanding of CALR-mutant MPN continue to emerge. Here, we summarize recent advances in mehanistic understanding and in targeted therapies for CALR-mutant MPN.
Structural insights revealed that the mutant CALR-MPL complex is a tetramer and the mutant CALR C-terminus is exposed on the cell surface. Targeting mutant CALR utilizing antibodies is the leading therapeutic approach, while mutant CALR-directed vaccines are also in early clinical trials. Additionally, chimeric antigen receptor (CAR) T-cells directed against mutant CALR are under evaluation in preclinical models. Approaches addressing the cellular effects of mutant CALR beyond MPL-JAK-STAT activation, such as targeting the unfolded protein response, proteasome, and N-glycosylation pathways, have been tested in preclinical models. In CALR-mutant MPN, the path from discovery to mechanistic understanding to direct therapeutic targeting has advanced rapidly. The longer-term goal remains clonally-selective therapies that modify the disease course in patients. | [
0.0161287859082222,
0.03511332347989082,
0.062031883746385574,
0.041718799620866776,
-0.05140352249145508,
0.006487521808594465,
0.019506022334098816,
-0.010827022604644299,
-0.01470091100782156,
0.003122702008113265,
0.046933650970458984,
-0.059300296008586884,
-0.03176091983914375,
0.04680948704481125,
0.024447714909911156,
-0.018264392390847206,
0.07017698138952255,
-0.003526231972500682,
0.00040935020660981536,
0.08189798146486282,
0.014911987818777561,
-0.009647472761571407,
0.002500334521755576,
0.010845647193491459,
-0.012006571516394615,
0.0034951912239193916,
-0.014688494615256786,
0.015383807942271233,
-0.00772294495254755,
-0.002089044079184532,
0.04060133174061775,
-0.012714301235973835,
-0.043829575181007385,
0.03275422379374504,
-0.007009007036685944,
0.008728666231036186,
0.005186913534998894,
-0.008554837666451931,
-0.06511113047599792,
0.003507607616484165,
0.039508696645498276,
-0.019121117889881134,
-0.022883258759975433,
0.07842141389846802,
-0.008523796685039997,
0.007816066965460777,
-0.004373645409941673,
0.0032158242538571358,
0.020151671022176743,
0.016178451478481293,
-0.03193474933505058,
0.0286816768348217,
-0.027440045028924942,
0.05378745496273041,
-0.048597436398267746,
0.06461447477340698,
0.025999752804636955,
-0.030966276302933693,
0.026198413223028183,
-0.04509603604674339,
0.0003028415667358786,
-0.011156054213643074,
-0.015644550323486328,
-0.011491294950246811,
-0.07305756956338882,
0.006468897685408592,
-0.06689907610416412,
-0.02490711770951748,
0.0286816768348217,
0.0038180153351277113,
-0.0185251347720623,
-0.05264515429735184,
0.006990382447838783,
0.003159950952976942,
0.0018345097778365016,
-0.019468773156404495,
-0.020511744543910027,
0.04964040592312813,
-0.012254897505044937,
0.0178670696914196,
0.02352890744805336,
-0.02843334898352623,
0.01717175729572773,
-0.009361897595226765,
0.01209348626434803,
0.02218794636428356,
0.004733718000352383,
-0.03203408047556877,
-0.030568955466151237,
-0.0058046248741447926,
-0.00839342549443245,
0.02667023427784443,
-0.04698331654071808,
0.05378745496273041,
0.003622458316385746,
0.00911977980285883,
0.0004912202712148428,
-0.036255624145269394,
0.0406261645257473,
0.015507970936596394,
0.011770661920309067,
0.021331220865249634,
0.012546680867671967,
-0.05905197188258171,
0.027315881103277206,
-0.04740547016263008,
0.00476786307990551,
-0.011193303391337395,
0.040055014193058014,
-0.04238928109407425,
0.03993085399270058,
-0.005276931915432215,
0.006518562790006399,
0.01599220745265484,
-0.026620568707585335,
-0.04733097180724144,
-0.061932552605867386,
0.010541447438299656,
0.04440072551369667,
0.04353158175945282,
-0.05502908676862717,
0.07886840403079987,
0.02162921242415905,
-0.04363091289997101,
0.007573949173092842,
-0.03414485231041908,
0.0804080218076706,
0.0018686546245589852,
-0.0006448720814660192,
-0.02000267617404461,
0.04343225061893463,
-0.0034486299846321344,
-0.009411563165485859,
-0.019953010603785515,
-0.029948139563202858,
-0.06317418813705444,
0.022014116868376732,
-0.009473644196987152,
-0.04238928109407425,
-0.0060188062489032745,
0.0012090381933376193,
0.02484503574669361,
-0.023206083104014397,
-0.006105720531195402,
-0.031015941873192787,
-0.02798636257648468,
0.003935970366001129,
0.025751426815986633,
-0.006872427649796009,
0.012999876402318478,
-0.013583443127572536,
0.021678877994418144,
0.008244429714977741,
0.023330247029662132,
-0.03777041658759117,
-0.07578915357589722,
-0.009666097350418568,
0.05686669796705246,
-0.003271697787567973,
-0.049392081797122955,
-0.013757271692156792,
0.02256043441593647,
-0.029451487585902214,
0.004662324208766222,
0.04680948704481125,
-0.049665238708257675,
-0.007667071186006069,
0.018574800342321396,
-0.025627262890338898,
0.01585562713444233,
-0.00962263997644186,
-0.04027850925922394,
-0.05880364403128624,
-0.019717101007699966,
-0.04370541125535965,
-0.009672305546700954,
-0.02114497497677803,
-0.02221277914941311,
-0.04849810525774956,
-0.027762869372963905,
-0.024174556136131287,
0.004985148552805185,
0.0069096763618290424,
0.011211927980184555,
0.005075166467577219,
0.016948262229561806,
-0.047976620495319366,
0.02215069718658924,
-0.04010467976331711,
-0.005270723719149828,
0.009976505301892757,
0.020946314558386803,
0.049218252301216125,
0.009473644196987152,
-0.029774311929941177,
0.008921118453145027,
0.061932552605867386,
0.06208154931664467,
-0.018251975998282433,
-0.05731368809938431,
0.00986475870013237,
-0.025180276483297348,
0.006922092754393816,
-0.018227143213152885,
-0.011572000570595264,
0.028731340542435646,
0.0014076991938054562,
0.010082043707370758,
-0.011373340152204037,
0.04400340095162392,
0.059200964868068695,
0.019754348322749138,
0.0029007603880017996,
0.039508696645498276,
0.030171632766723633,
-0.020151671022176743,
-0.026272911578416824,
0.03556030988693237,
0.009045281447470188,
-0.0024196284357458353,
0.02290809154510498,
-0.009374313987791538,
-0.020238585770130157,
0.044351059943437576,
-0.038465727120637894,
0.004019780550152063,
0.04961557313799858,
-0.03938453644514084,
0.03354886919260025,
-0.03486499935388565,
0.03565964102745056,
0.006816554348915815,
0.008126474916934967,
-0.0008311167475767434,
-0.032009247690439224,
-0.03603213280439377,
-0.027042722329497337,
0.029525985941290855,
0.04452488571405411,
-0.02135605365037918,
0.024547044187784195,
0.01141679659485817,
0.034815333783626556,
0.027738036587834358,
-0.021815456449985504,
0.0026167372707277536,
-0.005447655916213989,
-0.05438343808054924,
0.024646375328302383,
0.034120019525289536,
0.030246131122112274,
0.029898473992943764,
-0.013707606121897697,
0.013111623004078865,
0.007816066965460777,
0.048522938042879105,
-0.013471696525812149,
-0.002020754385739565,
-0.007927813567221165,
-0.007989895530045033,
0.013260618783533573,
0.03479050099849701,
-0.02459670975804329,
-0.026198413223028183,
-0.024894701316952705,
0.010504198260605335,
-0.00029178327531553805,
0.013546193949878216,
0.010578695684671402,
-0.005196225829422474,
0.013931099325418472,
0.011578208766877651,
-0.014676078222692013,
0.006425440311431885,
-0.0679420456290245,
0.020772486925125122,
0.013273035176098347,
-0.0051310402341187,
0.041445642709732056,
-0.00593499606475234,
-0.002484814031049609,
-0.003777662292122841,
0.06635276228189468,
0.009169444441795349,
0.0034269015304744244,
0.012695676647126675,
0.01727108657360077,
-0.0295756496489048,
-0.009194277226924896,
-0.03635495528578758,
0.001098843407817185,
-0.02339232712984085,
0.005764272063970566,
-0.05577406287193298,
-0.029699813574552536,
0.02532927319407463,
-0.01470091100782156,
-0.01034899428486824,
-0.027315881103277206,
0.03339987248182297,
-0.029650148004293442,
0.043829575181007385,
-0.01599220745265484,
-0.051155198365449905,
-0.022684598341584206,
0.041991960257291794,
0.008989408612251282,
-0.0617835596203804,
-0.010100668296217918,
0.05676737055182457,
0.022548018023371696,
-0.025478268042206764,
0.030519289895892143,
-0.014676078222692013,
0.015259644947946072,
0.011752037331461906,
0.02833401970565319,
-0.055575404316186905,
0.0317857526242733,
-0.028731340542435646,
0.009672305546700954,
-0.027961529791355133,
0.006990382447838783,
0.026372242718935013,
0.003600729862228036,
-0.021194640547037125,
0.008976992219686508,
-0.015520387329161167,
0.034740835428237915,
-0.013484112918376923,
0.013757271692156792,
-0.022895675152540207,
0.036255624145269394,
-0.00006557363667525351,
-0.02439804933965206,
0.0102620804682374,
-0.0008016279898583889,
-0.019977843388915062,
0.015433473512530327,
0.01955568790435791,
-0.02992330677807331,
0.038788553327322006,
-0.027241384610533714,
0.02595008723437786,
0.002823158400133252,
-0.04370541125535965,
-0.021964453160762787,
0.008492755703628063,
-0.03749725595116615,
0.029550816863775253,
0.0024273886810988188,
0.010634569451212883,
0.023230915889143944,
0.005137248430401087,
0.009063906036317348,
0.04996323212981224,
0.012323187664151192,
-0.023305414244532585,
0.01755666173994541,
-0.0058356658555567265,
-0.02159196324646473,
0.033673033118247986,
-0.036702610552310944,
0.0458906814455986,
0.017569078132510185,
0.049317583441734314,
-0.05979694798588753,
-0.01403043046593666,
-0.02249835431575775,
-0.013422030955553055,
-0.0049385870806872845,
0.001444171997718513,
-0.00046056750579737127,
0.015147898346185684,
-0.009709554724395275,
-0.003097869222983718,
0.021132560446858406,
-0.0015667830593883991,
0.036056965589523315,
-0.007009007036685944,
0.02974947914481163,
0.027936697006225586,
0.012223857454955578,
-0.03335020691156387,
-0.0065371873788535595,
0.013471696525812149,
-0.00844929926097393,
-0.02467120811343193,
-0.09903249144554138,
0.04608934372663498,
0.010566280223429203,
-0.011013266630470753,
-0.006065367255359888,
-0.02905416488647461,
-0.014527082443237305,
0.017705658450722694,
-0.019332194700837135,
0.05214850232005119,
0.06421715766191483,
0.018289225175976753,
-0.011932074092328548,
-0.009529517963528633,
0.014638829044997692,
-0.0014302036724984646,
0.008778330869972706,
-0.0300226379185915,
-0.012099694460630417,
0.04566718637943268,
-0.01734558492898941,
0.0004908322589471936,
-0.017854653298854828,
-0.006052951328456402,
0.04740547016263008,
0.026993058621883392,
0.024410465732216835,
-0.04792695492506027,
-0.05150285363197327,
0.0405765026807785,
0.008747290819883347,
0.03647911921143532,
0.018028482794761658,
-0.05552573874592781,
0.01682410016655922,
0.005602859891951084,
0.02280876226723194,
0.00848033931106329,
0.03697577118873596,
0.013893851079046726,
0.02318125031888485,
-0.03568447381258011,
-0.016426777467131615,
0.027142053470015526,
0.017953984439373016,
-0.027688371017575264,
0.02221277914941311,
0.03958319500088692,
-0.013521361164748669,
0.03141326457262039,
-0.018400970846414566,
0.011112597770988941,
-0.006381983403116465,
0.007375288289040327,
-0.023466825485229492,
0.009169444441795349,
-0.015619717538356781,
0.03672744333744049,
0.008753498084843159,
0.009790260344743729,
-0.04079999402165413,
0.021778207272291183,
-0.011466462165117264,
-0.03585830330848694,
0.017668409273028374,
0.004634387791156769,
-0.05269481986761093,
0.008070601150393486,
0.054433103650808334,
-0.06774339079856873,
-0.004289835225790739,
-0.008784539066255093,
0.02446013130247593,
-0.015545220114290714,
-0.017283502966165543,
-0.023193666711449623,
-0.02114497497677803,
0.038192570209503174,
0.01285088062286377,
-0.040551669895648956,
-0.016848932951688766,
-0.027166886255145073,
0.045170534402132034,
-0.01945635676383972,
-0.026893727481365204,
0.029103830456733704,
-0.005680461879819632,
0.0414704754948616,
-0.01730833575129509,
-0.02950115315616131,
0.04094899073243141,
0.0021402614656835794,
0.013074374757707119,
-0.0075615327805280685,
0.011211927980184555,
0.00024716215557418764,
0.05334046855568886,
-0.00002868846604542341,
-0.004218441434204578,
0.04196712747216225,
-0.013744855299592018,
0.012447350658476353,
-0.00554698659107089,
-0.02393864467740059,
0.011689955368638039,
-0.01285088062286377,
0.014489833265542984,
-0.0331018827855587,
0.02159196324646473,
-0.02010200545191765,
0.0032685936894267797,
0.005214849952608347,
-0.01473816018551588,
0.024609126150608063,
0.0229453407227993,
0.03347437083721161,
0.03893754631280899,
0.07896772772073746,
-0.0023327141534537077,
0.04864710196852684,
0.043928906321525574,
0.04308459535241127,
-0.012205232866108418,
0.03071795031428337,
-0.007580157369375229,
-0.009672305546700954,
-0.017420083284378052,
0.0010895312298089266,
-0.01655094139277935,
0.0018407179741188884,
-0.00020409309945534915,
-0.007220084313303232,
0.040030185133218765,
0.004687156993895769,
0.006891052238643169,
-0.0008443090482614934,
-0.01337236538529396,
-0.00733183091506362,
-0.041445642709732056,
-0.0017538038082420826,
-0.02277151308953762,
-0.05085720494389534,
0.020859399810433388,
0.004379853140562773,
0.028358852490782738,
0.03876372054219246,
-0.012292146682739258,
-0.011193303391337395,
-0.012950210832059383,
0.002053347183391452,
-0.03714960068464279,
-0.022399023175239563,
-0.006742056459188461,
-0.03675227612257004,
-0.011559584178030491,
-0.009268775582313538,
-0.00033659840119071305,
0.0331018827855587,
0.017978817224502563,
-0.008660376071929932,
0.022821176797151566,
0.011211927980184555,
0.03935970366001129,
-0.01096981018781662,
0.018910039216279984,
0.012397685088217258,
-0.008505172096192837,
-0.02218794636428356,
-0.01841338723897934,
-0.0015985999489203095,
0.032630063593387604,
-0.047554466873407364,
-0.006015702150762081,
-0.002324954140931368,
-0.004628179594874382,
-0.022175529971718788,
0.024236636236310005,
0.01435325387865305,
0.009746802970767021,
-0.014539498835802078,
-0.04839877784252167,
0.0060188062489032745,
-0.0018717587227001786,
0.005733231082558632,
-0.034989163279533386,
-0.030246131122112274,
0.06630309671163559,
0.005062750540673733,
-0.03265489637851715,
0.017978817224502563,
0.017258670181035995,
0.0161287859082222,
0.012664636597037315,
-0.023541323840618134,
-0.014601580798625946,
0.014489833265542984,
-0.034393180161714554,
0.011187095195055008,
-0.010361410677433014,
-0.05368812382221222,
-0.00019429584790486842,
0.026769563555717468,
0.0183140579611063,
-0.011149846017360687,
0.012912962585687637,
0.011882408522069454,
-0.04802628606557846,
0.03560997545719147,
-0.002812294289469719,
0.001033657812513411,
-0.01959293708205223,
0.012652220204472542,
0.03372269868850708,
-0.00658064428716898,
0.0005843425751663744,
-0.01442775223404169,
-0.016178451478481293,
0.05597272515296936,
-0.012962627224624157,
-0.04211612418293953,
-0.02432355098426342,
-0.01945635676383972,
0.015594885684549809,
0.02860717847943306,
-0.008089225739240646,
-0.013508944772183895,
-0.0023063295520842075,
0.010460740886628628,
-0.012552889063954353,
-0.01136713195592165,
-0.018512718379497528,
-0.006090200040489435,
-0.0348898321390152,
-0.004628179594874382,
-0.01969226822257042,
-0.01602945663034916,
0.037745583802461624,
-0.04936724901199341,
0.006506146397441626,
-0.011360923759639263,
0.00849896389991045,
-0.02376481704413891,
0.016600606963038445,
-0.0768321231007576,
-0.043928906321525574,
0.022125864401459694,
0.024261469021439552,
-0.012118318118155003,
0.04228994995355606,
-0.027415212243795395,
0.00016888121899683028,
-0.015334142372012138,
0.011882408522069454,
0.020325498655438423,
-0.03459183871746063,
0.004913754761219025,
0.03454217314720154,
-0.037844911217689514,
-0.002109220717102289,
0.001815885305404663,
0.005388678517192602,
-0.021616796031594276,
-0.051949840039014816,
-0.012900546193122864,
0.014328422024846077,
-0.019493605941534042,
0.02256043441593647,
-0.0370502695441246,
0.015669383108615875,
0.006990382447838783,
0.06218088045716286,
0.07484551519155502,
-0.04184296354651451,
-0.004013572353869677,
-0.008567254059016705,
-0.015470721758902073,
-0.04695848375558853,
0.02263493277132511,
0.05175118148326874,
-0.013260618783533573,
-0.007381496485322714,
0.014278756454586983,
0.05055921524763107,
0.00040003799949772656,
-0.015868043527007103,
0.02393864467740059,
0.012459767051041126,
0.015954958274960518,
0.018363721668720245,
-0.00984613411128521,
-0.04430139437317848,
0.0025903526693582535,
0.01782982051372528,
0.005705294199287891,
-0.03243140131235123,
-0.026645401492714882,
-0.013831769116222858,
0.03372269868850708,
0.008666584268212318,
0.01593012548983097,
0.001492285286076367,
0.004687156993895769,
0.033052217215299606,
-0.010187582112848759,
0.013384781777858734,
-0.004019780550152063,
-0.01138575654476881,
0.00818855594843626,
-0.007673279382288456,
-0.011671331711113453,
-0.001955568790435791,
-0.06699840724468231,
0.05686669796705246,
0.03181058540940285,
-0.024385632947087288,
-0.004128423053771257,
0.031462930142879486,
-0.020909065380692482,
-0.015880459919571877,
-0.03975702449679375,
0.034989163279533386,
0.0348898321390152,
-0.005494216922670603,
-0.016116369515657425,
0.003991843666881323,
-0.006205050740391016,
-0.016116369515657425,
0.005860498175024986,
0.008697625249624252,
0.029873641207814217,
-0.0017243149923160672,
0.014762992970645428,
0.03903687745332718,
0.007940229959785938,
-0.03203408047556877,
-0.015669383108615875,
0.028036028146743774,
0.03749725595116615,
-0.04017917811870575,
0.08323894441127777,
-0.02632257714867592,
-0.005460072308778763,
0.008815580047667027,
-0.014874739572405815,
-0.005252099130302668,
-0.008157515898346901,
0.005158976651728153,
0.02280876226723194,
-0.003001642879098654,
-0.014291172847151756,
-0.017780154943466187,
0.006264028139412403,
0.0264964047819376,
-0.07474618405103683,
-0.024919534102082253,
-0.01676201820373535,
-0.003759037936106324,
0.032456234097480774,
0.004606450907886028,
0.02044966258108616,
0.00368454004637897,
-0.0010297776898369193,
0.02657090313732624,
0.009523309767246246,
-0.014514666050672531,
-0.002843335038051009,
-0.0060343267396092415,
-0.03769591823220253,
0.000005504887212737231,
0.016190867871046066,
-0.018189894035458565,
-0.03109044022858143,
-0.02221277914941311,
0.023106751963496208,
-0.0004132303292863071,
0.014874739572405815,
0.011429212987422943,
0.02300742268562317,
0.01720900647342205,
0.011522335931658745,
0.007518075872212648,
0.012155567295849323,
-0.002779701491817832,
-0.016488859429955482,
0.008163724094629288,
-0.011354715563356876,
0.011044307611882687,
0.026719899848103523,
0.0072387089021503925,
-0.009411563165485859,
-0.009721971116960049,
0.0032592813950031996,
0.007201459724456072,
0.02321849949657917,
-0.0050286054611206055,
-0.023814482614398003,
-0.006884844042360783,
0.010249664075672626,
-0.012739134021103382,
-0.029550816863775253,
-0.034666337072849274,
0.014986486174166203,
-0.00013822845357935876,
0.01145404577255249,
-0.025825925171375275,
-0.0004225425363983959,
-0.01101947482675314,
0.0033182587940245867,
0.03459183871746063,
-0.11462737619876862,
-0.026173582300543785,
-0.012217649258673191,
-0.02639707550406456,
0.005280036013573408,
0.0034641504753381014,
-0.020412413403391838,
0.016613023355603218,
0.01442775223404169,
-0.019977843388915062,
0.021269138902425766,
-0.026620568707585335,
0.019133534282445908,
-0.023727567866444588,
0.017680825665593147,
-0.04323359206318855,
-0.008958367630839348,
-0.0205241609364748,
-0.027067555114626884,
0.02321849949657917,
0.015309310518205166,
-0.004898234270513058,
0.013347533531486988,
0.04407789930701256,
-0.018475469201803207,
-0.02093389816582203,
-0.00010485961684025824,
-0.02308192104101181,
-0.020884232595562935,
0.021219473332166672,
0.0156569667160511,
-0.002807638142257929,
-0.052943143993616104,
0.0419422946870327,
0.005326597020030022,
-0.021716125309467316,
0.018264392390847206,
-0.014129760675132275,
0.012776383198797703,
0.022995006293058395,
0.009858550503849983,
0.0088279964402318,
0.03486499935388565,
-0.0021138768643140793,
0.0018593424465507269,
-0.007443577982485294,
0.004562993999570608,
-0.032282404601573944,
0.01435325387865305,
0.003336883382871747,
0.0066116852685809135,
-0.026372242718935013,
-0.046238336712121964,
0.013608275912702084,
0.004892026074230671,
0.005879122763872147,
-0.03707510232925415,
0.0326797291636467,
0.03921070694923401,
-0.0027409004978835583,
-0.0042929393239319324,
0.00659926887601614,
0.021442966535687447,
0.026695067062973976,
-0.029873641207814217,
-0.013893851079046726,
0.013347533531486988,
0.018698962405323982,
-0.054333772510290146,
0.021442966535687447,
-0.016265366226434708,
0.008666584268212318,
-0.0706239715218544,
0.00832513626664877,
0.01806573010981083,
-0.021020812913775444,
0.015383807942271233,
-0.03161192685365677,
-0.006897259969264269,
0.019816430285573006,
0.0019090076675638556,
-0.036330122500658035,
-0.015868043527007103,
-0.0006367238820530474,
-0.006711015477776527,
-0.01043590810149908,
-0.0017801884096115828,
-0.007524283602833748,
-0.007126961834728718,
-0.004640595987439156,
-0.002880583982914686,
0.008374800905585289,
0.0052272663451731205,
-0.005931891966611147,
-0.009355689398944378,
0.0021573337726294994,
-0.015669383108615875,
0.02193962037563324,
-0.0023125377483665943,
0.0000972449270193465,
0.03109044022858143,
-0.028557512909173965,
0.017358001321554184,
-0.009852342307567596,
-0.029600482434034348,
-0.02411247417330742,
0.022485937923192978,
-0.04117248207330704,
0.007176626939326525,
-0.002383931539952755,
0.021293971687555313,
-0.00891491025686264,
0.026272911578416824,
0.014142177067697048,
0.019083868712186813,
0.00042642265907488763,
0.020015092566609383,
-0.01951843872666359,
-0.013782104477286339,
0.012987460009753704,
0.04350674897432327,
0.021219473332166672,
-0.044450391083955765,
-0.013347533531486988,
-0.006211258936673403,
-0.012999876402318478,
0.02308192104101181,
0.05706536024808884,
0.02287084236741066,
-0.008089225739240646,
0.0018841749988496304,
0.019431525841355324,
0.004547473508864641,
0.02411247417330742,
0.014527082443237305,
-0.002432044595479965,
0.0300226379185915,
0.03600730001926422,
-0.011491294950246811,
0.012062445282936096,
0.010510406456887722,
0.01207486167550087,
0.003979427274316549,
0.0169979277998209,
0.03583347052335739,
0.025999752804636955,
-0.05438343808054924,
0.04484771192073822,
-0.019717101007699966,
0.009771635755896568,
0.003197199897840619,
-0.0016917221946641803,
0.023019839078187943,
0.06367083638906479,
-0.01979159750044346,
0.0066116852685809135,
0.008486547507345676,
-0.016563357785344124,
-0.006897259969264269,
0.01761874370276928,
-0.01624053344130516,
0.04273694008588791,
-0.04564235359430313,
-0.0287065077573061,
-0.009510893374681473,
-0.0019431525142863393,
-0.008008520118892193,
-0.01817747764289379,
0.009579183533787727,
0.023057088255882263,
0.0008512932690791786,
-0.07653413712978363,
0.05949895828962326,
-0.022274859249591827,
0.003150638658553362,
0.010609736666083336,
0.03158709406852722,
-0.004147047642618418,
0.019717101007699966,
0.028110526502132416,
-0.02197686769068241,
0.02860717847943306,
0.018636880442500114,
0.047802794724702835,
0.031835418194532394,
-0.015197562985122204,
-0.0019741933792829514,
-0.02788703143596649,
-0.0053017642349004745,
-0.005562507081776857,
0.0008311167475767434,
-0.01212452631443739,
0.013670356944203377,
0.0463625006377697,
0.05155251920223236,
-0.008728666231036186,
-0.009455019608139992,
0.020263418555259705,
-0.03682677447795868,
-0.021207056939601898,
-0.017879486083984375,
0.0449967086315155,
0.046759821474552155,
0.016178451478481293,
-0.015334142372012138,
0.0034548381809145212,
0.0449967086315155,
-0.033772364258766174,
-0.038366395980119705,
0.07251124829053879,
-0.017457332462072372,
0.019332194700837135,
-0.038987211883068085,
0.009492268785834312,
0.011509919539093971,
-0.018251975998282433,
0.004817528184503317,
-0.013384781777858734,
-0.002267528558149934,
-0.03054412268102169,
-0.03958319500088692,
-0.03292805328965187,
0.004826840478926897,
-0.01579354703426361,
0.030693117529153824,
0.031115273013710976,
0.005789104383438826,
0.020275834947824478,
-0.026446741074323654,
0.00886524561792612,
-0.02097114734351635,
0.04102348908782005,
0.006711015477776527,
0.01723383739590645,
-0.022846009582281113,
-0.0308917798101902,
0.012583930045366287,
-0.009678513742983341,
0.0024413568899035454,
-0.022299692034721375,
0.05199950560927391,
0.031909916549921036,
-0.008051976561546326,
0.010299328714609146,
-0.011305049993097782,
-0.011547168716788292,
0.03814290463924408,
-0.014812657609581947,
0.0024925742764025927,
-0.010808398015797138,
-0.02612391673028469,
0.003945282660424709,
0.00730699859559536,
0.020822152495384216,
0.01854996755719185,
0.011503711342811584,
-0.006012598052620888,
-0.011838951148092747,
0.02595008723437786,
0.0009413114748895168,
-0.016488859429955482,
-0.02525477483868599,
0.012360436841845512,
0.005087582860141993,
0.012633595615625381,
-0.02062349021434784,
0.011857575736939907,
-0.02763870544731617,
0.03195958212018013,
-0.008716249838471413,
0.0011353163281455636,
0.012683260254561901,
-0.025801092386245728,
-0.004339500330388546,
-0.0005692102131433785,
-0.025229942053556442,
0.030966276302933693,
-0.03387169539928436,
0.0025841444730758667,
0.003218928351998329,
0.01439050305634737,
-0.016712352633476257,
-0.03849055990576744,
0.011373340152204037,
0.021740958094596863,
0.025652095675468445,
-0.012403893284499645,
-0.026595735922455788,
-0.0047989035956561565,
-0.027762869372963905,
-0.04079999402165413,
0.024273885414004326,
-0.02028825134038925,
-0.0030233715660870075,
-0.007418745197355747,
-0.03339987248182297,
-0.02393864467740059,
-0.011280217207968235,
0.020784903317689896,
-0.006990382447838783,
0.028458181768655777,
0.002433596644550562,
-0.006310589611530304,
0.0026276016142219305,
-0.02042482979595661,
-0.04514570161700249,
-0.04492221027612686,
-0.02719171904027462,
0.03777041658759117,
0.004789591766893864,
-0.031289100646972656,
0.01585562713444233,
-0.003880096832290292,
0.01532172691076994,
0.00695313373580575,
-0.007983687333762646,
-0.047455135732889175,
0.01696067862212658,
0.01368277333676815,
-0.006437856703996658,
-0.0018639984773471951,
0.017295919358730316,
0.0031847835052758455,
-0.02632257714867592,
-0.03275422379374504,
-0.002411868190392852,
-0.002368411049246788,
-0.006903468165546656,
-0.005419719498604536,
-0.004805111791938543,
-0.02218794636428356,
0.004472975619137287,
0.007375288289040327,
-0.0001685902097960934,
-0.003740413347259164,
0.02180304005742073,
0.014489833265542984,
-0.024683624505996704,
0.008803163655102253,
0.003526231972500682,
-0.006130552850663662,
-0.010907728224992752,
0.019915761426091194,
0.017879486083984375,
0.021914787590503693,
0.0047057815827429295,
0.02940182201564312,
0.02259768359363079,
-0.02657090313732624,
0.010386243462562561,
0.06153523176908493,
-0.006354046519845724,
-0.005972245242446661,
0.03806840628385544,
0.002002130029723048,
-0.005702190566807985,
0.011050515808165073,
-0.005807728972285986,
-0.004833048675209284,
0.00034183653770014644,
-0.022622516378760338,
0.042339615523815155,
0.020015092566609383,
-0.0028743757866322994,
0.0027083077002316713,
0.00027820293325930834,
-0.03590796887874603,
0.003721788991242647,
-0.00813889130949974,
0.022436272352933884,
0.005699086468666792,
0.026595735922455788,
-0.001385194598697126,
-0.006012598052620888,
-0.01709725894033909,
0.014800241217017174,
0.03126426786184311,
0.011441629379987717,
-0.032903220504522324,
-0.012087278068065643,
0.008784539066255093,
0.01817747764289379,
0.017593910917639732,
-0.0034486299846321344,
-0.009070114232599735,
-0.018189894035458565,
0.012174191884696484,
-0.03019646555185318,
0.001197397941723466,
0.019853679463267326,
0.02791186422109604,
-0.008157515898346901,
0.015073399990797043,
-0.0016374008264392614,
-0.006056054960936308,
0.00406944565474987,
-0.004348812624812126,
0.010733899660408497,
-0.014825074002146721,
0.01328545156866312,
-0.03141326457262039,
-0.03163675591349602,
0.019530855119228363,
-0.0035852096043527126,
-0.004004260059446096,
0.008337551727890968,
-0.01837613806128502,
-0.0031087335664778948,
-0.007580157369375229,
0.025130610913038254,
-0.026347409933805466,
0.03223273903131485,
-0.03414485231041908,
0.008623126894235611,
-0.01581837795674801,
-0.0004155583737883717,
-0.02176579087972641,
0.010957393795251846,
0.006350942421704531,
-0.008045769296586514,
-0.0102620804682374,
0.016501275822520256,
-0.009008033201098442,
0.0405765026807785,
0.0013052645372226834,
0.006040534935891628,
0.005857394076883793,
0.03027096390724182,
-0.03188508376479149,
0.00480200769379735,
-0.0038428478874266148,
-0.012043820694088936,
0.02411247417330742,
0.014018014073371887,
-0.04422689601778984,
0.010690443217754364,
0.0014216675190255046,
-0.0004365108907222748,
-0.03749725595116615,
0.03585830330848694,
-0.0021138768643140793,
0.03193474933505058,
0.0007174299098551273,
0.009219110012054443,
0.002127845073118806,
-0.004389165434986353,
-0.01982884667813778,
0.015470721758902073,
0.023516491055488586,
0.02930249087512493,
-0.011286425404250622,
-0.012304563075304031,
-0.006866219453513622,
-0.0012292147148400545,
-0.0035603768192231655,
0.004038404673337936,
-0.03511332347989082,
-0.039781857281923294,
0.023131584748625755,
-0.00045047924504615366,
-0.0078098587691783905,
-0.010106876492500305,
-0.005553194787353277,
0.023230915889143944,
0.013210954144597054,
-0.01775532402098179,
0.01751941256225109,
0.00766086345538497,
-0.029699813574552536,
-0.000961487996391952,
0.01105672400444746,
0.025627262890338898,
0.0076111978851258755,
-0.009150820784270763,
-0.009088738821446896,
-0.0010600424138829112,
0.026819229125976562,
0.011925865896046162,
-0.004743030294775963,
-0.0022256234660744667,
-0.033325374126434326,
0.0087224580347538,
0.009709554724395275,
0.0018515822011977434,
0.0353119857609272,
-0.0006107272347435355,
-0.008356176316738129,
-0.035361651331186295,
0.06729640066623688,
0.028458181768655777,
0.000066931672336068,
0.025267191231250763,
-0.0017165548633784056,
-0.01212452631443739,
0.024211805313825607,
0.02162921242415905,
0.002304777503013611,
-0.030792448669672012,
-0.012726717628538609,
0.00296284188516438,
-0.03414485231041908,
0.03054412268102169,
-0.007940229959785938,
0.012534264475107193,
0.017854653298854828,
0.016923431307077408,
-0.04253827780485153,
-0.055575404316186905,
0.01297504361718893,
-0.0103676188737154,
-0.00034901470644399524,
-0.006406815722584724,
0.0036193544510751963,
0.002844887087121606,
0.04310942813754082,
0.026421908289194107,
-0.004817528184503317,
0.03126426786184311,
0.022883258759975433,
-0.014986486174166203,
-0.015234812162816525,
0.027489710599184036,
-0.029898473992943764,
-0.026421908289194107,
-0.024211805313825607,
-0.0406261645257473,
-0.01403043046593666,
0.013310284353792667,
-0.015731465071439743,
0.031189771369099617,
0.042960431426763535,
-0.004792695865035057,
0.028830671682953835,
-0.0370999351143837,
-0.014253923669457436,
0.07002798467874527,
-0.016873765736818314,
-0.01761874370276928,
-0.013434447348117828,
0.0070586721412837505,
-0.022374190390110016,
0.00776640186086297,
0.016091538593173027,
0.016215700656175613,
0.0161287859082222,
0.02021375298500061,
0.029153496026992798,
0.0205241609364748,
-0.006350942421704531,
-0.015954958274960518,
0.008070601150393486,
0.008834204636514187,
-0.018127812072634697,
0.026595735922455788,
-0.0032003039959818125,
-0.036330122500658035,
-0.0273655466735363,
0.025366520509123802,
-0.012633595615625381,
0.019083868712186813,
-0.015160314738750458,
-0.007139378227293491,
0.026347409933805466,
0.04805111885070801,
0.011286425404250622,
-0.021306388080120087,
-0.03335020691156387,
0.016054289415478706,
-0.03804357349872589,
0.027440045028924942,
-0.007089713122695684,
0.007648447062820196,
0.013794519938528538,
-0.029774311929941177,
-0.00808301754295826,
0.05483042448759079,
-0.015470721758902073,
-0.015358975157141685,
-0.018189894035458565,
-0.007095921318978071,
-0.014551915228366852,
-0.018264392390847206,
-0.01630261540412903,
0.01132988277822733,
0.012565305456519127,
-0.017060009762644768,
-0.015868043527007103,
0.00043845095206052065,
-0.028557512909173965,
0.016948262229561806,
-0.015085816383361816,
-0.0028278145473450422,
0.02771320380270481,
-0.0011896376963704824,
-0.008945951238274574,
0.007549116387963295,
-0.007145586423575878,
0.015830794349312782,
-0.02110772766172886,
-0.012565305456519127,
0.013049541972577572,
0.0063571506179869175,
0.022858425974845886,
-0.023417159914970398,
-0.0013688981998711824,
-0.007909188978374004,
-0.001181877451017499,
-0.011590625159442425,
-0.0029240408912301064,
-0.011025683023035526,
0.006251612212508917,
-0.02484503574669361,
-0.011987946927547455,
0.01513548195362091,
0.01209348626434803,
0.0344180129468441,
-0.02691856026649475,
-0.014862323179841042,
0.02905416488647461,
-0.011987946927547455,
0.005553194787353277,
0.04954107850790024,
-0.013893851079046726,
0.0249443668872118,
-0.02967498078942299,
0.022982589900493622,
0.0005009205196984112,
0.0027129636146128178,
0.013508944772183895,
0.01031174510717392,
0.0036348747089505196,
0.030519289895892143,
0.028284354135394096,
-0.018649296835064888,
-0.024410465732216835,
-0.0013533778255805373,
-0.025652095675468445,
-0.006220571231096983,
-0.03374753147363663,
0.004407790023833513,
-0.03081728145480156,
0.03260523080825806,
-0.020995980128645897,
-0.000602967047598213,
-0.03302738443017006,
-0.0023156418465077877,
-0.02639707550406456,
-0.015979791060090065,
0.0011787734692916274,
-0.001671545673161745,
-0.03387169539928436,
0.027241384610533714,
-0.005550090689212084,
0.01889762282371521,
0.019083868712186813,
0.019617769867181778,
-0.0031692630145698786,
0.030047470703721046,
-0.018872791901230812,
-0.012379061430692673,
0.0063416301272809505,
-0.007232500705868006,
-0.008349968120455742,
0.022572850808501244,
-0.016749601811170578,
0.01355861034244299,
0.009014241397380829,
0.010752524249255657,
-0.016364697366952896,
-0.017916735261678696,
-0.019679851830005646,
0.013148872181773186,
-0.030866947025060654,
0.012428726069629192,
0.08860278874635696,
-0.006915884558111429,
-0.000051556788093876094,
0.00668618269264698,
0.016811683773994446,
-0.005385574419051409,
0.0022597683127969503,
-0.010926352813839912,
0.009529517963528633,
0.005438343621790409,
-0.03965769335627556,
0.02632257714867592,
0.016041873022913933,
0.038639556616544724,
0.028756173327565193,
-0.025453435257077217,
0.004494704306125641,
0.028383685275912285,
-0.019183197990059853,
-0.0054818009957671165,
-0.005851185880601406,
0.014229090884327888,
-0.037646252661943436,
-0.0034548381809145212,
-0.0200771726667881,
-0.026446741074323654,
-0.019816430285573006,
-0.03046962432563305,
-0.008455507457256317,
0.004221545532345772,
0.016401944682002068,
0.012192816473543644,
-0.030444791540503502,
-0.018425803631544113,
0.017047593370079994,
-0.0007639910909347236,
-0.028458181768655777,
-0.0065371873788535595,
-0.03292805328965187,
0.04643699899315834,
0.022883258759975433,
-0.0013231129851192236,
-0.006791721563786268,
0.015470721758902073,
0.011671331711113453,
0.0009754563216120005,
-0.03215824440121651,
0.023417159914970398,
0.030593788251280785,
0.025006448850035667,
0.02905416488647461,
-0.015123065561056137,
0.009175652638077736,
-0.0033058426342904568,
0.01430358923971653,
-0.020784903317689896,
-0.01633986458182335,
0.01637711189687252,
0.0059101637452840805,
-0.04027850925922394,
-0.0322079062461853,
0.0056214844807982445,
0.017705658450722694,
0.004249481949955225,
0.0053328052163124084
] | 2025-01-08 | 54 | 39775969 | [
"mutant CALR",
"CALR",
"targeted therapies",
"mutant CALR-directed vaccines",
"mehanistic understanding",
"mechanistic understanding",
"CALR-mutant MPN",
"MPN",
"preclinical models",
"therapeutic targeting",
"chimeric antigen receptor",
"the mutant CALR-MPL complex",
"the mutant CALR C-terminus",
"discovery",
"early clinical trials",
"recent advances",
"myeloproliferative neoplasms",
"Approaches",
"Structural insights",
"proteasome",
"Calreticulin",
"drivers",
"the leading therapeutic approach",
"Calreticulin (CALR) mutations",
"N-glycosylation pathways",
"evaluation",
"the unfolded protein response",
"patients",
"MPL-JAK-STAT activation",
"the cell surface"
] | [] | 0 | 10.1007/s11899-024-00749-4
10.1111/joim.13019
10.1016/S0140-6736(05)71142-9
10.1038/nature03546
10.1016/j.ccr.2005.03.023
10.1056/NEJMoa051113
10.1056/NEJMoa1311347
10.1056/NEJMoa1312542
10.1371/journal.pmed.0030270
10.1038/leu.2014.3
10.1182/blood-2016-10-695940
10.1128/MCB.25.20.8844-8853.2005
10.1042/BJ20081847
10.1038/leu.2015.277
10.1182/blood-2015-11-681932
10.1182/blood-2015-09-671172
10.1182/blood-2015-11-679571
10.1158/2159-8290.CD-15-1434
10.1038/leu.2016.32
10.1002/ajh.26171
10.1038/s41375-018-0181-2
10.1182/blood-2017-08-800896
10.1182/blood-2018-09-874578
10.1038/s41467-023-37277-3
10.1056/NEJMoa1716614
10.1038/s41586-019-1367-0
10.1073/pnas.2120374119
10.1182/blood.2019000428
10.1038/s41375-023-01837-9
10.1182/blood-2012-05-432989
10.1182/blood.2020005563
10.1038/s41375-018-0295-6
10.1182/blood.2021010986
10.1182/bloodadvances.2021004856
10.1182/blood-2020-141159
10.3390/ijms23126803
10.15252/embr.202152904
10.1182/blood-2023-173430
10.1158/2159-8290.CD-18-1356
10.1002/ajh.27428
10.1186/s13045-016-0275-0
10.1080/2162402X.2019.1708126
10.1038/s41375-019-0564-z
10.1182/blood.2022016846
10.1038/leu.2016.233
10.1038/leu.2017.214
10.1038/s41408-018-0166-4
10.1126/scitranslmed.aba4380
10.3389/fonc.2021.637420
10.1016/j.leukres.2016.02.004
10.1182/blood-2020-137294
10.1158/2643-3230.BCD-21-0144
10.1038/s41375-022-01781-0
10.1182/blood-2016-02-696310
10.1007/978-3-030-67696-4_7
10.1016/j.celrep.2022.111689
10.1093/ajcp/aqw005
10.1182/blood.2022015629 | [
"Faiz",
"Riedemann",
"Jutzi",
"Mullally"
] | [
"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA.",
"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA.",
"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, MA, 02115, USA.",
"Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. [email protected].\nHematology Division, VA Palo Alto Health Care System, Palo Alto, CA, 94304, USA. [email protected]."
] | [
"39775969",
"31927786",
"15781101",
"15793561",
"15837627",
"15858187",
"24325356",
"24325359",
"16834459",
"24402162",
"28028029",
"19133842",
"26449662",
"26668133",
"26817954",
"26608331",
"26951227",
"26883579",
"33761144",
"29946189",
"29288169",
"30902807",
"37019903",
"30304655",
"31270458",
"36083966",
"31515250",
"36828867",
"23487027",
"33667305",
"30470838",
"34407546",
"34507355",
"35743246",
"35156745",
"31266769",
"38953347",
"27177927",
"32002304",
"31462733",
"36356299",
"27560107",
"28676668",
"30655510",
"35704596",
"33718228",
"26943702",
"35405004",
"36473980",
"27013444",
"34050865",
"36417879",
"27124925",
"35763665"
] | [] | 6.711076 | 7.163279 |
39775044 | 60 | Intracerebroventricular B7-H3-targeting CAR T cells for diffuse intrinsic pontine glioma: a phase 1 trial. | Diffuse intrinsic pontine glioma (DIPG) is a fatal central nervous system (CNS) tumor that confers a median survival of 11 months. As B7-H3 is expressed on pediatric CNS tumors, we conducted BrainChild-03, a single-center, dose-escalation phase 1 clinical trial of repetitive intracerebroventricular (ICV) dosing of B7-H3-targeting chimeric antigen receptor T cells (B7-H3 CAR T cells) for children with recurrent or refractory CNS tumors and DIPG. Here we report results from Arm C, restricted to patients with DIPG. The primary objectives were to assess feasibility and tolerability, which were both met. Secondary objectives included assessments of CAR T cell distribution and survival. A total of 23 patients with DIPG enrolled, and 21 were treated with repeated doses of ICV B7-H3 CAR T cells using intra-patient dose-escalation regimens without previous lymphodepletion. Concurrent tumor-directed therapy, including re-irradiation, was not allowed while on protocol therapy. We delivered a total of 253 ICV doses and established the highest planned dose regimen, DR4, which escalated up to 10 × 10 | [
-0.004917621612548828,
0.024824917316436768,
0.04502437636256218,
0.0764184221625328,
-0.039734628051519394,
-0.04079257696866989,
-0.025243176147341728,
0.04982205852866173,
0.00982294138520956,
-0.03200913220643997,
0.005812573246657848,
0.003029304090887308,
-0.03744650259613991,
-0.011022360995411873,
0.019055400043725967,
-0.021097488701343536,
0.05230700969696045,
-0.02251218818128109,
-0.001328588230535388,
0.03678220883011818,
0.010868589393794537,
0.02568603865802288,
0.006538376212120056,
-0.004262553993612528,
0.00549272820353508,
-0.006003250367939472,
0.040595751255750656,
0.004926847759634256,
0.023410215973854065,
-0.041678301990032196,
0.02760511077940464,
-0.008469750173389912,
-0.04172750934958458,
-0.012412458658218384,
0.0026771666016429663,
-0.013261278159916401,
-0.004370193928480148,
0.07021834701299667,
-0.043892618268728256,
0.000627388886641711,
0.00365669303573668,
-0.020531607791781425,
0.019166115671396255,
0.06603575497865677,
-0.06583892554044724,
-0.00624928530305624,
-0.009989014826714993,
-0.03744650259613991,
0.03845524787902832,
0.027629714459180832,
-0.024874122813344002,
0.037544917315244675,
-0.011668202467262745,
0.06549447774887085,
-0.040005266666412354,
0.0587531216442585,
-0.004354816861450672,
0.003084661904722452,
-0.005554236937314272,
-0.012184876017272472,
0.017357759177684784,
-0.018895477056503296,
0.0395624041557312,
-0.023557836189866066,
-0.04239180311560631,
0.012197177857160568,
-0.06800403445959091,
-0.013347391039133072,
0.03282104805111885,
0.028170989826321602,
-0.003438337007537484,
0.0072764805518090725,
-0.017825225368142128,
-0.036733001470565796,
0.04903474450111389,
0.0058894590474665165,
0.009921355172991753,
-0.06072140112519264,
0.000861121981870383,
-0.011821975000202656,
0.016951801255345345,
0.017185533419251442,
0.010050524026155472,
-0.049920469522476196,
-0.03572425991296768,
-0.030286889523267746,
0.00789771880954504,
-0.009306267835199833,
-0.03183690831065178,
-0.03476472571492195,
-0.015192652121186256,
-0.03279644623398781,
-0.06761037558317184,
0.03712666034698486,
-0.015352575108408928,
-0.03574886545538902,
0.0114652244374156,
-0.06037695333361626,
-0.00014944694703444839,
0.015500195324420929,
-0.010751723311841488,
0.009509246796369553,
-0.002569526433944702,
0.02195861004292965,
0.05036333203315735,
0.031664684414863586,
-0.05388163402676582,
0.03139404579997063,
0.0307297520339489,
-0.0032845651730895042,
0.06391985714435577,
0.021048281341791153,
-0.007319536991417408,
0.05712929368019104,
-0.005403540562838316,
-0.01840340718626976,
-0.008937216363847256,
-0.03806159272789955,
0.0016714992234483361,
0.041801322251558304,
-0.03909493610262871,
0.023028861731290817,
-0.000991828041151166,
-0.054029252380132675,
0.03269803151488304,
-0.03176309913396835,
0.07740256190299988,
-0.045245807617902756,
-0.0139378746971488,
-0.05880232900381088,
-0.006759807467460632,
-0.022745922207832336,
0.05132286995649338,
-0.03456789627671242,
-0.030163872987031937,
-0.004862263798713684,
-0.020420892164111137,
-0.009416983462870121,
-0.03909493610262871,
-0.03033609688282013,
-0.010191993787884712,
0.003970387391746044,
0.00886340532451868,
-0.01305214874446392,
0.01975659839808941,
-0.012215630151331425,
-0.021909402683377266,
0.054029252380132675,
0.02760511077940464,
0.02854004316031933,
-0.041383061558008194,
0.03579806908965111,
0.04679583013057709,
-0.02580905519425869,
0.001321668503805995,
-0.026891609653830528,
-0.0189569853246212,
0.05398004502058029,
-0.01938754692673683,
-0.0587531216442585,
-0.040571145713329315,
0.01755458675324917,
-0.013642632402479649,
-0.054865770041942596,
0.013679537922143936,
0.03887350484728813,
-0.024357451125979424,
0.006642940919846296,
-0.09344403445720673,
0.017825225368142128,
-0.0156601183116436,
-0.023988397791981697,
-0.05530863255262375,
-0.009189401753246784,
-0.055948324501514435,
-0.012197177857160568,
-0.0018191201379522681,
0.0262273158878088,
0.024382052943110466,
-0.024049906060099602,
0.000552040699403733,
0.04239180311560631,
0.017603794112801552,
0.024111416190862656,
-0.028318611904978752,
0.034961551427841187,
-0.034272655844688416,
0.018009750172495842,
-0.06160712614655495,
-0.0047084917314350605,
0.03825841844081879,
-0.020125649869441986,
0.036462366580963135,
-0.018993889912962914,
-0.00026737069129012525,
-0.03333772346377373,
0.050338730216026306,
0.01852642372250557,
-0.041506078094244,
-0.0139378746971488,
-0.01270770002156496,
-0.03936557471752167,
-0.03530599921941757,
-0.024049906060099602,
-0.007873115129768848,
-0.029573388397693634,
0.03675760701298714,
0.030778959393501282,
-0.019030796363949776,
-0.02456657961010933,
0.026670178398489952,
-0.004041122272610664,
-0.01853872649371624,
0.015955360606312752,
-0.02428364008665085,
-0.02539079636335373,
-0.030828166753053665,
-0.002028249902650714,
0.05683404952287674,
0.02662097103893757,
0.002623346634209156,
0.0016284431330859661,
-0.02388998307287693,
0.047829173505306244,
-0.00886340532451868,
0.0014931239420548081,
0.020630022510886192,
0.013654934242367744,
-0.012055708095431328,
0.019116908311843872,
0.012492419220507145,
0.0006631407886743546,
0.03980843722820282,
-0.0428592711687088,
-0.034961551427841187,
-0.00580334709957242,
0.02922894060611725,
-0.019264528527855873,
0.02320108562707901,
-0.0349123440682888,
0.016336714848876,
0.03513377532362938,
-0.005345107056200504,
-0.020937565714120865,
0.0005485808360390365,
-0.016152188181877136,
0.0014877419453114271,
-0.047853779047727585,
0.003321470459923148,
0.00046208419371396303,
-0.021614162251353264,
-0.0140116848051548,
0.001034884131513536,
-0.050314128398895264,
-0.003095425898209214,
-0.011766617186367512,
0.07568032294511795,
0.016582749783992767,
-0.022733619436621666,
-0.040177490562200546,
0.021208204329013824,
0.000525130657479167,
0.001593075692653656,
-0.037840161472558975,
-0.02937656082212925,
0.013125958852469921,
0.020371684804558754,
-0.011040814220905304,
-0.0051544299349188805,
-0.018194276839494705,
0.012283289805054665,
-0.03225516900420189,
0.056095946580171585,
0.013864063657820225,
-0.00707350205630064,
0.013962477445602417,
0.010880891233682632,
0.04369578883051872,
-0.03904573246836662,
0.020224064588546753,
-0.01563551463186741,
0.026301125064492226,
-0.0340266190469265,
-0.03582267463207245,
-0.03449408710002899,
0.020507004112005234,
0.010776326060295105,
-0.000026837980840355158,
-0.03227977082133293,
-0.005609594751149416,
0.005369710735976696,
-0.020076444372534752,
0.005025262013077736,
-0.026178108528256416,
-0.005215938668698072,
-0.0036905228625983,
-0.014958919025957584,
-0.033313117921352386,
-0.0067413547076284885,
0.032624222338199615,
-0.03916874900460243,
0.02291814610362053,
-0.007614778820425272,
-0.0007980755181051791,
-0.009540000930428505,
0.04005447402596474,
0.03705284744501114,
0.031640082597732544,
-0.006098588928580284,
0.03159087523818016,
0.029327353462576866,
-0.002092833863571286,
0.003358375746756792,
0.023668551817536354,
0.005791045259684324,
0.003788936650380492,
0.009902902878820896,
-0.022610602900385857,
-0.013175166212022305,
-0.03338693082332611,
0.001205570762977004,
-0.010548744350671768,
-0.057326119393110275,
0.012596984393894672,
-0.032968670129776,
-0.031517066061496735,
0.01160669419914484,
-0.002531083533540368,
0.03968542069196701,
-0.03818460926413536,
0.03884890303015709,
-0.010517990216612816,
0.03375598043203354,
-0.024541975930333138,
-0.009589208289980888,
-0.03021308034658432,
-0.010296558029949665,
-0.05481656640768051,
-0.002271209144964814,
0.0009026403422467411,
-0.013224373571574688,
0.025759849697351456,
-0.008764991536736488,
0.020691530779004097,
-0.002681779908016324,
0.03282104805111885,
-0.028097180649638176,
0.025612227618694305,
0.03282104805111885,
0.047706156969070435,
-0.001860638614743948,
-0.010382670909166336,
0.04185052961111069,
-0.015758533030748367,
0.020789945498108864,
-0.021589558571577072,
-0.005797196179628372,
-0.029770217835903168,
-0.0025741395074874163,
0.02772812731564045,
-0.036191727966070175,
-0.00573568744584918,
-0.03471551835536957,
0.06519923359155655,
0.03154166787862778,
0.0557514987885952,
-0.037028245627880096,
0.0469188466668129,
-0.02222924865782261,
-0.05028952285647392,
-0.02376696653664112,
-0.003290716093033552,
0.01374104619026184,
0.013765649870038033,
-0.020420892164111137,
0.014885108917951584,
0.0077439467422664165,
0.05343876779079437,
-0.004065725952386856,
0.05727691203355789,
0.06578972190618515,
-0.006612186785787344,
-0.015032729133963585,
-0.009164798073470592,
0.00027851914637722075,
-0.013777951709926128,
0.05028952285647392,
0.000026117175366380252,
-0.03968542069196701,
0.003705899929627776,
0.0584578812122345,
-0.01674267090857029,
0.06480558216571808,
-0.031074201688170433,
-0.04996967688202858,
0.03651157021522522,
0.03336232528090477,
0.015303367748856544,
0.021478842943906784,
0.009416983462870121,
-0.011120774783194065,
-0.06057377904653549,
-0.04411404952406883,
-0.04876410588622093,
0.01649663597345352,
-0.007916171103715897,
0.03414963558316231,
0.00171763077378273,
-0.002586441347375512,
-0.057621363550424576,
-0.03139404579997063,
-0.023840777575969696,
0.03181230649352074,
0.007128859870135784,
0.041653700172901154,
-0.03510917350649834,
-0.02706383354961872,
0.05353718250989914,
-0.00336452666670084,
0.07518824934959412,
0.006519923452287912,
-0.030040854588150978,
-0.009576906450092793,
-0.04244101047515869,
0.00254184752702713,
0.022549094632267952,
0.05767056718468666,
0.003542901948094368,
0.026399539783596992,
-0.02140503190457821,
0.001982118235900998,
0.0752374604344368,
0.001045648125000298,
-0.003358375746756792,
-0.01578313484787941,
0.004404023755341768,
-0.025046348571777344,
0.029819423332810402,
-0.08768682181835175,
0.05890074372291565,
-0.017062516883015633,
-0.014675978571176529,
0.024000700563192368,
-0.029327353462576866,
0.007491761352866888,
-0.03870128095149994,
0.016828782856464386,
0.05584990978240967,
-0.03264882415533066,
-0.03395280987024307,
-0.014958919025957584,
-0.018710950389504433,
0.037667933851480484,
0.0262273158878088,
-0.016127584502100945,
-0.03818460926413536,
0.03033609688282013,
-0.04613153263926506,
-0.031246425583958626,
-0.019805805757641792,
0.0584578812122345,
0.009214005433022976,
-0.001440841588191688,
-0.0174561720341444,
-0.02047009952366352,
0.019153812900185585,
0.029721010476350784,
0.0036351648159325123,
-0.021454239264130592,
-0.039217956364154816,
-0.005375861655920744,
-0.004905319772660732,
-0.03063133917748928,
-0.022622903808951378,
-0.004114932846277952,
0.04160449281334877,
-0.010351916775107384,
0.003921180497854948,
-0.017333155497908592,
0.0055665383115410805,
0.015229557640850544,
0.010148937813937664,
-0.038652073591947556,
0.006519923452287912,
0.07838670164346695,
0.04576248303055763,
-0.032599616795778275,
-0.012806113809347153,
-0.02529238350689411,
0.039463989436626434,
-0.031910721212625504,
0.0053328052163124084,
-0.00021528049546759576,
-0.012892225757241249,
-0.022684413939714432,
0.02799876593053341,
-0.011071568354964256,
-0.002743288641795516,
-0.03474012017250061,
0.043031495064496994,
0.006049382034689188,
0.029844027012586594,
0.04913315922021866,
-0.002893985016271472,
0.022167740389704704,
0.04219497740268707,
-0.022204644978046417,
0.040029868483543396,
-0.026547159999608994,
-0.011686655692756176,
-0.003093888284638524,
-0.0237546656280756,
0.009170949459075928,
-0.006476867478340864,
-0.029696406796574593,
-0.032058339565992355,
-0.014651374891400337,
-0.002175870817154646,
-0.0077500976622104645,
0.03724967688322067,
-0.02209392935037613,
-0.02318878471851349,
0.01051183883100748,
0.017677603289484978,
0.010899343527853489,
-0.04657439887523651,
-0.046180739998817444,
-0.05447211489081383,
-0.041530683636665344,
-0.06382144242525101,
0.011532883159816265,
-0.019596675410866737,
0.015094238333404064,
0.011649750173091888,
-0.05161811038851738,
0.011440620757639408,
-0.03186151385307312,
0.016041472554206848,
-0.012609286233782768,
-0.01591845415532589,
0.008076094090938568,
-0.001210952759720385,
-0.004696190357208252,
0.00755327008664608,
0.02858925051987171,
0.0086542759090662,
0.04103861376643181,
-0.02002723701298237,
-0.0106410076841712,
-0.007067351136356592,
0.03304247930645943,
0.00927551370114088,
0.009945958852767944,
0.009312419220805168,
0.012129518203437328,
0.004059575032442808,
-0.00010091272997669876,
-0.03405122458934784,
0.001616141409613192,
0.005606519058346748,
-0.000412877241615206,
0.008432844653725624,
-0.007085803896188736,
-0.04901014268398285,
-0.016373619437217712,
0.00374280521646142,
0.009515398181974888,
-0.019252227619290352,
-0.03365756571292877,
0.028663059696555138,
-0.05132286995649338,
0.002389613538980484,
-0.026965418830513954,
-0.05393083766102791,
0.05461973696947098,
-0.002132814610376954,
-0.04214577004313469,
0.022180041298270226,
-0.013236675411462784,
-0.015574006363749504,
-0.021491143852472305,
-0.031517066061496735,
0.004545493982732296,
0.03887350484728813,
-0.000004063539563503582,
0.038233816623687744,
-0.02318878471851349,
0.0040903291665017605,
0.005821799859404564,
0.001217872486449778,
0.0034291106276214123,
0.002897060476243496,
0.03843064233660698,
-0.011692806147038937,
-0.03990685194730759,
0.003189226845279336,
0.01691489666700363,
-0.01952286623418331,
-0.04568867012858391,
0.025882866233587265,
0.013716442510485649,
-0.022696714848279953,
-0.003293791553005576,
-0.025587623938918114,
-0.027088437229394913,
0.030286889523267746,
0.004105706699192524,
-0.02664557471871376,
-0.001602301956154406,
-0.000728109385818243,
0.04020209610462189,
0.036880623549222946,
-0.020248668268322945,
-0.012172574177384377,
0.004247176460921764,
0.025243176147341728,
-0.049502212554216385,
-0.02074073813855648,
0.03186151385307312,
0.003650542115792632,
-0.004317911807447672,
-0.00009058119030669332,
-0.019326036795973778,
0.007368743885308504,
-0.033977411687374115,
-0.03518298268318176,
0.00218202150426805,
-0.013556520454585552,
0.015204953961074352,
0.023976096883416176,
-0.001859100884757936,
-0.02922894060611725,
-0.023680854588747025,
0.005935590714216232,
0.000017563621440785937,
-0.04463072121143341,
0.011446771211922169,
-0.005588066764175892,
-0.03200913220643997,
-0.021515747532248497,
-0.015574006363749504,
0.02471419982612133,
0.00003171542994095944,
-0.04295768588781357,
0.01456526294350624,
-0.00549272820353508,
-0.0073810457251966,
-0.013482709415256977,
-0.000584332796279341,
-0.039759233593940735,
-0.017136327922344208,
-0.011858879588544369,
0.011077718809247017,
0.02718685008585453,
0.019941125065088272,
-0.029597992077469826,
-0.03599489852786064,
0.001649971236474812,
-0.001445454778149724,
0.05929439887404442,
-0.000528974924236536,
0.00017924023268278688,
0.009041780605912209,
-0.026128901168704033,
0.001919071888551116,
0.014233116060495377,
-0.017271647229790688,
0.0065937340259552,
0.02607969380915165,
0.010960852727293968,
0.10904264450073242,
0.013039846904575825,
0.048395056277513504,
-0.027506696060299873,
0.005342031829059124,
-0.004760774318128824,
-0.022868938744068146,
0.012590833008289337,
-0.01743156835436821,
-0.013974779285490513,
-0.003561354475095868,
0.00614779582247138,
-0.014479150995612144,
-0.05968805402517319,
0.003939633257687092,
0.01228944119066,
-0.008180658333003521,
0.006049382034689188,
-0.0007554038893431425,
-0.0013900968478992581,
0.0051206001080572605,
-0.02940116450190544,
0.010216597467660904,
-0.0004593931953422725,
0.020679229870438576,
0.007288782391697168,
0.02252449095249176,
-0.02222924865782261,
-0.019116908311843872,
-0.02994244173169136,
-0.0000014115769317868399,
-0.015155746601521969,
0.03250120207667351,
-0.037274278700351715,
0.019006192684173584,
-0.013236675411462784,
0.012055708095431328,
-0.019879616796970367,
0.01353191677480936,
0.03257501497864723,
-0.013039846904575825,
-0.0051544299349188805,
-0.01567241922020912,
-0.02593207359313965,
-0.0086542759090662,
0.016299808397889137,
-0.001282456680200994,
0.04955141991376877,
0.00023680854064878076,
0.022696714848279953,
-0.015131142921745777,
-0.005403540562838316,
0.0115390345454216,
0.000503602612297982,
0.041506078094244,
0.023828474804759026,
-0.03953779861330986,
0.016361316666007042,
-0.02868766337633133,
-0.01510654017329216,
-0.01894468441605568,
0.012338647618889809,
-0.01810816489160061,
-0.03712666034698486,
-0.024874122813344002,
0.026571763679385185,
-0.04155528545379639,
-0.029425768181681633,
-0.0373234860599041,
-0.004108781926333904,
0.03862747177481651,
-0.01160669419914484,
-0.03141865134239197,
-0.009736829437315464,
-0.010228899307549,
0.03980843722820282,
0.03749570995569229,
-0.006409207824617624,
0.0025741395074874163,
-0.010308859869837761,
0.0058341012336313725,
0.009189401753246784,
-0.048247434198856354,
0.005572689231485128,
0.008137602359056473,
0.000711194472387433,
-0.011649750173091888,
-0.007614778820425272,
-0.015500195324420929,
-0.03990685194730759,
-0.001328588230535388,
-0.014257719740271568,
-0.006882824935019016,
0.005019111093133688,
0.0056280470453202724,
-0.010542592965066433,
-0.004579323809593916,
0.010610252618789673,
-0.022143136709928513,
0.014479150995612144,
0.0005355102475732565,
-0.015820041298866272,
0.009226307272911072,
-0.015487893484532833,
0.015561704523861408,
-0.008605068549513817,
-0.07996132969856262,
0.004508588463068008,
0.010265803895890713,
0.012012651190161705,
-0.029302749782800674,
0.0061785499565303326,
0.002580290427431464,
0.016299808397889137,
-0.00446245726197958,
0.0027386753354221582,
0.007227273657917976,
0.040989406406879425,
-0.04049733653664589,
-0.009896751493215561,
-0.029351957142353058,
0.030139269307255745,
-0.027531299740076065,
0.028613852337002754,
0.003998066298663616,
-0.006538376212120056,
0.03843064233660698,
-0.10353146493434906,
-0.01839110441505909,
-0.04189973324537277,
-0.013925572857260704,
-0.027088437229394913,
-0.010757873766124249,
-0.020420892164111137,
-0.013642632402479649,
0.00412415899336338,
-0.006772109307348728,
0.019449055194854736,
-0.030311493203043938,
-0.005692631471902132,
-0.009398531168699265,
0.028736870735883713,
-0.01099160686135292,
-0.011040814220905304,
-0.05821184441447258,
-0.012781510129570961,
0.01222793199121952,
0.008199111558496952,
0.008389788679778576,
0.004287157207727432,
-0.001024888944812119,
-0.006735204253345728,
0.016238300129771233,
-0.009238608181476593,
0.010493386536836624,
-0.01728394813835621,
-0.015955360606312752,
0.01759149134159088,
-0.0073379892855882645,
0.00266178953461349,
0.026867005974054337,
0.000874961435329169,
-0.010075126774609089,
0.0002912053023464978,
-0.008242167532444,
0.004991432186216116,
0.013630330562591553,
0.02031017653644085,
-0.005305126309394836,
0.025193968787789345,
0.01661965437233448,
-0.01504503097385168,
0.012732303701341152,
-0.030655942857265472,
0.012621588073670864,
0.019436752423644066,
-0.023299500346183777,
0.0089925741776824,
-0.018071260303258896,
-0.013495011255145073,
0.001155594945885241,
0.026522556319832802,
0.007411799859255552,
0.029499579221010208,
0.003086199751123786,
0.012307893484830856,
-0.011428318917751312,
-0.0050314124673604965,
0.042785461992025375,
0.010825533419847488,
-0.013581124134361744,
-0.021109789609909058,
0.00480998121201992,
-0.009921355172991753,
0.028786078095436096,
-0.006735204253345728,
0.035502828657627106,
-0.03181230649352074,
0.02772812731564045,
-0.01579543761909008,
0.03870128095149994,
-0.03183690831065178,
-0.009669169783592224,
-0.018969286233186722,
0.017517682164907455,
-0.003155397018417716,
0.03282104805111885,
0.008076094090938568,
-0.000905715802218765,
-0.056489601731300354,
-0.004686963744461536,
-0.039316367357969284,
0.005483501590788364,
0.01454065926373005,
0.003924255724996328,
0.010899343527853489,
0.0036659191828221083,
-0.012178725562989712,
-0.021454239264130592,
-0.029007509350776672,
0.007885416969656944,
0.0073933470994234085,
-0.02566143497824669,
0.003140019718557596,
-0.006587583106011152,
-0.008777293376624584,
-0.004517815075814724,
0.043302133679389954,
-0.03021308034658432,
0.01990421861410141,
-0.005501954350620508,
-0.002118975156918168,
-0.003052369924262166,
0.02593207359313965,
-0.01590615324676037,
-0.0296718031167984,
-0.031369443982839584,
0.001420082408003509,
-0.004096480086445808,
0.038086194545030594,
-0.00731338607147336,
0.0118773328140378,
0.0263749361038208,
-0.001375488587655127,
-0.020285572856664658,
0.012369401752948761,
-0.031123409047722816,
0.05270066484808922,
0.00473617110401392,
0.022905845195055008,
0.02512015774846077,
-0.023090369999408722,
0.005052940919995308,
-0.023028861731290817,
0.011434469372034073,
-0.007768550422042608,
0.003103114664554596,
0.013900969177484512,
0.027088437229394913,
0.0017899035010486841,
0.007891567423939705,
0.019399847835302353,
0.000846513663418591,
0.01920302025973797,
-0.001407780684530735,
0.017542283982038498,
0.010831683874130249,
-0.014786694198846817,
-0.005741838365793228,
0.017197836190462112,
0.01449145283550024,
0.004277931060642004,
0.001407780684530735,
-0.030016250908374786,
0.007879266515374184,
0.02718685008585453,
0.0005808729329146445,
0.0009026403422467411,
0.01837880350649357,
-0.005292824935168028,
-0.006716751493513584,
0.04187513142824173,
0.05584990978240967,
0.014614470303058624,
-0.011828125454485416,
-0.041235439479351044,
0.015020427294075489,
-0.03227977082133293,
0.044950567185878754,
-0.022327663376927376,
-0.02858925051987171,
0.005966345313936472,
-0.023139577358961105,
-0.014048590324819088,
0.0032230564393103123,
-0.015020427294075489,
0.022352267056703568,
0.014885108917951584,
-0.020125649869441986,
0.01991652138531208,
-0.01064715813845396,
0.016656558960676193,
0.004853037651628256,
0.013556520454585552,
0.03218135982751846,
0.006599884945899248,
-0.015598609112203121,
-0.003687447402626276,
-0.01133605558425188,
0.007700890768319368,
0.003336847759783268,
0.03695443272590637,
-0.004477834329009056,
-0.021860197186470032,
-0.012756907381117344,
0.055407047271728516,
0.01263388991355896,
-0.02456657961010933,
0.0000030033550046937307,
-0.009183250367641449,
0.07297393679618835,
0.04418785870075226,
-0.013544218614697456,
-0.016841085627675056,
0.017210137099027634,
-0.040029868483543396,
-0.017493078485131264,
-0.01009358000010252,
0.02416062168776989,
0.013175166212022305,
-0.015697022899985313,
-0.040964800864458084,
0.00590791180729866,
0.01216027233749628,
-0.05314352735877037,
0.0014054740313440561,
0.04802600294351578,
0.00038116180803626776,
0.015426385216414928,
-0.019141511991620064,
0.024935632944107056,
-0.01201880257576704,
0.013851761817932129,
0.01771450974047184,
0.03545362129807472,
-0.03227977082133293,
-0.026694782078266144,
-0.007264179177582264,
-0.05068317800760269,
-0.006636789999902248,
-0.014036288484930992,
0.000397115625673905,
0.005994024220854044,
0.01837880350649357,
0.00755327008664608,
-0.014589866623282433,
0.04217037186026573,
0.008562012575566769,
0.030778959393501282,
0.014270021580159664,
0.01085013709962368,
0.012080310843884945,
0.011286849156022072,
-0.01518035028129816,
-0.014417641796171665,
0.000868810573592782,
-0.015684721991419792,
0.04472913593053818,
0.008623521775007248,
-0.007135010790079832,
-0.04189973324537277,
-0.012283289805054665,
-0.002684855367988348,
0.019670486450195312,
-0.03395280987024307,
-0.03665919229388237,
-0.03250120207667351,
-0.008598918095231056,
0.02184789441525936,
0.016312111169099808,
0.018637139350175858,
0.03171389177441597,
0.01949826255440712,
0.0019206095021218061,
0.008838801644742489,
-0.002844777889549732,
-0.006845919881016016,
-0.00009620346827432513,
-0.02500944212079048,
-0.015118842013180256,
-0.0073994980193674564,
0.02224154956638813,
0.006132418755441904,
0.0045362673699855804,
0.006888975854963064,
-0.0003044681216124445,
0.04128464683890343,
0.03533060476183891,
-0.00182834651786834,
-0.012172574177384377,
-0.030311493203043938,
-0.026547159999608994,
-0.029868630692362785,
0.013630330562591553,
0.019695090129971504,
0.03392820432782173,
-0.016644258052110672,
-0.007011993322521448,
-0.01147137489169836,
0.008666577748954296,
0.01841570809483528,
0.03734809160232544,
-0.028318611904978752,
-0.03633934631943703,
-0.025636831298470497,
-0.001083322218619287,
0.003441412467509508,
-0.025193968787789345,
0.008395939134061337,
-0.0006546833319589496,
-0.0018621762283146381,
0.0029170506168156862,
-0.017382362857460976,
0.03230437636375427,
-0.014233116060495377,
-0.02336100861430168,
-0.03683141618967056,
0.0019359866855666041,
0.02348402701318264,
-0.01497122086584568,
-0.0107148177921772,
0.015881549566984177,
-0.024000700563192368,
0.003100039204582572,
-0.038504455238580704,
0.009989014826714993,
0.007325687445700169,
-0.03380518779158592,
0.02583365887403488,
0.011440620757639408,
0.016865689307451248,
0.025440003722906113,
0.03213215246796608,
-0.015192652121186256,
0.012609286233782768,
-0.015487893484532833,
0.004170290660113096,
0.00235117063857615,
0.050043489784002304,
-0.016127584502100945,
-0.008149904198944569,
0.00927551370114088,
-0.018464915454387665,
0.011668202467262745,
0.014774392358958721,
0.008365185000002384,
-0.03380518779158592,
-0.002807872835546732,
0.0005112911458127201,
-0.003970387391746044,
-0.006882824935019016,
-0.036314744502305984,
0.008549710735678673,
-0.0074487049132585526,
0.039070334285497665,
0.008014584891498089,
-0.0028663061093539,
0.017616095021367073,
0.0158077385276556,
0.004302534274756908,
0.022573698312044144,
0.017001008614897728,
-0.007356442045420408,
0.03257501497864723,
-0.0085804658010602,
0.009146345779299736,
-0.04199814796447754,
0.056932464241981506,
-0.00831597764045,
-0.05658801645040512,
0.05166731774806976,
0.009896751493215561,
0.01894468441605568,
0.012492419220507145,
-0.029819423332810402,
-0.031221821904182434,
0.002278897911310196,
0.001304753590375185,
0.013581124134361744,
0.0020759189501404762,
-0.007996132597327232,
0.017899034544825554,
0.008014584891498089,
0.010696365498006344,
-0.010468782857060432,
0.004548569209873676,
-0.011034662835299969,
0.0009679933427833021,
0.02446816675364971,
-0.007707041688263416,
-0.01812046766281128,
-0.0055388594046235085,
0.008758841082453728,
0.020826850086450577,
-0.002271209144964814,
-0.000998747767880559,
0.0313202366232872,
-0.014479150995612144,
-0.02129431627690792,
0.026719383895397186,
-0.002469574799761176,
0.044975169003009796,
-0.021638765931129456,
-0.06406747549772263,
-0.00583717692643404,
0.026867005974054337,
-0.006655242759734392,
-0.007663985714316368,
0.005086770746856928,
0.015574006363749504,
0.002595667727291584,
-0.007774701341986656,
-0.043031495064496994,
0.016693465411663055,
0.0013024469371885061,
0.01091779675334692,
0.010044372640550137,
-0.012012651190161705,
0.008820349350571632,
0.013347391039133072,
0.004972979426383972,
0.0040349713526666164,
0.0069689373485744,
-0.00456702196970582,
0.0214296355843544,
0.03904573246836662,
0.020494703203439713,
-0.026276521384716034,
0.00016645794676151127,
-0.044532306492328644,
0.006153946742415428,
-0.007891567423939705,
0.006117041688412428,
-0.0024572729598730803,
-0.018231183290481567,
-0.034666310995817184,
0.009330871514976025,
0.01609067991375923,
0.008697331883013248,
0.025243176147341728,
-0.008205262012779713,
-0.009349324740469456,
-0.019670486450195312,
-0.01577083393931389,
0.020150253549218178,
-0.012769208289682865,
0.02706383354961872,
0.0055634630843997,
0.003235358279198408,
0.02154035121202469,
-0.019535167142748833,
-0.011286849156022072,
-0.01564781740307808,
0.012055708095431328,
-0.004622379783540964,
-0.021085185930132866,
0.007922322489321232,
-0.0018022052245214581,
0.03294406831264496,
0.003730503376573324,
0.01797284558415413,
0.004007292445749044,
-0.016644258052110672,
0.017099421471357346,
-0.0232256893068552,
0.032870255410671234,
0.019867314025759697,
-0.010954701341688633,
0.01989191770553589,
-0.016164489090442657,
-0.022216947749257088,
0.02281973324716091,
-0.004056499805301428,
-0.008912612684071064,
0.01064715813845396,
0.007663985714316368,
-0.014393039047718048,
-0.035625845193862915,
0.032747238874435425,
-0.018329596146941185,
0.030409907922148705,
-0.00491147069260478,
-0.0034045071806758642,
-0.009263211861252785,
0.008438995108008385,
-0.0076885889284312725,
0.0002760203497018665,
0.006962786428630352,
-0.00466851145029068,
-0.00446553248912096,
0.018760157749056816,
0.041407667100429535,
-0.023151880130171776,
0.002466499339789152,
0.006753656547516584,
0.02224154956638813,
0.01784982904791832,
-0.045934706926345825,
0.013618028722703457,
0.005781819112598896,
-0.000293319666525349,
0.02154035121202469,
0.024271337315440178,
0.028244800865650177,
-0.03717586770653725,
0.030237684026360512,
0.01353191677480936,
-0.014466849155724049,
-0.009047931991517544,
0.0075102136470377445,
0.001883704331703484,
-0.005040639080107212,
0.0069812387228012085,
-0.00008481474651489407,
-0.00030254598823376,
0.000581257336307317,
0.03036070056259632,
-0.023557836189866066,
-0.020297875627875328,
-0.000602016516495496,
-0.02074073813855648,
0.025513814762234688,
0.011852729134261608,
-0.022266153246164322,
-0.008678879588842392,
0.001188655849546194,
-0.009214005433022976,
-0.03680681437253952,
0.00386274722404778,
0.0054219928570091724,
0.005206712521612644,
0.03609331324696541,
-0.026670178398489952,
0.015229557640850544,
0.03835683315992355,
0.014134702272713184,
0.006070910021662712,
0.019043097272515297,
0.002118975156918168,
0.005517331417649984,
-0.04844426363706589,
-0.04069416597485542,
-0.007344140205532312,
-0.007651683874428272,
0.02019946090877056,
-0.034641705453395844,
0.02760511077940464,
0.012830717489123344,
-0.02500944212079048,
0.05063397064805031,
-0.005797196179628372,
-0.01852642372250557,
0.030582131817936897,
0.0046531339175999165,
0.0085804658010602,
-0.004102631006389856,
-0.036019500344991684,
-0.015131142921745777,
0.016705766320228577,
0.03675760701298714,
0.021589558571577072,
0.02115899696946144,
0.01743156835436821,
0.03690522909164429,
-0.024529675021767616,
-0.004351741634309292,
0.02703922986984253,
0.01621369644999504,
-0.000966455671004951,
-0.0049822055734694,
0.014614470303058624,
-0.015278764069080353,
-0.007676287554204464,
0.02541540004312992,
-0.014073193073272705,
-0.0475093312561512,
-0.04241640865802765,
0.016029169782996178,
0.002723298268392682,
-0.023570138961076736,
0.02032247930765152,
0.000368667853763327,
0.01840340718626976,
-0.02171257510781288,
-0.016804181039333344,
-0.019990332424640656,
0.013814857229590416,
0.003994991071522236,
-0.018452614545822144,
-0.015832342207431793,
-0.009300117380917072,
-0.03574886545538902,
0.006289266049861908,
0.025218572467565536,
0.0075717223808169365,
-0.013408899307250977,
-0.022979654371738434,
-0.03680681437253952,
-0.03075435571372509,
-0.017333155497908592,
0.0012816877570003271,
-0.019424451515078545,
-0.04394182562828064,
-0.027629714459180832,
0.012966036796569824,
-0.001155594945885241,
-0.015303367748856544,
-0.02841702476143837,
0.004416325595229864,
-0.018145069479942322,
-0.05058476701378822,
0.008943366818130016,
0.012480117380619049,
-0.011102322489023209,
0.022007817402482033,
-0.024935632944107056,
-0.004425551742315292,
-0.02703922986984253,
0.03582267463207245,
-0.012720001861453056,
-0.018514122813940048,
-0.0011033124756067991,
0.018870873376727104,
-0.009287815541028976,
-0.034395672380924225,
-0.005994024220854044,
0.012258686125278473,
-0.047558534890413284,
0.028072576969861984,
0.03195992857217789,
0.00501296017318964,
0.022832034155726433,
0.010930098593235016,
-0.057326119393110275,
0.001513883238658309,
0.011231491342186928,
0.010973154567182064,
0.0343218632042408,
0.04108782112598419,
-0.011243792250752449,
-0.03434646502137184,
0.000859584251884371,
0.04192433878779411,
0.012541626580059528,
0.000830367614980787,
0.04531962051987648,
0.00460392702370882,
0.00528667401522398,
-0.009386229328811169,
-0.01222793199121952,
-0.019572071731090546,
0.000397500058170408,
-0.006710600573569536,
-0.021774083375930786,
-0.006993540562689304,
-0.013765649870038033,
0.002537234453484416,
0.013777951709926128,
0.02500944212079048,
0.003247660119086504,
-0.008740387856960297,
-0.02541540004312992,
0.040595751255750656,
-0.008537408895790577,
-0.02799876593053341,
0.009429285302758217,
-0.024136018007993698,
-0.05043714493513107,
0.01826808787882328,
0.015697022899985313,
0.012307893484830856,
0.010862438939511776,
0.023582439869642258,
0.0007123477989807725,
-0.01462677214294672,
-0.026055090129375458,
-0.021601859480142593,
-0.003358375746756792,
0.00031888423836790025,
0.010800929740071297,
0.03417424112558365,
-0.013568822294473648,
-0.008266771212220192,
0.018071260303258896,
0.029056716710329056,
-0.015709325671195984,
0.018206579610705376,
-0.0047700004652142525,
0.004766925238072872,
0.00212820153683424,
0.020113348960876465,
0.10235049575567245,
-0.019707391038537025,
-0.003890426130965352,
0.00376125774346292,
-0.011754315346479416,
-0.002414216985926032,
0.022487584501504898,
0.009373927488923073,
0.03857826441526413,
-0.01866174302995205,
0.031221821904182434,
0.007055049296468496,
0.04064495861530304,
0.028933698311448097,
0.017111724242568016,
-0.01380255538970232,
-0.014245417900383472,
-0.007614778820425272,
0.010462632402777672,
-0.021183600649237633,
0.0166319552809,
0.011151529848575592,
-0.026276521384716034,
0.028244800865650177,
-0.009490794502198696,
0.002572601893916726,
0.006243134383112192,
-0.0036935980897396803,
0.001580773969180882,
-0.003007776103913784,
0.027555903419852257,
0.00326303718611598,
0.01852642372250557,
-0.02019946090877056,
-0.00590483658015728,
-0.0181327685713768,
-0.006962786428630352,
-0.015414083376526833,
-0.018341898918151855,
0.02718685008585453,
-0.00491147069260478,
0.021761782467365265,
-0.0054219928570091724,
0.02047009952366352,
0.012892225757241249,
0.026399539783596992,
-0.029474975541234016,
-0.017677603289484978,
-0.001522340695373714,
-0.03560124337673187,
0.010382670909166336,
-0.0038166155572980642,
0.017357759177684784,
0.015746230259537697,
0.006243134383112192,
-0.011182283982634544,
0.027137644588947296,
-0.03319010138511658,
-0.014823599718511105,
-0.014725185930728912,
-0.01759149134159088,
0.041678301990032196,
0.0023127275053411722,
0.01909230463206768,
0.010530292056500912
] | 2025-01-08 | 30 | 39775044 | [
"CAR T cell distribution",
"pediatric CNS tumors",
"repeated doses",
"ICV B7-H3 CAR T cells",
"B7-H3 CAR T cells",
"Diffuse intrinsic pontine glioma",
"DIPG",
"ICV",
"intra-patient dose-escalation regimens",
"protocol therapy",
"Arm C",
"Secondary objectives",
"B7-H3-targeting chimeric antigen receptor T cells",
"recurrent or refractory CNS tumors",
"CNS",
"Concurrent tumor-directed therapy",
"253 ICV doses",
"patients",
"previous lymphodepletion",
"the highest planned dose regimen",
"feasibility",
"survival",
"a fatal central nervous system",
"-",
"irradiation",
"re",
"B7-H3",
"DR4",
"assessments",
"CNS) tumor"
] | [] | 0 | 10.1038/s41591-024-03451-3
10.1093/neuonc/nox107
10.1007/s11940-019-0577-y
10.1182/blood-2017-02-769208
10.1056/NEJMoa1407222
10.1016/j.neo.2022.100870
10.1158/2159-8290.CD-22-0750
10.1200/JCO.23.02019
10.1038/s41591-021-01404-8
10.18632/oncotarget.27389
10.1093/neuonc/noaa278
10.1158/1078-0432.CCR-18-0432
10.1007/s11060-012-1021-2
10.1016/j.tranon.2019.11.006
10.1016/j.ccell.2019.01.002
10.1016/j.ebiom.2019.08.030
10.3389/fimmu.2021.691741
10.1016/j.omto.2020.03.019
10.1002/cti2.1137
10.1038/s41392-021-00505-7
10.1002/cncr.21749
10.1038/s41591-023-02276-w
10.1007/s00381-017-3352-y
10.1093/neuonc/noy070
10.1155/2017/5813951
10.1016/j.ccell.2017.08.017
10.1158/2326-6066.CIR-21-0501
10.1038/gt.2012.97 | [
"Vitanza",
"Ronsley",
"Choe",
"Seidel",
"Huang",
"Rawlings-Rhea",
"Beam",
"Steinmetzer",
"Wilson",
"Brown",
"Beebe",
"Lindgren",
"Gustafson",
"Wein",
"Holtzclaw",
"Hoeppner",
"Goldstein",
"Browd",
"Hauptman",
"Lee",
"Ojemann",
"Crotty",
"Leary",
"Perez",
"Wright",
"Alonso",
"Dun",
"Foster",
"Hurst",
"Kong",
"Thomsen",
"Orentas",
"Albert",
"Pinto",
"Annesley",
"Gardner",
"Ho",
"Pattabhi",
"Gust",
"Wendler",
"Park",
"Jensen"
] | [
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA. [email protected].\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA. [email protected].\nSeattle Children's Therapeutics, Seattle, WA, USA. [email protected].",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.\nSeattle Children's Therapeutics, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Division of Neurosurgery, Seattle Children's Hospital and Department of Neurological Surgery, University of Washington, Seattle, WA, USA.",
"Division of Neurosurgery, Seattle Children's Hospital and Department of Neurological Surgery, University of Washington, Seattle, WA, USA.",
"Division of Neurosurgery, Seattle Children's Hospital and Department of Neurological Surgery, University of Washington, Seattle, WA, USA.",
"Division of Neurosurgery, Seattle Children's Hospital and Department of Neurological Surgery, University of Washington, Seattle, WA, USA.",
"Division of Neurosurgery, Seattle Children's Hospital and Department of Neurological Surgery, University of Washington, Seattle, WA, USA.\nCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA.",
"Department of Radiology, Seattle Children's Hospital, Seattle, WA, USA.",
"Department of Pediatrics, Program of Solid Tumors, University Clinic of Navarra, CIMA-Universidad de Navarra, Pamplona, Spain.",
"Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.\nPrecision Medicine Research Program, Hunter Medical Research Institute, Newcastle, New South Wales, Australia.\nPaediatric Stream, Mark Hughes Foundation Centre for Brain Cancer Research, College of Health, Medicine and Wellbeing, Newcastle, New South Wales, Australia.",
"Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.\nDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.",
"Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Department of Pharmacy, Seattle Children's Hospital, Seattle, WA, USA.",
"Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.\nSeattle Children's Therapeutics, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.\nSeattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDivision of Pediatric Neurology, Department of Neurology, University of Washington, Seattle, WA, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA.",
"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, Seattle, WA, USA.\nDepartment of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.\nSeattle Children's Therapeutics, Seattle, WA, USA.\nDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.",
"Seattle Children's Therapeutics, Seattle, WA, USA."
] | [
"39775044",
"28821206",
"31290035",
"28408462",
"25317870",
"36599192",
"36259971",
"39238483",
"38771986",
"34253928",
"31903167",
"33320196",
"30655315",
"23232807",
"31887631",
"30753824",
"31466914",
"34211478",
"32346608",
"33767145",
"16463390",
"37024595",
"28251325",
"29741745",
"32357322",
"28512646",
"33977272",
"28966033",
"35580141",
"23303282"
] | [] | 10.046144 | 6.926618 |
39774788 | 61 | Pre-treatment Pulmonary Function Testing Has Limited Utility In B-cell Lymphoma Treated with CD19 CAR T-cells. | Pulmonary function tests (PFT) are recommended for hematopoietic cell transplantation (HCT) evaluation. However, their prognostic value in chimeric antigen receptor T-cell (CAR-T) therapy remains unclear. We assessed the predictive significance of PFTs and pulmonary comorbidity classifications, per the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI), in B-cell lymphoma patients undergoing autologous CD19-CAR-T therapy. Single-center retrospective analysis encompassing 192 patients with relapsed/refractory (R/R) B-cell lymphoma, treated with commercial and point-of-care CD19-directed CAR-T therapy. Pre-therapy PFT were conducted, and patients were stratified into 3 HCT-CI-based pulmonary comorbidity grades, utilizing forced expiratory volume in 1 second (FEV1) and single-breath diffusing capacity for carbon monoxide (DLCO). Outcomes and toxicities were evaluated using univariate and multivariable Cox regression, logistic regression, Kaplan-Meier method, and spline models. Pulmonary comorbidity measures were not correlated with overall response rates or immune-toxicities, including cytokine release syndrome grade>2 and immune effector cell-associated neurotoxicity grade>2. Categorical FEV1, DLCO, and pulmonary comorbidity level did not correlate with overall survival (p=0.3, p=0.4, p=0.6, respectively) or progression free survival (PFS) (p=0.058, p>0.9, p=0.2, respectively). FEV1 as continuous measure was associated with reduced PFS in a multivariable model (HR 0.87 [95% CI 0.78-0.96], p=0.007). Spline modeling demonstrated a linear correlation between FEV1 and PFS. Categorical FEV1, DLCO, and pulmonary comorbidity level failed to predict therapy efficacy or toxicity. FEV1 as continuous measure was the sole PFT measure associated with PFS, independent of OS or severe toxicities. | [
0.01015382632613182,
-0.011318916454911232,
0.0547717809677124,
0.04041485860943794,
0.03442654386162758,
-0.012509062886238098,
-0.029716072604060173,
-0.0017679935554042459,
0.023589950054883957,
0.002635547425597906,
-0.04868324473500252,
0.011224958114326,
-0.03304848074913025,
0.007660783361643553,
0.021823523566126823,
-0.029966628178954124,
0.038560736924409866,
-0.03635583445429802,
0.0001847858657129109,
0.03986363485455513,
0.03254736587405205,
0.004773112945258617,
-0.023665117099881172,
-0.03455182537436485,
-0.021673189476132393,
-0.02052062563598156,
0.010936817154288292,
0.03079346753656864,
-0.0084500377997756,
-0.027110278606414795,
0.002972233574837446,
-0.010999456979334354,
-0.00617310032248497,
-0.0271353330463171,
-0.0374833419919014,
0.05351899564266205,
0.013830752111971378,
0.05497222766280174,
-0.027786782011389732,
-0.013354693539440632,
0.004892127122730017,
0.025180988013744354,
-0.01428175438195467,
0.023589950054883957,
-0.04500005394220352,
-0.016774797812104225,
0.039387576282024384,
-0.06574618071317673,
0.020169846713542938,
0.0021391313057392836,
-0.0670991912484169,
0.03903679549694061,
-0.014219115488231182,
-0.01242763176560402,
-0.018140334635972977,
0.047881461679935455,
-0.012941273860633373,
-0.023765340447425842,
-0.002467987360432744,
0.00721604423597455,
0.009890741668641567,
-0.03507799282670021,
0.03267264738678932,
-0.03385026380419731,
-0.06569606810808182,
0.0030661923810839653,
-0.027310723438858986,
-0.03262253478169441,
0.010773954913020134,
0.005637534894049168,
0.0028469550888985395,
0.01756405271589756,
0.021648133173584938,
0.022312110289931297,
0.034902602434158325,
0.026909831911325455,
0.016925131902098656,
-0.00939589086920023,
-0.01664952002465725,
-0.03197108581662178,
-0.020883934572339058,
0.018215501680970192,
0.003965066280215979,
-0.05396999791264534,
0.003586098551750183,
-0.01628621108829975,
-0.0022158643696457148,
-0.020796239376068115,
-0.033223871141672134,
-0.011425403878092766,
-0.0030520986765623093,
-0.024053482338786125,
-0.07075732201337814,
0.043196044862270355,
-0.01807769387960434,
-0.01059230137616396,
0.018390890210866928,
-0.07075732201337814,
-0.014657590538263321,
0.02020742930471897,
0.0172633845359087,
0.06694885343313217,
0.0077923256903886795,
-0.02585749328136444,
0.033023424446582794,
0.04850785434246063,
-0.06108582019805908,
-0.0007172197219915688,
0.023452144116163254,
-0.023965787142515182,
0.08343551307916641,
0.0005155995022505522,
-0.044924888759851456,
0.1070379912853241,
-0.033925432711839676,
-0.014782868325710297,
-0.058931030333042145,
-0.024629762396216393,
-0.020069623365998268,
0.04627789556980133,
-0.01985665038228035,
0.020833821967244148,
0.03447665646672249,
-0.008713123388588428,
-0.006439317483454943,
-0.012164547108113766,
0.041918203234672546,
-0.030993912369012833,
-0.03139480575919151,
-0.09646448493003845,
0.002809371566399932,
-0.011394084431231022,
0.03297331556677818,
-0.02347720041871071,
-0.05973281338810921,
0.0051395525224506855,
-0.0042563388124108315,
0.007829909212887287,
-0.0414421446621418,
-0.0345267690718174,
0.0018995360005646944,
0.0007724205497652292,
0.010016020387411118,
-0.004660361912101507,
-0.04414816200733185,
-0.039537910372018814,
0.006007106509059668,
0.009890741668641567,
-0.020082151517271996,
0.01710052229464054,
-0.03851062431931496,
0.05742768570780754,
0.019004756584763527,
-0.007761006243526936,
0.00972787942737341,
-0.03324892744421959,
0.00281250337138772,
0.022637832909822464,
-0.033925432711839676,
-0.06439317762851715,
-0.005581159144639969,
-0.007097029592841864,
-0.03693211451172829,
-0.01807769387960434,
0.04051508381962776,
-0.025343850255012512,
-0.019768955186009407,
0.04307076334953308,
-0.05667601525783539,
-0.005039329640567303,
-0.00565319461748004,
-0.017626691609621048,
-0.06915375590324402,
-0.050637587904930115,
-0.05071275681257248,
0.02112196385860443,
0.00827464833855629,
0.0061198570765554905,
-0.020833821967244148,
-0.030868634581565857,
-0.0010139732621610165,
0.041617535054683685,
0.04006408154964447,
-0.00005622853495879099,
-0.04302065446972847,
0.021109435707330704,
-0.003161717439070344,
0.055874232202768326,
-0.01939311996102333,
0.009377099573612213,
0.03064313344657421,
-0.01684996485710144,
0.0695546492934227,
0.040389806032180786,
-0.01909245178103447,
-0.003893030807375908,
0.013479972258210182,
0.020094679668545723,
-0.07060699164867401,
-0.008719387464225292,
-0.0011940611293539405,
-0.009602600708603859,
-0.04938480257987976,
-0.03943768888711929,
-0.011870142072439194,
0.0004157681833021343,
-0.028087450191378593,
0.028638675808906555,
0.0037552244029939175,
-0.010147562250494957,
0.030367519706487656,
0.01812780648469925,
-0.031495027244091034,
0.0291147343814373,
-0.015008370392024517,
0.004303317982703447,
-0.01649918407201767,
0.04515038803219795,
0.045952171087265015,
-0.010047339834272861,
0.011356500908732414,
-0.006398601923137903,
0.04374726861715317,
0.04479961097240448,
-0.016712158918380737,
0.004660361912101507,
0.018954643979668617,
-0.026208272203803062,
0.008030354976654053,
-0.06053459644317627,
-0.010147562250494957,
-0.005390109494328499,
-0.02901451103389263,
-0.012916218489408493,
-0.021823523566126823,
-0.008969943970441818,
0.023326866328716278,
0.027160389348864555,
0.024880319833755493,
-0.02600782737135887,
0.011531890369951725,
0.011506834998726845,
0.04224392771720886,
0.005515388213098049,
-0.005853640381246805,
-0.01076769083738327,
0.005794133059680462,
-0.04898391291499138,
0.013642833568155766,
0.01560970675200224,
0.0033762569073587656,
0.0048514120280742645,
-0.0157850980758667,
-0.021660661324858665,
0.004156115930527449,
-0.0389866828918457,
0.06594663113355637,
-0.02434162236750126,
0.024253927171230316,
-0.012421367689967155,
0.01366788987070322,
-0.019368063658475876,
-0.023001141846179962,
-0.046353064477443695,
-0.02683466486632824,
0.005681382026523352,
-0.020395347848534584,
0.009364571422338486,
-0.02276311255991459,
0.015697402879595757,
0.05442100018262863,
0.043196044862270355,
0.06750008463859558,
-0.035403717309236526,
0.0030223450157791376,
0.01872914284467697,
0.003921218682080507,
0.03908690810203552,
-0.030016740784049034,
-0.007842437364161015,
-0.004140456207096577,
0.009057639166712761,
-0.017789553850889206,
-0.030367519706487656,
0.0036236820742487907,
-0.006896584294736385,
0.010943081229925156,
0.027836892753839493,
0.021623076871037483,
-0.0068777925334870815,
-0.0005500511033460498,
0.00044278136920183897,
0.02816261723637581,
-0.016223572194576263,
0.020395347848534584,
0.025882547721266747,
0.005386977456510067,
-0.058730583637952805,
-0.022387277334928513,
0.03139480575919151,
-0.052767325192689896,
-0.0006608443218283355,
-0.03212141990661621,
0.01934300735592842,
0.0387110710144043,
0.029365291818976402,
0.006166836712509394,
0.04114147648215294,
-0.023151475936174393,
0.017601635307073593,
-0.009051375091075897,
0.06845220178365707,
0.015133649110794067,
0.013893391005694866,
-0.04028958082199097,
0.01588531956076622,
0.042444370687007904,
-0.03838534653186798,
0.02321411482989788,
-0.03212141990661621,
-0.05121387168765068,
-0.031695473939180374,
-0.012490271590650082,
0.012621813453733921,
0.026233328506350517,
0.00225814594887197,
0.005258567165583372,
0.0031335297971963882,
-0.004544479306787252,
-0.01415647566318512,
-0.017626691609621048,
-0.04159247875213623,
0.04873335734009743,
-0.009214237332344055,
0.010955609381198883,
0.009320723824203014,
-0.011744864284992218,
-0.03292320296168327,
0.06404239684343338,
0.04189314693212509,
0.005192795768380165,
-0.013905919156968594,
-0.055373117327690125,
0.03507799282670021,
0.013304581865668297,
-0.006577123887836933,
0.009596336632966995,
-0.0018556885188445449,
0.009170389734208584,
0.008118050172924995,
0.01193904597312212,
0.011820031329989433,
0.019317952916026115,
0.00868180301040411,
-0.011275069788098335,
-0.0008949586190283298,
-0.004798168316483498,
0.01280346792191267,
0.009107750840485096,
-0.005108232609927654,
0.020032040774822235,
-0.01904233917593956,
-0.04256965219974518,
0.02866373211145401,
0.06163704767823219,
0.05156465247273445,
0.0007160452078096569,
0.02341456152498722,
-0.05657579377293587,
-0.052566878497600555,
-0.026158161461353302,
0.00548720033839345,
0.05186532065272331,
-0.00888851284980774,
-0.03931240737438202,
0.04392265900969505,
0.036431003361940384,
0.007554296404123306,
0.022687945514917374,
0.006007106509059668,
0.055573564022779465,
0.026809608563780785,
0.018115278333425522,
-0.023026198148727417,
-0.009408419020473957,
0.022487498819828033,
0.021660661324858665,
0.00299102533608675,
-0.08128072321414948,
0.011995420791208744,
-0.02102174051105976,
-0.01560970675200224,
-0.001663072733208537,
-0.0404399149119854,
-0.02255013957619667,
0.05707690864801407,
0.013805695809423923,
0.09140323102474213,
0.04226898401975632,
-0.02861362136900425,
-0.03074335679411888,
-0.03282298147678375,
-0.027210500091314316,
-0.002212732331827283,
0.012728300876915455,
0.0053024147637188435,
0.022525083273649216,
0.02032018080353737,
0.041467200964689255,
0.015947958454489708,
0.005518520250916481,
0.021309880539774895,
0.04359693452715874,
-0.005950731225311756,
0.01583520881831646,
-0.01135023683309555,
-0.0015965185593813658,
0.05727735161781311,
-0.014807924628257751,
0.021810995414853096,
0.017376134172081947,
-0.018340779468417168,
0.03778401017189026,
-0.04236920550465584,
0.014858036302030087,
-0.01806516759097576,
0.02743600308895111,
-0.020758654922246933,
-0.020595792680978775,
-0.02346467226743698,
-0.044223327189683914,
0.009915797039866447,
0.024166231974959373,
0.011600793339312077,
-0.0035453829914331436,
0.004613382741808891,
0.011080888099968433,
0.02575726993381977,
-0.03139480575919151,
0.03420104458928108,
0.00529615068808198,
0.019743898883461952,
0.036631446331739426,
-0.06409250199794769,
0.0071158213540911674,
-0.048182129859924316,
0.05111364647746086,
0.0057659451849758625,
-0.029615849256515503,
0.020395347848534584,
-0.01593543216586113,
0.006292114965617657,
0.0404399149119854,
-0.014206587336957455,
-0.004315846133977175,
-0.014369449578225613,
0.020169846713542938,
-0.06394217163324356,
0.03375004231929779,
0.009276876226067543,
0.019994456321001053,
-0.018240556120872498,
0.01613587699830532,
-0.02454206719994545,
-0.007485393434762955,
0.0392121858894825,
0.06138648837804794,
-0.03547888621687889,
0.021522855386137962,
-0.013191831298172474,
0.01217081118375063,
-0.015547067858278751,
-0.04840763285756111,
-0.0024304038379341364,
0.04853291064500809,
0.031595248728990555,
0.004472444299608469,
0.00967150367796421,
-0.013179303146898746,
-0.020044567063450813,
0.0010836594738066196,
-0.05146442726254463,
-0.041567422449588776,
-0.005023669917136431,
0.058730583637952805,
0.10844111442565918,
0.0024053482338786125,
0.016887549310922623,
-0.037809066474437714,
0.03217153251171112,
-0.019167618826031685,
-0.03242208808660507,
0.005217851605266333,
-0.013492499478161335,
-0.005925675388425589,
-0.0060384259559214115,
-0.005293018650263548,
0.023351920768618584,
0.022988613694906235,
0.028137562796473503,
0.007748478092253208,
0.021673189476132393,
0.049459971487522125,
0.004942238796502352,
0.04099114239215851,
0.07336311787366867,
0.003586098551750183,
0.03131963685154915,
-0.01970631629228592,
-0.015071009285748005,
-0.02102174051105976,
0.029665959998965263,
0.018265612423419952,
-0.000879298837389797,
-0.020295124500989914,
-0.0355289950966835,
-0.0404399149119854,
-0.008030354976654053,
-0.007610671687871218,
-0.005759681109338999,
-0.011851350776851177,
0.002568210242316127,
0.013655361719429493,
0.01175739150494337,
0.0054621449671685696,
-0.037558507174253464,
-0.011995420791208744,
-0.04923446848988533,
-0.01705040968954563,
-0.058780696243047714,
0.005277358926832676,
-0.006527012214064598,
0.011037040501832962,
0.0024382336996495724,
-0.03427620977163315,
0.01339227706193924,
-0.02485526353120804,
-0.010379327461123466,
-0.025343850255012512,
-0.023865563794970512,
-0.009145334362983704,
-0.022938502952456474,
-0.008218272589147091,
0.003529723035171628,
0.022838279604911804,
0.03450171276926994,
0.006508220452815294,
-0.0030599285382777452,
0.007948923856019974,
-0.05492211505770683,
0.04246942698955536,
-0.0532684400677681,
0.02266288921236992,
0.029390348121523857,
0.002272239653393626,
-0.0017351078568026423,
0.0207210723310709,
-0.02658410742878914,
-0.040189359337091446,
-0.01379316858947277,
0.005177136044949293,
0.009402154944837093,
0.03152008354663849,
-0.006451845169067383,
-0.02291344664990902,
0.008437510579824448,
0.02321411482989788,
-0.033173758536577225,
-0.03267264738678932,
0.030367519706487656,
-0.015033425763249397,
-0.02097162976861,
-0.02866373211145401,
-0.03936251997947693,
0.03074335679411888,
0.01832825131714344,
-0.01914256252348423,
0.01280346792191267,
0.030317408964037895,
-0.004873335361480713,
-0.00706571014598012,
0.023740284144878387,
-0.0009419380803592503,
0.030918745324015617,
-0.0027310724835842848,
0.02153538167476654,
-0.027260612696409225,
-0.044924888759851456,
-0.01603565365076065,
0.006041557993739843,
0.06639762967824936,
0.0017805213574320078,
0.034601934254169464,
-0.008813345804810524,
-0.01720074564218521,
0.02189869061112404,
0.029290124773979187,
-0.019530925899744034,
-0.03640594705939293,
0.008024090901017189,
0.010354272089898586,
-0.02010720781981945,
-0.01487056352198124,
-0.0392121858894825,
-0.026959944516420364,
0.04036474972963333,
0.017802082002162933,
-0.007529240567237139,
-0.02434162236750126,
0.020232485607266426,
0.029691016301512718,
0.004344033543020487,
-0.015233871527016163,
-0.029816294088959694,
0.003980726003646851,
-0.00721604423597455,
-0.026458829641342163,
-0.02851339802145958,
0.019267840310931206,
-0.009352043271064758,
-0.049359750002622604,
-0.001749201794154942,
-0.03422610089182854,
-0.008280912414193153,
0.013279526494443417,
-0.06138648837804794,
0.012546646408736706,
0.004215623252093792,
-0.007948923856019974,
0.017852192744612694,
0.005001746118068695,
-0.015446845442056656,
-0.0144320884719491,
0.011556945741176605,
-0.01282852329313755,
-0.030066851526498795,
0.04194325953722,
0.011130998842418194,
-0.02846328541636467,
-0.010122506879270077,
0.01244642399251461,
0.0157850980758667,
-0.011863878928124905,
-0.037758953869342804,
0.004917182959616184,
0.0017977472161874175,
-0.02851339802145958,
0.0031319637782871723,
0.0036643976345658302,
-0.01633632369339466,
0.007948923856019974,
-0.03395048528909683,
0.008055410347878933,
0.030818523839116096,
0.004854543600231409,
-0.03592988848686218,
-0.010404383763670921,
0.0035579106770455837,
0.00827464833855629,
0.07551790773868561,
-0.012878634966909885,
0.009063903242349625,
-0.009665239602327347,
0.017689330503344536,
0.01175739150494337,
0.023790396749973297,
0.023965787142515182,
0.014820452779531479,
0.02113449200987816,
-0.01822802796959877,
0.08183194696903229,
0.0374833419919014,
-0.015071009285748005,
-0.02077118307352066,
0.016987770795822144,
-0.024654818698763847,
0.009045111015439034,
-0.01955598220229149,
-0.02876395545899868,
0.02449195645749569,
-0.04099114239215851,
0.001222248887643218,
-0.043296266347169876,
-0.07331300526857376,
-0.008763234131038189,
0.0004388664092402905,
0.02989146113395691,
-0.021460214629769325,
0.008650483563542366,
0.004040233325213194,
-0.007955187931656837,
0.008644219487905502,
-0.02189869061112404,
-0.011369028128683567,
-0.014006141573190689,
0.00025310181081295013,
-0.02683466486632824,
-0.0350278839468956,
-0.024567123502492905,
-0.0034952715504914522,
0.022487498819828033,
-0.009965908713638783,
0.04745551571249962,
-0.03788423165678978,
-0.015158704482018948,
-0.013768112286925316,
-0.012271033599972725,
-0.03517821803689003,
0.015133649110794067,
0.00192459172103554,
-0.010016020387411118,
0.018616393208503723,
-0.017388662323355675,
-0.025832436978816986,
-0.016737213358283043,
0.010523398406803608,
-0.005023669917136431,
0.026383662596344948,
0.02291344664990902,
0.022738056257367134,
-0.00768583919852972,
0.012020477093756199,
-0.01568487472832203,
-0.005772209260612726,
0.0202199574559927,
0.027686558663845062,
-0.04041485860943794,
0.04256965219974518,
-0.007071974221616983,
-0.009157861582934856,
0.007278683595359325,
0.0009912665700539947,
-0.02153538167476654,
-0.02836306393146515,
-0.011970365419983864,
0.036831893026828766,
-0.013016440905630589,
-0.025130877271294594,
0.0023943863343447447,
0.020232485607266426,
0.03620550036430359,
-0.032497256994247437,
-0.043697159737348557,
0.004090344533324242,
-0.008995000272989273,
0.02311389148235321,
0.04206853732466698,
0.0037395646795630455,
-0.0026731309480965137,
-0.017701858654618263,
0.012477743439376354,
0.009846894070506096,
-0.002140697091817856,
0.0025259286630898714,
-0.004560139030218124,
-0.04096608608961105,
0.0027843157295137644,
-0.0038022040389478207,
-0.019794011488556862,
-0.017288438975811005,
0.01351755578070879,
0.009427211247384548,
0.011206165887415409,
-0.024867791682481766,
0.0005594470421783626,
0.0024413657374680042,
0.01879178173840046,
0.0007622416596859694,
0.026283439248800278,
-0.020758654922246933,
-0.01529651042073965,
-0.015033425763249397,
0.006235739681869745,
-0.031845808029174805,
0.020583266392350197,
0.02067095972597599,
-0.024667346850037575,
0.006984279025346041,
-0.028839122503995895,
0.018754199147224426,
0.014820452779531479,
-0.014607478864490986,
-0.01568487472832203,
0.014720229431986809,
-0.031244469806551933,
-0.0043502976186573505,
0.0008166595362126827,
0.031645361334085464,
-0.016561824828386307,
0.005505992099642754,
-0.02600782737135887,
0.04028958082199097,
-0.023051252588629723,
0.013329637236893177,
-0.018315723165869713,
0.018290668725967407,
0.02896440029144287,
-0.10002239048480988,
-0.005546707659959793,
-0.004791904706507921,
-0.019831594079732895,
-0.008669275790452957,
0.023765340447425842,
-0.02851339802145958,
0.03254736587405205,
-0.013229414820671082,
-0.001410949626006186,
0.005011141765862703,
-0.010485814884305,
0.020708544179797173,
-0.01639896258711815,
-0.01879178173840046,
0.020094679668545723,
-0.0021203395444899797,
-0.02876395545899868,
0.008124314248561859,
-0.018340779468417168,
-0.01379316858947277,
0.017075465992093086,
-0.0038241276051849127,
0.07952681928873062,
-0.018716614693403244,
0.03014201857149601,
-0.009364571422338486,
-0.0028500868938863277,
-0.012158283032476902,
0.00024331442546099424,
0.0241787601262331,
0.014219115488231182,
0.027962172403931618,
-0.008976208046078682,
0.010705051943659782,
-0.004798168316483498,
0.001487682806327939,
-0.010855386033654213,
-0.004055893048644066,
-0.012546646408736706,
0.0019151958404108882,
0.010034811682999134,
-0.010523398406803608,
0.01175739150494337,
0.013379748910665512,
0.008581580594182014,
-0.025644518435001373,
-0.008663011714816093,
0.012220922857522964,
0.004168643616139889,
0.01539673376828432,
0.013981086201965809,
0.0011713544372469187,
0.016073238104581833,
0.0028422570321708918,
0.015446845442056656,
-0.02037029154598713,
0.015083537437021732,
0.0053024147637188435,
-0.0023176532704383135,
-0.02758633717894554,
0.024253927171230316,
0.061837490648031235,
-0.0071158213540911674,
-0.029590792953968048,
-0.013905919156968594,
-0.05647556856274605,
0.01869156025350094,
-0.04675395414233208,
0.0011901461984962225,
0.01832825131714344,
0.00507691316306591,
-0.007403962314128876,
0.02600782737135887,
-0.02275058440864086,
0.042494483292102814,
-0.012747092172503471,
-0.030217185616493225,
-0.039738357067108154,
0.002532192738726735,
0.015471900813281536,
-0.020182374864816666,
-0.0062012881971895695,
0.010009756311774254,
-0.0023348790127784014,
0.02052062563598156,
0.025619463995099068,
0.018967172130942345,
0.005963258910924196,
-0.02163560502231121,
0.003871107241138816,
0.012383784167468548,
-0.003604890312999487,
0.012521591037511826,
0.015058481134474277,
-0.002193940570577979,
-0.01756405271589756,
-0.0018901401199400425,
0.0003617418115027249,
-0.023602478206157684,
0.0367567278444767,
-0.0799277126789093,
0.012026741169393063,
-0.006564595736563206,
-0.007554296404123306,
-0.02193627320230007,
0.023865563794970512,
-0.02728566713631153,
-0.01857880875468254,
-0.044674329459667206,
0.01807769387960434,
-0.009909532964229584,
0.04497499763965607,
0.014331866055727005,
-0.01618598774075508,
-0.008606635965406895,
0.02112196385860443,
-0.02826284058392048,
0.007873756811022758,
-0.012252242304384708,
0.05742768570780754,
0.009690295904874802,
-0.013129191473126411,
-0.018866948783397675,
-0.0327979251742363,
-0.0005480936379171908,
-0.017488885670900345,
0.021560437977313995,
-0.011187374591827393,
0.029866406694054604,
0.0026966207660734653,
0.017037883400917053,
-0.002275371691212058,
-0.017125576734542847,
0.011932781897485256,
0.024316566064953804,
0.026358606293797493,
-0.0010938383638858795,
0.005142684560269117,
0.017125576734542847,
-0.0035610427148640156,
-0.0030270428396761417,
0.04813201725482941,
-0.009571281261742115,
0.05021164193749428,
-0.015008370392024517,
0.004829488229006529,
0.03224669769406319,
-0.003680057357996702,
0.026959944516420364,
-0.036431003361940384,
0.007447809912264347,
0.030167074874043465,
0.02255013957619667,
-0.001590254600159824,
0.040139246731996536,
-0.00783617328852415,
-0.024203816428780556,
-0.03608022257685661,
0.017300967127084732,
-0.019994456321001053,
0.08098005503416061,
-0.003344937227666378,
-0.015922904014587402,
0.04602733999490738,
-0.030417632311582565,
-0.005177136044949293,
-0.017701858654618263,
0.04377232491970062,
0.01944323070347309,
0.006871528457850218,
-0.0700557678937912,
0.015434317290782928,
-0.028688788414001465,
-0.01787724904716015,
0.013479972258210182,
0.015221343375742435,
0.01777702569961548,
0.012696980498731136,
-0.00036448228638619184,
-0.055423229932785034,
-0.003335541347041726,
0.01904233917593956,
0.005045593716204166,
0.028062395751476288,
0.027110278606414795,
-0.011093415319919586,
-0.02077118307352066,
0.017551524564623833,
0.0009215803002007306,
-0.00528362300246954,
-0.018653975799679756,
0.02042040415108204,
0.049409858882427216,
0.026609163731336594,
-0.03069324418902397,
-0.008468830026686192,
0.014682645909488201,
-0.0495852492749691,
-0.023502256721258163,
-0.05422055721282959,
0.025331322103738785,
0.058580249547958374,
-0.03497777134180069,
-0.024529539048671722,
0.012941273860633373,
0.004134192131459713,
-0.02504318207502365,
0.0026981867849826813,
0.0221993587911129,
0.006207552272826433,
0.052616991102695465,
-0.028187673538923264,
0.038610849529504776,
0.003164849244058132,
-0.010629884898662567,
-0.01183882262557745,
0.010473286733031273,
-0.008099257946014404,
-0.008493885397911072,
-0.0227004736661911,
-0.03029235266149044,
0.019743898883461952,
-0.030868634581565857,
-0.003329277504235506,
0.000049817797844298184,
0.03542877361178398,
0.01950586959719658,
0.002630849601700902,
0.022537611424922943,
-0.03705739602446556,
0.010504606179893017,
0.027962172403931618,
-0.0034921395126730204,
0.009026319719851017,
0.010667468421161175,
-0.026483885943889618,
-0.014319337904453278,
0.008237064816057682,
-0.00009811855125008151,
0.052216097712516785,
0.011738600209355354,
0.006859000772237778,
-0.02183605171740055,
0.0003075196873396635,
-0.012415104545652866,
0.04109136387705803,
-0.04775618389248848,
-0.009214237332344055,
-0.005991446785628796,
0.001844726619310677,
0.01691260375082493,
0.010398119688034058,
0.013943502679467201,
0.03415093198418617,
0.002280069515109062,
0.005925675388425589,
0.022362221032381058,
0.01379316858947277,
0.0014822018565610051,
-0.04567655920982361,
-0.0031382276210933924,
-0.007930132560431957,
-0.030718300491571426,
0.014782868325710297,
-0.01618598774075508,
0.004650966264307499,
-0.01573498547077179,
0.0008949586190283298,
-0.0023943863343447447,
-0.002568210242316127,
-0.0004130277084186673,
-0.006639763247221708,
-0.00603529391810298,
-0.008268384262919426,
-0.021973857656121254,
0.04134191945195198,
0.00868180301040411,
0.027160389348864555,
-0.024667346850037575,
0.006758777890354395,
-0.005706437863409519,
0.01076769083738327,
-0.0028829725924879313,
-0.0005065951263532043,
0.010498342104256153,
-0.01089296955615282,
-0.025682102888822556,
-0.0021203395444899797,
0.012440159916877747,
-0.013755585066974163,
-0.02067095972597599,
0.0025885680224746466,
-0.01761416345834732,
0.00756056047976017,
-0.020908989012241364,
0.0016568087739869952,
-0.009821838699281216,
0.023001141846179962,
-0.012484007515013218,
-0.011594529263675213,
0.02545660175383091,
0.014945730566978455,
-0.027836892753839493,
-0.0035359871108084917,
-0.012039268389344215,
-0.021046796813607216,
-0.010999456979334354,
0.0010186712024733424,
-0.00853146892040968,
-0.019480815157294273,
0.030618077144026756,
-0.011669697239995003,
-0.010698787868022919,
0.01133144460618496,
0.00617310032248497,
-0.008763234131038189,
-0.0027952776290476322,
0.03262253478169441,
0.02015731856226921,
-0.002734204288572073,
-0.0011721374467015266,
0.011343972757458687,
0.00937083549797535,
-0.022086607292294502,
-0.021397575736045837,
0.01285357866436243,
0.01822802796959877,
0.015008370392024517,
-0.0033042216673493385,
0.0010993193136528134,
0.015334093943238258,
0.009458530694246292,
-0.008362343534827232,
0.003620550036430359,
-0.00964644830673933,
0.017802082002162933,
0.004791904706507921,
0.007034390699118376,
-0.029315181076526642,
-0.01560970675200224,
0.027987228706479073,
-0.0036581335589289665,
-0.0059569948352873325,
0.01036053616553545,
0.012978857383131981,
-0.01796494424343109,
-0.02836306393146515,
-0.027686558663845062,
-0.027461057528853416,
0.0601838156580925,
-0.003363728988915682,
-0.038260068744421005,
0.022036496549844742,
0.015471900813281536,
0.006677346769720316,
0.012659396976232529,
0.020069623365998268,
0.003498403588309884,
0.015409261919558048,
-0.027160389348864555,
0.038460515439510345,
0.033073537051677704,
-0.006082273554056883,
-0.005593687295913696,
0.015346622094511986,
0.009696559980511665,
-0.013818223960697651,
0.015033425763249397,
0.012358728796243668,
0.014607478864490986,
-0.026659274473786354,
0.029916517436504364,
0.03517821803689003,
-0.01539673376828432,
0.007911340333521366,
0.007648255210369825,
0.016887549310922623,
0.007829909212887287,
0.03277286887168884,
0.005640666466206312,
-0.025331322103738785,
-0.0073287952691316605,
-0.01806516759097576,
0.01415647566318512,
-0.017476357519626617,
-0.03004179522395134,
0.003701981157064438,
0.012233450077474117,
-0.023026198148727417,
-0.012891163118183613,
-0.021059324964880943,
0.01074263546615839,
0.00003591970744309947,
-0.019881704822182655,
-0.0005942900897935033,
0.009283140301704407,
0.023552367463707924,
0.021247241646051407,
-0.020833821967244148,
-0.018466057255864143,
-0.010216465219855309,
0.012891163118183613,
-0.012477743439376354,
0.007071974221616983,
0.005386977456510067,
0.023965787142515182,
0.04104125127196312,
0.0018118410371243954,
0.0036675294395536184,
-0.021209659054875374,
-0.04617767408490181,
-0.05732746422290802,
-0.008393662981688976,
-0.008644219487905502,
-0.007880020886659622,
0.01864144764840603,
0.00794265978038311,
-0.03608022257685661,
-0.008669275790452957,
0.006527012214064598,
0.014482200145721436,
-0.01208938006311655,
-0.005195927806198597,
0.000977955642156303,
-0.011356500908732414,
0.0003441245062276721,
0.016787325963377953,
-0.013141719624400139,
-0.014895619824528694,
-0.012233450077474117,
-0.00020514361676760018,
0.01648665778338909,
0.0067462497390806675,
-0.023176532238721848,
-0.006426789332181215,
0.01425669901072979,
0.0244293175637722,
-0.016474129632115364,
0.010147562250494957,
-0.0018165389774367213,
0.01183882262557745,
0.04394771531224251,
-0.00705318246036768,
-0.01792735978960991,
-0.017438774928450584,
0.00990326888859272,
-0.03768378868699074,
0.019029811024665833,
0.010548453778028488,
0.027511170133948326,
0.0044317287392914295,
0.015484428964555264,
-0.021359993144869804,
-0.014369449578225613,
0.0010672166245058179,
-0.00046157315955497324,
-0.011105943471193314,
0.028087450191378593,
0.005418297369033098,
-0.009558753110468388,
-0.03131963685154915,
-0.0048670717515051365,
-0.000879298837389797,
0.02974112704396248,
0.07140877097845078,
0.01026031281799078,
-0.007222308311611414,
-0.014244170859456062,
0.01711305044591427,
0.03740817308425903,
-0.012509062886238098,
0.049008969217538834,
0.0030395707581192255,
0.019581036642193794,
-0.014695174060761929,
0.028538454324007034,
0.0037552244029939175,
0.001844726619310677,
0.0332990400493145,
-0.03044268675148487,
-0.012778411619365215,
-0.009458530694246292,
-0.011970365419983864,
0.016123348847031593,
0.01160705741494894,
0.020908989012241364,
-0.021861106157302856,
0.021259769797325134,
-0.029415402561426163,
-0.000614256365224719,
0.002021682681515813,
-0.01109967939555645,
-0.010554717853665352,
-0.007861228659749031,
0.004973558243364096,
-0.01259675808250904,
-0.01499584224075079,
0.014469671994447708,
0.02347720041871071,
-0.04174281284213066,
-0.008731914684176445,
0.016737213358283043,
-0.012715772725641727,
-0.0012097209692001343,
0.005186532158404589,
-0.039588022977113724,
-0.041567422449588776,
-0.0038147317245602608,
0.02097162976861,
-0.014569895341992378,
-0.004550743382424116,
0.004156115930527449,
0.0340256541967392,
0.028137562796473503,
-0.004293922334909439,
-0.009565017186105251,
0.02743600308895111,
0.021197130903601646,
0.011112207546830177,
0.017651747912168503,
-0.004892127122730017,
-0.0008965246379375458,
-0.03222164139151573,
-0.03244714438915253,
-0.01914256252348423,
-0.014933203347027302,
0.049610305577516556,
-0.032296810299158096,
0.003517195349559188,
0.002918990096077323,
-0.015058481134474277,
0.01691260375082493,
0.03497777134180069,
-0.014068781398236752,
0.019130034372210503,
-0.015071009285748005,
-0.004127928055822849,
-0.0034639518707990646,
-0.015359150245785713,
-0.014770341105759144,
-0.0001953562314156443,
-0.005393241532146931,
0.005036197602748871,
0.0007411009282805026,
0.012245978228747845,
0.02103426866233349,
-0.04084080830216408,
-0.029665959998965263,
-0.021322408691048622,
0.007767269853502512,
0.004904655274003744,
-0.0020577001851052046,
-0.00585677195340395,
0.004547611344605684,
-0.024053482338786125,
0.004369089379906654,
-0.018566280603408813,
-0.048031795769929886,
-0.0008370173163712025,
-0.02748611383140087,
0.01944323070347309,
-0.00019486686505842954,
-0.0022518818732351065,
-0.008844665251672268,
0.02653399668633938,
-0.025381434708833694,
-0.0037395646795630455,
-0.013467444106936455,
-0.014883091673254967,
-0.013505027629435062,
-0.009207973256707191,
-0.0003333583881612867,
-0.047981683164834976,
0.017802082002162933,
0.018215501680970192,
-0.005875564180314541,
-0.004910919349640608,
0.00880708172917366,
-0.012408840470016003,
-0.027110278606414795,
-0.035103049129247665,
-0.033173758536577225,
-0.021159546449780464,
-0.008882248774170876,
0.00783617328852415,
-0.03054291009902954,
0.0004987652064301074,
0.020758654922246933,
0.004657229874283075,
-0.07140877097845078,
-0.00580352870747447,
-0.014782868325710297,
-0.007441545836627483,
-0.010429439134895802,
0.033524539321660995,
-0.00507691316306591,
0.022186830639839172,
-0.017689330503344536,
-0.01716316118836403,
-0.03916207328438759,
0.016975242644548416,
0.007679575122892857,
-0.005747153423726559,
-0.0008487621671520174,
-0.037232786417007446,
-0.0117135439068079,
-0.033724986016750336,
-0.024629762396216393,
-0.009815574623644352,
-0.017889777198433876,
0.008349815383553505,
0.006354754325002432,
-0.000099390912509989,
-0.005033065564930439,
0.0017789553385227919,
-0.03946274146437645,
-0.03838534653186798,
-0.04372221231460571,
0.0433964878320694,
0.0109744006767869,
0.011156055144965649,
-0.023702701553702354,
0.0002936215896625072,
0.014231642708182335,
0.030317408964037895,
-0.024103593081235886,
-0.012690717354416847,
0.02999168448150158,
-0.020608320832252502,
0.015973014757037163,
0.013655361719429493,
-0.009220501407980919,
-0.00419996352866292,
-0.01644907332956791,
-0.011268805712461472,
0.004124796018004417,
0.01076769083738327,
-0.014845508150756359,
-0.001940251560881734,
-0.00007051812281133607,
0.0070030707865953445,
0.017376134172081947,
0.008255856111645699,
-0.022362221032381058,
0.030718300491571426,
0.020194903016090393,
-0.009684031829237938,
0.008669275790452957,
-0.015960486605763435,
-0.016223572194576263,
-0.009715351276099682,
-0.0024131780955940485,
0.00122459779959172,
0.023489728569984436,
-0.018453530967235565,
0.011130998842418194,
-0.001232427777722478,
-0.03590483218431473,
-0.0005300848861224949,
0.010454494506120682,
0.009352043271064758,
-0.006248267833143473,
0.031169302761554718,
0.013780640438199043,
0.027410946786403656,
0.0020044567063450813,
0.026408718898892403,
-0.009276876226067543,
0.030517853796482086,
-0.03665650263428688,
-0.007811117451637983,
-0.010047339834272861,
-0.0011870142770931125,
0.12076852470636368,
0.009026319719851017,
0.022487498819828033,
0.021547909826040268,
-0.0017131841741502285,
-0.030768411234021187,
0.02138504758477211,
0.02251255512237549,
-0.01130638923496008,
0.002229958074167371,
0.009433474391698837,
0.017488885670900345,
0.02678455412387848,
0.014582423493266106,
-0.007786061614751816,
-0.021823523566126823,
0.00769836688414216,
0.03931240737438202,
-0.02030765265226364,
-0.022637832909822464,
-0.01051087025552988,
-0.0008049146854318678,
-0.022011440247297287,
-0.008512677624821663,
-0.023189058527350426,
0.004112268332391977,
0.0037364326417446136,
0.030968857929110527,
-0.02414117567241192,
-0.03126952424645424,
0.0035704385954886675,
0.023502256721258163,
0.0259076040238142,
-0.0023145212326198816,
0.0023677644785493612,
-0.02092151716351509,
-0.019931817427277565,
-0.009082694537937641,
0.001858820440247655,
0.03462699055671692,
-0.011851350776851177,
-0.0035798344761133194,
-0.012402576394379139,
-0.008919832296669483,
0.004059025086462498,
0.001136902836151421,
-0.04236920550465584,
-0.001667770673520863,
0.009652712382376194,
0.00061229889979586,
-0.0056030829437077045,
0.002637113444507122,
0.013229414820671082,
0.0012895860709249973,
-0.04382243752479553,
-0.02113449200987816,
0.0023145212326198816,
-0.005693910177797079,
-0.00585677195340395,
-0.012878634966909885,
-0.014895619824528694,
0.017626691609621048,
-0.007466601673513651,
-0.020094679668545723,
-0.005502860061824322
] | 2025-01-08 | 1 | 39774788 | [
"Pulmonary comorbidity measures",
"pulmonary comorbidity level",
"hematopoietic cell transplantation",
"Pre-therapy PFT",
"Pulmonary function tests",
"Categorical FEV1",
"reduced PFS",
"multivariable Cox regression",
"therapy efficacy",
"FEV1",
"continuous measure",
"overall survival",
"PFS",
"severe toxicities",
"progression free survival",
"overall response rates",
"cytokine release syndrome grade>2",
"B-cell lymphoma patients",
"patients",
"toxicities",
"toxicity",
"PFTs and pulmonary comorbidity classifications",
"PFT",
"logistic regression",
"forced expiratory volume",
"CI",
"cell-associated neurotoxicity",
"Spline modeling",
"immune effector",
"DLCO"
] | [] | 0 | 10.1182/bloodadvances.2024014488 | [
"Sdayoor",
"Shouval",
"Fried",
"Marcus",
"Danylesko",
"Yerushalmi",
"Shem-Tov",
"Itzhaki",
"Jacoby",
"Kedmi",
"Nagler",
"Shimoni",
"Segel",
"Avigdor"
] | [
"Chaim Sheba Medical Center, Ramat Gan, Israel.",
"Memorial Sloan Kettering Cancer Center, New York, New York, United States.",
"Chaim Sheba Medical Center, Ramat Gan, Israel.",
"Chaim Sheba Medical Center, Ramat Gan, Israel.",
"Chaim Sheba Medical Center, Ramat Gan, Israel.",
"Chaim Sheba Medical Center.",
"Chaim Sheba Medical Center.",
"Chaim Sheba Medical Center, Ramat Gan, Israel.",
"Sheba Medical Center, Tel Hashomer, Israel.",
"Chaim Sheba Medical Center, Ramat Gan, Israel.",
"Chaim Sheba Medical Center, Tel Hashomer, Israel.",
"Chaim Sheba Medical Center, Ramat Gan, Israel.",
"Chaim Sheba Medical Center, Ramat Gan, Israel.",
"Sheba Medical Center, Tel Hashomer, Israel."
] | [
"39774788"
] | [] | 6.137629 | 5.248068 |
39769449 | 62 | Current Non-Viral-Based Strategies to Manufacture CAR-T Cells. | The successful application of CAR-T cells in the treatment of hematologic malignancies has fundamentally changed cancer therapy. With increasing numbers of registered CAR-T cell clinical trials, efforts are being made to streamline and reduce the costs of CAR-T cell manufacturing while improving their safety. To date, all approved CAR-T cell products have relied on viral-based gene delivery and genomic integration methods. While viral vectors offer high transfection efficiencies, concerns regarding potential malignant transformation coupled with costly and time-consuming vector manufacturing are constant drivers in the search for cheaper, easier-to-use, safer, and more efficient alternatives. In this review, we examine different non-viral gene transfer methods as alternatives for CAR-T cell production, their advantages and disadvantages, and examples of their applications. Transposon-based gene transfer methods lead to stable but non-targeted gene integration, are easy to handle, and achieve high gene transfer rates. Programmable endonucleases allow targeted integration, reducing the potential risk of integration-mediated malignant transformation of CAR-T cells. Non-integrating CAR-encoding vectors avoid this risk completely and achieve only transient CAR expression. With these promising alternative techniques for gene transfer, all avenues are open to fully exploiting the potential of next-generation CAR-T cell therapy and applying it in a wide range of applications. | [
0.005442037247121334,
0.01437563356012106,
0.04023773968219757,
0.026879744604229927,
-0.04136065021157265,
-0.028306780382990837,
0.011849078349769115,
0.016691643744707108,
0.00550052197650075,
-0.026482045650482178,
0.009123673662543297,
-0.014726544730365276,
-0.014001329429447651,
-0.008386760950088501,
-0.012153200805187225,
-0.06484825909137726,
0.029265936464071274,
-0.01632903516292572,
0.008532973937690258,
0.005374779459089041,
0.02921914868056774,
0.04260053485631943,
-0.01715952344238758,
0.0002324782108189538,
-0.0258971955627203,
-0.035208020359277725,
0.014457512646913528,
0.012305261567234993,
-0.0383194275200367,
-0.04912747070193291,
0.013954541645944118,
-0.02224772609770298,
-0.01634073257446289,
-0.026669198647141457,
0.0026800790801644325,
0.07167931646108627,
0.05408700555562973,
0.00006424220919143409,
0.008304881863296032,
-0.0037839850410819054,
0.0546952523291111,
0.03838960826396942,
0.015334789641201496,
0.04646055027842522,
-0.043980784714221954,
0.005828038789331913,
-0.04110331833362579,
-0.0895523652434349,
-0.008205457590520382,
0.020364506170153618,
-0.01111216563731432,
-0.015042363665997982,
-0.040518466383218765,
-0.008573913015425205,
-0.050905417650938034,
0.01796661876142025,
-0.05263657495379448,
-0.022961243987083435,
0.005082353949546814,
0.017650797963142395,
0.009913221932947636,
-0.024821069091558456,
0.011737956665456295,
-0.026458652690052986,
-0.031114064157009125,
0.04000379890203476,
-0.04692843183875084,
-0.002688851673156023,
-0.014048117212951183,
0.04129046946763992,
0.002427130937576294,
-0.01758061721920967,
-0.00048725385568104684,
-0.0018642120994627476,
0.01692558266222477,
0.011457228101789951,
-0.02409585565328598,
0.03850657865405083,
0.030084727331995964,
-0.00014877143257763237,
0.052355848252773285,
-0.035418566316366196,
0.008924824185669422,
-0.010065282694995403,
-0.024587130174040794,
-0.02083238773047924,
0.008942369371652603,
-0.03064618445932865,
-0.01691388711333275,
-0.003924349322915077,
-0.045828912407159805,
0.03801530599594116,
-0.01232865545898676,
0.04311520606279373,
-0.002354024676606059,
0.038062091916799545,
-0.007790213450789452,
-0.037266697734594345,
0.03567590191960335,
0.032120008021593094,
0.04788758605718613,
0.012925203889608383,
0.021990392357110977,
0.017720980569720268,
0.06391250342130661,
0.00028566308901645243,
-0.02268051542341709,
-0.00587190268561244,
0.013100658543407917,
0.03130121901631355,
0.06812343001365662,
-0.028072841465473175,
-0.007257998920977116,
0.07359763234853745,
-0.029453089460730553,
-0.051092568784952164,
-0.018925772979855537,
0.013393084518611431,
0.0010600421810522676,
0.03200303763151169,
-0.037032756954431534,
-0.005196399986743927,
0.03219018876552582,
0.012983689084649086,
-0.001557165407575667,
-0.02673938125371933,
0.0416179858148098,
0.006942179519683123,
-0.0045413668267428875,
-0.06774912029504776,
0.028517326340079308,
0.013708903454244137,
0.022750698029994965,
-0.007211211137473583,
-0.08014795929193497,
0.003169891657307744,
-0.020259233191609383,
0.03576947748661041,
-0.016060004010796547,
0.018867287784814835,
-0.012878415174782276,
-0.024423372000455856,
-0.02959345281124115,
0.031441580504179,
-0.018001709133386612,
-0.03321952745318413,
0.007287241518497467,
0.02064523473381996,
-0.003672863356769085,
0.05525670945644379,
-0.008088487200438976,
0.017498737201094627,
0.028096234425902367,
0.0032488463912159204,
-0.020972751080989838,
-0.044565632939338684,
-0.024821069091558456,
0.08155160397291183,
-0.02002529241144657,
-0.04674128070473671,
-0.02037620358169079,
0.0027078595012426376,
-0.022516757249832153,
-0.041337259113788605,
-0.014831817708909512,
-0.012001139111816883,
0.010550709441304207,
-0.014972181990742683,
-0.07013531029224396,
-0.00950382649898529,
0.0026435258332639933,
-0.03583965823054314,
-0.04330235719680786,
-0.009334219619631767,
-0.029031995683908463,
-0.012843324802815914,
-0.01183153223246336,
0.003146497532725334,
-0.030903518199920654,
-0.02449355274438858,
0.016995765268802643,
0.01653958112001419,
0.03941894695162773,
-0.028072841465473175,
-0.01498387847095728,
-0.000552318524569273,
-0.02793247625231743,
0.010778801515698433,
-0.03038885071873665,
-0.037477243691682816,
-0.00041670622886158526,
-0.036635056138038635,
0.007667394820600748,
0.0011075612856075168,
0.019031045958399773,
0.007819456048309803,
0.05530349537730217,
0.02207227051258087,
0.018516378477215767,
-0.05651998519897461,
0.041126713156700134,
-0.042132653295993805,
-0.015089151449501514,
-0.00699481600895524,
-0.06278958916664124,
-0.054975979030132294,
-0.014410724863409996,
0.042764294892549515,
-0.020481476560235023,
-0.001011060900054872,
0.03064618445932865,
0.0310438834130764,
-0.027300838381052017,
0.03406171500682831,
-0.029125571250915527,
-0.005193475633859634,
0.02000189945101738,
0.06639226526021957,
0.019639290869235992,
0.03714972734451294,
-0.017487039789557457,
-0.027066897600889206,
-0.03151176497340202,
-0.005790023598819971,
-0.005462506785988808,
-0.008971611969172955,
-0.014445816166698933,
-0.03188606724143028,
0.029148966073989868,
-0.025827012956142426,
0.01234035287052393,
0.003968213219195604,
0.028727874159812927,
-0.03228376805782318,
-0.04428490623831749,
-0.022388091310858727,
0.025639861822128296,
-0.017299888655543327,
0.019463835284113884,
-0.015779275447130203,
0.0028628448490053415,
-0.005170081276446581,
-0.005342612508684397,
-0.03139479458332062,
-0.03102048859000206,
-0.013919450342655182,
-0.03445941209793091,
-0.06662620604038239,
0.0167150367051363,
0.006597117520868778,
-0.006339783314615488,
0.013439872302114964,
0.025218768045306206,
0.00275610969401896,
0.046858251094818115,
-0.0034915595315396786,
0.016621461138129234,
-0.02610774151980877,
0.05619246885180473,
0.000024650549676152878,
0.004044243600219488,
-0.006263752467930317,
-0.04833207279443741,
-0.015100848861038685,
-0.03389795497059822,
0.053946640342473984,
0.012141503393650055,
0.037641000002622604,
0.0006488189101219177,
0.009293279610574245,
0.06087127700448036,
-0.020785599946975708,
0.024821069091558456,
0.004254790022969246,
-0.07453339546918869,
0.004281108267605305,
0.001401448855176568,
0.025569679215550423,
0.00357636297121644,
0.0416179858148098,
-0.024821069091558456,
0.02165117859840393,
0.004567685071378946,
-0.0380387008190155,
-0.015077454969286919,
-0.017615707591176033,
0.015767578035593033,
0.022727303206920624,
0.009000854566693306,
-0.07401872426271439,
0.0065327840857207775,
0.013194235041737556,
-0.009843039326369762,
-0.03445941209793091,
0.03895106539130211,
0.0029213300440460443,
-0.007901335135102272,
-0.0010520004434511065,
-0.040518466383218765,
-0.015861155465245247,
-0.039512522518634796,
0.0023394033778458834,
-0.004020849708467722,
-0.040518466383218765,
-0.007848698645830154,
0.014831817708909512,
-0.0486128032207489,
-0.027675142511725426,
0.014024723321199417,
0.012667869217693806,
0.002583578694611788,
-0.003684560302644968,
0.03403832018375397,
-0.004754837602376938,
-0.006012266501784325,
0.05553743615746498,
-0.021674571558833122,
-0.07392514497041702,
0.017896436154842377,
-0.05436773598194122,
-0.016516188159585,
-0.0185631662607193,
0.010579952038824558,
0.013404780998826027,
0.03167552128434181,
-0.04510369896888733,
0.01355684269219637,
-0.032307159155607224,
0.03270485997200012,
0.0073983632028102875,
-0.01797831431031227,
-0.03345346823334694,
0.02755817212164402,
-0.02328876033425331,
-0.006901239976286888,
-0.00035913498140871525,
-0.030131515115499496,
-0.05942084640264511,
0.029897574335336685,
-0.00617602514103055,
-0.02613113634288311,
0.0396294929087162,
-0.005371855106204748,
0.05408700555562973,
-0.007854546420276165,
-0.012469019740819931,
-0.013428175821900368,
0.038062091916799545,
-0.013919450342655182,
0.017054250463843346,
0.01203623041510582,
0.008000759407877922,
0.016492793336510658,
0.01996680721640587,
0.018738621845841408,
0.04355969280004501,
-0.014504301361739635,
0.006953876465559006,
0.01574418507516384,
-0.024423372000455856,
-0.0057139927521348,
0.03595662862062454,
-0.043185386806726456,
0.03291540592908859,
0.03696257248520851,
0.05324482172727585,
-0.01758061721920967,
0.03022509254515171,
-0.025827012956142426,
-0.0334300734102726,
-0.007550424430519342,
-0.009386856108903885,
0.003017830429598689,
0.013311205431818962,
-0.019557412713766098,
0.015264607034623623,
0.014866908080875874,
0.02797926403582096,
0.027721930295228958,
0.004190456122159958,
0.04978250339627266,
-0.020306020975112915,
-0.04386381432414055,
-0.015568729490041733,
-0.017627405002713203,
0.0240490660071373,
0.008018305525183678,
0.009562311694025993,
-0.05450809746980667,
0.06246206909418106,
0.018902380019426346,
-0.0006415082607418299,
0.0020791448187083006,
-0.018843894824385643,
-0.04040149599313736,
0.0689656138420105,
-0.027909083291888237,
0.0546952523291111,
0.03548875078558922,
-0.009977555833756924,
0.012176594696938992,
-0.007170271594077349,
-0.05899975448846817,
-0.029125571250915527,
0.011585894972085953,
-0.04515048488974571,
0.040541861206293106,
0.04524406045675278,
0.010907468385994434,
0.004286956507712603,
0.015872852876782417,
0.03628414496779442,
0.03771118074655533,
0.007772667799144983,
0.028306780382990837,
-0.014001329429447651,
-0.03167552128434181,
0.0220605731010437,
-0.004962459206581116,
0.035418566316366196,
0.023791732266545296,
-0.0384363979101181,
-0.02613113634288311,
-0.02465731091797352,
-0.011275924742221832,
-0.01498387847095728,
0.005132066085934639,
0.025055009871721268,
-0.003637772286310792,
-0.041501015424728394,
-0.028213204815983772,
0.035020869225263596,
-0.004681731108576059,
-0.0388340950012207,
0.004880580119788647,
0.039068035781383514,
-0.005038490053266287,
0.03249431401491165,
0.007626454811543226,
0.0416179858148098,
-0.04355969280004501,
0.022388091310858727,
0.011445530690252781,
-0.01610679179430008,
0.013615327887237072,
-0.002818981185555458,
-0.03574608266353607,
0.02306651696562767,
-0.034389231353998184,
-0.02961684763431549,
-0.02840035781264305,
0.0016229611355811357,
-0.009416098706424236,
-0.013030476868152618,
-0.03392134979367256,
-0.014188481494784355,
0.012995385564863682,
-0.0713518038392067,
0.0029374132864177227,
0.010620891116559505,
-0.0006396805983968079,
-0.017042553052306175,
0.003921424970030785,
-0.02447015978395939,
0.008737671189010143,
0.03041224367916584,
0.0494082011282444,
-0.051747601479291916,
-0.0022604484111070633,
-0.014211875386536121,
0.009486280381679535,
-0.01630564220249653,
-0.018446195870637894,
0.001662438502535224,
-0.030692972242832184,
0.04414454102516174,
0.025639861822128296,
-0.007977365516126156,
-0.0010761255398392677,
0.014539391733705997,
-0.0015396198723465204,
0.01438733097165823,
0.0015600896440446377,
0.0016595142660662532,
0.01429375447332859,
0.020165657624602318,
0.011849078349769115,
-0.0012281867675483227,
-0.010585800744593143,
0.0031845129560679197,
0.024633917957544327,
-0.02835356816649437,
0.03190946206450462,
-0.009895676746964455,
-0.006801815237849951,
-0.009673433378338814,
-0.04526745527982712,
-0.000025884219212457538,
-0.03860015422105789,
0.025031616911292076,
-0.005108672194182873,
0.036026813089847565,
-0.02262203022837639,
0.005866053979843855,
0.07827644050121307,
0.05333839729428291,
0.037851545959711075,
0.03682221099734306,
-0.011077075265347958,
0.043583083897829056,
-0.017030857503414154,
-0.01112386304885149,
0.034786928445100784,
-0.005219793878495693,
-0.039489127695560455,
-0.010258283466100693,
-0.037641000002622604,
0.005117444787174463,
-0.019311774522066116,
-0.02248166687786579,
-0.012609384022653103,
-0.0066965422593057156,
-0.025195375084877014,
-0.0017443177057430148,
-0.010188101790845394,
-0.02222433127462864,
-0.0157207902520895,
-0.017487039789557457,
-0.0043395934626460075,
-0.05488240346312523,
0.03588644787669182,
0.014703149907290936,
-0.01019395049661398,
0.0066848453134298325,
-0.04105652868747711,
-0.028330175206065178,
-0.025242162868380547,
0.03682221099734306,
-0.02840035781264305,
0.006801815237849951,
-0.011047832667827606,
-0.009322522208094597,
0.03810888156294823,
-0.010813891887664795,
-0.019264986738562584,
-0.005371855106204748,
-0.00979625154286623,
-0.037851545959711075,
-0.006059054750949144,
-0.018013406544923782,
0.018422801047563553,
-0.027300838381052017,
0.02447015978395939,
-0.015615517273545265,
0.0347401387989521,
-0.013486660085618496,
-0.006006418261677027,
-0.016282247379422188,
-0.0022589864674955606,
-0.0014723619678989053,
0.0027897385880351067,
-0.02000189945101738,
0.024376582354307175,
-0.002158099552616477,
-0.0039009551983326674,
0.030131515115499496,
-0.0000861284279380925,
-0.013229326345026493,
-0.01815376989543438,
0.00749193923547864,
-0.022972941398620605,
-0.015416668727993965,
0.029640240594744682,
-0.022692212834954262,
0.038483183830976486,
0.017615707591176033,
0.008246396668255329,
-0.007205362431704998,
-0.01979135349392891,
0.017908133566379547,
-0.005202248226851225,
-0.03270485997200012,
-0.0008129426860250533,
0.026248106732964516,
0.008456943556666374,
0.0057549322955310345,
-0.05366591364145279,
0.0216628760099411,
-0.010269980877637863,
0.011422136798501015,
0.039301976561546326,
0.02286766842007637,
0.025171980261802673,
0.011813987046480179,
-0.04023773968219757,
0.01691388711333275,
0.016796916723251343,
0.001772098010405898,
-0.020306020975112915,
-0.0040413192473351955,
-0.024236219003796577,
-0.018422801047563553,
-0.002470994833856821,
-0.0480981320142746,
-0.01234035287052393,
0.018060194328427315,
-0.0006023963796906173,
-0.02037620358169079,
0.02059844695031643,
-0.019031045958399773,
0.0412202887237072,
0.005594098474830389,
-0.025148587301373482,
0.008170366287231445,
0.047653645277023315,
0.013205932453274727,
-0.030318668112158775,
-0.019241591915488243,
0.00648014759644866,
-0.048659589141607285,
-0.024376582354307175,
0.019463835284113884,
-0.0001409124961355701,
-0.013860965147614479,
0.006842754781246185,
-0.0027765794657170773,
0.012422231957316399,
-0.0005475666257552803,
0.008837096393108368,
-0.00019756992696784437,
-0.02041129395365715,
-0.03525481000542641,
-0.016282247379422188,
-0.0009935153648257256,
0.005342612508684397,
-0.011351955123245716,
0.024961434304714203,
-0.009813797660171986,
0.015557032078504562,
-0.01174380537122488,
-0.039886828511953354,
0.03583965823054314,
-0.0024929267819970846,
-0.0347401387989521,
0.0036904087755829096,
-0.005895296577364206,
-0.020282628014683723,
-0.01307726465165615,
0.030576001852750778,
-0.0028277537785470486,
-0.01737006939947605,
-0.024353189393877983,
0.03771118074655533,
-0.058063991367816925,
0.001987030729651451,
0.009369310922920704,
0.002482691779732704,
0.009509675204753876,
0.05081184208393097,
0.04936141148209572,
-0.016785219311714172,
0.011141408234834671,
0.003196209901943803,
-0.010556558147072792,
-0.02634168229997158,
-0.009609099477529526,
0.007205362431704998,
0.03321952745318413,
-0.02202548272907734,
0.009211400523781776,
0.02512519247829914,
0.045618366450071335,
-0.018282437697052956,
-0.01718291826546192,
-0.040916163474321365,
-0.004009152762591839,
0.014153390191495419,
-0.03165212646126747,
-0.017042553052306175,
0.02753477729856968,
-0.028283387422561646,
0.04079919680953026,
-0.04107992351055145,
0.008433549664914608,
0.021265177056193352,
-0.016668248921632767,
0.01143968291580677,
0.01875031739473343,
0.0009927842766046524,
-0.005863129626959562,
0.017299888655543327,
-0.011597592383623123,
-0.032564494758844376,
0.007211211137473583,
0.028891632333397865,
0.014515997841954231,
-0.0023481762036681175,
-0.00316111883148551,
-0.0038161517586559057,
-0.042132653295993805,
0.03102048859000206,
0.02182663418352604,
0.014165087603032589,
-0.018668439239263535,
0.028915025293827057,
-0.023791732266545296,
-0.011907563544809818,
-0.01691388711333275,
-0.0044390177354216576,
0.015463456511497498,
0.010065282694995403,
0.0030383002012968063,
-0.016036611050367355,
-0.03995700925588608,
0.0019080758793279529,
0.006292995065450668,
-0.000716076756361872,
0.005485901143401861,
0.03331310302019119,
0.015767578035593033,
0.0006685576518066227,
0.01859825663268566,
-0.022154150530695915,
0.005272430367767811,
-0.005327991209924221,
0.048659589141607285,
-0.03303237631917,
0.0766388550400734,
-0.01896086521446705,
-0.0367286317050457,
-0.0030032091308385134,
-0.011644380167126656,
-0.036658450961112976,
0.000645894673652947,
-0.007199513725936413,
0.024540342390537262,
-0.04517387971282005,
-0.014246966689825058,
0.002633290830999613,
-0.013884359039366245,
0.023850217461586,
-0.01430545188486576,
0.005608719773590565,
0.030061334371566772,
-0.03186267241835594,
0.02430640161037445,
0.03261128440499306,
-0.0006418738048523664,
0.008638246916234493,
-0.025990771129727364,
-0.0062754494138062,
0.007924729026854038,
-0.020563356578350067,
-0.03347686305642128,
0.023195184767246246,
-0.017089340835809708,
-0.01676182448863983,
-0.002251675818115473,
-0.029733816161751747,
-0.014726544730365276,
-0.044799573719501495,
0.008521276526153088,
0.001319569768384099,
-0.003134800586849451,
0.004096880089491606,
-0.021288570016622543,
0.009000854566693306,
0.03127782419323921,
-0.017405161634087563,
0.06732802838087082,
-0.01693728007376194,
0.004637867212295532,
-0.01102443877607584,
-0.008544670417904854,
-0.008655792102217674,
-0.0023627975024282932,
-0.012808233499526978,
0.01777946576476097,
-0.012539202347397804,
-0.0004031815624330193,
-0.033547043800354004,
0.036237359046936035,
-0.03293880075216293,
0.0030967851635068655,
-0.013088962063193321,
-0.013498357497155666,
-0.0027692688163369894,
0.02716047316789627,
-0.004558912478387356,
-0.007433454040437937,
0.01839940808713436,
0.03689239174127579,
-0.02428300678730011,
0.039114825427532196,
-0.02225942350924015,
0.007064998149871826,
0.03455298766493797,
-0.07228756695985794,
-0.018902380019426346,
-0.007573818322271109,
-0.019112925976514816,
0.025827012956142426,
0.026973320171236992,
-0.01163853146135807,
0.02204887755215168,
0.018282437697052956,
0.01714782603085041,
0.0009467272902838886,
-0.04454224184155464,
0.024002278223633766,
0.012679566629230976,
0.008492033928632736,
0.0006469912477768958,
-0.009790402837097645,
-0.06625190377235413,
0.025055009871721268,
0.02594398334622383,
-0.04433169588446617,
0.009749463759362698,
-0.0021961149759590626,
0.033968135714530945,
-0.0041056531481444836,
0.002462222008034587,
-0.013942844234406948,
-0.01735837385058403,
-0.04227301850914955,
-0.0027970492374151945,
0.003196209901943803,
-0.007895486429333687,
-0.02634168229997158,
0.013580236583948135,
-0.004243093077093363,
-0.029640240594744682,
0.021569298580288887,
0.0049039744772017,
0.012433929368853569,
0.017802860587835312,
-0.007924729026854038,
0.023569488897919655,
0.017861343920230865,
0.008199608884751797,
-0.03427226096391678,
-0.0012669331626966596,
-0.0010512693552300334,
-0.02043468877673149,
0.02652883529663086,
-0.007217059377580881,
0.03022509254515171,
-0.04716237261891365,
-0.030342061072587967,
-0.02737101912498474,
0.016855401918292046,
-0.01111216563731432,
-0.005339688155800104,
0.03441262245178223,
0.0037576667964458466,
0.017709283158183098,
-0.009240643121302128,
0.03897446021437645,
0.027277443557977676,
-0.01799001172184944,
-0.01173210795968771,
-0.019534017890691757,
-0.02428300678730011,
0.023312155157327652,
-0.06349141150712967,
0.013299508020281792,
-0.007053301203995943,
0.03146497532725334,
-0.03436583653092384,
0.002883314620703459,
-0.010691073723137379,
-0.0006513776024803519,
0.003871712600812316,
-0.006673148367553949,
-0.01673843152821064,
0.0062988437712192535,
-0.04472939297556877,
-0.03415529057383537,
-0.003134800586849451,
0.008416003547608852,
-0.03392134979367256,
0.016083398833870888,
-0.01438733097165823,
0.0018028027843683958,
0.022949546575546265,
-0.01174380537122488,
-0.00027378331287764013,
-0.02568664960563183,
-0.016656551510095596,
0.0004711704677902162,
-0.017510434612631798,
-0.01613018661737442,
-0.016855401918292046,
0.00597132695838809,
-0.023826822638511658,
-0.026060953736305237,
0.018937470391392708,
-0.033780984580516815,
0.01817716471850872,
-0.03366401419043541,
-0.041337259113788605,
0.016867099329829216,
0.027254048734903336,
-0.011188196949660778,
0.0031932855490595102,
-0.02921914868056774,
0.02676277421414852,
-0.0050531113520264626,
0.01795492134988308,
0.014153390191495419,
-0.011767199262976646,
0.01042204163968563,
0.03228376805782318,
-0.02797926403582096,
-0.008334124460816383,
0.012831627391278744,
0.06335104256868362,
0.02879805490374565,
-0.00463494285941124,
-0.016843704506754875,
-0.006199419032782316,
-0.02779211290180683,
-0.003626075340434909,
0.04529085010290146,
0.013790782541036606,
-0.029710423201322556,
-0.002748799044638872,
0.0002162120508728549,
0.020165657624602318,
0.008088487200438976,
-0.015276304446160793,
0.023113304749131203,
0.02000189945101738,
0.03272825479507446,
-0.017206311225891113,
0.016083398833870888,
-0.0006678265635855496,
-0.007059149909764528,
-0.0042577143758535385,
-0.024844463914632797,
0.042132653295993805,
0.00022589863510802388,
-0.04732612892985344,
0.02797926403582096,
-0.03443601727485657,
-0.0024373659398406744,
-0.008807853795588017,
0.055818166583776474,
0.012913506478071213,
0.07682600617408752,
-0.02303142659366131,
0.00957400817424059,
0.015790972858667374,
-0.018820500001311302,
-0.03555893152952194,
0.01835262030363083,
-0.013194235041737556,
0.03995700925588608,
-0.03490389883518219,
-0.018890682607889175,
0.034763533622026443,
0.013498357497155666,
-0.019931716844439507,
0.0067842695862054825,
0.04463581740856171,
-0.0008970149792730808,
-0.0018934545805677772,
-0.04465921223163605,
0.03209661319851875,
-0.005067732650786638,
-0.00734572671353817,
-0.016820309683680534,
0.022200938314199448,
0.01717122085392475,
0.0247041005641222,
0.021335359662771225,
-0.013100658543407917,
-0.0063690259121358395,
-0.008638246916234493,
0.03576947748661041,
0.02328876033425331,
-0.03775797039270401,
-0.015241213142871857,
-0.03022509254515171,
0.020762205123901367,
0.0011441144160926342,
-0.019639290869235992,
-0.02286766842007637,
-0.005316294264048338,
0.05820435658097267,
0.0006901239976286888,
-0.005731538403779268,
-0.039278581738471985,
-0.0027356399223208427,
-0.02634168229997158,
-0.028423750773072243,
-0.04959535226225853,
0.03368740901350975,
0.04327896237373352,
-0.002751723164692521,
-0.017019160091876984,
0.04503351449966431,
0.008211306296288967,
-0.01797831431031227,
0.0021288571879267693,
0.030552608892321587,
0.0237098541110754,
0.08099014312028885,
-0.030926913022994995,
0.0480981320142746,
-0.022388091310858727,
0.02389700524508953,
0.003324877005070448,
-0.0022692212369292974,
-0.03981664404273033,
-0.015638912096619606,
-0.08056905120611191,
0.0010044813388958573,
0.011474773287773132,
-0.035184625536203384,
0.0015951807145029306,
0.023978885263204575,
0.025546284392476082,
0.010983498767018318,
0.01376738864928484,
0.0005153997917659581,
-0.02875126712024212,
0.0063046920113265514,
0.0384363979101181,
-0.002805821830406785,
-0.018434498459100723,
0.00688369432464242,
-0.00469050370156765,
-0.03525481000542641,
0.010503921657800674,
-0.009679281152784824,
0.035231415182352066,
0.010673527605831623,
0.015533638186752796,
-0.037430454045534134,
-0.02349930629134178,
-0.009310825727880001,
0.04040149599313736,
-0.009071036241948605,
0.023008031770586967,
-0.007579667028039694,
-0.029640240594744682,
-0.005851432681083679,
0.013404780998826027,
0.0392317958176136,
0.05474203824996948,
0.01714782603085041,
0.02387361228466034,
0.01521781925112009,
0.01234035287052393,
0.005316294264048338,
-0.002049902221187949,
-0.0015293849864974618,
0.029850786551833153,
0.00004898125916952267,
0.02634168229997158,
0.0007705409661866724,
0.026669198647141457,
-0.013708903454244137,
0.03165212646126747,
0.023592883720993996,
0.008954066783189774,
0.037828151136636734,
-0.006907088682055473,
0.0025265556760132313,
-0.012106412090361118,
0.008263942785561085,
0.013088962063193321,
0.015018969774246216,
-0.013521751388907433,
0.01589624583721161,
-0.02059844695031643,
-0.025382526218891144,
-0.01841110549867153,
0.008878035470843315,
0.0021376297809183598,
0.007275544572621584,
-0.008720126003026962,
-0.020961053669452667,
0.005994721315801144,
-0.01632903516292572,
-0.004833792336285114,
0.005795871838927269,
-0.02737101912498474,
-0.018925772979855537,
-0.04238998889923096,
-0.01022319309413433,
0.005450809840112925,
0.0037138029001653194,
0.004266486968845129,
0.019557412713766098,
0.04000379890203476,
0.03637772426009178,
0.013030476868152618,
-0.007468545343726873,
0.031137458980083466,
-0.024329794570803642,
-0.0226571224629879,
-0.038670338690280914,
0.04444866254925728,
-0.004670034162700176,
-0.03548875078558922,
0.007100089453160763,
-0.004804549738764763,
-0.005573628470301628,
0.016446005553007126,
0.02325366996228695,
-0.028681086376309395,
-0.0015191501006484032,
0.02898520790040493,
0.040939558297395706,
-0.022002087906003,
0.0009862047154456377,
-0.003944818861782551,
0.002102538710460067,
-0.024563735350966454,
-0.01860995404422283,
0.0006967035587877035,
0.022785788401961327,
0.011767199262976646,
-0.019709473475813866,
0.04503351449966431,
-0.011176499538123608,
0.04105652868747711,
-0.003047072794288397,
0.034763533622026443,
0.0007306979969143867,
-0.006404116749763489,
-0.0125508988276124,
-0.0038307730574160814,
0.00990737322717905,
-0.013182537630200386,
-0.004722670651972294,
-0.011492319405078888,
0.028283387422561646,
0.0073281810618937016,
-0.0007654235232621431,
-0.021978694945573807,
0.012223382480442524,
-0.018914075568318367,
0.012632777914404869,
0.050905417650938034,
-0.01589624583721161,
-0.030716367065906525,
0.06007587909698486,
0.019510624930262566,
0.0019460911862552166,
-0.006333934608846903,
-0.00412904703989625,
-0.0019548640120774508,
0.019744563847780228,
-0.01714782603085041,
0.011808138340711594,
0.04129046946763992,
-0.003848318476229906,
-0.0017413933528587222,
0.021183297038078308,
-0.0034681654069572687,
-0.006252055522054434,
-0.027838900685310364,
0.00010600421228446066,
0.01498387847095728,
0.021557603031396866,
-0.033757589757442474,
0.012106412090361118,
0.0014694377314299345,
0.011199893429875374,
0.020165657624602318,
0.024750888347625732,
0.0063163889572024345,
0.004977080505341291,
0.006860300432890654,
0.014515997841954231,
0.018329225480556488,
-0.022785788401961327,
-0.005807568784803152,
-0.008889732882380486,
-0.05754932388663292,
-0.0473027378320694,
-0.01408320851624012,
-0.021510813385248184,
0.0047255950048565865,
0.0019972657319158316,
-0.011895866133272648,
0.00939270481467247,
-0.012316958978772163,
0.003649469232186675,
-0.006795966997742653,
-0.022411484271287918,
-0.013311205431818962,
-0.02263372763991356,
-0.019346866756677628,
-0.00795397162437439,
0.01225847378373146,
-0.02141723781824112,
0.025967378169298172,
0.016446005553007126,
0.0037342726718634367,
-0.009866434149444103,
0.021358752623200417,
-0.007655697409063578,
-0.03488050401210785,
-0.009778706356883049,
-0.04079919680953026,
0.018902380019426346,
-0.02327706292271614,
0.006006418261677027,
0.0006714818882755935,
-0.03738366439938545,
-0.007339878007769585,
-0.004974156618118286,
0.01901935040950775,
-0.0022575242910534143,
0.020563356578350067,
0.001881757634691894,
-0.010018494911491871,
-0.002927178516983986,
0.013568539172410965,
-0.012235079891979694,
-0.03958270698785782,
0.007035755552351475,
-0.008141123689711094,
0.015498547814786434,
-0.0033482711296528578,
-0.02084408327937126,
-0.04470599815249443,
0.015440062619745731,
-0.0032576192170381546,
0.005468355491757393,
-0.014176784083247185,
0.010503921657800674,
0.008796156384050846,
-0.029453089460730553,
0.04589909315109253,
0.02835356816649437,
0.0012274556793272495,
-0.017837950959801674,
-0.020282628014683723,
0.0018861439311876893,
0.022551849484443665,
0.04517387971282005,
0.012749748304486275,
0.04168816655874252,
-0.008410154841840267,
0.0038512428291141987,
-0.02245827205479145,
-0.00551221938803792,
-0.04884674400091171,
-0.01921819895505905,
0.015135940164327621,
0.024844463914632797,
-0.03834282234311104,
-0.004930292721837759,
-0.004281108267605305,
0.040073979645967484,
-0.007918880321085453,
0.00827563926577568,
-0.018645044416189194,
-0.008503731340169907,
0.011574198491871357,
-0.019943414255976677,
0.004161213990300894,
0.017264796420931816,
0.023347245529294014,
0.004310350865125656,
0.02861090376973152,
-0.034014925360679626,
0.04063543677330017,
-0.0022078119218349457,
0.017299888655543327,
-0.03511444479227066,
0.0032663920428603888,
0.0035149536561220884,
-0.001807189080864191,
-0.006825209595263004,
0.014562785625457764,
0.0371263325214386,
-0.02732423134148121,
-0.02779211290180683,
0.03960609808564186,
-0.008234700188040733,
-0.017042553052306175,
-0.03857676312327385,
-0.003953591920435429,
0.006807663943618536,
-0.015592123381793499,
-0.006521087139844894,
0.020036989822983742,
-0.006269601173698902,
-0.024376582354307175,
-0.03038885071873665,
0.018808802589774132,
0.024329794570803642,
-0.004243093077093363,
-0.012094715610146523,
0.004880580119788647,
0.005228566471487284,
-0.04391060024499893,
-0.10293374955654144,
0.033968135714530945,
0.010878225788474083,
-0.004415623843669891,
0.0020118867978453636,
-0.007585515268146992,
0.013673813082277775,
0.02737101912498474,
-0.07359763234853745,
0.018481286242604256,
0.03852997347712517,
0.023218577727675438,
0.008152821101248264,
-0.007176119834184647,
0.013369690626859665,
0.0019080758793279529,
0.013697206974029541,
0.008117729797959328,
-0.019861534237861633,
0.0027341777458786964,
0.039489127695560455,
-0.01734667643904686,
0.017896436154842377,
0.041734956204891205,
0.02716047316789627,
-0.0064684501849114895,
-0.024563735350966454,
-0.023756641894578934,
0.0424133837223053,
-0.03925519064068794,
-0.013217628933489323,
-0.03286861628293991,
-0.008819551207125187,
-0.010965953581035137,
0.020984448492527008,
0.020902568474411964,
-0.007579667028039694,
0.021545905619859695,
-0.007369120605289936,
0.024236219003796577,
-0.02631828747689724,
-0.008854641579091549,
0.025476103648543358,
0.013907752931118011,
-0.003766439389437437,
-0.003848318476229906,
-0.0015293849864974618,
-0.017288191244006157,
-0.012469019740819931,
0.008725974708795547,
-0.010848983190953732,
-0.0010059433989226818,
0.02083238773047924,
0.01696067489683628,
-0.02449355274438858,
0.00729893846437335,
0.010691073723137379,
0.027862293645739555,
-0.03272825479507446,
-0.0030733912717550993,
-0.01346326619386673,
0.002251675818115473,
-0.008568065240979195,
-0.00926988571882248,
0.005655507557094097,
-0.027066897600889206,
-0.0011448455043137074,
-0.02592059038579464,
0.025195375084877014,
-0.0029754287097603083,
0.00433082040399313,
-0.001881757634691894,
-0.0035061808302998543,
0.0029842015355825424,
0.008766913786530495,
-0.011960200034081936,
0.028213204815983772,
-0.05455488711595535,
0.005140839144587517,
-0.03609699383378029,
-0.020715417340397835,
-0.011340257711708546,
-0.01203623041510582,
-0.030365455895662308,
0.010691073723137379,
0.001198944286443293,
-0.006521087139844894,
0.01398963201791048,
0.017873041331768036,
-0.010264132171869278,
0.00020798758487217128,
-0.021300267428159714,
0.006714087910950184,
0.013498357497155666,
0.033780984580516815,
-0.03043563850224018,
-0.006392419803887606,
-0.019674383103847504,
-0.030880125239491463,
-0.01315914373844862,
-0.03244752436876297,
-0.0424133837223053,
0.007293090224266052,
-0.028447145596146584,
-0.0021259328350424767,
-0.00033647200325503945,
-0.0050589595921337605,
-0.0005212483229115605,
0.030365455895662308,
-0.02549949660897255,
-0.000026798048565979116,
-0.010965953581035137,
0.01060919463634491,
0.0261545293033123,
0.029055390506982803,
-0.014749938622117043,
0.011229136027395725,
0.02347591333091259,
0.02673938125371933,
0.0023233199026435614,
0.012118109501898289,
0.028681086376309395,
-0.011697016656398773,
-0.0027093214448541403,
0.02324197255074978,
0.019674383103847504,
-0.05722180753946304,
0.01203623041510582,
0.005588249769061804,
-0.01091331709176302,
0.025265555828809738,
-0.0367286317050457,
0.022984638810157776,
-0.003579287091270089,
0.01815376989543438,
0.03247091919183731,
0.02449355274438858,
-0.059327270835638046,
0.0054069459438323975,
-0.00907688494771719,
-0.003286861814558506,
-0.023019729182124138,
0.0012508498039096594,
-0.020165657624602318,
0.015814367681741714,
0.005117444787174463,
0.007369120605289936,
0.03130121901631355,
0.014024723321199417,
0.003263467689976096,
-0.0030763153918087482,
0.0018408180912956595,
0.009351764805614948,
0.032377343624830246,
-0.030763154849410057,
-0.005184702575206757,
0.03815566748380661,
-0.005146687384694815,
0.014445816166698933,
0.03062278963625431,
-0.004716821946203709,
-0.019112925976514816,
-0.0075621213763952255,
-0.016855401918292046,
0.021592693403363228,
-0.01133440900593996,
-0.004333744756877422,
0.11219778656959534,
-0.047022007405757904,
-0.02266881801187992,
0.0045735337771475315,
0.0035646657925099134,
-0.015615517273545265,
0.037687789648771286,
0.01182568445801735,
0.014761635102331638,
-0.028259992599487305,
0.03197964280843735,
0.00298127718269825,
0.02650544047355652,
0.0020937661174684763,
0.04912747070193291,
-0.012527504935860634,
0.02324197255074978,
0.021990392357110977,
0.009457037784159184,
-0.01315914373844862,
-0.03200303763151169,
0.0005015095812268555,
-0.009755312465131283,
0.04533763602375984,
-0.03881070390343666,
-0.02528895065188408,
0.0005117444670759141,
-0.02140554040670395,
-0.015802670270204544,
-0.005696447100490332,
0.007339878007769585,
0.015615517273545265,
0.02613113634288311,
-0.010691073723137379,
0.003792757634073496,
-0.05899975448846817,
0.0011601978912949562,
-0.002134705660864711,
0.017416859045624733,
-0.03291540592908859,
0.008310730569064617,
0.00606490345671773,
-0.0050911265425384045,
-0.005240263417363167,
0.018691832199692726,
0.0013056795578449965,
-0.02634168229997158,
0.0021595617290586233,
-0.00031399179715663195,
-0.05076505243778229,
0.0020425915718078613,
-0.0039038793183863163,
0.006743330042809248,
-0.009451190009713173,
-0.04388720914721489,
0.00041195430094376206,
0.017218008637428284,
-0.016878794878721237,
-0.007462696637958288,
-0.023008031770586967,
-0.013404780998826027,
0.012749748304486275,
0.022177543491125107,
0.01062673982232809,
0.01959250308573246
] | 2025-01-08 | 169 | 39769449 | [
"different non-viral gene transfer methods",
"gene transfer",
"high gene transfer rates",
"CAR",
"CAR-T cell manufacturing",
"genomic integration methods",
"CAR-T cell production",
"targeted integration",
"registered CAR-T cell clinical trials",
"CAR-T cells",
"potential malignant transformation",
"stable but non-targeted gene integration",
"viral vectors",
"Non-integrating CAR-encoding vectors",
"Transposon-based gene transfer methods",
"high transfection efficiencies",
"next-generation CAR-T cell therapy",
"CAR-T cell products",
"cancer therapy",
"hematologic malignancies",
"constant drivers",
"integration-mediated malignant transformation",
"applications",
"only transient CAR expression",
"alternatives",
"increasing numbers",
"Programmable endonucleases",
"use",
"costly and time-consuming vector manufacturing",
"efforts"
] | [
"CAR-T cells",
"CRISPR",
"gene transfer",
"non-integrating",
"non-viral",
"piggybac",
"programmable endonuclease",
"sleeping beauty",
"transient",
"transposase"
] | 0 | 10.3390/ijms252413685
10.1053/j.seminhematol.2020.07.005
10.1038/s41434-021-00254-w
10.1200/EDBK_397912
10.1038/mt.2016.11
10.1186/s12967-022-03729-5
10.1126/science.1088547
10.1038/s41586-018-0178-z
10.3390/ijms25137333
10.1038/s41578-024-00725-7
10.1016/j.gendis.2017.04.001
10.1093/nar/gks643
10.1038/mt.2010.47
10.1038/s41591-018-0204-6
10.1038/s41586-022-05140-y
10.1038/sj.gt.3302213
10.1093/nar/27.2.426
10.1038/35057062
10.1016/0168-9525(89)90039-5
10.1038/nrg2165
10.1093/nar/gkv017
10.1038/leu.2016.180
10.1016/j.omtn.2017.12.017
10.1101/675009
10.1038/sj.mt.6300160
10.1089/hum.2009.138
10.1002/dvg.20508
10.3390/bioengineering8020016
10.3390/v13010076
10.1128/microbiolspec.MDNA3-0042-2014
10.1038/s41587-019-0291-z
10.1016/S0092-8674(00)80436-5
10.1016/S1525-0016(03)00099-6
10.1038/ng.343
10.1016/S0022-2836(02)00237-1
10.1074/jbc.M204001200
10.1128/MCB.24.20.9239-9247.2004
10.1038/sj.mt.6300404
10.1158/0008-5472.CAN-07-5600
10.1136/jitc-2022-005189
10.1016/j.ymthe.2024.05.022
10.1016/j.ymthe.2020.05.021
10.1089/hum.2011.167
10.1172/JCI86721
10.3389/fimmu.2022.1032397
10.1089/hum.2017.207
10.3390/cells9061337
10.1172/JCI138473
10.1016/j.ymthe.2018.01.012
10.1186/1472-6750-8-60
10.1016/j.ymthe.2022.06.006
10.3389/fimmu.2023.1270843
10.1128/jvi.47.2.287-300.1983
10.1007/s00438-003-0909-0
10.1038/mt.2010.141
10.1089/hum.2009.114
10.1038/mt.2011.131
10.1182/blood-2021-149089
10.1007/s00432-021-03613-7
10.1096/fj.202201654R
10.1073/pnas.1008322108
10.1093/nar/gkm446
10.1182/blood.2021010858
10.1182/blood.2021010813
10.1038/gt.2014.104
10.1038/383030a0
10.1016/j.ymthe.2024.04.024
10.1534/genetics.111.126813
10.1186/s13100-016-0062-z
10.1534/genetics.106.060244
10.1186/1471-2164-10-477
10.1186/1471-2164-10-418
10.1093/nar/gks1035
10.1371/journal.pone.0042666
10.3791/59202-v
10.1038/s41589-023-01279-5
10.1126/science.aba8853
10.1038/s41586-018-0326-5
10.1016/j.cell.2015.09.038
10.1038/s41467-022-30465-7
10.1186/s13059-023-02928-7
10.1101/gr.089417.108
10.1126/science.1178817
10.1038/nbt.2517
10.1038/s41467-022-30896-2
10.1016/j.ymthe.2024.08.018
10.1038/s41580-019-0152-0
10.1074/jbc.M116.752329
10.1146/annurev.biochem.77.061306.125255
10.1038/s41556-019-0425-z
10.1038/ncomms10431
10.1038/s41421-023-00552-0
10.1038/s41467-024-46479-2
10.1371/journal.pgen.1004086
10.1186/s12943-023-01799-7
10.1038/nm.4313
10.1038/s41467-023-39632-w
10.1093/nar/gkad255
10.1016/j.omtm.2022.03.018
10.1038/s41586-021-04274-9
10.1038/s41467-023-40344-4
10.1016/j.crmeth.2021.100154
10.1182/blood-2012-01-405365
10.3390/v15010202
10.1182/bloodadvances.2021006232
10.1038/nature21405
10.1182/blood.2023020973
10.1038/s41591-021-01621-1
10.1038/s41467-022-28244-5
10.1038/nbt.3117
10.1038/nmeth.4278
10.1016/j.stem.2021.02.002
10.3389/fgeed.2023.1130736
10.21203/rs.3.rs-4577114/v1
10.1016/j.tibtech.2018.06.005
10.1038/d41586-023-03317-7
10.1371/journal.pgen.1004250
10.3389/fimmu.2022.867013
10.1126/sciadv.abf1333
10.1038/gt.2010.149
10.1016/j.omtn.2023.04.003
10.1038/sj.mt.6300281
10.1016/0092-8674(84)90208-3
10.1038/mtna.2013.40
10.15252/emmm.201505869
10.1016/j.omtm.2020.04.017
10.1186/s12929-023-00977-5
10.1586/14760584.2015.1000871
10.1038/nrd.2017.243
10.1089/hum.2018.145
10.1016/j.ymthe.2018.12.011
10.1016/j.cels.2021.12.002
10.1261/rna.056614.116
10.1016/j.bbrc.2005.03.067
10.1182/blood-2006-04-015024
10.1038/s41580-021-00417-y
10.1016/j.tibtech.2004.04.006
10.1038/s41586-023-06127-z
10.1016/j.immuni.2005.06.008
10.1038/mt.2008.200
10.1158/2326-6066.CIR-13-0170
10.1158/2767-9764.CRC-22-0486
10.1182/blood.V130.Suppl_1.1359.1359
10.1182/blood-2018-03-837609
10.1158/2326-6066.CIR-13-0006
10.1016/j.ymthe.2019.01.018
10.1038/s41576-021-00439-4
10.1073/pnas.2315789121
10.1038/s41591-023-02612-0
10.1038/s41587-022-01393-0
10.1038/s41587-022-01491-z
10.1038/s41591-022-02061-1
10.1073/pnas.86.24.10024
10.1016/0006-291X(87)90502-X
10.1158/1078-0432.CCR-24-1798
10.1038/s41591-023-02767-w
10.1172/JCI35700
10.2174/156652311797415890
10.1371/journal.pone.0075344
10.1002/hep.27842
10.1016/j.ymthe.2024.09.002
10.1016/j.omtm.2018.02.004
10.1038/s41576-022-00541-1
10.1038/s41587-023-01915-4
10.1038/s41375-023-02039-z
10.1016/j.ymthe.2019.01.014
10.3390/ijms25105361
10.1038/s41565-020-0669-6
10.1038/s41571-023-00811-9 | [
"Gehrke",
"Gonçalves",
"Andrae",
"Rasko",
"Ho",
"Einsele",
"Hudecek",
"Friedel"
] | [
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany.\nFraunhofer-Institut für Zelltherapie und Immunologie, Außenstelle Zelluläre Immuntherapie, 97070 Würzburg, Germany.",
"Medizinische Klinik und Poliklinik II und Lehrstuhl für Zelluläre Immuntherapie, Universitätsklinikum Würzburg, 97080 Würzburg, Germany."
] | [
"39769449",
"32892841",
"33846552",
"37433102",
"26755332",
"36348415",
"14564000",
"29849141",
"39000440",
"28944281",
"22753106",
"20372108",
"30374197",
"36045296",
"14724672",
"9862961",
"11237011",
"2543105",
"17984973",
"25605795",
"27491640",
"29858090",
"17440442",
"20528476",
"19391106",
"33498466",
"33429848",
"26104705",
"31685959",
"9390559",
"12842434",
"19412179",
"12083513",
"12082109",
"15456893",
"18227839",
"18413766",
"36096530",
"38751112",
"32526203",
"22107246",
"27482888",
"36439104",
"29641322",
"32471151",
"32780725",
"29503198",
"18691430",
"35711141",
"37795087",
"16789244",
"12955498",
"20606646",
"19905893",
"21772253",
"34032893",
"37534940",
"21205896",
"17576687",
"33974080",
"34010392",
"25427612",
"8779712",
"38627969",
"21368277",
"27042235",
"16959904",
"19832998",
"19737393",
"23143102",
"23166581",
"30882797",
"36894722",
"32217751",
"29995861",
"26422227",
"35595757",
"37095570",
"19470664",
"19933106",
"23417094",
"35773273",
"39169622",
"31263220",
"27703001",
"18275380",
"31792376",
"26786405",
"37402729",
"38521791",
"24453986",
"37365642",
"28388605",
"37429857",
"37070192",
"35573047",
"34987222",
"37580318",
"35474867",
"22535661",
"36680242",
"35008103",
"28225754",
"38493479",
"35027758",
"35110541",
"25513782",
"28459458",
"33626327",
"36890979",
"30017092",
"37903930",
"24721906",
"35757746",
"33853779",
"21107439",
"24715283",
"37346980",
"17700544",
"6091913",
"23941867",
"27189167",
"32420409",
"23296935",
"37805495",
"25586101",
"29326426",
"30024272",
"30638957",
"35041803",
"8548660",
"11680853",
"27368341",
"15809089",
"16940422",
"34594027",
"15245907",
"37130545",
"16111635",
"18797453",
"24579088",
"37377890",
"29925499",
"24777247",
"30819612",
"34983972",
"38437565",
"37872225",
"35851375",
"36329321",
"36357682",
"2513569",
"3122749",
"39256908",
"38195751",
"18688285",
"21888620",
"24124483",
"26011400",
"39326408",
"29766024",
"38379101",
"36344749",
"37679541",
"37798328",
"30803822",
"38791398",
"32251383",
"37587254"
] | [] | 9.076534 | 2.917784 |
39769267 | 63 | Genetically Engineered T Cells and Recombinant Antibodies to Target Intracellular Neoantigens: Current Status and Future Directions. | Recombinant antibodies and, more recently, T cell receptor (TCR)-engineered T cell therapies represent two immunological strategies that have come to the forefront of clinical interest for targeting intracellular neoantigens in benign and malignant diseases. T cell-based therapies targeting neoantigens use T cells expressing a recombinant complete TCR (TCR-T cell), a chimeric antigen receptor (CAR) with the variable domains of a neoepitope-reactive TCR as a binding domain (TCR-CAR-T cell) or a TCR-like antibody as a binding domain (TCR-like CAR-T cell). Furthermore, the synthetic T cell receptor and antigen receptor (STAR) and heterodimeric TCR-like CAR (T-CAR) are designed as a double-chain TCRαβ-based receptor with variable regions of immunoglobulin heavy and light chains (VH and VL) fused to TCR-Cα and TCR-Cβ, respectively, resulting in TCR signaling. In contrast to the use of recombinant T cells, anti-neopeptide MHC (pMHC) antibodies and intrabodies neutralizing intracellular neoantigens can be more easily applied to cancer patients. However, different limitations should be considered, such as the loss of neoantigens, the modification of antigen peptide presentation, tumor heterogenicity, and the immunosuppressive activity of the tumor environment. The simultaneous application of immune checkpoint blocking antibodies and of CRISPR/Cas9-based genome editing tools to engineer different recombinant T cells with enhanced therapeutic functions could make T cell therapies more efficient and could pave the way for its routine clinical application. | [
0.01663902960717678,
0.010378068313002586,
0.05691162124276161,
0.044423818588256836,
-0.024611659348011017,
-0.0014486645814031363,
0.01997138373553753,
0.032777637243270874,
0.0009041714365594089,
0.01182815432548523,
-0.0050753019750118256,
-0.03709946200251579,
-0.0055529773235321045,
0.021074587479233742,
-0.004247899632900953,
-0.07679201662540436,
0.042444877326488495,
-0.025544265285134315,
0.007608687970787287,
0.017401035875082016,
0.03848699480295181,
0.031208131462335587,
-0.014842059463262558,
-0.018754448741674423,
-0.016240965574979782,
-0.0008608109783381224,
0.028978979215025902,
0.024975603446364403,
-0.015740543603897095,
-0.04440107196569443,
0.02950214594602585,
-0.031117144972085953,
-0.016354698687791824,
-0.018276773393154144,
0.004463991150259972,
0.025271307677030563,
0.004637432750314474,
-0.007312983740121126,
-0.01626371219754219,
0.021074587479233742,
0.037986572831869125,
0.00015584872744511813,
0.010014125145971775,
0.06778442114591599,
-0.07533624768257141,
0.0029940016102045774,
-0.02365630865097046,
-0.043377481400966644,
-0.004842150956392288,
-0.004734104964882135,
0.008063617162406445,
-0.023610815405845642,
-0.058412887156009674,
0.03603037819266319,
-0.07201526314020157,
0.022155042737722397,
-0.07683750987052917,
0.010975162498652935,
-0.008183035999536514,
0.02932017482817173,
0.02112007886171341,
-0.009775287471711636,
0.017207689583301544,
-0.0023770041298121214,
-0.046584732830524445,
0.03223172202706337,
-0.0174920205026865,
-0.001129503478296101,
-0.017184942960739136,
0.0006603578804060817,
0.01588839665055275,
-0.03054848313331604,
-0.004714202135801315,
0.03175404667854309,
0.04023846983909607,
-0.002187924226745963,
-0.00273383897729218,
0.04517444968223572,
0.014034559950232506,
-0.018913673236966133,
0.04804050549864769,
-0.008490112610161304,
-0.00030103506287559867,
-0.03382397070527077,
-0.034483619034290314,
0.002347149420529604,
0.0023926421999931335,
-0.002615841804072261,
-0.06528231501579285,
0.006863741669803858,
-0.0039038595277816057,
0.011242433451116085,
-0.023212753236293793,
0.038919176906347275,
-0.022371133789420128,
0.006442932412028313,
-0.061187952756881714,
-0.03841875493526459,
0.02454342134296894,
0.02934292145073414,
0.03680375590920448,
-0.004284862894564867,
-0.03220897540450096,
0.0019888929091393948,
0.04999670013785362,
-0.04822247475385666,
-0.01350001897662878,
0.0007712468504905701,
0.04958726465702057,
0.0038697400595992804,
0.06796639412641525,
-0.0064088124781847,
0.0002717134775593877,
0.03357376158237457,
-0.03744065761566162,
-0.052726272493600845,
-0.038737207651138306,
0.0026343234349042177,
0.0026513831689953804,
0.04415086284279823,
0.023701801896095276,
0.027568697929382324,
0.046766702085733414,
-0.04415086284279823,
-0.011094581335783005,
-0.03664453327655792,
0.0801130011677742,
-0.025680743157863617,
-0.054409511387348175,
-0.03407418355345726,
0.04035220295190811,
0.01197600644081831,
0.007108265999704599,
0.007091206032782793,
-0.07406244426965714,
0.0008274021674878895,
0.02363356202840805,
0.007187878713011742,
-0.026317643001675606,
-0.0003214713360648602,
0.025112081319093704,
-0.029206443578004837,
0.0005199696752242744,
0.011049088090658188,
-0.03007080778479576,
-0.03421066328883171,
-0.006494111847132444,
0.02392926625907421,
0.0133521668612957,
0.026317643001675606,
-0.02779616229236126,
0.04958726465702057,
0.04881388321518898,
0.003070770762860775,
-0.03680375590920448,
-0.04835895448923111,
-0.010247276164591312,
0.07947610318660736,
-0.008996221236884594,
-0.06710202991962433,
-0.048131488263607025,
0.02254173345863819,
-0.007148072123527527,
0.005982316564768553,
0.028956232592463493,
-0.007574568036943674,
-0.010406501591205597,
0.0347110852599144,
-0.05077007785439491,
-0.003144696820527315,
-0.028751514852046967,
-0.02048317901790142,
-0.08907510340213776,
0.02422497048974037,
-0.04424184560775757,
0.0016917672473937273,
0.0156268123537302,
0.03036651201546192,
-0.03052573651075363,
-0.01029276940971613,
-0.00783615279942751,
-0.005157757550477982,
-0.017764978110790253,
0.0035456030163913965,
0.006994533818215132,
-0.004927449859678745,
-0.005743478890508413,
0.018686208873987198,
-0.04954177141189575,
-0.020926734432578087,
-0.02440694160759449,
0.03318707272410393,
0.034984041005373,
-0.015581319108605385,
0.011657556518912315,
-0.016536669805645943,
0.04483325406908989,
0.019823532551527023,
-0.007210624869912863,
-0.05509190261363983,
0.05723007023334503,
-0.02809186652302742,
-0.019618814811110497,
-0.0024011721834540367,
-0.003858366748318076,
-0.021085960790514946,
0.009957258589565754,
0.020710643380880356,
-0.0035882527008652687,
0.03841875493526459,
0.03025277890264988,
-0.0268408115953207,
-0.0084787392988801,
0.01824265345931053,
-0.03744065761566162,
-0.03719044849276543,
-0.020176101475954056,
0.020073743537068367,
0.00416544359177351,
0.020232968032360077,
-0.03113989159464836,
0.01096378918737173,
-0.01663902960717678,
0.005874271038919687,
-0.04253586381673813,
0.013556884601712227,
-0.02900172583758831,
-0.025726236402988434,
-0.005098048131912947,
-0.017878711223602295,
-0.03157207369804382,
-0.008131856098771095,
0.037531644105911255,
-0.02654510736465454,
-0.004717045463621616,
0.011094581335783005,
0.008546979166567326,
-0.025112081319093704,
0.03821403905749321,
-0.04017023369669914,
0.016309205442667007,
0.01794694922864437,
0.0148875517770648,
-0.03052573651075363,
-0.04435557872056961,
0.004415654577314854,
0.00787595845758915,
-0.06869427859783173,
0.02841031737625599,
-0.005058242008090019,
0.00395219586789608,
0.02363356202840805,
0.030002567917108536,
0.007665554061532021,
0.039965514093637466,
0.032004255801439285,
0.013386286795139313,
-0.012476428411900997,
0.0006290815072134137,
0.0022177789360284805,
0.01397769432514906,
0.03025277890264988,
-0.003164599882438779,
-0.004859210457652807,
-0.05049712210893631,
0.005717888940125704,
-0.002907280810177326,
0.019288990646600723,
0.04055692255496979,
-0.0178900845348835,
0.02993432991206646,
0.0013136075576767325,
0.0016533826710656285,
-0.027659684419631958,
-0.04524268954992294,
-0.026454122737050056,
-0.01105477474629879,
0.017139451578259468,
0.01935723051428795,
0.025703489780426025,
-0.01887955516576767,
-0.010759071446955204,
-0.010196096263825893,
-0.03512052074074745,
-0.008365007117390633,
-0.009087206795811653,
0.0036707085091620684,
-0.02066515013575554,
-0.010980849154293537,
-0.05031514912843704,
0.029047217220067978,
-0.012590160593390465,
-0.04096635803580284,
-0.04003375396132469,
-0.006346259731799364,
0.0032498992513865232,
-0.02101772092282772,
-0.02531679905951023,
-0.053954582661390305,
0.009763914160430431,
-0.04667571559548378,
-0.00879719015210867,
0.015251494944095612,
-0.040465936064720154,
-0.015319734811782837,
0.015319734811782837,
0.0006091783870942891,
-0.03371024131774902,
0.06014161556959152,
0.02333785779774189,
0.02672708034515381,
-0.03516601398587227,
0.03073045425117016,
-0.013465899042785168,
0.01296547707170248,
0.0050724586471915245,
0.018788568675518036,
-0.061005979776382446,
0.0073300437070429325,
-0.03380122780799866,
-0.04067065566778183,
-0.01666177436709404,
-0.02656785398721695,
0.014364384114742279,
0.008763070218265057,
-0.025976447388529778,
0.006266647018492222,
-0.01197600644081831,
0.03025277890264988,
-0.03912389650940895,
0.02929742820560932,
-0.012863118201494217,
0.0678299143910408,
0.0011152869556099176,
-0.0012951260432600975,
-0.01045199390500784,
-0.017560260370373726,
-0.01709395833313465,
-0.007142385467886925,
0.011953259818255901,
-0.021938951686024666,
0.026499615982174873,
-0.045492902398109436,
0.02278057113289833,
0.02531679905951023,
-0.02779616229236126,
0.007773599587380886,
0.008694831281900406,
-0.010315515100955963,
0.009496643207967281,
-0.001602203119546175,
0.019152510911226273,
0.008825622498989105,
-0.022064058110117912,
0.014478116296231747,
0.04667571559548378,
0.004202406853437424,
-0.011515391059219837,
0.01158931665122509,
-0.018174413591623306,
0.013386286795139313,
-0.023861026391386986,
-0.01632057875394821,
0.024475181475281715,
0.033096086233854294,
0.04844994097948074,
-0.013374913483858109,
0.03327805921435356,
-0.0014998441329225898,
-0.022041311487555504,
-0.024293210357427597,
-0.005709358956664801,
0.03330080583691597,
0.00648273853585124,
-0.02745496667921543,
0.04453755170106888,
0.017662618309259415,
0.023428844287991524,
0.040784385055303574,
0.007534761913120747,
0.04663022607564926,
-0.03621235117316246,
-0.005993689876049757,
-0.021404409781098366,
-0.011657556518912315,
0.016172725707292557,
0.03534798324108124,
-0.040443189442157745,
-0.07588215917348862,
0.05077007785439491,
0.015604065731167793,
-0.032618410885334015,
-0.012772132642567158,
0.00556719396263361,
-0.026522362604737282,
0.04808599874377251,
-0.052407823503017426,
0.07338005304336548,
0.047631070017814636,
0.013136075809597969,
0.008313828147947788,
-0.02518032118678093,
-0.021290678530931473,
-0.07301610708236694,
-0.006698829587548971,
-0.018174413591623306,
0.03350552171468735,
0.03241369128227234,
0.029047217220067978,
-0.013920827768743038,
-0.002979784971103072,
0.0400565005838871,
0.014898925088346004,
0.05864034965634346,
0.004245056305080652,
-0.015820156782865524,
-0.046129804104566574,
0.031208131462335587,
0.0011494065402075648,
0.006147228181362152,
0.028455810621380806,
-0.05882232263684273,
0.025726236402988434,
-0.04524268954992294,
0.02000550366938114,
-0.0052060941234230995,
0.009650181978940964,
0.02472539246082306,
0.0003678527718875557,
-0.026590600609779358,
0.0010975162731483579,
0.049359798431396484,
-0.04562938213348389,
-0.03773636370897293,
-0.013249807991087437,
0.05390908941626549,
-0.0027068275958299637,
0.02868327498435974,
-0.02947940118610859,
0.0435367077589035,
-0.046425506472587585,
0.004850680474191904,
-0.02349708415567875,
0.0005842994432896376,
0.01101496908813715,
0.02266683802008629,
-0.025089334696531296,
0.0018865338061004877,
-0.019368603825569153,
-0.018015189096331596,
-0.013579631224274635,
-0.013295300304889679,
0.02347433753311634,
0.003824247047305107,
-0.00939997099339962,
-0.028455810621380806,
0.05850386992096901,
-0.06077851727604866,
0.007176505401730537,
0.03625784441828728,
0.018811315298080444,
-0.05359063670039177,
-0.01935723051428795,
-0.025271307677030563,
-0.003232839284464717,
0.037827346473932266,
0.03527974709868431,
-0.02411123737692833,
0.007318670395761728,
-0.057321056723594666,
0.018970539793372154,
-0.016275085508823395,
0.013363540172576904,
-0.00144511042162776,
-0.016377445310354233,
0.013943574391305447,
0.02422497048974037,
0.01725318282842636,
0.012169350869953632,
0.027363980188965797,
-0.008245588280260563,
0.005746322218328714,
-0.0016349011566489935,
-0.02131342515349388,
-0.0022803316824138165,
0.0001471411087550223,
-0.013124702498316765,
0.015683677047491074,
0.006414499133825302,
0.04374142363667488,
0.035666435956954956,
-0.020062370225787163,
0.029433907940983772,
-0.009217998944222927,
0.0071310121566057205,
-0.03241369128227234,
-0.001651961007155478,
-0.03962431848049164,
-0.05477345362305641,
-0.006459991913288832,
-0.014171038754284382,
0.008473052643239498,
-0.026818064972758293,
0.03436988592147827,
0.04317276552319527,
0.038441501557826996,
0.07274314761161804,
0.06619217246770859,
-0.03334629535675049,
0.05959570035338402,
-0.037053968757390976,
-0.03052573651075363,
0.005732105579227209,
-0.02688630484044552,
-0.010941042564809322,
-0.028978979215025902,
-0.05081557109951973,
-0.01778772473335266,
0.0018367759184911847,
-0.014751072973012924,
0.02611292526125908,
-0.005695142783224583,
-0.009172506630420685,
0.033391788601875305,
0.02668158710002899,
-0.034301649779081345,
-0.046584732830524445,
-0.012897237204015255,
-0.038464248180389404,
-0.0558197908103466,
0.00387826981022954,
-0.01890229992568493,
0.01925487071275711,
0.032163482159376144,
-0.0237700417637825,
-0.008700517937541008,
-0.032299961894750595,
0.04001100733876228,
-0.031526580452919006,
-0.013852588832378387,
0.024179477244615555,
-0.014398503117263317,
0.03434713929891586,
-0.016695894300937653,
0.007733793463557959,
0.030025314539670944,
-0.013534137979149818,
-0.01644568331539631,
0.018834061920642853,
0.013750229962170124,
0.030775947496294975,
-0.029206443578004837,
0.009109953418374062,
-0.027978135272860527,
-0.008620904758572578,
-0.026294896379113197,
-0.008620904758572578,
-0.04262685030698776,
-0.0018154510762542486,
-0.01428477093577385,
-0.03411967679858208,
-0.026931798085570335,
-0.0013676303206011653,
-0.023428844287991524,
0.016946105286478996,
0.0244296882301569,
0.005439245142042637,
-0.008063617162406445,
-0.04999670013785362,
0.019402721896767616,
-0.010787504725158215,
-0.022985288873314857,
0.0041227941401302814,
0.004864897113293409,
0.01434163749217987,
0.024202223867177963,
-0.011873647570610046,
0.0043275123462080956,
-0.01650254987180233,
0.018367759883403778,
-0.0371222086250782,
-0.012772132642567158,
0.0031191071029752493,
0.04108009114861488,
0.00652823131531477,
0.00474547827616334,
-0.051043037325143814,
-0.01305646263062954,
-0.0039095464162528515,
0.0036536487750709057,
0.022337015718221664,
-0.004102891311049461,
0.022280149161815643,
0.01933448389172554,
-0.04426459223031998,
0.01158931665122509,
0.011987379752099514,
-0.004620372783392668,
-0.006966100540012121,
0.00679550226777792,
0.02411123737692833,
-0.006545291282236576,
-0.02704552933573723,
-0.03164031356573105,
-0.03129911795258522,
0.01685512065887451,
0.00032467005075886846,
-0.009502329863607883,
-0.008973474614322186,
-0.009798034094274044,
0.01762850023806095,
0.016457056626677513,
-0.027568697929382324,
0.02638588286936283,
0.0046544927172362804,
0.01666177436709404,
-0.010980849154293537,
-0.011549510061740875,
0.005095204804092646,
-0.014739700593054295,
-0.021995818242430687,
-0.004771068226546049,
-0.004279176238924265,
0.025225814431905746,
0.019596068188548088,
-0.034620098769664764,
-0.03073045425117016,
0.004202406853437424,
-0.0020201692823320627,
-0.003935135900974274,
0.010343948379158974,
-0.03405143693089485,
0.0005345416138879955,
0.05222585052251816,
-0.016115861013531685,
-0.025043843314051628,
0.02806911990046501,
0.012453681789338589,
0.0027793319895863533,
0.01727592945098877,
-0.014478116296231747,
0.010281396098434925,
-0.002075613709166646,
-0.00874601025134325,
-0.006380379665642977,
0.020460432395339012,
-0.03609861806035042,
0.0020898301154375076,
0.02745496667921543,
-0.03270939737558365,
-0.0190956462174654,
-0.002094095107167959,
0.04556114226579666,
-0.024133983999490738,
0.01520600263029337,
-0.010275709442794323,
0.010730638168752193,
-0.009746854193508625,
0.04663022607564926,
0.04037494957447052,
-0.019698426127433777,
0.023008035495877266,
-0.007853211835026741,
0.011447151191532612,
-0.0030195913277566433,
0.001349148922599852,
0.01640019193291664,
0.010588472709059715,
-0.020449059084057808,
-0.01257878728210926,
0.059049785137176514,
0.01986902579665184,
0.03759988397359848,
0.01443262305110693,
-0.008001063950359821,
0.029229190200567245,
0.032004255801439285,
-0.02024434134364128,
-0.023224126547574997,
0.0029541952535510063,
-0.0064997985027730465,
0.0007197119412012398,
-0.00975822750478983,
-0.05222585052251816,
0.017583006992936134,
0.003955039195716381,
-0.029684118926525116,
0.019539201632142067,
0.007267490960657597,
0.011782662011682987,
0.026203911751508713,
-0.006306453607976437,
-0.03546171635389328,
-0.017150824889540672,
0.037372417747974396,
0.014637340791523457,
-0.008615218102931976,
-0.011413032189011574,
-0.013477272354066372,
-0.014057306572794914,
0.020062370225787163,
0.02331511303782463,
0.006852368358522654,
-0.032777637243270874,
0.017025718465447426,
-0.0030622410122305155,
-0.007898705080151558,
-0.009496643207967281,
0.014296144247055054,
0.044105369597673416,
-0.010008438490331173,
-0.013238434679806232,
0.008342260494828224,
-0.02913820371031761,
-0.030753200873732567,
-0.012942730449140072,
-0.004054554738104343,
0.04986022040247917,
0.00474547827616334,
-0.026340389624238014,
0.0021296364720910788,
0.006624903995543718,
-0.010781818069517612,
-0.0014842059463262558,
0.03102615848183632,
0.02331511303782463,
-0.020437685772776604,
0.059914153069257736,
-0.014227905310690403,
0.018163040280342102,
-0.03305059298872948,
-0.03025277890264988,
-0.039669811725616455,
-0.006255274172872305,
-0.03270939737558365,
0.000703007506672293,
-0.018140295520424843,
-0.04517444968223572,
0.0021154198329895735,
-0.018993286415934563,
0.030048061162233353,
-0.041512273252010345,
-0.046903181821107864,
-0.013409032486379147,
-0.010702204890549183,
0.04094361141324043,
0.03038925863802433,
-0.0021552261896431446,
0.024202223867177963,
-0.01895916648209095,
-0.004210936836898327,
0.006920607760548592,
-0.027204755693674088,
-0.02932017482817173,
0.004944509826600552,
-0.02622665837407112,
0.00783615279942751,
-0.014159665443003178,
-0.054136551916599274,
-0.0297751035541296,
-0.013511392287909985,
-0.0043929084204137325,
0.002075613709166646,
-0.008740323595702648,
-0.008927982300519943,
0.002078457036986947,
-0.0057719117030501366,
0.027227502316236496,
-0.02472539246082306,
0.0427178330719471,
-0.017821844667196274,
-0.01311332918703556,
-0.01419378537684679,
-0.017128078266978264,
-0.0008878224180079997,
-0.0024950013030320406,
-0.03136735409498215,
0.005857211071997881,
-0.0307077094912529,
0.023588068783283234,
0.0010399393504485488,
-0.010793191380798817,
-0.035370729863643646,
-0.0063007669523358345,
0.004839307628571987,
-0.0005487581365741789,
-0.02547602541744709,
0.028978979215025902,
-0.019914517179131508,
-0.005919763818383217,
0.021063214167952538,
0.04280881956219673,
-0.03828227519989014,
0.008370693773031235,
-0.0056212167255580425,
0.03837326169013977,
0.02486187033355236,
-0.08798327296972275,
-0.019766665995121002,
0.006249587517231703,
-0.015296988189220428,
-0.004947353154420853,
-0.0009987113298848271,
-0.022575853392481804,
-0.014785192906856537,
0.0030963607132434845,
-0.039533331990242004,
-0.01644568331539631,
-0.02961587905883789,
0.0443328320980072,
-0.007318670395761728,
-0.008495799265801907,
-0.0024864713195711374,
-0.035552702844142914,
-0.06278020143508911,
-0.021620500832796097,
0.021643247455358505,
-0.007267490960657597,
0.011691675521433353,
-0.007676927372813225,
0.03589389845728874,
-0.04148952662944794,
0.03773636370897293,
-0.016138607636094093,
-0.00004740324948215857,
-0.036303333938121796,
-0.02440694160759449,
-0.00561553006991744,
0.03625784441828728,
-0.02734123356640339,
0.03901016339659691,
-0.002082721795886755,
-0.03330080583691597,
0.028296584263443947,
-0.0036849251482635736,
0.02013060823082924,
-0.003261272329837084,
0.006772755645215511,
-0.008564039133489132,
0.03700847551226616,
0.01741240732371807,
-0.047631070017814636,
-0.005078145302832127,
-0.013886707834899426,
0.012248964048922062,
0.010144917294383049,
-0.018686208873987198,
0.03778185322880745,
-0.05222585052251816,
-0.022018564864993095,
0.028660528361797333,
-0.02165462076663971,
-0.005345415789633989,
-0.007381223142147064,
0.04110283777117729,
0.02179110050201416,
0.0035740360617637634,
-0.007494955789297819,
0.018629344180226326,
0.03641706705093384,
-0.027227502316236496,
0.014876178465783596,
-0.04376417025923729,
0.002187924226745963,
0.04042044281959534,
-0.03143559396266937,
0.048131488263607025,
0.010014125145971775,
-0.0018851121421903372,
-0.054864440113306046,
0.012658399529755116,
-0.0009916031267493963,
-0.00014394237950909883,
0.005243056919425726,
-0.0001525611587567255,
0.008063617162406445,
0.02258722484111786,
0.004034651909023523,
-0.018913673236966133,
-0.025066588073968887,
-0.006078988779336214,
-0.038782697170972824,
-0.017469273880124092,
-0.0013917984906584024,
0.009377224370837212,
0.012897237204015255,
-0.005342572461813688,
-0.02013060823082924,
-0.01671864092350006,
0.011538137681782246,
0.007620061282068491,
-0.006505485158413649,
0.00044142332626506686,
-0.03543896973133087,
-0.007631434127688408,
-0.0035370730329304934,
-0.010651025921106339,
0.05632021278142929,
-0.01567230559885502,
-0.017446527257561684,
-0.014318890869617462,
-0.023610815405845642,
-0.0018168727401643991,
0.00006326356378849596,
0.013181568123400211,
0.017423780634999275,
-0.013909454457461834,
0.03343728184700012,
0.016946105286478996,
0.014387129805982113,
-0.00913270004093647,
0.0008927981834858656,
-0.0038015006575733423,
0.025225814431905746,
0.004236526321619749,
0.018674835562705994,
0.016764134168624878,
0.06073302403092384,
0.024930110201239586,
-0.022746451199054718,
-0.00525443023070693,
0.015296988189220428,
0.022735077887773514,
0.03227721527218819,
0.018072055652737617,
0.035666435956954956,
-0.025066588073968887,
-0.0008679192396812141,
-0.026931798085570335,
0.017480647191405296,
-0.01135047897696495,
0.006044869311153889,
0.023997506126761436,
0.0013349322834983468,
0.06136992573738098,
-0.014944418333470821,
0.015058150514960289,
-0.0003543470520526171,
-0.0060334959998726845,
-0.021074587479233742,
-0.0003902438038494438,
0.019618814811110497,
-0.008876802399754524,
-0.058549363166093826,
0.007312983740121126,
-0.018470117822289467,
-0.006420185789465904,
-0.004660178907215595,
0.008581098169088364,
0.028933485969901085,
0.04003375396132469,
-0.010929669253528118,
0.029752356931567192,
0.029843343421816826,
-0.003940822556614876,
-0.007819092832505703,
0.02991158328950405,
-0.042604103684425354,
0.04972374066710472,
-0.03325531259179115,
-0.026931798085570335,
-0.010520233772695065,
-0.02900172583758831,
0.000528144184499979,
-0.00871757697314024,
0.037986572831869125,
-0.0053368862718343735,
0.009542136453092098,
-0.056866127997636795,
0.05295373871922493,
-0.009405657649040222,
-0.025680743157863617,
0.001092540449462831,
0.04437832534313202,
0.02825109288096428,
0.01903877966105938,
0.03603037819266319,
0.004401438403874636,
0.021245185285806656,
0.0216318741440773,
0.04226290434598923,
0.023997506126761436,
-0.05682063475251198,
-0.006573724094778299,
-0.02961587905883789,
0.023815535008907318,
0.02577172964811325,
0.0012844636803492904,
-0.025089334696531296,
-0.011003595776855946,
0.049678247421979904,
-0.0020286990329623222,
0.007847525179386139,
-0.031071651726961136,
0.008069303818047047,
-0.011850900948047638,
-0.03189052268862724,
-0.07792934030294418,
0.01727592945098877,
0.03220897540450096,
-0.01311332918703556,
0.003915233071893454,
0.014273397624492645,
0.016946105286478996,
-0.03575742244720459,
-0.007870271801948547,
0.060232602059841156,
-0.02640862949192524,
0.07301610708236694,
-0.025407785549759865,
0.042604103684425354,
0.02979785017669201,
0.017139451578259468,
0.007341417018324137,
-0.0037218879442662,
-0.04681219533085823,
0.0025859870947897434,
-0.04917782545089722,
-0.011509704403579235,
-0.015342481434345245,
-0.019937263801693916,
-0.021756980568170547,
0.010059617459774017,
0.050269655883312225,
0.032914113253355026,
0.010542980395257473,
0.002347149420529604,
-0.017537513747811317,
0.04053417593240738,
0.010463367216289043,
0.023565324023365974,
0.009388597682118416,
0.01844737119972706,
0.004378691781312227,
-0.0039038595277816057,
0.008382067084312439,
0.002125371480360627,
0.0696951225399971,
0.027659684419631958,
-0.013329420238733292,
-0.030184540897607803,
-0.03327805921435356,
-0.005129324737936258,
0.04574311152100563,
-0.03512052074074745,
-0.008996221236884594,
-0.010036871768534184,
-0.017617126926779747,
0.011208313517272472,
0.003076457418501377,
0.018470117822289467,
0.06528231501579285,
0.029115457087755203,
-0.0029627252370119095,
0.02072201669216156,
0.017503393813967705,
0.013761602342128754,
0.011896394193172455,
-0.002477941568940878,
-0.0001873028086265549,
0.03759988397359848,
0.02916095033288002,
-0.031685806810855865,
0.005058242008090019,
-0.015956634655594826,
0.014637340791523457,
0.011725795455276966,
0.007546135224401951,
0.000018292677850695327,
-0.0015467586927115917,
-0.0025419159792363644,
0.015717796981334686,
-0.025567010045051575,
0.02133617177605629,
-0.039965514093637466,
-0.020972227677702904,
-0.015410720370709896,
-0.019323110580444336,
0.009274865500628948,
-0.03441537916660309,
0.016036247834563255,
0.019743919372558594,
-0.00404602475464344,
-0.015524452552199364,
-0.006505485158413649,
0.02034670114517212,
-0.003042337717488408,
-0.013158821500837803,
0.0004982894170098007,
-0.019687052816152573,
-0.009951571933925152,
-0.010446307249367237,
-0.02502109669148922,
-0.019027406349778175,
-0.007506328634917736,
0.008603844791650772,
0.007915765047073364,
0.0061699748039245605,
0.04239938408136368,
-0.0030309646390378475,
-0.0018936420092359185,
0.018197160214185715,
-0.03557544946670532,
-0.02016472816467285,
-0.050269655883312225,
0.05559232458472252,
-0.009837839752435684,
-0.052589792758226395,
0.003013904672116041,
0.009434090927243233,
-0.015842903405427933,
0.004173973575234413,
0.014978538267314434,
-0.0027110925875604153,
0.028774259611964226,
0.006243900861591101,
0.012010126374661922,
-0.013852588832378387,
0.014762446284294128,
0.0071139526553452015,
0.005643963348120451,
-0.018037935718894005,
0.026658840477466583,
-0.0035569763276726007,
-0.017526140436530113,
-0.015638185665011406,
-0.0019021719926968217,
0.025589756667613983,
-0.003756007645279169,
0.0162864588201046,
-0.0022945483215153217,
0.01719631627202034,
0.015535825863480568,
0.012419561855494976,
-0.01305646263062954,
0.0012290191370993853,
0.019425468519330025,
-0.021211065351963043,
-0.02048317901790142,
0.012408188544213772,
0.0279098954051733,
0.012055618688464165,
-0.0040403385646641254,
-0.0061017354018986225,
0.013761602342128754,
-0.004634589422494173,
-0.018003815785050392,
0.049814727157354355,
-0.013010970316827297,
-0.04017023369669914,
0.044423818588256836,
-0.0061699748039245605,
-0.002664178144186735,
-0.005297079682350159,
0.012032872065901756,
0.007347103673964739,
-0.011515391059219837,
-0.006545291282236576,
0.008655024692416191,
0.021085960790514946,
-0.00686942832544446,
-0.004515170585364103,
0.021154198795557022,
-0.03405143693089485,
-0.017457900568842888,
-0.023110393434762955,
0.008103422820568085,
-0.003306765342131257,
0.024793632328510284,
-0.04224015772342682,
0.01467146072536707,
-0.008819936774671078,
0.007415343075990677,
0.05604725331068039,
0.026454122737050056,
-0.011088894680142403,
-0.016115861013531685,
-0.008256961591541767,
0.005720732267946005,
-0.0020031093154102564,
-0.020255714654922485,
0.012294456362724304,
-0.0169574785977602,
-0.04312727227807045,
-0.027409473434090614,
0.00421946682035923,
0.0052885496988892555,
-0.018174413591623306,
-0.014842059463262558,
0.018003815785050392,
-0.001923496718518436,
-0.00018010569328907877,
0.004978629294782877,
-0.0005167709314264357,
0.008990534581243992,
-0.012635653838515282,
0.009092893451452255,
-0.04799501225352287,
0.010958102531731129,
0.0060334959998726845,
-0.0031532268039882183,
-0.0015325421700254083,
0.04114833101630211,
-0.00002750010389718227,
0.017958322539925575,
0.003460303880274296,
0.006659023463726044,
-0.019288990646600723,
-0.0019931576680392027,
-0.0574120432138443,
0.018379133194684982,
-0.020358074456453323,
-0.004483893979340792,
-0.008973474614322186,
-0.0232354998588562,
-0.010787504725158215,
-0.001393220154568553,
0.005746322218328714,
-0.02208680473268032,
0.002239103661850095,
-0.004242212977260351,
-0.012624280527234077,
0.02296254225075245,
0.0148875517770648,
0.02795538865029812,
-0.0077451663091778755,
0.02050592564046383,
0.01342040579766035,
0.0034119675401598215,
-0.0023030780721455812,
0.002122528152540326,
-0.035211507230997086,
0.02331511303782463,
-0.007944198325276375,
0.008228528313338757,
-0.027204755693674088,
0.014807939529418945,
0.00874601025134325,
0.00852991919964552,
0.03496129438281059,
-0.007335730362683535,
0.03880544379353523,
-0.01933448389172554,
-0.00932035781443119,
-0.001910701859742403,
0.0040602413937449455,
0.02296254225075245,
0.020392192527651787,
0.017310049384832382,
-0.028524048626422882,
-0.0007811984396539629,
-0.04296804592013359,
0.009672928601503372,
-0.03175404667854309,
-0.020153354853391647,
-0.0022547419648617506,
0.02795538865029812,
-0.027136515825986862,
0.001667599193751812,
0.01698022522032261,
-0.0005800345097668469,
-0.010247276164591312,
-0.002721044234931469,
-0.005570037290453911,
-0.007375536486506462,
-0.013488645665347576,
-0.012055618688464165,
0.007989690639078617,
0.004500953946262598,
0.0021282148081809282,
0.015240122564136982,
-0.005612686742097139,
-0.031390100717544556,
0.0347110852599144,
0.019107019528746605,
-0.014921671710908413,
-0.04446931183338165,
-0.017344169318675995,
0.019505081698298454,
-0.013579631224274635,
-0.0061699748039245605,
0.018731702119112015,
0.0010086629772558808,
-0.016195472329854965,
-0.03282313048839569,
0.028455810621380806,
-0.0029883149545639753,
0.008910922333598137,
-0.014057306572794914,
-0.01874307543039322,
-0.0011828154092654586,
-0.019778039306402206,
-0.01824265345931053,
0.00732435705140233,
-0.0035967824514955282,
-0.0008245588396675885,
-0.04312727227807045,
-0.0000704606864019297,
-0.0017927046865224838,
-0.012567413970828056,
-0.022837435826659203,
0.009195252321660519,
-0.0004790971288457513,
-0.04740360379219055,
-0.08206919580698013,
-0.01105477474629879,
0.02309902012348175,
-0.03268665075302124,
0.009485269896686077,
-0.03280038386583328,
0.019129764288663864,
0.06405400484800339,
-0.013613751158118248,
-0.004245056305080652,
0.016832374036312103,
0.006397439166903496,
-0.010889863595366478,
0.031549327075481415,
0.0035797227174043655,
0.03728143125772476,
-0.025680743157863617,
-0.015308361500501633,
-0.0052203102968633175,
-0.010975162498652935,
0.021085960790514946,
0.015376600436866283,
0.03295960649847984,
0.02262134477496147,
0.0017244652844965458,
0.031094398349523544,
0.01065671257674694,
-0.035689182579517365,
0.0168210007250309,
-0.020062370225787163,
0.012533294036984444,
0.013511392287909985,
-0.004890487063676119,
-0.00797263067215681,
0.0046033128164708614,
0.011657556518912315,
-0.00698884716257453,
-0.000007619172720296774,
0.022712331265211105,
0.010588472709059715,
-0.017184942960739136,
-0.007568881381303072,
0.014114173129200935,
0.004597626160830259,
0.0018822688143700361,
-0.015262868255376816,
-0.010787504725158215,
-0.024497928097844124,
0.0015965165803208947,
-0.02040356583893299,
0.00423936964944005,
-0.004020435269922018,
0.01212385855615139,
-0.000014938465028535575,
-0.011157134547829628,
0.023974759504199028,
0.012169350869953632,
0.011191253550350666,
-0.020062370225787163,
-0.0027850186452269554,
-0.006442932412028313,
-0.00817166268825531,
-0.004409968387335539,
-0.012294456362724304,
-0.01626371219754219,
-0.029229190200567245,
0.02934292145073414,
-0.010395128279924393,
-0.005197564139962196,
-0.000938291079364717,
0.020255714654922485,
-0.01703709177672863,
-0.008325201459228992,
-0.014375757426023483,
0.026977291330695152,
-0.004279176238924265,
0.017480647191405296,
-0.029524892568588257,
-0.030025314539670944,
-0.013704736717045307,
-0.01828814670443535,
-0.0020087959710508585,
0.019982757046818733,
-0.04544740915298462,
0.0058344644494354725,
0.01188502088189125,
0.006209780927747488,
0.005999376531690359,
-0.006351946387439966,
0.00020720595784951001,
0.0006777731468901038,
-0.028160106390714645,
0.009053087793290615,
0.03762263059616089,
0.05463697388768196,
-0.011595003306865692,
0.0035171699710190296,
0.009058774448931217,
-0.025248561054468155,
0.027591444551944733,
-0.00679550226777792,
-0.029752356931567192,
-0.008217155002057552,
-0.018549731001257896,
0.027432220056653023,
-0.0074437758885324,
0.017719484865665436,
-0.010503173805773258,
0.026772573590278625,
-0.0360531248152256,
0.02825109288096428,
-0.002618685131892562,
-0.009195252321660519,
0.03330080583691597,
0.06214330345392227,
-0.025839967653155327,
-0.011839527636766434,
0.022234655916690826,
-0.009343104436993599,
-0.013886707834899426,
0.014091426506638527,
0.024770885705947876,
-0.006494111847132444,
-0.021211065351963043,
0.019721172749996185,
0.029524892568588257,
-0.011060461401939392,
0.018015189096331596,
-0.03255017101764679,
-0.01759438030421734,
0.011526764370501041,
-0.03805481269955635,
0.015558572486042976,
0.002846149727702141,
0.032936859875917435,
0.006926294416189194,
0.018094802275300026,
-0.04155776649713516,
-0.014603221789002419,
-0.02016472816467285,
-0.029866090044379234,
0.004617529455572367,
0.006078988779336214,
0.005083831958472729,
0.014989911578595638,
0.011782662011682987,
0.005663866177201271,
0.0408526249229908,
0.02688630484044552,
-0.008808563463389874,
0.03407418355345726,
-0.028182853013277054,
-0.009479583241045475,
0.0336420014500618,
-0.010179037228226662,
0.015376600436866283,
0.009024654515087605,
0.0006358344107866287,
0.008706203661859035,
0.03411967679858208,
0.0237700417637825,
-0.01059984602034092,
-0.005697986111044884,
-0.02811461314558983,
0.014250651933252811,
-0.026272151619195938,
0.012783505022525787,
0.09608101099729538,
-0.017924202606081963,
0.001003687153570354,
0.02838757075369358,
0.001717357081361115,
0.006192721426486969,
0.03755439072847366,
-0.0020059526432305574,
0.02731848694384098,
-0.012032872065901756,
0.020813003182411194,
0.019914517179131508,
0.013079209253191948,
0.02411123737692833,
0.05668415501713753,
-0.004981472622603178,
0.010446307249367237,
0.033846717327833176,
-0.014034559950232506,
-0.020062370225787163,
0.036940235644578934,
0.02293979562819004,
-0.011657556518912315,
0.005390909034758806,
0.00379581400193274,
0.016616282984614372,
0.0013072100700810552,
-0.021006347611546516,
0.01219209749251604,
-0.01556994579732418,
0.0025177476927638054,
-0.02064240351319313,
0.01093535590916872,
-0.018549731001257896,
-0.00009844948363024741,
-0.030002567917108536,
0.0058856443502008915,
-0.011339105665683746,
0.013454525731503963,
-0.010832997038960457,
0.0015026874607428908,
0.013522764667868614,
0.026931798085570335,
0.011066148057579994,
0.011327732354402542,
0.019448215141892433,
-0.031117144972085953,
0.007421029731631279,
0.006323513574898243,
-0.01344315242022276,
0.01173716876655817,
0.018913673236966133,
-0.006653336808085442,
-0.015103643760085106,
-0.04017023369669914,
-0.02192757837474346,
0.004953039810061455,
-0.019107019528746605,
-0.0034716769587248564,
-0.030889680609107018,
-0.020449059084057808,
0.001876582158729434,
0.019027406349778175,
-0.01850423775613308,
0.01101496908813715
] | 2025-01-08 | 101 | 39769267 | [
"T cell receptor",
"recombinant T cells",
"T cell",
"T cells",
"different recombinant T cells",
"TCR)-engineered T cell therapies",
"intracellular neoantigens",
"TCR",
"neoantigens",
"T cell-based therapies",
"the synthetic T cell receptor",
"antigen receptor",
"immune checkpoint blocking antibodies",
"antigen peptide presentation",
"anti-neopeptide MHC",
"clinical interest",
"tumor heterogenicity",
"variable regions",
"TCR-like CAR-T cell",
"TCR-CAR-T cell",
"TCR-like CAR",
"a recombinant complete TCR",
"different limitations",
"enhanced therapeutic functions",
"CAR",
"(TCR-T cell",
"TCR-Cα",
"TCR-Cβ",
"cancer patients",
"a chimeric antigen receptor"
] | [
"CD3 × TCR-like antibody)",
"CRISPR/Cas9-based genome editing",
"STARs",
"T CARs",
"TCR-CARs",
"TCR-like CARs",
"TCR-like antibodies",
"bispecific antibody (CD3 × TCR",
"checkpoint blocking antibodies",
"intrabodies",
"neoantigens",
"therapeutic mRNA"
] | 0 | 10.3390/ijms252413504
10.20517/2394-4722.2017.41
10.1186/s13045-019-0788-4
10.3390/antib11030049
10.1158/1078-0432.CCR-22-0028
10.3389/fimmu.2023.1121030
10.1016/j.ijbiomac.2022.03.113
10.3389/fonc.2022.836821
10.1038/s41392-022-01270-x
10.1038/s41598-024-58094-8
10.1016/j.intimp.2024.112730
10.1016/j.ejphar.2024.176727
10.3389/fimmu.2021.690499
10.3389/fimmu.2020.01689
10.1038/s41467-023-38946-z
10.1038/s41591-019-0596-y
10.3389/fimmu.2022.835762
10.1038/s41417-021-00307-7
10.1158/2767-9764.CRC-21-0154
10.1126/scitranslmed.abb5191
10.3389/fimmu.2017.01848
10.3389/fimmu.2017.01718
10.1158/2326-6066.CIR-19-0401
10.3390/cancers13164245
10.3389/fimmu.2021.688183
10.3389/fimmu.2023.1146826
10.1126/sciimmunol.abg2200
10.1038/s41587-023-01945-y
10.3389/fonc.2020.01347
10.1038/s41596-019-0170-6
10.1038/s43018-023-00642-8
10.1038/s41586-022-05531-1
10.1080/21645515.2023.2210046
10.1056/NEJMoa2213614
10.1038/s41591-024-03326-7
10.1038/s41586-024-07233-2
10.1158/2767-9764.CRC-22-0486
10.1038/s41591-024-03109-0
10.1080/2162402X.2020.1869389
10.1016/j.ccell.2020.07.013
10.1172/JCI123791
10.1158/2326-6066.CIR-22-0040
10.1056/NEJMoa2119662
10.1038/s41591-022-01786-3
10.1038/d41573-024-00134-z
10.1016/S0140-6736(24)00319-2
10.1126/science.1251102
10.1038/s41598-017-11126-y
10.1016/j.omton.2024.200797
10.1016/j.ymthe.2024.01.018
10.1136/jitc-2023-007199
10.1016/j.it.2016.06.005
10.1038/s41598-019-53756-4
10.1038/s41568-023-00586-2
10.1038/s41591-022-02061-1
10.1038/s41467-020-19486-2
10.1039/D2NR05949E
10.1038/s41587-022-01245-x
10.1038/s41596-021-00510-8
10.3390/ijms232213735
10.3390/molecules27238363
10.1021/acsnanoscienceau.2c00062
10.1073/pnas.2304966120
10.1093/abt/tbz001
10.1158/1535-7163.MCT-21-0115
10.1111/febs.15780
10.1172/JCI130562
10.1038/s41587-022-01282-6
10.1038/s41573-023-00809-z
10.1126/science.abc8697
10.1126/sciimmunol.abd5515
10.1038/s41467-024-50462-2
10.1093/braincomms/fcae100
10.1038/s41467-024-47062-5
10.3390/molecules27072198
10.1093/abt/tbaa001
10.3390/antib12010024
10.3390/cells12010027
10.1038/s41596-019-0133-y
10.1007/s00281-024-01011-y
10.1016/j.ymthe.2023.06.015
10.1016/S1470-2045(20)30011-5
10.1200/JCO.19.00934
10.1056/NEJMoa1003466
10.2147/IJN.S424872
10.3389/fimmu.2023.1267918
10.1126/sciadv.adf3700
10.1126/science.aba7365
10.1097/CJI.0000000000000119
10.1016/j.immuni.2023.05.008
10.1038/s43018-024-00780-7
10.1016/j.jceh.2024.101440
10.4081/aiua.2024.12307
10.1038/s41573-023-00671-z
10.1016/j.omto.2022.03.009
10.3390/cancers12082175
10.1136/jitc-2021-003715
10.1038/s41591-023-02785-8
10.1038/s41467-021-26936-y
10.1038/s43018-024-00768-3
10.3390/antib13010011 | [
"Waaga-Gasser",
"Böldicke"
] | [
"Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.",
"Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany."
] | [
"39769267",
"31521180",
"35892709",
"36255733",
"36949949",
"35339499",
"35311072",
"36604431",
"38548901",
"39083927",
"38866361",
"34140957",
"33013822",
"37280206",
"31591590",
"35309357",
"33654227",
"36923303",
"33762437",
"29312332",
"29321773",
"31907209",
"34439399",
"34659196",
"37180102",
"37027480",
"37857725",
"32850430",
"31101906",
"37783807",
"36356599",
"37185251",
"36762851",
"39528665",
"38538786",
"37377890",
"38992129",
"33520408",
"32822573",
"30714987",
"35749374",
"35648703",
"35484264",
"39152243",
"38554725",
"24812403",
"28878363",
"38601972",
"38243600",
"37586774",
"27364960",
"31754147",
"37311817",
"36357682",
"33247092",
"36472072",
"35332339",
"33846629",
"36430214",
"36500454",
"37360845",
"37878720",
"33928218",
"34172530",
"33624424",
"32310221",
"35332342",
"37891435",
"33649166",
"33649101",
"36199496",
"39025931",
"38585667",
"38627373",
"35408597",
"32118195",
"36975371",
"36611821",
"31092913",
"39060547",
"37408308",
"32112738",
"31154919",
"20525992",
"37795042",
"37881432",
"36791198",
"32029687",
"27070449",
"37315535",
"38918437",
"38975606",
"38818794",
"37041221",
"35434273",
"32764348",
"35288464",
"38238616",
"34795224",
"38750245",
"38390872"
] | [] | 9.372404 | 4.370181 |
39768494 | 64 | Emergencies in Hematology: Why, When and How I Treat? | Hematological emergencies are critical medical conditions that require immediate attention due to their rapid progression and life-threatening nature. As various examples, hypercalcemia, often associated with cancers such as multiple myeloma, can lead to severe neurological and cardiac dysfunction. Hyperleukocytosis, common in acute myeloid leukemias, increases the risk of leukostasis and multiorgan failure. Sickle cell crisis, a common complication in sickle cell disease, results from vaso-occlusion, leading to acute pain and tissue ischemia. Tumor lysis syndrome, reported in cases of rapid destruction of cancer cells, causes electrolyte imbalances and acute kidney injury. Acute transfusion reactions, fundamental in hematological conditions, can range from mild allergic responses to severe hemolysis and shock, requiring prompt management. Disseminated intravascular coagulation, involving excessive coagulation and bleeding, is commonly triggered by hematological malignancies, common in the first phases of acute promyelocytic leukemia. Recently, in the era of bispecific antibodies and chimeric antigen receptor T cells, cytokine release syndrome is a manifestation that must be recognized and promptly treated. Understanding the pathophysiology, recognizing the clinical manifestations, and ensuring adequate diagnostic strategies and management approaches for each condition are central to early intervention in improving patient outcomes and reducing mortality. | [
-0.00677148113027215,
0.04398293048143387,
0.07127632200717926,
0.07081528753042221,
-0.025979435071349144,
-0.010125525295734406,
0.04059430956840515,
0.006990473717451096,
-0.012978192418813705,
-0.003515407210215926,
0.031235257163643837,
-0.012909036129713058,
-0.07916005700826645,
-0.00043294255738146603,
0.03427810221910477,
-0.01101878471672535,
0.029967406764626503,
0.030474547296762466,
0.0068521625362336636,
0.008655969984829426,
0.017438724637031555,
0.014038576744496822,
0.04534298926591873,
0.02803105115890503,
-0.02098871022462845,
-0.013231762684881687,
0.005837881006300449,
0.011998488567769527,
0.005837881006300449,
-0.029875198379158974,
0.04036379233002663,
-0.01415383629500866,
0.04370630905032158,
0.0015415925299748778,
-0.021749421954154968,
0.07086139172315598,
-0.012862932868301868,
0.069524385035038,
-0.017358044162392616,
-0.0067426664754748344,
0.006431466434150934,
-0.03296414762735367,
-0.04808615893125534,
0.051682248711586,
-0.06353089958429337,
-0.03363265097141266,
0.042138781398534775,
-0.07413475215435028,
0.04264592379331589,
0.006270103622227907,
0.0012368758907541633,
0.0019853406120091677,
-0.005408540368080139,
0.02586417645215988,
0.0056448220275342464,
0.03351739048957825,
-0.014799288474023342,
0.05043745040893555,
-0.0025875703431665897,
-0.08874962478876114,
0.015387110412120819,
-0.019432710483670235,
-0.032180383801460266,
-0.018671998754143715,
0.0010495795868337154,
-0.004034074023365974,
-0.03317161276936531,
-0.05615430697798729,
-0.014845391735434532,
-0.0037747405003756285,
0.019686279818415642,
-0.031604088842868805,
0.020297154784202576,
0.002743170130997896,
-0.013865687884390354,
-0.00197093328461051,
-0.045366041362285614,
0.008702073246240616,
-0.024066131561994553,
0.006806058809161186,
0.033794011920690536,
-0.036076147109270096,
0.04269202798604965,
-0.016781747341156006,
-0.04068651795387268,
0.015606102533638477,
-0.03068201243877411,
0.01975543610751629,
-0.04123976081609726,
-0.010430962778627872,
-0.03875016048550606,
-0.006788770202547312,
-0.0215765330940485,
0.04359104856848717,
-0.02717813290655613,
-0.017634665593504906,
0.01966322958469391,
-0.019501864910125732,
-0.013566014356911182,
0.0788373276591301,
0.025702813640236855,
-0.005970429163426161,
-0.01815333217382431,
-0.02526482753455639,
0.036168355494737625,
-0.03144272416830063,
-0.015018280595541,
-0.01022349577397108,
0.011785258539021015,
-0.044236499816179276,
0.053065359592437744,
-0.009255317971110344,
-0.05703027918934822,
0.053065359592437744,
-0.013531436212360859,
-0.06615880876779556,
-0.05965818837285042,
-0.017749924212694168,
-0.006638932973146439,
0.04914654418826103,
-0.014003999531269073,
0.041862159967422485,
-0.012655465863645077,
0.000617357378359884,
-0.03884236887097359,
-0.03070506453514099,
0.07067697495222092,
0.01059808861464262,
0.043959878385066986,
-0.05366470664739609,
0.044328708201646805,
-0.011906281113624573,
-0.0016222740523517132,
-0.04914654418826103,
-0.04882381856441498,
0.03603004291653633,
0.015940355136990547,
-0.029345005750656128,
-0.00572838494554162,
-0.02946026436984539,
-0.01585967279970646,
0.023339997977018356,
0.022348769009113312,
-0.011278118006885052,
-0.033770959824323654,
0.017127525061368942,
0.006685036700218916,
0.022636916488409042,
-0.012724621221423149,
0.012978192418813705,
0.033609598875045776,
0.04693356901407242,
0.012471050955355167,
0.017346518114209175,
0.009756695479154587,
-0.03280278295278549,
0.037205688655376434,
0.04287644103169441,
-0.009946873411536217,
-0.05938156694173813,
-0.0033886220771819353,
0.015456265769898891,
-0.010753688402473927,
-0.0257719699293375,
0.026371316984295845,
-0.035799525678157806,
-0.02650962769985199,
0.042991701513528824,
0.005719740409404039,
-0.024388857185840607,
-0.008436976931989193,
-0.027316443622112274,
-0.1015203520655632,
0.007192177232354879,
0.00854647345840931,
0.012401895597577095,
0.027016768231987953,
-0.008494607172906399,
-0.006558251567184925,
-0.0013564573600888252,
0.030658962205052376,
0.03201901912689209,
0.027961894869804382,
0.00869054812937975,
-0.027777479961514473,
0.013439228758215904,
-0.03499270975589752,
0.0015689665451645851,
-0.03351739048957825,
-0.031511880457401276,
0.017185155302286148,
-0.0024449368938803673,
-0.020308680832386017,
-0.030866427347064018,
0.014338251203298569,
-0.016689540818333626,
0.026348264887928963,
0.02992130257189274,
-0.023881716653704643,
-0.0609951987862587,
0.045273832976818085,
-0.013715851120650768,
-0.022083673626184464,
-0.03118915483355522,
-0.0015300665982067585,
-0.00940515473484993,
-0.04725629463791847,
0.02489599958062172,
0.03148882836103439,
0.02973688766360283,
0.019029302522540092,
0.011410665698349476,
0.015640681609511375,
0.03990275412797928,
-0.010984206572175026,
-0.01890251785516739,
-0.025679761543869972,
0.03466998413205147,
0.004365444183349609,
-0.01769229583442211,
0.0023181517608463764,
-0.007912547327578068,
0.0039044071454554796,
0.03420894593000412,
-0.05693807080388069,
-0.031050842255353928,
0.01748482882976532,
-0.01815333217382431,
0.019893746823072433,
0.005010895896703005,
0.02271759882569313,
-0.005382607225328684,
0.04882381856441498,
-0.00874817743897438,
-0.009733644314110279,
-0.022648442536592484,
-0.0013917555334046483,
0.04704882577061653,
0.036537181586027145,
-0.017277361825108528,
0.056799761950969696,
0.022002991288900375,
-0.01740414649248123,
0.017715347930788994,
0.008840384893119335,
-0.014983703382313251,
0.03079727292060852,
-0.032825835049152374,
0.012540207244455814,
0.03116610273718834,
-0.008517659269273281,
-0.036260560154914856,
-0.001182848121970892,
-0.011110992170870304,
0.0050080143846571445,
-0.017922813072800636,
-0.0006270823650993407,
-0.02309795469045639,
-0.04402903467416763,
0.007128784898668528,
-0.022291138768196106,
0.016689540818333626,
-0.009065140038728714,
-0.023593569174408913,
-0.011796784587204456,
-0.029022280126810074,
0.011998488567769527,
0.010534695349633694,
0.008200695738196373,
-0.0033742147497832775,
0.031050842255353928,
0.04762512445449829,
0.01769229583442211,
-0.03914204239845276,
-0.05435626581311226,
0.007549481000751257,
0.019836118444800377,
0.022268088534474373,
-0.027708323672413826,
0.07072307914495468,
0.002055936958640814,
0.007007762789726257,
-0.0018931332742795348,
-0.03167324140667915,
-0.03828912228345871,
0.024089183658361435,
-0.026855405420064926,
-0.0035211702343076468,
0.011658473871648312,
-0.019617125391960144,
-0.035107970237731934,
0.024550221860408783,
-0.01002755481749773,
0.01559457741677761,
0.010252310894429684,
0.0072555700317025185,
-0.02127685770392418,
0.043291375041007996,
-0.0533880852162838,
0.01149711012840271,
-0.012321214191615582,
-0.01901777647435665,
-0.046518635004758835,
-0.01041367370635271,
0.038335226476192474,
0.0024622257333248854,
-0.012436473742127419,
-0.010263836942613125,
0.020320206880569458,
-0.0027878331020474434,
0.016885479912161827,
-0.007658977527171373,
0.046126753091812134,
0.04174690321087837,
-0.017657717689871788,
0.005541088525205851,
0.014833865687251091,
-0.0270859245210886,
0.0317423976957798,
-0.04942316934466362,
-0.021634161472320557,
-0.016216976568102837,
-0.013612117618322372,
-0.004604607354849577,
-0.009491599164903164,
-0.0037833850365132093,
0.02241792529821396,
0.026117747649550438,
0.01316260639578104,
-0.028007999062538147,
-0.015917303040623665,
-0.03259531781077385,
0.035015761852264404,
-0.0005737749743275344,
0.014015525579452515,
-0.02517262101173401,
0.022855909541249275,
-0.010073659010231495,
0.011099466122686863,
-0.029506368562579155,
-0.025518398731946945,
0.004088821820914745,
-0.020596828311681747,
0.005650585051625967,
-0.009883481077849865,
-0.06339258700609207,
-0.01795739121735096,
0.0007758388528600335,
0.01987069472670555,
0.02784663625061512,
-0.041954368352890015,
0.03969528526067734,
-0.03983359783887863,
0.062009479850530624,
-0.007261333055794239,
0.020009007304906845,
-0.020020531490445137,
0.003103355411440134,
0.0003452374949119985,
-0.0028512259013950825,
0.01149711012840271,
-0.029437214136123657,
-0.017634665593504906,
0.03840438276529312,
0.04363715276122093,
0.08091199398040771,
-0.011739155277609825,
-0.020170370116829872,
-0.042069628834724426,
-0.04098619148135185,
-0.016228502616286278,
0.0448589026927948,
-0.0022144184913486242,
-0.007947125472128391,
-0.05343418940901756,
0.045850131660699844,
-0.003976444248110056,
-0.0104597769677639,
0.007624399848282337,
0.054217953234910965,
0.03923425078392029,
0.012793777510523796,
0.007376592140644789,
-0.00893259234726429,
0.018015021458268166,
0.0279388427734375,
-0.03533848747611046,
-0.04059430956840515,
-0.04382156953215599,
0.04739460349082947,
0.024089183658361435,
-0.01748482882976532,
-0.021645687520503998,
0.018499109894037247,
-0.03695211559534073,
0.027062872424721718,
-0.07431916892528534,
0.11341510713100433,
0.033309925347566605,
-0.021818576380610466,
0.013220236636698246,
-0.025034310296177864,
-0.0228904876857996,
-0.036929063498973846,
0.01226358488202095,
-0.022187406197190285,
0.02805410325527191,
0.01316260639578104,
0.010546221397817135,
-0.07178346067667007,
0.029621629044413567,
0.009964162483811378,
0.024020029231905937,
0.037113480269908905,
0.01664343662559986,
-0.019651703536510468,
-0.020550724118947983,
0.014096206985414028,
-0.04649558290839195,
0.041101448237895966,
0.013819584622979164,
-0.061917271465063095,
-0.01920219138264656,
0.021530428901314735,
-0.018683524802327156,
-0.06168675422668457,
0.020009007304906845,
-0.03402453288435936,
0.023535938933491707,
-0.038819316774606705,
-0.05255822092294693,
-0.027800532057881355,
0.02195688709616661,
0.028860917314887047,
0.02614079788327217,
0.0215765330940485,
-0.00032956941868178546,
0.009704829193651676,
0.008062385022640228,
0.021830102428793907,
-0.02480379119515419,
0.037874191999435425,
-0.015433213673532009,
0.008448502980172634,
0.044052086770534515,
0.0005590073997154832,
0.01576746627688408,
-0.0038986443541944027,
-0.016793273389339447,
0.02680930308997631,
0.0762094184756279,
-0.026163849979639053,
-0.000711725908331573,
0.01335854735225439,
0.0105923255905509,
-0.010206206701695919,
0.02773137576878071,
-0.07473409920930862,
-0.006079925689846277,
-0.009520414285361767,
-0.04077872261404991,
-0.0016525295795872808,
0.03614530339837074,
-0.00363642955198884,
-0.002537144348025322,
-0.01900625042617321,
-0.0066907997243106365,
-0.04644947871565819,
-0.01806112565100193,
-0.01558305136859417,
0.031212205067276955,
0.016389865428209305,
0.029483316466212273,
-0.02385866641998291,
0.009266844019293785,
0.037205688655376434,
0.02602553926408291,
-0.0001537990610813722,
0.01017162948846817,
0.05942767113447189,
-0.0039015256334096193,
-0.05085238441824913,
-0.026832353323698044,
-0.04416734725236893,
0.03669854626059532,
-0.017173629254102707,
-0.035868678241968155,
-0.00916887354105711,
-0.01663191057741642,
0.017922813072800636,
0.018291642889380455,
-0.000642570317722857,
0.020020531490445137,
-0.009854665957391262,
-0.003881355281919241,
0.025057362392544746,
-0.041585538536310196,
-0.010384858585894108,
0.02745475433766842,
-0.020700562745332718,
0.009779747575521469,
-0.01576746627688408,
-0.0051981923170387745,
0.008085436187684536,
0.05066796764731407,
-0.014407406561076641,
0.047348503023386,
0.033609598875045776,
-0.016862429678440094,
-0.0013305239845067263,
-0.014730132184922695,
0.006212473846971989,
0.045273832976818085,
-0.0038150812033563852,
-0.05467899143695831,
-0.05029913783073425,
-0.004826481454074383,
-0.023973925039172173,
-0.02897617593407631,
0.02851513959467411,
0.02357051707804203,
0.0019406776409596205,
0.012632413767278194,
-0.007163362577557564,
0.03752841427922249,
-0.03158103674650192,
-0.03609919920563698,
0.02317863516509533,
0.018268590793013573,
-0.03241090103983879,
-0.020873451605439186,
-0.014222991652786732,
0.0007412610575556755,
0.04402903467416763,
-0.018602844327688217,
-0.00039152128738351166,
-0.01558305136859417,
-0.01082860678434372,
-0.04326832294464111,
-0.028007999062538147,
0.004267473705112934,
0.001423451816663146,
0.018856413662433624,
-0.02005510963499546,
-0.005633295979350805,
-0.0008428333094343543,
0.006783007178455591,
0.01078826654702425,
0.01558305136859417,
-0.006321969907730818,
0.008759703487157822,
-0.019905272871255875,
-0.0013153962790966034,
-0.010200443677604198,
-0.0010337313869968057,
0.043867673724889755,
-0.009088192135095596,
-0.04744070768356323,
-0.02280980721116066,
-0.01421146560460329,
-0.0006800296250730753,
-0.027800532057881355,
-0.014499614015221596,
0.004843770060688257,
-0.03964918479323387,
0.014684028923511505,
-0.010528933256864548,
-0.00468240724876523,
-0.03563816100358963,
-0.0126900440081954,
-0.03118915483355522,
-0.0031148812267929316,
-0.01985916867852211,
0.0012793777277693152,
0.021242279559373856,
-0.0064141773618757725,
-0.009629910811781883,
0.007918310351669788,
-0.0030399628449231386,
-0.012148325331509113,
0.005129036959260702,
-0.00878851767629385,
-0.040064115077257156,
0.0030370813328772783,
-0.03296414762735367,
0.017991969361901283,
-0.021426694467663765,
0.013001243583858013,
-0.02574891783297062,
-0.004979199729859829,
0.062009479850530624,
0.009768221527338028,
0.03858879953622818,
0.05094458907842636,
-0.011370325461030006,
0.025795020163059235,
0.03194986656308174,
-0.030244028195738792,
0.031396619975566864,
0.0058494070544838905,
-0.025818072259426117,
-0.03224954009056091,
-0.017749924212694168,
-0.013128029182553291,
-0.010961155407130718,
0.0414472259581089,
0.027431702241301537,
-0.0036306665278971195,
-0.0032099701929837465,
0.021553480997681618,
0.03962613269686699,
0.006679273676127195,
-0.03413978964090347,
-0.007877970114350319,
0.0135429622605443,
0.019617125391960144,
-0.00468240724876523,
0.009053613990545273,
0.009733644314110279,
-0.013174132443964481,
0.0016107481205835938,
0.01378500647842884,
0.0220375694334507,
-0.03718263655900955,
0.03268752247095108,
-0.026855405420064926,
-0.023927820846438408,
-0.01060385163873434,
0.002058818470686674,
-0.009814325720071793,
0.0020861926022917032,
-0.04047904908657074,
-0.009341762401163578,
-0.027039820328354836,
0.010863184928894043,
0.04379851743578911,
0.0019406776409596205,
-0.05228159576654434,
-0.008102725259959698,
-0.025403140112757683,
-0.0007924073725007474,
0.009462784975767136,
-0.060119226574897766,
-0.044144295156002045,
0.004973436705768108,
-0.032272592186927795,
-0.030105717480182648,
0.010770977474749088,
0.03118915483355522,
-0.005203955341130495,
0.020838873460888863,
0.02279828116297722,
0.011531688272953033,
-0.024942101910710335,
0.015110488049685955,
-0.039487820118665695,
-0.022348769009113312,
-0.028077153488993645,
0.06523673981428146,
0.04121670871973038,
-0.015098962001502514,
0.003091829363256693,
0.015479317866265774,
0.047486811876297,
0.026209954172372818,
-0.014995228499174118,
0.01909845881164074,
-0.006321969907730818,
0.0035355775617063046,
0.015721362084150314,
0.03144272416830063,
0.03441641479730606,
0.023017272353172302,
0.005558377597481012,
0.020931079983711243,
0.014983703382313251,
0.001868640654720366,
0.014614873565733433,
-0.04179300367832184,
0.026002487167716026,
-0.0014565888559445739,
-0.008534947410225868,
-0.01588272489607334,
-0.042622871696949005,
-0.011721866205334663,
0.028445983305573463,
0.026763198897242546,
0.016113243997097015,
0.014338251203298569,
0.0009292777394875884,
0.028630398213863373,
0.01576746627688408,
-0.012413421645760536,
-0.019524917006492615,
0.0196747537702322,
0.016101717948913574,
-0.023927820846438408,
0.005201073829084635,
0.0075321923941373825,
-0.048040058463811874,
0.024020029231905937,
0.016562754288315773,
0.03333297744393349,
-0.05892052873969078,
0.023835614323616028,
-0.04451312497258186,
-0.0075552440248429775,
-0.005699570290744305,
0.017542459070682526,
0.028492087498307228,
0.0003002143348567188,
0.03870405629277229,
-0.005143444053828716,
0.0034318442922085524,
-0.018591318279504776,
-0.02906838431954384,
-0.005719740409404039,
0.003212851705029607,
-0.0006749869789928198,
0.020504621788859367,
0.011341510340571404,
0.003616258967667818,
-0.04873161390423775,
-0.026302162557840347,
0.00522412545979023,
0.03326382115483284,
-0.011381851509213448,
0.03828912228345871,
0.004083059262484312,
-0.007728132884949446,
0.005520918406546116,
-0.007313199806958437,
0.002158229472115636,
-0.0414472259581089,
0.0007664740551263094,
-0.0017101591220125556,
-0.00529616279527545,
-0.008782755583524704,
-0.04126281291246414,
-0.0036911775823682547,
0.03978749364614487,
-0.041285865008831024,
-0.024158339947462082,
0.028953123837709427,
-0.020838873460888863,
0.010442488826811314,
0.012079169973731041,
0.009053613990545273,
-0.005809066351503134,
-0.017242783680558205,
-0.033217716962099075,
0.007284384686499834,
-0.010142814368009567,
-0.016977688297629356,
0.036352768540382385,
-0.046242013573646545,
0.0003515407152008265,
0.01576746627688408,
-0.022394873201847076,
-0.03932645916938782,
0.0069674220867455006,
0.019144561141729355,
-0.02985214628279209,
0.02812325768172741,
0.0037689777091145515,
-0.041769955307245255,
0.03220343589782715,
0.04200047254562378,
-0.004477822221815586,
0.00425018509849906,
-0.006425703410059214,
-0.0055699036456644535,
0.011082177050411701,
-0.005131918471306562,
0.047486811876297,
0.017346518114209175,
-0.045089419931173325,
-0.007803051266819239,
0.025357035920023918,
-0.027616117149591446,
-0.011059124954044819,
-0.01604408770799637,
0.016032561659812927,
0.008419688791036606,
0.002852666424587369,
0.02842293120920658,
-0.004688170272856951,
-0.01064419187605381,
-0.03068201243877411,
-0.00912853330373764,
0.005647703539580107,
-0.0066907997243106365,
-0.02745475433766842,
0.007653214503079653,
-0.026947613805532455,
-0.009145821444690228,
0.025057362392544746,
-0.0805431678891182,
-0.0030197924934327602,
0.01273614726960659,
-0.022579288110136986,
0.01939813233911991,
-0.01182559970766306,
-0.01644749566912651,
0.01558305136859417,
0.01577899232506752,
-0.025587555021047592,
0.015041332691907883,
0.00560448132455349,
0.014361303299665451,
0.023167109116911888,
0.0041723852045834064,
-0.02186468057334423,
0.009779747575521469,
-0.019559495151042938,
-0.02290201373398304,
-0.019813066348433495,
0.0007110055303201079,
-0.014499614015221596,
-0.03259531781077385,
0.06694257259368896,
-0.013646695762872696,
0.0018744035623967648,
-0.013623643666505814,
-0.041009243577718735,
-0.03296414762735367,
-0.038243021816015244,
0.027961894869804382,
0.026924561709165573,
-0.03851964324712753,
-0.011370325461030006,
0.025495346635580063,
-0.019536443054676056,
0.026163849979639053,
0.0011266592191532254,
-0.027247287333011627,
-0.03289499133825302,
-0.02063140645623207,
0.027800532057881355,
0.04040989279747009,
0.012182903476059437,
-0.002237470354884863,
-0.0016064258525148034,
-0.03400148078799248,
-0.015928829088807106,
0.01682785153388977,
-0.00788949616253376,
-0.02195688709616661,
0.020746665075421333,
-0.029114486649632454,
-0.010551984421908855,
-0.006638932973146439,
-0.011762206442654133,
-0.06062636896967888,
0.03978749364614487,
0.013393125496804714,
-0.00007734976679785177,
-0.013012769632041454,
-0.0028944481164216995,
0.03287193924188614,
-0.021449746564030647,
-0.013243287801742554,
-0.006137555465102196,
-0.020366309210658073,
0.010154340416193008,
-0.03441641479730606,
0.02508041448891163,
0.025103464722633362,
0.021161599084734917,
-0.022279614582657814,
0.0081315403804183,
0.005339385010302067,
0.025034310296177864,
-0.0006739064701832831,
-0.01596340723335743,
-0.02376645803451538,
-0.009964162483811378,
0.005492103286087513,
-0.0355459526181221,
-0.04336053133010864,
0.018983198329806328,
0.02261386625468731,
-0.008817332796752453,
0.03556900471448898,
-0.0021553479600697756,
-0.014856917783617973,
0.019213717430830002,
-0.027616117149591446,
-0.05311146378517151,
0.020170370116829872,
0.0162630807608366,
0.02909143641591072,
-0.006932843942195177,
0.011283881030976772,
0.002769103506579995,
0.0435449443757534,
-0.020170370116829872,
0.030428443104028702,
-0.05103679746389389,
0.07063087075948715,
0.004809192381799221,
0.003091829363256693,
-0.01984764263033867,
-0.024757687002420425,
-0.02262539230287075,
0.033102456480264664,
0.005765844136476517,
0.008292903192341328,
0.004691051784902811,
0.028399880975484848,
-0.030728116631507874,
0.018867939710617065,
-0.035315435379743576,
0.001184288877993822,
0.013808058574795723,
0.010154340416193008,
-0.04257676750421524,
0.013600591570138931,
0.04292254522442818,
-0.039372559636831284,
-0.007647451478987932,
0.003051488660275936,
0.015421688556671143,
-0.0038150812033563852,
0.037390101701021194,
-0.003993733320385218,
0.01766924373805523,
-0.01288598496466875,
0.01919066533446312,
-0.012205954641103745,
0.0008630036609247327,
-0.004132044035941362,
-0.010799791663885117,
-0.03176544979214668,
0.018660472705960274,
0.0532497763633728,
0.026117747649550438,
0.00893835537135601,
-0.010471303015947342,
-0.021507376804947853,
0.001859996234998107,
0.015191169455647469,
0.007872207090258598,
-0.024826843291521072,
0.015179643407464027,
-0.03561510890722275,
-0.0009271166054531932,
-0.024365806952118874,
0.002442055381834507,
0.005255822092294693,
0.03722874075174332,
0.017530933022499084,
0.013704325072467327,
0.0007052425644360483,
-0.016216976568102837,
-0.012586310505867004,
-0.005503629334270954,
0.014188414439558983,
0.019040828570723534,
-0.039118990302085876,
-0.012367317453026772,
0.021495850756764412,
0.0042184884659945965,
-0.013715851120650768,
0.02346678450703621,
0.0022590814623981714,
-0.009485836140811443,
0.00047436385648325086,
-0.07118411362171173,
0.0023642554879188538,
-0.038243021816015244,
-0.016205450519919395,
0.011796784587204456,
-0.020884977653622627,
-0.0005093018407933414,
-0.004814955405890942,
-0.007751184981316328,
-0.0016827851068228483,
0.04133196920156479,
0.016182398423552513,
0.0575835220515728,
0.030820325016975403,
0.001002755481749773,
-0.016804799437522888,
-0.00036612822441384196,
0.006621643900871277,
-0.031212205067276955,
-0.02480379119515419,
-0.029437214136123657,
-0.015122014097869396,
0.03990275412797928,
0.03727484121918678,
-0.03439336270093918,
-0.024688532575964928,
0.00916887354105711,
-0.034439463168382645,
-0.022556236013770103,
-0.03450861945748329,
0.022648442536592484,
0.04398293048143387,
-0.029137538745999336,
-0.03079727292060852,
0.049284856766462326,
0.015698309987783432,
-0.012955140322446823,
0.03204207122325897,
0.01230968814343214,
-0.026463525369763374,
0.03951087221503258,
-0.019317450001835823,
0.06532894819974899,
0.00916311051696539,
-0.00817188061773777,
0.033886220306158066,
0.0026682517491281033,
0.00878851767629385,
-0.007226755376905203,
-0.029137538745999336,
-0.0274778064340353,
0.015986459329724312,
0.0011461091926321387,
0.025034310296177864,
0.0030658962205052376,
0.012482577003538609,
0.0030831850599497557,
-0.016862429678440094,
0.017231257632374763,
0.01188322901725769,
0.01145100686699152,
0.03199596703052521,
-0.012194428592920303,
0.022095199674367905,
0.005486340261995792,
0.013404651544988155,
-0.026740146800875664,
0.008413925766944885,
0.016193924471735954,
0.01928287371993065,
0.01871810294687748,
-0.02680930308997631,
-0.028768708929419518,
-0.0188218355178833,
-0.0004145731218159199,
0.014441984705626965,
-0.013289391994476318,
0.019213717430830002,
0.006673510652035475,
-0.04054820537567139,
-0.0008983018342405558,
0.01984764263033867,
0.044144295156002045,
0.010436725802719593,
-0.021518902853131294,
0.006333495955914259,
0.003918814472854137,
0.006316206883639097,
-0.016516651958227158,
-0.0026019776705652475,
-0.01976696215569973,
-0.014879969879984856,
0.02365119941532612,
-0.0029535184148699045,
0.02299422025680542,
-0.012643939815461636,
-0.01804959960281849,
0.023213213309645653,
0.008327481336891651,
-0.02565670944750309,
-0.009860428981482983,
-0.043867673724889755,
-0.03732094541192055,
-0.011664236895740032,
-0.01919066533446312,
-0.0028699554968625307,
0.011110992170870304,
-0.011145569384098053,
-0.04476669430732727,
0.01816485822200775,
0.003593207336962223,
-0.015940355136990547,
-0.028192413970828056,
0.0440751388669014,
0.005348029546439648,
-0.00013596989447250962,
-0.04492805525660515,
0.021242279559373856,
0.0013643814017996192,
-0.004011021926999092,
0.030912531539797783,
-0.03487744927406311,
-0.03460082784295082,
0.0019565257243812084,
-0.02291353978216648,
-0.014430458657443523,
-0.002973688766360283,
-0.017427198588848114,
0.001903218450024724,
-0.022279614582657814,
0.043775465339422226,
0.04096313938498497,
-0.009756695479154587,
-0.0129205621778965,
-0.015709836035966873,
-0.02241792529821396,
-0.03277973085641861,
0.007797288708388805,
0.007543717976659536,
-0.010557747446000576,
0.027316443622112274,
0.020977184176445007,
-0.016412917524576187,
0.016078665852546692,
-0.0279388427734375,
0.02431970275938511,
-0.012989717535674572,
0.029598576948046684,
0.007987466640770435,
-0.004483584780246019,
-0.005595836788415909,
0.0016856666188687086,
0.01692005805671215,
0.0003994453581981361,
-0.033125508576631546,
0.0010186036815866828,
-0.023074902594089508,
-0.026117747649550438,
-0.004740037024021149,
-0.014568769372999668,
0.008765466511249542,
0.010004503652453423,
-0.025725865736603737,
-0.002313829492777586,
0.007993229664862156,
0.012909036129713058,
-0.022498605772852898,
0.011554740369319916,
0.014511140063405037,
0.01372737716883421,
0.0063392589800059795,
-0.007843391969799995,
0.025795020163059235,
0.027293391525745392,
-0.004091703332960606,
-0.040801774710416794,
-0.018107227981090546,
-0.018579792231321335,
-0.001465953653678298,
0.043752413243055344,
0.005445999559015036,
-0.038634900003671646,
0.037482310086488724,
0.04859330132603645,
0.009670251049101353,
-0.0029030924197286367,
-0.010240784846246243,
0.0015920184087008238,
-0.045481301844120026,
-0.0008168999338522553,
0.04306085780262947,
0.027224235236644745,
0.012805302627384663,
-0.014914547093212605,
0.005863814614713192,
-0.026947613805532455,
-0.007901022210717201,
0.019813066348433495,
-0.015352532267570496,
-0.002066022017970681,
-0.02320168726146221,
-0.027016768231987953,
-0.0006476129055954516,
0.005584310740232468,
-0.009814325720071793,
0.04017937555909157,
0.021737895905971527,
0.007468799594789743,
0.035200174897909164,
-0.004330866504460573,
0.007486088667064905,
0.012229006737470627,
-0.040801774710416794,
-0.016320711001753807,
0.03158103674650192,
-0.018314694985747337,
-0.0257719699293375,
-0.004979199729859829,
0.02310948073863983,
-0.018648946657776833,
0.004036955535411835,
-0.011756443418562412,
-0.013704325072467327,
0.00510886637493968,
0.012586310505867004,
-0.008385110646486282,
0.0032445481047034264,
-0.004353918135166168,
0.031004739925265312,
0.000917031429708004,
-0.025841124355793,
-0.00024438565014861524,
0.0034664219710975885,
-0.012482577003538609,
0.008702073246240616,
-0.013012769632041454,
0.024204444140195847,
0.031004739925265312,
0.0035471036098897457,
-0.03759756684303284,
0.033770959824323654,
-0.04684136062860489,
-0.0037689777091145515,
0.0061778961680829525,
0.03400148078799248,
0.044236499816179276,
0.00511174788698554,
-0.030912531539797783,
0.00954922940582037,
-0.0027460516430437565,
-0.011243539862334728,
-0.007872207090258598,
0.017530933022499084,
-0.030543701723217964,
0.007486088667064905,
0.004296288825571537,
0.0308894794434309,
0.010551984421908855,
-0.0253800880163908,
-0.0052414145320653915,
-0.007399644237011671,
0.011272354982793331,
-0.01807265169918537,
-0.021530428901314735,
0.0031696294900029898,
0.018695050850510597,
-0.008413925766944885,
0.023397628217935562,
-0.032825835049152374,
0.017530933022499084,
0.036537181586027145,
0.01996290311217308,
-0.004437481053173542,
0.011059124954044819,
-0.004008140414953232,
-0.013104977086186409,
-0.0010013147257268429,
0.03591478243470192,
-0.018038073554635048,
0.01585967279970646,
0.02061988040804863,
-0.00836782157421112,
-0.013266339898109436,
-0.004935977514833212,
-0.027685273438692093,
0.0025760442949831486,
-0.014730132184922695,
-0.02805410325527191,
0.00878851767629385,
0.007549481000751257,
0.021161599084734917,
0.01026959903538227,
0.0009797036182135344,
0.01871810294687748,
0.013600591570138931,
-0.0046651181764900684,
-0.027155080810189247,
-0.022221984341740608,
0.034347258508205414,
-0.0118371257558465,
0.036906011402606964,
-0.002565959235653281,
-0.0012145444052293897,
0.017888236790895462,
0.008915303274989128,
-0.011041836813092232,
0.029667731374502182,
-0.01293208822607994,
-0.03762061893939972,
-0.02053919807076454,
0.012044591829180717,
0.0023339998442679644,
-0.019732384011149406,
-0.0017663480248302221,
0.011814073659479618,
0.011082177050411701,
0.011814073659479618,
0.03983359783887863,
-0.02614079788327217,
-0.024642428383231163,
-0.003420318244025111,
-0.00591856287792325,
0.022164354100823402,
0.0006778684910386801,
0.020700562745332718,
-0.038911525160074234,
-0.02927585132420063,
0.004967673681676388,
0.006517910864204168,
-0.020884977653622627,
0.02252165786921978,
-0.02946026436984539,
-0.01987069472670555,
-0.004895636811852455,
-0.02660183608531952,
-0.033863168209791183,
-0.042046576738357544,
-0.006316206883639097,
-0.009612621739506721,
-0.012424947693943977,
-0.009843139909207821,
-0.04331442713737488,
0.014810814522206783,
0.001859996234998107,
-0.014914547093212605,
0.007434221915900707,
0.022198932245373726,
0.028238516300916672,
-0.009214977733790874,
-0.01664343662559986,
-0.009428206831216812,
0.007157599553465843,
-0.0190869327634573,
-0.010938103310763836,
-0.004581555258482695,
0.005751436576247215,
0.00038539813249371946,
0.008027806878089905,
0.024550221860408783,
0.02586417645215988,
-0.008385110646486282,
0.014050102792680264,
0.028077153488993645,
-0.022291138768196106,
0.02034325897693634,
0.002725881291553378,
-0.005878221709281206,
-0.0017375332536175847,
-0.01804959960281849,
-0.021714843809604645,
-0.0024348518345505,
-0.019029302522540092,
-0.019547969102859497,
0.004619014449417591,
0.007313199806958437,
0.004760207142680883,
-0.02090802788734436,
0.00553532550111413,
-0.03277973085641861,
-0.0004322222084738314,
-0.013439228758215904,
0.001841266523115337,
-0.019052354618906975,
-0.0015185406664386392,
-0.01288598496466875,
0.001388153643347323,
-0.009335999377071857,
-0.01643596962094307,
-0.0024362923577427864,
-0.015559999272227287,
-0.008673259057104588,
0.008246799930930138,
-0.01683937758207321,
-0.009779747575521469,
-0.006206710822880268,
-0.005353792104870081,
0.0017951629124581814,
-0.009566518478095531,
0.0025875703431665897,
-0.006442992482334375,
0.012321214191615582,
-0.011197436600923538,
-0.023996977135539055,
0.005373962689191103,
0.003933222033083439,
-0.0044922293163836,
0.013992473483085632,
-0.02261386625468731,
-0.013992473483085632,
-0.01003331784158945,
-0.017888236790895462,
-0.020562250167131424,
0.005056999623775482,
0.00936481449753046,
-0.0014119258848950267,
-0.03125831112265587,
0.00150845549069345,
0.009716355241835117,
-0.013012769632041454,
0.007958651520311832,
-0.02830767259001732,
-0.03289499133825302,
-0.0006947971996851265,
0.009578043594956398,
0.0054546440951526165,
-0.011157095432281494,
0.016286132857203484,
-0.02244097739458084,
0.019686279818415642,
-0.002338322112336755,
0.019144561141729355,
0.013058873824775219,
0.006425703410059214,
-0.0005600879085250199,
-0.018660472705960274,
-0.017219731584191322,
-0.016309184953570366,
-0.015536947175860405,
0.029437214136123657,
0.015825094655156136,
-0.010926577262580395,
-0.022659968584775925,
-0.00022439536405727267,
0.017461776733398438,
0.016113243997097015,
-0.01497217733412981,
-0.0001537990610813722,
0.022268088534474373,
-0.00689250323921442,
-0.002017037011682987,
0.06431466341018677,
-0.023812562227249146,
-0.039003729820251465,
-0.03584562614560127,
0.005558377597481012,
-0.02385866641998291,
-0.03861185163259506,
0.0012628091499209404,
0.005976192187517881,
-0.02376645803451538,
0.006298918277025223,
0.007353540509939194,
0.000013777083040622529,
-0.005480577703565359,
-0.030290132388472557,
-0.0141653623431921,
0.023789510130882263,
-0.001697192550636828,
-0.001861436991021037,
0.03363265097141266,
0.008068148046731949,
-0.002578925807029009,
0.029990456998348236,
-0.026348264887928963,
0.02231419086456299,
-0.02034325897693634,
-0.019444236531853676,
0.013439228758215904,
-0.014361303299665451,
-0.033494338393211365,
-0.00788373313844204,
0.017600087448954582,
0.012782251462340355,
0.011577792465686798,
0.0002645560016389936,
0.01807265169918537,
-0.0007873647846281528,
-0.034070637077093124,
0.0003598249750211835,
0.05182056128978729,
-0.02519567310810089,
-0.0007182092522270977,
0.01957102119922638,
-0.0072037032805383205,
0.023812562227249146,
0.013323970139026642,
-0.014430458657443523,
0.010373332537710667,
0.03155798465013504,
0.004944622050970793,
-0.018418429419398308,
-0.023074902594089508,
-0.009583806619048119,
0.11636574566364288,
-0.011410665698349476,
-0.005385488737374544,
0.0013672629138454795,
-0.01682785153388977,
-0.01604408770799637,
0.043014753609895706,
-0.008431214839220047,
-0.004621895961463451,
0.0035009998828172684,
0.020470043644309044,
0.01901777647435665,
0.03536153957247734,
0.015997983515262604,
0.007468799594789743,
-0.027500858530402184,
-0.005002251826226711,
0.03517712280154228,
-0.005189547780901194,
-0.026394369080662727,
-0.004085940308868885,
0.005809066351503134,
0.01576746627688408,
-0.0025328220799565315,
-0.013854161836206913,
-0.04492805525660515,
0.001783636980690062,
-0.006915555335581303,
-0.02680930308997631,
-0.031396619975566864,
-0.0012181461788713932,
-0.010039080865681171,
0.023535938933491707,
-0.031235257163643837,
0.02851513959467411,
-0.0010481388308107853,
0.010085185058414936,
0.006834873929619789,
-0.0015127777587622404,
0.007353540509939194,
-0.02327084355056286,
-0.02450411766767502,
0.020596828311681747,
-0.04693356901407242,
0.0188218355178833,
0.034162841737270355,
-0.01806112565100193,
-0.005895510781556368,
0.020596828311681747,
-0.016170872375369072,
0.0018383851274847984,
-0.019432710483670235,
0.02773137576878071,
-0.005590073764324188,
-0.033609598875045776,
-0.04068651795387268,
-0.005748555064201355,
-0.06731140613555908,
-0.0005154249956831336,
-0.005621769931167364,
-0.01244799979031086,
0.03238784894347191,
0.0291836429387331,
-0.02261386625468731,
0.017542459070682526
] | 2025-01-08 | 130 | 39768494 | [
"hematological conditions",
"cancer cells",
"chimeric antigen receptor T cells",
"sickle cell disease",
"acute myeloid leukemias",
"critical medical conditions",
"acute promyelocytic leukemia",
"Sickle cell crisis",
"hematological malignancies",
"cytokine release syndrome",
"acute kidney injury",
"Hematological emergencies",
"severe hemolysis",
"rapid destruction",
"Tumor lysis syndrome",
"adequate diagnostic strategies",
"mild allergic responses",
"Disseminated intravascular coagulation",
"management approaches",
"excessive coagulation",
"patient outcomes",
"cancers",
"early intervention",
"prompt management",
"acute pain",
"multiple myeloma",
"electrolyte imbalances",
"immediate attention",
"Acute transfusion reactions",
"bispecific antibodies"
] | [
"CAR-T complications",
"DIC",
"PTT",
"TLS",
"emergencies",
"hypercalcemia",
"hyperleukocytosis",
"septic shock",
"sickle crisis",
"transfusion reactions"
] | 0 | 10.3390/jcm13247572
10.1055/a-1049-0647
10.1001/jama.2022.18331
10.7861/clinmed.2023-0227
10.1007/s12020-017-1353-y
10.7759/cureus.35783
10.1002/cam4.3594
10.1002/jbmr.2022
10.4065/78.1.21
10.1359/JBMR.040314
10.1001/archsurg.1980.01380060012004
10.1359/jbmr.2003.18.3.579
10.1159/000106100
10.3322/caac.21727
10.2147/CIA.S14566
10.3390/cells9102310
10.1188/17.CJON.E267-E271
10.2147/IJGM.S321787
10.3390/jcm12062188
10.1002/hon.2292
10.1182/blood.V97.7.2121
10.1111/j.1537-2995.2007.01406.x
10.1111/trf.15994
10.3390/cancers16010058
10.3390/cancers14092186
10.1111/j.1600-0609.2005.00421.x
10.1016/j.blre.2012.01.003
10.1148/radiology.165.3.3479813
10.1038/s41375-020-0783-3
10.1002/jca.21705
10.1111/bjh.13189
10.1182/bloodadvances.2022007126
10.1182/blood-2019-01-894980
10.1182/blood.V84.11.3843.bloodjournal84113843
10.3109/10428194.2016.1142083
10.1182/blood-2014-10-551507
10.1159/000509934
10.1111/j.1365-2141.2004.05094.x
10.1080/20009666.2020.1761185
10.3324/haematol.11575
10.1002/ajh.2830470212
10.1155/2017/9684909
10.1016/0002-9343(93)90174-N
10.1182/blood.V120.21.238.238
10.1080/1042819021000054661
10.1200/JCO.2009.26.8896
10.1093/annonc/mdv317
10.1681/ASN.2005050572
10.1001/jama.1978.03280500068025
10.1007/978-3-030-90684-9_21
10.1111/bjh.13403
10.1016/j.jemermed.2019.08.009
10.1093/cid/cir073
10.1093/cid/cir492
10.3390/jcm12020578
10.3389/fonc.2023.1117815
10.3389/fonc.2023.1157610
10.1002/cncr.35005
10.3390/jcm12093188
10.1177/20499361221138346
10.1186/s12879-023-08218-8
10.4103/0974-2727.163126
10.3390/hematolrep14020011
10.3390/jcm11102847
10.4081/hr.2021.9329
10.1002/9781119665885.ch8
10.1159/000492950
10.1182/blood-2018-10-860809
10.1046/j.1537-2995.2001.41121493.x
10.1016/j.emc.2018.04.009
10.1097/01.NAJ.0000532808.81713.fc
10.1055/s-0042-1756300
10.1111/jth.15074
10.1016/j.bcmd.2019.102393
10.1097/CCO.0000000000000402
10.1055/s-0039-1693478
10.1177/1076029618806424
10.1161/JAHA.118.010942
10.3390/jcm11030623
10.1055/s-0037-1616068
10.1111/j.1600-0609.2006.00711.x
10.1097/01.CCM.0000202209.42491.38
10.1111/j.1365-2141.2009.07600.x
10.1016/j.thromres.2009.08.017
10.1016/j.thromres.2011.08.028
10.1111/jth.12155
10.1111/j.1538-7836.2004.00787.x
10.1016/0049-3848(93)90109-2
10.1182/blood.2020004919
10.1182/blood-2016-10-709857
10.3324/haematol.2011.051433
10.3324/haematol.2022.280702
10.1111/j.1365-2141.2012.09167.x
10.1002/ajh.24339
10.1056/NEJMoa1505533
10.1056/NEJMoa1806311
10.7759/cureus.56389
10.1111/ejh.13430
10.1097/MS9.0000000000000696
10.1016/j.hoc.2016.01.011
10.1097/MS9.0000000000002478
10.1017/CBO9780511544835.056
10.1016/j.chest.2015.12.016
10.14740/jocmr4841
10.1177/1076029609352661
10.1097/AJP.0000000000000036
10.1097/MOH.0b013e32834521dd
10.3389/fimmu.2023.1188049
10.1007/s00277-024-05725-9
10.1038/s41573-024-00896-6
10.3389/fimmu.2023.1195734
10.1186/s40425-018-0343-9
10.1038/s41577-021-00547-6
10.1093/brain/awae340
10.1016/j.bbmt.2018.12.758
10.3389/fimmu.2021.611366
10.1016/j.jtct.2022.03.006
10.1016/j.bbmt.2020.07.031
10.1136/esmoopen-2020-000746
10.1007/s11899-023-00702-x
10.2147/BLCTT.S409443
10.1182/BLOOD.2022017414
10.3390/jcm13144273
10.1080/14656566.2023.2228695
10.3390/cancers16010154
10.1002/ajh.24726
10.7861/clinmedicine.17-3-258
10.7861/clinmed.2019-0324
10.1016/j.amjmed.2005.01.026
10.1002/hem3.143 | [
"Duminuco",
"Del Fabro",
"De Luca",
"Leotta",
"Limoli",
"Longo",
"Nardo",
"Santuccio",
"Petronaci",
"Stanzione",
"Di Raimondo",
"Palumbo"
] | [
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Faculty of Medicine and Surgery, \"Kore\" University of Enna, 94100 Enna, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy.",
"Hematology Unit with BMT, A.O.U. Policlinico \"G.Rodolico-San Marco\", 95123 Catania, Italy."
] | [
"39768494",
"31826272",
"36282253",
"37775175",
"28613465",
"28667379",
"37025710",
"33145966",
"23787729",
"12528874",
"15176993",
"7387355",
"12619944",
"17641550",
"35653456",
"22977302",
"33080779",
"29149122",
"34285568",
"36983189",
"27018197",
"11264180",
"17880610",
"32776542",
"38201486",
"35565314",
"15876254",
"22364832",
"3479813",
"32132655",
"1774952",
"31180581",
"25312977",
"36075018",
"30803991",
"7949141",
"26849624",
"25778528",
"32998135",
"15384972",
"32850076",
"18166787",
"30085527",
"8092128",
"29230244",
"8430709",
"0",
"12691145",
"20713865",
"26216382",
"16251237",
"274588",
"25876990",
"31635928",
"21258094",
"21890754",
"36675507",
"36865808",
"37064138",
"37658645",
"37176628",
"36451936",
"37055745",
"26417163",
"35466175",
"35628973",
"35070221",
"30498407",
"30808638",
"11778062",
"30037447",
"29664740",
"36100234",
"33433069",
"31918382",
"28841588",
"31370070",
"30296833",
"30712441",
"35160072",
"11816725",
"16856920",
"16521260",
"19222477",
"19782389",
"21930293",
"23379279",
"15304040",
"8128454",
"32321172",
"28416507",
"21993669",
"35511612",
"22624596",
"26910131",
"26863353",
"30625070",
"38633967",
"32301178",
"37228913",
"27112998",
"39359808",
"26836899",
"36755761",
"20530056",
"24322996",
"21372708",
"37256141",
"38609726",
"38448606",
"37809082",
"29907163",
"34002066",
"39442000",
"30592986",
"33708205",
"35288347",
"32736009",
"32839196",
"37395943",
"38146420",
"36989488",
"39064314",
"37341682",
"38201581",
"28321923",
"28572228",
"32675141",
"15866259",
"39131900"
] | [] | 6.091089 | 4.105611 |
39767716 | 65 | Updates on Chimeric Antigen Receptor T-Cells in Large B-Cell Lymphoma. | CD19-targeting chimeric antigen receptor (CAR) T-cells have changed the treatment paradigm of patients with large B-cell lymphoma (LBCL). Three CAR T-cells were approved by the Food and Drug Administration (FDA) for patients with relapsed and/or refractory (R/R) LBCL in the third-line setting: tisagenlecleucel (tisa-cel), axicabtagene ciloleucel (axi-cel), and lisocabtagene maraleucel (liso-cel), with an ORR ranging from 58% to 82%. More recently, axi-cel and liso-cel were approved as second-line treatments for patients with R/R disease up to 12 months after the completion of first-line chemo-immunotherapy. The safety profile was acceptable with cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome being the two most frequent acute adverse events. Potential long-term toxicities of CD19-targeting CAR T-cells have also been described. Overall, 30% to 40% of patients are cured with a single infusion of CAR T-cells. However, 60% to 70% of patients relapse after being treated with CAR T-cells and have a dismal prognosis. The advent of bispecific antibodies (BsAb) offers an additional treatment modality for patients with R/R LBCL. The aim of this review is to describe the clinical efficacy of the three CAR T-cells, as well as their safety profile. We also compare these three CAR T-cells in terms of their efficacy and safety profile as well as evaluating the place of CAR T-cells and BsAb in the treatment arsenal of patients with R/R LBCL. | [
0.009968819096684456,
0.004878293722867966,
0.052099812775850296,
0.06117119640111923,
-0.0013097717892378569,
0.0030879690311849117,
-0.009059255011379719,
-0.006118332501500845,
0.04855857789516449,
-0.015389818698167801,
0.0035836813040077686,
-0.05898824334144592,
-0.06907833367586136,
0.014140685088932514,
0.019876999780535698,
-0.031483035534620285,
0.04608456417918205,
-0.03837146237492561,
-0.009010745212435722,
0.02075018174946308,
-0.0036594781558960676,
0.01684512197971344,
-0.005687805358320475,
-0.007591825444251299,
-0.022775476798415184,
-0.02961539663374424,
0.018009362742304802,
-0.005029887892305851,
0.0038322953041642904,
-0.01589917577803135,
0.007858631201088428,
-0.018021490424871445,
-0.022739093750715256,
-0.0058697182685136795,
-0.014164939522743225,
0.021223153918981552,
0.06665283441543579,
0.01616598106920719,
0.013194738887250423,
-0.018445953726768494,
0.016056831926107407,
0.01542620174586773,
0.015377691946923733,
0.05971589311957359,
-0.05413723737001419,
-0.009768715128302574,
0.017427241429686546,
-0.03875954449176788,
0.02464311383664608,
-0.015050248242914677,
-0.016178106889128685,
0.009695949964225292,
-0.03318088501691818,
0.046957746148109436,
-0.05714486166834831,
0.047903694212436676,
-0.02176889218389988,
0.020022530108690262,
0.04373182728886604,
-0.03664935752749443,
0.011151252314448357,
-0.009902117773890495,
0.016408530995249748,
-0.03878379985690117,
-0.05971589311957359,
0.011515077203512192,
-0.04846155643463135,
-0.024194397032260895,
0.01156965084373951,
0.009635312482714653,
-0.0046296794898808,
0.003198632737621665,
0.0046630301512777805,
0.0258801206946373,
0.01642065867781639,
0.004623615648597479,
0.022302504628896713,
0.023333342745900154,
0.024837154895067215,
-0.00850745290517807,
0.024764390662312508,
0.027869034558534622,
-0.010314453393220901,
-0.03250174596905708,
0.011369546875357628,
0.010641896165907383,
0.01740298606455326,
-0.021453578025102615,
-0.0316285640001297,
0.013813242316246033,
-0.04089398682117462,
-0.014007282443344593,
-0.0488738939166069,
0.040263354778289795,
-0.028014564886689186,
0.0037413390818983316,
-0.0128551684319973,
-0.042276524007320404,
0.04314970597624779,
0.025298001244664192,
0.03793487325310707,
0.010065838694572449,
0.01435898058116436,
-0.01418919488787651,
0.0455024428665638,
0.033496201038360596,
-0.039875276386737823,
-0.007094597443938255,
0.049819838255643845,
-0.030464323237538338,
0.05884271115064621,
-0.0050420151092112064,
-0.001011889660730958,
0.03417534381151199,
-0.02048337645828724,
-0.0382259339094162,
0.0038626142777502537,
-0.013910261914134026,
-0.0006529910024255514,
0.0056271678768098354,
-0.02404886670410633,
0.03262301906943321,
0.0188582893460989,
-0.034345127642154694,
-0.0035836813040077686,
-0.025395020842552185,
0.11302845925092697,
-0.04703051224350929,
-0.011133060790598392,
-0.06432434916496277,
0.023818442597985268,
0.005524083971977234,
0.04152461886405945,
-0.0004646354936994612,
-0.10303538292646408,
0.017778940498828888,
-0.006166842300444841,
-0.024497585371136665,
-0.06573114544153214,
-0.0037474026903510094,
0.009665630757808685,
-0.011891030706465244,
-0.027456698939204216,
-0.015838537365198135,
-0.035630643367767334,
-0.04225226864218712,
-0.012697510421276093,
0.010320517234504223,
-0.01813063770532608,
0.021671872586011887,
-0.059036754071712494,
0.053167033940553665,
0.0504019595682621,
0.003468469949439168,
-0.01774255745112896,
-0.07795567810535431,
-0.01791234314441681,
0.07320169359445572,
-0.03647956997156143,
-0.043562039732933044,
0.006858110893517733,
0.011029976420104504,
-0.031434524804353714,
-0.02215697430074215,
0.010356899350881577,
0.005548338871449232,
-0.013934517279267311,
0.030803892761468887,
-0.07043661922216415,
0.00850745290517807,
-0.011387738399207592,
-0.025734590366482735,
-0.05370064452290535,
-0.03470895439386368,
-0.05418574437499046,
-0.0024482423905283213,
0.0385655052959919,
0.04072420299053192,
-0.014625785872340202,
-0.03257451206445694,
0.008076926693320274,
-0.004138515330851078,
0.019767852500081062,
-0.015583859756588936,
-0.05481637641787529,
0.020374229177832603,
-0.03468469902873039,
0.01688150316476822,
-0.03466044366359711,
-0.02078656479716301,
-0.005666582379490137,
0.006142587400972843,
0.027796268463134766,
0.010387218557298183,
0.01380111463367939,
-0.009471590630710125,
0.02374567836523056,
0.038080401718616486,
-0.03553362563252449,
-0.02893625572323799,
0.04407139867544174,
-0.025055449455976486,
-0.023466745391488075,
0.0022799731232225895,
-0.02298164553940296,
0.0012688414426520467,
0.007137043867260218,
0.015207906253635883,
-0.038638267666101456,
-0.045575208961963654,
0.036528080701828,
-0.019743597134947777,
-0.03427236154675484,
0.03155579790472984,
-0.03107069805264473,
-0.0023845729883760214,
-0.02014380507171154,
0.04737007990479469,
0.025443531572818756,
0.029300080612301826,
0.027966054156422615,
-0.01149082276970148,
-0.0015674815513193607,
0.02117464505136013,
-0.027505207806825638,
0.014734933152794838,
0.009053191170096397,
-0.013716221787035465,
-0.014286215417087078,
-0.02001040242612362,
0.014492383226752281,
0.014274087734520435,
0.017463624477386475,
-0.02048337645828724,
-0.01450450997799635,
0.004423511680215597,
-0.002721111522987485,
0.02636522240936756,
0.07111576199531555,
-0.024885665625333786,
0.007124916184693575,
0.01667533628642559,
0.01576577126979828,
-0.017281711101531982,
0.011727308854460716,
-0.010150731541216373,
0.023151429370045662,
-0.06408180296421051,
0.030100496485829353,
0.008925852365791798,
-0.019561685621738434,
0.02125953696668148,
-0.001975269289687276,
-0.0377165786921978,
0.011696990579366684,
0.038468483835458755,
0.02949412167072296,
-0.03691616281867027,
-0.003895964939147234,
-0.021101878955960274,
0.0056271678768098354,
0.008004161529242992,
-0.02022869884967804,
-0.03970549255609512,
-0.07562719285488129,
0.02112613432109356,
-0.0029651778750121593,
0.018239784985780716,
0.011078487150371075,
-0.002370929578319192,
0.00691268453374505,
0.0021875009406358004,
0.037231478840112686,
-0.01817914843559265,
-0.019573813304305077,
0.010763171128928661,
0.021720383316278458,
0.01093295682221651,
-0.006003120914101601,
0.04739433526992798,
0.018918925896286964,
0.0050420151092112064,
-0.023733550682663918,
-0.03912337124347687,
0.00023307571245823056,
-0.009265422821044922,
-0.007876822724938393,
-0.031046444550156593,
-0.004520532209426165,
-0.015498966909945011,
0.018142765387892723,
-0.003201664425432682,
-0.023454617708921432,
-0.05011089891195297,
-0.02369716763496399,
0.00018020732386503369,
0.008095117285847664,
-0.02203569933772087,
-0.04683646932244301,
0.029688160866498947,
-0.03895358368754387,
0.03614000231027603,
-0.02078656479716301,
-0.03429661691188812,
0.021829530596733093,
0.027796268463134766,
-0.014880463480949402,
-0.018482336774468422,
0.005842431448400021,
0.06626475602388382,
0.028863491490483284,
0.02692308835685253,
0.01497748401015997,
-0.017330221831798553,
0.01594768464565277,
-0.01902807503938675,
-0.021962933242321014,
-0.05622316896915436,
0.014480255544185638,
-0.02592863142490387,
0.007343211676925421,
-0.016699591651558876,
-0.007015768438577652,
0.019404027611017227,
-0.01163635216653347,
-0.03150729089975357,
0.010472111403942108,
-0.014237704686820507,
0.004796432796865702,
-0.03364173322916031,
0.04033612087368965,
-0.012612617574632168,
0.07494805753231049,
-0.010623704642057419,
-0.0010217432864010334,
-0.004180961288511753,
-0.015438329428434372,
-0.057629961520433426,
0.00600008899345994,
0.005045047029852867,
0.0055634984746575356,
0.03322939574718475,
-0.04615733027458191,
0.049092188477516174,
0.01380111463367939,
-0.0008178494172170758,
0.014456000179052353,
0.03322939574718475,
0.0008254291024059057,
0.007240127772092819,
0.009338187985122204,
0.005032919347286224,
0.007858631201088428,
-0.02871796116232872,
-0.013619201257824898,
0.046860724687576294,
-0.0372072234749794,
-0.012182090431451797,
0.013873879797756672,
0.019731469452381134,
0.011108805425465107,
0.036576591432094574,
-0.043659061193466187,
0.04113653674721718,
0.04504159837961197,
0.05617465823888779,
-0.012867295183241367,
0.011163379065692425,
-0.030197517946362495,
-0.028354134410619736,
0.01079955417662859,
-0.012091134674847126,
0.026632027700543404,
0.018324678763747215,
-0.001790324691683054,
0.009835416451096535,
0.026510752737522125,
0.024715879932045937,
0.0034351192880421877,
0.0191129669547081,
0.04040888696908951,
-0.032720040529966354,
-0.014686423353850842,
-0.007998097687959671,
-0.013704094104468822,
0.017463624477386475,
0.009896053932607174,
-0.008234583772718906,
-0.039365921169519424,
0.04307693988084793,
0.00662162434309721,
0.009022872895002365,
0.01628725603222847,
-0.009883926250040531,
0.0035958087537437677,
0.0688357874751091,
0.0006833098013885319,
0.09595291316509247,
0.04016633704304695,
0.015547476708889008,
-0.006870238576084375,
-0.03837146237492561,
-0.0035715538542717695,
-0.06233543902635574,
-0.005615040194243193,
-0.007525124121457338,
0.008307348936796188,
0.017584899440407753,
0.005369458347558975,
-0.02922731637954712,
-0.007767674513161182,
0.043950121849775314,
0.039535705000162125,
-0.009229040704667568,
0.035169798880815506,
-0.022872496396303177,
-0.040045060217380524,
0.03837146237492561,
0.0016902727074921131,
0.058697182685136795,
0.06553710252046585,
-0.045793503522872925,
0.018445953726768494,
-0.0573389008641243,
-0.0031561863142997026,
-0.01650555059313774,
0.04654540866613388,
0.012661127373576164,
-0.0016720814164727926,
-0.02507970482110977,
-0.000631009868811816,
0.06456690281629562,
-0.006548859179019928,
-0.023818442597985268,
0.005705996882170439,
0.05253640562295914,
-0.030925167724490166,
0.023151429370045662,
-0.04509010910987854,
0.016044704243540764,
-0.022278249263763428,
0.026243947446346283,
0.033277906477451324,
-0.014080047607421875,
0.03592170402407646,
-0.014916845597326756,
0.009641376323997974,
0.016275128349661827,
-0.04826751723885536,
-0.007100661285221577,
-0.044507987797260284,
-0.021829530596733093,
-0.01455302070826292,
0.003222887637093663,
-0.06340266019105911,
-0.023248450830578804,
0.028402645140886307,
-0.08610536903142929,
0.001904020202346146,
0.03201664611697197,
0.04504159837961197,
-0.04079696908593178,
0.040602926164865494,
-0.022739093750715256,
-0.013376651331782341,
0.05049898102879524,
0.016942141577601433,
0.005196641199290752,
0.012242728844285011,
-0.04111228138208389,
0.00867723859846592,
0.0049328673630952835,
-0.02541927620768547,
0.03337492793798447,
-0.0003594671725295484,
0.05971589311957359,
-0.0014530281769111753,
-0.005997057072818279,
0.020131677389144897,
0.022605691105127335,
-0.004669093992561102,
0.0321379192173481,
-0.021114006638526917,
-0.031264737248420715,
0.03376300632953644,
0.03441789373755455,
0.005117812193930149,
-0.008731812238693237,
-0.04846155643463135,
0.040991008281707764,
0.0055544027127325535,
0.012036561034619808,
0.042494818568229675,
-0.011472631245851517,
-0.016990652307868004,
-0.017475752159953117,
-0.019270624965429306,
-0.003104644361883402,
-0.014674295671284199,
0.004747922997921705,
0.01418919488787651,
0.04894666001200676,
0.02910604141652584,
0.02408524975180626,
0.03980251029133797,
0.052827462553977966,
-0.023248450830578804,
0.044556498527526855,
0.007349275518208742,
0.001875217305496335,
0.00288786506280303,
-0.03191962465643883,
0.03257451206445694,
-0.04530840367078781,
-0.02866945043206215,
-0.027844779193401337,
-0.06490647047758102,
-0.024194397032260895,
-0.013570691458880901,
-0.00600008899345994,
-0.015292799100279808,
-0.026292456313967705,
0.018664248287677765,
-0.0053937132470309734,
0.016093214973807335,
-0.006136523559689522,
-0.008725748397409916,
-0.028135839849710464,
-0.037013180553913116,
-0.0451628752052784,
0.007797993253916502,
-0.042494818568229675,
-0.019949765875935555,
0.015753645449876785,
-0.023721423000097275,
-0.006463966798037291,
-0.015753645449876785,
0.032040901482105255,
-0.01873701438307762,
-0.023539511486887932,
-0.021186772733926773,
-0.011527204886078835,
0.036115746945142746,
0.0045387232676148415,
0.00300004449672997,
0.007033959962427616,
0.012709638103842735,
-0.004793401341885328,
0.012952188029885292,
0.011533268727362156,
0.03960847109556198,
-0.034054066985845566,
0.010787426494061947,
-0.009568611159920692,
0.0183489341288805,
-0.0368676520884037,
-0.0039535705000162125,
-0.024885665625333786,
-0.00003519822348607704,
-0.019767852500081062,
-0.012733892537653446,
-0.017366604879498482,
0.00039300735807046294,
-0.024024611338973045,
0.008180010132491589,
0.00525121483951807,
-0.019440410658717155,
0.0022875529248267412,
-0.03051283210515976,
0.0389050729572773,
-0.019901255145668983,
0.017512135207653046,
0.0032077282667160034,
-0.029906457290053368,
0.0128551684319973,
-0.00433861929923296,
-0.0188582893460989,
0.014904718846082687,
-0.006585241761058569,
0.015244289301335812,
-0.044605009257793427,
-0.05855165049433708,
-0.036455314606428146,
0.024958429858088493,
-0.004581169690936804,
0.03320514038205147,
-0.045744992792606354,
-0.003116771811619401,
-0.0193676445633173,
0.02219335548579693,
0.01343728881329298,
-0.010951148346066475,
0.02704436331987381,
0.0225814376026392,
-0.05607764050364494,
0.02210846357047558,
0.051275141537189484,
0.005957642570137978,
-0.02134443074464798,
0.013522181659936905,
-0.008531708270311356,
-0.02455822192132473,
-0.024315671995282173,
-0.021696127951145172,
-0.018700631335377693,
0.03871103376150131,
-0.00856809038668871,
-0.022617818787693977,
-0.009089574217796326,
0.016954269260168076,
0.05520445853471756,
0.03485448285937309,
-0.007949587889015675,
-0.0017691015964373946,
0.03955996036529541,
0.025734590366482735,
-0.022726966068148613,
-0.018955308943986893,
0.024182269349694252,
-0.031701330095529556,
-0.03313237801194191,
0.0010831388644874096,
-0.007215872872620821,
0.009665630757808685,
0.01967083290219307,
-0.020289335399866104,
-0.02357589267194271,
-0.03177409619092941,
0.011387738399207592,
0.014601530507206917,
0.010654023848474026,
-0.007488742005079985,
0.005469510331749916,
0.048752617090940475,
-0.01576577126979828,
-0.025783101096749306,
0.0377165786921978,
0.015547476708889008,
0.001790324691683054,
0.024206524714827538,
-0.0023815410677343607,
0.020628906786441803,
0.0026877608615905046,
-0.06000695377588272,
0.02242377959191799,
-0.009865734726190567,
-0.011023912578821182,
-0.006151683162897825,
0.011345292441546917,
-0.004590264987200499,
-0.017948724329471588,
-0.053894687443971634,
0.03288982808589935,
0.010217432864010334,
0.021320175379514694,
-0.02524949051439762,
-0.004787337500602007,
0.020349973812699318,
0.06442137062549591,
0.0813513845205307,
-0.04208248481154442,
0.017681919038295746,
-0.007288637571036816,
-0.00854989979416132,
-0.003650382626801729,
0.009253295138478279,
0.009544355794787407,
-0.01714830845594406,
0.026607772335410118,
0.010902637615799904,
0.07514209300279617,
0.014419618062675,
0.0032046963460743427,
-0.03364173322916031,
-0.013340269215404987,
-0.0003399494744371623,
-0.01399515476077795,
-0.006360882893204689,
-0.05219683423638344,
0.0162387453019619,
0.003738307161256671,
0.010278070345520973,
-0.032720040529966354,
-0.05884271115064621,
0.007913204841315746,
-0.000100336255854927,
0.012903678230941296,
-0.022448034957051277,
0.0039171879179775715,
-0.001970721408724785,
-0.013012825511395931,
-0.013558563776314259,
-0.0224965438246727,
-0.0037049564998596907,
0.016602570191025734,
0.011660607531666756,
0.007676718290895224,
-0.03301110118627548,
-0.030997933819890022,
-0.003004592377692461,
0.03711020201444626,
0.005781793966889381,
0.03291407972574234,
-0.025831611827015877,
0.016081087291240692,
-0.010326581075787544,
-0.011988050304353237,
-0.04535691440105438,
0.015850665047764778,
0.0108238086104393,
-0.002323935506865382,
-0.007282574195414782,
-0.02854817546904087,
-0.015377691946923733,
0.00220266031101346,
0.005175417754799128,
-0.0007113546598702669,
0.029809437692165375,
0.0061031728982925415,
0.0068763019517064095,
-0.011703054420650005,
0.03250174596905708,
-0.028814980760216713,
-0.014916845597326756,
0.03708594664931297,
0.03757104650139809,
-0.051372162997722626,
0.04191269725561142,
-0.005648390855640173,
-0.012891550548374653,
0.00580604886636138,
-0.017245329916477203,
-0.03211366385221481,
-0.006779281888157129,
-0.021029114723205566,
0.02580735646188259,
-0.013898134231567383,
-0.023636531084775925,
-0.01679661124944687,
-0.0006905104964971542,
0.03286557272076607,
-0.027165638282895088,
-0.03415108844637871,
0.01343728881329298,
-0.0183489341288805,
0.004796432796865702,
0.034345127642154694,
-0.0005355056491680443,
-0.025492040440440178,
-0.024145886301994324,
0.025637570768594742,
0.009077446535229683,
0.006106204818934202,
-0.006803537253290415,
-0.024715879932045937,
-0.04183993488550186,
0.004193088971078396,
-0.011557524092495441,
-0.02949412167072296,
-0.006985449697822332,
-0.020289335399866104,
-0.005812112707644701,
0.004687285516411066,
-0.019682960584759712,
-0.021890169009566307,
0.010957211256027222,
0.002661990001797676,
0.018700631335377693,
0.003289588959887624,
-0.020519759505987167,
-0.049310483038425446,
-0.021162517368793488,
0.016990652307868004,
-0.02597714215517044,
-0.0008936463855206966,
0.012345812283456326,
-0.004287077113986015,
0.0028757373802363873,
-0.0007068068371154368,
0.007391721475869417,
-0.020495504140853882,
-0.01424983236938715,
-0.005454350728541613,
0.01444387249648571,
-0.0216476172208786,
-0.002802972448989749,
0.01726958341896534,
0.010654023848474026,
-0.01937977224588394,
-0.0009050159715116024,
-0.01099359430372715,
0.022351013496518135,
-0.01894318126142025,
0.0018403506837785244,
0.009932436048984528,
0.042543329298496246,
0.030246026813983917,
-0.07358977198600769,
-0.023418234661221504,
-0.02056826837360859,
-0.01243070513010025,
-0.02220548316836357,
0.0015348888700827956,
-0.030634108930826187,
0.0005286839441396296,
-0.016869375482201576,
-0.012806657701730728,
0.019816363230347633,
-0.0431254506111145,
0.009010745212435722,
-0.0016144757391884923,
-0.03866252303123474,
-0.006239607464522123,
-0.024206524714827538,
-0.04234929010272026,
0.003222887637093663,
0.029421355575323105,
0.003507884219288826,
0.021538469940423965,
-0.023163557052612305,
0.05287597328424454,
0.01606895960867405,
-0.008671174757182598,
-0.02361227571964264,
0.015086631290614605,
-0.0217325109988451,
0.025395020842552185,
0.021065497770905495,
0.013085590675473213,
-0.010805618017911911,
0.021708255633711815,
0.003165281843394041,
-0.039026349782943726,
0.014322597533464432,
-0.019234241917729378,
-0.01693001389503479,
0.022047825157642365,
-0.014492383226752281,
0.014540893025696278,
0.012649000622332096,
0.014480255544185638,
-0.012843040749430656,
-0.0029212157242000103,
-0.04421692714095116,
0.017863832414150238,
0.009653504006564617,
-0.038638267666101456,
0.03968123719096184,
-0.0329868458211422,
-0.025783101096749306,
0.003368417965248227,
-0.009380634874105453,
-0.014662167988717556,
0.013534309342503548,
-0.0019783012103289366,
0.015353436581790447,
0.010472111403942108,
-0.017427241429686546,
0.06548859179019928,
-0.00740384915843606,
-0.018397442996501923,
0.01680873893201351,
-0.015935556963086128,
-0.05437978729605675,
0.04945601522922516,
-0.04436245560646057,
0.0027756853960454464,
-0.02332121506333351,
-0.016432786360383034,
-0.04259184002876282,
0.0026119640097022057,
0.018664248287677765,
0.0011475662468001246,
-0.015268543735146523,
0.009611057117581367,
0.017766812816262245,
0.008064799010753632,
-0.024958429858088493,
-0.02648649737238884,
-0.028402645140886307,
-0.0036109681241214275,
-0.024182269349694252,
-0.021368684247136116,
0.0016675336519256234,
0.013898134231567383,
0.030658362433314323,
-0.008089053444564342,
-0.021114006638526917,
0.006151683162897825,
-0.004323459696024656,
-0.01067221537232399,
-0.0078222481533885,
-0.0006059968727640808,
-0.016723845154047012,
-0.0245218388736248,
-0.023430362343788147,
-0.039584215730428696,
0.038347210735082626,
-0.0372072234749794,
0.01249134261161089,
-0.005327011924237013,
-0.02396397292613983,
-0.023806316778063774,
0.042106740176677704,
-0.004820688161998987,
-0.007731291931122541,
-0.04276162385940552,
0.027529463171958923,
-0.017548516392707825,
0.026632027700543404,
0.020459121093153954,
-0.015644496306777,
0.018118510022759438,
0.04375608265399933,
-0.025516295805573463,
0.040651436895132065,
0.005760570522397757,
0.03698892518877983,
0.0187733955681324,
-0.010453919880092144,
-0.022945262491703033,
0.016444914042949677,
0.0193676445633173,
0.026729047298431396,
0.0014484802959486842,
-0.0004570558085106313,
0.024655241519212723,
0.002621059538796544,
0.012442832812666893,
-0.009514037519693375,
-0.009507973678410053,
-0.00048775356844998896,
0.035679154098033905,
0.0028226797003299,
0.018264040350914,
0.02648649737238884,
0.04504159837961197,
-0.0013681355630978942,
-0.018579356372356415,
-0.008889470249414444,
0.010599450208246708,
0.035727664828300476,
-0.02036210149526596,
-0.03570340946316719,
0.032720040529966354,
0.000863327644765377,
0.019961893558502197,
-0.0441441610455513,
0.040045060217380524,
0.025564806535840034,
0.06063758581876755,
0.0035867132246494293,
0.01577789895236492,
0.023648658767342567,
-0.03424810990691185,
-0.03320514038205147,
0.021065497770905495,
-0.022144846618175507,
0.05607764050364494,
-0.014565148390829563,
-0.03643106296658516,
0.003629159415140748,
-0.01562024187296629,
-0.01625087298452854,
-0.01731809414923191,
0.03029453754425049,
0.01615385338664055,
0.029591141268610954,
-0.04928622767329216,
0.052099812775850296,
-0.010617640800774097,
-0.03660084679722786,
-0.002702920464798808,
-0.004044526722282171,
-0.004490213003009558,
0.015838537365198135,
0.036625102162361145,
-0.03402981162071228,
0.0026877608615905046,
-0.0214778333902359,
0.026607772335410118,
0.017512135207653046,
-0.004529627505689859,
-0.010957211256027222,
-0.032210685312747955,
0.012612617574632168,
-0.014007282443344593,
-0.0015030541690066457,
-0.029591141268610954,
0.009993074461817741,
0.04438671097159386,
0.03347194567322731,
-0.04234929010272026,
-0.017111927270889282,
0.005433127749711275,
-0.03926889970898628,
-0.01684512197971344,
-0.012285174801945686,
0.048413049429655075,
0.06330563873052597,
0.0002647209621500224,
-0.02626820281147957,
0.02520097978413105,
0.015280671417713165,
-0.05297299474477768,
0.010526685044169426,
0.037789344787597656,
0.0162387453019619,
0.02498268522322178,
-0.040093570947647095,
0.04302842915058136,
0.01386175211519003,
-0.014334725216031075,
-0.004490213003009558,
-0.01075710728764534,
-0.026025651022791862,
-0.003374481573700905,
-0.03868677839636803,
-0.04106377437710762,
0.014067919924855232,
-0.009617120958864689,
0.015644496306777,
-0.01106029562652111,
0.031652819365262985,
0.01594768464565277,
-0.006269926205277443,
0.003301716409623623,
-0.01511088665574789,
0.02301802672445774,
0.015887048095464706,
-0.0020252952817827463,
-0.007137043867260218,
-0.009144147858023643,
0.003532139351591468,
-0.04664243012666702,
0.00048320574569515884,
0.005581689532846212,
0.07582123577594757,
0.01868850365281105,
-0.0056726462207734585,
-0.01787596009671688,
-0.02580735646188259,
0.02039848454296589,
0.04710327461361885,
-0.025395020842552185,
-0.002895444631576538,
-0.01770617440342903,
-0.0068763019517064095,
-0.00968382228165865,
0.021793147549033165,
0.03694041818380356,
0.057193368673324585,
-0.031822603195905685,
-0.010508493520319462,
0.006306308787316084,
0.03073112852871418,
-0.010381154716014862,
-0.016226617619395256,
0.015183650888502598,
0.0010475142626091838,
0.0019631418399512768,
0.004002080764621496,
-0.000023532593331765383,
0.0005836367490701377,
-0.014031536877155304,
0.005624135956168175,
0.024655241519212723,
0.010611576959490776,
0.008877342566847801,
0.00018759752856567502,
0.001605380093678832,
0.0007208292954601347,
-0.003419959917664528,
0.0032441108487546444,
0.011502949520945549,
-0.007100661285221577,
0.004617552272975445,
-0.014844080433249474,
0.014625785872340202,
-0.040045060217380524,
0.019343389198184013,
0.015401946380734444,
-0.0013249312760308385,
0.007658527232706547,
-0.019476791843771935,
0.010223496705293655,
-0.04062718152999878,
-0.037013180553913116,
0.016663208603858948,
-0.011963795870542526,
0.0033290034625679255,
-0.004851006902754307,
-0.009089574217796326,
0.00007068068225635216,
0.0071552349254488945,
0.016820866614580154,
0.0049268039874732494,
0.032259196043014526,
0.032380469143390656,
-0.012388258241117,
-0.02296951785683632,
0.008992553688585758,
-0.006554923020303249,
-0.006385137792676687,
-0.01980423554778099,
0.02995496802031994,
-0.016578316688537598,
-0.052051302045583725,
0.026777558028697968,
-0.015535349026322365,
-0.0191129669547081,
0.013328141532838345,
-0.004623615648597479,
-0.011139124631881714,
0.043222472071647644,
0.010350835509598255,
-0.012182090431451797,
-0.008234583772718906,
0.011903158389031887,
-0.00906531885266304,
-0.02298164553940296,
-0.03968123719096184,
0.036455314606428146,
0.012376131489872932,
0.010205305181443691,
-0.02344249002635479,
0.00033085382892750204,
0.008865214884281158,
-0.01343728881329298,
0.00003647729681688361,
-0.014492383226752281,
0.00609710905700922,
0.010144667699933052,
0.0018327709985896945,
0.025273745879530907,
0.001685724826529622,
-0.00992030929774046,
0.0017327190143987536,
0.0037837852723896503,
0.02503119595348835,
0.016735972836613655,
0.0439743772149086,
-0.009459462948143482,
0.0030470385681837797,
-0.03291407972574234,
0.003347194753587246,
-0.02176889218389988,
0.058357611298561096,
-0.024825027212500572,
-0.03356896713376045,
0.03672211989760399,
-0.010320517234504223,
-0.017342349514365196,
0.003259270219132304,
0.01992551051080227,
0.015632368624210358,
-0.0005294419243000448,
0.010065838694572449,
0.03820167854428291,
0.030488578602671623,
-0.03427236154675484,
0.008980426006019115,
0.011769755743443966,
-0.008143628016114235,
0.020713798701763153,
-0.006021312437951565,
0.018591484054923058,
0.019695088267326355,
-0.005102652590721846,
-0.020519759505987167,
-0.006282053887844086,
0.006906621158123016,
0.004362874198704958,
0.04225226864218712,
0.013813242316246033,
-0.017500007525086403,
0.028790725395083427,
0.015571732074022293,
-0.0016508582048118114,
-0.01069040596485138,
-0.018542973324656487,
-0.0005067028105258942,
-0.021247409284114838,
-0.0219871886074543,
-0.03519405424594879,
0.012115389108657837,
-0.015595986507833004,
-0.010217432864010334,
-0.012903678230941296,
0.008725748397409916,
0.026583516970276833,
-0.02301802672445774,
0.0003141784982290119,
-0.007519060745835304,
0.006803537253290415,
-0.012770275585353374,
0.016444914042949677,
-0.03871103376150131,
-0.019913382828235626,
0.00942914467304945,
0.008283094502985477,
0.00662162434309721,
0.015887048095464706,
0.014831953682005405,
-0.007385658100247383,
0.003359322203323245,
0.0036564464680850506,
-0.04475053772330284,
-0.0026650219224393368,
-0.060492053627967834,
0.002222367562353611,
-0.028135839849710464,
-0.01294006034731865,
0.0063002449460327625,
-0.0191129669547081,
-0.0436348058283329,
-0.006676197983324528,
0.03262301906943321,
0.01024168822914362,
-0.01360707450658083,
-0.009071382693946362,
-0.006457902956753969,
-0.002439146861433983,
0.013061336241662502,
0.0012195734307169914,
-0.0377165786921978,
0.016469167545437813,
0.0187733955681324,
0.02983369119465351,
0.015838537365198135,
0.017584899440407753,
-0.021999316290020943,
0.025395020842552185,
-0.010660087689757347,
0.024291416630148888,
-0.020932095125317574,
0.0011839488288387656,
-0.008562027476727962,
0.0006340417312458158,
0.058745693415403366,
0.0045478190295398235,
0.013643456622958183,
0.0033047483302652836,
-0.02626820281147957,
-0.019792107865214348,
0.019937638193368912,
0.010975402779877186,
0.030367301777005196,
-0.002956082345917821,
-0.04756412282586098,
-0.005860622506588697,
0.008258839137852192,
-0.0035503306426107883,
-0.04867985472083092,
-0.025783101096749306,
0.014298342168331146,
0.017851704731583595,
-0.007124916184693575,
0.0003842907026410103,
-0.010702533647418022,
0.006288117729127407,
0.01463791262358427,
-0.013328141532838345,
-0.008798513561487198,
-0.03487873822450638,
-0.0011339228367432952,
0.008301285095512867,
-0.00857415422797203,
0.019209986552596092,
0.026292456313967705,
0.010726789012551308,
0.020544013008475304,
-0.044726282358169556,
0.025298001244664192,
0.02503119595348835,
0.010702533647418022,
0.006997577380388975,
-0.03218642994761467,
0.004732763394713402,
-0.009896053932607174,
-0.01304920855909586,
0.023212067782878876,
0.00812543649226427,
-0.0014583339216187596,
-0.024073122069239616,
0.04084547609090805,
0.02515247091650963,
-0.02083507366478443,
-0.0030910009518265724,
0.007325020153075457,
-0.0008762131328694522,
0.000020026984202559106,
0.018106382340192795,
-0.007610016968101263,
-0.034054066985845566,
-0.0159840676933527,
0.010708597488701344,
-0.00659130560234189,
-0.007573634386062622,
-0.006961194798350334,
-0.04336800053715706,
0.015086631290614605,
0.02091996744275093,
-0.025055449455976486,
-0.049722820520401,
0.005157226696610451,
0.01611747033894062,
-0.04002080485224724,
-0.005763602443039417,
-0.02469162456691265,
0.012782403267920017,
0.02425503358244896,
-0.010205305181443691,
0.015401946380734444,
0.03453916683793068,
0.019695088267326355,
0.010611576959490776,
0.015038121491670609,
0.012327620759606361,
0.020471248775720596,
-0.022351013496518135,
-0.01386175211519003,
-0.022144846618175507,
-0.01424983236938715,
0.05345809459686279,
-0.011139124631881714,
0.03395704925060272,
0.025273745879530907,
-0.011224017478525639,
0.015486839227378368,
-0.0017418146599084139,
-0.018336806446313858,
0.024655241519212723,
-0.003986921161413193,
-0.003009140258654952,
-0.023636531084775925,
0.0008110277121886611,
-0.014043664559721947,
0.012200281955301762,
0.021914422512054443,
-0.017548516392707825,
0.003383577335625887,
0.022266121581196785,
0.033277906477451324,
-0.0019494983134791255,
-0.009598929435014725,
0.018118510022759438,
0.03536383807659149,
0.015547476708889008,
-0.021320175379514694,
0.014722805470228195,
-0.013206865638494492,
-0.03308386728167534,
0.007197681348770857,
0.011963795870542526,
-0.017669793218374252,
-0.0014492382761090994,
-0.003332035383209586,
0.005369458347558975,
-0.015268543735146523,
0.030634108930826187,
-0.01667533628642559,
0.015389818698167801,
-0.013655584305524826,
0.0030349111184477806,
-0.012527724727988243,
0.010744980536401272,
0.00639726547524333,
-0.0030985805206000805,
-0.018276168033480644,
0.01594768464565277,
-0.003468469949439168,
0.024776516482234,
-0.004872229881584644,
-0.0018312550382688642,
0.0008784870151430368,
-0.026947343721985817,
-0.022023571655154228,
-0.014844080433249474,
-0.010278070345520973,
0.024449074640870094,
0.00606375839561224,
-0.02232675813138485,
-0.038808055222034454,
-0.0015644497470930219,
-0.006930876057595015,
0.007537251804023981,
-0.006027375813573599,
-0.0011142155854031444,
-0.010793490335345268,
-0.022278249263763428,
0.02893625572323799,
0.043052684515714645,
-0.0014249832602217793,
-0.007943524047732353,
-0.0324774906039238,
0.002472497522830963,
-0.014710677787661552,
0.0248614102602005,
-0.010320517234504223,
-0.013328141532838345,
-0.004872229881584644,
-0.00740384915843606,
-0.016408530995249748,
-0.01680873893201351,
-0.027408188208937645,
-0.02065316215157509,
-0.013788986951112747,
0.019040200859308243,
0.011472631245851517,
-0.00008820874063530937,
-0.014407490380108356,
0.011842519976198673,
-0.01735447719693184,
-0.016687463968992233,
0.01709979958832264,
0.03136175870895386,
0.0034260235261172056,
0.04421692714095116,
-0.012636872939765453,
0.012600489892065525,
-0.0061941291205585,
0.03320514038205147,
-0.03381151705980301,
-0.014783442951738834,
0.03325365111231804,
-0.01654193364083767,
-0.023175684735178947,
0.04409565031528473,
0.017560644075274467,
-0.02472800761461258,
0.008289158344268799,
-0.006979385856539011,
0.0015599018661305308,
0.03708594664931297,
-0.026243947446346283,
0.02653500810265541,
-0.01200017798691988,
0.015923429280519485,
0.004941963125020266,
0.02866945043206215,
-0.038808055222034454,
0.03810465708374977,
-0.009956691414117813,
-0.016772355884313583,
-0.002866641851142049,
0.0027635579463094473,
-0.020252954214811325,
0.01642065867781639,
-0.002771137747913599,
0.019149350002408028,
0.021878041326999664,
-0.00021867429313715547,
-0.011448375880718231,
0.00793139636516571,
-0.03691616281867027,
-0.014577275142073631,
0.009507973678410053,
-0.004972281865775585,
0.00048206880455836654,
0.008992553688585758,
0.023030154407024384,
-0.008883406408131123,
0.03022177331149578,
0.006882365792989731,
-0.01603257842361927,
0.00854989979416132,
-0.026340967044234276,
0.006366946268826723,
-0.04829177260398865,
-0.019355516880750656,
0.09983371943235397,
0.005454350728541613,
-0.008598409593105316,
0.02061677910387516,
0.0020783531945198774,
-0.006900557316839695,
-0.008367986418306828,
-0.014225577935576439,
0.013570691458880901,
-0.03242897987365723,
-0.001838834723457694,
0.02558906190097332,
0.03977825492620468,
0.020071040838956833,
0.027117127552628517,
-0.01924636960029602,
0.009307869710028172,
0.02983369119465351,
-0.013218993321061134,
0.007367466576397419,
0.00029901909874752164,
0.011272527277469635,
-0.015353436581790447,
0.018142765387892723,
-0.0025664858985692263,
-0.016347892582416534,
-0.007961714640259743,
0.005302757024765015,
-0.007791929878294468,
-0.008434687741100788,
0.026413731276988983,
0.014395362697541714,
0.017512135207653046,
0.00009228282578988001,
-0.019137222319841385,
-0.007252254988998175,
-0.036115746945142746,
-0.0010982982348650694,
0.022314630448818207,
0.01735447719693184,
0.009914245456457138,
-0.0038050084840506315,
-0.014067919924855232,
0.02044699341058731,
0.00459632882848382,
-0.013413033448159695,
-0.030246026813983917,
-0.008695430122315884,
0.022278249263763428,
0.0041870251297950745,
0.0072280000895261765,
0.020507631823420525,
0.013873879797756672,
-0.006121364422142506,
-0.03361747786402702,
-0.013776859268546104,
0.03793487325310707,
-0.005763602443039417,
-0.002786297118291259,
-0.028912000358104706,
0.002460370073094964,
0.01230336632579565,
0.016008323058485985,
0.0042688860557973385,
0.026389477774500847
] | 2025-01-08 | 76 | 39767716 | [
"patients",
"CAR T-cells",
"CD19-targeting CAR T-cells",
"cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome",
"large B-cell lymphoma",
"lisocabtagene maraleucel",
"LBCL",
"R/R disease",
"Three CAR T-cells",
"R/R LBCL",
"BsAb",
"second-line treatments",
"terms",
"bispecific antibodies",
"CD19-targeting chimeric antigen receptor (CAR) T-cells",
"the three CAR T-cells",
"these three CAR T-cells",
"an additional treatment modality",
"first",
"tisagenlecleucel",
"Potential long-term toxicities",
"the treatment paradigm",
"the treatment arsenal",
"second",
"FDA",
"third",
"The safety profile",
"their safety profile",
"relapsed and/or refractory (R/R) LBCL",
"first-line chemo-immunotherapy"
] | [
"CD19-targeting CAR T-cells",
"axicabtagene ciloleucel",
"large B-cell lymphoma",
"lisocabtagene maraleucel",
"tisagenlecleucel"
] | 0 | 10.3390/biomedicines12122810
10.1056/NEJMoa011795
10.1182/blood-2010-03-276246
10.1016/S0140-6736(11)61040-4
10.3322/caac.21763
10.1016/S1470-2045(17)30444-8
10.3390/jpm14070666
10.1056/NEJMoa1707447
10.1056/NEJMoa1804980
10.1016/S0140-6736(20)31366-0
10.1056/NEJMoa2116133
10.1016/S0140-6736(22)00662-6
10.1200/JCO.22.01725
10.1056/NEJMoa2206913
10.1158/1535-7163.MCT-17-1097
10.1016/j.coi.2015.01.002
10.1056/NEJMoa1103849
10.1182/blood-2013-10-535245
10.1186/s40364-017-0102-y
10.1038/nbt0102-70
10.1158/0008-5472.CAN-10-0735
10.3389/fimmu.2013.00371
10.1158/1078-0432.CCR-18-0426
10.1182/bloodadvances.2017014845
10.1007/s00262-019-02354-4
10.1158/2326-6066.CIR-18-0466
10.1371/journal.pbio.0020234
10.3390/ijms20061283
10.3390/genes12060864
10.1038/nri.2016.153
10.1182/blood.2022018893
10.1200/JCO.19.02103
10.1200/JCO.19.02104
10.1056/NEJMoa2301665
10.1182/blood-2023-173873
10.1182/blood-2023-180241
10.1038/s41591-023-02572-5
10.1182/blood-2023-174510
10.1200/JCO.2024.42.16_suppl.2006
10.1182/blood-2022-158822
10.1056/NEJMoa2116596
10.1002/hon.3153
10.1182/blood-2023-184862
10.1182/blood.2022018730
10.1182/blood-2023-180952
10.1016/S1470-2045(21)00375-2
10.1182/blood.2023020854
10.1182/blood-2023-172978
10.1186/s13045-021-01144-9
10.1080/10428194.2022.2113526
10.1182/blood-2022-160216
10.1038/s41591-022-01969-y
10.1016/j.jtct.2024.01.074
10.3324/haematol.2022.280805
10.1038/s41571-024-00903-0
10.1182/blood-2014-05-552729
10.1056/NEJMoa1709866
10.1056/NEJMoa1709919
10.1016/j.bbmt.2018.12.758
10.1200/JCO.20.01616
10.1056/NEJMoa1914347
10.1182/blood.2020008865
10.1200/JCO.21.01992
10.1016/j.jcrc.2020.04.008
10.1038/s41591-023-02404-6
10.1186/s13054-024-04851-0
10.1016/j.bbmt.2019.08.003
10.1182/bloodadvances.2023010624
10.1038/s41591-024-03084-6
10.1182/blood.2024024166
10.1056/NEJMp2400209
10.1056/NEJMoa2401361
10.1038/s41591-024-02826-w
10.1182/blood.2019001641
10.1182/bloodadvances.2020003001
10.3389/fimmu.2019.01719
10.1172/JCI80445
10.1158/0008-5472.CAN-11-1620
10.1038/s41573-023-00807-1
10.1182/blood.2024025130
10.1182/blood.2024024526
10.1182/blood.2023022682
10.1182/blood.2023023419
10.1182/blood-2023-178786
10.1200/JCO.2023.41.16_suppl.7519
10.1200/JCO.2023.41.16_suppl.TPS7592
10.1182/blood-2023-174081 | [
"Saleh",
"Khalife",
"Arbab",
"Khoury",
"Chahine",
"Ibrahim",
"Tikriti",
"Masri",
"Hachem",
"Le Cesne"
] | [
"International Department, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"Department of Head and Neck, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"Department of Biopathology, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"International Department, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"International Department, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"International Department, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"International Department, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"International Department, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"International Department, Gustave Roussy Cancer Campus, 94800 Villejuif, France.",
"International Department, Gustave Roussy Cancer Campus, 94800 Villejuif, France."
] | [
"39767716",
"11807147",
"20548096",
"22118442",
"36633525",
"28668386",
"39063920",
"29226797",
"30501490",
"32888407",
"34891224",
"35717989",
"36548927",
"36507690",
"30181329",
"25621840",
"21830940",
"24986688",
"28652918",
"11753365",
"20647327",
"24273543",
"30097433",
"29986852",
"31177329",
"30890531",
"15314653",
"30875739",
"34198757",
"28163302",
"36821768",
"32667831",
"32401634",
"37272527",
"0",
"37710005",
"34904798",
"37294963",
"0",
"36542826",
"34516954",
"37890149",
"34493319",
"36048026",
"36138152",
"38281590",
"35770532",
"38769449",
"24876563",
"29385370",
"29385376",
"30592986",
"33434058",
"32242358",
"33534891",
"34724386",
"32361219",
"37400640",
"38444031",
"31419568",
"37672383",
"38977912",
"38483155",
"38265704",
"38865660",
"38266761",
"31650176",
"33180899",
"31379886",
"25866972",
"22186141",
"37907724",
"39115828",
"38657242",
"38805637",
"38696731"
] | [] | 6.096278 | 5.216356 |
39766419 | 66 | CAR-T Cells for the Treatment of Central Nervous System Tumours: Known and Emerging Neurotoxicities. | The advent of chimeric antigen receptor (CAR)-T cells has recently changed the prognosis of relapsing/refractory diffuse large B-cell lymphomas, showing response rates as high as 60 to 80%. Common toxicities reported in the pivotal clinical trials include the cytokine release syndrome (CRS) and the Immune effector Cell-Associated Neurotoxicity Syndrome (ICANS), a stereotyped encephalopathy related to myeloid cell activation and blood-brain barrier dysfunction, presenting with a distinctive cascade of dysgraphia, aphasia, disorientation, attention deficits, vigilance impairment, motor symptoms, seizures, and diffuse brain oedema. The tremendous oncological efficacy of CAR-T cells observed in systemic B-cell malignancies is leading to their growing use in patients with primary or secondary central nervous system (CNS) lymphomas and in patients with solid tumours, including several CNS cancers. Early studies conducted in adult and paediatric patients with solid CNS tumours reported a distinct profile of neurotoxicity referred to as Tumour inflammation-associated neurotoxicity (TIAN), corresponding to local inflammation at the tumour site manifesting with focal neurological deficits or mechanical complications (e.g., obstructive hydrocephalus). The present review summarises available data on the efficacy and safety of CAR-T cells for solid and haematological CNS malignancies, emphasising known and emerging phenotypes, ongoing challenges, and future perspectives. | [
0.015434326604008675,
0.043981000781059265,
0.05094693601131439,
0.03724271059036255,
-0.03976957127451897,
-0.02661169320344925,
0.027385685592889786,
0.012281443923711777,
-0.019714051857590675,
-0.010369226336479187,
-0.015866851434111595,
-0.00896351970732212,
-0.07161709666252136,
0.012679822742938995,
0.00682365708053112,
-0.04104438051581383,
0.013761136680841446,
0.0047179413959383965,
0.026748279109597206,
0.024426301941275597,
0.020385604351758957,
0.06465116143226624,
-0.0011908675078302622,
0.011928594671189785,
-0.008457009680569172,
-0.016435964033007622,
0.02192220650613308,
0.006243162322789431,
-0.0000540656728844624,
-0.005773644428700209,
0.01636767014861107,
-0.01340828649699688,
-0.020340075716376305,
-0.011012324132025242,
-0.0010891386773437262,
0.0361500158905983,
0.030208483338356018,
0.00005424351911642589,
-0.024631181731820107,
-0.03068653680384159,
0.006482189521193504,
0.053132329136133194,
0.010431828908622265,
0.10417032241821289,
-0.06993252038955688,
-0.02086365781724453,
-0.010568415746092796,
-0.04088503122329712,
-0.003437438514083624,
0.04885260388255119,
-0.030754830688238144,
0.038654111325740814,
-0.009544013999402523,
0.03574025630950928,
-0.05727546662092209,
0.03979233279824257,
-0.01204241719096899,
0.04236472398042679,
0.011638347059488297,
-0.018450621515512466,
0.008565140888094902,
-0.01193997636437416,
0.002524013165384531,
-0.012497707270085812,
-0.055499833077192307,
-0.019554700702428818,
-0.04029315337538719,
-0.019338436424732208,
0.02406206913292408,
0.01213347539305687,
0.008974901400506496,
-0.01417089719325304,
0.014910743571817875,
-0.003437438514083624,
0.022229528054594994,
0.017551423981785774,
-0.007000081706792116,
-0.010215566493570805,
0.0223774965852499,
-0.0181433018296957,
0.018063625320792198,
-0.0202262531965971,
-0.01332861091941595,
-0.0553632490336895,
-0.016538403928279877,
0.00032190416823141277,
-0.005856166128069162,
-0.03571749106049538,
-0.02068154141306877,
0.020396986976265907,
-0.022070176899433136,
0.018166065216064453,
-0.05818604677915573,
0.02574664168059826,
-0.02959384210407734,
0.020590484142303467,
0.022058794274926186,
-0.021592121571302414,
0.032257288694381714,
0.04555175080895424,
0.04386717826128006,
-0.00015588341921102256,
-0.038449227809906006,
0.002457142574712634,
0.06975040584802628,
0.05896003916859627,
-0.03747035562992096,
-0.02638404816389084,
0.03797117620706558,
0.0031187355052679777,
0.062101539224386215,
0.010340770706534386,
-0.027340156957507133,
0.04024762287735939,
-0.019896166399121284,
-0.0639226958155632,
-0.020488044247031212,
-0.00980580598115921,
0.014819685369729996,
0.03284916281700134,
-0.017323778942227364,
0.03025401197373867,
0.034624792635440826,
-0.0022593759931623936,
-0.00697731738910079,
-0.03662807121872902,
0.06647232174873352,
-0.03428332880139351,
-0.01077329646795988,
-0.06706419587135315,
0.01872379519045353,
-0.020283164456486702,
0.02916131541132927,
-0.019270144402980804,
-0.07644316554069519,
-0.00388703728094697,
-0.024653946980834007,
-0.02829626575112343,
-0.03895004838705063,
-0.044436290860176086,
0.030367834493517876,
0.0016490030102431774,
0.024608416482806206,
-0.004145983140915632,
-0.021603504195809364,
-0.027112511917948723,
0.0030760520603507757,
0.010505814105272293,
-0.019907549023628235,
0.03706059604883194,
-0.02447183057665825,
0.10080117732286453,
0.041203733533620834,
0.0016091651050373912,
0.023584015667438507,
-0.05855027586221695,
0.008565140888094902,
0.06692761182785034,
-0.0319385826587677,
-0.05732099339365959,
-0.0007974686450324953,
-0.025427939370274544,
-0.021136831492185593,
-0.021614886820316315,
0.03555813804268837,
0.006328529212623835,
0.00322117586620152,
0.019930314272642136,
-0.03851752355694771,
-0.00273885321803391,
-0.03002636693418026,
-0.00979442335665226,
-0.0766708105802536,
-0.015491237863898277,
-0.03553537279367447,
-0.004917130805552006,
0.013977399095892906,
0.0106537826359272,
0.0049854242242872715,
-0.015479855239391327,
-0.005913077387958765,
0.03234834596514702,
0.02979872189462185,
-0.006613085512071848,
-0.05709334835410118,
0.01522944588214159,
-0.01934981904923916,
0.03662807121872902,
-0.020590484142303467,
0.0065049538388848305,
0.01724410429596901,
-0.027749916538596153,
0.04489158093929291,
0.007626105099916458,
0.020579101517796516,
-0.0202603992074728,
0.014330248348414898,
0.03303128108382225,
-0.05595512315630913,
-0.04721355810761452,
0.046302977949380875,
-0.020112430676817894,
-0.02963937073945999,
-0.005981370806694031,
-0.01791565679013729,
0.01574164628982544,
-0.002619339618831873,
0.02793203294277191,
-0.020146576687693596,
0.002265067072585225,
0.04156796634197235,
0.006863494869321585,
-0.007540738210082054,
0.03646871820092201,
-0.03938257321715355,
-0.0170733705163002,
-0.017801834270358086,
0.04650786146521568,
0.008269201964139938,
-0.021774237975478172,
0.016970930621027946,
-0.0017870126757770777,
-0.001308958395384252,
0.028637733310461044,
-0.0361727811396122,
0.03901834040880203,
-0.0021498219575732946,
-0.001277657225728035,
0.023151488974690437,
-0.044003766030073166,
0.011165983974933624,
0.007956190034747124,
0.032871928066015244,
-0.03649148344993591,
-0.062101539224386215,
-0.013305846601724625,
0.05627382919192314,
0.027317391708493233,
0.051447756588459015,
-0.023060431703925133,
0.040133800357580185,
0.013886340893805027,
-0.01554814912378788,
-0.010522887110710144,
-0.017585571855306625,
-0.000019529890778358094,
-0.0039809406735002995,
-0.029548311606049538,
0.04721355810761452,
-0.019031116738915443,
-0.01791565679013729,
0.02112545073032379,
0.033759742975234985,
-0.006499262992292643,
-0.0009596656891517341,
-0.03214346617460251,
0.037606943398714066,
-0.05736652389168739,
-0.019657140597701073,
-0.013920487836003304,
0.04008827358484268,
-0.02406206913292408,
-0.00980580598115921,
-0.061873894184827805,
-0.07134392112493515,
-0.015115623362362385,
-0.010608254000544548,
0.014375777915120125,
0.01700507663190365,
-0.00772854546085,
0.028888141736388206,
0.014831067062914371,
0.013385522179305553,
-0.030572714284062386,
-0.043730590492486954,
0.02510923705995083,
-0.0057394979521632195,
0.020761217921972275,
-0.03362315520644188,
0.03316786512732506,
-0.0013886340893805027,
0.017813216894865036,
-0.0057935635559260845,
-0.048260726034641266,
-0.024198656901717186,
-0.03255322575569153,
-0.005099246744066477,
-0.02702145278453827,
-0.014500982128083706,
-0.042091548442840576,
0.006863494869321585,
-0.008496847003698349,
-0.045893218368291855,
-0.005062254145741463,
-0.003998014144599438,
-0.012816409580409527,
0.016561169177293777,
0.010380608960986137,
-0.03298575058579445,
-0.01247494202107191,
-0.029047492891550064,
0.004905748181045055,
-0.020499426871538162,
-0.051629871129989624,
0.013749754056334496,
0.04020209610462189,
0.013305846601724625,
0.007933425717055798,
0.0531778559088707,
0.032462168484926224,
0.01446683518588543,
-0.010369226336479187,
0.04345741868019104,
0.011609891429543495,
-0.002031730953603983,
0.006891950499266386,
0.06369505077600479,
-0.03599066287279129,
0.04577939584851265,
-0.030936947092413902,
-0.035922370851039886,
0.010380608960986137,
-0.03790288046002388,
0.0005047314916737378,
0.00012520470772869885,
-0.035876840353012085,
0.011700949631631374,
0.03965574875473976,
0.04309318587183952,
-0.014865214005112648,
0.031028004363179207,
-0.004843146074563265,
0.06342187523841858,
0.009982230141758919,
0.02129618264734745,
-0.015411562286317348,
-0.017733540385961533,
-0.05795840173959732,
0.010574107058346272,
-0.011700949631631374,
-0.005890312604606152,
0.04147690534591675,
-0.03303128108382225,
0.06533409655094147,
-0.015183917246758938,
0.02360677905380726,
-0.007796838879585266,
0.0023575478699058294,
0.023902717977762222,
0.007802530191838741,
-0.03721994534134865,
0.00895213708281517,
0.01086435467004776,
0.0032780871260911226,
-0.018484769389033318,
0.02383442409336567,
-0.05905109643936157,
0.0017372154397889972,
0.003867118386551738,
0.002930928487330675,
-0.0015650589484721422,
-0.023356370627880096,
-0.033349983394145966,
0.07494071125984192,
0.03473861515522003,
0.06724631041288376,
-0.046302977949380875,
0.07562364637851715,
-0.033122338354587555,
-0.04407205805182457,
-0.009304986335337162,
0.009122870862483978,
0.025678347796201706,
-0.026679987087845802,
-0.014614804647862911,
0.0638316422700882,
-0.013806665316224098,
-0.01074484083801508,
-0.0046866401098668575,
-0.0006765322759747505,
0.03851752355694771,
-0.006072428543120623,
-0.01479692105203867,
-0.014876596629619598,
-0.005136238876730204,
0.004732169210910797,
0.012554618529975414,
-0.022866934537887573,
-0.037993937730789185,
0.0159465279430151,
-0.0067610545083880424,
-0.02538241073489189,
-0.014068457297980785,
0.016470111906528473,
-0.021888060495257378,
0.08067736774682999,
-0.0101301996037364,
0.05709334835410118,
0.04989976808428764,
0.0007313093519769609,
0.054862428456544876,
0.0002180411684093997,
-0.01180338952690363,
-0.0533144436776638,
0.04086226597428322,
0.013579020276665688,
0.0341012105345726,
0.00010181775724049658,
-0.006339911371469498,
-0.05021847411990166,
0.012702587060630322,
-0.00354272429831326,
0.03432885557413101,
0.032257288694381714,
0.035034555941820145,
-0.04735014587640762,
-0.02813691459596157,
0.0553177185356617,
-0.031597115099430084,
0.07981231063604355,
0.041180968284606934,
-0.01703922264277935,
-0.023902717977762222,
-0.01096110325306654,
-0.012008270248770714,
0.00852530263364315,
0.010135890915989876,
-0.013909105211496353,
0.02897920086979866,
-0.013715607114136219,
-0.0015693273162469268,
0.08199770748615265,
-0.018860382959246635,
0.00947572011500597,
0.013078201562166214,
0.02535964548587799,
-0.009834261611104012,
0.04022486135363579,
-0.028660496696829796,
0.018905911594629288,
-0.01287332084029913,
0.011359482072293758,
0.0006587475072592497,
-0.02067016065120697,
0.033736977726221085,
-0.0255872905254364,
-0.015195298939943314,
0.023128725588321686,
-0.015889616683125496,
-0.035671960562467575,
-0.01075622346252203,
0.01576441153883934,
-0.004649647977203131,
-0.0170733705163002,
-0.06050802394747734,
-0.006430969573557377,
0.01894005760550499,
-0.05149328336119652,
-0.003986631985753775,
0.00442200293764472,
0.016356289386749268,
-0.026475105434656143,
0.0020303083583712578,
-0.011860300786793232,
-0.004695176612585783,
0.006527718622237444,
0.04152243584394455,
0.014045692048966885,
0.013544873334467411,
-0.027317391708493233,
-0.0054833972826600075,
0.0034402841702103615,
-0.025883229449391365,
0.02597428672015667,
0.01234973780810833,
0.03250769525766373,
0.019110791385173798,
0.019475024193525314,
0.04202325642108917,
0.020522190257906914,
-0.006840730085968971,
0.004902902990579605,
-0.021842531859874725,
-0.01788150891661644,
0.07125286757946014,
0.056091710925102234,
-0.016674991697072983,
-0.015092859044671059,
-0.041818372905254364,
0.07298296689987183,
-0.03860858082771301,
0.004541516304016113,
0.0309141818434,
-0.009157017804682255,
-0.010386300273239613,
-0.02724909782409668,
-0.02260514162480831,
-0.016527021303772926,
0.00011613448441494256,
-0.01011881697922945,
0.00224087992683053,
0.03237111121416092,
-0.00913994386792183,
0.020806746557354927,
0.01532050408422947,
0.04518751800060272,
0.010670856572687626,
0.07753586769104004,
0.0025510459672659636,
0.015081476420164108,
-0.016731902956962585,
-0.03155158832669258,
0.04220537096261978,
-0.002800032729282975,
-0.03895004838705063,
-0.021034391596913338,
-0.047577790915966034,
-0.03938257321715355,
-0.0029366195667535067,
-0.0029764575883746147,
0.02110268548130989,
-0.007563502993434668,
-0.014045692048966885,
-0.0027018608525395393,
0.030390597879886627,
-0.025450702756643295,
0.0011325335362926126,
-0.02175147272646427,
-0.013897723518311977,
-0.04539240151643753,
0.028455616906285286,
-0.017744923010468483,
0.013294463977217674,
0.013818047940731049,
-0.030777595937252045,
0.00927653070539236,
-0.04008827358484268,
0.003576871007680893,
-0.02428971417248249,
-0.0037106124218553305,
0.013692842796444893,
-0.009037503972649574,
0.008656198158860207,
0.002478484297171235,
0.0007145917043089867,
0.0069431704469025135,
0.004863064736127853,
-0.02938896045088768,
0.011928594671189785,
-0.01043752022087574,
0.010460284538567066,
-0.037197183817625046,
0.017301015555858612,
0.013169259764254093,
0.027749916538596153,
-0.017710775136947632,
-0.026566164568066597,
-0.040361445397138596,
-0.004911439493298531,
-0.028501145541667938,
-0.016925400123000145,
-0.009458647109568119,
-0.004868756048381329,
-0.035239435732364655,
-0.025223059579730034,
0.016936782747507095,
0.00554030854254961,
0.009105796925723553,
-0.016663609072566032,
0.017084753140807152,
-0.024358008056879044,
-0.005918768234550953,
0.004137446638196707,
0.005520389880985022,
0.031050769612193108,
-0.00927653070539236,
-0.014626187272369862,
0.017175810411572456,
0.010454593226313591,
0.02340189926326275,
-0.006726908031851053,
-0.044413525611162186,
0.007227726746350527,
0.0404297411441803,
-0.02642957679927349,
0.03307680785655975,
-0.049307893961668015,
-0.0029480019584298134,
-0.013157877139747143,
-0.018860382959246635,
0.01596929132938385,
0.009629380889236927,
0.02836455963551998,
0.025245822966098785,
-0.05126563832163811,
0.015218064188957214,
0.0340329185128212,
-0.028023092076182365,
-0.03605895861983299,
0.051675401628017426,
-0.010261095128953457,
-0.01830265298485756,
-0.009896863251924515,
-0.029958073049783707,
-0.015161152929067612,
0.03583131358027458,
-0.00925945769995451,
-0.009862716309726238,
0.01620831899344921,
0.022889697924256325,
0.030595479533076286,
0.039109401404857635,
-0.009982230141758919,
0.007091139908879995,
0.024562887847423553,
0.029980838298797607,
-0.0234474278986454,
0.013601784594357014,
0.027522273361682892,
-0.003682156791910529,
-0.029525548219680786,
0.014250572770833969,
-0.01981649175286293,
0.0031386546324938536,
0.006522027309983969,
-0.018598591908812523,
-0.0033805272541940212,
0.0007284638122655451,
0.0039382572285830975,
-0.01311234850436449,
-0.016766048967838287,
-0.023948246613144875,
0.0170506052672863,
0.017084753140807152,
-0.01319202408194542,
-0.002864057896658778,
0.007102522067725658,
-0.01395463477820158,
-0.008161070756614208,
-0.0028540983330458403,
-0.030117424204945564,
0.006869185715913773,
-0.0054833972826600075,
-0.028660496696829796,
0.0138635765761137,
-0.025177529081702232,
-0.026702750474214554,
-0.011382246389985085,
0.014660334214568138,
-0.003169955685734749,
0.00809846818447113,
-0.006391131319105625,
0.028865378350019455,
-0.009128562174737453,
-0.013476580381393433,
-0.050400588661432266,
-0.010403373278677464,
-0.004535825457423925,
0.03904110565781593,
0.07079757750034332,
-0.02852391079068184,
-0.005412258207798004,
-0.005608601961284876,
-0.0010379186132922769,
0.006806583609431982,
0.008434244431555271,
0.01287332084029913,
-0.00989117193967104,
0.02617916651070118,
0.009834261611104012,
0.06451457738876343,
0.05386079102754593,
0.015525384806096554,
0.007495209574699402,
0.0446867011487484,
0.01162696536630392,
0.012201768346130848,
-0.017813216894865036,
-0.015035947784781456,
0.013066818937659264,
-0.0063057648949325085,
0.022240910679101944,
-0.004114682320505381,
-0.0725732073187828,
0.02193358913064003,
0.027567801997065544,
0.025268588215112686,
0.006129339803010225,
0.02875155583024025,
0.004689485765993595,
-0.0052102236077189445,
-0.01193997636437416,
-0.030299540609121323,
0.019839255139231682,
0.00959523394703865,
-0.006533409468829632,
-0.01895144023001194,
0.003867118386551738,
-0.008491155691444874,
-0.011433467268943787,
0.015912380069494247,
0.024813298135995865,
0.03869963809847832,
-0.031369470059871674,
0.03448820859193802,
-0.012304208241403103,
0.014375777915120125,
-0.04350294545292854,
0.041886668652296066,
0.03935980796813965,
-0.022969374433159828,
0.0017044914420694113,
-0.005030952859669924,
-0.0027530810330063105,
-0.020909186452627182,
0.014227808453142643,
0.009157017804682255,
0.03514837846159935,
0.007876514457166195,
0.004891520366072655,
-0.018166065216064453,
0.03212070092558861,
-0.019008351489901543,
-0.008457009680569172,
0.03678742051124573,
0.028637733310461044,
-0.030549950897693634,
0.03708336129784584,
0.0005829844740219414,
-0.0009653568267822266,
-0.004293952602893114,
-0.01897420547902584,
-0.021034391596913338,
-0.013692842796444893,
-0.04297936335206032,
0.028797084465622902,
-0.018780706450343132,
-0.015832705423235893,
-0.028045855462551117,
-0.020727071911096573,
0.035034555941820145,
-0.013749754056334496,
-0.043798886239528656,
0.005765107925981283,
0.017938420176506042,
0.022832786664366722,
0.0298442505300045,
0.015855468809604645,
-0.01873517781496048,
-0.01681157760322094,
0.007830985821783543,
0.007324475795030594,
-0.01395463477820158,
0.016652226448059082,
-0.0033236159943044186,
-0.01615140773355961,
0.0013701379066333175,
-0.006778127979487181,
-0.016970930621027946,
-0.025837700814008713,
-0.016879871487617493,
-0.011262733489274979,
-0.03387356549501419,
-0.008087086491286755,
0.013704225420951843,
-0.03323616087436676,
0.01979372650384903,
0.03155158832669258,
-0.02214985154569149,
0.01098386850208044,
-0.015809940174221992,
-0.031232884153723717,
0.007683016359806061,
-0.021216508001089096,
0.00739276921376586,
0.008035866543650627,
-0.058003928512334824,
0.006465116050094366,
0.006328529212623835,
0.0001315183035330847,
-0.00884400587528944,
-0.01664084382355213,
-0.006470807362347841,
0.016026202589273453,
0.009441573172807693,
-0.022320585325360298,
-0.02918408066034317,
-0.0001938538916874677,
-0.008895225822925568,
-0.0036793111357837915,
-0.02110268548130989,
0.05791287124156952,
-0.007557811681181192,
-0.0014256264548748732,
-0.009014739654958248,
0.024608416482806206,
0.036741893738508224,
-0.06979593634605408,
-0.019645757973194122,
-0.009646453894674778,
-0.015593677759170532,
0.005176076665520668,
-0.011000941507518291,
-0.040179330855607986,
0.013510726392269135,
0.03571749106049538,
-0.012395266443490982,
0.019110791385173798,
-0.02494988404214382,
-0.02729462832212448,
0.028865378350019455,
-0.015127005986869335,
-0.008462700061500072,
-0.006328529212623835,
-0.039724040776491165,
0.013818047940731049,
0.04944447800517082,
-0.006920406129211187,
0.02447183057665825,
-0.016777431592345238,
0.07480412721633911,
0.01502456609159708,
0.022286439314484596,
-0.03325892612338066,
0.008246437646448612,
-0.031847525388002396,
0.0009433036902919412,
0.01576441153883934,
0.007079757284373045,
-0.02238887920975685,
0.02212708815932274,
0.019110791385173798,
-0.02535964548587799,
0.02065877802670002,
-0.01395463477820158,
-0.029684899374842644,
-0.011393629014492035,
0.010522887110710144,
0.0180977713316679,
0.0191335566341877,
-0.00011951359192607924,
0.0007697244291193783,
0.011359482072293758,
-0.035057321190834045,
0.014022927731275558,
0.029684899374842644,
-0.022718964144587517,
0.01574164628982544,
-0.026133637875318527,
-0.02982148714363575,
-0.005198840983211994,
-0.014193661510944366,
-0.003070360980927944,
0.011165983974933624,
0.01827988773584366,
0.01213347539305687,
0.02793203294277191,
-0.01827988773584366,
0.04712250083684921,
0.01849615015089512,
-0.0143871596083045,
0.0028512529097497463,
-0.004521597642451525,
-0.031642645597457886,
0.0036451644264161587,
-0.03348657116293907,
0.014990419149398804,
-0.00927084032446146,
0.004703713580965996,
-0.039063870906829834,
0.02977595664560795,
0.01724410429596901,
0.006089502014219761,
-0.006043972913175821,
-0.016105879098176956,
0.012588764540851116,
0.03068653680384159,
-0.003522805403918028,
-0.02320840023458004,
-0.022252291440963745,
0.024335242807865143,
-0.024767769500613213,
0.002330515068024397,
0.0008301926427520812,
0.028774319216609,
-0.00956677831709385,
-0.0045159063301980495,
-0.024016540497541428,
-0.009117179550230503,
0.003961022011935711,
0.01727825030684471,
-0.009663527831435204,
-0.022844169288873672,
-0.031597115099430084,
0.010306624695658684,
-0.01660669781267643,
-0.013704225420951843,
0.035694725811481476,
-0.04033868387341499,
0.0033378438092768192,
-0.006379749160259962,
0.010539960116147995,
-0.019053880125284195,
0.019918931648135185,
0.02194497175514698,
-0.015047330409288406,
-0.011792007833719254,
0.020522190257906914,
-0.03177923336625099,
0.03180199861526489,
-0.020374221727252007,
-0.015798557549715042,
-0.003978095017373562,
-0.001986202085390687,
-0.010465975850820541,
0.014626187272369862,
-0.0018837618408724666,
0.05927874147891998,
-0.00990255456417799,
-0.011331026442348957,
0.005662667565047741,
-0.0031500367913395166,
-0.002909586764872074,
-0.01747174933552742,
-0.002930928487330675,
-0.005224451422691345,
-0.003906956408172846,
0.00002736630085564684,
-0.017164427787065506,
-0.019531935453414917,
0.012395266443490982,
-0.014933507889509201,
0.04457287862896919,
0.02150106430053711,
0.01938396692276001,
0.006817965768277645,
0.028410088270902634,
-0.019213233143091202,
-0.003986631985753775,
-0.017175810411572456,
-0.020385604351758957,
0.0320068784058094,
-0.009600925259292126,
-0.040361445397138596,
0.013135112822055817,
0.03004913218319416,
-0.0014491023030132055,
-0.03724271059036255,
0.004336636047810316,
0.034397151321172714,
0.06242024153470993,
0.008781403303146362,
0.022001883015036583,
0.03512561321258545,
-0.02768162451684475,
-0.05003635585308075,
-0.011501760222017765,
-0.02961660549044609,
0.026475105434656143,
-0.023356370627880096,
0.0023319378960877657,
0.018609972670674324,
-0.03881346061825752,
-0.025905992835760117,
0.003286623628810048,
0.00655048293992877,
0.01637905277311802,
0.029297903180122375,
-0.04725908860564232,
0.026771044358611107,
0.009982230141758919,
-0.0028754400555044413,
0.013305846601724625,
0.01106923446059227,
-0.004271188285201788,
0.03243940323591232,
-0.002558159874752164,
-0.025723878294229507,
0.010887118987739086,
0.0006199767231009901,
0.012247297912836075,
0.024403536692261696,
-0.01937258429825306,
-0.023584015667438507,
-0.044003766030073166,
0.0005292744608595967,
-0.004225659184157848,
-0.04509646072983742,
-0.015889616683125496,
-0.003909801598638296,
0.06369505077600479,
0.027613330632448196,
-0.0404525063931942,
-0.0026278761215507984,
-0.000555951613932848,
-0.03726547583937645,
-0.045437928289175034,
-0.022696200758218765,
0.046758268028497696,
0.044436290860176086,
-0.03963298350572586,
-0.0006502108299173415,
0.04272895306348801,
0.017756305634975433,
-0.02300352044403553,
0.015274975448846817,
0.02387995272874832,
-0.0022949455305933952,
0.05481690168380737,
-0.03280363604426384,
0.03255322575569153,
0.007387077901512384,
0.019645757973194122,
0.023265311494469643,
0.0009653568267822266,
-0.04129479080438614,
-0.022047411650419235,
-0.050127413123846054,
-0.06729184091091156,
0.02449459582567215,
0.0031841835007071495,
-0.0007039208430796862,
0.012805027887225151,
0.03212070092558861,
0.031187355518341064,
-0.01086435467004776,
0.012918850407004356,
-0.0016817270079627633,
0.026088109239935875,
0.03961021825671196,
0.019714051857590675,
0.0022038875613361597,
-0.006988699547946453,
-0.02319701947271824,
-0.00580210005864501,
0.013465197756886482,
0.0212734192609787,
0.03494349867105484,
-0.020920569077134132,
-0.02045389823615551,
-0.027385685592889786,
-0.038449227809906006,
-0.006897641345858574,
0.005022416356950998,
-0.02490435540676117,
-0.015468473546206951,
-0.004305334761738777,
-0.029958073049783707,
0.00915132649242878,
0.043730590492486954,
0.005873239133507013,
0.02872879058122635,
-0.016447346657514572,
0.0065903207287192345,
0.023310841992497444,
0.026247460395097733,
0.006026899442076683,
-0.0035910988226532936,
0.03214346617460251,
-0.028819847851991653,
-0.0045045241713523865,
0.029912544414401054,
0.007324475795030594,
0.013897723518311977,
-0.025268588215112686,
-0.002297790953889489,
0.021421387791633606,
0.0031614189501851797,
0.0014426998095586896,
-0.019645757973194122,
-0.008235055953264236,
-0.018029479309916496,
-0.014193661510944366,
-0.011257042177021503,
0.0026890558656305075,
0.005605756305158138,
-0.011012324132025242,
-0.014535129070281982,
0.018222976475954056,
0.0028839767910540104,
-0.019634375348687172,
0.021159596741199493,
-0.009373280219733715,
-0.009777350351214409,
-0.03109629824757576,
-0.0015920917503535748,
-0.011666802689433098,
-0.06155519187450409,
0.012611529789865017,
-0.0024087680503726006,
-0.021785620599985123,
0.0034431295935064554,
-0.025723878294229507,
0.01766524650156498,
0.005790717899799347,
0.01725548692047596,
0.0015223755035549402,
0.002384580671787262,
0.020977480337023735,
-0.002521167742088437,
-0.012622911483049393,
-0.01726686768233776,
-0.014455453492701054,
-0.013840812258422375,
-0.06114542856812477,
0.005745188798755407,
-0.014398542232811451,
-0.019429495558142662,
0.0031728013418614864,
0.017733540385961533,
-0.018826236948370934,
0.016231084242463112,
0.030367834493517876,
0.0055687641724944115,
-0.002095756120979786,
0.023993775248527527,
0.024198656901717186,
-0.010875736363232136,
0.0024841753765940666,
0.010699312202632427,
-0.02765885926783085,
-0.013499344699084759,
-0.0017244103364646435,
0.0024002313148230314,
-0.0033662994392216206,
-0.02813691459596157,
-0.02045389823615551,
0.051675401628017426,
-0.008513920940458775,
-0.003781751496717334,
0.008280584588646889,
0.014751391485333443,
0.01599205657839775,
0.002736007561907172,
-0.008303348906338215,
0.004874447360634804,
-0.003989477641880512,
-0.003070360980927944,
0.011183056980371475,
0.032462168484926224,
0.01875794306397438,
0.03134670853614807,
-0.013442433439195156,
-0.008849697187542915,
-0.02834179438650608,
-0.014421306550502777,
-0.0024656790774315596,
0.043753355741500854,
-0.033782508224248886,
-0.0298442505300045,
0.03371421620249748,
0.019065262749791145,
-0.013260317035019398,
0.00884400587528944,
0.014216425828635693,
-0.009344824589788914,
0.002491289284080267,
-0.0009845643071457744,
0.03107353299856186,
0.0009532631374895573,
-0.03854028880596161,
0.005472015123814344,
0.04459564387798309,
-0.015445709228515625,
-0.02212708815932274,
0.0016774586401879787,
-0.006516336463391781,
0.014865214005112648,
0.007927734404802322,
-0.016720520332455635,
-0.022684818133711815,
0.017505895346403122,
0.026019815355539322,
0.03863134607672691,
0.0003243940300308168,
-0.006436660420149565,
0.023811660706996918,
-0.0071992711164057255,
-0.027613330632448196,
0.0002553891681600362,
-0.026702750474214554,
0.013522109016776085,
0.001459773164242506,
-0.03510284796357155,
-0.025928758084774017,
-0.014398542232811451,
-0.006038282066583633,
0.002795764245092869,
-0.022286439314484596,
-0.005161848850548267,
-0.01641320064663887,
-0.026975924149155617,
-0.012247297912836075,
-0.0016020511975511909,
0.012645675800740719,
-0.02447183057665825,
0.006522027309983969,
-0.021205125376582146,
-0.019668523222208023,
0.008041556924581528,
-0.026292989030480385,
0.006567556411027908,
-0.01394325215369463,
0.016140025109052658,
0.017301015555858612,
0.02428971417248249,
0.005699660163372755,
-0.027818210422992706,
0.008263510651886463,
-0.06032590568065643,
0.008451318368315697,
-0.02768162451684475,
0.004561435431241989,
0.01492212526500225,
-0.014307484030723572,
-0.030299540609121323,
-0.008758638985455036,
0.028273500502109528,
0.01726686768233776,
0.0031585735268890858,
-0.003929720725864172,
-0.006203324533998966,
0.0022707581520080566,
0.007074066437780857,
0.01979372650384903,
-0.02490435540676117,
0.04095332324504852,
-0.005161848850548267,
0.030413363128900528,
0.019543318077921867,
0.0014853831380605698,
-0.01011881697922945,
-0.004882983863353729,
-0.007859441451728344,
-0.001964860362932086,
-0.007421224843710661,
0.008593596518039703,
-0.011331026442348957,
-0.006607394199818373,
0.05172092840075493,
0.015195298939943314,
0.016504257917404175,
-0.012076564133167267,
0.006732598878443241,
-0.019770963117480278,
0.023310841992497444,
-0.020943334326148033,
0.024995414540171623,
0.017414838075637817,
-0.019122174009680748,
-0.011040779761970043,
-0.0007377118454314768,
-0.017357926815748215,
-0.012861939147114754,
0.00873587466776371,
0.002703283680602908,
0.040361445397138596,
-0.02365230955183506,
-0.01659531518816948,
-0.021899443119764328,
0.0015807094750925899,
0.02067016065120697,
-0.024380773305892944,
-0.009555395692586899,
-0.0191677026450634,
-0.029275137931108475,
-0.003147191135212779,
0.011894447728991508,
0.0010450325207784772,
0.004000859800726175,
0.013783900998532772,
0.03282640129327774,
-0.030094660818576813,
0.018632737919688225,
0.014432689175009727,
0.006869185715913773,
-0.0027687314432114363,
-0.00830904021859169,
0.019520552828907967,
-0.011541598476469517,
-0.021410005167126656,
0.04238748550415039,
0.016561169177293777,
0.002481329720467329,
-0.0024770614691078663,
0.020692924037575722,
0.010255403816699982,
-0.014648951590061188,
0.010784679092466831,
-0.012087945826351643,
-0.015195298939943314,
-0.01872379519045353,
-0.006345602683722973,
0.022684818133711815,
-0.02765885926783085,
0.004666720982640982,
-0.01310096587985754,
0.006368367001414299,
-0.0202376339584589,
0.008291966281831264,
0.01159850973635912,
0.026315754279494286,
-0.008246437646448612,
-0.0061521041207015514,
-0.05622829869389534,
0.005713887978345156,
-0.001315360888838768,
-0.04744120314717293,
-0.011097690090537071,
-0.004669566638767719,
0.00017820330685935915,
0.04309318587183952,
-0.024608416482806206,
0.006510645151138306,
0.03221175819635391,
0.03530772775411606,
-0.0023219783324748278,
0.009839951992034912,
0.01894005760550499,
0.030823124572634697,
-0.01418227981775999,
0.01426195539534092,
-0.02342466451227665,
0.002632144605740905,
0.010187110863626003,
-0.005779335740953684,
0.012713969685137272,
0.003522805403918028,
-0.0014049960300326347,
0.014296101406216621,
-0.0025510459672659636,
-0.002168318023905158,
0.02170594409108162,
0.005759416613727808,
0.0011133260559290648,
-0.02831902913749218,
-0.031187355518341064,
-0.02387995272874832,
0.017540041357278824,
-0.00884400587528944,
0.0013608898734673858,
-0.0041203731670975685,
0.0180977713316679,
0.038858991116285324,
-0.002707551931962371,
-0.019270144402980804,
0.015707500278949738,
0.04816966876387596,
0.005662667565047741,
-0.029115786775946617,
-0.014432689175009727,
0.003229712601751089,
-0.01204241719096899,
-0.0033662994392216206,
0.007438298314809799,
-0.04277448356151581,
-0.019110791385173798,
-0.006180559750646353,
-0.010158655233681202,
-0.0101301996037364,
0.002697592368349433,
-0.017983950674533844,
0.0015636361204087734,
-0.01766524650156498,
-0.003963867202401161,
-0.031050769612193108,
0.0005801388761028647,
-0.0224002618342638,
-0.011251350864768028,
-0.00907165091484785,
0.002084373962134123,
-0.006983008235692978,
0.00446753203868866,
-0.008758638985455036,
0.0004047811380587518,
-0.008451318368315697,
-0.015343268401920795,
-0.012554618529975414,
-0.014409923925995827,
-0.030162952840328217,
0.014034310355782509,
-0.01341966912150383,
-0.016663609072566032,
-0.012622911483049393,
-0.005244370084255934,
-0.011962741613388062,
-0.003707766765728593,
-0.0277043879032135,
0.010107435286045074,
-0.020192105323076248,
-0.04024762287735939,
-0.0006964512285776436,
0.041659023612737656,
0.006766745820641518,
0.004043543245643377,
-0.06310317665338516,
0.0041203731670975685,
-0.018575826659798622,
0.020078282803297043,
-0.02065877802670002,
-0.014671715907752514,
-0.026156403124332428,
-0.017335161566734314,
-0.048670485615730286,
-0.04090779647231102,
-0.014205044135451317,
-0.0191335566341877,
-0.02786373905837536,
0.003155727870762348,
-0.005614293273538351,
0.0021754319313913584,
-0.005363883916288614,
0.011285497806966305,
-0.02365230955183506,
-0.008394407108426094,
-0.004948431625962257,
0.004612655378878117,
0.00693178828805685,
0.05581853911280632,
-0.01700507663190365,
0.0007725699688307941,
-0.007404151372611523,
0.04282001033425331,
-0.028023092076182365,
0.019759580492973328,
0.025678347796201706,
-0.03344104066491127,
-0.005924459546804428,
0.02658892795443535,
0.00446753203868866,
-0.06515198200941086,
0.009765967726707458,
0.0011239969171583652,
0.0013317228294909,
0.022673435509204865,
-0.015616442076861858,
0.012622911483049393,
0.0032354036811739206,
-0.012053798884153366,
0.003551261033862829,
0.008650507777929306,
-0.0362638384103775,
0.01319202408194542,
-0.00135804433375597,
-0.018780706450343132,
0.01106354407966137,
-0.0019933159928768873,
-0.004424848593771458,
0.027135275304317474,
0.02622469700872898,
0.01723272167146206,
0.011183056980371475,
-0.001287616672925651,
0.007301711477339268,
0.007830985821783543,
-0.029070258140563965,
-0.01426195539534092,
0.01961161196231842,
0.006078119855374098,
0.00020096779917366803,
0.01917908526957035,
0.0031756467651575804,
-0.00874156504869461,
0.026907632127404213,
0.004134600982069969,
-0.01664084382355213,
-0.008758638985455036,
0.004239886999130249,
-0.0019292908255010843,
-0.014227808453142643,
-0.008354568853974342,
0.1489708423614502,
-0.008519611321389675,
0.009987921454012394,
0.01617417298257351,
0.004658184479922056,
-0.019065262749791145,
0.013339993543922901,
-0.016663609072566032,
0.03243940323591232,
-0.020305927842855453,
0.016982311382889748,
0.00708544859662652,
0.025177529081702232,
0.03473861515522003,
0.010352153331041336,
-0.030094660818576813,
-0.008650507777929306,
0.025951523333787918,
-0.014045692048966885,
-0.021410005167126656,
0.042273662984371185,
0.001502456609159708,
-0.007495209574699402,
0.028227971866726875,
-0.04753226041793823,
-0.02538241073489189,
-0.00003579182885005139,
-0.006681378930807114,
-0.0007533624302595854,
0.0012698319042101502,
0.006607394199818373,
0.020806746557354927,
-0.0004624037828762084,
-0.00038486221455968916,
-0.01849615015089512,
-0.03111906163394451,
-0.01415951456874609,
-0.0071992711164057255,
-0.005756571423262358,
0.005170385353267193,
0.01161558274179697,
-0.004288261290639639,
0.011177366599440575,
0.013920487836003304,
0.02515476569533348,
0.00038059387588873506,
-0.04279724881052971,
-0.02617916651070118,
0.0038614273071289062,
-0.02431247942149639,
0.012691205367445946,
-0.00538664823397994,
0.005503316409885883,
-0.03323616087436676,
-0.022195380181074142,
0.001234973780810833,
0.022081559523940086,
0.004641111008822918,
-0.0127936452627182,
-0.02963937073945999,
-0.004379319492727518,
0.038449227809906006,
0.03635489568114281,
-0.00393541157245636,
0.005207377951592207
] | 2025-01-08 | 137 | 39766419 | [
"CAR)-T cells",
"myeloid cell activation",
"solid CNS tumours",
"solid tumours",
"focal neurological deficits",
"attention deficits",
"patients",
"systemic B-cell malignancies",
"local inflammation",
"chimeric antigen receptor",
"large B-cell lymphomas",
"several CNS cancers",
"available data",
"ongoing challenges",
"brain oedema",
"response rates",
"mechanical complications",
"vigilance impairment",
"motor symptoms",
"CAR-T cells",
"solid and haematological CNS malignancies",
"neurotoxicity",
"future perspectives",
"CNS",
"Early studies",
"Tumour inflammation-associated neurotoxicity",
"primary or secondary central nervous system",
"Common toxicities",
"adult and paediatric patients",
"blood-brain barrier dysfunction"
] | [
"CAR-T cells",
"CNS tumours",
"ICANS",
"TIAN",
"neurotoxicity"
] | 0 | 10.3390/brainsci14121220
10.1056/NEJMoa1707447
10.1056/NEJMoa1709866
10.1056/NEJMoa1709919
10.1056/NEJMoa1804980
10.1016/S1470-2045(18)30864-7
10.1016/S0140-6736(20)31366-0
10.1056/NEJMoa1914347
10.1016/S0140-6736(21)00933-8
10.1056/NEJMoa2024850
10.1038/s41591-021-01622-0
10.1056/NEJMra1706169
10.1038/nature22395
10.1038/s41577-021-00547-6
10.1038/s41591-018-0036-4
10.1016/j.bbmt.2018.12.758
10.1182/bloodadvances.2019000952
10.1016/S1470-2045(19)30729-6
10.1038/s41571-023-00729-2
10.1016/j.ccell.2020.07.005
10.1038/s41586-023-05707-3
10.1007/s00262-020-02735-0
10.1172/JCI166028
10.1158/1078-0432.CCR-22-2293
10.1158/2326-6066.CIR-17-0189
10.1016/j.canlet.2023.216355
10.1016/j.eururo.2019.08.014
10.1158/2326-6066.CIR-19-0293
10.1038/s41591-022-01800-8
10.1158/1078-0432.CCR-15-0428
10.1056/NEJMoa1610497
10.1016/j.ymthe.2017.10.002
10.1038/s41591-021-01404-8
10.1093/neuonc/noac024
10.1158/2159-8290.CD-22-0750
10.21203/rs.3.rs-3454977/v1
10.1038/s43018-023-00709-6
10.1038/s41591-024-02875-1
10.1001/jamaoncol.2017.0184
10.1126/scitranslmed.aaa0984
10.1097/CJI.0000000000000260
10.3389/fonc.2021.669071
10.1186/s40425-018-0340-z
10.1038/s41591-018-0006-x
10.1158/1078-0432.CCR-18-0432
10.1038/s41591-020-0821-8
10.1038/s41586-022-04489-4
10.1186/s12943-022-01711-9
10.1007/s11060-024-04564-y
10.1016/j.omto.2019.07.002
10.1038/s41392-021-00505-7
10.1056/NEJMoa2314390
10.1038/s41591-024-02893-z
10.3389/fonc.2021.694941
10.1016/j.jtct.2023.10.017
10.1002/ajh.25951
10.1038/s41591-022-01969-y
10.1016/j.annonc.2021.12.003
10.1038/nbt0102-70
10.1136/jitc-2022-006365
10.1038/s41408-023-00963-y
10.1186/s13613-024-01247-9
10.1182/blood.2022017414
10.1038/nrclinonc.2017.148
10.1158/2159-8290.CD-17-1319
10.3389/fimmu.2022.855730
10.1016/j.ejca.2023.113505
10.3389/fonc.2021.698607
10.3389/fimmu.2020.577027
10.1182/blood-2018-12-893396
10.1158/2159-8290.CD-17-0698
10.1002/ana.25502
10.1148/radiol.2021210760
10.1097/HS9.0000000000000533
10.1186/s42466-021-00166-5
10.1136/jitc-2021-003847
10.1016/j.jtct.2023.04.001
10.1136/jitc-2022-005956
10.21873/anticanres.15876
10.3389/fimmu.2024.1380451
10.1093/brain/awz053
10.1016/j.jtct.2022.03.006
10.1038/s41591-023-02276-w
10.1016/j.jtct.2023.10.006
10.1016/j.trecan.2023.07.007
10.1093/neuonc/noad118
10.1182/blood.2021014738
10.1056/NEJMc1704610
10.1056/NEJMoa1215134
10.1200/JCO.2014.56.2025
10.1182/bloodadvances.2020004106
10.1182/blood.2021012932
10.1182/blood.2019001694
10.1002/ajh.27316
10.1182/blood-2019-129097
10.1212/WNL.0000000000200608
10.1182/bloodadvances.2021005292
10.1038/s41409-020-01099-4
10.1038/s41408-021-00523-2
10.1182/bloodadvances.2023010336
10.1089/hum.2021.249
10.1155/2022/2900310
10.3389/fimmu.2022.965224
10.1186/s13045-023-01508-3
10.1097/CJI.0000000000000416
10.1182/bloodadvances.2022008525
10.1007/s00262-023-03619-9
10.3389/fneur.2023.1108297
10.1001/jama.2023.0023
10.3390/ijms241311110
10.1038/mt.2012.210
10.1158/1078-0432.CCR-09-1322
10.1093/neuonc/nou348
10.3109/14653249.2012.666633
10.3389/fonc.2022.873722
10.1038/s41591-020-0827-2
10.1007/s00234-010-0802-6
10.1007/s11060-023-04324-4
10.1093/noajnl/vdad135
10.3389/fradi.2022.883293
10.1182/blood.2019001463
10.1200/JCO.20.02477
10.1038/s41591-023-02404-6
10.1186/s12943-023-01723-z
10.1016/j.intimp.2023.111093
10.1182/blood-2004-11-4564
10.1056/NEJMoa1106152
10.1182/blood-2011-02-337360
10.1038/s41571-022-00704-3
10.1126/scitranslmed.abb6295
10.1038/s41598-021-01418-9
10.1126/sciadv.aay9209
10.1038/s41551-021-00779-w
10.1038/s41571-020-00447-z
10.1093/brain/awad195
10.3389/fimmu.2023.1188818
10.1136/jitc-2023-007329 | [
"Palazzo",
"Pieri",
"Berzero",
"Filippi"
] | [
"Neurology Unit, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.\nFaculty of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.",
"Neurology Unit, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.\nFaculty of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.",
"Neurology Unit, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.\nFaculty of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.",
"Neurology Unit, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.\nFaculty of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.\nNeurorehabilitation Unit, Neurophysiology Unit, Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS Ospedale San Raffaele, 20132 Milan, Italy."
] | [
"39766419",
"29226797",
"29385370",
"29385376",
"30501490",
"30518502",
"32888407",
"32242358",
"34175021",
"33626253",
"34921238",
"29972754",
"28541315",
"34002066",
"29808007",
"30592986",
"32084260",
"32007196",
"36721024",
"32735779",
"36813894",
"33025047",
"36951942",
"36692420",
"29109077",
"37597651",
"31471138",
"31953246",
"35534566",
"26059190",
"28029927",
"29103912",
"34253928",
"35100373",
"36259971",
"38216766",
"38454126",
"28426845",
"28724573",
"30882547",
"34026647",
"29712574",
"29662203",
"30655315",
"32341579",
"35130560",
"36617554",
"38263486",
"31485480",
"32547742",
"33767145",
"38477966",
"38480922",
"34235085",
"37890589",
"32744738",
"36138152",
"34923107",
"11753365",
"37045474",
"38114481",
"38291184",
"36989488",
"28925994",
"29880584",
"35911769",
"38262306",
"34381720",
"33391257",
"30808634",
"29025771",
"31074527",
"34751616",
"33615147",
"35000613",
"34996813",
"37031746",
"36455991",
"35896259",
"38765003",
"30891590",
"35288347",
"37024595",
"37821079",
"37541803",
"37402650",
"35167655",
"28834486",
"23527958",
"25154820",
"34492703",
"34871363",
"31320380",
"38586986",
"35351785",
"34551065",
"33168933",
"34267187",
"37450376",
"35152726",
"36483984",
"36059496",
"37946255",
"35404315",
"36260735",
"38349430",
"36970518",
"36809318",
"37446288",
"10353730",
"23070117",
"20068073",
"25586468",
"22424217",
"36505819",
"32341580",
"21107549",
"37129737",
"38024243",
"37492665",
"31697826",
"33417474",
"37400640",
"36717905",
"37897950",
"15728125",
"22047558",
"21653320",
"36418477",
"33408186",
"34754016",
"32128416",
"34385696",
"33293629",
"37289981",
"37342332",
"38350684"
] | [] | 6.14942 | 4.231815 |
39764559 | 67 | Loading of CAR-T cells with magnetic nanoparticles for controlled targeting suppresses inflammatory cytokine release and switches tumor cell death mechanism. | Therapies against hematological malignancies using chimeric antigen receptors (CAR)-T cells have shown great potential; however, therapeutic success in solid tumors has been constrained due to limited tumor trafficking and infiltration, as well as the scarcity of cancer-specific solid tumor antigens. Therefore, the enrichment of tumor-antigen specific CAR-T cells in the desired region is critical for improving therapy efficacy and reducing systemic on-target/off-tumor side effects. Here, we functionalized human CAR-T cells with superparamagnetic iron oxide nanoparticles (SPIONs), making them magnetically controllable for site-directed targeting. SPION-loaded CAR-T cells maintained their specific cytolytic capacity against melanoma cells expressing the CAR-specific antigen chondroitin sulfate proteoglycan (CSPG4). Importantly, SPIONs suppressed cytokine release in the loaded CAR-T cells, shifting the cell death phenotype in the tumor cells from pyroptosis to apoptosis. Furthermore, SPION-loaded CAR-T cells could be enriched in a dynamic flow model through an external magnetic field and be detected in MRI. These results demonstrate that lytic cytotoxicity is retained after SPION-functionalization and provides a basis for future site-specific immunotherapies against solid tumors with reduced systemic adverse side effects. | [
0.020637188106775284,
-0.014680649153888226,
-0.014862876385450363,
0.04380277544260025,
-0.039474885910749435,
-0.042253848165273666,
-0.007095457520335913,
-0.001364565803669393,
0.004003295674920082,
-0.02927018515765667,
-0.015569005161523819,
0.012345868162810802,
-0.05931483581662178,
-0.011434733867645264,
0.029680196195840836,
-0.03680982068181038,
0.010609018616378307,
-0.009447322227060795,
0.007066984195262194,
-0.017550721764564514,
0.03608091175556183,
0.019885502755641937,
-0.0007894123555161059,
-0.024395616725087166,
-0.028951287269592285,
0.016434581950306892,
0.04592116177082062,
0.032709717750549316,
-0.027037905529141426,
-0.01717487908899784,
0.04081881046295166,
-0.02544342167675495,
-0.027447916567325592,
-0.04669562727212906,
-0.004732203204184771,
0.04346109926700592,
0.023233920335769653,
-0.007738946005702019,
-0.026810122653841972,
-0.028404608368873596,
0.03234526142477989,
0.008684247732162476,
-0.0028643780387938023,
0.08263986557722092,
-0.022698629647493362,
0.004569907207041979,
-0.037948738783597946,
-0.06715058535337448,
0.03314250707626343,
-0.006087515037506819,
-0.01062040776014328,
-0.004811927210539579,
-0.03831319138407707,
0.017972121015191078,
-0.04170716553926468,
0.03510144352912903,
-0.015648730099201202,
0.0237350445240736,
-0.01624096743762493,
0.012391424737870693,
-0.010882358998060226,
-0.0193274337798357,
0.04801677167415619,
-0.017140710726380348,
-0.044076114892959595,
0.022038057446479797,
-0.07043067365884781,
-0.03644536808133125,
0.014350363053381443,
0.03808540850877762,
0.008445074781775475,
-0.030363546684384346,
0.022402511909604073,
-0.021183868870139122,
0.02241390012204647,
-0.01561456173658371,
-0.008331183344125748,
0.03093300573527813,
0.014088411815464497,
-0.005475346930325031,
0.01776711642742157,
-0.025466199964284897,
0.005600627977401018,
-0.05403025448322296,
-0.04043157771229744,
-0.024737292900681496,
0.014487032778561115,
-0.03004464879631996,
-0.04168438911437988,
0.00826854258775711,
-0.027334025129675865,
0.01972605474293232,
-0.008997449651360512,
0.019213542342185974,
-0.0028985454700887203,
0.01157709863036871,
-0.03651370108127594,
-0.06578388810157776,
0.033210840076208115,
0.04589838534593582,
0.017881007865071297,
-0.020193010568618774,
-0.04316497966647148,
-0.009794692508876324,
0.05539695546030998,
0.025192860513925552,
-0.011263895779848099,
0.01604735106229782,
0.019224930554628372,
-0.011440427973866463,
0.09211566299200058,
-0.01130375824868679,
-0.023552818223834038,
0.05808480456471443,
-0.020272735506296158,
-0.07676305621862411,
-0.012744489125907421,
0.0021696381736546755,
0.011878911405801773,
0.050476834177970886,
0.005381386261433363,
0.047743428498506546,
0.038449861109256744,
-0.013553121127188206,
-0.005774312652647495,
-0.04947458580136299,
0.06582944095134735,
-0.03564812242984772,
0.011423344723880291,
-0.0225164033472538,
0.0112582016736269,
0.008371044881641865,
0.016411803662776947,
-0.017789894714951515,
-0.05380247160792351,
0.0014549674233421683,
-0.05011237785220146,
-0.03097856231033802,
-0.015842344611883163,
0.011030417867004871,
0.017744338139891624,
-0.021616658195853233,
0.008689941838383675,
-0.005512361880391836,
-0.019247708842158318,
-0.05772034823894501,
-0.01414535753428936,
0.032618604600429535,
0.02769847773015499,
0.06578388810157776,
-0.016081517562270164,
0.0494290292263031,
0.06778838485479355,
0.04298275336623192,
-0.0021283524110913277,
-0.03195803239941597,
-0.022778354585170746,
0.07029400020837784,
-0.01397452037781477,
-0.05548807233572006,
-0.0035705070476979017,
0.030477438122034073,
-0.025785095989704132,
-0.04223106801509857,
0.006936009041965008,
-0.0035989799071103334,
0.004592685494571924,
0.00802936963737011,
-0.07740084826946259,
-0.02888295240700245,
-0.005495278164744377,
-0.07006622105836868,
-0.09293568134307861,
0.01510204840451479,
-0.0411149300634861,
0.006030569318681955,
0.03813096508383751,
0.008092010393738747,
-0.015830956399440765,
0.017015431076288223,
-0.02309725061058998,
0.03842708468437195,
0.01233447901904583,
0.008405212312936783,
-0.003917877096682787,
0.05143352225422859,
-0.021798884496092796,
0.03421308845281601,
-0.013883407227694988,
0.012004192918539047,
0.0009303534170612693,
-0.04040880128741264,
0.0455339290201664,
0.03881431370973587,
-0.015967626124620438,
0.0035135610960423946,
0.015398167073726654,
0.014578146860003471,
-0.02084219455718994,
-0.04366610571742058,
0.03685537725687027,
0.021525545045733452,
-0.03309694677591324,
0.02163943648338318,
-0.030090205371379852,
-0.003957739099860191,
-0.01409980095922947,
0.03646814450621605,
0.02476007118821144,
-0.01737988367676735,
0.06127377226948738,
-0.005415553692728281,
0.015113437548279762,
-0.001219353755004704,
-0.01382646057754755,
-0.027379581704735756,
-0.016776258125901222,
0.03416753187775612,
-0.011189866811037064,
0.023757822811603546,
-0.014236471615731716,
-0.002918476704508066,
-0.012277533300220966,
0.062184907495975494,
-0.04432667791843414,
0.028495721518993378,
0.00714670866727829,
-0.03352973610162735,
0.0002806364500429481,
-0.022243062034249306,
-0.008063537068665028,
0.03724261000752449,
0.03209470212459564,
-0.04537448287010193,
-0.024258946999907494,
-0.04065936058759689,
0.03583035245537758,
-0.018325185403227806,
0.04526058956980705,
-0.03145690634846687,
0.019054092466831207,
0.00797811895608902,
0.02343892678618431,
-0.018609914928674698,
-0.02710624225437641,
-0.005637642461806536,
-0.008872169069945812,
-0.01894020102918148,
0.012254754081368446,
-0.02378060109913349,
0.0013916150201112032,
-0.01899714767932892,
-0.014031466096639633,
-0.00022244486899580806,
0.012026971206068993,
0.016662366688251495,
0.014190915040671825,
-0.017197657376527786,
0.004843247588723898,
-0.02231139875948429,
0.02952074632048607,
0.03460032120347023,
-0.039178770035505295,
-0.045237813144922256,
-0.03503311052918434,
-0.014635092578828335,
-0.011708074249327183,
0.026536783203482628,
0.03220859169960022,
-0.005145060829818249,
0.054349154233932495,
0.0010933609446510673,
0.03936099633574486,
-0.05589808151125908,
-0.04929235950112343,
0.03243637457489967,
-0.031001340597867966,
0.045101139694452286,
-0.022345565259456635,
0.012129473499953747,
0.015398167073726654,
0.03186691924929619,
0.003533492097631097,
-0.020864972844719887,
-0.045010026544332504,
0.0005868985317647457,
-0.0006936720455996692,
-0.024942297488451004,
-0.009191066026687622,
-0.04040880128741264,
0.02011328749358654,
0.005090962164103985,
-0.0376981757581234,
0.01073999423533678,
-0.009783303365111351,
0.008052147924900055,
-0.029247406870126724,
0.003487935522571206,
-0.023165585473179817,
0.00240454007871449,
-0.021206647157669067,
0.016184020787477493,
0.01923632062971592,
-0.03958877921104431,
0.009373292326927185,
0.013325337320566177,
0.021263593807816505,
-0.017357105389237404,
0.050340164452791214,
0.01079124491661787,
0.006451969034969807,
-0.03097856231033802,
-0.014748984016478062,
0.001947549288161099,
0.006822117138653994,
0.007340324576944113,
0.0328008309006691,
-0.026536783203482628,
0.00974344089627266,
-0.045442815870046616,
-0.019156595692038536,
0.004063088912516832,
0.00373280281201005,
-0.01702681928873062,
0.019122429192066193,
-0.035944242030382156,
0.029452411457896233,
0.009919973090291023,
0.024190612137317657,
-0.01446425449103117,
0.011599876917898655,
-0.02428172528743744,
0.06382495164871216,
-0.005458263214677572,
0.004621158819645643,
-0.015398167073726654,
-0.02706068381667137,
-0.07890421897172928,
0.01277865655720234,
0.019714664667844772,
0.000745279248803854,
0.016958484426140785,
-0.05662698671221733,
0.02867794781923294,
-0.007687694393098354,
-0.003630300285294652,
-0.013803682290017605,
0.014908432960510254,
0.022425290197134018,
0.0014506963780149817,
0.03275527432560921,
0.04860900714993477,
0.011890300549566746,
0.03239081799983978,
-0.013484785333275795,
0.0148059306666255,
-0.024851184338331223,
0.007596581242978573,
0.0010008239187300205,
-0.015158995054662228,
0.009675106033682823,
0.005239021498709917,
-0.01785822957754135,
0.02710624225437641,
0.010836802423000336,
0.05990707129240036,
-0.011662517674267292,
0.0553058423101902,
-0.006457663606852293,
-0.03646814450621605,
-0.00974344089627266,
0.022618906572461128,
0.020876361057162285,
0.0012876888504251838,
-0.005387080833315849,
0.06350605189800262,
0.029452411457896233,
0.0178696196526289,
0.007744640577584505,
-0.029292963445186615,
0.049064576625823975,
-0.03954322263598442,
-0.014897043816745281,
-0.005529445596039295,
-0.0013432110426947474,
-0.012106695212423801,
0.05393914133310318,
0.0024330129381269217,
-0.07311851531267166,
0.035169780254364014,
0.0011125801829621196,
-0.06373383849859238,
0.03004464879631996,
-0.0009908584179356694,
-0.00922523345798254,
0.07790197432041168,
-0.020272735506296158,
0.0680617243051529,
0.03268693760037422,
-0.01997661590576172,
-0.00016647773736622185,
-0.012926716357469559,
-0.019372990354895592,
-0.03562534600496292,
0.031138010323047638,
-0.0420943982899189,
0.0494290292263031,
0.03289194405078888,
-0.002946949563920498,
-0.03097856231033802,
0.03015854023396969,
-0.0055009727366268635,
0.035511452704668045,
0.023848935961723328,
0.007271989714354277,
-0.02173054963350296,
-0.008621606975793839,
0.06136488541960716,
-0.028609612956643105,
0.0450328066945076,
0.003561965189874172,
-0.025329530239105225,
0.025215638801455498,
0.001564588164910674,
0.014122579246759415,
0.010643186047673225,
0.02428172528743744,
-0.03300583362579346,
0.03692371025681496,
-0.06965620815753937,
-0.027334025129675865,
0.06910952925682068,
-0.0073858811520040035,
-0.02055746503174305,
-0.020933307707309723,
-0.015796788036823273,
-0.024190612137317657,
0.02134331874549389,
-0.022915024310350418,
0.015193162485957146,
-0.012231975793838501,
-0.01805184595286846,
-0.020773859694600105,
-0.04034046456217766,
0.05398469790816307,
-0.03314250707626343,
-0.00740296533331275,
0.021571101620793343,
-0.03211747854948044,
-0.015534837730228901,
-0.02245945669710636,
-0.014350363053381443,
0.00866146944463253,
0.022356955334544182,
-0.01018192432820797,
-0.016275133937597275,
-0.008234375156462193,
-0.05840370059013367,
0.009014533832669258,
0.0034736990928649902,
0.05507805943489075,
-0.05535139888525009,
-0.02428172528743744,
-0.062276020646095276,
-0.0009574026917107403,
0.0305913295596838,
0.018974369391798973,
-0.026992348954081535,
-0.009680800139904022,
-0.026263441890478134,
0.032823607325553894,
0.0067253089509904385,
-0.02133192867040634,
0.004524350631982088,
-0.003268693806603551,
0.02064857818186283,
0.03248193487524986,
0.01414535753428936,
0.01057485118508339,
0.03478254750370979,
-0.0078015862964093685,
-0.015922069549560547,
-0.04097826033830643,
-0.01382646057754755,
0.032618604600429535,
0.05220798775553703,
-0.005062489304691553,
0.009897194802761078,
-0.025283973664045334,
0.052982453256845474,
-0.014999546110630035,
-0.011024723760783672,
0.011639739386737347,
-0.009521352127194405,
-0.022003890946507454,
-0.020147453993558884,
0.014304806478321552,
-0.01733432710170746,
-0.014589536003768444,
0.015580394305288792,
0.05453138053417206,
-0.003356959903612733,
-0.000033077551051974297,
0.014133968390524387,
0.010489432141184807,
0.04860900714993477,
0.004965681117027998,
0.06127377226948738,
0.012641986832022667,
0.03735649958252907,
0.011673906818032265,
0.010352762416005135,
0.03507866710424423,
-0.032322484999895096,
-0.022356955334544182,
-0.04920124635100365,
-0.04200328513979912,
0.0018037608824670315,
-0.026650674641132355,
0.0019760222639888525,
-0.012528094463050365,
-0.0017852535238489509,
-0.0016756326658651233,
0.03626313805580139,
0.03268693760037422,
-0.031980808824300766,
-0.03273249417543411,
-0.06036263704299927,
-0.054941389709711075,
-0.0367187075316906,
-0.005426942836493254,
-0.025192860513925552,
0.004948597401380539,
0.008946198970079422,
-0.011520152911543846,
0.0016414651181548834,
-0.05803924798965454,
0.019031314179301262,
-0.00846785306930542,
-0.027037905529141426,
0.026536783203482628,
0.0075908866710960865,
0.03430420160293579,
-0.012790045700967312,
-0.01286976970732212,
0.0071922652423381805,
0.020546074956655502,
-0.037607062608003616,
-0.0009132696432061493,
-0.010563462041318417,
0.017265992239117622,
-0.046422284096479416,
0.018382132053375244,
-0.01485148724168539,
0.0269240140914917,
-0.007049900479614735,
-0.0006356584490276873,
-0.0391559898853302,
0.008205901831388474,
0.011292369104921818,
-0.02182166278362274,
-0.015569005161523819,
0.017949342727661133,
-0.030705220997333527,
-0.006901841145008802,
0.02769847773015499,
0.02658233977854252,
-0.03118356689810753,
-0.031046897172927856,
0.03833597153425217,
-0.021525545045733452,
0.005444026552140713,
0.019691886380314827,
-0.005324440076947212,
0.06446274369955063,
-0.0035277975257486105,
-0.049019016325473785,
-0.01057485118508339,
-0.005318745505064726,
0.021912775933742523,
-0.024896740913391113,
-0.005164991598576307,
0.004188369959592819,
0.060225967317819595,
-0.005418401211500168,
0.006525998469442129,
-0.0533469058573246,
0.008877863176167011,
-0.005651879124343395,
0.0010577698703855276,
0.023416148498654366,
-0.01756211183965206,
0.05006682127714157,
-0.01218641921877861,
-0.049656812101602554,
0.015671508386731148,
-0.004524350631982088,
-0.007431438192725182,
-0.014395919628441334,
0.0071922652423381805,
-0.005105198826640844,
-0.028062932193279266,
-0.008946198970079422,
-0.0464906208217144,
-0.0016969874268397689,
0.0352381132543087,
-0.004501572344452143,
-0.034281421452760696,
0.03220859169960022,
0.016411803662776947,
0.02290363423526287,
0.01659403182566166,
-0.015933459624648094,
-0.00022885127691552043,
0.020398017019033432,
0.0033484180457890034,
-0.0015631645219400525,
0.004791996441781521,
0.004461710341274738,
-0.015477892011404037,
-0.03024965524673462,
-0.0019902586936950684,
-0.011241117492318153,
0.02177610620856285,
-0.0117422416806221,
-0.029611861333251,
-0.01644597202539444,
-0.013165888376533985,
-0.010244565084576607,
0.005950844846665859,
0.008826612494885921,
-0.04619450122117996,
-0.010967777110636234,
0.009435933083295822,
-0.014646481722593307,
-0.03469143435359001,
-0.01678764633834362,
-0.026650674641132355,
0.028313493356108665,
0.002848717849701643,
-0.019054092466831207,
0.0156601183116436,
-0.023085862398147583,
-0.026400111615657806,
0.03469143435359001,
-0.0020742539782077074,
-0.02247084677219391,
0.018621305003762245,
-0.004205453675240278,
-0.0037100245244801044,
-0.014908432960510254,
-0.0033939748536795378,
0.009538435377180576,
-0.008735498413443565,
-0.0010271613718941808,
0.0007395846769213676,
0.025580091401934624,
-0.0220266692340374,
0.05735589563846588,
0.04213995486497879,
-0.04879123345017433,
0.016799036413431168,
-0.007476994767785072,
0.020534686744213104,
0.002878614468500018,
-0.020375236868858337,
0.0002092761278618127,
0.008120483718812466,
0.018678249791264534,
0.017436830326914787,
0.09412015974521637,
-0.0067708659917116165,
0.006053347606211901,
-0.02952074632048607,
0.0021667908877134323,
-0.00664558494463563,
-0.006856284569948912,
-0.0229947492480278,
-0.026536783203482628,
0.017710169777274132,
0.005059641785919666,
-0.018268240615725517,
-0.008228680118918419,
-0.06523720920085907,
-0.0005812039598822594,
0.008217290975153446,
-0.00417128624394536,
0.029816865921020508,
0.01678764633834362,
-0.011588487774133682,
0.0039207241497933865,
-0.002773264655843377,
-0.010318594053387642,
-0.02343892678618431,
0.02731124684214592,
0.006315298844128847,
-0.030181318521499634,
-0.011286674067378044,
-0.016457360237836838,
-0.014190915040671825,
0.024145055562257767,
0.011901689693331718,
0.028746282681822777,
-0.038745980709791183,
0.003590438049286604,
-0.032231371849775314,
0.0008072079508565366,
-0.02790348418056965,
0.001743967761285603,
0.0366959273815155,
-0.0046353950165212154,
0.001527573331259191,
-0.017687391489744186,
-0.0011759325861930847,
0.009521352127194405,
0.0010122130624949932,
0.026126772165298462,
0.04815344139933586,
0.008644385263323784,
0.021115534007549286,
-0.01233447901904583,
-0.0018279629293829203,
0.0075908866710960865,
-0.012596430256962776,
0.029543524608016014,
0.005281731020659208,
-0.03503311052918434,
0.054895833134651184,
-0.01966910809278488,
0.01929326541721821,
0.014179525896906853,
-0.0425955206155777,
-0.05462249368429184,
-0.030226875096559525,
-0.01668514497578144,
0.029839644208550453,
-0.03145690634846687,
-0.0021155397407710552,
-0.028518499806523323,
-0.007289073430001736,
0.04004434496164322,
-0.008057842962443829,
-0.0075453296303749084,
0.004732203204184771,
0.0010641762055456638,
0.03895098716020584,
0.02394005097448826,
-0.001988834934309125,
-0.01037554070353508,
-0.044417791068553925,
-0.017391273751854897,
0.007106846664100885,
0.0009410307393409312,
0.04243607446551323,
0.009823164902627468,
0.0020272734109312296,
0.000024713624952710234,
0.007835754193365574,
-0.009048701263964176,
-0.03211747854948044,
-0.0357392393052578,
-0.00024753663456067443,
-0.0013396519934758544,
0.01441869791597128,
0.0028828855138272047,
-0.00015820279077161103,
0.02603565901517868,
0.010449569672346115,
-0.03403086215257645,
0.030431881546974182,
0.002158249029889703,
-0.018757974728941917,
0.014065633527934551,
-0.003040910232812166,
-0.018666861578822136,
0.008502020500600338,
-0.05393914133310318,
0.007528245914727449,
-0.007932561449706554,
0.0028544124215841293,
-0.010956387966871262,
-0.0067253089509904385,
-0.00949857383966446,
-0.006002096459269524,
0.019691886380314827,
-0.016229577362537384,
0.0013303982559591532,
0.033301953226327896,
-0.012266144156455994,
-0.03735649958252907,
-0.0034196004271507263,
0.029497968032956123,
-0.056991443037986755,
0.004791996441781521,
-0.015398167073726654,
0.025830654427409172,
0.032573048025369644,
-0.09822026640176773,
-0.03177580237388611,
0.0060989041812717915,
-0.020432183519005775,
0.014543979428708553,
-0.0015361153054982424,
0.004515808541327715,
-0.008707026019692421,
0.04200328513979912,
-0.014088411815464497,
0.012026971206068993,
0.007505467627197504,
-0.01050082128494978,
0.005725908558815718,
0.008097704499959946,
-0.04478224366903305,
-0.020921917632222176,
-0.04195772856473923,
-0.012220586650073528,
0.021719161421060562,
-0.008929114788770676,
0.0010627525625750422,
-0.03195803239941597,
0.06004374101758003,
-0.0008741193450987339,
0.013450617901980877,
-0.03489643707871437,
0.02226584032177925,
-0.04829011112451553,
-0.038791537284851074,
0.0008819493814371526,
0.017015431076288223,
-0.015238719061017036,
0.04393944516777992,
0.0003044825280085206,
-0.03102411888539791,
0.033643629401922226,
-0.006782255135476589,
0.0001606941659701988,
0.03020409680902958,
-0.010853885672986507,
-0.005352913402020931,
0.01269893255084753,
0.010050948709249496,
-0.012277533300220966,
-0.01433897390961647,
-0.004342123866081238,
-0.01987411454319954,
0.005928066559135914,
0.0006466917111538351,
0.022778354585170746,
-0.011958636343479156,
-0.030568551272153854,
0.018769362941384315,
-0.012881158851087093,
-0.03469143435359001,
-0.022402511909604073,
0.029611861333251,
0.009213844314217567,
0.02854127809405327,
-0.03617202490568161,
0.03694649040699005,
0.0381765216588974,
-0.011981414631009102,
-0.009538435377180576,
-0.0008136143442243338,
-0.03024965524673462,
-0.0038466944824904203,
-0.009999697096645832,
0.014828708954155445,
-0.0019760222639888525,
0.0005591374356299639,
-0.032709717750549316,
0.02731124684214592,
0.01301782950758934,
-0.008234375156462193,
-0.005765771027654409,
-0.00536999711766839,
-0.023279478773474693,
0.0059565394185483456,
0.01370117999613285,
-0.025147302076220512,
0.004586990922689438,
0.011167088523507118,
-0.010580545291304588,
-0.012858380563557148,
0.029201850295066833,
0.015512059442698956,
-0.00834826659411192,
-0.016172630712389946,
-0.0035135610960423946,
-0.028769060969352722,
-0.013097553513944149,
-0.020637188106775284,
-0.004629700444638729,
-0.01429341733455658,
-0.02731124684214592,
0.0033170979004353285,
0.0022365497425198555,
0.0006253370083868504,
0.060225967317819595,
-0.04234496131539345,
-0.019953837618231773,
-0.03610369190573692,
-0.03343862295150757,
-0.012687543407082558,
0.03168468922376633,
0.0013282627332955599,
0.015136216767132282,
-0.004450320731848478,
0.042504407465457916,
-0.006081820465624332,
0.005392775405198336,
-0.02031829208135605,
-0.011616960167884827,
0.013405061326920986,
0.024828406050801277,
-0.0075738029554486275,
0.028154045343399048,
-0.007727556861937046,
0.05539695546030998,
0.0016912927385419607,
0.013370893895626068,
-0.03920154646039009,
-0.002871496370062232,
-0.007693388964980841,
-0.03983934223651886,
0.02510174550116062,
-0.019111039116978645,
-0.01206113863736391,
-0.0043705967254936695,
-0.0022821063175797462,
0.008536187931895256,
-0.026012880727648735,
-0.018575748428702354,
0.026605118066072464,
0.02055746503174305,
0.0028117031324654818,
-0.013792293146252632,
0.03605813533067703,
-0.01042109727859497,
-0.03421308845281601,
0.004604074638336897,
-0.01329116988927126,
0.02089913934469223,
-0.009003144688904285,
-0.005407011602073908,
-0.019851336255669594,
-0.01397452037781477,
0.01874658465385437,
-0.033506959676742554,
0.03343862295150757,
0.037219829857349396,
0.04043157771229744,
0.020534686744213104,
0.00859313365072012,
0.02070552483201027,
-0.009487184695899487,
-0.04737897589802742,
-0.000575865269638598,
-0.03897376358509064,
0.046126168221235275,
-0.046627290546894073,
-0.035306449979543686,
0.01619540899991989,
-0.021320538595318794,
-0.009919973090291023,
-0.008245764300227165,
0.016092907637357712,
0.03300583362579346,
-0.007254905998706818,
-0.06564721465110779,
0.017687391489744186,
-0.025671204552054405,
-0.016081517562270164,
0.00764783238992095,
0.044030558317899704,
-0.029475189745426178,
0.019270487129688263,
0.023325035348534584,
-0.013131720945239067,
-0.009458711370825768,
0.01005664374679327,
0.0058882045559585094,
0.0474700890481472,
-0.024851184338331223,
-0.024691736325621605,
-0.015409556217491627,
0.0049799177795648575,
0.010643186047673225,
-0.02658233977854252,
-0.011093058623373508,
-0.01441869791597128,
0.030409103259444237,
0.01737988367676735,
-0.007744640577584505,
-0.014635092578828335,
0.01054637786000967,
-0.032618604600429535,
-0.027539029717445374,
-0.019839946180582047,
0.02701512724161148,
0.030272433534264565,
-0.009777608327567577,
-0.034486427903175354,
0.01624096743762493,
0.004700882826000452,
-0.044759467244148254,
-0.02079663798213005,
0.024053942412137985,
0.006662668660283089,
0.03118356689810753,
-0.008063537068665028,
0.03680982068181038,
0.027584586292505264,
-0.0020884904079139233,
0.0023547124583274126,
0.002703505801036954,
-0.04227662459015846,
-0.024258946999907494,
-0.021468598395586014,
-0.010335678234696388,
-0.01620679907500744,
-0.005865426268428564,
-0.02236834354698658,
0.001669938093982637,
0.031388573348522186,
-0.002902816515415907,
-0.021605268120765686,
0.015193162485957146,
0.003738497383892536,
0.002230855170637369,
0.019555216655135155,
0.020352458581328392,
0.037470392882823944,
-0.0057999384589493275,
-0.025671204552054405,
-0.03742483630776405,
0.017414052039384842,
-0.0025995797477662563,
0.021400263532996178,
0.0011253930861130357,
0.002001647837460041,
-0.04457724094390869,
-0.0005929490434937179,
0.013632845133543015,
0.028951287269592285,
-0.03275527432560921,
-0.015455113723874092,
0.017140710726380348,
-0.015033713541924953,
0.025283973664045334,
0.013268391601741314,
0.004262399394065142,
0.04605783149600029,
0.018313797190785408,
0.023256700485944748,
0.0328008309006691,
0.01133223157376051,
0.022402511909604073,
-0.01010789442807436,
-0.021707771345973015,
0.0006495389970950782,
-0.023176975548267365,
0.03583035245537758,
-0.018291018903255463,
0.013348115608096123,
-0.01819990575313568,
0.030796334147453308,
0.03020409680902958,
0.011554320342838764,
-0.014190915040671825,
-0.025466199964284897,
0.0017937953816726804,
-0.0005705265793949366,
-0.018974369391798973,
0.00019539556524250656,
-0.0020272734109312296,
0.0034936300944536924,
0.010028170421719551,
-0.01634346880018711,
0.015227329917252064,
-0.0034423787146806717,
0.01736849546432495,
0.012436981312930584,
0.012118084356188774,
-0.028905730694532394,
-0.0028971219435334206,
0.017459608614444733,
-0.010124978609383106,
-0.0357164591550827,
-0.003880862146615982,
-0.012129473499953747,
-0.014304806478321552,
-0.004407611675560474,
-0.010831107385456562,
-0.019839946180582047,
0.0006972312112338841,
-0.03245915472507477,
-0.020694134756922722,
0.00039577390998601913,
0.002190992934629321,
0.004515808541327715,
0.002424471080303192,
-0.01737988367676735,
-0.05858592689037323,
-0.0420943982899189,
-0.051023513078689575,
0.035693682730197906,
-0.011531542055308819,
-0.028564056381583214,
0.005828411318361759,
0.01919076405465603,
-0.034828104078769684,
0.02892850898206234,
0.00878105591982603,
-0.004863178823143244,
0.002539786510169506,
0.0031149399001151323,
0.01238003559410572,
0.004262399394065142,
0.010614712722599506,
0.02017023228108883,
-0.019054092466831207,
-0.025420643389225006,
-0.014965378679335117,
0.005876815412193537,
-0.018177127465605736,
-0.013621455989778042,
-0.026536783203482628,
0.028062932193279266,
-0.008177429437637329,
0.007471300195902586,
0.004968528635799885,
-0.008154651150107384,
-0.0026565254665911198,
0.010341372340917587,
-0.03929265961050987,
-0.02128637209534645,
0.009316346608102322,
-0.007773113436996937,
0.02687845751643181,
0.0031377181876450777,
0.023757822811603546,
0.0018906034529209137,
0.02173054963350296,
-0.021958332508802414,
-0.0027148951776325703,
-0.003880862146615982,
0.004467404913157225,
0.042026061564683914,
0.01201558206230402,
-0.022550569847226143,
0.04266385734081268,
0.024873962625861168,
-0.012960883788764477,
-0.0027362497057765722,
0.0016471596900373697,
-0.007294768001884222,
-0.004063088912516832,
0.001215794705785811,
-0.012129473499953747,
0.038882650434970856,
-0.020181622356176376,
0.0008605946786701679,
0.022208895534276962,
-0.03699204698204994,
-0.013108942657709122,
-0.02119525894522667,
-0.01742544025182724,
0.005315898451954126,
0.022345565259456635,
-0.007841448299586773,
0.015625951811671257,
0.028769060969352722,
0.024099498987197876,
0.06172933802008629,
0.023085862398147583,
-0.021069977432489395,
0.03906487673521042,
0.025238417088985443,
-0.011132920160889626,
-0.006486136466264725,
-0.019464103505015373,
-0.016912927851080894,
-0.010398318991065025,
-0.022721407935023308,
-0.0274023599922657,
0.005836953409016132,
0.009213844314217567,
-0.014897043816745281,
-0.017163489013910294,
0.008143262006342411,
-0.012938105501234531,
-0.015876512974500656,
-0.0030323683749884367,
-0.011719463393092155,
0.013131720945239067,
-0.031388573348522186,
-0.002075677504763007,
-0.02555731311440468,
-0.005910982843488455,
0.003462309716269374,
-0.01865547150373459,
-0.004450320731848478,
0.04004434496164322,
0.010318594053387642,
0.010848191566765308,
0.011924467980861664,
0.012220586650073528,
-0.010734299197793007,
0.0007609393796883523,
-0.06637612730264664,
0.013872018083930016,
-0.01318866666406393,
-0.0011659669689834118,
0.010113589465618134,
-0.009709273464977741,
0.013837849721312523,
-0.010609018616378307,
-0.010557767003774643,
0.00720934895798564,
-0.02084219455718994,
-0.009145509451627731,
-0.009185370989143848,
-0.00650891475379467,
0.01785822957754135,
0.004985612351447344,
-0.04997570812702179,
0.03753872588276863,
-0.00537284417077899,
0.013234224170446396,
0.0069644819013774395,
-0.008650080300867558,
-0.034873660653829575,
-0.010643186047673225,
-0.013951742090284824,
-0.005842647980898619,
-0.0014720511389896274,
0.01433897390961647,
-0.013029218651354313,
-0.010028170421719551,
0.02103581093251705,
0.005458263214677572,
0.008376739919185638,
-0.018666861578822136,
-0.018336575478315353,
-0.0022579042706638575,
-0.004717966541647911,
0.00917967688292265,
0.012038360349833965,
0.04653617739677429,
-0.01402007695287466,
-0.02021578885614872,
-0.03191247582435608,
-0.0115030687302351,
-0.027766814455389977,
-0.02931574173271656,
0.01698126271367073,
0.02231139875948429,
-0.024646179750561714,
0.005973623599857092,
-0.006093209609389305,
0.03489643707871437,
-0.0063209934160113335,
-0.011201255954802036,
-0.009134120307862759,
0.003932113293558359,
-0.009475795552134514,
-0.007681999821215868,
-0.00638932827860117,
0.005666115786880255,
0.0396343357861042,
0.007038511335849762,
0.02892850898206234,
-0.03863208740949631,
0.030522994697093964,
-0.01206113863736391,
0.011856133118271828,
-0.015181773342192173,
-0.022926414385437965,
0.003735650097951293,
0.014441476203501225,
-0.001981716835871339,
0.007864226587116718,
0.036149248480796814,
0.000799377856310457,
-0.011349314823746681,
0.056308090686798096,
0.013120331801474094,
0.004085867200046778,
-0.00043278871453367174,
-0.007602275814861059,
-0.001452831900678575,
-0.0015902138547971845,
0.04122881963849068,
0.013370893895626068,
-0.02888295240700245,
-0.0008933385834097862,
-0.0010385506320744753,
-0.00772186229005456,
0.015215940773487091,
0.023063084110617638,
-0.0015076423296704888,
-0.021206647157669067,
0.031092453747987747,
-0.0631415992975235,
-0.05904149264097214,
0.010455264709889889,
0.03177580237388611,
-0.040499914437532425,
-0.01333672646433115,
-0.007915478199720383,
-0.025853432714939117,
0.034623097628355026,
-0.02676456607878208,
-0.023871714249253273,
0.02177610620856285,
0.01782406121492386,
-0.0037840541917830706,
-0.007505467627197504,
0.034964773803949356,
0.009583992883563042,
-0.032231371849775314,
-0.011935857124626637,
-0.019543828442692757,
0.002583919558674097,
0.0195779949426651,
-0.04398500174283981,
0.014680649153888226,
0.028860174119472504,
0.003593285335227847,
-0.017698781564831734,
-0.020375236868858337,
-0.0018137264996767044,
0.03455476462841034,
-0.03548867627978325,
-0.009492878802120686,
0.0005762211512774229,
-0.00045129613135941327,
-0.03284638747572899,
0.013997298665344715,
0.0073517137207090855,
0.008143262006342411,
0.005836953409016132,
0.024190612137317657,
0.03703760355710983,
-0.003146260278299451,
-0.014646481722593307,
0.036582037806510925,
0.014430087059736252,
0.005526598077267408,
-0.002756180940195918,
-0.021764717996120453,
-0.008171734400093555,
-0.019760223105549812,
0.0183593537658453,
-0.023165585473179817,
-0.00966941099613905,
0.009538435377180576,
0.02359837479889393,
-0.01421369332820177,
0.023962829262018204,
-0.0015489280922338367,
-0.0008136143442243338,
-0.02065996639430523,
-0.015671508386731148,
0.003556270617991686,
-0.019441325217485428,
-0.013667012564837933,
-0.011935857124626637,
-0.001699834712781012,
-0.025192860513925552,
-0.0016300759743899107,
-0.06327826529741287,
0.02867794781923294,
-0.018245462328195572,
0.008752582594752312,
-0.00751116219907999,
0.013769514858722687,
-0.015056491829454899,
-0.011349314823746681,
-0.028313493356108665,
0.003251610090956092,
-0.013906185515224934,
-0.03813096508383751,
-0.005742992740124464,
-0.004128576721996069,
-0.009173981845378876,
-0.0033683490473777056,
-0.05252688378095627,
-0.02794904075562954,
0.0149312112480402,
-0.015728453174233437,
0.01218641921877861,
0.01756211183965206,
0.0021867218893021345,
-0.001618686830624938,
-0.024873962625861168,
-0.011195560917258263,
0.01465787086635828,
0.027857927605509758,
0.004117187578231096,
-0.02407672069966793,
-0.008644385263323784,
0.01717487908899784,
0.0113834822550416,
-0.02676456607878208,
-0.0342586450278759,
-0.003129176329821348,
-0.008684247732162476,
0.0067879497073590755,
0.009612465277314186,
-0.016628198325634003,
-0.0156601183116436,
0.01269893255084753,
-0.0305913295596838,
0.023131418973207474,
0.019851336255669594,
-0.03243637457489967,
0.038928207010030746,
0.024805627763271332,
-0.02599010244011879,
0.006987260188907385,
-0.01429341733455658,
0.013302559033036232,
-0.003342723473906517,
0.011485985480248928,
0.026855679228901863,
-0.0019503965741023421,
-0.009959835559129715,
0.02064857818186283,
-0.017265992239117622,
-0.03637703135609627,
0.020694134756922722,
-0.0008292744751088321,
0.005284578073769808,
0.018587136641144753,
-0.022379733622074127,
0.022721407935023308,
0.017607668414711952,
0.003376890905201435,
-0.010814023204147816,
0.02696957066655159,
-0.024304503574967384,
0.01693570613861084,
0.010347067378461361,
0.006708225235342979,
0.007676305249333382,
-0.023803379386663437,
-0.033552516251802444,
-0.0071410140953958035,
0.013769514858722687,
-0.0069189248606562614,
0.02378060109913349,
0.016571253538131714,
0.007118235807865858,
0.022698629647493362,
-0.052299100905656815,
-0.0056404899805784225,
0.03945210948586464,
-0.04252718761563301,
-0.021218037232756615,
0.024213390424847603,
0.012573651038110256,
0.03323362022638321,
0.020716913044452667,
0.020386626943945885,
0.006395022850483656,
-0.03788040205836296,
-0.010916526429355145,
0.0015944847837090492,
0.008416601456701756,
0.0003062620817217976,
0.11416511237621307,
-0.021206647157669067,
-0.010728605091571808,
0.0037982906214892864,
0.006212796084582806,
-0.010853885672986507,
0.02466895803809166,
0.014133968390524387,
0.025671204552054405,
0.0041598971001803875,
0.036878153681755066,
-0.006224185228347778,
0.020272735506296158,
0.03519255667924881,
0.024896740913391113,
-0.016309302300214767,
0.00866146944463253,
0.036240361630916595,
-0.011639739386737347,
0.0024572149850428104,
-0.0002836617059074342,
0.0036246057134121656,
0.005848342552781105,
0.04090992361307144,
-0.020568853244185448,
0.0005641201860271394,
-0.0026024270337074995,
-0.020147453993558884,
-0.00505110016092658,
0.008000897243618965,
0.02432728186249733,
-0.002918476704508066,
0.003749886527657509,
-0.015477892011404037,
0.012482537887990475,
-0.02428172528743744,
0.0012670459691435099,
-0.021502766758203506,
0.00409725634381175,
0.01708376593887806,
-0.00915120355784893,
-0.038928207010030746,
0.01329116988927126,
0.015990404412150383,
0.015500670298933983,
-0.0033313343301415443,
-0.04116048663854599,
-0.005916677415370941,
-0.0023959982208907604,
-0.03788040205836296,
-0.014840098097920418,
0.014874265529215336,
0.01693570613861084,
-0.009823164902627468,
-0.03259582445025444,
-0.0034537678584456444,
0.01987411454319954,
0.0030978561844676733,
-0.008000897243618965,
-0.019054092466831207,
-0.02774403616786003,
0.02530675195157528,
0.011167088523507118,
-0.0011901690158993006,
0.01942993700504303
] | 2025-01-07 | 79 | 39764559 | [
"CAR)-T cells",
"melanoma cells",
"solid tumors",
"limited tumor trafficking",
"tumor",
"reduced systemic adverse side effects",
"human CAR-T cells",
"cancer-specific solid tumor antigens",
"tumor-antigen specific CAR-T cells",
"chimeric antigen receptors",
"superparamagnetic iron oxide nanoparticles",
"the tumor cells",
"SPION-loaded CAR-T cells",
"therapy efficacy",
"the loaded CAR-T cells",
"lytic cytotoxicity",
"the cell death phenotype",
"future site-specific immunotherapies",
"great potential",
"therapeutic success",
"cytokine release",
"SPIONs",
"CAR",
"hematological malignancies",
"Therapies",
"the CAR-specific antigen chondroitin sulfate proteoglycan",
"their specific cytolytic capacity",
"infiltration",
"target",
"an external magnetic field"
] | [
"CAR‐T cell",
"adoptive T cell therapy",
"cancer",
"magnetic cell targeting",
"pyroptosis",
"superparamagnetic iron oxide nanoparticles (SPIONs)"
] | 0 | 10.1002/mco2.70039 | [
"Pfister",
"Carnell",
"Löffler",
"Boosz",
"Schaft",
"Dörrie",
"Stein",
"Lenz",
"Spiecker",
"Huber",
"Haddadin",
"Berking",
"Alexiou",
"Janko"
] | [
"Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.",
"Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.",
"Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.\nFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.",
"Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.\nFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.",
"Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.\nDepartment of Dermatology Universitätsklinikum Erlangen Erlangen Germany.\nComprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.\nDeutsches Zentrum Immuntherapie (DZI) Erlangen Germany.",
"Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.\nDepartment of Dermatology Universitätsklinikum Erlangen Erlangen Germany.\nComprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.\nDeutsches Zentrum Immuntherapie (DZI) Erlangen Germany.",
"Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.",
"Institute of Micro- and Nanostructure Research & Center for Nanoanalysis and Electron Microscopy Interdisciplinary Center for Nanostructured Films Friedrich-Alexander-University Erlangen Erlangen Germany.",
"Institute of Micro- and Nanostructure Research & Center for Nanoanalysis and Electron Microscopy Interdisciplinary Center for Nanostructured Films Friedrich-Alexander-University Erlangen Erlangen Germany.",
"Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.\nInstitute of Microwave and Photonics Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.",
"Chair of Robotics Science and Systems Intelligence Munich Institute of Robotics and Machine Intelligence (MIRMI), TUM School of Computation, Information and Technology Technical University of Munich Munich Germany.",
"Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Erlangen Germany.\nDepartment of Dermatology Universitätsklinikum Erlangen Erlangen Germany.\nComprehensive Cancer Center Erlangen European Metropolitan Area of Nuremberg (CCC ER-EMN) Erlangen Germany.\nDeutsches Zentrum Immuntherapie (DZI) Erlangen Germany.",
"Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany.",
"Department of Otorhinolaryngology Head and Neck Surgery Section of Experimental Oncology and Nanomedicine (SEON) Else Kröner-Fresenius-Stiftung Professorship Universitätsklinikum Erlangen Erlangen Germany."
] | [
"39764559",
"38572751",
"33167514",
"25675873",
"28344995",
"35658469",
"36765623",
"33824268",
"23550147",
"22262649",
"27626062",
"27207799",
"33972771",
"23242161",
"20926399",
"21279377",
"28769560",
"27698936",
"18182491",
"25652717",
"35101971",
"34439296",
"31749616",
"31749616",
"32024193",
"30763076",
"35025416",
"31387604",
"30670029",
"31543880",
"37662937",
"8562939",
"10571405",
"3718838",
"10468613",
"11936878",
"10197164",
"12812755",
"10752477",
"8361995",
"1694058",
"26515978",
"34503523",
"36179026",
"33869653",
"24938475",
"34002066",
"31426437",
"29346301",
"1672270",
"33504767",
"31953257",
"35236363",
"30299232",
"32753728",
"29123957",
"28681852",
"21779028",
"16954023",
"16194448",
"25214781",
"23160470",
"34429382",
"31316055",
"25520398",
"38143263",
"25711538",
"26369987",
"26375003",
"27573174",
"32188940",
"32299851",
"34794490",
"37752941",
"23669367",
"31779130",
"27987149",
"22770690",
"36497463"
] | [] | 9.707909 | 4.57403 |
39763668 | 68 | Efficacy and safety of chimeric antigen receptor T cells targeting BCMA and GPRC5D in relapsed or refractory multiple myeloma. | Clinical studies have demonstrated the high efficacy of using chimeric antigen receptor (CAR)-T cells targeting B-cell maturation antigen (BCMA) and orphan G protein-coupled receptor, class C group 5 member D (GPRC5D) to treat relapsed or refractory multiple myeloma (RRMM). In this study, we compared the efficacy and safety of BCMA CAR-T-cell therapy (BCMA CAR-T) and GPRC5D CAR T-cell therapy (GPRC5D CAR-T) in patients with RRMM.
We retrieved and included eligible clinical trials of BCMA or GPRC5D CAR-T for RRMM patients. The primary outcomes for efficacy were overall response rate (ORR), complete response rate (CRR), minimal residual disease (MRD) negativity, and relapse rate. The primary outcomes for safety were cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS).
We incorporated 18 early-phase, single-arm clinical trials, which included 503 and 133 patients receiving BCMA CAR-T and GPRC5D CAR-T, respectively. For the GPRC5D CAR-T cohort, the estimated ORR, CRR, MRD negativity rate, and relapse rate were found to be 89.8% [95% confidence interval (CI), 82.8%-96.9%], 50.5% (95% CI, 38.0%-62.9%), 78.8% (95% CI, 53.0%-100%), and 26.0% (95% CI, 7.4%-44.6%), respectively. In the BCMA CAR-T group, the ORR was 76.3% (95% CI, 67.9%-84.7%), the CRR was 34.3% (95% CI, 25.9%-42.7%), the MRD negativity rate was 76.5% (95% CI, 63.1%-90.0%), and the recurrence rate was 57.3% (95% CI, 47.7%-66.9%). These values were significantly lower than those observed in the GPRC5D CAR-T cohort. Both BCMA and GPRC5D CAR-T demonstrated acceptable safety. The estimated incidence of BCMA CAR-T resulting in grade 3-5 CRS and ICANS was only 5.4% (95% CI, 2.0%-10.4%) and 3.3% (95% CI, 0.6%-8.0%), respectively. The estimated incidence of GPRC5D CAR-T resulting in grade 3-5 CRS and ICANS was only 1.6% (95% CI, 0.0%-6.5%) and 2.7% (95% CI, 0.7%-6.2%), respectively.
GPRC5D CAR-T potentially demonstrates enhanced effectiveness relative to BCMA CAR-T in treating patients with RRMM. Therefore, GPRC5D CAR-T can be regarded as the preferred therapeutic option for RRMM, particularly among patients who have undergone relapse subsequent to BCMA CAR-T treatment. | [
0.034828707575798035,
0.026804447174072266,
0.05487716570496559,
0.036682337522506714,
-0.018902134150266647,
-0.014011969789862633,
0.004698094911873341,
0.0070791542530059814,
0.035389672964811325,
-0.011030309833586216,
0.002341425744816661,
-0.032145824283361435,
-0.036365266889333725,
0.018353363499045372,
0.021585017442703247,
-0.010127885267138481,
0.014890003949403763,
-0.017560692504048347,
0.015426580794155598,
0.05926733836531639,
0.029877567663788795,
0.017036311328411102,
-0.009633990935981274,
-0.0016280225245282054,
-0.035023827105760574,
0.004289565142244101,
0.015402191318571568,
-0.006201119627803564,
-0.015597309917211533,
-0.017780201509594917,
0.008201087825000286,
-0.028292227536439896,
-0.040438372641801834,
-0.033657994121313095,
-0.043096866458654404,
0.007323052734136581,
0.035145774483680725,
0.012890036217868328,
-0.0045639509335160255,
-0.018341168761253357,
0.014646105468273163,
0.016816802322864532,
0.007951091043651104,
0.07853531837463379,
-0.05590153858065605,
-0.007073056884109974,
0.006658429279923439,
-0.06165754422545433,
0.042389560490846634,
-0.015426580794155598,
-0.05180404335260391,
0.022389883175492287,
-0.016621682792901993,
0.007158421445637941,
-0.04695046320557594,
0.021585017442703247,
-0.018755795434117317,
0.010103495791554451,
0.032316554337739944,
-0.012042488902807236,
0.018658235669136047,
-0.007298662792891264,
-0.004326149821281433,
-0.030999500304460526,
-0.0467553436756134,
-0.026023970916867256,
-0.04924311116337776,
0.002685932442545891,
0.034438468515872955,
0.015329021029174328,
-0.020755764096975327,
-0.010347394272685051,
0.028609296306967735,
0.0022530124988406897,
0.022511832416057587,
0.028097108006477356,
0.040511541068553925,
0.024341071024537086,
-0.0006871078512631357,
-0.020633814856410027,
-0.002554836915805936,
0.009292533621191978,
0.01245711650699377,
-0.05034065246582031,
-0.017658252269029617,
-0.010341296903789043,
0.022219154983758926,
-0.05804784595966339,
-0.01991431415081024,
0.02196306176483631,
-0.027682481333613396,
-0.018950914964079857,
-0.06063317134976387,
0.06219412013888359,
0.004445050377398729,
-0.028877584263682365,
0.0010594341438263655,
-0.02491423301398754,
0.029072701930999756,
0.07155982404947281,
0.02367035113275051,
0.01245711650699377,
-0.030462924391031265,
0.018755795434117317,
0.05638933554291725,
0.0010525744874030352,
-0.024487409740686417,
0.017816785722970963,
0.013938799500465393,
-0.008024261333048344,
0.07638901472091675,
0.017963126301765442,
-0.04370661452412605,
0.036609165370464325,
-0.038121338933706284,
-0.023853274062275887,
-0.042365171015262604,
-0.013255883939564228,
-0.04441392049193382,
0.008420595899224281,
-0.04838946461677551,
0.05507228523492813,
0.027999548241496086,
-0.07102324813604355,
0.017889956012368202,
0.019999677315354347,
0.07160860300064087,
-0.037414032965898514,
-0.026438599452376366,
-0.05916978046298027,
0.018597261980175972,
-0.001387172844260931,
0.02467033453285694,
-0.018109465017914772,
-0.05043821409344673,
0.026560548692941666,
-0.033414095640182495,
-0.026487378403544426,
-0.041365187615156174,
0.0033475069794803858,
0.007810849696397781,
-0.019438711926341057,
-0.005856613162904978,
0.0008948026807047427,
-0.032926298677921295,
-0.05965757742524147,
-0.01087177637964487,
-0.0016402174951508641,
-0.02347523160278797,
0.012938816100358963,
-0.05726737156510353,
0.06121852621436119,
0.022060619667172432,
-0.011762005276978016,
-0.0003864266909658909,
-0.07541342079639435,
0.028097108006477356,
0.06380385160446167,
-0.011396157555282116,
-0.08429132401943207,
-0.005076137837022543,
0.007487684488296509,
-0.010487635619938374,
-0.04690168425440788,
0.06068195030093193,
0.019328957423567772,
-0.025609344244003296,
0.04941383749246597,
-0.06536480039358139,
0.030121466144919395,
0.009743745438754559,
-0.011231526732444763,
-0.0947301834821701,
-0.05692591145634651,
-0.05809662491083145,
-0.013621731661260128,
0.016463149338960648,
0.008091333322227001,
0.004691997542977333,
-0.02445082552731037,
0.018133854493498802,
-0.0116278612986207,
0.033365316689014435,
-0.019207008183002472,
-0.039292048662900925,
0.025658123195171356,
-0.01212785392999649,
0.02364596165716648,
-0.05243818089365959,
0.0004950377624481916,
0.026145920157432556,
0.007323052734136581,
0.05224306136369705,
0.009694965556263924,
-0.004786508157849312,
-0.026584938168525696,
0.035682354122400284,
-0.0001337630965281278,
-0.042413949966430664,
-0.007396222557872534,
0.029877567663788795,
-0.026999564841389656,
-0.014060749672353268,
-0.015755843371152878,
-0.025682512670755386,
0.0034206765703856945,
0.010060813277959824,
0.009627893567085266,
-0.026902005076408386,
0.012182730250060558,
0.04719436168670654,
0.007231590803712606,
-0.014438792131841183,
0.029609279707074165,
-0.015402191318571568,
-0.05531618371605873,
-0.037560369819402695,
0.030926331877708435,
0.04280418902635574,
0.026219090446829796,
0.031731195747852325,
0.009701062925159931,
-0.026975175365805626,
0.025926411151885986,
-0.011085187084972858,
0.019280176609754562,
0.028462955728173256,
-0.002887148642912507,
0.0014123248402029276,
-0.033462874591350555,
-0.023170359432697296,
0.015304631553590298,
0.014536350965499878,
-0.029536109417676926,
-0.027365412563085556,
-0.033804334700107574,
0.040731050074100494,
0.025950802490115166,
0.05658445507287979,
-0.034487251192331314,
0.015292436815798283,
0.024828867986798286,
0.037365250289440155,
-0.034633588045835495,
0.005445034243166447,
-0.009548626840114594,
0.0030273902229964733,
-0.07395002990961075,
0.02201184071600437,
0.005195038393139839,
-0.010390076786279678,
0.022585002705454826,
-0.009792525321245193,
-0.02088990807533264,
-0.004435904324054718,
0.013658316805958748,
0.032145824283361435,
-0.017938734963536263,
-0.036877453327178955,
-0.010707144625484943,
-0.020853321999311447,
-0.017280209809541702,
0.019572855904698372,
-0.002605140907689929,
-0.027828820049762726,
0.04297491908073425,
-0.020072847604751587,
0.0023978273384273052,
0.023999612778425217,
-0.005655396729707718,
0.016463149338960648,
-0.007871824316680431,
0.034194570034742355,
-0.0019908216781914234,
-0.037828657776117325,
0.0238654688000679,
0.0003763277782127261,
0.035877469927072525,
-0.019207008183002472,
0.0028444663621485233,
0.004149323329329491,
0.025633733719587326,
-0.0005579178687185049,
-0.04665778577327728,
-0.0007092111627571285,
0.0037225009873509407,
0.024365460500121117,
-0.008329134434461594,
-0.017280209809541702,
-0.031462907791137695,
-0.013243689201772213,
-0.026048360392451286,
-0.0011272684205323458,
-0.043096866458654404,
0.007262078113853931,
-0.007286468055099249,
0.018182633444666862,
-0.039633508771657944,
-0.026584938168525696,
0.05443814769387245,
-0.030267804861068726,
0.05248695984482765,
-0.019658220931887627,
-0.04107251018285751,
0.021426483988761902,
0.013914410024881363,
-0.008194990456104279,
-0.038974981755018234,
-0.013329053297638893,
0.0839986503124237,
-0.00534442625939846,
-0.015658283606171608,
0.030682433396577835,
0.006039537023752928,
-0.0010243738070130348,
-0.0007271224167197943,
0.009853499941527843,
-0.05209672078490257,
0.005066991783678532,
-0.04177981615066528,
-0.0016097301850095391,
-0.025950802490115166,
-0.031975094228982925,
0.016511930152773857,
-0.016707047820091248,
-0.04619437828660011,
-0.024633750319480896,
-0.02213378995656967,
0.019999677315354347,
-0.04692607372999191,
0.039511557668447495,
-0.022438663989305496,
0.016865581274032593,
0.012438824400305748,
0.011463230475783348,
0.017450938001275063,
-0.009323020465672016,
-0.05429180711507797,
0.018633846193552017,
-0.024145953357219696,
-0.010633975267410278,
0.032975077629089355,
-0.013780266046524048,
0.020682593807578087,
0.015609504655003548,
-0.004170664586126804,
-0.02379230037331581,
0.027462972328066826,
-0.009408385492861271,
0.030389754101634026,
0.003201168030500412,
-0.004356637131422758,
0.020853321999311447,
0.029828788712620735,
-0.008475473150610924,
-0.005850515328347683,
0.010451051406562328,
-0.027121514081954956,
0.005176745820790529,
0.016938751563429832,
-0.035901859402656555,
0.05497472360730171,
-0.043828561902046204,
0.018450923264026642,
0.07399880886077881,
0.07360856980085373,
-0.0124815059825778,
0.035194553434848785,
-0.009554724209010601,
-0.025926411151885986,
-0.016670463606715202,
-0.012097366154193878,
0.037755489349365234,
0.017450938001275063,
-0.019865533336997032,
0.02462155558168888,
-0.0038231092039495707,
0.027023954316973686,
0.005618812050670385,
-0.025487395003437996,
0.016719242557883263,
-0.012268095277249813,
0.0017118626274168491,
-0.05965757742524147,
0.012560773640871048,
0.0474870391190052,
0.02064600959420204,
-0.0012918999418616295,
-0.09009610861539841,
0.013536367565393448,
-0.014487572014331818,
0.007609633728861809,
-0.025999581441283226,
-0.030121466144919395,
-0.031804364174604416,
0.018438726663589478,
-0.009280337952077389,
0.07507196068763733,
0.05277963727712631,
0.04970651492476463,
0.006676721852272749,
-0.034438468515872955,
-0.04885287210345268,
-0.038145728409290314,
0.014194893650710583,
0.009432774968445301,
0.0022575855255126953,
-0.002359718084335327,
0.017328988760709763,
-0.027658091858029366,
-0.017109479755163193,
0.014804639853537083,
0.02225573919713497,
-0.007402319926768541,
-0.0039999354630708694,
-0.037999387830495834,
-0.05019431561231613,
0.05590153858065605,
-0.004881018772721291,
0.02367035113275051,
0.045828528702259064,
-0.02284109592437744,
-0.003987740725278854,
-0.008957172743976116,
-0.002829222707077861,
-0.0006611936260014772,
-0.02310938388109207,
-0.004536512307822704,
-0.016670463606715202,
-0.035365283489227295,
-0.018548481166362762,
0.07570609450340271,
0.032194603234529495,
-0.021780136972665787,
0.016060717403888702,
0.05014553293585777,
-0.031048281118273735,
0.029609279707074165,
-0.04204810410737991,
0.032609231770038605,
-0.013109545223414898,
-0.020353330299258232,
0.013755875639617443,
-0.021609408780932426,
0.019816754385828972,
0.025072766467928886,
0.008780346252024174,
0.020963076502084732,
-0.039657898247241974,
0.017426548525691032,
0.004466391634196043,
-0.027219073846936226,
0.033438485115766525,
-0.0046249255537986755,
-0.06399896740913391,
-0.0010388551745563745,
0.06151120364665985,
-0.030511703342199326,
-0.012146146036684513,
0.008170600049197674,
0.06873060017824173,
-0.034511640667915344,
-0.0031828756909817457,
-0.031389739364385605,
-0.02406058833003044,
-0.010682755149900913,
0.031097060069441795,
-0.015963157638907433,
0.006890133023262024,
-0.06058438867330551,
0.027682481333613396,
-0.0055090575478971004,
-0.025584954768419266,
0.009109609760344028,
0.0012141573242843151,
0.04965773597359657,
0.012560773640871048,
-0.015377800911664963,
0.035340894013643265,
0.0006364226574078202,
0.035682354122400284,
-0.016804607585072517,
0.014243673533201218,
0.0036218930035829544,
0.027097124606370926,
0.039243269711732864,
0.0008658397127874196,
0.035560403019189835,
-0.031487297266721725,
0.040413983166217804,
-0.016292421147227287,
0.005582227371633053,
0.017170455306768417,
-0.01224980317056179,
0.005963318515568972,
-0.024170342832803726,
-0.003256045049056411,
-0.004124933388084173,
-0.041121289134025574,
0.021804526448249817,
-0.027511751279234886,
0.025633733719587326,
0.032292161136865616,
0.023609375581145287,
0.008079138584434986,
0.04902360215783119,
-0.016768023371696472,
0.026511767879128456,
0.013768071308732033,
0.038072556257247925,
-0.038316454738378525,
0.0052651590667665005,
-0.004152372013777494,
-0.014036359265446663,
0.0022972191218286753,
-0.003108181757852435,
-0.05292597785592079,
-0.04975529760122299,
-0.018243608996272087,
0.007920604199171066,
0.015499750152230263,
-0.021389899775385857,
0.0007408417295664549,
-0.013914410024881363,
-0.019499685615301132,
-0.034536030143499374,
-0.0037926218938082457,
-0.04965773597359657,
-0.041609086096286774,
-0.07126714289188385,
0.0005548691260628402,
-0.008457181043922901,
0.009914474561810493,
0.021731358021497726,
-0.02354840189218521,
-0.028267838060855865,
-0.020597228780388832,
0.014853419736027718,
-0.017768006771802902,
-0.030950721353292465,
0.016450954601168633,
-0.024389851838350296,
0.007932798936963081,
-0.0016508880071341991,
0.014097333885729313,
0.041926153004169464,
0.009883986786007881,
-0.008670591749250889,
0.0032499476801604033,
0.0006078408332541585,
0.021072831004858017,
-0.032438501715660095,
0.02281670644879341,
-0.006493797991424799,
0.014048554003238678,
-0.02232890948653221,
-0.011072992347180843,
-0.020499669015407562,
0.005179794505238533,
-0.029560498893260956,
0.016841191798448563,
0.007335247937589884,
0.014377817511558533,
-0.030877551063895226,
-0.04990163445472717,
0.00621636351570487,
0.011487619951367378,
0.008054748177528381,
-0.02359718084335327,
0.021877696737647057,
0.004664558917284012,
0.030194636434316635,
0.008152307942509651,
-0.025755682960152626,
0.032901909202337265,
-0.005780394654721022,
-0.012975401245057583,
0.020609423518180847,
0.004036520142108202,
-0.011554691940546036,
-0.028219057247042656,
-0.025341056287288666,
0.0010914457961916924,
0.04965773597359657,
-0.025658123195171356,
0.002486240351572633,
-0.041828595101833344,
-0.013572951778769493,
0.013121739961206913,
0.02281670644879341,
0.007073056884109974,
-0.018328974023461342,
0.041828595101833344,
0.0006009811768308282,
-0.001336106564849615,
0.028560515493154526,
-0.011121772229671478,
0.025341056287288666,
-0.040121305733919144,
0.029804397374391556,
0.04231639206409454,
-0.015987547114491463,
-0.021914280951023102,
-0.008085235953330994,
-0.023121578618884087,
0.05107234790921211,
0.035828690975904465,
-0.029901957139372826,
-0.015463165938854218,
0.027560532093048096,
0.02376791089773178,
0.037511590868234634,
-0.034804318100214005,
0.009786427952349186,
0.028097108006477356,
-0.0013620207319036126,
-0.020609423518180847,
-0.019133837893605232,
0.027072735130786896,
-0.021316729485988617,
-0.005887100473046303,
0.016889972612261772,
0.0067133065313100815,
-0.011676641181111336,
0.013694901019334793,
-0.05151136592030525,
0.0038231092039495707,
0.016792412847280502,
0.028048329055309296,
-0.0003713736077770591,
0.004975529853254557,
-0.0016874728025868535,
-0.013926604762673378,
0.027731260284781456,
0.005316987633705139,
-0.015341216698288918,
0.030926331877708435,
0.020389916375279427,
0.0018155195284634829,
-0.00008803211676422507,
-0.015487555414438248,
0.024780089035630226,
-0.023438647389411926,
-0.028097108006477356,
0.017938734963536263,
-0.04977968707680702,
0.027267852798104286,
0.005624909419566393,
-0.010920556262135506,
-0.011487619951367378,
-0.020560644567012787,
-0.026731276884675026,
0.003710306016728282,
-0.022950850427150726,
0.009396189823746681,
-0.004871872719377279,
0.0034298228565603495,
0.018121659755706787,
0.022121595218777657,
0.06931595504283905,
-0.031072670593857765,
0.011005920358002186,
-0.037511590868234634,
-0.007701095659285784,
0.007365735247731209,
0.015877792611718178,
0.009481554850935936,
0.012670528143644333,
0.002484716009348631,
0.013121739961206913,
0.07990115135908127,
-0.014072944410145283,
-0.007975481450557709,
0.0012133951531723142,
0.004451147746294737,
0.018926523625850677,
0.01205468364059925,
-0.018353363499045372,
-0.007627925835549831,
0.009688868187367916,
-0.0051554045639932156,
-0.009042537771165371,
-0.04463342949748039,
-0.06024293228983879,
0.003789573209360242,
-0.019414322450757027,
0.0010906836250796914,
-0.003039585193619132,
0.008768151514232159,
-0.0013307712506502867,
-0.0029039166402071714,
-0.015475360676646233,
-0.009914474561810493,
0.009676673449575901,
0.004618828184902668,
0.0069998870603740215,
-0.015133902430534363,
-0.0013254359364509583,
-0.029536109417676926,
-0.019353346899151802,
0.020792348310351372,
0.028316617012023926,
0.03980423882603645,
0.008316939696669579,
0.011365670710802078,
-0.013109545223414898,
-0.023853274062275887,
-0.021316729485988617,
0.021146001294255257,
0.007682803086936474,
0.014963173307478428,
-0.00006812009087298065,
-0.05463326722383499,
-0.027438582852482796,
0.003719452302902937,
0.012743697501718998,
0.020182602107524872,
0.041145678609609604,
0.004487732425332069,
0.031487297266721725,
-0.019780170172452927,
0.029316600412130356,
-0.031950704753398895,
-0.014390012249350548,
0.05380401015281677,
0.033340927213430405,
-0.05263330042362213,
0.032365333288908005,
-0.04321881756186485,
0.0010411418043076992,
0.01212785392999649,
-0.005240769125521183,
-0.007310857996344566,
-0.004469440318644047,
-0.021426483988761902,
0.030779991298913956,
-0.0004557853389997035,
0.00031554370070807636,
0.004506024997681379,
0.004054812714457512,
0.06434042751789093,
-0.003007573541253805,
-0.05819418653845787,
-0.007024277001619339,
-0.032609231770038605,
0.014438792131841183,
0.04375539347529411,
0.012792477384209633,
0.005887100473046303,
-0.004588340874761343,
0.008719371631741524,
0.008743762038648129,
-0.001885640318505466,
0.004426757805049419,
0.01205468364059925,
-0.032950688153505325,
-0.0000992743152892217,
-0.00032202224247157574,
-0.06897450238466263,
-0.031023891642689705,
-0.006993789691478014,
0.009127901867032051,
-0.0029145872686058283,
-0.012042488902807236,
-0.009188876487314701,
0.006173681002110243,
-0.006341361440718174,
0.011987611651420593,
-0.013329053297638893,
0.0228898748755455,
-0.0008338280604220927,
-0.030828772112727165,
0.0002109341003233567,
-0.014987563714385033,
0.013304663822054863,
0.017707031220197678,
-0.014853419736027718,
0.0055090575478971004,
-0.013682706281542778,
0.011707128956913948,
-0.017475327476859093,
-0.018487507477402687,
0.006688916590064764,
0.011024212464690208,
-0.012999790720641613,
0.013938799500465393,
-0.004801752045750618,
0.004231639206409454,
0.0016204006969928741,
-0.021536238491535187,
-0.013243689201772213,
0.036170151084661484,
-0.018926523625850677,
0.0243532657623291,
-0.009048635140061378,
0.014707080088555813,
0.014646105468273163,
-0.09843743592500687,
-0.026365429162979126,
-0.021414289250969887,
-0.018987499177455902,
-0.012469311244785786,
0.014109528623521328,
-0.02149965427815914,
-0.02110941708087921,
-0.008682787418365479,
-0.011981514282524586,
0.028145888820290565,
-0.04280418902635574,
-0.015487555414438248,
0.008103528060019016,
0.0018764941487461329,
-0.0036920136772096157,
0.0013856483856216073,
-0.04375539347529411,
0.019658220931887627,
0.02147526480257511,
0.012816866859793663,
0.02486545406281948,
-0.015597309917211533,
0.0022042328491806984,
-0.015231462195515633,
0.0034572614822536707,
-0.0048078494146466255,
-0.025463005527853966,
-0.029194651171565056,
0.028243448585271835,
0.037023793905973434,
0.024731308221817017,
0.016182666644454002,
0.020560644567012787,
-0.018914328888058662,
-0.032536063343286514,
0.009249851107597351,
-0.013829045929014683,
0.009237656369805336,
-0.0064389207400381565,
0.01178639568388462,
0.005115771200507879,
0.013316858559846878,
0.010438856668770313,
-0.02488984353840351,
-0.003515187418088317,
-0.015426580794155598,
0.0037438422441482544,
0.031292177736759186,
-0.007463294547051191,
-0.0067133065313100815,
-0.019926508888602257,
-0.033072639256715775,
0.025438614189624786,
0.006158437579870224,
-0.0054785702377557755,
-0.007847434841096401,
0.016389980912208557,
0.018792379647493362,
-0.029389770701527596,
-0.007566951215267181,
0.040365204215049744,
0.025463005527853966,
-0.004649315495043993,
-0.015133902430534363,
-0.027292244136333466,
-0.020597228780388832,
0.026438599452376366,
-0.039438389241695404,
0.012365654110908508,
-0.027267852798104286,
0.028536126017570496,
-0.037487201392650604,
0.006640137173235416,
-0.034682366997003555,
0.0024786186404526234,
-0.003649331396445632,
-0.010713241994380951,
-0.018914328888058662,
0.023365477100014687,
-0.018731405958533287,
-0.07282809913158417,
-0.031170230358839035,
0.008798638358712196,
-0.010914457961916924,
-0.0029115385841578245,
-0.0006249899161048234,
0.005411498248577118,
0.002817027736455202,
-0.0124815059825778,
-0.024706918746232986,
-0.017585081979632378,
-0.019231397658586502,
0.005929782520979643,
-0.008804736658930779,
-0.020633814856410027,
-0.016524124890565872,
-0.02245085872709751,
-0.022487442940473557,
-0.00273318774998188,
0.013133934698998928,
-0.04948700964450836,
0.0032773863058537245,
-0.028755635023117065,
0.016219250857830048,
-0.032389722764492035,
0.030389754101634026,
-0.007731582969427109,
-0.005786492023617029,
-0.033097028732299805,
0.039462778717279434,
0.028560515493154526,
0.036096978932619095,
-0.012987595982849598,
-0.01182298082858324,
0.015646088868379593,
0.04616998881101608,
-0.027536142617464066,
0.0028627587016671896,
0.015475360676646233,
0.07048667222261429,
-0.003405432915315032,
0.030950721353292465,
-0.0034328715410083532,
0.014658300206065178,
0.018438726663589478,
0.003832255257293582,
0.04768215864896774,
-0.01081080175936222,
0.012207120656967163,
0.013255883939564228,
0.018780184909701347,
-0.025194715708494186,
-0.010725436732172966,
-0.007713290397077799,
0.017926540225744247,
0.04153591766953468,
0.007579146418720484,
-0.0006813914515078068,
-0.0021097222343087196,
-0.017036311328411102,
0.005228574387729168,
0.011597374454140663,
-0.02235329896211624,
0.017438743263483047,
-0.007438904605805874,
-0.0491943284869194,
0.040609102696180344,
-0.0034694562200456858,
0.005542593542486429,
-0.0037042086478322744,
0.004524317570030689,
0.02457277476787567,
0.046535834670066833,
-0.0024435583036392927,
0.06029171124100685,
-0.0018261901568621397,
-0.020206991583108902,
-0.037706710398197174,
-0.02257280796766281,
-0.026438599452376366,
0.04792605713009834,
-0.037584759294986725,
-0.034536030143499374,
0.015463165938854218,
-0.028097108006477356,
-0.030194636434316635,
0.012670528143644333,
0.022292323410511017,
0.0011912918416783214,
0.004993821959942579,
-0.046999242156744,
0.032243382185697556,
0.015268046408891678,
-0.006176729686558247,
-0.008079138584434986,
-0.004463342949748039,
-0.010457148775458336,
0.021560627967119217,
0.040365204215049744,
-0.031853146851062775,
-0.019694805145263672,
0.029267821460962296,
0.028389787301421165,
0.039853017777204514,
-0.034926265478134155,
-0.012365654110908508,
-0.016865581274032593,
0.034121401607990265,
-0.004039569292217493,
-0.025828853249549866,
0.004103592596948147,
0.008219379931688309,
0.05121868848800659,
0.034292131662368774,
-0.037072572857141495,
0.023755714297294617,
0.02293865568935871,
-0.017207039520144463,
-0.030462924391031265,
-0.026975175365805626,
0.06243801862001419,
0.04685290530323982,
-0.014707080088555813,
-0.005054796580225229,
-0.004344442393630743,
0.0064084334298968315,
-0.040096916258335114,
-0.018231414258480072,
0.04546268284320831,
0.008786443620920181,
0.022072814404964447,
-0.030219025909900665,
-0.007512073963880539,
0.031072670593857765,
-0.002714895410463214,
-0.0015251279110088944,
0.014694885350763798,
-0.028975144028663635,
-0.031779974699020386,
-0.040584713220596313,
-0.028828803449869156,
0.0037956705782562494,
-0.031658027321100235,
0.021426483988761902,
-0.007195006124675274,
0.0068779378198087215,
0.004100543912500143,
0.005310890264809132,
0.015816818922758102,
-0.017085090279579163,
0.05263330042362213,
-0.0033322633244097233,
-0.0064267260022461414,
-0.016658268868923187,
-0.010091301053762436,
-0.011652251705527306,
-0.0016234494978561997,
-0.014536350965499878,
-0.016389980912208557,
0.036950625479221344,
-0.006737696472555399,
-0.020414305850863457,
-0.016024131327867508,
-0.025511784479022026,
-0.002393254078924656,
0.039974965155124664,
-0.014890003949403763,
-0.03956034034490585,
-0.012377849780023098,
-0.019487490877509117,
-0.0048566292971372604,
0.027219073846936226,
0.05219428241252899,
0.026828836649656296,
0.005585276056081057,
0.000215126114198938,
0.004301759880036116,
0.027828820049762726,
-0.00002667640001163818,
-0.035487234592437744,
-0.012560773640871048,
-0.014243673533201218,
-0.019292373210191727,
0.029560498893260956,
-0.019780170172452927,
0.0066645266488194466,
-0.015707064419984818,
0.0006333739729598165,
-0.011310793459415436,
0.023609375581145287,
0.0059816110879182816,
-0.026902005076408386,
0.010786411352455616,
0.026219090446829796,
-0.031292177736759186,
0.011109577491879463,
-0.0052956463769078255,
-0.008524253033101559,
0.001842958154156804,
-0.025316664949059486,
0.026414208114147186,
-0.036779895424842834,
0.021706966683268547,
0.033218976110219955,
-0.008146210573613644,
-0.04590170085430145,
-0.015975352376699448,
0.027780041098594666,
-0.016963141039013863,
-0.007634023204445839,
0.005481618922203779,
0.012975401245057583,
-0.0028414176777005196,
0.0020030164159834385,
-0.026755666360259056,
-0.006079170387238264,
-0.030145855620503426,
0.034560419619083405,
-0.014365622773766518,
0.014194893650710583,
0.012670528143644333,
-0.004344442393630743,
-0.039926186203956604,
0.001448909635655582,
0.007201103493571281,
-0.004920652601867914,
-0.029536109417676926,
0.0032804349903017282,
-0.022243544459342957,
-0.04156030714511871,
-0.0015373227652162313,
-0.019987482577562332,
-0.027706870809197426,
0.009396189823746681,
0.009573016315698624,
-0.021206974983215332,
0.017194844782352448,
-0.023853274062275887,
0.012072976678609848,
-0.013511977158486843,
0.014377817511558533,
0.026511767879128456,
-0.0014428121503442526,
-0.013902215287089348,
0.018816770985722542,
0.0009092841646634042,
-0.005335279740393162,
-0.016011936590075493,
-0.015085122548043728,
0.023609375581145287,
-0.0008749858825467527,
-0.0066645266488194466,
0.011719323694705963,
0.025877632200717926,
0.026170309633016586,
-0.0239874180406332,
0.004466391634196043,
0.015572920441627502,
-0.024975206702947617,
0.004661510232836008,
0.0010655316291376948,
0.026828836649656296,
0.000790383608546108,
0.016365589573979378,
0.001955761108547449,
0.028706854209303856,
-0.011597374454140663,
0.007774265017360449,
-0.010469343513250351,
0.07092569023370743,
0.0014405256370082498,
-0.027145903557538986,
0.036023810505867004,
0.008359621278941631,
0.000861266627907753,
0.006432823371142149,
0.037609148770570755,
-0.00047788865049369633,
0.008573032915592194,
-0.002957269549369812,
0.006054780445992947,
0.024389851838350296,
-0.018341168761253357,
0.0067864758893847466,
0.013170519843697548,
-0.030926331877708435,
0.017268015071749687,
-0.008902295492589474,
0.013304663822054863,
-0.006384043488651514,
-0.0027194684371352196,
0.00027343310648575425,
0.015707064419984818,
0.0025594099424779415,
0.018024099990725517,
0.039731066673994064,
0.0012614126317203045,
-0.004057861398905516,
0.02162160351872444,
0.009152291342616081,
-0.009920571930706501,
0.01229858212172985,
-0.0068047684617340565,
-0.007798654958605766,
-0.025243496522307396,
-0.029536109417676926,
-0.022219154983758926,
0.016963141039013863,
-0.024706918746232986,
0.033267758786678314,
-0.0015053111128509045,
0.019060669466853142,
0.026511767879128456,
0.0031859243754297495,
0.0025182522367686033,
0.008536447770893574,
0.008249866776168346,
-0.005816979333758354,
0.004798703361302614,
-0.009066927246749401,
-0.026926396414637566,
0.013560757040977478,
0.017133871093392372,
0.018646040931344032,
0.013914410024881363,
-0.004789556842297316,
0.020548449829220772,
0.032487280666828156,
0.008908392861485481,
-0.02437765710055828,
0.013499782420694828,
-0.035657960921525955,
0.011938831768929958,
-0.02123136632144451,
-0.025706904008984566,
-0.0014565314631909132,
-0.05082844942808151,
-0.039365220814943314,
0.0026219089049845934,
0.017731422558426857,
0.0006573827122338116,
-0.0008948026807047427,
0.018365558236837387,
-0.004359685815870762,
-0.020353330299258232,
0.008402303792536259,
0.006390140857547522,
0.002573129255324602,
0.018767990171909332,
0.018487507477402687,
-0.013390027917921543,
0.019719194620847702,
0.007402319926768541,
-0.04226761311292648,
0.029219042509794235,
-0.009268143214285374,
0.024950817227363586,
-0.04204810410737991,
-0.005603568162769079,
0.007951091043651104,
0.015707064419984818,
0.023072799667716026,
0.025243496522307396,
0.006603552028536797,
-0.00017549260519444942,
0.01093275099992752,
0.006176729686558247,
0.038511574268341064,
0.025145936757326126,
0.027487361803650856,
-0.006920620333403349,
-0.034779928624629974,
0.0010769643122330308,
-0.025609344244003296,
-0.004853580612689257,
-0.016963141039013863,
-0.011158357374370098,
0.029901957139372826,
0.017889956012368202,
-0.027901990339159966,
-0.001166139729321003,
-0.015682674944400787,
0.022804511711001396,
-0.0037529882974922657,
-0.015999741852283478,
0.0014984514564275742,
0.019048472866415977,
0.00516150239855051,
0.0009733075276017189,
0.019267981871962547,
0.028170278295874596,
0.013633926399052143,
0.019999677315354347,
0.022292323410511017,
-0.040023744106292725,
0.0119937090203166,
0.00571027398109436,
0.024633750319480896,
-0.013219299726188183,
-0.031584858894348145,
0.018938720226287842,
-0.0035609183833003044,
-0.019633829593658447,
0.027243463322520256,
0.022402077913284302,
-0.010652267374098301,
-0.0233776718378067,
0.036267708986997604,
-0.0035304310731589794,
-0.010719339363276958,
0.008243769407272339,
0.01242053136229515,
-0.007054764311760664,
-0.014109528623521328,
-0.023926444351673126,
-0.019316762685775757,
-0.010170567780733109,
-0.015194877050817013,
0.012780281715095043,
-0.035950642079114914,
-0.007005984894931316,
-0.011694933287799358,
-0.004756020847707987,
-0.014072944410145283,
-0.022024035453796387,
-0.02354840189218521,
-0.05921855941414833,
-0.007865726947784424,
-0.013719291426241398,
-0.041389577090740204,
-0.035804301500320435,
-0.008792540989816189,
0.020475279539823532,
0.035828690975904465,
-0.02235329896211624,
0.004951139912009239,
0.05038943141698837,
0.009194973856210709,
-0.007993773557245731,
0.018743600696325302,
0.013902215287089348,
0.0018109465017914772,
0.001812470844015479,
-0.05985269322991371,
0.021950865164399147,
-0.0232557225972414,
0.037999387830495834,
-0.027560532093048096,
0.024975206702947617,
0.004774313420057297,
-0.011066894978284836,
0.022804511711001396,
-0.027950769290328026,
-0.012585163116455078,
0.020975271239876747,
0.006548675242811441,
0.011024212464690208,
-0.0020228333305567503,
-0.008877906017005444,
-0.00503955315798521,
0.012719307094812393,
0.014792445115745068,
-0.0052956463769078255,
0.002027406357228756,
0.027145903557538986,
0.04941383749246597,
-0.01243272703140974,
-0.013536367565393448,
0.014743665233254433,
0.025267885997891426,
-0.010780313983559608,
-0.013121739961206913,
0.033389706164598465,
0.001998443389311433,
-0.045096833258867264,
0.0005804022657684982,
0.014255868270993233,
-0.029780007898807526,
-0.0018810672918334603,
0.015938768163323402,
-0.002920684637501836,
0.002938976977020502,
0.031609248369932175,
0.004850531462579966,
-0.013109545223414898,
0.0004325387708377093,
0.007944993674755096,
-0.02274353615939617,
0.022438663989305496,
-0.026170309633016586,
-0.034633588045835495,
-0.004938944708555937,
-0.009396189823746681,
-0.023341087624430656,
-0.0048871166072785854,
-0.000547247298527509,
-0.008079138584434986,
-0.018926523625850677,
0.015499750152230263,
-0.032316554337739944,
-0.027048345655202866,
-0.037414032965898514,
0.019426517188549042,
-0.007359637413173914,
-0.006859645713120699,
-0.008292549289762974,
-0.021219169721007347,
-0.009505944326519966,
-0.012597357854247093,
-0.032755568623542786,
-0.002035028301179409,
-0.005152355879545212,
-0.029023922979831696,
0.016670463606715202,
0.035487234592437744,
-0.010633975267410278,
-0.008146210573613644,
-0.033609215170145035,
0.0010159896919503808,
0.0034328715410083532,
0.003384091891348362,
-0.02391424961388111,
-0.019158227369189262,
0.0035792107228189707,
-0.025780072435736656,
-0.015255851671099663,
-0.05799906700849533,
-0.008414498530328274,
0.016487538814544678,
-0.032609231770038605,
-0.014060749672353268,
0.0028734293300658464,
0.010213250294327736,
-0.019743584096431732,
0.018207024782896042,
-0.04453586786985397,
-0.015011953189969063,
0.017694836482405663,
-0.003966399468481541,
-0.005740761291235685,
0.02357279136776924,
-0.02086551859974861,
0.0045029763132333755,
-0.02003626339137554,
0.041877374053001404,
-0.020133821293711662,
0.003007573541253805,
0.045048054307699203,
-0.014463181607425213,
-0.019646024331450462,
0.009292533621191978,
-0.020097237080335617,
-0.034267742186784744,
-0.005597470793873072,
-0.0030060491990298033,
0.007609633728861809,
0.011201038956642151,
-0.017377769574522972,
-0.005545642226934433,
-0.012511993758380413,
0.011042505502700806,
-0.006512090098112822,
-0.000951966387219727,
-0.021950865164399147,
0.04226761311292648,
-0.017133871093392372,
-0.044340748339891434,
-0.022511832416057587,
0.004816995467990637,
-0.04151152819395065,
0.034877486526966095,
0.030755601823329926,
-0.004954188596457243,
0.029999516904354095,
-0.017231428995728493,
-0.022304518148303032,
0.029194651171565056,
-0.028145888820290565,
-0.013585147447884083,
0.041828595101833344,
-0.005411498248577118,
0.013633926399052143,
0.031023891642689705,
0.017414353787899017,
-0.008725469000637531,
0.018402142450213432,
0.019621634855866432,
-0.020999662578105927,
0.009505944326519966,
-0.035950642079114914,
-0.007554756477475166,
-0.022365493699908257,
-0.016377784311771393,
0.1049739196896553,
0.02440204657614231,
-0.012707112357020378,
0.028267838060855865,
-0.008859613910317421,
-0.027487361803650856,
0.007627925835549831,
-0.0026813591830432415,
0.013280274346470833,
0.0011714750435203314,
0.0016493636649101973,
0.011377865448594093,
0.014133919030427933,
0.003289581276476383,
0.017194844782352448,
-0.005847466643899679,
-0.016816802322864532,
0.031584858894348145,
0.005990757141262293,
-0.004448099061846733,
0.0005582989542745054,
0.022463053464889526,
-0.0028612343594431877,
0.016450954601168633,
-0.0066828192211687565,
-0.019365541636943817,
-0.015865597873926163,
0.011426645331084728,
0.020170407369732857,
-0.022828901186585426,
0.012719307094812393,
-0.004512122366577387,
0.009573016315698624,
-0.014438792131841183,
0.005725517403334379,
-0.008573032915592194,
0.005195038393139839,
-0.017914345487952232,
0.008780346252024174,
0.014780249446630478,
-0.008304744027554989,
-0.009573016315698624,
0.021170390769839287,
-0.007249883376061916,
0.028975144028663635,
-0.018365558236837387,
-0.023438647389411926,
-0.004545658361166716,
0.012755892239511013,
-0.021365510299801826,
0.004371881019324064,
0.009731550700962543,
0.018255803734064102,
-0.007951091043651104,
-0.0034786025062203407,
-0.007585243787616491,
0.009804720059037209,
0.002612762851640582,
-0.009249851107597351,
-0.019585050642490387,
-0.026194700971245766,
0.017853371798992157,
0.030316585674881935,
0.037389643490314484,
0.024292292073369026
] | 2025-01-07 | 49 | 39763668 | [
"%",
"67.9%-84.7%",
"BCMA",
"BCMA CAR-T treatment",
"MRD negativity rate",
"GPRC5D",
"BCMA CAR-T",
"GPRC5D CAR-T",
"GPRC5D CAR T-cell therapy",
"RRMM patients",
"relapse rate",
"BCMA CAR-T and GPRC5D CAR-T",
"eligible clinical trials",
"chimeric antigen receptor",
"overall response rate",
"CAR)-T cells",
"BCMA CAR-T-cell therapy",
"95% CI",
"Clinical studies",
"the BCMA CAR-T group",
"CI",
"the GPRC5D CAR-T cohort",
"patients",
"undergone relapse",
"RRMM",
"efficacy",
"acceptable safety",
"release syndrome",
"immune effector cell-associated neurotoxicity syndrome",
"0.0%-6.5%"
] | [
"B-cell maturation antigen",
"G protein-coupled receptor",
"car-T",
"class C group 5 member D",
"relapsed or refractory multiple myeloma"
] | 0 | 10.3389/fimmu.2024.1466443
10.1016/S1470-2045(14)70442-5
10.1038/s41408-020-00359-2
10.3390/jpm11050334
10.1016/S0140-6736(14)60493-1
10.1200/JCO.2013.48.7934
10.1016/S0140-6736(16)31594-X
10.1056/NEJMoa1402551
10.1038/leu.2017.138
10.1182/blood-2015-07-635383
10.3324/haematol.2020.276402
10.1038/s41375-020-0930-x
10.1200/JCO.2018.77.8084
10.1111/ejh.v112.2
10.1056/NEJMc2030164
10.1056/NEJMoa1709919
10.1056/NEJMoa1707447
10.1056/NEJMoa1709866
10.1126/scitranslmed.aau7746
10.1182/blood.2019003342
10.1056/NEJMoa2209900
10.1016/S1470-2045(16)30206-6
10.1046/j.1445-2197.2003.02748.x
10.1016/j.jclinepi.2010.07.017
10.1007/s12185-023-03538-6
10.3324/haematol.2022.281628
10.1038/s41591-022-02182-7
10.1136/jitc-2022-005145
10.1002/ajh.26583
10.1056/NEJMoa2024850
10.1056/NEJMoa1817226
10.1182/blood-2020-140410
10.1182/blood-2020-138734
10.1182/blood-2020-139802
10.1182/blood-2019-127608
10.1172/JCI126397
10.1182/blood-2018-99-112786
10.1200/JCO.22.01824
10.1016/S2352-3026(22)00372-6
10.1182/blood-2023-181857
10.1182/blood-2023-181857
10.3322/caac.21771
10.1182/hematology.2022000396
10.1080/07853890.2021.1970218
10.1111/ejh.v104.4
10.1084/jem.20031330
10.1038/s41591-021-01245-5
10.1038/s41467-021-21177-5
10.3324/haematol.2020.266841
10.1007/s00262-023-03559-4
10.1111/j.1365-2362.2012.02679.x
10.1111/j.1365-2362.2012.02679.x
10.1111/j.1365-2141.2012.09241.x
10.1038/ncomms8333
10.1038/s41375-019-0660-0
10.1016/j.ccell.2017.02.001 | [
"Yang",
"Wang",
"Yuan",
"Yang",
"Chen",
"Cheng",
"Liu",
"Tang",
"Xu",
"Wang",
"He",
"Liu",
"Li"
] | [
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.\nAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.",
"Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.",
"Fourth Medical Center, People's Liberation Army General Hospital, Beijing, China.",
"Department of Hematology, The 920th Hospital of Joint Logistics Support Force, Kunming, Yunnan, China.",
"Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.",
"Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China."
] | [
"39763668",
"25439696",
"32989217",
"33922567",
"25540889",
"24419113",
"28017406",
"25184863",
"37658559",
"28620163",
"26679866",
"33792221",
"32572190",
"29812997",
"37545132",
"33596362",
"29385376",
"29226797",
"29385370",
"30918115",
"32040549",
"36170501",
"27511158",
"12956787",
"21247734",
"36690910",
"36200421",
"36690811",
"36100310",
"35488407",
"33626253",
"31042825",
"30896447",
"36881785",
"36725117",
"36627265",
"36485132",
"34459681",
"31883150",
"14707116",
"33619368",
"33558511",
"36263838",
"37924369",
"22591013",
"22804669",
"26065893",
"31776467",
"28262555"
] | [] | 5.109542 | 5.783523 |
39763064 | 69 | Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR. | Paediatric sarcomas, including rhabdomyosarcoma, Ewing sarcoma and osteosarcoma, represent a group of malignancies that significantly contribute to cancer-related morbidity and mortality in children and young adults. These cancers share common challenges, including high rates of metastasis, recurrence or treatment resistance, leading to a 5-year survival rate of approximately 20% for patients with advanced disease stages. Despite the critical need, therapeutic advancements have been limited over the past three decades. The advent of chimeric antigen receptor (CAR)-based immunotherapies offers a promising avenue for novel treatments. However, CAR-T cells have faced significant challenges and limited success in treating solid tumours due to issues such as poor tumour infiltration, immunosuppressive tumour microenvironments and off-target effects. In contrast, the adaptation of CAR technology for natural killer (NK) cells has demonstrated potential in both haematological and solid tumours, suggesting a new therapeutic strategy for paediatric sarcomas.
This study developed and validated a novel CAR-NK cell therapy targeting the ephrin type-A receptor-2 (EphA2) antigen, which is highly expressed in various paediatric sarcomas.
CAR expression was successfully detected on the surface of NK cells post-electroporation, indicating successful transfection. Significantly, EphA2-specific CAR-NK cells demonstrated enhanced cytotoxic activity against several paediatric sarcoma cell lines in vitro, including those of rhabdomyosarcoma, Ewing sarcoma and osteosarcoma, compared to unmodified NK cells. Transient messenger RNA (mRNA) transfection of NK cells is a safe approach in genetic engineering, with further chemical modifications to mRNA enhancing stability of temporal EphA2-CAR expression in NK cells, thereby promoting prolonged protein expression. Additionally, in vivo EphA2-CAR-NK cells showed promising anti-cancer activity in rhabdomyosarcoma and osteosarcoma mouse models.
The study provides a foundational basis for the clinical evaluation of EphA2-targeted CAR-NK cell therapy across a spectrum of paediatric sarcomas. The enhanced anti-tumour effects observed in vitro/vivo suggests potential for improved therapeutic outcomes in hard-to-cure paediatric sarcomas.
Addressing unmet clinical needs in paediatric Sarcomas. Paediatric sarcomas, including rhabdomyosarcoma, Ewing sarcoma, and osteosarcoma, exhibit poor survival rates in advanced disease stages. The lack of significant therapeutic progress over the past three decades necessitates innovative treatment approaches. Advancing immunotherapy with CAR-NK cells. Natural killer (NK) cells modified with chimeric antigen receptors (CARs) represent a promising strategy to overcome the limitations of CAR-T cells, particularly in solid tumours. CAR-NK cells are associated with enhanced tumour targeting, reduced off-target effects, and improved safety profiles. EphA2 as a therapeutic target. EphA2, a receptor overexpressed in multiple paediatric sarcomas, is identified as a viable target for CAR-based immunotherapy due to its critical role in tumour progression and angiogenesis. Innovations in mRNA-based engineering. This study demonstrates the feasibility of transient mRNA transfection to engineer NK cells for CAR expression, offering a non-integrative and safer alternative to viral transduction. Enhancements in mRNA stability through chemical modifications, can further optimise protein expression. Preclinical efficacy of EphA2-CAR NK cells. EphA2-specific CAR-NK cells exhibit superior cytotoxicity against sarcoma cell lines in vitro and demonstrate significant anti-tumour activity in in vivo mouse models of rhabdomyosarcoma and osteosarcoma. Clinical translation potential. The findings establish a strong preclinical rationale for the clinical evaluation of EphA2-targeted CAR-NK therapy as a novel immunotherapeutic option for paediatric sarcomas. Future research directions: Combining EphA2-CAR NK cells with immune checkpoint inhibitors or other immunomodulatory agents could further enhance therapeutic outcomes and durability. Advanced preclinical models mimicking human tumour microenvironments are needed to refine and optimise this therapeutic approach. | [
0.029741927981376648,
0.03454483300447464,
0.030598783865571022,
0.02126356214284897,
-0.019978277385234833,
-0.014656749553978443,
-0.00020522973500192165,
0.019718965515494347,
0.02613411284983158,
-0.011454814113676548,
0.009042087011039257,
-0.07919154316186905,
-0.05610152706503868,
0.004416754934936762,
0.014701846987009048,
-0.012255297973752022,
0.03262817859649658,
-0.0161787960678339,
0.020609645172953606,
-0.007305826060473919,
0.03704775497317314,
0.002202740404754877,
0.003602178068831563,
-0.0004939606296829879,
-0.0026508986484259367,
-0.044376127421855927,
0.039866358041763306,
-0.009904580190777779,
-0.014611652120947838,
-0.03398111090064049,
0.03035074658691883,
-0.0063813235610723495,
-0.024194911122322083,
-0.020519450306892395,
-0.0066800955682992935,
0.013360191136598587,
0.020519450306892395,
0.007830087095499039,
-0.04757806286215782,
-0.02809586189687252,
0.07517784833908081,
-0.01038938108831644,
0.010795259848237038,
0.07589941471815109,
-0.08721893280744553,
0.006195295602083206,
-0.040069300681352615,
-0.04496239870786667,
0.03228994831442833,
-0.015660174190998077,
0.0019279263215139508,
0.022436100989580154,
-0.02240227907896042,
0.03946048021316528,
-0.05749955773353577,
0.042233988642692566,
-0.01611115038394928,
0.015896936878561974,
-0.004915648605674505,
-0.007356560789048672,
0.007869547232985497,
-0.00752567732706666,
0.02349589765071869,
-0.018557699397206306,
-0.06710536777973175,
0.008066849783062935,
-0.04315849021077156,
-0.01393518690019846,
-0.004165899474173784,
0.03711539879441261,
0.048570211976766586,
0.004388568922877312,
-0.009893306531012058,
0.010874181054532528,
0.010716338641941547,
-0.03371052443981171,
-0.0032836757600307465,
0.02615666203200817,
0.013382740318775177,
0.017745941877365112,
0.02624685689806938,
-0.005496281199157238,
0.022075319662690163,
-0.031365443021059036,
0.0007363607292063534,
-0.03159093111753464,
0.012176376767456532,
-0.04956236481666565,
-0.044150639325380325,
0.005758411716669798,
-0.022920900955796242,
0.02171453833580017,
-0.033530134707689285,
0.044150639325380325,
0.015491057187318802,
0.05997993052005768,
-0.015479782596230507,
-0.033755622804164886,
0.07797390967607498,
0.012277846224606037,
0.042279087007045746,
0.005986718460917473,
-0.024104716256260872,
-0.013529307208955288,
0.026179209351539612,
0.06227991357445717,
-0.04252712428569794,
0.01695673167705536,
0.025254707783460617,
-0.017486630007624626,
0.01385626569390297,
-0.013484209775924683,
0.004515406209975481,
0.044015347957611084,
-0.02385667897760868,
-0.06264069676399231,
-0.035198748111724854,
-0.026788027957081795,
-0.0019448379753157496,
0.06557204574346542,
-0.030576234683394432,
0.037363436073064804,
0.005744318477809429,
-0.0105979572981596,
0.006099462974816561,
-0.03188406676054001,
0.03725069388747215,
0.010761437006294727,
-0.004273006226867437,
-0.07265238463878632,
0.029719378799200058,
0.016719968989491463,
0.026833126321434975,
0.003145563881844282,
-0.050960391759872437,
0.024375302717089653,
0.007756802719086409,
-0.02996741607785225,
-0.033552683889865875,
0.037408534437417984,
0.011528097093105316,
0.0027072709053754807,
-0.033349741250276566,
-0.024082167074084282,
-0.04268496483564377,
-0.022221887484192848,
0.016370462253689766,
0.013574405573308468,
-0.005569565109908581,
0.024848828092217445,
-0.03262817859649658,
0.037566378712654114,
0.06990142166614532,
0.013867540284991264,
0.0181179977953434,
-0.017915058881044388,
-0.00635877437889576,
0.04250457510352135,
-0.03037329576909542,
-0.04924667999148369,
-0.044128090143203735,
0.046180035918951035,
-0.019267989322543144,
-0.016528304666280746,
0.02577333152294159,
0.011528097093105316,
-0.02148905023932457,
0.017554275691509247,
-0.05772504583001137,
0.018771914765238762,
0.005896523129194975,
-0.03928009048104286,
-0.03416150063276291,
0.001109826029278338,
-0.03664187341928482,
-0.029313499107956886,
0.03226739913225174,
0.015524880029261112,
-0.033462487161159515,
-0.026788027957081795,
0.022323356941342354,
0.021105719730257988,
0.014431261457502842,
0.03700265660881996,
-0.015705270692706108,
0.03810754790902138,
-0.008512189611792564,
0.0006863304879516363,
-0.02807331271469593,
-0.0160660520195961,
0.011184227652847767,
-0.013799893669784069,
0.06088188290596008,
0.01418322417885065,
0.002936987206339836,
-0.01181559544056654,
0.029741927981376648,
0.031094858422875404,
-0.01939200796186924,
-0.03501835837960243,
0.03005761094391346,
-0.019087597727775574,
0.0019152426393702626,
-0.031365443021059036,
-0.003103284863755107,
-0.03481541946530342,
-0.04462416470050812,
0.012728823348879814,
-0.01025408785790205,
-0.012751372531056404,
0.05366625264286995,
0.02169198915362358,
-0.010908003896474838,
0.015693996101617813,
-0.04054282605648041,
-0.050960391759872437,
-0.04128693789243698,
0.051005490124225616,
0.028637034818530083,
-0.026585089042782784,
-0.027216456830501556,
0.011590106412768364,
-0.04304574802517891,
0.008641845546662807,
-0.03204191103577614,
-0.0005027687875553966,
0.017328787595033646,
-0.0341840498149395,
-0.01679888926446438,
-0.03452228382229805,
0.010851631872355938,
0.037566378712654114,
0.031568385660648346,
-0.03210955485701561,
-0.017058201134204865,
-0.014194498769938946,
0.010592320002615452,
0.022233162075281143,
0.006629360839724541,
0.004199722316116095,
0.029381146654486656,
-0.005572383292019367,
0.012074907310307026,
0.020406706258654594,
-0.010953102260828018,
-0.009459240362048149,
-0.008128859102725983,
-0.07508765906095505,
0.006527890916913748,
-0.026990968734025955,
0.0020068471785634756,
0.02180473320186138,
0.005789416376501322,
-0.01396900974214077,
-0.003309043124318123,
-0.013112153857946396,
0.022064045071601868,
-0.004191266838461161,
0.008822236210107803,
-0.00016603349649813026,
0.014273419044911861,
0.010355557315051556,
-0.013923912309110165,
-0.05988973379135132,
-0.04730748012661934,
0.008540375158190727,
0.017531728371977806,
0.04358691722154617,
0.037634022533893585,
-0.02778017707169056,
0.04302319884300232,
0.022041495889425278,
0.0029031638987362385,
-0.035334039479494095,
-0.061738740652799606,
0.03292131423950195,
-0.011781771667301655,
-0.0036839176900684834,
0.0036670060362666845,
0.009521249681711197,
-0.008095035329461098,
0.012221474200487137,
0.005783779080957174,
-0.03468012437224388,
-0.02376648411154747,
-0.012480786070227623,
0.0129317631945014,
0.0032216664403676987,
-0.0341840498149395,
-0.03174877539277077,
-0.005563927814364433,
-0.03727324306964874,
-0.03693500906229019,
-0.02077876217663288,
-0.013416563160717487,
-0.004089796915650368,
0.02059837058186531,
-0.03664187341928482,
-0.019888082519173622,
0.06742104887962341,
-0.02554784156382084,
0.016686145216226578,
-0.0106543293222785,
-0.05384664237499237,
-0.006843574810773134,
0.022932175546884537,
0.02771253138780594,
0.00882787350565195,
0.01838858425617218,
0.04951726645231247,
0.020429253578186035,
0.003898131661117077,
-0.0023112567141652107,
0.002178782131522894,
0.016505755484104156,
-0.011781771667301655,
0.04911138489842415,
-0.03632619231939316,
0.012108730152249336,
-0.010338645428419113,
-0.03722814470529556,
0.001703847199678421,
-0.05601133406162262,
-0.017926331609487534,
-0.021522874012589455,
-0.031072309240698814,
0.020045923069119453,
0.015637625008821487,
0.04942706972360611,
-0.037385985255241394,
0.003985508345067501,
-0.052358418703079224,
0.04088105633854866,
-0.035131100565195084,
0.022616492584347725,
-0.012108730152249336,
-0.0010034235892817378,
-0.05425252392888069,
0.0283664483577013,
0.01173667423427105,
0.016731243580579758,
-0.01177049707621336,
-0.0024606427177786827,
0.05019373074173927,
0.010113157331943512,
-0.04049772769212723,
-0.04340652748942375,
0.04015949368476868,
-0.0020237588323652744,
0.07414060831069946,
-0.0027227732352912426,
0.03882911428809166,
0.02162434346973896,
0.04381240904331207,
0.017915058881044388,
0.009166105650365353,
0.00008821355004329234,
-0.012943037785589695,
-0.007548226043581963,
0.01179304625838995,
-0.008574198931455612,
-0.006826662924140692,
-0.059438757598400116,
0.059077974408864975,
0.03456738218665123,
0.031004663556814194,
-0.0015319122467190027,
0.039640869945287704,
-0.024059617891907692,
-0.041692815721035004,
-0.01649448089301586,
0.019651319831609726,
0.04117419198155403,
0.020203765481710434,
-0.01301068440079689,
0.0282537043094635,
-0.012277846224606037,
0.007627147249877453,
0.017373885959386826,
0.0391898937523365,
0.05348586291074753,
0.007334012072533369,
-0.0011133492225781083,
-0.052944689989089966,
-0.029719378799200058,
0.031230151653289795,
0.00988766923546791,
-0.023270409554243088,
-0.05019373074173927,
0.04969765618443489,
-0.002392996335402131,
-0.004929741378873587,
-0.009013901464641094,
0.02231208235025406,
-0.01408175379037857,
0.054974086582660675,
-0.01631408929824829,
0.06065639480948448,
0.05366625264286995,
0.020801309496164322,
-0.014250870794057846,
-0.0467212088406086,
-0.00047528737923130393,
-0.013134703040122986,
0.009442329406738281,
-0.026539990678429604,
0.0037261967081576586,
0.024330204352736473,
0.04369966313242912,
-0.008675668388605118,
-0.022887079045176506,
-0.01644938252866268,
0.03621344640851021,
0.01502880547195673,
0.0457967072725296,
-0.022796882316470146,
-0.028794875368475914,
0.041985951364040375,
-0.03407130762934685,
0.037476181983947754,
0.04568396136164665,
-0.0685935914516449,
-0.021184640005230904,
-0.011612655594944954,
0.020947877317667007,
0.011838143691420555,
0.023270409554243088,
-0.015333214774727821,
0.011043297126889229,
-0.004287099465727806,
-0.022052770480513573,
0.06457989662885666,
-0.0014367842813953757,
-0.0471721850335598,
0.0037741130217909813,
0.012537158094346523,
-0.02021504007279873,
0.018941029906272888,
-0.013867540284991264,
0.04340652748942375,
-0.015648899599909782,
-0.008833509869873524,
-0.02189492993056774,
-0.0238115806132555,
0.031049760058522224,
-0.011229325085878372,
-0.02144395187497139,
0.06895437091588974,
-0.06530145555734634,
-0.0015375494258478284,
0.011973436921834946,
-0.01964004524052143,
0.010124431923031807,
0.00002695291732379701,
0.00293980585411191,
-0.01925671473145485,
0.04081341251730919,
-0.06566224247217178,
0.0005598455900326371,
0.017723392695188522,
0.04525553435087204,
-0.03894185647368431,
-0.01640428602695465,
-0.02007974684238434,
0.007706067990511656,
0.0066800955682992935,
0.015265568159520626,
-0.02374393492937088,
0.002160461386665702,
-0.035086002200841904,
0.011308246292173862,
-0.05005843937397003,
-0.040024202316999435,
0.012706274166703224,
-0.0019631588365882635,
0.048074137419462204,
-0.015806740149855614,
0.0010076515609398484,
0.024600790813565254,
0.051050588488578796,
-0.02294345013797283,
-0.01086854375898838,
-0.01930181123316288,
-0.02561548911035061,
0.02338315360248089,
-0.03860362246632576,
-0.005403267219662666,
0.024713534861803055,
-0.008173956535756588,
0.03946048021316528,
-0.003086373209953308,
0.00431810412555933,
0.025164511054754257,
-0.009098459035158157,
-0.037543829530477524,
-0.03652913123369217,
-0.004343471489846706,
0.00493256002664566,
-0.04433102905750275,
0.02773508056998253,
-0.016235169023275375,
0.006026179064065218,
-0.0035063454415649176,
0.02568313479423523,
0.03037329576909542,
0.030779173597693443,
-0.008715128526091576,
0.05402703583240509,
-0.024082167074084282,
0.0280282162129879,
-0.04577415809035301,
0.004907192662358284,
0.008083761669695377,
-0.0008829282596707344,
-0.009690366685390472,
-0.03456738218665123,
-0.037859510630369186,
-0.015592526644468307,
-0.004568960051983595,
-0.017418982461094856,
0.0076609705574810505,
-0.014983708038926125,
0.003306224476546049,
0.0009583259234204888,
0.005817602388560772,
-0.021985124796628952,
-0.05569564923644066,
-0.046112388372421265,
-0.03296641260385513,
-0.0353114940226078,
0.026833126321434975,
-0.008822236210107803,
0.02274051122367382,
0.03298896178603172,
-0.045864351093769073,
-0.004859276115894318,
-0.01975278928875923,
0.0009322538389824331,
-0.022064045071601868,
-0.025525294244289398,
-0.008281063288450241,
-0.01416067499667406,
0.026359600946307182,
0.009273212403059006,
0.00299617787823081,
0.02041797898709774,
0.014262145385146141,
-0.003466885071247816,
-0.0018856471870094538,
-0.007655333261936903,
0.0017954518552869558,
-0.029200755059719086,
0.009075910784304142,
0.0019800704903900623,
-0.0035909037105739117,
0.0066011748276650906,
0.004185629542917013,
-0.008839147165417671,
0.010908003896474838,
-0.003619089722633362,
-0.038017354905605316,
0.0202826876193285,
0.02066601626574993,
-0.0283664483577013,
-0.039595771580934525,
0.009447966702282429,
0.0016404285561293364,
0.007463668007403612,
-0.03688991069793701,
0.06079168990254402,
-0.006792839616537094,
-0.0016404285561293364,
0.026990968734025955,
-0.05578584596514702,
0.050329022109508514,
-0.02182728238403797,
-0.031072309240698814,
0.029741927981376648,
-0.021150818094611168,
0.0005182711174711585,
-0.024781182408332825,
0.0009780562249943614,
0.005256699863821268,
0.050374120473861694,
-0.02624685689806938,
0.014397437684237957,
-0.017971429973840714,
-0.025322353467345238,
-0.003965778276324272,
0.026562539860606194,
0.04099380224943161,
-0.021049346774816513,
0.021883655339479446,
0.014949885196983814,
-0.03808499872684479,
0.004509769380092621,
0.018309662118554115,
-0.008286700583994389,
-0.006060002371668816,
-0.010535947978496552,
0.01187196746468544,
0.0013324958272278309,
-0.015964582562446594,
-0.015310666523873806,
-0.01907632313668728,
0.03391346335411072,
0.009853845462203026,
-0.02791547030210495,
0.01850132830440998,
0.01865917071700096,
0.006623723544180393,
0.02155669592320919,
-0.024397851899266243,
0.020880231633782387,
0.03044094145298004,
0.0026692196261137724,
-0.007531314622610807,
-0.01679888926446438,
0.01720476895570755,
-0.013529307208955288,
-0.004718346055597067,
-0.0214214026927948,
-0.0113928047940135,
0.029561536386609077,
-0.0006472223321907222,
-0.0394153818488121,
-0.016032230108976364,
0.007463668007403612,
0.027554688975214958,
-0.024262558668851852,
0.033823270350694656,
-0.050374120473861694,
-0.012041083537042141,
0.02242482639849186,
-0.013529307208955288,
-0.019606221467256546,
0.012728823348879814,
-0.025187060236930847,
-0.010473938658833504,
0.009442329406738281,
-0.017791040241718292,
0.011556283570826054,
0.015445959754288197,
-0.03903205320239067,
0.0027805545832961798,
-0.030643882229924202,
-0.01722731813788414,
0.03265072777867317,
0.004707071464508772,
-0.01626899279654026,
-0.011116581037640572,
-0.0017123030265793204,
0.01168030221015215,
-0.02146650105714798,
0.006443332880735397,
-0.024623339995741844,
-0.004041880834847689,
-0.015491057187318802,
0.04978785291314125,
0.05159175768494606,
-0.0214214026927948,
0.007722979877144098,
-0.015615075826644897,
-0.026923321187496185,
0.0020956334192305803,
-0.004072885494679213,
0.012999409809708595,
0.013664600439369678,
-0.0006771699991077185,
-0.010130069218575954,
0.07350923866033554,
0.007835723459720612,
0.008878608234226704,
-0.01695673167705536,
-0.0021210007835179567,
-0.016393011435866356,
0.006753379479050636,
-0.00030370475724339485,
-0.027487043291330338,
0.04090360552072525,
0.021139543503522873,
0.008495277725160122,
0.005315890535712242,
-0.06899946928024292,
-0.002030805451795459,
-0.0106543293222785,
-0.015772918239235878,
0.01863662153482437,
0.010964375920593739,
-0.00484800199046731,
0.005042485427111387,
-0.03822029381990433,
-0.024848828092217445,
-0.003700829343870282,
0.018986128270626068,
0.031252700835466385,
0.0013564539840444922,
-0.0026227126363664865,
-0.023225311189889908,
-0.10859524458646774,
0.025074316188693047,
0.009797473438084126,
-0.002604391658678651,
-0.024149814620614052,
0.00347252213396132,
-0.01905377395451069,
-0.0040221503004431725,
-0.018783189356327057,
0.020091021433472633,
0.04065556824207306,
-0.007762440014630556,
-0.025750782340765,
-0.008472728542983532,
-0.03603305667638779,
-0.01491606142371893,
-0.016009680926799774,
-0.0014050749596208334,
0.02615666203200817,
0.001343770301900804,
0.006403872277587652,
-0.012311669997870922,
-0.01064305566251278,
0.001314174965955317,
-0.022244436666369438,
0.021015524864196777,
0.020970426499843597,
-0.028907619416713715,
0.05533486604690552,
-0.007604598067700863,
-0.0035768107045441866,
-0.004766262136399746,
-0.015367038547992706,
-0.024037068709731102,
-0.006347500253468752,
-0.04606729373335838,
0.022819431498646736,
-0.03612324967980385,
-0.0026241219602525234,
-0.0023450800217688084,
0.004487220197916031,
0.04029478877782822,
-0.06453479826450348,
-0.021319933235645294,
0.0036106340121477842,
-0.009391594678163528,
0.01711457408964634,
0.02059837058186531,
0.0030525499023497105,
0.01410430297255516,
-0.01011879462748766,
0.009357770904898643,
0.00702396547421813,
-0.024172361940145493,
0.0113928047940135,
-0.003822029335424304,
-0.020959151908755302,
0.0026959963142871857,
-0.003528894390910864,
-0.02593117207288742,
-0.04103890061378479,
-0.024307655170559883,
0.021004250273108482,
-0.02559293992817402,
-0.005205964669585228,
0.016810163855552673,
0.008991352282464504,
0.031365443021059036,
0.010457026772201061,
-0.027216456830501556,
0.024984121322631836,
-0.010192078538239002,
-0.008376896381378174,
0.012334218248724937,
-0.008788412436842918,
-0.0008138723787851632,
0.0016066052485257387,
-0.04135458171367645,
0.008061212487518787,
-0.0015995587455108762,
0.0280282162129879,
-0.017847411334514618,
-0.006956318859010935,
0.023135116323828697,
-0.0041518062353134155,
0.011048934422433376,
-0.046405524015426636,
-0.009295761585235596,
0.009526886977255344,
-0.03596540912985802,
-0.02077876217663288,
-0.015784192830324173,
0.008608021773397923,
-0.021455226466059685,
0.04139968007802963,
-0.010457026772201061,
0.0007102886447682977,
0.005510373972356319,
-0.06007012352347374,
0.00826978962868452,
0.0035204384475946426,
-0.02838899753987789,
-0.005518829915672541,
0.00257197767496109,
-0.035198748111724854,
-0.0064602443017065525,
0.019380733370780945,
-0.03039584495127201,
0.03271837532520294,
-0.010017325170338154,
-0.00481981597840786,
-0.0030835545621812344,
-0.01909887231886387,
-0.03224484995007515,
-0.004335015546530485,
-0.03898695483803749,
-0.022977273911237717,
0.014341065660119057,
0.0023704473860561848,
0.009278849698603153,
0.01973024010658264,
0.03447718545794487,
-0.009357770904898643,
0.015569978393614292,
0.0020702658221125603,
0.004650699440389872,
-0.026494894176721573,
-0.029651733115315437,
-0.01647193171083927,
0.005896523129194975,
-0.004292736295610666,
0.037836961448192596,
-0.019245440140366554,
-0.03925754129886627,
-0.003968596924096346,
-0.02019249089062214,
0.006640634965151548,
0.01722731813788414,
0.012897939421236515,
0.0057245884090662,
0.00909282173961401,
0.0031371081713587046,
-0.010130069218575954,
-0.020835133269429207,
-0.0038276666309684515,
0.01383371651172638,
0.03434189036488533,
-0.008506552316248417,
0.011353343725204468,
-0.04313594102859497,
-0.024826278910040855,
-0.013337641954421997,
-0.010276636108756065,
-0.029651733115315437,
0.0031822058372199535,
0.010936190374195576,
0.014577828347682953,
-0.010964375920593739,
-0.03012525849044323,
0.03183896839618683,
0.018332211300730705,
0.008173956535756588,
-0.024217460304498672,
-0.0043124668300151825,
-0.033169351518154144,
0.013957735151052475,
-0.012492060661315918,
0.0074411192908883095,
0.008946254849433899,
0.024758633226156235,
-0.04744277149438858,
0.023247860372066498,
-0.005769685842096806,
-0.000682807236444205,
0.00045802342356182635,
-0.007249454036355019,
0.0003991850244347006,
0.021500324830412865,
-0.022345906123518944,
-0.04996824264526367,
-0.03725069388747215,
0.010406292043626308,
-0.03833303600549698,
0.0019800704903900623,
0.006133286282420158,
0.037588924169540405,
0.018287114799022675,
-0.016054777428507805,
-0.000977351563051343,
-0.022796882316470146,
-0.0055611091665923595,
0.0015389587497338653,
-0.0016939820488914847,
-0.004433666821569204,
0.016968006268143654,
-0.0015544610796496272,
0.024961572140455246,
-0.048074137419462204,
0.029065461829304695,
-0.03447718545794487,
-0.018862109631299973,
-0.03028309904038906,
-0.008489640429615974,
0.01722731813788414,
0.0319066159427166,
0.044150639325380325,
-0.012131279334425926,
-0.0029792662244290113,
0.03679971769452095,
0.012537158094346523,
-0.00635877437889576,
0.000734246801584959,
-0.006217844318598509,
0.018422406166791916,
0.011150403879582882,
-0.019820434972643852,
-0.01798270456492901,
0.021793458610773087,
0.027148811146616936,
0.010659966617822647,
0.02604391612112522,
0.02568313479423523,
-0.010744525119662285,
-0.010169529356062412,
-0.01497243344783783,
0.011009474284946918,
0.004678885452449322,
-0.002545200986787677,
-0.011466087773442268,
-0.014634201303124428,
0.013608228415250778,
-0.012672451324760914,
-0.018196918070316315,
0.025096865370869637,
0.04347417503595352,
0.02387922815978527,
0.008106309920549393,
0.000019521046851878054,
-0.013157251290977001,
-0.006809751503169537,
0.0070014167577028275,
0.0106543293222785,
0.03495071083307266,
0.008405081927776337,
-0.06525635719299316,
0.024533145129680634,
0.037431083619594574,
-0.027532139793038368,
-0.008517826907336712,
0.02823115512728691,
0.035514432936906815,
0.04478200897574425,
-0.015378313139081001,
0.024442948400974274,
0.0038784013595432043,
0.0013134703040122986,
-0.027577238157391548,
0.020406706258654594,
-0.028501741588115692,
0.03682226687669754,
-0.06065639480948448,
-0.0025184242986142635,
-0.01763319782912731,
-0.01014134380966425,
-0.029336048290133476,
-0.0024324567057192326,
0.04708198830485344,
0.028614485636353493,
-0.00296799186617136,
-0.04153497517108917,
0.03528894484043121,
-0.0036839176900684834,
0.012198925949633121,
0.009927129372954369,
0.03445463627576828,
0.04103890061378479,
0.011725399643182755,
0.010225901380181313,
-0.01916651800274849,
-0.007627147249877453,
0.0353114940226078,
0.007458030711859465,
0.03474777191877365,
-0.0035937223583459854,
-0.012593530118465424,
-0.0033456850796937943,
0.050464317202568054,
0.00797665398567915,
-0.031185053288936615,
-0.03023800253868103,
-0.01493861060589552,
0.03909969702363014,
0.03925754129886627,
-0.017813587561249733,
-0.03835558518767357,
-0.008343072608113289,
-0.01973024010658264,
-0.008940617553889751,
0.004625332076102495,
0.006787202786654234,
0.05610152706503868,
-0.0013902772916480899,
-0.03454483300447464,
0.026742931455373764,
-0.00018726111738942564,
-0.04358691722154617,
-0.008703854866325855,
0.05961914733052254,
0.003723378060385585,
0.022481199353933334,
-0.03251543641090393,
0.02155669592320919,
0.0036500943824648857,
0.01832093670964241,
-0.016573401167988777,
0.010817809030413628,
-0.022086594253778458,
-0.02363119088113308,
-0.05141136795282364,
-0.022864529862999916,
-0.023270409554243088,
-0.018783189356327057,
0.015378313139081001,
0.0037684759590774775,
0.033530134707689285,
0.03641638532280922,
0.00984257087111473,
0.012390591204166412,
-0.027103712782263756,
0.033462487161159515,
-0.02584097720682621,
0.018895933404564857,
0.03021545335650444,
-0.01192833948880434,
-0.01916651800274849,
-0.02372138574719429,
0.00789773277938366,
0.004106708336621523,
0.04072321578860283,
-0.01025408785790205,
-0.010631781071424484,
-0.028659582138061523,
-0.01711457408964634,
-0.0004319513391237706,
0.052583906799554825,
-0.01404793094843626,
-0.013698424212634563,
0.002708679996430874,
-0.023225311189889908,
-0.009442329406738281,
0.03858107328414917,
0.012232748791575432,
0.024420399218797684,
0.02010229602456093,
0.01175922341644764,
-0.009836933575570583,
0.020812584087252617,
0.006612448953092098,
0.007756802719086409,
-0.005008662585169077,
-0.018512602895498276,
-0.010851631872355938,
0.029088011011481285,
0.009746738709509373,
0.027554688975214958,
-0.008484003134071827,
0.04241437837481499,
0.04516533762216568,
0.028704680502414703,
0.016505755484104156,
-0.00511576933786273,
-0.009803110733628273,
-0.024397851899266243,
-0.018343485891819,
0.015378313139081001,
-0.02768998220562935,
0.050374120473861694,
-0.021319933235645294,
0.028591936454176903,
0.0064602443017065525,
0.0036839176900684834,
0.009143557399511337,
0.019087597727775574,
0.01175922341644764,
-0.04070066660642624,
-0.014273419044911861,
-0.0028341079596430063,
-0.01642683334648609,
-0.04521043598651886,
0.013799893669784069,
-0.02151159942150116,
-0.025525294244289398,
0.010400654748082161,
-0.02383412979543209,
0.027374299243092537,
-0.012683725915849209,
0.011838143691420555,
-0.029516439884901047,
0.018929755315184593,
0.024690985679626465,
-0.031297799199819565,
0.010665603913366795,
0.007632784079760313,
-0.03267327696084976,
-0.030891919508576393,
-0.06029561534523964,
0.035221297293901443,
-0.010930553078651428,
-0.04309084266424179,
-0.003853033995255828,
0.015412135981023312,
-0.025096865370869637,
0.033823270350694656,
0.003117377869784832,
-0.035536982119083405,
0.0028115592431277037,
0.02789292298257351,
0.007914644666016102,
0.0128190191462636,
0.003162475535646081,
-0.0038784013595432043,
0.011917064897716045,
-0.03860362246632576,
0.0014078936073929071,
0.0033344104886054993,
-0.008794049732387066,
-0.02985467202961445,
-0.03298896178603172,
0.011110943742096424,
-0.010502125136554241,
0.011274422518908978,
0.015457233414053917,
0.009160468354821205,
0.028546838089823723,
0.03607815504074097,
0.004957927390933037,
-0.014138126745820045,
0.014138126745820045,
-0.04884079843759537,
-0.005267973989248276,
0.002734047593548894,
-0.0047521693632006645,
0.016325363889336586,
0.0205081757158041,
-0.017283691093325615,
0.014329791069030762,
-0.030937016010284424,
0.007164895534515381,
0.04965255782008171,
-0.00033752803574316204,
-0.03943793103098869,
0.046405524015426636,
-0.0008265561191365123,
0.002863703528419137,
-0.016235169023275375,
0.0004347699286881834,
-0.0036106340121477842,
-0.015288117341697216,
0.0003713513142429292,
0.03026055172085762,
0.017125848680734634,
-0.013078331016004086,
-0.007846998050808907,
-0.002648080000653863,
0.0025649312883615494,
-0.013788619078695774,
-0.0009054770926013589,
0.015062629245221615,
0.007644058670848608,
0.02399197220802307,
-0.03605560585856438,
-0.004467490129172802,
-0.019245440140366554,
0.008872970938682556,
0.021793458610773087,
0.03670952096581459,
0.0028594755567610264,
0.04561631381511688,
0.024352753534913063,
-0.010502125136554241,
0.021951301023364067,
0.007886459119617939,
-0.0035542617551982403,
-0.007655333261936903,
-0.05186234414577484,
-0.024285105988383293,
0.00585706252604723,
-0.001937791472300887,
-0.0011295562144368887,
0.015423410572111607,
0.03420659899711609,
-0.019470928236842155,
0.0012183423386886716,
-0.050644706934690475,
0.002378903329372406,
0.008788412436842918,
-0.012289120815694332,
0.020880231633782387,
-0.026224307715892792,
-0.010626143775880337,
0.008416356518864632,
0.00028925942024216056,
-0.0012852841755375266,
0.007305826060473919,
0.00988766923546791,
0.03456738218665123,
0.0003537350276019424,
-0.03393601253628731,
-0.02378903143107891,
0.005118587985634804,
-0.06421910971403122,
0.002604391658678651,
-0.00009539218444842845,
0.013766069896519184,
0.0011725400108844042,
-0.016122424975037575,
0.002130865817889571,
-0.007193082012236118,
-0.005795053206384182,
0.03012525849044323,
0.03449973464012146,
0.006138923112303019,
-0.008833509869873524,
0.015896936878561974,
0.0025212427135556936,
-0.01416067499667406,
-0.027532139793038368,
-0.009741101413965225,
0.0008272607810795307,
-0.012649902142584324,
-0.008985714986920357,
-0.0055611091665923595,
-0.0029792662244290113,
-0.015772918239235878,
0.011511186137795448,
0.023157665506005287,
-0.012570981867611408,
0.024285105988383293,
-0.005625937134027481,
0.01165775302797556,
0.03693500906229019,
0.00009195700840791687,
0.0035768107045441866,
-0.006961956154555082,
-0.0005880316020920873,
0.026742931455373764,
-0.0031089221592992544,
0.024420399218797684,
0.015693996101617813,
0.011364618316292763,
-0.026427246630191803,
0.007542588748037815,
-0.005896523129194975,
-0.008777137845754623,
-0.04090360552072525,
-0.0181179977953434,
0.03686736151576042,
0.016719968989491463,
-0.026697833091020584,
0.013236172497272491,
-0.003779750317335129,
0.0013339051511138678,
-0.011646478436887264,
0.00850091502070427,
-0.02401452139019966,
-0.016832713037729263,
-0.011804320849478245,
0.029448792338371277,
0.0033146804198622704,
0.015739094465970993,
0.015209196135401726,
0.024330204352736473,
0.026201758533716202,
-0.0321321040391922,
0.024623339995741844,
0.018715541809797287,
-0.015299391932785511,
0.005028392653912306,
-0.0020251681562513113,
0.042121242731809616,
-0.03177132457494736,
-0.0010590910678729415,
0.03686736151576042,
0.04018204286694527,
-0.009600170888006687,
-0.003263945458456874,
0.026990968734025955,
-0.009402868337929249,
-0.0258635263890028,
-0.024916473776102066,
-0.02568313479423523,
0.0015812377678230405,
-0.020429253578186035,
-0.002381721744313836,
0.02128611132502556,
-0.029178205877542496,
0.007886459119617939,
0.010750162415206432,
0.015299391932785511,
0.029538987204432487,
-0.0026974056381732225,
-0.029741927981376648,
0.010400654748082161,
-0.0026114382781088352,
-0.04241437837481499,
-0.06313677132129669,
0.00963963195681572,
0.004808541387319565,
-0.01909887231886387,
-0.015569978393614292,
-0.026675283908843994,
-0.0007427026284858584,
0.0012479376746341586,
-0.025029219686985016,
0.024736084043979645,
0.035604625940322876,
0.015367038547992706,
0.013506758958101273,
0.015231745317578316,
-0.004941015969961882,
-0.011358981020748615,
-0.033733073621988297,
-0.007756802719086409,
-0.035491883754730225,
0.01588566228747368,
0.03247033804655075,
-0.037882059812545776,
0.031387992203235626,
0.03420659899711609,
-0.012672451324760914,
0.022188063710927963,
-0.017712118104100227,
0.0008434677729383111,
0.028659582138061523,
-0.0039911456406116486,
0.002452187007293105,
-0.008996989578008652,
-0.025322353467345238,
-0.028794875368475914,
0.0006813979125581682,
0.013923912309110165,
0.007255091331899166,
0.04036243259906769,
0.004292736295610666,
0.014713121578097343,
-0.05010353401303291,
0.01283029280602932,
0.018907207995653152,
0.018771914765238762,
-0.011015111580491066,
0.004278643522411585,
-0.017926331609487534,
0.0006278444197960198,
-0.027081163600087166,
0.007790626026690006,
0.016393011435866356,
-0.05163685604929924,
0.0323575921356678,
0.008123221807181835,
-0.011669027619063854,
0.03005761094391346,
0.004619694780558348,
-0.007768077310174704,
0.0006556781590916216,
-0.013281269930303097,
-0.023247860372066498,
-0.03594285994768143,
-0.005727407056838274,
-0.00048127691843546927,
-0.013675875030457973,
-0.017678294330835342,
-0.010338645428419113,
-0.024939022958278656,
0.027509592473506927,
-0.020158668980002403,
0.006843574810773134,
-0.019651319831609726,
0.003089191857725382,
0.01629154197871685,
-0.007621509954333305,
-0.02394687384366989,
0.017193494364619255,
-0.03479287028312683,
-0.012514609843492508,
-0.016190070658922195,
-0.024668436497449875,
-0.017328787595033646,
-0.004526680801063776,
-0.040317337960004807,
0.007373472675681114,
0.021026799455285072,
-0.004165899474173784,
-0.004915648605674505,
0.0236988365650177,
-0.009273212403059006,
0.0410163514316082,
-0.05731916427612305,
0.0033710524439811707,
-0.001968796132132411,
0.01522047072649002,
-0.011725399643182755,
-0.03833303600549698,
-0.006443332880735397,
-0.01306705642491579,
0.0006458130083046854,
-0.03930263966321945,
-0.01524301990866661,
0.008275425992906094,
-0.02554784156382084,
0.020677290856838226,
0.00919429212808609,
0.014115577563643456,
-0.0128190191462636,
-0.00705215148627758,
-0.02604391612112522,
0.009667817503213882,
-0.004749350715428591,
-0.016528304666280746,
0.027081163600087166,
0.05831131339073181,
-0.00033330012229271233,
-0.01743025705218315,
0.0066688209772109985,
0.009656542912125587,
0.004258913453668356,
-0.005513192620128393,
-0.006883034948259592,
0.026788027957081795,
-0.020068472251296043,
0.00259734527207911,
-0.0030046335887163877,
-0.03916734457015991,
0.0037402897141873837,
-0.015175373293459415,
-0.06011522188782692,
0.008506552316248417,
-0.037453632801771164,
0.022109143435955048,
-0.0020660380832850933,
0.019087597727775574,
-0.017644472420215607,
0.008596747182309628,
-0.029493890702724457,
0.019087597727775574,
-0.010276636108756065,
-0.04266241565346718,
0.012311669997870922,
-0.016483206301927567,
-0.042279087007045746,
0.0010696608806028962,
0.0036388200242072344,
0.028727229684591293,
0.0008371258736588061,
0.02276306040585041,
-0.01959494687616825,
0.0036698246840387583,
-0.0035937223583459854,
-0.008963165804743767,
0.014476358890533447,
-0.024082167074084282,
-0.025029219686985016,
0.02820860594511032,
-0.004560504108667374,
0.041850656270980835,
0.027374299243092537,
0.005375081207603216,
-0.03619089722633362,
0.01006242260336876,
-0.016686145216226578,
0.019989551976323128,
-0.014668024145066738,
0.004101071506738663,
0.11626184731721878,
-0.018422406166791916,
-0.00006284609844442457,
-0.01493861060589552,
0.0015981494216248393,
-0.02378903143107891,
0.02980957366526127,
0.02624685689806938,
0.035198748111724854,
0.007598961237818003,
0.01825329102575779,
0.02378903143107891,
0.05001334100961685,
0.014927336014807224,
0.029020365327596664,
-0.020744938403367996,
-0.00959453359246254,
0.04469181224703789,
0.0214214026927948,
-0.00428991811349988,
0.0008505142759531736,
0.002163279801607132,
-0.018884658813476562,
0.01597585715353489,
-0.015942033380270004,
-0.010862906463444233,
0.004743713419884443,
-0.014476358890533447,
-0.013822442851960659,
-0.007238179445266724,
-0.003703647991642356,
0.013551856391131878,
0.0027298196218907833,
-0.02823115512728691,
0.024037068709731102,
-0.013754796236753464,
-0.03916734457015991,
-0.028749778866767883,
0.0015347307780757546,
0.0031540198251605034,
-0.0005454001948237419,
-0.016911635175347328,
-0.01854642480611801,
0.035536982119083405,
0.03686736151576042,
-0.024059617891907692,
-0.024420399218797684,
0.002810149919241667,
0.013596953824162483,
-0.037746768444776535,
-0.013957735151052475,
0.0036134524270892143,
0.01644938252866268,
0.003689554985612631,
-0.017610648646950722,
-0.05109568312764168,
-0.01973024010658264,
-0.02155669592320919,
0.006246030330657959,
-0.02584097720682621,
-0.03458992764353752,
0.03862617164850235,
0.030688978731632233,
-0.016595950350165367,
-0.016922907903790474
] | 2025-01-07 | 89 | 39763064 | [
"NK cells",
"unmodified NK cells",
"several paediatric sarcoma cell lines",
"sarcoma cell lines",
"Paediatric sarcomas",
"paediatric sarcomas",
"NK",
"multiple paediatric sarcomas",
"various paediatric sarcomas",
"CAR expression",
"EphA2-CAR NK cells",
"CAR-NK cells",
"solid tumours",
"CAR technology",
"CAR",
"CARs",
"significant anti-tumour activity",
"EphA2",
"Ewing sarcoma",
"human tumour microenvironments",
"improved therapeutic outcomes",
"significant therapeutic progress",
"immunosuppressive tumour microenvironments",
"poor tumour infiltration",
"EphA2-targeted CAR-NK cell therapy",
"enhanced tumour targeting",
"therapeutic outcomes",
"anti-cancer activity",
"tumour progression",
"paediatric Sarcomas"
] | [
"CAR‐NK cell therapy",
"EphA2",
"Ewing sarcoma",
"immunotherapy",
"osteosarcoma",
"paediatric sarcomas",
"rhabdomyosarcoma"
] | 0 | 10.1002/ctm2.70140 | [
"Lam",
"Omer",
"Wong",
"Tu",
"Alim",
"Rossi",
"Victorova",
"Tompkins",
"Lin",
"Mehdi",
"Choo",
"Elliott",
"Coleborn",
"Sun",
"Mercer",
"Vittorio",
"Dobson",
"McLellan",
"Brooks",
"Tuong",
"Cheetham",
"Nicholls",
"Souza-Fonseca-Guimaraes"
] | [
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.\nQueensland Children's Hospital, Brisbane, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia.\nBASE Facility, University of Queensland, St Lucia, Queensland, Australia.",
"BASE Facility, University of Queensland, St Lucia, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.\nQueensland Cyber Infrastructure Foundation Ltd (QCIF), Facility for Advanced Bioinformatics, St Lucia, Queensland, Australia.",
"Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia.\nBASE Facility, University of Queensland, St Lucia, Queensland, Australia.",
"School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.",
"Department of Microbiology and Immunology, The University of Otago, Dunedin, New Zealand.",
"Department of Microbiology and Immunology, The University of Otago, Dunedin, New Zealand.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia.\nIan Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.",
"Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia.\nBASE Facility, University of Queensland, St Lucia, Queensland, Australia.",
"Queensland Children's Hospital, Brisbane, Queensland, Australia.\nIan Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.",
"Frazer Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Queensland, Australia."
] | [
"39763064",
"33322371",
"33196879",
"26848927",
"34131316",
"33497548",
"31921698",
"38693888",
"36379852",
"20542985",
"26363055",
"31741777",
"30556159",
"33859303",
"28507811",
"34804076",
"32934330",
"38444031",
"36853475",
"32023374",
"30962163",
"34159300",
"36792706",
"30639050",
"38238616",
"23302231",
"22779406",
"33256912",
"33933160",
"38265704",
"35840426",
"25389405",
"32739874",
"33824268",
"34831119",
"32811512",
"29582409",
"28985758",
"24064975",
"32341580",
"29997940",
"32873870",
"23070117",
"34408922",
"37556118",
"37585342",
"17241664",
"25494541",
"27854147",
"33483715",
"21540550",
"29653760",
"32824699",
"39269338",
"31455725",
"22454413",
"28558674",
"30400809",
"31088844",
"36074145",
"38956379",
"34111027",
"31400197",
"29409532",
"30936185",
"38810560",
"19487422",
"28854174",
"14713107",
"32397088",
"29552579",
"34805188",
"32820035",
"32627275",
"36610812",
"38707997",
"37741706",
"33186888",
"33148882",
"32873870",
"35788086",
"36389658",
"27887866",
"9541571",
"38900051",
"14633720",
"22023526",
"29459477",
"25492700"
] | [] | 11.015425 | 6.043037 |
39762445 | 70 | The epitranscriptional factor PCIF1 orchestrates CD8 | T cell-based immunotherapies have revolutionized cancer treatment, yet durable responses remain elusive. Here we show that PCIF1, an RNA N | [
-0.00985148549079895,
0.02620866894721985,
0.0757913812994957,
0.024164021015167236,
-0.009857294149696827,
-0.030135322362184525,
0.02428019419312477,
0.041892047971487045,
0.0217011496424675,
-0.004995446652173996,
-0.009224150329828262,
0.02451254054903984,
-0.012395678088068962,
-0.014475177973508835,
0.0020083438139408827,
-0.039754461497068405,
0.06101415306329727,
0.02127130888402462,
-0.014637820422649384,
0.0781613141298294,
0.023397278040647507,
-0.017983607947826385,
-0.02848566323518753,
-0.04500548914074898,
-0.028392724692821503,
0.027138054370880127,
0.006133943796157837,
0.02781185880303383,
-0.013580644503235817,
0.007133033126592636,
0.024768121540546417,
-0.02193349599838257,
-0.01275581493973732,
-0.03132028877735138,
-0.03882507607340813,
-0.020620739087462425,
0.014312535524368286,
0.01058337651193142,
-0.029275640845298767,
0.04237997531890869,
0.03222643956542015,
0.025929853320121765,
0.02127130888402462,
0.026138965040445328,
-0.012500233948230743,
0.000750043080188334,
-0.0014325605006888509,
-0.030274730175733566,
-0.004028304945677519,
-0.014533264562487602,
-0.029391814023256302,
0.04498225450515747,
-0.037454232573509216,
0.03949888050556183,
-0.06180413067340851,
0.06171119213104248,
-0.014033719897270203,
0.031180880963802338,
-0.015613675117492676,
-0.004690492060035467,
-0.004443624056875706,
-0.021062197163701057,
-0.006732235662639141,
-0.010746018961071968,
-0.040660612285137177,
0.032110266387462616,
-0.043657880276441574,
-0.004312929231673479,
0.011030643247067928,
-0.012430530041456223,
-0.01849476993083954,
-0.03582780808210373,
-0.0005039011593908072,
0.010531098581850529,
0.07737133651971817,
0.012802284210920334,
-0.06054946035146713,
0.00904989056289196,
-0.01576470024883747,
-0.0017135543748736382,
0.03592074662446976,
-0.0006041005253791809,
0.04033532738685608,
-0.04832804203033447,
-0.013882694765925407,
-0.032110266387462616,
-0.01715877838432789,
-0.0027605651412159204,
-0.052138522267341614,
0.008097270503640175,
0.006517315283417702,
0.02544192597270012,
-0.03743099793791771,
0.034875188022851944,
-0.04584193602204323,
-0.01927313022315502,
0.00543400039896369,
-0.008277338929474354,
0.001373747829347849,
0.012767432257533073,
0.07853306829929352,
-0.024303428828716278,
-0.006778704933822155,
-0.0038627581670880318,
-0.0033341702073812485,
0.027997735887765884,
-0.04231027141213417,
0.0028012257535010576,
0.0005797767662443221,
0.021550124511122704,
0.10028068721294403,
0.010060597211122513,
-0.018947845324873924,
0.032877009361982346,
-0.040451500564813614,
-0.054183170199394226,
-0.017948755994439125,
0.000740240968298167,
0.01893622800707817,
0.04363464564085007,
0.007028477266430855,
0.04637633264064789,
0.008387703448534012,
-0.02330433949828148,
-0.028230082243680954,
-0.051673829555511475,
0.023466981947422028,
-0.011332693509757519,
-0.02340889535844326,
-0.027858328074216843,
0.03947564586997032,
-0.0270451158285141,
0.028973590582609177,
0.04014945030212402,
-0.08094947040081024,
-0.005390435457229614,
-0.021852174773812294,
0.0313899926841259,
-0.004333259537816048,
0.02978680282831192,
-0.02895035594701767,
0.006267542950809002,
0.009311280213296413,
0.030414137989282608,
0.004336163867264986,
-0.07797543704509735,
0.010577567853033543,
0.003653646446764469,
0.05841187387704849,
-0.0056198774836957455,
-0.014207979664206505,
0.01733303815126419,
0.027904797345399857,
0.017309803515672684,
-0.024698417633771896,
-0.030809126794338226,
0.002574688056483865,
0.06264057755470276,
-0.02527928352355957,
-0.01455649919807911,
-0.038220975548028946,
0.03355081379413605,
-0.03636220470070839,
-0.03933623805642128,
0.036013685166835785,
-0.0016917719040066004,
0.025372222065925598,
0.020562652498483658,
-0.05255674570798874,
0.01849476993083954,
0.004373920150101185,
-0.020028255879878998,
-0.08564286679029465,
0.013371532782912254,
-0.04370434954762459,
-0.021550124511122704,
0.007208545692265034,
0.02658042311668396,
-0.02781185880303383,
-0.034712545573711395,
-0.008846587501466274,
0.06514991819858551,
0.026859238743782043,
-0.01836697943508625,
0.014974722638726234,
-0.002041743602603674,
-0.027138054370880127,
0.02003987319767475,
-0.04695719853043556,
-0.02271185629069805,
0.025558099150657654,
0.02294420264661312,
0.04477314278483391,
0.0638023093342781,
-0.015613675117492676,
-0.012198183685541153,
0.03935947269201279,
-0.0018239188939332962,
-0.023385660722851753,
0.025418691337108612,
-0.002449801890179515,
-0.017925521358847618,
-0.0410788357257843,
-0.003612985834479332,
-0.027091585099697113,
-0.03048384189605713,
0.025186344981193542,
0.010031553916633129,
-0.02360638976097107,
0.022886116057634354,
0.011716064997017384,
0.0004243951407261193,
0.005628590472042561,
-0.027974501252174377,
-0.013545792549848557,
-0.026975411921739578,
0.01646173931658268,
0.015207068994641304,
0.048839204013347626,
-0.0008669423405081034,
0.0207020603120327,
0.0019459007307887077,
0.02962416037917137,
0.001202392391860485,
0.014184745028614998,
0.01038588210940361,
0.012744197621941566,
-0.015985429286956787,
-0.026928942650556564,
0.00489960378035903,
0.020678825676441193,
0.006017770618200302,
0.014428708702325821,
-0.003229614347219467,
-0.029995914548635483,
0.021410716697573662,
0.017855817452073097,
-0.010914470069110394,
0.04902508109807968,
-0.02390844002366066,
-0.01615968905389309,
0.03427108749747276,
0.012964926660060883,
-0.0012568485690280795,
-0.045168131589889526,
0.003125058487057686,
0.02581368014216423,
-0.030460607260465622,
-0.00010310369543731213,
-0.021387482061982155,
0.011855472810566425,
0.03599045053124428,
-0.001854414353147149,
0.009009229950606823,
-0.006494080647826195,
-0.007824263535439968,
0.04224056750535965,
-0.0007754559628665447,
0.030971769243478775,
-0.05385788530111313,
-0.01058337651193142,
-0.0010484629310667515,
-0.058923035860061646,
-0.01405695453286171,
-0.02458224445581436,
0.007260823622345924,
-0.0040021659806370735,
0.025836914777755737,
0.024721652269363403,
0.021248074248433113,
0.030460607260465622,
0.04003327712416649,
0.018610943108797073,
0.03420138359069824,
-0.05980595201253891,
0.0036333161406219006,
-0.0082657216116786,
0.04358817636966705,
-0.04925742745399475,
0.037547171115875244,
-0.05957360565662384,
-0.022816412150859833,
-0.028137143701314926,
-0.006186221726238728,
-0.0480956956744194,
0.0030582589097321033,
-0.020725294947624207,
0.016810258850455284,
0.002082404214888811,
-0.03599045053124428,
0.047398656606674194,
0.011007408611476421,
-0.009427453391253948,
0.006348864175379276,
0.009497157298028469,
-0.0158576387912035,
-0.011838046833872795,
-0.02581368014216423,
0.004861847497522831,
0.06937862187623978,
-0.061060622334480286,
-0.016473356634378433,
0.00015538162551820278,
-0.003732063341885805,
-0.03592074662446976,
0.03917359560728073,
-0.0065231239423155785,
-0.04795628786087036,
0.0192034263163805,
0.04865332692861557,
0.0327143669128418,
-0.004954786039888859,
0.007986905984580517,
0.01906401850283146,
-0.012082010507583618,
0.007011051289737225,
0.03008885309100151,
-0.03296994790434837,
0.04551665112376213,
-0.028532132506370544,
-0.033643752336502075,
-0.027625981718301773,
-0.049303896725177765,
0.040590908378362656,
-0.04658544436097145,
-0.010159344412386417,
0.025953087955713272,
-0.007040094584226608,
0.056320756673812866,
-0.0060990918427705765,
0.012395678088068962,
-0.029066529124975204,
0.0454237125813961,
-0.011826429516077042,
-0.008840778842568398,
-0.05348613113164902,
-0.06264057755470276,
-0.027068350464105606,
0.027300696820020676,
0.047863349318504333,
-0.02414078637957573,
0.034480199217796326,
-0.046167220920324326,
0.05093032121658325,
0.027230992913246155,
-0.012639641761779785,
-0.004272268619388342,
0.03689660131931305,
0.01622939296066761,
0.03508429974317551,
0.03552575781941414,
0.04925742745399475,
0.03712894767522812,
0.003040832933038473,
0.02250274457037449,
0.00570119870826602,
0.015067661181092262,
-0.02527928352355957,
0.018157867714762688,
0.003534568939357996,
-0.020829850807785988,
0.0017106500454246998,
-0.006151369772851467,
0.04767747223377228,
-0.027323931455612183,
0.05436904728412628,
-0.020481331273913383,
-0.0037204460240900517,
-0.04832804203033447,
-0.02788156270980835,
-0.032203204929828644,
0.04728248342871666,
0.01029875222593546,
0.014951488003134727,
0.0003252848982810974,
-0.01626424491405487,
0.019621649757027626,
0.025999557226896286,
0.01742597669363022,
0.002105638850480318,
0.018215954303741455,
0.008643284440040588,
-0.02941504865884781,
-0.017507297918200493,
-0.013964015990495682,
0.00331383990123868,
0.016519825905561447,
-0.03508429974317551,
-0.08968569338321686,
-0.008172783069312572,
0.034642841666936874,
-0.05432257801294327,
0.03048384189605713,
0.0005046272417530417,
-0.024303428828716278,
0.012128479778766632,
-0.05697132647037506,
0.058458343148231506,
0.03136675804853439,
0.011251372285187244,
-0.03743099793791771,
-0.059991829097270966,
-0.0010288587072864175,
-0.007957862690091133,
0.03278407081961632,
-0.040590908378362656,
0.038755372166633606,
-0.008044992573559284,
0.048235103487968445,
0.01375490427017212,
-0.04925742745399475,
0.00571862468495965,
0.03782598674297333,
0.021526889875531197,
0.02353668585419655,
-0.030414137989282608,
-0.0788118839263916,
0.02748657390475273,
-0.014521647244691849,
0.030995003879070282,
0.037012774497270584,
-0.001932831248268485,
-0.002159368945285678,
-0.024117551743984222,
0.023118462413549423,
0.0440761037170887,
-0.017414359375834465,
-0.007394422776997089,
-0.030739422887563705,
-0.03589751198887825,
-0.015555588528513908,
0.041055601090192795,
-0.028857417404651642,
0.01966811902821064,
-0.00397312268614769,
0.047468360513448715,
-0.034782249480485916,
0.025070171803236008,
-0.02741686999797821,
0.013406384736299515,
0.011570848524570465,
0.02818361297249794,
-0.002372837159782648,
-0.05130207538604736,
-0.0024251150898635387,
0.0045278496108949184,
-0.004106721840798855,
0.005669251084327698,
-0.016148071736097336,
-0.02310684509575367,
0.006616062484681606,
-0.02932211011648178,
-0.03689660131931305,
0.0008400772931054235,
-0.02781185880303383,
-0.01539294607937336,
0.028694774955511093,
-0.07593078911304474,
0.006778704933822155,
0.03522370755672455,
0.050000935792922974,
-0.025465160608291626,
0.021817322820425034,
-0.044029634445905685,
-0.02841595932841301,
0.04986152797937393,
0.01936606876552105,
-0.010751827619969845,
0.01582278683781624,
-0.010606611147522926,
-0.003793054260313511,
-0.022862881422042847,
-0.02330433949828148,
-0.0030669718980789185,
-0.005245218984782696,
0.041357651352882385,
0.029740333557128906,
0.026719830930233,
-0.00844579003751278,
-0.009020847268402576,
-0.016055133193731308,
-0.004545275587588549,
-0.01509089581668377,
-0.03382962942123413,
0.00830057356506586,
0.008858204819262028,
-0.015834404155611992,
0.00425774697214365,
-0.004205469042062759,
0.010170961730182171,
0.014614585787057877,
-0.009270619601011276,
0.005477565340697765,
-0.009932806715369225,
-0.025906618684530258,
-0.021979965269565582,
-0.001056449837051332,
0.02253759652376175,
-0.024930763989686966,
-0.012047158554196358,
0.0090150386095047,
0.08071712404489517,
0.030228260904550552,
-0.027928031980991364,
0.015985429286956787,
0.04591163992881775,
0.03454990312457085,
0.04014945030212402,
-0.001314935158006847,
0.007835880853235722,
0.013847842812538147,
0.019249895587563515,
0.017855817452073097,
-0.05116266757249832,
-0.012511851266026497,
0.011123581789433956,
-0.019517093896865845,
-0.0038308105431497097,
-0.01305786520242691,
-0.030065618455410004,
-0.006621871143579483,
0.013371532782912254,
0.015973811969161034,
-0.01740274205803871,
0.013418002054095268,
-0.03729159012436867,
-0.03536311537027359,
-0.021445568650960922,
-0.006302394904196262,
-0.047398656606674194,
0.023281104862689972,
-0.018808437511324883,
0.0213758647441864,
0.04014945030212402,
0.0026806960813701153,
0.007957862690091133,
-0.02490752935409546,
0.015253538265824318,
-0.009078933857381344,
-0.020922789350152016,
0.027021881192922592,
0.001300413510762155,
0.023734180256724358,
-0.02490752935409546,
-0.011111964471638203,
0.032574959099292755,
0.018041694536805153,
-0.016008663922548294,
0.012616407126188278,
0.023652859032154083,
0.034340791404247284,
0.0023060375824570656,
0.030948534607887268,
-0.02932211011648178,
0.00545142637565732,
-0.022897733375430107,
0.02080661617219448,
-0.024303428828716278,
0.033109355717897415,
0.01633394882082939,
-0.018425066024065018,
-0.005660538095980883,
0.011530187912285328,
-0.003226710017770529,
0.015834404155611992,
0.024303428828716278,
-0.00981663353741169,
-0.024256959557533264,
-0.02651071920990944,
0.019621649757027626,
-0.02688247337937355,
0.03527017682790756,
0.003308031242340803,
0.0138594601303339,
0.031343523412942886,
0.015753082931041718,
-0.03125058487057686,
0.008387703448534012,
0.013964015990495682,
0.02902005985379219,
0.021898644044995308,
-0.00019640527898445725,
-0.007754559628665447,
0.030367668718099594,
-0.0022116468753665686,
-0.0030117896385490894,
-0.007336336188018322,
-0.020330306142568588,
-0.009380984120070934,
-0.008091461844742298,
0.030112087726593018,
0.010188387706875801,
0.012779049575328827,
-0.011768342927098274,
-0.045493416488170624,
-0.00953200925141573,
-0.011024834588170052,
-0.015555588528513908,
-0.034642841666936874,
0.008469024673104286,
-0.015137365087866783,
0.012767432257533073,
-0.0009627852123230696,
-0.02748657390475273,
-0.0034503433853387833,
0.015869256108999252,
-0.02665012702345848,
-0.007307292893528938,
0.023501833900809288,
-0.04435491934418678,
0.0004429102409631014,
0.004533658269792795,
0.012244652956724167,
0.0008698466699570417,
0.027974501252174377,
-0.007173693738877773,
0.008561963215470314,
-0.004725344013422728,
-0.0016975805629044771,
-0.020411627367138863,
-0.026998646557331085,
0.005884171463549137,
-0.015753082931041718,
-0.006279160268604755,
-0.04865332692861557,
-0.047770410776138306,
-0.01566014438867569,
-0.020980875939130783,
-0.008840778842568398,
-0.0008763814112171531,
-0.0007950601866468787,
0.03169204294681549,
-0.04033532738685608,
0.0397312268614769,
0.015230303630232811,
-0.014707524329423904,
0.008846587501466274,
0.0020853085443377495,
0.007620960474014282,
-0.016275862231850624,
-0.013034630566835403,
0.005849319510161877,
-0.008869822137057781,
-0.025534864515066147,
0.02651071920990944,
0.002899972954764962,
-0.0070342859253287315,
-0.042891137301921844,
0.014777228236198425,
-0.04672485217452049,
0.0033428831957280636,
-0.04435491934418678,
0.0019531615544110537,
0.0019517093896865845,
0.00226247264072299,
-0.017646705731749535,
0.004687587730586529,
0.0003501532191876322,
0.048235103487968445,
0.038406852632761,
-0.026603657752275467,
0.030832361429929733,
0.012953309342265129,
-0.015938960015773773,
-0.0048502301797270775,
0.03329523280262947,
0.011361736804246902,
0.02050456590950489,
-0.0025979226920753717,
0.0033719264902174473,
0.09386792778968811,
0.008126313798129559,
0.052277930080890656,
-0.02207290381193161,
-0.0027547564823180437,
0.044192276895046234,
0.013476088643074036,
-0.03025149554014206,
-0.031134411692619324,
-0.001815205905586481,
-0.025999557226896286,
0.029879741370677948,
-0.05980595201253891,
-0.050837382674217224,
-0.031715277582407,
0.003801767248660326,
-0.00333126587793231,
-0.0025790445506572723,
-0.0011290580732747912,
-0.013208890333771706,
0.0007119237561710179,
-0.008242486976087093,
-0.016717320308089256,
-0.005637303460389376,
0.0014383691595867276,
-0.012569937855005264,
0.041589997708797455,
-0.011930985376238823,
-0.022049669176340103,
0.013394767418503761,
-0.009206724353134632,
0.004783430602401495,
0.029159467667341232,
0.013661965727806091,
0.02367609366774559,
-0.005852223839610815,
-0.02330433949828148,
-0.0029261119198054075,
0.02734716609120369,
0.0018268232233822346,
-0.018808437511324883,
-0.009950232692062855,
-0.029136233031749725,
-0.008596815168857574,
-0.01883167214691639,
-0.018006842583417892,
0.014115041121840477,
0.03863919898867607,
0.00021782470867037773,
0.0028709296602755785,
0.019888848066329956,
-0.010978365316987038,
0.040521204471588135,
-0.027161289006471634,
0.04168293625116348,
0.006598636507987976,
-0.02276994287967682,
0.06073533743619919,
-0.0013011395931243896,
0.013615496456623077,
-0.016938049346208572,
-0.025790445506572723,
-0.0202025156468153,
-0.022386571392416954,
-0.01466105505824089,
-0.004330355208367109,
-0.016322331503033638,
0.0066567230969667435,
-0.013139186426997185,
0.008846587501466274,
0.004089295864105225,
-0.04100913181900978,
0.00953200925141573,
0.0061223264783620834,
-0.033945802599191666,
0.011129390448331833,
0.0035287602804601192,
0.03362051770091057,
0.013998867943882942,
-0.04328612610697746,
0.008079844526946545,
0.00791139341890812,
-0.018959462642669678,
-0.015334859490394592,
0.01799522526562214,
-0.03292347863316536,
-0.020016638562083244,
0.016438504680991173,
-0.024256959557533264,
-0.024349898099899292,
-0.04114853963255882,
-0.008625858463346958,
0.01191936805844307,
-0.028067439794540405,
-0.00016908643010538071,
0.005390435457229614,
0.04688749462366104,
-0.00792881939560175,
-0.030832361429929733,
0.016589529812335968,
-0.020760146901011467,
0.005294592585414648,
-0.02250274457037449,
-0.03836038336157799,
0.031668808311223984,
0.018274040892720222,
-0.031668808311223984,
0.01733303815126419,
-0.01033360417932272,
0.005820276215672493,
0.001182788168080151,
-0.027138054370880127,
-0.03055354580283165,
-0.026836004108190536,
-0.009845676831901073,
-0.00791139341890812,
0.0012386965099722147,
0.02103896252810955,
-0.0025470969267189503,
-0.013208890333771706,
0.013836225494742393,
0.03947564586997032,
-0.013418002054095268,
0.0364086739718914,
0.012871988117694855,
0.022897733375430107,
0.015915725380182266,
-0.09665608406066895,
-0.03559546172618866,
-0.006534741260111332,
0.04061414301395416,
-0.005898693110793829,
-0.008166974410414696,
-0.015230303630232811,
-0.02895035594701767,
-0.01660114713013172,
0.012871988117694855,
0.019610032439231873,
-0.004283885937184095,
0.020527800545096397,
-0.020876320078969002,
0.0024004282895475626,
0.0018994314596056938,
0.01148952730000019,
-0.024349898099899292,
0.027370400726795197,
0.0228744987398386,
-0.04468020424246788,
0.02665012702345848,
-0.0021782470867037773,
0.023466981947422028,
0.005529843270778656,
0.02497723326086998,
-0.03378316015005112,
-0.0277189202606678,
-0.01619454100728035,
-0.023757414892315865,
0.004005070310086012,
-0.005837702192366123,
0.008271530270576477,
0.014521647244691849,
0.007318910211324692,
-0.012593172490596771,
-0.017437594011425972,
-0.014533264562487602,
0.0005155184771865606,
0.018750350922346115,
-0.002096925862133503,
-0.016078367829322815,
-0.00007383350020973012,
0.015985429286956787,
-0.02180570550262928,
-0.006749661639332771,
-0.018622560426592827,
-0.02326948754489422,
-0.00064585026120767,
-0.012476999312639236,
0.03266789764165878,
-0.013801373541355133,
-0.053114376962184906,
-0.02330433949828148,
-0.013301828876137733,
-0.009607521817088127,
-0.02043486200273037,
0.04393669590353966,
0.012384060770273209,
0.006006153300404549,
-0.037314824759960175,
0.025999557226896286,
0.0024410889018326998,
-0.0054862783290445805,
0.011088729836046696,
-0.009764355607330799,
-0.016345566138625145,
0.01873873360455036,
-0.03132028877735138,
-0.038918014615774155,
0.019087253138422966,
0.012151714414358139,
-0.056646041572093964,
0.010804105550050735,
0.005396244116127491,
-0.01840183138847351,
0.011262989602982998,
-0.01589249074459076,
-0.0035781338810920715,
0.010699549689888954,
-0.03489842265844345,
-0.0240478478372097,
0.010321986861526966,
0.023118462413549423,
-0.037918925285339355,
0.008736222982406616,
-0.01883167214691639,
0.018610943108797073,
0.015636909753084183,
-0.020620739087462425,
0.010327795520424843,
-0.012244652956724167,
-0.010374264791607857,
0.009288045577704906,
-0.007986905984580517,
0.005663442425429821,
-0.015543971210718155,
0.037314824759960175,
-0.005634399130940437,
0.012082010507583618,
0.04591163992881775,
-0.00983405951410532,
-0.020190898329019547,
-0.041427355259656906,
-0.03350434452295303,
-0.013975633308291435,
0.010624037124216557,
0.027068350464105606,
0.011599891819059849,
0.01378975622355938,
0.019679736346006393,
-0.01202392391860485,
0.022584065794944763,
-0.007818454876542091,
-0.02347859926521778,
0.002811390906572342,
0.037384528666734695,
-0.005285879597067833,
-0.018576091155409813,
-0.00491702975705266,
0.07081916928291321,
0.01279066689312458,
0.029507987201213837,
-0.018924610689282417,
-0.003392256796360016,
-0.0012125575449317694,
0.007138841785490513,
0.022549213841557503,
0.006819365546107292,
-0.03032119944691658,
0.002041743602603674,
-0.02100411057472229,
0.02030707150697708,
0.012035541236400604,
0.02534898743033409,
0.025929853320121765,
0.005770902615040541,
0.01619454100728035,
-0.007051711902022362,
-0.0025630707386881113,
0.019575180485844612,
-0.03215673565864563,
-0.021887026727199554,
-0.014300918206572533,
0.013104334473609924,
0.013185655698180199,
-0.023095227777957916,
0.051441483199596405,
-0.013487705960869789,
0.002711191540583968,
0.020829850807785988,
-0.0009453592356294394,
0.02360638976097107,
0.023931674659252167,
-0.04465696960687637,
0.020028255879878998,
0.022293632850050926,
0.010763444937765598,
-0.017530532553792,
0.044564031064510345,
-0.018808437511324883,
0.0440761037170887,
-0.01298816129565239,
-0.010246474295854568,
0.002976937685161829,
-0.007330527529120445,
-0.011309458874166012,
-0.03108794242143631,
0.038453321903944016,
0.01669408567249775,
0.021515272557735443,
-0.04735218733549118,
0.0277189202606678,
-0.015578823164105415,
-0.04286790266633034,
0.024768121540546417,
0.015265155583620071,
0.048932142555713654,
0.01572984829545021,
0.02825331687927246,
0.021782470867037773,
0.008347042836248875,
0.014266066253185272,
0.02955445647239685,
0.038523025810718536,
-0.003400969784706831,
0.03362051770091057,
-0.005033202935010195,
0.02250274457037449,
-0.029740333557128906,
0.02757951244711876,
-0.015497501939535141,
0.010798296891152859,
0.022293632850050926,
0.026766300201416016,
0.004719535354524851,
-0.03694307059049606,
0.012476999312639236,
-0.04086972400546074,
0.01569499634206295,
-0.021027345210313797,
0.03145969659090042,
0.04790981858968735,
-0.04200822114944458,
-0.04628339409828186,
0.042124394327402115,
0.005666346754878759,
-0.04210115969181061,
-0.0010274065425619483,
0.019877230748534203,
0.01977267488837242,
0.027533043175935745,
0.013673583045601845,
-0.030902065336704254,
-0.023188166320323944,
-0.008434172719717026,
-0.01893622800707817,
0.003929557744413614,
-0.061897069215774536,
-0.019319599494338036,
0.015334859490394592,
-0.027207758277654648,
0.02513987571001053,
0.01412665843963623,
-0.040126215666532516,
0.026626892387866974,
0.020585887134075165,
0.022433040663599968,
-0.027230992913246155,
0.0027315218467265368,
-0.03587427735328674,
0.029368579387664795,
0.023699328303337097,
0.013104334473609924,
0.03645514324307442,
0.0018791011534631252,
0.0015523640904575586,
-0.016752172261476517,
0.03352757915854454,
-0.013371532782912254,
0.05460139364004135,
0.003888897132128477,
-0.002679243916645646,
0.018041694536805153,
-0.0005078946123830974,
0.0323890820145607,
0.03894124925136566,
-0.02620866894721985,
0.00746412668377161,
-0.03178498148918152,
0.005355583503842354,
0.037988629192113876,
-0.009874720126390457,
0.02513987571001053,
0.04061414301395416,
0.0017295281868427992,
-0.0014586994657292962,
-0.0028491471894085407,
0.02210775576531887,
0.0192034263163805,
0.0031076325103640556,
-0.01459135115146637,
-0.004304216243326664,
0.014382239431142807,
0.024419602006673813,
-0.025906618684530258,
-0.0320637971162796,
-0.03780275210738182,
0.03545605391263962,
0.02574397623538971,
0.016217775642871857,
0.01859932579100132,
-0.019424155354499817,
-0.018680647015571594,
0.0009555243887007236,
-0.001334539381787181,
-0.026696596294641495,
-0.029229171574115753,
-0.013569027185440063,
-0.0330628864467144,
-0.0022682812996208668,
0.006749661639332771,
0.008683945052325726,
0.031970858573913574,
0.011280415579676628,
0.019493859261274338,
0.00960171315819025,
-0.04377405345439911,
0.015880873426795006,
0.00545142637565732,
-0.008469024673104286,
-0.004461050033569336,
-0.028276551514863968,
0.0008952595526352525,
-0.01576470024883747,
-0.03557222709059715,
0.015021191909909248,
0.012082010507583618,
0.014405474066734314,
-0.028532132506370544,
0.0030059809796512127,
0.0704474151134491,
-0.019946934655308723,
0.012151714414358139,
0.005419478751718998,
-0.027835093438625336,
-0.031575869768857956,
-0.035641930997371674,
0.04493578523397446,
-0.013627113774418831,
-0.040358562022447586,
0.0034764823503792286,
0.011797386221587658,
-0.009154446423053741,
-0.009206724353134632,
0.0111874770373106,
0.010002510622143745,
-0.02513987571001053,
-0.007284058257937431,
-0.007551256567239761,
-0.01669408567249775,
-0.00771389901638031,
0.015776317566633224,
-0.0034532477147877216,
-0.037454232573509216,
-0.004231608007103205,
0.024094317108392715,
-0.023954909294843674,
0.023432129994034767,
-0.0038453321903944016,
0.04781688004732132,
-0.021085431799292564,
0.032342612743377686,
-0.024187255650758743,
0.03278407081961632,
0.035943981260061264,
-0.001516059972345829,
0.0036100815050303936,
0.002599374856799841,
-0.014684289693832397,
-0.014173127710819244,
0.012349208816885948,
0.01248861663043499,
0.010089640505611897,
0.025558099150657654,
0.011141007766127586,
0.00799852330237627,
-0.001084767049178481,
-0.018750350922346115,
-0.028927121311426163,
0.05223146080970764,
-0.006952964700758457,
0.006697383709251881,
0.03710571303963661,
0.0018268232233822346,
-0.008079844526946545,
0.05004740506410599,
-0.0004781252355314791,
-0.003078589215874672,
0.0158576387912035,
-0.0038308105431497097,
0.03436402603983879,
0.017170395702123642,
-0.0063430555164813995,
0.026092495769262314,
0.005628590472042561,
-0.007684855721890926,
-0.02695217728614807,
-0.04382052272558212,
-0.013336680829524994,
-0.00037102808710187674,
0.03141322731971741,
-0.017274951562285423,
-0.02513987571001053,
-0.008509685285389423,
0.017716409638524055,
0.012012306600809097,
-0.011977454647421837,
-0.015172217041254044,
0.03392256796360016,
0.009938615374267101,
-0.02527928352355957,
-0.012116862460970879,
0.001275726710446179,
0.020911172032356262,
0.017274951562285423,
-0.02888065204024315,
-0.010531098581850529,
-0.00823086965829134,
0.008288956247270107,
-0.0010303108720108867,
0.0009010682115331292,
0.010200005024671555,
-0.002426567254588008,
-0.04263555631041527,
-0.0012336139334365726,
-0.008521302603185177,
-0.005892884451895952,
0.037152182310819626,
0.01916857436299324,
-0.04203145578503609,
-0.017809348180890083,
0.0003815562813542783,
-0.014974722638726234,
0.00830057356506586,
0.005916119087487459,
0.008585197851061821,
-0.014602968469262123,
-0.00452494528144598,
0.024094317108392715,
0.023722562938928604,
-0.008091461844742298,
-0.032737601548433304,
0.0029725811909884214,
-0.01015353575348854,
0.019040783867239952,
0.007545447908341885,
-0.011048069223761559,
0.006714809685945511,
0.00667995773255825,
-0.004205469042062759,
-0.03129705414175987,
0.01676378957927227,
0.01063565444201231,
-0.016008663922548294,
0.01029875222593546,
0.0038598538376390934,
0.008956952020525932,
-0.055949002504348755,
0.013034630566835403,
0.009415836073458195,
0.007952054031193256,
0.020086342468857765,
-0.021677915006875992,
-0.00226247264072299,
0.003575229551643133,
0.006401142105460167,
-0.0021085431799292564,
-0.0011515666265040636,
-0.00990376342087984,
-0.0037117330357432365,
0.00015529086522292346,
0.021387482061982155,
-0.000420401687733829,
-0.004013783298432827,
-0.03615309298038483,
0.0016162593383342028,
-0.015230303630232811,
0.01683349348604679,
0.020260602235794067,
0.010554333217442036,
0.03719865158200264,
0.025302518159151077,
-0.03032119944691658,
0.007121415808796883,
-0.0020301262848079205,
-0.021747618913650513,
-0.02681276947259903,
0.026255138218402863,
-0.0005195119301788509,
-0.06180413067340851,
-0.023013906553387642,
0.026301607489585876,
0.016182923689484596,
-0.016554677858948708,
0.012082010507583618,
-0.00899761263281107,
-0.02143395133316517,
-0.01736789010465145,
-0.015114130452275276,
0.007975288666784763,
-0.02513987571001053,
0.011228137649595737,
-0.008742031641304493,
0.023374043405056,
-0.011826429516077042,
0.05353260040283203,
0.005695390049368143,
0.001688867574557662,
-0.00441748509183526,
-0.020388392731547356,
-0.01405695453286171,
-0.005129045806825161,
0.0065231239423155785,
0.024930763989686966,
-0.011088729836046696,
0.00011154440289828926,
-0.018587708473205566,
0.07174855470657349,
-0.002410593442618847,
0.01572984829545021,
0.025000467896461487,
-0.01726333424448967,
0.00022327032638713717,
0.018610943108797073,
0.021677915006875992,
0.004118339158594608,
0.007092372514307499,
0.018947845324873924,
-0.007394422776997089,
0.0029711290262639523,
-0.008155357092618942,
-0.0111874770373106,
0.00518422806635499,
0.028764478862285614,
0.007742942310869694,
-0.03194762393832207,
-0.03931300342082977,
-0.01252346858382225,
-0.004077678546309471,
0.001979300519451499,
0.004202564712613821,
0.0002203659969381988,
0.03229614347219467,
0.0121865663677454,
0.03359728306531906,
-0.04214762896299362,
0.014881784096360207,
-0.02059750445187092,
0.0015218686312437057,
-0.014637820422649384,
0.04063737764954567,
0.021863792091608047,
-0.026301607489585876,
0.012035541236400604,
-0.01983076147735119,
-0.03636220470070839,
0.04651574045419693,
-0.016310714185237885,
0.0035316646099090576,
0.024303428828716278,
-0.02367609366774559,
0.04124147817492485,
-0.005733146332204342,
-0.0450751930475235,
0.039057422429323196,
-0.02146880328655243,
-0.009044081903994083,
-0.013952398672699928,
-0.0280442051589489,
-0.020028255879878998,
0.05139501392841339,
0.010478820651769638,
-0.017112309113144875,
0.004966403357684612,
0.0143590047955513,
0.018157867714762688,
-0.015102513134479523,
0.011611509136855602,
0.00370592437684536,
0.010589185170829296,
0.009909572079777718,
0.00004381453254609369,
-0.02314169704914093,
-0.020121194422245026,
-0.028137143701314926,
0.014219596982002258,
0.009648182429373264,
-0.006668340414762497,
-0.021921878680586815,
0.0016002855263650417,
0.023397278040647507,
0.006958773359656334,
-0.006029387935996056,
0.009189298376441002,
0.01010125782340765,
0.0031918580643832684,
-0.006244308315217495,
-0.032574959099292755,
0.012058775871992111,
-0.020016638562083244,
-0.013847842812538147,
-0.031715277582407,
-0.025627803057432175,
-0.03136675804853439,
0.011524379253387451,
0.0016220679972320795,
0.023490216583013535,
-0.010844766162335873,
0.001546555431559682,
-0.011663787066936493,
0.0222006943076849,
-0.008161165751516819,
-0.003653646446764469,
0.0019531615544110537,
-0.0002535842650104314,
-0.005082576535642147,
0.010856383480131626,
-0.006807748228311539,
0.015567205846309662,
-0.06054946035146713,
-0.02364124171435833,
0.03292347863316536,
-0.016113219782710075,
0.005056437570601702,
0.01582278683781624,
-0.001783258281648159,
0.024930763989686966,
-0.021956730633974075,
0.02273509092628956,
0.01843668334186077,
0.014777228236198425,
-0.010989982634782791,
-0.003299318253993988,
-0.00318895373493433,
-0.012012306600809097,
0.004870560485869646,
-0.012918457388877869,
-0.029368579387664795,
-0.01833212748169899,
-0.003746584989130497,
0.02597632259130478,
-0.0034125871025025845,
-0.0015305816195905209,
0.000974402530118823,
-0.003096015192568302,
-0.04856038838624954,
-0.006244308315217495,
0.01766994036734104,
0.02734716609120369,
0.05046562850475311,
0.029205936938524246,
-0.0045278496108949184,
0.0015363902784883976,
0.04096266254782677,
0.003926653414964676,
-0.015451032668352127,
0.0006193482549861073,
0.01589249074459076,
0.00612813513725996,
-0.012116862460970879,
0.02618543431162834,
0.01863417774438858,
-0.02003987319767475,
-0.014870166778564453,
0.0029551552142947912,
-0.027788624167442322,
0.020725294947624207,
-0.019981786608695984,
0.00636048149317503,
-0.005881267134100199,
0.007783602923154831,
0.024326663464307785,
0.000750043080188334,
-0.032946713268756866,
0.009961850009858608,
-0.0377330482006073,
-0.017472445964813232,
0.013348298147320747,
-0.020260602235794067,
0.01305786520242691,
0.03336493670940399,
0.002317654900252819,
0.009322897531092167,
0.007086563855409622,
0.030576780438423157,
0.000101106968941167,
0.015032809227705002,
-0.013476088643074036,
0.002292968099936843,
0.021027345210313797,
-0.019761057570576668,
0.012198183685541153,
0.020551035180687904,
0.0004047909169457853,
0.0192034263163805,
-0.014277683570981026,
0.047236014157533646,
-0.02718452364206314,
0.002772182459011674,
-0.0109377047047019,
0.014370622113347054,
-0.022653769701719284,
0.02567427232861519,
0.11515085399150848,
0.01225627027451992,
-0.005971301347017288,
0.05065150558948517,
-0.010960939340293407,
-0.0012357921805232763,
0.029902976006269455,
-0.0180300772190094,
-0.007493169978260994,
-0.00985148549079895,
0.023885205388069153,
-0.029995914548635483,
0.027835093438625336,
0.034340791404247284,
0.025093406438827515,
-0.012813901528716087,
0.000887272646650672,
0.04254261776804924,
-0.027788624167442322,
-0.023315956816077232,
0.024628713726997375,
0.03436402603983879,
-0.01566014438867569,
0.03255172446370125,
-0.02474488690495491,
0.03092529997229576,
-0.003125058487057686,
-0.01890137605369091,
0.0017324325162917376,
0.014451943337917328,
-0.0010063501540571451,
-0.021097049117088318,
-0.00044472544686868787,
-0.018750350922346115,
-0.06133943796157837,
0.00018306351557839662,
-0.006372098810970783,
-0.008620049804449081,
0.010989982634782791,
0.014207979664206505,
0.01599704660475254,
0.04667838290333748,
-0.007092372514307499,
0.008155357092618942,
0.00029823833028785884,
0.02217745967209339,
-0.05069797486066818,
-0.0046324054710567,
0.005410765763372183,
-0.028276551514863968,
0.019389303401112556,
0.02574397623538971,
0.023931674659252167,
-0.018192719668149948,
0.01058337651193142,
-0.0185296218842268,
0.025860149413347244,
0.017820965498685837,
0.008672327734529972,
-0.023153314366936684,
-0.0014775776071473956,
0.006842600181698799,
0.002057717414572835,
0.014475177973508835,
0.0090150386095047
] | 2025-01-07 | 58 | 39762445 | [
"cancer treatment",
"durable responses",
"RNA N",
"PCIF1",
"T cell-based immunotherapies",
"an RNA N",
"that PCIF1",
"we"
] | [] | 0 | 10.1038/s41590-024-02047-w
10.1038/s41590-021-00964-8
10.1016/j.immuni.2015.01.006
10.1158/2159-8290.CD-23-0007
10.1038/s41586-019-1805-z
10.1038/s41586-019-0979-8
10.1038/nrm.2016.132
10.1038/s41576-020-00295-8
10.1016/j.cell.2022.02.007
10.1038/257251a0
10.1016/S0021-9258(17)34652-5
10.1038/nature21022
10.1016/j.molcel.2018.08.011
10.1126/science.aav0080
10.1038/s41422-018-0117-4
10.1016/j.molcel.2019.05.030
10.1016/j.molcel.2019.06.006
10.1038/s41467-021-25683-4
10.1073/pnas.2025769118
10.1073/pnas.2210361120
10.1038/s41421-022-00395-1
10.15252/embj.2022111673
10.1172/JCI170173
10.1016/j.celrep.2020.108038
10.1038/s41591-018-0014-x
10.1038/s41568-018-0081-9
10.1038/s41573-022-00520-5
10.1038/s41577-022-00737-w
10.1016/S0022-1759(03)00010-3
10.1038/s41467-021-25105-5
10.1016/j.ymeth.2021.10.001
10.1016/j.cell.2012.03.042
10.1080/15548627.2016.1187366
10.1038/cr.2016.95
10.1002/eji.1830230737
10.1038/s41571-020-00462-0
10.1038/s41580-020-00324-8
10.1038/s41571-019-0297-y
10.1038/s43018-022-00484-w
10.1126/scitranslmed.abn7336
10.1016/j.ymthe.2023.09.021
10.1158/1078-0432.CCR-18-2035
10.1038/s41591-019-0421-7
10.1038/s43018-023-00570-7
10.1126/scitranslmed.3010162
10.1016/j.cell.2018.10.038
10.1038/s41591-022-01799-y
10.1158/2159-8290.CD-20-1677
10.1083/jcb.202307002
10.1016/j.molcel.2019.09.032
10.1158/2326-6066.CIR-20-0384
10.1016/j.cmet.2021.02.015
10.1038/nature13954
10.1038/s41573-018-0007-y
10.1016/j.molcel.2024.01.024
10.1038/s41467-023-38605-3
10.1371/journal.pone.0096801
10.1021/acssensors.1c00496
10.1038/nature25015 | [
"Xiang",
"Zhang",
"Li",
"Zhang",
"Liu",
"Gao",
"Wang",
"Xiao",
"Sun",
"He",
"Shi",
"Fan",
"Xing",
"Xu",
"Yao",
"Chen",
"Zhu",
"Yi",
"Zhang"
] | [
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.",
"State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.\nAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.\nPeking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.",
"Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, China.",
"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China.",
"Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China. [email protected].\nState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China. [email protected].\nDepartment of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, China. [email protected].",
"Institute of Biology and Medicine, College of Life and Health Sciences, Wuhan University of Science and Technology, Wuhan, China. [email protected].",
"State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China. [email protected].\nPeking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. [email protected].\nBeijing Advanced Center of RNA Biology (BEACON), Peking University, Beijing, China. [email protected].",
"Department of Radiation and Medical Oncology, Medical Research Institute, Frontier Science Center of Immunology and Metabolism, Hubei Key Laboratory of Tumor Biological Behavior, Hubei Provincial Clinical Research Center for Cancer, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China. [email protected].\nTaikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China. [email protected]."
] | [
"39762445",
"34282330",
"25680272",
"37548590",
"31802004",
"30814730",
"27808276",
"33188361",
"35245480",
"1161029",
"670176",
"28002401",
"30197295",
"30467178",
"30487554",
"31279659",
"31279658",
"34545078",
"34266951",
"36689652",
"35597784",
"36514940",
"37643007",
"32814042",
"29686425",
"30532012",
"35974096",
"35697799",
"12667688",
"34362929",
"34624505",
"22632970",
"27245739",
"27514700",
"8100776",
"33514910",
"31848460",
"36539498",
"36350986",
"37803832",
"30309857",
"31011207",
"37248395",
"25378643",
"30388456",
"35501486",
"33820778",
"38526325",
"31676230",
"33277233",
"33691090",
"25428505",
"30610226",
"38377992",
"37208329",
"24802416",
"34080411",
"29160310"
] | [] | 9.544352 | 4.553657 |
39762075 | 71 | New developments in immunotherapy for SCLC. | Small cell lung cancer (SCLC) is an aggressive form of neuroendocrine neoplasm known for its striking initial response to treatment, followed by fast relapse and refractoriness in response to additional lines of therapy. New advances in immunotherapy are paving the way for more effective treatment strategies and have promising results with early clinical trial data. While SCLC rarely harbors actionable mutations, the receptor DLL3 is extensively present in SCLC, making it a potential target for immunotherapy. Three emerging therapeutic options include bispecific T cell engagers targeting DLL3, chimeric antigen receptor T cells (CAR-T cells), and antibody-drug conjugates. Several phase II and phase III clinical trials for bispecific T cell engagers show promise. Additionally, the first CAR-T cell trials in humans for SCLC are currently underway. | [
0.0048174867406487465,
0.006379592232406139,
0.059145379811525345,
0.03343622013926506,
-0.005577671807259321,
-0.008215961046516895,
0.006904269102960825,
0.003392512211576104,
-0.00513646611943841,
0.005577671807259321,
-0.013939707539975643,
-0.06830337643623352,
-0.025065239518880844,
0.0308366846293211,
-0.014822118915617466,
-0.04130636900663376,
0.03744284063577652,
-0.04381050914525986,
0.029238805174827576,
0.010100027546286583,
0.025446822866797447,
0.012306055054068565,
-0.007542228326201439,
-0.006594232749193907,
-0.03532028570771217,
-0.011191116645932198,
0.009032787755131721,
-0.017028145492076874,
-0.028809523209929466,
0.007232191972434521,
0.004099037032574415,
-0.023169249296188354,
-0.014631327241659164,
0.018983758985996246,
-0.02883337251842022,
0.040495507419109344,
0.009551501832902431,
0.0340801402926445,
-0.047101665288209915,
-0.015430266968905926,
-0.013665445148944855,
-0.019269946962594986,
0.005395823623985052,
0.050893645733594894,
-0.03379395231604576,
-0.06091020256280899,
0.004939712584018707,
-0.058859191834926605,
-0.01983039639890194,
-0.003127192845568061,
-0.03179064020514488,
-0.0026159309782087803,
-0.009259352460503578,
0.08576080203056335,
-0.06339049339294434,
0.03620269522070885,
-0.016908900812268257,
0.010141762904822826,
0.01391585823148489,
-0.021809859201312065,
0.018315989524126053,
-0.019091079011559486,
0.03140905871987343,
0.012401450425386429,
-0.027163947001099586,
-0.013188465498387814,
-0.026997003704309464,
0.005172239616513252,
0.02058163844048977,
0.0034431912936270237,
0.032315317541360855,
-0.030025819316506386,
-0.0032971163745969534,
0.026376930996775627,
0.026591572910547256,
0.014011254534125328,
0.02307385392487049,
0.023014230653643608,
-0.004626695066690445,
0.0018259347416460514,
0.007989396341145039,
-0.008800259791314602,
0.00611725402995944,
-0.018745269626379013,
-0.02382509410381317,
0.00036239216569811106,
0.001206607441417873,
0.02919110655784607,
-0.06806488335132599,
-0.01868564821779728,
-0.04304734244942665,
-0.006141102872788906,
-0.028523337095975876,
0.01775553822517395,
-0.029238805174827576,
0.0238608680665493,
0.028332544490695,
-0.04605231061577797,
0.02194102853536606,
0.03522488847374916,
0.0157880000770092,
0.026925457641482353,
0.005005297251045704,
-0.05113213509321213,
0.024158980697393417,
0.018160970881581306,
-0.03396089747548103,
-0.007363361306488514,
0.07397942245006561,
-0.04276115447282791,
0.023050004616379738,
0.005202050786465406,
-0.015668755397200584,
0.027712471783161163,
-0.011739642359316349,
-0.04550378397107124,
-0.023061929270625114,
0.0014510591281577945,
0.018196744844317436,
0.04698241874575615,
-0.005202050786465406,
0.05947926640510559,
0.04619540274143219,
-0.027998659759759903,
0.007977471686899662,
-0.031170569360256195,
0.1033136248588562,
-0.07808144390583038,
-0.016885051503777504,
-0.03534413501620293,
0.005750576499849558,
-0.034819457679986954,
0.006838684435933828,
-0.04268961027264595,
-0.05552034080028534,
-0.015322946012020111,
-0.03958924487233162,
-0.01455978024750948,
-0.04104403406381607,
-0.0009002976003102958,
-0.008269621059298515,
0.008740637451410294,
-0.01639614813029766,
0.005231861956417561,
-0.024659808725118637,
-0.04648159071803093,
-0.013319634832441807,
-0.008901618421077728,
-0.03653658181428909,
0.046100009232759476,
-0.033245429396629333,
0.08075252175331116,
0.059860847890377045,
0.022084122523665428,
-0.04936731234192848,
-0.010678364895284176,
-0.013260012492537498,
0.053755518049001694,
-0.00452831806614995,
-0.05213379114866257,
-0.024850599467754364,
0.01589532010257244,
-0.018268290907144547,
-0.02336004003882408,
0.013581973500549793,
-0.006469026207923889,
0.01370121818035841,
0.022549176588654518,
-0.027927113696932793,
-0.008204036392271519,
0.006844646763056517,
-0.027569379657506943,
-0.030097367241978645,
-0.0269016083329916,
-0.04655313864350319,
-0.013176541775465012,
0.044883713126182556,
0.013474653474986553,
-0.009128183126449585,
-0.04276115447282791,
-0.002878269413486123,
0.028642581775784492,
0.02826099842786789,
-0.009336861781775951,
0.017528973519802094,
0.03198143467307091,
-0.03896917402744293,
0.04144946485757828,
-0.027593227103352547,
-0.04109172895550728,
-0.003631001804023981,
-0.006701553240418434,
0.047530945390462875,
0.005395823623985052,
-0.010380253195762634,
0.023443512618541718,
0.05819142237305641,
0.04116327688097954,
-0.0106664402410388,
0.002553327474743128,
0.01929379627108574,
-0.002888703253120184,
-0.04183104634284973,
-0.009784028865396976,
0.018065575510263443,
-0.015191777609288692,
-0.01207352802157402,
0.012174885720014572,
0.017886707559227943,
0.023348115384578705,
0.021058617159724236,
0.01182311400771141,
0.01807750016450882,
0.003791982075199485,
-0.04648159071803093,
-0.026162290945649147,
0.03198143467307091,
-0.012830731458961964,
0.04872339218854904,
0.01721893809735775,
0.03486715629696846,
0.0333646722137928,
-0.0015442190924659371,
0.03498639911413193,
0.007601850666105747,
-0.005300427787005901,
0.03615500032901764,
-0.021428275853395462,
0.023443512618541718,
-0.04984429106116295,
-0.009157994762063026,
0.030622044578194618,
0.0369420126080513,
-0.002685987390577793,
-0.04047165811061859,
0.0014637289568781853,
-0.013570048846304417,
0.0021657822653651237,
0.06138718128204346,
-0.03355546295642853,
0.00873467605561018,
0.021809859201312065,
0.00667174207046628,
0.011191116645932198,
0.009354747831821442,
-0.015919169411063194,
0.0106664402410388,
-0.035964205861091614,
-0.010088102892041206,
0.02597150020301342,
-0.011906584724783897,
0.03133751079440117,
-0.00018725146946962923,
-0.025733010843396187,
0.021786009892821312,
0.027354737743735313,
0.010952627286314964,
-0.051895301789045334,
0.006486912723630667,
-0.02854718640446663,
-0.00611725402995944,
-0.02058163844048977,
-0.0021061599254608154,
-0.03040740266442299,
-0.04359586909413338,
-0.029596539214253426,
0.017016220837831497,
0.0021911216899752617,
0.018697571009397507,
-0.018804892897605896,
-0.00631400803104043,
0.010684327222406864,
0.005798274651169777,
-0.021988725289702415,
-0.02625768631696701,
-0.04435903578996658,
0.007953622378408909,
0.0011738152243196964,
0.00911029614508152,
0.02818945236504078,
-0.05265846848487854,
-0.030598195269703865,
-0.00014719269529450685,
-0.008353092707693577,
-0.04433518648147583,
-0.025637615472078323,
0.00047064400860108435,
-0.04452597722411156,
-0.03458096832036972,
-0.02668696828186512,
-0.014297441579401493,
-0.03384165093302727,
-0.033603161573410034,
0.0018855570815503597,
-0.06582308560609818,
-0.0009330899338237941,
-0.015943018719553947,
-0.010052329860627651,
-0.030645892024040222,
0.07860612124204636,
-0.019770774990320206,
0.022239139303565025,
-0.008722751401364803,
-0.002098707016557455,
0.017159314826130867,
0.02226298861205578,
-0.018208669498562813,
-0.008520035073161125,
0.030145063996315002,
0.00336270104162395,
0.015907244756817818,
0.03489100560545921,
0.03901687264442444,
-0.0026874777395278215,
0.011423643678426743,
-0.015430266968905926,
0.018387535586953163,
-0.015132155269384384,
0.022227216511964798,
-0.06110099330544472,
-0.03248226270079613,
0.01121496595442295,
-0.012914203107357025,
0.010797609575092793,
-0.008991051465272903,
0.009509766474366188,
0.003863528836518526,
-0.003030306426808238,
0.0365842804312706,
-0.05013047903776169,
0.010893004946410656,
0.01886451430618763,
0.049176521599292755,
-0.04595691338181496,
0.006653855089098215,
-0.035463377833366394,
0.0015203701332211494,
-0.05408940464258194,
0.02454056404531002,
0.03105132468044758,
-0.03787212446331978,
0.01441668625921011,
-0.048604145646095276,
0.031170569360256195,
0.03140905871987343,
0.004659487400203943,
-0.015704529359936714,
0.015883397310972214,
0.06591848284006119,
0.0509413443505764,
0.021845633164048195,
0.007154683116823435,
-0.010463723912835121,
-0.024779053404927254,
-0.007178531959652901,
0.028642581775784492,
-0.031814489513635635,
-0.050607457756996155,
0.06191185861825943,
0.01864987425506115,
0.004841335583478212,
-0.008830071426928043,
-0.02411128208041191,
0.06606157124042511,
0.04371511563658714,
0.047387849539518356,
-0.028165603056550026,
-0.010976476594805717,
-0.01309307012706995,
-0.014845967292785645,
0.011244776658713818,
-0.01430936623364687,
0.018196744844317436,
-0.0032881731167435646,
-0.017528973519802094,
0.03751438856124878,
0.02393241599202156,
0.040280867367982864,
0.013677368871867657,
0.027092400938272476,
0.034247081726789474,
0.0108572319149971,
-0.03710895776748657,
-0.01384431216865778,
-0.037275899201631546,
0.009652859531342983,
-0.0037055297289043665,
-0.021845633164048195,
-0.04776943475008011,
0.023980112746357918,
0.014679024927318096,
-0.007524341810494661,
0.04869954288005829,
0.006624043919146061,
-0.01370121818035841,
0.07264388352632523,
-0.00037599349161610007,
0.03772902861237526,
0.028571033850312233,
-0.011608473025262356,
0.015871472656726837,
-0.0017215956468135118,
0.008603506721556187,
-0.07369323819875717,
0.004760845564305782,
-0.03319773077964783,
0.00041623858851380646,
0.003791982075199485,
0.01929379627108574,
-0.017839010804891586,
-0.01355812419205904,
0.02661542035639286,
0.04082939028739929,
0.0012244941899552941,
0.005354087799787521,
-0.02990657463669777,
-0.048461053520441055,
0.028332544490695,
0.035248737782239914,
0.07297776639461517,
0.05909768119454384,
-0.037848275154829025,
0.028952617198228836,
-0.030884381383657455,
0.04402514919638634,
0.02022390440106392,
0.06148257851600647,
-0.015632983297109604,
0.005968198180198669,
-0.02740243636071682,
0.011441530659794807,
0.06820797920227051,
0.006135141011327505,
-0.01639614813029766,
-0.010135801509022713,
0.04822256416082382,
-0.04175950214266777,
-0.01678965613245964,
-0.02740243636071682,
0.018101347610354424,
-0.0067611755803227425,
0.0580960288643837,
-0.015191777609288692,
-0.003487908048555255,
0.0294057484716177,
-0.00589367002248764,
-0.005810198839753866,
0.0014205026673153043,
-0.015835698693990707,
0.010988401249051094,
-0.024373620748519897,
-0.06153027340769768,
-0.009897311218082905,
0.006153027527034283,
-0.02661542035639286,
-0.04268961027264595,
0.039136115461587906,
-0.0810864120721817,
0.0021165937650948763,
0.007935736328363419,
0.03803906589746475,
-0.0351533442735672,
-0.01922224834561348,
-0.03780057653784752,
-0.03939845412969589,
0.03567802160978317,
0.050178177654743195,
-0.009575351141393185,
0.015573360025882721,
0.008615431375801563,
0.003991717007011175,
-0.03362701088190079,
-0.04044780880212784,
0.03644118458032608,
0.010529308579862118,
0.07235769182443619,
0.021595219150185585,
-0.025780707597732544,
0.033889349550008774,
-0.005202050786465406,
0.01309307012706995,
0.04457367584109306,
-0.024922145530581474,
-0.029453445225954056,
0.04025701805949211,
0.0269016083329916,
-0.016694260761141777,
-0.008186150342226028,
-0.01661079004406929,
0.055854227393865585,
0.02318117395043373,
-0.017373954877257347,
0.040924787521362305,
-0.010505459271371365,
-0.03582111373543739,
-0.040423959493637085,
-0.013713142834603786,
-0.028714127838611603,
-0.004471676889806986,
-0.0002819019719026983,
0.013176541775465012,
0.019067229703068733,
-0.011477304622530937,
-0.003654850646853447,
0.0362265445291996,
0.011775416322052479,
0.004760845564305782,
0.0344378761947155,
-0.008215961046516895,
-0.019806547090411186,
-0.0034700213000178337,
0.017493199557065964,
0.026424629613757133,
-0.016098037362098694,
-0.03186218813061714,
-0.03648888319730759,
-0.012437224388122559,
-0.006373630370944738,
0.008257696405053139,
0.007101023104041815,
-0.0001299581053899601,
0.0032643242739140987,
0.002375951036810875,
-0.021678689867258072,
0.025136787444353104,
-0.0033567389473319054,
-0.03140905871987343,
-0.011990056373178959,
-0.035534925758838654,
-0.033460069447755814,
-0.0014264649944379926,
-0.05790523439645767,
0.006743289064615965,
0.03620269522070885,
-0.036631979048252106,
0.0034491533879190683,
-0.029000315815210342,
0.010082140564918518,
-0.0362265445291996,
-0.014953287318348885,
-0.0011611453955993056,
0.009545539505779743,
0.019949641078710556,
0.0038575667422264814,
-0.007965547032654285,
0.03248226270079613,
-0.004325602203607559,
-0.00250115804374218,
0.02194102853536606,
-0.01298575010150671,
0.046529289335012436,
-0.05241997912526131,
0.021774085238575935,
-0.010547195561230183,
0.009462068788707256,
-0.0007493785233236849,
-0.007142758462578058,
0.0010955608449876308,
-0.016408072784543037,
-0.008275583386421204,
-0.014965211972594261,
-0.011352097615599632,
0.0014562761643901467,
-0.03162369877099991,
0.004409073386341333,
-0.016515392810106277,
0.007142758462578058,
-0.009867500513792038,
-0.02711624838411808,
0.03071743994951248,
-0.008347130380570889,
-0.000472879852168262,
-0.006093405187129974,
-0.02240608260035515,
0.027855565771460533,
-0.013176541775465012,
-0.011739642359316349,
0.024123206734657288,
-0.022441856563091278,
0.0073752859607338905,
-0.025160634890198708,
-0.03136136010289192,
0.0007661473355256021,
0.01725471019744873,
-0.011900623328983784,
0.0168612040579319,
-0.04970119893550873,
-0.02357468008995056,
0.003347795456647873,
-0.013116919435560703,
0.02101091854274273,
0.0008883731788955629,
-0.010207347571849823,
-0.002056971425190568,
-0.041354067623615265,
0.011477304622530937,
0.028237149119377136,
-0.03305463492870331,
-0.03947000205516815,
0.0036190771497786045,
-0.0008309866534546018,
0.014857891947031021,
-0.010374290868639946,
-0.03982773795723915,
-0.030168913304805756,
0.0276170764118433,
0.01420204620808363,
-0.030955929309129715,
0.027569379657506943,
0.03484330698847771,
0.014321290887892246,
0.026782363653182983,
-0.0011551831848919392,
-0.012210658751428127,
0.043858207762241364,
0.007476643659174442,
-0.016229206696152687,
-0.0035505115520209074,
0.0301212165504694,
-0.01832791417837143,
-0.05222918838262558,
-0.00636766804382205,
0.008704864419996738,
0.02597150020301342,
0.022418007254600525,
-0.05895458906888962,
-0.05222918838262558,
-0.031170569360256195,
-0.002361045451834798,
0.002572704805061221,
0.002544384216889739,
0.01182311400771141,
-0.0013511917786672711,
0.009873462840914726,
-0.004981447942554951,
-0.005670086480677128,
0.04075784608721733,
0.015394493006169796,
0.005532954819500446,
0.021094391122460365,
-0.015656830742955208,
0.0434289276599884,
-0.0003672364691738039,
-0.025709161534905434,
0.0021076505072414875,
0.010678364895284176,
0.007667435333132744,
-0.051179833710193634,
0.04352432116866112,
-0.0157880000770092,
-0.010893004946410656,
-0.02582840621471405,
0.018554478883743286,
0.013689293526113033,
-0.00136386149097234,
0.02251340262591839,
0.0005891434266231954,
0.017123540863394737,
0.04059090092778206,
0.043238136917352676,
-0.05222918838262558,
-0.0011902113910764456,
0.0007288833730854094,
-0.013438879512250423,
-0.016348451375961304,
-0.0005682756309397519,
0.02237030863761902,
0.004045377019792795,
0.005291484296321869,
-0.01298575010150671,
0.05542494356632233,
0.029668085277080536,
0.030788986012339592,
0.020021189004182816,
0.0063557433895766735,
0.02232261188328266,
0.008865844458341599,
0.027426285669207573,
-0.02876182645559311,
0.0006603176589123905,
-0.000583926506806165,
0.015346795320510864,
-0.025804556906223297,
-0.039207663387060165,
-0.003112287260591984,
-0.006749250926077366,
-0.007935736328363419,
0.01000463217496872,
-0.0024266301188617945,
-0.0013914367882534862,
0.0159668680280447,
-0.03832525387406349,
0.006701553240418434,
-0.02525603212416172,
-0.0011909566819667816,
0.013367333449423313,
0.03973234072327614,
-0.013057297095656395,
-0.02511293813586235,
-0.009581313468515873,
0.017839010804891586,
-0.008585619740188122,
0.011548850685358047,
-0.03362701088190079,
0.02421860210597515,
-0.0019123872043564916,
-0.022835364565253258,
-0.010052329860627651,
0.030168913304805756,
0.010511421598494053,
-0.0036339827347546816,
-0.02400396205484867,
-0.02876182645559311,
-0.008561770431697369,
-0.020772429183125496,
-0.007208343129605055,
-0.031027475371956825,
0.005863858852535486,
0.005210994277149439,
0.0038993023335933685,
0.0032285507768392563,
-0.02482675015926361,
-0.040352411568164825,
-0.0022701213601976633,
0.0008973164949566126,
0.030025819316506386,
-0.03918381407856941,
0.04858030006289482,
-0.014583629556000233,
0.015871472656726837,
0.005783368833363056,
-0.013474653474986553,
-0.025446822866797447,
-0.03148060664534569,
-0.03522488847374916,
0.03186218813061714,
-0.050607457756996155,
-0.00661808205768466,
-0.018626024946570396,
-0.011936396360397339,
0.05637890473008156,
-0.04316658899188042,
-0.03887377679347992,
-0.00019712642824742943,
-0.008013244718313217,
0.029024165123701096,
-0.003532624803483486,
0.014440535567700863,
-0.01983039639890194,
-0.030073517933487892,
0.008215961046516895,
0.008615431375801563,
-0.0024966862984001637,
-0.031146720051765442,
-0.008007283322513103,
-0.01541834231466055,
-0.0014361535431817174,
-0.006066575180739164,
0.042069535702466965,
-0.02997812256217003,
-0.021917179226875305,
-0.02718779630959034,
0.005473332479596138,
0.012413375079631805,
0.007262003608047962,
0.012079490348696709,
-0.012449149042367935,
0.0014279554598033428,
-0.01116130594164133,
0.016050338745117188,
-0.02826099842786789,
-0.033603161573410034,
0.0054822759702801704,
-0.016741959378123283,
0.0014726723311468959,
0.01743357814848423,
-0.028642581775784492,
0.007816491648554802,
-0.0031510416883975267,
-0.009521691128611565,
-0.0007825434440746903,
-0.003222588449716568,
0.002246272284537554,
-0.024922145530581474,
-0.0006685156840831041,
0.015811849385499954,
0.005175220780074596,
0.04722090810537338,
-0.01330771017819643,
0.002836533822119236,
-0.01850678026676178,
0.041997991502285004,
-0.01750512421131134,
0.00034711393527686596,
-0.010076179169118404,
0.021952953189611435,
0.02396818809211254,
-0.10293204337358475,
-0.023419663310050964,
0.017087768763303757,
-0.007047363091260195,
-0.03670352324843407,
-0.007488568313419819,
-0.049176521599292755,
0.015215625986456871,
0.009157994762063026,
-0.015346795320510864,
0.016443846747279167,
-0.03019276261329651,
-0.0016783694736659527,
0.001403361326083541,
-0.02561376616358757,
-0.009533614851534367,
-0.01943688839673996,
-0.03937460482120514,
-0.02604304626584053,
0.018912212923169136,
0.006892344914376736,
0.011554813012480736,
-0.029882727190852165,
0.05079824849963188,
-0.013796613551676273,
0.0060755182057619095,
-0.030168913304805756,
0.013498501852154732,
-0.04009007290005684,
-0.014130499213933945,
0.029071861878037453,
-0.014285516925156116,
-0.05256307125091553,
0.011924471706151962,
0.00828750804066658,
-0.040781695395708084,
0.006206687539815903,
-0.016980448737740517,
0.008728713728487492,
0.014643251895904541,
0.01445246022194624,
0.010314668528735638,
0.028737977147102356,
0.01875719428062439,
-0.02504139021039009,
-0.02160714380443096,
-0.06348589062690735,
0.006000990513712168,
0.016300752758979797,
-0.016276903450489044,
0.047817133367061615,
-0.030001971870660782,
-0.013462728820741177,
-0.008746599778532982,
-0.0037353408988565207,
-0.003651869483292103,
-0.002292479621246457,
0.019997339695692062,
0.05065515637397766,
0.013069220818579197,
-0.03162369877099991,
0.041210975497961044,
-0.01284265611320734,
0.0002610341471154243,
-0.02511293813586235,
-0.011501152999699116,
-0.037061259150505066,
-0.016992371529340744,
-0.01782708615064621,
0.012854580767452717,
0.02129710651934147,
-0.02711624838411808,
-0.032887693494558334,
0.052610769867897034,
0.026424629613757133,
-0.007852264679968357,
0.00012325058924034238,
-0.00784034002572298,
0.0120198680087924,
0.036178845912218094,
-0.012389526702463627,
0.020283525809645653,
-0.010863194242119789,
-0.00043039891170337796,
0.005079824943095446,
-0.02919110655784607,
0.03183833882212639,
0.01854255422949791,
0.006946004927158356,
-0.03396089747548103,
0.007524341810494661,
-0.0021344805136322975,
0.013176541775465012,
0.024266300722956657,
-0.024659808725118637,
0.006066575180739164,
-0.005962235853075981,
-0.03560647368431091,
-0.012401450425386429,
-0.005512087140232325,
0.049176521599292755,
0.001042646006681025,
-0.007089098449796438,
0.00045238464372232556,
-0.00667174207046628,
-0.014333215542137623,
0.015513737685978413,
0.00794766005128622,
-0.0168612040579319,
-0.015907244756817818,
0.02051009237766266,
-0.029524993151426315,
0.02654387429356575,
0.020629337057471275,
0.001099287299439311,
0.0134508041664958,
0.03744284063577652,
-0.018709495663642883,
0.02396818809211254,
-0.006102348677814007,
0.061291784048080444,
-0.007238154299557209,
-0.0213328804820776,
-0.0035952283069491386,
-0.03608345240354538,
0.020319299772381783,
0.028714127838611603,
-0.0002224659256171435,
-0.02328849397599697,
-0.004495525732636452,
0.012139112688601017,
-0.0013511917786672711,
0.014738647267222404,
-0.010475648567080498,
-0.008567732758820057,
0.03164754807949066,
0.029524993151426315,
0.045098353177309036,
0.014070876874029636,
0.034914854913949966,
0.029668085277080536,
-0.03069359064102173,
-0.007935736328363419,
0.01097051426768303,
0.005625369492918253,
-0.003985754679888487,
-0.01925802230834961,
0.003529643639922142,
-0.02226298861205578,
0.028070207685232162,
0.010386214591562748,
0.00288572208955884,
-0.0016202375991269946,
0.021487899124622345,
0.010565082542598248,
0.02282343991100788,
0.018745269626379013,
-0.02228683792054653,
-0.03377010300755501,
0.004403111059218645,
-0.017743613570928574,
0.04364356771111488,
-0.019353417679667473,
-0.023622378706932068,
-0.02876182645559311,
0.014404761604964733,
-0.008770449087023735,
-0.018590250983834267,
0.015084456652402878,
0.02068895846605301,
0.016336526721715927,
-0.07273928076028824,
0.03598805516958237,
-0.030979778617620468,
-0.007363361306488514,
0.016193432733416557,
0.004650543909519911,
0.021094391122460365,
-0.0017901613609865308,
0.027569379657506943,
-0.012079490348696709,
0.014953287318348885,
-0.001182013307698071,
0.05175220966339111,
0.036178845912218094,
-0.006802911404520273,
-0.018482930958271027,
-0.0159668680280447,
0.018494855612516403,
0.01993771642446518,
-0.0045372615568339825,
-0.0006297611980699003,
0.01141171995550394,
-0.008555809035897255,
0.03772902861237526,
-0.014655175618827343,
-0.04187874495983124,
0.007882076315581799,
0.0008682506158947945,
-0.004978467244654894,
-0.004689298570156097,
0.07665050774812698,
0.059431567788124084,
-0.007339512463659048,
-0.027378587052226067,
0.023956263437867165,
0.05432789400219917,
-0.053850915282964706,
-0.029858877882361412,
0.03212452679872513,
-0.0031182493548840284,
0.006218612194061279,
-0.01965153031051159,
0.025065239518880844,
0.005485257133841515,
-0.00925339013338089,
0.019341493025422096,
-0.010207347571849823,
-0.04137791693210602,
-0.015811849385499954,
-0.001986915012821555,
-0.04137791693210602,
-0.0017320294864475727,
-0.008997013792395592,
-0.030216611921787262,
0.04037626087665558,
0.0312182679772377,
0.020450469106435776,
-0.01818482019007206,
0.01384431216865778,
0.014011254534125328,
0.0006837939145043492,
0.01872142031788826,
0.020140433683991432,
-0.017982102930545807,
-0.02022390440106392,
0.013975481502711773,
-0.035248737782239914,
0.0294057484716177,
0.021356729790568352,
0.06091020256280899,
0.015442190691828728,
-0.015907244756817818,
-0.028308697044849396,
-0.00894931610673666,
0.06486912816762924,
0.036631979048252106,
-0.0523722805082798,
-0.03257765620946884,
-0.003237494034692645,
0.01538256835192442,
-0.010487573221325874,
0.01320039015263319,
0.043452776968479156,
0.022835364565253258,
0.022346461191773415,
-0.007738982327282429,
-0.016479620710015297,
0.04104403406381607,
-0.015466040000319481,
-0.004781713243573904,
0.013295786455273628,
-0.0055091059766709805,
0.00936071015894413,
0.011352097615599632,
0.017016220837831497,
-0.017051994800567627,
-0.012121225707232952,
0.009008938446640968,
0.012133150361478329,
-0.013677368871867657,
0.004707185085862875,
-0.0067611755803227425,
-0.006606157403439283,
-0.0026442515663802624,
0.008293470367789268,
0.018017876893281937,
-0.01391585823148489,
0.012651864439249039,
-0.014476308599114418,
0.006415365729480982,
-0.01754089817404747,
0.0067075155675411224,
0.03248226270079613,
0.04359586909413338,
-0.015287172980606556,
-0.01897183433175087,
-0.0077866800129413605,
0.025947650894522667,
-0.06033782660961151,
-0.024922145530581474,
0.019711151719093323,
-0.028213299810886383,
-0.018673723563551903,
-0.03923151269555092,
-0.042355723679065704,
0.019269946962594986,
0.0042063575237989426,
0.0072739277966320515,
-0.020092735067009926,
0.014643251895904541,
0.031456757336854935,
-0.00016433412383776158,
0.012413375079631805,
0.009384559467434883,
-0.02446901611983776,
-0.013617746531963348,
-0.01936534233391285,
0.013820462860167027,
-0.021058617159724236,
-0.040924787521362305,
0.005696916487067938,
-0.008847958408296108,
0.0455753318965435,
0.001571049215272069,
0.015561435371637344,
-0.003030306426808238,
0.010797609575092793,
0.001723086228594184,
0.009462068788707256,
0.009301087819039822,
-0.01872142031788826,
0.002584629226475954,
-0.0037860197480767965,
-0.04841335490345955,
0.006266309879720211,
-0.008305395022034645,
-0.0032822107896208763,
-0.0013094560708850622,
0.009384559467434883,
0.019782699644565582,
0.001084381714463234,
0.012109301052987576,
0.0008004301926121116,
-0.012926127761602402,
0.012043716385960579,
0.01323616411536932,
-0.002393837785348296,
-0.006224574521183968,
-0.011691944673657417,
-0.017302408814430237,
-0.025494521483778954,
0.005222918465733528,
0.0006331149488687515,
0.0247552040964365,
0.00753030413761735,
0.013248087838292122,
-0.0015874452656134963,
0.02876182645559311,
-0.014869816601276398,
0.05661739408969879,
-0.013975481502711773,
-0.040996335446834564,
0.00986153818666935,
0.018566403537988663,
0.01986617036163807,
-0.016133811324834824,
0.01850678026676178,
0.0067075155675411224,
0.01227028202265501,
-0.0010515893809497356,
0.06940042972564697,
0.01603841409087181,
-0.011292475275695324,
0.01664656214416027,
0.001653029932640493,
0.002097216434776783,
-0.007303738966584206,
0.0022716119419783354,
-0.021893329918384552,
-0.003213645191863179,
0.04672008007764816,
-0.019639605656266212,
-0.0069161937572062016,
-0.004435903392732143,
0.01593109406530857,
0.04030471667647362,
0.02140442654490471,
-0.010767797939479351,
0.03291154280304909,
-0.01355812419205904,
-0.013224239461123943,
0.0014279554598033428,
-0.001042646006681025,
-0.015334870666265488,
-0.049462709575891495,
-0.03427093103528023,
-0.013736991211771965,
0.006641930900514126,
0.019782699644565582,
-0.017016220837831497,
-0.029358049854636192,
0.0063557433895766735,
0.03329312428832054,
-0.019091079011559486,
-0.038706835359334946,
0.005047032609581947,
-0.0028678355738520622,
0.014893664978444576,
0.04309504106640816,
-0.0365842804312706,
-0.008347130380570889,
0.0019123872043564916,
-0.016276903450489044,
-0.011364021338522434,
0.01643192209303379,
0.0022060272749513388,
0.0016768788918852806,
-0.011089758947491646,
-0.0042779045179486275,
-0.041997991502285004,
-0.006498837377876043,
-0.0470062680542469,
0.029739633202552795,
0.004423979204148054,
-0.009736331179738045,
-0.0004069225979037583,
-0.0072739277966320515,
-0.04047165811061859,
0.023240795359015465,
-0.023205021396279335,
0.002987080253660679,
0.0007698737317696214,
0.012902278453111649,
-0.006325932219624519,
0.006278234533965588,
-0.006445176899433136,
-0.0018810854526236653,
-0.0365842804312706,
-0.000009123851668846328,
0.022024499252438545,
0.02461211010813713,
0.01940111629664898,
0.010940702632069588,
0.006349781062453985,
-0.0011469851015135646,
-0.006946004927158356,
-0.004716128576546907,
0.0007721095462329686,
0.027712471783161163,
-0.0012811354827135801,
0.017552822828292847,
0.018947985023260117,
-0.0017484256532043219,
0.011763491667807102,
-0.02368200197815895,
-0.023634303361177444,
0.021130165085196495,
0.008692939765751362,
-0.034318629652261734,
0.027497831732034683,
0.004710166249424219,
-0.031027475371956825,
-0.008043056353926659,
-0.02036699838936329,
0.027426285669207573,
-0.028213299810886383,
-0.023383889347314835,
0.011751567013561726,
0.00241619604639709,
-0.011250738985836506,
-0.01607418805360794,
-0.0021762161049991846,
-0.034962549805641174,
0.006790986750274897,
0.010815495625138283,
-0.013617746531963348,
0.0050768437795341015,
0.004045377019792795,
0.010380253195762634,
-0.00875256210565567,
-0.017958255484700203,
0.007130834273993969,
-0.02421860210597515,
0.00611725402995944,
-0.0351533442735672,
0.01836368627846241,
0.03255380690097809,
0.001512917340733111,
-0.0025801577139645815,
-0.02151174657046795,
-0.005127523094415665,
0.014178196899592876,
0.05265846848487854,
-0.002586119808256626,
0.004218281712383032,
-0.00414375402033329,
-0.058143723756074905,
0.055281851440668106,
0.03221992403268814,
0.011501152999699116,
-0.011447492986917496,
-0.017278559505939484,
-0.02154752053320408,
-0.01843523420393467,
0.016384223476052284,
0.009891349822282791,
-0.01771976612508297,
0.013283861801028252,
0.008597544394433498,
0.02482675015926361,
0.003419342217966914,
0.0056372941471636295,
-0.02382509410381317,
0.03205297887325287,
0.018554478883743286,
-0.047674037516117096,
-0.053421635180711746,
-0.0068684956058859825,
0.001264739315956831,
-0.0448598638176918,
-0.00447465805336833,
-0.016193432733416557,
0.021571369841694832,
0.038062915205955505,
0.02468365617096424,
-0.02015235833823681,
0.046314649283885956,
0.01409472618252039,
0.006606157403439283,
-0.008567732758820057,
0.028571033850312233,
0.021678689867258072,
-0.030932080000638962,
-0.010839344933629036,
-0.013140767812728882,
-0.030884381383657455,
0.02382509410381317,
-0.014535930939018726,
0.005646237637847662,
0.01890028826892376,
-0.020629337057471275,
0.01993771642446518,
-0.005673067644238472,
-0.03143290802836418,
0.0017201050650328398,
-0.005541898310184479,
-0.010571043938398361,
-0.02104669250547886,
0.038921475410461426,
-0.004948655609041452,
0.01284265611320734,
-0.01947266235947609,
-0.007768793497234583,
0.0040245093405246735,
0.015096381306648254,
0.03966079279780388,
-0.009742293506860733,
0.008675053715705872,
0.025804556906223297,
-0.0009390521445311606,
-0.0087883360683918,
0.022346461191773415,
0.007345474790781736,
-0.026305384933948517,
-0.009134145453572273,
-0.000012786201295966748,
-0.0053332201205194,
-0.003821793245151639,
-0.018852589651942253,
0.01607418805360794,
0.02568531222641468,
-0.005962235853075981,
0.046314649283885956,
0.0014555308734998107,
0.0018005952006205916,
-0.011751567013561726,
0.004945674911141396,
-0.02518448419868946,
-0.00447465805336833,
0.005926462356001139,
-0.039636943489313126,
0.007798604667186737,
0.017123540863394737,
-0.019389191642403603,
0.023312343284487724,
-0.0017692935653030872,
0.0032673052046447992,
0.0003184206725563854,
-0.02414705604314804,
0.005142428446561098,
-0.004948655609041452,
0.011697907000780106,
-0.01922224834561348,
0.013546200469136238,
-0.03198143467307091,
-0.013546200469136238,
-0.0023222907911986113,
0.0057356711477041245,
-0.049462709575891495,
-0.0055627659894526005,
0.014535930939018726,
0.004513412714004517,
0.026806212961673737,
0.013713142834603786,
0.026305384933948517,
-0.00782245397567749,
0.028284847736358643,
-0.021630991250276566,
-0.011006287299096584,
0.015144078992307186,
0.057142067700624466,
0.0007389446254819632,
0.008031131699681282,
0.017528973519802094,
0.0024251395370811224,
-0.013403106480836868,
-0.025876104831695557,
-0.00782245397567749,
-0.009432257153093815,
-0.010046367533504963,
0.011125531978905201,
0.0037055297289043665,
0.008311357349157333,
-0.03582111373543739,
0.009837688878178596,
-0.039780039340257645,
-0.00753030413761735,
0.03534413501620293,
0.031742945313453674,
-0.0027918170671910048,
0.0401616208255291,
-0.026066895574331284,
0.0020375940948724747,
-0.03522488847374916,
0.004400129895657301,
-0.057142067700624466,
0.003923151176422834,
0.024087432771921158,
0.023550832644104958,
-0.043142739683389664,
0.03830140456557274,
0.0011335700983181596,
-0.03558262437582016,
-0.005673067644238472,
-0.00227757403627038,
-0.005819142330437899,
0.022310687229037285,
-0.038492195308208466,
0.004486582707613707,
0.00971844419836998,
0.028427941724658012,
-0.0026666100602597,
-0.0018289159052073956,
-0.03429478034377098,
0.01621728204190731,
-0.027569379657506943,
-0.00971844419836998,
-0.008281545713543892,
0.016730034723877907,
0.0018855570815503597,
0.008025169372558594,
0.004650543909519911,
0.04908112809062004,
0.01203775405883789,
0.011191116645932198,
0.0015382568817585707,
-0.009187805466353893,
-0.05537724867463112,
-0.018637949600815773,
0.005291484296321869,
-0.012544544413685799,
-0.004009603522717953,
0.04490756243467331,
-0.012353752739727497,
-0.0015650868881493807,
0.035248737782239914,
0.009313012473285198,
-0.013295786455273628,
0.011721756309270859,
-0.013116919435560703,
0.003045212011784315,
-0.01011195220053196,
-0.00032307865330949426,
0.06982970982789993,
-0.003967868164181709,
0.0012960410676896572,
0.018017876893281937,
-0.00236253603361547,
-0.011346135288476944,
-0.005458427127450705,
-0.03250611200928688,
0.029071861878037453,
-0.018816817551851273,
0.04691087082028389,
0.031671397387981415,
0.049033429473638535,
0.043786659836769104,
-0.00005049268656875938,
-0.023884717375040054,
0.02826099842786789,
0.017195088788866997,
-0.028356393799185753,
-0.0423080250620842,
-0.011048023588955402,
-0.015036758966743946,
-0.005968198180198669,
0.006558459717780352,
-0.017850933596491814,
-0.006856571417301893,
0.00584001000970602,
0.007238154299557209,
-0.006963891442865133,
-0.016694260761141777,
-0.008251735009253025,
0.011036098934710026,
0.01661079004406929,
-0.010207347571849823,
-0.027998659759759903,
-0.0003964887000620365,
-0.0010173064656555653,
-0.028666431084275246,
-0.014822118915617466,
0.04223648086190224,
0.007810528855770826,
0.011996018700301647,
-0.009921160526573658,
0.001597879221662879,
0.02293075993657112,
-0.012449149042367935,
-0.027712471783161163,
0.008227885700762272,
0.035844963043928146,
-0.010356403887271881,
0.01704007014632225,
0.0351533442735672,
0.041425615549087524,
0.012902278453111649,
-0.010129839181900024,
-0.0007389446254819632,
-0.0028156659100204706,
0.0003446917689871043,
0.015346795320510864,
-0.013605822809040546,
-0.012365677393972874,
0.012568393722176552,
0.003225569613277912,
-0.03679892048239708,
0.020033113658428192
] | 2025-01-07 | 43 | 39762075 | [
"bispecific T cell engagers",
"chimeric antigen receptor T cells",
"Small cell lung cancer",
"early clinical trial data",
"CAR-T cells",
"treatment",
"neuroendocrine neoplasm",
"response",
"fast relapse",
"DLL3",
"actionable mutations",
"additional lines",
"the first CAR-T cell trials",
"immunotherapy",
"New advances",
"SCLC",
"refractoriness",
"more effective treatment strategies",
"its striking initial response",
"results",
"III clinical trials",
"humans",
"therapy",
"Three emerging therapeutic options",
"antibody-drug conjugates",
"first",
"promise",
"an aggressive form",
"the receptor",
"the way"
] | [
"Bispecific T cell engager - BiTE",
"Immunotherapy",
"Lung Cancer"
] | 0 | 10.1136/jitc-2024-009667
10.1016/j.lungcan.2021.04.013
10.1016/S1470-2045(20)30068-1
10.1038/s41572-020-00235-0
10.1016/j.celrep.2016.06.081
10.1016/j.ccell.2020.12.014
10.1016/j.cell.2023.12.004
10.1001/jamaoncol.2023.4025
10.1101/gad.349359.122
10.1053/bbmt.2002.v8.pm12064365
10.1056/NEJMoa1809064
10.1016/S0140-6736(19)32222-6
10.1016/j.cllc.2021.09.003
10.1200/JCO.23.01363
10.1158/2159-8290.CD-20-0913
10.1056/NEJMoa2404873
10.1111/cas.13997
10.1016/j.lungcan.2020.07.026
10.1007/s11523-023-01008-x
10.1016/j.jtocrr.2024.100712
10.1038/s41416-023-02427-3
10.1158/1078-0432.CCR-21-1533
10.1136/jitc-2022-005187
10.3389/fonc.2020.01000
10.1136/jitc-2021-003897
10.1182/blood-2010-09-306449
10.1186/s40364-021-00294-9
10.1186/s13045-023-01464-y
10.1056/NEJMoa2307980
10.1200/JCO.22.02823
10.1158/2159-8290.CD-17-0698
10.1016/j.bbmt.2018.12.758
10.1136/jitc-2020-000785
10.1158/2326-6066.CIR-23-0638
10.1158/1078-0432.CCR-19-1133
10.1016/j.jtho.2021.07.012
10.1038/s41571-023-00754-1
10.1158/1078-0432.CCR-22-2293
10.1172/JCI166028
10.1002/JLB.5MA0122-467R
10.1200/JCO.2010.33.3716
10.1038/s41586-022-04585-5
10.1158/0008-5472.CAN-22-2245
10.1038/s41591-023-02612-0
10.3389/fimmu.2023.1118610
10.3389/fimmu.2022.879608 | [
"Dolkar",
"Gates",
"Hao",
"Munker"
] | [
"Hospital Medicine, University of Kentucky, Lexington, Kentucky, USA.",
"Hematology - Oncology, University of Kentucky, Lexington, Kentucky, USA.",
"Medical Oncollogy, University of Kentucky, Lexington, Kentucky, USA.",
"University of Kentucky, Lexington, Kentucky, USA [email protected]."
] | [
"39762075",
"32224306",
"33446664",
"27452466",
"33482121",
"38181741",
"37824137",
"35318269",
"12064365",
"30280641",
"31590988",
"34656433",
"37976444",
"33707236",
"39268857",
"30874360",
"37930513",
"39309421",
"37731022",
"35046060",
"36167468",
"32733795",
"35022195",
"21300981",
"34039409",
"37355629",
"37861218",
"36689692",
"29025771",
"30592986",
"32554616",
"38558120",
"31506387",
"34425994",
"37055515",
"36692420",
"36951942",
"35088475",
"22253462",
"36548402",
"37872225",
"36860862",
"36081506"
] | [] | 7.301825 | 6.355901 |
39762074 | 72 | XCL1-secreting CEA CAR-T cells enhance endogenous CD8 | Therapeutic efficacy of carcinoembryonic antigen (CEA)-specific chimeric antigen receptor (CAR) T cells against colorectal cancer (CRC) remains limited due to the unique characteristics and distinct microenvironments of tumor tissues. We modified CEA-specific CAR-T cells, aiming to stimulate endogenous CD8
In a conventional CEA CAR (reg-CAR), we modified it to express lymphotactin XCL1 and interleukin (IL)-7 genes, constructing a modified 7XCL1-CAR. By generating the CEA-specific 7XCL1-CAR T cells, we assessed their antitumor efficacy against CRC cells with varying levels of CEA expression, both in cell-cultures and in two strains of tumor-bearing syngeneic mice.
Following retroviral transduction, 7XCL1-CAR T cells and reg-CAR T cells exhibited similar positive proportions of CEA-CAR and CD4:CD8 ratios. In co-culture system with CEA-negative CT26 cells, no differences in cytotoxicity were observed between 7XCL1-CAR and reg-CAR T cells. However, in co-culture with CT26.CEA
Treatment with CEA-specific, XCL1-secreting CAR-T cells for CEA-positive tumors promoted the generation of CD8 | [
0.04604463651776314,
0.012994615361094475,
0.059062253683805466,
0.05575035139918327,
-0.041628770530223846,
0.008147508837282658,
0.004545240662992001,
0.011269666254520416,
0.014397574588656425,
-0.014374574646353722,
-0.01003345288336277,
-0.03256703540682793,
-0.029209136962890625,
0.01938842609524727,
0.019779415801167488,
-0.03236004337668419,
0.06545606255531311,
-0.013500601053237915,
0.0069112954661250114,
0.03063509427011013,
0.027576183900237083,
-0.010798180475831032,
0.010240446776151657,
0.020331399515271187,
-0.034682974219322205,
0.005031101405620575,
-0.008544247597455978,
0.020952381193637848,
-0.029278134927153587,
-0.012040143832564354,
0.036476921290159225,
-0.013282107189297676,
-0.030060110613703728,
-0.036200929433107376,
-0.0335560068488121,
0.02504625916481018,
0.04408969730138779,
-0.002784355077892542,
0.015375045128166676,
-0.012718623504042625,
0.027760179713368416,
0.014443572610616684,
0.011833149939775467,
0.05119648575782776,
-0.04512466490268707,
-0.023332810029387474,
-0.02274632640182972,
-0.024954261258244514,
0.005189221352338791,
0.014777062460780144,
-0.025759238749742508,
0.005355966743081808,
-0.012166639789938927,
0.02610422857105732,
-0.051012489944696426,
0.01246563158929348,
-0.03270503133535385,
0.023378808051347733,
-0.011281166225671768,
0.02520725503563881,
-0.011557158082723618,
0.001612827298231423,
0.0018615074222907424,
-0.04733259975910187,
-0.040501803159713745,
-0.0170539952814579,
-0.027645181864500046,
-0.008705242536962032,
0.03279703110456467,
-0.009941455908119678,
0.00037984814844094217,
-0.007768020033836365,
-0.005870576482266188,
0.0385698601603508,
0.06702002137899399,
-0.05055250599980354,
0.029393130913376808,
0.031946055591106415,
0.0030732841696590185,
-0.01582353189587593,
0.03286602720618248,
0.02387329377233982,
0.01486906036734581,
0.0055428361520171165,
0.009044482372701168,
-0.0419277586042881,
0.007791019510477781,
-0.03806387260556221,
-0.012810621410608292,
-0.00039709763950668275,
-0.008274005725979805,
0.019779415801167488,
-0.020193403586745262,
0.024241283535957336,
0.006721551064401865,
0.05349641665816307,
-0.02672521024942398,
-0.05372641235589981,
0.0452856607735157,
0.03114107809960842,
0.0217918548732996,
0.004898854997009039,
-0.02766818180680275,
-0.016111023724079132,
0.05745230242609978,
0.011971145868301392,
-0.07111389935016632,
0.01526004821062088,
0.0005203596083447337,
-0.03925983980298042,
0.10423291474580765,
-0.020940881222486496,
-0.004019130952656269,
0.011971145868301392,
-0.019365428015589714,
-0.04146777465939522,
-0.05299043282866478,
-0.014098582789301872,
0.008210756815969944,
0.05372641235589981,
-0.012500130571424961,
0.053358420729637146,
0.022596832364797592,
-0.05846427008509636,
0.0010680309496819973,
-0.02414928562939167,
0.06688202172517776,
-0.029255134984850883,
-0.030980084091424942,
-0.03571794182062149,
0.04673461616039276,
0.005804453510791063,
0.05036851018667221,
0.029209136962890625,
-0.06725001335144043,
-0.014604568481445312,
-0.005433589220046997,
-0.04293972998857498,
-0.0469646118581295,
0.001068749581463635,
0.00746327918022871,
0.005396215245127678,
-0.04668862000107765,
-0.01995190978050232,
-0.048988550901412964,
-0.036407921463251114,
-0.04682661592960358,
-0.007400031201541424,
0.01711149327456951,
0.05138048157095909,
-0.0036913908552378416,
0.041007786989212036,
0.050506506115198135,
0.00006446098268497735,
-0.007078040856868029,
-0.04935653880238533,
-0.026633212342858315,
0.036200929433107376,
-0.022378338500857353,
-0.05795828625559807,
-0.013822590932250023,
0.001966441748663783,
-0.05170246958732605,
0.005275468807667494,
0.0237582977861166,
-0.025115257129073143,
-0.028818147256970406,
0.045975640416145325,
-0.08298154920339584,
-0.00685954699292779,
-0.021504363045096397,
-0.05202446132898331,
-0.052070461213588715,
-0.010487689636647701,
-0.07801369577646255,
-0.015375045128166676,
0.0298991147428751,
-0.012201138772070408,
-0.018376456573605537,
0.004065129905939102,
-0.03415399044752121,
0.04344571381807327,
-0.018134962767362595,
0.03472897410392761,
0.014271077699959278,
0.02135486900806427,
-0.020768385380506516,
0.015720035880804062,
-0.027185196056962013,
-0.02822016552090645,
0.006721551064401865,
-0.0064110602252185345,
0.08353353291749954,
0.03735089674592018,
-0.035740941762924194,
-0.019917411729693413,
0.039558831602334976,
0.016306517645716667,
-0.017916470766067505,
-0.02856515534222126,
-0.004453243222087622,
0.0033981495071202517,
-0.051518477499485016,
0.03330301493406296,
0.013868589885532856,
-0.0385928601026535,
-0.024954261258244514,
0.04783858358860016,
-0.03758088871836662,
0.008348752744495869,
0.03923683986067772,
-0.014777062460780144,
-0.013063613325357437,
-0.004654487129300833,
-0.03001411259174347,
-0.032061051577329636,
0.012327635660767555,
0.008509748615324497,
0.04829857125878334,
0.03718990087509155,
0.004450368229299784,
-0.0028677277732640505,
0.0173184871673584,
0.015444043092429638,
-0.059062253683805466,
-0.012787621468305588,
-0.006704301573336124,
-0.01754848100244999,
-0.0013123987009748816,
-0.0408007949590683,
-0.013029114343225956,
0.03829386830329895,
0.026058228686451912,
-0.035303954035043716,
-0.02978411875665188,
-0.003694265615195036,
0.01665150746703148,
-0.03040510043501854,
0.04093879088759422,
-0.0051317233592271805,
0.004079504404217005,
0.054922375828027725,
0.023355809971690178,
-0.02801317162811756,
-0.027645181864500046,
0.015168051235377789,
-0.0008445062558166683,
-0.04967853054404259,
-0.02594323270022869,
0.017145993188023567,
0.0025227379519492388,
0.023447806015610695,
0.011102921329438686,
-0.015835031867027283,
0.016065025702118874,
0.03215304762125015,
0.01135016418993473,
-0.02638022042810917,
0.012684124521911144,
-0.044687677174806595,
0.013201609253883362,
0.006278814282268286,
-0.023217814043164253,
-0.04270973801612854,
-0.0030646594241261482,
0.03551094979047775,
0.0018960064044222236,
0.016904499381780624,
0.016927499324083328,
-0.016927499324083328,
0.03270503133535385,
0.016525011509656906,
0.03693690896034241,
-0.014098582789301872,
-0.0352119579911232,
0.0024005540180951357,
-0.00229993206448853,
0.014846060425043106,
-0.008015262894332409,
0.0013339605648070574,
-0.019353928044438362,
0.00832575373351574,
-0.01816946268081665,
0.005991322919726372,
-0.03436098247766495,
-0.023125816136598587,
0.00802676286548376,
-0.0030991584062576294,
-0.005442214198410511,
-0.027921173721551895,
0.052346453070640564,
-0.01022894773632288,
-0.021826354786753654,
-0.04576864466071129,
-0.0749317854642868,
0.03965082764625549,
0.0022165593691170216,
-0.029209136962890625,
-0.028588155284523964,
-0.0015064554754644632,
-0.05147247761487961,
0.019089436158537865,
-0.033625006675720215,
0.015306047163903713,
0.026035230606794357,
-0.008262505754828453,
-0.009412471204996109,
-0.03282003104686737,
0.00907898135483265,
0.04560765251517296,
0.0237582977861166,
0.005614709109067917,
0.0215273629873991,
0.041674766689538956,
0.03679891303181648,
-0.010303695686161518,
0.02146986499428749,
-0.022067846730351448,
0.01744498312473297,
-0.03146306797862053,
-0.050046518445014954,
-0.02426428161561489,
-0.02598923072218895,
-0.003694265615195036,
0.020883383229374886,
-0.00711253983899951,
-0.002081438433378935,
0.015547540038824081,
0.024839265272021294,
-0.008130259811878204,
0.027185196056962013,
-0.03758088871836662,
0.05092049390077591,
-0.023321310058236122,
0.029002143070101738,
-0.030497098341584206,
-0.016686007380485535,
-0.05611833930015564,
0.03259003534913063,
0.012385133653879166,
0.01168365404009819,
0.018870942294597626,
-0.018847942352294922,
0.052070461213588715,
0.029692120850086212,
0.025575242936611176,
0.013604097999632359,
0.02638022042810917,
0.022999320179224014,
0.04004181548953056,
-0.024126285687088966,
0.0007489153649657965,
-0.008751241490244865,
-0.024011289700865746,
0.009510219097137451,
-0.022366838529706,
-0.047148603945970535,
-0.027737179771065712,
0.028105169534683228,
0.03114107809960842,
0.034958966076374054,
0.043790705502033234,
-0.010780931450426579,
0.019825413823127747,
0.04006481543183327,
0.02398828975856304,
-0.01637551560997963,
0.0704239159822464,
-0.0035965186543762684,
-0.01614552177488804,
-0.0020742511842399836,
-0.009130730293691158,
0.010723432525992393,
-0.012477130629122257,
0.0011787151452153921,
0.006175317335873842,
-0.006238565314561129,
0.03958182781934738,
0.008544247597455978,
0.00819350779056549,
0.036476921290159225,
-0.045699648559093475,
0.010292195715010166,
-0.035740941762924194,
-0.012017144821584225,
0.018307458609342575,
0.01626051962375641,
-0.01422507967799902,
-0.07410380989313126,
0.014179080724716187,
-0.0028016045689582825,
-0.028979143127799034,
0.018238460645079613,
-0.013431603088974953,
-0.014719564467668533,
0.08311954140663147,
0.023689299821853638,
0.05188646540045738,
0.044411685317754745,
0.019077936187386513,
0.010412941686809063,
-0.006307563278824091,
0.006307563278824091,
-0.02644921839237213,
0.020538393408060074,
-0.017916470766067505,
0.005905075464397669,
0.026403218507766724,
-0.006146568339318037,
0.003843761282041669,
-0.009314724244177341,
0.014156081713736057,
0.026518216356635094,
0.03758088871836662,
-0.003556269919499755,
-0.02610422857105732,
-0.020676389336586,
0.04017981141805649,
-0.007647273596376181,
0.017479483038187027,
0.03889184817671776,
-0.03341801092028618,
0.028933145105838776,
-0.0019348177593201399,
0.01363859698176384,
-0.012385133653879166,
0.013788091950118542,
0.028588155284523964,
0.012442631646990776,
-0.03528095781803131,
-0.005062725394964218,
0.0508744940161705,
-0.011821649968624115,
-0.03079608827829361,
0.010073701851069927,
0.007653023581951857,
-0.009492969140410423,
0.010953426361083984,
-0.03461397439241409,
0.02348230592906475,
-0.03953583166003227,
0.011200668290257454,
-0.0017709475941956043,
-0.07741571217775345,
0.036867909133434296,
0.019422926008701324,
0.035740941762924194,
0.025414248928427696,
-0.031325072050094604,
0.01861794851720333,
-0.0232063140720129,
0.0017853222088888288,
-0.013661595992743969,
0.030428100377321243,
-0.0463896282017231,
-0.017755474895238876,
0.00888923741877079,
-0.07626574486494064,
-0.01704249531030655,
0.03001411259174347,
0.058556269854307175,
-0.04540065675973892,
-0.01877894438803196,
-0.011971145868301392,
0.0008933798526413739,
0.04224975034594536,
0.00896973442286253,
-0.023102816194295883,
0.008952485397458076,
-0.05395640432834625,
-0.015007056295871735,
-0.012304635718464851,
0.0001498549390817061,
0.015444043092429638,
0.00487873051315546,
0.03709790110588074,
0.00410825340077281,
0.020607391372323036,
0.029922114685177803,
-0.00043051852844655514,
-0.009584966115653515,
-0.014811561442911625,
0.011079922318458557,
-0.029922114685177803,
0.04427368938922882,
0.027484187856316566,
-0.006089069880545139,
0.010217447765171528,
-0.0006080445018596947,
0.01990591175854206,
-0.01615702174603939,
0.010654434561729431,
0.0077392710372805595,
-0.010004703886806965,
0.03162406384944916,
-0.025805236771702766,
0.05579635128378868,
-0.014075583778321743,
-0.049218542873859406,
0.010740682482719421,
-0.021216873079538345,
0.008009512908756733,
0.02661021240055561,
-0.005097224377095699,
0.0162030216306448,
0.04579164460301399,
0.01043019164353609,
0.06278814375400543,
0.029945114627480507,
0.031831059604883194,
-0.01098217535763979,
0.012201138772070408,
0.023010820150375366,
-0.020653389394283295,
-0.019917411729693413,
-0.023102816194295883,
-0.06030421704053879,
0.0024494274985045195,
-0.010913177393376827,
0.008710992522537708,
-0.0063248127698898315,
-0.018709946423768997,
0.029600124806165695,
-0.008113009855151176,
0.0034556477330625057,
-0.020526893436908722,
-0.015789033845067024,
-0.0530824288725853,
-0.02594323270022869,
-0.041444774717092514,
0.0346599742770195,
-0.021446865051984787,
-0.008498248644173145,
0.01631801761686802,
-0.015662536025047302,
0.0040018814615905285,
-0.0019894412253051996,
0.04259473830461502,
-0.02582823671400547,
-0.018410954624414444,
-0.006347812246531248,
-0.007101039867848158,
0.02398828975856304,
-0.0081072598695755,
0.007060791365802288,
0.021113375201821327,
0.007969263941049576,
-0.004410119727253914,
0.032682035118341446,
-0.012684124521911144,
0.022378338500857353,
-0.04574564844369888,
0.0032515288330614567,
0.009032982401549816,
-0.0028073545545339584,
0.0006411060458049178,
-0.0037747633177787066,
-0.05506037175655365,
-0.014788562431931496,
0.014271077699959278,
-0.023125816136598587,
0.003590768901631236,
0.0192849300801754,
-0.032613035291433334,
-0.0055198366753757,
0.003090533660724759,
-0.0054192147217690945,
-0.009924206882715225,
-0.036982905119657516,
0.029163137078285217,
-0.04204275831580162,
-0.004792483057826757,
0.0029209135100245476,
-0.024333279579877853,
0.05174846947193146,
-0.009803459979593754,
-0.014271077699959278,
0.018813444301486015,
-0.0017522607231512666,
0.0025701739359647036,
-0.01895144023001194,
-0.01140191312879324,
0.007204536814242601,
0.037488892674446106,
-0.020584391430020332,
-0.008354502730071545,
-0.029094139114022255,
-0.00729653425514698,
-0.0206878874450922,
0.013270607218146324,
0.01856045052409172,
0.00014401527005247772,
0.030842088162899017,
0.0018859441624954343,
0.004323872271925211,
0.017260989174246788,
0.0025011759717017412,
-0.007900265976786613,
-0.019491923972964287,
-0.023240812122821808,
0.022378338500857353,
0.0007999450899660587,
-0.0037488890811800957,
-0.035855937749147415,
-0.02621922455728054,
0.00034211488673463464,
-0.008498248644173145,
-0.005876326002180576,
-0.0012843682197853923,
-0.002498301211744547,
0.04684961587190628,
0.033395010977983475,
-0.0015998901799321175,
0.02034289762377739,
0.03459097817540169,
0.026564214378595352,
-0.002969787223264575,
-0.03079608827829361,
0.004778108559548855,
-0.01394908782094717,
-0.007072290871292353,
-0.007417280692607164,
-0.0139720868319273,
-0.0155130410566926,
-0.024632271379232407,
-0.04103078693151474,
-0.020423395559191704,
0.01168365404009819,
0.036085933446884155,
0.02822016552090645,
0.016180021688342094,
-0.006675552576780319,
-0.03190005570650101,
0.042456742376089096,
-0.014075583778321743,
-0.013408603146672249,
0.012235637754201889,
-0.02638022042810917,
-0.028657153248786926,
-0.012063142843544483,
0.005893575493246317,
0.03146306797862053,
-0.002437927993014455,
-0.01252312958240509,
0.00329177756793797,
0.012408132664859295,
0.0012599314795807004,
-0.012626626528799534,
0.00838325172662735,
0.019434425979852676,
-0.02326381206512451,
-0.0290711410343647,
0.026058228686451912,
-0.004030630923807621,
0.017203491181135178,
-0.031670063734054565,
0.01310961227864027,
0.0335330069065094,
0.06209816411137581,
0.059890229254961014,
-0.0273921899497509,
-0.0024149285163730383,
-0.0037460140883922577,
-0.022148344665765762,
-0.012086142785847187,
-0.009239976294338703,
-0.027415189892053604,
-0.015662536025047302,
0.000881161424331367,
-0.003260153578594327,
0.0698719322681427,
0.009326224215328693,
0.01811196468770504,
-0.000004868264113611076,
-0.00821650680154562,
0.020503893494606018,
0.007578275632113218,
-0.00535309175029397,
-0.019491923972964287,
0.0028317912947386503,
-0.003380900016054511,
0.006278814282268286,
-0.02398828975856304,
-0.04779258742928505,
0.011752652004361153,
0.012086142785847187,
-0.015685535967350006,
0.0162030216306448,
0.01599602773785591,
-0.007658773567527533,
0.006997542921453714,
-0.025529244914650917,
-0.016479013487696648,
0.007520777639001608,
-0.005680832080543041,
0.026909204199910164,
0.00387826026417315,
-0.014133081771433353,
-0.004070879425853491,
-0.03263603523373604,
0.04126077890396118,
0.029692120850086212,
0.013040614314377308,
0.0002251417754450813,
0.032061051577329636,
-0.015501541085541248,
-0.019158434122800827,
-0.04215775430202484,
0.02168835885822773,
0.03923683986067772,
0.007785269524902105,
-0.002519862959161401,
-0.03484397009015083,
-0.02973812073469162,
-0.016892999410629272,
0.01795096881687641,
-0.0022740578278899193,
0.022010348737239838,
0.02497726120054722,
0.02364329993724823,
0.023436306044459343,
-0.002351680537685752,
-0.021722856909036636,
0.009429721161723137,
-0.003030160441994667,
0.04252574220299721,
-0.016858501359820366,
0.060626205056905746,
-0.005577335134148598,
0.008866237476468086,
-0.003817887045443058,
-0.03252103924751282,
0.001678950386121869,
0.004812607541680336,
-0.014455072581768036,
0.005013851914554834,
-0.0575902983546257,
-0.025575242936611176,
-0.0023545552976429462,
0.012477130629122257,
0.02287282422184944,
-0.051564473658800125,
-0.01363859698176384,
-0.0013670220505446196,
-0.007543776649981737,
0.04346871376037598,
0.029922114685177803,
0.023965291678905487,
-0.018709946423768997,
-0.015662536025047302,
-0.003441273234784603,
0.00700329290702939,
-0.00009523156040813774,
-0.010269196704030037,
-0.018008466809988022,
-0.017134493216872215,
0.007819768972694874,
0.004507866688072681,
0.006457059178501368,
0.023551303893327713,
-0.027714179828763008,
0.005787204019725323,
0.011620406061410904,
0.0026650461368262768,
-0.006658303085714579,
0.019756415858864784,
0.026794208213686943,
0.004045005422085524,
-0.04291673004627228,
0.015685535967350006,
-0.034521978348493576,
-0.018353456631302834,
-0.011787150986492634,
-0.00922272726893425,
0.006721551064401865,
0.02184935286641121,
-0.012695624493062496,
-0.005508337169885635,
-0.00482123252004385,
0.026403218507766724,
-0.003849511034786701,
0.015053054317831993,
-0.027990171685814857,
-0.003987506963312626,
0.006842297501862049,
-0.005370341241359711,
0.013627097010612488,
0.015271548181772232,
-0.01737598516047001,
-0.00464011263102293,
-0.003142282133921981,
0.021366367116570473,
-0.04779258742928505,
0.010050702840089798,
-0.010976425372064114,
0.024057287722826004,
0.034406982362270355,
-0.09273325651884079,
-0.024839265272021294,
0.013017615303397179,
-0.02029689960181713,
0.008590245619416237,
0.022930322214961052,
-0.007819768972694874,
-0.0310260821133852,
-0.008607495576143265,
-0.03265903517603874,
0.024494275450706482,
-0.02762218378484249,
0.021676858887076378,
-0.015283048152923584,
-0.008687992580235004,
-0.011281166225671768,
-0.01776697486639023,
-0.05892425775527954,
0.022493334487080574,
0.04287073016166687,
-0.002581673674285412,
0.028427159413695335,
0.03771888464689255,
0.03146306797862053,
0.025920232757925987,
0.035809941589832306,
-0.03718990087509155,
-0.009694213047623634,
-0.017571480944752693,
-0.003901259507983923,
-0.006790549028664827,
0.007624274585396051,
-0.012281636707484722,
0.015616538003087044,
0.0011571532813832164,
-0.045032668858766556,
0.013006115332245827,
-0.006388061214238405,
0.011700903996825218,
0.02330981008708477,
0.007549526635557413,
0.017306987196207047,
0.005583084654062986,
0.04388270154595375,
-0.03137107193470001,
-0.010671684518456459,
-0.02594323270022869,
0.025621242821216583,
-0.011971145868301392,
-0.02688620425760746,
0.06807798892259598,
-0.04408969730138779,
-0.006848047487437725,
0.002469551982358098,
-0.009176728315651417,
-0.020032407715916634,
0.02789817564189434,
-0.009688463062047958,
0.0430547259747982,
0.016559509560465813,
-0.03606293350458145,
0.024057287722826004,
0.03293502703309059,
0.0017867597052827477,
-0.003610893152654171,
-0.012684124521911144,
-0.04333071783185005,
0.023160314187407494,
-0.03672991320490837,
-0.005151847843080759,
-0.010924676433205605,
0.021446865051984787,
-0.03380899876356125,
0.02582823671400547,
-0.018238460645079613,
-0.011821649968624115,
-0.013466102071106434,
0.00852699764072895,
0.007664523087441921,
0.028657153248786926,
-0.014604568481445312,
-0.015731533989310265,
0.021561862900853157,
0.02437927946448326,
-0.025644240900874138,
-0.011562908068299294,
0.018686946481466293,
0.022734828293323517,
-0.013178610242903233,
-0.016892999410629272,
0.02186085283756256,
-0.003950132988393307,
-0.03180805966258049,
0.012753122486174107,
-0.009441221132874489,
0.005784329026937485,
-0.027346191927790642,
0.021113375201821327,
0.023240812122821808,
-0.0020713761914521456,
0.037879880517721176,
-0.01037269365042448,
-0.022539332509040833,
-0.01637551560997963,
-0.020883383229374886,
-0.008061261847615242,
0.05455438792705536,
-0.004076629411429167,
0.008371752686798573,
-0.007509277667850256,
0.041398774832487106,
0.011275416240096092,
0.01821546070277691,
0.0026017981581389904,
0.006514557171612978,
-0.005985572934150696,
0.01665150746703148,
-0.023010820150375366,
0.03615492954850197,
-0.002235246356576681,
0.06996393203735352,
0.0268402062356472,
0.0155130410566926,
-0.03525795787572861,
-0.0056290836073458195,
-0.005166222341358662,
0.017525481060147285,
0.023447806015610695,
0.02326381206512451,
-0.02817416749894619,
0.013316606171429157,
0.025460246950387955,
-0.0005695925210602582,
-0.020917881280183792,
-0.001735011232085526,
0.03447597846388817,
0.030842088162899017,
0.03201505169272423,
-0.010326694697141647,
0.018019966781139374,
-0.0117354029789567,
-0.01777847483754158,
0.008998483419418335,
-0.03735089674592018,
0.014650566503405571,
-0.002378992037847638,
-0.035694945603609085,
0.0022151218727231026,
0.003297527553513646,
0.02700120210647583,
-0.030497098341584206,
0.013834090903401375,
-0.014719564467668533,
0.014547069557011127,
0.01112592127174139,
0.017812972888350487,
0.029439128935337067,
-0.006635303609073162,
0.006365061737596989,
-0.0189974382519722,
-0.03817887231707573,
0.0313020758330822,
-0.03309602290391922,
0.0009293162729591131,
0.025782236829400063,
-0.02403428964316845,
-0.01737598516047001,
0.008055511862039566,
0.023447806015610695,
0.033785998821258545,
0.02191835083067417,
-0.06472008675336838,
0.038155872374773026,
-0.0017062620026990771,
-0.02649521641433239,
-0.019238930195569992,
0.05036851018667221,
0.004326746799051762,
0.012730123475193977,
0.024402277544140816,
-0.028749149292707443,
-0.004757984075695276,
0.007957764901220798,
0.005755579564720392,
0.034061990678310394,
-0.009768960997462273,
0.05450838804244995,
-0.027530185878276825,
0.018077464774250984,
0.034061990678310394,
-0.014363075606524944,
-0.018882442265748978,
-0.00986670795828104,
0.031164078041911125,
0.008687992580235004,
-0.023516803979873657,
-0.013075113296508789,
0.0029467877466231585,
-0.04420469328761101,
-0.021389367058873177,
0.0021619361359626055,
0.04238774627447128,
0.04109978303313255,
0.002531362697482109,
-0.014087083749473095,
0.017536981031298637,
0.009090481325984001,
-0.0391218438744545,
-0.030819088220596313,
0.018905440345406532,
-0.0007532277377322316,
0.013707594946026802,
-0.011925146915018559,
-0.005675082094967365,
0.009124980308115482,
-0.0015697035705670714,
-0.003579269163310528,
0.005240969825536013,
-0.0036626416258513927,
-0.025000261142849922,
0.0070320419035851955,
-0.03923683986067772,
-0.028657153248786926,
0.014420573599636555,
-0.006048820912837982,
0.019353928044438362,
0.029025141149759293,
0.03001411259174347,
-0.0178934708237648,
0.013535100035369396,
-0.048988550901412964,
0.008176257833838463,
0.012569128535687923,
0.010470440611243248,
0.003435523482039571,
0.009619465097784996,
-0.005390465725213289,
-0.058556269854307175,
0.019480424001812935,
-0.006687052082270384,
0.05529036372900009,
0.02704720012843609,
-0.00535309175029397,
-0.023574301972985268,
-0.029807118698954582,
0.016352515667676926,
0.04287073016166687,
-0.03813287243247032,
0.006560556124895811,
-0.011810150928795338,
-0.010901677422225475,
-0.009228477254509926,
0.030037110671401024,
0.031785059720277786,
0.04227275028824806,
0.008457999676465988,
-0.019744915887713432,
0.02610422857105732,
0.03169306367635727,
0.02145836502313614,
-0.008044011890888214,
-0.002995661459863186,
0.009481469169259071,
-0.022677328437566757,
0.024678269401192665,
-0.011079922318458557,
-0.010688933543860912,
0.0041312528774142265,
0.0002786870754789561,
0.014351575635373592,
0.00953321810811758,
0.026518216356635094,
-0.0036195178981870413,
0.033740002661943436,
0.02229784056544304,
0.002588860923424363,
0.04615963622927666,
-0.014719564467668533,
0.02477026730775833,
0.013546599075198174,
-0.005568710155785084,
-0.0013713344233110547,
-0.0038236367981880903,
0.017985468730330467,
0.029876116663217545,
0.011787150986492634,
-0.017985468730330467,
-0.00700329290702939,
0.02723119407892227,
-0.04293972998857498,
-0.024954261258244514,
0.0017191991209983826,
-0.00024041476717684418,
0.0016502011567354202,
0.005177721846848726,
-0.01951492205262184,
0.013788091950118542,
-0.027921173721551895,
-0.004231874831020832,
-0.017088495194911957,
0.026955202221870422,
0.007894516922533512,
-0.023666299879550934,
0.00021094689145684242,
0.017421985045075417,
-0.020756885409355164,
-0.01369609497487545,
-0.03498196601867676,
0.03348701074719429,
0.012224138714373112,
-0.07640373706817627,
0.004096753895282745,
0.026794208213686943,
-0.014696565456688404,
0.037304896861314774,
0.010665934532880783,
-0.019215932115912437,
0.03125607594847679,
-0.007221786305308342,
0.008785740472376347,
0.007400031201541424,
0.008981234394013882,
0.0363389253616333,
-0.03238304331898689,
-0.038546860218048096,
-0.007658773567527533,
0.003642517374828458,
-0.016847001388669014,
-0.004361245781183243,
-0.035188958048820496,
0.007911765947937965,
-0.010067951865494251,
0.012120641767978668,
0.01905493624508381,
0.02268882840871811,
0.025690240785479546,
0.0013095238246023655,
-0.020595891401171684,
-0.005804453510791063,
0.02957712486386299,
-0.01081543043255806,
0.015467042103409767,
0.004533740691840649,
0.008590245619416237,
0.008038261905312538,
0.013535100035369396,
-0.0054220897145569324,
-0.010401442646980286,
-0.004139877390116453,
-0.0042146253399550915,
0.05202446132898331,
0.004320997279137373,
-0.04130677878856659,
0.06683602184057236,
0.020641889423131943,
0.008268255740404129,
-0.00427499832585454,
0.035303954035043716,
0.014570069499313831,
0.002261120593175292,
-0.02080288529396057,
0.017410485073924065,
0.03238304331898689,
-0.013282107189297676,
0.0024163660127669573,
-0.0025960481725633144,
-0.0369139090180397,
-0.0335330069065094,
-0.0013713344233110547,
0.005166222341358662,
-0.00013323433813638985,
0.031233076006174088,
-0.014041084796190262,
-0.0012800558470189571,
0.00687679648399353,
0.031233076006174088,
0.02688620425760746,
0.005557210650295019,
-0.018847942352294922,
0.036361925303936005,
0.02555224485695362,
-0.01098217535763979,
-0.0029554124921560287,
-0.025621242821216583,
-0.00854999665170908,
-0.0324060432612896,
-0.0273921899497509,
-0.01627201959490776,
0.010769431479275227,
-0.008929485455155373,
-0.016812503337860107,
-0.021607860922813416,
0.033395010977983475,
-0.01805446669459343,
-0.01145941112190485,
-0.01750248298048973,
0.011338664218783379,
0.009602216072380543,
-0.007808269001543522,
0.020411895588040352,
-0.0279441736638546,
-0.013247608207166195,
0.002670795889571309,
-0.005755579564720392,
0.008848988451063633,
0.03735089674592018,
-0.0031624063849449158,
-0.006664053071290255,
-0.0029812867287546396,
-0.024793267250061035,
-0.0070377918891608715,
0.02157336100935936,
-0.06338612735271454,
0.01732998713850975,
-0.0273921899497509,
0.006152317859232426,
-0.0031652813777327538,
-0.01140191312879324,
-0.033234018832445145,
-0.02801317162811756,
-0.01995190978050232,
0.006807798519730568,
0.008170508779585361,
-0.010050702840089798,
-0.02268882840871811,
0.00813600979745388,
0.0117354029789567,
0.010522188618779182,
-0.018088964745402336,
0.028910145163536072,
0.0220793467015028,
0.0020426271948963404,
0.006054570898413658,
-0.022539332509040833,
-0.03277403116226196,
0.054692383855581284,
-0.005859076511114836,
0.017962468788027763,
-0.02649521641433239,
0.016065025702118874,
0.013144111260771751,
-0.023171814158558846,
0.041168782860040665,
-0.0006612304132431746,
0.019940409809350967,
-0.016892999410629272,
-0.010631435550749302,
0.023171814158558846,
0.02247033454477787,
0.0022683078423142433,
0.02743818797171116,
0.0005764204543083906,
-0.010056452825665474,
0.0026061104144901037,
-0.044181693345308304,
-0.0012750248424708843,
-0.03316501900553703,
-0.019687417894601822,
0.002052689203992486,
0.02051539346575737,
-0.050276514142751694,
-0.010292195715010166,
-0.012672625482082367,
0.0013713344233110547,
-0.0007884454098530114,
0.01582353189587593,
-0.002652109134942293,
-0.004573989659547806,
-0.014788562431931496,
0.027921173721551895,
-0.030267104506492615,
0.01400658581405878,
0.010918927378952503,
-0.005689456593245268,
0.011971145868301392,
-0.025920232757925987,
0.03896084800362587,
-0.028151167556643486,
0.019146934151649475,
-0.0002608985232654959,
-0.03571794182062149,
0.0011147483019158244,
0.02801317162811756,
-0.0009602215723134577,
0.02145836502313614,
0.024241283535957336,
-0.03516595810651779,
-0.018571950495243073,
0.023045318201184273,
-0.013546599075198174,
0.0021073126699775457,
-0.009383722208440304,
-0.010556687600910664,
0.008981234394013882,
-0.0029166012536734343,
-0.006152317859232426,
0.022447336465120316,
-0.02190685272216797,
-0.0011657780269160867,
-0.011764151975512505,
0.003084783675149083,
-0.024862265214323997,
0.011752652004361153,
-0.002995661459863186,
0.009659714065492153,
0.025299251079559326,
-0.055428359657526016,
-0.07401181012392044,
0.016065025702118874,
0.006641053594648838,
-0.03314201906323433,
-0.016076523810625076,
-0.008354502730071545,
0.01782447285950184,
0.03656891733407974,
-0.026173226535320282,
-0.014650566503405571,
0.03415399044752121,
-0.01962991990149021,
-0.008630494587123394,
-0.012304635718464851,
0.006922795437276363,
0.02309131622314453,
-0.012557628564536572,
-0.01821546070277691,
-0.037419892847537994,
0.0192849300801754,
0.015421044081449509,
-0.018698446452617645,
-0.015432543121278286,
0.043123725801706314,
-0.019928909838199615,
-0.009377972222864628,
-0.009418221190571785,
-0.009285975247621536,
0.04277873411774635,
0.025759238749742508,
-0.009021483361721039,
-0.016674507409334183,
-0.023401807993650436,
-0.023010820150375366,
0.0063363127410411835,
0.02213684469461441,
-0.001993753481656313,
-0.0007287909393198788,
0.05501437187194824,
0.006784799508750439,
0.013615597039461136,
0.0019463173812255263,
0.04059379920363426,
0.012891118414700031,
-0.013477601110935211,
0.022907322272658348,
0.008981234394013882,
-0.00938947219401598,
-0.0542323961853981,
0.015674035996198654,
-0.009228477254509926,
-0.04057079926133156,
0.0009609403205104172,
0.02700120210647583,
0.018376456573605537,
0.03052009642124176,
0.02805916965007782,
-0.027691181749105453,
0.013190110214054585,
-0.0056204586289823055,
-0.022930322214961052,
-0.031003082171082497,
-0.014075583778321743,
-0.012477130629122257,
-0.006468558683991432,
-0.005217970814555883,
0.014742563478648663,
-0.007635774090886116,
0.02845015935599804,
0.00905598234385252,
-0.0022064971271902323,
-0.014294077642261982,
-0.033510010689496994,
-0.018755944445729256,
0.016536511480808258,
-0.029830116778612137,
0.013627097010612488,
-0.028818147256970406,
-0.020676389336586,
-0.02286132425069809,
0.005974073428660631,
-0.03459097817540169,
-0.007256285287439823,
-0.03654591739177704,
0.00588495098054409,
0.03442998230457306,
-0.01486906036734581,
-0.005390465725213289,
0.04599864035844803,
-0.0019865662325173616,
0.011384663172066212,
-0.020250901579856873,
-0.03419998660683632,
-0.029002143070101738,
0.010148449800908566,
0.016088023781776428,
-0.05174846947193146,
-0.023505304008722305,
-0.006641053594648838,
-0.010941926389932632,
-0.010959175415337086,
-0.022849824279546738,
-0.00744602968916297,
-0.009176728315651417,
0.011700903996825218,
0.008400501683354378,
-0.024885263293981552,
0.021331869065761566,
0.026587214320898056,
-0.03590193763375282,
0.0064168102107942104,
0.005318592768162489,
0.022171344608068466,
0.010918927378952503,
0.03668391332030296,
-0.00020932975166942924,
-0.005893575493246317,
0.0032199048437178135,
0.013592598028481007,
-0.03063509427011013,
0.02861115336418152,
0.04385970160365105,
-0.012661125510931015,
0.014144581742584705,
0.03905284404754639,
0.02527625299990177,
-0.032889027148485184,
0.014696565456688404,
-0.021504363045096397,
-0.031785059720277786,
0.00570095656439662,
-0.014328576624393463,
-0.003967382479459047,
-0.010890177451074123,
0.03162406384944916,
0.003403899259865284,
0.028657153248786926,
-0.0413757748901844,
-0.0006576367886736989,
-0.018180962651968002,
-0.006681302562355995,
0.007785269524902105,
-0.014846060425043106,
-0.02918613702058792,
-0.005238095298409462,
-0.010987925343215466,
0.033510010689496994,
0.02391929179430008,
0.024839265272021294,
-0.009004233404994011,
0.014052584767341614,
0.008705242536962032,
-0.011321415193378925,
0.02403428964316845,
-0.010182948783040047,
0.0065433066338300705,
0.015271548181772232,
-0.007549526635557413,
0.004366995766758919,
0.010280695743858814,
0.028703151270747185,
-0.024586273357272148,
-0.018192462623119354,
-0.048436567187309265,
0.011033923365175724,
-0.025897234678268433,
0.014788562431931496,
0.10929276794195175,
-0.02140086703002453,
0.015674035996198654,
0.002233808860182762,
-0.020722387358546257,
-0.01011970080435276,
0.027369190007448196,
-0.006278814282268286,
0.013454602099955082,
-0.029094139114022255,
0.016525011509656906,
-0.004683236591517925,
0.027254194021224976,
0.018088964745402336,
0.03833986446261406,
-0.007802519015967846,
0.006468558683991432,
0.05069050192832947,
-0.015559040009975433,
0.03488996624946594,
0.0001994472258957103,
0.011275416240096092,
0.005548585671931505,
0.017249489203095436,
0.000528984353877604,
-0.028036171570420265,
0.019664417952299118,
-0.018882442265748978,
0.011131670325994492,
-0.006779049523174763,
0.032061051577329636,
-0.0198369137942791,
0.01743348501622677,
-0.029761118814349174,
0.017456483095884323,
-0.011108671315014362,
-0.045354656875133514,
-0.042732734233140945,
0.015478542074561119,
0.010355443693697453,
0.01688150130212307,
0.013040614314377308,
0.0054192147217690945,
-0.0025112382136285305,
0.04537765681743622,
-0.005373216234147549,
-0.0469646118581295,
0.002294182078912854,
0.00991845689713955,
0.003984631970524788,
-0.0008969734772108495,
0.012994615361094475,
0.005818828009068966,
-0.010665934532880783,
-0.016950499266386032,
-0.029439128935337067,
-0.00006783002754673362,
-0.011396163143217564,
-0.007423030212521553,
-0.04682661592960358,
-0.03709790110588074,
0.016122523695230484,
0.004188751336187124,
-0.02336730808019638,
0.006347812246531248
] | 2025-01-07 | 40 | 39762074 | [
"T cells",
"CRC cells",
"CEA expression",
"CEA",
"CAR",
"CEA-negative CT26 cells",
"reg-CAR T cells",
"CEA-specific CAR-T cells",
"tumor tissues",
"CEA)-specific chimeric antigen receptor",
"similar positive proportions",
"co-culture system",
"CEA-positive tumors",
"endogenous CD8",
"the CEA-specific 7XCL1-CAR T cells",
"carcinoembryonic antigen",
"a conventional CEA CAR",
"7XCL1-CAR and reg-CAR T cells",
"CD8 ratios",
"distinct microenvironments",
"Therapeutic efficacy",
"7XCL1-CAR T cells",
"lymphotactin XCL1",
"cell-cultures",
"CEA-CAR",
"CEA-specific, XCL1-secreting CAR-T cells",
"CRC",
"colorectal cancer",
"CD8",
"culture"
] | [
"Chimeric antigen receptor - CAR",
"Colorectal Cancer",
"Dendritic",
"Immunotherapy",
"T cell"
] | 0 | 10.1136/jitc-2024-010581
10.1001/jama.2021.0106
10.1016/j.eclinm.2021.101134
10.1136/jitc-2020-001097
10.1016/j.ymthe.2017.03.010
10.1186/s13045-020-00890-6
10.3389/fimmu.2022.841425
10.1186/s12943-023-01723-z
10.1038/nbt.4086
10.1038/mt.2013.262
10.1016/j.ccell.2022.04.006
10.1016/j.cell.2020.08.053
10.1038/s41586-023-06063-y
10.1146/annurev-immunol-042617-053402
10.1146/annurev-immunol-051116-052415
10.1016/j.ccell.2022.02.013
10.1016/j.immuni.2009.01.007
10.1038/s41577-019-0210-z
10.1016/j.ccell.2016.06.003
10.1073/pnas.1513607113
10.1016/j.ccell.2017.04.003
10.1126/sciimmunol.abg7836
10.1016/j.immuni.2021.08.026
10.1016/j.immuni.2018.12.021
10.1038/s41590-019-0312-6
10.1186/s40425-019-0685-y
10.1158/2326-6066.CIR-19-0210
10.1111/j.1745-7254.2005.00177.x
10.1080/19420862.2015.1008351
10.1016/j.ymthe.2017.06.008
10.1007/s00262-021-02853-3
10.1158/1078-0432.CCR-20-0777
10.1038/s41590-020-0676-7
10.1002/eji.201242603
10.3389/fimmu.2023.1166180
10.1016/j.ccell.2019.10.006
10.1038/nri1001
10.1158/2326-6066.CIR-19-0251
10.1136/gut.30.9.1260
10.1007/s10555-013-9444-6
10.1053/j.gastro.2012.06.037 | [
"Li",
"Wang",
"Chen",
"Wu",
"Zhang",
"Xiao",
"Zhao",
"Wang",
"Zhao",
"Ran",
"Qu"
] | [
"Immunology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"Immunology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"Immunology Department, State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [email protected] [email protected] [email protected].",
"Immunology Department, State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"Immunology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"Immunology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"Immunology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"Immunology Department, State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"Department of Hepatobiliary Surgery, State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.",
"State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [email protected] [email protected] [email protected].",
"Immunology Department, State Key Lab of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [email protected] [email protected] [email protected]."
] | [
"39762074",
"33591350",
"32843493",
"28366766",
"32423475",
"35401510",
"36717905",
"29505028",
"24213558",
"35487216",
"33064988",
"30550719",
"29328785",
"35303421",
"19285437",
"31467405",
"27424807",
"26755602",
"28486109",
"34597124",
"34534439",
"30635237",
"30778252",
"31391096",
"31666238",
"8598468",
"16174444",
"25621616",
"28676342",
"33559069",
"32816947",
"32424363",
"23124877",
"37622122",
"31761658",
"12563297",
"31719059",
"2806995",
"23903773",
"22750462"
] | [] | 9.384993 | 5.857348 |
39761676 | 73 | mRNA-laden lipid nanoparticle-enabled humanized CD19 CAR-T-cell engineering for the eradication of leukaemic cells. | Chimeric antigen receptor T-cell (CAR-T) therapy has shown transformative potential in treating malignant tumours, with increasing global approval of CAR-T products. However, high-production costs and risks associated with viral vector-based CAR-T cells-such as insertional mutagenesis and secondary tumour formation-remain challenges. Our study introduces an innovative CAR-T engineering approach using mRNA delivered via lipid nanoparticles (LNPs), aiming to reduce costs and enhance safety while maintaining strong anti-tumour efficacy. We developed an LNP-based transfection protocol for efficient delivery of mRNA encoding full-human CAR constructs, achieving high CAR expression and significant cytotoxicity against leukaemic cells in vitro. Co-culture with Raji cells showed increased cytokine secretion and tumour cell killing by mRNA-LNP CAR-T cells. Therapeutic efficacy was further demonstrated in an NOD-scid-IL2Rγnull (NSG) mouse model with Raji engraftment, where treated mice exhibited marked tumour regression and extended survival. These findings underscore the potential of mRNA-LNPs as a non-viral, effective CAR-T engineering platform, offering a promising alternative to traditional methods that could improve CAR-T safety, efficacy and accessibility in clinical cancer immunotherapy. | [
0.015830691903829575,
-0.007984576746821404,
0.01926913671195507,
0.020688360556960106,
-0.024346036836504936,
-0.03263061121106148,
0.017434531822800636,
0.007424964103847742,
0.00029549136525020003,
-0.03726905211806297,
-0.005451896693557501,
-0.0010766774648800492,
-0.08312267810106277,
-0.000725116697140038,
0.007534578908234835,
-0.050492063164711,
0.023769116029143333,
-0.026538332924246788,
0.010649948380887508,
0.026053719222545624,
0.0022932582069188356,
0.02981523983180523,
-0.01921144500374794,
-0.009974951855838299,
-0.000126652026665397,
-0.02960754930973053,
0.04993822053074837,
0.00984225980937481,
-0.03092292696237564,
-0.03223830461502075,
0.009871105663478374,
-0.023549886420369148,
-0.023815268650650978,
0.0009115340653806925,
-0.014007624238729477,
0.036738283932209015,
0.038907505571842194,
-0.0005412233294919133,
-0.012346094474196434,
-0.021046051755547523,
0.025522952899336815,
0.0018764332635328174,
0.03383060544729233,
0.07255349308252335,
-0.04296902194619179,
-0.014619160443544388,
-0.04439978674054146,
-0.027346022427082062,
0.007338426075875759,
0.027346022427082062,
-0.03133831173181534,
-0.0005862952675670385,
-0.020746054127812386,
0.0302536990493536,
-0.07324580103158951,
0.02776140347123146,
-0.022949889302253723,
0.000006941072115296265,
0.004199979826807976,
0.017734529450535774,
0.0049182455986738205,
-0.025638338178396225,
0.021519126370549202,
-0.023272965103387833,
-0.05639972537755966,
-0.014192239381372929,
-0.08755341917276382,
-0.018934523686766624,
-0.0028038325253874063,
0.03636905550956726,
0.029884470626711845,
-0.04846130311489105,
-0.029561394825577736,
-0.008048037998378277,
0.03371522203087807,
-0.028338324278593063,
-0.01923452317714691,
0.04823053628206253,
0.017388377338647842,
0.004704785067588091,
0.04133056849241257,
-0.007592271082103252,
0.025869105011224747,
-0.03659982234239578,
-0.012126864865422249,
-0.020919129252433777,
0.03168446198105812,
-0.02084989845752716,
-0.07370733469724655,
-0.015530694276094437,
-0.0352613665163517,
0.029746009036898613,
-0.03581521287560463,
0.06849197298288345,
-0.017965298146009445,
0.054045893251895905,
-0.017030686140060425,
-0.030853696167469025,
0.09221494197845459,
0.03833058476448059,
0.051553595811128616,
0.0023062387481331825,
0.02084989845752716,
-0.005509588867425919,
0.052615128457546234,
0.026515256613492966,
-0.02644602581858635,
0.010788409039378166,
0.010603794828057289,
0.007338426075875759,
0.07144580781459808,
0.008705726824700832,
0.0016009537503123283,
0.046522852033376694,
-0.01022302731871605,
-0.06170739233493805,
-0.0028211402241140604,
-0.0014841274823993444,
0.007194195874035358,
0.029030628502368927,
-0.053168974816799164,
-0.005838433280587196,
0.038030583411455154,
-0.03323061019182205,
0.0064730457961559296,
-0.049799758940935135,
0.04096134006977081,
-0.0035278676077723503,
0.010696101933717728,
-0.06235354393720627,
0.008261498063802719,
0.017146071419119835,
0.010171104222536087,
0.001736530102789402,
-0.06576891243457794,
0.018207604065537453,
-0.015911461785435677,
0.0028110439889132977,
-0.0115672517567873,
0.030669081956148148,
0.027622943744063377,
-0.03200753778219223,
-0.026907561346888542,
-0.019072985276579857,
-0.02538449317216873,
-0.016465304419398308,
-0.029330627992749214,
0.033576760441064835,
-0.012669169344007969,
0.03655366972088814,
-0.021299896761775017,
-0.0020480670500546694,
0.03452290967106819,
0.027184484526515007,
-0.023376809433102608,
-0.06073816865682602,
-0.018703754991292953,
0.0717688798904419,
-0.0034124834928661585,
-0.05390743166208267,
-0.017930682748556137,
0.02494603395462036,
-0.027807557955384254,
-0.028269093483686447,
0.05593819171190262,
-0.011290330439805984,
0.014065316878259182,
-0.0036230594851076603,
-0.06286123394966125,
-0.004352863412350416,
-0.01093840878456831,
-0.03027677722275257,
-0.07518424838781357,
-0.01730760931968689,
-0.02840755507349968,
-0.044561322778463364,
0.014630698598921299,
-0.008526882156729698,
-0.03168446198105812,
-0.017734529450535774,
-0.0012757149524986744,
0.025546031072735786,
0.022096047177910805,
-0.016234537586569786,
-0.0063345846720039845,
0.03664597496390343,
0.008671112358570099,
0.01692684181034565,
-0.025430645793676376,
-0.024692188948392868,
0.005437473766505718,
-0.014042239636182785,
0.04700746387243271,
0.040753647685050964,
0.0138230100274086,
-0.0008430247544310987,
0.053722817450761795,
0.032699842005968094,
0.019488368183374405,
-0.0434536375105381,
0.03486906364560127,
-0.04269210249185562,
-0.02501526288688183,
0.000236357023823075,
-0.027184484526515007,
-0.010009567253291607,
-0.036761362105607986,
0.01923452317714691,
-0.014746082946658134,
-0.002339411759749055,
0.07043042778968811,
0.046545930206775665,
-0.0183345265686512,
-0.008151883259415627,
-0.006167277693748474,
-0.023999884724617004,
-0.02808447927236557,
0.04172287508845329,
0.0053624738939106464,
-0.008578804321587086,
-0.015807615593075752,
-0.02222296968102455,
-0.03334599360823631,
0.01628069020807743,
-0.010078797116875648,
-0.029676780104637146,
0.011544174514710903,
-0.03514598309993744,
0.021069128066301346,
-0.031061388552188873,
-0.005503819324076176,
-0.0007896596216596663,
0.005610549822449684,
-0.04594593122601509,
-0.03246907517313957,
-0.004877861123532057,
0.02644602581858635,
-0.0011098503600805998,
0.017030686140060425,
0.011019177734851837,
0.027899865061044693,
-0.004704785067588091,
0.0209422055631876,
0.007973038591444492,
0.000023031740056467243,
-0.023526810109615326,
-0.038238275796175,
-0.06175354868173599,
0.0342690646648407,
-0.011146100237965584,
-0.010205719619989395,
0.0013298012781888247,
0.009219186380505562,
-0.004912476055324078,
0.012553784996271133,
-0.0006955495337024331,
0.022326815873384476,
-0.00979610625654459,
0.04216133430600166,
-0.02741525135934353,
0.014515314251184464,
0.014053777791559696,
-0.0432920977473259,
-0.02140374295413494,
-0.02907678298652172,
0.021426819264888763,
-0.016569150611758232,
0.04670746624469757,
0.02893832139670849,
0.0062595852650702,
0.04673054441809654,
-0.01099610049277544,
-0.003542290534824133,
-0.007465348578989506,
-0.03212292119860649,
0.04024595767259598,
-0.0032365228980779648,
0.019961442798376083,
-0.0024490265641361475,
0.03447675704956055,
-0.026399873197078705,
0.012553784996271133,
0.005737472325563431,
-0.004595170263200998,
-0.04661515727639198,
-0.019130676984786987,
0.0400613434612751,
-0.008665342815220356,
-0.00534516666084528,
-0.05875356122851372,
0.01713453233242035,
0.009957644157111645,
-0.022442199289798737,
-0.025730645284056664,
0.015138388611376286,
0.02328450232744217,
-0.016130691394209862,
-0.020434517413377762,
-0.03027677722275257,
0.01885375566780567,
-0.04232287034392357,
-0.0029235435649752617,
0.01768837682902813,
-0.06272277235984802,
-0.03530752286314964,
0.03664597496390343,
-0.005526896566152573,
-0.05598434433341026,
-0.02286911942064762,
0.04573823884129524,
0.017399916425347328,
-0.01224224828183651,
0.00960572250187397,
-0.00992879830300808,
0.007713424041867256,
0.016442228108644485,
-0.005348050966858864,
-0.061892006546258926,
0.008734572678804398,
-0.03593059629201889,
-0.018438372761011124,
0.009046110324561596,
-0.02427680604159832,
-0.02090759202837944,
-0.008099961094558239,
-0.0250383410602808,
0.023296041414141655,
-0.012761476449668407,
0.006219200789928436,
-0.005919202230870724,
0.02547680027782917,
-0.04910745471715927,
0.03528444468975067,
-0.004984591156244278,
-0.0165114589035511,
0.000725837831851095,
-0.03103831224143505,
-0.043799787759780884,
0.04472285881638527,
-0.0027158523444086313,
-0.013176859356462955,
0.03846904635429382,
-0.009305723942816257,
0.05441512167453766,
0.013580703176558018,
-0.005844202358275652,
-0.01468839030712843,
0.007713424041867256,
0.001957202097401023,
0.05759971961379051,
-0.019569136202335358,
0.03692289814352989,
0.03013831563293934,
0.02108066715300083,
0.029653701931238174,
0.03696905076503754,
0.009992259554564953,
-0.0032307535875588655,
-0.002645179396495223,
-0.021126821637153625,
-0.02667679451406002,
-0.011324944905936718,
-0.04984591156244278,
0.05672280117869377,
0.05229205638170242,
0.03996903821825981,
0.000696991803124547,
0.024022961035370827,
-0.03013831563293934,
-0.04753823205828667,
0.028776783496141434,
-0.004124979954212904,
0.011965326964855194,
0.020538361743092537,
0.008884572423994541,
0.008705726824700832,
0.001479800557717681,
0.02656140923500061,
0.032076768577098846,
-0.020272979512810707,
0.0581074096262455,
0.0007485540700145066,
-0.010465334169566631,
-0.005930740386247635,
-0.024692188948392868,
0.033253684639930725,
0.04714592546224594,
-0.03233061358332634,
0.0035105599090456963,
0.028269093483686447,
-0.00008297736349049956,
-0.028246017172932625,
0.012323017232120037,
-0.003141331020742655,
0.0017884528497233987,
0.057738181203603745,
0.0083595747128129,
0.060692012310028076,
0.05326128005981445,
0.003902865806594491,
0.003311522537842393,
-0.016142230480909348,
-0.02372296154499054,
-0.012103787623345852,
0.04993822053074837,
-0.020815283060073853,
0.05736895278096199,
0.01625761389732361,
0.02275373600423336,
0.003204792272299528,
-0.012980706058442593,
-0.0011379752540960908,
0.024438343942165375,
0.004996129777282476,
0.03523829206824303,
-0.01669607311487198,
0.0014812428271397948,
0.04340748116374016,
-0.013476857915520668,
0.054045893251895905,
0.012888398952782154,
-0.03713059052824974,
-0.006819197908043861,
-0.0022370084188878536,
0.020226825028657913,
0.008036499843001366,
0.023157579824328423,
0.0036432514898478985,
-0.01789606735110283,
-0.04661515727639198,
-0.0024504689499735832,
0.032376766204833984,
0.0016355690313503146,
-0.026746025308966637,
0.004849014803767204,
0.04832284152507782,
-0.04216133430600166,
0.03170754015445709,
-0.025638338178396225,
0.04823053628206253,
0.009721106849610806,
0.024438343942165375,
-0.034799832850694656,
-0.020538361743092537,
0.024876803159713745,
-0.034661371260881424,
-0.02050374634563923,
0.030115239322185516,
-0.04324594512581825,
-0.017284531146287918,
-0.01563454046845436,
0.010205719619989395,
0.0024778726510703564,
0.004093249328434467,
-0.03839981555938721,
-0.014780697412788868,
0.035422906279563904,
-0.0665535256266594,
0.001595184556208551,
-0.0026754678692668676,
0.03560752049088478,
-0.017665298655629158,
0.022707583382725716,
-0.019661443307995796,
0.01625761389732361,
0.023099888116121292,
0.023434501141309738,
-0.0424613319337368,
0.01669607311487198,
-0.018726833164691925,
0.0011704270727932453,
-0.013753779232501984,
-0.048184383660554886,
0.023203734308481216,
-0.056861262768507004,
0.036322902888059616,
0.015853770077228546,
-0.028384478762745857,
0.002567295217886567,
0.01566915586590767,
-0.0013283590087667108,
0.0027533520478755236,
-0.00156489631626755,
-0.0348459854722023,
0.021369127556681633,
0.03027677722275257,
0.034453678876161575,
-0.024992186576128006,
-0.018196064978837967,
0.019996056333184242,
0.036415208131074905,
-0.008249959908425808,
0.03454598784446716,
-0.009513415396213531,
-0.01704222522675991,
-0.029861394315958023,
-0.012115325778722763,
-0.022038355469703674,
0.00063966034213081,
0.014423007145524025,
0.01022302731871605,
0.021946048364043236,
-0.022765275090932846,
0.006178816314786673,
0.038145970553159714,
0.045115165412425995,
0.026722947135567665,
0.04553055018186569,
-0.009513415396213531,
0.053722817450761795,
-0.03408445045351982,
0.0036634437274187803,
0.01540377177298069,
-0.034684449434280396,
-0.01654607430100441,
-0.021207589656114578,
-0.04497670382261276,
-0.005671126302331686,
-0.019776826724410057,
-0.013949932530522346,
0.015426848083734512,
0.0035855595488101244,
0.0011408599093556404,
0.007649962790310383,
-0.019938364624977112,
-0.005313436035066843,
-0.015749923884868622,
-0.03602290153503418,
-0.002408642088994384,
-0.06304585188627243,
0.02208450809121132,
-0.014549929648637772,
0.0033749835565686226,
0.011053793132305145,
-0.015173003077507019,
-0.0228460431098938,
-0.017065301537513733,
-0.004843245726078749,
-0.03069216012954712,
-0.00834803655743599,
0.0022947003599256277,
-0.010396103374660015,
0.026261411607265472,
-0.008567266166210175,
-0.00021219848713371903,
-0.014596083201467991,
0.037292126566171646,
-0.04776899889111519,
0.017549915239214897,
-0.009455723688006401,
0.034799832850694656,
-0.04172287508845329,
0.011849942617118359,
0.0001323310862062499,
0.01563454046845436,
-0.012334555387496948,
-0.017665298655629158,
-0.008324959315359592,
0.015473001636564732,
0.003799020079895854,
-0.011417252011597157,
-0.0037845971528440714,
0.0020105671137571335,
-0.02278835140168667,
-0.03500752151012421,
0.003599982475861907,
-0.01041341107338667,
-0.006790351588279009,
-0.047861307859420776,
0.027599865570664406,
-0.05441512167453766,
-0.005965355783700943,
0.02741525135934353,
-0.04405363276600838,
0.0688612088561058,
0.015611463226377964,
-0.011988403275609016,
-0.003617290174588561,
0.0009050436783581972,
0.012219171971082687,
-0.012819169089198112,
-0.026469102129340172,
0.002079797675833106,
0.028338324278593063,
-0.02418449893593788,
0.026261411607265472,
-0.034361373633146286,
0.005382666364312172,
-0.03103831224143505,
0.05432281270623207,
0.006461507175117731,
0.005019206553697586,
0.03863058239221573,
0.008746111765503883,
-0.04823053628206253,
-0.011907634325325489,
0.03461521863937378,
-0.019396059215068817,
-0.029630625620484352,
0.005697087850421667,
-0.027899865061044693,
-0.006178816314786673,
-0.017988374456763268,
0.0012843688018620014,
-0.003054792992770672,
0.015484540723264217,
-0.028430631384253502,
-0.025822952389717102,
-0.007759578060358763,
-0.017146071419119835,
0.027484482154250145,
0.010655717924237251,
0.016188383102416992,
-0.026953715831041336,
0.004699015524238348,
-0.0063692000694572926,
-0.0012944649206474423,
-0.0035163292195647955,
0.019246060401201248,
-0.06281507760286331,
-0.021484510973095894,
0.002320661908015609,
-0.01715760864317417,
0.01599222980439663,
-0.022592198103666306,
-0.023007581010460854,
-0.00805380754172802,
-0.011896096169948578,
-0.005342281889170408,
0.014319161884486675,
0.003588444087654352,
-0.03574598208069801,
0.011498020961880684,
0.017399916425347328,
0.022672967985272408,
-0.017792221158742905,
0.0021129704546183348,
-0.014896081760525703,
-0.0078634237870574,
-0.009011494927108288,
-0.005555742420256138,
0.018519140779972076,
-0.003294214839115739,
-0.0480920746922493,
0.02105759084224701,
-0.01821914315223694,
-0.027669096365571022,
-0.017596067860722542,
0.024507572874426842,
-0.02656140923500061,
-0.009726876392960548,
-0.018553756177425385,
0.025292186066508293,
-0.018899908289313316,
-0.0028759476263076067,
-0.0024995070416480303,
0.01944221369922161,
0.0018692216835916042,
0.06964581459760666,
0.07998422533273697,
-0.02026144042611122,
0.02404603734612465,
0.0012151383562013507,
0.010834562592208385,
-0.012611477635800838,
0.027392175048589706,
0.01724991574883461,
0.011976865120232105,
0.003095177235081792,
0.0068365056067705154,
0.07675347477197647,
0.03408445045351982,
-0.018080681562423706,
-0.033899836242198944,
-0.023584501817822456,
0.007834577932953835,
-0.012461477890610695,
-0.03634597733616829,
-0.008267267607152462,
0.02513064816594124,
-0.013130705803632736,
0.023065272718667984,
-0.01616530679166317,
-0.040430571883916855,
0.01628069020807743,
0.007113426923751831,
0.0005235551507212222,
0.033807527273893356,
-0.008509574458003044,
-0.011388406157493591,
-0.018669139593839645,
-0.001441579544916749,
-0.014503776095807552,
-0.010978792794048786,
0.0165114589035511,
0.010280719958245754,
-0.008653804659843445,
-0.0023076811339706182,
-0.016788380220532417,
-0.019072985276579857,
0.028661400079727173,
0.0330229178071022,
0.008832649327814579,
0.004156710579991341,
0.021184513345360756,
-0.013753779232501984,
-0.04234594851732254,
-0.021276820451021194,
0.038238275796175,
0.04398440197110176,
0.02082682214677334,
-0.013257628306746483,
0.0074018873274326324,
-0.03856135159730911,
-0.010390334762632847,
0.029215242713689804,
-0.009438415989279747,
0.011838404461741447,
0.014676852151751518,
0.04518439620733261,
-0.0010586486896499991,
0.016580689698457718,
-0.014780697412788868,
-0.009686491452157497,
0.015646077692508698,
0.036622900515794754,
-0.021634511649608612,
0.07956884801387787,
-0.011440329253673553,
-0.0014545603189617395,
-0.004422094207257032,
-0.01584223099052906,
-0.01850760355591774,
-0.005818241275846958,
-0.03733827918767929,
0.02483064867556095,
-0.04234594851732254,
-0.01772299036383629,
-0.015046081505715847,
-0.017503760755062103,
0.023146042600274086,
-0.038053661584854126,
-0.0004723534802906215,
0.024299882352352142,
-0.009923028759658337,
0.03189215436577797,
0.054922811686992645,
0.014665313996374607,
0.006923043634742498,
-0.020111441612243652,
-0.012761476449668407,
0.007701885886490345,
-0.029976777732372284,
0.008526882156729698,
-0.01704222522675991,
-0.01637299731373787,
-0.007413425482809544,
-0.0008653804543428123,
-0.035192135721445084,
-0.0185422170907259,
-0.03410752862691879,
0.013996086083352566,
0.0037528665270656347,
-0.004174018278717995,
0.022834504023194313,
-0.01742299273610115,
0.04375363513827324,
0.017884528264403343,
-0.02656140923500061,
0.022765275090932846,
-0.016003768891096115,
-0.012311479076743126,
0.016061460599303246,
0.0062595852650702,
0.020215285941958427,
-0.001909606158733368,
-0.023261426016688347,
0.028038326650857925,
0.016730688512325287,
0.0013507145922631025,
-0.023561423644423485,
0.0017019148217514157,
0.003548059845343232,
-0.002537006977945566,
-0.005826894659548998,
-0.014353776350617409,
-0.01414608582854271,
0.018703754991292953,
-0.030346006155014038,
-0.0006140595069155097,
-0.010828793980181217,
0.01540377177298069,
-0.016465304419398308,
0.009467261843383312,
0.0034067141823470592,
0.038238275796175,
0.024622958153486252,
-0.06378430873155594,
-0.025222955271601677,
-0.004915360826998949,
-0.026746025308966637,
0.025638338178396225,
0.009386492893099785,
-0.030415236949920654,
-0.024207575246691704,
0.02831524796783924,
-0.01964990422129631,
0.0004568487638607621,
-0.025615260004997253,
0.02336527220904827,
0.009144186973571777,
-0.006611506454646587,
-0.009721106849610806,
-0.015738384798169136,
-0.057415105402469635,
0.0011603309540078044,
0.028338324278593063,
-0.004531709011644125,
0.020342208445072174,
-0.01637299731373787,
0.061892006546258926,
0.014526852406561375,
0.019511444494128227,
-0.014296084642410278,
0.037499818950891495,
-0.047630537301301956,
-0.006398045923560858,
0.022765275090932846,
0.007828808389604092,
-0.007534578908234835,
0.014896081760525703,
-0.02905370481312275,
-0.048599764704704285,
0.005134590435773134,
-0.03574598208069801,
0.004877861123532057,
0.016649918630719185,
0.023296041414141655,
0.020169133320450783,
0.01042494922876358,
0.01550761703401804,
-0.023215271532535553,
0.019615288823843002,
-0.003380752867087722,
-0.02029605582356453,
0.013696087524294853,
-0.024115268141031265,
0.01780376024544239,
-0.054368969053030014,
-0.02817678637802601,
0.006928812712430954,
-0.005994201637804508,
-0.035538289695978165,
0.011001870036125183,
0.006755736656486988,
0.007626886013895273,
0.015415309928357601,
-0.03475367650389671,
0.0438690185546875,
-0.003282676450908184,
-0.007303810678422451,
-0.010874947533011436,
-0.003005754668265581,
-0.033692143857479095,
0.03646136075258255,
-0.05963047966361046,
-0.014330700039863586,
0.008249959908425808,
-0.009951874613761902,
-0.0342690646648407,
0.046661313623189926,
0.005310551263391972,
-0.014711467549204826,
-0.017319146543741226,
0.0276460200548172,
-0.012230710126459599,
0.019372982904314995,
-0.021830663084983826,
-0.04190748929977417,
0.008019192144274712,
0.0006656217738054693,
-0.024853726848959923,
0.01247301697731018,
0.033692143857479095,
0.02258066087961197,
0.006074970588088036,
0.009242262691259384,
0.008515343070030212,
-0.01915375329554081,
-0.019903749227523804,
-0.016949918121099472,
0.004549016244709492,
-0.014549929648637772,
-0.01970759779214859,
0.002128835767507553,
-0.03143061697483063,
-0.027738327160477638,
0.0480920746922493,
-0.011965326964855194,
-0.01219609472900629,
-0.03558444231748581,
-0.015311464667320251,
-0.005567280575633049,
0.04594593122601509,
0.012380708940327168,
-0.009946106001734734,
-0.02896139770746231,
0.02667679451406002,
-0.011907634325325489,
0.00775380851700902,
0.017699914053082466,
0.00863649696111679,
0.01051148772239685,
0.016857611015439034,
0.0003066691861022264,
0.006594198755919933,
0.03530752286314964,
0.04841515049338341,
0.03415368124842644,
-0.005074013955891132,
-0.007234580349177122,
-0.006628814153373241,
-0.013788394629955292,
0.016038384288549423,
0.028107555583119392,
0.009905721060931683,
-0.016326844692230225,
0.0004236758395563811,
-0.024553727358579636,
-0.0036432514898478985,
-0.012276863679289818,
-0.028915245085954666,
0.020099902525544167,
0.04356902092695236,
0.02644602581858635,
-0.00336056062951684,
0.0061615086160600185,
0.011896096169948578,
0.0019038369646295905,
0.018092220649123192,
-0.014480698853731155,
0.024092191830277443,
0.003014408517628908,
-0.014896081760525703,
0.03816904500126839,
0.00734996423125267,
-0.01871529407799244,
-0.00917880143970251,
0.02711525373160839,
0.034338295459747314,
0.06641506403684616,
-0.03048446774482727,
0.025938335806131363,
0.02623833529651165,
0.0019918172620236874,
-0.04613054543733597,
-0.0012295613996684551,
-0.009432646445930004,
0.053815122693777084,
-0.053168974816799164,
0.000859611202031374,
0.04682284966111183,
0.015611463226377964,
-0.031638309359550476,
-0.028246017172932625,
0.010101874358952045,
0.013857625424861908,
0.0013413396663963795,
-0.047861307859420776,
0.03745366632938385,
-0.022003740072250366,
-0.01599222980439663,
-0.012588400393724442,
0.04823053628206253,
0.017399916425347328,
0.010978792794048786,
0.014930697157979012,
-0.016234537586569786,
-0.0008487939485348761,
-0.01453839149326086,
0.03339214622974396,
0.021299896761775017,
-0.02861524559557438,
-0.010419180616736412,
-0.04038441926240921,
0.027715250849723816,
0.007153811398893595,
-0.028684476390480995,
-0.020549900829792023,
0.0025716221425682306,
0.06544584035873413,
0.043061330914497375,
-0.026261411607265472,
-0.02225758507847786,
0.0004932668525725603,
-0.030876774340867996,
-0.026076797395944595,
-0.0075057330541312695,
0.027899865061044693,
0.05833818018436432,
-0.012323017232120037,
0.002483641728758812,
0.01894606277346611,
0.007534578908234835,
-0.03419983386993408,
-0.000007115725566109177,
0.027807557955384254,
0.003046139143407345,
0.038376737385988235,
-0.0557074211537838,
0.025730645284056664,
0.015680693089962006,
-0.01709991693496704,
0.03461521863937378,
0.016522996127605438,
-0.035953670740127563,
-0.03498444706201553,
-0.023088349029421806,
-0.011549944058060646,
0.0003290248569101095,
-0.007119196467101574,
-0.011065331287682056,
0.019696058705449104,
0.030184470117092133,
0.022684505209326744,
0.00023094839707482606,
0.000314962409902364,
-0.03692289814352989,
0.010326873511075974,
0.015911461785435677,
0.036253672093153,
-0.0001391820260323584,
-0.022003740072250366,
-0.03943827003240585,
-0.021738355979323387,
0.02591525949537754,
-0.017111456021666527,
0.04541516676545143,
-0.03844596818089485,
-0.018311450257897377,
-0.022857582196593285,
0.011474944651126862,
0.017619146034121513,
0.02222296968102455,
-0.00815765280276537,
-0.017180686816573143,
-0.004061518702656031,
-0.007073042914271355,
-0.0029538318049162626,
0.01124417595565319,
0.011826866306364536,
0.051415134221315384,
0.021530665457248688,
0.03613828495144844,
0.025176800787448883,
0.024415265768766403,
-0.00006440774450311437,
-0.026492180302739143,
0.0070038121193647385,
0.007632655557245016,
-0.007044196594506502,
0.025430645793676376,
-0.038815196603536606,
0.007759578060358763,
-0.0010802831966429949,
0.026284487918019295,
0.051968980580568314,
0.007251888047903776,
0.017976835370063782,
0.015369156375527382,
0.009911490604281425,
-0.006819197908043861,
-0.004981706850230694,
0.016326844692230225,
-0.010067258961498737,
-0.0024389305617660284,
0.004119210876524448,
-0.033484455198049545,
0.003199022961780429,
-0.041861336678266525,
-0.010303796268999577,
0.01333839725703001,
0.01045379601418972,
-0.02981523983180523,
-0.002545660827308893,
0.016130691394209862,
-0.009957644157111645,
-0.026930639520287514,
0.01224224828183651,
-0.019142214208841324,
-0.015276849269866943,
-0.02296142652630806,
-0.02029605582356453,
-0.001785568310879171,
0.004223056603223085,
0.008792265318334103,
0.000221753740333952,
0.03364599123597145,
0.021184513345360756,
-0.007528809830546379,
-0.001527396496385336,
0.02556910738348961,
-0.013592242263257504,
-0.04405363276600838,
-0.019315291196107864,
0.032076768577098846,
-0.003905750345438719,
-0.03962288424372673,
-0.006905735936015844,
-0.00590189453214407,
-0.035192135721445084,
0.02290373481810093,
0.011215330101549625,
-0.040338266640901566,
0.008648035116493702,
0.023526810109615326,
-0.008907649666070938,
0.001556242466904223,
0.011723020114004612,
-0.007546117529273033,
-0.016857611015439034,
-0.035976748913526535,
-0.003706712741404772,
0.014249931089580059,
-0.003940365742892027,
0.027692174538969994,
-0.011780711822211742,
0.056215111166238785,
-0.0069345817901194096,
0.015553770586848259,
0.00887303426861763,
-0.012761476449668407,
-0.0006162229692563415,
0.008532650768756866,
-0.02096528373658657,
-0.013984547927975655,
-0.0035769056994467974,
-0.01839221827685833,
0.01932683028280735,
0.009524953551590443,
0.0226383525878191,
0.009149955585598946,
0.017284531146287918,
-0.01763068325817585,
-0.013199936598539352,
-0.01947682909667492,
0.008573035709559917,
0.04855361208319664,
-0.029538318514823914,
-0.027669096365571022,
0.058199718594551086,
0.02720756083726883,
0.0015605693915858865,
0.011238407343626022,
-0.0036692130379378796,
0.001136532984673977,
-0.016038384288549423,
-0.005157667212188244,
0.01727299392223358,
0.03362291306257248,
-0.00840572826564312,
0.02170374058187008,
0.014746082946658134,
-0.01997298002243042,
-0.014007624238729477,
-0.015922999009490013,
-0.0039374809712171555,
0.017169147729873657,
0.019938364624977112,
-0.018796062096953392,
-0.006859582383185625,
-0.010349949821829796,
0.016026845201849937,
0.013280704617500305,
0.03376137465238571,
-0.013373012654483318,
0.020861437544226646,
0.01949990540742874,
-0.005290358792990446,
0.0056740110740065575,
-0.000010828523045347538,
-0.0011408599093556404,
-0.01550761703401804,
-0.037292126566171646,
-0.0274383295327425,
-0.009455723688006401,
-0.023907575756311417,
0.003349022241309285,
-0.008999956771731377,
-0.027507558465003967,
0.01003264356404543,
-0.021969124674797058,
-0.013949932530522346,
0.003282676450908184,
-0.010638410225510597,
-0.002489411039277911,
0.009784568101167679,
-0.02614602819085121,
0.00037535876617766917,
0.022730659693479538,
-0.0034124834928661585,
0.011849942617118359,
0.019280675798654556,
0.012599939480423927,
0.007955730892717838,
0.008186498656868935,
0.016430689021945,
-0.011446098797023296,
0.004730746150016785,
-0.0394844226539135,
-0.0005585309700109065,
-0.031199848279356956,
0.011653789319097996,
0.019730674102902412,
0.005385550670325756,
-0.003943250048905611,
-0.013557626865804195,
0.009409570135176182,
0.020388362929224968,
0.017665298655629158,
-0.00290335132740438,
-0.0018216257449239492,
0.013984547927975655,
0.01300378330051899,
-0.013292243704199791,
-0.03719982132315636,
0.022072970867156982,
-0.016119152307510376,
0.019903749227523804,
0.008809573017060757,
-0.00623650848865509,
-0.028246017172932625,
0.00815765280276537,
-0.02667679451406002,
-0.007909577339887619,
-0.021299896761775017,
0.015623001381754875,
-0.003349022241309285,
-0.020757591351866722,
0.04753823205828667,
0.030461391434073448,
0.000572593358810991,
0.008319190703332424,
-0.009149955585598946,
0.023157579824328423,
0.030092163011431694,
0.03789212554693222,
0.011076869443058968,
0.027692174538969994,
-0.00863649696111679,
-0.002489411039277911,
-0.02404603734612465,
0.02012297883629799,
-0.04179210588335991,
-0.018253758549690247,
0.020746054127812386,
0.01985759660601616,
-0.04049980267882347,
-0.013603780418634415,
0.028592169284820557,
0.014249931089580059,
-0.002587487455457449,
0.017907606437802315,
-0.020399902015924454,
0.019015291705727577,
-0.015761462971568108,
-0.013615318574011326,
-0.006121124140918255,
0.03219215199351311,
0.026284487918019295,
0.03318445384502411,
0.01663838140666485,
-0.039992112666368484,
0.05072282999753952,
0.003109600394964218,
0.031730614602565765,
-0.007771116215735674,
0.0054663196206092834,
-0.02720756083726883,
-0.010886485688388348,
-0.029861394315958023,
0.015599924139678478,
0.015323002822697163,
-0.03256138041615486,
-0.02633064240217209,
0.044907476752996445,
-0.004471132066100836,
-0.009853798896074295,
0.000049038222641684115,
0.0038220968563109636,
-0.00043160849600099027,
-0.015749923884868622,
-0.006467276252806187,
0.02199220098555088,
-0.01339608896523714,
0.0006634583114646375,
-0.015484540723264217,
-0.011596097610890865,
0.015288387425243855,
0.006882659159600735,
-0.00534516666084528,
0.01055764127522707,
0.0276460200548172,
-0.041538260877132416,
-0.10061489790678024,
0.042599793523550034,
0.02723063714802265,
-0.008613419719040394,
-0.009617261588573456,
0.0018908561905846,
-0.006490353029221296,
0.03579213470220566,
-0.07001504302024841,
0.011261483654379845,
0.03454598784446716,
0.017030686140060425,
-0.017584530636668205,
-0.012380708940327168,
0.025176800787448883,
0.0130153214558959,
-0.0028961398638784885,
0.02324988692998886,
-0.0500766821205616,
-0.015253772027790546,
0.01675376482307911,
-0.030992157757282257,
0.017434531822800636,
0.04133056849241257,
0.002640852704644203,
-0.004802861250936985,
-0.029007552191615105,
-0.035422906279563904,
0.036299824714660645,
-0.026192180812358856,
0.004929783754050732,
-0.015565309673547745,
-0.024438343942165375,
-0.01941913738846779,
0.01508069597184658,
0.018022989854216576,
0.01085187029093504,
0.010194181464612484,
0.03126908093690872,
0.014111470431089401,
-0.022742196917533875,
0.023122964426875114,
0.03920750319957733,
0.02427680604159832,
-0.007188426796346903,
-0.004468247760087252,
0.007574963383376598,
-0.0051807439886033535,
-0.009628799743950367,
0.004517285618931055,
0.00017100277182180434,
-0.037245973944664,
0.005313436035066843,
0.02181912586092949,
-0.0324459969997406,
0.018726833164691925,
0.014907619915902615,
0.005151898134499788,
-0.018784524872899055,
-0.0038538274820894003,
-0.04019980505108833,
-0.013199936598539352,
-0.011734558269381523,
-0.0046067084185779095,
-0.01645376719534397,
-0.013799932785332203,
0.009265339933335781,
-0.0015447040786966681,
0.0008718707831576467,
0.006323046516627073,
-0.0007903808145783842,
-0.021519126370549202,
-0.0014242719626054168,
-0.004303825553506613,
0.01885375566780567,
-0.027622943744063377,
0.040661342442035675,
-0.02202681638300419,
-0.013084552250802517,
-0.024761417880654335,
-0.00854995846748352,
-0.013661472126841545,
-0.00013539598148781806,
-0.020319132134318352,
0.002136047463864088,
0.02012297883629799,
0.014065316878259182,
-0.000982927973382175,
0.028430631384253502,
-0.0020971051417291164,
0.00912110973149538,
-0.0342690646648407,
-0.003998057451099157,
0.005290358792990446,
0.026169104501605034,
-0.005437473766505718,
-0.024899879470467567,
-0.0015490310033783317,
-0.026192180812358856,
-0.01506915781646967,
-0.02568449079990387,
-0.029099859297275543,
0.002779313363134861,
-0.01388070173561573,
-0.011192253790795803,
-0.0026422948576509953,
-0.0007968711433932185,
0.001375954831019044,
0.0250383410602808,
-0.02416142076253891,
0.006109585985541344,
0.007448040880262852,
0.0012180230114609003,
0.029215242713689804,
0.029584472998976707,
0.008440343663096428,
-0.0034499831963330507,
0.00840572826564312,
0.010551871731877327,
0.0025644106790423393,
-0.021092206239700317,
0.014376853592693806,
-0.020365286618471146,
-0.011873019859194756,
0.0356767512857914,
-0.019222984090447426,
-0.0260306429117918,
0.0001602756674401462,
-0.025892183184623718,
-0.01371916476637125,
0.02395373024046421,
-0.044353630393743515,
-0.002806717297062278,
-0.028384478762745857,
0.021599896252155304,
0.02723063714802265,
0.006871120538562536,
-0.02709217742085457,
0.014388391748070717,
-0.008451881818473339,
-0.007984576746821404,
-0.009346108883619308,
0.02204989269375801,
-0.029238320887088776,
0.050492063164711,
0.020515285432338715,
0.022649889811873436,
0.027022946625947952,
0.015092235058546066,
0.004176903050392866,
0.033138301223516464,
-0.018761448562145233,
0.005503819324076176,
0.0101191820576787,
-0.05076898634433746,
-0.010649948380887508,
0.0394844226539135,
0.02787678875029087,
0.003380752867087722,
0.017676837742328644,
0.005907663609832525,
-0.04199979826807976,
-0.014549929648637772,
-0.007719193585216999,
-0.0047365156933665276,
-0.0015490310033783317,
0.0138230100274086,
0.10975331813097,
-0.03789212554693222,
0.005789394956082106,
0.008515343070030212,
0.004860553424805403,
-0.008780727162957191,
0.024138344451785088,
0.01789606735110283,
0.017411453649401665,
-0.0070038121193647385,
0.01686914823949337,
0.018530679866671562,
0.040638264268636703,
0.028799859806895256,
0.05279974639415741,
-0.021011436358094215,
0.007765347138047218,
0.032607533037662506,
-0.0031672923360019922,
0.005451896693557501,
0.024553727358579636,
-0.00390863511711359,
-0.03447675704956055,
0.02951524220407009,
-0.020111441612243652,
-0.011584559455513954,
0.0014091278426349163,
-0.0012014365056529641,
-0.01349993422627449,
0.023411424830555916,
0.01628069020807743,
-0.006582660600543022,
0.0012475901748985052,
-0.03320753201842308,
-0.001135090715251863,
-0.020399902015924454,
-0.021576818078756332,
-0.01069033332169056,
0.01218455657362938,
-0.016119152307510376,
0.020769130438566208,
-0.0017062417464330792,
-0.030069084838032722,
0.016534535214304924,
0.03909211978316307,
-0.017411453649401665,
-0.028430631384253502,
-0.012703784741461277,
0.005723049398511648,
-0.04116903245449066,
0.0252460315823555,
0.009242262691259384,
0.01789606735110283,
-0.007199964951723814,
-0.017930682748556137,
-0.035122908651828766,
-0.009594184346497059,
-0.012784553691744804,
-0.029792163521051407,
-0.029215242713689804,
-0.0065595838241279125,
0.024576803669333458,
0.027299867942929268,
0.012484555132687092,
-0.030092163011431694
] | 2025-01-07 | 1 | 39761676 | [
"tumour cell killing",
"Raji cells",
"high CAR expression",
"marked tumour regression",
"leukaemic cells",
"malignant tumours",
"CAR",
"strong anti-tumour efficacy",
"treated mice",
"mRNA-LNP CAR-T cells",
"CAR-T safety",
"increased cytokine secretion",
"Therapeutic efficacy",
"transformative potential",
"Raji engraftment",
"CAR-T products",
"efficacy",
"viral vector-based CAR-T cells",
"safety",
"mRNA",
"LNPs",
"clinical cancer immunotherapy",
"efficient delivery",
"lipid nanoparticles",
"insertional mutagenesis",
"secondary tumour formation-remain challenges",
"traditional methods",
"Raji",
"a non-viral, effective CAR-T engineering platform",
"costs"
] | [
"CAR‐T cells",
"Leukaemia eradication",
"mRNA‐LNP",
"non‐viral transfection"
] | 0 | 10.1111/bjh.19988 | [
"Chen",
"Ren",
"Li",
"Shu",
"Wu",
"Huang",
"Wang",
"Hu",
"Mei"
] | [
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.",
"Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.\nHubei Clinical Medical Center of Cell Therapy for Neoplastic Disease, Wuhan, China.\nHubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
] | [
"39761676"
] | [] | 9.895608 | 3.348808 |
39759518 | 74 | Targeting CEA in metastatic triple negative breast cancer with image-guided radiation followed by Fab-mediated chimeric antigen receptor (CAR) T-cell therapy. | Although CAR-T cell therapy has limited efficacy against solid tumors, it has been hypothesized that prior treatment with Image-Guided Radiation Therapy (IGRT) would increase CAR-T cell tumor infiltration, leading to improved antigen specific expansion of CAR-T cells.
To test this hypothesis in a metastatic triple negative breast cancer (TNBC) model, we engineered two anti-CEA single-chain Fab (scFab) CAR-T cells with signaling domains from CD28zeta and 4-1BBzeta, and tested them
The anti-CEA scFab CAR-T cells generated from three different human donors demonstrated robust
These findings demonstrate that the combination of IGRT and anti-CEA scFab CAR-T therapy induces a strong antitumor response, effectively targeting both the primary tumor and distant metastatic lesions in the lungs, thus demonstrating that IGRT enhances CAR-T cell infiltration, persistence, and overall efficacy within both primary and metastatic lesions. | [
0.044950708746910095,
-0.021699918434023857,
0.030918998643755913,
0.04187357798218727,
-0.0736541748046875,
-0.023780057206749916,
-0.0051234206184744835,
0.01481945626437664,
-0.026290996000170708,
-0.019767479971051216,
0.012739316560328007,
0.00010433392890263349,
-0.02769416570663452,
-0.006757376715540886,
0.01968132145702839,
0.021786076948046684,
0.036531683057546616,
-0.01664111763238907,
-0.018031978979706764,
0.04317828267812729,
0.023644663393497467,
-0.007680515293031931,
-0.00030790528398938477,
-0.0378117673099041,
-0.05056339502334595,
-0.023767748847603798,
0.021724535152316093,
0.00030598207376897335,
-0.022093789651989937,
-0.012800859287381172,
0.008160547353327274,
-0.023250792175531387,
-0.03197753056883812,
-0.06951851397752762,
-0.04263670742511749,
0.036605533212423325,
0.019632086157798767,
0.025970973074436188,
-0.008037462830543518,
-0.0044556837528944016,
0.02840805985033512,
0.01799505390226841,
-0.01702268049120903,
0.08054694533348083,
-0.06833689659833908,
-0.007163557689636946,
-0.00593886012211442,
-0.05765309929847717,
-0.010720719583332539,
0.017945820465683937,
-0.009206771850585938,
0.00005062839773017913,
-0.02828497439622879,
0.014905615709722042,
-0.04246438667178154,
0.0038279492873698473,
-0.02661101706326008,
0.004363369662314653,
-0.019705938175320625,
0.011009969748556614,
-0.005634224507957697,
-0.023140015080571175,
0.04519687965512276,
-0.017268851399421692,
-0.048766348510980606,
-0.012511609122157097,
-0.016788819804787636,
-0.03818102553486824,
0.028752699494361877,
-0.02816189080476761,
-0.004735702648758888,
-0.014745605178177357,
-0.01934899017214775,
0.025133995339274406,
0.06109948456287384,
-0.017527330666780472,
0.02570018731057644,
0.029688145965337753,
0.03094361536204815,
-0.03975651413202286,
0.05322203412652016,
-0.019496692344546318,
0.023927759379148483,
-0.03461155295372009,
-0.020309055224061012,
-0.006363504100590944,
0.0006946619832888246,
-0.042168982326984406,
-0.044876858592033386,
0.002986354287713766,
-0.0326421894133091,
0.027423378080129623,
-0.03687632083892822,
0.015828754752874374,
0.004480300471186638,
0.05085879936814308,
0.009680649265646935,
-0.10014210641384125,
0.039313409477472305,
0.03256833925843239,
0.017465787008404732,
-0.01961977779865265,
-0.017527330666780472,
-0.0052095805294811726,
0.0647428035736084,
0.016862669959664345,
-0.025146303698420525,
0.01269008219242096,
0.04684622213244438,
-0.006095793563872576,
0.06607212871313095,
-0.057899270206689835,
0.009200617671012878,
0.04603385925292969,
-0.027989570051431656,
-0.037122491747140884,
-0.03581778705120087,
-0.0009169846307486296,
-0.013957859948277473,
0.037245575338602066,
-0.02924503944814205,
0.043276749551296234,
0.0111699802801013,
-0.02848191186785698,
0.00860365480184555,
-0.03778715059161186,
0.06538285315036774,
-0.04640311375260353,
-0.02609405852854252,
-0.039781130850315094,
0.0469939224421978,
-0.021564524620771408,
0.03197753056883812,
0.02419854700565338,
-0.033306851983070374,
-0.01104074064642191,
-0.01126229390501976,
-0.008726739324629307,
-0.03695017099380493,
-0.008234398439526558,
-0.0033879196271300316,
0.004741856828331947,
-0.032716043293476105,
-0.025921739637851715,
-0.02976199798285961,
-0.05676688626408577,
-0.017231926321983337,
0.01433942373842001,
0.03431614860892296,
0.031608276069164276,
-0.05573297291994095,
0.02976199798285961,
0.051745012402534485,
-0.023595429956912994,
0.0020955251529812813,
-0.01896742731332779,
-0.02801418863236904,
0.042612090706825256,
-0.026832569390535355,
-0.05720999464392662,
0.010172990150749683,
-0.004175664857029915,
-0.02000134252011776,
0.01106535829603672,
0.007206637412309647,
0.0161857008934021,
0.00011279603495495394,
0.027989570051431656,
-0.08044847846031189,
0.001036223373375833,
-0.021921470761299133,
-0.05095726624131203,
-0.03347916901111603,
-0.030008167028427124,
-0.038033321499824524,
0.006837381981313229,
0.03820564225316048,
-0.0030309725552797318,
0.00718202069401741,
-0.007772829383611679,
-0.032986830919981,
0.03483310714364052,
0.01728115975856781,
0.020050575956702232,
-0.01966901309788227,
0.036334745585918427,
-0.006898924708366394,
0.022672289982438087,
-0.04992334917187691,
-0.017748882994055748,
-0.011366916820406914,
-0.014844072982668877,
0.06006557121872902,
0.040938131511211395,
-0.009797580540180206,
-0.0028232664335519075,
0.014277881011366844,
0.025774037465453148,
-0.013354742899537086,
-0.0034833108074963093,
0.056225311011075974,
0.02685718797147274,
-0.041258152574300766,
-0.004187973216176033,
-0.00857903715223074,
-0.03992883488535881,
-0.03202676400542259,
0.00009774694626685232,
-0.019275140017271042,
0.025527866557240486,
0.04381832480430603,
-0.01778580993413925,
-0.009428325109183788,
-0.004138739313930273,
-0.038993384689092636,
-0.009465250186622143,
-0.006052713841199875,
0.006658908445388079,
0.024875516071915627,
0.028851166367530823,
-0.015127168968319893,
-0.005920397117733955,
0.006369658280164003,
0.02071523666381836,
-0.022684600204229355,
0.004929561633616686,
0.029269656166434288,
-0.0061634904704988,
0.001680112793110311,
-0.052532754838466644,
-0.04194743186235428,
0.019447458907961845,
0.016616499051451683,
-0.03419306501746178,
-0.016001073643565178,
0.009477559477090836,
0.009280622936785221,
-0.017908893525600433,
0.06021327152848244,
-0.04603385925292969,
0.007532813120633364,
0.046501584351062775,
0.033749956637620926,
-0.024937057867646217,
-0.061394888907670975,
-0.02459242008626461,
-0.0001794351264834404,
-0.05287739634513855,
-0.012800859287381172,
0.0332576185464859,
-0.013490135781466961,
0.0042495159432291985,
-0.019459767267107964,
-0.035768553614616394,
0.02024751342833042,
0.036088574677705765,
0.0375409796833992,
0.005726538132876158,
-0.002269383054226637,
-0.04509841278195381,
0.006468126550316811,
0.01831507496535778,
-0.04438451677560806,
-0.05922859162092209,
-0.030278954654932022,
0.01209927350282669,
0.006911233067512512,
0.012431603856384754,
0.014425583183765411,
0.0032740659080445766,
-0.0037848693318665028,
0.035891640931367874,
0.04716624319553375,
-0.003243294544517994,
-0.029491210356354713,
0.01709653250873089,
-0.02012442797422409,
0.012314672581851482,
0.016665734350681305,
0.013994785025715828,
-0.017121149227023125,
-0.0007092783926054835,
-0.009237542748451233,
0.0020601381547749043,
-0.01424095593392849,
-0.018733564764261246,
0.016087234020233154,
-0.021515289321541786,
0.00652351463213563,
-0.017256543040275574,
0.023915451020002365,
-0.009256006218492985,
0.0057634636759757996,
0.015213328413665295,
-0.022118408232927322,
-0.0034156139008700848,
0.0021047566551715136,
-0.009797580540180206,
-0.03965804725885391,
0.037319429218769073,
-0.05228658765554428,
0.02971276268362999,
-0.019336681813001633,
-0.004055656958371401,
0.024481642991304398,
0.028900401666760445,
-0.020173661410808563,
-0.013416284695267677,
0.029589679092168808,
0.053960543125867844,
0.01565643586218357,
0.0030263569205999374,
-0.0015716439811512828,
0.010302229784429073,
-0.005560372956097126,
0.0013377821305766702,
0.015213328413665295,
-0.04623079672455788,
0.009409862570464611,
-0.034143831580877304,
-0.012874710373580456,
-0.005526524968445301,
-0.019176671281456947,
0.009600643999874592,
0.013219349086284637,
-0.0037725609727203846,
-0.010923810303211212,
-0.027817251160740852,
0.0024801664985716343,
-0.03596549108624458,
0.04711700975894928,
-0.002213994739577174,
0.0656290203332901,
-0.05445288494229317,
0.014327115379273891,
-0.0183273833245039,
-0.03756559640169144,
-0.05509292706847191,
0.001270854496397078,
-0.008099005557596684,
0.021650683134794235,
-0.004037193953990936,
-0.035054661333560944,
0.06301961094141006,
0.02744799666106701,
0.02887578494846821,
0.023250792175531387,
0.02270921692252159,
0.025650952011346817,
0.051941946148872375,
0.02976199798285961,
0.01662880927324295,
0.0401257686316967,
0.009594489820301533,
-0.01424095593392849,
-0.018068905919790268,
-0.0318298302590847,
-0.039190322160720825,
0.01851201243698597,
0.021453747525811195,
-0.02594635635614395,
0.04568922147154808,
0.0038433349691331387,
0.01857355423271656,
0.021146034821867943,
0.02570018731057644,
0.008142084814608097,
0.06154259294271469,
-0.03217446804046631,
-0.029097337275743484,
-0.012665465474128723,
0.027398761361837387,
0.007914377376437187,
0.003775638062506914,
-0.03574393689632416,
0.035177744925022125,
0.02459242008626461,
0.017576564103364944,
0.03214985132217407,
0.00352639053016901,
0.030845146626234055,
-0.04005191847681999,
0.01980440691113472,
-0.04797860607504845,
-0.018881266936659813,
-0.0003430999640841037,
0.03631012886762619,
-0.019816715270280838,
-0.05164654180407524,
0.021059874445199966,
-0.032986830919981,
-0.030992848798632622,
0.0017893508775159717,
-0.011373070999979973,
0.0046187713742256165,
0.07414651662111282,
0.008302095346152782,
0.02976199798285961,
0.032125234603881836,
0.017047297209501266,
-0.013120880350470543,
-0.026832569390535355,
-0.029294272884726524,
-0.036014724522829056,
0.038993384689092636,
-0.01446250919252634,
0.018536629155278206,
0.010696102865040302,
0.027546463534235954,
0.007840526290237904,
-0.05164654180407524,
-0.03586702421307564,
0.0372701920568943,
0.02057984285056591,
0.0006738913943991065,
-0.005021875724196434,
-0.026118675246834755,
0.02931889146566391,
-0.022943077608942986,
0.014893307350575924,
0.03527621552348137,
-0.03340531885623932,
0.04571383818984032,
-0.022807683795690536,
0.03448846936225891,
-0.01703498885035515,
0.04711700975894928,
-0.0018447391921654344,
-0.00611425656825304,
-0.05095726624131203,
0.019312065094709396,
0.04790475219488144,
0.009957591071724892,
0.002780186478048563,
0.005905011668801308,
0.042612090706825256,
0.0015339490491896868,
0.020469065755605698,
-0.07719902694225311,
0.05656994879245758,
-0.012776241637766361,
-0.01632109470665455,
0.020013650879263878,
-0.07404804974794388,
-0.0017662723548710346,
-0.005566527601331472,
0.00990220345556736,
0.024617036804556847,
-0.0438675582408905,
0.011896182782948017,
-0.01922590658068657,
0.0042002820409834385,
0.0033233000431209803,
0.02666025049984455,
-0.022696908563375473,
0.0006461972370743752,
-0.000021864449081476778,
-0.04007653519511223,
0.01966901309788227,
0.03047589212656021,
0.06498897820711136,
-0.031879063695669174,
0.020432140678167343,
-0.010105293244123459,
0.011139209382236004,
0.03658091649413109,
0.015016392804682255,
-0.011114591732621193,
0.00763743557035923,
-0.04401526227593422,
-0.008849824778735638,
0.003289451589807868,
-0.03333146870136261,
0.011994651518762112,
0.024506259709596634,
0.03214985132217407,
0.0029463516548275948,
-0.002280153101310134,
0.02374313212931156,
0.019533619284629822,
-0.03399612754583359,
-0.01740424521267414,
0.0023524656426161528,
-0.00808669626712799,
0.03360225632786751,
0.0455661341547966,
-0.01597645692527294,
-0.002801726572215557,
0.029491210356354713,
0.023029237985610962,
0.008209781721234322,
0.01456097699701786,
0.005960400216281414,
-0.012486991472542286,
-0.00844979751855135,
-0.03980574756860733,
0.021589141339063644,
-0.005197271704673767,
-0.01703498885035515,
0.03214985132217407,
0.010763799771666527,
0.019115129485726357,
0.022770758718252182,
-0.010763799771666527,
0.01878279820084572,
0.04822477325797081,
-0.004144893493503332,
0.05548680201172829,
0.000959295139182359,
0.009926820173859596,
0.02899886853992939,
-0.0038617977406829596,
0.02963891252875328,
0.0064619723707437515,
-0.009440633468329906,
-0.016727276146411896,
-0.03818102553486824,
0.025921739637851715,
0.020764470100402832,
-0.012474683113396168,
-0.0043849097564816475,
-0.009908357635140419,
-0.00809285044670105,
0.007815909571945667,
0.02899886853992939,
-0.03916570544242859,
-0.03539929911494255,
-0.02129373699426651,
-0.008511340245604515,
-0.04150432348251343,
-0.003972574137151241,
-0.032592955976724625,
0.004541843198239803,
0.022290727123618126,
-0.01824122481048107,
-0.021699918434023857,
-0.023829292505979538,
0.0346854031085968,
-0.02115834318101406,
-0.012191587127745152,
0.012394677847623825,
-0.002767878118902445,
0.00990220345556736,
-0.011206906288862228,
-0.018265841528773308,
0.007920531556010246,
0.00624657329171896,
-0.036113191395998,
0.022487662732601166,
-0.019902873784303665,
0.03488234058022499,
-0.03825487568974495,
0.01638263836503029,
0.010689948685467243,
0.04059349372982979,
-0.009311393834650517,
0.01922590658068657,
-0.05351743847131729,
-0.008209781721234322,
0.003987960051745176,
0.0004242592549417168,
-0.006314269732683897,
-0.000397719006286934,
-0.03729481250047684,
0.0021001410204917192,
0.029171189293265343,
0.004791090730577707,
-0.017059607431292534,
-0.02538016438484192,
0.04049502685666084,
-0.01129921991378069,
0.00031963683431968093,
0.0034063823986798525,
-0.0018155064899474382,
0.039387259632349014,
-0.012973178178071976,
-0.04428604990243912,
0.027103357017040253,
-0.0032032919116318226,
0.008295941166579723,
-0.03163289278745651,
-0.017367320135235786,
0.006806610617786646,
0.060804080218076706,
-0.0005965785239823163,
0.00553267914801836,
-0.02240150421857834,
-0.0194843839854002,
0.004720316734164953,
-0.008135930635035038,
0.016161084175109863,
0.012339289300143719,
0.02693103812634945,
-0.004486455116420984,
-0.02491244114935398,
0.006855844520032406,
0.0012346982257440686,
0.027275675907731056,
-0.028457295149564743,
0.026635633781552315,
0.011022278107702732,
-0.02147836424410343,
-0.04632926359772682,
-0.0452953465282917,
-0.023029237985610962,
0.013637837953865528,
0.019853640347719193,
-0.021244503557682037,
0.007655898574739695,
-0.012542380020022392,
0.03837795928120613,
0.024235472083091736,
-0.024223163723945618,
-0.0070650894194841385,
0.02808803878724575,
-0.014167104847729206,
-0.0001784735213732347,
0.0029832771979272366,
0.031608276069164276,
-0.012973178178071976,
-0.03296221047639847,
-0.022499971091747284,
-0.029368124902248383,
-0.010529937222599983,
-0.002980200108140707,
-0.015065626241266727,
-0.005117266438901424,
-0.00355100748129189,
0.019385917112231255,
0.03234678506851196,
0.000795438012573868,
0.011533081531524658,
-0.0050680325366556644,
0.04640311375260353,
-0.004326444119215012,
-0.05780080333352089,
0.00736049422994256,
-0.0015831831842660904,
-0.02796495333313942,
0.006111179478466511,
-0.01591491512954235,
0.05029260739684105,
0.011625396087765694,
-0.01517640333622694,
0.00030348190921358764,
0.012653157114982605,
0.0072497171349823475,
0.02199532277882099,
0.006123487837612629,
0.00880674459040165,
-0.04108583554625511,
-0.038033321499824524,
0.00785898882895708,
0.024038536474108696,
0.013133188709616661,
-0.017847351729869843,
0.02342311106622219,
-0.011280757375061512,
0.018462777137756348,
0.04120891913771629,
-0.02685718797147274,
0.04775705188512802,
0.0025093990843743086,
-0.023078471422195435,
-0.038550280034542084,
0.014905615709722042,
-0.03384842723608017,
-0.0006785070872865617,
0.0077543663792312145,
-0.001650879974476993,
0.10477010905742645,
-0.005172654986381531,
0.006714296992868185,
-0.0035787017550319433,
-0.006917387247085571,
0.03409459441900253,
-0.005800389219075441,
-0.008954446762800217,
-0.02641407959163189,
0.01662880927324295,
-0.02226611040532589,
0.001181617728434503,
-0.00009423709707334638,
-0.05164654180407524,
0.00423720758408308,
-0.004880327731370926,
-0.014930232428014278,
0.009206771850585938,
-0.006298884283751249,
-0.00042272068094462156,
-0.014536360278725624,
-0.030845146626234055,
-0.0034956191666424274,
-0.019767479971051216,
-0.037959471344947815,
-0.0038679519202560186,
0.0010669947369024158,
-0.03987960144877434,
-0.013330125249922276,
-0.011225368827581406,
0.014659445732831955,
0.0033048372715711594,
0.008412872441112995,
-0.013219349086284637,
0.040544260293245316,
-0.03347916901111603,
-0.011182288639247417,
-0.02971276268362999,
0.033356085419654846,
0.031115934252738953,
0.0021109108347445726,
-0.004409526940435171,
0.02077677845954895,
-0.021576832979917526,
0.0030063556041568518,
-0.0005242659826762974,
-0.030820529907941818,
0.03992883488535881,
0.0037017869763076305,
0.02666025049984455,
-0.027595698833465576,
0.009169845841825008,
0.004717239644378424,
-0.002863269066438079,
0.03429153189063072,
0.018105830997228622,
-0.019053585827350616,
0.01592722348868847,
0.000400796125177294,
-0.01107151247560978,
0.01495485007762909,
-0.06361041963100433,
-0.018216608092188835,
0.004043348133563995,
-0.025146303698420525,
0.02892501838505268,
-0.04770781844854355,
-0.030180487781763077,
-0.010566863231360912,
0.0036002416163682938,
0.05322203412652016,
-0.05204041674733162,
-0.0403965562582016,
0.03773791715502739,
-0.006000402849167585,
0.03178059309720993,
0.01987825706601143,
0.024973982945084572,
-0.0026217144913971424,
-0.034463852643966675,
0.013453210704028606,
0.009200617671012878,
0.026709485799074173,
-0.022303035482764244,
-0.00652351463213563,
-0.013293200172483921,
0.028703464195132256,
-0.0030017399694770575,
-0.01657957397401333,
-0.00037310196785256267,
-0.020284438505768776,
-0.026167910546064377,
-0.01793351210653782,
-0.023090779781341553,
-0.03456231951713562,
0.004126430954784155,
0.0038217948749661446,
0.025995591655373573,
-0.01022837869822979,
0.03293759375810623,
-0.027792634442448616,
-0.011656166985630989,
0.023989303037524223,
-0.019976725801825523,
0.01611185073852539,
0.023029237985610962,
-0.02208148129284382,
0.01307164691388607,
-0.015164094977080822,
0.03384842723608017,
0.0035079277586191893,
0.024678578600287437,
-0.005166500806808472,
0.024420101195573807,
-0.00558191305026412,
-0.01961977779865265,
-0.011219214648008347,
-0.00024040075368247926,
-0.014634828083217144,
-0.006412738002836704,
-0.008265170268714428,
0.04337522014975548,
-0.01585337147116661,
-0.009951436892151833,
-0.0033633026760071516,
0.05592990666627884,
0.014930232428014278,
-0.08748894929885864,
-0.011354608461260796,
0.027226442471146584,
-0.030377423390746117,
0.005960400216281414,
0.037122491747140884,
0.018302766606211662,
-0.02290615253150463,
0.004218744579702616,
-0.010671485215425491,
-0.0008377485210075974,
-0.02634022943675518,
0.0031571348663419485,
-0.02419854700565338,
-0.005455750972032547,
-0.0012246975675225258,
-0.02880193293094635,
-0.04696930572390556,
-0.002506321994587779,
0.025478633120656013,
-0.014253264293074608,
0.022992312908172607,
0.011188442818820477,
0.03830410912632942,
0.005409593693912029,
0.024063153192400932,
-0.027004890143871307,
-0.005440365057438612,
-0.015373339876532555,
-0.013551678508520126,
-0.021502980962395668,
0.03118978627026081,
0.0097421919927001,
0.04989873245358467,
-0.005120343528687954,
-0.034980807453393936,
0.027472613379359245,
0.0073297228664159775,
0.008492877706885338,
0.025232462212443352,
0.00007981304952409118,
-0.009274468757212162,
0.013317816890776157,
0.02369389869272709,
-0.03483310714364052,
0.00423720758408308,
-0.04354753717780113,
0.012997795827686787,
-0.012480837292969227,
-0.01966901309788227,
0.030697444453835487,
-0.03507927805185318,
-0.029269656166434288,
-0.015828754752874374,
-0.006301961373537779,
-0.003966419957578182,
-0.001202388433739543,
0.016333403065800667,
0.026881804689764977,
0.014991775155067444,
-0.04120891913771629,
0.026980271562933922,
0.0323714017868042,
-0.009785272181034088,
0.005231120157986879,
-0.01285009365528822,
-0.036211661994457245,
0.042168982326984406,
-0.041652027517557144,
-0.006868153344839811,
0.007532813120633364,
0.0032679117284715176,
-0.03564547002315521,
0.007175866048783064,
-0.0014324038056656718,
-0.017244234681129456,
-0.019139746204018593,
0.00006880269211251289,
0.0005592682864516973,
0.015484116040170193,
-0.027940336614847183,
-0.009052915498614311,
-0.0008069772156886756,
0.0021355280186980963,
-0.02951582707464695,
-0.016358021646738052,
0.005769617855548859,
0.01187772024422884,
0.008074387907981873,
-0.019053585827350616,
-0.0046987771056592464,
-0.01281316764652729,
-0.010160681791603565,
0.007625127211213112,
-0.03761483356356621,
-0.0014331730781123042,
-0.04098736494779587,
0.011957725510001183,
0.008665196597576141,
-0.03591625764966011,
0.019693629816174507,
-0.04746164754033089,
-0.006418892182409763,
-0.053812842816114426,
-0.0323714017868042,
-0.011139209382236004,
0.05346820503473282,
-0.003212523413822055,
0.0018447391921654344,
-0.03451308608055115,
0.05597914010286331,
-0.008905213326215744,
0.015397956594824791,
-0.05514216423034668,
-0.0013570141745731235,
0.011705401353538036,
0.03599010780453682,
-0.04357215389609337,
0.024321632459759712,
-0.024038536474108696,
0.07567276805639267,
-0.0070097013376653194,
0.004628003109246492,
-0.024186238646507263,
0.01883203350007534,
0.008025153540074825,
0.018352000042796135,
0.004317212849855423,
-0.029885083436965942,
0.026881804689764977,
0.002677102806046605,
-0.010529937222599983,
0.02408776991069317,
-0.013551678508520126,
-0.007255871780216694,
0.026118675246834755,
0.028900401666760445,
0.02446933463215828,
0.0014816379407420754,
-0.002887886017560959,
-0.012068502604961395,
-0.028826549649238586,
-0.0015301026869565248,
0.0005334973684512079,
-0.008923675864934921,
-0.015619509853422642,
-0.05489599332213402,
0.0009792965138331056,
0.02168761007487774,
0.029589679092168808,
-0.004003345500677824,
0.035177744925022125,
0.012314672581851482,
0.03766406700015068,
-0.0032679117284715176,
0.055043693631887436,
0.015077934600412846,
-0.018462777137756348,
-0.03581778705120087,
0.012068502604961395,
-0.040864281356334686,
0.05642224848270416,
-0.021662991493940353,
-0.01895511895418167,
0.016591882333159447,
-0.004683391191065311,
-0.008628271520137787,
-0.005480367690324783,
0.04088889807462692,
0.03741789609193802,
0.023004621267318726,
-0.07124170660972595,
0.0498494990170002,
0.019718246534466743,
-0.04083966463804245,
0.008320558816194534,
0.018007362261414528,
0.02666025049984455,
0.01838892698287964,
0.041061218827962875,
-0.06700757145881653,
-0.0032402174547314644,
-0.0020416753832250834,
0.020530609413981438,
0.030697444453835487,
-0.0227830670773983,
-0.01330550853163004,
-0.0046926224604249,
0.03591625764966011,
0.02912195399403572,
-0.02816189080476761,
-0.014253264293074608,
-0.0030678980983793736,
0.02749723009765148,
0.00687430752441287,
0.004224898759275675,
-0.01936129853129387,
0.011003815568983555,
-0.04711700975894928,
-0.02363235503435135,
-0.04322751611471176,
0.035694703459739685,
0.03010663576424122,
-0.04293211176991463,
-0.008492877706885338,
0.01760118082165718,
0.006277344189584255,
-0.051154203712940216,
-0.035177744925022125,
0.020284438505768776,
0.00030521280132234097,
-0.02174915187060833,
-0.01936129853129387,
0.012560843490064144,
0.033109914511442184,
0.026044825091958046,
-0.00593886012211442,
-0.009366782382130623,
-0.027669548988342285,
-0.0011331529822200537,
-0.020272130146622658,
-0.024063153192400932,
0.004375678487122059,
0.021835312247276306,
0.0025940202176570892,
0.017330393195152283,
0.04509841278195381,
0.01954592764377594,
-0.027226442471146584,
0.01909051276743412,
-0.02796495333313942,
0.008388255722820759,
-0.011797714978456497,
0.014634828083217144,
0.014376349747180939,
0.0005396516062319279,
-0.033109914511442184,
-0.02311539836227894,
0.02801418863236904,
-0.013662455603480339,
0.031017465516924858,
0.008437489159405231,
0.00821593590080738,
-0.04071657732129097,
-0.014487125910818577,
0.010603788308799267,
0.06050867587327957,
-0.0021309121511876583,
-0.01896742731332779,
0.017515022307634354,
0.001953977392986417,
0.04049502685666084,
0.010966889560222626,
0.01505331788212061,
0.04332598298788071,
0.0022586132399737835,
0.0028309591580182314,
-0.022573823109269142,
0.029860464856028557,
-0.0013700919225811958,
-0.01612415909767151,
-0.005141883622854948,
0.02310308814048767,
-0.007612818852066994,
-0.001977055799216032,
-0.002998662879690528,
-0.004046425223350525,
-0.010376080870628357,
-0.01922590658068657,
0.024629345163702965,
0.0344146192073822,
0.00025694031501188874,
-0.012727008201181889,
-0.020567534491419792,
-0.0033879196271300316,
-0.00372948101721704,
0.02789110317826271,
-0.009256006218492985,
0.016678042709827423,
0.02225380204617977,
-0.021515289321541786,
-0.007317414041608572,
-0.0006235034088604152,
0.009409862570464611,
0.01896742731332779,
0.03003278560936451,
0.0029386586975306273,
-0.01420402992516756,
0.017391936853528023,
-0.01032684650272131,
-0.04581230506300926,
-0.007311259862035513,
0.0037202497478574514,
-0.01760118082165718,
0.0012877787230536342,
-0.02562633529305458,
0.01456097699701786,
-0.020666003227233887,
0.0026155600789934397,
-0.037959471344947815,
0.004944947082549334,
0.01612415909767151,
-0.019779788330197334,
-0.02013673633337021,
0.014930232428014278,
-0.016998063772916794,
-0.015939531847834587,
-0.019435150548815727,
0.031362105160951614,
-0.00040579645428806543,
-0.039313409477472305,
0.030278954654932022,
0.003366379765793681,
0.010136065073311329,
0.017835043370723724,
-0.010234532877802849,
0.004760319367051125,
0.04536920040845871,
0.020752161741256714,
0.01787196844816208,
-0.017318084836006165,
0.022475354373455048,
0.01592722348868847,
0.012597768567502499,
-0.012837784364819527,
-0.008665196597576141,
0.009336011484265327,
-0.019053585827350616,
0.019841331988573074,
-0.02245073765516281,
0.023189248517155647,
-0.014548668637871742,
0.013600912876427174,
-0.008012845180928707,
-0.011736172251403332,
0.011145363561809063,
-0.0045049176551401615,
-0.02104756608605385,
0.0033879196271300316,
-0.011096129193902016,
-0.04083966463804245,
0.013367051258683205,
-0.01531179714947939,
-0.01245622057467699,
-0.0028848089277744293,
-0.016062617301940918,
-0.011853103525936604,
-0.019853640347719193,
-0.007292797323316336,
-0.016136467456817627,
0.053172800689935684,
-0.016407255083322525,
-0.010406852699816227,
0.03635936230421066,
0.030574358999729156,
-0.006086562294512987,
-0.03347916901111603,
0.030894381925463676,
0.008357483893632889,
-0.0015108706429600716,
-0.017650416120886803,
0.013034720905125141,
0.04517226293683052,
-0.04275979474186897,
-0.006249650381505489,
0.006255804561078548,
-0.02485089935362339,
-0.02104756608605385,
-0.005818852223455906,
0.00040425790939480066,
0.03138672187924385,
0.018278149887919426,
-0.005301894154399633,
0.004495686385780573,
0.013342433609068394,
0.016604190692305565,
0.03094361536204815,
-0.007606664206832647,
-0.008757511153817177,
0.05361590534448624,
0.01597645692527294,
-0.01708422414958477,
-0.003920263145118952,
-0.009169845841825008,
0.003987960051745176,
-0.0438675582408905,
-0.037245575338602066,
-0.009176000021398067,
0.020752161741256714,
0.00022097636247053742,
0.0012593152932822704,
-0.03003278560936451,
-0.0013962475350126624,
0.018659714609384537,
-0.014142487198114395,
-0.019890565425157547,
-0.009809888899326324,
0.015545658767223358,
-0.017847351729869843,
0.006905078887939453,
-0.02285691909492016,
-0.022684600204229355,
0.029983550310134888,
0.005529602058231831,
0.009489867836236954,
0.030992848798632622,
0.011249985545873642,
0.005954245571047068,
0.006437355186790228,
-0.0023309257812798023,
-0.007822063751518726,
0.004147970583289862,
-0.03877183422446251,
0.002927888883277774,
-0.03308529779314995,
-0.0030186641961336136,
0.017773499712347984,
-0.013256274163722992,
-0.025650952011346817,
-0.023767748847603798,
0.010012979619204998,
0.0026894111651927233,
0.03542391583323479,
-0.020567534491419792,
-0.007945148274302483,
0.010191453620791435,
0.010794570669531822,
0.007852834649384022,
-0.052532754838466644,
0.02924503944814205,
-0.01025915052741766,
0.01209927350282669,
0.016407255083322525,
-0.013551678508520126,
-0.02478935569524765,
0.026980271562933922,
0.007975920103490353,
-0.0016231858171522617,
-0.016284169629216194,
-0.00021905316680204123,
0.012080810964107513,
0.00495110172778368,
0.019324373453855515,
0.00883751641958952,
0.008917521685361862,
-0.03384842723608017,
-0.02104756608605385,
0.019201287999749184,
-0.0053880540654063225,
0.013970168307423592,
0.027029506862163544,
0.016407255083322525,
-0.029417358338832855,
0.01883203350007534,
-0.02749723009765148,
0.02912195399403572,
-0.019299756735563278,
-0.017010372132062912,
0.007902069017291069,
0.009299085475504398,
-0.018204297870397568,
0.0045049176551401615,
-0.0239400677382946,
0.007551276125013828,
0.0017862737877294421,
0.017699649557471275,
-0.01630878634750843,
-0.0007873605354689062,
-0.006271190010011196,
0.00158626027405262,
-0.012031576596200466,
0.015434881672263145,
0.014167104847729206,
-0.024358557537198067,
0.020038267597556114,
-0.021195268258452415,
0.034980807453393936,
0.00563114695250988,
0.019718246534466743,
0.010616096667945385,
-0.027595698833465576,
0.008991372771561146,
-0.005477290600538254,
0.015471807681024075,
0.014302498660981655,
0.022499971091747284,
-0.02860499732196331,
-0.020678311586380005,
0.03126363828778267,
0.03626089543104172,
-0.019902873784303665,
-0.01858586259186268,
-0.02149067260324955,
-0.015902604907751083,
0.002278614556416869,
-0.02038290724158287,
0.010216070339083672,
0.0026894111651927233,
0.005040338262915611,
0.017625797539949417,
0.015262562781572342,
-0.017835043370723724,
0.006228110287338495,
-0.026266377419233322,
0.014228647574782372,
0.008172856643795967,
-0.0469939224421978,
-0.058933187276124954,
0.008037462830543518,
0.007551276125013828,
-0.038033321499824524,
-0.002481705043464899,
-0.010831495746970177,
0.00763743557035923,
0.04852018132805824,
-0.024900132790207863,
0.013083955273032188,
0.07065089792013168,
0.012776241637766361,
-0.022413812577724457,
-0.00896675605326891,
0.014044019393622875,
-0.0077482121996581554,
-0.01735501177608967,
-0.02680795267224312,
-0.04347368702292442,
0.02661101706326008,
0.021589141339063644,
-0.00789591483771801,
0.022229183465242386,
0.03461155295372009,
-0.01813044771552086,
-0.02219225838780403,
0.0023801596835255623,
0.00007587047730339691,
0.04711700975894928,
-0.011926954612135887,
-0.020161353051662445,
-0.012640848755836487,
-0.019459767267107964,
-0.03067282773554325,
-0.016801128163933754,
0.013465519063174725,
0.003029434010386467,
-0.007803600747138262,
0.06065637990832329,
0.03749174624681473,
-0.032716043293476105,
-0.030377423390746117,
0.029368124902248383,
0.027743401005864143,
-0.022487662732601166,
0.001534718438051641,
0.005655764136463404,
-0.0033725339453667402,
-0.04571383818984032,
0.017244234681129456,
0.010788416489958763,
-0.02892501838505268,
0.008769819512963295,
0.018881266936659813,
-0.014228647574782372,
0.01174848061054945,
0.02614329382777214,
-0.017638107761740685,
-0.0009339088574051857,
-0.018155064433813095,
-0.005797312129288912,
-0.02039521560072899,
0.0008069772156886756,
-0.005646532867103815,
-0.034537702798843384,
-0.018155064433813095,
0.003243294544517994,
-0.01909051276743412,
0.04396602883934975,
0.014302498660981655,
0.01285009365528822,
-0.018425852060317993,
0.02258613146841526,
-0.04381832480430603,
-0.009594489820301533,
-0.021909162402153015,
0.015939531847834587,
-0.02769416570663452,
-0.01235775277018547,
-0.02471550554037094,
0.005028029903769493,
0.016739584505558014,
-0.01330550853163004,
-0.043129049241542816,
-0.005292662885040045,
0.028703464195132256,
-0.002572480356320739,
0.011311528272926807,
0.0246539618819952,
-0.007311259862035513,
0.009674495086073875,
0.0013177806977182627,
-0.026709485799074173,
-0.020801395177841187,
0.024998601526021957,
0.009151383303105831,
-0.012837784364819527,
-0.02899886853992939,
-0.02562633529305458,
0.0025278618559241295,
-0.04332598298788071,
0.0066466000862419605,
-0.01080687902867794,
-0.02848191186785698,
0.02646331489086151,
-0.010271458886563778,
-0.010868421755731106,
-0.014868690632283688,
0.00870827678591013,
-0.014056327752768993,
-0.009299085475504398,
0.012628539465367794,
0.012154662050306797,
-0.005184963345527649,
0.032912977039813995,
-0.020727545022964478,
0.0033386857248842716,
0.0093852449208498,
0.017551947385072708,
-0.027669548988342285,
0.008394409902393818,
0.035054661333560944,
-0.006218879017978907,
-0.022106099873781204,
0.033823806792497635,
0.03384842723608017,
-0.024973982945084572,
0.016604190692305565,
-0.014117870479822159,
-0.015619509853422642,
-0.005945014301687479,
-0.016271861270070076,
0.010603788308799267,
-0.006991238333284855,
0.017010372132062912,
0.026044825091958046,
0.002240150235593319,
-0.02214302495121956,
-0.0042556701228022575,
-0.028432678431272507,
-0.019644394516944885,
0.013330125249922276,
0.015250254422426224,
-0.03840257599949837,
0.0048834048211574554,
0.003052512649446726,
0.010111447423696518,
0.04241515323519707,
0.007551276125013828,
-0.011631550267338753,
-0.009976054541766644,
-0.013465519063174725,
-0.025330930948257446,
0.004194127861410379,
-0.014450200833380222,
-0.012763933278620243,
0.035054661333560944,
0.012825476005673409,
-0.006480434909462929,
0.032716043293476105,
0.023090779781341553,
-0.006726605352014303,
-0.016345713287591934,
-0.028826549649238586,
0.011810023337602615,
-0.0055080619640648365,
-0.019299756735563278,
0.1228882446885109,
-0.003914108965545893,
0.001958593027666211,
-0.01255468837916851,
-0.010413006879389286,
0.0005531140486709774,
0.005858854856342077,
0.012154662050306797,
0.046304646879434586,
-0.003846412058919668,
0.026118675246834755,
0.00986527744680643,
0.028777316212654114,
0.02574942074716091,
0.051941946148872375,
-0.015582583844661713,
-0.006621982902288437,
0.03306068107485771,
-0.024506259709596634,
-0.0019493616418913007,
-0.009976054541766644,
0.019398225471377373,
-0.011576161719858646,
0.02550324983894825,
-0.001391631900332868,
-0.005655764136463404,
-0.008111313916742802,
-0.021662991493940353,
0.03150980547070503,
-0.03165750950574875,
-0.01330550853163004,
-0.014142487198114395,
0.03909185528755188,
-0.016973447054624557,
0.014831764623522758,
-0.0019755172543227673,
-0.030328189954161644,
-0.017650416120886803,
0.005634224507957697,
-0.005929628852754831,
0.007077398244291544,
-0.0071512493304908276,
0.010536091402173042,
0.004963410086929798,
0.041135068982839584,
-0.00758820166811347,
-0.05898242071270943,
0.0010785339400172234,
-0.0010685332817956805,
-0.01656726561486721,
-0.021970706060528755,
0.0093852449208498,
0.020296746864914894,
-0.008037462830543518,
-0.02024751342833042,
-0.014622519724071026,
0.00905906967818737,
-0.01258546020835638,
0.01057917159050703,
-0.030328189954161644,
0.005120343528687954,
0.02336156740784645,
0.01586567983031273,
0.023263100534677505,
-0.003741789609193802
] | 2025-01-06 | 50 | 39759518 | [
"CAR-T cell infiltration",
"CAR-T cell tumor infiltration",
"CAR-T cells",
"solid tumors",
"The anti-CEA scFab CAR-T cells",
"CAR-T cell therapy",
"scFab CAR-T therapy",
"improved antigen specific expansion",
"limited efficacy",
"overall efficacy",
"CEA",
"prior treatment",
"a metastatic triple negative breast cancer",
"IGRT",
"two anti-CEA single-chain Fab (scFab) CAR-T cells",
"Image-Guided Radiation Therapy",
"CD28zeta",
"persistence",
"domains",
"both the primary tumor and distant metastatic lesions",
"Fab",
"a strong antitumor response",
"three different human donors",
"both primary and metastatic lesions",
"(TNBC) model",
"the combination",
"the lungs",
"These findings",
"this hypothesis",
"4-1BBzeta"
] | [
"carcinoembryonic antigen",
"cell immunotherapy",
"chimeric antigen receptor T cells",
"image-guided radiation therapy",
"triple-negative breast cancer"
] | 0 | 10.3389/fimmu.2024.1499471
10.1016/j.compbiomed.2022.105508
10.18632/oncotarget.12284
10.3390/molecules29071646
10.1517/13543784.2012.681045
10.1001/jamaoncol.2018.7147
10.1186/s40425-018-0460-5
10.1126/science.ade0156
10.1186/s13287-020-02128-1
10.3892/ol.2023.13867
10.1186/s12943-023-01775-1
10.3389/pore.2022.1610378
10.1186/s13073-019-0653-7
10.1001/jamaoncol.2019.1478
10.1200/JCO.2018.36.15_suppl.6009
10.1093/neuonc/noac239
10.1016/j.semradonc.2019.12.004
10.3390/cells11121974
10.1002/1097-0142(19940901)74:5<1575::AID-CNCR2820740513>3.0.CO;2-W
10.1016/j.jons.2017.01.001
10.1093/protein/gzh056
10.1080/2162402X.2021.1899469
10.1053/j.gastro.2012.06.037
10.4236/abb.2013.44A011
10.1016/j.tips.2015.11.004
10.7150/jca.30163
10.1073/pnas.1524155113
10.1073/pnas.1810060115
10.1080/2162402X.2020.1724052
10.1038/leu.2017.57
10.1038/nature03799
10.1038/s41392-023-01462-z
10.3389/fimmu.2021.813832
10.1371/journal.pone.0106921
10.4161/mabs.2.1.10786
10.1016/j.immuni.2016.01.021
10.1158/2767-9764.CRC-22-0185
10.1038/s41571-023-00832-4
10.1158/2326-6066.CIR-22-0840
10.3390/cells13131075
10.1038/s41419-023-05829-6
10.1038/s41467-022-33968-5
10.1016/j.ymthe.2018.09.008
10.1038/bjc.2013.502
10.1172/JCI30740
10.1016/j.ijrobp.2012.01.011
10.3109/09553002.2012.692495
10.1158/0008-5472.CAN-19-1323
10.1093/jnci/85.12.988
10.1016/j.immuni.2020.04.019
10.1038/s41577-019-0221-9 | [
"Aniogo",
"Kujawski",
"Awuah",
"Cha",
"Espinosa",
"Hui",
"Ghimire",
"Yazaki",
"Brown",
"Wang",
"Shively"
] | [
"Department of Immunology and Theranostics, City of Hope, Duarte, CA, United States.",
"Department of Immunology and Theranostics, City of Hope, Duarte, CA, United States.",
"T-Cell Therapeutic Laboratory, City of Hope, Duarte, CA, United States.",
"Department of Immunology and Theranostics, City of Hope, Duarte, CA, United States.",
"T-Cell Therapeutic Laboratory, City of Hope, Duarte, CA, United States.",
"Department of Radiation Oncology, City of Hope, Duarte, CA, United States.",
"Department of Radiation Oncology, City of Hope, Duarte, CA, United States.",
"Department of Immunology and Theranostics, City of Hope, Duarte, CA, United States.",
"Department of Hematology & Hematopoietic Cell Transplantation, City of Hope Beckman Research Institute and Medical Center, Duarte, CA, United States.",
"T-Cell Therapeutic Laboratory, City of Hope, Duarte, CA, United States.",
"Department of Immunology and Theranostics, City of Hope, Duarte, CA, United States."
] | [
"39759518",
"35447458",
"27765921",
"38611925",
"22500582",
"30973611",
"30514386",
"36520914",
"33494834",
"37274466",
"37173782",
"35832115",
"31221199",
"31294749",
"32822275",
"36239313",
"32381294",
"35741103",
"7914825",
"15316127",
"33796409",
"22750462",
"25635232",
"26705086",
"31205546",
"26759369",
"30373813",
"32117587",
"28202953",
"16049480",
"37208386",
"35095911",
"25226518",
"20093855",
"26885860",
"36968221",
"37904019",
"37540803",
"38994929",
"37142568",
"36261437",
"30415658",
"24002607",
"17415413",
"22420973",
"22574668",
"31427377",
"8496984",
"32433943",
"31570879"
] | [] | 9.601356 | 5.726479 |
39757684 | 75 | Revolutionizing Cancer Treatment: Unveiling the Power of CAR T-cell Therapy. | Cancer is a significant health challenge worldwide, causing social and economic burdens. Despite advancements in medicine, it remains a leading cause of death and is projected to increase by 2040. While conventional treatments like surgery, radiation, and chemotherapy are effective, they often have severe side effects. CAR T-cell (chimeric antigen receptor T-cell) treatment is a novel immunotherapy method personalized to the patient's immune system and directly targets cancer cells. It originated in the 1980s, and advancements have made it more effective. However, challenges remain, such as severe side effects, high costs, and manufacturing variability. Despite these challenges, the treatment with CAR T-cells has shown remarkable success, especially in hematologic malignancies. Though it is new to solid tumours, ongoing research looks promising. CAR T-cell therapy offers hope for fightingcancer, and it stands poised to redefine cancer treatment paradigms, giving renewed optimism to patients globally. | [
0.005489378236234188,
0.008667130954563618,
0.07312928885221481,
0.08567643910646439,
-0.03717327490448952,
-0.026990419253706932,
0.012828056700527668,
0.01745130680501461,
0.01053398847579956,
0.0159414354711771,
-0.00012125059583922848,
-0.034223757684230804,
-0.04735612869262695,
0.0008478397503495216,
-0.0014711007243022323,
-0.023350341245532036,
0.024485670030117035,
-0.0015479110879823565,
0.027013827115297318,
0.033755578100681305,
0.019417650997638702,
-0.0005877818912267685,
-0.0019458617316558957,
-0.0263349711894989,
-0.0281374529004097,
0.007022658828645945,
0.005799545906484127,
0.01528598740696907,
-0.0471220389008522,
-0.04590477794408798,
0.010299899615347385,
-0.018048232421278954,
-0.02642860636115074,
-0.04234663397073746,
0.0033767283894121647,
0.022507620975375175,
0.022776823490858078,
0.027013827115297318,
-0.0035727776121348143,
-0.007642993703484535,
0.010844155214726925,
0.017556646838784218,
0.025843383744359016,
0.0950399786233902,
-0.053980838507413864,
-0.04677090793848038,
-0.0010943643283098936,
-0.07294201850891113,
-0.0074791316874325275,
-0.014220884069800377,
-0.011698579415678978,
-0.006454993970692158,
-0.015484962612390518,
0.03621350973844528,
-0.05800716206431389,
0.028629038482904434,
-0.043680936098098755,
0.04253390431404114,
-0.005474747624248266,
0.007549358066171408,
-0.002351127564907074,
-0.008105318993330002,
0.003344541182741523,
-0.027294734492897987,
-0.055385369807481766,
0.020810479298233986,
-0.04627932235598564,
-0.017697099596261978,
-0.023923857137560844,
0.01707676611840725,
0.013682479970157146,
-0.019651740789413452,
0.006589594762772322,
0.012348175048828125,
0.013530322350561619,
-0.000695682130753994,
-0.01882072538137436,
0.011341594159603119,
0.023455679416656494,
0.00037783366860821843,
0.03249150142073631,
-0.033615127205848694,
0.012909987941384315,
-0.03766486048698425,
-0.018282322213053703,
0.006577890366315842,
-0.008790028281509876,
-0.005416225641965866,
-0.04126982390880585,
0.01530939619988203,
-0.020494459196925163,
0.006390619557350874,
-0.035628288984298706,
0.022835345938801765,
0.007116294000297785,
0.005176284816116095,
-0.03080606274306774,
-0.02647542394697666,
0.05023542046546936,
0.022788528352975845,
0.05711762607097626,
0.04201890900731087,
-0.01576586812734604,
-0.007010954432189465,
0.04859679937362671,
0.01463053934276104,
-0.05135904625058174,
-0.013097258284687996,
0.03298308700323105,
0.010967052541673183,
-0.0003209574497304857,
-0.012757830321788788,
-0.012523741461336613,
0.03211696073412895,
-0.027622457593679428,
-0.04878406971693039,
-0.006583742797374725,
-0.01413895282894373,
0.005167506635189056,
0.05196767672896385,
-0.01848129741847515,
0.02535179816186428,
0.03717327490448952,
-0.005392816849052906,
-0.0020936301443725824,
-0.015250873751938343,
0.06615344434976578,
-0.02809063531458378,
-0.028067225590348244,
-0.04187845438718796,
0.013202598318457603,
0.022882163524627686,
-0.006981693208217621,
-0.013424982316792011,
-0.0886259526014328,
0.007765890099108219,
-0.030314477160573006,
0.014806105755269527,
-0.01702994666993618,
0.006882205605506897,
0.0207519568502903,
-0.024766577407717705,
-0.006712491158396006,
-0.010879268869757652,
-0.006583742797374725,
-0.04831589385867119,
-0.006238461937755346,
0.029190851375460625,
0.01924208551645279,
0.03609646484255791,
-0.03747759014368057,
0.04581114277243614,
0.07135020941495895,
0.032959677278995514,
-0.00021287435083650053,
-0.023549316450953484,
0.006689082365483046,
0.07027340680360794,
-0.04482797160744667,
-0.054168108850717545,
-0.008386225439608097,
-0.02432180754840374,
-0.04686454311013222,
-0.0327489972114563,
0.027903364971280098,
-0.006156530696898699,
-0.009281613864004612,
0.0012882190058007836,
-0.03747759014368057,
-0.019628331065177917,
-0.026967009529471397,
-0.04590477794408798,
-0.06648117303848267,
-0.008251624181866646,
-0.01735767163336277,
0.019721966236829758,
0.021512744948267937,
0.0189143605530262,
-0.01316748559474945,
-0.03174241632223129,
-0.016772450879216194,
0.04129323363304138,
0.03363853693008423,
0.003277240786701441,
-0.02131376974284649,
0.016807563602924347,
-0.004163851495832205,
0.003204087959602475,
-0.04033346846699715,
-0.013050440698862076,
-0.0010475466260686517,
-0.00730356527492404,
0.04021642729640007,
0.009697121568024158,
0.0025793639943003654,
0.029799481853842735,
0.05880306288599968,
0.02591361105442047,
-0.010223820805549622,
-0.00806435290724039,
0.019581513479351997,
-0.02968243695795536,
-0.053419023752212524,
-0.009398658759891987,
-0.03010379709303379,
-0.05093768611550331,
-0.008778323419392109,
0.04075482860207558,
-0.0019063592189922929,
-0.009334283880889416,
0.01830573007464409,
-0.007982422597706318,
-0.017989709973335266,
0.025375207886099815,
-0.03122742287814617,
-0.03178923577070236,
-0.0047841863706707954,
0.04407888650894165,
0.0350898839533329,
0.03263195604085922,
0.002260418375954032,
0.0209860447794199,
0.0005237733130343258,
-0.008386225439608097,
-0.030829472467303276,
-0.009796609170734882,
0.011897554621100426,
-0.0026013099122792482,
-0.015414736233651638,
-0.013588844798505306,
-0.03317035734653473,
-0.0030548565555363894,
0.03169560059905052,
-0.010393534786999226,
-0.06414028257131577,
-0.026709511876106262,
0.020611504092812538,
0.0019443986238911748,
0.05009496584534645,
-0.003198235761374235,
0.015484962612390518,
0.005860994104295969,
0.0010153594193980098,
-0.04576432704925537,
-0.021840468049049377,
-0.01053983997553587,
-0.005846363492310047,
-0.053372208029031754,
0.03139128535985947,
-0.011634204536676407,
0.0071104420349001884,
0.020728547126054764,
-0.002335034077987075,
-0.011230401694774628,
0.04421934112906456,
0.007180668413639069,
0.023596134036779404,
-0.055713094770908356,
0.025094300508499146,
-0.016959721222519875,
-0.0029612211510539055,
-0.003362097777426243,
-0.04625591263175011,
-0.04869043454527855,
-0.06264211982488632,
0.01152301300317049,
-0.006501811556518078,
0.011335741728544235,
0.04356389492750168,
-0.016526656225323677,
0.04033346846699715,
0.0016137484926730394,
0.053231753408908844,
-0.015075307339429855,
-0.054027654230594635,
0.022882163524627686,
-0.0015362065751105547,
0.04962678998708725,
0.019640035927295685,
0.03345126286149025,
-0.01838766224682331,
0.013003623113036156,
-0.006735900416970253,
-0.04225299879908562,
0.001953176921233535,
-0.013811228796839714,
0.010972904041409492,
-0.0016576400958001614,
0.011540569365024567,
-0.028160860762000084,
0.01914845034480095,
0.00028584414394572377,
-0.02535179816186428,
-0.000898315105587244,
-0.03382580727338791,
-0.011002165265381336,
0.01053398847579956,
-0.0207519568502903,
-0.03396625816822052,
0.0281374529004097,
-0.03607305884361267,
0.005471821408718824,
-0.0346217080950737,
-0.0328192263841629,
0.0364241898059845,
0.026662694290280342,
-0.003268462372943759,
-0.03038470447063446,
0.020494459196925163,
0.04176140949130058,
-0.0008514974033460021,
0.015602006576955318,
0.03942052274942398,
0.017111878842115402,
0.012465219013392925,
0.03249150142073631,
0.028535403311252594,
-0.06086304411292076,
0.006940727587789297,
-0.04557705670595169,
-0.02267148345708847,
-0.005471821408718824,
-0.014829514548182487,
0.04716885834932327,
0.017100173979997635,
-0.06774524599313736,
0.03609646484255791,
-0.00006067101639928296,
0.01834084466099739,
-0.03724350035190582,
-0.0006258212961256504,
-0.040895283222198486,
0.05215494707226753,
-0.03635396435856819,
0.003762974636629224,
-0.00884269829839468,
0.0033269845880568027,
-0.07177156955003738,
0.028254497796297073,
-0.014478381723165512,
0.02033059671521187,
0.007748333737254143,
-0.04148050397634506,
0.05107813701033592,
-0.002153615467250347,
-0.0475902184844017,
-0.02150104008615017,
0.010814894922077656,
0.007941456511616707,
0.03815644606947899,
0.022648073732852936,
0.03207014128565788,
0.04864361509680748,
0.03122742287814617,
-0.026522241532802582,
0.04501524195075035,
-0.03965461254119873,
-0.005711762700229883,
0.03001016192138195,
-0.0003749075694940984,
0.03623691946268082,
-0.028769491240382195,
-0.02591361105442047,
0.054495833814144135,
0.06858796626329422,
0.07996467500925064,
-0.03593260422348976,
0.03956097736954689,
-0.008620313368737698,
-0.036143284291028976,
-0.01645643077790737,
-0.007988274097442627,
0.014349632896482944,
-0.010182855650782585,
-0.036143284291028976,
0.02173512801527977,
-0.00046415385440923274,
0.03410671278834343,
0.028441768139600754,
0.024672940373420715,
0.03405989333987236,
-0.011815623380243778,
-0.025047482922673225,
0.00785367377102375,
-0.006888058036565781,
0.04995451122522354,
0.019920941442251205,
-0.0009092880063690245,
-0.04267435520887375,
-0.0022428615484386683,
-0.0021609305404126644,
-0.00999558437615633,
0.011318185366690159,
0.005132392980158329,
-0.01486462727189064,
0.0701797679066658,
-0.04506206139922142,
0.07860696315765381,
0.027154279872775078,
0.014080430381000042,
0.020564686506986618,
-0.04831589385867119,
-0.01420917920768261,
-0.03946734219789505,
0.02944834902882576,
-0.0168426763266325,
0.020108213648200035,
0.025234753265976906,
0.029799481853842735,
-0.022706596180796623,
0.014033612795174122,
0.031719010323286057,
0.04468751698732376,
0.04733271896839142,
-0.03089969791471958,
-0.01924208551645279,
-0.02869926579296589,
0.03551124408841133,
-0.0251645278185606,
0.03223400563001633,
0.03909280151128769,
-0.028254497796297073,
0.007841968908905983,
0.005746875889599323,
0.009732234291732311,
0.03722009062767029,
0.027950182557106018,
0.009369397535920143,
-0.009831721894443035,
-0.03089969791471958,
-0.00544548686593771,
0.06325075030326843,
0.006560333538800478,
-0.011341594159603119,
0.02050616405904293,
0.06222075596451759,
-0.054683104157447815,
0.0030197433661669493,
-0.03230423107743263,
0.027926772832870483,
-0.04660704359412193,
0.01416236162185669,
0.007496688049286604,
-0.01612870581448078,
0.054214924573898315,
-0.007005102001130581,
0.011622500605881214,
0.05796034261584282,
-0.02385363169014454,
-0.05065677687525749,
-0.027786320075392723,
-0.02530498057603836,
-0.011850737035274506,
-0.00035351040423847735,
-0.0632975623011589,
0.003616669215261936,
0.015040194615721703,
-0.08848550170660019,
0.02116161212325096,
0.027294734492897987,
0.03174241632223129,
-0.04440661147236824,
0.009743939153850079,
-0.04677090793848038,
-0.005091427825391293,
0.05037587136030197,
0.04199549928307533,
-0.0263349711894989,
-0.0057176146656274796,
-0.01603507064282894,
0.009568372741341591,
0.02120842970907688,
-0.013108963146805763,
0.0010716869728639722,
0.012219426222145557,
0.04826907441020012,
-0.004558876156806946,
0.02017843909561634,
0.013155780732631683,
0.0126993078738451,
-0.008754914626479149,
0.005132392980158329,
-0.022706596180796623,
0.008801732212305069,
0.007572766859084368,
-0.035253748297691345,
-0.014349632896482944,
-0.00630283635109663,
-0.03420034795999527,
0.03956097736954689,
0.002746152225881815,
-0.0016430096002295613,
0.03616669401526451,
-0.00987854041159153,
-0.02337374910712242,
-0.0057907672598958015,
-0.013963386416435242,
-0.004675920121371746,
-0.009070933796465397,
0.008672983385622501,
0.02167660742998123,
0.03263195604085922,
-0.002819304820150137,
0.027645867317914963,
0.030782654881477356,
0.03932688757777214,
0.035487834364175797,
0.07481472194194794,
-0.013612253591418266,
0.03246809169650078,
-0.05131222680211067,
-0.01011262834072113,
0.05655581131577492,
-0.01323771197348833,
-0.03405989333987236,
-0.024064309895038605,
-0.054542649537324905,
-0.005208471789956093,
0.012863170355558395,
-0.03155514597892761,
-0.018516410142183304,
0.017334261909127235,
0.0186802726238966,
0.016479838639497757,
-0.0005501082632690668,
-0.03401307761669159,
-0.02628815360367298,
-0.008830993436276913,
-0.015520076267421246,
-0.029471758753061295,
0.024064309895038605,
-0.012266243807971478,
0.009152865037322044,
0.025234753265976906,
-0.02600724622607231,
-0.014302815310657024,
-0.04269776493310928,
0.03075924515724182,
-0.012254539877176285,
-0.032959677278995514,
-0.00018873396038543433,
-0.003569851629436016,
0.011189436540007591,
-0.01603507064282894,
-0.005486452020704746,
0.03607305884361267,
-0.0029743886552751064,
-0.01966344378888607,
0.03108697012066841,
-0.021887285634875298,
0.03600282967090607,
-0.03820326551795006,
0.009217239916324615,
-0.019031405448913574,
0.028114043176174164,
-0.009855130687355995,
-0.01852811500430107,
-0.02295238897204399,
-0.01211408618837595,
-0.02883971855044365,
-0.01595314033329487,
-0.020155031234025955,
0.007321121636778116,
-0.01637449860572815,
-0.019686853513121605,
0.026686104014515877,
-0.02511771023273468,
-0.024111129343509674,
-0.04492160677909851,
0.025609295815229416,
0.0024433000944554806,
0.007888786494731903,
0.00886610709130764,
-0.04726249352097511,
0.024204764515161514,
0.01456031296402216,
-0.0001802299520932138,
0.0090065598487854,
-0.02497725561261177,
0.045694101601839066,
-0.027318142354488373,
0.02318647876381874,
-0.01265249028801918,
0.054261744022369385,
0.006355506367981434,
0.014384745620191097,
-0.04957997053861618,
-0.004643733147531748,
-0.006449141539633274,
-0.0028953836299479008,
0.05103132128715515,
0.0061506787315011024,
0.04550682753324509,
-0.0025442508049309254,
-0.028348132967948914,
-0.00743231363594532,
-0.006525220349431038,
0.0009743939153850079,
-0.008901219815015793,
-0.004354048520326614,
-0.03108697012066841,
0.010100924409925938,
-0.01150545570999384,
-0.038273490965366364,
-0.03108697012066841,
0.008052648976445198,
-0.015555188991129398,
-0.008555939421057701,
0.004687624517828226,
0.0016152114840224385,
0.02944834902882576,
0.024392034858465195,
-0.03195309638977051,
0.013272824697196484,
0.04854997992515564,
0.015204056166112423,
-0.020096508786082268,
-0.0012011672370135784,
0.009065082296729088,
-0.001793704112060368,
-0.0156722329556942,
-0.005246511194854975,
-0.00728015648201108,
0.002288216259330511,
-0.004035102669149637,
-0.022449098527431488,
-0.01628086343407631,
0.006636412348598242,
0.022495916113257408,
-0.01272271666675806,
0.016058480367064476,
-0.023502498865127563,
-0.024064309895038605,
0.014618834480643272,
-0.020201848819851875,
-0.005038757808506489,
0.0368923656642437,
-0.0256327036768198,
0.013904863968491554,
-0.002395019168034196,
-0.016877789050340652,
0.01693631149828434,
-0.0033094279933720827,
-0.02013162150979042,
-0.007537653669714928,
-0.03317035734653473,
-0.039584387093782425,
-0.03043152205646038,
0.004190186504274607,
0.0016415464924648404,
0.02446226216852665,
-0.010311603546142578,
0.016538361087441444,
-0.05285721272230148,
0.007730776909738779,
-0.0003924642223864794,
0.01204385980963707,
0.006238461937755346,
0.07092885673046112,
0.08239919692277908,
-0.03239786624908447,
0.025234753265976906,
0.006940727587789297,
-0.02013162150979042,
-0.009468885138630867,
0.005893181078135967,
0.020260371267795563,
0.000452815176686272,
-0.00735038286074996,
0.003107526572421193,
0.06076940894126892,
0.023069433867931366,
0.021910695359110832,
-0.024626122787594795,
0.0006492301472462714,
0.006730047985911369,
0.011089948937296867,
-0.021477632224559784,
-0.006016077473759651,
0.009445476345717907,
-0.01479440089315176,
0.00640817591920495,
-0.022133080288767815,
-0.026662694290280342,
0.025702930986881256,
0.008052648976445198,
0.007777594495564699,
0.03537079319357872,
0.012617376632988453,
0.003648856421932578,
-0.0040058414451777935,
-0.018422774970531464,
-0.031157195568084717,
0.008655427023768425,
-0.004851486999541521,
-0.0029231817461550236,
0.014326224103569984,
-0.0019546400289982557,
-0.013436687178909779,
-0.04084846377372742,
0.027247916907072067,
0.021138202399015427,
0.02404090203344822,
-0.03239786624908447,
0.029659029096364975,
-0.02413453720510006,
-0.00527869863435626,
-0.02642860636115074,
0.01961662620306015,
0.039209846407175064,
0.008339406922459602,
-0.01702994666993618,
-0.019452765583992004,
-0.0035113294143229723,
0.015602006576955318,
-0.004342344123870134,
-0.010598362423479557,
0.04576432704925537,
-0.001125819981098175,
0.024345217272639275,
0.0017044577980414033,
0.015321100130677223,
-0.010405239649116993,
0.0014893888728693128,
0.018551522865891457,
0.01773221418261528,
-0.01863345503807068,
0.06193985044956207,
-0.02408771961927414,
-0.017252331599593163,
-0.0006836119573563337,
-0.03764145076274872,
-0.013073849491775036,
-0.011739544570446014,
-0.012465219013392925,
0.04304889962077141,
-0.027247916907072067,
-0.021863877773284912,
-0.00639647152274847,
0.003964876290410757,
0.02329181879758835,
-0.03127424046397209,
-0.010340864770114422,
-0.01481780968606472,
-0.01067444123327732,
0.01763857714831829,
0.01632768101990223,
0.010551544837653637,
-0.00449157552793622,
-0.035534653812646866,
0.03707963973283768,
0.008175545372068882,
-0.0067885699681937695,
-0.038039401173591614,
0.004874895792454481,
-0.03246809169650078,
0.0025398614816367626,
0.0021375217474997044,
-0.0180131196975708,
-0.013694184832274914,
-0.04817543923854828,
-0.005041683558374643,
0.004863191395998001,
0.006835388019680977,
0.003344541182741523,
0.025000665336847305,
0.040567558258771896,
0.027013827115297318,
-0.0035727776121348143,
0.01321430318057537,
-0.020295483991503716,
-0.005805397871881723,
0.012102382257580757,
-0.01599995791912079,
-0.013682479970157146,
0.018902655690908432,
-0.034972839057445526,
0.015508371405303478,
-0.014396450482308865,
-0.003215792588889599,
0.017322558909654617,
0.004093624651432037,
-0.026662694290280342,
0.01900799572467804,
0.0034586593974381685,
-0.011645909398794174,
0.013577139936387539,
0.02285875380039215,
-0.017802439630031586,
-0.013085554353892803,
-0.0071338508278131485,
0.0034147677943110466,
-0.019604923203587532,
0.03005697950720787,
-0.022589553147554398,
0.029799481853842735,
0.04356389492750168,
-0.04421934112906456,
-0.00469347694888711,
0.011879997327923775,
-0.007584471255540848,
-0.009843426756560802,
-0.000036576348065864295,
-0.0373605452477932,
-0.0071104420349001884,
0.013015327975153923,
-0.00472859013825655,
0.022320350632071495,
-0.02521134540438652,
0.006589594762772322,
0.006958284415304661,
-0.017228923738002777,
-0.005980964284390211,
-0.0030372999608516693,
-0.08979639410972595,
-0.01994435116648674,
0.02131376974284649,
0.004593989346176386,
0.002772487234324217,
-0.017158696427941322,
0.0647020936012268,
0.0030285215470939875,
0.005018274765461683,
-0.014478381723165512,
-0.025094300508499146,
-0.03703282028436661,
-0.021536152809858322,
0.009351840242743492,
0.018797317519783974,
-0.03001016192138195,
0.02239057794213295,
0.002261881250888109,
-0.032772406935691833,
0.0159414354711771,
-0.023198183625936508,
-0.0004923176602460444,
0.012991919182240963,
-0.010610067285597324,
0.018832430243492126,
0.04187845438718796,
0.03871825709939003,
-0.0364944152534008,
-0.021138202399015427,
-0.040427107363939285,
0.0013145538978278637,
0.009322579950094223,
-0.019651740789413452,
0.005600570235401392,
-0.015777572989463806,
-0.022191600874066353,
-0.00808776170015335,
-0.0016035070875659585,
-0.003215792588889599,
-0.006888058036565781,
0.029893117025494576,
0.02042423188686371,
0.00924650114029646,
-0.0030841175466775894,
0.053372208029031754,
0.03015061467885971,
-0.012219426222145557,
-0.005773210898041725,
-0.013062145560979843,
-0.0447811558842659,
0.04077823832631111,
-0.027482004836201668,
0.0008551549981348217,
-0.003250905778259039,
-0.019909238442778587,
-0.04045051336288452,
0.03143810108304024,
-0.0005336489412002265,
0.0026481274981051683,
-0.0063086883164942265,
0.005746875889599323,
0.022683188319206238,
-0.002408186672255397,
-0.03089969791471958,
-0.025000665336847305,
-0.012055564671754837,
0.01740448921918869,
-0.0256327036768198,
-0.008175545372068882,
-0.03719668090343475,
0.017978006973862648,
0.03342785686254501,
-0.014642243273556232,
-0.025094300508499146,
-0.009679564274847507,
0.009299170225858688,
0.0020994823426008224,
-0.015145533718168736,
-0.02089240960776806,
-0.015812687575817108,
-0.0020833888556808233,
-0.016269158571958542,
-0.030314477160573006,
0.02628815360367298,
-0.020389119163155556,
0.0033357630018144846,
-0.0374307706952095,
-0.013752706348896027,
-0.022636370733380318,
0.024251582100987434,
0.0105105796828866,
0.020354006439447403,
-0.019920941442251205,
0.007139703258872032,
-0.04719226807355881,
0.04962678998708725,
-0.021664902567863464,
-0.01314407680183649,
0.0009444013121537864,
0.009187978692352772,
-0.012242835015058517,
-0.008579348213970661,
-0.009667860344052315,
0.06198666989803314,
0.011610795743763447,
0.006882205605506897,
-0.03443443775177002,
-0.02130206488072872,
-0.020564686506986618,
-0.001839058822952211,
0.00637306272983551,
0.007344530429691076,
-0.01815357245504856,
0.04173800349235535,
0.0038975756615400314,
0.00947473756968975,
0.024157946929335594,
-0.006648116745054722,
0.02553906850516796,
0.01279294304549694,
0.02315136417746544,
0.014466676861047745,
0.0074674272909760475,
-0.008819288574159145,
-0.02572634071111679,
-0.010124333202838898,
-0.013354755938053131,
0.0626889318227768,
-0.003602038836106658,
-0.03565169870853424,
-0.0020058469381183386,
0.012242835015058517,
0.00735038286074996,
-0.019698558375239372,
0.020049691200256348,
0.04730931296944618,
0.06545118242502213,
-0.004301378503441811,
0.04314253479242325,
0.026896782219409943,
0.01688949391245842,
-0.011306480504572392,
0.02907380647957325,
-0.02069343440234661,
0.04166777431964874,
-0.0038097924552857876,
-0.0328192263841629,
0.01584780029952526,
0.0029597580432891846,
-0.004137516487389803,
0.009843426756560802,
0.04031006246805191,
0.02460271492600441,
-0.00002163719545933418,
-0.029424941167235374,
0.024111129343509674,
-0.035347383469343185,
-0.023081138730049133,
0.006051191128790379,
0.012313061393797398,
0.02337374910712242,
0.05140586197376251,
0.030174024403095245,
-0.029565393924713135,
-0.0035464426036924124,
0.03359171748161316,
0.033381037414073944,
0.03817985579371452,
-0.028909945860505104,
-0.01952299103140831,
-0.04693476855754852,
0.010229673236608505,
-0.014314519241452217,
0.0006675183540210128,
-0.027107462286949158,
0.008140431717038155,
0.05107813701033592,
0.02483680285513401,
-0.03750099614262581,
-0.013986795209348202,
-0.008661279454827309,
-0.03410671278834343,
-0.027973590418696404,
-0.03118060529232025,
0.043072305619716644,
0.054214924573898315,
-0.0052552898414433,
-0.03471534326672554,
0.037805311381816864,
0.0033357630018144846,
-0.04077823832631111,
0.005035831592977047,
0.04115277901291847,
-0.008772470988333225,
0.03272559121251106,
-0.014431564137339592,
0.03185946121811867,
-0.0007520096842199564,
-0.006068747490644455,
0.027622457593679428,
0.015566893853247166,
-0.039163026958703995,
-0.0030255955643951893,
-0.021934105083346367,
-0.028067225590348244,
-0.01528598740696907,
-0.022168193012475967,
-0.013577139936387539,
0.016877789050340652,
0.06638753414154053,
0.026077473536133766,
-0.014419859275221825,
-0.005056314170360565,
-0.01091438252478838,
-0.002753467531874776,
0.010323308408260345,
0.009164569899439812,
0.009808313101530075,
0.019078223034739494,
-0.02968243695795536,
-0.020857296884059906,
0.009117752313613892,
0.0012406697496771812,
0.06802615523338318,
0.019206970930099487,
0.01956980861723423,
-0.027903364971280098,
-0.014267701655626297,
0.010844155214726925,
0.04066119343042374,
-0.03623691946268082,
-0.024719757959246635,
-0.02047104947268963,
-0.018785612657666206,
0.020166734233498573,
0.023022616282105446,
0.019031405448913574,
0.04990769550204277,
0.0166085883975029,
0.0030782653484493494,
0.008883663453161716,
0.003344541182741523,
0.009258205071091652,
-0.006121417507529259,
0.02488362044095993,
-0.007666402496397495,
-0.014642243273556232,
0.038413941860198975,
0.010124333202838898,
0.0015127977821975946,
-0.05196767672896385,
0.021419109776616096,
0.0060394867323338985,
0.018329139798879623,
0.024719757959246635,
-0.008275032974779606,
0.003619595430791378,
0.0034118418116122484,
-0.034176938235759735,
0.010926086455583572,
0.00020281584875192493,
-0.020108213648200035,
-0.0009509850642643869,
0.003938541281968355,
-0.0024564675986766815,
-0.017474716529250145,
-0.0030811915639787912,
0.03242127597332001,
0.03583896905183792,
-0.020026281476020813,
-0.017954597249627113,
-0.01192681584507227,
-0.026452014222741127,
-0.020763661712408066,
-0.016339385882019997,
-0.03628373518586159,
0.0041931127198040485,
0.007631289307028055,
-0.04234663397073746,
0.02134888246655464,
0.003250905778259039,
-0.010750520043075085,
0.006636412348598242,
0.013975091278553009,
0.03443443775177002,
-0.012441810220479965,
-0.01975708082318306,
0.022332055494189262,
0.001790778012946248,
-0.03792235627770424,
-0.03679873049259186,
0.04218276962637901,
0.00226919655688107,
-0.04737953841686249,
0.027528822422027588,
0.006074599921703339,
-0.005989742930978537,
0.0007088496349751949,
-0.005732245277613401,
-0.0007362818578258157,
0.019640035927295685,
0.030080389231443405,
0.00835111178457737,
-0.004956826567649841,
0.010188707150518894,
-0.007619584910571575,
-0.028909945860505104,
-0.04332980513572693,
0.008813437074422836,
0.016479838639497757,
0.008345259353518486,
0.00640817591920495,
-0.0200848039239645,
0.026498831808567047,
-0.025328388437628746,
0.01838766224682331,
0.005834659095853567,
0.03298308700323105,
-0.002728595631197095,
-0.0068002743646502495,
0.0019166006240993738,
0.010212115943431854,
-0.014326224103569984,
-0.008708097040653229,
0.003207014175131917,
0.017802439630031586,
0.006636412348598242,
0.0030109649524092674,
-0.013694184832274914,
-0.03136787563562393,
-0.024813394993543625,
-0.013963386416435242,
-0.013202598318457603,
0.0650298222899437,
-0.030548565089702606,
-0.053419023752212524,
0.06006713956594467,
0.02342056669294834,
-0.013331347145140171,
-0.007748333737254143,
0.001334305154159665,
0.014443268068134785,
-0.005185062997043133,
0.0011645909398794174,
0.0017088470049202442,
0.003107526572421193,
-0.008140431717038155,
0.004237004090100527,
0.03574533388018608,
-0.00453839311376214,
0.0035201075952500105,
-0.013741002418100834,
-0.009258205071091652,
0.006355506367981434,
0.01598825305700302,
-0.022823641076683998,
0.009978028014302254,
0.011587386950850487,
0.03061879239976406,
0.04632613807916641,
0.010071663185954094,
-0.008029240183532238,
0.044991832226514816,
-0.0024681719951331615,
0.02036571130156517,
-0.0051528760232031345,
-0.020904114469885826,
0.01173369213938713,
-0.0049656047485768795,
-0.04737953841686249,
-0.017568351700901985,
-0.00003170712079736404,
0.015016784891486168,
-0.0071572596207261086,
-0.02117331698536873,
0.01740448921918869,
-0.016760746017098427,
-0.0309465155005455,
-0.021817060187458992,
-0.01571905054152012,
0.00030084047466516495,
-0.0044242748990654945,
0.010048254393041134,
-0.02375999465584755,
-0.03537079319357872,
0.016163820400834084,
0.00015471795632038265,
-0.0012867558980360627,
0.0429084450006485,
0.0030255955643951893,
0.007566914893686771,
0.017568351700901985,
0.0038039402570575476,
-0.001294802757911384,
-0.0019283050205558538,
-0.06128440052270889,
0.025328388437628746,
-0.03820326551795006,
-0.015859505161643028,
0.0020131622441112995,
-0.020014576613903046,
-0.05927123874425888,
-0.014689060859382153,
-0.009562520310282707,
-0.013471800833940506,
0.0038800190668553114,
0.014443268068134785,
-0.0005402326351031661,
0.01631597802042961,
-0.012593967840075493,
0.006929023191332817,
-0.03700941056013107,
0.03729031980037689,
-0.0034293984062969685,
0.019581513479351997,
0.014829514548182487,
-0.0012560317991301417,
-0.03565169870853424,
-0.006683230400085449,
-0.01060421485453844,
0.012921691872179508,
-0.01838766224682331,
-0.002209211466833949,
0.004134590271860361,
-0.00733867846429348,
0.03750099614262581,
-0.01105483528226614,
0.009802461601793766,
-0.027388369664549828,
-0.005003644153475761,
-0.015297691337764263,
0.016643701121211052,
0.009989731945097446,
0.03682214021682739,
0.02450907975435257,
-0.030408112332224846,
-0.005465969443321228,
-0.0038127184379845858,
-0.0010299899149686098,
-0.02299920655786991,
-0.013752706348896027,
0.005073870997875929,
0.005389890633523464,
-0.03300649672746658,
-0.004994865972548723,
-0.012640785425901413,
0.007929752580821514,
0.013916568830609322,
0.0016532508889213204,
-0.0283715408295393,
-0.02116161212325096,
-0.00929331872612238,
-0.018797317519783974,
0.0019458617316558957,
0.0058639198541641235,
0.014431564137339592,
0.009463032707571983,
0.0157073475420475,
-0.034270573407411575,
0.045694101601839066,
0.018844135105609894,
0.004877821542322636,
-0.015824390575289726,
-0.015087012201547623,
0.00017300611943937838,
0.013272824697196484,
0.007871230132877827,
0.027879955247044563,
0.03382580727338791,
-0.01866856776177883,
0.0052377330139279366,
0.02921426109969616,
0.009591781534254551,
-0.0027988222427666187,
-0.01521576102823019,
-0.014689060859382153,
0.01218431256711483,
-0.013413278385996819,
-0.02262466587126255,
0.011751249432563782,
-0.01566052995622158,
-0.014712470583617687,
-0.011844884604215622,
-0.009591781534254551,
0.004043880850076675,
0.0186802726238966,
-0.016058480367064476,
-0.010885121300816536,
-0.0022296940442174673,
-0.04136345908045769,
-0.08698733150959015,
-0.001765906112268567,
0.014057021588087082,
-0.019300607964396477,
-0.010896825231611729,
-0.003923910669982433,
0.012219426222145557,
0.03209355100989342,
-0.027856547385454178,
0.017978006973862648,
0.05936487391591072,
0.008485713042318821,
-0.013460095971822739,
0.03148492053151131,
-0.00629113195464015,
0.019909238442778587,
-0.008708097040653229,
0.009182126261293888,
-0.0230577290058136,
-0.005477673839777708,
0.017065061256289482,
-0.01717040129005909,
0.004213595297187567,
0.03125083073973656,
-0.00364007824100554,
0.0061623831279575825,
-0.010873416438698769,
-0.022133080288767815,
0.04550682753324509,
-0.00895974226295948,
-0.008497416973114014,
-0.014396450482308865,
-0.010972904041409492,
-0.011803918518126011,
0.01966344378888607,
0.018738795071840286,
-0.006876353174448013,
-0.015051898546516895,
0.0061857919208705425,
0.044102296233177185,
-0.038882121443748474,
-0.03099333494901657,
-0.002276511862874031,
0.03005697950720787,
0.009492293931543827,
0.006888058036565781,
-0.016772450879216194,
-0.009035821072757244,
-0.007256747223436832,
-0.00016843408229760826,
-0.004371604882180691,
-0.03190628066658974,
0.020658321678638458,
-0.007525949273258448,
-0.015028489753603935,
0.01702994666993618,
-0.008526678197085857,
0.00948058906942606,
0.0005705910152755678,
-0.0033386889845132828,
0.007332826033234596,
-0.024345217272639275,
0.002402334474027157,
-0.008386225439608097,
-0.01456031296402216,
-0.01526257861405611,
0.020260371267795563,
-0.01584780029952526,
0.005580087658017874,
-0.019300607964396477,
0.016526656225323677,
0.018083347007632256,
-0.02370147407054901,
0.012277948670089245,
0.006542777176946402,
-0.007578619290143251,
0.03946734219789505,
-0.02120842970907688,
-0.006841239985078573,
-0.011160175316035748,
-0.00902996864169836,
0.0006916587590239942,
0.006607151590287685,
-0.04967360571026802,
0.008052648976445198,
0.001877098111435771,
-0.001841984922066331,
0.0253986157476902,
0.027669275179505348,
-0.007660550065338612,
0.01820039004087448,
-0.027271324768662453,
0.015110420994460583,
0.015145533718168736,
0.028769491240382195,
-0.02069343440234661,
-0.0034966988023370504,
-0.01204385980963707,
0.02055298164486885,
-0.022542735561728477,
-0.01759175956249237,
-0.04595159739255905,
0.014466676861047745,
-0.022519325837492943,
-0.0007384764612652361,
0.02968243695795536,
0.0011214307742193341,
-0.00788293406367302,
0.022730005905032158,
-0.04356389492750168,
-0.00631454074755311,
0.011681022122502327,
0.023771699517965317,
0.003163122572004795,
0.020119916647672653,
-0.010370125994086266,
0.0029568320605903864,
0.009919505566358566,
0.021395700052380562,
-0.03504306823015213,
0.0010424258653074503,
0.017896074801683426,
-0.013565436005592346,
-0.03808622062206268,
0.043119125068187714,
0.017018243670463562,
-0.027669275179505348,
0.004918787162750959,
-0.010276490822434425,
-0.007847821339964867,
0.02299920655786991,
-0.029893117025494576,
0.003207014175131917,
0.011288924142718315,
0.008784175850450993,
0.001338694361038506,
0.03628373518586159,
-0.037805311381816864,
-0.003719083033502102,
-0.017463011667132378,
0.0015449848724529147,
-0.00024030660279095173,
-0.016924608498811722,
-0.020260371267795563,
0.01260567270219326,
-0.0035464426036924124,
-0.0016488617984578013,
0.031110377982258797,
-0.02059979923069477,
0.0005021932302042842,
0.0029202555306255817,
-0.008585200645029545,
-0.0030753393657505512,
0.03099333494901657,
-0.027856547385454178,
0.0007443286594934762,
0.0235610194504261,
0.015730755403637886,
0.008128727786242962,
0.039678022265434265,
0.0180131196975708,
-0.014174066483974457,
0.001369418459944427,
-0.0015113346744328737,
0.01474758330732584,
-0.035066477954387665,
-0.011201140470802784,
0.0919031947851181,
-0.013717593625187874,
-0.03185946121811867,
0.01811845973134041,
-0.001762980013154447,
-0.035487834364175797,
0.010615918785333633,
-0.022648073732852936,
0.021887285634875298,
-0.034130122512578964,
0.019031405448913574,
-0.005217250436544418,
0.03155514597892761,
0.003531812224537134,
0.026592466980218887,
-0.00470518134534359,
0.02851199544966221,
0.040614377707242966,
0.0010643716668710113,
-0.006425732746720314,
0.002809063531458378,
0.019558103755116463,
0.013518618419766426,
0.02366635948419571,
-0.02290557138621807,
0.015613711439073086,
-0.023443976417183876,
-0.014103840105235577,
-0.015367918647825718,
-0.0009963397169485688,
0.01411554403603077,
-0.0042311521247029305,
0.008825141005218029,
0.00797071773558855,
-0.006226757541298866,
-0.028956763446331024,
-0.017135286703705788,
-0.000568030693102628,
-0.0017161621944978833,
0.02318647876381874,
-0.008977298624813557,
-0.002806137315928936,
-0.01175710093230009,
-0.0020175513345748186,
0.03707963973283768,
0.022554438561201096,
-0.019920941442251205,
0.007666402496397495,
0.02935471385717392,
-0.028722673654556274,
0.0044359792955219746,
0.0025676595978438854,
-0.000910019560251385,
-0.009310875087976456,
-0.030408112332224846,
-0.024626122787594795,
0.003125083167105913,
-0.012500332668423653,
0.01899629272520542,
-0.02243739552795887,
-0.014373041689395905,
0.025562478229403496,
0.019792193546891212,
-0.010744667612016201,
-0.0016152114840224385
] | 2025-01-06 | 1 | 39757684 | [
"cancer cells",
"cancer treatment paradigms",
"severe side effects",
"conventional treatments",
"ongoing research",
"solid tumours",
"Cancer",
"CAR T-cell therapy",
"challenges",
"high costs",
"remarkable success",
"CAR T-cells",
"patients",
"renewed optimism",
"CAR T-cell (chimeric antigen receptor T-cell) treatment",
"manufacturing variability",
"hematologic malignancies",
"advancements",
"radiation",
"death",
"chemotherapy",
"fightingcancer",
"hope",
"a significant health challenge",
"surgery",
"medicine",
"a novel immunotherapy method",
"social and economic burdens",
"a leading cause",
"the treatment"
] | [
"CAR T-cell",
"Cancer",
"immunotherapy",
"malignancy",
"oncology.",
"side effects",
"treatment",
"tumour"
] | 0 | 10.2174/0113816128336391241107112957 | [
"Barjasteh",
"Saebi",
"Mahmoudi",
"Kheder",
"Hashemy",
"Forouzanfar",
"Esmaeili"
] | [
"Immunology Department, Mashhad University of Medical Sciences, Faculty of Medicine, Mashhad, Iran.",
"Immunology Department, Mashhad University of Medical Sciences, Faculty of Medicine, Mashhad, Iran.",
"Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.\nImmunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.",
"Medical Laboratory Science Department, College of Science, University of Raparin, Rania, Sulaymaniyah, Iraq.\nDepartment of Medical Analysis, Faculty of Applied Science, Tishk International University, Erbil, Iraq.",
"Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.",
"Neuroscience Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.\nDepartment of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.",
"Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.\nImmunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran."
] | [
"39757684"
] | [] | 9.752551 | 3.954268 |
39757079 | 76 | Chimeric antigen receptor-T cells targeting AFP-GPC3 mediate increased antitumor efficacy in hepatocellular carcinoma. | As a novel immunotherapy, chimeric antigen receptor T (CAR-T) cell technology is successful in treating hematologic malignancies, and exhibits potential benefits in partial solid tumors. Therapies targeting one antigen have some weaknesses, and dual-targeted CAR-T cells may be a better option. Alpha-fetoprotein (AFP) and glypican-3 (GPC3) are both highly expressed in hepatocellular carcinoma (HCC) and serve as important markers. Our study aimed to compare the cytotoxicity effect of AFP and GPC3 dual-targeted CAR-T cells on HCC cells in vitro and its therapeutic effects on a SCID xenograft model with those of single-targeted CAR-T cells.
pLVX lentivirus vectors loaded with AFP CAR, GPC3 CAR, or AFP-GPC3 CAR constructs were transfected into human T lymphocytes. Control T, AFP CAR-T, GPC3 CAR-T, and AFP-GPC3 CAR-T cells were used as effector cells, and HLE (AFP
AFP and GPC3 were highly expressed in Huh-7 cells. AFP-GPC3 CAR-T cells exerted significant cell-killing effects on the HCC cells that expressed specific targeting antigen molecules (AFP and GPC3). Besides, AFP-GPC3 CAR-T cells better promoted Th cytokine secretion by Huh-7 cells than AFP CAR-T and GPC3 CAR-T cells. In vivo results suggested that AFP-GPC3 CAR-T cells better inhibited the growth of Huh-7 cell (AFP
AFP and GPC3 dual-targeted CAR-T cells showed better anti-tumor effects in HCC than AFP or GPC3 single-targeted CAR-T cells. | [
-0.013530995696783066,
-0.02156430296599865,
0.07085908204317093,
0.0667559802532196,
-0.027937931939959526,
-0.027269450947642326,
-0.015720849856734276,
0.02233651466667652,
0.019420551136136055,
-0.019662586972117424,
0.011150969192385674,
-0.009133998304605484,
-0.05555314943194389,
-0.0011006899876520038,
-0.0333779901266098,
-0.045525919646024704,
0.02595553733408451,
-0.02098802663385868,
0.006102778483182192,
0.0006104939384385943,
0.03353935107588768,
0.00510005559772253,
0.0026364694349467754,
0.012839462608098984,
-0.02164498157799244,
-0.007895001210272312,
0.05854979157447815,
0.0010200111428275704,
-0.03125729039311409,
-0.0010149687295779586,
0.05191107466816902,
-0.015939835458993912,
-0.018164265900850296,
-0.032824765890836716,
-0.03692786023020744,
0.036950912326574326,
0.03296307101845741,
0.027776574715971947,
-0.038633640855550766,
-0.012977768667042255,
0.05684401094913483,
0.031879670917987823,
0.003786143148317933,
0.009243491105735302,
-0.030519654974341393,
-0.015985937789082527,
-0.0085461949929595,
-0.0347149558365345,
-0.005656163673847914,
0.020826667547225952,
-0.026854529976844788,
0.023950092494487762,
-0.008413651026785374,
0.06150033324956894,
-0.056336887180805206,
0.02779962494969368,
-0.033815961331129074,
-0.021368369460105896,
0.020112084224820137,
0.013381163589656353,
-0.014464564621448517,
-0.02551756612956524,
0.04416590556502342,
-0.0206307340413332,
-0.06375934183597565,
-0.0027329958975315094,
-0.040639087557792664,
-0.021956171840429306,
-0.003780380357056856,
0.023373814299702644,
-0.015801528468728065,
0.003379867412149906,
0.03455359861254692,
-0.005935658235102892,
0.0564751923084259,
-0.011571652255952358,
-0.0017302731284871697,
0.03582140803337097,
0.024111449718475342,
-0.03376986086368561,
0.02283211424946785,
0.010759100317955017,
-0.0035642762668430805,
-0.006598377134650946,
0.01179063692688942,
-0.05569145455956459,
0.025886384770274162,
-0.006148880813270807,
-0.050942931324243546,
-0.023062624037265778,
-0.0030773216858506203,
0.03245594725012779,
-0.046471014618873596,
0.03033524751663208,
-0.026831479743123055,
0.019339872524142265,
0.023373814299702644,
-0.04946766048669815,
0.009589257650077343,
0.009952312335371971,
0.04110011085867882,
0.020676836371421814,
-0.036190226674079895,
0.013162177987396717,
0.018763594329357147,
0.014291681349277496,
-0.03294002264738083,
0.02317788079380989,
0.02595553733408451,
-0.01894800364971161,
0.08943826705217361,
0.00606820173561573,
-0.030634911730885506,
0.07385572046041489,
-0.0012209878768771887,
-0.047807980328798294,
-0.040892649441957474,
-0.024457216262817383,
0.012747257947921753,
0.03411562740802765,
-0.022809062153100967,
0.04319775849580765,
0.029459305107593536,
-0.07136620581150055,
0.028260648250579834,
-0.004592931363731623,
0.06652547419071198,
-0.04541066661477089,
-0.037711597979068756,
-0.07671406120061874,
0.011871316470205784,
0.0035585134755820036,
-0.010891644284129143,
-0.016320178285241127,
-0.030773216858506203,
0.011444870382547379,
-0.023454492911696434,
-0.022889740765094757,
-0.03916381672024727,
-0.0031580005306750536,
0.019662586972117424,
-0.012643528170883656,
0.00011867714783875272,
0.010695709846913815,
-0.04349742457270622,
-0.037273626774549484,
-0.03277866169810295,
-0.005846335086971521,
-0.0064024426974356174,
0.05997896194458008,
-0.044281162321567535,
0.017334425821900368,
0.069429911673069,
-0.0033280025236308575,
-0.044788286089897156,
0.0021884136367589235,
0.007560760714113712,
0.04001670703291893,
-0.04960596561431885,
-0.06827735900878906,
-0.03317053243517876,
0.02123006246984005,
-0.03128034248948097,
-0.030312195420265198,
0.03881805017590523,
-0.010810965672135353,
-0.022140581160783768,
0.03296307101845741,
-0.07694456726312637,
0.0321793332695961,
-0.03561394661664963,
-0.05458500236272812,
-0.08888503909111023,
-0.008217716589570045,
-0.03427698463201523,
-0.04845340922474861,
0.03849533572793007,
0.006558037828654051,
-0.04188384860754013,
-0.03049660474061966,
0.014683550223708153,
0.0431286059319973,
0.04153808206319809,
0.004080044571310282,
-0.022106004878878593,
0.023396866396069527,
-0.0023598563857376575,
0.01920156553387642,
-0.03985534980893135,
0.005172090604901314,
0.055230434983968735,
0.01961648464202881,
0.0449957475066185,
0.04289809614419937,
-0.01002722792327404,
-0.019443601369857788,
0.033401042222976685,
0.056751806288957596,
-0.005287345964461565,
-0.0033769861329346895,
0.020780565217137337,
0.011110629886388779,
-0.030796268954873085,
0.005540907848626375,
-0.020780565217137337,
-0.031902723014354706,
0.003155119251459837,
0.033585451543331146,
-0.002604774199426174,
0.0016452722484245896,
0.06933770328760147,
0.009191625751554966,
-0.01373845525085926,
0.014084221795201302,
-0.03531428426504135,
-0.02779962494969368,
-0.05652129650115967,
0.015985937789082527,
0.02401924505829811,
0.008315684273838997,
0.0017590869683772326,
-0.006367866415530443,
-0.0005867225117981434,
0.00909365899860859,
-0.02789182960987091,
-0.01558254286646843,
-0.0046592033468186855,
-0.022532450035214424,
0.012666579335927963,
-0.04683983325958252,
0.020365646108984947,
0.01618187129497528,
0.0013420061441138387,
-0.029851173982024193,
-0.032478999346494675,
-0.04573338106274605,
0.03008168376982212,
0.011410294100642204,
0.01895952969789505,
-0.007514658384025097,
-0.009681461378932,
0.020573105663061142,
0.03167220950126648,
-0.03932517394423485,
-0.037273626774549484,
-0.032986123114824295,
0.012101827189326286,
-0.07459335774183273,
0.018844272941350937,
0.014234053902328014,
0.017979856580495834,
-0.014476090669631958,
-0.004036823753267527,
-0.015294404700398445,
0.00926654227077961,
0.038380078971385956,
0.02284364029765129,
-0.036098022013902664,
0.014925586991012096,
-0.06126982346177101,
0.00589531846344471,
0.025148749351501465,
-0.05172666534781456,
-0.05200327932834625,
-0.037527188658714294,
0.02147209830582142,
-0.020999550819396973,
0.0449957475066185,
0.006143117789179087,
-0.00638515455648303,
0.0345766507089138,
0.022935843095183372,
0.07652965188026428,
-0.021287690848112106,
-0.04319775849580765,
0.004454624839127064,
-0.03741193562746048,
0.03810346871614456,
-0.008113986812531948,
0.0006803675787523389,
-0.0399245023727417,
0.010367232374846935,
-0.03411562740802765,
-0.0091801006346941,
-0.009110947139561176,
0.0011907333973795176,
0.008500092662870884,
-0.019166989251971245,
-0.007111263927072287,
-0.024365011602640152,
0.018417827785015106,
-0.04771577566862106,
-0.021967697888612747,
-0.0044488622806966305,
-0.00010454034054419026,
0.036190226674079895,
-0.03234069421887398,
-0.02551756612956524,
-0.04038552567362785,
0.009727563709020615,
-0.04589473828673363,
0.0042846230790019035,
-0.03280171379446983,
-0.0431286059319973,
0.020699886605143547,
0.0195588581264019,
0.0025701976846903563,
0.018763594329357147,
0.004304792732000351,
0.043451324105262756,
0.010182823054492474,
-0.029297947883605957,
0.019109360873699188,
0.01559406891465187,
-0.015144572593271732,
0.02992032654583454,
0.008672975935041904,
-0.06306780874729156,
-0.03713532164692879,
-0.017830025404691696,
-0.002282058820128441,
-0.01930529624223709,
-0.05223379284143448,
-0.003137830877676606,
-0.004399878438562155,
-0.030012531206011772,
0.019351398572325706,
0.003593090223148465,
-0.00879975687712431,
-0.004771577659994364,
0.031049830839037895,
-0.02551756612956524,
0.030358297750353813,
-0.023523647338151932,
-0.001314633060246706,
-0.009087895974516869,
-0.059517938643693924,
-0.023442968726158142,
0.017933756113052368,
0.006684818770736456,
0.013196754269301891,
0.045018795877695084,
-0.04077739641070366,
0.051772769540548325,
-0.0010877237655222416,
-0.02494128979742527,
0.012701155617833138,
0.05112733691930771,
0.02899828366935253,
0.03268645703792572,
-0.013277432881295681,
0.01727679930627346,
0.006431256886571646,
0.015813054516911507,
-0.008943826891481876,
0.014741177670657635,
-0.04423505812883377,
0.008868910372257233,
0.002567316172644496,
0.032893918454647064,
0.004996325820684433,
0.013265907764434814,
-0.037688545882701874,
0.015490339137613773,
0.03319358453154564,
0.027177246287465096,
-0.015398134477436543,
0.0068749901838600636,
-0.011029951274394989,
-0.02427280694246292,
-0.012021148577332497,
-0.0237656831741333,
0.023235507309436798,
-0.011450633406639099,
-0.002234515966847539,
0.014141849242150784,
0.02267075702548027,
0.013554046861827374,
0.02982812188565731,
-0.037965159863233566,
0.057258930057287216,
-0.038126517087221146,
0.016458485275506973,
-0.05453890189528465,
-0.0018930715741589665,
0.007312961388379335,
0.030704064294695854,
-0.025471465662121773,
-0.055230434983968735,
0.025056544691324234,
0.013796082697808743,
-0.015017791651189327,
0.019754791632294655,
-0.025840282440185547,
-0.01711544208228588,
0.03891025483608246,
-0.013634725473821163,
0.07095128297805786,
0.04239097237586975,
0.019339872524142265,
-0.013554046861827374,
0.009502816013991833,
-0.03042745031416416,
-0.020930398255586624,
0.006534986663609743,
0.006085490342229605,
0.016550689935684204,
0.03916381672024727,
0.03718142211437225,
0.003529699519276619,
-0.003953263629227877,
0.017484258860349655,
0.033585451543331146,
0.03125729039311409,
0.027592165395617485,
-0.018763594329357147,
-0.03109593316912651,
0.04534151405096054,
-0.010470962151885033,
0.026186048984527588,
0.016493061557412148,
-0.02267075702548027,
0.02308567613363266,
-0.003688175929710269,
0.015144572593271732,
-0.017887653782963753,
0.02872166968882084,
0.001888749422505498,
0.013865236192941666,
-0.0475313663482666,
-0.023362288251519203,
0.032156284898519516,
-0.00017126246530096978,
-0.008350260555744171,
-0.0028741839341819286,
0.016815777868032455,
-0.007589574437588453,
0.010413333773612976,
-0.04826900362968445,
0.0862572118639946,
-0.007531946524977684,
0.01171572133898735,
0.036259379237890244,
-0.04610219970345497,
-0.00977942906320095,
-0.03252509981393814,
0.027177246287465096,
0.01516762375831604,
-0.04624050483107567,
-0.005975997541099787,
-0.034253932535648346,
0.0021567184012383223,
-0.008453990332782269,
0.000016567977581871673,
-0.02925184555351734,
0.019685639068484306,
0.03427698463201523,
-0.03446139395236969,
0.02267075702548027,
0.010326892137527466,
0.051680564880371094,
-0.052787017077207565,
-0.035844460129737854,
-0.03024304285645485,
-0.00012155852891737595,
0.03118813782930374,
0.039993658661842346,
-0.005463110748678446,
0.012378440238535404,
-0.022232785820961,
0.02367347851395607,
0.008696027100086212,
-0.046378813683986664,
0.029597612097859383,
-0.022601602599024773,
0.03522207960486412,
0.0050856489688158035,
-0.008442465215921402,
-0.010171297937631607,
-0.012539798393845558,
-0.008511618711054325,
-0.05398567393422127,
-0.01453371811658144,
-0.026693172752857208,
0.0029332523699849844,
0.05223379284143448,
0.006903804372996092,
-0.0010070449206978083,
0.010211637243628502,
0.051680564880371094,
0.00638515455648303,
0.0002159239666070789,
-0.0022935844026505947,
-0.010309603996574879,
0.017553411424160004,
-0.01904020830988884,
0.02056158147752285,
-0.01389981247484684,
-0.01153707504272461,
0.036121074110269547,
0.02055005542933941,
0.01686187833547592,
0.020434798672795296,
-0.022520923987030983,
0.05509212613105774,
0.03310137987136841,
0.02317788079380989,
0.02535620890557766,
0.014211002737283707,
0.0372505746781826,
0.001302387099713087,
0.009450950659811497,
0.00960078276693821,
-0.031879670917987823,
-0.02720029652118683,
-0.02189854346215725,
-0.043774038553237915,
-0.000883865577634424,
0.001544423634186387,
-0.0163547545671463,
-0.01625102572143078,
0.007952629588544369,
-0.023950092494487762,
-0.013242856599390507,
-0.0034922414924949408,
-0.008903486654162407,
-0.022106004878878593,
-0.04817679896950722,
-0.03229459002614021,
-0.054723311215639114,
0.004080044571310282,
-0.02729250118136406,
-0.003627666737884283,
-0.01710391603410244,
-0.019351398572325706,
0.02283211424946785,
-0.02434196136891842,
0.010511301457881927,
-0.008863147348165512,
-0.03556784614920616,
0.034922417253255844,
-0.03741193562746048,
0.018579186871647835,
-0.014568294398486614,
0.02030801773071289,
-0.009122472256422043,
0.03489936515688896,
-0.03983230143785477,
0.007238045334815979,
-0.009197388775646687,
0.020780565217137337,
-0.06191525235772133,
0.011669619008898735,
0.002387229586020112,
0.026831479743123055,
-0.01567474752664566,
0.011231647804379463,
-0.029874224215745926,
-0.007042110897600651,
-0.001797985751181841,
0.004299030173569918,
0.019259193912148476,
0.0035037670750170946,
-0.04213741049170494,
-0.017795449122786522,
0.02846810780465603,
0.015317455865442753,
-0.005612942855805159,
-0.015790002420544624,
0.029620662331581116,
0.008281107060611248,
0.020688362419605255,
0.009929261170327663,
-0.022601602599024773,
0.03540648892521858,
0.017979856580495834,
-0.05297142639756203,
0.020019879564642906,
0.0034922414924949408,
-0.01074757520109415,
-0.029390152543783188,
-0.017818499356508255,
0.004405641462653875,
0.018590711057186127,
0.01251674722880125,
-0.013069973327219486,
-0.03310137987136841,
-0.0006090532406233251,
-0.014395411126315594,
0.009929261170327663,
0.022762959823012352,
-0.022762959823012352,
0.022935843095183372,
-0.010142483748495579,
-0.05283312126994133,
0.014729652553796768,
0.014268630184233189,
-0.002858336316421628,
-0.014925586991012096,
-0.004221232607960701,
-0.014798806048929691,
0.01895952969789505,
-0.0335162989795208,
-0.03224848955869675,
-0.02738470584154129,
0.019524281844496727,
0.020953448489308357,
-0.022855164483189583,
0.0010740371653810143,
0.00475717056542635,
0.04534151405096054,
0.009790954180061817,
-0.019259193912148476,
0.012251659296452999,
0.00421546958386898,
-0.004745644982904196,
0.009007217362523079,
-0.006218033842742443,
0.0038236011750996113,
-0.034668851643800735,
-0.005298871546983719,
-0.009053319692611694,
-0.01348489336669445,
0.025886384770274162,
-0.0040224166586995125,
-0.025494515895843506,
-0.04061603546142578,
0.0018512913957238197,
0.010171297937631607,
-0.014118798077106476,
-0.027361655607819557,
-0.019063258543610573,
-0.005474635865539312,
0.022140581160783768,
0.014268630184233189,
-0.05504602566361427,
0.017126966267824173,
-0.022947369143366814,
-0.008793994784355164,
0.013611674308776855,
-0.01877512037754059,
0.06136202812194824,
-0.01251674722880125,
-0.04988257959485054,
0.009341457858681679,
0.006431256886571646,
0.0007621269905939698,
-0.012954717501997948,
0.00678278598934412,
-0.02181786485016346,
0.007157366257160902,
-0.020261915400624275,
0.004212588537484407,
0.001253403490409255,
0.02064226008951664,
-0.008373311720788479,
0.02551756612956524,
0.012920141220092773,
-0.0022633299231529236,
0.05785825848579407,
-0.036512941122055054,
0.03024304285645485,
-0.022290412336587906,
0.0013823455665260553,
-0.0003864660975523293,
-0.027015889063477516,
0.012124878354370594,
0.02367347851395607,
-0.020607681944966316,
-0.003446139395236969,
0.07238045334815979,
-0.004947341978549957,
0.0004639033868443221,
-0.024111449718475342,
-0.020019879564642906,
0.013173703104257584,
0.013185229152441025,
-0.02535620890557766,
-0.03893330693244934,
0.012551323510706425,
-0.010666896589100361,
0.02048090100288391,
-0.04718559980392456,
-0.04213741049170494,
-0.0008925097645260394,
0.01532898098230362,
-0.0012209878768771887,
-0.016193397343158722,
0.008822808042168617,
-0.02913658879697323,
-0.016412382945418358,
-0.00880551990121603,
-0.004431573674082756,
-0.01846393011510372,
-0.012482170015573502,
0.002465026918798685,
-0.010540114715695381,
-0.01710391603410244,
-0.032064080238342285,
-0.02906743623316288,
0.0009695868939161301,
-0.010903170332312584,
0.03091152384877205,
-0.01137571781873703,
0.014383886009454727,
-0.023293135687708855,
-0.023558223620057106,
0.0007289909990504384,
0.008863147348165512,
0.0237656831741333,
0.010205874219536781,
-0.00044481418444775045,
-0.016400856897234917,
-0.043105557560920715,
0.007140078116208315,
0.014015068300068378,
0.00242324685677886,
0.023535171523690224,
0.0023656191769987345,
0.01372692920267582,
-0.014291681349277496,
0.028675567358732224,
0.012067250907421112,
0.019996829330921173,
0.022866690531373024,
-0.020031405612826347,
-0.05112733691930771,
0.035936664789915085,
-0.01591678336262703,
-0.007871950045228004,
0.01162927970290184,
-0.0468628853559494,
-0.02627825364470482,
-0.02925184555351734,
-0.02257855236530304,
0.01886732503771782,
-0.03296307101845741,
-0.019996829330921173,
-0.022290412336587906,
-0.008459753356873989,
0.05121954157948494,
-0.02157582901418209,
-0.02148362435400486,
-0.009548918344080448,
-0.060947105288505554,
0.03376986086368561,
0.04458082467317581,
0.021011076867580414,
0.00193773303180933,
-0.014141849242150784,
0.008448228240013123,
0.007324486970901489,
-0.017899177968502045,
-0.01534050703048706,
-0.019247667863965034,
-0.024641625583171844,
-0.014798806048929691,
0.014291681349277496,
0.011940469034016132,
-0.008707553148269653,
0.005295990034937859,
-0.0018628169782459736,
0.00558412866666913,
0.004996325820684433,
-0.012159454636275768,
0.014556769281625748,
0.00931264366954565,
0.004526659846305847,
-0.02713114395737648,
0.0049761561676859856,
0.008736366406083107,
0.000012516026799858082,
0.01496016327291727,
-0.04269063472747803,
-0.013265907764434814,
0.021022602915763855,
-0.026139946654438972,
-0.0020659547299146652,
0.010136720724403858,
0.032225437462329865,
-0.014522192999720573,
-0.0013391247484833002,
-0.014902535825967789,
-0.015559491701424122,
-0.005710910074412823,
-0.0289060790091753,
0.035683102905750275,
0.015547966584563255,
-0.043681833893060684,
-0.011248936876654625,
0.011053002439439297,
0.04100790619850159,
-0.022947369143366814,
0.05158836022019386,
-0.01558254286646843,
0.03607496991753578,
0.035775307565927505,
-0.11239715665578842,
-0.025494515895843506,
0.017230696976184845,
-0.017495784908533096,
-0.01718459464609623,
0.006269899196922779,
0.0011648008367046714,
-0.015363557264208794,
0.0033452908974140882,
-0.021714136004447937,
0.04271368682384491,
-0.010349943302571774,
0.01778392307460308,
-0.022797537967562675,
0.009376035071909428,
0.002313754055649042,
-0.016458485275506973,
-0.06629496067762375,
0.023235507309436798,
0.011237410828471184,
0.006494647357612848,
0.031464751809835434,
0.029297947883605957,
0.01894800364971161,
0.018314098939299583,
0.03065796196460724,
-0.029943378642201424,
-0.009295355528593063,
-0.025494515895843506,
0.003869703272357583,
-0.0019535806495696306,
0.001774934702552855,
-0.007001771591603756,
0.030634911730885506,
-0.00881128292530775,
0.004143435042351484,
0.0085461949929595,
-0.008442465215921402,
0.0156862735748291,
0.018602237105369568,
0.0040742820128798485,
-0.012459118850529194,
0.004777340218424797,
0.015133046545088291,
-0.0055178566835820675,
0.013415739871561527,
-0.006079727318137884,
0.005535145290195942,
0.009716038592159748,
-0.0017216289415955544,
0.012908615171909332,
-0.026670122519135475,
-0.025333158671855927,
0.014545243233442307,
-0.005284464452415705,
-0.020446324720978737,
0.003028338076546788,
0.0024261281359940767,
-0.0000859914071043022,
-0.001835443777963519,
-0.05679791048169136,
0.05730503425002098,
0.037365831434726715,
-0.024318909272551537,
-0.027015889063477516,
-0.005134632345288992,
-0.049744270741939545,
0.009716038592159748,
-0.05449279770255089,
-0.011185546405613422,
0.0022431600373238325,
0.01978936791419983,
-0.014937112107872963,
0.015156097710132599,
0.013185229152441025,
0.020596157759428024,
-0.010718761011958122,
0.010447910986840725,
-0.00888619851320982,
0.03423088416457176,
-0.002300787949934602,
-0.029597612097859383,
-0.027753524482250214,
0.02148362435400486,
-0.015017791651189327,
-0.014337783679366112,
0.0456642284989357,
-0.00421546958386898,
0.0190286822617054,
-0.028698619455099106,
-0.0007063000812195241,
-0.013358112424612045,
-0.013162177987396717,
0.027661319822072983,
0.002362737664952874,
-0.014856433495879173,
-0.012539798393845558,
-0.001380904926918447,
-0.010782151482999325,
-0.01878664642572403,
0.03637463599443436,
-0.051864974200725555,
0.011871316470205784,
-0.035867512226104736,
-0.04506490007042885,
-0.022855164483189583,
0.05366295948624611,
-0.011554363183677197,
-0.004480557516217232,
-0.0257019754499197,
0.027684370055794716,
0.004054111894220114,
0.0030715588945895433,
-0.02789182960987091,
-0.003780380357056856,
0.019512755796313286,
0.03556784614920616,
0.010246213525533676,
-0.005736842285841703,
-0.010505538433790207,
0.05117344111204147,
0.010643845424056053,
0.025886384770274162,
-0.009076369926333427,
-0.009652648121118546,
0.00986010767519474,
-0.025125699117779732,
0.047139499336481094,
0.003431732300668955,
0.030104735866189003,
0.018971053883433342,
0.008857385255396366,
0.003051389241591096,
-0.01313912682235241,
-0.018752070143818855,
0.023903990164399147,
0.015732375904917717,
0.006840413901954889,
-0.00043977174209430814,
0.033493246883153915,
-0.004267334938049316,
-0.014672025106847286,
-0.01686187833547592,
-0.009888921864330769,
0.013185229152441025,
-0.016216447576880455,
-0.03303222358226776,
0.015294404700398445,
-0.009704512543976307,
-0.017484258860349655,
-0.027684370055794716,
0.02579418011009693,
0.010983848944306374,
0.00931264366954565,
-0.0077566951513290405,
0.030289145186543465,
0.050850726664066315,
-0.018072061240673065,
-0.02779962494969368,
0.025678925216197968,
0.00735330069437623,
0.038126517087221146,
-0.03280171379446983,
-0.0009537392179481685,
0.020457850769162178,
-0.00825805589556694,
0.0006547952652908862,
0.0019478178583085537,
0.024549420922994614,
0.043704885989427567,
0.014245579019188881,
-0.06961432099342346,
0.04859171807765961,
0.015478813089430332,
-0.005520738195627928,
0.03985534980893135,
0.001992479432374239,
0.008511618711054325,
-0.011940469034016132,
0.032156284898519516,
-0.03918686881661415,
-0.003907161299139261,
0.01870596781373024,
0.010165534913539886,
0.03835703060030937,
-0.015640171244740486,
0.026485713198781013,
-0.033839013427495956,
0.05029749870300293,
-0.007514658384025097,
-0.013876762241125107,
-0.007883476093411446,
0.007163129281252623,
0.034507494419813156,
0.02872166968882084,
-0.001120139379054308,
0.007272621616721153,
0.011514023877680302,
-0.05822707712650299,
-0.0038524148985743523,
-0.006408205721527338,
0.03250205144286156,
0.019086310639977455,
-0.006241085007786751,
0.0011828095884993672,
-0.00629871292039752,
0.009744851849973202,
-0.02966676466166973,
-0.003621903946623206,
0.04488049075007439,
0.007537709549069405,
0.03296307101845741,
-0.04919104650616646,
0.007485844660550356,
-0.0029174047522246838,
0.021449048072099686,
0.009583494625985622,
0.01818731799721718,
-0.031718313694000244,
-0.024733830243349075,
-0.046978142112493515,
0.006189220119267702,
-0.017968332394957542,
-0.019339872524142265,
0.0018498507561162114,
-0.00843093916773796,
0.026232151314616203,
0.005370906088501215,
0.0007592455949634314,
0.014891009777784348,
-0.04186079651117325,
0.012470644898712635,
0.03153390437364578,
0.021887019276618958,
-0.013842185027897358,
0.007001771591603756,
-0.01293166633695364,
-0.02046937681734562,
0.015432710759341717,
-0.018832748755812645,
0.05735113471746445,
0.016700521111488342,
0.005200904328376055,
-0.021806340664625168,
-0.0064024426974356174,
0.006310238502919674,
0.030266093090176582,
-0.050066988915205,
0.005053953733295202,
-0.005987523123621941,
0.0022244311403483152,
-0.014833382330834866,
0.024065347388386726,
0.0475313663482666,
0.009675699286162853,
0.007105501368641853,
0.009952312335371971,
0.04354352504014969,
0.02046937681734562,
0.006425493862479925,
-0.01754188723862171,
0.010689947754144669,
0.000018830316548701376,
-0.01686187833547592,
0.047485265880823135,
-0.03328578919172287,
-0.020826667547225952,
-0.02299347147345543,
0.018152739852666855,
0.023811785504221916,
0.01770324446260929,
0.021806340664625168,
-0.025148749351501465,
0.01313912682235241,
-0.020826667547225952,
-0.04660932347178459,
0.02367347851395607,
0.00258028251118958,
0.014326258562505245,
0.019674113020300865,
-0.019063258543610573,
0.04110011085867882,
-0.020181236788630486,
0.03469190374016762,
0.007906527258455753,
0.007797034457325935,
-0.0069268555380403996,
-0.013346586376428604,
0.00181671476457268,
-0.0011114951921626925,
-0.014925586991012096,
-0.018314098939299583,
-0.0021970579400658607,
-0.014764228835701942,
-0.020676836371421814,
-0.016700521111488342,
0.03243289515376091,
-0.02157582901418209,
-0.008580771274864674,
-0.026416560634970665,
0.01827952265739441,
0.02080361731350422,
-0.0019031564006581903,
-0.030796268954873085,
0.019489703699946404,
-0.033308837562799454,
-0.0008946707821451128,
-0.047577470541000366,
0.040892649441957474,
-0.020077507942914963,
-0.03312442824244499,
0.006857702042907476,
-0.023880938068032265,
-0.0013067092513665557,
0.027430808171629906,
0.014545243233442307,
-0.007457030471414328,
0.007652964908629656,
-0.018901901319622993,
-0.004437336698174477,
-0.005638875067234039,
0.0015790002653375268,
0.014049644581973553,
-0.012574374675750732,
-0.008148564025759697,
-0.0172883253544569,
0.03750414028763771,
-0.008407888934016228,
-0.010390282608568668,
-0.021633457392454147,
0.01753036119043827,
-0.01575542613863945,
0.01074181217700243,
0.005368024576455355,
-0.02248634770512581,
0.023316187784075737,
-0.017922230064868927,
-0.025079596787691116,
-0.0021149383392184973,
-0.004921409767121077,
-0.01996225118637085,
0.013461842201650143,
0.006840413901954889,
0.014049644581973553,
0.011225885711610317,
0.003238679375499487,
-0.007895001210272312,
-0.01437236089259386,
-0.02141447179019451,
-0.010251976549625397,
0.05679791048169136,
-0.00880551990121603,
-0.016377806663513184,
0.03227153792977333,
0.010989611968398094,
0.01040757168084383,
-0.006033625453710556,
0.01962801069021225,
0.01499474048614502,
-0.020918872207403183,
-0.014971689321100712,
0.021933121606707573,
0.02351212128996849,
-0.020492427051067352,
0.006679056212306023,
0.01196352019906044,
-0.01837172545492649,
-0.035268183797597885,
-0.0128855649381876,
-0.032893918454647064,
0.008183140307664871,
0.02359279990196228,
-0.01761103980243206,
-0.022186683490872383,
-0.021702609956264496,
0.013093024492263794,
0.029782019555568695,
0.018890375271439552,
-0.014164900407195091,
0.003446139395236969,
0.02554061822593212,
-0.034507494419813156,
-0.0052787018939852715,
-0.009255016222596169,
-0.005151920486241579,
-0.03169526159763336,
-0.04674762859940529,
-0.019420551136136055,
0.004806154407560825,
-0.0044517433270812035,
-0.011611991561949253,
-0.0071227895095944405,
0.017657142132520676,
0.011727246455848217,
-0.036028869450092316,
-0.030266093090176582,
0.0016755267279222608,
0.010926221497356892,
-0.008482804521918297,
-0.0028914723079651594,
-0.018498506397008896,
0.009260779246687889,
-0.01323133148252964,
0.005708028562366962,
0.021172434091567993,
0.05200327932834625,
-0.00686346460133791,
0.014499141834676266,
-0.01305844821035862,
0.001913241227157414,
-0.008367548696696758,
-0.009041793644428253,
-0.04282894358038902,
-0.009450950659811497,
-0.02105717919766903,
-0.002949099987745285,
0.006448545027524233,
-0.008753654547035694,
-0.048222899436950684,
0.003247323678806424,
-0.004071400500833988,
0.005633112508803606,
0.017034761607646942,
0.0047975098714232445,
-0.011364191770553589,
-0.008592297323048115,
-0.009623833931982517,
-0.01056892890483141,
-0.0345766507089138,
0.04441946744918823,
0.008678738959133625,
0.00030200541368685663,
-0.011398768983781338,
-0.021264638751745224,
-0.051680564880371094,
0.021276164799928665,
-0.007935340516269207,
0.013680827803909779,
-0.029782019555568695,
0.010470962151885033,
-0.013542520813643932,
0.003051389241591096,
0.06841566413640976,
0.014914060942828655,
0.013427264988422394,
-0.01972021535038948,
-0.002087565138936043,
0.0021956171840429306,
0.028790822252631187,
0.015490339137613773,
0.04333606734871864,
0.01462592277675867,
0.0017331545241177082,
-0.01786460168659687,
-0.00943942554295063,
-0.004417167045176029,
-0.028929129242897034,
0.0012490814551711082,
0.007076687645167112,
0.014337783679366112,
-0.029551509767770767,
-0.005068360362201929,
0.004520896822214127,
0.015006265603005886,
0.004644796717911959,
0.029459305107593536,
-0.010615031234920025,
0.005538026802241802,
0.0043653021566569805,
0.029966428875923157,
0.00419241888448596,
-0.004218351095914841,
0.02611689642071724,
0.01083401683717966,
0.03897940739989281,
-0.018314098939299583,
0.03950958326458931,
-0.006961431819945574,
0.02611689642071724,
-0.005290227476507425,
-0.0360519178211689,
0.00516056502237916,
0.014326258562505245,
-0.009848582558333874,
0.004512252751737833,
0.030196940526366234,
-0.006425493862479925,
-0.053801264613866806,
0.049329351633787155,
0.0007772542303428054,
-0.011681144125759602,
-0.00009215937461704016,
-0.008897724561393261,
-0.009376035071909428,
-0.002779098227620125,
-0.0004098773642908782,
0.007560760714113712,
0.0035585134755820036,
0.003760210471227765,
0.014291681349277496,
-0.01251674722880125,
-0.0083790747448802,
0.02013513445854187,
0.0005960870184935629,
-0.005742605309933424,
-0.016815777868032455,
-0.03167220950126648,
0.0005730359116569161,
0.020930398255586624,
0.011986571364104748,
-0.015133046545088291,
0.0009695868939161301,
0.013323535211384296,
0.0005503449938260019,
0.014914060942828655,
-0.02081514336168766,
-0.02157582901418209,
0.0627450942993164,
0.012701155617833138,
0.002004005014896393,
0.023719580844044685,
0.01275878306478262,
-0.0002593248791527003,
-0.019190039485692978,
-0.011508261784911156,
-0.03353935107588768,
0.013012345880270004,
0.0527409166097641,
-0.027845727279782295,
0.013957440853118896,
0.03423088416457176,
-0.04156113043427467,
0.015063893049955368,
-0.009018742479383945,
-0.027499960735440254,
0.03630547970533371,
-0.00323291658423841,
0.001404676353558898,
-0.02064226008951664,
-0.024457216262817383,
-0.026693172752857208,
0.0008665772620588541,
0.05149615556001663,
0.0005672731203958392,
0.009133998304605484,
0.05264871194958687,
0.019328346475958824,
-0.017242223024368286,
0.00905908178538084,
0.029897276312112808,
0.004777340218424797,
0.009128235280513763,
-0.0010445029474794865,
0.019178515300154686,
-0.00767025351524353,
-0.043866243213415146,
0.011150969192385674,
-0.003927330952137709,
-0.029758969321846962,
-0.012943192385137081,
0.0360519178211689,
0.027661319822072983,
0.005561077501624823,
0.026001639664173126,
-0.028675567358732224,
-0.0017000185325741768,
0.01179639995098114,
-0.0013592945178970695,
-0.0186944417655468,
-0.022613128647208214,
-0.011197071522474289,
0.010442147962749004,
0.004028179682791233,
-0.006333289667963982,
-0.0029591848142445087,
-0.0007765339105390012,
0.01726527325809002,
-0.014591345563530922,
0.008286870084702969,
0.00743397930637002,
-0.037434983998537064,
-0.007693304214626551,
-0.013888287357985973,
0.004987681750208139,
-0.02706199139356613,
-0.016446959227323532,
-0.03459969907999039,
0.003299188567325473,
-0.0011957758106291294,
0.012827936559915543,
-0.024872135370969772,
0.006673293188214302,
0.015432710759341717,
-0.002058751415461302,
0.007387877441942692,
0.011588940396904945,
0.001314633060246706,
-0.012205556966364384,
-0.010511301457881927,
-0.015617120079696178,
0.00339139299467206,
0.0429903008043766,
0.016204923391342163,
-0.030704064294695854,
0.009865870699286461,
-0.013069973327219486,
0.0014810331631451845,
-0.03570615127682686,
-0.0313725471496582,
-0.020423274487257004,
-0.03268645703792572,
0.006713632494211197,
-0.023489071056246758,
-0.0163547545671463,
0.0023483308032155037,
0.018763594329357147,
-0.040316373109817505,
0.022278888151049614,
-0.016227973625063896,
-0.0036478363908827305,
0.018406303599476814,
0.058088771998882294,
-0.01879817061126232,
-0.014061170630156994,
-0.008459753356873989,
0.0238348376005888,
-0.010764863342046738,
0.019904624670743942,
0.029689816758036613,
0.0028007086366415024,
0.019143937155604362,
0.04227571561932564,
-0.01251674722880125,
-0.018429353833198547,
0.02200227417051792,
-0.02173718623816967,
-0.011237410828471184,
0.011594703420996666,
-0.013945914804935455,
0.007272621616721153,
-0.007053636480122805,
0.0021523963660001755,
0.020918872207403183,
0.02359279990196228,
-0.013035397045314312,
0.031971875578165054,
0.00694990623742342,
-0.009756377898156643,
0.020284967496991158,
0.00872484128922224,
-0.02114938385784626,
0.022036850452423096,
0.02089582197368145,
-0.00030164525378495455,
0.024826034903526306,
0.0037947872187942266,
0.012182505801320076,
0.023189406841993332,
-0.027776574715971947,
-0.0031291868072003126,
0.041422825306653976,
-0.031810518354177475,
-0.011571652255952358,
0.051864974200725555,
0.004806154407560825,
0.02241719327867031,
0.006990246009081602,
0.039970606565475464,
-0.013519469648599625,
-0.02148362435400486,
-0.004915646743029356,
-0.009168574586510658,
-0.020607681944966316,
-0.023477545008063316,
0.11479447782039642,
-0.005105818621814251,
0.01049401331692934,
0.03547564148902893,
0.011329615488648415,
-0.025471465662121773,
0.027776574715971947,
0.01516762375831604,
0.017910704016685486,
0.017253747209906578,
0.008315684273838997,
0.010557403787970543,
0.044465571641922,
0.028859976679086685,
0.018406303599476814,
0.004146316554397345,
-0.005589891690760851,
0.019570384174585342,
-0.015317455865442753,
-0.002658079843968153,
0.006010574288666248,
0.005137513857334852,
-0.013369637541472912,
0.019397500902414322,
-0.017253747209906578,
0.006800074130296707,
-0.005226837005466223,
-0.0038063128013163805,
0.00926654227077961,
0.022013800218701363,
0.031556956470012665,
-0.02038869820535183,
0.003578683128580451,
-0.02913658879697323,
-0.007485844660550356,
-0.027085041627287865,
-0.01083401683717966,
-0.03902551159262657,
-0.00004146496576140635,
0.0399245023727417,
-0.006857702042907476,
0.01970868930220604,
0.002452060580253601,
0.01778392307460308,
0.03201797604560852,
-0.013876762241125107,
-0.03008168376982212,
-0.008033308200538158,
0.021195486187934875,
-0.02722334861755371,
-0.0010870033875107765,
0.007364826276898384,
0.0017043406842276454,
-0.012286235578358173,
-0.01499474048614502,
-0.02881387434899807,
-0.024480268359184265,
-0.006967194844037294,
-0.00743397930637002,
-0.03632853180170059,
-0.0160205140709877,
0.03434613719582558,
0.041169263422489166,
0.020930398255586624,
-0.004152079112827778
] | 2025-01-06 | 1 | 39757079 | [
"AFP CAR",
"GPC3 CAR",
"HCC cells",
"Huh-7 cell",
"Huh-7 cells",
"AFP",
"effector cells",
"CAR",
"GPC3",
"chimeric antigen receptor T",
"AFP-GPC3 CAR constructs",
"human T lymphocytes",
"specific targeting antigen molecules",
"AFP-GPC3 CAR-T cells",
"AFP CAR-T",
"AFP CAR-T and GPC3 CAR-T cells",
"better anti-tumor effects",
"AFP-GPC3 CAR-T",
"AFP-GPC3",
"HCC",
"significant cell-killing effects",
"single-targeted CAR-T cells",
"GPC3 dual-targeted CAR-T cells",
"CAR-T) cell technology",
"potential benefits",
"partial solid tumors",
"the HCC cells",
"hematologic malignancies",
"GPC3 single-targeted CAR-T cells",
"dual-targeted CAR-T cells"
] | [
"AFP",
"Chimeric antigen receptor T cell",
"GPC3",
"Hepatocellular carcinoma",
"Immunotherapy"
] | 0 | 10.1016/j.ajg.2024.12.002 | [
"Li",
"Chen",
"Huang",
"Cen",
"Zhao",
"Fan",
"He"
] | [
"Embryo Formation Teaching and Research Section, Guangxi University of Chinese Medicine, No.13 Wuhe Avenue, Nanning 530200, Guangxi, China.",
"Embryo Formation Teaching and Research Section, Guangxi University of Chinese Medicine, No.13 Wuhe Avenue, Nanning 530200, Guangxi, China.",
"Embryo Formation Teaching and Research Section, Guangxi University of Chinese Medicine, No.13 Wuhe Avenue, Nanning 530200, Guangxi, China. Electronic address: [email protected].",
"Embryo Formation Teaching and Research Section, Guangxi University of Chinese Medicine, No.13 Wuhe Avenue, Nanning 530200, Guangxi, China. Electronic address: [email protected].",
"Embryo Formation Teaching and Research Section, Guangxi University of Chinese Medicine, No.13 Wuhe Avenue, Nanning 530200, Guangxi, China.",
"Embryo Formation Teaching and Research Section, Guangxi University of Chinese Medicine, No.13 Wuhe Avenue, Nanning 530200, Guangxi, China.",
"Embryo Formation Teaching and Research Section, Guangxi University of Chinese Medicine, No.13 Wuhe Avenue, Nanning 530200, Guangxi, China."
] | [
"39757079"
] | [] | 9.159325 | 5.888499 |
39755643 | 77 | From ex vivo to in vivo chimeric antigen T cells manufacturing: new horizons for CAR T-cell based therapy. | In the past decades, Chimeric Antigen Receptor (CAR)-T cell therapy has achieved remarkable success, leading to the approval of six therapeutic products for haematological malignancies. Recently, the therapeutic potential of this therapy has also been demonstrated in non-tumoral diseases. Currently, the manufacturing process to produce clinical-grade CAR-T cells is complex, time-consuming, and highly expensive. It involves multiple steps, including the collection of T cells from patients or healthy donors, in vitro engineering and expansion, and finally reinfusion into patients. Therefore, despite the impressive clinical outcomes, ex vivo manufacturing process makes CAR-T cells out of reach for many cancer patients. Direct in vivo engineering of T cells could be a more rapid solution able to circumvent both the complexity and the costs associated with ex vivo manufactured CAR-T cells. This novel approach allows to completely eliminate ex vivo cell manipulation and expansion while producing therapeutic cell populations directly in vivo. To date, several studies have demonstrated the feasibility of in vivo T cell reprogramming, by employing injectable viral- or nanocarrier-based delivery platforms in tumour animal models. Additionally, in vivo production of CAR-T cells might reduce the incidence, or at least the severity, of systemic toxicities frequently occurring with ex vivo produced CAR-T cells, such as cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. In this review, we highlight the challenges associated with the current ex vivo manufacturing protocols and review the latest progresses in the emerging field of in vivo CAR-T therapy, by comparing the various platforms so far investigated. Moreover, we offer an overview of the advantages deriving from in vivo reprogramming of other immune cell types, such as Natural Killer and macrophages, with CAR constructs. | [
0.01614723913371563,
0.012987266294658184,
0.028126005083322525,
0.046525564044713974,
-0.021088900044560432,
-0.031442854553461075,
0.013278611935675144,
0.01083019282668829,
-0.0015393664361909032,
-0.007300435099750757,
0.019318418577313423,
-0.010964659042656422,
-0.023576539009809494,
-0.012460604310035706,
0.02282576449215412,
-0.05311444774270058,
0.02926897257566452,
0.007266818080097437,
0.031196333467960358,
0.0025408652145415545,
0.043275948613882065,
0.0026795342564582825,
0.008533048443496227,
0.010113035328686237,
-0.0500217080116272,
-0.020136425271630287,
0.0025366630870848894,
-0.0009195578750222921,
-0.05889652669429779,
-0.03794209286570549,
-0.024966031312942505,
-0.02449539676308632,
-0.02143627405166626,
-0.025638366118073463,
0.0016794361872598529,
0.05817936733365059,
0.056296829134225845,
-0.025548720732331276,
-0.022680092602968216,
0.015878306701779366,
0.07808047533035278,
0.03186866641044617,
0.014152646996080875,
0.078663170337677,
-0.048139169812202454,
0.017335031181573868,
-0.027812248095870018,
-0.0610479973256588,
0.009821690618991852,
0.000850923708640039,
-0.03074811026453972,
0.0034597227349877357,
-0.03370638191699982,
-0.008303334005177021,
-0.07158124446868896,
0.012673510238528252,
-0.022422363981604576,
-0.01105430442839861,
-0.012068409472703934,
0.005978176835924387,
0.025705598294734955,
-0.008925244212150574,
0.042827725410461426,
-0.017010070383548737,
-0.059165459126234055,
0.009031697176396847,
-0.055624496191740036,
0.008874818682670593,
-0.009306233376264572,
0.027520902454853058,
0.0092838229611516,
-0.008073619566857815,
-0.01573263294994831,
0.008420992642641068,
0.025571132078766823,
-0.001994593068957329,
-0.010673314332962036,
0.05208353325724602,
0.02066308818757534,
-0.0018321122042834759,
0.005426301620900631,
-0.020315716043114662,
0.0009608784457668662,
-0.0326978825032711,
-0.005633605178445578,
0.0024988441728055477,
0.02653481252491474,
-0.028193237259984016,
-0.04979759454727173,
-0.0007241605781018734,
-0.04567394033074379,
0.028372526168823242,
-0.04397069290280342,
0.0603308379650116,
0.008936449885368347,
0.029381029307842255,
-0.039085060358047485,
-0.037897270172834396,
0.03218242526054382,
0.05714845657348633,
0.03684394434094429,
0.004179681185632944,
0.005361869931221008,
0.039533283561468124,
0.06149622052907944,
-0.0026977432426065207,
-0.03370638191699982,
0.00147073226980865,
0.021481094881892204,
-0.014791364781558514,
0.07323966920375824,
-0.05925510451197624,
-0.003963973838835955,
0.035252753645181656,
-0.020976845175027847,
-0.037986915558576584,
-0.03285475820302963,
-0.01588951237499714,
-0.004160071257501841,
0.022523215040564537,
-0.007272420916706324,
0.009653606452047825,
0.022220663726329803,
-0.014253497123718262,
0.0039051445201039314,
-0.01484739314764738,
0.07494291663169861,
-0.007866316474974155,
-0.03191348910331726,
-0.05683469772338867,
0.03917470574378967,
0.014275908470153809,
0.02239995263516903,
-0.02655722387135029,
-0.07817012071609497,
0.003885534591972828,
-0.03845755010843277,
0.028731105849146843,
-0.020382948219776154,
0.0065776752308011055,
0.008695529773831367,
-0.016203267499804497,
-0.021100105717778206,
0.001974983373656869,
-0.021974140778183937,
-0.028484582901000977,
0.015934333205223083,
0.04397069290280342,
0.0012088018702343106,
0.026310700923204422,
-0.0334598608314991,
0.03594749793410301,
0.047780591994524,
0.014051796868443489,
0.02404717355966568,
-0.0389954149723053,
-0.026445167139172554,
0.0653957650065422,
-0.014791364781558514,
-0.05405571684241295,
-0.029470674693584442,
-0.003807095577940345,
-0.021962935104966164,
-0.026355523616075516,
-0.00783270038664341,
-0.0025506699457764626,
-0.03626125678420067,
0.023935116827487946,
-0.06530611962080002,
-0.005440308712422848,
-0.009373467415571213,
-0.02530219778418541,
-0.05580378696322441,
-0.016416173428297043,
-0.03263064846396446,
-0.0003398442058824003,
0.01478015910834074,
0.028036359697580338,
-0.03498381748795509,
-0.008998080156743526,
0.006656114012002945,
0.01798495464026928,
0.024607451632618904,
-0.0048688240349292755,
-0.0073676686733961105,
0.003283234778791666,
-0.025705598294734955,
-0.00073956826236099,
-0.05015617236495018,
-0.025122908875346184,
-0.008790777064859867,
-0.014163852669298649,
0.01982267014682293,
0.02610900066792965,
0.02250080369412899,
0.010863808915019035,
0.05038028582930565,
-0.007362065836787224,
-0.007283626589924097,
-0.05226282402873039,
0.05840348079800606,
-0.0452481284737587,
-0.021223368123173714,
0.006521647330373526,
0.0029890884179621935,
-0.006387180183082819,
-0.03807655721902847,
0.03359432518482208,
0.0006583277718164027,
-0.01320017222315073,
0.007765466347336769,
0.0006849410128779709,
-0.01286400482058525,
0.036664657294750214,
-0.0250108540058136,
-0.035252753645181656,
-0.02669169008731842,
0.058493126183748245,
0.027520902454853058,
0.02882074937224388,
-0.0043673743493855,
-0.014724131673574448,
-0.00868992693722248,
0.02640034444630146,
-0.02018124796450138,
0.011233593337237835,
-0.012124436907470226,
-0.026355523616075516,
0.019676998257637024,
-0.036059554666280746,
-0.0002118554839398712,
-0.013950946740806103,
0.011788269504904747,
-0.052979979664087296,
-0.02749849110841751,
-0.014589664526283741,
0.05495215952396393,
0.011642596684396267,
0.03977980837225914,
-0.01485859788954258,
-0.010903028771281242,
0.02404717355966568,
0.033639147877693176,
-0.036306075751781464,
-0.008068016730248928,
-0.01650581881403923,
-0.022803353145718575,
-0.061003174632787704,
0.040272850543260574,
-0.01566540077328682,
0.02324037253856659,
0.011457704938948154,
0.036956001073122025,
-0.009244603104889393,
0.014219880104064941,
0.00475396728143096,
0.0010000979527831078,
-0.008096030913293362,
0.014163852669298649,
-0.001187791465781629,
-0.009821690618991852,
-0.017872899770736694,
-0.02375582791864872,
-0.013144144788384438,
-0.012045998126268387,
0.025055674836039543,
0.006045409943908453,
0.04657038673758507,
0.04800470173358917,
-0.005759667605161667,
0.03296681493520737,
0.0006233103340491652,
0.02942585200071335,
-0.010466011241078377,
-0.06382697820663452,
0.014231085777282715,
0.008079222403466702,
0.040922775864601135,
-0.0037258551456034184,
0.02942585200071335,
0.0018139032181352377,
0.014197468757629395,
-0.01183309219777584,
-0.024383340030908585,
-0.01356995664536953,
-0.019934725016355515,
0.02478674240410328,
0.016875602304935455,
0.009037300013005733,
-0.0558934286236763,
0.02817082591354847,
0.015105120837688446,
-0.015542138367891312,
-0.014006974175572395,
0.04457579553127289,
-0.018713317811489105,
-0.02234392613172531,
0.014589664526283741,
-0.029470674693584442,
0.02691580168902874,
-0.007625396829098463,
-0.019452886655926704,
0.000012037243322993163,
-0.04067625477910042,
-0.007871919311583042,
0.018444383516907692,
-0.02088719978928566,
-0.029649963602423668,
0.052173178642988205,
0.02817082591354847,
0.01573263294994831,
0.007238804362714291,
0.06996763497591019,
0.0029414645396173,
0.02675892412662506,
0.020775144919753075,
-0.009972965344786644,
-0.07400164753198624,
0.023733416572213173,
-0.04468785226345062,
-0.026646867394447327,
0.001266930834390223,
-0.0393315851688385,
0.04074348509311676,
0.019800258800387383,
-0.04325353726744652,
0.009877718053758144,
-0.020932022482156754,
0.05938957259058952,
-0.005084531847387552,
-0.008594679646193981,
-0.02604176662862301,
0.034670062363147736,
-0.028327705338597298,
-0.009832896292209625,
-0.009205383248627186,
-0.041303765028715134,
-0.044082749634981155,
0.051949065178632736,
-0.024988442659378052,
-0.013771656900644302,
0.04181922227144241,
-0.02566077746450901,
0.07462915778160095,
0.01216925960034132,
-0.008230498060584068,
0.02324037253856659,
0.030568821355700493,
-0.004978078417479992,
0.019553735852241516,
0.01834353432059288,
0.019643381237983704,
0.01640496775507927,
-0.014219880104064941,
0.00589973758906126,
0.03632848709821701,
-0.019329624250531197,
0.016158444806933403,
-0.001804098254069686,
-0.029358617961406708,
0.020719116553664207,
0.00571484537795186,
-0.045203305780887604,
0.038054145872592926,
0.04984241724014282,
0.07507738471031189,
-0.018870195373892784,
0.04876668006181717,
-0.017716020345687866,
-0.048632215708494186,
0.010281119495630264,
-0.03464765101671219,
0.0012655301252380013,
0.02236633561551571,
-0.025571132078766823,
0.015205970965325832,
0.03794209286570549,
0.010645300149917603,
0.012707127258181572,
-0.003902343101799488,
0.039891861379146576,
0.010051405057311058,
-0.040407318621873856,
-0.009804882109165192,
-0.03449077159166336,
0.05280068889260292,
0.012001175433397293,
-0.01889260672032833,
-0.1051531583070755,
0.042760491371154785,
-0.007272420916706324,
-0.03617161139845848,
0.0014595267130061984,
0.005202190019190311,
-0.02047259360551834,
0.0235317163169384,
-0.0386144258081913,
0.06207890808582306,
0.03991427272558212,
0.013413078151643276,
0.03977980837225914,
-0.026826156303286552,
-0.03523034229874611,
-0.03574579954147339,
0.029672374948859215,
-0.025795243680477142,
0.046660032123327255,
-0.003596991067752242,
-0.013166556134819984,
-0.01740226522088051,
0.030904987826943398,
-0.025615954771637917,
0.024293696507811546,
0.007513341028243303,
0.0218844972550869,
-0.016393762081861496,
-0.007608588319271803,
0.04235709086060524,
0.015183559618890285,
0.030927399173378944,
0.010028993710875511,
-0.0305239986628294,
0.02043897658586502,
-0.013749245554208755,
-0.030680876225233078,
0.00907091610133648,
0.013446695171296597,
0.027520902454853058,
-0.025795243680477142,
-0.03388567268848419,
-0.027745014056563377,
0.03168937936425209,
-0.0008390177390538156,
-0.026221055537462234,
-0.03554409742355347,
0.032473769038915634,
-0.027117501944303513,
-0.0035997924860566854,
-0.0020548230968415737,
0.0275881364941597,
-0.013301022350788116,
0.0005347162368707359,
0.005062120500952005,
-0.031353212893009186,
0.02117854543030262,
0.040788307785987854,
-0.03446836397051811,
0.015755044296383858,
-0.029537906870245934,
-0.01345790084451437,
-0.017368648201227188,
-0.008146456442773342,
0.005731653887778521,
-0.009972965344786644,
-0.011519335210323334,
-0.014533636160194874,
0.032092779874801636,
-0.036575011909008026,
-0.012908827513456345,
0.042110566049814224,
0.014141441322863102,
-0.02136904001235962,
0.025795243680477142,
0.0020604259334504604,
0.007266818080097437,
0.060779061168432236,
0.05396607145667076,
-0.0125054270029068,
0.001364279305562377,
-0.029022451490163803,
0.00714915944263339,
-0.03951087221503258,
-0.025996943935751915,
-0.005291834939271212,
-0.0522180013358593,
0.037404224276542664,
-0.009580770507454872,
0.012583865784108639,
0.010152255184948444,
0.030546410009264946,
-0.010673314332962036,
-0.005532755050808191,
-0.014152646996080875,
0.01297606062144041,
0.036731887608766556,
0.031510088592767715,
-0.04365693777799606,
-0.007216393016278744,
-0.039824627339839935,
0.028506994247436523,
0.02324037253856659,
0.012684715911746025,
0.015318026766180992,
-0.008348156698048115,
0.006622497458010912,
0.008807585574686527,
-0.04587564244866371,
-0.0022691297344863415,
-0.031285978853702545,
0.051590487360954285,
-0.0000418458366766572,
0.0647682473063469,
-0.00454386230558157,
0.03897300362586975,
0.04934937134385109,
0.026288289576768875,
0.013805273920297623,
0.06925047934055328,
0.01776084303855896,
0.03229447826743126,
-0.06382697820663452,
0.0036334090400487185,
0.024069584906101227,
-0.00905971135944128,
-0.031577322632074356,
-0.002919053426012397,
-0.043500058352947235,
-0.01872452348470688,
-0.020102810114622116,
-0.003997590392827988,
-0.0026052971370518208,
-0.008706735447049141,
-0.016337735578417778,
0.004894036799669266,
-0.0013747845077887177,
-0.019676998257637024,
-0.04657038673758507,
-0.014376758597791195,
-0.0207639392465353,
-0.006807389669120312,
0.0305239986628294,
0.003933158237487078,
-0.010757355950772762,
0.01647220179438591,
-0.032406534999608994,
-0.032316889613866806,
-0.015867101028561592,
0.036956001073122025,
-0.022377541288733482,
-0.028282882645726204,
0.01179947517812252,
0.005258217919617891,
0.011597774922847748,
-0.006902636960148811,
-0.0037650747690349817,
0.015743838623166084,
-0.0034149002749472857,
-0.01814183220267296,
0.016304118558764458,
-0.018814167007803917,
0.03103945404291153,
-0.020293304696679115,
0.022635269910097122,
-0.030389530584216118,
0.024271285161376,
-0.02155953459441662,
-0.024607451632618904,
-0.018029777333140373,
-0.00876836571842432,
-0.018769346177577972,
-0.004863221663981676,
-0.017839282751083374,
0.018903812393546104,
-0.029134506359696388,
-0.027408847585320473,
0.03410978242754936,
-0.002919053426012397,
-0.04840810224413872,
-0.018993457779288292,
0.045113664120435715,
-0.01904948428273201,
-0.011171963065862656,
0.0028938408941030502,
-0.00805681198835373,
0.048139169812202454,
0.023150727152824402,
-0.0029330605175346136,
0.005585981532931328,
-0.014152646996080875,
0.03451318293809891,
-0.03222724795341492,
-0.027901893481612206,
-0.019934725016355515,
0.033571917563676834,
-0.003938761074095964,
0.02462986297905445,
-0.05271104723215103,
-0.010135446675121784,
0.0010701328283175826,
-0.004955667536705732,
0.017928926274180412,
0.024024762213230133,
0.009687223471701145,
0.019587352871894836,
-0.02868628315627575,
0.035700976848602295,
-0.004356169141829014,
0.004913646727800369,
-0.013760451227426529,
-0.006151862908154726,
-0.031891077756881714,
-0.0006625298992730677,
-0.00106803176458925,
-0.034826941788196564,
-0.03646295517683029,
0.04107965528964996,
0.01988990418612957,
-0.00726121524348855,
0.010437997058033943,
-0.004843611735850573,
0.053876426070928574,
0.008264115080237389,
-0.04737719148397446,
-0.02098805084824562,
0.041057243943214417,
0.020573444664478302,
0.011244799010455608,
0.00452145142480731,
0.009552756324410439,
-0.03897300362586975,
-0.009575167670845985,
-0.006936253514140844,
-0.012303725816309452,
-0.011199976317584515,
-0.0004583782283589244,
-0.03339262679219246,
0.011698625050485134,
-0.017648788169026375,
0.0065384553745388985,
0.01834353432059288,
0.0028938408941030502,
-0.0330788716673851,
-0.02153712324798107,
0.03153249993920326,
0.009255808778107166,
-0.007961563766002655,
0.0014497218653559685,
-0.012527837418019772,
0.009860909543931484,
0.004238510504364967,
-0.01846679486334324,
0.008908435702323914,
0.011110331863164902,
-0.029582729563117027,
0.014578458853065968,
0.01808580569922924,
-0.028865572065114975,
0.010141049511730671,
0.019553735852241516,
0.002821004716679454,
-0.016158444806933403,
-0.035476863384246826,
0.030030952766537666,
-0.040990009903907776,
0.004230106249451637,
0.009126944467425346,
-0.0069194454699754715,
-0.00886361300945282,
0.0647234246134758,
0.0713123083114624,
-0.013637189753353596,
0.002798593370243907,
0.0034905378706753254,
-0.013110527768731117,
-0.024988442659378052,
0.008062414824962616,
0.018870195373892784,
0.009950554929673672,
-0.01221408136188984,
0.012639893218874931,
0.045629117637872696,
0.02179485186934471,
-0.018802961334586143,
-0.02994130738079548,
-0.010992673225700855,
-0.009625592269003391,
0.027632959187030792,
-0.04943901672959328,
0.0024302101228386164,
0.0024218058679252863,
-0.02169400081038475,
0.0117658581584692,
-0.04341041296720505,
-0.008874818682670593,
0.011166360229253769,
-0.01092544011771679,
0.004232907667756081,
0.01698765903711319,
-0.00926701445132494,
-0.005490733776241541,
0.00006683952960884199,
-0.01869090646505356,
-0.030837753787636757,
-0.0018531227251514792,
0.02104407735168934,
-0.008224895223975182,
0.009676017798483372,
-0.008292128331959248,
-0.024607451632618904,
-0.05656576529145241,
0.024091996252536774,
0.02024848200380802,
0.012191670015454292,
-0.03339262679219246,
0.02552630938589573,
-0.01866849511861801,
-0.016898013651371002,
-0.005286232102662325,
-0.007715041283518076,
0.022668886929750443,
0.004824001807719469,
-0.011323237791657448,
-0.03590267524123192,
-0.03774039074778557,
-0.004826803226023912,
-0.012068409472703934,
-0.000636266777291894,
0.045629117637872696,
0.010068212635815144,
0.026781335473060608,
0.005028503946959972,
0.04184163361787796,
-0.02330760471522808,
0.001715854392386973,
0.028798339888453484,
0.022512009367346764,
-0.01834353432059288,
0.08045606315135956,
-0.011171963065862656,
0.004773576743900776,
-0.00902609433978796,
-0.02713991329073906,
-0.032249659299850464,
-0.022321514785289764,
-0.002483436604961753,
0.043881047517061234,
-0.039734985679388046,
-0.045561887323856354,
0.021256983280181885,
-0.009771265089511871,
0.02279214933514595,
-0.01791772060096264,
-0.03803173825144768,
0.03319092467427254,
-0.011844297870993614,
0.01850041188299656,
0.02317313849925995,
-0.014029385522007942,
0.006409591529518366,
-0.0301654189825058,
-0.01495944894850254,
0.006807389669120312,
-0.028327705338597298,
-0.021167339757084846,
0.011104729026556015,
-0.033280570060014725,
0.020584648475050926,
-0.01481377612799406,
-0.03458041697740555,
-0.02337483875453472,
-0.027005447074770927,
0.018040983006358147,
0.020461387932300568,
-0.01036516111344099,
0.025122908875346184,
-0.019733024761080742,
0.00794475618749857,
0.018511617556214333,
-0.003482133848592639,
0.01068452000617981,
-0.03818861395120621,
0.001360077178105712,
0.010320338420569897,
-0.024136818945407867,
-0.01154174655675888,
-0.009698429144918919,
-0.009244603104889393,
0.023330016061663628,
0.022030169144272804,
0.00015162549971137196,
-0.00004464722951524891,
0.02047259360551834,
-0.018231477588415146,
0.01183309219777584,
0.01753673143684864,
-0.021032871678471565,
-0.005961368326097727,
0.027184735983610153,
-0.02604176662862301,
-0.011575363576412201,
-0.008432198315858841,
0.023397250100970268,
-0.024585040286183357,
0.03229447826743126,
-0.018702112138271332,
0.001409802003763616,
0.032899580895900726,
-0.059748150408267975,
-0.0035857853945344687,
-0.007378873880952597,
-0.018623672425746918,
0.0025968931149691343,
0.020192453637719154,
-0.047108255326747894,
-0.007978372275829315,
0.006594483274966478,
-0.02640034444630146,
0.006762566976249218,
-0.026198644191026688,
0.03426666185259819,
0.009451906196773052,
0.004510245751589537,
0.0021808859892189503,
-0.014264702796936035,
-0.05800008028745651,
0.007250010035932064,
0.03653018921613693,
-0.02713991329073906,
-0.009261411614716053,
-0.03155491128563881,
0.021256983280181885,
0.0008978470577858388,
-0.0024358127266168594,
-0.011261607520282269,
-0.01631532423198223,
-0.06853332370519638,
-0.0145224304869771,
-0.00040725278086028993,
0.021548328921198845,
-0.04751165583729744,
-0.0028448165394365788,
-0.01323378924280405,
-0.036956001073122025,
0.008426595479249954,
-0.011233593337237835,
-0.006263918709009886,
0.017222976312041283,
-0.010527641512453556,
0.007053912151604891,
0.026669278740882874,
0.02169400081038475,
-0.010247502475976944,
-0.0054879323579370975,
0.005933354143053293,
-0.007395682390779257,
0.018130628392100334,
-0.02301626093685627,
0.018522823229432106,
-0.0375162810087204,
-0.030703287571668625,
-0.0055831801146268845,
0.010118638165295124,
-0.003454119898378849,
-0.014724131673574448,
0.01698765903711319,
-0.003737060818821192,
0.003395290579646826,
0.008628295734524727,
0.041370999068021774,
0.04509125277400017,
-0.027700191363692284,
-0.002298544393852353,
-0.010914234444499016,
-0.01982267014682293,
0.05069404095411301,
-0.051366377621889114,
-0.006432002410292625,
-0.021223368123173714,
0.02891039475798607,
-0.011844297870993614,
0.016035184264183044,
-0.012920033186674118,
0.02698303572833538,
-0.02346448414027691,
-0.002067429479211569,
0.005661618895828724,
0.010034596547484398,
-0.023038670420646667,
-0.03910747170448303,
-0.01734623685479164,
-0.01047721691429615,
-0.033639147877693176,
0.00755816325545311,
-0.008555459789931774,
0.0011366659309715033,
0.01497065369039774,
0.00001881092794064898,
-0.001752272481098771,
-0.022870587185025215,
-0.02239995263516903,
-0.02172761783003807,
-0.016483407467603683,
-0.017772048711776733,
-0.023912707343697548,
-0.005204991437494755,
0.0014413176104426384,
-0.00039324580575339496,
0.038211025297641754,
-0.007182776462286711,
0.012617482803761959,
-0.04038490727543831,
-0.03529757633805275,
-0.013581162318587303,
0.06212373077869415,
-0.02433851920068264,
0.006633703131228685,
-0.004218900576233864,
0.034602828323841095,
0.001225610263645649,
0.013446695171296597,
0.0064712222665548325,
0.008891627192497253,
0.01860126107931137,
0.009676017798483372,
0.011788269504904747,
0.0018629275728017092,
0.017749637365341187,
0.06360287219285965,
0.03912988305091858,
-0.0211449284106493,
-0.02707267925143242,
-0.004129256121814251,
-0.01805218867957592,
0.004815597552806139,
0.047108255326747894,
-0.013883712701499462,
-0.0037958899047225714,
0.0017438683426007628,
-0.000025518957045278512,
0.021581945940852165,
0.008348156698048115,
-0.04090036451816559,
0.028327705338597298,
0.041370999068021774,
0.021066488698124886,
0.00425531854853034,
-0.0010799376759678125,
-0.010421188548207283,
-0.009911335073411465,
-0.010482819750905037,
-0.024809151887893677,
0.05616236478090286,
0.015060299076139927,
-0.03469247370958328,
0.036799121648073196,
-0.008762762881815434,
-0.000499348621815443,
-0.038211025297641754,
0.05580378696322441,
0.02004678174853325,
0.04358970373868942,
0.0006072023534215987,
-0.0019805862102657557,
0.011250401847064495,
-0.014163852669298649,
-0.0356561541557312,
0.006202287971973419,
-0.025167731568217278,
0.041953690350055695,
-0.023128315806388855,
-0.017357442528009415,
0.012079614214599133,
0.0002148319617845118,
-0.02191811241209507,
0.003103945404291153,
0.03991427272558212,
0.0037930887192487717,
0.003770677372813225,
-0.01966579258441925,
0.033639147877693176,
-0.020943228155374527,
0.011777063831686974,
0.01331222802400589,
0.018321122974157333,
0.01643858477473259,
0.016673902049660683,
0.03758351504802704,
-0.0356561541557312,
0.009143752977252007,
0.007989577949047089,
0.015911921858787537,
0.009261411614716053,
-0.03778521344065666,
0.007053912151604891,
-0.011312032118439674,
0.017906516790390015,
0.017615171149373055,
-0.021738823503255844,
-0.03404254838824272,
0.0024722309317439795,
0.05741738900542259,
-0.014018179848790169,
-0.02246718667447567,
-0.034894175827503204,
-0.001137366285547614,
-0.01995713636279106,
-0.006207890808582306,
-0.06732311844825745,
0.021413862705230713,
0.03410978242754936,
-0.014107824303209782,
-0.01441037468612194,
0.014724131673574448,
-0.01047721691429615,
-0.012908827513456345,
-0.001350272330455482,
0.044979196041822433,
0.0019245583098381758,
0.04583081975579262,
-0.018130628392100334,
0.057327743619680405,
-0.002511450555175543,
0.012415781617164612,
0.01592312753200531,
-0.011328840628266335,
-0.017357442528009415,
-0.019766641780734062,
-0.06956423819065094,
-0.04148305580019951,
-0.030501587316393852,
-0.016942836344242096,
-0.029649963602423668,
0.01772722601890564,
0.037830036133527756,
0.04385863617062569,
0.008090428076684475,
0.007014692761003971,
-0.024540219455957413,
0.019867492839694023,
0.010415585711598396,
0.013435489498078823,
0.009737648069858551,
-0.0017368647968396544,
-0.00746291596442461,
-0.02253442071378231,
0.00110444996971637,
-0.020394153892993927,
0.06284088641405106,
0.032316889613866806,
0.005053716246038675,
-0.02985166385769844,
-0.0150827094912529,
0.025122908875346184,
0.03868165984749794,
0.0062527135014534,
0.0026375132147222757,
-0.0013348646461963654,
-0.024024762213230133,
-0.007289229426532984,
0.010197076946496964,
0.023061081767082214,
0.06732311844825745,
0.01992351934313774,
0.029739607125520706,
0.03919711709022522,
0.015161149203777313,
-0.003636210458353162,
0.000027466801839182153,
-0.0013551748124882579,
0.013144144788384438,
-0.00425531854853034,
0.02868628315627575,
-0.013401873409748077,
0.0013859900645911694,
-0.0038911374285817146,
0.014656897634267807,
0.02985166385769844,
0.021873291581869125,
0.02011401578783989,
-0.0011989970225840807,
0.006415194366127253,
0.001993192359805107,
-0.010617286898195744,
0.0003767876187339425,
0.004078831057995558,
-0.040990009903907776,
0.004913646727800369,
-0.008129647932946682,
0.007608588319271803,
-0.03222724795341492,
0.013301022350788116,
0.01224769838154316,
-0.010432394221425056,
-0.0063423579558730125,
-0.011945147998631,
-0.010981467552483082,
-0.00755816325545311,
-0.014096618629992008,
0.0064712222665548325,
-0.024652274325489998,
-0.01514994353055954,
-0.025391843169927597,
-0.00841538980603218,
0.019161541014909744,
0.021906908601522446,
-0.013805273920297623,
0.016640285030007362,
0.013805273920297623,
0.018870195373892784,
-0.011440896429121494,
-0.026445167139172554,
0.02581765502691269,
-0.017010070383548737,
-0.018186654895544052,
-0.06606809794902802,
0.047825414687395096,
-0.00048814306501299143,
-0.035633742809295654,
-0.0012060004519298673,
0.0058829290792346,
-0.012796771712601185,
0.0342218391597271,
0.031510088592767715,
-0.015138737857341766,
0.013950946740806103,
0.026310700923204422,
0.040048740804195404,
-0.005120949819684029,
0.00753575237467885,
0.014757747761905193,
-0.004286134149879217,
-0.03294440358877182,
-0.034961406141519547,
-0.008773968555033207,
0.0070258984342217445,
0.005905340425670147,
-0.02366618439555168,
0.0294034406542778,
-0.012202875688672066,
0.025772832334041595,
-0.02397993952035904,
0.01631532423198223,
-0.015284410677850246,
0.017626376822590828,
-0.014533636160194874,
-0.018713317811489105,
0.03287716954946518,
-0.007031501270830631,
0.008040003478527069,
0.023890295997262,
0.013805273920297623,
0.01286400482058525,
-0.0019777847919613123,
-0.023128315806388855,
-0.0031095482409000397,
-0.02337483875453472,
0.001008502091281116,
0.05625201016664505,
0.0010134045733138919,
-0.045046430081129074,
0.04471026360988617,
0.019251184538006783,
-0.0178280770778656,
0.02162676863372326,
0.007126748561859131,
-0.008460212498903275,
0.0028322101570665836,
-0.020898405462503433,
0.0063423579558730125,
0.03910747170448303,
-0.012292520143091679,
0.010516435839235783,
0.0023979940451681614,
-0.008712338283658028,
-0.0014525232836604118,
-0.01179947517812252,
0.01066771149635315,
0.02037174254655838,
0.00296947848983109,
-0.023845473304390907,
0.0047287545166909695,
0.01018587127327919,
0.02368859574198723,
0.028350116685032845,
0.01702127419412136,
0.002711750101298094,
0.02536943182349205,
-0.010785370133817196,
-0.000335467018885538,
0.0077430554665625095,
-0.0024358127266168594,
0.0017690808745101094,
-0.012012381106615067,
-0.042693257331848145,
-0.04316389188170433,
-0.0006625298992730677,
-0.01814183220267296,
0.005700838286429644,
-0.02182846888899803,
0.02346448414027691,
-0.014455197378993034,
-0.014937037602066994,
0.021189751103520393,
0.007552560418844223,
-0.006723347585648298,
-0.030546410009264946,
-0.01455604750663042,
-0.031353212893009186,
-0.003311248729005456,
0.008381773717701435,
-0.012258904054760933,
0.01676354743540287,
0.0360371433198452,
-0.000049637215852271765,
0.013323433697223663,
0.032541003078222275,
0.01717815361917019,
-0.01662907935678959,
-0.012460604310035706,
-0.05638647451996803,
0.01985628716647625,
-0.036149200052022934,
-0.0042889355681836605,
0.006095835007727146,
-0.02382306195795536,
-0.0375162810087204,
-0.0076702190563082695,
0.022220663726329803,
-0.009367864578962326,
0.007177173625677824,
0.0009251606534235179,
-0.009905732236802578,
-0.00004876177990809083,
0.0011968959588557482,
-0.010751753114163876,
-0.01978905312716961,
-0.0013117531780153513,
-0.018063394352793694,
-0.004661520943045616,
0.004358970560133457,
-0.048139169812202454,
-0.05638647451996803,
0.02891039475798607,
0.00433655921369791,
0.014948243275284767,
-0.014735337346792221,
0.006454413756728172,
-0.00878517422825098,
-0.02655722387135029,
0.08332468569278717,
0.01676354743540287,
0.013334639370441437,
-0.022007757797837257,
-0.0008236101130023599,
-0.03162214532494545,
0.02231030911207199,
0.05015617236495018,
0.013188966549932957,
0.03130839020013809,
-0.011340046301484108,
-0.016718724742531776,
-0.02830529399216175,
-0.015407671220600605,
-0.040564198046922684,
-0.00746291596442461,
0.0006464218604378402,
0.0032131997868418694,
-0.020416565239429474,
-0.00016335633699782193,
-0.0035717785358428955,
0.03912988305091858,
-0.014623281545937061,
-0.008908435702323914,
-0.00602860189974308,
-0.009110135957598686,
-0.0006852911901660264,
-0.004877228289842606,
-0.003403694834560156,
0.009457509033381939,
0.018074600026011467,
0.01044359989464283,
0.014500020071864128,
-0.01992351934313774,
0.019508913159370422,
-0.011721036396920681,
0.01342428382486105,
-0.04208815470337868,
-0.012550248764455318,
0.015575755387544632,
-0.022780943661928177,
-0.006975473370403051,
0.014623281545937061,
0.033504683524370193,
-0.048139169812202454,
-0.040698666125535965,
0.030860165134072304,
-0.01058927271515131,
0.0021164538338780403,
-0.019945930689573288,
-0.012068409472703934,
0.0013649796601384878,
0.009300630539655685,
-0.006745758932083845,
0.015934333205223083,
0.006291932892054319,
0.0032412137370556593,
-0.019508913159370422,
0.018253888934850693,
0.0019679798278957605,
0.01393974106758833,
-0.026960624381899834,
-0.0002614051627460867,
0.001974983373656869,
-0.05575896427035332,
-0.05656576529145241,
0.01308811642229557,
-0.013244994916021824,
-0.03023265302181244,
-0.005462720058858395,
-0.012012381106615067,
0.011183167807757854,
0.03177902474999428,
-0.07211910933256149,
-0.006398385856300592,
0.039891861379146576,
0.005294636357575655,
-0.020024370402097702,
-0.01895984075963497,
0.010762958787381649,
0.01702127419412136,
0.0014469204470515251,
0.007905536331236362,
0.009900129400193691,
0.006258315872400999,
0.03780762478709221,
-0.018556440249085426,
0.020001959055662155,
0.0327427014708519,
0.016080006957054138,
0.012180464342236519,
0.01198996976017952,
-0.030904987826943398,
0.05432464927434921,
-0.02033812738955021,
0.0009412686922587454,
-0.023643773049116135,
-0.012875210493803024,
-0.000684240716509521,
0.00023601751308888197,
0.009210986085236073,
-0.00144271831959486,
0.013144144788384438,
0.006370371673256159,
0.003204795764759183,
-0.022780943661928177,
-0.00740688806399703,
0.027924302965402603,
0.020976845175027847,
-0.005457117222249508,
-0.021671591326594353,
-0.006415194366127253,
-0.041796810925006866,
-0.00015705320402048528,
-0.010040199384093285,
0.00595576548948884,
-0.0071883792988955975,
0.023800650611519814,
-0.0026066978462040424,
-0.021525917574763298,
-0.008174470625817776,
0.01018587127327919,
0.015844689682126045,
-0.003092739963904023,
0.0015477706911042333,
-0.010068212635815144,
-0.0090092858299613,
-0.005034106317907572,
-0.006499235983937979,
-0.008146456442773342,
-0.011519335210323334,
-0.00017578752886038274,
-0.010286722332239151,
0.02404717355966568,
0.00456067081540823,
0.018702112138271332,
-0.020427770912647247,
-0.031801436096429825,
-0.0020057987421751022,
0.02839493751525879,
-0.00727802375331521,
0.038502369076013565,
-0.024271285161376,
-0.009384673088788986,
-0.029358617961406708,
0.005849312525242567,
-0.011889119632542133,
0.0180185716599226,
-0.034535594284534454,
0.0002095793461194262,
0.017032479867339134,
0.0015967950457707047,
0.023419661447405815,
0.030837753787636757,
-0.011754652485251427,
0.005493535194545984,
-0.0204053595662117,
0.0057876817882061005,
0.013883712701499462,
0.03612678870558739,
-0.007888727821409702,
0.00021098005527164787,
-0.020382948219776154,
-0.02433851920068264,
-0.0048996396362781525,
-0.03036711923778057,
-0.04881150275468826,
0.026602044701576233,
-0.007787877693772316,
0.006751361768692732,
-0.008645104244351387,
-0.002755171852186322,
-0.0043953885324299335,
0.00753575237467885,
-0.0529351569712162,
0.012034792453050613,
-0.015530932694673538,
0.034961406141519547,
0.016640285030007362,
0.04002632945775986,
-0.010639697313308716,
0.00934545323252678,
0.0034877366852015257,
0.017155742272734642,
-0.0011345648672431707,
0.005838106852024794,
0.03404254838824272,
-0.02749849110841751,
-0.03139803186058998,
0.025167731568217278,
0.02440575137734413,
-0.017615171149373055,
0.002002997323870659,
-0.01058927271515131,
-0.029067272320389748,
0.014544841833412647,
-0.03664224594831467,
0.018578849732875824,
0.005810093134641647,
0.008174470625817776,
0.023733416572213173,
0.027543313801288605,
-0.03162214532494545,
0.011452102102339268,
-0.006387180183082819,
-0.004706343170255423,
-0.006202287971973419,
-0.006897034123539925,
-0.0156317837536335,
0.009967362508177757,
0.0007941954536363482,
0.029829252511262894,
0.028551816940307617,
0.007165967952460051,
-0.018365943804383278,
-0.0020001959055662155,
-0.021346628665924072,
-0.021380245685577393,
0.015172354876995087,
-0.03229447826743126,
-0.007490929681807756,
0.029224151745438576,
0.005084531847387552,
-0.003381283488124609,
0.023643773049116135,
0.01757034845650196,
0.0020744327921420336,
-0.009222191758453846,
-0.015486110933125019,
0.02008039876818657,
-0.033280570060014725,
-0.001627610414288938,
0.10551173239946365,
-0.03500622883439064,
0.006387180183082819,
0.012001175433397293,
0.006185479927808046,
-0.03227206692099571,
0.03904023766517639,
-0.004160071257501841,
0.02130180597305298,
-0.028103593736886978,
0.03186866641044617,
-0.02136904001235962,
0.023285193368792534,
0.009205383248627186,
0.046525564044713974,
-0.00230414723046124,
0.023217961192131042,
0.04787023365497589,
0.007255612872540951,
-0.004294538404792547,
-0.010068212635815144,
0.018746934831142426,
0.008292128331959248,
0.018937429413199425,
-0.037180110812187195,
-0.018231477588415146,
-0.010880617424845695,
0.012236492708325386,
-0.020461387932300568,
-0.00744610745459795,
0.021492300555109978,
0.007877522148191929,
-0.001770481583662331,
-0.014063002541661263,
-0.016640285030007362,
-0.02008039876818657,
-0.01042679138481617,
0.012830388732254505,
0.03292199224233627,
-0.019878698512911797,
0.009636797942221165,
0.0030086981132626534,
0.017648788169026375,
-0.016841985285282135,
0.019071895629167557,
0.01010743249207735,
-0.015710221603512764,
0.0025548720732331276,
0.015687810257077217,
-0.028103593736886978,
0.0030507189221680164,
-0.01692042499780655,
0.020326921716332436,
-0.003616600763052702,
-0.04385863617062569,
0.009872115217149258,
-0.014679308980703354,
-0.01688680797815323,
-0.004527054261416197,
-0.019296007230877876,
-0.01308811642229557,
0.02420405112206936,
0.0305239986628294,
-0.011698625050485134,
0.009115738794207573
] | 2025-01-05 | 137 | 39755643 | [
"vivo T cell reprogramming",
"T cells",
"ex vivo cell manipulation",
"CAR)-T cell therapy",
"therapeutic cell populations",
"other immune cell types",
"ex vivo manufacturing process",
"ex vivo",
"vivo reprogramming",
"vivo engineering",
"produced CAR-T cells",
"manufactured CAR-T cells",
"CAR-T cells",
"vivo production",
"vivo CAR-T therapy",
"clinical-grade CAR-T cells",
"cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome",
"vivo",
"the current ex vivo manufacturing protocols",
"Chimeric Antigen Receptor",
"non-tumoral diseases",
"many cancer patients",
"tumour animal models",
"CAR constructs",
"remarkable success",
"Natural Killer",
"systemic toxicities",
"healthy donors",
"patients",
"multiple steps"
] | [
"CAR T cell",
"Manufacturing",
"T cell engineering"
] | 0 | 10.1186/s12967-024-06052-3 | [
"Pinto",
"Lione",
"Compagnone",
"Paccagnella",
"Salvatori",
"Greco",
"Frezza",
"Marra",
"Aurisicchio",
"Roscilli",
"Conforti"
] | [
"Evvivax Biotech, Via Castel Romano 100, 00128, Rome, Italy.\nDepartment of Clinical Sciences and Translational Medicine, University of Rome \"Tor Vergata\", Via Montpellier 1, 00133, Rome, Italy.",
"Takis Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Evvivax Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Takis Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Takis Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Takis Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Takis Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Takis Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Evvivax Biotech, Via Castel Romano 100, 00128, Rome, Italy.\nTakis Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Takis Biotech, Via Castel Romano 100, 00128, Rome, Italy.",
"Evvivax Biotech, Via Castel Romano 100, 00128, Rome, Italy. [email protected].\nTakis Biotech, Via Castel Romano 100, 00128, Rome, Italy. [email protected]."
] | [
"39755643",
"31707680",
"30936321",
"20555360",
"28180032",
"18453625",
"18354214",
"32397414",
"33833759",
"33795428",
"36123710",
"32739874",
"26700307",
"3122749",
"2784887",
"2513569",
"36094837",
"11123291",
"28187291",
"32616000",
"33888899",
"21217771",
"12974476",
"10933398",
"30131370",
"29872565",
"21832238",
"25154820",
"26885860",
"29321369",
"27479233",
"37608202",
"19773745",
"30309819",
"30097433",
"30755478",
"25985798",
"29400710",
"33028589",
"23839099",
"38727261",
"27194949",
"25849134",
"35647274",
"31488817",
"12427307",
"19377047",
"22354001",
"25949885",
"29241547",
"34325726",
"23732988",
"28405515",
"23939024",
"35805001",
"37433102",
"29385370",
"33824268",
"27347557",
"28765140",
"33892148",
"30482221",
"31900462",
"38247837",
"34607523",
"37010679",
"29907163",
"29025771",
"28924019",
"20428207",
"24782509",
"25359408",
"30592986",
"30387077",
"32067497",
"29434334",
"37511562",
"35598048",
"20842061",
"37249512",
"28416815",
"33247092",
"31741773",
"34162832",
"28669112",
"26232436",
"30997367",
"30224381",
"36918221",
"27769802",
"28817344",
"36423871",
"19905893",
"22885409",
"25365242",
"31027272",
"28858523",
"28855514",
"32158206",
"34224787",
"37153571",
"25046195",
"33523869",
"31951421",
"34669421",
"26264835",
"36002054",
"31511695",
"34990237",
"30275568",
"34220853",
"28925994",
"14965378",
"21653320",
"33408186",
"31270272",
"23302231",
"25006133",
"28725044",
"26772158",
"35361234",
"32192067",
"33140856",
"32361713",
"36441083",
"36750830",
"36638788",
"24686242",
"37561596",
"37224732",
"26999600",
"22647574",
"33335528",
"28955341",
"29046484",
"35158451",
"18855921"
] | [] | 8.724868 | 3.100957 |
39755633 | 78 | Current status and innovative developments of CAR-T-cell therapy for the treatment of breast cancer. | Breast cancer will overtake all other cancers in terms of diagnoses in 2024. Breast cancer counts highest among women in terms of cancer incidence and death rates. Innovative treatment approaches are desperately needed because treatment resistance brought on by current clinical drugs impedes therapeutic efficacy. The T cell-based immunotherapy known as chimeric antigen receptor (CAR) T cell treatment, which uses the patient's immune cells to fight cancer, has demonstrated remarkable efficacy in treating hematologic malignancies; nevertheless, the treatment effects in solid tumors, like breast cancer, have not lived up to expectations. We discuss in detail the role of tumor-associated antigens in breast cancer, current clinical trials, barriers to the intended therapeutic effects of CAR-T cell therapy, and potential ways to increase treatment efficacy. Finally, our review aims to stimulate readers' curiosity by summarizing the most recent advancements in CAR-T cell therapy for breast cancer. | [
0.0020095580257475376,
-0.002213285770267248,
0.0634632259607315,
0.06909553706645966,
-0.03441471979022026,
-0.030334625393152237,
0.008492807857692242,
0.016287121921777725,
0.0009063799516297877,
-0.002385137602686882,
0.012794648297131062,
-0.024946236982941628,
-0.024502748623490334,
-0.005396702792495489,
0.004867288284003735,
-0.023748818784952164,
0.006652330048382282,
-0.015511016361415386,
0.03119942732155323,
0.02873806655406952,
-0.0034758425317704678,
-0.031886834651231766,
-0.010333285667002201,
-0.01994590274989605,
-0.016187336295843124,
-0.0023657348938286304,
-0.0053773000836372375,
0.0015272641321644187,
-0.05756482854485512,
-0.011663751676678658,
0.02915938012301922,
-0.011685926467180252,
-0.02089940384030342,
-0.04226446896791458,
0.014745998196303844,
0.02103245072066784,
0.0035950299352407455,
0.002358805388212204,
0.00719560356810689,
-0.0038029153365641832,
0.021110061556100845,
0.02893763594329357,
-0.00008350059943040833,
0.07175646722316742,
-0.03822872415184975,
0.01378141064196825,
0.020544612780213356,
-0.06882943958044052,
-0.040024854242801666,
0.03474733605980873,
-0.02915938012301922,
-0.017650848254561424,
-0.02747412398457527,
0.061334483325481415,
-0.048384614288806915,
0.04397190362215042,
-0.04097835347056389,
0.028582844883203506,
0.021010275930166245,
0.016375819221138954,
0.011214720085263252,
-0.00130551983602345,
0.0043184710666537285,
-0.03252989426255226,
-0.07024860382080078,
0.014867957681417465,
-0.03217510133981705,
-0.0114863570779562,
0.006059164181351662,
-0.016908004879951477,
0.018504565581679344,
-0.04401624947786331,
-0.004739785101264715,
0.04882810264825821,
0.013005305081605911,
-0.0009715173509903252,
-0.0028383275493979454,
0.015821458771824837,
0.014202725142240524,
-0.0035035605542361736,
0.023194458335638046,
-0.007323106750845909,
0.013892282731831074,
-0.029270252212882042,
-0.02751847170293331,
-0.004482007585465908,
0.010433071292936802,
-0.019513500854372978,
-0.05676655098795891,
-0.020012427121400833,
-0.02789543755352497,
0.018216297030448914,
-0.022950539365410805,
0.03430384770035744,
-0.02543407492339611,
0.012184850871562958,
0.00724549638107419,
-0.053396034985780716,
0.000018514785551815294,
0.01683039590716362,
0.07313128560781479,
0.04361711069941521,
-0.02931460179388523,
-0.028338925912976265,
0.040734436362981796,
-0.017218448221683502,
-0.07384086400270462,
-0.016320383176207542,
0.011453094892203808,
0.00042339309584349394,
0.026165831834077835,
-0.007866380736231804,
-0.0030905616004019976,
0.04022442176938057,
-0.036986954510211945,
-0.05157773196697235,
-0.016375819221138954,
-0.00987870991230011,
0.02459144778549671,
0.0224516149610281,
-0.017717372626066208,
0.05521433800458908,
0.02831675112247467,
-0.010394265875220299,
0.02372664399445057,
-0.04031312093138695,
0.07011555880308151,
-0.04419364780187607,
-0.024369701743125916,
-0.03459211811423302,
-0.013426619581878185,
0.016664087772369385,
0.018881529569625854,
-0.006630155723541975,
-0.030423322692513466,
-0.01716301217675209,
-0.012617252767086029,
0.024524923413991928,
-0.01122580748051405,
0.006868530996143818,
0.014790346845984459,
0.008631397970020771,
-0.0050225090235471725,
-0.010482963174581528,
-0.022008124738931656,
-0.031221602112054825,
-0.0013838232262060046,
0.011896583251655102,
0.00046081244363449514,
0.03960353881120682,
-0.03729739785194397,
0.035767361521720886,
0.058363109827041626,
0.013626189902424812,
0.0040939548052847385,
-0.00815464835613966,
-0.013082915917038918,
0.08577071130275726,
-0.04033529385924339,
-0.037740886211395264,
-0.04013572633266449,
-0.0009410275379195809,
-0.049049846827983856,
-0.031509868800640106,
-0.0038029153365641832,
-0.006009271368384361,
-0.02774021588265896,
-0.01224028691649437,
-0.07761051505804062,
-0.03148769587278366,
-0.025944087654352188,
-0.03991398215293884,
-0.03900482878088951,
-0.020300693809986115,
-0.03281816095113754,
-0.0030046356841921806,
0.025611471384763718,
0.013371183536946774,
0.019546763971447945,
0.0180610753595829,
-0.021098973229527473,
0.041000526398420334,
0.052021220326423645,
-0.01169701386243105,
0.01079894881695509,
0.030667241662740707,
0.018426954746246338,
0.01663082465529442,
-0.04286317899823189,
-0.020722007378935814,
-0.014335771091282368,
-0.015167312696576118,
0.048517659306526184,
0.02372664399445057,
0.00971794594079256,
0.01224028691649437,
0.02094375342130661,
0.030667241662740707,
-0.04598977416753769,
0.0005692592822015285,
0.031177254393696785,
-0.01782824471592903,
-0.010571661405265331,
-0.017739547416567802,
-0.018471302464604378,
-0.04368363320827484,
-0.023859690874814987,
0.03705347701907158,
-0.014856870286166668,
0.012905520386993885,
0.03558996692299843,
-0.01786150597035885,
-0.011907670646905899,
0.004343417007476091,
-0.011608315631747246,
-0.034348197281360626,
-0.025788865983486176,
0.032685115933418274,
0.044038426131010056,
0.05140033736824989,
0.005981553345918655,
0.014147289097309113,
-0.012783560901880264,
-0.011076129972934723,
0.009945233352482319,
-0.006053620483726263,
0.03057854436337948,
0.012450944632291794,
-0.012484205886721611,
-0.02159789763391018,
-0.030046356841921806,
0.014568602666258812,
0.05024726688861847,
0.0044736918061971664,
-0.030733764171600342,
-0.03609997779130936,
0.03048984706401825,
-0.004542986862361431,
0.03962571173906326,
-0.012816823087632656,
0.015001004561781883,
0.023416202515363693,
0.03295120969414711,
-0.02397056296467781,
-0.022861840203404427,
-0.006929510738700628,
-0.007018208038061857,
-0.0685189962387085,
0.01739584282040596,
0.007012664806097746,
-0.015477755106985569,
-0.013149439357221127,
-0.005787527188658714,
-0.0016104181995615363,
0.033771663904190063,
0.024879714474081993,
0.033771663904190063,
-0.010560574010014534,
0.01384793408215046,
-0.015078614465892315,
0.003240239107981324,
0.006779833231121302,
-0.04159923642873764,
-0.05933878570795059,
-0.06239885464310646,
0.011708101257681847,
0.01744019240140915,
0.0011752450373023748,
0.03091116063296795,
-0.016808221116662025,
0.01326031144708395,
0.015777109190821648,
0.07494958490133286,
-0.006192210596054792,
-0.04000267758965492,
0.005892855580896139,
-0.02878241427242756,
0.037652187049388885,
0.013038567267358303,
0.013648363761603832,
0.009640335105359554,
0.016519952565431595,
0.01194093283265829,
-0.03714217618107796,
0.026210181415081024,
-0.02074418216943741,
0.016841482371091843,
0.010194695554673672,
0.008825424127280712,
-0.021952688694000244,
0.020078949630260468,
-0.01635364443063736,
-0.04958203434944153,
0.002472449326887727,
-0.033816009759902954,
-0.012916607782244682,
0.03499125689268112,
-0.003165400354191661,
-0.039825282990932465,
0.0367652103304863,
-0.034348197281360626,
-0.007943990640342236,
-0.021919427439570427,
-0.026720192283391953,
0.043129272758960724,
0.004177108872681856,
-0.030423322692513466,
-0.014102939516305923,
0.033549919724464417,
0.040579214692115784,
0.0069516850635409355,
-0.006330800708383322,
0.010616010054945946,
0.017517803236842155,
-0.013238136656582355,
0.0171186625957489,
0.0313103012740612,
-0.06741027534008026,
0.01877065747976303,
-0.028294578194618225,
-0.037652187049388885,
0.00287158926948905,
-0.04175445809960365,
0.044459737837314606,
0.021520288661122322,
-0.03020157851278782,
-0.016952354460954666,
0.005474313162267208,
0.0442601703107357,
-0.05871789902448654,
-0.022795317694544792,
-0.031265951693058014,
0.08412980288267136,
-0.02556712180376053,
-0.020544612780213356,
-0.025877563282847404,
-0.0005505495937541127,
-0.059915319085121155,
0.031132904812693596,
0.020533526316285133,
0.03933744505047798,
0.024835364893078804,
-0.046832405030727386,
0.08049319684505463,
0.008448459208011627,
-0.0023740502074360847,
0.00909706111997366,
0.030733764171600342,
-0.0002596834092400968,
0.036565642803907394,
0.0180610753595829,
0.03246337175369263,
0.048384614288806915,
0.037696536630392075,
-0.016885831952095032,
0.023904038593173027,
-0.023904038593173027,
-0.014036416076123714,
0.031022032722830772,
0.013692712411284447,
0.005305233411490917,
-0.020910490304231644,
-0.028959810733795166,
0.05530303716659546,
0.02609930746257305,
0.063507579267025,
-0.03707565367221832,
0.026365401223301888,
-0.012916607782244682,
-0.024502748623490334,
-0.02840545028448105,
-0.04210925102233887,
0.03785175830125809,
-0.015810370445251465,
-0.04816287010908127,
0.03299555554986,
-0.01919197291135788,
0.014158375561237335,
0.025633646175265312,
0.02534537762403488,
0.004387766122817993,
-0.023793166503310204,
-0.00009883214079309255,
0.0032263800967484713,
0.01181897334754467,
0.03918222337961197,
0.03341687098145485,
-0.03184248507022858,
-0.06984946876764297,
-0.005127837881445885,
-0.017562150955200195,
0.004071780480444431,
0.018648698925971985,
-0.0040939548052847385,
-0.0588952973484993,
0.05459345504641533,
-0.03483603522181511,
0.07973926514387131,
0.015732761472463608,
0.008398566395044327,
0.008032688871026039,
-0.04705414921045303,
0.006291995756328106,
-0.0449032299220562,
0.011153739877045155,
-0.02760716900229454,
0.03303990513086319,
0.006713309790939093,
0.04785242676734924,
-0.0035146477166563272,
0.014213811606168747,
0.015754934400320053,
0.03237467259168625,
0.03408210352063179,
-0.022562487050890923,
0.012062892317771912,
-0.03680955991148949,
0.03658781573176384,
-0.030733764171600342,
0.020455915480852127,
0.04856200888752937,
-0.03430384770035744,
-0.00855933129787445,
-0.020078949630260468,
-0.012096153572201729,
0.009801100008189678,
0.04317362233996391,
-0.010122628882527351,
-0.0041854241862893105,
-0.0459454283118248,
-0.010599379427731037,
0.07960622012615204,
-0.00266508967615664,
-0.003137682331725955,
0.0027246836107224226,
0.0392487458884716,
-0.02481319196522236,
0.013814671896398067,
-0.039692237973213196,
0.013315747492015362,
-0.044415391981601715,
-0.013581840321421623,
-0.004365591797977686,
-0.03326164931058884,
0.009119235910475254,
0.017739547416567802,
0.020688746124505997,
0.018426954746246338,
-0.0013290800852701068,
-0.0028286261949688196,
-0.013526404276490211,
-0.03893830627202988,
0.009401960298418999,
-0.018826093524694443,
-0.04122227057814598,
-0.01929175667464733,
0.026653669774532318,
-0.03587823361158371,
0.009673596359789371,
0.00952946301549673,
0.05796397104859352,
-0.01744019240140915,
0.0063751498237252235,
-0.03534604609012604,
0.013437706977128983,
0.01326031144708395,
0.059250086545944214,
0.01568841189146042,
0.003866666927933693,
-0.04789677634835243,
0.015854720026254654,
-0.005047455430030823,
-0.03244119510054588,
-0.010915365070104599,
0.0007719474961049855,
0.07486088573932648,
-0.027052808552980423,
0.022950539365410805,
-0.0036532378289848566,
-0.004692664369940758,
-0.014125114306807518,
-0.008753357455134392,
-0.05295254662632942,
-0.0019915413577109575,
0.01340444479137659,
-0.023460550233721733,
-0.021531375125050545,
-0.0018875986570492387,
-0.016564302146434784,
0.02122093364596367,
0.016298208385705948,
0.000495113548822701,
0.000756009598262608,
-0.008060406893491745,
-0.002403154270723462,
-0.03629954904317856,
-0.014679474756121635,
0.01122580748051405,
-0.003955364692956209,
0.007062557153403759,
0.0029547433368861675,
0.009002819657325745,
-0.0016145759727805853,
0.0031265951693058014,
0.04335101693868637,
0.03525735065340996,
0.038738735020160675,
0.073929563164711,
-0.01693017967045307,
0.02363794669508934,
-0.059250086545944214,
-0.06692244112491608,
0.041954029351472855,
-0.002631828188896179,
-0.024901889264583588,
-0.0070292954333126545,
-0.059117041528224945,
0.0073840864934027195,
-0.013482055626809597,
-0.004060693085193634,
-0.0008523297728970647,
0.008952927775681019,
0.016231685876846313,
0.027961960062384605,
-0.003251326270401478,
-0.04519149661064148,
-0.024946236982941628,
0.01943589188158512,
-0.0032707289792597294,
-0.04607847332954407,
0.013836846686899662,
-0.0214094165712595,
-0.018925879150629044,
0.005781983491033316,
-0.013360096141695976,
-0.013748148456215858,
-0.046255867928266525,
0.030268101021647453,
-0.023504899814724922,
-0.040534865111112595,
0.03607780486345291,
-0.00620329799130559,
-0.013825759291648865,
-0.02197486348450184,
-0.0019347193883731961,
0.025966262444853783,
-0.02009003609418869,
-0.01457969006150961,
0.011952019296586514,
-0.013681625947356224,
0.011275699362158775,
-0.009695771150290966,
0.029336776584386826,
-0.012617252767086029,
0.008548243902623653,
-0.007278757635504007,
-0.01995699107646942,
-0.05725438892841339,
0.004767503123730421,
-0.028095006942749023,
-0.0010227957973256707,
0.0040302034467458725,
0.01678604632616043,
-0.024281004443764687,
-0.019402628764510155,
0.015610801056027412,
-0.016386905685067177,
-0.008049319498240948,
-0.011026237159967422,
0.019325019791722298,
0.016941267997026443,
0.004712067078799009,
0.006125687155872583,
-0.026387576013803482,
0.03771871328353882,
-0.0016367504140362144,
0.0049726166762411594,
0.031554218381643295,
0.009895340539515018,
0.02094375342130661,
-0.03975876048207283,
0.009656965732574463,
-0.0208883173763752,
0.06457195430994034,
-0.025278855115175247,
0.023527074605226517,
-0.022185521200299263,
0.0019790681544691324,
-0.007212234660983086,
-0.007899641990661621,
0.023527074605226517,
-0.003766882000491023,
0.052021220326423645,
-0.03177596256136894,
-0.03558996692299843,
0.016420168802142143,
-0.03241902217268944,
-0.0027828915044665337,
-0.007151254918426275,
-0.009762294590473175,
-0.0012410753406584263,
0.0082987817004323,
-0.013437706977128983,
-0.06239885464310646,
-0.061911020427942276,
0.02155354991555214,
-0.009518375620245934,
-0.018848268315196037,
0.005274743307381868,
0.0007823417545296252,
0.02468014508485794,
0.0129498690366745,
-0.03601127862930298,
0.004091183189302683,
0.029669392853975296,
0.0018252331065014005,
-0.030888985842466354,
-0.014923393726348877,
0.0034952450077980757,
-0.010871016420423985,
-0.017661936581134796,
-0.00803823210299015,
-0.02552277222275734,
-0.009823273867368698,
-0.007799856830388308,
-0.05171078070998192,
-0.017606500536203384,
0.011796798557043076,
0.00557964202016592,
-0.012972043827176094,
-0.010532855987548828,
-0.041665758937597275,
-0.009180215187370777,
0.015965592116117477,
-0.019225234165787697,
-0.040024854242801666,
0.020588962361216545,
0.017429104074835777,
-0.003179259365424514,
0.004357276018708944,
-0.022252043709158897,
0.02698628604412079,
-0.013204875402152538,
-0.011741362512111664,
-0.008476177230477333,
-0.040823131799697876,
-0.025456249713897705,
-0.0244362261146307,
-0.020455915480852127,
0.00919684674590826,
0.003678184235468507,
-0.01267268881201744,
0.007982796058058739,
-0.021110061556100845,
0.028804589062929153,
-0.027385424822568893,
-0.009307718835771084,
0.02113223448395729,
0.04432669281959534,
0.07149037718772888,
-0.009950777515769005,
0.00999512616544962,
-0.009002819657325745,
-0.036277372390031815,
-0.00033608125522732735,
-0.021475939080119133,
0.009047169238328934,
-0.011575054377317429,
0.05357343330979347,
0.0026761770714074373,
0.03758566454052925,
0.027341077104210854,
0.028494147583842278,
-0.017451278865337372,
-0.0017850418807938695,
0.01645343005657196,
0.015954505652189255,
-0.0021079571451991796,
-0.022285304963588715,
0.024458400905132294,
-0.02216334640979767,
0.018615437671542168,
-0.020588962361216545,
-0.01307182852178812,
0.010061649605631828,
0.0018293907633051276,
0.025167983025312424,
0.008215627633035183,
-0.01843804121017456,
0.015732761472463608,
-0.01071025151759386,
0.009102605283260345,
-0.023061411455273628,
0.012251374311745167,
-0.02372664399445057,
0.007273214403539896,
-0.006103512831032276,
-0.008642485365271568,
-0.011519618332386017,
-0.0159766785800457,
0.02519015595316887,
0.020921578630805016,
0.021852904930710793,
-0.03312860429286957,
0.02680888958275318,
-0.018693046644330025,
-0.019513500854372978,
-0.022374004125595093,
0.008426284417510033,
0.02132071740925312,
0.003195890225470066,
-0.004002485424280167,
-0.016253860667347908,
-0.0005010035820305347,
0.0013748148921877146,
0.00893629714846611,
-0.023283155634999275,
0.05033596605062485,
0.010161434300243855,
0.012728124856948853,
0.003822318045422435,
0.021331805735826492,
-0.0161762498319149,
0.022750968113541603,
0.0488724522292614,
0.021963777020573616,
-0.016619738191366196,
0.03880525752902031,
-0.038450468331575394,
-0.031975533813238144,
-0.005604587960988283,
-0.00928554404526949,
0.001956893829628825,
-0.0323524996638298,
-0.011586141772568226,
0.019302845001220703,
-0.03275163844227791,
-0.04069008678197861,
0.0019111590227112174,
-0.0023158423136919737,
0.024458400905132294,
-0.054903898388147354,
-0.019369367510080338,
-0.02685323916375637,
-0.009368698112666607,
0.03871656209230423,
0.0030434411019086838,
0.0265206228941679,
0.01658647693693638,
-0.04896114766597748,
0.01924740895628929,
0.00620329799130559,
-0.01124798133969307,
-0.0254784245043993,
0.006103512831032276,
-0.018881529569625854,
0.004642772022634745,
-0.011281243525445461,
-0.026831064373254776,
-0.0006326643051579595,
-0.054992593824863434,
0.005920573603361845,
0.016276033595204353,
0.00548262894153595,
0.011009606532752514,
0.006552545353770256,
0.0265206228941679,
0.03667651489377022,
0.006685591768473387,
-0.006929510738700628,
-0.0438610315322876,
-0.02831675112247467,
0.016697349026799202,
-0.03124377690255642,
0.0004389844834804535,
0.035434745252132416,
-0.021331805735826492,
0.007666810415685177,
-0.004653859417885542,
-0.019646547734737396,
-0.004498638212680817,
-0.004800764843821526,
-0.01800563931465149,
0.03135465085506439,
-0.009507288224995136,
-0.014723824337124825,
0.009485114365816116,
0.029248077422380447,
-0.019746333360671997,
0.007888554595410824,
-0.017761722207069397,
0.0022202152758836746,
-0.013304660096764565,
0.0026235126424580812,
-0.012040717527270317,
0.03833959624171257,
0.04860635846853256,
-0.07552611827850342,
-0.026298878714442253,
0.011098303832113743,
-0.004074552096426487,
-0.041200097650289536,
0.0023920671083033085,
-0.038273073732852936,
-0.009113692678511143,
0.01914762333035469,
0.013637276366353035,
0.0037197612691670656,
-0.02836110070347786,
0.015899069607257843,
-0.004867288284003735,
-0.015233836136758327,
-0.022795317694544792,
-0.015366882085800171,
-0.04248621314764023,
-0.03767436370253563,
0.02463579550385475,
0.010804492980241776,
0.016287121921777725,
0.0016325926408171654,
0.04794112592935562,
0.005283058620989323,
-0.0053246356546878815,
-0.010893190279603004,
-0.04918289557099342,
-0.03521300107240677,
0.006314170081168413,
-0.006469390820711851,
0.013770323246717453,
-0.018238471820950508,
0.02585539035499096,
0.00903053767979145,
-0.04492540284991264,
0.02326098084449768,
-0.018493477255105972,
0.0007968937279656529,
-0.022418351843953133,
-0.01292769517749548,
0.01071025151759386,
0.04024659842252731,
0.010721338912844658,
-0.01482360903173685,
-0.03998050466179848,
-0.06403976678848267,
-0.023837516084313393,
0.023283155634999275,
-0.013005305081605911,
0.000130534652271308,
-0.0150342658162117,
-0.029558520764112473,
-0.008947383612394333,
0.0010366548085585237,
-0.01796129159629345,
-0.01092090830206871,
0.014335771091282368,
0.019125448539853096,
0.017551064491271973,
-0.030512019991874695,
0.05286385118961334,
0.014590777456760406,
-0.008825424127280712,
-0.0038500360678881407,
-0.014047503471374512,
-0.021686596795916557,
0.02718585543334484,
-0.020977014675736427,
0.030844636261463165,
0.007361912168562412,
-0.013581840321421623,
-0.027407599613070488,
0.03053419478237629,
0.012650514021515846,
0.031931184232234955,
-0.00627536466345191,
-0.014457730576395988,
-0.004470920190215111,
0.018138686195015907,
-0.01588798128068447,
0.009889797307550907,
0.0032873598393052816,
0.014679474756121635,
-0.012373333796858788,
-0.027873262763023376,
-0.0030545282643288374,
0.01470164954662323,
0.03887178376317024,
-0.011907670646905899,
-0.009169128723442554,
-0.009352067485451698,
0.012395508587360382,
0.012273549102246761,
0.008975101634860039,
-0.02949199639260769,
0.025079283863306046,
-0.011070585809648037,
-0.015987766906619072,
-0.0003485543711576611,
0.01664191298186779,
-0.028893286362290382,
-0.010804492980241776,
-0.012905520386993885,
-0.0229727141559124,
-0.021110061556100845,
0.030046356841921806,
0.007921816781163216,
0.011952019296586514,
-0.029092857614159584,
0.03818437457084656,
-0.010311111807823181,
0.0369647815823555,
-0.0296472180634737,
0.011563966982066631,
-0.0058097015134990215,
-0.0034592116717249155,
0.03133247420191765,
0.011353310197591782,
-0.020156560465693474,
0.039780933409929276,
0.001013094442896545,
-0.01292769517749548,
-0.011187002062797546,
-0.01092090830206871,
0.023371852934360504,
0.0046843490563333035,
0.014557515271008015,
0.017273884266614914,
0.039869632571935654,
0.01777280867099762,
0.0020871686283499002,
0.0244362261146307,
0.0031321386341005564,
0.0072399526834487915,
0.019513500854372978,
0.008171278983354568,
0.033305998891592026,
0.03173161298036575,
-0.0044099404476583,
0.012473118491470814,
-0.03734174743294716,
-0.00789409875869751,
0.00019177420472260565,
0.031886834651231766,
-0.02032286860048771,
-0.06333018094301224,
0.002484922530129552,
0.028095006942749023,
-0.003237467259168625,
-0.004227001219987869,
0.01584363356232643,
0.06075794994831085,
0.07375216484069824,
-0.014856870286166668,
0.05020291730761528,
0.019070012494921684,
0.00014534647925756872,
-0.04013572633266449,
0.03157639503479004,
-0.022706620395183563,
0.04789677634835243,
-0.017850419506430626,
-0.02410360984504223,
-0.002096869982779026,
-0.005804157815873623,
-0.012207025662064552,
0.0030489845667034388,
0.03791828081011772,
0.03270728886127472,
0.011347766034305096,
-0.02907068282365799,
0.04213142395019531,
-0.005546380300074816,
-0.016808221116662025,
0.01255072932690382,
0.021642247214913368,
0.01762867532670498,
0.022906189784407616,
0.01678604632616043,
-0.04882810264825821,
-0.008991733193397522,
0.03862786293029785,
0.039736583828926086,
0.024081435054540634,
-0.01654212735593319,
-0.01933610625565052,
-0.00382786151021719,
0.020256344228982925,
-0.02217443287372589,
-0.018737396225333214,
-0.014679474756121635,
0.0050252811051905155,
0.04865070804953575,
0.0043295579962432384,
-0.037896107882261276,
-0.001656153006479144,
-0.0027246836107224226,
-0.022285304963588715,
-0.004576248582452536,
-0.06745462864637375,
0.031465522944927216,
0.05818571522831917,
-0.024325354024767876,
-0.025411900132894516,
0.018227385357022285,
0.010510681197047234,
-0.06341888010501862,
-0.026698017492890358,
0.04159923642873764,
-0.01980176940560341,
0.028161531314253807,
-0.018227385357022285,
0.0031570850405842066,
0.008709008805453777,
-0.002200812567025423,
0.0027690324932336807,
0.02397056296467781,
-0.012207025662064552,
0.002371278591454029,
-0.028183704242110252,
-0.041865330189466476,
-0.028338925912976265,
-0.01276138611137867,
-0.0035091040190309286,
-0.007223321590572596,
0.04035747051239014,
0.017007790505886078,
0.0004739785217680037,
-0.0012701792875304818,
0.0005862365942448378,
0.011519618332386017,
0.040024854242801666,
0.043794505298137665,
-0.019602200016379356,
-0.0005467383889481425,
-0.014136201702058315,
-0.01006719283759594,
0.024791017174720764,
-0.009141410700976849,
0.05579087510704994,
0.0265206228941679,
0.02898198552429676,
-0.051267292350530624,
-0.010577204637229443,
0.02802848443388939,
0.04137749224901199,
-0.03332817554473877,
-0.013249224051833153,
-0.042375341057777405,
0.0022839666344225407,
0.032308150082826614,
0.019491327926516533,
0.05295254662632942,
0.04277448356151581,
0.016553213819861412,
0.013903370127081871,
-0.0030184946954250336,
0.011785711161792278,
0.009263369254767895,
0.004246403928846121,
0.02292836457490921,
-0.027407599613070488,
0.014901218935847282,
0.04131096974015236,
0.0015937874559313059,
-0.00745615316554904,
-0.017905855551362038,
0.006979403086006641,
-0.003506332403048873,
0.012872259132564068,
0.026409750804305077,
-0.02397056296467781,
0.011586141772568226,
0.004443202167749405,
-0.03341687098145485,
0.010876559652388096,
-0.03674303740262985,
-0.012794648297131062,
-0.021387241780757904,
0.0015771565958857536,
-0.018038902431726456,
-0.01900348998606205,
-0.006574719678610563,
0.004440430551767349,
0.04652196168899536,
-0.0160764642059803,
-0.004437658470124006,
-0.019546763971447945,
-0.0430184006690979,
-0.028582844883203506,
-0.00007501195068471134,
-0.011065042577683926,
-0.0007643250282853842,
-0.014679474756121635,
-0.03128812462091446,
0.01543340552598238,
-0.014291422441601753,
0.020389391109347343,
-0.014779260382056236,
-0.0064527601934969425,
0.05077945441007614,
0.0013450180413201451,
-0.022728795185685158,
0.024458400905132294,
0.01664191298186779,
-0.03317295387387276,
-0.03725304827094078,
0.03148769587278366,
-0.01541123166680336,
-0.04060138761997223,
0.03596693277359009,
0.02259574830532074,
0.0069516850635409355,
0.01904783770442009,
-0.022817492485046387,
0.010499594733119011,
0.01622059755027294,
0.036188676953315735,
0.023837516084313393,
-0.0007407646626234055,
0.006225472316145897,
0.009950777515769005,
-0.020722007378935814,
-0.024657970294356346,
0.014468817971646786,
0.025633646175265312,
0.004570705350488424,
-0.017373668029904366,
-0.03184248507022858,
0.0026997372042387724,
-0.022240957245230675,
0.021021362394094467,
-0.011386571452021599,
0.022329654544591904,
0.015145137906074524,
-0.001445495872758329,
0.004434886854141951,
0.003317849710583687,
-0.007772138807922602,
-0.028161531314253807,
0.01819412223994732,
-0.004687121137976646,
0.0037059022579342127,
0.021708769723773003,
-0.01946915313601494,
-0.03011288121342659,
-0.019912641495466232,
-0.021154409274458885,
-0.020245257765054703,
0.04669935628771782,
-0.019890466704964638,
-0.0392487458884716,
0.04148836433887482,
-0.019413717091083527,
0.0036975867114961147,
-0.004218685906380415,
0.02689758874475956,
0.0033427958842366934,
-0.0031127361580729485,
-0.011541793122887611,
0.028848938643932343,
0.02840545028448105,
-0.006319713778793812,
0.014235986396670341,
0.027828915044665337,
0.005721003748476505,
-0.002965830499306321,
0.007178972940891981,
-0.009379785507917404,
-0.013459880836308002,
0.0323524996638298,
-0.0411335751414299,
0.011015149764716625,
-0.01593233086168766,
0.03758566454052925,
0.0430184006690979,
-0.002701123245060444,
-0.0023754362482577562,
0.04290752857923508,
-0.017429104074835777,
0.010061649605631828,
-0.019491327926516533,
-0.01867087371647358,
-0.006763202138245106,
-0.012661601416766644,
-0.028893286362290382,
0.010094910860061646,
0.008681290782988071,
-0.0028300120029598475,
0.01457969006150961,
0.0007532378076575696,
0.021542461588978767,
-0.0061644925735890865,
-0.04485888034105301,
-0.036233022809028625,
-0.009817730635404587,
0.0017268339870497584,
-0.02178638055920601,
0.027451949194073677,
-0.04953768476843834,
-0.026254529133439064,
0.02660932019352913,
0.0028993072919547558,
-0.035612139850854874,
0.046167172491550446,
0.015256009995937347,
0.024924064055085182,
0.024258829653263092,
0.020067863166332245,
-0.003159856889396906,
0.012683776207268238,
-0.04319579526782036,
0.018593262881040573,
-0.009690227918326855,
-0.017739547416567802,
0.003686499549075961,
-0.03641042113304138,
-0.05592392012476921,
-0.0043295579962432384,
0.005937204696238041,
-0.011652665212750435,
-0.0023615772370249033,
-0.01103732455521822,
-0.0014607408083975315,
0.009590442292392254,
-0.01644234172999859,
0.004994791001081467,
-0.03170944005250931,
-0.006347431801259518,
0.004046834073960781,
0.016043202951550484,
0.0055352929048240185,
-0.011519618332386017,
-0.005926117300987244,
-0.0020234170369803905,
-0.006158948875963688,
0.001229295157827437,
-0.0038777540903538465,
0.00808812491595745,
-0.012229200452566147,
0.011663751676678658,
0.03233032301068306,
-0.008282151073217392,
0.005161099601536989,
-0.039115700870752335,
-0.029225902631878853,
0.01593233086168766,
-0.004628913011401892,
0.018992401659488678,
0.033682964742183685,
0.0409340038895607,
-0.052686452865600586,
-0.01084884162992239,
-0.017650848254561424,
0.033062081784009933,
-0.010205782949924469,
-0.013615102507174015,
0.00902499444782734,
-0.022817492485046387,
-0.029203729704022408,
-0.006408411543816328,
0.006131230853497982,
-0.01553319115191698,
0.030423322692513466,
-0.008237802423536777,
-0.02807283215224743,
-0.009119235910475254,
-0.035523444414138794,
-0.022750968113541603,
0.004357276018708944,
0.030223753303289413,
0.01510078925639391,
-0.002673405222594738,
-0.011325592175126076,
-0.013836846686899662,
0.0327959880232811,
0.03975876048207283,
0.03290686011314392,
-0.017617587000131607,
-0.02765151858329773,
0.022906189784407616,
0.01449099276214838,
-0.0035589965991675854,
-0.0013838232262060046,
0.02660932019352913,
-0.012473118491470814,
-0.0030628435779362917,
0.04215359687805176,
0.0150342658162117,
0.0014288650127127767,
-0.0028438710141927004,
-0.015854720026254654,
-0.01730714552104473,
-0.016896918416023254,
-0.011270156130194664,
-0.0010477419709786773,
-0.019968077540397644,
-0.017284970730543137,
-0.009207933209836483,
0.001769796945154667,
-0.011807885952293873,
-0.0009805257432162762,
-0.024236656725406647,
0.01649777777493,
-0.014690562151372433,
-0.0378074087202549,
-0.077699214220047,
0.007273214403539896,
-0.008021601475775242,
-0.019790681079030037,
0.0009375627851113677,
-0.016608649864792824,
-0.004676033742725849,
0.027718042954802513,
-0.005793070886284113,
0.03011288121342659,
0.03900482878088951,
0.020821793004870415,
-0.007167885545641184,
0.03521300107240677,
-0.003686499549075961,
0.003683727700263262,
-0.03106638230383396,
0.006286452058702707,
-0.04310709983110428,
-0.00719560356810689,
0.018615437671542168,
-0.029225902631878853,
0.024613620713353157,
0.03953701630234718,
0.0021356751676648855,
0.014546428807079792,
0.004476463887840509,
-0.01267268881201744,
0.04000267758965492,
-0.016841482371091843,
-0.018271733075380325,
0.0012958184815943241,
-0.020211996510624886,
-0.012462032027542591,
0.010283393785357475,
0.01668626070022583,
-0.02042265422642231,
0.0021509199868887663,
0.005305233411490917,
0.040290944278240204,
-0.04785242676734924,
-0.04865070804953575,
0.00601481506600976,
0.020101124420762062,
0.022950539365410805,
0.010510681197047234,
-0.023571422323584557,
-0.016375819221138954,
-0.0032707289792597294,
0.00549371587112546,
-0.003908243961632252,
-0.02685323916375637,
0.016142988577485085,
-0.003971995320171118,
-0.004925495944917202,
0.009235651232302189,
0.015122964046895504,
0.013193788006901741,
-0.009124779142439365,
-0.016985615715384483,
-0.0017018878133967519,
-0.03629954904317856,
-0.013116177171468735,
0.005308005027472973,
-0.0066634174436330795,
-0.023371852934360504,
0.025966262444853783,
-0.015987766906619072,
0.024281004443764687,
0.015588627196848392,
0.008925209753215313,
0.012639427557587624,
-0.03233032301068306,
-0.011092760600149632,
-0.015134050510823727,
-0.012972043827176094,
0.0005138231790624559,
0.02430317923426628,
-0.011281243525445461,
-0.017695197835564613,
-0.03392688184976578,
0.019679808989167213,
0.023416202515363693,
-0.0300685316324234,
-0.007500502280890942,
-0.005693285726010799,
-0.0028993072919547558,
0.008265520446002483,
0.023061411455273628,
0.004426571540534496,
0.003883297787979245,
-0.00881433766335249,
0.006846356205642223,
-0.0034425808116793633,
0.021730944514274597,
-0.017950203269720078,
-0.01838260516524315,
-0.01115928404033184,
0.014291422441601753,
-0.024702319875359535,
-0.008858686313033104,
-0.04343971610069275,
0.0005945520242676139,
-0.041200097650289536,
-0.0029547433368861675,
0.01543340552598238,
0.013360096141695976,
0.006646786350756884,
0.028471972793340683,
-0.06953902542591095,
0.005607360042631626,
-0.024791017174720764,
0.012661601416766644,
0.014335771091282368,
0.02609930746257305,
-0.007001577410846949,
-0.006641242653131485,
-0.016386905685067177,
0.010183609090745449,
-0.021686596795916557,
-0.0051666428335011005,
0.03133247420191765,
-0.01541123166680336,
-0.03567866235971451,
0.024702319875359535,
0.008503895252943039,
-0.04514714702963829,
0.00919684674590826,
-0.03763001412153244,
-0.012794648297131062,
0.005582413636147976,
-0.038206547498703,
0.016852568835020065,
0.021775294095277786,
0.010094910860061646,
0.003398231929168105,
0.017329320311546326,
-0.023992737755179405,
0.005280287005007267,
-0.018981315195560455,
-0.026831064373254776,
-0.005759809166193008,
-0.016386905685067177,
-0.010111541487276554,
0.018227385357022285,
0.002587479306384921,
0.016098638996481895,
0.03241902217268944,
0.010144803673028946,
-0.018072163686156273,
0.017218448221683502,
-0.01543340552598238,
-0.019491327926516533,
0.003123823320493102,
-0.009850991889834404,
0.006946141365915537,
0.001144062145613134,
0.025123633444309235,
-0.023704469203948975,
0.02510145865380764,
0.021952688694000244,
-0.01430250983685255,
0.0024281004443764687,
-0.008830968290567398,
-0.010122628882527351,
-0.012162677012383938,
-0.017218448221683502,
0.06044750660657883,
-0.0319533571600914,
-0.010649271309375763,
0.043750155717134476,
-0.022240957245230675,
-0.015610801056027412,
-0.0023421745281666517,
-0.013504230417311192,
0.0497150793671608,
-0.027141505852341652,
0.028804589062929153,
0.004579020664095879,
0.022606834769248962,
0.029381124302744865,
0.02439187653362751,
0.0006025209440849721,
0.002763488795608282,
0.02510145865380764,
-0.017928030341863632,
-0.030312450602650642,
0.0032624134328216314,
0.015821458771824837,
-0.004376678727567196,
0.0021994265262037516,
-0.012273549102246761,
0.008481720462441444,
0.0031349104829132557,
-0.0015674552414566278,
-0.021021362394094467,
0.002835555700585246,
0.023416202515363693,
0.024524923413991928,
0.04394972696900368,
-0.013204875402152538,
0.0032346954103559256,
-0.014524254016578197,
0.011663751676678658,
-0.017894767224788666,
-0.0013561052037402987,
0.004542986862361431,
0.0008890561875887215,
-0.0020511350594460964,
-0.017761722207069397,
-0.0005734169972129166,
0.032263800501823425,
0.00903053767979145,
-0.022484876215457916,
-0.00434896070510149,
0.0006288531003519893,
0.01338227093219757,
-0.00020182199659757316,
0.020810706540942192,
0.005854050628840923,
0.008032688871026039,
-0.03290686011314392,
-0.012938781641423702,
0.00940750353038311,
-0.0191032737493515,
0.022795317694544792,
-0.025877563282847404,
-0.034015581011772156,
0.017783895134925842,
0.01852673850953579,
0.0014205496991053224,
-0.004299068357795477
] | 2025-01-05 | 190 | 39755633 | [
"T cell treatment",
"Breast cancer",
"breast cancer",
"cancer incidence",
"cancer",
"treatment efficacy",
"treatment resistance",
"Innovative treatment approaches",
"current clinical drugs",
"current clinical trials",
"therapeutic efficacy",
"chimeric antigen receptor",
"CAR-T cell therapy",
"solid tumors",
"remarkable efficacy",
"hematologic malignancies",
"potential ways",
"terms",
"all other cancers",
"death rates",
"the treatment effects",
"tumor-associated antigens",
"The T cell-based immunotherapy",
"the intended therapeutic effects",
"barriers",
"CAR",
"women",
"detail",
"the patients immune cells",
"readers curiosity"
] | [
"Breast cancer",
"CAR T cells",
"CAR signaling",
"In vivo studies",
"T cell exhaustion",
"T cell persistence"
] | 0 | 10.1186/s12935-024-03615-8 | [
"Marei",
"Bedair",
"Hasan",
"Al-Mansoori",
"Caratelli",
"Sconocchia",
"Gaiba",
"Cenciarelli"
] | [
"Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35116, Egypt. [email protected].",
"Department of Social Sciences, College of Arts and Sciences, Qatar University, P.O. Box 2713, Doha, Qatar.",
"Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha, Qatar.",
"Biomedical Research Center, Qatar University, P.O. Box 2713, Doha, Qatar.",
"Institute of Translational Pharmacology-CNR, Rome, Italy.",
"Institute of Translational Pharmacology-CNR, Rome, Italy.",
"Institute of Translational Pharmacology-CNR, Rome, Italy.",
"Institute of Translational Pharmacology-CNR, Rome, Italy."
] | [
"39755633",
"38046195",
"33538338",
"11553815",
"17438091",
"21342044",
"32368385",
"35163586",
"17671126",
"8908700",
"36765623",
"32739874",
"33824268",
"30559421",
"37932456",
"35844304",
"20179677",
"31554797",
"37308954",
"38203786",
"32215875",
"29567707",
"30680780",
"17062687",
"17299405",
"23550147",
"29449531",
"30526160",
"25985798",
"24329791",
"21742772",
"32050611",
"30413825",
"30906625",
"11057895",
"27913999",
"24269963",
"21436443",
"11252954",
"30306401",
"25712293",
"11049052",
"0",
"1350088",
"24919843",
"29061641",
"32289441",
"11859875",
"12845624",
"31804974",
"27648353",
"23949426",
"18287027",
"27852699",
"23041612",
"32020017",
"30622177",
"31415244",
"25568918",
"18620092",
"31963783",
"24904064",
"29719259",
"29496493",
"29935762",
"29497107",
"31998790",
"31178870",
"9579575",
"21102519",
"27387327",
"33176519",
"21880146",
"20664585",
"22401771",
"18269343",
"15153937",
"30554343",
"31636668",
"23871962",
"21372142",
"31892992",
"30233206",
"26806809",
"20455858",
"20852124",
"17560245",
"15774488",
"22340594",
"33087511",
"23982827",
"28410844",
"22585577",
"22301273",
"33722905",
"30237308",
"31119045",
"21212348",
"10359807",
"29854028",
"33838601",
"37402965",
"29769134",
"29472313",
"34771738",
"32002293",
"33738341",
"35078921",
"37794509",
"30702010",
"28378631",
"36841147",
"29263152",
"34793275",
"37354072",
"32766150",
"36831412",
"27965307",
"22526592",
"32997278",
"27427982",
"23839099",
"23358903",
"36038913",
"32774215",
"36069628",
"33975311",
"36612317",
"30420973",
"30889382",
"24409448",
"29085043",
"29109077",
"24876563",
"31947775",
"33494834",
"27207799",
"28454503",
"32082514",
"34777381",
"29808007",
"27860544",
"32050092",
"31261963",
"29455927",
"30391782",
"36085201",
"37251405",
"33010818",
"33968034",
"32724475",
"36263619",
"38038865",
"32601304",
"36033472",
"38135346",
"36638788",
"38090576",
"32361713",
"37438548",
"36900394",
"37596653",
"34453686",
"37047817",
"37240385",
"34659898",
"34159300",
"35990652",
"27050072",
"35902958",
"34649148",
"36483567",
"39199630",
"35414783",
"28765140",
"31715131",
"35311430",
"37992445",
"38193564",
"35468841",
"31479522",
"36241426",
"26705740",
"30592986",
"30891590",
"31786121",
"36966454",
"34957875",
"32071339",
"31597756"
] | [] | 10.109007 | 4.202287 |
39754754 | 79 | CAR-T Cell Therapy: Pioneering Immunotherapy Paradigms in Cancer Treatment. | The world's one of the major causes of death are cancer. Cancer is still a complex disease over the years that needs to be cured. Traditional cytotoxic approaches, although they have been implemented for years for treating neoplastic diseases, yet are limited due to the intricacy and low efficiency of cancer cells. Researchers are thus compelled to seek more potent therapeutic strategies. Chimeric antigen receptor (CAR-T) cell therapy is one such innovative insight where T lymphocytes are altered genetically to target cancer cells. Despite the outstanding accomplishment in patients with haematological malignancies, CAR-T cell treatment has demonstrated minimal impact on solid tumours due to a number of obstacles, including proliferation, stability, trafficking, and fate within tumors. Furthermore, interactions between the host and tumour microenvironment with CAR-T cells significantly alter CAR-T cell activities. Designing and implementing these treatments additionally also requires a complex workforce. Overcoming these significant challenges, there is a requirement for innovative strategies for developing CAR-T cells with greater anti-tumour efficacy and reduced toxicity. In this chapter, the current advancement in CAR-T cell technology in order to increase clinical efficacy in both solid tumors and haematological, as well as possibilities to conquer the limits of CAR-T cell therapy in both solid and haematological tumours has been discussed. | [
0.030936814844608307,
0.029974550008773804,
0.08674817532300949,
0.060767024755477905,
-0.01878822036087513,
-0.030335398390889168,
0.011426894925534725,
0.01326722651720047,
0.007938684895634651,
0.011499064974486828,
0.0068621509708464146,
-0.029565587639808655,
-0.03938068822026253,
0.013700245879590511,
0.00503084110096097,
-0.049027394503355026,
0.03728776425123215,
0.006928307004272938,
0.03377549722790718,
0.02482643350958824,
0.03699908405542374,
0.026799075305461884,
0.031129267066717148,
0.006898235995322466,
-0.010921705514192581,
-0.007223000284284353,
0.01331533957272768,
0.006116395816206932,
-0.060189664363861084,
-0.053020793944597244,
0.03021511621773243,
-0.024429498240351677,
-0.013904727064073086,
-0.030239172279834747,
-0.004167809616774321,
0.01987076923251152,
0.028098132461309433,
0.01954600401222706,
0.01576911471784115,
-0.013303311541676521,
0.0474877692759037,
0.015889398753643036,
0.02202383615076542,
0.07573024183511734,
-0.05735098570585251,
-0.010608970187604427,
-0.027881624177098274,
-0.0710151419043541,
0.0035543658304959536,
-0.011258498765528202,
-0.019979024305939674,
-0.005505959037691355,
-0.010121823288500309,
0.027376433834433556,
-0.07236231863498688,
0.03471370413899422,
-0.045467015355825424,
0.034954268485307693,
0.011252484284341335,
0.020400013774633408,
-0.006934321019798517,
-0.002506399294361472,
-0.0006878690328449011,
-0.0232627522200346,
-0.048353809863328934,
0.01455425564199686,
-0.03849059343338013,
-0.028964171186089516,
-0.034954268485307693,
0.025981150567531586,
0.014939161948859692,
-0.01723656803369522,
-0.01983468420803547,
0.014674538746476173,
0.01659906841814518,
0.0031875022687017918,
-0.019257325679063797,
0.03497832641005516,
0.010320289991796017,
0.011781729757785797,
0.04404767230153084,
-0.04067974537611008,
0.03230804204940796,
-0.025884924456477165,
-0.02399647980928421,
0.008467930369079113,
0.0022733507212251425,
-0.01496321801096201,
-0.04799295961856842,
-0.021097656339406967,
-0.026654735207557678,
0.027256151661276817,
-0.016671238467097282,
0.035122666507959366,
-0.005731489975005388,
0.0259330365806818,
-0.0065193441696465015,
-0.014241519384086132,
0.033053796738386154,
0.0014073123456910253,
0.0615849494934082,
0.01072925329208374,
-0.028074076399207115,
0.005382669158279896,
0.04255616292357445,
-0.014782793819904327,
-0.03733587637543678,
-0.027761340141296387,
0.011312626302242279,
0.012070409953594208,
0.001879423507489264,
-0.027544831857085228,
-0.019882798194885254,
0.045683521777391434,
-0.021590817719697952,
-0.0677434429526329,
-0.02438138611614704,
0.004071583040058613,
0.007547765038907528,
0.04063163325190544,
0.00479929568246007,
0.02684718929231167,
0.022637279704213142,
-0.004835380706936121,
-0.004167809616774321,
-0.02535567805171013,
0.07957930117845535,
-0.04647739231586456,
-0.028651434928178787,
-0.06129626929759979,
0.04371087998151779,
0.013207084499299526,
0.01038043200969696,
-0.01193208433687687,
-0.0615849494934082,
-0.007704132702201605,
-0.02411676198244095,
0.02713586762547493,
0.001966628711670637,
0.008113095536828041,
0.003112325444817543,
-0.029493417590856552,
-0.02190355397760868,
0.008660383522510529,
-0.022865818813443184,
-0.02355143241584301,
0.02456180937588215,
0.03019106015563011,
-0.008383732289075851,
0.051336828619241714,
-0.031177381053566933,
0.04674201458692551,
0.06071891263127327,
0.006802009418606758,
0.010723238810896873,
-0.020748835057020187,
0.013640103861689568,
0.09290666878223419,
-0.0448174849152565,
-0.051144376397132874,
0.00002976536961796228,
-0.023310866206884384,
-0.025764640420675278,
-0.02060449682176113,
0.019100956618785858,
-0.029541529715061188,
-0.02380402572453022,
0.010500715114176273,
-0.04156984016299248,
0.003250650828704238,
-0.017982324585318565,
-0.05821702256798744,
-0.08097458630800247,
0.003969342447817326,
-0.03281323239207268,
-0.0037768895272165537,
0.016322417184710503,
0.008095053024590015,
-0.03302973881363869,
-0.0018809270113706589,
-0.0008833290776237845,
0.046068429946899414,
0.00468201981857419,
0.0015892405062913895,
0.0008705489453859627,
-0.0015576662262901664,
-0.001488503417931497,
-0.0008179250871762633,
-0.04529861733317375,
-0.024273131042718887,
-0.009033260866999626,
-0.018764164298772812,
0.023635629564523697,
0.02358751744031906,
0.00020880394731648266,
0.026991529390215874,
0.04041512310504913,
-0.00009913959365803748,
-0.0017380908830091357,
-0.020736807957291603,
0.03779295086860657,
-0.023334922268986702,
-0.03519483655691147,
-0.003575415350496769,
-0.03726370632648468,
-0.017657559365034103,
-0.018896475434303284,
0.03360709920525551,
0.003019105875864625,
-0.0003450621443334967,
0.029276907444000244,
-0.00985720008611679,
-0.006507316138595343,
0.015636803582310677,
-0.00891899224370718,
-0.03548351675271988,
-0.029493417590856552,
0.030984926968812943,
0.015552605502307415,
0.008636326529085636,
0.01077736634761095,
0.015817228704690933,
-0.0008983644656836987,
0.001965125324204564,
-0.029878323897719383,
-0.004218929912894964,
0.01859576813876629,
-0.027280207723379135,
-0.007084674667567015,
-0.008955077268183231,
-0.027761340141296387,
-0.02006322145462036,
0.03141794726252556,
-0.03983776271343231,
-0.038129743188619614,
-0.04154578596353531,
0.006922292523086071,
0.017765814438462257,
0.04650145024061203,
-0.015973595902323723,
0.009339983575046062,
0.012545527890324593,
0.02082100510597229,
-0.03853870555758476,
-0.04322974756360054,
-0.011366753838956356,
-0.01926935277879238,
-0.05075947195291519,
0.030551908537745476,
-0.008708496578037739,
0.027208037674427032,
0.0129665182903409,
0.02097737416625023,
-0.016623124480247498,
0.015540577471256256,
0.007782316766679287,
0.02932502143085003,
-0.04322974756360054,
0.025572188198566437,
-0.03218775987625122,
-0.011637390591204166,
0.011240456253290176,
-0.026582567021250725,
-0.05701419338583946,
-0.06654061377048492,
0.009869229048490524,
-0.016587039455771446,
0.017320767045021057,
0.05148116871714592,
-0.03478587418794632,
0.0316103994846344,
0.017477134242653847,
0.03764861077070236,
-0.03399200364947319,
-0.05369437858462334,
0.009520407766103745,
-0.022108035162091255,
0.04628494009375572,
-0.005686383694410324,
0.025211337953805923,
-0.003512266557663679,
0.021398363634943962,
0.004128717351704836,
-0.02831464260816574,
-0.014626425690948963,
-0.013964868150651455,
-0.0237077996134758,
0.030046720057725906,
-0.01241321675479412,
-0.044167954474687576,
0.017308738082647324,
0.014542227610945702,
-0.03312596678733826,
0.006005133967846632,
-0.006131431087851524,
0.009742931462824345,
-0.01967831514775753,
0.0042850854806602,
-0.039404746145009995,
-0.005902893375605345,
-0.03408823162317276,
-0.0043963473290205,
-0.023527374491095543,
-0.0412571057677269,
0.030239172279834747,
0.0018102606991305947,
0.010723238810896873,
-0.03218775987625122,
0.029589643701910973,
0.0378410667181015,
0.020700722932815552,
-0.02002713643014431,
0.04782456159591675,
0.011715574190020561,
-0.0025274488143622875,
0.01901675947010517,
0.04005427286028862,
-0.08997176587581635,
-0.001258461968973279,
-0.06052645668387413,
-0.05393494293093681,
-0.01456628367304802,
-0.033655211329460144,
0.031658511608839035,
0.027568887919187546,
-0.03545945882797241,
0.02694341540336609,
0.004140745848417282,
0.04650145024061203,
-0.024525724351406097,
-0.0012968021910637617,
-0.030864644795656204,
0.041786350309848785,
-0.01866793818771839,
-0.018162749707698822,
-0.023226667195558548,
-0.014662510715425014,
-0.033631157130002975,
0.044360410422086716,
0.01167948916554451,
0.011559206061065197,
0.01615402102470398,
-0.03468964621424675,
0.047343429177999496,
0.021662987768650055,
-0.024417471140623093,
0.004435439594089985,
0.017573362216353416,
0.0063208770006895065,
0.04161795601248741,
-0.01042854506522417,
0.02485048957169056,
0.019221240654587746,
0.02802596427500248,
-0.014397887513041496,
0.04301323741674423,
-0.007511680014431477,
-0.011029960587620735,
0.011300597339868546,
-0.017705673351883888,
0.015203784219920635,
-0.016526898369193077,
-0.02295001596212387,
0.04621277004480362,
0.05157739669084549,
0.08463118970394135,
-0.029733983799815178,
0.022108035162091255,
-0.04005427286028862,
-0.031345777213573456,
-0.019413692876696587,
-0.006344933994114399,
0.007890571840107441,
-0.006441160105168819,
-0.02145850658416748,
0.015360152348876,
-0.012629725970327854,
0.03793729096651077,
0.028988229110836983,
0.009285856038331985,
0.02663067914545536,
0.009303898550570011,
-0.01973845809698105,
-0.021217940375208855,
-0.004480545874685049,
0.034833986312150955,
0.024549782276153564,
-0.010590927675366402,
-0.06572268903255463,
-0.009550478309392929,
0.006411089561879635,
-0.02165095880627632,
0.009225714020431042,
0.02732832171022892,
-0.019257325679063797,
0.0659632533788681,
-0.048425979912281036,
0.10459818691015244,
0.03637361153960228,
-0.011883970350027084,
0.019401665776968002,
-0.052732113748788834,
-0.03360709920525551,
-0.022192232310771942,
0.020748835057020187,
-0.019353551790118217,
0.03091275878250599,
0.022986100986599922,
0.037311818450689316,
-0.01729671098291874,
0.0002571051300037652,
0.027087755501270294,
0.041786350309848785,
0.045058052986860275,
0.008666398003697395,
-0.04007833078503609,
-0.011210385710000992,
0.030070776119828224,
-0.02056841179728508,
0.005247350316494703,
0.02403256483376026,
-0.020099306479096413,
0.005361619405448437,
0.005063918884843588,
0.014686566777527332,
0.032332099974155426,
0.030864644795656204,
0.011799772270023823,
-0.011481022462248802,
-0.058890607208013535,
-0.03040756843984127,
0.08357270061969757,
-0.002255308208987117,
-0.0039512999355793,
-0.013038688339293003,
0.06586702913045883,
-0.026558509096503258,
0.006242692936211824,
-0.01857171207666397,
0.02145850658416748,
-0.04907550662755966,
-0.009345997124910355,
0.0072350287809967995,
-0.02043609879910946,
0.043085407465696335,
0.012437272816896439,
0.006236678920686245,
0.05335758626461029,
0.000046750661567784846,
-0.025524074211716652,
-0.01990685425698757,
-0.02913256734609604,
0.00976097397506237,
0.00445949612185359,
-0.04472125694155693,
-0.007000476587563753,
0.004372290801256895,
-0.07515288144350052,
0.005421760957688093,
0.018234917894005775,
0.025572188198566437,
-0.03370332717895508,
0.006278777960687876,
-0.03550757095217705,
-0.004627892281860113,
0.049460411071777344,
0.053405698388814926,
-0.05018211156129837,
0.013555905781686306,
-0.02345520630478859,
0.03127360716462135,
-0.016021709889173508,
-0.012798122130334377,
-0.004194873385131359,
0.004197880160063505,
0.04881088435649872,
-0.004306135233491659,
0.035435400903224945,
0.007409439422190189,
0.012112508527934551,
-0.016238220036029816,
-0.0184754841029644,
-0.026173602789640427,
-0.004252007696777582,
0.018210861831903458,
-0.02361157350242138,
-0.010230078361928463,
-0.004877479746937752,
-0.015287982299923897,
0.035411346703767776,
0.019149070605635643,
-0.012641754001379013,
0.02405662089586258,
-0.011017932556569576,
-0.005719461478292942,
-0.027448603883385658,
-0.017597418278455734,
-0.005466867238283157,
-0.01615402102470398,
0.017320767045021057,
0.011462979950010777,
0.005533022806048393,
-0.0002170734223909676,
0.02922879531979561,
0.05297267809510231,
0.015059445053339005,
0.030479738488793373,
0.05504154786467552,
0.025524074211716652,
0.02951747365295887,
-0.04342219978570938,
-0.02438138611614704,
0.05552268028259277,
-0.0043422202579677105,
-0.02525945194065571,
-0.028795775026082993,
-0.045370787382125854,
-0.0032025377731770277,
-0.0016373537946492434,
-0.011914041824638844,
-0.003855073591694236,
0.014662510715425014,
-0.01907690055668354,
0.01410920824855566,
-0.008642341010272503,
-0.024321243166923523,
-0.03173068165779114,
0.017320767045021057,
-0.019497891888022423,
-0.01010979525744915,
0.0048834942281246185,
-0.002398144453763962,
-0.0075778355821967125,
0.03379955142736435,
-0.03560379892587662,
-0.03298162668943405,
-0.03396794945001602,
0.028458982706069946,
-0.03418445959687233,
-0.032163701951503754,
0.018716050311923027,
0.009526422247290611,
0.020580438897013664,
-0.009472294710576534,
-0.010663097724318504,
0.016839634627103806,
-0.022577138617634773,
-0.024357328191399574,
0.01875213533639908,
-0.023250725120306015,
0.034641534090042114,
-0.028940115123987198,
0.013098830357193947,
-0.01060295570641756,
0.025692470371723175,
-0.007974769920110703,
-0.02771322801709175,
-0.02465803734958172,
-0.01605779491364956,
-0.013207084499299526,
-0.031658511608839035,
-0.026317942887544632,
0.004850416444242001,
-0.016069822013378143,
-0.019690344110131264,
0.04022267088294029,
-0.015576662495732307,
-0.010987862013280392,
-0.03348681703209877,
0.02523539587855339,
-0.004360262770205736,
-0.010681139305233955,
0.00976097397506237,
-0.03367926925420761,
0.029373133555054665,
0.019401665776968002,
0.0024808391463011503,
0.004525651689618826,
-0.011577248573303223,
0.01281015109270811,
-0.032765116542577744,
-0.015829255804419518,
-0.03295757248997688,
0.05027833953499794,
-0.01225083414465189,
0.014385859481990337,
-0.0325004942715168,
-0.008702483028173447,
-0.020159447565674782,
0.007589864078909159,
0.045683521777391434,
-0.0016208147862926126,
0.05715852975845337,
0.0046850270591676235,
-0.03288540244102478,
-0.0026161575224250555,
0.009658733382821083,
0.007559793069958687,
0.0009239246137440205,
-0.010434559546411037,
-0.009255784563720226,
0.000234927938436158,
-0.022047894075512886,
-0.03288540244102478,
-0.04063163325190544,
0.0010795408161357045,
-0.0001834317372413352,
-0.00293941842392087,
0.023912280797958374,
0.006705783307552338,
0.03719153627753258,
0.021398363634943962,
-0.022685393691062927,
-0.022035865113139153,
0.04859437420964241,
0.009514393284916878,
-0.021566761657595634,
0.0013832557015120983,
-0.005701418966054916,
-0.014385859481990337,
-0.0016178077785298228,
-0.006603542249649763,
-0.008221350610256195,
-0.004531666170805693,
0.011096116155385971,
-0.04250805079936981,
-0.032235872000455856,
-0.0007780813612043858,
0.009472294710576534,
-0.009285856038331985,
-0.00014340001507662237,
-0.03668634593486786,
-0.021314166486263275,
0.025307565927505493,
-0.013555905781686306,
-0.01954600401222706,
0.028843889012932777,
-0.028074076399207115,
-0.019497891888022423,
-0.002383108949288726,
-0.02078492008149624,
0.010362389497458935,
-0.008383732289075851,
-0.03189907968044281,
0.015336096286773682,
-0.020400013774633408,
-0.03646983578801155,
-0.022974073886871338,
0.01499930303543806,
-0.009183615446090698,
0.010945762507617474,
-0.001727566123008728,
0.028290586546063423,
-0.03788917884230614,
0.019052844494581223,
0.010891634970903397,
0.003870108863338828,
-0.008095053024590015,
0.06764721870422363,
0.07760666310787201,
-0.03538728877902031,
0.01451817061752081,
0.010224063880741596,
-0.00004127683860133402,
0.006411089561879635,
-0.002461293013766408,
0.01729671098291874,
-0.003145403228700161,
0.001983167603611946,
0.019497891888022423,
0.047944847494363785,
0.027448603883385658,
0.012262862175703049,
-0.004179838113486767,
-0.004393340554088354,
0.009803073480725288,
0.0206646379083395,
-0.035820309072732925,
-0.02355143241584301,
0.010969819501042366,
-0.016081850975751877,
0.01220272108912468,
-0.03817785903811455,
-0.037119366228580475,
0.004456488881260157,
0.009851186536252499,
0.009309912100434303,
0.026895301416516304,
0.017404966056346893,
-0.007259085308760405,
0.02161487378180027,
-0.03312596678733826,
-0.02764105796813965,
-0.0038580805994570255,
0.015287982299923897,
0.007295170333236456,
0.004182844888418913,
-0.002470314269885421,
-0.020796949043869972,
-0.0570623055100441,
0.02190355397760868,
0.012118523009121418,
0.027063699439167976,
-0.019497891888022423,
0.03764861077070236,
-0.016815578565001488,
0.004757196642458439,
-0.012136565521359444,
0.01698397472500801,
0.023984450846910477,
0.0068260664120316505,
0.013844585046172142,
0.005472881253808737,
-0.032765116542577744,
-0.005289449356496334,
0.0027695184107869864,
-0.016370531171560287,
0.0378410667181015,
0.028555208817124367,
0.006910264492034912,
0.011204371228814125,
0.020700722932815552,
-0.014975246973335743,
0.002318456768989563,
0.0316825695335865,
0.03793729096651077,
-0.023094356060028076,
0.06466419994831085,
0.004510616417974234,
0.009135501459240913,
-0.0005164655740372837,
-0.026775019243359566,
-0.0063750045374035835,
-0.031634457409381866,
-0.010224063880741596,
0.01748916320502758,
-0.04452880471944809,
-0.02316652610898018,
-0.010518757626414299,
0.00321757304482162,
0.00802889745682478,
-0.04409578815102577,
-0.016839634627103806,
0.0035784223582595587,
0.019858740270137787,
0.00958656333386898,
0.014746708795428276,
0.019858740270137787,
0.010127837769687176,
-0.026582567021250725,
0.010260148905217648,
0.008768638595938683,
-0.02279364876449108,
-0.01983468420803547,
0.018800249323248863,
-0.038129743188619614,
-0.0009885767940431833,
0.021217940375208855,
-0.019509918987751007,
-0.022420771420001984,
-0.02564435824751854,
0.008155194111168385,
-0.002229748060926795,
-0.0125214708968997,
0.0023214640095829964,
0.006850122939795256,
0.03247644007205963,
0.031057097017765045,
-0.022180205211043358,
0.005674355663359165,
-0.01366416085511446,
-0.010596941225230694,
0.011120173148810863,
0.002548498334363103,
-0.010452602058649063,
0.003975356463342905,
-0.01675543561577797,
-0.0034040119498968124,
-0.004456488881260157,
-0.0020342878997325897,
0.01946180686354637,
0.009249771013855934,
-0.011180314235389233,
0.022108035162091255,
0.0006991455447860062,
-0.03136983513832092,
0.00993538461625576,
0.018391286954283714,
-0.017862040549516678,
-0.002005720743909478,
-0.011246470734477043,
0.016358502209186554,
-0.024513697251677513,
0.03136983513832092,
-0.019028786569833755,
0.02764105796813965,
0.03745615854859352,
-0.07914628088474274,
-0.001365964999422431,
-0.00036761522642336786,
-0.010687153786420822,
-0.009454252198338509,
-0.0023425135295838118,
-0.04335002973675728,
-0.009640690870583057,
0.01665920950472355,
-0.008449887856841087,
0.0061765373684465885,
-0.021795298904180527,
0.025066999718546867,
0.0072350287809967995,
-0.01077736634761095,
-0.015155671164393425,
-0.006170523352921009,
-0.07433495670557022,
-0.02012336440384388,
0.022529026493430138,
0.002029777504503727,
0.0015892405062913895,
-0.003536323318257928,
0.04443258047103882,
-0.018547654151916504,
-0.004264036193490028,
-0.022925959900021553,
-0.052635885775089264,
-0.04893116652965546,
-0.03319813683629036,
-0.004360262770205736,
0.02072477899491787,
-0.049749091267585754,
0.022829733788967133,
-0.003831016831099987,
-0.031947191804647446,
0.02824247255921364,
-0.01144493743777275,
-0.004369283560663462,
0.013832557015120983,
-0.026269830763339996,
0.014782793819904327,
0.042387764900922775,
0.014253548346459866,
-0.030094832181930542,
-0.027905680239200592,
-0.027905680239200592,
0.011438922956585884,
0.009297884069383144,
-0.024874545633792877,
0.009724888950586319,
-0.01371227391064167,
-0.025812754407525063,
-0.019004730507731438,
0.0010614984203130007,
-0.015179728157818317,
-0.017212511971592903,
0.022649308666586876,
0.03738398849964142,
0.006850122939795256,
-0.03031134232878685,
0.04402361810207367,
0.03615710139274597,
-0.016069822013378143,
-0.016454728320240974,
-0.02602926455438137,
-0.04722314700484276,
0.04592408984899521,
-0.04751182720065117,
0.011180314235389233,
0.012653782963752747,
0.007728189695626497,
-0.023755913600325584,
0.03584436699748039,
0.0061434595845639706,
-0.004931607283651829,
-0.009496350772678852,
-0.012701896019279957,
-0.0025304558221250772,
-0.004952657036483288,
-0.03868304565548897,
-0.04077597334980965,
-0.04274861514568329,
0.029445303604006767,
-0.02151864767074585,
-0.005710440222173929,
-0.022553082555532455,
0.010759323835372925,
0.020099306479096413,
0.0023515347857028246,
-0.01898067444562912,
0.0003059701411984861,
-0.007643991149961948,
0.02082100510597229,
-0.011324654333293438,
-0.023623602464795113,
0.002467307262122631,
0.014686566777527332,
0.017368881031870842,
-0.025307565927505493,
0.029782095924019814,
-0.02295001596212387,
0.00576757499948144,
-0.0250429417937994,
-0.03757644072175026,
-0.011366753838956356,
0.028675492852926254,
-0.004657963290810585,
0.024020535871386528,
-0.02012336440384388,
0.04185852035880089,
-0.01673137955367565,
0.04034295305609703,
-0.03286134451627731,
-0.0027890645433217287,
-0.002452271757647395,
0.02151864767074585,
-0.007469580974429846,
-0.010693168267607689,
-0.0070365616120398045,
0.06610759347677231,
0.018992701545357704,
-0.011998239904642105,
-0.012677839025855064,
-0.014085151255130768,
-0.008612270466983318,
0.0042339651845395565,
0.028555208817124367,
0.013640103861689568,
0.008864864706993103,
0.0422193706035614,
-0.004020462743937969,
0.021001430228352547,
0.021855439990758896,
0.002174117136746645,
0.019726429134607315,
0.01863185316324234,
0.02535567805171013,
0.011667461134493351,
0.014530198648571968,
0.002429718617349863,
-0.007613920606672764,
-0.023034214973449707,
-0.017224540933966637,
0.04679012671113014,
-0.015552605502307415,
-0.03411228954792023,
0.012725952081382275,
0.030287286266684532,
-0.01317100040614605,
-0.027280207723379135,
0.02085709013044834,
0.052924565970897675,
0.0789538323879242,
-0.006621584761887789,
0.030744360759854317,
0.01415732130408287,
-0.01878822036087513,
-0.0033859694376587868,
0.033342476934194565,
-0.04808918386697769,
0.03367926925420761,
-0.03240427002310753,
-0.02562030218541622,
0.016141992062330246,
-0.005848765838891268,
-0.009352011606097221,
-0.015131614170968533,
0.046958524733781815,
0.017621474340558052,
-0.006765924859791994,
-0.030575964599847794,
0.03040756843984127,
-0.027544831857085228,
-0.02339506335556507,
0.016430672258138657,
0.015047416090965271,
0.016322417184710503,
0.02713586762547493,
0.03401606157422066,
-0.015239869244396687,
-0.001551652094349265,
0.02792973630130291,
0.0395490862429142,
0.039500970393419266,
-0.028579264879226685,
-0.012750009074807167,
-0.026317942887544632,
0.011733616702258587,
-0.007349297869950533,
-0.0007243298459798098,
-0.024200960993766785,
0.008185265585780144,
0.03213964402675629,
0.037720780819654465,
-0.03615710139274597,
-0.014446000568568707,
0.010151893831789494,
-0.036229271441698074,
-0.024152847006917,
-0.046260882169008255,
0.005665334407240152,
0.03425662964582443,
0.006074296776205301,
-0.027087755501270294,
0.0439995601773262,
-0.007463566493242979,
-0.039597198367118835,
-0.010416517034173012,
0.0403670109808445,
-0.019185155630111694,
0.0474155992269516,
-0.019221240654587746,
0.05533022806048393,
0.006411089561879635,
0.013700245879590511,
0.008786681108176708,
0.002578569110482931,
-0.018307087942957878,
-0.01123444177210331,
-0.03748021647334099,
-0.0404391810297966,
-0.004627892281860113,
-0.023828083649277687,
0.0002304173249285668,
-0.0006551670376211405,
0.05027833953499794,
0.026799075305461884,
0.006735853850841522,
0.0038971726316958666,
-0.02088114619255066,
0.0061224098317325115,
0.020652608945965767,
0.013507792726159096,
-0.001011881628073752,
0.00785448681563139,
-0.019161099568009377,
-0.012569584883749485,
0.011829843744635582,
-0.003025120124220848,
0.057784002274274826,
0.028266530483961105,
0.00847394485026598,
-0.03952502831816673,
-0.017765814438462257,
0.018908504396677017,
0.03673446178436279,
-0.038129743188619614,
-0.011318639852106571,
-0.007210972253233194,
-0.026702849194407463,
0.007397410925477743,
0.026366056874394417,
0.03646983578801155,
0.04053540527820587,
0.010675125755369663,
0.030527852475643158,
0.023419121280312538,
0.0020718765445053577,
0.01531203929334879,
0.016587039455771446,
0.0018177784513682127,
-0.011871942318975925,
-0.009568520821630955,
0.014939161948859692,
0.0005829971632920206,
0.00806498248130083,
-0.03904389590024948,
0.02053232677280903,
0.0032596720848232508,
0.00993538461625576,
0.019726429134607315,
-0.014638453722000122,
0.00011492674821056426,
0.0032927501015365124,
-0.01656298339366913,
0.014614397659897804,
-0.02732832171022892,
-0.012064395472407341,
-0.010302248410880566,
0.002746965503320098,
0.015275954268872738,
-0.015420294366776943,
0.011366753838956356,
0.021626902744174004,
0.008630312979221344,
-0.028795775026082993,
-0.022168176248669624,
-0.012617697939276695,
-0.03240427002310753,
-0.012762037105858326,
-0.01361604779958725,
-0.02703964151442051,
-0.023034214973449707,
-0.01174564566463232,
-0.03815380111336708,
0.013062745332717896,
0.0027905679307878017,
-0.014337746426463127,
0.0058547803200781345,
-0.005163152236491442,
0.04979720711708069,
0.0007675565429963171,
-0.013026660308241844,
0.004832373932003975,
-0.020147420465946198,
-0.03485804423689842,
-0.03240427002310753,
0.051914189010858536,
0.0017741757910698652,
-0.02780945412814617,
0.021723128855228424,
0.017152370885014534,
-0.019798599183559418,
-0.004597821738570929,
0.009183615446090698,
0.0014336243038997054,
0.01590142585337162,
0.03228398412466049,
0.007120759692043066,
0.011462979950010777,
0.011120173148810863,
0.011354724876582623,
-0.03069624863564968,
-0.015480435453355312,
-0.0005551817012019455,
0.018403315916657448,
0.005791631527245045,
-0.008022882975637913,
-0.027111811563372612,
0.010103780776262283,
-0.019570061936974525,
0.01688774861395359,
-0.012846235185861588,
0.02853115275502205,
0.014446000568568707,
0.004724118858575821,
-0.006525358650833368,
0.014181378297507763,
0.0018899482674896717,
-0.03425662964582443,
-0.001099086832255125,
0.017032086849212646,
-0.005951006431132555,
0.01692383363842964,
0.0007434999570250511,
-0.05253966152667999,
-0.02525945194065571,
-0.037023138254880905,
0.004041512496769428,
0.059275515377521515,
-0.02821841649711132,
-0.059467967599630356,
0.05176984891295433,
0.029782095924019814,
-0.01735685206949711,
-0.007343283388763666,
-0.004934614524245262,
0.00035840607597492635,
-0.0032837288454174995,
-0.013892699033021927,
0.02475426346063614,
0.03844248130917549,
-0.0171403419226408,
-0.0018704022513702512,
0.034328799694776535,
-0.010536800138652325,
-0.0035874436143785715,
-0.01015790831297636,
0.00998349767178297,
-0.004892515484243631,
0.02428515814244747,
-0.03685474395751953,
-0.00846191681921482,
0.004940628539770842,
0.024008506909012794,
0.06360570341348648,
0.018992701545357704,
-0.011763687245547771,
0.04510616511106491,
0.011210385710000992,
0.006753896363079548,
0.002141039352864027,
-0.027280207723379135,
-0.014301661401987076,
0.00047587003791704774,
-0.022132091224193573,
-0.032837286591529846,
-0.004928600043058395,
0.00904528982937336,
-0.010091752745211124,
0.0005239832680672407,
0.018547654151916504,
-0.002683816710487008,
-0.03579625114798546,
-0.013952840119600296,
-0.005157138220965862,
0.021037515252828598,
-0.016587039455771446,
0.013579962775111198,
-0.03122549317777157,
-0.027496717870235443,
0.009123473428189754,
-0.007746231742203236,
0.003933257423341274,
0.036325499415397644,
0.0068621509708464146,
0.0158051997423172,
0.018174776807427406,
0.017284682020545006,
-0.007662033662199974,
-0.0011494554346427321,
-0.06288401037454605,
0.01615402102470398,
-0.028699548915028572,
0.013555905781686306,
0.011541163548827171,
-0.014446000568568707,
-0.04322974756360054,
-0.003464153502136469,
0.0028281565755605698,
-0.006272763945162296,
0.010627012699842453,
0.0020177490077912807,
-0.0129665182903409,
0.0009344493737444282,
-0.010097766295075417,
0.0008697971934452653,
-0.02643822692334652,
0.016394587233662605,
0.0036295426543802023,
0.002849206095561385,
0.013231141492724419,
-0.02564435824751854,
-0.019594117999076843,
0.001783197047188878,
0.0064291320741176605,
0.0013005611253902316,
-0.030287286266684532,
0.018643882125616074,
0.010801422409713268,
0.015203784219920635,
0.06139249727129936,
0.017032086849212646,
0.019028786569833755,
-0.031249551102519035,
-0.00626073544844985,
-0.005340569652616978,
0.018740108236670494,
0.01929341070353985,
0.03514672443270683,
0.023912280797958374,
-0.026799075305461884,
-0.008131138049066067,
-0.023972423747181892,
-0.017441051080822945,
-0.018812278285622597,
-0.021626902744174004,
0.008672411553561687,
0.0073252408765256405,
-0.02533162198960781,
-0.01859576813876629,
-0.013195056468248367,
0.008167223073542118,
0.02076086401939392,
0.02605332061648369,
-0.02824247255921364,
-0.00749965151771903,
-0.0298302099108696,
-0.012004253454506397,
0.013676188886165619,
0.013122886419296265,
0.022300487384200096,
0.0035182808060199022,
0.010248120874166489,
-0.02314247004687786,
0.045274559408426285,
0.02037595771253109,
0.005947999656200409,
-0.034641534090042114,
-0.011414866894483566,
0.02891605906188488,
0.0025409806985408068,
-0.0066937548108398914,
0.001066009048372507,
0.006477245129644871,
-0.02713586762547493,
-0.0010329311480745673,
0.022240346297621727,
-0.022480912506580353,
-0.009327954612672329,
-0.019954966381192207,
-0.02122996747493744,
0.0039452859200537205,
-0.01530001126229763,
-0.0028807802591472864,
0.011054017581045628,
-0.032163701951503754,
-0.0016012688865885139,
-0.01983468420803547,
-0.009568520821630955,
0.01531203929334879,
0.013255198486149311,
-0.02307029999792576,
0.008335619233548641,
-0.007198943756520748,
-0.052828337997198105,
-0.07534533739089966,
-0.0004909054259769619,
0.014494114555418491,
-0.012978547252714634,
-0.011799772270023823,
-0.0014230995438992977,
0.0263420008122921,
0.03406417369842529,
-0.03757644072175026,
0.014193406328558922,
0.03827408328652382,
0.024585867300629616,
-0.00536462664604187,
0.009929370135068893,
-0.0021169825922697783,
0.011035975068807602,
-0.008997175842523575,
0.0038159815594553947,
-0.027785398066043854,
0.025860868394374847,
0.01539623737335205,
-0.005445817485451698,
0.01371227391064167,
0.02157878875732422,
0.01605779491364956,
0.01593751087784767,
-0.024682093411684036,
-0.028146246448159218,
0.03839436545968056,
-0.03507455438375473,
0.0030040706042200327,
-0.02922879531979561,
-0.02446558326482773,
-0.041184935718774796,
0.011420880444347858,
0.024297187104821205,
-0.0044865598902106285,
0.008046939969062805,
0.006477245129644871,
0.04135333001613617,
-0.025187281891703606,
-0.01021804939955473,
0.007150830700993538,
0.04549106955528259,
-0.030455682426691055,
0.0038430450949817896,
-0.017212511971592903,
-0.020989401265978813,
-0.014446000568568707,
-0.013158971443772316,
0.0027830502949655056,
-0.03355898708105087,
0.0058878581039607525,
-0.010753309354186058,
-0.0025860867463052273,
0.013243169523775578,
-0.0070365616120398045,
0.016671238467097282,
-0.006350948009639978,
-0.01938963681459427,
0.008365689776837826,
-0.03574813902378082,
-0.01780189946293831,
-0.0281221903860569,
-0.027881624177098274,
-0.01942572183907032,
0.015203784219920635,
-0.0056021856144070625,
-0.0010374417761340737,
-0.0020342878997325897,
0.019064871594309807,
0.013134915381669998,
-0.010759323835372925,
0.021506618708372116,
0.011859914287924767,
-0.013375481590628624,
0.022324543446302414,
-0.002980013843625784,
-0.02862737886607647,
-0.029854265972971916,
-0.018992701545357704,
0.006501301657408476,
0.012677839025855064,
-0.04113682359457016,
0.01993091031908989,
0.01416934933513403,
0.00926781352609396,
0.026414168998599052,
0.028555208817124367,
-0.0010622501140460372,
0.0033408631570637226,
-0.022962044924497604,
0.015733029693365097,
0.007812387775629759,
0.03221181407570839,
-0.02682313323020935,
-0.019786570221185684,
-0.003560379846021533,
-0.001935054431669414,
-0.03317407891154289,
-0.02513916976749897,
-0.03846653550863266,
0.0011411859886720777,
-0.017513219267129898,
0.015853313729166985,
-0.008894935250282288,
0.011252484284341335,
0.013519820757210255,
0.02339506335556507,
-0.048161353915929794,
0.0116313761100173,
-0.01929341070353985,
0.003975356463342905,
0.022553082555532455,
0.02275756374001503,
-0.004763211123645306,
-0.007427481934428215,
0.003425061469897628,
0.015360152348876,
-0.020387986674904823,
0.0067839669063687325,
0.020712750032544136,
0.0067839669063687325,
-0.02783351019024849,
0.015143643133342266,
0.005653305910527706,
-0.04491371288895607,
0.0014321206836029887,
-0.0215547326952219,
-0.023022186011075974,
0.02212006226181984,
-0.03189907968044281,
0.014181378297507763,
0.03685474395751953,
0.006134438328444958,
0.026582567021250725,
0.052828337997198105,
-0.020893175154924393,
0.012136565521359444,
-0.007595878094434738,
-0.0012983058113604784,
-0.002429718617349863,
-0.029589643701910973,
-0.02205992117524147,
0.0072350287809967995,
0.010085738264024258,
0.007553779054433107,
0.037817008793354034,
0.005106017924845219,
-0.00621262239292264,
0.021542703732848167,
-0.014638453722000122,
-0.010200006887316704,
0.02190355397760868,
-0.012750009074807167,
-0.014025010168552399,
0.04181040823459625,
0.015275954268872738,
0.02314247004687786,
0.025500018149614334,
0.011300597339868546,
-0.004585793241858482,
-0.011168286204338074,
0.0010133851319551468,
0.009057317860424519,
-0.029300963506102562,
-0.009833144024014473,
0.10305856168270111,
-0.02602926455438137,
-0.023503318428993225,
0.01282217912375927,
-0.02234860137104988,
-0.017922183498740196,
0.026486339047551155,
-0.004483552649617195,
0.037432100623846054,
-0.018836334347724915,
0.027953794226050377,
0.01793421059846878,
0.03507455438375473,
0.029156625270843506,
0.038298141211271286,
-0.00305068027228117,
0.014578312635421753,
0.03584436699748039,
0.002793575171381235,
-0.014446000568568707,
-0.006729839835315943,
0.007132788188755512,
-0.021638929843902588,
0.011029960587620735,
-0.036542005836963654,
-0.008359676226973534,
-0.007986797951161861,
-0.007535736542195082,
-0.0017335802549496293,
0.0028401848394423723,
0.023058271035552025,
-0.003602478886023164,
0.02939719147980213,
-0.019317466765642166,
0.02104954421520233,
-0.026173602789640427,
-0.019449777901172638,
-0.012605668976902962,
0.024176904931664467,
0.012557555921375751,
0.008888921700417995,
-0.00026180368149653077,
-0.00904528982937336,
-0.011378781870007515,
0.02256510965526104,
0.023082327097654343,
-0.01179375872015953,
0.016226191073656082,
0.017621474340558052,
-0.030768418684601784,
0.008419817313551903,
-0.022108035162091255,
0.003752832766622305,
-0.020231617614626884,
-0.01971440017223358,
-0.017765814438462257,
0.008455902338027954,
-0.016430672258138657,
0.019088929519057274,
-0.03714342415332794,
-0.030094832181930542,
0.03351087123155594,
0.022180205211043358,
-0.018812278285622597,
0.008371704258024693
] | 2025-01-04 | 1 | 39754754 | [
"cancer cells",
"solid tumours",
"CAR-T cell treatment",
"CAR-T cell therapy",
"greater anti-tumour efficacy",
"CAR-T cells",
"innovative strategies",
"haematological malignancies",
"CAR-T cell technology",
"CAR-T cell activities",
"neoplastic diseases",
"clinical efficacy",
"Cancer",
"cancer",
"Traditional cytotoxic approaches",
"years",
"Chimeric antigen receptor",
"low efficiency",
"minimal impact",
"T",
"CAR-T) cell therapy",
"tumors",
"reduced toxicity",
"proliferation",
"stability",
"both solid and haematological tumours",
"obstacles",
"both solid tumors",
"more potent therapeutic strategies",
"order"
] | [
"CAR-T cells",
"Cancer",
"T-lymphocytes",
"haematological malignancies.",
"immunotherapy"
] | 0 | 10.2174/0113892010330322241113062555 | [
"Borah",
"Hojaisa",
"Sarma",
"Mavi",
"Singh",
"Gulati",
"Goswami",
"Maru"
] | [
"Department of Zoology, Biswanath College, Biswanath Chariali, Assam -7841764, India.",
"Department of Zoology, Biswanath College, Biswanath Chariali, Assam -7841764, India.",
"Department of Zoology, Biswanath College, Biswanath Chariali, Assam -7841764, India.",
"Department of Botany & Life Sciences, Sri Aurobindo College, University of Delhi, Delhi - 110017, India.",
"Translational Oncology Laboratory, Department of Zoology, Hansraj College, University of Delhi, Delhi - 110007, India.",
"Deen Dayal Upadhyaya College, University of Delhi, Department of Zoology India.",
"Department of Zoology, Hindu College, University of Delhi, Delhi - 110007, India.",
"Department of Pharmacology, School of Pharmacy & Technology Management, SVKM's NMIMS Deemed to-be University, Shirpur - 425405, India."
] | [
"39754754"
] | [] | 9.840282 | 3.981104 |
39754193 | 80 | Risk analysis of cardiovascular toxicity in patients with lymphoma treated with CD19 CAR T cells. | Anti-CD19 chimeric antigen receptor (CAR) T cell therapy is a common, yet highly efficient, cellular immunotherapy for lymphoma. However, many recent studies have reported on its cardiovascular (CV) toxicity. This study analyzes the cardiotoxicity of CD19 CAR T cell therapy in the treatment of lymphoma for providing a more valuable reference for clinicians.
The PubMed, Embase, Cochrane library, and Web of Science databases were comprehensively searched from the time of their establishment to May 2024. The ClinicalTrials.gov English database is a comprehensive repository of the original studies of CD19 CAR T cell therapy and associated adverse outcomes, such as arrhythmia, CV events, and hypotension, in patients with lymphoma. The Cochrane Collaboration tool and the Newcastle-Ottawa Scale (NOS) were used to assess the quality of the included original studies. For RCTs, the Cochrane Collaboration tool was used to assess the risk of bias. For non-randomized studies, the risk of bias was assessed using the NOS quality assessment scale.
A risk analysis of two randomized controlled trials and nine cohort studies, totaling 1379 patients with lymphoma receiving CD19 CAR-T, is conducted. The incidences for all-cause mortality, CV events, and hypotension were found to be 17.8%, 17.8%, and 52.8%, respectively. Additionally, the incidences of heart failure (HF), cardiomyopathy, cardiac arrest, and other CV events are 3%, 0.6%, 1.3%, and 2.5%, respectively. In addition to cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) as adverse events, patients treated with CD19 CAR T cells are also at risk of CV events. The most common CV events are arrhythmia and HF. Our further analysis showed that the incidence of CV events was 28.7% in the elderly and 13.5% in adults. The incidence of CV events in the elderly was higher than that in adults, and it was statistically significant. Furthermore, the incidence of CV events and hypotension is strongly associated with patients with CRS.
Therefore, clinicians should pay close attention to the occurrence of such CV events and take timely prevention and intervention measures to further improve the safety of CD19 CAR T cell therapy. | [
0.007283731829375029,
0.026916783303022385,
0.031228454783558846,
0.03474259003996849,
0.005741624161601067,
-0.01496623083949089,
-0.00694727199152112,
-0.0231783427298069,
0.02821277640759945,
0.0010015909792855382,
-0.03279859945178032,
-0.006274352315813303,
-0.05119173601269722,
0.02990753762423992,
0.03549027815461159,
-0.028711237013339996,
0.021097276359796524,
0.008585955947637558,
0.02776416391134262,
0.03446843847632408,
-0.011682632379233837,
0.0415714792907238,
-0.004405131097882986,
-0.010691944509744644,
0.012181091122329235,
-0.03688596189022064,
0.010349254123866558,
-0.01113432738929987,
-0.005782124120742083,
-0.04595791548490524,
0.03770842030644417,
-0.01610022410750389,
-0.009638950228691101,
-0.009452028200030327,
0.005532894283533096,
0.04356531426310539,
0.05547848343849182,
0.00811241939663887,
-0.033994901925325394,
-0.05802062153816223,
0.012748087756335735,
-0.01962682232260704,
0.00972618069499731,
0.07576575875282288,
-0.07636391371488571,
-0.036237966269254684,
0.028561698272824287,
-0.05742247402667999,
0.015938226133584976,
0.013695159927010536,
-0.04924774542450905,
0.027440166100859642,
-0.03521612659096718,
0.03220044821500778,
-0.029782922938466072,
0.05061850696802139,
-0.015265305526554585,
0.0009400624549016356,
0.0005946459714323282,
-0.03409459441900253,
-0.0034362515434622765,
-0.029633386060595512,
0.023913567885756493,
-0.04705452546477318,
-0.047403447329998016,
-0.01391946617513895,
-0.03671150282025337,
-0.026144172996282578,
0.006548504810780287,
0.010741790756583214,
0.01529022864997387,
-0.015514534898102283,
0.04593299329280853,
0.02768939547240734,
0.04197024554014206,
0.01962682232260704,
-0.028486929833889008,
-0.009969179518520832,
0.022829420864582062,
0.006274352315813303,
0.029608462005853653,
0.007645114324986935,
-0.03234998509287834,
-0.03765857592225075,
-0.011676400899887085,
-0.0022087963297963142,
-0.000048239533498417586,
-0.033945053815841675,
-0.001928413170389831,
0.013558084145188332,
-0.013583006337285042,
0.011794785037636757,
-0.05762185528874397,
0.02355218678712845,
0.0011939649702981114,
-0.01730898767709732,
0.013682698830962181,
-0.040898557752370834,
0.02559586800634861,
0.015178075060248375,
0.04416346549987793,
0.027465088292956352,
0.00760149909183383,
-0.005386472214013338,
0.0234275721013546,
0.008561032824218273,
-0.06554735451936722,
-0.02360203117132187,
0.015514534898102283,
-0.01610022410750389,
0.0471043735742569,
-0.00006542274059029296,
-0.04894867166876793,
0.06031353399157524,
0.0009579758043400943,
-0.042817626148462296,
0.0001674510567681864,
-0.0018972593825310469,
-0.035913966596126556,
0.012199782766401768,
-0.05278680473566055,
0.026842014864087105,
0.04959666728973389,
-0.008224572986364365,
0.041048094630241394,
-0.030854610726237297,
0.06938549131155014,
-0.012885164469480515,
-0.035963814705610275,
-0.1065705269575119,
0.050194818526506424,
0.013445930555462837,
0.03309767693281174,
-0.03257429227232933,
-0.05911723151803017,
-0.000017742997442837805,
-0.0007768950308673084,
0.007196501363068819,
-0.042892392724752426,
-0.026218941435217857,
0.03202598914504051,
-0.016785604879260063,
-0.000947072054259479,
0.008934876881539822,
-0.03735949844121933,
-0.02184496447443962,
0.0024549104273319244,
-0.0055297790095210075,
-0.0322502963244915,
0.036337658762931824,
-0.0176329854875803,
0.06265629082918167,
0.04187055304646492,
0.002137142699211836,
0.001956451451405883,
-0.04234408959746361,
0.0128477793186903,
0.040749020874500275,
-0.033795516937971115,
-0.06554735451936722,
-0.011838400736451149,
0.005025089252740145,
-0.01268578041344881,
-0.018804363906383514,
0.003990787081420422,
-0.0445871539413929,
-0.033546287566423416,
0.013570545241236687,
-0.052537575364112854,
-0.003856826340779662,
-0.004782090894877911,
-0.03015676699578762,
-0.08882538974285126,
-0.04625699296593666,
-0.06818918883800507,
-0.011514401994645596,
-0.003211944829672575,
0.028885696083307266,
0.005673086270689964,
0.0030094459652900696,
0.01495376881211996,
-0.004330362193286419,
0.008660724386572838,
-0.03461797535419464,
-0.05408279597759247,
-0.009227721951901913,
-0.007576576434075832,
0.031203530728816986,
-0.07362239062786102,
-0.01992589794099331,
0.004495476838201284,
-0.0007243232103064656,
0.04202008992433548,
-0.0019517784239724278,
-0.018305905163288116,
-0.017819907516241074,
0.0006160641205497086,
0.03656196594238281,
-0.0652482807636261,
-0.010268254205584526,
0.022841881960630417,
-0.024574026465415955,
-0.0388050302863121,
0.008299341425299644,
-0.013583006337285042,
-0.001240695477463305,
-0.026343556120991707,
0.04678037390112877,
0.01595068722963333,
-0.014268388040363789,
0.04822590574622154,
0.01859251968562603,
-0.00638650543987751,
0.03232506290078163,
-0.003021907526999712,
-0.0036917116958647966,
-0.01413131132721901,
0.0612107589840889,
0.012517550960183144,
-0.024125413969159126,
-0.013146854937076569,
0.014804231002926826,
0.006324198096990585,
0.024898026138544083,
-0.030879532918334007,
0.006928579416126013,
0.03454320505261421,
-0.008897492662072182,
0.010006563737988472,
-0.019938359037041664,
0.017645446583628654,
0.026094326749444008,
0.027190936729311943,
-0.0302315354347229,
-0.000608275702688843,
-0.05174003913998604,
0.015439766459167004,
0.0466059148311615,
0.052687112241983414,
-0.004162132274359465,
0.00007452545833075419,
0.010311869904398918,
0.028985388576984406,
0.003654327243566513,
-0.02426248975098133,
-0.003158983774483204,
0.011321249417960644,
-0.08199650049209595,
0.04139701649546623,
0.01768283173441887,
0.004847513511776924,
0.03018169105052948,
-0.038505956530570984,
-0.007227655034512281,
0.020137742161750793,
0.012972394935786724,
0.04194532334804535,
-0.06639473140239716,
-0.005735393613576889,
0.0014735693112015724,
0.03750903531908989,
-0.013483314774930477,
-0.0034019823651760817,
-0.059416308999061584,
-0.05662493780255318,
0.029683230444788933,
-0.020112819969654083,
0.0048381672240793705,
0.0006246314151212573,
0.021757733076810837,
0.036213044077157974,
0.016897758468985558,
0.03479243442416191,
-0.02781401015818119,
-0.04179578274488449,
0.03708534687757492,
0.013234085403382778,
0.03028138168156147,
0.0016075301682576537,
0.024499258026480675,
0.020848046988248825,
0.008330495096743107,
-0.01401915866881609,
-0.04700468108057976,
0.00161843397654593,
-0.006249429192394018,
-0.012087630107998848,
-0.006112352944910526,
-0.013907005079090595,
-0.022779574617743492,
-0.013620391488075256,
-0.010511253029108047,
-0.015464689582586288,
-0.010623406618833542,
0.0152403824031353,
0.02093527652323246,
0.01091002020984888,
0.0019393168622627854,
-0.06654427200555801,
0.0034393668174743652,
-0.03449336066842079,
0.03890472277998924,
-0.01286024134606123,
-0.0030966761987656355,
0.02786385640501976,
0.016586221754550934,
0.014866538345813751,
0.0015358766540884972,
-0.014642232097685337,
0.049796052277088165,
-0.007327346596866846,
0.0345182828605175,
0.02325311116874218,
0.012959932908415794,
-0.0011410036822780967,
0.004321016371250153,
-0.0007188713061623275,
-0.04229424148797989,
0.05428218096494675,
-0.02007543481886387,
-0.006265006028115749,
-0.01886667124927044,
-0.02310357242822647,
0.015676533803343773,
-0.0023178341798484325,
-0.02983276918530464,
0.0018505288753658533,
0.005093627609312534,
-0.014293311163783073,
-0.02066112495958805,
0.015576842240989208,
-0.06360336393117905,
0.052437882870435715,
-0.020362049341201782,
0.010118717327713966,
-0.010081332176923752,
-0.026368478313088417,
-0.06101137772202492,
0.03180168196558952,
0.012349320575594902,
0.0038817492313683033,
0.028860773891210556,
-0.04496099799871445,
0.04261824116110802,
0.009501874446868896,
-0.03195121884346008,
-0.02413787506520748,
0.01496623083949089,
0.00890372321009636,
-0.0035390586126595736,
-0.015514534898102283,
-0.011296326294541359,
-0.010349254123866558,
0.026717400178313255,
-0.015589304268360138,
0.0105174845084548,
-0.0254463292658329,
0.010735560208559036,
-0.008598417043685913,
0.009078184142708778,
-0.0006624052184633911,
-0.002965830732136965,
-0.026817092671990395,
0.05328526347875595,
0.08334233611822128,
0.08055096864700317,
-0.014692078344523907,
0.06235721707344055,
-0.033396750688552856,
-0.057173244655132294,
-0.00013688149920199066,
-0.006134160794317722,
0.0023661223240196705,
0.016798067837953568,
-0.040474869310855865,
0.0395527184009552,
0.023564647883176804,
-0.014106388203799725,
0.018231136724352837,
0.021707888692617416,
0.026991553604602814,
0.00010738286073319614,
0.009034568443894386,
-0.023838799446821213,
-0.01162655558437109,
0.015526996925473213,
-0.01821867562830448,
-0.004355285316705704,
-0.06554735451936722,
0.02196957916021347,
-0.031552452594041824,
-0.000858284009154886,
-0.04124747961759567,
-0.02315341867506504,
-0.038505956530570984,
0.05802062153816223,
-0.001490703783929348,
0.12222214043140411,
0.047403447329998016,
-0.006617042701691389,
0.01886667124927044,
-0.003551520174369216,
-0.024798333644866943,
-0.029758000746369362,
0.02172034978866577,
0.011582939885556698,
0.05826985463500023,
-0.01512822974473238,
0.018031753599643707,
-0.031004147604107857,
0.02201942540705204,
0.013508237898349762,
0.040699172765016556,
-0.0033957515843212605,
0.016698375344276428,
-0.008050112053751945,
-0.007059425115585327,
0.031427837908267975,
-0.05198926851153374,
0.036213044077157974,
0.007040733005851507,
-0.03065522573888302,
0.00014408578863367438,
-0.019003748893737793,
-0.017396217212080956,
0.0015132902190089226,
0.024474335834383965,
-0.021857425570487976,
-0.004909820854663849,
-0.029134927317500114,
-0.02749001234769821,
0.054631102830171585,
-0.022355884313583374,
0.021483581513166428,
0.02086050808429718,
0.026218941435217857,
0.01644914597272873,
-0.01043025404214859,
-0.04668068140745163,
0.023365264758467674,
-0.03307275101542473,
0.006710503716021776,
0.017346372827887535,
0.015153152868151665,
0.03020661324262619,
0.007645114324986935,
0.03471766784787178,
0.021196966990828514,
0.010779174976050854,
0.014741923660039902,
-0.008212110958993435,
-0.010916251689195633,
-0.00816226564347744,
-0.017146987840533257,
-0.05338495597243309,
0.00943333562463522,
0.0117137860506773,
-0.059266772121191025,
0.027415243908762932,
0.010361716151237488,
0.009875718504190445,
-0.023901106789708138,
0.0056107789278030396,
-0.014654693193733692,
-0.0024003915023058653,
0.03247459977865219,
0.03474259003996849,
-0.02337772585451603,
0.03292321413755417,
-0.038580723106861115,
-0.008822723291814327,
-0.013445930555462837,
-0.01634945347905159,
0.024623872712254524,
0.033795516937971115,
0.021682964637875557,
0.00944579765200615,
0.0245615653693676,
0.010262023657560349,
0.006296159699559212,
-0.010903789661824703,
-0.014118850231170654,
-0.00745819229632616,
-0.022592652589082718,
0.05413264408707619,
0.04354039207100868,
-0.0007340587326325476,
0.008480032905936241,
-0.018106522038578987,
0.05159050226211548,
-0.009794718585908413,
-0.0086918780580163,
0.049920666962862015,
-0.01298485603183508,
-0.01826852187514305,
0.002716601360589266,
-0.026094326749444008,
-0.0025623906403779984,
0.026891861110925674,
-0.006346005480736494,
0.009115568362176418,
0.01861744187772274,
0.03259921446442604,
0.010492561385035515,
0.0230537261813879,
0.045384690165519714,
0.0129100875928998,
0.023290494456887245,
-0.008205880410969257,
0.004461207892745733,
-0.040225639939308167,
0.006698042154312134,
0.0243123359978199,
-0.02290418930351734,
-0.0551794059574604,
-0.018829287961125374,
-0.03195121884346008,
-0.010741790756583214,
-0.005816393066197634,
-0.0066108121536672115,
-0.015065922401845455,
-0.019277900457382202,
0.008006497286260128,
0.005698008928447962,
0.01512822974473238,
-0.008723031729459763,
-0.007352269720286131,
-0.03578935191035271,
-0.03289829194545746,
-0.022530345246195793,
0.017246680334210396,
0.002456468064337969,
0.0025546022225171328,
0.0021013161167502403,
-0.03947794809937477,
0.010978559032082558,
-0.011963015422224998,
0.0013372718822211027,
-0.04438776895403862,
-0.016611145809292793,
0.0007765056216157973,
-0.02574540488421917,
0.023813877254724503,
-0.015738841146230698,
0.003507904941216111,
0.00939595140516758,
-0.0032742524053901434,
-0.033645980060100555,
-0.011483248323202133,
-0.030904455110430717,
0.008330495096743107,
-0.045010846108198166,
-0.006236967630684376,
0.022306038066744804,
0.0015389920445159078,
-0.006542273797094822,
0.005557817406952381,
-0.05507971718907356,
-0.024823255836963654,
-0.04810129106044769,
-0.02574540488421917,
-0.02433725818991661,
-0.004828821402043104,
-0.0034424823243170977,
-0.048051442950963974,
-0.0012134360149502754,
0.02076081559062004,
-0.01881682500243187,
-0.03521612659096718,
0.03775826469063759,
-0.03444351255893707,
-0.017097141593694687,
-0.005221357569098473,
-0.008660724386572838,
0.024299874901771545,
0.021321581676602364,
-0.020237434655427933,
-0.01610022410750389,
0.011234018951654434,
0.007520499639213085,
-0.004277401138097048,
-0.018455443903803825,
-0.01834329031407833,
0.03215060383081436,
-0.03750903531908989,
0.0649990513920784,
-0.0275897029787302,
-0.01532761286944151,
-0.014903922565281391,
-0.006810195744037628,
0.04473669081926346,
0.02791370265185833,
0.02312849648296833,
0.021832503378391266,
-0.03284844383597374,
0.03063030354678631,
0.038032419979572296,
-0.01841805875301361,
-0.014118850231170654,
0.003722865367308259,
0.006866272073239088,
-0.028661390766501427,
0.0036605580244213343,
-0.03038107417523861,
-0.01874205656349659,
0.040400099009275436,
0.021633118391036987,
-0.005564047954976559,
0.006685581058263779,
0.02360203117132187,
0.03504166379570961,
0.009159183129668236,
-0.03060537949204445,
0.013508237898349762,
-0.003567097010090947,
0.011277633719146252,
-0.015539458021521568,
-0.002339641796424985,
-0.000021259957065922208,
-0.015502073802053928,
-0.01231816690415144,
-0.014181157574057579,
-0.011333710514008999,
-0.010224639438092709,
0.03269890695810318,
-0.02756478078663349,
-0.028711237013339996,
0.003268021624535322,
-0.0058973925188183784,
-0.014255926012992859,
-0.019252978265285492,
-0.011801015585660934,
0.0021293542813509703,
0.004367746878415346,
-0.0078008826822042465,
-0.017009912058711052,
0.029159849509596825,
-0.014343156479299068,
-0.03327213600277901,
0.00642388965934515,
-0.008168496191501617,
0.004694860428571701,
0.010673252865672112,
-0.017695292830467224,
0.01634945347905159,
0.003940941300243139,
-0.011963015422224998,
-0.007944189943373203,
0.005564047954976559,
0.009209029376506805,
-0.007719883229583502,
-0.04199516773223877,
0.0033054060768336058,
-0.01046763826161623,
0.012598549947142601,
-0.04189547523856163,
-0.0013559641083702445,
-0.010984789580106735,
0.027290627360343933,
0.08922415226697922,
-0.018206214532256126,
0.009134260937571526,
0.00038182735443115234,
0.020548971369862556,
-0.007265039253979921,
0.011801015585660934,
0.03668658062815666,
0.004392669536173344,
-0.009389720857143402,
0.007140424568206072,
0.07177808880805969,
0.05178988724946976,
-0.008498725481331348,
-0.0024299875367432833,
0.010156101547181606,
-0.00017923105042427778,
0.027215858921408653,
-0.013470853678882122,
-0.018455443903803825,
0.043091777712106705,
-0.007046963553875685,
-0.0028116200119256973,
-0.01891651749610901,
-0.05498002469539642,
0.009545489214360714,
0.0017819907516241074,
0.017969446256756783,
-0.004894244018942118,
0.023415109142661095,
-0.004738475661724806,
-0.001987605122849345,
-0.011190404184162617,
-0.03025645948946476,
0.0164989922195673,
-0.007364731281995773,
0.019589437171816826,
-0.0186423659324646,
-0.020872969180345535,
0.003330328967422247,
-0.028586622327566147,
0.03227521851658821,
0.009028337895870209,
0.0733233168721199,
-0.006043815053999424,
0.002046797191724181,
-0.0160005334764719,
0.025159716606140137,
-0.04373977333307266,
0.023415109142661095,
0.004352170042693615,
0.014604847878217697,
0.0050687044858932495,
-0.02537156082689762,
-0.01937759295105934,
-0.027066322043538094,
0.0037945187650620937,
-0.0005448000738397241,
0.010037717409431934,
0.01859251968562603,
-0.00754542276263237,
0.004193285945802927,
0.05183973163366318,
-0.03267398476600647,
-0.005716701038181782,
0.03461797535419464,
0.021595735102891922,
-0.02239326946437359,
0.05647540092468262,
-0.02138388901948929,
-0.004006363917142153,
0.001417492632754147,
-0.028462007641792297,
-0.016636068001389503,
-0.017620524391531944,
-0.03793272748589516,
0.015153152868151665,
-0.016822990030050278,
0.00886633899062872,
-0.01937759295105934,
-0.00992556381970644,
0.029184771701693535,
-0.024175260215997696,
-0.008941107429564,
0.007314885500818491,
0.010336793027818203,
0.0327487550675869,
0.040773943066596985,
0.013022240251302719,
-0.03279859945178032,
-0.019427437335252762,
0.01039286982268095,
0.009582873433828354,
-0.010411561466753483,
-0.0046668220311403275,
-0.010056409984827042,
-0.06016399711370468,
0.0047789751552045345,
0.031377993524074554,
-0.0003829956112895161,
-0.019203132018446922,
-0.0037509037647396326,
0.017570678144693375,
-0.004701090976595879,
0.00990064162760973,
-0.004604514688253403,
0.009084414690732956,
0.024424489587545395,
0.036163195967674255,
-0.027091244235634804,
0.017097141593694687,
-0.01509084552526474,
-0.018654827028512955,
0.027041397988796234,
-0.006022007204592228,
-0.014604847878217697,
0.006205813959240913,
-0.026368478313088417,
-0.012997317127883434,
-0.0056076631881296635,
0.001472011674195528,
0.0036075967364013195,
0.0002979071286972612,
0.009003414772450924,
0.005822623614221811,
-0.010785405524075031,
-0.02453664317727089,
-0.01846790499985218,
-0.005349087528884411,
-0.040599483996629715,
-0.030804764479398727,
-0.002588871167972684,
0.014069003984332085,
-0.03713519126176834,
-0.011645247228443623,
-0.009464489296078682,
0.018978824838995934,
0.029359232634305954,
-0.08294357359409332,
-0.01396931242197752,
0.0015475592808797956,
-0.0033739442005753517,
-0.004149670712649822,
0.0013037817552685738,
-0.040499791502952576,
0.00910933781415224,
0.030804764479398727,
-0.036262888461351395,
0.009757334366440773,
0.003090445650741458,
-0.025197099894285202,
-0.02988261543214321,
-0.026542939245700836,
0.02823770046234131,
-0.01602545566856861,
-0.010779174976050854,
0.009626489132642746,
0.042942240834236145,
0.00694727199152112,
0.022804496809840202,
-0.019888512790203094,
0.07466915249824524,
-0.004782090894877911,
0.010168562643229961,
-0.013508237898349762,
-0.014492694288492203,
-0.026817092671990395,
0.01849282719194889,
0.03053061105310917,
0.009657642804086208,
-0.0016916451277211308,
0.01775760017335415,
-0.004585822578519583,
-0.036113351583480835,
0.007732344791293144,
-0.0258201751857996,
-0.01745852455496788,
-0.02123435214161873,
0.022679882124066353,
0.03050568886101246,
0.0160005334764719,
0.02766447328031063,
0.012100091204047203,
0.007576576434075832,
-0.045185305178165436,
-0.007638883776962757,
0.0024455643724650145,
-0.01273562666028738,
0.021508503705263138,
-0.018729595467448235,
-0.02352726273238659,
-0.0093211829662323,
-0.005374010652303696,
-0.008554802276194096,
-0.02838723734021187,
0.020062973722815514,
-0.003349021077156067,
0.0012710703304037452,
-0.011165481060743332,
0.04897359386086464,
0.01955205202102661,
-0.02577032893896103,
-0.007763498462736607,
-0.011607863008975983,
-0.07342300564050674,
0.03344659507274628,
-0.03317244350910187,
0.009439566172659397,
0.014118850231170654,
-0.007969113066792488,
-0.019514668732881546,
0.0009260433143936098,
-0.02320326492190361,
0.02357710897922516,
-0.018206214532256126,
-0.030954301357269287,
0.008174726739525795,
0.0020483548287302256,
-0.0029253310058265924,
-0.045559149235486984,
-0.031402915716171265,
0.018654827028512955,
-0.02105989120900631,
0.010056409984827042,
0.026468170806765556,
0.03322229161858559,
0.015016076155006886,
-0.03411951661109924,
-0.02753985859453678,
-0.011582939885556698,
0.027415243908762932,
0.010218408890068531,
-0.007202731911092997,
-0.04152163118124008,
-0.015614227391779423,
-0.006972194649279118,
0.0014400790678337216,
-0.04246870428323746,
0.026742324233055115,
-0.0876789316534996,
0.0207857396453619,
-0.01760806329548359,
-0.009994102641940117,
0.01612514816224575,
0.023464955389499664,
-0.011919399723410606,
0.009570412337779999,
-0.050020355731248856,
0.031452760100364685,
-0.006246313918381929,
0.02773924171924591,
-0.008043881505727768,
0.0048568593338131905,
-0.020436817780137062,
0.007258808705955744,
0.00409982493147254,
0.0025982174556702375,
0.02219388447701931,
0.057023704051971436,
0.008056342601776123,
-0.012548704631626606,
-0.007333577610552311,
-0.018629902973771095,
-0.011632786132395267,
0.03005707636475563,
-0.008666954934597015,
0.009059491567313671,
0.022131577134132385,
0.018654827028512955,
0.010891328565776348,
-0.014717000536620617,
-0.000019057293684454635,
0.0016527030384168029,
0.06504889577627182,
0.01521546021103859,
0.04391423612833023,
0.023440033197402954,
0.012959932908415794,
0.008922415785491467,
-0.0010405330685898662,
0.025134792551398277,
-0.026692477986216545,
0.03466781973838806,
-0.006317967548966408,
-0.03045584261417389,
0.03952779620885849,
0.01992589794099331,
0.036188121885061264,
-0.030929379165172577,
0.006071853451430798,
0.04381454363465309,
0.06833872199058533,
-0.007788421120494604,
0.026817092671990395,
0.025944789871573448,
-0.024075567722320557,
-0.03471766784787178,
-0.015963148325681686,
-0.02433725818991661,
0.0554286353290081,
-0.03461797535419464,
-0.016561299562454224,
0.03486720472574234,
-0.005906738806515932,
-0.010480099357664585,
-0.031053993850946426,
0.016947604715824127,
-0.0030187920201569796,
0.027190936729311943,
-0.06699288636445999,
0.019165746867656708,
-0.0029642730951309204,
-0.01206893753260374,
0.003919133450835943,
-0.001819375203922391,
-0.0129100875928998,
0.019090978428721428,
0.0034611744340509176,
-0.03937825933098793,
-0.0058973925188183784,
-0.00968879647552967,
0.02214404009282589,
0.023975875228643417,
0.010299407877027988,
-0.013670236803591251,
-0.03681119531393051,
0.01088509801775217,
-0.02005051262676716,
-0.020673586055636406,
-0.005078050773590803,
0.027465088292956352,
0.0654975101351738,
0.02796354703605175,
-0.02441202849149704,
-0.017545755952596664,
0.007427038624882698,
-0.0329979844391346,
-0.06016399711370468,
-0.021246813237667084,
0.04655606672167778,
0.05144096538424492,
-0.014592385850846767,
0.007925497367978096,
0.03010692074894905,
-0.008118649944663048,
-0.01730898767709732,
0.049820974469184875,
0.04134717211127281,
0.0018520866287872195,
0.04010102525353432,
-0.06749134510755539,
0.01294747181236744,
0.003211944829672575,
0.0016573760658502579,
-0.02113465964794159,
-0.0022150271106511354,
-0.03643735125660896,
0.008093727752566338,
-0.05986492335796356,
-0.02806323952972889,
0.02587001956999302,
-0.018505288287997246,
0.00007807892689015716,
-0.012797934003174305,
0.028960466384887695,
0.028337392956018448,
0.0002466982405167073,
0.01899128593504429,
-0.00943333562463522,
0.021695425733923912,
0.038580723106861115,
-0.00918410625308752,
-0.006018891930580139,
-0.010124947875738144,
-0.0034113284200429916,
-0.02423756755888462,
0.031477682292461395,
-0.008561032824218273,
0.047777291387319565,
0.015639150515198708,
-0.0022539691999554634,
-0.023950953036546707,
-0.026069404557347298,
-0.01092248223721981,
0.035689663141965866,
-0.04727883264422417,
-0.011371094733476639,
0.024474335834383965,
-0.024499258026480675,
0.00531481858342886,
0.038605645298957825,
0.031328145414590836,
0.02831246890127659,
-0.010043947957456112,
0.006909887306392193,
0.005744739435613155,
0.010847712866961956,
0.02428741380572319,
-0.025159716606140137,
0.020972661674022675,
-0.0342690534889698,
-0.0058413161896169186,
0.0256955586373806,
0.005567163694649935,
-0.012604781426489353,
-0.021246813237667084,
0.011944322846829891,
0.011595401912927628,
0.004763398319482803,
0.008311803452670574,
-0.02073589339852333,
-0.004766514059156179,
-0.004486130550503731,
-0.005710470490157604,
0.02120942808687687,
0.007377192843705416,
-0.0036730195861309767,
0.008660724386572838,
0.002334968652576208,
0.0028287547174841166,
-0.005043781828135252,
-0.004130978602916002,
0.01841805875301361,
0.006884964648634195,
-0.016673453152179718,
-0.04874928668141365,
0.000150900668813847,
-0.01627468504011631,
-0.033596135675907135,
0.015514534898102283,
-0.03748411312699318,
-0.012835318222641945,
-0.004638783633708954,
-0.017670370638370514,
-0.009663873352110386,
-0.003458059160038829,
0.01824359782040119,
-0.006617042701691389,
0.0034705204889178276,
0.018530212342739105,
0.014866538345813751,
-0.029334310442209244,
-0.001520299818366766,
0.009352336637675762,
-0.026194019243121147,
-0.03897948935627937,
0.016710836440324783,
-0.029309386387467384,
-0.036013659089803696,
0.02813800796866417,
-0.005595202092081308,
-0.0183931365609169,
0.005872469861060381,
0.0006351457559503615,
-0.0317518375813961,
-0.00009005361789604649,
0.021882347762584686,
0.02000066637992859,
-0.016935143619775772,
-0.009751103818416595,
-0.009140491485595703,
-0.019838666543364525,
-0.015153152868151665,
0.007451961282640696,
0.008442648686468601,
-0.015963148325681686,
-0.0014143773587420583,
-0.001707221963442862,
0.004224439617246389,
-0.026617709547281265,
0.002163623459637165,
-0.0015522323083132505,
0.023614494130015373,
-0.0008224573102779686,
0.023689262568950653,
-0.0016527030384168029,
0.004520399495959282,
-0.02599463425576687,
0.00836164876818657,
0.02133404277265072,
-0.0033054060768336058,
0.015850994735956192,
0.031053993850946426,
-0.00533351069316268,
-0.025122331455349922,
-0.02073589339852333,
-0.026268787682056427,
-0.013196701183915138,
0.06265629082918167,
-0.01175117027014494,
-0.029060157015919685,
0.03546535596251488,
0.005364664364606142,
0.005140358116477728,
-0.002707255305722356,
0.023041265085339546,
0.0011612536618486047,
-0.024349721148610115,
-0.022031886503100395,
0.026792168617248535,
0.011757400818169117,
-0.011688862927258015,
-0.002986080711707473,
0.024922948330640793,
-0.020673586055636406,
-0.0008434860501438379,
-0.012461474165320396,
0.004669937305152416,
0.009240183047950268,
-0.01831836625933647,
-0.00811241939663887,
0.0008473802590742707,
0.020200049504637718,
-0.004034402314573526,
0.03683611750602722,
0.0008255726424977183,
0.0005549250054173172,
0.04025056213140488,
0.015277767553925514,
-0.01532761286944151,
-0.018056675791740417,
-0.03212568163871765,
-0.006504889577627182,
-0.029708154499530792,
-0.03987671807408333,
-0.018193751573562622,
-0.020872969180345535,
-0.015963148325681686,
-0.0029845230747014284,
-0.02466125786304474,
0.010411561466753483,
-0.01733390986919403,
-0.04463699832558632,
0.009576642885804176,
-0.009215259924530983,
0.01644914597272873,
-0.0020514701027423143,
0.002873927354812622,
0.008006497286260128,
-0.038456108421087265,
0.013470853678882122,
-0.020337125286459923,
-0.0007075780886225402,
0.027016475796699524,
0.020972661674022675,
0.015863455832004547,
0.028810927644371986,
-0.012131244875490665,
-0.015153152868151665,
-0.005673086270689964,
-0.059216924011707306,
0.011022173799574375,
-0.029683230444788933,
-0.023240650072693825,
0.015065922401845455,
0.0012235610047355294,
-0.03810718655586243,
-0.03257429227232933,
0.026842014864087105,
0.00017358444165438414,
0.012542474083602428,
0.014505155384540558,
-0.002982965437695384,
0.012785471975803375,
0.01294747181236744,
0.009165414609014988,
-0.03927856683731079,
0.019203132018446922,
-0.013333776965737343,
0.02234342321753502,
0.012754318304359913,
0.022929111495614052,
-0.036387503147125244,
-0.004903589840978384,
-0.002291353652253747,
0.015888379886746407,
-0.018131444230675697,
-0.01710960455238819,
-0.004115401767194271,
0.0043584005907177925,
0.05792093276977539,
0.004694860428571701,
0.009240183047950268,
0.00016638015222270042,
-0.005993968807160854,
-0.011439633555710316,
0.017072219401597977,
-0.000588804658036679,
0.03013184480369091,
0.03750903531908989,
-0.03284844383597374,
-0.023315418511629105,
0.008579724468290806,
-0.011931861750781536,
-0.007084348239004612,
-0.008972261101007462,
-0.0065298122353851795,
0.021832503378391266,
-0.012449013069272041,
0.0034019823651760817,
-0.01590084098279476,
-0.005140358116477728,
0.013570545241236687,
0.0021215658634901047,
-0.00010465690866112709,
-0.03264906257390976,
-0.03409459441900253,
-0.02000066637992859,
0.020274817943572998,
0.008710570633411407,
0.024050645530223846,
0.023950953036546707,
0.026667553931474686,
-0.016673453152179718,
0.0015748187433928251,
0.01874205656349659,
0.013632852584123611,
0.004252478014677763,
-0.014555001631379128,
0.0010218408424407244,
-0.008810262195765972,
-0.0031558682676404715,
0.026268787682056427,
0.02007543481886387,
0.01066702138632536,
0.0003306184953544289,
0.04498592019081116,
-0.00032049353467300534,
-0.008374110795557499,
0.007009579334408045,
0.0006912223761901259,
0.008785339072346687,
-0.008212110958993435,
-0.021446196362376213,
-0.007732344791293144,
-0.020187588408589363,
0.014430386945605278,
0.005532894283533096,
-0.00017718657909426838,
-0.006040699779987335,
-0.011844631284475327,
-0.031203530728816986,
0.009352336637675762,
-0.03008199855685234,
-0.036213044077157974,
-0.054481565952301025,
-0.0026137942913919687,
0.0073211160488426685,
-0.033670902252197266,
-0.011782323941588402,
-0.0149911530315876,
0.02022497169673443,
0.024972794577479362,
-0.0511418879032135,
0.03446843847632408,
0.045683763921260834,
0.0395527184009552,
0.004227554891258478,
0.0003313973138574511,
0.00795042049139738,
0.02224373072385788,
-0.00408113282173872,
-0.00044355058344081044,
0.001412819605320692,
0.005782124120742083,
0.02552109956741333,
-0.02428741380572319,
0.0393034890294075,
-0.01504099927842617,
-0.008255726657807827,
0.019464822486042976,
0.005215127021074295,
-0.01780744642019272,
0.042742855846881866,
-0.012125014327466488,
-0.01710960455238819,
-0.01495376881211996,
-0.02125927433371544,
-0.030705071985721588,
0.017084680497646332,
0.027465088292956352,
-0.006754118949174881,
0.0063989670015871525,
0.00800026673823595,
0.02788877859711647,
-0.0322502963244915,
-0.03252444788813591,
-0.016237299889326096,
0.0073211160488426685,
0.02421264350414276,
-0.025022640824317932,
-0.004909820854663849,
0.0162497628480196,
-0.022742189466953278,
0.006311736535280943,
-0.0023832570295780897,
-0.023776492103934288,
-0.020524047315120697,
-0.010193485766649246,
0.04027548432350159,
0.02199450135231018,
0.0224181916564703,
-0.01664852909743786,
0.034069668501615524,
-0.008131111972033978,
-0.008050112053751945,
-0.00638650543987751,
0.0006947271758690476,
-0.025408945977687836,
-0.0036231735721230507,
-0.014143773354589939,
-0.027315551415085793,
0.023240650072693825,
0.0149911530315876,
-0.0015802707057446241,
-0.0003771542978938669,
0.0018661057110875845,
-0.013134393841028214,
-0.023764031007885933,
-0.003788288217037916,
-0.016698375344276428,
0.013097009621560574,
-0.013570545241236687,
-0.024424489587545395,
-0.04907328635454178,
0.0023178341798484325,
0.003940941300243139,
-0.0074955765157938,
-0.036013659089803696,
0.00290352338925004,
-0.01826852187514305,
0.0129100875928998,
0.010330562479794025,
0.022106654942035675,
-0.01995082013309002,
0.013396084308624268,
-0.035839200019836426,
0.005015743430703878,
-0.0388050302863121,
-0.003704173257574439,
-0.00992556381970644,
-0.01990097388625145,
0.007906805723905563,
-0.0019346438348293304,
-0.02362695522606373,
-0.007364731281995773,
-0.013308854773640633,
-0.02579525113105774,
-0.003810095600783825,
-0.002986080711707473,
0.005451894830912352,
0.005426972173154354,
0.011607863008975983,
-0.004560899455100298,
-0.009103107266128063,
-0.0195271298289299,
-0.011445864103734493,
0.040599483996629715,
0.014667155221104622,
0.04025056213140488,
-0.036337658762931824,
0.012629703618586063,
-0.0025281214620918036,
0.023091111332178116,
-0.016885297372937202,
-0.015738841146230698,
0.0345182828605175,
-0.03242475539445877,
-0.02287926711142063,
0.029184771701693535,
-0.008598417043685913,
-0.04177086055278778,
-0.003878633724525571,
-0.023614494130015373,
0.012579858303070068,
0.010573560371994972,
-0.015664072707295418,
0.029384156689047813,
-0.020349586382508278,
0.005704239942133427,
0.011620325036346912,
0.004523515235632658,
-0.033695824444293976,
0.031153684481978416,
0.021857425570487976,
-0.003925364464521408,
0.028786005452275276,
0.008411495015025139,
-0.014417925849556923,
0.008299341425299644,
0.0006534485728479922,
0.01231816690415144,
0.021396350115537643,
-0.022592652589082718,
0.012959932908415794,
0.01211878377944231,
-0.03060537949204445,
0.003163656685501337,
0.018181290477514267,
-0.012386704795062542,
0.006779042072594166,
0.030854610726237297,
0.007271270267665386,
0.0012632819125428796,
0.01644914597272873,
0.004990820307284594,
-0.026418324559926987,
0.022542806342244148,
-0.02443695068359375,
-0.020262356847524643,
-0.02066112495958805,
-0.001049879239872098,
0.12810395658016205,
-0.0019143939716741443,
-0.004620091523975134,
0.01286024134606123,
0.002232161583378911,
-0.02066112495958805,
0.004448746331036091,
0.0032649061176925898,
-0.00503132026642561,
0.00689742574468255,
0.005722932051867247,
0.017446063458919525,
0.029209695756435394,
0.01947728358209133,
0.01157670933753252,
-0.029434001073241234,
0.00473535992205143,
0.04177086055278778,
0.003021907526999712,
-0.001437742612324655,
0.009333644062280655,
0.01162655558437109,
-0.022841881960630417,
-0.012224705889821053,
-0.027514934539794922,
-0.01298485603183508,
-0.0013185797724872828,
0.009159183129668236,
-0.0362878143787384,
0.02798847109079361,
0.016773143783211708,
0.01391946617513895,
0.020474201068282127,
-0.005361549090594053,
0.008131111972033978,
-0.03297306224703789,
-0.004638783633708954,
-0.005869354121387005,
0.007271270267665386,
-0.0033521365839987993,
-0.015763765200972557,
0.001432290649972856,
-0.01504099927842617,
0.0004871657583862543,
0.02022497169673443,
-0.007638883776962757,
-0.03003215231001377,
0.0069784256629645824,
0.013084547594189644,
0.006972194649279118,
-0.027415243908762932,
0.016785604879260063,
0.020823122933506966,
-0.004747821483761072,
-0.04025056213140488,
-0.02529679238796234,
0.025060024112462997,
-0.0026511785108596087,
-0.006791503168642521,
-0.01170132402330637,
-0.014231003820896149,
-0.006884964648634195,
0.026069404557347298,
0.005046897102147341,
0.015265305526554585
] | 2025-01-04 | 43 | 39754193 | [
"CV events",
"such CV events",
"CD19 CAR T cell therapy",
"CD19 CAR T cells",
"T cell therapy",
"adverse events",
"CV",
"non-randomized studies",
"many recent studies",
"associated adverse outcomes",
"Anti-CD19 chimeric antigen receptor",
"immune effector cell-associated neurotoxicity syndrome",
"patients",
"lymphoma",
"release syndrome",
"risk",
"CAR",
"Cochrane",
"hypotension",
"the included original studies",
"The most common CV events",
"close attention",
"CD19 CAR-T",
"NOS",
"the original studies",
"The Cochrane Collaboration tool",
"the Cochrane Collaboration tool",
"heart failure",
"nine cohort studies",
"HF"
] | [
"CAR-T therapy",
"CD19",
"Cardiovascular toxicity",
"Chimeric antigen receptor T cells",
"Lymphoma"
] | 0 | 10.1186/s12967-024-06035-4 | [
"Liu",
"Yuan",
"Yang",
"Yang",
"Liu",
"Xu",
"Wang",
"He",
"Wang",
"Li"
] | [
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Bao Shan North Road, Yunyan District, Guiyang, 550001, Guizhou, China.",
"Department of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, No. 4 Bei Jing Road, Yunyan District, Guiyang, 550004, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Bao Shan North Road, Yunyan District, Guiyang, 550001, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Bao Shan North Road, Yunyan District, Guiyang, 550001, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Bao Shan North Road, Yunyan District, Guiyang, 550001, Guizhou, China.",
"Fourth Medical Center, General Hospital of People's Liberation Army: Chinese PLA General Hospital, Beijing, 100089, China.",
"People's Liberation Army Joint Logistic Support Force 920, Hospital, Kunming, Yunnan, China.",
"Center of Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, Guizhou, China.",
"Clinical Medical Research Center, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Bao Shan North Road, Yunyan District, Guiyang, 550001, Guizhou, China. [email protected].\nAcademy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China. [email protected].",
"Department of Hematology Oncology, Affiliated Hospital of Guizhou Medical University, No. 4 Bei Jing Road, Yunyan District, Guiyang, 550004, Guizhou, China. [email protected]."
] | [
"39754193",
"38614113",
"25113771",
"25863751",
"35653592",
"11807147",
"21047225",
"28064239",
"36097221",
"15030777",
"38693452",
"29385370",
"30501490",
"34516954",
"36138152",
"32888407",
"36087853",
"37890589",
"38267353",
"34359816",
"32305113",
"30621018",
"33937946",
"31856966",
"22008217",
"20652370",
"34429331",
"33104402",
"30518502",
"29226797",
"29226764",
"34758610",
"32883871",
"36636447",
"21494108",
"30528964",
"29644505",
"23770775",
"36930381",
"32776016",
"36939851",
"24876563",
"27207799"
] | [] | 6.178405 | 4.615945 |
39752754 | 81 | Cbl-b inhibition improves manufacturing efficiency and antitumoral efficacy of anti-CD19 CAR-T cells. | Chimeric antigen receptor T (CAR-T) cells represent a promising approach for cancer immunotherapy, yet their efficacy is hindered by immunosuppressive signals in the tumor microenvironment. Casitas B-cell lymphoma protein b (Cbl-b) is a key negative regulator of T cell function. This study investigated whether inhibiting Cbl-b enhances the antitumor activity of human CAR-T cells. The Cbl-b inhibitor NX-1607 was shown to significantly improve CAR-T cell production and function. When applied during the manufacturing phase, NX-1607 increased the yield of anti-CD19 CAR-T cells. Treatment during the expansion phase enhanced cytokine secretion and cytotoxic activity. Notably, continuous NX-1607 treatment throughout manufacturing and expansion maximized CAR-T cell yield, cytokine production, and cytotoxicity. In vivo, NX-1607-treated CAR-T cells exhibited superior efficacy against hematological malignancies. These findings highlight Cbl-b as a therapeutic target for enhancing CAR-T cell manufacturing efficiency and antitumor efficacy, underscoring its potential for clinical applications. | [
0.02338145673274994,
0.008275045081973076,
0.043175216764211655,
0.07661942392587662,
-0.02388520911335945,
-0.02997937798500061,
0.013847032561898232,
0.030593710020184517,
-0.002853569807484746,
-0.04538681358098984,
-0.004899293649941683,
0.005418404005467892,
-0.06138400360941887,
-0.0012563079362735152,
0.03447628393769264,
-0.0045552682131528854,
0.037769101560115814,
-0.00033980212174355984,
-0.019535742700099945,
0.06315328180789948,
0.032584141939878464,
0.011592435650527477,
-0.002282241592183709,
0.03649129346013069,
-0.0333704873919487,
0.001022094045765698,
0.036565013229846954,
0.019277723506093025,
-0.0038887185510247946,
-0.014854535460472107,
0.020272940397262573,
-0.009454562328755856,
-0.029438765719532967,
-0.032707009464502335,
-0.024929571896791458,
0.027300892397761345,
0.05971302092075348,
-0.0022085218224674463,
0.0029303613118827343,
-0.010290052741765976,
0.008735793642699718,
0.004152880981564522,
0.030470842495560646,
0.054110318422317505,
-0.07789723575115204,
-0.004404756706207991,
-0.03162578493356705,
-0.041799116879701614,
0.021931635215878487,
0.033395059406757355,
-0.030470842495560646,
0.030470842495560646,
-0.047500111162662506,
0.04494449496269226,
-0.0322401188313961,
0.019326869398355484,
-0.022410813719034195,
-0.020125500857830048,
-0.026784854009747505,
-0.0019366800552234054,
-0.01694326288998127,
-0.002764491830021143,
0.008115319535136223,
-0.011801308020949364,
-0.054405197501182556,
-0.013048401102423668,
-0.03410768508911133,
-0.01655009016394615,
0.008956952951848507,
0.019093424081802368,
-0.015690026804804802,
-0.021169863641262054,
-0.015051121823489666,
0.01599719189107418,
0.043347232043743134,
-0.02148931659758091,
0.036343853920698166,
0.0035293344408273697,
0.04327351227402687,
-0.012593795545399189,
-0.0022945282980799675,
0.02166132815182209,
0.03521348163485527,
-0.025973936542868614,
0.010228619910776615,
-0.007955593056976795,
0.002500329166650772,
-0.004527623299509287,
-0.023062005639076233,
0.015223135240375996,
-0.01516170147806406,
-0.0143876438960433,
-0.07229453325271606,
0.060499366372823715,
-0.00990916695445776,
0.01651323027908802,
-0.0171152763068676,
-0.05990960821509361,
0.04305235296487808,
0.012753522023558617,
0.02169818803668022,
0.04543595761060715,
0.019498882815241814,
-0.02911931276321411,
0.032018959522247314,
0.010007460601627827,
-0.018540525808930397,
-0.031380053609609604,
0.01947430893778801,
-0.01642722450196743,
0.09214972704648972,
-0.04327351227402687,
-0.0037627804558724165,
0.054405197501182556,
-0.018221072852611542,
-0.06713414937257767,
-0.029414191842079163,
-0.0025924788787961006,
-0.0010912063298746943,
0.05347141623497009,
-0.006849796511232853,
0.017397867515683174,
0.0281855296343565,
-0.033395059406757355,
-0.022914566099643707,
-0.027472905814647675,
0.0799613893032074,
-0.001835315371863544,
-0.03260871767997742,
-0.07578393816947937,
-0.0014958971878513694,
-0.009896880947053432,
0.03371451422572136,
-0.010701654478907585,
-0.04914652183651924,
0.005946728866547346,
-0.03862916678190231,
0.009933740831911564,
-0.04147966206073761,
-0.0016863399650901556,
0.0024250736460089684,
0.025212164968252182,
0.015935759991407394,
-0.01690640300512314,
-0.07475186139345169,
-0.05922155827283859,
-0.0018230287823826075,
0.018368512392044067,
0.0019382159225642681,
0.04376497492194176,
-0.030519990250468254,
0.06580719351768494,
0.046124011278152466,
0.00209026294760406,
0.0018537453142926097,
-0.05150555446743965,
-0.03501689434051514,
0.07106586545705795,
-0.044035281985998154,
-0.05101408809423447,
0.02698143944144249,
-0.007537847850471735,
-0.024597832933068275,
-0.015849752351641655,
0.024094082415103912,
0.0041651674546301365,
0.01432621106505394,
0.016230639070272446,
-0.07283514738082886,
-0.0037781388964504004,
-0.023234017193317413,
-0.037031903862953186,
-0.06374303996562958,
-0.02946333959698677,
-0.057157404720783234,
0.021046997979283333,
0.008606784045696259,
-0.017533021047711372,
-0.02582649700343609,
-0.022373953834176064,
0.011524858884513378,
-0.018515951931476593,
0.023836063221096992,
-0.03580323979258537,
-0.027546625584363937,
0.02328316494822502,
-0.055093251168727875,
0.04152880981564522,
-0.030765721574425697,
-0.03182237222790718,
0.007685287389904261,
0.006241607945412397,
0.034205976873636246,
0.027227172628045082,
-0.005396902095526457,
0.013675019145011902,
0.027595771476626396,
0.0009238009806722403,
-0.02813638374209404,
-0.006708499975502491,
0.021071569994091988,
-0.020125500857830048,
-0.014485936611890793,
0.0074272677302360535,
-0.0030501559376716614,
-0.017766466364264488,
-0.022803986445069313,
0.0535205602645874,
-0.00036034383811056614,
-0.011617008596658707,
0.03835885971784592,
0.006419764366000891,
-0.04049673303961754,
0.038113128393888474,
-0.01680810935795307,
0.0028719997499138117,
0.01586204022169113,
0.06993550062179565,
-0.006548773963004351,
0.028627848252654076,
-0.011094827204942703,
-0.03383737802505493,
-0.010799948126077652,
-0.003111589001491666,
-0.0029365045484155416,
0.02727631852030754,
-0.005762429442256689,
-0.023442890495061874,
0.029487911611795425,
-0.004364825319498777,
0.011727588251233101,
0.029905658215284348,
0.01964632235467434,
-0.023528896272182465,
-0.021046997979283333,
-0.0031914522405713797,
0.005071306601166725,
0.03560665249824524,
0.08295932412147522,
-0.019498882815241814,
-0.03526262938976288,
0.0012716662604361773,
0.025507044047117233,
-0.002773706801235676,
0.009540568105876446,
0.011647725477814674,
-0.01535828784108162,
-0.09101935476064682,
-0.012151476927101612,
0.004076089709997177,
-0.004057659767568111,
0.044674187898635864,
-0.0022622758988291025,
-0.019707754254341125,
0.017213568091392517,
0.021292729303240776,
0.044846199452877045,
-0.029782790690660477,
0.03658958524465561,
-0.04850761592388153,
0.012065471149981022,
0.007052525877952576,
-0.05101408809423447,
-0.071360744535923,
-0.06276010721921921,
0.013711879029870033,
0.004641274455934763,
-0.00046650797594338655,
0.007611567620187998,
0.00982316117733717,
0.010818378068506718,
0.02607223019003868,
0.03590153157711029,
-0.030765721574425697,
-0.037081051617860794,
0.02911931276321411,
-0.012716662138700485,
0.03214182332158089,
-0.028062663972377777,
0.0138101726770401,
-0.01715213619172573,
0.022029927000403404,
-0.01412962470203638,
-0.026883147656917572,
-0.031846944242715836,
-0.027718637138605118,
0.03211725130677223,
-0.0012954715639352798,
0.012348063290119171,
-0.022570539265871048,
0.010136470198631287,
-0.01383474562317133,
-0.047033220529556274,
0.003894861787557602,
-0.015665452927350998,
-0.01663609780371189,
0.005532055161893368,
-0.01873711124062538,
-0.03376365825533867,
0.022054500877857208,
-0.04165167734026909,
0.04324893653392792,
-0.006462767254561186,
-0.04378955066204071,
0.008883233182132244,
0.009448418393731117,
0.0261705219745636,
-0.04366668313741684,
0.046345170587301254,
0.061482299119234085,
0.014215631410479546,
-0.006041950546205044,
-0.01415419764816761,
0.01925314962863922,
-0.006204748060554266,
-0.01094124373048544,
0.012667515315115452,
-0.07563649863004684,
0.01792619377374649,
-0.009792444296181202,
-0.014461363665759563,
-0.025973936542868614,
-0.05415946617722511,
0.0008546886965632439,
0.029954804107546806,
-0.01052964199334383,
0.0014636447886005044,
-0.014547370374202728,
-0.011125544086098671,
-0.018380798399448395,
0.02269340679049492,
-0.020358946174383163,
0.06172803044319153,
-0.01904427632689476,
-0.014289351180195808,
-0.033861953765153885,
0.007967879995703697,
-0.05057176947593689,
0.010228619910776615,
0.016930976882576942,
-0.01202861126512289,
0.037081051617860794,
-0.047500111162662506,
0.05401202663779259,
0.018859976902604103,
-0.005900654010474682,
0.008189039304852486,
0.039906974881887436,
0.02338145673274994,
0.056420207023620605,
-0.013171267695724964,
0.009024529717862606,
0.03752337023615837,
-0.015837466344237328,
0.01263065543025732,
0.06590548157691956,
-0.042266007512807846,
-0.034672871232032776,
0.005246391054242849,
-0.005184957757592201,
0.0044201151467859745,
0.02075211890041828,
-0.010769231244921684,
0.03617183864116669,
0.053127389401197433,
0.02162446826696396,
-0.00599280372262001,
0.040595024824142456,
-0.011193119920790195,
-0.03241213038563728,
0.02303743176162243,
0.002947255503386259,
-0.014289351180195808,
-0.022398527711629868,
-0.013871605508029461,
0.017877046018838882,
0.014166484586894512,
0.02195620723068714,
0.023860635235905647,
-0.026489974930882454,
0.048483043909072876,
-0.025236738845705986,
-0.02830839529633522,
-0.04069332033395767,
-0.01917942985892296,
-0.001341546420007944,
0.03292816877365112,
-0.015456580556929111,
-0.04769669845700264,
0.04447760060429573,
0.018343938514590263,
-0.01680810935795307,
0.03096230886876583,
-0.027128878980875015,
0.00729211512953043,
0.06890342384576797,
-0.004877792205661535,
0.06266181170940399,
0.05902497097849846,
0.04150423780083656,
0.0009069069055840373,
-0.024524113163352013,
-0.052734218537807465,
-0.042487166821956635,
0.0072982581332325935,
-0.039096057415008545,
0.02629338949918747,
0.01612005941569805,
0.01147571299225092,
-0.013871605508029461,
0.0267602801322937,
0.018884550780057907,
0.030986880883574486,
0.025875642895698547,
0.03152749314904213,
-0.01892141066491604,
-0.023234017193317413,
0.061531443148851395,
-0.027374612167477608,
0.0725402683019638,
0.018294792622327805,
-0.024388961493968964,
0.005077450070530176,
-0.02727631852030754,
-0.0027598843444138765,
0.0063030412420630455,
-0.0010919742053374648,
0.010732371360063553,
0.010161043144762516,
-0.019314583390951157,
0.011580148711800575,
0.061875469982624054,
0.0050528766587376595,
-0.03142920136451721,
-0.041627101600170135,
0.020997850224375725,
-0.061580590903759,
0.04268375411629677,
-0.06349730491638184,
0.04627145081758499,
-0.037941113114356995,
-0.009798587299883366,
-0.009718724526464939,
-0.055142395198345184,
0.027006013318896294,
-0.0035631228238344193,
0.028332969173789024,
0.005820791237056255,
-0.04061960056424141,
-0.0005264052888378501,
-0.05165299400687218,
-0.01642722450196743,
0.01745930127799511,
0.0013277239631861448,
-0.031158894300460815,
-0.019498882815241814,
0.05494581162929535,
-0.06035192683339119,
0.01926543563604355,
-0.00320681044831872,
0.013232700526714325,
-0.023234017193317413,
0.034255124628543854,
-0.011721445247530937,
-0.008379481732845306,
0.05902497097849846,
0.029709070920944214,
-0.007464127615094185,
0.023000571876764297,
-0.004973013419657946,
-0.01254464965313673,
-0.008434771560132504,
-0.002830532379448414,
0.009829304181039333,
-0.021329589188098907,
0.03027425706386566,
0.006708499975502491,
0.023135725408792496,
0.022251088172197342,
0.011322129517793655,
0.007636140566319227,
-0.0016479443293064833,
-0.028038090094923973,
0.005403045564889908,
0.06895256787538528,
0.09116679430007935,
0.016697529703378677,
-0.003302031895145774,
-0.02019922062754631,
0.040300145745277405,
0.013711879029870033,
-0.01809820719063282,
0.03617183864116669,
-0.012704375199973583,
0.012016324326395988,
-0.01723814196884632,
0.016930976882576942,
0.004598271567374468,
-0.006898942869156599,
0.012108474038541317,
0.010050463490188122,
0.06703585386276245,
0.03015139140188694,
-0.005218746140599251,
0.00690508633852005,
-0.001567313214763999,
0.009724867530167103,
0.03113432042300701,
-0.026858573779463768,
0.025408750399947166,
-0.020776690915226936,
-0.001105796662159264,
0.02779235690832138,
0.00958971492946148,
-0.04708236828446388,
-0.0007118566427379847,
-0.040545880794525146,
-0.009681864641606808,
-0.0007782812463119626,
-0.027571197599172592,
-0.008840230293571949,
0.005716354586184025,
-0.051751285791397095,
-0.012642942368984222,
0.005885296035557985,
-0.024008074775338173,
-0.05047347769141197,
-0.040595024824142456,
-0.02710430696606636,
-0.035238053649663925,
0.028578702360391617,
-0.034844882786273956,
-0.014227917417883873,
0.029954804107546806,
-0.002818245906382799,
0.005197244696319103,
-0.04088990390300751,
0.024954145774245262,
-0.007402694784104824,
-0.04656632989645004,
-0.00007271189679158852,
-0.02238623984158039,
0.014203344471752644,
-0.018270218744874,
0.012225196696817875,
-0.00028681603725999594,
0.006573347374796867,
-0.010093466378748417,
0.0006400566198863089,
-0.001413730438798666,
0.01334328018128872,
-0.01573917269706726,
0.018589671701192856,
0.01490368228405714,
0.03867831081151962,
-0.010130326263606548,
0.0001653895596973598,
-0.019019704312086105,
0.005129667930305004,
-0.004011584911495447,
0.0034832595847547054,
-0.01981833390891552,
-0.014203344471752644,
-0.03268243744969368,
-0.016009479761123657,
0.008397911675274372,
-0.026711134240031242,
-0.019437449052929878,
-0.03388652577996254,
0.028234675526618958,
-0.03774452954530716,
0.01306068804115057,
0.008176752366125584,
-0.009337838739156723,
0.03808855265378952,
0.027227172628045082,
-0.009903023950755596,
0.009970600716769695,
-0.03381280601024628,
-0.015001974999904633,
-0.0162552110850811,
-0.024782132357358932,
-0.014510510489344597,
0.04838474839925766,
-0.022545967251062393,
0.008932380005717278,
-0.019548028707504272,
-0.005648778285831213,
-0.01994120143353939,
0.0008462416590191424,
0.01852823793888092,
-0.008035455830395222,
0.02281627245247364,
0.019609462469816208,
-0.023578044027090073,
0.011217693798244,
0.02166132815182209,
0.007058668881654739,
-0.03410768508911133,
0.013847032561898232,
0.012126903980970383,
0.002581728156656027,
0.008465488441288471,
-0.0228654183447361,
-0.013589013367891312,
0.006450480781495571,
0.01151257287710905,
-0.010953530669212341,
0.011543288826942444,
0.0006895871483720839,
0.035582080483436584,
0.04052130505442619,
-0.01758216693997383,
-0.00829961895942688,
-0.0038887185510247946,
-0.010222475975751877,
-0.002378998789936304,
-0.02354118414223194,
0.010050463490188122,
-0.03555750846862793,
-0.027546625584363937,
-0.0013999079819768667,
-0.031208040192723274,
0.009608144871890545,
-0.0036184126511216164,
-0.015849752351641655,
-0.003854930168017745,
-0.015370574779808521,
0.02448725327849388,
0.01792619377374649,
-0.014166484586894512,
-0.019240863621234894,
-0.04359296336770058,
0.01127912662923336,
-0.02646540105342865,
-0.023442890495061874,
0.018417658284306526,
0.02298828586935997,
-0.02354118414223194,
-0.0031484488863497972,
-0.0032498135697096586,
0.006017377134412527,
-0.035188909620046616,
-0.015432007610797882,
-0.003486331319436431,
0.003636842593550682,
-0.03676159679889679,
0.0012831849744543433,
0.006880512926727533,
0.003965510055422783,
-0.027546625584363937,
-0.023565756157040596,
0.012839528732001781,
0.0004949208232574165,
0.006880512926727533,
-0.03329676762223244,
-0.002532581565901637,
-0.0038580019026994705,
0.06737987697124481,
0.06796963512897491,
-0.01668524369597435,
0.047033220529556274,
0.003477116348221898,
-0.014166484586894512,
-0.02612137608230114,
-0.008625213988125324,
-0.0038242137525230646,
0.003002545330673456,
0.0037781388964504004,
0.00012555399734992534,
0.08153408020734787,
0.02441353350877762,
-0.006149458233267069,
-0.03833428770303726,
-0.006524200551211834,
0.024118654429912567,
0.028849007561802864,
-0.027939796447753906,
-0.018343938514590263,
0.013330994173884392,
-0.016869543120265007,
0.01076308824121952,
-0.013908465392887592,
-0.05076835677027702,
0.002595550613477826,
0.007138532120734453,
-0.007058668881654739,
0.02338145673274994,
-0.009829304181039333,
-0.004260389134287834,
0.004211242310702801,
-0.014277064241468906,
0.0030332617461681366,
-0.022079074755311012,
-0.0003144609509035945,
-0.021120717748999596,
-0.01904427632689476,
-0.00933169573545456,
-0.010732371360063553,
-0.024266093969345093,
0.007605424150824547,
-0.0015058801509439945,
0.02732546627521515,
-0.026317961513996124,
-0.009896880947053432,
-0.03071657568216324,
-0.004647417925298214,
-0.017311861738562584,
0.022201940417289734,
0.017397867515683174,
0.026047656312584877,
0.0038580019026994705,
-0.01612005941569805,
-0.0307902954518795,
0.003661415772512555,
0.0007325903279706836,
0.008809513412415981,
0.059811316430568695,
0.012642942368984222,
0.005117381457239389,
-0.0014375357422977686,
0.01151257287710905,
-0.0009107464575208724,
-0.016439510509371758,
0.04516565427184105,
0.007832726463675499,
-0.021808767691254616,
0.06777305155992508,
-0.005163456313312054,
0.0008623678586445749,
0.005906797479838133,
-0.01646408438682556,
-0.012102331034839153,
-0.011617008596658707,
0.011125544086098671,
0.037203915417194366,
-0.03226469084620476,
-0.017471587285399437,
0.0035477643832564354,
-0.023614903911948204,
-0.005743999499827623,
-0.02784150466322899,
-0.028726141899824142,
0.02663741447031498,
0.013515293598175049,
0.002982579404488206,
0.015948045998811722,
0.008330334909260273,
0.021907061338424683,
-0.04204484820365906,
0.006072666961699724,
0.009184256196022034,
-0.019916627556085587,
0.01847909204661846,
-0.001290096202865243,
-0.030102243646979332,
-0.01464566309005022,
0.0076299975626170635,
-0.005378472153097391,
-0.012477072887122631,
-0.06472596526145935,
0.00434332387521863,
0.012409496121108532,
-0.0027368469163775444,
-0.025359604507684708,
-0.0066163502633571625,
0.0044139716774225235,
-0.015554874204099178,
-0.00026800212799571455,
0.022509107366204262,
-0.019965773448348045,
-0.015849752351641655,
0.015309141017496586,
-0.010382202453911304,
-0.006659353617578745,
0.03032340295612812,
-0.02153846248984337,
0.0035477643832564354,
0.02843126282095909,
0.007531704381108284,
-0.009485278278589249,
0.015259995125234127,
-0.005197244696319103,
0.014141911640763283,
-0.029831938445568085,
-0.0057470714673399925,
0.02062925137579441,
0.007255255244672298,
-0.037130195647478104,
-0.002251524943858385,
-0.0287752877920866,
0.0379902608692646,
-0.04602571576833725,
0.006683927029371262,
0.0071262456476688385,
0.027202598750591278,
0.013134407810866833,
-0.09883365035057068,
-0.002540260786190629,
-0.0027460618875920773,
-0.0027598843444138765,
-0.005578130017966032,
0.023737769573926926,
-0.03447628393769264,
0.0092026861384511,
0.0069849491119384766,
0.024843566119670868,
0.005547413602471352,
0.004155952483415604,
0.010806091129779816,
-0.02273026667535305,
0.012876388616859913,
0.0030931590590626,
-0.005215674638748169,
-0.038113128393888474,
0.01873711124062538,
0.033395059406757355,
-0.011272983625531197,
0.01775418035686016,
-0.01763131469488144,
0.05941814184188843,
-0.010486639104783535,
0.03255956992506981,
-0.013269560411572456,
0.029733644798398018,
-0.03464829549193382,
0.007777437102049589,
0.03432884439826012,
0.00877265352755785,
-0.04361753538250923,
0.041627101600170135,
-0.018171926960349083,
-0.021649042144417763,
0.014879109337925911,
-0.017766466364264488,
-0.006720786914229393,
0.004598271567374468,
-0.004266532137989998,
-0.007814296521246433,
-0.0022960640490055084,
0.003501689527183771,
-0.041577957570552826,
0.005043661687523127,
-0.03174865245819092,
-0.012305060401558876,
0.024253807961940765,
-0.055142395198345184,
0.0171152763068676,
-0.01947430893778801,
-0.030765721574425697,
0.0038764318451285362,
-0.02513844519853592,
-0.0021931633818894625,
-0.004288034047931433,
0.037081051617860794,
0.018073633313179016,
0.006966519169509411,
-0.013466146774590015,
0.06831366568803787,
0.03101145476102829,
-0.013797885738313198,
-0.030225111171603203,
-0.019744614139199257,
-0.03919434919953346,
0.022681118920445442,
-0.055437274277210236,
-0.01008118037134409,
-0.03246127814054489,
-0.003735135542228818,
-0.040251001715660095,
0.029881084337830544,
-0.005645706783980131,
0.006831366568803787,
-0.013613586314022541,
-0.002289920812472701,
0.020739831030368805,
0.016193779185414314,
-0.013994472101330757,
-0.0014828427229076624,
-0.0033112468663603067,
0.007605424150824547,
-0.03531177341938019,
0.005790074355900288,
-0.005578130017966032,
0.03577866777777672,
0.02290227822959423,
-0.003990083001554012,
-0.009362412616610527,
0.010382202453911304,
-0.01882311701774597,
-0.0051726712845265865,
-0.012986968271434307,
0.013404713943600655,
-0.034156832844018936,
-0.004401685204356909,
-0.012790381908416748,
-0.00531703932210803,
0.030077669769525528,
-0.03037255071103573,
0.015763746574521065,
0.0009222651715390384,
-0.010677081532776356,
-0.03332133963704109,
0.0333704873919487,
-0.013920752331614494,
-0.006548773963004351,
-0.013675019145011902,
0.044281017035245895,
0.004254245664924383,
0.03440256416797638,
0.007636140566319227,
-0.007691430393606424,
-0.003431041492149234,
0.04010356217622757,
-0.001426784903742373,
0.009657291695475578,
-0.015001974999904633,
0.0655614584684372,
0.03292816877365112,
0.0084900613874197,
-0.020604679360985756,
-0.007918733172118664,
0.006425907369703054,
0.025924788787961006,
0.009337838739156723,
-0.004364825319498777,
0.009847734123468399,
0.010996533557772636,
0.015173988416790962,
-0.0005290930275805295,
-0.0189951304346323,
-0.013761025853455067,
0.0287752877920866,
0.008754223585128784,
0.0385308712720871,
0.012716662138700485,
0.02911931276321411,
-0.01164158247411251,
0.0011388170532882214,
-0.00952213816344738,
-0.020580105483531952,
0.009325552731752396,
-0.004877792205661535,
-0.022705692797899246,
0.028406688943505287,
-0.028726141899824142,
0.03855544701218605,
-0.009792444296181202,
0.044969066977500916,
0.013994472101330757,
0.06664267927408218,
-0.00024400479742325842,
0.0017354865558445454,
0.026047656312584877,
-0.03199438378214836,
-0.04206942021846771,
0.0342305526137352,
-0.025875642895698547,
0.03295274078845978,
-0.02548247016966343,
-0.007543990854173899,
-0.005780859384685755,
0.012741235084831715,
-0.030519990250468254,
0.006536487489938736,
0.021563036367297173,
0.03037255071103573,
-0.0044907634146511555,
-0.05401202663779259,
0.04275747388601303,
0.016537804156541824,
-0.019117996096611023,
-0.012452499940991402,
0.008649787865579128,
0.02049409970641136,
0.038580019026994705,
0.022287948057055473,
-0.02727631852030754,
-0.0078081535175442696,
0.0004403989005368203,
-0.0015757603105157614,
0.027202598750591278,
-0.0256053376942873,
0.01490368228405714,
-0.013564439490437508,
0.03548378869891167,
-0.00719382194802165,
-0.025163019075989723,
-0.002058010548353195,
0.03914520516991615,
0.046984072774648666,
0.02247224748134613,
-0.001586511149071157,
0.005845364183187485,
0.0054276189766824245,
-0.03462372347712517,
-0.03275615721940994,
-0.030470842495560646,
0.015124841593205929,
0.031109748408198357,
-0.040300145745277405,
-0.017569880932569504,
0.03432884439826012,
0.005525912158191204,
-0.03671245276927948,
-0.0019658608362078667,
0.06860854476690292,
-0.009982886724174023,
0.05297994986176491,
-0.04074246436357498,
0.020346660166978836,
-0.016500944271683693,
-0.0005943657597526908,
0.017766466364264488,
0.008981526829302311,
-0.04066874459385872,
-0.024855852127075195,
-0.040644172579050064,
-0.03499232232570648,
0.020874984562397003,
0.0011941068805754185,
-0.020383520051836967,
0.0034279697574675083,
0.04914652183651924,
0.005283250939100981,
-0.0002317181642865762,
0.00926411896944046,
-0.008588354103267193,
0.025851069018244743,
0.039218924939632416,
0.00631532771512866,
-0.00641362089663744,
0.025126159191131592,
-0.003590767737478018,
-0.035238053649663925,
-0.006843653041869402,
-0.0024634692817926407,
0.03774452954530716,
0.019363729283213615,
0.005968230776488781,
-0.011672298423945904,
-0.030298830941319466,
0.0005406117415986955,
0.04285576567053795,
-0.004079161211848259,
0.012341920286417007,
-0.0050467331893742085,
-0.0024788277223706245,
-0.014363070949912071,
0.014019045047461987,
0.02200535498559475,
0.043175216764211655,
0.004318750463426113,
0.015210848301649094,
0.023909782990813255,
0.03666330501437187,
-0.01250164583325386,
0.009921453893184662,
0.02835754305124283,
-0.006266181357204914,
-0.01076308824121952,
-0.00008787820115685463,
0.021513888612389565,
-0.002762956079095602,
-0.009534425102174282,
-0.00877265352755785,
0.03083944134414196,
0.032534997910261154,
-0.015640880912542343,
-0.004773356020450592,
0.006898942869156599,
0.01882311701774597,
-0.01849137805402279,
0.024253807961940765,
0.02316029742360115,
-0.03474659100174904,
0.005817719269543886,
0.0016202992992475629,
0.009288692846894264,
-0.01612005941569805,
0.027816930785775185,
-0.011991751380264759,
0.009737154468894005,
-0.010204046033322811,
0.002363640582188964,
0.012034754268825054,
-0.011205406859517097,
-0.021329589188098907,
0.015640880912542343,
-0.001988898264244199,
0.02440124750137329,
-0.010253192856907845,
-0.0008477774681523442,
-0.008072315715253353,
-0.009227259084582329,
0.012255913577973843,
-0.005227961111813784,
0.004546053241938353,
-0.0008677432779222727,
-0.03479573503136635,
-0.010591074824333191,
-0.016353504732251167,
-0.012133046984672546,
-0.030225111171603203,
-0.028849007561802864,
0.01952345483005047,
-0.002594014862552285,
-0.04307692497968674,
0.007845013402402401,
-0.0010028962278738618,
-0.007740577217191458,
0.011242266744375229,
0.023184871301054955,
0.010056606493890285,
0.010025890544056892,
-0.01202861126512289,
-0.0016402651090174913,
0.013625873252749443,
0.01334328018128872,
-0.016586950048804283,
-0.015923472121357918,
-0.029905658215284348,
-0.007654570508748293,
-0.02445039339363575,
-0.012986968271434307,
0.006146386731415987,
0.01663609780371189,
0.009257975965738297,
0.005694853141903877,
0.01792619377374649,
-0.01788933388888836,
0.009024529717862606,
0.034672871232032776,
-0.013969898223876953,
-0.005694853141903877,
0.002266883384436369,
0.0117951650172472,
0.002051867311820388,
0.0015634737210348248,
0.004346395377069712,
-0.009098249487578869,
0.039096057415008545,
-0.0014290886465460062,
-0.01117468997836113,
-0.009165826253592968,
-0.023836063221096992,
-0.014105051755905151,
0.05386458709836006,
-0.021071569994091988,
-0.024339813739061356,
0.037081051617860794,
-0.0032037387136369944,
-0.006579490378499031,
0.0143876438960433,
0.01081223413348198,
0.00024784437846392393,
0.022238800302147865,
-0.025973936542868614,
0.02174733579158783,
0.006063451990485191,
-0.022619687020778656,
0.0047979289665818214,
0.012575365602970123,
-0.0261705219745636,
-0.006339901126921177,
-0.003166878828778863,
-0.022877706214785576,
0.022459959611296654,
0.019965773448348045,
0.00022288714535534382,
-0.012268200516700745,
0.009872307069599628,
0.004991443362087011,
0.04079161211848259,
-0.0117951650172472,
-0.020432665944099426,
0.022484533488750458,
0.011672298423945904,
-0.01978147402405739,
-0.021636756137013435,
-0.024757560342550278,
0.003381894901394844,
-0.024548687040805817,
-0.029782790690660477,
-0.015407434664666653,
-0.008201325312256813,
-0.01780332624912262,
0.008275045081973076,
0.009417702443897724,
0.00845320150256157,
0.0031607355922460556,
-0.02329545095562935,
-0.006585633847862482,
0.005756286438554525,
0.008158322423696518,
-0.00016250988119281828,
-0.013773312792181969,
-0.029487911611795425,
-0.010566501878201962,
0.021120717748999596,
-0.00201039994135499,
0.008293475024402142,
0.019204003736376762,
0.017361007630825043,
0.01723814196884632,
-0.004582913126796484,
0.026711134240031242,
-0.015173988416790962,
-0.0015680812066420913,
-0.04983457177877426,
0.020666111260652542,
-0.013503006659448147,
-0.019437449052929878,
0.01181973796337843,
-0.006911229342222214,
-0.0420202761888504,
0.00011547512258403003,
-0.002395892981439829,
0.013908465392887592,
0.001506648026406765,
-0.0008907807059586048,
-0.017447015270590782,
0.022619687020778656,
0.003940936643630266,
-0.0051020230166614056,
-0.017385581508278847,
0.015309141017496586,
-0.014829962514340878,
0.012065471149981022,
0.015382860787212849,
-0.024130942299962044,
-0.02329545095562935,
0.02328316494822502,
-0.006140243262052536,
0.02226337417960167,
-0.022939138114452362,
0.021993067115545273,
0.015026548877358437,
-0.026907719671726227,
0.03590153157711029,
0.025851069018244743,
0.018540525808930397,
-0.017225855961441994,
-0.02997937798500061,
-0.005710211582481861,
0.03398481756448746,
0.007470271084457636,
0.00411602109670639,
0.015518014319241047,
-0.05528983473777771,
0.0019336084369570017,
-0.019670894369482994,
-0.006456624250859022,
-0.044797055423259735,
0.010191760025918484,
0.019695468246936798,
0.033911097794771194,
-0.03700733184814453,
-0.003391109872609377,
-0.004496906418353319,
-0.006769933272153139,
0.02123129740357399,
-0.008520778268575668,
-0.013011541217565536,
-0.014006758108735085,
-0.02062925137579441,
0.01192417461425066,
0.02153846248984337,
-0.010185616090893745,
0.013527579605579376,
0.010154900141060352,
0.005022160243242979,
-0.021563036367297173,
0.027300892397761345,
-0.005826934240758419,
0.018982844427227974,
0.018945984542369843,
-0.013625873252749443,
0.02548247016966343,
0.00039106039912439883,
-0.021071569994091988,
0.02538417838513851,
0.026514548808336258,
-0.000408530468121171,
-0.025150731205940247,
0.014535083435475826,
0.03172408044338226,
-0.014338497072458267,
0.0062385364435613155,
-0.011358989402651787,
-0.002563298214226961,
0.014768529683351517,
0.005498266778886318,
-0.0029948661103844643,
-0.018417658284306526,
0.022029927000403404,
-0.009933740831911564,
-0.00007861523772589862,
-0.016500944271683693,
0.0065426304936409,
-0.01306068804115057,
-0.0016018693568184972,
0.005403045564889908,
-0.023148011416196823,
-0.03695818409323692,
0.01715213619172573,
0.012876388616859913,
-0.01900741644203663,
-0.0024911141954362392,
-0.013220414519309998,
-0.0009683400276117027,
0.0546509325504303,
-0.04103734344244003,
0.002033437369391322,
0.02483128011226654,
0.004939225502312183,
0.006511914078146219,
-0.00036610319511964917,
0.037769101560115814,
0.003277458716183901,
-0.020064067095518112,
-0.0028888939414173365,
-0.019793761894106865,
0.020100926980376244,
0.03747422248125076,
-0.022423099726438522,
-0.0002121363504556939,
0.039784107357263565,
-0.01766817457973957,
-0.014019045047461987,
-0.018601957708597183,
-0.01355215348303318,
0.03698275610804558,
-0.003341963514685631,
-0.0024880426935851574,
-0.009128966368734837,
0.00690508633852005,
-0.02624424174427986,
0.0024557902943342924,
0.01668524369597435,
0.011875027790665627,
0.004496906418353319,
0.016500944271683693,
0.032829876989126205,
-0.0038149987813085318,
-0.019326869398355484,
0.021722761914134026,
0.04192198067903519,
-0.010032033547759056,
0.027423758059740067,
0.007077098824083805,
-0.03413225710391998,
-0.030126817524433136,
0.0034033965785056353,
-0.0009691079612821341,
-0.01646408438682556,
0.001092742197215557,
0.01716442219913006,
0.01363815926015377,
0.016697529703378677,
0.012520075775682926,
-0.006011233665049076,
0.004579841624945402,
-0.047672126442193985,
-0.032584141939878464,
-0.03602439910173416,
0.009300978854298592,
0.0059252274222671986,
-0.007414981257170439,
-0.00443854508921504,
0.019191715866327286,
-0.016316644847393036,
0.05194787308573723,
0.011008820496499538,
-0.0215753223747015,
-0.012986968271434307,
-0.00019034677825402468,
-0.03624555841088295,
0.02362718991935253,
-0.004456975031644106,
0.008238185197114944,
-0.020260652527213097,
-0.024241521954536438,
-0.025875642895698547,
-0.03894861787557602,
0.0028735357336699963,
-0.018687965348362923,
-0.036220986396074295,
-0.01874939724802971,
-0.01801219955086708,
-0.03174865245819092,
0.028676994144916534,
0.02045723982155323,
0.005338540766388178,
-0.0036429858300834894,
-0.0034341132268309593,
-0.00894466694444418,
0.0005352363223209977,
0.030298830941319466,
0.007980166003108025,
0.005151169840246439,
-0.009227259084582329,
-0.04071789234876633,
0.010898240841925144,
-0.034672871232032776,
-0.021501602604985237,
-0.012778094969689846,
-0.05317653715610504,
0.015407434664666653,
-0.005845364183187485,
0.0004615165526047349,
-0.000853152887430042,
0.02479442022740841,
-0.0379902608692646,
0.0045675546862185,
0.010044320486485958,
0.022373953834176064,
0.02329545095562935,
0.03479573503136635,
-0.009208829142153263,
0.0017769539263099432,
0.03106060065329075,
0.03695818409323692,
-0.010935100726783276,
0.0005905261496081948,
0.03663873299956322,
-0.015898900106549263,
-0.018540525808930397,
0.00887709017843008,
0.041283078491687775,
-0.010824521072208881,
-0.014485936611890793,
0.009509852156043053,
-0.027472905814647675,
0.02727631852030754,
-0.03902233764529228,
-0.0016540875658392906,
-0.005098951514810324,
0.02252139337360859,
0.023995788767933846,
0.002377463039010763,
-0.00434332387521863,
0.014571943320333958,
-0.00641362089663744,
-0.022029927000403404,
-0.0005682566552422941,
-0.012851814739406109,
-0.00514809787273407,
0.02209136076271534,
0.008913950063288212,
-0.00047034755698405206,
0.025335030630230904,
0.003646057564765215,
0.022115934640169144,
0.02531045861542225,
-0.00900609977543354,
0.0006423603626899421,
0.0033603934571146965,
0.015923472121357918,
0.0069358027540147305,
0.03366536647081375,
-0.0030301902443170547,
-0.006868226453661919,
0.014473650604486465,
0.03821142017841339,
-0.02929132618010044,
-0.017447015270590782,
-0.02152617648243904,
0.020260652527213097,
-0.023430604487657547,
0.008219755254685879,
0.10104524344205856,
-0.027644917368888855,
0.01647637039422989,
0.009915310889482498,
0.004487691447138786,
-0.015382860787212849,
-0.006131028290838003,
-0.02316029742360115,
-0.02565448358654976,
-0.044453028589487076,
0.02024836651980877,
0.01668524369597435,
0.02187020145356655,
0.009221116080880165,
0.008434771560132504,
-0.01647637039422989,
0.0015726886922493577,
0.014301637187600136,
0.006634780205786228,
-0.001198714366182685,
0.007476414553821087,
0.005467550363391638,
-0.01801219955086708,
0.052390191704034805,
-0.02071525901556015,
-0.018257932737469673,
-0.021477028727531433,
-0.019756902009248734,
-0.023098865523934364,
0.002249989192932844,
0.01908113621175289,
0.035532932728528976,
0.019105710089206696,
-0.01978147402405739,
0.017643600702285767,
-0.02110842987895012,
-0.018110493198037148,
-0.004232744220644236,
-0.01990434154868126,
-0.007494844496250153,
0.022251088172197342,
0.0223002340644598,
0.013195840641856194,
0.01887226477265358,
0.0399806946516037,
-0.003999297972768545,
-0.04730352759361267,
0.006005090661346912,
0.025801923125982285,
-0.03835885971784592,
0.013527579605579376,
-0.003277458716183901,
0.029217606410384178,
0.0012086972128599882,
-0.018085919320583344,
-0.03400939330458641,
0.017987625673413277,
-0.0031945237424224615,
0.010572644881904125,
-0.03914520516991615,
-0.011487998999655247,
0.005777787882834673,
-0.003940936643630266,
0.003839571960270405,
0.03071657568216324
] | 2025-01-04 | 1 | 39752754 | [
"T cell function",
"CAR-T cell manufacturing efficiency",
"antitumor efficacy",
"CAR-T cell yield",
"human CAR-T cells",
"b",
"superior efficacy",
"anti-CD19 CAR-T cells",
"continuous NX-1607 treatment",
"CAR-T cell production",
"NX-1607",
"cytokine production",
"NX-1607-treated CAR-T cells",
"cytokine secretion",
"immunosuppressive signals",
"manufacturing",
"cancer immunotherapy",
"Cbl-b enhances",
"Casitas B-cell",
"cytotoxic activity",
"Chimeric antigen receptor T (CAR-T) cells",
"Cbl-b",
"The Cbl-b inhibitor NX-1607",
"expansion",
"clinical applications",
"hematological malignancies",
"Treatment",
"function",
"the manufacturing phase",
"the antitumor activity"
] | [
"CAR-T cells",
"Cancer immunotherapy",
"Cbl-b",
"NX-1607"
] | 0 | 10.1016/j.intimp.2024.113971 | [
"Wang",
"Li",
"Feng",
"Ma",
"Li",
"Zhao",
"Wu",
"Shi",
"Zong",
"Li",
"Cong",
"Wang"
] | [
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China.",
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China.",
"Department of Hematology, Anhui Provincial Cancer Hospital, Hefei, China.",
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China.",
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China.",
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China.",
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China.",
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China.",
"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.",
"School of Life Sciences, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address: [email protected].",
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address: [email protected].",
"School of Pharmacy, Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, China; Institute of Clinical Immunology, Anhui Medical University, Hefei, Anhui 230032, China. Electronic address: [email protected]."
] | [
"39752754"
] | [] | 7.52892 | 5.303981 |
39751840 | 82 | CCR5 and IL-12 co-expression in CAR T cells improves antitumor efficacy by reprogramming tumor microenvironment in solid tumors. | Chimeric antigen receptor (CAR) T cell therapy for solid tumors faces significant challenges, including inadequate infiltration, limited proliferation, diminished effector function of CAR T cells, and an immunosuppressive tumor microenvironment (TME). In this study, we utilized The Cancer Genome Atlas database to identify key chemokines (CCL4, CCL5, and CCR5) associated with T cell infiltration across various solid tumor types. The CCL4/CCL5-CCR5 axis emerged as significantly correlated with the presence of T cells within tumors, and enhancing the expression of CCR5 in CAR T cells bolstered their migratory capacity. Furthermore, single-cell immunoprofiling of tumor tissues revealed that macrophages within the TME primarily interact with CD8 | [
0.017982536926865578,
0.0088077737018466,
0.03513934463262558,
0.07592117041349411,
-0.02107902057468891,
-0.011531531810760498,
0.03683667629957199,
0.0001901254872791469,
-0.025735212489962578,
-0.008756165392696857,
-0.026721499860286713,
-0.01568884588778019,
-0.009031408466398716,
0.007334076799452305,
0.018934419378638268,
-0.043648939579725266,
0.0540393590927124,
0.006628767121583223,
0.027799535542726517,
0.0403001494705677,
0.02334977500140667,
0.0036928425543010235,
-0.0030620775651186705,
-0.0018593232380226254,
-0.054268728941679,
-0.01620492711663246,
0.002259285654872656,
0.005860380362719297,
-0.014186479151248932,
-0.004991644993424416,
0.026285698637366295,
-0.021273983642458916,
-0.03525403141975403,
-0.02511591650545597,
-0.035735707730054855,
0.009467209689319134,
0.010424825362861156,
0.02223733440041542,
-0.018188970163464546,
-0.030620774254202843,
0.03105657547712326,
0.04511690139770508,
0.04245622083544731,
0.08440782874822617,
-0.053488872945308685,
-0.04435998573899269,
-0.027707787230610847,
-0.07839836180210114,
0.019863363355398178,
0.014599342830479145,
-0.03646968677639961,
-0.004469830542802811,
0.0011984535958617926,
0.023384179919958115,
-0.0629388839006424,
0.02107902057468891,
-0.024542493745684624,
-0.004257664084434509,
0.015356261283159256,
0.01928994059562683,
0.021858874708414078,
-0.023131873458623886,
0.01643429696559906,
-0.02885463275015354,
-0.04328195005655289,
-0.028327083215117455,
-0.049681346863508224,
-0.055415574461221695,
0.016984781250357628,
-0.00027560131275095046,
-0.019094977527856827,
-0.021835938096046448,
-0.004736471921205521,
0.01165194995701313,
0.05252552404999733,
-0.02070056088268757,
-0.0039852880872786045,
0.019416093826293945,
-0.037478912621736526,
-0.029955605044960976,
0.033809006214141846,
-0.002352466806769371,
0.010906500741839409,
-0.07982044667005539,
-0.016961844637989998,
-0.015941152349114418,
0.006445271894335747,
-0.04236447438597679,
-0.05197503790259361,
-0.01770729385316372,
-0.0018177501624450088,
0.020666155964136124,
-0.026538005098700523,
0.028579389676451683,
0.005969330668449402,
0.006221636664122343,
-0.009054345078766346,
-0.07344398647546768,
0.0316988080739975,
0.023739701136946678,
0.02933630719780922,
0.005671150982379913,
-0.03929092735052109,
-0.009730984456837177,
0.04449760541319847,
0.00685240188613534,
-0.059131354093551636,
-0.029703298583626747,
0.010069303214550018,
-0.0024499488063156605,
0.08078379929065704,
0.0027538628783077,
-0.023854386061429977,
0.045621514320373535,
-0.01364746131002903,
-0.04300670698285103,
-0.01784491539001465,
-0.022822225466370583,
-0.03282271698117256,
0.025620529428124428,
-0.02938218228518963,
0.05605780705809593,
0.02063175104558468,
-0.03929092735052109,
0.010000492446124554,
-0.020000984892249107,
0.10927143692970276,
-0.028739947825670242,
-0.06018645316362381,
-0.02246670424938202,
-0.002134566195309162,
-0.03087308071553707,
0.019106445834040642,
0.008744697086513042,
-0.04025427624583244,
-0.0033831943292170763,
-0.0041372450068593025,
0.022065307945013046,
-0.012236841954290867,
-0.019828958436846733,
-0.0075691803358495235,
0.0034778090193867683,
0.019106445834040642,
-0.013498371466994286,
-0.030207909643650055,
-0.05408523231744766,
-0.021319858729839325,
0.041561681777238846,
0.007024428807199001,
0.014610812067985535,
-0.014071794226765633,
0.05211266130208969,
0.05972771346569061,
0.004051231779158115,
0.0034175997134298086,
-0.04880974441766739,
0.005329964682459831,
0.055232077836990356,
-0.019129382446408272,
-0.05844324827194214,
-0.015390666201710701,
-0.030551964417099953,
-0.018762392923235893,
-0.013234596699476242,
0.03335026651620865,
0.00395661685615778,
-0.024725988507270813,
0.03683667629957199,
-0.0622507743537426,
-0.004054098855704069,
-0.033923689275979996,
-0.062021404504776,
-0.06280125677585602,
-0.019094977527856827,
-0.06743451207876205,
0.0004730737709905952,
0.018234843388199806,
0.04449760541319847,
-0.01854449138045311,
-0.0036641713231801987,
0.008916723541915417,
0.05592018738389015,
0.06266363710165024,
-0.0018578896997496486,
-0.02135426364839077,
0.03162999823689461,
0.010774613358080387,
0.05697528272867203,
-0.023154810070991516,
-0.02255845069885254,
0.01782197877764702,
-0.003575290786102414,
0.05078231915831566,
0.015000739134848118,
-0.018555959686636925,
-0.003962351009249687,
0.015723252668976784,
0.03729541599750519,
-0.01854449138045311,
-0.019530778750777245,
0.03497878834605217,
0.00044977848301641643,
-0.043717749416828156,
0.01673247665166855,
-0.019209662452340126,
-0.027799535542726517,
-0.00971378106623888,
0.010751676745712757,
-0.013372218236327171,
0.030551964417099953,
0.03518522158265114,
-0.018888546153903008,
-0.011290693655610085,
0.001384815899655223,
-0.03488704189658165,
-0.01450759544968605,
-0.0028026036452502012,
0.035965073853731155,
0.038098208606243134,
0.04277733713388443,
-0.021973559632897377,
0.015058081597089767,
0.020643219351768494,
0.000987720675766468,
-0.02899225428700447,
0.035781580954790115,
0.018395401537418365,
-0.04291496053338051,
-0.0015095353592187166,
-0.026515068486332893,
0.010774613358080387,
0.03268509730696678,
-0.01125628873705864,
-0.023946134373545647,
-0.03894687443971634,
-0.025826960802078247,
0.01770729385316372,
0.003520815633237362,
0.04637843370437622,
-0.015746189281344414,
-0.011835445649921894,
-0.014152073301374912,
0.008566935546696186,
0.004564445000141859,
-0.006680374965071678,
0.009409867227077484,
0.002004112582653761,
-0.06945296376943588,
-0.006313384510576725,
-0.009461475536227226,
0.013785082846879959,
0.013521308079361916,
-0.01272998470813036,
0.00785589125007391,
0.01852155476808548,
0.0273637343198061,
0.05252552404999733,
-0.027684850618243217,
0.00936399307101965,
-0.04296083375811577,
0.022913973778486252,
0.0017905125860124826,
-0.04793814197182655,
-0.06197553128004074,
-0.02931337058544159,
-0.01682422310113907,
-0.03293740376830101,
-0.01584940403699875,
-0.0031566922552883625,
0.014106200076639652,
0.05408523231744766,
0.0067262486554682255,
0.03690548986196518,
-0.013980046845972538,
-0.06000295653939247,
0.02146894857287407,
-0.016067305579781532,
0.021767128258943558,
0.02121664211153984,
0.018418338149785995,
-0.036010947078466415,
0.016216395422816277,
-0.002783967414870858,
0.019909238442778587,
-0.02334977500140667,
-0.0420662946999073,
0.03738716244697571,
0.020998740568757057,
0.003970952704548836,
-0.029565677046775818,
0.0308960173279047,
0.01122188288718462,
-0.030483152717351913,
-0.0125694265589118,
-0.0671592727303505,
-0.007873094640672207,
-0.02738667093217373,
-0.04062126949429512,
-0.03325852006673813,
0.002804037183523178,
-0.04335075989365578,
0.015321856364607811,
-0.028625262901186943,
-0.0429837703704834,
0.028166525065898895,
0.039956096559762955,
-0.00043365094461478293,
-0.01886560767889023,
0.05789276212453842,
0.05454397201538086,
0.028005966916680336,
0.005688353907316923,
0.012168031185865402,
0.04268559068441391,
-0.008429314009845257,
0.03706604614853859,
0.03259335085749626,
-0.04438292235136032,
0.02922162413597107,
-0.037478912621736526,
-0.06472796201705933,
-0.024404872208833694,
-0.030643712729215622,
0.012168031185865402,
0.026583878323435783,
-0.026033392176032066,
-0.0069842892698943615,
0.015333324670791626,
-0.005037518683820963,
-0.05858086794614792,
0.032203420996665955,
-0.05647067353129387,
0.06711339950561523,
-0.003168160794302821,
0.026423320174217224,
-0.028717011213302612,
-0.024794800207018852,
-0.034038376063108444,
0.013177255168557167,
0.026790311560034752,
-0.017867853865027428,
0.012535021640360355,
-0.03463473543524742,
0.06619592010974884,
0.02318921685218811,
0.021342795342206955,
0.005413110833615065,
0.045598577708005905,
0.024244314059615135,
-0.005524928215891123,
0.017718762159347534,
0.017649952322244644,
0.03564395755529404,
0.026675626635551453,
-0.007345545571297407,
0.03633206710219383,
-0.045575641095638275,
-0.010166785679757595,
0.0312400721013546,
0.017741700634360313,
0.0254829078912735,
0.0006461757584474981,
-0.006846667733043432,
0.009226372465491295,
0.07188427448272705,
0.03160706162452698,
-0.04635549336671829,
0.015814999118447304,
-0.02720317617058754,
-0.04036896303296089,
-0.02500123158097267,
-0.0038447994738817215,
0.039726726710796356,
-0.03571276739239693,
-0.015287450514733791,
0.04426823556423187,
-0.010292937979102135,
0.055323828011751175,
0.029726235195994377,
0.002191908424720168,
0.038235828280448914,
-0.028051840141415596,
0.0042289928533136845,
-0.022478172555565834,
0.005378705449402332,
0.004681996535509825,
0.006990023422986269,
-0.023739701136946678,
-0.07142553478479385,
0.03348788991570473,
0.005992267746478319,
-0.0034692075569182634,
0.026056330651044846,
0.017558204010128975,
0.00014398286293726414,
0.05665416643023491,
0.0016973313177004457,
0.049681346863508224,
0.0392221175134182,
0.019530778750777245,
0.016193458810448647,
-0.05628717690706253,
-0.0010464965598657727,
-0.026538005098700523,
0.031721748411655426,
-0.009954619221389294,
0.017110934481024742,
-0.01248914748430252,
0.006101218052208424,
-0.029863856732845306,
0.02931337058544159,
-0.009346790611743927,
0.007815752178430557,
0.03094189241528511,
-0.028143588453531265,
-0.011737964116036892,
-0.04608025401830673,
0.03307502344250679,
-0.005481921602040529,
0.05858086794614792,
0.02906106412410736,
0.011892788112163544,
0.027799535542726517,
-0.012340057641267776,
0.009232106618583202,
0.0026119407266378403,
0.0505070760846138,
0.017087997868657112,
0.008417845703661442,
-0.03142356500029564,
-0.010321609675884247,
0.04027721285820007,
-0.006817996501922607,
-0.010292937979102135,
-0.013911236077547073,
0.022902505472302437,
-0.02885463275015354,
0.012385931797325611,
-0.03371725603938103,
0.015895279124379158,
-0.057021159678697586,
-0.005510592833161354,
0.014369973912835121,
-0.016009964048862457,
0.05624130368232727,
0.007070302497595549,
0.03114832378923893,
-0.018418338149785995,
-0.030299657955765724,
-0.00972525030374527,
-0.05770926550030708,
-0.029634486883878708,
-0.0145649379119277,
0.013349281623959541,
-0.008710291236639023,
-0.012947885319590569,
0.02153775840997696,
-0.04211216792464256,
0.018016943708062172,
-0.0030821473337709904,
0.04995658993721008,
-0.04513983801007271,
-0.008933926932513714,
-0.021044615656137466,
-0.023292431607842445,
0.018877077847719193,
0.03470354527235031,
-0.030070289969444275,
0.06073693931102753,
-0.03440536558628082,
0.032226357609033585,
-0.0073398114182055,
-0.013360749930143356,
0.02718023769557476,
0.0009490146767348051,
0.014324100688099861,
0.018877077847719193,
-0.009169030003249645,
0.035460464656353,
-0.00208009104244411,
0.008641480468213558,
0.004702066536992788,
-0.057250525802373886,
0.007047365419566631,
0.009186232462525368,
0.045896757394075394,
-0.03885512426495552,
0.011726494878530502,
0.0008916723891161382,
0.04534627124667168,
-0.01114160381257534,
-0.0003189663984812796,
0.01680128648877144,
-0.009966087527573109,
-0.0008701690239831805,
-0.008744697086513042,
-0.0033000479452311993,
0.0011733663268387318,
-0.013693335466086864,
0.004208922851830721,
-0.020322103053331375,
0.013739208690822124,
0.02230614423751831,
0.009880074299871922,
0.026721499860286713,
0.037478912621736526,
0.012408868409693241,
0.059498343616724014,
0.0006246723933145404,
0.03860281780362129,
-0.004249062389135361,
-0.008767633698880672,
0.026193952187895775,
0.003150958102196455,
-0.011210414581000805,
-0.015631504356861115,
-0.04410767927765846,
-0.0076609281823039055,
-0.015321856364607811,
-0.012752922251820564,
-0.018326591700315475,
-0.012190967798233032,
0.006554222200065851,
0.008245819248259068,
0.009943150915205479,
-0.014140604995191097,
-0.009083016775548458,
-0.05770926550030708,
-0.01886560767889023,
-0.04445173218846321,
0.030322594568133354,
-0.03247866407036781,
0.0037329820916056633,
0.0067262486554682255,
0.001637122011743486,
-0.010705802589654922,
-0.04309845343232155,
0.018693581223487854,
0.0033143835607916117,
-0.018991760909557343,
0.010717270895838737,
-0.012328589335083961,
0.00885364692658186,
-0.011227617040276527,
0.009960353374481201,
0.0422956608235836,
-0.007104707881808281,
-0.019060572609305382,
0.03566689416766167,
-0.029955605044960976,
0.019737211987376213,
-0.035919200628995895,
0.01822337508201599,
0.00457304622977972,
0.024886546656489372,
-0.012443273328244686,
-0.013819488696753979,
-0.010298673063516617,
0.00961056537926197,
-0.014129136689007282,
-0.03497878834605217,
0.008951129391789436,
0.025918709114193916,
-0.018968824297189713,
-0.013291939161717892,
0.03507053479552269,
-0.0022435165010392666,
0.0006221637013368309,
-0.014496127143502235,
0.028005966916680336,
0.031790558248758316,
-0.008308895863592625,
-0.0017001985106617212,
-0.005889051593840122,
0.03355669975280762,
-0.0010945206740871072,
-0.014840180985629559,
0.004343677312135696,
0.012661173939704895,
0.0034749419428408146,
-0.04220391437411308,
0.019037635996937752,
0.010952374897897243,
0.039566170424222946,
0.027524292469024658,
-0.0024227111134678125,
-0.024886546656489372,
-0.012007472105324268,
-0.005714157596230507,
-0.039497360587120056,
0.03126300871372223,
0.0018134494312107563,
0.04422236233949661,
-0.00024262949591502547,
-0.014186479151248932,
0.019794553518295288,
-0.009300917387008667,
-0.023177746683359146,
-0.02523060142993927,
0.010459231212735176,
0.019484905526041985,
0.013498371466994286,
-0.014358505606651306,
-0.04039189964532852,
-0.01453053206205368,
0.03536871448159218,
-0.0023280964232981205,
-0.010464965365827084,
-0.00034118653275072575,
0.014083262532949448,
0.03557514771819115,
0.02015007473528385,
-0.028464704751968384,
-0.026698563247919083,
0.03890100121498108,
-0.013337813317775726,
-0.018108690157532692,
-0.028671137988567352,
-0.006651703733950853,
-0.047295909374952316,
-0.02065468765795231,
0.026560941711068153,
-0.022879566997289658,
-0.01071153674274683,
-0.009335322305560112,
-0.018154563382267952,
-0.006886807270348072,
0.010172519832849503,
-0.0014794307062402368,
0.0214918851852417,
-0.0014980669366195798,
-0.023040127009153366,
-0.0010493636364117265,
0.029795046895742416,
-0.003064944641664624,
-0.03516228497028351,
-0.0028169392608106136,
-0.011594608426094055,
-0.01942756213247776,
0.012282715179026127,
0.025964582338929176,
0.026629753410816193,
-0.028258273378014565,
-0.016629260033369064,
0.010252798907458782,
0.013521308079361916,
-0.00626177666708827,
0.002342432038858533,
0.0043924180790781975,
0.0011081395205110312,
0.012913480401039124,
-0.04066714271903038,
-0.028510579839348793,
-0.024221377447247505,
0.01023559644818306,
-0.0015038012061268091,
0.02518472634255886,
-0.000013316399417817593,
0.04341956973075867,
0.06215902790427208,
-0.011462721042335033,
0.008349034935235977,
0.0006314818165265024,
-0.006491145584732294,
-0.05087406560778618,
-0.0005296992603689432,
-0.008154071867465973,
0.0007225126610137522,
0.014060325920581818,
0.018991760909557343,
0.06917772442102432,
0.032019928097724915,
0.030024414882063866,
-0.01677834987640381,
-0.010952374897897243,
0.03871750459074974,
0.0157347209751606,
0.008503859862685204,
-0.025735212489962578,
-0.007293937262147665,
0.0026936533395200968,
0.02117076888680458,
-0.025781087577342987,
-0.0352310948073864,
0.0038419323973357677,
0.0038906733971089125,
0.010384686291217804,
-0.01458787452429533,
0.01553975697606802,
-0.024748925119638443,
0.001713100471533835,
-0.021916218101978302,
-0.020838182419538498,
-0.001297369017265737,
-0.007586382795125246,
0.0253682229667902,
-0.007873094640672207,
-0.0028169392608106136,
-0.009983289986848831,
0.022661667317152023,
0.02130838856101036,
0.004530039615929127,
0.004676262382417917,
-0.037570659071207047,
0.015264513902366161,
-0.0188426710665226,
-0.015390666201710701,
-0.013498371466994286,
0.02307453192770481,
0.04282321035861969,
-0.0047909473069012165,
0.005071924068033695,
-0.026813248172402382,
0.008997002616524696,
-0.0010615488281473517,
0.024817736819386482,
-0.011531531810760498,
0.04133231192827225,
-0.00312228687107563,
0.020230354741215706,
-0.002842743182554841,
-0.010453497059643269,
-0.005797304213047028,
0.005576536059379578,
0.047571152448654175,
0.017627015709877014,
-0.03637794032692909,
0.030345531180500984,
-0.02878582291305065,
-0.002220579655840993,
-0.01840686984360218,
-0.015092486515641212,
-0.0403001494705677,
0.0025345284957438707,
-0.009381196461617947,
0.02527647465467453,
-0.02917574904859066,
-0.011451252736151218,
-0.016090242192149162,
-0.007861626334488392,
0.02938218228518963,
-0.03337320312857628,
-0.0008300294284708798,
0.0018148829694837332,
-0.03160706162452698,
0.02500123158097267,
0.013716272078454494,
-0.011617545038461685,
-0.006955618038773537,
-0.013578650541603565,
0.0047651431523263454,
0.007127644959837198,
0.004495634231716394,
0.009088750928640366,
0.010413357056677341,
-0.011996003799140453,
-0.003047741949558258,
-0.015516819432377815,
0.006531285122036934,
-0.023900261148810387,
-0.01133656781166792,
0.018980292603373528,
0.007678130641579628,
-0.017099466174840927,
0.0006816562963649631,
0.04018546640872955,
0.02051706612110138,
0.007597851566970348,
0.005674018058925867,
0.024794800207018852,
-0.02745548076927662,
-0.019416093826293945,
0.029886793345212936,
-0.03435949236154556,
-0.009060079231858253,
0.013096976093947887,
-0.023177746683359146,
0.007729738485068083,
-0.030070289969444275,
0.015367729589343071,
-0.0033172506373375654,
-0.003489277558401227,
-0.010963843204081059,
-0.009415601380169392,
-0.011669153347611427,
0.0013611622853204608,
0.02511591650545597,
0.028602326288819313,
-0.011353770270943642,
-0.007397153414785862,
-0.023808512836694717,
0.0032541740220040083,
-0.03080427087843418,
0.022111181169748306,
-0.020046859979629517,
0.044038865715265274,
0.046034377068281174,
-0.07945345342159271,
-0.01715680956840515,
0.01058538444340229,
0.0029144210275262594,
-0.00026413286104798317,
0.0029115539509803057,
-0.018533023074269295,
0.002021315274760127,
0.008916723541915417,
0.002004112582653761,
-0.003884939244017005,
-0.014197947457432747,
0.021113425493240356,
-0.015929684042930603,
-0.019909238442778587,
-0.01440437976270914,
-0.0234873965382576,
-0.03741009905934334,
-0.011594608426094055,
0.04913086071610451,
-0.0057715000584721565,
0.02307453192770481,
-0.002964595565572381,
0.07858185470104218,
0.017168277874588966,
0.0220309030264616,
-0.03360257297754288,
-0.005318495910614729,
-0.039612043648958206,
-0.022225866094231606,
-0.006835199426859617,
0.01166341919451952,
0.0029316237196326256,
0.04101119562983513,
-0.025941645726561546,
-0.03697429969906807,
0.031767621636390686,
-0.023361243307590485,
-0.0369972363114357,
-0.005857513286173344,
0.011267757043242455,
0.006577158812433481,
0.02248964086174965,
0.036079760640859604,
-0.0057227592915296555,
-0.005817373748868704,
-0.03864869475364685,
0.014106200076639652,
-0.02559759095311165,
-0.030070289969444275,
0.025918709114193916,
-0.026492131873965263,
-0.021618038415908813,
-0.00918049830943346,
0.0086930887773633,
-0.009891542606055737,
-0.011244820430874825,
0.016652196645736694,
0.019622527062892914,
-0.0008307461976073682,
-0.023475928232073784,
0.03642381355166435,
0.03651556000113487,
-0.0059234569780528545,
0.00030821471591480076,
-0.007689598947763443,
-0.024313123896718025,
0.037777092307806015,
-0.045873820781707764,
0.016675133258104324,
-0.0110154515132308,
0.004105706699192524,
-0.026721499860286713,
0.041882798075675964,
-0.013395155780017376,
0.005086259916424751,
-0.015081018209457397,
-0.006909744348376989,
-0.02543703280389309,
0.018934419378638268,
-0.026331571862101555,
-0.002332397038117051,
0.013291939161717892,
0.03142356500029564,
-0.04284614697098732,
-0.005103462375700474,
-0.03149237856268883,
-0.011858382262289524,
-0.003368858713656664,
-0.003678506938740611,
0.021767128258943558,
-0.009128890000283718,
-0.0021230976562947035,
-0.0038046599365770817,
0.010929437354207039,
-0.016537511721253395,
-0.018441274762153625,
0.007477432489395142,
0.017065061256289482,
-0.0022807889617979527,
0.06559956073760986,
-0.04124056547880173,
-0.0014779971679672599,
-0.0007067435653880239,
-0.0126841114833951,
-0.022730477154254913,
0.03259335085749626,
0.013693335466086864,
-0.001834952854551375,
-0.01756967231631279,
0.020929930731654167,
0.00434654438868165,
0.016193458810448647,
0.002626276109367609,
-0.010602586902678013,
0.010292937979102135,
0.006938415113836527,
0.020849650725722313,
0.03142356500029564,
-0.04034602642059326,
0.07564593106508255,
0.0032599084079265594,
0.036125633865594864,
-0.01734030432999134,
0.003328719176352024,
0.015172765590250492,
0.010333077982068062,
0.006858136039227247,
0.0009920214070007205,
-0.0006533435662277043,
0.02015007473528385,
0.007139113266021013,
-0.0025617661885917187,
0.01645723357796669,
0.010700068436563015,
0.022524045780301094,
-0.008721760474145412,
0.02058587595820427,
-0.0005963596631772816,
0.02892344444990158,
-0.005559333600103855,
-0.009541754610836506,
-0.01079181581735611,
-0.026171013712882996,
0.024886546656489372,
-0.0005404509720392525,
-0.0327768437564373,
0.00023814963060431182,
0.014943396672606468,
0.007081770803779364,
-0.010602586902678013,
-0.010625523515045643,
0.027524292469024658,
0.06431509554386139,
0.0050833928398787975,
-0.00459024915471673,
0.008308895863592625,
-0.022913973778486252,
-0.022810757160186768,
-0.008721760474145412,
-0.02353326976299286,
0.03651556000113487,
-0.01160607673227787,
-0.03470354527235031,
0.014266758225858212,
-0.010069303214550018,
-0.011055590584874153,
0.00914609245955944,
0.073076993227005,
0.008870850317180157,
0.02267313562333584,
-0.04995658993721008,
0.03667612001299858,
0.0008407810819335282,
-0.03931386396288872,
0.02230614423751831,
0.03105657547712326,
0.0008730361587367952,
0.03516228497028351,
-0.0019223997369408607,
-0.045965567231178284,
0.002146034734323621,
0.023005720227956772,
0.025804024189710617,
0.0055077257566154,
-0.029749171808362007,
0.00832036416977644,
-0.032180484384298325,
0.018464213237166405,
0.002335264114663005,
-0.01650310680270195,
-0.025826960802078247,
0.026859121397137642,
0.047571152448654175,
0.024037880823016167,
-0.016606323421001434,
-0.010797549970448017,
0.016927439719438553,
-0.032203420996665955,
-0.018418338149785995,
-0.016032900661230087,
0.024794800207018852,
0.037800028920173645,
-0.022879566997289658,
-0.03887806087732315,
0.001513836090452969,
0.00929518323391676,
-0.05605780705809593,
-0.031905241310596466,
0.047479402273893356,
-0.01622786372900009,
0.0330062136054039,
-0.02490948513150215,
0.005998001899570227,
0.018808266147971153,
0.004446893464773893,
0.009862870909273624,
0.01782197877764702,
-0.020012453198432922,
-0.010378952138125896,
-0.018555959686636925,
-0.029817983508110046,
0.011474189348518848,
0.008457985706627369,
-0.01548241451382637,
0.025781087577342987,
0.03663024678826332,
0.002351033268496394,
-0.019760148599743843,
0.011485657654702663,
-0.006347789894789457,
0.016743944957852364,
0.007999246940016747,
0.013016696088016033,
-0.00366990570910275,
0.0030190707184374332,
-0.03316677361726761,
-0.026629753410816193,
0.012477679178118706,
-0.010275735519826412,
0.04257090389728546,
0.014691091142594814,
-0.0013819488231092691,
-0.03458886221051216,
-0.010470699518918991,
-0.00891098938882351,
0.04284614697098732,
-0.05481921508908272,
-0.0005150053184479475,
-0.003910743165761232,
0.009673641994595528,
-0.018555959686636925,
0.026560941711068153,
0.028327083215117455,
0.049773093312978745,
0.007615054026246071,
0.02497829496860504,
-0.003781723091378808,
0.030437279492616653,
-0.00815980602055788,
0.02520766481757164,
0.007706801872700453,
-0.009948885068297386,
-0.0161590538918972,
0.043901246041059494,
-0.02010420151054859,
-0.016675133258104324,
0.0002349241403862834,
-0.0009812696371227503,
0.0067262486554682255,
0.009971821680665016,
0.007081770803779364,
-0.002250684192404151,
-0.010556712746620178,
0.01568884588778019,
-0.02516178973019123,
0.02945099212229252,
-0.0075577120296657085,
-0.016893034800887108,
-0.008566935546696186,
-0.0316988080739975,
0.000541167741175741,
-0.009989024139940739,
0.01745498925447464,
0.014691091142594814,
0.038098208606243134,
-0.025987518951296806,
0.009822731837630272,
0.009478677995502949,
-0.04821338504552841,
-0.01664072833955288,
-0.004352278541773558,
0.01568884588778019,
0.0028613796457648277,
-0.007643725257366896,
-0.021709784865379333,
0.004704933613538742,
-0.024565430358052254,
-0.016675133258104324,
-0.053305380046367645,
0.026262762024998665,
0.021744191646575928,
-0.02008126489818096,
-0.024748925119638443,
0.025941645726561546,
-0.006112686358392239,
-0.04890149086713791,
-0.023808512836694717,
0.022810757160186768,
-0.01970280520617962,
-0.04458935186266899,
0.00861280970275402,
0.04211216792464256,
-0.00969084445387125,
-0.002305159345269203,
0.028189461678266525,
-0.02529941126704216,
0.026492131873965263,
-0.013980046845972538,
0.009467209689319134,
-0.018131626769900322,
0.018957355991005898,
0.02527647465467453,
-0.01450759544968605,
-0.02534528635442257,
0.00985140260308981,
0.009495880454778671,
-0.003681374015286565,
0.006141357589513063,
-0.028671137988567352,
0.005906254518777132,
0.0015883810119703412,
0.0035924934782087803,
0.005711290519684553,
0.017856383696198463,
0.022845162078738213,
-0.01356718223541975,
-0.009862870909273624,
-0.01260383240878582,
0.016881566494703293,
-0.00004291710865800269,
0.012810264714062214,
0.008177008479833603,
0.0021489018108695745,
0.023246558383107185,
0.02012713812291622,
-0.003179629100486636,
0.005737094674259424,
-0.020574407652020454,
-0.035965073853731155,
0.04637843370437622,
-0.028694074600934982,
-0.035965073853731155,
0.05183741822838783,
0.0035437527112662792,
-0.018601834774017334,
-0.002738093724474311,
0.021962091326713562,
0.0067262486554682255,
0.021790064871311188,
-0.017145339399576187,
0.026193952187895775,
0.03913036733865738,
-0.02230614423751831,
-0.0032885794062167406,
0.024703051894903183,
-0.007563446182757616,
-0.011474189348518848,
-0.010011961683630943,
-0.020390912890434265,
0.016101710498332977,
-0.009060079231858253,
-0.020345039665699005,
-0.0003816845128312707,
0.014369973912835121,
0.021755659952759743,
0.05312188342213631,
0.010522307828068733,
-0.022707540541887283,
0.04486459493637085,
-0.0010615488281473517,
-0.030368469655513763,
-0.0000022399326553568244,
-0.020413849502801895,
-0.019163789227604866,
-0.015952620655298233,
-0.02130838856101036,
-0.007850157096982002,
0.0002616241399664432,
-0.0032054332550615072,
0.015574161894619465,
-0.032203420996665955,
0.003575290786102414,
-0.016308143734931946,
-0.021572163328528404,
-0.021813001483678818,
0.018624771386384964,
0.009071547538042068,
-0.036194443702697754,
-0.0005727059906348586,
-0.026079267263412476,
-0.03098776564002037,
0.009277979843318462,
-0.005863247439265251,
0.0029961338732391596,
0.020998740568757057,
0.023808512836694717,
0.03270803391933441,
0.002947392873466015,
-0.007907499559223652,
-0.010419091209769249,
-0.001077317981980741,
-0.07541655749082565,
0.04280027374625206,
-0.0029674626421183348,
-0.0056424797512590885,
0.009599097073078156,
-0.01736324094235897,
-0.012351525947451591,
-0.026538005098700523,
-0.009650704450905323,
-0.0078673604875803,
-0.024313123896718025,
0.024037880823016167,
-0.015367729589343071,
0.014863117597997189,
0.02058587595820427,
-0.009214903227984905,
-0.043992992490530014,
0.004051231779158115,
0.0017632750095799565,
0.006921212654560804,
-0.0006726965657435358,
-0.022868098691105843,
-0.014071794226765633,
0.00883071031421423,
-0.01176663488149643,
0.007924702018499374,
0.0009576160227879882,
0.012225372716784477,
0.009685110300779343,
-0.02910693921148777,
0.021503353491425514,
-0.002409809036180377,
0.027753660455346107,
-0.03697429969906807,
0.014920460060238838,
-0.0024528158828616142,
-0.007162050344049931,
0.03729541599750519,
0.029496867209672928,
0.009019940160214901,
-0.03663024678826332,
0.0046619269996881485,
-0.04816751182079315,
0.0126841114833951,
-0.021595099940896034,
-0.0032570413313806057,
0.0028083380311727524,
0.02216852270066738,
-0.03344201669096947,
-0.0070875054225325584,
0.012844669632613659,
-0.0019797419663518667,
0.0032914464827626944,
0.019748680293560028,
0.011135869659483433,
-0.011715026572346687,
-0.027524292469024658,
-0.009553222917020321,
0.01084915827959776,
0.015918215736746788,
0.007626522798091173,
-0.019806021824479103,
0.03633206710219383,
-0.03637794032692909,
0.04711241275072098,
0.009002736769616604,
0.01578059419989586,
-0.010166785679757595,
-0.06160854175686836,
0.007035897113382816,
0.01448465883731842,
-0.002578968880698085,
0.018670644611120224,
0.0231433417648077,
-0.00281407218426466,
-0.008916723541915417,
0.05477334186434746,
-0.0006067529320716858,
0.0037301150150597095,
0.03511640802025795,
-0.02341858483850956,
-0.0049056317657232285,
0.004022560548037291,
0.005413110833615065,
0.005803038366138935,
-0.007483167108148336,
-0.028304146602749825,
-0.0039480156265199184,
-0.016067305579781532,
-0.00018672079022508115,
0.017925195395946503,
-0.007534774951636791,
-0.0007081771036610007,
-0.0010622655972838402,
-0.04312139004468918,
-0.05564494431018829,
-0.0010479300981387496,
0.014943396672606468,
-0.01063125766813755,
0.011451252736151218,
-0.004983043763786554,
0.014186479151248932,
0.035850390791893005,
-0.0034520048648118973,
-0.024496620520949364,
0.0589478574693203,
0.0007346979109570384,
-0.009782591834664345,
-0.004745073150843382,
0.02305159531533718,
0.017741700634360313,
-0.010556712746620178,
-0.019026167690753937,
-0.0188426710665226,
-0.0017948132008314133,
0.027570165693759918,
-0.02539115957915783,
0.017328836023807526,
0.04023133963346481,
-0.0011217582505196333,
0.006124155130237341,
0.012018940411508083,
-0.009249309077858925,
0.0372266061604023,
-0.0019051970448344946,
0.0012866172473877668,
-0.003867736551910639,
0.014392911456525326,
-0.04043777287006378,
0.01017825398594141,
0.017007719725370407,
0.0006006603362038732,
0.0009547488880343735,
0.05284664034843445,
0.02550584450364113,
-0.043763622641563416,
-0.006336321588605642,
0.024198440834879875,
0.02559759095311165,
0.003397529711946845,
0.016113178804516792,
-0.006278979126363993,
-0.010000492446124554,
-0.014255289919674397,
0.0291298758238554,
-0.013383687473833561,
-0.055323828011751175,
0.01364746131002903,
0.02070056088268757,
-0.0000035138943985657534,
0.02504710666835308,
-0.01259236317127943,
-0.020643219351768494,
-0.0010565314441919327,
-0.0187279861420393,
-0.009662173688411713,
-0.02353326976299286,
-0.004206055775284767,
-0.0029115539509803057,
-0.041768115013837814,
-0.018051348626613617,
-0.016938908025622368,
-0.010900766588747501,
0.04486459493637085,
-0.01470255944877863,
-0.010940905660390854,
0.006210168357938528,
-0.0108032850548625,
-0.03250160068273544,
-0.004082770086824894,
-0.021790064871311188,
0.0016915971646085382,
0.0176155474036932,
-0.008326098322868347,
-0.024519557133316994,
0.013888299465179443,
-0.010149582289159298,
-0.0000850726428325288,
-0.04415355250239372,
-0.005688353907316923,
0.021824469789862633,
0.009811263531446457,
-0.007574914488941431,
0.031744685024023056,
0.0029875326436012983,
-0.028648201376199722,
-0.01782197877764702,
0.0017776105087250471,
-0.0016973313177004457,
0.017443520948290825,
-0.019794553518295288,
-0.03433655574917793,
-0.0110154515132308,
-0.003821862628683448,
0.007586382795125246,
-0.018131626769900322,
-0.028304146602749825,
0.014817243441939354,
-0.03509347140789032,
-0.006451006047427654,
-0.009788325987756252,
0.01829218491911888,
0.01472549606114626,
0.008274490013718605,
-0.03835051506757736,
-0.00005980619971523993,
-0.006055344361811876,
0.020345039665699005,
0.015184234827756882,
0.018062816932797432,
-0.007184986956417561,
-0.008756165392696857,
0.009966087527573109,
0.017936663702130318,
-0.020780840888619423,
0.012041877955198288,
0.04259384050965309,
-0.03490997850894928,
-0.0001151325341197662,
0.012133625335991383,
0.010774613358080387,
-0.049543727189302444,
-0.017260024324059486,
-0.025872834026813507,
0.00008771575812716037,
0.016606323421001434,
-0.03357963636517525,
0.006617298349738121,
0.020000984892249107,
0.0021517688874155283,
0.007540509104728699,
0.010126645676791668,
-0.045873820781707764,
0.02552878111600876,
-0.01364746131002903,
-0.019840426743030548,
0.010436293669044971,
-0.025849897414445877,
-0.009513083845376968,
0.021136362105607986,
0.024565430358052254,
0.008779102005064487,
0.03252453729510307,
0.000642591854557395,
-0.012190967798233032,
0.014324100688099861,
0.0014127703616395593,
-0.006680374965071678,
-0.011715026572346687,
0.004145846702158451,
-0.017764637246727943,
0.020689092576503754,
-0.005347167141735554,
-0.007574914488941431,
0.0332355834543705,
0.0330062136054039,
-0.035804517567157745,
-0.0038734707050025463,
-0.04681423306465149,
-0.026583878323435783,
-0.00673198327422142,
-0.001581213204190135,
0.11633601039648056,
-0.023992007598280907,
0.011325099505484104,
0.015161297284066677,
0.016606323421001434,
-0.025781087577342987,
0.007987778633832932,
-0.0077870809473097324,
0.00885364692658186,
-0.03649262338876724,
0.027891281992197037,
0.004220391623675823,
0.039543233811855316,
0.011835445649921894,
0.024381935596466064,
-0.031836431473493576,
0.006043875589966774,
0.06440684199333191,
-0.017076529562473297,
-0.029680361971259117,
0.017810510471463203,
0.02947392873466015,
-0.009966087527573109,
0.01745498925447464,
-0.026400383561849594,
0.010212658904492855,
-0.0026664158795028925,
-0.0033086491748690605,
-0.0032341042533516884,
-0.008251553401350975,
0.022845162078738213,
0.009937415830790997,
0.015597098506987095,
-0.02165244333446026,
-0.011101464740931988,
-0.018693581223487854,
-0.0015883810119703412,
-0.020436786115169525,
0.009025674313306808,
0.028304146602749825,
-0.0013418092858046293,
0.007626522798091173,
0.007465964183211327,
-0.003755918936803937,
0.032226357609033585,
0.007597851566970348,
-0.022776352241635323,
0.007173518650233746,
0.01636548526585102,
-0.024336062371730804,
0.007357013877481222,
-0.009369728155434132,
0.01558563020080328,
-0.0028556452598422766,
-0.043763622641563416,
-0.01582646742463112,
0.028281209990382195,
0.008188476786017418,
-0.009558957070112228,
-0.04534627124667168,
-0.016835691407322884,
0.01270704809576273,
0.00033616909058764577,
-0.0086930887773633,
0.015700314193964005
] | 2025-01-03 | 43 | 39751840 | [
"CAR T cells",
"T cell infiltration",
"T cells",
"T cell therapy",
"solid tumors",
"various solid tumor types",
"tumor tissues",
"tumors",
"inadequate infiltration",
"CCR5",
"diminished effector function",
"key chemokines",
"CAR",
"limited proliferation",
"significant challenges",
"Chimeric antigen receptor",
"single-cell immunoprofiling",
"CCL5",
"an immunosuppressive tumor microenvironment",
"TME",
"CCL4",
"The Cancer Genome Atlas database",
"macrophages",
"The Cancer Genome Atlas",
"CD8",
"The CCL4/CCL5-CCR5 axis",
"their migratory capacity",
"the TME",
"the presence",
"the expression"
] | [
"CAR T cells",
"CCR5",
"IL-12",
"Tumor Mircoenvironment"
] | 0 | 10.1007/s00262-024-03909-w | [
"Tian",
"Zhang",
"Ping",
"Zhang",
"Yao",
"Shen",
"Li",
"Wen",
"Zhang"
] | [
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.\nDepartment of Laboratory Medicine, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.",
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.",
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.",
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.",
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.",
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.",
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.\nState Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, 450052, Henan, China.",
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.",
"Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. [email protected].\nState Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, 450052, Henan, China. [email protected].\nTianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China. [email protected].\nSchool of Public Health, Zhengzhou University, Zhengzhou, Henan, China. [email protected].\nSchool of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China. [email protected]."
] | [
"39751840",
"37904019",
"34613616",
"37706523",
"38244129",
"37254607",
"34234299",
"31848460",
"31488817",
"36261831",
"28543380",
"37861969",
"33463538",
"38511468",
"35351469",
"33563975",
"27625360",
"30671927",
"26284335",
"33293583",
"32561858",
"27003285",
"25563480",
"39208806",
"31570880",
"32423475",
"32735779",
"21610146",
"35697686",
"31142602",
"36167468",
"32015548",
"38408567",
"38550594",
"38788547",
"17237382",
"33418929",
"38136398",
"32706785",
"35183252",
"32946772",
"29505028",
"32816947"
] | [] | 9.83024 | 5.137157 |
39750051 | 83 | [Anti-tumor therapy strategy of CAR-T cells based on stem cell memory and central memory cells]. | Cancer immunotherapy including immune checkpoint inhibitors and adoptive cell therapy has gained revolutionary success in the treatment of hematologic tumors; however, it only gains limited success in solid tumors. For example, chimeric antigen receptor T (CAR-T) cell therapy has shown significant effects and potential for curing patients with B-cell malignancies. In contrast, it remains a challenge for CAR-T cell therapy to gain similar success in solid tumors. The anti-tumor effect of endogenous or adoptively transferred tumor-specific T cells depends largely on their differentiation status. T cells at early differentiation stage show better anti-tumor therapeutic effects than fully differentiated effector T cells. In cancer patients, the persistence of tumor-specific T cells with the stem cell memory or precursor phenotype is significantly associated with improved therapeutic outcomes; therefore, adoptively transfered CAR-T cells with stem cell memory and/or central memory is expected to gain better anti-tumor effects. Herein we focused on the in vitro optimized culture and expansion system to obtain CAR-T cells with stem cell memory or central memory phenotype for the review. | [
0.030005916953086853,
0.0048876493237912655,
0.027880851179361343,
0.05835428088903427,
-0.01640550047159195,
-0.029113389551639557,
0.0021981140598654747,
0.03051593154668808,
0.02006061188876629,
-0.013653541915118694,
-0.009127154015004635,
-0.021048767492175102,
-0.056101713329553604,
-0.005833303090184927,
0.007373975124210119,
-0.017786793410778046,
0.056101713329553604,
-0.0011508554453030229,
0.02953840233385563,
0.006290192250162363,
0.0395687073469162,
0.024013232439756393,
0.016256745904684067,
-0.013823547400534153,
-0.0332997664809227,
-0.00632206816226244,
-0.021994421258568764,
0.01370666828006506,
-0.03298100829124451,
-0.030388427898287773,
-0.004483886994421482,
-0.017128022387623787,
-0.024884508922696114,
-0.052659109234809875,
-0.003766677575185895,
0.06260441243648529,
0.026669563725590706,
0.00902090035378933,
-0.006651453208178282,
-0.025522029027342796,
0.041120003908872604,
0.030898442491889,
0.014811702072620392,
0.10718826949596405,
-0.05652672424912453,
-0.008739328943192959,
-0.002099829725921154,
-0.06069185212254524,
-0.029517151415348053,
-0.004762801807373762,
-0.04222504049539566,
-0.01846681348979473,
-0.004919525235891342,
0.021718163043260574,
-0.043733835220336914,
0.04496637359261513,
-0.02484200894832611,
0.006810832768678665,
-0.011613479815423489,
0.03051593154668808,
0.0066673909313976765,
-0.004462636075913906,
0.024268241599202156,
-0.02626580186188221,
-0.018137428909540176,
-0.01832868531346321,
-0.07055215537548065,
-0.04870648682117462,
-0.0025261708069592714,
0.026032045483589172,
0.009222781285643578,
-0.0012066384078934789,
0.010237500071525574,
-0.0067789568565785885,
0.02138877846300602,
0.008840270340442657,
0.01651175506412983,
0.02528827264904976,
0.017425531521439552,
-0.011815360747277737,
0.021271899342536926,
-0.005081561394035816,
0.032449740916490555,
-0.040461234748363495,
-0.024161987006664276,
-0.012452879920601845,
0.022929450497031212,
-0.02783834934234619,
-0.015512974001467228,
-0.018063051626086235,
0.017043020576238632,
0.03344852104783058,
-0.01696864329278469,
0.030983446165919304,
0.00567923579365015,
0.012049118056893349,
-0.02282319776713848,
-0.07161469012498856,
0.03689112514257431,
0.029219642281532288,
0.04037623107433319,
0.016841139644384384,
-0.03723113611340523,
-0.009621230885386467,
0.03327851742506027,
-0.0031371270306408405,
-0.055931705981492996,
-0.03200347721576691,
-0.0006537894951179624,
0.0024504654575139284,
0.05389164388179779,
-0.03389478474855423,
-0.0052117216400802135,
0.034468553960323334,
-0.03935620188713074,
-0.07705485075712204,
-0.009732796810567379,
-0.004683111794292927,
-0.0005760918138548732,
0.041332513093948364,
-0.002125064842402935,
0.017712416127324104,
0.016416126862168312,
-0.026690814644098282,
0.0047123315744102,
-0.025054514408111572,
0.10174810886383057,
-0.038272418081760406,
-0.027222082018852234,
-0.06069185212254524,
0.020039360970258713,
-0.008420569822192192,
0.023673223331570625,
-0.019114958122372627,
-0.058056771755218506,
-0.015353593975305557,
-0.014078554697334766,
0.0019191992469131947,
0.004861086141318083,
-0.01807367615401745,
0.02069813199341297,
-0.03023967333137989,
-0.025649532675743103,
-0.010210936889052391,
-0.0338735356926918,
-0.039143696427345276,
-0.006741768214851618,
0.03068593703210354,
0.005918305832892656,
0.06273191422224045,
-0.028837131336331367,
0.07029714435338974,
0.06914961338043213,
0.0035037007182836533,
0.005572982598096132,
0.012017241679131985,
-0.004412165842950344,
0.05384914577007294,
-0.032555993646383286,
-0.04048248752951622,
-0.02637205459177494,
-0.0024531218223273754,
-0.016766762360930443,
-0.028348365798592567,
0.00039546130574308336,
-0.014854203909635544,
-0.022164426743984222,
0.013717293739318848,
-0.05134156718850136,
-0.006067060399800539,
-0.014992333017289639,
-0.05559169873595238,
-0.06421945989131927,
0.0130266472697258,
-0.031684719026088715,
0.008638388477265835,
0.018488064408302307,
0.02337571419775486,
-0.008872145786881447,
-0.002786491299048066,
0.022844446823000908,
0.024650752544403076,
-0.005939556285738945,
0.02779584936797619,
-0.005780176259577274,
0.024183237925171852,
-0.009329034946858883,
0.03508482128381729,
-0.026180800050497055,
-0.01517296303063631,
0.008505572564899921,
-0.033427271991968155,
0.03550983592867851,
-0.0014623103197664022,
0.002439840231090784,
0.0002860536624211818,
0.030707187950611115,
0.012484756298363209,
-0.007735236082226038,
-0.015321717597544193,
0.021994421258568764,
-0.030112169682979584,
-0.06583450734615326,
0.005657985340803862,
-0.02832711488008499,
-0.03856992721557617,
-0.03417104482650757,
0.04092875123023987,
-0.022589439526200294,
-0.017298027873039246,
0.016522379592061043,
-0.00012683980457950383,
-0.02518201805651188,
0.025649532675743103,
-0.048578985035419464,
-0.004316538106650114,
-0.007145530544221401,
0.03846367448568344,
0.01654363051056862,
0.026520809158682823,
0.007719298359006643,
-0.026733316481113434,
-0.0022804602049291134,
0.004263411276042461,
-0.027179580181837082,
0.015544849447906017,
-0.003995121922343969,
-0.02452324889600277,
-0.03325726464390755,
-0.019624974578619003,
-0.034787312150001526,
0.00012576067820191383,
0.006492073182016611,
-0.02173941396176815,
-0.03181222081184387,
-0.04001497104763985,
0.013483536429703236,
-0.0033363518305122852,
0.05907680466771126,
-0.01710677146911621,
0.00025251746410503983,
0.03508482128381729,
0.023120705038309097,
-0.03298100829124451,
-0.017638038843870163,
0.0038835559971630573,
-0.002834305400028825,
-0.06243440508842468,
0.02615954913198948,
-0.023800726979970932,
0.005477354861795902,
-0.009153717197477818,
0.012867268174886703,
0.027647094801068306,
0.025373274460434914,
0.014779826626181602,
0.06196689233183861,
-0.03731613978743553,
0.017786793410778046,
-0.02773209661245346,
-0.028922133147716522,
0.01905120722949505,
-0.020846886560320854,
-0.04156626760959625,
-0.08224000781774521,
0.017616787925362587,
-0.0008726047817617655,
0.0049487450160086155,
0.036912377923727036,
-0.000996788265183568,
0.01996498368680477,
0.005456103943288326,
0.0569942407310009,
-0.02229193039238453,
-0.021781915798783302,
0.013536663725972176,
-0.03848492354154587,
0.033002257347106934,
0.02013498917222023,
0.012676011770963669,
-0.020804384723305702,
0.018689945340156555,
-0.00938747450709343,
-0.017329903319478035,
-0.0065664504654705524,
-0.019561221823096275,
0.001019367016851902,
0.0070020887069404125,
-0.003923401236534119,
-0.04120500758290291,
0.00827181525528431,
-0.011496600694954395,
-0.027264581993222237,
-0.009817799553275108,
-0.017287403345108032,
0.008091184310615063,
-0.017893046140670776,
0.0038463673554360867,
-0.037082381546497345,
0.0443713553249836,
-0.02919839136302471,
-0.02190941944718361,
-0.03083469159901142,
-0.02316320687532425,
0.030282175168395042,
0.016214245930314064,
-0.006598326377570629,
-0.007554605603218079,
0.05695173889398575,
0.03731613978743553,
0.01947622001171112,
0.012080993503332138,
0.034086041152477264,
0.04184252768754959,
-0.012888518162071705,
0.0318334735929966,
0.016277996823191643,
-0.07169968634843826,
0.010455319657921791,
-0.04041873291134834,
-0.04619891196489334,
-0.03667861968278885,
-0.05393414571881294,
0.055336687713861465,
0.02707332745194435,
-0.021271899342536926,
-0.0012942972825840116,
-0.016214245930314064,
0.03128095343708992,
-0.025309523567557335,
0.008250564336776733,
-0.04190627858042717,
0.07743736356496811,
-0.021951919421553612,
0.030154671519994736,
-0.03125970438122749,
-0.01814805343747139,
-0.04167252406477928,
0.027200831100344658,
0.014971082098782063,
-0.0011667934013530612,
0.03978121280670166,
-0.04322382062673569,
0.06523948907852173,
-0.0035249514039605856,
-0.02456575073301792,
-0.008760579861700535,
0.054019149392843246,
0.007379287853837013,
0.026117047294974327,
0.0156723540276289,
0.028858380392193794,
0.018870575353503227,
0.01077939197421074,
-0.017542410641908646,
0.02522451989352703,
-0.04037623107433319,
-0.035276077687740326,
0.02484200894832611,
-0.016246121376752853,
0.03062218427658081,
-0.015236714854836464,
-0.027434587478637695,
0.03361852467060089,
0.045688893646001816,
0.04483886808156967,
-0.03521232679486275,
0.03952620550990105,
-0.017234276980161667,
-0.037294887006282806,
-0.036529865115880966,
0.009291846305131912,
0.027370836585760117,
0.01599111407995224,
-0.0443713553249836,
0.04772895574569702,
0.022079424932599068,
0.041545018553733826,
0.0045370133593678474,
0.016958016902208328,
0.032173480838537216,
-0.010024993680417538,
-0.01606549136340618,
0.0029246206395328045,
-0.0019895920995622873,
0.0214525293558836,
0.05389164388179779,
-0.003769333939999342,
-0.09129279106855392,
0.03204597905278206,
-0.005286098923534155,
0.0014556694077327847,
0.014418565668165684,
0.008845582604408264,
-0.011985366232693195,
0.06630202382802963,
-0.060011833906173706,
0.05695173889398575,
0.03497856855392456,
-0.0006069716764613986,
0.00945653859525919,
-0.02647830918431282,
0.003758708480745554,
-0.05695173889398575,
0.03567983955144882,
-0.021378152072429657,
0.036806125193834305,
0.0025115611497312784,
0.04114125669002533,
-0.027285832911729813,
0.025309523567557335,
0.0007610388565808535,
0.0337885320186615,
0.02212192490696907,
-0.024820758029818535,
-0.012814140878617764,
-0.043393824249506,
0.04407384619116783,
-0.011422223411500454,
0.00885089486837387,
0.020018111914396286,
-0.019146835431456566,
0.008574636653065681,
-0.030919693410396576,
-0.000046817836846457794,
0.005610171239823103,
0.03499981760978699,
0.03312976285815239,
-0.024990763515233994,
-0.049386508762836456,
-0.028433367609977722,
0.057079244405031204,
0.011156590655446053,
-0.003381509566679597,
-0.01717052422463894,
0.03334226831793785,
-0.0362323559820652,
0.02229193039238453,
-0.050151530653238297,
0.00898902490735054,
-0.04462636262178421,
-0.01745740883052349,
0.014854203909635544,
-0.03878243267536163,
0.0318334735929966,
0.016458626836538315,
0.008245252072811127,
0.01909370720386505,
-0.036317359656095505,
-0.04636891558766365,
-0.01703239418566227,
-0.032513491809368134,
-0.003995121922343969,
0.017648663371801376,
-0.030664686113595963,
0.011485975235700607,
0.02348196692764759,
-0.04411634802818298,
0.006927711423486471,
0.01609736680984497,
0.028475869446992874,
-0.04500887542963028,
0.037082381546497345,
-0.05444416403770447,
0.0046193599700927734,
0.04320256784558296,
0.04226754233241081,
-0.013536663725972176,
0.012984146364033222,
-0.05087405443191528,
0.026350803673267365,
-0.005450791213661432,
0.000871276599355042,
-0.005881117191165686,
-0.004436072893440723,
0.023906979709863663,
0.019933108240365982,
0.02734958566725254,
-0.0017903671832755208,
-0.001664191484451294,
-0.005955494474619627,
0.0023110080510377884,
-0.03786865621805191,
-0.017064271494746208,
0.038718681782484055,
-0.0024504654575139284,
-0.020538752898573875,
-0.018233057111501694,
-0.0540616512298584,
0.027668343856930733,
-0.014152931980788708,
-0.02180316485464573,
0.0018780260579660535,
-0.0069011482410132885,
-0.028050856664776802,
-0.013494161888957024,
0.017340529710054398,
-0.013143526390194893,
-0.01501358300447464,
0.009366223588585854,
0.013557913713157177,
0.03665737062692642,
-0.012187247164547443,
0.04866398498415947,
0.027179580181837082,
0.02054937742650509,
0.023226959630846977,
0.054954178631305695,
0.030898442491889,
0.020560001954436302,
-0.025543279945850372,
-0.0015977831790223718,
0.038931187242269516,
-0.0008201422169804573,
-0.01454606931656599,
-0.020294370129704475,
-0.05006652697920799,
0.009706233628094196,
-0.009169654920697212,
-0.013536663725972176,
-0.010513758286833763,
0.0005850568995811045,
-0.015385469421744347,
-0.006736455485224724,
0.023396965116262436,
-0.02866712585091591,
-0.023503217846155167,
-0.026882071048021317,
-0.021367527544498444,
-0.008107122965157032,
0.015767982229590416,
-0.013462286442518234,
0.010954709723591805,
-0.005264848470687866,
0.015512974001467228,
-0.014174182899296284,
-0.054359160363674164,
0.05193658545613289,
-0.037507396191358566,
-0.026627063751220703,
0.014705449342727661,
-0.01828618347644806,
0.02681831829249859,
-0.004744207486510277,
-0.0031424397602677345,
0.027923353016376495,
-0.02201567217707634,
-0.02170753851532936,
0.035169824957847595,
-0.032619744539260864,
0.013217903673648834,
-0.05040653795003891,
0.01891307719051838,
0.0052675046026706696,
0.023290710523724556,
-0.022206928580999374,
-0.02445949614048004,
-0.022971950471401215,
-0.010736890137195587,
0.004768114537000656,
-0.016501128673553467,
-0.010280000977218151,
0.022971950471401215,
-0.031238453462719917,
-0.010901582427322865,
0.035722341388463974,
-0.00440685311332345,
-0.022249428555369377,
-0.019316839054226875,
0.03051593154668808,
-0.01038094237446785,
0.007921179756522179,
0.0037268325686454773,
-0.022546937689185143,
0.040843747556209564,
0.009881551377475262,
-0.0205175019800663,
0.01828618347644806,
-0.003370884107425809,
0.02343946509063244,
-0.029028385877609253,
-0.008107122965157032,
-0.020475000143051147,
0.058014269918203354,
0.007448352407664061,
0.02006061188876629,
-0.04065249115228653,
-0.007862740196287632,
-0.013472910970449448,
-0.017128022387623787,
0.033384770154953,
-0.003211504314094782,
0.04043998569250107,
-0.014365438371896744,
-0.024693254381418228,
0.03298100829124451,
0.0070233396254479885,
-0.0009217468905262649,
-0.00902621354907751,
-0.018403062596917152,
-0.014811702072620392,
-0.000028825343179050833,
0.0034957316238433123,
-0.042033784091472626,
0.006598326377570629,
0.03444730117917061,
-0.01748928427696228,
-0.026223300024867058,
0.014269811101257801,
-0.0065717631950974464,
0.05605921149253845,
0.027222082018852234,
-0.04466886445879936,
0.016958016902208328,
0.027158329263329506,
0.00632206816226244,
-0.02037937194108963,
-0.004470605403184891,
-0.004300599917769432,
-0.028050856664776802,
-0.021516282111406326,
0.000609960057772696,
-0.03693362697958946,
0.003211504314094782,
-0.020985016599297523,
-0.032067228108644485,
-0.007852114737033844,
0.002423902042210102,
0.03176971897482872,
0.00610424904152751,
-0.008680890314280987,
-0.014811702072620392,
-0.012814140878617764,
0.027328334748744965,
-0.004600765649229288,
-0.038229916244745255,
0.017340529710054398,
-0.02160128392279148,
-0.012580384500324726,
0.02065563015639782,
-0.030494680628180504,
0.0013381268363445997,
-0.019359340891242027,
-0.00783617701381445,
0.02473575435578823,
0.0014822327066212893,
-0.030983446165919304,
-0.002684222534298897,
0.0046485792845487595,
-0.013334781862795353,
0.0069117737002670765,
-0.04815397039055824,
0.04959901422262192,
-0.03491481766104698,
0.010152497328817844,
-0.004452011082321405,
0.008702140301465988,
-0.012102244421839714,
0.05486917495727539,
0.0541466549038887,
-0.03905869275331497,
-0.0012551164254546165,
-0.01950809545814991,
0.0007377959555014968,
0.006125499494373798,
0.002211395651102066,
0.00007060029747663066,
0.0066620782017707825,
0.014429190196096897,
0.0022485842928290367,
0.06689704209566116,
0.0020613130182027817,
0.007480228319764137,
-0.028157109394669533,
-0.005663298070430756,
0.017584912478923798,
-0.014067929238080978,
-0.020464375615119934,
-0.01119909156113863,
0.004555607680231333,
-0.025373274460434914,
0.0003493075491860509,
-0.03291725367307663,
-0.05036403611302376,
0.0035010443534702063,
-0.008117747493088245,
0.02097439020872116,
0.008765893056988716,
0.012899143621325493,
-0.0050337472930550575,
0.005254223011434078,
-0.03491481766104698,
-0.03886743634939194,
-0.019253088161349297,
0.0014649665681645274,
0.02037937194108963,
0.003214160678908229,
0.006242378149181604,
-0.02407698519527912,
-0.027115827426314354,
0.016320498660206795,
0.012506007216870785,
0.04320256784558296,
-0.037464894354343414,
0.023460716009140015,
0.012165996246039867,
0.006380507256835699,
-0.02919839136302471,
0.00038550005410797894,
0.011177841573953629,
0.001605752157047391,
0.004011060111224651,
-0.013972301967442036,
-0.010986585170030594,
0.013961676508188248,
-0.00089916808065027,
-0.011209717020392418,
0.03208848088979721,
0.008006181567907333,
0.027710845693945885,
0.016437377780675888,
0.017818668857216835,
-0.01654363051056862,
0.005971432197839022,
0.03737989068031311,
0.04615641012787819,
-0.04001497104763985,
0.05423165485262871,
-0.019136209040880203,
0.008978399448096752,
-0.00542688462883234,
-0.021516282111406326,
-0.010125934146344662,
-0.016469253227114677,
0.001605752157047391,
0.024927010759711266,
-0.0463264137506485,
-0.02734958566725254,
0.0071295928210020065,
0.009259969927370548,
0.007846802473068237,
-0.037571147084236145,
-0.032173480838537216,
0.011740983463823795,
0.013993551954627037,
0.013090400025248528,
0.010742203332483768,
0.013844797387719154,
0.018063051626086235,
-0.03716738522052765,
0.015289842151105404,
0.004629984963685274,
-0.004914212506264448,
-0.00288211926817894,
0.023354463279247284,
-0.020613130182027817,
0.01668175868690014,
-0.004125282168388367,
-0.03782615438103676,
-0.023120705038309097,
-0.02069813199341297,
-0.004332475829869509,
0.007990243844687939,
0.006226439960300922,
-0.01525796577334404,
0.027519591152668,
0.008447133004665375,
0.020687507465481758,
-0.034128542989492416,
-0.01744678243994713,
-0.004104031715542078,
-0.0270308256149292,
0.003046811791136861,
-0.028050856664776802,
-0.010519071482121944,
0.025692034512758255,
-0.025097016245126724,
-0.0023999952245503664,
-0.014237934723496437,
0.017776167020201683,
0.0007636952213943005,
0.003947307821363211,
-0.015385469421744347,
0.013472910970449448,
-0.006061747670173645,
-0.004019028972834349,
0.014758575707674026,
0.024778256192803383,
0.0028103983495384455,
-0.02155878394842148,
-0.015597975812852383,
0.0541466549038887,
-0.029240893200039864,
0.02992091327905655,
-0.023141955956816673,
0.01658613048493862,
0.044158849865198135,
-0.07599232345819473,
-0.01871119625866413,
0.019327465444803238,
-0.019104333594441414,
-0.010890957899391651,
0.0002882119151763618,
-0.03529732674360275,
-0.016607381403446198,
0.004491855856031179,
-0.019146835431456566,
0.005017809569835663,
-0.025458278134465218,
-0.0009018243872560561,
-0.0010505788959562778,
0.007554605603218079,
-0.012080993503332138,
-0.0047203004360198975,
-0.07271972298622131,
-0.020464375615119934,
0.0304521806538105,
-0.011039712466299534,
-0.003264630911871791,
-0.01748928427696228,
0.031047197058796883,
-0.0048371790908277035,
0.030962195247411728,
-0.0372098870575428,
-0.006152062676846981,
-0.05546419322490692,
-0.04675142839550972,
-0.01509858574718237,
0.017956798896193504,
-0.026117047294974327,
0.028943384066224098,
-0.009339660406112671,
-0.0410350039601326,
0.02581953816115856,
0.004908899776637554,
-0.028369616717100143,
0.00611487403512001,
-0.008319629356265068,
0.000019694205548148602,
0.047218941152095795,
0.0024464810267090797,
-0.008967773988842964,
-0.014609821140766144,
-0.03023967333137989,
0.007639608345925808,
0.0232057087123394,
0.0024464810267090797,
0.02114439569413662,
-0.04539138451218605,
-0.03676362335681915,
-0.01769116520881653,
-0.0005355827743187547,
-0.02445949614048004,
-0.0049939025193452835,
0.02117627114057541,
0.022950701415538788,
0.018615568056702614,
-0.03742239251732826,
0.04998152703046799,
0.04305381327867508,
-0.005711111705750227,
0.012729139067232609,
-0.002231318037956953,
-0.008649013936519623,
0.03276849910616875,
-0.022844446823000908,
0.02086813747882843,
-0.029240893200039864,
0.0108484560623765,
-0.03814491629600525,
0.016012363135814667,
-0.013090400025248528,
-0.007416476495563984,
-0.01515171304345131,
0.008574636653065681,
-0.009695608168840408,
0.023630721494555473,
-0.019178710877895355,
-0.005009840242564678,
-0.002786491299048066,
-0.002297726459801197,
-0.023715723305940628,
-0.0012099588057026267,
-0.018296808004379272,
0.005535793956369162,
0.017159899696707726,
-0.006173313595354557,
0.013207278214395046,
-0.015927361324429512,
-0.0036737059708684683,
0.0048823365941643715,
-0.008176187053322792,
-0.02309945598244667,
0.001522077713161707,
0.0066727036610245705,
-0.007788362912833691,
-0.006247690878808498,
0.029389647766947746,
-0.038442425429821014,
-0.000765023345593363,
-0.02943214774131775,
-0.028475869446992874,
0.003219473408535123,
0.027264581993222237,
0.004568889271467924,
0.008452445268630981,
-0.01790367253124714,
0.037783652544021606,
-0.030855942517518997,
0.042968813329935074,
-0.005785488989204168,
0.0036232357379049063,
-0.002879462903365493,
0.03689112514257431,
-0.011071587912738323,
0.02724333107471466,
-0.029665905982255936,
0.07820238918066025,
0.02681831829249859,
0.013664167374372482,
-0.02343946509063244,
0.002836961532011628,
-0.036423612385988235,
-0.021973170340061188,
-0.010811267420649529,
-0.004422791302204132,
0.0069011482410132885,
0.029559653252363205,
0.013387909159064293,
0.013356032781302929,
0.011241593398153782,
-0.017393656075000763,
0.035998597741127014,
0.01678801327943802,
0.013972301967442036,
0.008526822552084923,
0.02155878394842148,
-0.008675577118992805,
-0.00024687277618795633,
-0.03695487976074219,
-0.03319351375102997,
0.01599111407995224,
-0.0338735356926918,
-0.026010794565081596,
-0.00009454878454562277,
0.014248560182750225,
0.010901582427322865,
-0.034086041152477264,
0.018371185287833214,
0.024884508922696114,
0.05444416403770447,
0.00980717409402132,
0.018264932557940483,
0.015874234959483147,
-0.003272600006312132,
-0.01871119625866413,
0.014089180156588554,
-0.027519591152668,
0.04420134797692299,
-0.007639608345925808,
-0.03846367448568344,
0.006290192250162363,
-0.013090400025248528,
-0.00635925680398941,
0.017149273306131363,
0.04619891196489334,
0.00391011917963624,
0.017436157912015915,
-0.059799324721097946,
0.03835742175579071,
0.01283539179712534,
-0.005509230773895979,
0.024820758029818535,
0.021951919421553612,
0.005684548523277044,
0.01832868531346321,
0.03268349915742874,
-0.03491481766104698,
0.009987805038690567,
0.011230967938899994,
0.023354463279247284,
0.03423479571938515,
-0.024480747058987617,
-0.020007485523819923,
-0.014089180156588554,
0.013101024553179741,
-0.0034983879886567593,
-0.01271851360797882,
-0.028518371284008026,
-0.0035860470961779356,
0.04326632246375084,
0.04273505508899689,
-0.03982371464371681,
-0.028242113068699837,
0.017308654263615608,
-0.03548858314752579,
-0.02180316485464573,
-0.06438946723937988,
0.009674358181655407,
0.0270308256149292,
-0.024693254381418228,
-0.01849868893623352,
0.02041124738752842,
-0.004845147952437401,
-0.02696707285940647,
0.0050948429852724075,
0.022971950471401215,
0.008420569822192192,
0.04794146493077278,
-0.019773729145526886,
0.0304521806538105,
0.009164342656731606,
0.005503918044269085,
0.021866917610168457,
-0.0065770759247243404,
-0.025904541835188866,
0.013069149106740952,
-0.031089698895812035,
-0.03030342608690262,
-0.01880682446062565,
-0.04709143936634064,
-0.009971867315471172,
0.03155721351504326,
0.06630202382802963,
0.01678801327943802,
-0.008117747493088245,
0.014503567479550838,
-0.02375822514295578,
0.008436507545411587,
0.026308303698897362,
0.0181161779910326,
0.004244816955178976,
0.020708756521344185,
-0.02132502570748329,
-0.019986234605312347,
0.023524468764662743,
0.009610606357455254,
0.05673923343420029,
0.029517151415348053,
0.0052117216400802135,
-0.03884618729352951,
0.010402192361652851,
0.009679670445621014,
0.04755895212292671,
-0.02866712585091591,
-0.007400538306683302,
0.003758708480745554,
-0.016416126862168312,
0.025203268975019455,
0.02456575073301792,
0.0034186982084065676,
0.047218941152095795,
0.020528126507997513,
-0.006481447722762823,
-0.009658419527113438,
0.019486844539642334,
0.006035184487700462,
0.017011145129799843,
-0.01874307170510292,
0.0021370183676481247,
-0.022270679473876953,
0.042586300522089005,
0.026010794565081596,
-0.0072358460165560246,
-0.026945821940898895,
-0.0005462080589495599,
0.011709107086062431,
-0.0003928049700334668,
0.01550234854221344,
0.0066673909313976765,
0.007740548811852932,
0.001616377499885857,
-0.03019717149436474,
-0.0015234058955684304,
0.0019311526557430625,
0.00886683352291584,
0.00592361856251955,
-0.0025168736465275288,
0.0020294368732720613,
-0.01463107205927372,
-0.020815011113882065,
0.008473696187138557,
-0.0016801294405013323,
-0.0034558868501335382,
-0.023311961442232132,
0.005296724382787943,
-0.03684862330555916,
-0.025309523567557335,
0.000720529817044735,
-0.006008620839565992,
0.0008008838049136102,
-0.0010100698564201593,
-0.027158329263329506,
-0.007352724671363831,
0.015141087584197521,
-0.011740983463823795,
-0.024225739762187004,
0.014344188384711742,
0.025522029027342796,
-0.006736455485224724,
-0.010428755544126034,
0.01419543381780386,
0.006497385911643505,
-0.016437377780675888,
-0.03971746191382408,
0.06256190687417984,
-0.020995641127228737,
-0.051086559891700745,
0.019242461770772934,
0.039377450942993164,
0.010354378260672092,
0.01386604830622673,
0.019486844539642334,
0.004475918132811785,
0.009074026718735695,
0.007740548811852932,
0.011475350707769394,
-0.01574673131108284,
0.016915516927838326,
0.010699701495468616,
-0.018519939854741096,
-0.035446081310510635,
-0.02870962582528591,
0.016522379592061043,
0.00633269315585494,
-0.014163557440042496,
-0.01490733027458191,
0.01605486497282982,
-0.00885089486837387,
0.019029956310987473,
-0.010901582427322865,
0.00957872997969389,
-0.0065823886543512344,
0.008277127519249916,
-0.01647987775504589,
0.01553422398865223,
-0.007469602860510349,
-0.005177189130336046,
-0.0008467055158689618,
0.013260404579341412,
0.030813440680503845,
0.003995121922343969,
-0.010407505556941032,
-0.008160249330103397,
-0.010184373706579208,
-0.023333212360739708,
-0.006986150983721018,
0.0376136489212513,
-0.017329903319478035,
-0.039696212857961655,
0.051681578159332275,
0.027753347530961037,
-0.025267021730542183,
0.00564204715192318,
-0.0066833291202783585,
0.01943371817469597,
0.021197522059082985,
-0.00937153585255146,
0.029835911467671394,
0.03406478837132454,
-0.03423479571938515,
-0.004050904884934425,
0.010237500071525574,
-0.026690814644098282,
-0.005179845727980137,
0.002765240613371134,
0.0013182043330743909,
0.022546937689185143,
0.039908718317747116,
-0.02407698519527912,
0.006715205032378435,
0.02745583839714527,
0.01675613597035408,
0.030919693410396576,
-0.007644921075552702,
0.017712416127324104,
0.039143696427345276,
-0.013589790090918541,
-0.007841489277780056,
-0.018275557085871696,
-0.01222974807024002,
-0.014864828437566757,
-0.0012637495528906584,
-0.041226260364055634,
-0.012346627190709114,
0.007591794244945049,
-0.002720083110034466,
-0.007937117479741573,
-0.014365438371896744,
0.017499908804893494,
-0.0032513493206351995,
-0.029240893200039864,
-0.005219690501689911,
0.007660858798772097,
0.0017372405854985118,
-0.017425531521439552,
0.004130594898015261,
-0.03667861968278885,
-0.017988674342632294,
0.025139518082141876,
-0.0025142172817140818,
0.01770178973674774,
0.02490575984120369,
-0.003957933280616999,
0.041162505745887756,
0.015236714854836464,
0.012569759041070938,
-0.0008666280191391706,
0.01405730377882719,
-0.07029714435338974,
0.020708756521344185,
-0.017234276980161667,
-0.0025514059234410524,
0.010705014690756798,
-0.021760664880275726,
-0.042203787714242935,
-0.016224870458245277,
-0.0036604241468012333,
-0.009785924106836319,
0.0049487450160086155,
-0.0050948429852724075,
-0.00542688462883234,
0.006258315872400999,
0.0008619794389232993,
0.0016602069372311234,
-0.02926214411854744,
0.003224785905331373,
0.008749954402446747,
-0.011496600694954395,
0.021059393882751465,
-0.006545200012624264,
-0.03829367086291313,
0.0227169431746006,
0.001884666969999671,
-0.006242378149181604,
-0.012792890891432762,
0.0181161779910326,
-0.013334781862795353,
-0.005270160734653473,
0.05967182293534279,
0.005487979855388403,
0.0200287364423275,
-0.028752127662301064,
0.0005339225754141808,
-0.030494680628180504,
-0.0031318143010139465,
0.04619891196489334,
0.014407940208911896,
0.04033373296260834,
-0.02337571419775486,
-0.0031344706658273935,
-0.011677231639623642,
0.0006773644126951694,
-0.03725238889455795,
-0.008096497505903244,
0.008574636653065681,
0.01651175506412983,
-0.029708407819271088,
-0.027158329263329506,
0.002297726459801197,
0.03285350278019905,
-0.007363349664956331,
0.022036923095583916,
-0.02135690115392208,
-0.008356817997992039,
-0.02354571968317032,
0.0016602069372311234,
0.002789147663861513,
0.013876673765480518,
0.027392085641622543,
-0.009568104520440102,
0.033214762806892395,
-0.03051593154668808,
0.043075066059827805,
0.014896704815328121,
0.007251783739775419,
-0.028199611231684685,
-0.05469917133450508,
0.012410379014909267,
-0.004016372840851545,
0.0020785790402442217,
0.00949372723698616,
0.019040580838918686,
-0.015024208463728428,
-0.008749954402446747,
0.024693254381418228,
-0.015024208463728428,
0.02031562104821205,
-0.0034426050260663033,
-0.003601985052227974,
0.00031278299866244197,
-0.018902452662587166,
0.012962895445525646,
0.015268591232597828,
-0.017478657886385918,
-0.01943371817469597,
0.0002990032662637532,
0.007644921075552702,
-0.0016880984185263515,
0.0008692843257449567,
0.00878183078020811,
-0.002219364745542407,
0.021505655720829964,
-0.04107750579714775,
-0.09001775085926056,
0.008712765760719776,
0.02958090230822563,
-0.03499981760978699,
0.005153282545506954,
-0.008022120222449303,
0.027987103909254074,
0.023991983383893967,
-0.037082381546497345,
-0.007273034658282995,
0.0530841201543808,
0.010550946928560734,
-0.003981840331107378,
0.007416476495563984,
0.02528827264904976,
0.028199611231684685,
-0.02479950711131096,
-0.0033443209249526262,
-0.027434587478637695,
0.002927276771515608,
0.0221856776624918,
-0.017340529710054398,
-0.004513106774538755,
0.043351322412490845,
-0.0037879282608628273,
0.0004074147727806121,
0.006917085964232683,
-0.020400622859597206,
0.03132345527410507,
-0.02877337858080864,
-0.010513758286833763,
-0.008255877532064915,
0.004345757886767387,
-0.04126875847578049,
0.02414073795080185,
0.021091269329190254,
-0.008553385734558105,
-0.004672486335039139,
0.035658590495586395,
0.047601453959941864,
-0.018764322623610497,
-0.05066154524683952,
0.021728787571191788,
0.05656922608613968,
-0.016575505957007408,
-0.0012830079067498446,
-0.034617308527231216,
-0.03499981760978699,
-0.00619987677782774,
-0.006407070439308882,
-0.007703360170125961,
-0.026733316481113434,
0.011857861652970314,
0.014928581193089485,
-0.00030846643494442105,
0.0048106154426932335,
-0.00325666181743145,
0.008117747493088245,
-0.022759445011615753,
-0.001164137152954936,
0.0023574938531965017,
-0.019975610077381134,
-0.028263362124562263,
-0.02968715690076351,
-0.009785924106836319,
-0.018509315326809883,
0.0016349718207493424,
-0.017128022387623787,
0.049173999577760696,
0.002725395606830716,
-0.002876806538552046,
0.002694847993552685,
-0.02100626565515995,
-0.009966554120182991,
-0.0016761448932811618,
-0.010402192361652851,
-0.0023880416993051767,
-0.021070018410682678,
-0.0034665120765566826,
-0.0232057087123394,
0.007182719185948372,
0.0013786358758807182,
-0.007267721928656101,
-0.06060685217380524,
0.013589790090918541,
0.03848492354154587,
-0.00004806298966286704,
0.010566885583102703,
0.035169824957847595,
0.01831805892288685,
0.002781178569421172,
-0.018966203555464745,
0.029517151415348053,
-0.010790016502141953,
0.019083082675933838,
-0.009174967184662819,
-0.019136209040880203,
0.00027692251023836434,
-0.02790210209786892,
-0.012495381757616997,
-0.019242461770772934,
-0.0464114174246788,
-0.007055215537548065,
-0.009982491843402386,
-0.01849868893623352,
-0.003062749747186899,
-0.001390589284710586,
-0.007512104231864214,
0.025840789079666138,
-0.06239190325140953,
0.0022286619059741497,
-0.01658613048493862,
-0.000355948373908177,
0.0017133335350081325,
0.03325726464390755,
0.01299477182328701,
0.013823547400534153,
-0.004446698352694511,
0.03699737787246704,
-0.02794460393488407,
0.029942164197564125,
0.02571328543126583,
-0.004691080655902624,
-0.025649532675743103,
0.017776167020201683,
0.02473575435578823,
-0.04124750941991806,
-0.008059308864176273,
-0.006842709146440029,
-0.018689945340156555,
0.017638038843870163,
-0.03162096440792084,
0.005673923064023256,
0.02484200894832611,
0.010115308687090874,
0.00006425000901799649,
0.04964151605963707,
-0.04751645028591156,
0.017861170694231987,
-0.005124062765389681,
-0.005902367644011974,
-0.0022751474753022194,
-0.005944869015365839,
-0.01582110859453678,
-0.008930585347115993,
-0.010226874612271786,
0.016437377780675888,
0.030643435195088387,
0.017999298870563507,
-0.027264581993222237,
-0.003649798920378089,
-0.026499558240175247,
0.009716859087347984,
0.006369881797581911,
-0.008208063431084156,
-0.018976829946041107,
0.02707332745194435,
0.014418565668165684,
-0.008479008451104164,
0.035722341388463974,
0.018349934369325638,
-0.020007485523819923,
-0.008601199835538864,
-0.01362166553735733,
0.009291846305131912,
-0.019901232793927193,
0.005487979855388403,
0.09103778004646301,
-0.015268591232597828,
0.0070074014365673065,
0.01577860675752163,
-0.00926528312265873,
-0.021016892045736313,
0.01574673131108284,
-0.00037354655796661973,
0.010843143798410892,
-0.01466294750571251,
0.03346977010369301,
-0.000739788229111582,
0.033979788422584534,
0.011549727991223335,
0.02992091327905655,
-0.00285289972089231,
0.013356032781302929,
0.03083469159901142,
-0.007984931580722332,
-0.019327465444803238,
0.0012278890935704112,
0.013887299224734306,
-0.0030813440680503845,
0.03298100829124451,
-0.02762584388256073,
0.005009840242564678,
-0.006093623582273722,
-0.0113372216001153,
-0.006168000865727663,
-0.012336001731455326,
0.008521510288119316,
0.00945653859525919,
0.033427271991968155,
-0.008351504802703857,
-0.006008620839565992,
-0.02577703632414341,
-0.006460197269916534,
-0.032513491809368134,
0.013834171928465366,
0.006045809481292963,
-0.006752393674105406,
0.024757005274295807,
0.0048823365941643715,
-0.01020562369376421,
0.016086740419268608,
0.012580384500324726,
-0.01790367253124714,
0.020124364644289017,
0.016607381403446198,
-0.018541190773248672,
-0.008542761206626892,
-0.014206058345735073,
0.01602298952639103,
-0.0304521806538105,
-0.02288694866001606,
-0.021335652098059654,
0.019763102754950523,
-0.005822677630931139,
-0.01362166553735733,
-0.03612610325217247,
-0.020368747413158417,
0.029984666034579277,
0.012707888148725033,
-0.01005155686289072,
0.014227309264242649
] | 2025-01-03 | 1 | 39750051 | [
"T cells",
"stem cell memory",
"adoptive cell therapy",
"better anti-tumor therapeutic effects",
"better anti-tumor effects",
"CAR-T cell therapy",
"tumor-specific T cells",
"stem cell memory and/or central memory",
"central memory phenotype",
"fully differentiated effector T cells",
"CAR-T cells",
"the stem cell memory",
"solid tumors",
"hematologic tumors",
"significant effects",
"improved therapeutic outcomes",
"immune checkpoint inhibitors",
"B-cell malignancies",
"revolutionary success",
"cancer patients",
"similar success",
"early differentiation stage",
"limited success",
"The anti-tumor effect",
"precursor phenotype",
"endogenous or adoptively transferred tumor-specific T cells",
"Cancer immunotherapy",
", adoptively transfered CAR-T cells",
"patients",
"optimized culture and expansion system"
] | [] | 0 | null | [
"Liu",
"Wang",
"Sun",
"Wang"
] | [
"Center for Cancer Immunotherapy, Institute of Biomedicine and Biotechnology, Chinese Academy of Sciences, Shenzhen 518055, China.",
"Center for Cancer Immunotherapy, Institute of Biomedicine and Biotechnology, Chinese Academy of Sciences, Shenzhen 518055; University of Chinese Academy of Sciences, Beijing 101408, China.",
"Center for Cancer Immunotherapy, Institute of Biomedicine and Biotechnology, Chinese Academy of Sciences, Shenzhen 518055, China.",
"Center for Cancer Immunotherapy, Institute of Biomedicine and Biotechnology, Chinese Academy of Sciences, Shenzhen 518055; University of Chinese Academy of Sciences, Beijing 101408; Laboratory of Human Environmental Epigenomes, Department of Biopharmaceutical Sciences, School of Pharmaceutical Science, Shenzhen University of Advanced Technology, Shenzhen 518107, China.*Corresponding author, E-mail: [email protected]."
] | [
"39750051"
] | [] | 9.66513 | 4.894483 |
39748414 | 84 | Lentivirus-based production of human chimeric antigen receptor macrophages from peripheral blood. | Although chimeric antigen receptor (CAR) T cell therapy has shown remarkable efficacy against leukemic cells, it still has critical limitations. CAR macrophage has been regarded as a potential alternative to CAR T cells. However, due to the difficulties in gene transduction into macrophages, the production of primary human CAR macrophages from peripheral blood mononuclear cells (PBMC) using lentivirus is highly challenging. Here, we report on how to generate CAR macrophages from human PBMC with lentiviral particles. Using our lentiviral protocol, we produced functional CAR macrophages to lyse and phagocytose target cancer cells efficiently. | [
0.05070195719599724,
0.00017627747729420662,
0.026704559102654457,
0.043085191398859024,
-0.06194356456398964,
-0.028081083670258522,
0.021427884697914124,
0.014430556446313858,
0.02109522558748722,
-0.025373918935656548,
0.0024619698524475098,
0.009945383295416832,
-0.042465753853321075,
0.02525920979678631,
0.014247019775211811,
-0.049096010625362396,
0.05088549107313156,
-0.02034960873425007,
0.05629981681704521,
0.04987604171037674,
0.049921926110982895,
0.01866336725652218,
0.014579679816961288,
0.04283282905817032,
-0.04014860838651657,
-0.027209283784031868,
0.00936036091297865,
0.0033782185055315495,
-0.020154600962996483,
-0.025419803336262703,
-0.011333378031849861,
-0.014843513257801533,
-0.01633474789559841,
-0.0030713684391230345,
0.010920421220362186,
0.016139740124344826,
0.03115531988441944,
0.003031219821423292,
-0.022357039153575897,
-0.0016690349439159036,
0.025626283138990402,
0.014315846376121044,
0.059006981551647186,
0.0862162634730339,
-0.041433364152908325,
-0.002188099082559347,
-0.018032459542155266,
-0.03044411540031433,
0.009744640439748764,
0.007112038787454367,
-0.05010545998811722,
0.0030799717642366886,
-0.027622241526842117,
0.02254057489335537,
-0.04230516031384468,
0.048499517142772675,
-0.05969524383544922,
-0.005924787372350693,
-0.027255168184638023,
0.039712708443403244,
0.02239145152270794,
-0.023745033890008926,
0.015371181070804596,
-0.01792922057211399,
-0.05272085592150688,
-0.021932611241936684,
-0.0657978281378746,
-0.021542595699429512,
0.011000717990100384,
0.05405149608850479,
-0.02254057489335537,
-0.021278761327266693,
0.004717461299151182,
0.0071636587381362915,
-0.004178322851657867,
0.009366096928715706,
0.005583524238318205,
0.029159359633922577,
-0.0015213454607874155,
0.035193122923374176,
0.04567764326930046,
-0.02115258015692234,
-0.013386692851781845,
-0.020452847704291344,
-0.006727759260684252,
-0.022643813863396645,
0.04659532755613327,
-0.03799205273389816,
-0.0360419787466526,
-0.03638610988855362,
-0.002691390458494425,
0.02369914948940277,
-0.05863991007208824,
0.019512223079800606,
-0.0341377854347229,
0.05354677140712738,
-0.0633200854063034,
-0.0316600427031517,
0.04932543262839317,
0.05781399458646774,
0.042259275913238525,
-0.004619957413524389,
0.004597015678882599,
-0.007456169929355383,
0.03292185813188553,
-0.003229095134884119,
-0.037143196910619736,
-0.004743271041661501,
0.02697986364364624,
0.02658984810113907,
0.08906108140945435,
-0.04241986945271492,
0.004023463930934668,
0.04005683958530426,
0.003057029563933611,
-0.034917816519737244,
-0.00415538065135479,
0.007272633258253336,
0.0004738969437312335,
0.007869127206504345,
-0.029870564118027687,
0.03436720743775368,
0.01639210246503353,
-0.0381067655980587,
0.009102262556552887,
-0.005202112253755331,
0.09369537979364395,
-0.022058792412281036,
-0.016082385554909706,
-0.018238939344882965,
0.04721476137638092,
-0.005454475060105324,
0.025809818878769875,
-0.0011951379710808396,
-0.023584438487887383,
0.010840123519301414,
-0.007547938264906406,
0.002008864190429449,
-0.036202572286129,
-0.010467315092682838,
0.01220517698675394,
-0.010645116679370403,
-0.00550896255299449,
0.009704492054879665,
-0.027255168184638023,
-0.027438705787062645,
-0.0021278762724250555,
0.015474420040845871,
0.002206739503890276,
0.03328892961144447,
-0.0016977125778794289,
0.018319236114621162,
0.04478290304541588,
-0.0017507660668343306,
-0.013661997392773628,
-0.045035265386104584,
0.006125530228018761,
0.05597862973809242,
-0.04836186394095421,
-0.017149191349744797,
-0.01787186600267887,
0.031086493283510208,
-0.05285850912332535,
-0.021427884697914124,
0.01409789640456438,
-0.000645245483610779,
-0.0019787526689469814,
0.029572317376732826,
-0.05395972728729248,
0.0027473117224872112,
-0.039345633238554,
-0.027369879186153412,
-0.030489999800920486,
-0.041754551231861115,
-0.062494173645973206,
-0.005038650240749121,
0.012686959467828274,
0.012308415956795216,
-0.03487193211913109,
-0.025901587679982185,
-0.00429590092971921,
0.056162167340517044,
0.05446445196866989,
0.0009033436654135585,
-0.02636042796075344,
0.01190693024545908,
-0.01768832840025425,
0.014029070734977722,
-0.0055777886882424355,
-0.018411004915833473,
0.01303109060972929,
0.004404875915497541,
0.05276674032211304,
0.011178519576787949,
0.008190316148102283,
0.015657957643270493,
0.032967742532491684,
0.007094832602888346,
0.006205827463418245,
-0.05437268689274788,
0.014614093117415905,
-0.004946881905198097,
-0.023997396230697632,
-0.011407939717173576,
-0.0157038401812315,
-0.03422955423593521,
0.0032807148527354,
0.030948840081691742,
-0.004522453993558884,
0.02553451433777809,
0.04636590555310249,
-0.014006128534674644,
0.0013664865400642157,
0.022942060604691505,
-0.03127003088593483,
-0.03913915529847145,
0.01834217831492424,
0.07066155225038528,
0.005689631216228008,
-0.01039848942309618,
-0.0019887899979948997,
0.0070776259526610374,
0.004040670581161976,
0.033862482756376266,
-0.04319990053772926,
-0.03159121796488762,
0.01190693024545908,
-0.04108923301100731,
0.0005846641142852604,
-0.003874340560287237,
0.042052797973155975,
0.03932269290089607,
0.0025551719591021538,
-0.04712299257516861,
0.0016460928600281477,
0.018009517341852188,
0.029801737517118454,
0.023561496287584305,
0.03466545417904854,
-0.014247019775211811,
0.00344991241581738,
0.03815264627337456,
-0.007811771705746651,
-0.006733494810760021,
-0.034504860639572144,
-0.008838429115712643,
-0.012147821485996246,
-0.07047801464796066,
0.028539923951029778,
-0.008895784616470337,
0.008058398962020874,
-0.010203481651842594,
-0.038565605878829956,
0.006773643661290407,
-0.0024504989851266146,
0.06529310345649719,
0.011471030302345753,
-0.006165679078549147,
0.014774687588214874,
-0.03624845668673515,
0.001636055763810873,
0.005322558339685202,
-0.061163533478975296,
-0.016013558954000473,
-0.00779456552118063,
-0.02197849377989769,
-0.045241743326187134,
0.01359317172318697,
0.016082385554909706,
0.01205605361610651,
0.018858375027775764,
-0.014476440846920013,
0.05102314427495003,
-0.0015586263034492731,
-0.04882070794701576,
0.012469010427594185,
0.018617482855916023,
0.03221065551042557,
-0.031751811504364014,
0.033472467213869095,
-0.031247086822986603,
0.037877343595027924,
-0.01701153814792633,
0.01644945703446865,
0.0002310337295057252,
-0.017676858231425285,
0.06469660997390747,
0.0010323927272111177,
0.008408265188336372,
-0.04147924855351448,
0.00389441498555243,
-0.0035072676837444305,
-0.013707881793379784,
-0.016369160264730453,
-0.006010820157825947,
0.005239393096417189,
-0.02555745653808117,
-0.0014561039861291647,
-0.026750443503260612,
-0.0007470508571714163,
0.0016303202137351036,
0.010111713781952858,
-0.014373200945556164,
-0.04845363274216652,
-0.03420661389827728,
0.0047203293070197105,
0.0005369876162149012,
-0.024387411773204803,
0.023653265088796616,
0.05428091809153557,
0.0324859581887722,
0.009280064143240452,
0.02594747208058834,
0.004453627858310938,
0.013008148409426212,
0.012446068227291107,
0.01451085414737463,
-0.09470482915639877,
0.02638337016105652,
-0.06313655525445938,
-0.0752958431839943,
-0.0043647270649671555,
-0.007255427073687315,
-0.0048780557699501514,
-0.008723719045519829,
-0.03005409985780716,
0.007370137143880129,
-0.03225653991103172,
0.012790199369192123,
-0.027714010328054428,
0.031086493283510208,
-0.01905338279902935,
0.04565470293164253,
-0.017401553690433502,
-0.015657957643270493,
-0.034688398241996765,
-0.0192598607391119,
-0.04565470293164253,
-0.01024936605244875,
-0.0034728546161204576,
0.013237569481134415,
0.010329662822186947,
0.016587110236287117,
0.039919186383485794,
-0.011207196861505508,
0.018881317228078842,
0.019718701019883156,
0.039093270897865295,
0.030902955681085587,
-0.0008674967102706432,
-0.02482330985367298,
0.03026057966053486,
0.02088874764740467,
-0.0029623936861753464,
-0.0056724245660007,
0.04535645619034767,
-0.008213258348405361,
0.00689982483163476,
0.015256471000611782,
-0.007828978821635246,
0.026498081162571907,
0.03303656727075577,
-0.06584371626377106,
0.01730978488922119,
0.05423503369092941,
0.04918777942657471,
-0.012354300357401371,
0.032141827046871185,
0.0015485890908166766,
-0.025718050077557564,
-0.033587176352739334,
-0.024777425453066826,
-0.00022350586368702352,
0.01420113630592823,
-0.002487779827788472,
0.024364469572901726,
0.03845089301466942,
0.00595346512272954,
0.030696477741003036,
-0.002591019030660391,
0.04576941207051277,
-0.029457606375217438,
-0.01272137276828289,
-0.021221406757831573,
-0.01772274263203144,
0.026039239019155502,
-0.0021278762724250555,
0.010593497194349766,
-0.0401715487241745,
0.03968976438045502,
0.015153231099247932,
-0.01425849087536335,
0.012457539327442646,
-0.00389441498555243,
-0.04049273952841759,
0.05818106606602669,
-0.0228961780667305,
0.062815360724926,
0.03845089301466942,
0.03085707314312458,
-0.0012037412961944938,
-0.0034470446407794952,
-0.011711922474205494,
-0.0210378710180521,
0.0478571392595768,
-0.019477810710668564,
0.015107347629964352,
0.023469729349017143,
-0.009383303113281727,
-0.006808056496083736,
0.01978752762079239,
-0.015910319983959198,
0.02576393447816372,
0.026521023362874985,
0.04978427290916443,
-0.009366096928715706,
-0.0027645183727145195,
0.04781125485897064,
-0.002988203428685665,
0.02555745653808117,
0.033380698412656784,
-0.044920556247234344,
0.002618262777104974,
-0.0025852834805846214,
0.013971715234220028,
0.006779379211366177,
0.028448155149817467,
0.0418233759701252,
-0.005190641153603792,
-0.022942060604691505,
-0.016759175807237625,
0.0007294858805835247,
0.012480481527745724,
-0.009406245313584805,
0.013616112992167473,
0.036822009831666946,
-0.04432406276464462,
-0.016701821237802505,
-0.02254057489335537,
0.06781673431396484,
-0.006354950834065676,
0.02079697884619236,
0.012962264940142632,
-0.019867824390530586,
0.00017376818868797272,
0.03271538019180298,
0.00297673256136477,
0.020257839933037758,
-0.03608786314725876,
-0.010409960523247719,
-0.01943192631006241,
-0.02073962427675724,
-0.01511881873011589,
-0.023767976090312004,
0.013707881793379784,
-0.023836800828576088,
0.012124879285693169,
-0.04129571095108986,
0.006045232992619276,
-0.012491952627897263,
0.04046979546546936,
-0.012342829257249832,
0.015164702199399471,
-0.013226098380982876,
-0.026291601359844208,
0.03824441507458687,
0.03679906576871872,
-0.023435315117239952,
0.023951511830091476,
-0.024180931970477104,
0.0372808501124382,
0.003791175549849868,
-0.020303724333643913,
0.04629708081483841,
-0.033059511333703995,
0.024341527372598648,
0.026842212304472923,
-0.012182234786450863,
0.015451477840542793,
0.001515609910711646,
0.00812148954719305,
-0.03631728142499924,
-0.014120838604867458,
-0.01318021398037672,
0.0018382326234132051,
0.06547664105892181,
-0.0009076452697627246,
-0.0027071633376181126,
-0.030375288799405098,
0.029801737517118454,
-0.005259467754513025,
0.01496969535946846,
-0.0073930793441832066,
-0.009606988169252872,
0.01180369034409523,
-0.017734212800860405,
-0.020131658762693405,
0.006022291257977486,
0.006504074204713106,
0.00360477133654058,
-0.01662152260541916,
0.04790302366018295,
-0.00996832549571991,
0.011356320232152939,
0.05648335441946983,
0.04035508632659912,
0.023056771606206894,
0.06758731603622437,
-0.025121556594967842,
0.031545333564281464,
-0.041731610894203186,
-0.023114126175642014,
0.030398230999708176,
-0.017596561461687088,
-0.017711270600557327,
-0.021932611241936684,
-0.059741128236055374,
-0.018319236114621162,
-0.024043280631303787,
0.0018324971897527575,
0.0029423192609101534,
-0.043383438140153885,
-0.007874862290918827,
0.004837907385081053,
-0.0004914619494229555,
0.00017385781393386424,
-0.02523626759648323,
-0.06382481753826141,
-0.013363750651478767,
-0.04682474583387375,
0.01778009720146656,
-0.009859350509941578,
0.003283582627773285,
-0.006945709232240915,
-0.02525920979678631,
-0.02798931486904621,
-0.04044685512781143,
0.022827351465821266,
0.00825340673327446,
-0.03179769590497017,
0.013065503910183907,
0.007674119435250759,
0.022563517093658447,
-0.023171482607722282,
-0.010788504034280777,
-0.017401553690433502,
0.013432577252388,
-0.020039889961481094,
0.01751626469194889,
-0.005167699418962002,
0.027920488268136978,
-0.013478460721671581,
0.003900150302797556,
-0.011218667961657047,
0.02585570327937603,
-0.023148540407419205,
-0.007742945570498705,
-0.01605944335460663,
-0.010105977766215801,
-0.04230516031384468,
-0.02750753052532673,
0.018009517341852188,
0.03617963194847107,
-0.00040650463779456913,
-0.024479178711771965,
0.035216063261032104,
0.0017894807970151305,
-0.0026326014194637537,
-0.013008148409426212,
0.01482057198882103,
-0.0017980840057134628,
0.011241610161960125,
0.038565605878829956,
-0.046755921095609665,
0.04886658862233162,
0.017975104972720146,
-0.015841493383049965,
0.010691000148653984,
0.004774816334247589,
0.022207915782928467,
-0.013788178563117981,
-0.02922818623483181,
0.0029853356536477804,
0.02034960873425007,
-0.015153231099247932,
0.013753765262663364,
-0.05253732204437256,
-0.016759175807237625,
-0.012400183826684952,
-0.006332009099423885,
0.02493802085518837,
0.006618784740567207,
0.02647513896226883,
0.014373200945556164,
-0.04599883407354355,
0.004631428513675928,
0.003578961594030261,
0.003733820514753461,
-0.01843394711613655,
-0.007524996064603329,
-0.010358341038227081,
0.019489280879497528,
-0.026865154504776,
-0.05161963775753975,
-0.008781073614954948,
0.022150559350848198,
-0.022678228095173836,
0.010358341038227081,
0.0028777949046343565,
-0.03328892961144447,
0.06231063976883888,
0.03927680850028992,
-0.029182301834225655,
0.002548002637922764,
0.01946633867919445,
0.027645183727145195,
-0.0037854399997740984,
0.009303005412220955,
0.007198071572929621,
-0.03478016331791878,
0.0029968067537993193,
-0.0035646227188408375,
-0.01958104968070984,
-0.005999349057674408,
-0.014992636628448963,
-0.05194082483649254,
-0.02461683191359043,
-0.0019343025051057339,
-0.013673468492925167,
-0.021141109988093376,
-0.019489280879497528,
-0.030742362141609192,
0.015371181070804596,
0.01783745177090168,
0.025511572137475014,
-0.010404224507510662,
-0.008041192777454853,
-0.010473051108419895,
-0.005830151494592428,
0.0071235098876059055,
-0.011614418588578701,
0.03478016331791878,
-0.0055204336531460285,
-0.046664152294397354,
0.01517617329955101,
-0.003710878314450383,
-0.03216477110981941,
-0.01733272708952427,
0.018950141966342926,
-0.024570947512984276,
0.02709457464516163,
-0.009647136554121971,
0.003670729696750641,
-0.04157101362943649,
0.009647136554121971,
-0.02298794500529766,
-0.00933168362826109,
-0.005896109621971846,
0.06272359192371368,
0.06478837877511978,
-0.020900217816233635,
0.02544274553656578,
0.013616112992167473,
0.0001085267067537643,
-0.02381386049091816,
0.022861763834953308,
-0.015084405429661274,
0.017585089430212975,
0.0009291534661315382,
0.0033007890451699495,
0.07364401966333389,
0.030811188742518425,
-0.01689682900905609,
-0.05056430399417877,
-0.04698534309864044,
0.032761264592409134,
0.0067507014609873295,
-0.029985273256897926,
0.017470380291342735,
0.0011793653247877955,
0.016644464805722237,
0.0211181677877903,
-0.03952917084097862,
-0.041548073291778564,
0.04046979546546936,
0.00914241187274456,
0.013581700623035431,
-0.005804341286420822,
-0.014579679816961288,
-0.01533676777034998,
-0.01997106522321701,
-0.025419803336262703,
-0.033770713955163956,
0.0035818293690681458,
0.03845089301466942,
0.03138474002480507,
0.013111388310790062,
0.02615395002067089,
-0.007112038787454367,
-0.03535371646285057,
0.013294924050569534,
0.004032067488878965,
0.0429016537964344,
-0.0002894642821047455,
0.019420454278588295,
-0.01502704992890358,
-0.05235378444194794,
-0.007312782108783722,
-0.007915010675787926,
0.018617482855916023,
0.01656416803598404,
0.029778795316815376,
-0.00949801318347454,
-0.028471097350120544,
0.012101937085390091,
0.008717983029782772,
0.01220517698675394,
0.03381659835577011,
0.01363905519247055,
0.030306462198495865,
0.005936258472502232,
0.027255168184638023,
-0.02617689222097397,
-0.006865411996841431,
0.016518283635377884,
0.007312782108783722,
-0.0017106174491345882,
0.0401715487241745,
-0.003920224495232105,
0.002515023574233055,
-0.014843513257801533,
-0.036019034683704376,
-0.01067952997982502,
0.01205605361610651,
0.007863391190767288,
0.03679906576871872,
-0.03679906576871872,
0.0020848598796874285,
-0.033770713955163956,
-0.019386041909456253,
0.0017593692755326629,
-0.03237124904990196,
-0.020751094445586205,
0.009090791456401348,
-0.021875254809856415,
0.016162682324647903,
0.06134707108139992,
0.00048680187319405377,
-0.021577008068561554,
-0.021967023611068726,
-0.017917750403285027,
0.007278368808329105,
-0.0059477295726537704,
0.01677064597606659,
0.0007764453766867518,
-0.033449526876211166,
0.007691326085478067,
0.011012189090251923,
-0.030214695259928703,
-0.04560881853103638,
-0.01451085414737463,
-0.014086425304412842,
0.0037080105394124985,
-0.027943430468440056,
0.0037194816395640373,
0.012354300357401371,
0.038290299475193024,
-0.007817507721483707,
-0.0003885811602231115,
0.0004828586825169623,
-0.0013621848775073886,
0.004356123972684145,
0.024869194254279137,
-0.007897804491221905,
-0.0014912339393049479,
0.013375221751630306,
-0.016965653747320175,
0.017137719318270683,
0.0034126315731555223,
0.01639210246503353,
-0.011706186458468437,
0.010616438463330269,
-0.0198792964220047,
-0.013719352893531322,
-0.005156228318810463,
-0.02236850932240486,
-0.005678160116076469,
0.01251489482820034,
-0.01164309587329626,
-0.030994724482297897,
-0.026704559102654457,
0.024043280631303787,
0.008379587903618813,
0.013845534063875675,
-0.03422955423593521,
0.032348304986953735,
0.03464251384139061,
-0.06524722278118134,
-0.015508833341300488,
-0.008224728517234325,
0.015772666782140732,
-0.01946633867919445,
0.00953816156834364,
-0.02984762191772461,
-0.017114777117967606,
0.016873886808753014,
0.0032663759775459766,
0.010157597251236439,
-0.027163401246070862,
0.02544274553656578,
0.005173434969037771,
0.01822746731340885,
-0.025213325396180153,
-0.02328619174659252,
-0.07781947404146194,
-0.016025029122829437,
0.03390836715698242,
-0.021944081410765648,
0.02484625205397606,
0.013432577252388,
0.04914189502596855,
0.0028190058656036854,
0.022529104724526405,
-0.02523626759648323,
0.022655285894870758,
-0.07524996250867844,
-0.009475070983171463,
0.029709968715906143,
0.008333703503012657,
-0.04872893914580345,
0.014797629788517952,
-0.026039239019155502,
-0.0061370013281702995,
0.042557522654533386,
-0.0324859581887722,
-0.02645219676196575,
-0.006544223055243492,
0.005313954781740904,
0.0037080105394124985,
0.0022053057327866554,
0.01866336725652218,
-0.0006975820288062096,
0.04228221997618675,
-0.018181582912802696,
0.010404224507510662,
0.0006846771575510502,
0.010214952751994133,
-0.0098364083096385,
-0.03636316582560539,
-0.01984488219022751,
0.018835432827472687,
0.0044937762431800365,
-0.02431858517229557,
-0.01828482374548912,
0.022643813863396645,
0.02162289246916771,
0.03195829316973686,
-0.02870051935315132,
0.04014860838651657,
0.023022359237074852,
-0.04712299257516861,
-0.02369914948940277,
-0.0297558531165123,
-0.010209217667579651,
0.030902955681085587,
-0.02902170829474926,
-0.024157989770174026,
-0.04712299257516861,
0.030788246542215347,
0.0002926905290223658,
0.05877755954861641,
0.0015356842195615172,
0.021427884697914124,
-0.03310539573431015,
0.013042561709880829,
-0.007106303703039885,
-0.022379981353878975,
-0.01854865625500679,
-0.047994792461395264,
0.019179563969373703,
-0.010071564465761185,
-0.03801499679684639,
-0.01409789640456438,
0.019810469821095467,
-0.017757155001163483,
0.01922544650733471,
0.010094506666064262,
-0.009096527472138405,
-0.020716682076454163,
-0.01757361926138401,
0.010352605022490025,
-0.004026331938803196,
-0.017298314720392227,
-0.049508966505527496,
0.0019300009589642286,
0.013065503910183907,
-0.010105977766215801,
0.025213325396180153,
-0.010283779352903366,
-0.005669557023793459,
-0.0653848722577095,
-0.026727501302957535,
-0.036936718970537186,
0.022288212552666664,
-0.004855113569647074,
0.0032147562596946955,
-0.026842212304472923,
0.040332142263650894,
0.0005896826623938978,
-0.007892069406807423,
-0.014315846376121044,
-0.005738383159041405,
0.021278761327266693,
0.0385197214782238,
0.03473427891731262,
-0.0018382326234132051,
0.01174633577466011,
0.04411758482456207,
0.004379066172987223,
-0.000843120738863945,
-0.037464387714862823,
0.005583524238318205,
-0.002020335290580988,
-0.005144757218658924,
-0.006796585861593485,
0.011511179618537426,
0.0016977125778794289,
0.029503490775823593,
-0.01287049613893032,
0.011327642947435379,
0.00414104200899601,
-0.013983186334371567,
0.01822746731340885,
0.007880598306655884,
0.020521674305200577,
-0.010042887181043625,
0.02293059043586254,
-0.02656690776348114,
-0.00214508268982172,
0.008436943404376507,
-0.01205605361610651,
0.012549307197332382,
-0.006853940896689892,
-0.02840227261185646,
0.025167440995573997,
-0.006653197575360537,
0.016644464805722237,
-0.012457539327442646,
0.04049273952841759,
0.015657957643270493,
0.06570606678724289,
-0.020751094445586205,
0.01272137276828289,
0.034917816519737244,
-0.027622241526842117,
-0.025901587679982185,
-0.0062345052137970924,
-0.004789155442267656,
0.058410488069057465,
-0.00021293100144248456,
-0.021989965811371803,
-0.0035760938189923763,
0.0061771501787006855,
-0.00344991241581738,
0.0143617307767272,
0.033564236015081406,
0.015635015442967415,
0.02156553789973259,
-0.04425523802638054,
0.04416346922516823,
-0.015084405429661274,
-0.026039239019155502,
0.016529755666851997,
0.06676139682531357,
0.010272308252751827,
0.004525321535766125,
0.0027258037589490414,
-0.017699800431728363,
-0.0032921857200562954,
0.016105327755212784,
0.02759929932653904,
0.006808056496083736,
-0.04918777942657471,
0.04258046671748161,
-0.027255168184638023,
-0.002001694869250059,
0.0030054100789129734,
-0.010754091665148735,
-0.0027387086302042007,
0.023228837177157402,
0.051252566277980804,
0.02626866102218628,
-0.010300985537469387,
-0.026085123419761658,
0.019776057451963425,
-0.02911347523331642,
-0.019535165280103683,
-0.02585570327937603,
0.04035508632659912,
0.023630322888493538,
-0.03812970593571663,
-0.028035199269652367,
0.013845534063875675,
-0.004152513109147549,
-0.007542202714830637,
0.007169394288212061,
0.042878713458776474,
-0.0034871932584792376,
0.017711270600557327,
-0.05487741157412529,
0.023125598207116127,
-0.0020461450330913067,
-0.009280064143240452,
0.020154600962996483,
0.0032921857200562954,
0.012216647155582905,
-0.02964114397764206,
-0.04485173150897026,
0.002125008497387171,
-0.008414001204073429,
-0.002456234535202384,
-0.04102040454745293,
0.008482826873660088,
0.05597862973809242,
0.008167373947799206,
-0.011121164076030254,
-0.0005391384474933147,
-0.0005305351805873215,
-0.0015844361623749137,
0.028884055092930794,
-0.008207522332668304,
-0.022104676812887192,
0.002087727654725313,
-0.03361012041568756,
-0.022081734612584114,
-0.014694389887154102,
-0.02922818623483181,
0.05253732204437256,
0.01344404835253954,
0.008333703503012657,
-0.01922544650733471,
0.012446068227291107,
0.014682918787002563,
0.03191240876913071,
-0.03523900732398033,
-0.00628612469881773,
0.0030943104065954685,
-0.007312782108783722,
-0.03117826208472252,
0.019156621769070625,
0.02668161690235138,
0.07093685120344162,
0.011998698115348816,
-0.0014826307306066155,
0.012090465985238552,
0.037143196910619736,
0.003111517056822777,
0.022081734612584114,
0.0042672231793403625,
0.011883988045156002,
-0.014923810958862305,
0.02707163244485855,
-0.0022210783790796995,
-0.013547287322580814,
-0.020877275615930557,
-0.0039804475381970406,
0.025993354618549347,
0.026498081162571907,
0.0426492914557457,
0.0010323927272111177,
0.00674496591091156,
-0.016231508925557137,
-0.0418233759701252,
0.057584572583436966,
0.0019414719427004457,
-0.020246369764208794,
0.002591019030660391,
-0.04108923301100731,
0.01195281371474266,
-0.03996507078409195,
0.005474549252539873,
0.01486645545810461,
0.015910319983959198,
-0.0272781103849411,
0.012446068227291107,
0.0037194816395640373,
-0.027369879186153412,
-0.028975823894143105,
-0.01116704847663641,
-0.010272308252751827,
-0.03287597373127937,
-0.026704559102654457,
-0.027025748044252396,
0.017860393971204758,
0.023423844948410988,
-0.02952643297612667,
-0.019236918538808823,
0.023561496287584305,
0.027736952528357506,
-0.014992636628448963,
-0.045127034187316895,
0.024157989770174026,
-0.0274845901876688,
-0.025282151997089386,
-0.03718908131122589,
0.04597589001059532,
0.0031918142922222614,
-0.02870051935315132,
-0.01195281371474266,
0.001994525548070669,
-0.016162682324647903,
0.015359709970653057,
-0.0013033958384767175,
-0.02555745653808117,
0.007008799817413092,
0.004703122656792402,
0.007295575458556414,
-0.013604641892015934,
-0.013019619509577751,
-0.007702797185629606,
-0.009274328127503395,
-0.022552046924829483,
-0.016885356977581978,
-0.00962993036955595,
-0.01878954842686653,
-0.004003389738500118,
-0.004794890992343426,
0.024043280631303787,
-0.001002281322143972,
0.008391059003770351,
-0.00021830805053468794,
0.00797236617654562,
-0.007978102192282677,
0.006515545304864645,
-0.012159292586147785,
0.007576615549623966,
0.01511881873011589,
-0.006349215283989906,
0.028654634952545166,
0.016174152493476868,
0.022139089182019234,
-0.006073910742998123,
0.003997654188424349,
0.01220517698675394,
-0.010541876778006554,
-0.025167440995573997,
0.018537186086177826,
0.051849059760570526,
-0.03815264627337456,
-0.011522650718688965,
0.056988079100847244,
-0.015554717741906643,
-0.01334080845117569,
0.02349267154932022,
0.010450108908116817,
0.010174804367125034,
-0.010083035565912724,
-0.016518283635377884,
0.020521674305200577,
0.030489999800920486,
-0.0011349150445312262,
-0.007978102192282677,
0.036638472229242325,
-0.014682918787002563,
-0.027828719466924667,
-0.0068367342464625835,
-0.023171482607722282,
0.007742945570498705,
0.0015442875446751714,
-0.029274070635437965,
-0.011826632544398308,
0.004763345699757338,
0.01866336725652218,
0.01137352641671896,
0.029870564118027687,
0.0030885750893503428,
0.004995633848011494,
0.007955159991979599,
-0.02017754316329956,
-0.02032666653394699,
-0.030696477741003036,
-0.011815161444246769,
-0.024089165031909943,
-0.010748355649411678,
-0.04478290304541588,
0.005638011731207371,
0.00036886532325297594,
0.024685658514499664,
-0.003186078742146492,
-0.006997328717261553,
0.012159292586147785,
-0.014579679816961288,
-0.009274328127503395,
0.014040541835129261,
0.007599557749927044,
-0.008155902847647667,
-0.016139740124344826,
-0.047077108174562454,
0.0012575117871165276,
0.005787135101854801,
0.0029738647863268852,
0.007066154852509499,
0.03271538019180298,
-0.017825981602072716,
-0.0013586002169176936,
0.013765236362814903,
0.01706889271736145,
0.019156621769070625,
-0.0027329730801284313,
-0.04813244566321373,
-0.016254451125860214,
0.0024834780488163233,
0.01830776408314705,
0.021634364500641823,
-0.010685265064239502,
-0.03136179596185684,
0.015508833341300488,
-0.013008148409426212,
-0.009991267696022987,
-0.01819305494427681,
-0.0030369553714990616,
-0.008345174603164196,
-0.025488629937171936,
0.022586459293961525,
-0.027736952528357506,
-0.03932269290089607,
0.011666038073599339,
-0.02310265600681305,
-0.010450108908116817,
0.005867432337254286,
-0.028264619410037994,
-0.037464387714862823,
-0.00011363489466020837,
-0.0274845901876688,
0.021313175559043884,
0.0033007890451699495,
0.011591476388275623,
0.0015586263034492731,
-0.03741850331425667,
0.04923366382718086,
0.01583002135157585,
-0.003670729696750641,
-0.008826958015561104,
0.005454475060105324,
-0.01297373604029417,
0.009974061511456966,
0.05253732204437256,
-0.006922767031937838,
0.02739282138645649,
-0.03505546972155571,
-0.011086750775575638,
-0.03631728142499924,
0.03709731251001358,
-0.019982535392045975,
-0.01650681346654892,
-0.024662716314196587,
0.030398230999708176,
-0.03441309183835983,
0.0032319629099220037,
0.002808968536555767,
0.019649876281619072,
0.021840842440724373,
-0.006641726940870285,
0.004872320219874382,
0.02390562742948532,
-0.01465997751802206,
0.0013277718098834157,
0.031820639967918396,
0.0405845046043396,
0.03445897623896599,
0.01318021398037672,
0.015543246641755104,
-0.017527734860777855,
0.043268729001283646,
0.02638337016105652,
0.025098614394664764,
-0.034803107380867004,
-0.011769277043640614,
-0.0034527801908552647,
-0.02139347232878208,
-0.011729128658771515,
0.01011744886636734,
0.042259275913238525,
-0.01266401819884777,
-0.028448155149817467,
0.04384227842092514,
-0.02254057489335537,
0.008006779477000237,
-0.015692370012402534,
0.008534446358680725,
-0.0018669102573767304,
-0.0025766801554709673,
-0.009239914827048779,
0.0067507014609873295,
0.0014353126753121614,
-0.03443603217601776,
-0.0024763087276369333,
-0.016885356977581978,
0.004545395728200674,
0.012836082838475704,
-0.014430556446313858,
-0.0013033958384767175,
-0.01211340818554163,
-0.0426492914557457,
-0.052583202719688416,
0.01180369034409523,
0.01691976934671402,
-0.006010820157825947,
-0.004055009223520756,
-0.007691326085478067,
0.004499511793255806,
0.03507841005921364,
-0.036638472229242325,
-0.020429905503988266,
0.05221613124012947,
0.004040670581161976,
-0.005422929767519236,
-0.027438705787062645,
0.03636316582560539,
-0.0014087859308347106,
-0.016323275864124298,
0.007834713906049728,
-0.03606491908431053,
-0.005273806396871805,
0.03416072949767113,
-0.01807834394276142,
-0.006658933125436306,
0.02656690776348114,
0.008654892444610596,
-0.003163136774674058,
-0.025190383195877075,
-0.036523763090372086,
0.040400970727205276,
-0.02061344124376774,
-0.0005190641386434436,
-0.041731610894203186,
-0.00800104346126318,
-0.021554065868258476,
0.022999417036771774,
0.022643813863396645,
-0.00283621228300035,
0.0012804537545889616,
0.013054032810032368,
0.0168624147772789,
-0.022081734612584114,
0.0018511376110836864,
0.02422681637108326,
0.020579028874635696,
-0.0058072092942893505,
-0.04106628894805908,
0.026429254561662674,
-0.00829929020255804,
-0.029205244034528732,
0.014694389887154102,
-0.013581700623035431,
-0.03794616833329201,
0.0073644015938043594,
0.027714010328054428,
-0.03374777361750603,
0.00031061400659382343,
0.0430622473359108,
0.01766538806259632,
0.0131228594109416,
-0.04115805774927139,
-0.024043280631303787,
-0.031935349106788635,
0.005844490136951208,
0.020831391215324402,
-0.005276673939079046,
0.0031487978994846344,
0.01813569851219654,
-0.03273832052946091,
0.011539856903254986,
0.008046927861869335,
-0.007232484873384237,
-0.004792022984474897,
0.023091183975338936,
-0.02431858517229557,
0.007892069406807423,
-0.013558758422732353,
0.018502771854400635,
-0.014854984357953072,
-0.007949423976242542,
-0.04085981100797653,
0.012319887056946754,
-0.006446719169616699,
0.012331358157098293,
-0.032853033393621445,
0.010966305620968342,
0.011545591987669468,
-0.0060911173932254314,
-0.0031602689996361732,
0.022460278123617172,
0.006939973682165146,
-0.0049210721626877785,
-0.04361286014318466,
-0.0036735974717885256,
-0.005970671307295561,
-0.0019127943087369204,
-0.017401553690433502,
-0.0008165939943864942,
-0.02216203138232231,
-0.009280064143240452,
0.005124683026224375,
-0.04602177441120148,
-0.03946034610271454,
-0.001320602372288704,
-0.006400835234671831,
0.005744118709117174,
0.003544548526406288,
-0.0022942060604691505,
0.028654634952545166,
0.027232225984334946,
-0.03129297122359276,
0.010777032934129238,
0.007243955973535776,
0.0031401945743709803,
0.04469113424420357,
0.03737261891365051,
0.004582676570862532,
0.009824938140809536,
-0.0019687155727297068,
0.019867824390530586,
-0.022001435980200768,
-0.003100045956671238,
0.03273832052946091,
-0.03200417384505272,
-0.004625692963600159,
0.03319716081023216,
-0.012090465985238552,
-0.02709457464516163,
0.0003839210548903793,
-0.024915078654885292,
0.01480910088866949,
0.008804015815258026,
-0.03526194766163826,
0.010065829381346703,
-0.0157038401812315,
0.0010847293306142092,
0.0038886794354766607,
0.012996677309274673,
-0.0058272834867239,
0.020005477592349052,
-0.027553414925932884,
0.008218993432819843,
0.019867824390530586,
-0.02493802085518837,
-0.01612826995551586,
0.05106902867555618,
-0.01641504466533661,
0.014637035317718983,
0.028333446010947227,
-0.0007814639830030501,
-0.017447438091039658,
0.03280714899301529,
-0.016931241378188133,
0.006395099684596062,
0.02390562742948532,
-0.021485241129994392,
-0.004814965184777975,
0.02759929932653904,
0.008500033989548683,
0.0029709970112890005,
0.012446068227291107,
0.009130940772593021,
-0.02636042796075344,
0.009423451498150826,
-0.0420757420361042,
0.011700451374053955,
-0.01456820871680975,
0.034504860639572144,
0.08598684519529343,
-0.02216203138232231,
0.01680506020784378,
0.014533795416355133,
0.033380698412656784,
-0.02553451433777809,
0.014132309705018997,
0.007857656106352806,
0.00735866604372859,
-0.0143617307767272,
0.02461683191359043,
0.0006542071932926774,
0.025718050077557564,
-0.004522453993558884,
0.0316600427031517,
-0.014786158688366413,
0.019982535392045975,
0.03266949579119682,
0.006377893034368753,
-0.03218771144747734,
-0.024089165031909943,
0.013478460721671581,
-0.019546635448932648,
0.020108716562390327,
-0.030880015343427658,
-0.023125598207116127,
0.00732998875901103,
0.017470380291342735,
-0.0337248295545578,
-0.009641401469707489,
0.011367791332304478,
-0.00797236617654562,
-0.011264552362263203,
-0.02360738068819046,
-0.015290883369743824,
-0.013352279551327229,
-0.025901587679982185,
-0.0028591544833034277,
-0.0010546179255470634,
-0.005695366766303778,
0.011384997516870499,
0.022471748292446136,
-0.0010194878559559584,
0.017757155001163483,
0.016070913523435593,
-0.002472007181495428,
-0.02606218121945858,
-0.0024031808134168386,
0.0041238353587687016,
-0.03978153318166733,
0.016380632296204567,
-0.028998766094446182,
0.03457368537783623,
-0.0060911173932254314,
-0.01542853657156229,
-0.01854865625500679,
-0.025373918935656548,
0.028975823894143105,
-0.005735515151172876,
-0.03147650882601738,
-0.005609333980828524,
0.025098614394664764,
0.008161637932062149,
0.02842521481215954,
0.008758132345974445
] | 2025-01-03 | 13 | 39748414 | [
"CAR T cells",
"CAR macrophage",
"CAR macrophages",
"functional CAR macrophages",
"primary human CAR macrophages",
"T cell therapy",
"peripheral blood mononuclear cells",
"leukemic cells",
"macrophages",
"target cancer cells",
"human PBMC",
"CAR",
"remarkable efficacy",
"PBMC",
"chimeric antigen receptor",
"lentiviral particles",
"gene transduction",
"critical limitations",
"lyse",
"lentivirus",
"our lentiviral protocol",
"a potential alternative",
"the production",
"the difficulties",
"it",
"we"
] | [
"CAR macrophages",
"Human PBMC",
"Lentivirus",
"Primary human macrophages"
] | 0 | 10.1186/s40364-024-00703-9 | [
"Choi",
"Kim",
"Lee",
"Park",
"Jeun",
"Lee",
"Park"
] | [
"Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.",
"Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.",
"Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.",
"Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.",
"Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.\nCollege of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.",
"Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.",
"Bio & Drug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. [email protected].\nMedicinal Chemistry and Pharmacology, Korea University of Science and Technology, Daejeon, Republic of Korea. [email protected]."
] | [
"39748414",
"33312759",
"37680942",
"37321663",
"25035953",
"18451984",
"35921473",
"36978075",
"38012418",
"36638788",
"34510559",
"16397508",
"32361713"
] | [] | 10.312987 | 5.428725 |
39747430 | 85 | Antigen experience history directs distinct functional states of CD8 | Although chimeric antigen receptor (CAR) T cells are effective against B-lineage malignancies, post-CAR relapse is common, and efficacy in other tumors is limited. These challenges may be addressed through rational manipulations to control CAR T cell function. Here we examine the impact of cognate T cell antigen experience on subsequent CD8 | [
0.024174805730581284,
0.02044229581952095,
0.051068659871816635,
0.04301039129495621,
-0.02113441564142704,
-0.03673186153173447,
0.007013907190412283,
0.024298399686813354,
-0.029340997338294983,
0.011376743204891682,
0.007749286014586687,
-0.0020485552959144115,
-0.04466653987765312,
0.022926516830921173,
0.006995368283241987,
-0.044790130108594894,
0.054380953311920166,
-0.025077035650610924,
0.026720823720097542,
0.0352981835603714,
0.022716408595442772,
-0.000558486208319664,
-0.002576915780082345,
0.016895173117518425,
-0.04449350759387016,
0.0012730087619274855,
0.023223139345645905,
0.014386234804987907,
0.005657473113387823,
-0.013854783959686756,
0.018403008580207825,
-0.0286241564899683,
-0.03898125886917114,
-0.031738702207803726,
-0.01661090925335884,
0.0495113879442215,
0.02522534690797329,
-0.026102857664227486,
-0.011259329505264759,
-0.027536537498235703,
0.04436991363763809,
0.028302814811468124,
0.01063518412411213,
0.08661402761936188,
-0.05789099633693695,
-0.012056504376232624,
-0.011333485133945942,
-0.01222335547208786,
0.006908853072673082,
0.02798147313296795,
-0.046718183904886246,
-0.006188923493027687,
-0.030206147581338882,
0.02487928606569767,
-0.04721255600452423,
0.035273466259241104,
-0.004236152861267328,
0.02216023951768875,
-0.011549773626029491,
0.006476277485489845,
0.02075127698481083,
-0.00455131521448493,
0.02461974136531353,
-0.03171398490667343,
-0.07529290020465851,
-0.004180535674095154,
-0.04192277044057846,
-0.03403753414750099,
-0.009516666643321514,
0.007088063284754753,
-0.01993556320667267,
-0.027141040191054344,
0.00744648277759552,
-0.0012768709566444159,
0.055666323751211166,
0.009739134460687637,
0.02096138522028923,
0.0016252489294856787,
0.021443398669362068,
-0.017587294802069664,
0.007273452822118998,
-0.002127345884218812,
0.026671387255191803,
-0.06955818831920624,
0.011593030765652657,
-0.005725449416786432,
0.0007187710143625736,
-0.04135424271225929,
-0.053095586597919464,
-0.0003686549898702651,
0.030700521543622017,
0.02340852841734886,
-0.0473361499607563,
0.044048573821783066,
-0.006241450551897287,
0.02342088893055916,
-0.018885022029280663,
-0.046199094504117966,
0.026275888085365295,
0.020553529262542725,
0.028030909597873688,
-0.04234298691153526,
-0.02212316170334816,
0.002453322522342205,
0.035322900861501694,
-0.007409404963254929,
-0.06065948307514191,
0.0046594589948654175,
-0.0009763853158801794,
-0.017920996993780136,
0.05660562962293625,
-0.03406225144863129,
-0.021122056990861893,
0.04614965617656708,
-0.03819026052951813,
-0.038462165743112564,
-0.02526242472231388,
0.016672706231474876,
0.013335693627595901,
0.02272876724600792,
0.015103073790669441,
0.019700737670063972,
0.030206147581338882,
-0.045902468264102936,
0.003500774037092924,
-0.0011223796755075455,
0.09022294729948044,
-0.038116104900836945,
-0.057001128792762756,
-0.055073074996471405,
0.0408845916390419,
-0.004677997902035713,
0.05215628072619438,
-0.00920768454670906,
-0.042936235666275024,
-0.016561472788453102,
-0.016512034460902214,
-0.030354460701346397,
-0.06481221318244934,
0.0005125250318087637,
0.020640043541789055,
-0.024384913966059685,
-0.039698097854852676,
-0.010097554884850979,
-0.01863783597946167,
-0.03304878994822502,
0.015819914638996124,
0.010573388077318668,
0.021035542711615562,
0.030799394473433495,
-0.022926516830921173,
0.05279896408319473,
0.045037318021059036,
-0.01837829127907753,
-0.0022617534268647432,
-0.041601430624723434,
-0.02181417867541313,
0.047706928104162216,
-0.052996713668107986,
-0.05823705717921257,
-0.0395992211997509,
0.0074897403828799725,
-0.023272575810551643,
-0.0023405440151691437,
0.021789459511637688,
-0.023705152794718742,
-0.028302814811468124,
0.05255177617073059,
-0.056358445435762405,
-0.01721651665866375,
-0.056407880038022995,
-0.022493939846754074,
-0.0770232081413269,
-0.03524874523282051,
-0.04115649685263634,
0.0426148921251297,
0.008707132190465927,
-0.004492608364671469,
-0.02758597582578659,
-0.018056949600577354,
0.00498080113902688,
0.03215891867876053,
0.045556407421827316,
0.017587294802069664,
-0.023766949772834778,
0.011481797322630882,
-0.017401905730366707,
0.032134201377630234,
-0.06827281415462494,
-0.013422207906842232,
0.009306558407843113,
-0.00026244219043292105,
0.07539177685976028,
0.00830545462667942,
0.001025822595693171,
-0.011117197573184967,
0.04165086895227432,
0.0327027291059494,
-0.03967337682843208,
-0.01842772774398327,
0.01700640842318535,
-0.04644627869129181,
-0.026102857664227486,
0.00988126639276743,
-0.005258885677903891,
-0.01863783597946167,
-0.030552208423614502,
0.03060164675116539,
-0.01370647270232439,
0.021628789603710175,
0.02122093178331852,
-0.031194893643260002,
-0.010839113034307957,
0.006507175508886576,
-0.022184956818819046,
-0.05863255634903908,
0.012866039760410786,
0.02522534690797329,
0.000015775014617247507,
0.028871342539787292,
0.010276764631271362,
-0.04486428573727608,
-0.004690357483923435,
0.007736926898360252,
-0.007063344586640596,
0.009794751182198524,
0.0335678793489933,
-0.025163549929857254,
0.001364931114949286,
-0.01884794421494007,
-0.011883474886417389,
-0.004625470843166113,
0.005342310760170221,
-0.03663298860192299,
-0.04686649516224861,
0.010789675638079643,
0.04664402827620506,
-0.006723463535308838,
0.041774459183216095,
-0.006550433114171028,
-0.010591926984488964,
0.024248961359262466,
0.04795411601662636,
-0.014954762533307076,
-0.014967122115194798,
-0.005277424585074186,
-0.009263301268219948,
-0.059423550963401794,
0.001045906450599432,
-0.02555904909968376,
0.00556168844923377,
0.02099846489727497,
0.006507175508886576,
0.002754580695182085,
0.021665867418050766,
0.019910844042897224,
0.05625956878066063,
-0.02555904909968376,
0.005926288198679686,
-0.03287575766444206,
-0.0003381429414730519,
0.008855444379150867,
-0.03581727296113968,
-0.032134201377630234,
-0.04830017685890198,
0.013595238327980042,
-0.008237478323280811,
0.00590774929150939,
0.006244540214538574,
-0.03280160203576088,
0.036311645060777664,
0.026226451620459557,
0.034754373133182526,
-0.021937770769000053,
-0.05260121449828148,
-0.009529026225209236,
-0.005126022733747959,
0.044048573821783066,
0.02018274925649166,
0.008089167065918446,
0.004622381180524826,
0.022493939846754074,
-0.009646439924836159,
-0.025361299514770508,
-0.013026710599660873,
-0.038289137184619904,
0.00138269760645926,
0.006636948324739933,
0.02234562858939171,
-0.03354316204786301,
-0.0029677788261324167,
-0.025979265570640564,
-0.033642034977674484,
-0.033889222890138626,
-0.02642419934272766,
0.013088506646454334,
0.0018523512408137321,
-0.020034437999129295,
-0.03989584743976593,
0.04436991363763809,
-0.0568033792078495,
0.009491948410868645,
-0.014163766987621784,
-0.0331476628780365,
0.016734503209590912,
0.009800931438803673,
-0.003330833511427045,
-0.011277868412435055,
0.03354316204786301,
0.06258753687143326,
0.02798147313296795,
-0.0048788366839289665,
0.005811964627355337,
0.032307229936122894,
-0.0007500554784201086,
0.014954762533307076,
0.0019512256840243936,
-0.05289783701300621,
0.04024190455675125,
-0.04711368307471275,
-0.04140368103981018,
-0.003778858343139291,
-0.03692961111664772,
0.02366807498037815,
0.009603181853890419,
-0.0019172376487404108,
-0.017624372616410255,
-0.04407329112291336,
0.03883294388651848,
-0.03408697247505188,
0.019441191107034683,
-0.02832753397524357,
0.052106842398643494,
0.01600530371069908,
-0.005277424585074186,
-0.012964913621544838,
-0.05368883162736893,
-0.015004199929535389,
0.03920372575521469,
0.005058046896010637,
-0.015770476311445236,
0.03448246791958809,
-0.021455759182572365,
0.04105762019753456,
-0.0001547810243209824,
0.019119849428534508,
-0.01907041296362877,
0.009584642946720123,
-0.02246922254562378,
0.004838669206947088,
0.005036417860537767,
0.009634080342948437,
0.02220967598259449,
-0.015300823375582695,
-0.006056061014533043,
0.03586671128869057,
-0.041329525411129,
-0.031194893643260002,
0.01919400505721569,
0.013607597909867764,
0.005604946054518223,
-0.011129557155072689,
-0.005598766263574362,
0.034457750618457794,
0.052106842398643494,
0.06575151532888412,
-0.02065240405499935,
0.02723991498351097,
-0.006195103283971548,
-0.024891646578907967,
-0.009770032949745655,
-0.027660131454467773,
0.008367251604795456,
0.005768707022070885,
-0.0447654128074646,
0.03935203701257706,
0.012730087153613567,
0.01769852824509144,
-0.00394879886880517,
0.001227433793246746,
0.005367029458284378,
-0.03072523884475231,
-0.009152067825198174,
-0.04221939668059349,
0.012816602364182472,
0.031170174479484558,
0.0072610932402312756,
-0.01742662489414215,
-0.11627636849880219,
0.016969330608844757,
0.004504967946559191,
-0.011228431016206741,
-0.0009423972223885357,
0.016165975481271744,
-0.015992945060133934,
0.044567663222551346,
-0.015226667746901512,
0.07731983065605164,
0.03566896170377731,
0.03542177751660347,
0.003970427438616753,
-0.0314173623919487,
-0.023729871958494186,
-0.03072523884475231,
0.023124264553189278,
-0.015337901189923286,
0.043924979865550995,
0.0016715964302420616,
0.01687045581638813,
-0.008898701518774033,
-0.019947923719882965,
0.0055462392047047615,
0.03060164675116539,
0.02101082354784012,
-0.004965351894497871,
-0.031170174479484558,
-0.05190909281373024,
0.019305238500237465,
0.024248961359262466,
0.040143031626939774,
0.03952506557106972,
-0.004733615089207888,
0.011685725301504135,
-0.008589719422161579,
-0.0331476628780365,
-0.016425520181655884,
0.004118739161640406,
0.013632316142320633,
0.01043743547052145,
-0.06402121484279633,
0.0005457407096400857,
0.0598190501332283,
0.017401905730366707,
-0.028648875653743744,
-0.014003096148371696,
0.03416112810373306,
-0.04699008911848068,
0.01751313917338848,
-0.03685545548796654,
0.0017781953793019056,
-0.012495260685682297,
0.006556612905114889,
0.000706797931343317,
-0.0301319919526577,
0.027042165398597717,
0.015683962032198906,
-0.01116663496941328,
-0.03233195096254349,
-0.016821017488837242,
-0.03730039298534393,
-0.03418584540486336,
-0.017587294802069664,
-0.014979480765759945,
0.006043701432645321,
-0.03129376843571663,
-0.006420660298317671,
0.042417146265506744,
-0.05818762257695198,
0.026671387255191803,
0.03248026221990585,
0.04320814087986946,
-0.050252944231033325,
0.024372555315494537,
-0.043282296508550644,
0.003862283658236265,
0.05952242761850357,
0.05319445952773094,
-0.002009932417422533,
0.01095652673393488,
-0.034284718334674835,
0.006269258912652731,
0.006358863785862923,
0.0025243887212127447,
0.033419568091630936,
-0.008608258329331875,
0.03552065044641495,
0.025707360357046127,
0.0012436553370207548,
0.026028702035546303,
-0.023000672459602356,
-0.02122093178331852,
-0.009442511014640331,
0.008775108493864536,
0.008286915719509125,
0.006031342316418886,
0.05200796574354172,
-0.007959394715726376,
-0.019231082871556282,
-0.03895653784275055,
0.02630060724914074,
-0.009702056646347046,
-0.00841668900102377,
-0.004455530550330877,
-0.012359308078885078,
-0.009226223453879356,
-0.012365487404167652,
0.038882382214069366,
-0.02082543447613716,
0.01752549782395363,
0.005459724459797144,
-0.02793203666806221,
0.020158031955361366,
-0.0023590829223394394,
0.02573207952082157,
0.021715303882956505,
0.04731142893433571,
-0.0037541398778557777,
0.054727014154195786,
0.013990736566483974,
0.011716623790562153,
-0.032776884734630585,
-0.029687058180570602,
0.02130744606256485,
-0.023087186738848686,
-0.03648467734456062,
-0.01928052119910717,
-0.06782788038253784,
-0.01523902639746666,
0.0044400813058018684,
0.025114113464951515,
0.0008860079105943441,
0.0037108822725713253,
0.018094027414917946,
0.012489080429077148,
0.04162614792585373,
-0.04229355230927467,
-0.008472305722534657,
-0.0645650252699852,
-0.041255369782447815,
-0.033469006419181824,
0.05497420206665993,
-0.012767164967954159,
0.009318917989730835,
0.005221807397902012,
-0.00927566085010767,
-0.010023398324847221,
-0.012495260685682297,
0.033592600375413895,
-0.03065108321607113,
-0.037473421543836594,
0.017550216987729073,
0.0023992506321519613,
0.020689481869339943,
-0.010363279841840267,
-0.014275000430643559,
0.01355816051363945,
-0.0006558157620020211,
-0.034235283732414246,
0.0473361499607563,
0.013867143541574478,
0.03319710120558739,
-0.02207372337579727,
0.010659903287887573,
-0.01884794421494007,
0.005493712145835161,
-0.04464181885123253,
0.010035757906734943,
-0.023235497996211052,
-0.005997354164719582,
0.005759437568485737,
-0.026869134977459908,
-0.03317238390445709,
0.010418896563351154,
-0.021060260012745857,
-0.016722142696380615,
0.02892078086733818,
-0.004470979794859886,
-0.009522846899926662,
-0.020343421027064323,
0.014200844801962376,
-0.011209892109036446,
0.002674245275557041,
-0.0020083875861018896,
-0.0238905418664217,
0.05883030593395233,
0.000006040852895239368,
-0.022444503381848335,
0.02630060724914074,
-0.0018291776068508625,
0.018786147236824036,
-0.026251170784235,
-0.029390433803200722,
-0.0007720704888924956,
0.05005519837141037,
-0.02009623497724533,
0.03517458960413933,
-0.036904893815517426,
-0.008354892022907734,
-0.002626352943480015,
-0.011308766901493073,
0.021616429090499878,
0.005873761139810085,
0.020986104384064674,
0.02307482808828354,
-0.036138616502285004,
0.03379034623503685,
-0.023210780695080757,
0.0011841761879622936,
-0.036558832973241806,
0.014707576483488083,
0.006124036852270365,
-0.0026773351710289717,
-0.007774004712700844,
-0.04076099768280983,
-0.019268160685896873,
0.02565792389214039,
-0.03705320507287979,
-0.018452446907758713,
-0.022926516830921173,
0.015325541608035564,
0.05863255634903908,
0.02049173228442669,
-0.009967781603336334,
0.01850188337266445,
0.028821906074881554,
0.0018276326591148973,
-0.028723031282424927,
-0.017327750101685524,
-0.006507175508886576,
-0.020936667919158936,
-0.012346948496997356,
0.016685064882040024,
-0.016561472788453102,
0.00513220252469182,
-0.004084751475602388,
-0.043702512979507446,
-0.013941299170255661,
0.007532997988164425,
0.026671387255191803,
0.007168398704379797,
0.011265508830547333,
-0.013718831352889538,
-0.015572727657854557,
0.03047805279493332,
-0.015646884217858315,
-0.045951906591653824,
0.01300199143588543,
-0.010486872866749763,
-0.03514987230300903,
-0.01777268387377262,
-0.0028071077540516853,
0.0014815720496699214,
0.0027051435317844152,
-0.02224675379693508,
0.00724255433306098,
-0.023173702880740166,
-0.00940543320029974,
0.002056279918178916,
0.006179654039442539,
-0.0032195996027439833,
-0.017710888758301735,
-0.033469006419181824,
0.024928724393248558,
-0.010177889838814735,
0.00578724592924118,
-0.05645731836557388,
-0.023359091952443123,
0.005799605045467615,
0.052057404071092606,
0.06624589115381241,
-0.028698312118649483,
0.018106386065483093,
-0.023593919351696968,
-0.029588183388113976,
0.004844848532229662,
0.007001548074185848,
0.028994936496019363,
-0.019255802035331726,
0.02474333345890045,
-0.00792231597006321,
0.06520770490169525,
0.013694113120436668,
0.008904881775379181,
-0.03065108321607113,
-0.004158907104283571,
-0.0011208347277715802,
0.013249178417026997,
-0.01782212220132351,
-0.015473853796720505,
0.003849924309179187,
-0.013830065727233887,
0.000556168844923377,
-0.031911734491586685,
-0.07820969820022583,
0.035446494817733765,
-0.008280736394226551,
0.012606494128704071,
-0.024248961359262466,
0.03166454657912254,
-0.006371223367750645,
0.003423528280109167,
-0.03416112810373306,
-0.033122945576906204,
-0.005376298911869526,
0.02423660270869732,
0.012890757992863655,
0.005638934206217527,
-0.002580005442723632,
-0.022963594645261765,
0.02617701329290867,
0.020862512290477753,
0.0191569272428751,
0.03739926591515541,
-0.02607814036309719,
0.005901569500565529,
-0.024298399686813354,
0.0034111689310520887,
-0.005858311895281076,
0.0010536309564486146,
0.01600530371069908,
0.013484004884958267,
-0.009838009253144264,
-0.033938661217689514,
-0.011617748998105526,
-0.01177224051207304,
-0.009998680092394352,
-0.028599439188838005,
0.06263697147369385,
-0.00706952391192317,
0.00820040050894022,
-0.0021381601691246033,
0.014213204383850098,
-0.03416112810373306,
0.010666082613170147,
0.028179222717881203,
0.03433415666222572,
-0.026102857664227486,
0.060708921402692795,
-0.014794091694056988,
-0.012414924800395966,
-0.004631650634109974,
-0.03680601716041565,
-0.019725454971194267,
-0.015807554125785828,
0.005626575089991093,
0.020293982699513435,
-0.008150963112711906,
0.005604946054518223,
-0.0013525717658922076,
-0.007563896477222443,
0.02600398287177086,
-0.06229091063141823,
-0.044518228620290756,
0.0039858766831457615,
0.0029600542038679123,
0.03727567195892334,
0.005435005761682987,
0.020120952278375626,
0.0038931819144636393,
-0.02914324775338173,
0.0055585987865924835,
0.009491948410868645,
0.0023652624804526567,
-0.022827642038464546,
0.0039086309261620045,
-0.033889222890138626,
0.00981329008936882,
-0.008225119672715664,
-0.028426408767700195,
-0.030848832800984383,
-0.029242122545838356,
0.027734287083148956,
-0.01431207824498415,
0.012557056732475758,
0.008157143369317055,
0.004585303366184235,
0.026696104556322098,
0.016821017488837242,
-0.020714199170470238,
0.00573471887037158,
-0.0071127815172076225,
-0.014559264294803143,
-0.0030681982170790434,
-0.023396169766783714,
-0.00296932365745306,
0.021455759182572365,
-0.017834480851888657,
0.0018724350957199931,
-0.023186061531305313,
0.006133306305855513,
0.00917060673236847,
0.008015011437237263,
-0.03060164675116539,
0.020417576655745506,
-0.008021190762519836,
-0.004983890801668167,
-0.019169285893440247,
0.012655931524932384,
-0.023210780695080757,
-0.0009215408936142921,
-0.034284718334674835,
0.03722623363137245,
-0.02449614740908146,
0.012359308078885078,
-0.017920996993780136,
0.03163982927799225,
0.03433415666222572,
-0.09145887941122055,
-0.003361731767654419,
-0.007483561057597399,
0.023791667073965073,
-0.010270584374666214,
0.00741558475419879,
-0.03317238390445709,
-0.017661450430750847,
-0.0008188041392713785,
-0.02973649464547634,
-0.003096006577834487,
-0.013595238327980042,
-0.011623929254710674,
-0.012470541521906853,
0.005064226221293211,
-0.03238138556480408,
-0.014781732112169266,
-0.021319806575775146,
-0.011141915805637836,
0.02513883262872696,
0.017871558666229248,
0.007088063284754753,
-0.0286241564899683,
0.04634740576148033,
0.007440303452312946,
0.03564424440264702,
-0.018835585564374924,
0.000354557647369802,
-0.0421946756541729,
0.0013355776900425553,
0.03327125683426857,
0.011420000344514847,
-0.01777268387377262,
0.038709353655576706,
-0.024607382714748383,
-0.05027766525745392,
0.02332201413810253,
-0.009306558407843113,
0.005632754415273666,
-0.003525492502376437,
0.01209358312189579,
-0.00027422214043326676,
0.013966018334031105,
0.006204372737556696,
-0.0003526264918036759,
-0.028673594817519188,
-0.02948930859565735,
-0.017500780522823334,
0.007409404963254929,
-0.028253378346562386,
0.028896061703562737,
-0.02397705800831318,
-0.017364827916026115,
0.0022586635313928127,
-0.022197317332029343,
0.0016638718079775572,
0.0030496593099087477,
0.037770044058561325,
0.02543545514345169,
0.013434567488729954,
-0.013076147995889187,
0.06530658155679703,
0.037943076342344284,
-0.005005519837141037,
0.010214967653155327,
-0.004690357483923435,
-0.028994936496019363,
0.027338789775967598,
-0.04859679937362671,
0.01759965531527996,
-0.020949026569724083,
0.011172814294695854,
-0.036262210458517075,
0.034803811460733414,
-0.004634740296751261,
0.030008399859070778,
-0.01252615824341774,
0.0018446267349645495,
-0.012371666729450226,
0.01756257563829422,
-0.010851472616195679,
-0.012519978918135166,
-0.002688149455934763,
0.036212772130966187,
-0.024817490950226784,
-0.006365043576806784,
0.010882370173931122,
0.013508723117411137,
0.0077925436198711395,
-0.0036336365155875683,
-0.010468333959579468,
-0.00034915044670924544,
-0.009664978832006454,
0.010270584374666214,
-0.008775108493864536,
-0.01738954707980156,
-0.040662121027708054,
-0.0023992506321519613,
-0.018922099843621254,
-0.011871115304529667,
0.03129376843571663,
-0.03774532675743103,
0.0008249838137999177,
-0.025979265570640564,
-0.018699632957577705,
-0.01949062943458557,
0.04844848811626434,
0.0012104397173970938,
0.00631560618057847,
-0.003995146136730909,
0.03319710120558739,
0.006402121391147375,
0.011827857233583927,
0.0005546239553950727,
0.018922099843621254,
0.03438359498977661,
0.035322900861501694,
-0.03322181850671768,
0.013582879677414894,
-0.001586626167409122,
0.07549065351486206,
0.00238843634724617,
0.018526602536439896,
0.00477687269449234,
-0.01446039043366909,
0.0003937598376069218,
0.01941647194325924,
-0.011005963198840618,
0.00590774929150939,
0.001323218340985477,
0.026325326412916183,
0.013570520095527172,
0.004925184417515993,
-0.005441185086965561,
-0.010622825473546982,
0.049610260874032974,
0.017958074808120728,
0.007465022150427103,
-0.01099360454827547,
0.015980584546923637,
-0.003513133153319359,
-0.017142359167337418,
0.0034204383846372366,
-0.020689481869339943,
0.03937675431370735,
-0.012180098332464695,
-0.04661931097507477,
0.013966018334031105,
0.016499675810337067,
0.013286256231367588,
-0.03379034623503685,
0.01652439497411251,
0.04587775096297264,
0.03371619060635567,
-0.0056358445435762405,
0.030552208423614502,
0.044617101550102234,
-0.019663657993078232,
-0.0069768293760716915,
0.009423972107470036,
-0.03804194927215576,
0.06609757989645004,
-0.04980801045894623,
-0.040612686425447464,
0.025188269093632698,
-0.015510931611061096,
0.016203053295612335,
0.006754361558705568,
0.04923948273062706,
0.016067100688815117,
0.008787468075752258,
-0.0671357586979866,
0.024854568764567375,
0.01691989228129387,
-0.01146943774074316,
0.03245554119348526,
0.028525281697511673,
0.021233290433883667,
0.014769372530281544,
0.03685545548796654,
-0.031145455315709114,
-0.014855887740850449,
0.0003344737633597106,
0.03715207800269127,
0.025064677000045776,
0.008589719422161579,
0.006748182233422995,
-0.017809763550758362,
0.024805130437016487,
0.0032288692891597748,
-0.008101526647806168,
-0.0318375788629055,
-0.005691461265087128,
0.06594926863908768,
0.031788140535354614,
-0.029340997338294983,
-0.03791835531592369,
0.019169285893440247,
-0.02130744606256485,
-0.059670738875865936,
-0.05512251332402229,
0.02101082354784012,
0.01945354975759983,
-0.02517591044306755,
-0.026251170784235,
0.026696104556322098,
0.0013641585828736424,
-0.039747532457113266,
-0.01164246816188097,
0.039055414497852325,
0.005472083576023579,
0.02978593111038208,
-0.019737815484404564,
-0.01370647270232439,
0.02212316170334816,
0.011611569672822952,
0.022098442539572716,
0.0036768941208720207,
-0.023593919351696968,
-0.009634080342948437,
-0.03564424440264702,
-0.03819026052951813,
-0.001096888561733067,
-0.014670498669147491,
0.0008357982151210308,
0.003235048847272992,
0.009294199757277966,
0.015399697236716747,
-0.00669256504625082,
0.009547565132379532,
-0.025361299514770508,
0.010004859417676926,
0.025101754814386368,
0.012866039760410786,
0.005774886813014746,
-0.003355551976710558,
-0.013694113120436668,
-0.01962658017873764,
0.0007824986823834479,
-0.006958290468901396,
0.04493844509124756,
0.008342532441020012,
-0.0009725230629555881,
-0.045086756348609924,
-0.024125369265675545,
-0.022456862032413483,
0.03149151802062988,
-0.024347836151719093,
-0.013113225810229778,
-0.008015011437237263,
-0.0053392210975289345,
-0.011259329505264759,
0.035570088773965836,
0.02457030490040779,
0.019231082871556282,
0.004010595381259918,
0.0040631224401295185,
0.0033431928604841232,
0.054430391639471054,
0.02122093178331852,
-0.008972857147455215,
-0.0035687501076608896,
-0.006704924628138542,
-0.01850188337266445,
0.021455759182572365,
-0.00892960000783205,
-0.016277208924293518,
-0.009090270847082138,
-0.002770029939711094,
-0.0026000894140452147,
0.020850151777267456,
0.03757229447364807,
0.0025676460936665535,
0.000320183316944167,
-0.0002178327995352447,
-0.017797403037548065,
0.003877732902765274,
-0.015350260771811008,
-0.011691905558109283,
-0.01799515262246132,
0.005150741431862116,
-0.018094027414917946,
-0.021072620525956154,
-0.018316494300961494,
0.010629004798829556,
0.02543545514345169,
0.012989632785320282,
0.0035224028397351503,
0.02333437278866768,
-0.019638940691947937,
-0.018687274307012558,
-0.01708056405186653,
-0.01332333404570818,
-0.019119849428534508,
-0.0013556615449488163,
-0.008497023954987526,
-0.009522846899926662,
0.016450239345431328,
0.0037356007378548384,
-0.03181285783648491,
-0.0008188041392713785,
0.007613333873450756,
-0.002444053068757057,
-0.032603852450847626,
0.017673810943961143,
-0.002827191725373268,
-0.011111017316579819,
-0.03413640707731247,
0.03292519599199295,
-0.023989416658878326,
-0.0464957170188427,
0.0039086309261620045,
0.01846480555832386,
-0.005722359754145145,
0.013471645303070545,
0.006630768533796072,
-0.01480645127594471,
0.00036730317515321076,
-0.005379388574510813,
0.001677775988355279,
-0.04184861481189728,
0.0015186499804258347,
-0.007390866056084633,
-0.011766061186790466,
-0.020219827070832253,
-0.027338789775967598,
-0.007761645130813122,
-0.03206004574894905,
-0.014237922616302967,
-0.016598550602793694,
-0.0025367478374391794,
-0.020034437999129295,
0.005774886813014746,
0.00787287950515747,
0.001323218340985477,
0.010190249420702457,
-0.00037039301241748035,
-0.011623929254710674,
-0.006371223367750645,
0.004189805593341589,
0.006902673281729221,
0.006507175508886576,
0.02758597582578659,
-0.00841668900102377,
0.018353572115302086,
-0.00558331748470664,
0.005342310760170221,
-0.025682641193270683,
-0.016240131109952927,
-0.010468333959579468,
0.052106842398643494,
-0.05349108576774597,
-0.03705320507287979,
0.03542177751660347,
-0.010023398324847221,
-0.0026696105487644672,
-0.00951048731803894,
0.021801818162202835,
-0.002450232859700918,
-0.005431915633380413,
-0.005138382315635681,
0.03769588842988014,
0.03801723197102547,
-0.02548489347100258,
-0.010252045467495918,
0.03576783835887909,
-0.021702945232391357,
-0.005638934206217527,
0.0037819482386112213,
0.007947035133838654,
0.027338789775967598,
0.006711103953421116,
-0.017673810943961143,
0.00854646135121584,
-0.012550877407193184,
0.02440963312983513,
0.019947923719882965,
0.010128452442586422,
-0.00186162069439888,
0.03008255548775196,
0.012890757992863655,
-0.0045945728197693825,
-0.03856104239821434,
-0.011982348747551441,
-0.007471201475709677,
-0.01181549858301878,
-0.02104790136218071,
-0.009912164881825447,
-0.004013685043901205,
0.006105497945100069,
-0.006195103283971548,
-0.00820040050894022,
0.012495260685682297,
-0.017673810943961143,
-0.043578919023275375,
-0.02827809564769268,
-0.015399697236716747,
-0.010863831266760826,
-0.008336353115737438,
0.010227327235043049,
-0.03136792406439781,
-0.0004457075265236199,
0.0256084855645895,
-0.003791217692196369,
0.007013907190412283,
0.014472749084234238,
-0.007749286014586687,
0.030206147581338882,
0.01884794421494007,
0.015498572029173374,
-0.004010595381259918,
-0.006062240339815617,
-0.04916532710194588,
0.015486212447285652,
-0.03292519599199295,
-0.00002594971920188982,
-0.00796557404100895,
-0.029390433803200722,
-0.020936667919158936,
-0.029637619853019714,
-0.004844848532229662,
-0.004041493870317936,
-0.005450454540550709,
-0.02427368052303791,
-0.01643787883222103,
0.0029677788261324167,
0.007440303452312946,
0.0003850696957670152,
-0.04498787969350815,
0.006717283744364977,
0.01928052119910717,
0.008898701518774033,
0.009269480593502522,
0.005601856391876936,
-0.017018767073750496,
-0.004106380045413971,
-0.0039148107171058655,
0.014954762533307076,
-0.009121169336140156,
-0.0016113447491079569,
-0.00006440358265535906,
-0.015115433372557163,
0.05789099633693695,
0.0072672730311751366,
0.013063788414001465,
-0.044790130108594894,
0.00611167773604393,
0.00003608821498346515,
0.010196428745985031,
0.027511820197105408,
0.029390433803200722,
0.0034111689310520887,
-0.03317238390445709,
-0.021875975653529167,
-0.023470325395464897,
0.009077911265194416,
-0.016536753624677658,
-0.016882814466953278,
-0.01562216505408287,
0.017315389588475227,
-0.03673186153173447,
0.006124036852270365,
0.01280424278229475,
0.01898389682173729,
0.0009400798589922488,
-0.000406698469305411,
0.0041403681971132755,
-0.013236818835139275,
-0.014448030851781368,
-0.014349156059324741,
0.008188041858375072,
0.008138604462146759,
0.0138795031234622,
-0.011067760176956654,
0.02482984960079193,
0.0028395510744303465,
0.025756796821951866,
0.020306343212723732,
0.012853680178523064,
-0.011871115304529667,
-0.0486462339758873,
0.008169502951204777,
0.010208788327872753,
-0.015337901189923286,
0.038239698857069016,
0.013792987912893295,
0.008169502951204777,
0.004090930800884962,
0.04019246995449066,
-0.010103734210133553,
0.01841536909341812,
0.0045945728197693825,
-0.003831385402008891,
0.0006944385822862387,
-0.013916580937802792,
-0.0025073946453630924,
0.030033119022846222,
0.002065549371764064,
-0.011148096062242985,
-0.008738030679523945,
-0.003785038134083152,
-0.026498356834053993,
-0.00824365857988596,
-0.011654827743768692,
-0.001252152374945581,
0.011902013793587685,
-0.029365714639425278,
-0.04760805517435074,
0.018328852951526642,
0.005574048031121492,
-0.005354670342057943,
-0.011049221269786358,
-0.01941647194325924,
0.02130744606256485,
0.0443451963365078,
-0.0357184000313282,
-0.010270584374666214,
0.017377186566591263,
0.011895833536982536,
0.0032103301491588354,
0.025274785235524178,
0.026448918506503105,
0.033642034977674484,
0.008836905471980572,
-0.0005832048482261598,
-0.018131105229258537,
0.005784156266599894,
0.028723031282424927,
-0.009331277571618557,
0.00666166702285409,
0.02810506522655487,
-0.02018274925649166,
0.014905325137078762,
-0.017228875309228897,
-0.057396624237298965,
0.05005519837141037,
-0.017636733129620552,
-0.00550916139036417,
-0.035570088773965836,
-0.027264632284641266,
-0.011963809840381145,
0.026572512462735176,
0.025509610772132874,
-0.01640080101788044,
-0.0015425961464643478,
0.041329525411129,
0.023964697495102882,
-0.02191305346786976,
-0.002182962838560343,
0.02943987213075161,
0.047410305589437485,
0.014707576483488083,
-0.015127792954444885,
-0.008657694794237614,
-0.029761213809251785,
-0.03302406892180443,
0.004915914498269558,
-0.00596027635037899,
-0.033419568091630936,
-0.00666166702285409,
0.008614437654614449,
0.015350260771811008,
0.01579519547522068,
0.023470325395464897,
0.007273452822118998,
0.010313842445611954,
-0.0062970672734081745,
-0.007409404963254929,
-0.021332165226340294,
0.019391754642128944,
-0.03025558590888977,
-0.019231082871556282,
-0.006884134374558926,
-0.010826753452420235,
-0.015201948583126068,
0.03566896170377731,
0.014237922616302967,
0.01751313917338848,
-0.002427058992907405,
0.014163766987621784,
-0.02457030490040779,
0.011914372444152832,
-0.027363507077097893,
0.0014699852326884866,
0.013335693627595901,
-0.017673810943961143,
-0.04382610693573952,
-0.015461494214832783,
-0.004486428573727608,
0.016549114137887955,
-0.05010463297367096,
0.00422688340768218,
0.013051428832113743,
-0.00658751092851162,
-0.0012737811775878072,
0.038931820541620255,
0.015090715140104294,
-0.008144783787429333,
-0.02444671094417572,
-0.009566104039549828,
-0.020454654470086098,
0.03374091163277626,
-0.013928939588367939,
-0.015782836824655533,
-0.0014723025960847735,
-0.01855132170021534,
-0.019700737670063972,
-0.007224015425890684,
-0.026720823720097542,
-0.008497023954987526,
-0.03379034623503685,
-0.01726595312356949,
-0.002851910190656781,
-0.012649751268327236,
-0.001318583614192903,
0.028376970440149307,
-0.037473421543836594,
-0.019737815484404564,
-0.009634080342948437,
0.03107129968702793,
0.023556841537356377,
0.059423550963401794,
-0.02005915716290474,
0.009096450172364712,
0.02689385414123535,
-0.001775105600245297,
-0.03112073801457882,
0.030033119022846222,
0.03801723197102547,
-0.017920996993780136,
0.007335249334573746,
0.0038035770412534475,
0.002763850148767233,
-0.036558832973241806,
0.012754805386066437,
-0.02978593111038208,
-0.016042381525039673,
0.0027623053174465895,
-0.0391542874276638,
0.0271163210272789,
0.0021659687627106905,
0.027857879176735878,
0.018056949600577354,
0.019292879849672318,
-0.030675802379846573,
0.022963594645261765,
-0.005774886813014746,
-0.017241233959794044,
0.012087402865290642,
-0.014497468248009682,
-0.013607597909867764,
0.021789459511637688,
0.004764513112604618,
0.0038344752974808216,
0.039055414497852325,
0.01198852900415659,
-0.02130744606256485,
0.034111689776182175,
-0.012112122029066086,
-0.03082411363720894,
0.024038853123784065,
0.0008921875269152224,
0.011481797322630882,
0.030057836323976517,
0.01506599597632885,
-0.016808658838272095,
0.008021190762519836,
0.027783723548054695,
-0.0344330333173275,
-0.011525054462254047,
-0.04197220876812935,
-0.002473406493663788,
-0.04308454692363739,
0.012044145725667477,
0.12003359943628311,
0.0022509389091283083,
0.015634523704648018,
0.030156711116433144,
0.004480249248445034,
-0.009121169336140156,
0.022753486409783363,
-0.015548009425401688,
0.018699632957577705,
-0.008317814208567142,
0.016240131109952927,
0.0012019426794722676,
0.03285104036331177,
0.006151845678687096,
0.022357987239956856,
-0.014250282198190689,
0.016512034460902214,
0.044271040707826614,
-0.02479277178645134,
0.0037417805287986994,
0.00933745689690113,
0.0038900922518223524,
-0.01674686186015606,
0.03332069516181946,
-0.024693896993994713,
0.006321785971522331,
-0.006915032863616943,
-0.01198852900415659,
-0.01666034758090973,
-0.018563680350780487,
0.015436775982379913,
0.014349156059324741,
0.017636733129620552,
-0.006853236351162195,
-0.007977933622896671,
-0.019774893298745155,
-0.02548489347100258,
-0.045605845749378204,
0.01648731715977192,
-0.0005635072011500597,
0.00813242420554161,
0.0014815720496699214,
0.010338560678064823,
0.008033550344407558,
0.02078835666179657,
-0.0024471429642289877,
-0.029983680695295334,
0.019354676827788353,
0.008941959589719772,
0.007131320424377918,
0.0001224343868670985,
-0.0018399920081719756,
0.005237256642431021,
-0.006933571770787239,
-0.042590174823999405,
-0.02793203666806221,
0.02065240405499935,
0.0005503754364326596,
-0.00930037908256054,
-0.03925316035747528,
-0.023532122373580933,
0.0178592000156641,
0.0014622606104239821,
-0.006995368283241987,
0.016215411946177483
] | 2025-01-03 | 72 | 39747430 | [
"cognate T cell antigen experience",
"CAR T cell function",
"post-CAR relapse",
"rational manipulations",
"other tumors",
"subsequent CD8",
"efficacy",
"CAR",
"B-lineage malignancies",
"the impact",
"These challenges",
"we"
] | [] | 0 | 10.1038/s41590-024-02034-1 | [
"DeGolier",
"Danis",
"D'Antonio",
"Cimons",
"Yarnell",
"Kedl",
"Kohler",
"Scott-Browne",
"Fry"
] | [
"Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.\nDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.",
"Biostatistics and Bioinformatics Shared Resource, University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.",
"Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.",
"Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.\nDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.",
"Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.\nCenter for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA.",
"Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.",
"Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.\nDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.\nCenter for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA.",
"Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.\nDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, CO, USA.",
"Department of Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. [email protected].\nDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. [email protected].\nCenter for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora, CO, USA. [email protected]."
] | [
"39747430",
"36813894",
"26369987",
"31554741",
"36255386",
"37046597",
"33644866",
"26205583",
"34971569",
"29155426",
"32193224",
"21903423",
"24493801",
"21653320",
"30209120",
"27460500",
"29167392",
"37516968",
"34433030",
"30194241",
"17555991",
"16025119",
"28825706",
"27939672",
"17950003",
"16492737",
"16199517",
"35263570",
"36240777",
"34282330",
"31802004",
"36350991",
"30814732",
"36350986",
"35675405",
"33820778",
"33020644",
"36849828",
"31924795",
"38600376",
"38600391",
"25267651",
"17237405",
"22178730",
"15007094",
"38966037",
"17507664",
"21984804",
"22031866",
"38640253",
"22537242",
"36070691",
"35953487",
"34421907",
"34285077",
"20631379",
"19561539",
"25075903",
"28846090",
"26083756",
"30254741",
"27312411",
"23104886",
"25516281",
"31372651",
"30944313",
"24336805",
"12808457",
"20110278",
"25605792",
"20513432",
"24799436"
] | [] | 8.060258 | 4.934047 |
39747173 | 86 | Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung. | Suppression of chimeric antigen receptor-modified T (CAR-T) cells by the immunosuppressive tumor microenvironment remains a major barrier to their efficacy against solid tumors. To address this, we develop an anti-PD-L1-expressing nanovesicle loaded with the STING agonist cGAMP (aPD-L1 NVs@cGAMP) to remodel the tumor microenvironment and thereby enhance CAR-T cell activity. Following pulmonary delivery, the nanovesicles rapidly accumulate in the lung and selectively deliver STING agonists to PD-L1-overexpressing cells via the PD-1/PD-L1 interaction. This targeted delivery effectively avoids the systemic inflammation and poor cellular uptake that plague free STING agonists. Internalized STING agonists trigger STING signaling and induce interferon responses, which diminish immunosuppressive cell populations such as myeloid-derived suppressor cells in the tumor microenvironment and promote CAR-T cell infiltration. Importantly, the anti-PD-L1 single chain variable fragment on the nanovesicle surface blocks PD-L1 upregulation induced by STING agonists and prevents CAR-T cell exhaustion. In both orthotopic lung cancer and lung metastasis model, combined therapy with CAR-T cells and aPD-L1 NVs@cGAMP potently inhibits tumor growth and prevents recurrence. Therefore, aPD-L1 NVs@cGAMP is expected to serve as an effective CAR-T cell enhancer to improve the efficacy of CAR-T cells against solid tumors. | [
0.0389421321451664,
-0.018263742327690125,
0.015967458486557007,
0.03534383326768875,
-0.0594666488468647,
-0.03771113604307175,
-0.025850947946310043,
0.009694105945527554,
0.007326802704483271,
-0.03697727248072624,
-0.007309047970920801,
0.0248093344271183,
-0.03354468196630478,
-0.028005193918943405,
0.017553551122546196,
-0.009995936416089535,
-0.005663772113621235,
-0.01824006997048855,
-0.001027557416819036,
0.028076212853193283,
0.056105080991983414,
0.0006077310536056757,
-0.01258221548050642,
0.0160976592451334,
-0.0346573144197464,
-0.02885742299258709,
0.03013576753437519,
0.036077696830034256,
0.005808769725263119,
0.014937682077288628,
0.01363566517829895,
-0.009001669473946095,
-0.038373980671167374,
-0.029165172949433327,
-0.0011888300068676472,
0.04540487006306648,
0.037024617195129395,
0.01880822144448757,
-0.022998347878456116,
-0.011475500650703907,
0.013659338466823101,
0.001312373555265367,
0.017281312495470047,
0.08081972599029541,
-0.011593866162002087,
0.027957847341895103,
-0.02301018498837948,
-0.023223241791129112,
0.013375261798501015,
0.006575183942914009,
-0.021885715425014496,
-0.006208252161741257,
-0.039533957839012146,
0.029117826372385025,
-0.015032373368740082,
0.011564275249838829,
0.016867034137248993,
0.008036993443965912,
-0.058851152658462524,
0.034846700727939606,
0.01307934895157814,
-0.03236103057861328,
0.031059015542268753,
0.009463293477892876,
-0.03366304934024811,
0.011576111428439617,
-0.05032886192202568,
0.001387831405736506,
0.029804343357682228,
0.013860559090971947,
0.02179102413356304,
0.017482532188296318,
-0.008800448849797249,
-0.007628633640706539,
0.012345485389232635,
0.013327915221452713,
0.03527281433343887,
0.03939191997051239,
0.004941744729876518,
-0.011297953315079212,
0.03709563612937927,
-0.01302016619592905,
0.027176637202501297,
-0.041522495448589325,
0.004027374088764191,
-0.03910784423351288,
-0.021128179505467415,
-0.05184393376111984,
-0.044102855026721954,
0.02047717012465,
-0.014144634827971458,
0.030632900074124336,
-0.07035624235868454,
0.03659850358963013,
-0.01311485841870308,
0.038539692759513855,
0.015683382749557495,
-0.06263883411884308,
0.061597224324941635,
0.0439608171582222,
0.04081230238080025,
-0.02639542892575264,
0.004270022734999657,
-0.02321140468120575,
0.023554664105176926,
0.050707630813121796,
-0.03101166896522045,
0.028691712766885757,
0.039060499519109726,
-0.010055119171738625,
0.10198341310024261,
0.004725728649646044,
-0.026774195954203606,
0.07764753699302673,
-0.027650099247694016,
-0.03342631831765175,
-0.02944924868643284,
0.01844128966331482,
0.01206732727587223,
0.03501240909099579,
-0.043747760355472565,
0.02511708438396454,
-0.0011074539506807923,
-0.022690599784255028,
-0.017458859831094742,
-0.04180657118558884,
0.069504015147686,
-0.037663791328668594,
-0.006444982253015041,
-0.02814723178744316,
0.0103983785957098,
-0.009883489459753036,
0.06505348533391953,
-0.012534868903458118,
-0.07864180207252502,
-0.008735347539186478,
-0.05724138393998146,
0.001882005832158029,
-0.016109496355056763,
0.006024785805493593,
0.029236191883683205,
-0.015375632792711258,
0.004651750437915325,
-0.010504906997084618,
-0.029472921043634415,
-0.06779955327510834,
0.0026262267492711544,
0.035201795399188995,
-0.021317563951015472,
0.069504015147686,
-0.043274298310279846,
0.06974074244499207,
0.061549875885248184,
-0.011422236450016499,
0.0119252884760499,
0.004264104645699263,
0.0008906977600418031,
0.04606771469116211,
-0.02528279647231102,
-0.060318879783153534,
-0.003204736392945051,
-0.002679490949958563,
-0.0029901994857937098,
-0.02134123630821705,
0.028312943875789642,
-0.03311856836080551,
-0.005181434564292431,
0.003246164182201028,
-0.06415390968322754,
-0.02078492008149624,
-0.023436298593878746,
-0.03056188113987446,
-0.033165913075208664,
0.004039210733026266,
-0.04535752534866333,
-0.004323286935687065,
-0.02540116012096405,
-0.01670132204890251,
0.009327173233032227,
0.013363425619900227,
-0.023388953879475594,
0.049192555248737335,
0.05321697145700455,
-0.034752007573843,
-0.02821825072169304,
0.029520267620682716,
-0.010765310376882553,
0.0744280070066452,
-0.04793788492679596,
-0.0037492159754037857,
0.0011518409010022879,
-0.00914370734244585,
0.03349733725190163,
0.04829297959804535,
-0.012771599926054478,
-0.01936453767120838,
0.015067883767187595,
0.017660079523921013,
0.014854826033115387,
-0.04419754445552826,
0.028668038547039032,
0.014712788164615631,
-0.03453895077109337,
0.009155544452369213,
-0.017778445035219193,
-0.05411654710769653,
-0.04552323743700981,
0.05643650144338608,
0.02042982541024685,
0.0352964885532856,
0.04201962798833847,
0.0303724966943264,
0.027010926976799965,
-0.011463664472103119,
0.006882933434098959,
0.018074357882142067,
-0.00816719513386488,
0.038066230714321136,
0.040409862995147705,
0.015931949019432068,
0.00705456268042326,
0.0004065103130415082,
-0.021234707906842232,
0.003947477787733078,
0.007616797462105751,
-0.015801746398210526,
0.016511937603354454,
-0.032053280621767044,
0.011877942830324173,
-0.02364935725927353,
-0.021802859380841255,
0.00730312941595912,
-0.00485001178458333,
-0.026726851239800453,
-0.004554098937660456,
0.015032373368740082,
0.03773481026291847,
-0.0010882195783779025,
0.03477568179368973,
0.003485853550955653,
-0.01091326680034399,
0.02499871887266636,
0.027768462896347046,
-0.031224725767970085,
-0.011735904030501842,
0.010504906997084618,
-0.011321626603603363,
-0.06306494772434235,
0.0013049757108092308,
0.013032002374529839,
0.016878869384527206,
-0.017541714012622833,
-0.016677649691700935,
-0.050139475613832474,
0.004787870217114687,
-0.011617539450526237,
0.013008330017328262,
-0.008214541710913181,
0.012452013790607452,
-0.024738315492868423,
0.06377514451742172,
0.016949888318777084,
-0.037261348217725754,
-0.04455264285206795,
-0.03659850358963013,
-0.004995009396225214,
-0.004574812948703766,
0.006444982253015041,
0.039652325212955475,
0.015636036172509193,
0.01975514367222786,
0.008830039761960506,
0.02715296484529972,
0.008699838072061539,
-0.027176637202501297,
0.01884373091161251,
0.01466544158756733,
0.023945270106196404,
-0.005077864974737167,
0.0303724966943264,
-0.04161718487739563,
-0.01796782948076725,
-0.013174041174352169,
0.010694291442632675,
-0.04976070672273636,
-0.005101537797600031,
-0.0011762536596506834,
-0.01367117464542389,
-0.04048088192939758,
-0.06197599321603775,
-0.004003701265901327,
-0.011570192873477936,
-0.028360288590192795,
0.01847679913043976,
0.0006306642899289727,
0.010593680664896965,
-0.007918628863990307,
-0.008895141072571278,
0.014061779715120792,
0.0340181440114975,
-0.011019795201718807,
0.005725914146751165,
-0.01805068552494049,
-0.03266878053545952,
-0.006711303722113371,
-0.012747926637530327,
-0.0005522473948076367,
-0.03808990493416786,
-0.010629190132021904,
0.03247939795255661,
0.06169191375374794,
-0.007415576372295618,
0.01462993212044239,
-0.002257815096527338,
0.03600667789578438,
0.012712417170405388,
0.04296654835343361,
-0.037308692932128906,
0.0014551515923812985,
-0.026845214888453484,
-0.019293518736958504,
0.04519181326031685,
-0.015612362883985043,
-0.02897578850388527,
0.014286673627793789,
-0.010558171197772026,
0.08200337737798691,
-0.029165172949433327,
0.00803107488900423,
-0.007202519103884697,
-0.0048914398066699505,
-0.01138672698289156,
0.03437323868274689,
-0.01928168348968029,
0.0017621611477807164,
-0.012759762816131115,
-0.030916975811123848,
-0.0682256743311882,
0.01876087673008442,
0.012889964506030083,
-0.04478937014937401,
0.01948290318250656,
-0.03522546961903572,
0.039036825299263,
0.010362869128584862,
0.011161833070218563,
0.009037178941071033,
-0.002111338311806321,
0.02738969586789608,
0.051654551178216934,
0.014878499321639538,
0.03131941705942154,
0.01940004713833332,
0.03278714418411255,
0.009812470525503159,
0.004758278839290142,
-0.002643981482833624,
-0.0408596508204937,
-0.0038143168203532696,
-0.007906791754066944,
-0.010528580285608768,
0.010078792460262775,
-0.0439608171582222,
0.02039431408047676,
0.023388953879475594,
0.014322183094918728,
-0.03932090103626251,
0.03747440502047539,
-0.012262629345059395,
-0.03624340891838074,
0.029472921043634415,
0.034278545528650284,
0.010031445883214474,
0.06140783801674843,
-0.00932125560939312,
0.051181089133024216,
0.03314224258065224,
0.011197342537343502,
0.032100629061460495,
-0.019411884248256683,
0.03764011710882187,
-0.003485853550955653,
-0.0037196248304098845,
0.02015758492052555,
-0.010682454332709312,
0.04081230238080025,
0.055158160626888275,
-0.0037462569307535887,
-0.05113374441862106,
0.00544775603339076,
0.002673572860658169,
-0.06282822042703629,
0.031934916973114014,
-0.007835772819817066,
0.007622715551406145,
0.04905051738023758,
0.005430001299828291,
0.04547588899731636,
0.04355837404727936,
0.035793621093034744,
0.03517812117934227,
-0.022714272141456604,
-0.0322900116443634,
-0.04254043474793434,
0.034799352288246155,
-0.007918628863990307,
0.039060499519109726,
-0.0010556691559031606,
0.016985399648547173,
-0.032574087381362915,
-0.004956540651619434,
-0.015328286215662956,
0.019423721358180046,
0.006089886650443077,
0.03816092386841774,
-0.025353815406560898,
-0.00352728134021163,
0.028005193918943405,
0.015351959504187107,
0.0303251501172781,
0.04602036997675896,
-0.0383976548910141,
0.01717478223145008,
-0.03231368586421013,
0.014795643277466297,
-0.015991130843758583,
0.028170906007289886,
-0.00039652324630878866,
0.014653605408966541,
-0.0853649452328682,
-0.018311088904738426,
0.04789054021239281,
-0.007823936641216278,
-0.05307493358850479,
-0.014914008788764477,
0.042114321142435074,
-0.07130316644906998,
0.03745073452591896,
-0.030798612162470818,
0.026064004749059677,
-0.02734234929084778,
-0.045097120106220245,
-0.05174924433231354,
-0.02158980257809162,
0.03761644288897514,
-0.021613476797938347,
0.014760133810341358,
-0.0015343081904575229,
0.016038477420806885,
-0.023069366812705994,
-0.03127207234501839,
0.0008788612321950495,
-0.0011940083932131529,
-0.010203075595200062,
-0.014641769230365753,
-0.022122446447610855,
0.0066639576107263565,
-0.06315964460372925,
0.014677278697490692,
0.025827275589108467,
0.040362514555454254,
-0.018867405131459236,
-0.005811728537082672,
-0.03638544678688049,
-0.013481790199875832,
0.02007472887635231,
0.02118736132979393,
-0.01761273480951786,
0.03342631831765175,
0.012889964506030083,
-0.024477912113070488,
-0.00983614381402731,
-0.05231739580631256,
0.047369733452796936,
-0.007989647798240185,
-0.009978181682527065,
0.0061017232947051525,
0.005536529701203108,
-0.01081265602260828,
0.029828017577528954,
0.02791050262749195,
0.03908417001366615,
0.0033319788053631783,
-0.028928441926836967,
0.07220274209976196,
0.0719660073518753,
-0.004497875459492207,
0.01705641858279705,
-0.04119107127189636,
-0.00975920632481575,
0.00458073103800416,
0.01249935943633318,
0.02344813570380211,
-0.011244689114391804,
-0.005805810447782278,
-0.011593866162002087,
0.028526000678539276,
0.01132754422724247,
-0.0470619834959507,
0.038066230714321136,
0.02679787017405033,
0.06027153506875038,
0.01145182829350233,
-0.048955824226140976,
0.06775221228599548,
0.04687259718775749,
0.015647873282432556,
0.056389156728982925,
0.016133170574903488,
0.028668038547039032,
-0.0010756432311609387,
-0.009504721499979496,
0.005708159413188696,
-0.016559284180402756,
-0.006368044763803482,
-0.003894213354215026,
-0.02051267959177494,
0.01462993212044239,
0.003583504818379879,
-0.0017044581472873688,
0.015470325015485287,
-0.0038113577757030725,
0.0010660261614248157,
0.017269475385546684,
0.023661192506551743,
-0.03704829141497612,
-0.025898294523358345,
-0.050707630813121796,
-0.01416830811649561,
-0.05004478618502617,
0.010102465748786926,
-0.025306468829512596,
0.01717478223145008,
0.03141411021351814,
-0.0377584807574749,
0.0003728502197191119,
-0.03536750748753548,
0.021530620753765106,
0.004317368846386671,
-0.017470695078372955,
-0.004116148222237825,
0.007871282286942005,
0.011031631380319595,
0.006202333606779575,
-0.002009248360991478,
0.018275579437613487,
0.008173113688826561,
0.007125582080334425,
0.0014470139285549521,
-0.012747926637530327,
0.009439620189368725,
0.006279271095991135,
0.0026069923769682646,
-0.0016186434077098966,
0.02802886627614498,
-0.027200311422348022,
-0.031934916973114014,
-0.017044581472873688,
-0.010901429690420628,
0.021246543154120445,
-0.008830039761960506,
0.02015758492052555,
0.023199569433927536,
-0.03352101147174835,
0.008196786046028137,
0.019139643758535385,
0.02245386876165867,
0.008545964024960995,
-0.042232684791088104,
0.03984170779585838,
-0.025306468829512596,
0.01781395450234413,
0.006687630899250507,
0.0013412251137197018,
0.052648816257715225,
0.00810801237821579,
-0.009978181682527065,
0.0016038477187976241,
-0.013931578025221825,
-0.0007989647565409541,
-0.020737573504447937,
-0.002880711806938052,
-0.005057150963693857,
0.035556890070438385,
-0.011203261092305183,
0.022808963432908058,
-0.04781952127814293,
-0.021447764709591866,
0.00814944040030241,
-0.00114518275950104,
0.02233550325036049,
-0.029520267620682716,
0.04407918080687523,
0.0009520996827632189,
-0.023199569433927536,
-0.025211775675415993,
0.03797154128551483,
-0.003181063337251544,
-0.045144468545913696,
-0.0049328673630952835,
0.0049772546626627445,
-0.04161718487739563,
-0.02933088317513466,
-0.021175524219870567,
-0.020690228790044785,
-0.01355280913412571,
-0.002633624477311969,
-0.004885521251708269,
0.026537466794252396,
-0.010676536709070206,
0.01943555660545826,
0.020441660657525063,
-0.008463107980787754,
-0.0036900334525853395,
0.022560397163033485,
-0.029543941840529442,
-0.005302758421748877,
-0.010481233708560467,
0.005483265500515699,
-0.02897578850388527,
-0.010652863420546055,
-0.030822284519672394,
-0.0027534691616892815,
-0.005788055714219809,
0.005063069052994251,
-0.03652748465538025,
-0.010635108686983585,
-0.032100629061460495,
0.005421123933047056,
0.030301477760076523,
0.016085823997855186,
-0.03811357915401459,
-0.035722602158784866,
-0.006652121432125568,
-0.007101908791810274,
-0.029756998643279076,
0.010001854971051216,
-0.0014950997428968549,
-0.007948219776153564,
-0.01963677816092968,
-0.013600155711174011,
0.018535982817411423,
0.008989833295345306,
-0.03389977663755417,
0.018973933532834053,
0.004358796402812004,
-0.012925473973155022,
0.02078492008149624,
-0.002028482733294368,
-0.005527652334421873,
-0.014476057142019272,
-0.03243204951286316,
0.03295285627245903,
-0.020287785679101944,
-0.0005807289853692055,
0.016594793647527695,
-0.025495853275060654,
-0.0291414987295866,
0.04384244978427887,
0.06723140180110931,
-0.02162531204521656,
0.01896209642291069,
0.008315151557326317,
0.04677790775895119,
-0.02516443096101284,
0.0035095266066491604,
0.002556687220931053,
0.02949659526348114,
0.02106899581849575,
-0.004234513267874718,
0.08763755857944489,
0.01132754422724247,
-0.01152876578271389,
-0.029946383088827133,
-0.0014914008788764477,
0.03764011710882187,
0.012854455038905144,
-0.03610137104988098,
-0.005592753179371357,
-0.01574256457388401,
-0.0027741831727325916,
0.01780211739242077,
-0.021009813994169235,
-0.03610137104988098,
0.009575740434229374,
-0.006510083097964525,
-0.010410214774310589,
-0.006166824139654636,
-0.007894955575466156,
-0.03676421567797661,
0.010522661730647087,
-0.030987996608018875,
-0.02488035336136818,
-0.002988720079883933,
0.022631416097283363,
0.01992085389792919,
-0.011996307410299778,
0.010351032018661499,
-0.02897578850388527,
-0.022004080936312675,
-0.01816905103623867,
-0.014405038207769394,
-0.0034651397727429867,
-0.03252674266695976,
0.021258380264043808,
-0.01099020428955555,
-0.0054891835898160934,
-0.04793788492679596,
0.016843359917402267,
0.03825561702251434,
0.006007031071931124,
-0.03207695484161377,
-0.02802886627614498,
-0.03674054145812988,
-0.0028585183899849653,
-0.006368044763803482,
-0.01404994260519743,
0.0024531176313757896,
0.027295002713799477,
0.0019944526720792055,
-0.009771042503416538,
0.032621435821056366,
-0.017707426100969315,
0.002880711806938052,
0.011534683406352997,
0.007125582080334425,
-0.061076417565345764,
0.032810818403959274,
-0.0009876091498881578,
-0.0025448505766689777,
0.0019071584101766348,
-0.021009813994169235,
-0.021435927599668503,
-0.018512308597564697,
-0.03406548872590065,
0.018027011305093765,
-0.04599669575691223,
0.0020462374668568373,
-0.020181257277727127,
0.0041634938679635525,
0.012688743881881237,
-0.04116739705204964,
-0.05790422856807709,
0.0015964499907568097,
0.012238956056535244,
0.005788055714219809,
0.014961354434490204,
-0.01864251121878624,
0.005107456352561712,
-0.03910784423351288,
-0.013351588509976864,
0.008279642090201378,
-0.015399306081235409,
0.011209179647266865,
0.00041057911585085094,
-0.020406151190400124,
0.011232852935791016,
0.00914370734244585,
-0.0020832265727221966,
-0.03534383326768875,
-0.028573347255587578,
-0.01912780851125717,
0.015458487905561924,
0.01780211739242077,
0.010137975215911865,
0.01880822144448757,
-0.0017710385145619512,
0.017080090939998627,
-0.01570705510675907,
0.018098030239343643,
-0.011144078336656094,
-0.011114487424492836,
0.0010919184423983097,
-0.015813583508133888,
-0.0238505769520998,
0.006924360990524292,
-0.015103393234312534,
-0.010309603996574879,
0.013410771265625954,
0.05482673645019531,
0.017825791612267494,
0.006385799963027239,
0.01844128966331482,
-0.03494139015674591,
0.00878861267119646,
-0.0020861856173723936,
-0.016724996268749237,
0.02344813570380211,
-0.014286673627793789,
-0.01037470530718565,
-0.01721029169857502,
0.06453268229961395,
-0.011221015825867653,
0.028289269655942917,
-0.006385799963027239,
0.009806552901864052,
0.026371754705905914,
-0.08517555892467499,
-0.011120405979454517,
0.007788426708430052,
0.010487152263522148,
-0.006368044763803482,
0.016085823997855186,
-0.007516186684370041,
-0.01305567566305399,
0.02238284982740879,
-0.0056105079129338264,
0.010783065110445023,
-0.03404181823134422,
-0.010220830328762531,
-0.020287785679101944,
0.018535982817411423,
-0.03366304934024811,
-0.02667950466275215,
-0.0464228093624115,
0.007900873199105263,
0.016156842932105064,
-0.00439134705811739,
-0.012712417170405388,
-0.013387097977101803,
0.028407635167241096,
-0.0027401531115174294,
0.012380994856357574,
-0.0011037549702450633,
0.019293518736958504,
-0.028691712766885757,
-0.032739799469709396,
0.0011022754479199648,
-0.01848863624036312,
-0.021530620753765106,
0.043108586221933365,
-0.0028511204291135073,
-0.050470899790525436,
0.028431309387087822,
-0.007782508619129658,
0.006640284787863493,
0.0066225300543010235,
0.021672658622264862,
0.0029339760076254606,
-0.00672905845567584,
0.01041613332927227,
-0.03825561702251434,
0.010078792460262775,
-0.0021690414287149906,
-0.0011414838954806328,
0.011096732690930367,
-0.0031307581812143326,
0.029922708868980408,
-0.04074128344655037,
-0.05894584208726883,
-0.0291414987295866,
0.005669690668582916,
-0.035675257444381714,
-0.0035065675619989634,
0.02734234929084778,
0.028478654101490974,
0.03399446979165077,
-0.05222270265221596,
0.03195859119296074,
0.025377487763762474,
-0.008918814361095428,
-0.01729314774274826,
0.0029842813964933157,
-0.005876829382032156,
0.010469397529959679,
-0.03811357915401459,
-0.025732582435011864,
-0.016050314530730247,
0.0040007419884204865,
-0.0396759994328022,
0.01725763827562332,
0.005258371587842703,
-0.0038350308313965797,
0.00672905845567584,
-0.0034651397727429867,
-0.004190126433968544,
0.028810076415538788,
0.023542828857898712,
0.03688257932662964,
0.01081265602260828,
0.007782508619129658,
-0.006782323122024536,
-0.016914378851652145,
0.023104876279830933,
0.0160976592451334,
0.002775662811473012,
-0.024383220821619034,
0.020725738257169724,
-0.026135025545954704,
-0.03176920488476753,
0.002802294911816716,
-0.04280083626508713,
-0.008297396823763847,
-0.011138160713016987,
0.017506204545497894,
0.0017828750424087048,
0.0002844462578650564,
0.052412088960409164,
-0.03418385609984398,
-0.056625887751579285,
-0.001617163885384798,
-0.03202961012721062,
0.015351959504187107,
0.010966531001031399,
0.004054006189107895,
0.0029872404411435127,
0.018630674108862877,
0.06661590188741684,
0.0016719077248126268,
-0.012073244899511337,
-0.016511937603354454,
-0.025614218786358833,
0.016677649691700935,
0.01749436929821968,
0.003394120605662465,
-0.0024176081642508507,
-0.023128550499677658,
0.06893586367368698,
-0.003337897127494216,
-0.003793603042140603,
0.024383220821619034,
0.00816719513386488,
-0.022406522184610367,
0.02902313508093357,
0.010126138105988503,
-0.03747440502047539,
-0.009196971543133259,
-0.002641022438183427,
0.01788497343659401,
0.006083968561142683,
0.0038379898760467768,
-0.019577596336603165,
0.04419754445552826,
0.03131941705942154,
0.018737202510237694,
-0.015683382749557495,
0.017660079523921013,
0.009392274543642998,
-0.03586464002728462,
0.009930836036801338,
-0.007267619948834181,
0.025330141186714172,
0.001339005772024393,
-0.012357321567833424,
0.0009550587856210768,
0.01524543110281229,
0.017719263210892677,
-0.026584811508655548,
0.011842433363199234,
-0.004107270855456591,
0.04119107127189636,
0.0022430196404457092,
0.024193836376070976,
0.028194578364491463,
-0.014890335500240326,
-0.039060499519109726,
-0.009486966766417027,
0.0051755160093307495,
0.054163891822099686,
-0.0464228093624115,
-0.005231739487498999,
-0.006255598273128271,
-0.006190497428178787,
-0.01749436929821968,
-0.00980063434690237,
0.008581473492085934,
0.036030352115631104,
0.008078421466052532,
-0.037024617195129395,
0.04938194155693054,
-0.004784910939633846,
-0.014215654693543911,
0.022749781608581543,
0.01625153422355652,
0.019660450518131256,
0.02218162827193737,
0.011605702340602875,
-0.034917719662189484,
-0.011729986406862736,
0.02925986424088478,
-0.015008701011538506,
0.04753544181585312,
-0.033165913075208664,
0.0030419842805713415,
-0.02821825072169304,
0.005613467190414667,
-0.01848863624036312,
-0.010611435398459435,
0.008474944159388542,
0.010996121913194656,
0.023791395127773285,
0.029922708868980408,
0.007971893064677715,
-0.04507344961166382,
0.01569521799683571,
-0.039178863167762756,
-0.043274298310279846,
-0.013730357401072979,
0.005208066664636135,
0.0303251501172781,
-0.02221713773906231,
-0.03399446979165077,
0.024110980331897736,
0.006433145608752966,
-0.04057557135820389,
-0.015636036172509193,
0.019849834963679314,
0.016961725428700447,
-0.0017251720419153571,
-0.0403151698410511,
0.01355280913412571,
0.0073859854601323605,
0.0017222128808498383,
0.004861848428845406,
-0.009114116430282593,
-0.03565158322453499,
-0.016405409201979637,
-0.016227861866354942,
-0.0030774937476962805,
0.0008263366762548685,
-0.012120591476559639,
-0.047559116035699844,
-0.0029724447522312403,
0.016760505735874176,
0.018038848415017128,
-0.009096361696720123,
0.022311830893158913,
-0.006057336460798979,
0.01094877626746893,
0.01744702272117138,
0.023826904594898224,
0.005113374441862106,
0.009563904255628586,
-0.03844499960541725,
-0.02158980257809162,
0.024975046515464783,
-0.02002738229930401,
0.0408596508204937,
0.0020699105225503445,
0.003080453025177121,
-0.04313226044178009,
-0.01363566517829895,
-0.006717222277075052,
0.03236103057861328,
-0.02457260526716709,
0.003157390281558037,
0.01606214977800846,
0.012203446589410305,
0.012830781750380993,
0.015754401683807373,
0.00592417549341917,
0.030419843271374702,
0.029188845306634903,
0.010102465748786926,
0.011114487424492836,
-0.006214170251041651,
-0.024619949981570244,
0.022489378228783607,
0.0031928999815136194,
0.013647501356899738,
-0.010137975215911865,
0.01258221548050642,
-0.013398935087025166,
-0.01363566517829895,
-0.0013604593696072698,
0.024229345843195915,
0.0520806647837162,
0.040764957666397095,
0.0030745347030460835,
0.003447385039180517,
-0.0034503440838307142,
0.01757722534239292,
0.0082086231559515,
-0.016606630757451057,
-0.003266878193244338,
-0.006072131916880608,
-0.008717592805624008,
-0.0021690414287149906,
0.02086777612566948,
-0.023590173572301865,
0.015292776748538017,
-0.010783065110445023,
-0.01425116416066885,
-0.012700580060482025,
0.005370818544179201,
0.023365279659628868,
-0.00013306831533554941,
-0.04805624857544899,
0.01307934895157814,
0.002254856051877141,
-0.03576994687318802,
-0.02241835929453373,
-0.004483080003410578,
0.00045570582733489573,
0.020642882212996483,
-0.0015520630404353142,
-0.003832071553915739,
-0.0071137454360723495,
0.012807109393179417,
-0.03562790900468826,
0.007889037020504475,
0.01345811691135168,
-0.03387610614299774,
-0.019542085006833076,
-0.02738969586789608,
0.027673771604895592,
-0.02290365658700466,
-0.018737202510237694,
-0.017837628722190857,
-0.0003530610410962254,
0.0021024609450250864,
0.0086643286049366,
0.013801376335322857,
-0.011724067851901054,
0.022749781608581543,
0.00878269411623478,
0.023164059966802597,
0.005030518863350153,
0.023223241791129112,
0.0020077687222510576,
-0.015588689595460892,
-0.01673683151602745,
-0.02691623382270336,
0.005495102144777775,
-0.005409287288784981,
-0.0033201423939317465,
-0.021838370710611343,
0.049666017293930054,
-0.002821529284119606,
0.02679787017405033,
-0.011522847227752209,
-0.007161091547459364,
-0.008717592805624008,
-0.025259122252464294,
-0.03553321585059166,
-0.012262629345059395,
-0.004764197394251823,
-0.012120591476559639,
0.0017621611477807164,
-0.003583504818379879,
0.020051056519150734,
-0.0034651397727429867,
0.023684866726398468,
-0.0069006881676614285,
-0.014203817583620548,
0.004716851282864809,
0.01264139823615551,
0.04905051738023758,
-0.020145747810602188,
-0.01725763827562332,
0.046091388911008835,
0.010735718533396721,
0.009374519810080528,
0.01089551206678152,
-0.01876087673008442,
0.0010305165778845549,
0.02090328559279442,
-0.014405038207769394,
0.013706684112548828,
-0.006468655541539192,
-0.014061779715120792,
0.005684486124664545,
-0.005666731391102076,
-0.00007665992598049343,
0.026939908042550087,
0.01351729966700077,
-0.029425576329231262,
-0.014369528740644455,
0.02428852766752243,
-0.024110980331897736,
-0.00983614381402731,
-0.0016216025687754154,
0.0038794176653027534,
0.03562790900468826,
0.012913637794554234,
-0.015422978438436985,
0.030774937942624092,
0.03271612524986267,
-0.0007227672031149268,
-0.01041613332927227,
0.002163123106583953,
-0.016511937603354454,
-0.036787886172533035,
-0.01148733776062727,
-0.01955392211675644,
0.0009498803410679102,
0.003447385039180517,
0.006894770078361034,
-0.011457745917141438,
0.002837804378941655,
0.007859446108341217,
-0.014677278697490692,
0.0027667854446917772,
-0.008676165714859962,
-0.0029265782795846462,
0.0001422231289325282,
0.0005973741062916815,
-0.02622971683740616,
0.010096547193825245,
0.03056188113987446,
0.010102465748786926,
0.013351588509976864,
0.00730312941595912,
0.01252303272485733,
-0.010581844486296177,
-0.007551696617156267,
0.0010860002366825938,
-0.018145376816391945,
-0.0049269492737948895,
-0.053122278302907944,
0.03560423478484154,
-0.02015758492052555,
0.004184207879006863,
0.007622715551406145,
0.012179773300886154,
-0.010368786752223969,
0.005068987607955933,
-0.000504161580465734,
0.009167380630970001,
0.02246570587158203,
-0.015482161194086075,
-0.027721118181943893,
0.0303724966943264,
-0.0012199007906019688,
0.0033526928164064884,
-0.04687259718775749,
0.01594378612935543,
0.00981838908046484,
0.008510454557836056,
0.013943414203822613,
-0.027815809473395348,
-0.024454239755868912,
0.024951372295618057,
-0.01031552255153656,
0.01808619499206543,
-0.04190126061439514,
0.004894399084150791,
-0.02615869790315628,
-0.020808592438697815,
0.022394685074687004,
0.014452384784817696,
-0.0000779545443947427,
-0.011747741140425205,
-0.0059803989715874195,
-0.01401443313807249,
-0.008492699824273586,
0.023223241791129112,
0.012866291217505932,
0.030987996608018875,
-0.012783436104655266,
-0.001544665195979178,
-0.018701693043112755,
0.05724138393998146,
-0.01820456050336361,
0.006894770078361034,
0.009498802945017815,
0.018346598371863365,
-0.03148512914776802,
-0.0077055711299180984,
0.01768375374376774,
0.009155544452369213,
-0.005128169897943735,
-0.005891625303775072,
0.0010172005277127028,
0.024667296558618546,
-0.03179287910461426,
0.0025611259043216705,
0.008427598513662815,
0.011937125585973263,
0.010013691149652004,
-0.007841691374778748,
0.015056046657264233,
-0.019033115357160568,
0.02909415401518345,
0.016902543604373932,
0.01626337133347988,
-0.015541343949735165,
-0.01892658695578575,
0.005678568035364151,
0.010984285734593868,
0.013245060108602047,
0.004793788306415081,
0.031106360256671906,
-0.0029872404411435127,
-0.0346573144197464,
0.050897013396024704,
0.017151109874248505,
-0.003769929986447096,
-0.0029280579183250666,
-0.0005651935935020447,
-0.007202519103884697,
-0.0076759797520935535,
0.010025528259575367,
-0.008954323828220367,
0.015067883767187595,
-0.016109496355056763,
-0.00017708535597193986,
0.013422607444226742,
0.04317960515618324,
-0.0012524512130767107,
0.018855568021535873,
-0.003488812828436494,
-0.019707797095179558,
-0.041522495448589325,
-0.07002481818199158,
0.01729314774274826,
-0.008652492426335812,
-0.040291495621204376,
-0.026726851239800453,
0.01522175781428814,
0.012215283699333668,
0.02270243503153324,
-0.024738315492868423,
-0.0321953184902668,
0.024833008646965027,
0.008326987735927105,
-0.021814696490764618,
-0.017873138189315796,
0.01206140872091055,
0.013907904736697674,
-0.01852414570748806,
0.0022948042023926973,
0.013825049623847008,
-0.022252647206187248,
0.032218992710113525,
-0.017482532188296318,
-0.0028614774346351624,
0.023471808061003685,
-0.0017133355140686035,
0.003021270502358675,
-0.038705404847860336,
-0.00168226461391896,
0.008711675181984901,
-0.038539692759513855,
-0.02114001475274563,
-0.005725914146751165,
-0.03934457525610924,
-0.028478654101490974,
-0.01522175781428814,
0.006758649833500385,
0.007723325863480568,
0.0303251501172781,
0.03361570090055466,
0.041120052337646484,
-0.03898948058485985,
-0.0006066213827580214,
0.030822284519672394,
-0.017399676144123077,
-0.0064153908751904964,
0.012653234414756298,
0.007930465042591095,
-0.005743668880313635,
-0.003491771873086691,
0.026726851239800453,
-0.027081945911049843,
-0.020287785679101944,
-0.012167937122285366,
0.020773082971572876,
0.00968226883560419,
0.024099143221974373,
0.04571262001991272,
0.014842989854514599,
-0.024619949981570244,
-0.03470466285943985,
-0.02440689317882061,
-0.014700951054692268,
-0.008001483976840973,
-0.005921216681599617,
-0.0011755138402804732,
-0.013375261798501015,
0.0006132794078439474,
-0.016985399648547173,
0.01702090911567211,
0.004326246213167906,
0.012345485389232635,
0.012972820550203323,
0.018109867349267006,
-0.002530055120587349,
0.03141411021351814,
-0.006072131916880608,
0.003953395877033472,
-0.046683214604854584,
-0.012724253349006176,
-0.004119107034057379,
0.03659850358963013,
-0.015257267281413078,
-0.016760505735874176,
-0.0477011539041996,
0.011090814135968685,
0.05359574034810066,
-0.006190497428178787,
-0.025022393092513084,
0.038018885999917984,
-0.034680988639593124,
0.022406522184610367,
-0.04291920363903046,
0.02738969586789608,
0.0032254501711577177,
0.04429223760962486,
-0.002910303184762597,
-0.022015918046236038,
0.012156100943684578,
-0.030301477760076523,
0.009155544452369213,
-0.022323666140437126,
-0.018074357882142067,
0.011647130362689495,
-0.03247939795255661,
0.02051267959177494,
0.013718520291149616,
0.00868800189346075,
0.0023066408466547728,
0.01805068552494049,
-0.04947663098573685,
-0.0031041260808706284,
0.020962467417120934,
-0.006255598273128271,
0.017790282145142555,
0.029946383088827133,
-0.011540601961314678,
-0.03354468196630478,
0.02779213711619377,
0.014369528740644455,
0.03311856836080551,
0.003941559232771397,
0.05425858497619629,
0.0031751450151205063,
-0.006397636141628027,
0.019222499802708626,
-0.005015722941607237,
-0.006646202877163887,
0.008196786046028137,
0.0056608133018016815,
-0.022169793024659157,
0.012747926637530327,
-0.03664584830403328,
0.005033478140830994,
-0.00024727219715714455,
0.002189755206927657,
-0.0007863884675316513,
0.005228780210018158,
-0.004787870217114687,
0.02698725461959839,
0.004710932727903128,
-0.015422978438436985,
-0.01757722534239292,
0.007232110481709242,
-0.01416830811649561,
0.023483645170927048,
0.02115185186266899,
0.00878269411623478,
0.02261957898736,
-0.009191053919494152,
0.005512856878340244,
0.0033290197607129812,
-0.01928168348968029,
-0.0024042921140789986,
0.006125396583229303,
-0.015565017238259315,
-0.005808769725263119,
0.035911984741687775,
0.02511708438396454,
-0.005601630546152592,
0.007101908791810274,
0.04419754445552826,
-0.02047717012465,
-0.007936383597552776,
-0.023684866726398468,
0.0161450058221817,
0.02218162827193737,
-0.012345485389232635,
0.13067512214183807,
-0.03681156039237976,
-0.01244017668068409,
-0.033734068274497986,
0.00920289009809494,
-0.03124839998781681,
0.03143778443336487,
0.014842989854514599,
0.0036101369187235832,
-0.0303724966943264,
0.01091326680034399,
0.016239698976278305,
0.05766750127077103,
0.032621435821056366,
0.0471566766500473,
-0.0024161285255104303,
-0.004169412422925234,
0.02786315605044365,
0.001639357302337885,
0.001741447253152728,
0.01246384996920824,
0.01029184926301241,
-0.022927328944206238,
0.03773481026291847,
-0.011173670180141926,
0.0036101369187235832,
-0.019624941051006317,
-0.022252647206187248,
-0.00047641972196288407,
-0.016559284180402756,
0.00807250291109085,
0.025424834340810776,
0.017340494319796562,
-0.029828017577528954,
-0.023033857345581055,
-0.04197228327393532,
-0.009575740434229374,
-0.03974701836705208,
-0.013351588509976864,
0.016275208443403244,
0.022951001301407814,
0.009522476233541965,
-0.0036604423075914383,
0.013233223930001259,
0.02587462216615677,
0.02615869790315628,
-0.036787886172533035,
0.0023347525857388973,
-0.002592196688055992,
-0.03295285627245903,
0.0010260778944939375,
0.008504536002874374,
0.02047717012465,
-0.031461454927921295,
-0.032218992710113525,
-0.008084340021014214,
0.011422236450016499,
0.007522105239331722,
0.014558913186192513,
-0.01419198140501976,
0.013730357401072979,
0.041830241680145264,
-0.008510454557836056,
0.01824006997048855,
0.025022393092513084
] | 2025-01-03 | 83 | 39747173 | [
"immunosuppressive cell populations",
"STING agonists",
"Internalized STING agonists",
"solid tumors",
"tumor growth",
"CAR-T cell activity",
"CAR-T cell exhaustion",
"STING",
"CAR-T cells",
"CAR-T cell infiltration",
"poor cellular uptake",
"pulmonary delivery",
"myeloid-derived suppressor cells",
"an effective CAR-T cell enhancer",
"aPD-L1 NVs@cGAMP",
"the immunosuppressive tumor microenvironment",
"the anti-PD-L1 single chain variable fragment",
"the STING agonist cGAMP",
"PD-L1 upregulation",
"combined therapy",
"interferon responses",
"PD-L1-overexpressing cells",
"the tumor microenvironment",
"both orthotopic lung cancer and lung metastasis model",
"CAR-T",
"an anti-PD-L1-expressing nanovesicle",
"PD-1",
"myeloid",
"the PD-1/PD-L1 interaction",
"Suppression"
] | [] | 0 | 10.1038/s41467-024-55751-4 | [
"Zhu",
"Xiao",
"Chen",
"Ding",
"Chen",
"Jiang",
"Huang"
] | [
"Center for Infection and Immunity, Guangdong Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.",
"Center for Infection and Immunity, Guangdong Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.",
"Center for Infection and Immunity, Guangdong Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.",
"Center for Infection and Immunity, Guangdong Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China.",
"Guangdong Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China. [email protected].",
"Department of Clinical laboratory, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, 519000, China. [email protected].",
"Center for Infection and Immunity, Guangdong Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, 519000, Guangdong, China. [email protected]."
] | [
"39747173",
"35417527",
"36418477",
"36813894",
"37904019",
"33972771",
"38167707",
"37938576",
"31296767",
"37872225",
"34613775",
"33469002",
"35379957",
"35443752",
"37857711",
"34385695",
"30102295",
"38440217",
"38448658",
"37500747",
"37443252",
"33827917",
"33382402",
"36638189",
"36442099",
"36959214",
"36510011",
"36921054",
"37221157",
"38480836",
"37884660",
"35410368",
"37291242",
"37945606",
"37328484",
"38336902",
"36814099",
"36442821",
"37308954",
"37624742",
"34194679",
"38212521",
"21053952",
"35108018",
"34711143",
"33345422",
"32424363",
"38512518",
"33711340",
"33888863",
"37250173",
"34429860",
"38730243",
"34810235",
"35931610",
"26999211",
"34012451",
"32680511",
"26583099",
"31889162",
"37413990",
"29534457",
"31990272",
"18432774",
"33545064",
"37563723",
"35301179",
"38168996",
"37696984",
"35697686",
"37723642",
"37524727",
"37703879",
"37384818",
"38193813",
"36528193",
"37409429",
"33537081",
"35597405",
"22330761",
"36240777",
"33462245",
"31999649"
] | [] | 10.169621 | 3.755513 |
39746895 | 87 | Co-Expression of Dominant-Negative TGF-β Receptor 2 Enhances the Therapeutic Efficacy of Novel TREM1/DAP12-BB-Based CAR-T Cells in Solid Tumours. | Chimeric antigen receptor (CAR) T-cell therapy has exhibited remarkable efficacy in the treatment of haematological malignancies, yet its application in solid tumours is hindered by the immunosuppressive tumour microenvironment (TME). In this study, a novel SS1-TREM1/DAP12-BB CAR-T cell was devised to target ovarian cancer and further engineered to co-express the dominant-negative TGF-β receptor 2 (DNR) to combat CAR-T cell exhaustion in TME. The incorporation of DNR effectively blocked TGF-β signalling, thereby enhancing CAR-T cell survival and antitumor activity in a TGF-β1-rich environment. In vivo evaluations demonstrated that DNR co-expression potentiated the antitumor efficacy of TREM1/DAP12-BB CAR-T cells and conferred resilience against tumour rechallenge. These findings underscore the broad potential of DNR co-expression in CAR design, presenting a novel therapeutic strategy for patients with recurrent ovarian cancer. | [
0.05341605097055435,
0.01158243790268898,
0.050483789294958115,
0.05282960087060928,
-0.040856193751096725,
-0.00864406581968069,
0.040807321667671204,
-0.0003768415772356093,
-0.018595432862639427,
-0.0123399393633008,
-0.02178426831960678,
-0.0010889079421758652,
-0.03704425320029259,
0.01318296417593956,
0.04305539280176163,
-0.010794391855597496,
0.06138203293085098,
0.003863867139443755,
0.024117860943078995,
0.04395950585603714,
0.02724560722708702,
0.010214048437774181,
-0.006713659968227148,
-0.025339636951684952,
-0.018387731164693832,
0.0023748273961246014,
0.02474096603691578,
0.022334067150950432,
0.004596932791173458,
-0.04391063377261162,
0.01792345568537712,
-0.032474808394908905,
-0.028687303885817528,
-0.004725219216197729,
0.0255595576018095,
0.012620947323739529,
0.02430112659931183,
0.010116306133568287,
-0.020855719223618507,
-0.02748996391892433,
0.054588958621025085,
0.01787458546459675,
0.013378448784351349,
0.10800500959157944,
-0.07433286309242249,
0.02142995409667492,
-0.025877218693494797,
-0.043202005326747894,
0.039561111479997635,
-0.001988440752029419,
0.006255493964999914,
0.012492661364376545,
-0.03042222559452057,
0.06289703398942947,
-0.08005077391862869,
0.021686526015400887,
-0.040000949054956436,
0.03245037421584129,
0.02573060616850853,
0.003631729632616043,
-0.020208178088068962,
0.011722941882908344,
0.037875059992074966,
-0.015027846209704876,
-0.041906923055648804,
-0.010372878983616829,
-0.07213366031646729,
-0.016115227714180946,
0.036164574325084686,
0.022138584405183792,
0.01662837341427803,
-0.018351078033447266,
0.0069824508391320705,
-0.0231404397636652,
0.06519397348165512,
-0.01632292941212654,
0.02250511571764946,
0.02114894427359104,
-0.011765704490244389,
-0.00398604478687048,
0.012730907648801804,
0.007379527669399977,
0.007959871552884579,
-0.03450295701622963,
0.005345270503312349,
-0.04630531370639801,
-0.026536976918578148,
-0.04691620543599129,
-0.02338479459285736,
0.0027199790347367525,
-0.02915157936513424,
0.0029368444811552763,
-0.0026909620501101017,
0.040636274963617325,
-0.0030376408249139786,
0.03372102230787277,
-0.023751327767968178,
-0.06284816563129425,
0.008326404727995396,
0.05419798940420151,
0.0007594102062284946,
-0.01809450425207615,
-0.011008203029632568,
0.03692207485437393,
0.01638401858508587,
-0.019414022564888,
-0.04889548197388649,
-0.017446963116526604,
0.010562255047261715,
0.010250701569020748,
0.08122367411851883,
-0.017227044329047203,
0.0030132054816931486,
0.02294495515525341,
0.002167125465348363,
-0.06138203293085098,
-0.01348840817809105,
0.006518175825476646,
-0.006298256106674671,
0.00734287453815341,
-0.04564555734395981,
0.012510987929999828,
0.018815351650118828,
0.015101153403520584,
0.0023900994565337896,
-0.02504641003906727,
0.06128429248929024,
-0.027709882706403732,
-0.036164574325084686,
-0.038021672517061234,
0.029518110677599907,
0.025412943214178085,
-0.00598364882171154,
-0.03491836041212082,
-0.04828459396958351,
0.008546324446797371,
-0.06480300426483154,
-0.00528723606839776,
0.004147930070757866,
0.006469304673373699,
0.004926812369376421,
-0.025266330689191818,
-0.02294495515525341,
-0.002900191117078066,
-0.0246798787266016,
-0.056739285588264465,
-0.02529076673090458,
0.026536976918578148,
-0.0014707130612805486,
0.030324483290314674,
-0.0020144034642726183,
0.02790536731481552,
0.041882485151290894,
0.006780857685953379,
0.01894974708557129,
-0.05087475851178169,
0.0004493845335673541,
0.045572251081466675,
-0.02197975292801857,
-0.06265267729759216,
-0.021857574582099915,
0.005882852245122194,
-0.028809480369091034,
-0.022993827238678932,
0.04351966455578804,
-0.00270623411051929,
0.00733676552772522,
0.0004066223627887666,
-0.06353235989809036,
0.010049108415842056,
0.015467685647308826,
-0.014893450774252415,
-0.0710584968328476,
0.008338621817529202,
-0.06270155310630798,
0.012950827367603779,
0.0119550796225667,
0.03323231264948845,
-0.027343349531292915,
-0.01395268365740776,
-0.005317780654877424,
0.030788758769631386,
0.03770401328802109,
0.010513383895158768,
-0.01803341507911682,
0.0024664606899023056,
-0.02658584900200367,
0.013671674765646458,
-0.03110641986131668,
0.013720545917749405,
-0.010617234744131565,
-0.0012614838778972626,
0.0241300780326128,
0.011722941882908344,
0.022334067150950432,
-0.026341494172811508,
0.036531105637550354,
0.021637655794620514,
-0.015296637080609798,
-0.005189494229853153,
0.0451812818646431,
-0.006139425095170736,
-0.003019314259290695,
-0.009474873542785645,
-0.01855877973139286,
-0.01855877973139286,
-0.007434507831931114,
0.004175419919192791,
-0.02121003344655037,
0.011020421050488949,
0.05141234025359154,
0.0018861169228330255,
0.0070313215255737305,
0.011380844749510288,
-0.003139964770525694,
-0.03579803928732872,
0.020867936313152313,
0.028882788494229317,
0.044717006385326385,
0.009700902737677097,
-0.01750805228948593,
-0.01563873514533043,
-0.0359690897166729,
0.019866079092025757,
-0.030324483290314674,
0.0068602729588747025,
0.024398868903517723,
-0.006933579687029123,
0.0010614179773256183,
-0.02123446948826313,
-0.008387492969632149,
0.00922441016882658,
0.009523744694888592,
-0.02121003344655037,
0.0004554934275802225,
0.0005860707606188953,
0.022773906588554382,
-0.019597290083765984,
0.03450295701622963,
-0.003411809913814068,
-0.021381082013249397,
0.035455942153930664,
0.04207796975970268,
-0.018045634031295776,
-0.0004085313994437456,
-0.01783793233335018,
-0.006179132964462042,
-0.06783301383256912,
-0.006890817545354366,
-0.009792535565793514,
0.013427319936454296,
0.0003329339961055666,
0.010965440422296524,
-0.012791995890438557,
-0.0010125469416379929,
0.02641480043530464,
0.013280706480145454,
0.02485092729330063,
-0.011979514732956886,
-0.023335924372076988,
-0.002341228537261486,
-0.00995747558772564,
-0.02399568259716034,
-0.031619567424058914,
-0.032670293003320694,
-0.014331433922052383,
0.02057470940053463,
-0.0019197157816961408,
0.05234089121222496,
0.013549497351050377,
0.04591434821486473,
-0.0313752107322216,
0.01963394321501255,
0.018302205950021744,
-0.07443059980869293,
0.036360058933496475,
-0.0029750249814242125,
0.021686526015400887,
0.0066464622505009174,
-0.0042212363332509995,
-0.002376354532316327,
0.017055995762348175,
0.00383026828058064,
0.00422734534367919,
-0.021552130579948425,
-0.013097439892590046,
0.015565427951514721,
0.04024530574679375,
-0.0035950762685388327,
-0.02641480043530464,
-0.0025290765333920717,
-0.003769179340451956,
-0.01872982829809189,
-0.011600764468312263,
-0.05033717676997185,
0.004890158772468567,
-0.011167033575475216,
-0.04344635829329491,
-0.0017822659574449062,
0.007275676820427179,
-0.04432603716850281,
0.056055087596178055,
-0.01809450425207615,
-0.017337003722786903,
0.004144875332713127,
-0.011295320466160774,
0.01158243790268898,
-0.029029401019215584,
0.032010532915592194,
0.04948193207383156,
0.04481474682688713,
-0.035480380058288574,
0.02112451009452343,
0.04808910936117172,
-0.0008231716929003596,
0.01665280945599079,
0.03767957538366318,
-0.049897339195013046,
0.02162543684244156,
-0.054540086537599564,
-0.043421924114227295,
-0.03413642570376396,
-0.06069783866405487,
0.006243275944143534,
0.012730907648801804,
-0.02485092729330063,
0.026952382177114487,
-0.005430794786661863,
0.01679942198097706,
-0.03797280415892601,
-0.00012437299301382154,
-0.04542563855648041,
0.056690413504838943,
0.012510987929999828,
-0.0032896322663873434,
-0.0007265749736689031,
-0.03709312528371811,
-0.037875059992074966,
0.03328118100762367,
0.005348325241357088,
0.0005700349574908614,
0.020611362531781197,
-0.041906923055648804,
0.04263998568058014,
0.00280550355091691,
0.0012683563400059938,
-0.0017746298108249903,
-0.00966424960643053,
-0.0019013890996575356,
0.05884074047207832,
0.005085643380880356,
0.010995985008776188,
0.03411199152469635,
-0.007703298702836037,
-0.0053513795137405396,
0.02228519693017006,
-0.017740190029144287,
-0.01792345568537712,
0.012987480498850346,
-0.001030873623676598,
-0.0015295109478756785,
0.017532488331198692,
-0.04432603716850281,
0.0412471629679203,
0.051558952778577805,
0.06607365608215332,
-0.042566679418087006,
0.05551750585436821,
-0.03489392623305321,
-0.016151880845427513,
-0.026536976918578148,
0.02068467065691948,
0.02211414836347103,
0.029444804415106773,
-0.02981133759021759,
0.050483789294958115,
0.018656522035598755,
0.04488805681467056,
0.023433666676282883,
-0.013121875934302807,
0.049872901290655136,
-0.014148167334496975,
-0.013561715371906757,
-0.02259064093232155,
-0.016457324847579002,
0.017581358551979065,
0.05683702602982521,
-0.03650667145848274,
-0.0677841380238533,
0.008717373013496399,
0.01227274164557457,
-0.0357491709291935,
0.02617044560611248,
-0.0015150024555623531,
-0.02360471524298191,
0.04444821551442146,
-0.039805468171834946,
0.0636301040649414,
0.07535915076732635,
0.013476191088557243,
0.0029490620363503695,
-0.047062817960977554,
-0.023849070072174072,
-0.010965440422296524,
0.026292622089385986,
-0.01427034568041563,
0.06328800320625305,
-0.02548624947667122,
0.029909079894423485,
-0.009450438432395458,
-0.041735872626304626,
-0.0015402015997096896,
0.03645779937505722,
-0.009804753586649895,
0.014392523095011711,
-0.00503371749073267,
-0.015516556799411774,
0.036946509033441544,
-0.038681432604789734,
0.05727686360478401,
0.018961966037750244,
-0.01715373620390892,
0.027563270181417465,
-0.0015867818146944046,
0.011148707009851933,
0.02068467065691948,
0.02768544666469097,
-0.0019746955949813128,
0.007880455814301968,
-0.05986703187227249,
-0.01114259846508503,
0.06309252232313156,
0.015492121689021587,
0.004862668924033642,
-0.007300112396478653,
0.04530346021056175,
-0.036579977720975876,
0.0269768163561821,
-0.03474731370806694,
0.03572473302483559,
-0.01883978769183159,
-0.0024130078963935375,
-0.006298256106674671,
-0.03281690552830696,
0.02504641003906727,
-0.0011179251596331596,
-0.0028238301165401936,
0.01362280361354351,
-0.03242594003677368,
-0.013329577632248402,
-0.026683591306209564,
0.01033011730760336,
-0.01676276884973049,
0.02241959236562252,
-0.02768544666469097,
-0.011930643580853939,
0.04293321445584297,
-0.031839486211538315,
0.002648199675604701,
0.025608427822589874,
0.04415499046444893,
-0.04525458812713623,
0.02683020383119583,
-0.027318913489580154,
0.009658140130341053,
0.028589561581611633,
0.0100918710231781,
-0.02912714332342148,
0.024716531857848167,
-0.032303761690855026,
-0.016530631110072136,
0.03958554565906525,
-0.026317058131098747,
0.0293959341943264,
-0.006958015263080597,
0.0184243842959404,
0.017312567681074142,
0.009816971607506275,
0.017165955156087875,
0.02222410775721073,
-0.007385636679828167,
-0.012791995890438557,
-0.03496723249554634,
-0.012950827367603779,
0.031595129519701004,
0.051998794078826904,
0.002764268545433879,
-0.0015531829558312893,
-0.03814385086297989,
0.02255398780107498,
0.004190692212432623,
0.0011286156950518489,
0.01662837341427803,
-0.01183290220797062,
-0.015516556799411774,
0.004740491509437561,
0.049652982503175735,
0.0018387731397524476,
-0.010800501331686974,
0.007746060844510794,
0.019145231693983078,
0.03987877443432808,
0.0138182882219553,
0.002144217025488615,
0.040147565305233,
0.02211414836347103,
-0.0024130078963935375,
0.03841264173388481,
0.009407675825059414,
-0.007819367572665215,
-0.022346286103129387,
-0.01745918020606041,
0.03110641986131668,
-0.005372760351747274,
-0.03499166667461395,
-0.014514700509607792,
-0.04938419163227081,
-0.031863920390605927,
-0.03086206503212452,
-0.02978690154850483,
-0.009511527605354786,
-0.011729051358997822,
-0.01792345568537712,
0.030324483290314674,
0.011191469617187977,
-0.021820921450853348,
-0.012791995890438557,
-0.057032510638237,
-0.02548624947667122,
-0.034185297787189484,
0.011808466166257858,
-0.014160385355353355,
0.014624659903347492,
0.05063040181994438,
-0.008552432991564274,
-0.04735604301095009,
-0.024472175166010857,
0.03069101646542549,
-0.00858908612281084,
-0.03919458016753197,
0.03364771604537964,
0.0014699493767693639,
0.007935436442494392,
-0.02454548329114914,
0.01897418312728405,
0.010818827897310257,
-0.004410611931234598,
-0.008228662423789501,
0.013610586524009705,
-0.026927946135401726,
0.012242197059094906,
-0.028687303885817528,
0.02474096603691578,
0.008002633228898048,
0.011906208470463753,
-0.007330656982958317,
-0.011081509292125702,
-0.019572854042053223,
0.025657298043370247,
-0.013781635090708733,
-0.027318913489580154,
0.006426542531698942,
0.01113038044422865,
-0.031130855903029442,
-0.03274359926581383,
-0.0035034429747611284,
-0.022297414019703865,
-0.0030254232697188854,
-0.06201735511422157,
0.021686526015400887,
-0.018925312906503677,
0.00577900093048811,
-0.007000777404755354,
-0.012816431932151318,
0.03174174576997757,
0.015736477449536324,
0.005162004381418228,
0.009120559319853783,
0.004157093353569508,
-0.004114331211894751,
-0.019145231693983078,
-0.008020960725843906,
-0.008265315555036068,
0.031399644911289215,
-0.036115702241659164,
0.016445105895400047,
-0.03220601752400398,
-0.016469541937112808,
-0.029224885627627373,
0.007446725387126207,
0.020428096875548363,
-0.005687368102371693,
0.051998794078826904,
0.015247765928506851,
-0.03303682804107666,
0.006719768978655338,
0.01002467330545187,
0.009364914149045944,
-0.02197975292801857,
0.020586928352713585,
0.0111853601410985,
-0.03237706795334816,
0.016994906589388847,
-0.03919458016753197,
-0.014624659903347492,
0.007978198118507862,
0.024533264338970184,
-0.023042697459459305,
0.003173563629388809,
0.001146942377090454,
0.013793852180242538,
0.03315900266170502,
0.011802357621490955,
-0.00043678496149368584,
0.0092121921479702,
0.002283194102346897,
-0.0313752107322216,
-0.01075773872435093,
0.00889453012496233,
-0.032279323786497116,
-0.020232612267136574,
-0.0040501877665519714,
-0.029200449585914612,
0.00007526332046836615,
-0.024252256378531456,
-0.025657298043370247,
-0.013757199048995972,
-0.003089566482231021,
0.011869555339217186,
0.0013164638075977564,
0.011167033575475216,
-0.051558952778577805,
-0.019682813435792923,
0.016200751066207886,
-0.019597290083765984,
-0.024398868903517723,
0.03298795595765114,
-0.02090458944439888,
-0.014197038486599922,
-0.025217458605766296,
-0.02832077071070671,
0.02399568259716034,
0.00772773427888751,
-0.007080192677676678,
0.02153991349041462,
-0.006402106955647469,
-0.010476730763912201,
0.000006735279384884052,
0.004181528929620981,
-0.01690938137471676,
-0.03714199364185333,
-0.02263951115310192,
0.010831044986844063,
0.01427034568041563,
0.018595432862639427,
-0.0009331315523013473,
0.013305142521858215,
0.015895307064056396,
0.049433063715696335,
0.076336570084095,
-0.034845054149627686,
0.021478824317455292,
-0.021943099796772003,
-0.006958015263080597,
-0.009071688167750835,
0.013549497351050377,
-0.01563873514533043,
-0.0009529853705316782,
0.02915157936513424,
0.011215904727578163,
0.1283353716135025,
-0.024117860943078995,
0.018961966037750244,
0.001531038200482726,
0.03091093711555004,
0.019511764869093895,
0.001814337563700974,
-0.020672451704740524,
-0.028638431802392006,
0.02507084608078003,
0.0076116654090583324,
0.007006885949522257,
0.0016921599162742496,
-0.043202005326747894,
-0.006197459530085325,
-0.011839010752737522,
-0.017642447724938393,
-0.00015873544907663018,
0.01087991613894701,
-0.0004776380956172943,
-0.002438970608636737,
-0.03044666163623333,
-0.015137806534767151,
-0.028125286102294922,
0.02683020383119583,
0.0036897638346999884,
-0.000013649530046677683,
0.0006521230097860098,
-0.01621297001838684,
-0.0240201186388731,
0.02349475584924221,
0.04009869322180748,
0.0016417616279795766,
-0.012510987929999828,
0.03609126806259155,
-0.012865303084254265,
0.0030025148298591375,
-0.01787458546459675,
0.022053059190511703,
0.040831759572029114,
0.03391650691628456,
-0.020403660833835602,
-0.03851038217544556,
-0.008387492969632149,
-0.0027459419798105955,
0.02195531688630581,
-0.011906208470463753,
0.051998794078826904,
-0.012388809584081173,
0.04799136519432068,
0.010727194137871265,
0.03489392623305321,
-0.012804213911294937,
-0.0296158529818058,
0.05781444534659386,
0.013769417069852352,
-0.05356266722083092,
0.03147295489907265,
-0.021772051230072975,
0.015259983949363232,
-0.0009995655855163932,
-0.023531408980488777,
0.009120559319853783,
-0.005430794786661863,
-0.048137981444597244,
0.02219967171549797,
-0.00002051008959824685,
-0.01544325053691864,
-0.002325956244021654,
-0.001209558336995542,
0.05473557114601135,
-0.028565125539898872,
-0.018961966037750244,
-0.012333829887211323,
0.012248305603861809,
0.03567586466670036,
0.007953763008117676,
0.008320295251905918,
0.002454242901876569,
-0.009169429540634155,
0.002946007763966918,
0.009517636150121689,
-0.017092648893594742,
0.0049573564901947975,
-0.0193040631711483,
-0.03792393207550049,
-0.0011484695132821798,
0.010537819005548954,
-0.0548333115875721,
0.004706892650574446,
-0.023787980899214745,
0.014197038486599922,
0.014111514203250408,
0.009810862131416798,
0.003350720973685384,
0.016665026545524597,
0.024411087855696678,
0.015382161363959312,
-0.015369943343102932,
0.02912714332342148,
-0.028833916410803795,
-0.03306126222014427,
-0.013964901678264141,
-0.017727971076965332,
0.021613219752907753,
0.026634719222784042,
-0.03435634449124336,
0.03626231476664543,
-0.003152182325720787,
0.037435222417116165,
-0.01126477587968111,
0.012126128189265728,
-0.012291068211197853,
0.02890722267329693,
-0.0031033114064484835,
-0.029933515936136246,
0.001899861847050488,
0.01985386200249195,
-0.02305491641163826,
-0.0017669937806203961,
-0.03088650107383728,
0.02810085192322731,
-0.02917601354420185,
0.04315313324332237,
0.005855361931025982,
0.02463100664317608,
0.010201830416917801,
-0.09446772933006287,
-0.03609126806259155,
-0.00976199097931385,
-0.006365453824400902,
-0.008699046447873116,
0.009432111866772175,
-0.014050425961613655,
-0.04176030680537224,
-0.005876743234694004,
-0.0016875782748684287,
-0.032279323786497116,
-0.0191941037774086,
0.004563333932310343,
-0.018265552818775177,
0.012889738194644451,
-0.0075261411257088184,
-0.012443790212273598,
-0.027709882706403732,
0.0026314002461731434,
0.04830902814865112,
0.004728273488581181,
-0.023458102717995644,
0.008289750665426254,
0.06856607645750046,
-0.00691525312140584,
0.005986703094094992,
0.005326943937689066,
-0.020061563700437546,
-0.05102137103676796,
-0.029469240456819534,
0.0038913569878786802,
0.02013486996293068,
-0.02898053079843521,
0.041735872626304626,
-0.021637655794620514,
-0.06309252232313156,
0.03091093711555004,
-0.009144994430243969,
-0.00015959450684022158,
0.013134093023836613,
0.023103786632418633,
-0.016457324847579002,
0.026952382177114487,
-0.00969479326158762,
-0.028198592364788055,
-0.013635021634399891,
-0.007513923104852438,
-0.013354012742638588,
-0.015211112797260284,
-0.013916030526161194,
0.029298191890120506,
-0.028271900489926338,
-0.02123446948826313,
-0.016555067151784897,
-0.018790917471051216,
-0.006548719946295023,
0.013989336788654327,
0.0383882075548172,
0.0119550796225667,
-0.004031861200928688,
-0.016041921451687813,
0.037655141204595566,
0.04415499046444893,
0.013170747086405754,
-0.022431809455156326,
-0.00925495382398367,
-0.011490804143249989,
0.024178950116038322,
-0.04613426700234413,
-0.0011805412359535694,
-0.02369023859500885,
0.006234112661331892,
-0.04698951169848442,
0.024973103776574135,
-0.016115227714180946,
-0.029762467369437218,
-0.0193040631711483,
0.021381082013249397,
0.004755763802677393,
-0.0017776843160390854,
0.00523225637152791,
-0.024056771770119667,
-0.04415499046444893,
0.004187637474387884,
-0.0011820683721452951,
0.006166914943605661,
-0.02898053079843521,
0.031008677557110786,
0.018045634031295776,
-0.0006070699892006814,
-0.003775288350880146,
-0.02101454883813858,
-0.02641480043530464,
-0.0201837420463562,
0.008925074711441994,
-0.001194286160171032,
-0.04415499046444893,
-0.008662392385303974,
-0.0026039103977382183,
-0.012223870493471622,
0.04845564067363739,
-0.028785046190023422,
-0.03108198568224907,
-0.011930643580853939,
-0.023641368374228477,
0.003818050492554903,
0.07144946604967117,
0.00517116766422987,
-0.010605016723275185,
-0.01792345568537712,
0.02430112659931183,
-0.01618853397667408,
0.026488106697797775,
-0.008674610406160355,
0.009462656453251839,
0.019242973998188972,
0.050728145986795425,
-0.01424590963870287,
0.009798645041882992,
0.004511408507823944,
0.05893848091363907,
-0.0071534994058310986,
-0.0032377068419009447,
-0.01438030507415533,
0.007318438962101936,
-0.017642447724938393,
0.00691525312140584,
-0.00841192901134491,
-0.004483918193727732,
0.01695825345814228,
-0.0029597526881843805,
0.01662837341427803,
-0.01583421789109707,
0.022871648892760277,
-0.013744981959462166,
0.0287361741065979,
0.032034970819950104,
0.03689764067530632,
0.005595734808593988,
0.01787458546459675,
-0.015626516193151474,
0.008967836387455463,
-0.013989336788654327,
-0.04865112528204918,
0.018021197989583015,
-0.0030880391132086515,
-0.0458410419523716,
0.028027543798089027,
0.010311790741980076,
-0.010085761547088623,
-0.01800898090004921,
0.017117083072662354,
0.024398868903517723,
0.04251781105995178,
0.03069101646542549,
0.030984243378043175,
0.02456991747021675,
-0.017886802554130554,
-0.04369071498513222,
-0.013109657913446426,
-0.03946337103843689,
0.039341192692518234,
-0.02369023859500885,
-0.04505910351872444,
0.047038380056619644,
-0.00894950982183218,
-0.0005700349574908614,
-0.003369047772139311,
0.0184243842959404,
0.01318296417593956,
0.010299572721123695,
-0.03455182909965515,
0.02241959236562252,
0.006921361666172743,
-0.02217523753643036,
-0.012095583602786064,
0.0007353565306402743,
0.029469240456819534,
0.014343651942908764,
0.0185343436896801,
-0.02705012448132038,
-0.0073489835485816,
0.03364771604537964,
0.02118559740483761,
0.030519967898726463,
-0.012657600454986095,
-0.01394046563655138,
-0.03066658042371273,
0.000705575745087117,
0.0031338557600975037,
-0.0005246001528576016,
0.009847515262663364,
-0.0008048450108617544,
0.03567586466670036,
0.027538834139704704,
-0.013256271369755268,
0.006921361666172743,
0.012242197059094906,
-0.03264585882425308,
-0.03924344852566719,
-0.028565125539898872,
-0.002617655321955681,
0.025608427822589874,
-0.019976040348410606,
-0.03447852283716202,
0.004810743499547243,
0.004566388204693794,
-0.061186548322439194,
-0.010953223332762718,
0.06279928982257843,
0.0051009152084589005,
0.027318913489580154,
-0.006512066815048456,
0.013732763938605785,
0.04029417783021927,
0.01566316932439804,
-0.019511764869093895,
0.0156876053661108,
-0.015614299103617668,
-0.01287752017378807,
-0.02790536731481552,
-0.05165669322013855,
0.014123732224106789,
-0.023543626070022583,
0.01163741759955883,
0.01383050624281168,
0.050728145986795425,
0.015614299103617668,
-0.004062405787408352,
0.02175983227789402,
-0.038485947996377945,
0.03242594003677368,
0.03213271126151085,
0.028369642794132233,
0.021075638011097908,
-0.0111853601410985,
-0.03262142464518547,
0.010476730763912201,
-0.0006819037953391671,
0.006093608681112528,
0.022358503192663193,
-0.016335146501660347,
0.0035095519851893187,
-0.056299444288015366,
-0.013427319936454296,
0.01190009992569685,
0.03958554565906525,
-0.00929160788655281,
-0.008888421580195427,
-0.004190692212432623,
-0.03000682219862938,
-0.006890817545354366,
-0.006493740249425173,
0.03105754964053631,
0.039732158184051514,
-0.0037233626935631037,
0.004911540076136589,
0.007049648091197014,
0.018900876864790916,
-0.00001005221110972343,
-0.0034606808330863714,
0.01002467330545187,
-0.0025443488266319036,
-0.006799184251576662,
0.015492121689021587,
-0.017275914549827576,
0.024252256378531456,
-0.018045634031295776,
-0.017117083072662354,
0.038828045129776,
0.044277168810367584,
0.03130190446972847,
-0.014844579622149467,
0.0023473373148590326,
0.012669818475842476,
-0.014795709401369095,
0.027563270181417465,
-0.02156434953212738,
0.009102231822907925,
0.008992272429168224,
0.008289750665426254,
-0.018351078033447266,
0.0011232704855501652,
0.02270060032606125,
0.022566204890608788,
0.010513383895158768,
-0.01277977880090475,
0.006652571260929108,
0.015540992841124535,
-0.01651841402053833,
-0.018302205950021744,
0.026243751868605614,
-0.007471160963177681,
-0.02678133361041546,
0.017825713381171227,
-0.026708025485277176,
0.013024133630096912,
-0.012853085063397884,
0.011081509292125702,
-0.015589863061904907,
-0.01190009992569685,
0.04056296870112419,
-0.019988257437944412,
-0.01855877973139286,
0.03169287368655205,
-0.014832362532615662,
-0.016897164285182953,
-0.04501023143529892,
0.04185805097222328,
-0.041100550442934036,
-0.04012312740087509,
-0.018852006644010544,
-0.0005849253502674401,
-0.009059470146894455,
-0.015516556799411774,
0.017434746026992798,
-0.002119781682267785,
0.02062358148396015,
0.006622026674449444,
0.01207725703716278,
-0.01938958652317524,
0.02445995807647705,
0.015504338778555393,
0.018900876864790916,
-0.02741665579378605,
-0.011777921579778194,
0.017092648893594742,
-0.014013771899044514,
-0.00966424960643053,
-0.026439236477017403,
-0.0030483314767479897,
-0.005091751925647259,
0.013158529065549374,
0.0229205209761858,
0.015516556799411774,
0.020452532917261124,
-0.01836329512298107,
-0.010214048437774181,
0.005036772228777409,
0.008802897296845913,
-0.02639036439359188,
0.021527696400880814,
0.021588783711194992,
0.010220156982541084,
0.019536200910806656,
-0.0012103220215067267,
-0.03403868153691292,
-0.006921361666172743,
0.0005307089886628091,
-0.013842723332345486,
0.05214540660381317,
-0.022431809455156326,
-0.01974390260875225,
0.06353235989809036,
0.007587229833006859,
-0.011454151012003422,
0.006072227377444506,
0.011179251596331596,
0.00777660496532917,
0.022627294063568115,
-0.0038791391998529434,
0.025681734085083008,
0.010898242704570293,
-0.014404740184545517,
0.0005146731855347753,
0.03565142676234245,
-0.03814385086297989,
-0.00852188840508461,
-0.0015554737765341997,
0.008778461255133152,
0.003155236830934882,
0.020635798573493958,
-0.032499246299266815,
0.00028711737832054496,
-0.005733184516429901,
0.007226805668324232,
0.024032335728406906,
0.006353235803544521,
-0.002610019175335765,
0.062066227197647095,
0.03003125824034214,
-0.019780555739998817,
-0.009542071260511875,
-0.002625291468575597,
-0.004422829486429691,
-0.017275914549827576,
-0.014074861072003841,
-0.03579803928732872,
0.027074558660387993,
-0.022382939234375954,
0.010207939893007278,
-0.01814337633550167,
0.016396235674619675,
0.03489392623305321,
-0.009890277869999409,
-0.008937292732298374,
-0.007691080681979656,
0.004364795051515102,
-0.01662837341427803,
0.009328261017799377,
-0.005641551222652197,
-0.03042222559452057,
0.03176617994904518,
0.016066355630755424,
-0.0032193800434470177,
0.018216682597994804,
0.021503260359168053,
0.019120795652270317,
0.012926391325891018,
0.011863445863127708,
-0.009377132169902325,
-0.001829609740525484,
-0.04369071498513222,
0.042542245239019394,
-0.016176316887140274,
-0.02504641003906727,
-0.006890817545354366,
-0.005012336652725935,
-0.009236627258360386,
-0.0010980713414028287,
0.0015012574149295688,
0.00011005530541297048,
0.004920703358948231,
-0.020843500271439552,
-0.008943401277065277,
0.019401805475354195,
0.04801580309867859,
0.008582977578043938,
-0.026952382177114487,
0.023397013545036316,
0.009542071260511875,
0.016335146501660347,
0.016860511153936386,
-0.01690938137471676,
-0.0293959341943264,
-0.013744981959462166,
-0.0269768163561821,
-0.00770940724760294,
-0.027612140402197838,
0.020415879786014557,
0.0013500626664608717,
-0.005693476647138596,
0.02592608891427517,
0.006395997945219278,
0.02788093127310276,
0.004325087647885084,
0.00597753981128335,
-0.005204766523092985,
0.0033659932669252157,
0.030617710202932358,
0.022957174107432365,
0.03496723249554634,
-0.02614600956439972,
-0.02169874496757984,
-0.03166843578219414,
0.011466369032859802,
-0.004028806928545237,
-0.012657600454986095,
-0.00810648500919342,
0.015895307064056396,
-0.04571886360645294,
-0.004441156052052975,
-0.0051375688053667545,
0.05497992783784866,
-0.0030483314767479897,
0.017141519114375114,
0.012999698519706726,
0.007373419124633074,
0.002701652469113469,
0.012181107886135578,
0.02051362209022045,
0.023836852982640266,
0.015736477449536324,
-0.007257350254803896,
0.012101693078875542,
-0.03144851699471474,
0.0403674840927124,
0.0013874794822186232,
0.03985433652997017,
-0.024606570601463318,
-0.023849070072174072,
0.034454088658094406,
0.018412167206406593,
-0.017715753987431526,
0.009004490450024605,
0.019646160304546356,
0.009523744694888592,
-0.016567284241318703,
0.027978673577308655,
-0.024899797514081,
-0.006505957804620266,
0.007886565290391445,
0.01717817224562168,
0.013781635090708733,
0.01045229472219944,
0.005107024218887091,
0.0008040814427658916,
-0.004309815354645252,
-0.005653769243508577,
0.0023733002599328756,
0.014612442813813686,
-0.004493081942200661,
-0.003818050492554903,
-0.0100918710231781,
0.0025519849732518196,
-0.014465829357504845,
-0.03301239013671875,
-0.07726512104272842,
-0.013573932461440563,
0.0018861169228330255,
-0.013231835328042507,
0.0016845238860696554,
-0.013549497351050377,
-0.0015669278800487518,
0.035700298845767975,
-0.043861761689186096,
-0.007226805668324232,
0.03254811465740204,
0.002946007763966918,
-0.0030758213251829147,
0.009609268978238106,
0.026072703301906586,
0.014172603376209736,
-0.008063722401857376,
-0.020281484350562096,
-0.008564651012420654,
-0.010214048437774181,
0.017446963116526604,
-0.00016093082376755774,
0.03169287368655205,
0.026854639872908592,
-0.0177646242082119,
0.012181107886135578,
-0.012291068211197853,
-0.024704312905669212,
0.06377671658992767,
-0.008363057859241962,
0.0017792114522308111,
-0.010348443873226643,
0.0024908960331231356,
-0.01748361624777317,
0.02103898487985134,
0.03044666163623333,
-0.0020831283181905746,
0.008295860141515732,
0.021747615188360214,
0.032939083874225616,
-0.044277168810367584,
-0.021601002663373947,
0.039316754788160324,
0.01836329512298107,
-0.012620947323739529,
0.021820921450853348,
0.031204162165522575,
-0.008552432991564274,
-0.05366040766239166,
0.014025989919900894,
-0.011948970146477222,
-0.007049648091197014,
-0.04073401540517807,
0.02388572320342064,
-0.006811401806771755,
0.009523744694888592,
0.004459483083337545,
0.002524494891986251,
0.017727971076965332,
-0.008943401277065277,
0.002616128185763955,
-0.028467383235692978,
0.0017975381342694163,
-0.031619567424058914,
-0.013329577632248402,
-0.031863920390605927,
0.01436808705329895,
-0.03394094109535217,
0.010531710460782051,
0.0037477982696145773,
-0.001887644175440073,
0.01618853397667408,
0.01676276884973049,
0.0028788100462406874,
-0.004422829486429691,
-0.04232232645153999,
0.008527997881174088,
-0.0012423936277627945,
-0.04088062793016434,
-0.008033177815377712,
-0.001976222964003682,
-0.004187637474387884,
-0.006212731823325157,
-0.04735604301095009,
0.0010537819471210241,
0.004624422639608383,
-0.0183144249022007,
0.0018326642457395792,
0.04195579141378403,
-0.009273281320929527,
0.004554170649498701,
-0.02434999868273735,
0.02184535749256611,
-0.02189422771334648,
0.011912317015230656,
0.006811401806771755,
-0.02066023461520672,
-0.004355631768703461,
-0.011240340769290924,
-0.022578423842787743,
-0.025241894647479057,
-0.019511764869093895,
0.011240340769290924,
-0.015650952234864235,
-0.0010133106261491776,
-0.0027627411764115095,
-0.0055224280804395676,
-0.0014004608383402228,
0.02912714332342148,
-0.04354410246014595,
0.012187217362225056,
0.029957950115203857,
0.009022817015647888,
0.01954841800034046,
0.02305491641163826,
-0.016811639070510864,
-0.0043006520718336105,
-0.0032438156194984913,
0.024362215772271156,
-0.015675388276576996,
0.010659996420145035,
0.018021197989583015,
-0.009151102975010872,
-0.002515331609174609,
-0.011631309054791927,
-0.021063420921564102,
-0.04828459396958351,
0.011710723862051964,
-0.0287361741065979,
0.006286038085818291,
-0.00011186887422809377,
-0.053513795137405396,
0.028198592364788055,
-0.010928787291049957,
0.001368389232084155,
-0.005757620092481375,
0.023018263280391693,
-0.021906446665525436,
0.03347666561603546,
-0.00503371749073267,
-0.01925519108772278,
-0.01468574907630682,
0.010702759027481079,
-0.03501610457897186,
0.03626231476664543,
0.008558541536331177,
-0.022321850061416626,
0.007061866112053394,
0.015223330818116665,
-0.017104865983128548,
0.03127747029066086,
0.004548061639070511,
-0.021906446665525436,
0.004819906782358885,
0.00962759554386139,
-0.020122652873396873,
0.0239101592451334,
0.0061027719639241695,
0.006050846539437771,
0.029200449585914612,
0.05116798356175423,
-0.024692095816135406,
-0.02219967171549797,
-0.02959141880273819,
0.0016906327800825238,
-0.019976040348410606,
0.011686288751661777,
0.09524966776371002,
-0.021393300965428352,
-0.034185297787189484,
0.010623343288898468,
-0.0017181227449327707,
-0.032254889607429504,
0.010800501331686974,
0.003744743764400482,
0.03919458016753197,
-0.02057470940053463,
0.017776843160390854,
0.011857337318360806,
0.03391650691628456,
0.03518715128302574,
0.03496723249554634,
-0.02274947240948677,
-0.015174459666013718,
0.04735604301095009,
0.016005266457796097,
0.002978079253807664,
0.013573932461440563,
-0.01800898090004921,
0.0002840629604179412,
0.009248845279216766,
-0.02553512156009674,
-0.003573695197701454,
-0.024178950116038322,
-0.029542546719312668,
-0.00034992431756109,
-0.037655141204595566,
0.021991970017552376,
0.00023671911912970245,
0.011655744165182114,
-0.030617710202932358,
-0.005638496950268745,
-0.021332211792469025,
-0.007581120822578669,
-0.024692095816135406,
0.011539675295352936,
0.005006227642297745,
0.00926717184484005,
0.016090791672468185,
0.01468574907630682,
0.016982687637209892,
0.018656522035598755,
-0.013732763938605785,
-0.020342573523521423,
-0.016176316887140274,
0.004202909767627716,
-0.028345206752419472,
0.016176316887140274,
0.008699046447873116,
0.022932738065719604,
-0.0019746955949813128,
-0.029493676498532295,
-0.03235263377428055,
0.02656141296029091,
0.013964901678264141,
-0.013867159374058247,
-0.041491515934467316,
-0.021930880844593048,
0.020696887746453285,
0.022566204890608788,
0.016982687637209892,
-0.0015944178448989987
] | 2025-01-03 | 1 | 39746895 | [
"CAR design",
"CAR",
"DNR co",
"CAR-T cell survival",
"DNR",
"CAR-T cell exhaustion",
"recurrent ovarian cancer",
"solid tumours",
"ovarian cancer",
"remarkable efficacy",
"tumour rechallenge",
"Chimeric antigen receptor",
"haematological malignancies",
"antitumor activity",
"-",
"expression",
"TREM1/DAP12-BB CAR-T cells",
"CAR) T-cell therapy",
"conferred resilience",
"vivo evaluations",
"TGF-β signalling",
"a novel SS1-TREM1/DAP12-BB CAR-T cell",
"TME",
"patients",
"the immunosuppressive tumour microenvironment",
"a novel therapeutic strategy",
"TREM1/DAP12-BB",
"the dominant-negative TGF",
"the antitumor efficacy",
"(DNR"
] | [
"DAP12",
"chimeric antigen receptor (CAR) T‐cell",
"dominant‐negative TGF‐β receptor 2 (DNR)",
"ovarian cancer",
"tumour microenvironment (TME)"
] | 0 | 10.1111/imm.13888 | [
"Zhu",
"Hu",
"Lin",
"Wang",
"Wang"
] | [
"Nanjing CART Medical Technology Co. Ltd., Nanjing, P.R. China.",
"Nanjing CART Medical Technology Co. Ltd., Nanjing, P.R. China.",
"Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.",
"Nanjing CART Medical Technology Co. Ltd., Nanjing, P.R. China.",
"Nanjing CART Medical Technology Co. Ltd., Nanjing, P.R. China.\nDepartment of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, P.R. China.\nClinical Pathological Diagnosis & Research Center, Youjiang Medical University for Nationalities, Baise, P.R. China.\nThe Key Laboratory of Molecular Pathology (Hepatobiliary Diseases) of Guangxi, Baise, P.R. China."
] | [
"39746895"
] | [] | 9.972128 | 5.861783 |
39743260 | 88 | [Fever Characteristics and Biomarker Changes of CRS in Patients with Relapsed/Refractory Multiple Myeloma after CAR-T Cell Therapy]. | To investigate the correlation of the clinical characteristics, fever characteristics, serum biomarkers with cytokine release syndrome (CRS) in patients with relapsed/refractory multiple myeloma (R/R MM) treated with chimeric antigen receptor T cell (CAR-T) immunotherapy.
104 R/R MM patients who received CAR-T cell therapy at the Affiliated Hospital of Xuzhou Medical University from June 2017 to November 2021 were included, and the correlations of their clinical characteristics, fever characteristics, serum biomarkers with the severity of CRS were analyzed.
Among 104 R/R MM patients receiving CAR-T treatment, no CRS was observed in 8 cases (7.7%), and 96 cases (92.3%) developed CRS. Patients with high-risk cytogenetics had a higher risk of developing CRS (
High-risk cytogenetics is a risk factor for severe CRS. Long duration of fever is a clinical characteristic of severe CRS. CRP can better reflect the severity of CRS.
复发难治性多发性骨髓瘤患者CAR-T细胞治疗后CRS的发热特征和生物标志物变化.
探讨嵌合抗原受体T细胞（CAR-T）免疫疗法治疗复发难治性多发性骨髓瘤（R/R MM）患者后，患者的临床特征、发热特征和血清生物标志物与细胞因子释放综合征（CRS）的关系，以便更好地预测、治疗CRS。.
纳入2017年6月至2021年11月期间在徐州医科大学附属医院接受CAR-T治疗的104例R/R MM患者，分析患者的临床特征、发热特征和血清生物标志物与CRS严重程度之间的关系。.
104例接受CAR-T治疗的R/R MM患者中，有8例（7.7%）未观察到CRS发生，96例（92.3％）发生CRS。具有高危细胞遗传学特征的患者发生CRS的风险较高（
高危细胞遗传学特征是发生严重CRS的危险因素。较长的发热持续时间是严重CRS的临床特征。CRP能更好地反映CRS的严重程度。. | [
-0.0006119546014815569,
0.02669128030538559,
0.03867329657077789,
0.044552531093358994,
-0.024276994168758392,
0.008919447660446167,
0.013647425919771194,
-0.020051991567015648,
0.012876194901764393,
-0.007734659127891064,
-0.02926204726099968,
-0.03257051482796669,
-0.048553988337516785,
0.03243638947606087,
0.009422424249351025,
-0.01232851017266512,
-0.010098648257553577,
0.011406386271119118,
-0.02868083119392395,
0.03308466821908951,
0.022633936256170273,
0.03789088875055313,
0.016307612881064415,
-0.03069273568689823,
-0.004688857588917017,
0.021002057939767838,
0.019481951370835304,
-0.0019462391501292586,
0.0015508438227698207,
-0.03507421910762787,
0.0081593943759799,
-0.023159267380833626,
0.013870971277356148,
-0.022164491936564445,
-0.03187752515077591,
0.03898625820875168,
0.017715945839881897,
-0.006555458996444941,
-0.010327781550586224,
-0.030223291367292404,
0.01888955757021904,
0.028837312012910843,
-0.015066936612129211,
0.06531986594200134,
-0.06536457687616348,
-0.03147514536976814,
0.021359730511903763,
-0.05463441088795662,
0.036124881356954575,
0.007304334547370672,
-0.000572834222111851,
0.027004243806004524,
0.004848133306950331,
0.018688367679715157,
-0.01531283650547266,
0.04182527959346771,
-0.008064388297498226,
0.02930675633251667,
0.05360610410571098,
-0.03366588428616524,
0.039321575313806534,
-0.07618415355682373,
-0.0050996216014027596,
-0.05669102817773819,
-0.02611006237566471,
-0.04707859084010124,
0.00045267873792909086,
-0.01849835366010666,
-0.011361677199602127,
0.023114558309316635,
0.026311254128813744,
-0.02528294548392296,
0.05074472725391388,
0.028501994907855988,
0.05146007239818573,
0.014340415596961975,
0.012585586868226528,
-0.03630371764302254,
-0.01694471575319767,
-0.025797098875045776,
0.005362287163734436,
0.005203011445701122,
0.011702584102749825,
-0.01956019178032875,
-0.030111519619822502,
-0.023740485310554504,
0.03250345215201378,
-0.03722025081515312,
0.031050408259034157,
0.0036745218094438314,
-0.03366588428616524,
0.025864163413643837,
-0.013245044276118279,
0.014698087237775326,
-0.026557153090834618,
-0.021080298349261284,
0.01817421242594719,
-0.028814958408474922,
-0.013647425919771194,
0.02217566967010498,
0.052398961037397385,
0.020007282495498657,
-0.02787606790661812,
0.02792077697813511,
-0.009925400838255882,
0.006371034309267998,
-0.06581166386604309,
-0.030737444758415222,
0.03646019846200943,
-0.039321575313806534,
0.07479817420244217,
0.008422059938311577,
-0.06858362257480621,
0.06290557980537415,
0.007533468306064606,
-0.0068795992992818356,
-0.07399341464042664,
-0.0494481660425663,
-0.02009670063853264,
0.02398638427257538,
-0.03310702368617058,
0.029686784371733665,
-0.012283801101148129,
-0.04421721398830414,
-0.017302388325333595,
-0.016117598861455917,
0.08306934684515,
-0.025148818269371986,
-0.060178328305482864,
-0.05651219189167023,
-0.0007062626536935568,
-0.035521309822797775,
0.02347223088145256,
-0.03603546321392059,
-0.0133232856169343,
-0.015044582076370716,
0.00716461893171072,
-0.008869149722158909,
-0.05226483568549156,
-0.003333615604788065,
0.017402982339262962,
0.00994216650724411,
-0.0032050772570073605,
0.02241039276123047,
-0.005462882574647665,
-0.04976113140583038,
-0.024500537663698196,
0.01627407968044281,
0.0027482069563120604,
0.0023877406492829323,
-0.05347197875380516,
0.047883350402116776,
0.04039459303021431,
-0.008673548698425293,
0.044709011912345886,
-0.0388968400657177,
0.0547238290309906,
0.06545399129390717,
-0.022164491936564445,
-0.04043930023908615,
0.0035627493634819984,
-0.0014921632828190923,
-0.03368823975324631,
-0.0312068909406662,
0.04544670879840851,
-0.025595908984541893,
-0.009919811971485615,
0.04410544037818909,
-0.02608770877122879,
-0.026199480518698692,
-0.011512570083141327,
-0.021046767011284828,
-0.05915002152323723,
-0.01748122274875641,
-0.03838268667459488,
0.007343455217778683,
0.038740359246730804,
-0.007186973467469215,
-0.0002958479162771255,
0.026221835985779762,
0.011937306262552738,
0.00914299301803112,
0.007214916869997978,
0.02803255058825016,
-0.023807547986507416,
-0.013613893650472164,
-0.010042761452496052,
0.018643658608198166,
-0.026557153090834618,
-0.006482806522399187,
0.016676461324095726,
0.004401043523102999,
0.05002938210964203,
-0.013457412831485271,
0.012093788012862206,
-0.03728731721639633,
0.02928440272808075,
0.04245120659470558,
-0.05812171474099159,
-0.011160487309098244,
0.021717403084039688,
0.020633209496736526,
-0.053829651325941086,
-0.01717943698167801,
-0.02792077697813511,
-0.016654107719659805,
0.01914663426578045,
0.0447760745882988,
-0.04225001484155655,
0.0028236533980816603,
0.059552405029535294,
0.003615841269493103,
0.01854306273162365,
0.032816413789987564,
-0.006041305139660835,
-0.003003886668011546,
-0.027719587087631226,
0.026534797623753548,
0.021326199173927307,
0.008969745598733425,
0.01715708337724209,
-0.041154645383358,
0.0018861613934859633,
0.049805838614702225,
-0.029731493443250656,
0.00731551181524992,
0.055126212537288666,
0.007091966923326254,
0.0055914209224283695,
-0.03460477665066719,
-0.02249981090426445,
0.06290557980537415,
-0.016542334109544754,
-0.04039459303021431,
-0.021728578954935074,
-0.045916154980659485,
0.012104964815080166,
0.014005097560584545,
0.04504432901740074,
-0.006376622710376978,
0.03187752515077591,
0.0320340059697628,
0.011339322663843632,
-0.003926009871065617,
-0.000051258182793390006,
-0.016631752252578735,
-0.00605807127431035,
-0.06393388658761978,
0.01703413389623165,
0.020845577120780945,
-0.003934393171221018,
0.02662421576678753,
-0.028345514088869095,
-0.04882223904132843,
0.0024799529928714037,
-0.029664428904652596,
-0.0016891623381525278,
-0.02539471909403801,
-0.005281251855194569,
-0.03704141452908516,
0.00365775590762496,
-0.04289829730987549,
-0.032190486788749695,
-0.06192198023200035,
-0.000016995099940686487,
0.0032022830564528704,
-0.01821892149746418,
0.015759926289319992,
0.008517066948115826,
0.008980922400951385,
0.010791637934744358,
0.00034038227749988437,
0.031519852578639984,
-0.0017045310232788324,
-0.020957348868250847,
0.05002938210964203,
0.009115049615502357,
0.0326375775039196,
-0.012283801101148129,
0.003540394827723503,
0.01670999266207218,
0.024522893130779266,
0.019426066428422928,
-0.058926478028297424,
-0.01526812743395567,
-0.030491545796394348,
0.03458242118358612,
0.016139952465891838,
-0.016419384628534317,
-0.014273351989686489,
0.004029399715363979,
-0.005504797212779522,
-0.003207871690392494,
-0.0034146506804972887,
-0.034895382821559906,
0.0156034454703331,
-0.027160724624991417,
-0.006069248542189598,
-0.047838643193244934,
0.027831358835101128,
-0.01928076148033142,
0.03918744996190071,
-0.03469419479370117,
-0.024276994168758392,
0.04043930023908615,
0.029776202514767647,
-0.016844119876623154,
-0.05660161003470421,
-0.006723117548972368,
0.03198929876089096,
-0.02481350116431713,
-0.037488505244255066,
0.01298796758055687,
0.011467861011624336,
0.025640618056058884,
0.007209328003227711,
0.04276416823267937,
-0.030133873224258423,
0.004361922852694988,
-0.02599829062819481,
-0.009662735275924206,
-0.02143797092139721,
0.002903291489928961,
0.005705987568944693,
-0.03643784299492836,
-0.038069725036621094,
0.014094515703618526,
-0.007276391610503197,
0.010908998548984528,
-0.05061060190200806,
0.049805838614702225,
-0.04251826927065849,
0.06782357394695282,
-0.012004369869828224,
0.0028515965677797794,
-0.027898423373699188,
-0.025640618056058884,
-0.012093788012862206,
-0.00635985704138875,
-0.0027021009009331465,
-0.000626624736469239,
0.0013650220353156328,
-0.024589955806732178,
0.043881893157958984,
-0.006398977246135473,
-0.05195187032222748,
-0.017224146053195,
-0.007304334547370672,
0.0024212724529206753,
0.007980559021234512,
0.04155702516436577,
0.02476879209280014,
0.03330821543931961,
0.05011880025267601,
-0.0026545976288616657,
-0.00666723120957613,
-0.014105693437159061,
-0.002975943498313427,
0.01463102363049984,
-0.00750552536919713,
0.006041305139660835,
0.01333446241915226,
-0.013602716848254204,
0.013356816954910755,
0.09281590580940247,
0.08655664324760437,
-0.024433474987745285,
0.008595307357609272,
-0.014530428685247898,
-0.05078943818807602,
-0.018062440678477287,
0.03136337175965309,
0.0162070170044899,
-0.018621303141117096,
-0.025014691054821014,
0.03216813504695892,
0.0005826143315061927,
0.024254638701677322,
-0.018923088908195496,
0.02044319547712803,
0.027607815340161324,
-0.025238236412405968,
0.029709137976169586,
-0.03259287029504776,
0.0072372714057564735,
0.045916154980659485,
-0.010864289477467537,
-0.0020566144958138466,
-0.06205610930919647,
0.057585205882787704,
-0.012317332439124584,
0.003621429903432727,
-0.0013936636969447136,
-0.03858387842774391,
-0.005155507940798998,
0.04549141973257065,
-0.013490944169461727,
0.10998416692018509,
0.01845364458858967,
-0.006784592289477587,
-0.015815813094377518,
-0.03601310774683952,
-0.031430434435606,
-0.018945444375276566,
0.027250142768025398,
0.015111645683646202,
-0.017671236768364906,
-0.009355360642075539,
0.01038366835564375,
-0.020845577120780945,
-0.038829777389764786,
0.004599439445883036,
0.017727123573422432,
0.0121161425486207,
-0.0009214247693307698,
-0.0273619145154953,
-0.0993434265255928,
0.053740233182907104,
-0.014206288382411003,
0.01603935845196247,
0.018084794282913208,
-0.0034509769175201654,
0.023114558309316635,
0.005339932627975941,
-0.02127031236886978,
-0.03310702368617058,
0.010562503710389137,
-0.01912427879869938,
0.0382932685315609,
-0.03856152296066284,
0.005750696640461683,
0.028300805017352104,
0.007231682538986206,
-0.024455828592181206,
-0.0023388401605188847,
0.0008061593398451805,
-0.03402355685830116,
0.009087106212973595,
-0.034135330468416214,
0.020644385367631912,
0.03630371764302254,
0.0015564324567094445,
-0.05284605175256729,
-0.037488505244255066,
0.06335266679525375,
-0.013490944169461727,
0.025841807946562767,
0.047123298048973083,
-0.007483170833438635,
0.011579633690416813,
-0.012697359547019005,
-0.04504432901740074,
0.03176575154066086,
-0.006443686317652464,
-0.002431052504107356,
-0.02868083119392395,
0.014351592399179935,
-0.07855373620986938,
-0.010808403603732586,
0.02733956091105938,
0.02729485183954239,
-0.030938636511564255,
0.007835254073143005,
-0.03650490939617157,
0.009947755374014378,
-0.017559465020895004,
0.009752153418958187,
-0.0285690575838089,
0.03167633339762688,
-0.02011905610561371,
0.029463239014148712,
0.0014390712603926659,
-0.01826363056898117,
0.008852384053170681,
0.01307738572359085,
0.01815185882151127,
0.024455828592181206,
0.01232851017266512,
0.041422899812459946,
0.003789088688790798,
-0.006650465540587902,
-0.015804635360836983,
-0.023047495633363724,
-0.007689950056374073,
0.02794313244521618,
0.04368070513010025,
0.02416522055864334,
0.020733803510665894,
-0.04895636811852455,
0.043412450700998306,
-0.004979466088116169,
0.0204655509442091,
-0.0037471740506589413,
-0.008606485091149807,
0.0267583429813385,
-0.024522893130779266,
-0.0022633937187492847,
-0.012630295939743519,
-0.009718621149659157,
-0.011646697297692299,
0.0008103508152998984,
0.016810588538646698,
0.02602064423263073,
0.018699543550610542,
0.01463102363049984,
0.07046139985322952,
0.00544052803888917,
0.042004115879535675,
-0.030133873224258423,
0.042741816490888596,
0.0071031441912055016,
0.010646332986652851,
0.034135330468416214,
0.016139952465891838,
-0.016151130199432373,
-0.013166803866624832,
-0.008969745598733425,
-0.039433348923921585,
0.001789757632650435,
-0.01333446241915226,
0.013189158402383327,
-0.018487175926566124,
0.008729434572160244,
0.011814355850219727,
0.017369451001286507,
-0.03328585997223854,
-0.012451459653675556,
-0.0027258526533842087,
-0.031542208045721054,
-0.0686730444431305,
0.006052482407540083,
-0.00909828394651413,
0.03440358489751816,
0.021292665973305702,
0.009601260535418987,
-0.0030402126722037792,
-0.020242005586624146,
-0.012484991922974586,
-0.04155702516436577,
-0.020286714658141136,
0.008969745598733425,
-0.04770451411604881,
-0.007516702637076378,
-0.04569261148571968,
0.017928313463926315,
0.0261547714471817,
0.012194382958114147,
-0.01738062873482704,
0.010702219791710377,
-0.02988797426223755,
0.020007282495498657,
-0.06491748243570328,
0.02722778730094433,
-0.010512206703424454,
0.019828446209430695,
0.002510690363124013,
-0.009964521043002605,
-0.03956747427582741,
-0.019381357356905937,
-0.02143797092139721,
0.00251208757981658,
0.0013126286212354898,
-0.0012790969340130687,
-0.007913495413959026,
-0.06496219336986542,
-0.014798683114349842,
0.012294977903366089,
-0.026467734947800636,
-0.014396301470696926,
0.02528294548392296,
-0.0009137404267676175,
-0.003993073478341103,
0.008014090359210968,
-0.01336799468845129,
0.020588500425219536,
-0.028479639440774918,
-0.009835982695221901,
0.002686732215806842,
-0.005686427466571331,
-0.008014090359210968,
-0.027764296159148216,
-0.03261522576212883,
0.004982260521501303,
0.05678044632077217,
-0.014597492292523384,
0.018140681087970734,
-0.019850801676511765,
-0.022533342242240906,
-0.0218962375074625,
0.020711449906229973,
0.040662847459316254,
0.011590811423957348,
0.04672091826796532,
-0.01867718994617462,
-0.005957475863397121,
0.03639313578605652,
-0.01845364458858967,
-0.02353929542005062,
0.0002235450519947335,
0.032950542867183685,
0.0021977273281663656,
-0.007645240984857082,
-0.025260591879487038,
-0.03699670732021332,
-0.000501579197589308,
0.05812171474099159,
0.019180165603756905,
-0.008662370964884758,
-0.018464822322130203,
0.02409815788269043,
0.02180682122707367,
0.05539446696639061,
-0.040059275925159454,
0.023226331919431686,
0.04048401117324829,
0.04218295216560364,
-0.022980431094765663,
-0.016095243394374847,
-0.003154779551550746,
-0.009578905999660492,
-0.021695047616958618,
0.024545246735215187,
-0.009735386818647385,
-0.045290227979421616,
0.03661667928099632,
-0.019984928891062737,
0.0076508293859660625,
0.01960490085184574,
0.013859793543815613,
0.020342599600553513,
-0.0011289025424048305,
0.007723481860011816,
-0.046542081981897354,
-0.00437589455395937,
0.022958077490329742,
0.02546178176999092,
-0.0099868755787611,
-0.008220869116485119,
-0.011758469976484776,
-0.01306620892137289,
0.009204467758536339,
0.02048790454864502,
-0.0199737511575222,
-0.03903096541762352,
0.004401043523102999,
-0.02863612212240696,
0.009372126311063766,
0.0003424780152272433,
-0.015759926289319992,
0.0029647662304341793,
-0.0202755369246006,
-0.038114432245492935,
0.009159758687019348,
-0.005373464431613684,
-0.006851655896753073,
-0.045916154980659485,
0.005373464431613684,
0.009735386818647385,
0.058881767094135284,
0.07193680107593536,
0.00008439699013251811,
-0.0029144687578082085,
-0.034783609211444855,
0.020297890529036522,
-0.0004180991090834141,
0.051147110760211945,
0.01932547055184841,
-0.004839750472456217,
0.00715903053060174,
0.04806218668818474,
0.10533443093299866,
0.03715318813920021,
0.00091443897690624,
-0.0014740002807229757,
-0.004286476410925388,
0.0036633445415645838,
0.026914825662970543,
0.0089138587936759,
-0.010568092577159405,
0.04090874642133713,
-0.000411462620832026,
0.01895662024617195,
-0.02009670063853264,
-0.06804711371660233,
-0.01401627529412508,
-0.015480495058000088,
0.0076508293859660625,
-0.022656291723251343,
0.0023905348498374224,
0.009237999096512794,
-0.01393803395330906,
0.00043870718218386173,
-0.023002786561846733,
-0.0054992083460092545,
0.009835982695221901,
-0.00016303070879075676,
-0.03862858563661575,
-0.004275299143046141,
-0.0012874797685071826,
0.025864163413643837,
0.0650516152381897,
0.019549015909433365,
0.03004445508122444,
-0.005474059376865625,
0.0014376741601154208,
-0.028166677802801132,
-0.003473331220448017,
-0.053740233182907104,
0.027205433696508408,
0.014921632595360279,
0.019001329317688942,
-0.00014329588157124817,
-0.017704768106341362,
-0.029105566442012787,
-0.019426066428422928,
0.010875467211008072,
-0.013904502615332603,
0.03167633339762688,
0.004286476410925388,
0.017000602558255196,
0.018923088908195496,
0.03916509449481964,
-0.036773163825273514,
-0.01567050814628601,
0.0026615832466632128,
0.029820911586284637,
-0.011512570083141327,
0.03176575154066086,
-0.030759800225496292,
-0.00601895060390234,
-0.0003349682956468314,
-0.004071314353495836,
-0.00890268199145794,
-0.01333446241915226,
-0.007438461761921644,
0.026423025876283646,
0.010959296487271786,
-0.00685724476352334,
-0.022600404918193817,
-0.015514027327299118,
0.03317408636212349,
-0.024321701377630234,
-0.08347172290086746,
0.027585459873080254,
-0.007639652583748102,
0.021728578954935074,
0.05056589096784592,
0.01208261027932167,
-0.0092156445607543,
0.003112864913418889,
0.00044045361573807895,
0.006549870129674673,
-0.017045309767127037,
-0.03147514536976814,
0.03594604507088661,
-0.02863612212240696,
0.003898066934198141,
-0.001641659066081047,
-0.06469394266605377,
0.017257679253816605,
-0.020677918568253517,
0.02794313244521618,
0.02546178176999092,
-0.02353929542005062,
0.03514128178358078,
0.015536381863057613,
0.011892597191035748,
0.0261547714471817,
-0.03688493371009827,
0.0033224383369088173,
0.016430562362074852,
-0.05387435853481293,
0.017492400482296944,
-0.012149673886597157,
0.005029764026403427,
0.014262174256145954,
-0.04432898387312889,
-0.027004243806004524,
-0.03733202442526817,
-0.027741942554712296,
0.013602716848254204,
-0.023025140166282654,
-0.004146760795265436,
0.0027342354878783226,
-0.0160170029848814,
0.018040087074041367,
0.001112136640585959,
0.014843392185866833,
-0.009578905999660492,
0.012909727171063423,
-0.01793949119746685,
0.03514128178358078,
-0.004714006558060646,
-0.002359797479584813,
-0.01738062873482704,
0.04110993444919586,
0.011646697297692299,
-0.06500690430402756,
-0.007242859806865454,
-0.0330176055431366,
-0.024344056844711304,
0.0009423821466043591,
0.01268618181347847,
-0.024992337450385094,
0.013122094795107841,
0.0028781425207853317,
-0.017168261110782623,
0.03867329657077789,
0.0025609880685806274,
0.003367147408425808,
-0.0034537711180746555,
-0.01567050814628601,
-0.01173611544072628,
-0.00700813764706254,
-0.02062203176319599,
0.0023542088456451893,
0.01949312910437584,
-0.0018526297062635422,
-0.008410883136093616,
-0.02465702034533024,
0.021795643493533134,
0.013792729936540127,
0.014407479204237461,
-0.021370908245444298,
-0.023628711700439453,
-0.0009353963541798294,
0.008399705402553082,
0.029709137976169586,
0.019437242299318314,
0.023673420771956444,
0.004853722173720598,
-0.0014586314791813493,
-0.028501994907855988,
-0.018509531393647194,
-0.005482442677021027,
0.01573757268488407,
-0.00011491613258840516,
0.005513180047273636,
0.02405344881117344,
0.03400120511651039,
0.03308466821908951,
0.011982015334069729,
-0.002445023972541094,
-0.03317408636212349,
0.006192198023200035,
0.02398638427257538,
-0.01830833964049816,
-0.0054908255115151405,
0.0017268855590373278,
0.003216254524886608,
0.0024925274774432182,
-0.013312107883393764,
0.018788961693644524,
-0.013613893650472164,
0.021046767011284828,
0.012138497084379196,
0.0013238058891147375,
-0.02044319547712803,
0.004320008214563131,
0.02666892483830452,
-0.013502121903002262,
0.001535475137643516,
0.0008515669615007937,
-0.0648280680179596,
0.015145177952945232,
-0.05910531431436539,
0.0214826799929142,
0.003216254524886608,
-0.02284630574285984,
-0.035409536212682724,
0.03894154727458954,
0.0011889802990481257,
0.0013615291099995375,
-0.006264850031584501,
-0.016262903809547424,
-0.04935874789953232,
0.012932081706821918,
0.007969381287693977,
-0.03473890200257301,
-0.021862706169486046,
-0.009327417239546776,
-0.04412779584527016,
-0.021616807207465172,
-0.008952979929745197,
0.009930988773703575,
0.03462712839245796,
-0.010813992470502853,
-0.003831003326922655,
-0.007097555790096521,
-0.006622522138059139,
0.02349458634853363,
0.020800868049263954,
-0.01687765121459961,
-0.03500715643167496,
-0.0332411490380764,
0.0214826799929142,
0.007075201254338026,
0.011428740806877613,
-0.047212716192007065,
0.009461544454097748,
0.0061139571480453014,
-0.004719594959169626,
-0.032950542867183685,
0.0443960502743721,
0.005203011445701122,
-0.00414955522865057,
-0.04227237030863762,
0.022645113989710808,
-0.003537600627169013,
0.027540750801563263,
-0.01863248087465763,
0.01817421242594719,
-0.020756158977746964,
0.006086014211177826,
-0.004923579748719931,
-0.001960210734978318,
0.011132543906569481,
0.02611006237566471,
0.00225081923417747,
0.0127197140827775,
-0.01819656789302826,
-0.008997689001262188,
0.043792475014925,
0.004672091919928789,
0.02727249637246132,
0.025886517018079758,
0.009428013116121292,
0.011350500397384167,
0.03368823975324631,
0.008422059938311577,
0.018923088908195496,
-0.010406022891402245,
0.023785194382071495,
0.013736844062805176,
-0.004015428014099598,
0.012496168725192547,
0.006633699405938387,
-0.023092204704880714,
0.016978247091174126,
0.01696706935763359,
-0.027496041730046272,
-0.006549870129674673,
-0.017224146053195,
-0.0338447205722332,
0.020353777334094048,
-0.022097429260611534,
0.005222571548074484,
-0.01629643514752388,
-0.005063295364379883,
0.021024413406848907,
0.04886694997549057,
0.005353904329240322,
0.020107878372073174,
-0.036929644644260406,
-0.024902919307351112,
-0.03404591232538223,
-0.024388765916228294,
-0.013043854385614395,
0.05928415060043335,
-0.016564689576625824,
-0.03435887396335602,
0.02617712691426277,
-0.029083212837576866,
-0.0022452306002378464,
-0.02333810366690159,
-0.006611344870179892,
0.015525204129517078,
0.011859064921736717,
-0.07216034829616547,
0.01063515618443489,
0.005105210468173027,
-0.030446836724877357,
0.0011386825935915112,
-0.011026360094547272,
0.009740975685417652,
0.028323158621788025,
0.009819217026233673,
-0.024478184059262276,
0.009439189918339252,
0.005968653131276369,
0.01009305939078331,
0.02048790454864502,
0.010478674434125423,
-0.009014454670250416,
-0.016050534322857857,
0.003864535130560398,
0.02353929542005062,
-0.03688493371009827,
-0.022030364722013474,
-0.005985418800264597,
0.05669102817773819,
0.018408935517072678,
-0.018040087074041367,
0.010109825059771538,
0.010143357329070568,
-0.029865620657801628,
-0.014239819720387459,
-0.008081153966486454,
0.031609270721673965,
0.03697435185313225,
-0.021605629473924637,
0.01466455589979887,
0.0024939244613051414,
-0.0009004674502648413,
-0.03710848093032837,
0.008019679225981236,
0.010020406916737556,
-0.0021306637208908796,
0.01914663426578045,
-0.021627984941005707,
0.0054237619042396545,
0.007885552011430264,
-0.009366538375616074,
0.021024413406848907,
0.03250345215201378,
-0.0211808942258358,
-0.0006542186019942164,
-0.02995503693819046,
-0.030469192191958427,
0.02247745543718338,
-0.004406631924211979,
0.012865018099546432,
0.025148818269371986,
0.004320008214563131,
-0.007030492182821035,
0.0014446598943322897,
0.021750934422016144,
-0.019481951370835304,
0.018420113250613213,
0.024969983845949173,
-0.03174339979887009,
-0.0031240421812981367,
-0.0028068877290934324,
0.00735463248565793,
-0.002035657176747918,
-0.03198929876089096,
-0.02742897905409336,
0.025171173736453056,
0.0031016876455396414,
-0.02608770877122879,
-0.03847210481762886,
-0.038203850388526917,
-0.005630541127175093,
0.046586789190769196,
-0.006259261630475521,
-0.0266465712338686,
-0.0022773651871830225,
-0.0060804253444075584,
-0.027540750801563263,
0.022913368418812752,
0.027585459873080254,
0.015715217217803,
0.001219717669300735,
-0.022276265546679497,
0.007142264395952225,
0.03207871690392494,
0.0320340059697628,
-0.02154974266886711,
-0.00564171839505434,
-0.012753245420753956,
-0.010746928863227367,
0.030469192191958427,
-0.012160850688815117,
-0.026490088552236557,
0.003372736042365432,
-0.005057706963270903,
-0.021974479779601097,
0.002153018256649375,
-0.014150402508676052,
-0.04372541233897209,
-0.005169479642063379,
-0.019392533227801323,
-0.013893324881792068,
0.02530530095100403,
0.007047257851809263,
0.017078842967748642,
0.007852019742131233,
-0.021281490102410316,
0.0060804253444075584,
0.0030569785740226507,
-0.027741942554712296,
0.02930675633251667,
0.011384031735360622,
-0.016173485666513443,
-0.03663903474807739,
0.023136913776397705,
-0.00017805014795158058,
-0.0007244257139973342,
0.01603935845196247,
-0.013010322116315365,
-0.015502849593758583,
-0.009835982695221901,
-0.012954436242580414,
0.003260963596403599,
-0.017257679253816605,
0.003828209126368165,
0.003965130541473627,
0.006974605843424797,
0.0027719587087631226,
0.01634114421904087,
-0.027853714302182198,
-0.02921733818948269,
0.010540149174630642,
-0.016329966485500336,
-0.019001329317688942,
-0.006566636264324188,
-0.019806092604994774,
-0.02660186216235161,
-0.01242910511791706,
-0.023092204704880714,
-0.011534924618899822,
0.024947628378868103,
-0.0020482316613197327,
-0.023092204704880714,
0.015111645683646202,
0.013770375400781631,
0.0202755369246006,
-0.019370179623365402,
0.02729485183954239,
-0.017648883163928986,
-0.00750552536919713,
-0.02467937394976616,
0.028367867693305016,
0.005337138194590807,
-0.0025959170889109373,
-0.006315147969871759,
-0.000384567363653332,
-0.02805490419268608,
0.00926035363227129,
-0.021404439583420753,
0.01603935845196247,
0.007958204485476017,
0.011512570083141327,
0.003791883122175932,
0.019426066428422928,
-0.008813263848423958,
-0.0023584002628922462,
-0.02219802513718605,
-0.008701491169631481,
0.006533104460686445,
0.004272504709661007,
0.043233614414930344,
-0.018967797979712486,
-0.004904019646346569,
-0.00635985704138875,
-0.009047986008226871,
-0.045960862189531326,
0.06643759459257126,
0.031005699187517166,
-0.01397156622260809,
0.032861124724149704,
-0.000178836053237319,
0.006007773336023092,
-0.042697105556726456,
0.02048790454864502,
0.014955163933336735,
-0.028256095945835114,
-0.022075073793530464,
0.03719789907336235,
0.019783737137913704,
-0.032235197722911835,
-0.004071314353495836,
0.012943258509039879,
-0.0385168120265007,
0.006611344870179892,
-0.022935722023248672,
0.034850675612688065,
0.006097191479057074,
-0.01947077363729477,
0.0002261647314298898,
0.010646332986652851,
0.0055327401496469975,
0.026355963200330734,
0.03004445508122444,
0.020722627639770508,
-0.0032386090606451035,
0.011870242655277252,
-0.005700399167835712,
0.00430603651329875,
0.010517794638872147,
-0.03431416675448418,
-0.01562579907476902,
-0.018833670765161514,
-0.02930675633251667,
-0.006728706415742636,
0.025774745270609856,
-0.01701177842915058,
0.01306620892137289,
-0.03138572722673416,
0.030290355905890465,
0.009075929410755634,
-0.001756225829012692,
-0.008109097369015217,
-0.019683143123984337,
-0.00751111377030611,
-0.005912766791880131,
0.025260591879487038,
0.014407479204237461,
-0.03641549125313759,
-0.010277483612298965,
-0.018666012212634087,
0.017067665234208107,
0.02474643848836422,
-0.01207143347710371,
0.010271895676851273,
0.02745133265852928,
0.012820309028029442,
-0.019135456532239914,
-0.00959567166864872,
-0.049224622547626495,
-0.011004005558788776,
-0.030089164152741432,
0.01401627529412508,
0.007214916869997978,
-0.018666012212634087,
-0.03520834818482399,
-0.02926204726099968,
0.017347097396850586,
0.014888101257383823,
-0.012663827277719975,
0.038159143179655075,
-0.026266545057296753,
-0.01726885512471199,
0.032324615865945816,
0.02539471909403801,
-0.0017073253402486444,
-0.008936213329434395,
0.018062440678477287,
0.0038170318584889174,
0.0053986129350960255,
-0.0054572937078773975,
-0.05101298168301582,
0.010607212781906128,
-0.018464822322130203,
0.0068125356920063496,
-0.027831358835101128,
-0.005429350771009922,
-0.0046273828484117985,
0.03706376999616623,
0.03252580761909485,
0.008036444894969463,
0.009461544454097748,
-0.007572588976472616,
0.010227186605334282,
-0.01657586544752121,
0.04090874642133713,
0.00016800808953121305,
-0.006834890227764845,
0.014474542811512947,
-0.028233740478754044,
-0.00796379242092371,
-0.038203850388526917,
-0.024545246735215187,
-0.00686283316463232,
-0.013870971277356148,
0.01919134333729744,
-0.005102416034787893,
-0.015178709290921688,
0.005538329016417265,
0.011439918540418148,
-0.001648644800297916,
0.006840478628873825,
-0.00819292664527893,
-0.011892597191035748,
-0.00979127362370491,
-0.0032805236987769604,
0.013211512938141823,
0.01024395227432251,
0.03167633339762688,
0.0004998327931389213,
-0.010188066400587559,
0.009495076723396778,
-0.018442466855049133,
-0.014273351989686489,
0.019113102927803993,
0.014161579310894012,
0.0016290845815092325,
-0.023852257058024406,
0.00316036818549037,
0.010266306810081005,
-0.015446963720023632,
0.01666528359055519,
0.029709137976169586,
-0.004987848922610283,
-0.015491672791540623,
0.03368823975324631,
-0.01713472791016102,
-0.021147362887859344,
0.0065889908000826836,
-0.005320372525602579,
-0.003724819514900446,
-0.006583401933312416,
-0.01789478212594986,
-0.03189988061785698,
-0.015659330412745476,
0.0021935359109193087,
0.017883604392409325,
-0.060312457382678986,
0.007969381287693977,
0.011166075244545937,
-0.005739519372582436,
-0.01432923786342144,
-0.0020538202952593565,
-0.030446836724877357,
-0.03312937915325165,
-0.005426556337624788,
0.003942776005715132,
-0.02928440272808075,
-0.04540200158953667,
-0.015301658771932125,
0.011400798335671425,
0.03192223608493805,
-0.02143797092139721,
0.003691287711262703,
0.05584155395627022,
0.04841985926032066,
-0.038718003779649734,
0.01648644730448723,
0.00751111377030611,
0.0036605503410100937,
-0.013401526026427746,
-0.032928187400102615,
0.021717403084039688,
-0.008662370964884758,
0.032928187400102615,
0.0016472477000206709,
0.019727852195501328,
-0.007645240984857082,
-0.028345514088869095,
-0.0015997443115338683,
0.014407479204237461,
-0.003610252635553479,
0.022611582651734352,
0.015145177952945232,
-0.002639228943735361,
-0.005021380726248026,
-0.027697233483195305,
-0.03433652222156525,
0.03849446028470993,
0.028882021084427834,
0.021840352565050125,
0.015715217217803,
0.030826862901449203,
0.038136787712574005,
0.000982899684458971,
-0.028479639440774918,
0.010774871334433556,
0.009930988773703575,
0.0027761501260101795,
0.00795261561870575,
0.002540030749514699,
0.007762602064758539,
-0.032279904931783676,
0.010769283398985863,
0.0006751759210601449,
-0.030178582295775414,
-0.01726885512471199,
-0.01432923786342144,
0.009467133320868015,
0.00039469674811698496,
0.004755921196192503,
-0.013267398811876774,
0.015245772898197174,
-0.025215882807970047,
0.004314419813454151,
-0.019850801676511765,
0.0009808039758354425,
-0.01690000668168068,
0.021147362887859344,
-0.01845364458858967,
-0.032302260398864746,
0.011490215547382832,
0.018408935517072678,
-0.04113228991627693,
-0.006566636264324188,
-0.03471654653549194,
-0.011300202459096909,
-0.027786649763584137,
-0.01172493863850832,
-0.028457285836338997,
-0.01466455589979887,
0.01009305939078331,
0.003498480189591646,
-0.025260591879487038,
-0.021907415241003036,
0.010389256291091442,
0.008025267161428928,
-0.03985808417201042,
-0.005035352427512407,
-0.001283986959606409,
0.001325901597738266,
0.022879837080836296,
0.00924917683005333,
-0.006074836943298578,
-0.0035571607295423746,
-0.03330821543931961,
-0.016519980505108833,
0.01093694195151329,
0.025841807946562767,
0.00350406882353127,
-0.02122560329735279,
0.010562503710389137,
-0.03393413871526718,
-0.006600167602300644,
-0.06330796331167221,
-0.010568092577159405,
0.008142628706991673,
-0.01726885512471199,
-0.024388765916228294,
-0.009008865803480148,
-0.02537236362695694,
-0.003722025314345956,
0.0057562850415706635,
-0.013122094795107841,
-0.04122170805931091,
-0.0002045088040176779,
0.003828209126368165,
0.0012274021282792091,
0.04935874789953232,
-0.022701000794768333,
0.012909727171063423,
-0.0044597238302230835,
0.04043930023908615,
0.009159758687019348,
-0.022298619151115417,
0.028256095945835114,
-0.001577389775775373,
-0.015871699899435043,
0.006577813532203436,
-0.00696901697665453,
-0.022320974618196487,
-0.02289101481437683,
-0.03194458782672882,
-0.010808403603732586,
0.019850801676511765,
0.025104109197854996,
0.010327781550586224,
-0.0033028782345354557,
0.0260429996997118,
0.0009912826353684068,
-0.007762602064758539,
-0.007768190931528807,
0.009008865803480148,
0.0018819699762389064,
-0.03641549125313759,
-0.014150402508676052,
-0.001417415332980454,
-0.02861376665532589,
0.010629567317664623,
0.0027859301771968603,
-0.021259134635329247,
0.02219802513718605,
-0.01172493863850832,
-0.008187337778508663,
0.005840114783495665,
-0.0226898230612278,
0.009120638482272625,
0.007444050628691912,
-0.011261082254350185,
-0.0024841444101184607,
0.011601988226175308,
0.005951886996626854,
0.006186609622091055,
0.036773163825273514,
0.027652524411678314,
-0.007186973467469215,
0.02409815788269043,
0.007248448673635721,
-0.025886517018079758,
-0.020689094439148903,
-0.01297679077833891,
0.13117623329162598,
0.015569913201034069,
0.017537109553813934,
0.002108309417963028,
-0.014988696202635765,
-0.018353048712015152,
0.019739028066396713,
0.007388164289295673,
0.007365809753537178,
-0.019772561267018318,
-0.008578541688621044,
0.009333006106317043,
0.03344234079122543,
0.014128047972917557,
0.008220869116485119,
-0.018856026232242584,
0.005485236644744873,
0.041400544345378876,
-0.004333979915827513,
-0.02671363390982151,
-0.02333810366690159,
0.012272623367607594,
-0.006561047397553921,
0.01778300851583481,
-0.029016148298978806,
-0.00766200665384531,
-0.006046894006431103,
0.007108733057975769,
0.03449300304055214,
-0.00465253135189414,
-0.002727249637246132,
0.023628711700439453,
0.011792002245783806,
-0.030983345583081245,
-0.0006294190534390509,
0.0006702858954668045,
-0.007080789655447006,
-0.008572952821850777,
0.031050408259034157,
-0.005923944059759378,
0.013658602721989155,
-0.002257805084809661,
0.014005097560584545,
-0.00032134601497091353,
0.044485464692115784,
-0.0027118809521198273,
-0.006398977246135473,
-0.02550649084150791,
-0.01057927031069994,
0.0008732228889130056,
-0.03053625486791134,
0.008925036527216434,
0.01333446241915226,
-0.00480342423543334,
-0.040014564990997314,
-0.0403275266289711,
0.0008571555954404175,
-0.011166075244545937,
-0.022488633170723915,
-0.025864163413643837,
-0.04962700232863426,
-0.007723481860011816,
0.01122755091637373,
0.006069248542189598,
-0.0034202393144369125
] | 2025-01-02 | 1 | 39743260 | [
"severe CRS",
"fever characteristics",
"CRS",
"chimeric antigen receptor T cell",
"serum biomarkers",
"Patients",
"patients",
"Xuzhou Medical University",
"cytokine release syndrome",
"104 R/R MM patients",
"fever",
"(R/R MM",
"a clinical characteristic",
"the clinical characteristics",
"their clinical characteristics",
"CAR-T cell therapy",
"Long duration",
"June",
"high-risk cytogenetics",
"November",
"CAR-T treatment",
"relapsed/refractory multiple myeloma",
"no CRS",
"the Affiliated Hospital of Xuzhou Medical University",
"CAR-T",
"CRS (\nHigh-risk cytogenetics",
"a higher risk",
"a risk factor",
"CRP",
"复发难治性多发性骨髓瘤患者CAR"
] | [
"chimeric antigen receptor T cells; multiple myeloma; cytokine release syndrome; fever"
] | 0 | 10.19746/j.cnki.issn.1009-2137.2024.06.017 | [
"Hua",
"Wang",
"Ji",
"Liu",
"Chen",
"Shao",
"Cheng",
"Cao"
] | [
"Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.",
"Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.",
"Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.",
"Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.",
"Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.",
"Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.",
"Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.",
"Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China."
] | [
"39743260"
] | [] | 5.3198 | 5.282726 |
39739533 | 89 | Protocol for production of tonic CAR T cells with dasatinib. | Chimeric antigen receptors (CARs) are synthetic molecules composed of an extracellular antigen-binding domain and an intracellular signaling domain, leading to tonic signaling and manufacturing challenges. We present a protocol for the expansion of tonic CARs by using a Food and Drug Administration (FDA)-approved kinase inhibitor, dasatinib. We report steps for T cell transduction with retrovirus, expansion and verification of CAR quality using flow cytometry, and killing assay. At only 30 nM, dasatinib improves tonic CAR T cell proliferation and quality after expansion. For complete details on the use and execution of this protocol, please refer to Caulier et al. | [
0.01995864138007164,
-0.0014919762033969164,
0.025594312697649002,
0.034355442970991135,
-0.0319436714053154,
0.011591270565986633,
-0.02591424062848091,
0.010514586232602596,
-0.036865655332803726,
-0.026111120358109474,
0.010016235522925854,
-0.02165672555565834,
-0.0376039519906044,
-0.036865655332803726,
0.04550373554229736,
-0.03049168549478054,
0.02164442092180252,
0.007352212443947792,
-0.00400218740105629,
0.03994189202785492,
0.006743116769939661,
-0.002659409074112773,
0.0069092339836061,
0.029581118375062943,
-0.013449318706989288,
0.01796523854136467,
0.03713636472821236,
0.0021487532649189234,
0.006069420371204615,
-0.05241912230849266,
0.005749491509050131,
-0.03110693395137787,
-0.04855536296963692,
-0.030097927898168564,
-0.00781980063766241,
0.034010905772447586,
0.007444499526172876,
0.0010420761536806822,
-0.03482303023338318,
-0.03853913024067879,
0.04956436902284622,
-0.006780032068490982,
0.013584673404693604,
0.07560165971517563,
-0.056012168526649475,
-0.00013285510067362338,
-0.05994975566864014,
-0.023551689460873604,
0.008816502057015896,
0.008601165376603603,
-0.06812024861574173,
-0.00428520143032074,
-0.0313776433467865,
0.0310331042855978,
-0.05817783996462822,
0.040040332823991776,
-0.01652555912733078,
0.006020200904458761,
-0.05212380364537239,
0.02761232666671276,
0.01768222451210022,
-0.006613914854824543,
-0.0025317450053989887,
-0.014901303686201572,
-0.060294292867183685,
0.01824825257062912,
-0.06679131090641022,
0.026283390820026398,
0.02704629860818386,
0.07284535467624664,
0.013769247569143772,
-0.00030570130911655724,
-0.010686855763196945,
-0.004980431869626045,
0.03159913048148155,
-0.0023148702457547188,
-0.03054090589284897,
0.059998974204063416,
0.021299881860613823,
0.018765060231089592,
0.01593491993844509,
-0.016402509063482285,
-0.003003947902470827,
-0.04011416435241699,
-0.01213268842548132,
-0.02938424050807953,
0.01742381975054741,
-0.046340472996234894,
0.0012850990751758218,
-0.026554100215435028,
-0.0009174884180538356,
0.02534821256995201,
-0.03898210823535919,
0.04299352318048477,
-0.020438535138964653,
0.06329670548439026,
-0.04321501404047012,
-0.008982619270682335,
0.029211970046162605,
0.013387794606387615,
0.08874335885047913,
0.009167193435132504,
-0.011068309657275677,
-0.0021764393895864487,
0.034626152366399765,
0.022308889776468277,
-0.053403519093990326,
0.01741151511669159,
0.03588125854730606,
-0.02822757326066494,
0.07889939099550247,
-0.022456549108028412,
0.019515663385391235,
0.04227983579039574,
-0.021275272592902184,
-0.06511783599853516,
0.02137371152639389,
-0.01885119639337063,
-0.03019636683166027,
0.0017596089746803045,
-0.027587715536355972,
0.02136140689253807,
0.060294292867183685,
-0.01213268842548132,
-0.01849435269832611,
-0.012612582184374332,
0.08136038482189178,
-0.02110300213098526,
-0.026012681424617767,
-0.05955599620938301,
0.017485344782471657,
-0.019281869754195213,
0.027144737541675568,
0.004414403811097145,
-0.016685523092746735,
-0.0202785711735487,
-0.03511834889650345,
-0.006007895804941654,
-0.03851451724767685,
0.011259036138653755,
0.03051629662513733,
0.002525592688471079,
0.001516586053185165,
-0.014987438917160034,
-0.02734161727130413,
-0.03812076151371002,
-0.026972467079758644,
0.03044246695935726,
-0.012378787621855736,
0.05615982785820961,
-0.014716729521751404,
0.058030180633068085,
0.0422552265226841,
0.007081503514200449,
0.004497461952269077,
-0.053108200430870056,
-0.03270657733082771,
0.009991626255214214,
-0.020290875807404518,
-0.04227983579039574,
-0.010071608237922192,
0.012661801651120186,
-0.009044144302606583,
-0.018998855724930763,
-0.01849435269832611,
-0.0029977953527122736,
0.012083468958735466,
0.015295063145458698,
-0.06851400434970856,
0.017042366787791252,
-0.03474920243024826,
0.00022225829889066517,
-0.03925281763076782,
-0.005057337693870068,
-0.04730025678873062,
0.006281680893152952,
-0.01239724550396204,
0.03541366755962372,
-0.04353494197130203,
-0.02165672555565834,
0.00810896698385477,
-0.013916907832026482,
0.05241912230849266,
-0.0013743099989369512,
0.011295951902866364,
0.00413446594029665,
-0.023440945893526077,
-0.0018903492018580437,
0.005715652834624052,
-0.04850614443421364,
0.010434604249894619,
0.016439422965049744,
0.04611898213624954,
0.01709158718585968,
-0.009154888801276684,
-0.03708714246749878,
0.04540529474616051,
0.027735374867916107,
-0.006675439886748791,
-0.02822757326066494,
-0.021841300651431084,
-0.04816160723567009,
-0.040040332823991776,
-0.01023772545158863,
-0.029704168438911438,
-0.016131799668073654,
-0.035462889820337296,
0.029482679441571236,
-0.012563361786305904,
0.0012274195905774832,
0.05985131487250328,
-0.00985011924058199,
-0.020081691443920135,
0.013437014073133469,
-0.03538905829191208,
-0.009751679375767708,
0.0027916873805224895,
0.018666621297597885,
0.000010514490895729978,
-0.011197512038052082,
-0.026923248544335365,
-0.0005283441278152168,
-0.01822364330291748,
-0.01827286183834076,
-0.05281287804245949,
0.0028455215506255627,
-0.002488677855581045,
-0.02110300213098526,
0.007856715470552444,
-0.0028932031709700823,
-0.024142326787114143,
0.00046297404333017766,
0.017792969942092896,
-0.021595200523734093,
-0.07127031683921814,
0.01739921048283577,
0.04427323862910271,
-0.0002532129583414644,
0.06497018039226532,
-0.034010905772447586,
0.013289354741573334,
0.010914498008787632,
0.020635414868593216,
0.0047866287641227245,
0.007026130799204111,
0.007204553112387657,
-0.018162118270993233,
-0.05620904639363289,
-0.006109411828219891,
-0.00825662724673748,
0.01070531364530325,
0.028547503054142,
0.017522260546684265,
0.000059169542510062456,
0.020340096205472946,
0.022161228582262993,
0.02052466943860054,
-0.015873394906520844,
-0.019724847748875618,
-0.005709500517696142,
0.008145881816744804,
0.0159718357026577,
-0.00598328560590744,
-0.032091330736875534,
-0.02510211430490017,
0.04218139499425888,
-0.006177088711410761,
0.014433715492486954,
0.0018042144365608692,
-0.014605985023081303,
0.038046929985284805,
0.02255498804152012,
0.02275186777114868,
-0.01240955013781786,
-0.04368260130286217,
-0.0008874951163306832,
0.012747936882078648,
0.05394493415951729,
0.00690308166667819,
0.03765317052602768,
-0.018715841695666313,
0.011757387779653072,
-0.006152478978037834,
-0.011492830701172352,
-0.017534565180540085,
-0.010323859751224518,
0.03105771355330944,
-0.044322457164525986,
0.014495240524411201,
0.023748569190502167,
-0.003117768792435527,
-0.008428895846009254,
-0.03051629662513733,
-0.04651274159550667,
-0.01683318242430687,
0.0021948968060314655,
-0.037480901926755905,
0.0008167416090145707,
-0.0227641724050045,
-0.014901303686201572,
-0.03167296200990677,
0.0433872826397419,
-0.02340403012931347,
-0.038908276706933975,
-0.011763540096580982,
0.05099174752831459,
0.03447849303483963,
0.002640951657667756,
0.06182010844349861,
0.05276365950703621,
0.025594312697649002,
-0.0009644010569900274,
0.04725103825330734,
-0.0063862730748951435,
0.0394250862300396,
0.00967784970998764,
0.02768615633249283,
-0.041172388941049576,
0.03561054915189743,
-0.03789927065372467,
-0.02139832265675068,
-0.019774068146944046,
-0.024745270609855652,
0.003617657581344247,
0.015873394906520844,
-0.04853075370192528,
0.013769247569143772,
-0.02682480774819851,
0.01052073948085308,
-0.035462889820337296,
0.014753644354641438,
-0.021755166351795197,
0.040311042219400406,
-0.010976022109389305,
0.0016380975721403956,
0.012907900847494602,
-0.00913643091917038,
-0.08185257762670517,
0.014187616296112537,
0.034380052238702774,
-0.017005452886223793,
0.03398629277944565,
-0.017325380817055702,
0.038588348776102066,
0.014482935890555382,
0.017276160418987274,
0.004275972954928875,
-0.006014048121869564,
-0.006558542605489492,
0.010157742537558079,
-0.007524481974542141,
0.016697827726602554,
0.019798677414655685,
-0.010373079217970371,
0.0077029038220644,
0.012649497017264366,
-0.040015723556280136,
0.009450207464396954,
0.0028747457545250654,
-0.023810094222426414,
0.008195102214813232,
0.02566814236342907,
-0.015627296641469002,
0.028842821717262268,
0.025249773636460304,
0.07579854130744934,
-0.039745014160871506,
0.028006084263324738,
-0.02476987987756729,
-0.002036470454186201,
-0.021496761590242386,
-0.01706697605550289,
-0.0025471262633800507,
0.01763300411403179,
-0.010969869792461395,
0.017054671421647072,
0.04223061725497246,
0.029458070173859596,
0.025298994034528732,
-0.03243586793541908,
0.04557756334543228,
-0.02879360131919384,
-0.02342863939702511,
-0.007610616739839315,
0.022370412945747375,
0.04011416435241699,
0.03499529883265495,
0.01966332271695137,
-0.04227983579039574,
0.0387360081076622,
0.0012881752336397767,
-0.01741151511669159,
0.03140225261449814,
-0.013707723468542099,
-0.042895082384347916,
0.04368260130286217,
-0.009013381786644459,
0.057144224643707275,
0.041467707604169846,
0.02591424062848091,
0.022911831736564636,
-0.049170613288879395,
0.008385828696191311,
-0.02337942086160183,
0.03442927077412605,
-0.014470630325376987,
0.036028917878866196,
-0.007118418347090483,
0.006577000021934509,
-0.01734999008476734,
0.021447541192173958,
0.004131389781832695,
0.03986806422472,
-0.019011160358786583,
0.029728777706623077,
-0.01734999008476734,
-0.026578709483146667,
0.05222224071621895,
-0.024400731548666954,
0.04570061340928078,
0.021853605285286903,
-0.06600379198789597,
0.01648864336311817,
-0.04988430067896843,
-0.007130722980946302,
0.024868320673704147,
-0.006041734479367733,
0.004165228456258774,
0.006810794118791819,
-0.01655016839504242,
0.0008267393568530679,
0.02136140689253807,
0.01572573557496071,
-0.020303180441260338,
-0.007887477986514568,
0.022382719442248344,
-0.0347738116979599,
-0.010286944918334484,
-0.03954813629388809,
0.023859312757849693,
-0.03669338300824165,
-0.007019978482276201,
0.016402509063482285,
-0.010022387839853764,
0.007038435898721218,
0.01410148199647665,
-0.0021533677354454994,
0.004863534588366747,
-0.029015090316534042,
-0.017854494974017143,
-0.06014663353562355,
-0.05192692205309868,
-0.031205372884869576,
0.016919316723942757,
-0.05296054109930992,
-0.003814537078142166,
0.016057970002293587,
-0.016993146389722824,
-0.023244066163897514,
0.01523353811353445,
0.04075402021408081,
-0.016870098188519478,
0.018592791631817818,
-0.02569275163114071,
-0.01907268539071083,
0.0661514550447464,
0.022419633343815804,
0.004657426383346319,
0.022395024076104164,
-0.040286432951688766,
-0.024646831676363945,
-0.015787260606884956,
-0.01080375351011753,
0.05251755937933922,
-0.023182541131973267,
0.032903458923101425,
0.03991728276014328,
-0.0036545724142342806,
0.018112897872924805,
0.038908276706933975,
-0.03484763950109482,
0.005238835699856281,
-0.029827218502759933,
0.018728146329522133,
0.03932664543390274,
0.0645764172077179,
0.0038852905854582787,
-0.02903970144689083,
-0.02079537883400917,
0.01826055720448494,
-0.017030062153935432,
-0.013707723468542099,
-0.0024348434526473284,
-0.012175755575299263,
-0.006515475455671549,
-0.0126864118501544,
0.005860236473381519,
0.0037468597292900085,
-0.020746158435940742,
0.013916907832026482,
-0.001711927237920463,
0.05217302218079567,
0.009899338707327843,
0.013350879773497581,
0.046315863728523254,
0.030614735558629036,
0.015307367779314518,
0.07732435315847397,
-0.007530634291470051,
0.029458070173859596,
-0.014187616296112537,
-0.013621588237583637,
0.03501991182565689,
-0.006589305121451616,
-0.040606360882520676,
-0.027563106268644333,
-0.06506861746311188,
-0.04193529859185219,
0.0011282108025625348,
-0.011123682372272015,
-0.038957495242357254,
-0.014273751527071,
-0.02736622653901577,
0.013596978969871998,
0.018125202506780624,
-0.025298994034528732,
-0.00857040286064148,
-0.037185583263635635,
-0.024314597249031067,
-0.030983883887529373,
0.019478747621178627,
-0.0008874951163306832,
0.018432827666401863,
0.011295951902866364,
-0.002717857714742422,
0.003611505264416337,
-0.028867430984973907,
0.05448635295033455,
0.0046451217494904995,
-0.037259411066770554,
-0.009708612225949764,
-0.010477671399712563,
-0.004008340183645487,
-0.039449695497751236,
-0.00810896698385477,
-0.005368038080632687,
0.003980653826147318,
-0.03174678981304169,
0.011185206472873688,
0.002734776819124818,
0.025175943970680237,
-0.013178610242903233,
0.0015127407386898994,
-0.0006306290742941201,
-0.012637191452085972,
-0.008121272549033165,
-0.0071245706640183926,
-0.025815801694989204,
-0.006220156326889992,
-0.021004563197493553,
-0.005641823168843985,
0.009610172361135483,
0.010772990994155407,
-0.040926288813352585,
-0.045479126274585724,
0.004823543597012758,
-0.008705757558345795,
0.005014270544052124,
-0.04648813232779503,
0.01280946098268032,
-0.026037290692329407,
0.008914941921830177,
0.012637191452085972,
-0.017300771549344063,
0.0472264289855957,
0.013609283603727818,
-0.004881992004811764,
0.017534565180540085,
-0.0044790045358240604,
0.04109856113791466,
-0.023440945893526077,
-0.03218977153301239,
-0.005057337693870068,
0.04510997608304024,
-0.04333806037902832,
0.026923248544335365,
-0.038588348776102066,
-0.02938424050807953,
-0.015184317715466022,
0.0028670551255345345,
-0.016660913825035095,
0.019491054117679596,
0.050327278673648834,
0.04934288188815117,
-0.020007861778140068,
-0.0024348434526473284,
-0.013941517099738121,
-0.011339019052684307,
-0.010723770596086979,
0.020044775679707527,
0.023551689460873604,
-0.0075675491243600845,
0.0006410114001482725,
-0.055421531200408936,
-0.03132842481136322,
0.02227197401225567,
-0.02879360131919384,
-0.006786184385418892,
-0.01798984780907631,
-0.0029070463497191668,
0.032066721469163895,
0.014765949919819832,
-0.01455676555633545,
-0.007807496003806591,
-0.006503170356154442,
0.020426230505108833,
-0.04151692986488342,
-0.0019380309386178851,
0.011861979961395264,
-0.04936749115586281,
-0.005054261535406113,
0.015135098248720169,
-0.02080768346786499,
0.00025032900157384574,
-0.016131799668073654,
0.00413446594029665,
0.011511288583278656,
-0.008644233457744122,
-0.021176831796765327,
-0.0024056192487478256,
-0.021472152322530746,
-0.017288466915488243,
-0.0008744210936129093,
0.011498983018100262,
-0.013424709439277649,
-0.029777998104691505,
0.030368635430932045,
-0.014852084219455719,
0.00320236524567008,
0.01568882167339325,
-0.0011089843465015292,
0.0033377199433743954,
0.01111752912402153,
-0.05123784393072128,
0.017534565180540085,
-0.004349802620708942,
-0.027292396873235703,
0.006134021561592817,
0.010003930889070034,
-0.005454172845929861,
-0.013966127298772335,
-0.01913421042263508,
0.013978431932628155,
-0.028326014056801796,
0.007745970971882343,
-0.006183241493999958,
-0.012514142319560051,
-0.001768837682902813,
0.03991728276014328,
0.06428109854459763,
-0.017337685450911522,
0.027759985998272896,
0.008453506045043468,
-0.037505511194467545,
-0.01711619645357132,
0.018617400899529457,
0.04875224456191063,
0.014544459991157055,
0.005481858737766743,
0.008490420877933502,
0.12373866140842438,
0.016082579270005226,
-0.009321006014943123,
-0.04045870155096054,
0.008859570138156414,
0.007727513555437326,
0.00023071796749718487,
-0.02051236480474472,
-0.02420385181903839,
-0.00563259469345212,
0.012514142319560051,
0.027809204533696175,
-0.027218567207455635,
-0.009745527058839798,
0.009062601253390312,
-0.00997316837310791,
0.005912532098591328,
0.025225164368748665,
-0.002304103458300233,
-0.006130945403128862,
-0.021250663325190544,
-0.006939996499568224,
-0.024979064241051674,
-0.010877583175897598,
0.0072722299955785275,
0.0049312119372189045,
0.014470630325376987,
-0.006533932872116566,
-0.01997094601392746,
-0.030590126290917397,
0.028424452990293503,
0.013227829709649086,
0.02047545090317726,
-0.026701759546995163,
0.01854357123374939,
-0.0193680040538311,
-0.00013948824198450893,
-0.034946080297231674,
0.00826277956366539,
0.011369781568646431,
0.020573889836668968,
0.00662006763741374,
-0.03312494605779648,
-0.01714080572128296,
0.011215968988835812,
-0.000028383115932228975,
0.010231572203338146,
0.03876061737537384,
0.014852084219455719,
0.019860202446579933,
0.00009834353113546968,
0.020327789708971977,
-0.03984345495700836,
-0.003956044092774391,
0.03312494605779648,
0.014519850723445415,
-0.00856425054371357,
0.06585613638162613,
-0.016193324699997902,
0.013904602266848087,
-0.021176831796765327,
-0.008459658361971378,
-0.00938868336379528,
-0.002008784329518676,
-0.036102745682001114,
-0.0302455872297287,
-0.015381197445094585,
-0.009782441891729832,
-0.027563106268644333,
-0.011788149364292622,
0.008422743529081345,
-0.010360774584114552,
-0.026923248544335365,
0.021459847688674927,
-0.01908499002456665,
0.012003486976027489,
0.03285423666238785,
-0.04353494197130203,
0.002234888030216098,
-0.047201819717884064,
0.0018626629607751966,
0.009222566150128841,
-0.032362040132284164,
-0.0060878777876496315,
0.02161981165409088,
-0.026012681424617767,
-0.0029901047237217426,
-0.006137097720056772,
0.0012189599219709635,
-0.015553466975688934,
-0.04424862936139107,
-0.04077862948179245,
-0.007450651843100786,
0.022628817707300186,
0.004872763529419899,
0.017743749544024467,
-0.00186881551053375,
-0.005174234975129366,
-0.04353494197130203,
0.04725103825330734,
-0.015787260606884956,
-0.0005798711208626628,
-0.000047393314162036404,
-0.004731256514787674,
0.020893817767500877,
0.01185582671314478,
-0.04102472960948944,
0.026923248544335365,
0.02422846294939518,
0.01765761524438858,
-0.051188625395298004,
-0.0011835831683129072,
-0.009825509041547775,
0.05675046518445015,
0.014827474020421505,
-0.008798045106232166,
-0.013166304677724838,
0.021213747560977936,
-0.024585306644439697,
0.009868576191365719,
-0.017768358811736107,
0.0287689920514822,
-0.04727564752101898,
0.018642012029886246,
0.009037991985678673,
0.03469998016953468,
0.039474304765462875,
-0.0634443610906601,
-0.0518777035176754,
0.009628629311919212,
0.0008190487860701978,
-0.012784851714968681,
0.017226941883563995,
0.002770153572782874,
-0.009296395815908909,
0.017768358811736107,
-0.03359253704547882,
0.018482046201825142,
-0.0016211782349273562,
0.02704629860818386,
0.02422846294939518,
0.00748141435906291,
-0.01770683377981186,
-0.03767777979373932,
-0.057734861969947815,
-0.007210705429315567,
0.04483926668763161,
0.020167825743556023,
-0.010397689417004585,
-0.013117085210978985,
0.027513885870575905,
0.025298994034528732,
0.006460102740675211,
0.011991181410849094,
0.002081075916066766,
-0.046340472996234894,
-0.005577222444117069,
0.029851827770471573,
0.008705757558345795,
-0.03876061737537384,
0.027267787605524063,
-0.027833815664052963,
-0.043190401047468185,
0.04102472960948944,
-0.018617400899529457,
0.012932511046528816,
0.0014073795173317194,
0.024080803617835045,
-0.012507990002632141,
0.0018103669863194227,
0.006927691400051117,
0.000025955770979635417,
0.007782885804772377,
-0.03595508635044098,
-0.024413036182522774,
0.022062789648771286,
-0.009437902830541134,
0.04274742305278778,
-0.009813204407691956,
-0.03501991182565689,
0.005647975951433182,
0.0020887665450572968,
0.03132842481136322,
0.006149402819573879,
0.02452378161251545,
0.01939261332154274,
0.019441833719611168,
-0.01213268842548132,
0.06285372376441956,
0.030663955956697464,
-0.01053919643163681,
0.022050485014915466,
-0.01881428062915802,
-0.04953975975513458,
-0.004842001013457775,
-0.004949669353663921,
0.02512672357261181,
-0.01324013527482748,
-0.004722027573734522,
-0.03474920243024826,
0.020586194470524788,
-0.01851896196603775,
0.00455591082572937,
-0.03612735494971275,
-0.002927041845396161,
0.018678925931453705,
0.02987643890082836,
-0.00526036974042654,
-0.01563960127532482,
-0.024979064241051674,
-0.009591714479029179,
-0.03366636484861374,
0.006373968441039324,
-0.008330456912517548,
0.009456359781324863,
0.007216857746243477,
0.01883888989686966,
0.00826277956366539,
-0.002234888030216098,
-0.04242749512195587,
-0.010939107276499271,
-0.0017257704166695476,
-0.033740196377038956,
-0.041763026267290115,
0.0071553331799805164,
-0.00008565404277760535,
-0.018285168334841728,
0.027464665472507477,
-0.0055433837696909904,
-0.0007409891695715487,
-0.04953975975513458,
-0.027021687477827072,
-0.0039191292598843575,
0.03361714631319046,
0.01054534874856472,
-0.016390204429626465,
-0.04417479783296585,
0.037259411066770554,
0.006312443409115076,
0.03563515841960907,
-0.024671440944075584,
-0.012514142319560051,
0.059998974204063416,
0.017817579209804535,
0.013043255545198917,
0.01354775857180357,
-0.009480969980359077,
0.032337430864572525,
0.0004175995127297938,
-0.04252593591809273,
-0.007001521065831184,
-0.03216515854001045,
-0.0029147369787096977,
0.002520978217944503,
0.035487499088048935,
0.004537453409284353,
-0.017042366787791252,
0.014126092195510864,
-0.0016688599716871977,
0.012194213457405567,
-0.005992514546960592,
0.0012397245736792684,
0.035241398960351944,
0.03214054927229881,
0.03332182765007019,
-0.005641823168843985,
0.022714952006936073,
-0.012065011076629162,
-0.005198844708502293,
0.027218567207455635,
-0.009819356724619865,
0.02987643890082836,
-0.003549980465322733,
-0.05960521474480629,
0.02308410033583641,
-0.02965494804084301,
0.0056448993273079395,
-0.02105378359556198,
0.013707723468542099,
0.019810982048511505,
0.03164835274219513,
-0.009468665346503258,
0.031476084142923355,
-0.009493275545537472,
-0.033198777586221695,
-0.01792832463979721,
0.025865022093057632,
-0.010317707434296608,
0.03984345495700836,
-0.010877583175897598,
0.004968126770108938,
0.022714952006936073,
0.003053167602047324,
-0.016685523092746735,
-0.0028332166839390993,
0.028596721589565277,
0.053698837757110596,
0.0456513948738575,
-0.07107343524694443,
0.0376039519906044,
-0.007801343221217394,
-0.02795686386525631,
-0.016660913825035095,
0.018100593239068985,
0.002097995253279805,
0.015541162341833115,
0.03314955532550812,
-0.05236990004777908,
-0.011769692413508892,
0.024314597249031067,
0.020869208499789238,
0.026874028146266937,
-0.02019243687391281,
-0.001696546096354723,
-0.018408216536045074,
0.012034248560667038,
0.016316374763846397,
-0.04442089796066284,
-0.032362040132284164,
0.0012343410635367036,
0.0399911142885685,
0.022702647373080254,
-0.017300771549344063,
-0.00008262586925411597,
0.0036053527146577835,
-0.014753644354641438,
-0.031476084142923355,
-0.030639344826340675,
0.020093996077775955,
0.029482679441571236,
-0.0034976843744516373,
0.00022783398162573576,
-0.007598311640322208,
0.018605096265673637,
-0.02652948908507824,
0.00512809120118618,
0.0426982045173645,
-0.008662690408527851,
0.021447541192173958,
-0.025422044098377228,
0.034084733575582504,
0.014507545158267021,
0.00042567463242448866,
0.026332609355449677,
0.011215968988835812,
-0.03223899006843567,
-0.03223899006843567,
-0.06078649312257767,
-0.0399911142885685,
0.0011666638310998678,
-0.02337942086160183,
-0.0049588982947170734,
-0.004005264025181532,
0.016414813697338104,
0.010077760554850101,
-0.01041614729911089,
0.022345803678035736,
-0.02110300213098526,
0.016304070129990578,
0.004752790089696646,
0.014458325691521168,
0.020955342799425125,
-0.006706201937049627,
-0.01853126659989357,
-0.0037191736046224833,
0.025815801694989204,
-0.006417035590857267,
0.01523353811353445,
-0.0033038812689483166,
-0.012181908823549747,
-0.021226052194833755,
-0.02369934879243374,
0.013683113269507885,
0.03278040885925293,
-0.017817579209804535,
-0.01026848703622818,
0.007346060127019882,
-0.018974244594573975,
-0.0030670107807964087,
0.016636302694678307,
0.023293284699320793,
0.05281287804245949,
0.022358108311891556,
-0.0025548168923705816,
0.025815801694989204,
0.016747048124670982,
-0.015738042071461678,
-0.005820245016366243,
0.03201749920845032,
-0.0020687710493803024,
-0.0021841300185769796,
0.013141695410013199,
-0.01910959929227829,
0.004485157318413258,
-0.024880625307559967,
-0.035832036286592484,
0.05729188397526741,
0.041172388941049576,
0.017780663445591927,
0.0074137370102107525,
-0.011252883821725845,
0.011972724460065365,
-0.015873394906520844,
0.03794848918914795,
-0.018617400899529457,
-0.013289354741573334,
-0.001253567636013031,
0.0035592091735452414,
-0.017596090212464333,
-0.034946080297231674,
0.014888999052345753,
0.013941517099738121,
-0.01714080572128296,
-0.015479637309908867,
0.015504247508943081,
0.0056695095263421535,
-0.012089621275663376,
-0.014224531129002571,
-0.013424709439277649,
0.0005148855852894485,
-0.030688565224409103,
-0.012711022049188614,
-0.018912719562649727,
0.008810349740087986,
0.007038435898721218,
0.016882402822375298,
0.0032915761694312096,
0.018432827666401863,
0.017460735514760017,
-0.028842821717262268,
-0.024376122280955315,
0.023736264556646347,
-0.008718063123524189,
-0.0020241655874997377,
-0.03597969561815262,
0.046291250735521317,
0.016402509063482285,
-0.0405571423470974,
-0.010065455920994282,
0.006663134787231684,
0.010157742537558079,
0.03428161144256592,
0.018039068207144737,
-0.02511441893875599,
0.035241398960351944,
-0.009493275545537472,
-0.004642045591026545,
-0.03393707424402237,
0.012058858759701252,
0.03164835274219513,
-0.0072968401946127415,
-0.022874917834997177,
0.010557654313743114,
-0.008951856754720211,
0.0013504691887646914,
0.009727069176733494,
-0.0021195290610194206,
0.026578709483146667,
-0.01600874960422516,
-0.00004071210787515156,
0.02652948908507824,
-0.018371302634477615,
-0.0041898381896317005,
-0.020167825743556023,
-0.014618289656937122,
0.0231087114661932,
0.021472152322530746,
-0.0021595200523734093,
0.0014358347980305552,
-0.011861979961395264,
0.013941517099738121,
-0.005300360731780529,
-0.009037991985678673,
-0.005586450919508934,
0.006583152338862419,
-0.022038180381059647,
-0.0065400851890444756,
0.049761250615119934,
-0.005472630262374878,
-0.03642267733812332,
0.06004819646477699,
0.012163450941443443,
-0.020044775679707527,
-0.001354314386844635,
0.01309247501194477,
-0.003282347461208701,
-0.002121067140251398,
-0.006780032068490982,
0.025163639336824417,
0.0009651701548136771,
0.01565190590918064,
-0.00662006763741374,
0.02189052104949951,
-0.005857159849256277,
-0.041443098336458206,
0.0017565326998010278,
0.004039102233946323,
0.030097927898168564,
0.024942150339484215,
-0.02397005818784237,
-0.0041929143480956554,
-0.010028541088104248,
-0.004466699901968241,
0.025274382904171944,
0.014273751527071,
-0.010625331662595272,
0.04993351921439171,
0.024449951946735382,
0.013424709439277649,
-0.01493821945041418,
-0.017017757520079613,
0.0069092339836061,
-0.04555295407772064,
-0.042329054325819016,
-0.042033735662698746,
0.011812759563326836,
-0.022124314680695534,
-0.027292396873235703,
-0.0061124879866838455,
-0.012563361786305904,
-0.02281339280307293,
-0.03044246695935726,
-0.011086767539381981,
-0.009222566150128841,
-0.0074137370102107525,
-0.025545092299580574,
-0.04626664146780968,
-0.033444877713918686,
-0.010963717475533485,
0.04670961946249008,
-0.00492813577875495,
0.0006775417714379728,
0.0037653171457350254,
0.003633038839325309,
0.027809204533696175,
-0.0021118384320288897,
-0.005697195418179035,
-0.032632749527692795,
-0.018629705533385277,
-0.0025763504672795534,
-0.009782441891729832,
-0.03644728660583496,
-0.02085690386593342,
0.008927247487008572,
-0.027440056204795837,
-0.01353545393794775,
0.01071146596223116,
-0.013461624272167683,
0.02825218439102173,
-0.0011366704711690545,
-0.0038452993612736464,
-0.02136140689253807,
-0.015319672413170338,
0.011437458917498589,
0.008748824708163738,
-0.04737408831715584,
0.016390204429626465,
-0.012360330671072006,
0.005297284573316574,
0.014913609251379967,
-0.03231281787157059,
-0.01968793198466301,
0.021250663325190544,
0.013695417903363705,
0.02138601616024971,
0.0013604669366031885,
0.03314955532550812,
-0.015356587246060371,
-0.023871619254350662,
0.029482679441571236,
0.00854579359292984,
0.007026130799204111,
-0.026283390820026398,
0.026283390820026398,
0.0009267171262763441,
-0.0031992890872061253,
0.011941961944103241,
0.02336711436510086,
0.03132842481136322,
-0.024622220546007156,
0.00770905613899231,
-0.019257258623838425,
0.028645941987633705,
-0.03076239489018917,
-0.021435236558318138,
-0.007278382778167725,
0.012514142319560051,
-0.021730555221438408,
-0.007038435898721218,
-0.030959274619817734,
0.032362040132284164,
0.001711927237920463,
-0.010170048102736473,
-0.019761761650443077,
0.0007256079697981477,
-0.022604208439588547,
-0.024905234575271606,
0.004171380773186684,
0.049785859882831573,
0.0059709809720516205,
-0.004543605726212263,
0.046906501054763794,
-0.02193973958492279,
0.03110693395137787,
0.013707723468542099,
0.02337942086160183,
-0.00913027860224247,
-0.038096148520708084,
0.005032727960497141,
0.0021349103190004826,
-0.00041260060970671475,
0.014876694418489933,
0.0227641724050045,
-0.002117990981787443,
-0.0021841300185769796,
0.026972467079758644,
0.004315963946282864,
-0.03642267733812332,
-0.015738042071461678,
0.007899782620370388,
-0.0007905935635790229,
0.012760241515934467,
0.004248286597430706,
-0.004672807641327381,
0.00839198101311922,
-0.04095090180635452,
0.016402509063482285,
-0.0037160972133278847,
-0.009142584167420864,
0.016193324699997902,
-0.02734161727130413,
-0.022395024076104164,
-0.01599644497036934,
-0.020906124264001846,
-0.053206637501716614,
0.02361321449279785,
0.004297506529837847,
-0.021582895889878273,
-0.0021733632311224937,
-0.018358998000621796,
-0.0205000601708889,
0.03135303407907486,
-0.049441322684288025,
-0.003442311892285943,
0.024856016039848328,
0.017214635387063026,
0.021287577226758003,
0.013916907832026482,
0.018039068207144737,
0.008804197423160076,
-0.022431937977671623,
0.015196623280644417,
-0.01941722445189953,
0.003534599207341671,
0.024154633283615112,
-0.022431937977671623,
0.011542050167918205,
0.03159913048148155,
-0.00235332315787673,
0.009948558174073696,
-0.00970245897769928,
-0.030885444954037666,
0.05192692205309868,
-0.021742861717939377,
-0.009628629311919212,
-0.020598499104380608,
-0.02987643890082836,
-0.01570112630724907,
0.004891220945864916,
0.02107839286327362,
0.006964606232941151,
0.010772990994155407,
0.0000767137244110927,
0.016943927854299545,
-0.006669287104159594,
-0.01069916132837534,
0.022973356768488884,
0.00853964127600193,
0.00884726457297802,
-0.008914941921830177,
0.028276793658733368,
0.009450207464396954,
-0.04641430079936981,
0.005149624776095152,
-0.015258148312568665,
-0.013400099240243435,
-0.018420523032546043,
-0.000024057153495959938,
-0.0020272417459636927,
0.0072968401946127415,
0.0017226941417902708,
0.0075798542238771915,
-0.020893817767500877,
-0.022579597309231758,
-0.00400218740105629,
0.02596346102654934,
0.010434604249894619,
-0.011160597205162048,
-0.0031008494552224874,
-0.031180763617157936,
0.00484507717192173,
-0.020167825743556023,
0.026972467079758644,
0.003962196409702301,
0.00799822248518467,
0.009339462965726852,
0.008902637287974358,
-0.029408849775791168,
0.02484370954334736,
-0.03506913036108017,
0.016968537122011185,
-0.041172388941049576,
-0.020647719502449036,
-0.04570061340928078,
0.043731819838285446,
-0.008139729499816895,
-0.016094885766506195,
-0.052320681512355804,
-0.005091176368296146,
0.012261890806257725,
-0.031008495017886162,
0.009296395815908909,
0.039154376834630966,
-0.005214225966483355,
0.02739083580672741,
-0.06339514255523682,
-0.011080614291131496,
-0.030122537165880203,
0.029285799711942673,
0.02137371152639389,
-0.0231087114661932,
-0.0013681575655937195,
-0.027317006140947342,
0.026160340756177902,
-0.00968400202691555,
-0.01827286183834076,
0.011738929897546768,
-0.040630970150232315,
-0.0022256593219935894,
0.0029716473072767258,
-0.018026763573288918,
-0.008533488027751446,
0.0031992890872061253,
-0.02398236282169819,
-0.0031269975006580353,
0.005718729458749294,
0.0031685265712440014,
0.026406439021229744,
0.032066721469163895,
-0.028301402926445007,
0.014630595222115517,
0.04503614455461502,
0.007229162845760584,
0.015762651339173317,
0.023810094222426414,
0.03595508635044098,
-0.008145881816744804,
-0.002205663826316595,
0.00512809120118618,
0.013190914876759052,
-0.03337104618549347,
0.02512672357261181,
-0.01195426657795906,
0.0037037923466414213,
0.012464922852814198,
-0.054043374955654144,
0.002862440887838602,
-0.022456549108028412,
0.018051372841000557,
0.022985661402344704,
0.01623024046421051,
-0.02198895998299122,
0.015381197445094585,
0.019601797685027122,
-0.026677148416638374,
0.010902192443609238,
-0.017571480944752693,
-0.025139030069112778,
0.04700493812561035,
-0.006780032068490982,
0.013658503070473671,
-0.007130722980946302,
0.053206637501716614,
-0.0052111498080194,
0.026111120358109474,
0.01910959929227829,
0.0033654060680419207,
0.0019226496806368232,
-0.017583785578608513,
0.008072052150964737,
0.011775844730436802,
0.02682480774819851,
0.0020456991624087095,
0.018949635326862335,
0.00799822248518467,
-0.022874917834997177,
0.01570112630724907,
-0.03231281787157059,
0.031525302678346634,
-0.015208927914500237,
-0.02051236480474472,
0.09440363943576813,
-0.016660913825035095,
-0.017460735514760017,
0.010680703446269035,
0.02478218451142311,
-0.023256370797753334,
-0.009628629311919212,
0.0027378532104194164,
0.019171124324202538,
-0.005238835699856281,
0.01738690584897995,
-0.0004675883974414319,
0.02931041084229946,
0.012311110273003578,
0.02682480774819851,
-0.020684635266661644,
0.01111752912402153,
0.032657358795404434,
0.015541162341833115,
-0.0007098422502167523,
-0.010446908883750439,
-0.009444055147469044,
-0.030393246561288834,
0.005251140799373388,
-0.01935569941997528,
-0.026037290692329407,
-0.007776733487844467,
-0.01411378663033247,
0.007807496003806591,
0.0036514962557703257,
0.017263855785131454,
-0.00867499504238367,
-0.010360774584114552,
-0.008638080209493637,
0.0014996667159721255,
-0.019897116348147392,
-0.01411378663033247,
-0.021804384887218475,
0.002230273559689522,
0.012391092255711555,
0.004537453409284353,
-0.005804863758385181,
-0.001431220443919301,
0.016648607328534126,
0.044297847896814346,
-0.011886589229106903,
-0.028596721589565277,
-0.0005225762142799795,
-0.006755421869456768,
-0.03073778562247753,
0.029753388836979866,
-0.004703570157289505,
0.015307367779314518,
-0.003617657581344247,
-0.026578709483146667,
-0.011369781568646431,
0.011326713487505913,
0.023010270670056343,
-0.013941517099738121,
-0.0410001203417778,
-0.018457436934113503,
0.032362040132284164,
0.036619555205106735,
0.005860236473381519,
-0.0012720250524580479
] | 2025-01-01 | 1 | 39739533 | [
"tonic CARs",
"CAR quality",
"CARs",
"tonic",
"Chimeric antigen receptors",
"expansion",
"tonic CAR T cell proliferation",
"synthetic molecules",
"flow cytometry",
"quality",
"complete details",
"dasatinib",
"execution",
"T cell transduction",
"retrovirus",
"verification",
"an intracellular signaling domain",
"steps",
"an extracellular antigen-binding domain",
"(FDA)-approved kinase inhibitor",
"Caulier et al",
"assay",
"a Food and Drug Administration",
"the expansion",
"a protocol",
"this protocol",
"the use",
"only 30 nM",
"We"
] | [
"cancer",
"cell culture",
"health sciences",
"immunology"
] | 0 | 10.1016/j.xpro.2024.103529 | [
"Rosselle",
"Leray",
"Joaquina",
"Caulier",
"McCormack",
"Gelebart",
"Wälchli",
"Inderberg"
] | [
"Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway. Electronic address: [email protected].",
"Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway; Medical Faculty, University of Oslo, Oslo, Norway.",
"Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway; Medical Faculty, University of Oslo, Oslo, Norway.",
"Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway; Institute for Cancer Research, Department of Molecular Cell Biology, Oslo University Hospital, Oslo, Norway; Center for Cancer Cell Reprogramming (CanCell), Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.",
"Department of Clinical Science, Precision Oncology Research Group, University of Bergen, 5021 Bergen, Norway; Centre for Pharmacy, Department of Clinical Science, University of Bergen, Bergen, Norway; Centre for Cancer Biomarkers (CCBIO), University of Bergen, Bergen, Norway.",
"Department of Clinical Science, Precision Oncology Research Group, University of Bergen, 5021 Bergen, Norway; Centre for Cancer Biomarkers (CCBIO), University of Bergen, Bergen, Norway.",
"Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway.",
"Translational Research Unit, Section for Cellular Therapy, Department of Oncology, Oslo University Hospital, Oslo, Norway. Electronic address: [email protected]."
] | [
"39739533"
] | [] | 8.574634 | 4.567834 |
39737899 | 90 | PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial. | Here we report results of a phase 1 multi-institutional, open-label, dose-escalation trial (NCT02744287) of BPX-601, an investigational autologous PSCA-directed GoCAR-T® cell product containing an inducible MyD88/CD40 ON-switch responsive to the activating dimerizer rimiducid, in patients with metastatic pancreatic (mPDAC) or castration-resistant prostate cancer (mCRPC). Primary objectives were to evaluate safety and tolerability and determine the recommended phase 2 dose/schedule (RP2D). Secondary objectives included the assessment of efficacy and characterization of the pharmacokinetics of rimiducid. Thirty-three patients received BPX-601 with or without rimiducid, 24 patients with mPDAC and 9 with mCRPC. Two dose-limiting toxicities and two treatment-related deaths occurred in the highest-dose mCRPC cohort, after which the study was terminated, without determination of the RP2D. Two mCRPC patients experienced partial responses (one unconfirmed), and 56% of mCRPC patients achieved ≥50% reduction in prostate-specific antigen. BPX-601 cell expansion, long-term persistence in peripheral blood, and tumor infiltration were observed. Rimiducid increased circulating inflammatory cytokines/chemokines consistent with GoCAR-T® cell activation. These results suggest that pharmacological activation of GoCAR-T® cells is feasible and may offer a promising avenue to control chimeric antigen receptor-T cell activity with continued dose-optimization to improve tolerability. | [
0.00678769638761878,
0.0034950627014040947,
0.049595098942518234,
0.07186228781938553,
-0.045040447264909744,
-0.025809694081544876,
0.011823116801679134,
0.03595644608139992,
0.05268213897943497,
-0.04612850025296211,
-0.002424403093755245,
-0.01648530922830105,
-0.03423579782247543,
0.003463433124125004,
0.049417972564697266,
-0.02593621239066124,
0.053238820284605026,
0.00631957920268178,
-0.014752010814845562,
0.03413458541035652,
0.02214066870510578,
0.015333994291722775,
-0.02621455118060112,
0.0015830578049644828,
-0.05622464790940285,
-0.010178381577134132,
0.01637144200503826,
-0.02957993373274803,
0.018889153376221657,
-0.024114351719617844,
0.010735061019659042,
-0.021267693489789963,
-0.04015684872865677,
0.00045190684613771737,
-0.04759611189365387,
-0.03076920285820961,
0.04850704222917557,
0.03608296439051628,
-0.022520223632454872,
-0.029959486797451973,
-0.00010922070941887796,
-0.02649289183318615,
0.013765170238912106,
0.07464568316936493,
-0.07206471264362335,
-0.003956853877753019,
-0.004168771672993898,
-0.036867376416921616,
0.055263109505176544,
-0.01404350996017456,
-0.040662918239831924,
0.023734796792268753,
-0.009292755275964737,
0.06715580821037292,
-0.034817781299352646,
0.030414951965212822,
-0.015865370631217957,
0.010026560164988041,
0.00624050572514534,
0.0010825205827131867,
0.01585271954536438,
-0.027884591370821,
0.03861332684755325,
-0.03469126299023628,
-0.04582485929131508,
-0.00472861435264349,
-0.027201393619179726,
0.03372972831130028,
0.001408304669894278,
0.01742154359817505,
0.011772509664297104,
0.008267958648502827,
-0.00009572874114383012,
0.01403085794299841,
0.045875463634729385,
0.027884591370821,
0.026341069489717484,
0.045141659677028656,
-0.016523264348506927,
-0.009710264392197132,
0.04025806114077568,
0.010747713036835194,
0.010108796879649162,
-0.059817761182785034,
-0.021988846361637115,
-0.018990367650985718,
0.008236329071223736,
-0.03271758183836937,
-0.020521236583590508,
0.024671031162142754,
-0.03347669169306755,
-0.0218370258808136,
-0.04053639993071556,
0.052378494292497635,
-0.009052370674908161,
-0.02062245085835457,
-0.02892203815281391,
-0.00576289976015687,
0.05602221563458443,
0.04787445068359375,
0.040005024522542953,
-0.007369679864495993,
-0.01856020651757717,
-0.01305666845291853,
0.023861315101385117,
0.005218871869146824,
-0.01648530922830105,
0.025227710604667664,
0.04731777310371399,
-0.009937996976077557,
0.05086027830839157,
0.010077167302370071,
0.0050828647799789906,
0.07408900558948517,
-0.007407634984701872,
-0.03390685096383095,
-0.023760100826621056,
-0.016599174588918686,
-0.04164975881576538,
0.01686486415565014,
-0.01748480275273323,
0.04288963973522186,
0.007002776954323053,
-0.028036411851644516,
-0.014625493437051773,
-0.019597655162215233,
0.056680113077163696,
-0.03669025003910065,
-0.0071482728235423565,
-0.04023275896906853,
-0.030010094866156578,
-0.00014687961083836854,
0.050531331449747086,
-0.025872953236103058,
-0.062246907502412796,
0.02677123062312603,
-0.00734437583014369,
-0.012335515581071377,
-0.017927614971995354,
-0.04084004461765289,
0.02138156071305275,
-0.00702175498008728,
0.005184079520404339,
0.029073860496282578,
-0.06568820029497147,
-0.05556675046682358,
-0.011924331076443195,
0.012177367694675922,
-0.025493398308753967,
-0.006465075071901083,
-0.06027322635054588,
0.03403336927294731,
0.056275252252817154,
-0.004864620976150036,
0.0348430871963501,
-0.052378494292497635,
-0.022963035851716995,
0.09058696031570435,
-0.016358790919184685,
-0.018749983981251717,
-0.01251896657049656,
0.01957235112786293,
-0.00252561760134995,
-0.04220644012093544,
0.02506323717534542,
0.011715576983988285,
0.00702175498008728,
-0.006386001594364643,
-0.06032383441925049,
-0.0014075139770284295,
-0.0034286407753825188,
-0.03335017338395119,
-0.10106266289949417,
-0.03605765849351883,
-0.04091595485806465,
-0.012835261411964893,
-0.024291476234793663,
0.026923052966594696,
-0.052378494292497635,
-0.03856271877884865,
-0.0016526427352800965,
-0.006629548966884613,
0.0705971047282219,
-0.015005047433078289,
-0.021874981001019478,
0.004772895481437445,
-0.012158390134572983,
0.054149750620126724,
-0.036209482699632645,
-0.008097158744931221,
0.08881571143865585,
0.020280852913856506,
0.012955454178154469,
0.0028703794814646244,
-0.019547047093510628,
-0.035652801394462585,
0.02937750332057476,
0.046330928802490234,
-0.0292762890458107,
-0.011715576983988285,
0.008982785977423191,
-0.007066036108881235,
0.015688244253396988,
0.02937750332057476,
-0.016497960314154625,
-0.02408904768526554,
0.01011512242257595,
0.016573872417211533,
0.015232780016958714,
0.0009085581405088305,
0.04916493594646454,
-0.010855253785848618,
-0.02072366513311863,
0.05232788994908333,
0.001636827946640551,
-0.033805638551712036,
0.01515686884522438,
0.04706473648548126,
0.06563759595155716,
-0.020913442596793175,
-0.0012264348333701491,
-0.015789460390806198,
0.004624236840754747,
0.014347152784466743,
-0.01742154359817505,
0.022128017619252205,
0.0160298440605402,
-0.008426105603575706,
0.010994423180818558,
0.004820339847356081,
0.0017680905293673277,
0.018990367650985718,
-0.02173580974340439,
0.005595263093709946,
-0.005804018117487431,
0.010412439703941345,
0.04572364315390587,
-0.020040467381477356,
0.05521250143647194,
-0.04567303508520126,
0.00905869621783495,
0.013284401036798954,
-0.013588044792413712,
-0.07859304547309875,
0.015245432034134865,
-0.020571844652295113,
0.009792501106858253,
-0.07591086626052856,
0.008691794238984585,
-0.009153584949672222,
-0.008261632174253464,
-0.01399290282279253,
-0.007015428971499205,
-0.012537944130599499,
-0.006673830095678568,
0.007110317703336477,
0.016055148094892502,
-0.028517181053757668,
-0.02704957127571106,
-0.026442283764481544,
0.012847913429141045,
-0.0036595361307263374,
-0.047545503824949265,
-0.042332958430051804,
-0.027403822168707848,
0.010039212182164192,
0.004497718531638384,
0.0020796414464712143,
-0.0022630926687270403,
-0.012772003188729286,
0.006205712910741568,
-0.00900176353752613,
0.03390685096383095,
0.01939522475004196,
-0.05273274704813957,
0.03663964197039604,
0.04620441049337387,
0.034539442509412766,
-0.06239873170852661,
0.01449897512793541,
0.032489851117134094,
-0.00994432345032692,
0.002097037620842457,
-0.020420022308826447,
-0.009362339973449707,
-0.001483424799516797,
0.03744935989379883,
0.017269721254706383,
-0.008400802500545979,
-0.01887650229036808,
0.0000012633278174689622,
0.014701403677463531,
0.010475698858499527,
-0.027909893542528152,
0.016750996932387352,
-0.04825400561094284,
-0.015738852322101593,
-0.04678639397025108,
0.015346646308898926,
0.04294024407863617,
0.0169660784304142,
0.028238840401172638,
0.00774290831759572,
-0.05728739872574806,
0.009349687956273556,
0.02808701992034912,
0.015549074858427048,
-0.026897748932242393,
-0.03289470821619034,
0.02722669579088688,
0.0054592564702034,
-0.03423579782247543,
-0.009634354151785374,
-0.003931550309062004,
0.012854239903390408,
0.007230509538203478,
0.034615352749824524,
-0.0056585222482681274,
-0.023899270221590996,
-0.016105754300951958,
-0.023836011067032814,
0.0029636865947395563,
-0.023102205246686935,
-0.022583482787013054,
-0.004440785385668278,
-0.02806171588599682,
0.0001085288095055148,
-0.00399797223508358,
0.038081951439380646,
0.002087548840790987,
-0.00312974164262414,
-0.024898763746023178,
0.029681148007512093,
0.014941788278520107,
0.01585271954536438,
-0.0111588966101408,
-0.010374484583735466,
-0.04005563259124756,
0.013233793899416924,
0.009374991990625858,
-0.025961514562368393,
0.012753024697303772,
-0.03271758183836937,
-0.006376512348651886,
0.00803389959037304,
0.008894222788512707,
0.00425100838765502,
0.020875487476587296,
0.01637144200503826,
-0.00157515041064471,
-0.0027944687753915787,
0.009248473681509495,
0.0026125989388674498,
-0.005297945812344551,
0.004817177075892687,
-0.01352478563785553,
-0.007685975171625614,
-0.021786417812108994,
0.0018851198256015778,
-0.0012232719454914331,
-0.016599174588918686,
0.008862593211233616,
-0.04572364315390587,
0.022621437907218933,
0.02589825540781021,
0.03243924304842949,
-0.04139672592282295,
0.006404979154467583,
-0.05227728188037872,
-0.028036411851644516,
-0.0005151659133844078,
0.005006954073905945,
0.004152956884354353,
0.012727721594274044,
-0.006142454221844673,
0.05996958166360855,
-0.008615883067250252,
0.04752020165324211,
0.008723423816263676,
-0.0007029662374407053,
0.05587039515376091,
0.014903833158314228,
-0.013031365349888802,
-0.016852211207151413,
0.010323877446353436,
0.02082487940788269,
0.06351208686828613,
0.004307941533625126,
-0.06007079780101776,
0.006439771503210068,
0.010633846744894981,
-0.011386629194021225,
-0.0008018084918148816,
-0.05662950500845909,
-0.05587039515376091,
0.041143689304590225,
0.011190526187419891,
0.04951918497681618,
0.05384610593318939,
0.033501993864774704,
-0.030996935442090034,
-0.045242875814437866,
-0.024392690509557724,
-0.02016698569059372,
-0.014410411939024925,
-0.025468094274401665,
0.02249491959810257,
-0.01714320294559002,
-0.00011406397970858961,
-0.034918997436761856,
0.0020859672222286463,
0.005940025206655264,
0.03522264212369919,
0.01060221716761589,
0.040106240659952164,
-0.0066042449325323105,
-0.028694305568933487,
0.02593621239066124,
-0.016244925558567047,
0.06255055218935013,
0.06842099130153656,
0.011222155764698982,
0.016333486884832382,
-0.026467587798833847,
0.005424463655799627,
0.012790980748832226,
0.0017364609520882368,
-0.01710524782538414,
0.009482531808316708,
-0.022861821576952934,
0.011013400740921497,
0.04665987566113472,
0.022760607302188873,
-0.026341069489717484,
-0.01006451528519392,
0.04812748730182648,
-0.039574865251779556,
0.012379796244204044,
-0.07079952955245972,
0.02124238945543766,
0.014258590526878834,
-0.01310727559030056,
-0.021925587207078934,
-0.03757587820291519,
0.0008966970490291715,
-0.004820339847356081,
0.04777323827147484,
0.031654831022024155,
-0.0376264862716198,
0.0042035640217363834,
-0.00425100838765502,
-0.01974947564303875,
0.0023548181634396315,
0.03299592062830925,
-0.036943286657333374,
-0.037778306752443314,
0.032489851117134094,
-0.0622975155711174,
-0.010399788618087769,
0.03365381807088852,
0.0715586394071579,
-0.007009102962911129,
0.009773523546755314,
-0.032869402319192886,
-0.017307676374912262,
0.02854248508810997,
0.00997595302760601,
0.005949513986706734,
0.00041671900544315577,
-0.05278335511684418,
-0.0014865878038108349,
0.012892195023596287,
-0.016700390726327896,
-0.0015522190369665623,
-0.015637638047337532,
-0.0005630055675283074,
0.007939010858535767,
-0.027631554752588272,
-0.020609799772500992,
0.07889669388532639,
0.013638651929795742,
-0.03701919689774513,
0.01496709231287241,
0.0058356476947665215,
0.023772751912474632,
0.0799088329076767,
-0.024190261960029602,
0.03803134337067604,
-0.0343623161315918,
0.01915484108030796,
-0.021508077159523964,
0.005977980326861143,
-0.031477704644203186,
-0.014018205925822258,
-0.0024196587037295103,
-0.014423063956201077,
0.05607282370328903,
0.0012327608419582248,
-0.02422821708023548,
0.03542507067322731,
0.003460270119830966,
0.058805614709854126,
-0.002492406638339162,
0.0005131890648044646,
0.026568802073597908,
0.05012647435069084,
-0.0030063865706324577,
0.04223174229264259,
-0.022570829838514328,
0.02947871945798397,
-0.02412700280547142,
0.0010477281175553799,
0.0021286671981215477,
-0.024797549471259117,
-0.025354228913784027,
0.0028276797384023666,
-0.025227710604667664,
-0.025455443188548088,
0.005841973703354597,
0.00448506698012352,
-0.007458242122083902,
0.0077682118862867355,
0.007869426161050797,
0.031022239476442337,
-0.009115629829466343,
-0.0390687920153141,
-0.028846127912402153,
-0.07211531698703766,
-0.046153806149959564,
-0.02044532634317875,
0.006635874509811401,
0.005269479006528854,
0.017307676374912262,
0.03562749922275543,
-0.020015165209770203,
-0.0171811580657959,
-0.015561726875603199,
-0.004953183699399233,
-0.0033147744834423065,
0.006167757790535688,
0.002089130226522684,
-0.027935197576880455,
0.016460005193948746,
-0.014941788278520107,
0.02148277498781681,
0.0030237827450037003,
0.037879519164562225,
-0.00047207067837007344,
0.0110387047752738,
0.006661178078502417,
0.01496709231287241,
-0.011430910788476467,
0.012911172583699226,
0.012993409298360348,
0.042712513357400894,
0.00999493058770895,
-0.026442283764481544,
-0.06163962185382843,
0.027479732409119606,
-0.011064008809626102,
0.005348552949726582,
0.01752275787293911,
0.015789460390806198,
-0.041497938334941864,
-0.013765170238912106,
0.009501509368419647,
-0.0010651242919266224,
-0.04008093476295471,
-0.043927084654569626,
0.00799594447016716,
-0.009337035939097404,
0.015182172879576683,
0.004197238013148308,
-0.030263131484389305,
0.05754043534398079,
0.02384866215288639,
-0.02631576545536518,
-0.017927614971995354,
-0.010576914064586163,
-0.0018914457177743316,
-0.023798055946826935,
-0.017611321061849594,
0.04665987566113472,
0.050708457827568054,
-0.007882078178226948,
0.004874110221862793,
-0.01953439600765705,
0.0056806630454957485,
0.03130057826638222,
0.048000968992710114,
-0.023026295006275177,
-0.03142709657549858,
0.043269190937280655,
-0.003669025143608451,
-0.014207983389496803,
-0.0010453558061271906,
0.06928131729364395,
-0.012392448261380196,
-0.023911921307444572,
0.02062245085835457,
0.012740373611450195,
-0.014739359728991985,
-0.0019910787232220173,
-0.02047063037753105,
-0.02454451285302639,
0.03542507067322731,
-0.004817177075892687,
-0.019407877698540688,
0.019496440887451172,
0.013360312208533287,
0.029706452041864395,
0.03504551574587822,
-0.012544270604848862,
0.019774779677391052,
0.010962793603539467,
0.006218364927917719,
-0.027859287336468697,
-0.027555642649531364,
0.0413714200258255,
-0.029453415423631668,
0.025088541209697723,
-0.011051356792449951,
0.017674580216407776,
0.00799594447016716,
-0.008577927947044373,
-0.0478491485118866,
-0.02722669579088688,
-0.015460512600839138,
0.025645220652222633,
0.02269734814763069,
0.018901804462075233,
-0.013094623573124409,
-0.0162702277302742,
0.04982282966375351,
0.0056933145970106125,
-0.015296039171516895,
0.03097163327038288,
0.009520487859845161,
-0.017459498718380928,
-0.01305666845291853,
-0.005231523886322975,
0.02742912620306015,
0.007464568130671978,
-0.041219599545001984,
0.02245696447789669,
-0.028593091294169426,
-0.01692812331020832,
-0.013372964225709438,
-0.0033432410564273596,
-0.03142709657549858,
0.0036247437819838524,
-0.0025572471786290407,
-0.014144724234938622,
0.010697105899453163,
0.017573364078998566,
-0.03717102110385895,
-0.0008057621889747679,
0.013727214187383652,
0.02687244489789009,
0.07100196182727814,
-0.03653842955827713,
0.04592607170343399,
-0.022153319790959358,
0.0021460633724927902,
-0.027378518134355545,
0.01107033435255289,
-0.02173580974340439,
0.014018205925822258,
0.021432166919112206,
0.016915470361709595,
0.09473675489425659,
-0.002127085579559207,
0.008400802500545979,
0.01050100289285183,
0.0035741364117711782,
0.013701911084353924,
0.01046304777264595,
0.015409905463457108,
-0.013841080479323864,
0.023798055946826935,
0.0011236389400437474,
-0.0018360939575359225,
-0.054807644337415695,
-0.03800603747367859,
-0.012088805437088013,
-0.0010603799019008875,
-0.0037702396512031555,
-0.007103991694748402,
0.005389671307057142,
-0.014764662832021713,
-0.011797813698649406,
-0.007458242122083902,
0.0019515417516231537,
-0.033881548792123795,
0.023899270221590996,
-0.013006061315536499,
-0.0012722976971417665,
-0.01758601702749729,
0.008236329071223736,
-0.012265929952263832,
0.02259613387286663,
-0.0011441981187090278,
0.04617910832166672,
-0.018155347555875778,
-0.00950783584266901,
-0.036487821489572525,
0.0035931142047047615,
-0.016080452129244804,
0.005544655956327915,
0.01159538421779871,
0.008248980157077312,
-0.010735061019659042,
-0.032869402319192886,
-0.007496197707951069,
-0.010785668157041073,
0.005756573751568794,
-0.023102205246686935,
0.023494413122534752,
-0.007451916579157114,
-0.00006523590127471834,
0.02420291304588318,
0.030414951965212822,
-0.0007088967831805348,
0.0022583482787013054,
0.03717102110385895,
0.03031373769044876,
-0.005851462483406067,
0.0576416477560997,
-0.005433952435851097,
0.015511119738221169,
0.010886883363127708,
-0.021685203537344933,
-0.030541470274329185,
-0.01647265814244747,
-0.02854248508810997,
-0.0006314044003374875,
-0.018243910744786263,
0.0055573079735040665,
-0.003909409511834383,
0.003966342657804489,
-0.005889418069273233,
0.0030680641066282988,
-0.0595141164958477,
0.0010121448431164026,
-0.03013661317527294,
0.0031281602568924427,
0.05728739872574806,
-0.001880375319160521,
-0.031654831022024155,
-0.03868923708796501,
0.0013537437189370394,
0.009868412278592587,
-0.02742912620306015,
0.007116643246263266,
0.023734796792268753,
-0.01260120328515768,
-0.0035962772089987993,
0.021406862884759903,
-0.021394211798906326,
-0.02750503644347191,
0.029124468564987183,
0.006907888688147068,
-0.005864114034920931,
-0.00005233698175288737,
-0.017054641619324684,
0.02082487940788269,
0.0292762890458107,
-0.010614869184792042,
0.011848420836031437,
0.04023275896906853,
-0.013170534744858742,
0.010412439703941345,
-0.0034159887582063675,
-0.013347660191357136,
0.02436738647520542,
0.015688244253396988,
-0.05227728188037872,
-0.010342855006456375,
0.006882585119456053,
0.013499481603503227,
-0.03734814375638962,
0.008723423816263676,
-0.0020116379018872976,
0.039549559354782104,
-0.01018470712006092,
-0.04321858659386635,
0.0001623978459974751,
0.011563754640519619,
-0.0028324241284281015,
-0.004383852239698172,
-0.016346139833331108,
0.0311487577855587,
-0.05511128529906273,
0.03641191124916077,
0.0090713482350111,
0.0111588966101408,
0.02370949275791645,
-0.09645740687847137,
-0.002943127416074276,
-0.013183186762034893,
0.010652824304997921,
-0.037778306752443314,
0.003956853877753019,
-0.0033811964094638824,
-0.010450395755469799,
-0.0021413189824670553,
-0.011260111816227436,
0.024936718866229057,
-0.012721395120024681,
0.007711278740316629,
-0.014207983389496803,
-0.004804525058716536,
-0.008546298369765282,
-0.01728237420320511,
-0.05131574347615242,
0.03512142598628998,
0.01992660202085972,
-0.020103726536035538,
0.03312243893742561,
-0.0010437744203954935,
0.04994934797286987,
-0.014233286492526531,
-0.006572615820914507,
-0.001466819318011403,
-0.0009512579999864101,
-0.01672569289803505,
-0.022747956216335297,
0.026062730699777603,
0.0035077144857496023,
-0.005089190788567066,
0.004709636326879263,
-0.019635610282421112,
-0.015536423772573471,
-0.010393462143838406,
-0.02864369936287403,
-0.00016605501878075302,
0.019104234874248505,
0.0059463512152433395,
0.009552117437124252,
0.014347152784466743,
-0.0021033636294305325,
0.0036785139236599207,
0.00406755693256855,
-0.012923824600875378,
0.012000242248177528,
0.01877528615295887,
-0.02332993783056736,
-0.013714563101530075,
-0.00047958269715309143,
-0.02513914741575718,
0.0007077106274664402,
-0.019635610282421112,
-0.006167757790535688,
-0.010292247869074345,
0.021090568974614143,
0.0046463776379823685,
-0.003514040494337678,
-0.009223169647157192,
0.045774251222610474,
0.021508077159523964,
0.0024338921066373587,
-0.013676607050001621,
-0.006212038919329643,
-0.03539976477622986,
0.026619410142302513,
-0.03279349207878113,
-0.0007326189079321921,
-0.02621455118060112,
0.017307676374912262,
-0.017370935529470444,
0.007470894139260054,
-0.02357032336294651,
-0.008957481943070889,
0.0023168628104031086,
-0.006120313424617052,
0.006186735350638628,
0.010678128339350224,
-0.007198880426585674,
-0.04268720746040344,
0.009286428801715374,
0.0024623586796224117,
-0.024949369952082634,
0.009988604113459587,
0.010867904871702194,
0.008426105603575706,
0.023481760174036026,
-0.005886254832148552,
0.006812999956309795,
-0.03985320404171944,
-0.030161917209625244,
0.01648530922830105,
-0.026821838691830635,
-0.018383080139756203,
-0.020002512261271477,
-0.000982887577265501,
0.0011386629194021225,
0.009665983729064465,
0.016257576644420624,
-0.05607282370328903,
-0.0139422956854105,
-0.011215830221772194,
-0.024569816887378693,
-0.008419780060648918,
0.026163944974541664,
0.015270735137164593,
-0.018623465672135353,
-0.02669532038271427,
0.00224253349006176,
-0.006072869058698416,
-0.001137872226536274,
0.01348683051764965,
0.011418258771300316,
0.03570340946316719,
0.04053639993071556,
-0.015802111476659775,
-0.022241882979869843,
-0.006442934740334749,
0.04106777906417847,
0.012367145158350468,
0.0011702924966812134,
0.0008856267668306828,
-0.024278825148940086,
0.027277303859591484,
-0.004247845616191626,
0.019547047093510628,
-0.023684188723564148,
0.009811478666961193,
0.019357269629836082,
0.040865346789360046,
0.007357027847319841,
-0.02263408899307251,
0.00498165050521493,
0.04592607170343399,
0.04035927727818489,
0.026948357000947,
-0.0039600166492164135,
0.007616390008479357,
-0.007939010858535767,
0.0075910864397883415,
0.011361326090991497,
-0.0188132431358099,
0.029352201148867607,
0.01053263247013092,
-0.060931120067834854,
0.01361334789544344,
0.020673058927059174,
0.015169520862400532,
0.014916484244167805,
-0.008381824940443039,
0.014865877106785774,
0.017788445577025414,
-0.01060221716761589,
0.039827898144721985,
0.00401694979518652,
-0.008811986073851585,
-0.04053639993071556,
0.0025556657928973436,
0.0021935077384114265,
0.03069329261779785,
-0.04992404580116272,
-0.028011107817292213,
0.002337421989068389,
-0.04954449087381363,
-0.004734939895570278,
-0.006812999956309795,
-0.0026632060762494802,
0.0077808634378015995,
0.025986818596720695,
-0.01985068991780281,
0.012360818684101105,
-0.012556921690702438,
0.0009987022494897246,
-0.0027106504421681166,
0.0024070069193840027,
-0.015878021717071533,
0.0239498782902956,
0.03094632923603058,
-0.026062730699777603,
-0.009678634814918041,
0.0018123718909919262,
-0.028517181053757668,
0.026543498039245605,
-0.016194317489862442,
0.012904847040772438,
-0.028517181053757668,
0.035197336226701736,
0.004795036278665066,
0.011500495485961437,
0.01821860671043396,
0.020635103806853294,
0.03496960550546646,
0.025784390047192574,
0.01454958226531744,
0.018712026998400688,
0.043927084654569626,
-0.0450657494366169,
-0.027176089584827423,
-0.04154854640364647,
0.0520748533308506,
0.01505565457046032,
-0.012493662536144257,
-0.019825387746095657,
0.006278460845351219,
0.03848680853843689,
-0.0316295251250267,
-0.00010665081208571792,
0.041143689304590225,
0.0034349665511399508,
0.02259613387286663,
-0.022292491048574448,
-0.010247966274619102,
-0.01668773777782917,
-0.04622971639037132,
-0.009703938849270344,
0.03418519347906113,
-0.032312724739313126,
-0.031477704644203186,
-0.026265159249305725,
-0.04329449683427811,
-0.005386508535593748,
-0.017092596739530563,
-0.000620729464571923,
-0.011310718953609467,
0.00405806815251708,
0.02165989950299263,
-0.03142709657549858,
0.018471643328666687,
-0.002981082769110799,
0.0260374266654253,
-0.021634595468640327,
0.008179395459592342,
0.005886254832148552,
0.017257070168852806,
-0.025316273793578148,
-0.011772509664297104,
-0.0028608907014131546,
-0.028137626126408577,
0.05288456752896309,
0.008230002596974373,
-0.036867376416921616,
-0.0211411751806736,
-0.029453415423631668,
0.0017823238158598542,
0.02909916453063488,
-0.016713041812181473,
-0.029959486797451973,
-0.017914963886141777,
0.001994241727516055,
-0.018028829246759415,
0.017396239563822746,
0.01752275787293911,
0.03542507067322731,
0.018016178160905838,
0.022823866456747055,
-0.02482285164296627,
0.027833983302116394,
-0.00143835274502635,
-0.015827415511012077,
-0.010001256130635738,
0.0105705875903368,
-0.011367651633918285,
0.027074875310063362,
-0.022343097254633904,
-0.004687495995312929,
0.0017364609520882368,
0.03160422295331955,
0.029428111389279366,
0.023494413122534752,
-0.01985068991780281,
-0.03413458541035652,
-0.002762839198112488,
0.02669532038271427,
-0.0029494534246623516,
0.024531859904527664,
-0.015941280871629715,
-0.0030490863136947155,
-0.00002666270302142948,
-0.0016573872417211533,
0.026998963207006454,
-0.0034381295554339886,
0.015903325751423836,
-0.0084830392152071,
0.0049468581564724445,
-0.02778337523341179,
-0.03271758183836937,
0.008723423816263676,
-0.0026632060762494802,
-0.01008349284529686,
0.026062730699777603,
-0.008419780060648918,
0.03539976477622986,
-0.010703431442379951,
-0.01901567168533802,
0.0110387047752738,
-0.0054497672244906425,
0.008211025036871433,
-0.0048361546359956264,
-0.013739866204559803,
0.00388094293884933,
-0.04352222755551338,
-0.024139653891324997,
0.008628535084426403,
0.0032246301416307688,
-0.0202049408107996,
-0.032110296189785004,
0.020053120329976082,
-0.00964700523763895,
-0.05364367738366127,
-0.03646251931786537,
0.007363353855907917,
-0.02420291304588318,
0.02190028503537178,
0.03170543909072876,
-0.029681148007512093,
0.00680667394772172,
-0.004276311956346035,
0.007388657424598932,
-0.006183572579175234,
0.03038964979350567,
-0.009748220443725586,
0.012860565446317196,
-0.0029020090587437153,
0.01561233401298523,
0.0000034193246847280534,
0.002647391287609935,
-0.008242654614150524,
-0.0051714275032281876,
0.001696924096904695,
0.004652703180909157,
-0.02426617220044136,
-0.005949513986706734,
0.0017775794258341193,
0.028415966778993607,
0.024051092565059662,
0.010089819319546223,
-0.012930150143802166,
-0.020571844652295113,
-0.017573364078998566,
-0.003672187915071845,
0.001698505599051714,
0.010393462143838406,
0.032489851117134094,
-0.00962802767753601,
0.01672569289803505,
-0.020217593759298325,
0.00019195169443264604,
-0.03813255578279495,
0.05430157110095024,
0.01662447862327099,
0.008881570771336555,
0.023026295006275177,
-0.002327933209016919,
0.006800348404794931,
0.012607528828084469,
0.000446371705038473,
-0.00018720726075116545,
0.010728735476732254,
0.006477727089077234,
0.012772003188729286,
-0.0047697327099740505,
0.0064492602832615376,
-0.011418258771300316,
-0.003185093402862549,
-0.029250986874103546,
-0.019496440887451172,
0.007167250849306583,
0.021267693489789963,
0.018585510551929474,
0.018800590187311172,
0.01166496891528368,
-0.019635610282421112,
-0.03198377788066864,
0.011373978108167648,
0.028289448469877243,
-0.005263152997940779,
0.020609799772500992,
0.029529325664043427,
0.030895721167325974,
-0.016940774396061897,
0.01682690903544426,
-0.012936476618051529,
0.0012485755141824484,
-0.02343115396797657,
0.01006451528519392,
-0.0005246547516435385,
0.032591063529253006,
-0.050328902900218964,
0.0248608086258173,
0.00734437583014369,
0.018345125019550323,
-0.018016178160905838,
-0.025227710604667664,
-0.005443441681563854,
0.022343097254633904,
-0.004987976513803005,
-0.004159282892942429,
0.0162702277302742,
-0.005775551311671734,
0.02517710253596306,
0.0013015549629926682,
0.03367912024259567,
-0.005440278444439173,
0.0047823842614889145,
0.017636623233556747,
0.047090038657188416,
0.013221141882240772,
0.020748969167470932,
-0.012297559529542923,
0.018433688208460808,
-0.029858272522687912,
0.014878529123961926,
-0.0111588966101408,
-0.019825387746095657,
0.016042495146393776,
-0.04539469629526138,
-0.025986818596720695,
0.01640939898788929,
0.03879044950008392,
0.0012722976971417665,
-0.006009609904140234,
-0.021330952644348145,
-0.04154854640364647,
-0.0192940104752779,
0.005206219851970673,
0.009172562509775162,
-0.012772003188729286,
0.035652801394462585,
0.022381052374839783,
-0.016738345846533775,
-0.001571987522765994,
0.013081972487270832,
-0.049038417637348175,
0.010001256130635738,
-0.02937750332057476,
0.030086005106568336,
-0.04167506471276283,
0.03173074126243591,
0.01575150340795517,
-0.0021002006251364946,
0.025506049394607544,
0.029073860496282578,
-0.00001359081215923652,
-0.010266944766044617,
-0.02169785462319851,
-0.022722652181982994,
0.01936992257833481,
0.03223681449890137,
0.010450395755469799,
0.00704073254019022,
-0.040283363312482834,
0.002971593989059329,
-0.027277303859591484,
0.01362599991261959,
-0.004077046178281307,
-0.029782362282276154,
0.029149770736694336,
0.007610063999891281,
-0.018787939101457596,
0.014954440295696259,
-0.018370429053902626,
-0.01548581663519144,
0.007451916579157114,
-0.02402578853070736,
-0.0086032310500741,
0.025607265532016754,
-0.008634860627353191,
0.0239498782902956,
0.010172056034207344,
0.032312724739313126,
0.024190261960029602,
-0.016662433743476868,
0.011045030318200588,
-0.016561219468712807,
0.026163944974541664,
-0.004168771672993898,
0.011367651633918285,
0.017877008765935898,
-0.013119927607476711,
0.016637131571769714,
0.022887125611305237,
-0.008830963633954525,
0.03757587820291519,
0.025328924879431725,
-0.01595393382012844,
-0.03744935989379883,
0.055263109505176544,
-0.019496440887451172,
-0.01301871333271265,
-0.008211025036871433,
0.006072869058698416,
-0.0043806894682347775,
-0.02704957127571106,
-0.01692812331020832,
-0.013271749019622803,
-0.015169520862400532,
-0.02036941424012184,
0.03142709657549858,
-0.03886636346578598,
-0.008913200348615646,
-0.001500030281022191,
-0.00014035603089723736,
-0.007806167006492615,
-0.010323877446353436,
-0.04552121460437775,
-0.01818065159022808,
-0.0068572815507650375,
0.011968612670898438,
-0.03069329261779785,
-0.030845114961266518,
-0.026442283764481544,
0.0055383299477398396,
0.007072362117469311,
-0.015878021717071533,
-0.00030364346457645297,
0.026745928451418877,
-0.015333994291722775,
-0.011007075197994709,
0.005443441681563854,
0.021811721846461296,
0.00792635977268219,
-0.02211536467075348,
-0.010507328435778618,
-0.014853226020932198,
-0.012493662536144257,
0.050885580480098724,
-0.035273246467113495,
0.0016558057395741343,
-0.015511119738221169,
-0.035728711634874344,
0.05642707645893097,
-0.0181426964700222,
-0.009583746083080769,
0.0330212265253067,
-0.00047483827802352607,
-0.014094117097556591,
-0.013208489865064621,
-0.03390685096383095,
-0.018648769706487656,
0.015738852322101593,
0.02047063037753105,
0.01616901345551014,
0.024949369952082634,
0.03413458541035652,
0.036310695111751556,
-0.008710771799087524,
-0.028871431946754456,
0.011045030318200588,
0.002908335067331791,
0.015549074858427048,
0.019458483904600143,
0.04175097495317459,
-0.011045030318200588,
-0.020331459119915962,
0.007357027847319841,
0.0017617646371945739,
-0.036664947867393494,
-0.03170543909072876,
0.008881570771336555,
0.00996330101042986,
-0.010526305995881557,
0.01112726703286171,
0.014410411939024925,
0.02639167755842209,
-0.043370407074689865,
-0.00577238854020834,
-0.033704422414302826,
0.048203397542238235,
-0.005199894309043884,
-0.008090833202004433,
-0.00862220861017704,
-0.029858272522687912,
0.00376391364261508,
0.010153078474104404,
0.015865370631217957,
0.010488350875675678,
-0.020420022308826447,
0.005506700370460749,
-0.04397769272327423,
-0.02200149931013584,
-0.02346910908818245,
-0.0139422956854105,
-0.029402807354927063,
-0.03261636942625046,
-0.005854625254869461,
-0.03782891482114792,
-0.03729753941297531,
-0.017788445577025414,
-0.0376770906150341,
-0.029225682839751244,
-0.006844629533588886,
-0.05222667381167412,
0.008305913768708706,
-0.00781249301508069,
-0.011165223084390163,
0.005079702008515596,
-0.013284401036798954,
-0.01957235112786293,
0.013537437655031681,
0.006515682674944401,
-0.0007397355511784554,
-0.013689259067177773,
0.012866890989243984,
-0.010678128339350224,
-0.0013948620762676,
-0.07383596897125244,
-0.005247338674962521,
0.006610570941120386,
-0.02339319698512554,
0.00582299567759037,
0.02249491959810257,
-0.011911679990589619,
-0.011184200644493103,
0.010886883363127708,
0.01648530922830105,
-0.001016098540276289,
0.021217087283730507,
0.0038018689956516027,
0.00478871027007699,
0.01943318173289299,
-0.025442790240049362,
-0.0010066096438094974,
-0.018522251397371292,
0.035475678741931915,
0.014245938509702682,
-0.015182172879576683,
0.03967607766389847,
-0.014891181141138077,
-0.016282880678772926,
0.03003539890050888,
0.01936992257833481,
-0.0005981934373266995,
0.0025746433530002832,
-0.0027992131654173136,
-0.010216336697340012,
-0.0015364042483270168,
-0.032768189907073975,
-0.029073860496282578,
-0.0017807423137128353,
-0.0004127653082832694,
-0.03362851217389107,
-0.011500495485961437,
-0.016333486884832382,
0.033426083624362946,
-0.009830457158386707,
-0.031072847545146942,
-0.020382067188620567,
-0.011411933228373528,
-0.03076920285820961,
0.05232788994908333,
0.01869937591254711,
-0.007338050287216902,
0.01981273479759693,
-0.006964821834117174,
-0.011051356792449951,
-0.0004254171217326075,
-0.010304899886250496,
-0.005914721637964249,
0.02492406778037548,
-0.010791994631290436,
0.038815755397081375,
0.035096123814582825,
0.023140162229537964,
-0.011184200644493103,
0.03261636942625046,
0.021432166919112206,
-0.028011107817292213,
0.0004890715354122221,
-0.022659393027424812,
-0.003542507067322731,
-0.030060701072216034,
0.008634860627353191,
0.11842094361782074,
-0.018130045384168625,
0.019407877698540688,
0.014878529123961926,
0.008527320809662342,
-0.0269736610352993,
0.019698869436979294,
0.004817177075892687,
0.019825387746095657,
-0.02305159904062748,
0.01315788272768259,
0.010981771163642406,
0.0218370258808136,
0.03456474840641022,
0.01769988238811493,
-0.013233793899416924,
-0.0016162687679752707,
0.014941788278520107,
0.007837796583771706,
-0.006547311786562204,
0.00003768361420952715,
0.017269721254706383,
-0.01915484108030796,
0.03284410014748573,
0.005070213228464127,
-0.013727214187383652,
-0.003820846788585186,
0.0054023233242332935,
0.022608784958720207,
0.03598174825310707,
0.032768189907073975,
-0.019483787938952446,
0.0218370258808136,
0.0009813060751184821,
-0.014562234282493591,
-0.009292755275964737,
-0.008755053393542767,
-0.01589067466557026,
-0.009121955372393131,
0.003514040494337678,
0.00862220861017704,
-0.002939964411780238,
0.03795543313026428,
0.013347660191357136,
0.010273270308971405,
0.011026052758097649,
-0.022102713584899902,
-0.020521236583590508,
0.003191419178619981,
-0.04898780956864357,
0.02436738647520542,
0.030465560033917427,
0.009254799224436283,
0.004567303694784641,
-0.006566289812326431,
-0.013044016435742378,
0.01399290282279253,
0.01742154359817505,
0.01692812331020832,
-0.011709250509738922,
-0.01013409998267889,
0.005377019289880991,
-0.008780356496572495,
0.012854239903390408,
0.00902074109762907
] | 2024-12-31 | 45 | 39737899 | [
"mCRPC patients",
"BPX-601 cell expansion",
"GoCAR-T® cell activation",
"patients",
"GoCAR-T® cells",
"chimeric antigen receptor-T cell activity",
"≥50% reduction",
"Rimiducid",
"rimiducid",
"mCRPC",
"circulating inflammatory cytokines",
"peripheral blood",
"Secondary objectives",
"Primary objectives",
"tumor infiltration",
"partial responses",
"an investigational autologous PSCA-directed GoCAR-T® cell product",
"pharmacological activation",
"tolerability",
"continued dose-optimization",
"results",
"efficacy",
"the activating dimerizer rimiducid",
"castration-resistant prostate cancer",
"safety",
"the highest-dose mCRPC cohort",
"NCT02744287",
"BPX-601",
"MyD88",
"Two mCRPC patients"
] | [] | 0 | 10.1038/s41467-024-53220-6 | [
"Stein",
"Dumbrava",
"Teply",
"Gergis",
"Guiterrez",
"Reshef",
"Subudhi",
"Jacquemont",
"Senesac",
"Bayle",
"Scripture",
"Chatwal",
"Bilen",
"Stadler",
"Becerra"
] | [
"Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.",
"The University of Texas MD Anderson Cancer Center, Houston, TX, USA. [email protected].",
"University of Nebraska Medical Center, Omaha, NE, USA.",
"Thomas Jefferson University, Philadelphia, PA, USA.",
"Hackensack University Medical Center, Hackensack, NJ, USA.",
"Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.",
"The University of Texas MD Anderson Cancer Center, Houston, TX, USA.",
"Bellicum Pharmaceuticals, Inc., Houston, TX, USA.",
"Bellicum Pharmaceuticals, Inc., Houston, TX, USA.",
"Bellicum Pharmaceuticals, Inc., Houston, TX, USA.",
"Bellicum Pharmaceuticals, Inc., Houston, TX, USA.",
"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.",
"Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA, USA.",
"University of Chicago, Chicago, IL, USA.",
"Baylor University Medical Center, Dallas, TX, USA.\nHoag Family Cancer Institute, Newport Beach, CA, USA."
] | [
"39737899",
"36765623",
"36906275",
"36853475",
"33824268",
"21383499",
"9724721",
"28697888",
"28801306",
"30740516",
"9465086",
"10973799",
"12516096",
"22778595",
"16604582",
"20501618",
"22020316",
"22553195",
"24694017",
"38867077",
"10713670",
"31023743",
"11504275",
"17062687",
"34263927",
"35314843",
"29385370",
"35534566",
"34386775",
"27324746",
"23246260",
"28924019",
"30407609",
"32181801",
"32798213",
"34788386",
"30782611",
"0",
"34724386",
"30804212",
"26254266",
"34264268",
"19097774",
"26903579",
"30592986"
] | [] | 5.729406 | 5.627012 |
39735543 | 91 | The approval of chimeric antigen receptor (CAR) T cell therapies for the treatment of B cell malignancies has fueled the development of numerous
The CAR comprises a TROP2 specific single-chain variable fragment (scFv) fused to a truncated CD89 which requires association with the FcRγ signal adapter to trigger myeloid-specific cell activation. The mRNA encoding the TROP2 CAR was encapsulated in LNPs. Co-immunoprecipitation, flow cytometry and enzyme-linked immunosorbent assay (ELISA) were used to measure CAR expression and functional activity
These findings demonstrate that myeloid cells can be directly engineered | [
0.01903236098587513,
-0.0033434443175792694,
0.020786870270967484,
0.015895158052444458,
-0.01846301555633545,
-0.0417131707072258,
-0.011415930464863777,
-0.007604810409247875,
-0.0009752922342158854,
-0.008871310390532017,
-0.011392692103981972,
-0.0034857802093029022,
-0.05428521707653999,
0.013675877824425697,
0.02811862714588642,
-0.058468155562877655,
0.027909480035305023,
-0.015720868483185768,
0.019043980166316032,
0.026747554540634155,
0.014291699044406414,
-0.0031952986028045416,
-0.02707289345562458,
0.00002873045377782546,
-0.021751267835497856,
-0.03276633471250534,
0.012525570578873158,
0.03715841844677925,
-0.03362616151571274,
-0.04340958222746849,
0.022146323695778847,
-0.039133694022893906,
-0.01890454813838005,
0.003985408693552017,
-0.019566847011446953,
0.022018512710928917,
0.02498142421245575,
-0.007343376986682415,
-0.0351831428706646,
-0.030535435304045677,
0.008145106956362724,
0.02681726962327957,
0.008092819713056087,
0.07394501566886902,
-0.045431334525346756,
-0.012188611552119255,
-0.015267717652022839,
-0.026561645790934563,
0.002643383340910077,
0.013594542630016804,
-0.023784641176462173,
-0.0015526246279478073,
-0.04531514272093773,
0.026608122512698174,
-0.08175316452980042,
0.05791042745113373,
-0.04415321722626686,
0.010939540341496468,
-0.01776585914194584,
0.0009847328765317798,
-0.0059723034501075745,
-0.007227184250950813,
0.01995028182864189,
-0.02038019523024559,
-0.05224022641777992,
0.014221983030438423,
-0.05609782412648201,
-0.016266973689198494,
0.011381072923541069,
0.043386343866586685,
-0.0007567047723568976,
-0.018544351682066917,
0.011224212124943733,
0.002833648817613721,
0.05121773108839989,
0.0008365872781723738,
-0.014198744669556618,
0.056330207735300064,
-0.002021752530708909,
-0.005411673802882433,
0.0456404834985733,
-0.011665744706988335,
-0.0033928260672837496,
-0.08161373436450958,
-0.00003628751801443286,
-0.0002499957918189466,
0.013304061256349087,
-0.013118152506649494,
-0.05688793212175369,
0.013234345242381096,
0.005949065089225769,
0.0365077368915081,
-0.0586540624499321,
0.05149659514427185,
-0.0232385341078043,
0.014094171114265919,
-0.05665554851293564,
-0.05619077757000923,
0.026956699788570404,
0.048522062599658966,
0.0330219566822052,
0.004409512039273977,
-0.01538391038775444,
-0.02215794287621975,
0.05024171248078346,
0.014942377805709839,
-0.02542295679450035,
-0.008673783391714096,
0.003093630075454712,
-0.03864568471908569,
0.0712493509054184,
-0.016348309814929962,
-0.01873025856912136,
0.0656256228685379,
0.011259070597589016,
-0.06873958557844162,
0.0025010472163558006,
0.011049923487007618,
-0.004819091409444809,
0.011398501694202423,
-0.005408769007772207,
0.025655342265963554,
0.03864568471908569,
-0.043734923005104065,
0.013327299617230892,
-0.01091049239039421,
0.08393758535385132,
0.0032708237413316965,
-0.026306021958589554,
-0.051821932196617126,
-0.006216308102011681,
-0.024307508021593094,
0.03676336258649826,
-0.014768089167773724,
-0.06088495999574661,
0.0019825375638902187,
-0.0012694050092250109,
-0.02572505734860897,
-0.06367358565330505,
0.009376748465001583,
0.009899616241455078,
-0.028002435341477394,
0.002717456081882119,
-0.019009120762348175,
-0.028211580589413643,
-0.045989058911800385,
-0.027584141120314598,
0.028002435341477394,
0.007389854174107313,
0.0006804533768445253,
-0.023587113246321678,
0.05010228231549263,
0.05818929150700569,
0.006425454746931791,
-0.0031982033979147673,
-0.060838483273983,
-0.010224955156445503,
0.05814281478524208,
-0.006123353727161884,
-0.04889387637376785,
-0.018370062112808228,
0.024307508021593094,
-0.021391071379184723,
-0.013931501656770706,
0.01616240106523037,
-0.007628049235790968,
-0.0065009803511202335,
0.031046682968735695,
-0.07292252033948898,
0.014256841503083706,
-0.02237870916724205,
-0.034393031150102615,
-0.08667973428964615,
-0.028839021921157837,
-0.05879349261522293,
0.003863406367599964,
0.008929407224059105,
0.0033695874735713005,
-0.03436979278922081,
-0.023610351607203484,
0.010654868558049202,
0.009121124632656574,
0.016174020245671272,
-0.009771804325282574,
0.0027130988892167807,
0.019055599346756935,
0.006965750828385353,
0.036949269473552704,
-0.02025238238275051,
-0.020484767854213715,
0.016801461577415466,
0.04454827308654785,
0.0708310529589653,
0.005060190800577402,
0.009876376949250698,
-0.00586482509970665,
0.024586370214819908,
0.019346080720424652,
-0.016720125451683998,
-0.03815767541527748,
0.03785557299852371,
-0.021751267835497856,
-0.018021482974290848,
-0.011793556623160839,
-0.025957442820072174,
-0.005333243869245052,
-0.011200973764061928,
0.022041751071810722,
-0.0021176114678382874,
0.006140782963484526,
0.05363453924655914,
0.013617781922221184,
-0.013664258643984795,
0.05149659514427185,
-0.04264271259307861,
-0.0026070731692016125,
-0.005815443582832813,
0.03522961959242821,
0.014617038890719414,
-0.010875633917748928,
-0.03511342778801918,
-0.02098439633846283,
0.0035642103757709265,
0.019845709204673767,
-0.05558657646179199,
0.026306021958589554,
-0.010335338301956654,
-0.049823418259620667,
-0.004348510876297951,
-0.032394517213106155,
-0.00009540507744532079,
0.015151524916291237,
-0.003154631005600095,
-0.045384857803583145,
-0.03197622299194336,
0.01681308075785637,
0.03950550779700279,
-0.00016675464576110244,
0.03859920799732208,
-0.015720868483185768,
-0.003462541615590453,
0.01283929031342268,
0.07798852026462555,
-0.00879578571766615,
-0.004101601429283619,
-0.009789233095943928,
0.009266366250813007,
-0.019659800454974174,
0.04382787644863129,
-0.018695401027798653,
0.012351281009614468,
0.0011350571876391768,
-0.004412416834384203,
0.00854016188532114,
0.006553266663104296,
0.037181656807661057,
0.025864489376544952,
-0.017231373116374016,
0.008150916546583176,
-0.01316463015973568,
0.02220441959798336,
0.01912531442940235,
-0.04336310550570488,
-0.014558942057192326,
-0.054517604410648346,
-0.01010295283049345,
0.0021001826971769333,
0.03416064754128456,
0.03325434401631355,
0.016998987644910812,
0.01812605746090412,
-0.0005116108804941177,
0.030605150386691093,
-0.003665878903120756,
-0.06762413680553436,
0.023482538759708405,
-0.011346214450895786,
0.021518884226679802,
0.01531419437378645,
0.009452274069190025,
-0.011241640895605087,
-0.0018808689201250672,
0.010701345279812813,
0.02472580038011074,
-0.024191314354538918,
-0.018962644040584564,
0.016847938299179077,
-0.01306005660444498,
0.009551038034260273,
0.01179936621338129,
0.020844966173171997,
-0.0017385329119861126,
-0.030396003276109695,
-0.03555495664477348,
-0.011869081296026707,
0.030953727662563324,
-0.017440520226955414,
-0.020844966173171997,
-0.03646126016974449,
0.012374520301818848,
-0.03815767541527748,
-0.005760252010077238,
-0.025004664435982704,
-0.018091199919581413,
0.006326691247522831,
0.033440250903367996,
0.01206079963594675,
-0.04010971263051033,
0.034788087010383606,
0.027746811509132385,
0.008929407224059105,
-0.03160440921783447,
-0.003436398459598422,
0.02211146615445614,
0.04196879267692566,
-0.012246707454323769,
0.0025736677926033735,
-0.030581912025809288,
0.04001675546169281,
-0.04847558215260506,
-0.03220861032605171,
0.010805918835103512,
-0.013745593838393688,
0.014396272599697113,
-0.00045896106166765094,
-0.029443223029375076,
-0.020926300436258316,
-0.016266973689198494,
0.019578466191887856,
-0.03241775557398796,
0.003035533707588911,
-0.021100590005517006,
0.07422388345003128,
-0.00788367260247469,
0.004485037177801132,
0.0011924273567274213,
-0.028258059173822403,
-0.03664717078208923,
0.02402864582836628,
0.01777747832238674,
0.013234345242381096,
0.008772547356784344,
-0.0460587777197361,
0.05484294146299362,
0.0089061688631773,
0.01436141412705183,
0.03225508704781532,
0.01010295283049345,
-0.013397015631198883,
-0.0026884078979492188,
-0.009771804325282574,
0.007895291782915592,
0.017103562131524086,
-0.02377302199602127,
-0.013199487701058388,
0.03381206840276718,
-0.009080457501113415,
-0.004206174984574318,
0.03097696788609028,
-0.005516247358173132,
0.01895102486014366,
0.003413159865885973,
-0.029396746307611465,
0.029396746307611465,
0.03964494168758392,
0.05628373101353645,
0.0005450162570923567,
0.02567858062684536,
-0.0321621336042881,
-0.018614066764712334,
-0.014256841503083706,
-0.012304804287850857,
0.017022226005792618,
-0.004609944298863411,
0.006744984537363052,
0.023343108594417572,
0.028862260282039642,
0.019102076068520546,
0.027305278927087784,
-0.028351012617349625,
0.05925826355814934,
-0.027165846899151802,
-0.0065765054896473885,
-0.02103087492287159,
-0.006245356053113937,
0.008836452849209309,
0.013896644115447998,
-0.028211580589413643,
-0.030535435304045677,
0.05163602530956268,
-0.021646695211529732,
-0.03590353578329086,
0.01833520457148552,
-0.0064719319343566895,
-0.04471094161272049,
0.06543971598148346,
0.02577153593301773,
0.06841424852609634,
0.06093144044280052,
0.021019255742430687,
-0.0008431230671703815,
-0.027305278927087784,
0.0075757624581456184,
-0.033788830041885376,
0.010219145566225052,
-0.010422483086585999,
0.044037025421857834,
0.018660543486475945,
0.007285280618816614,
-0.027584141120314598,
-0.029698846861720085,
-0.006408025976270437,
0.023180438205599785,
0.03706546500325203,
-0.0006052912212908268,
-0.003398635657504201,
-0.042387086898088455,
0.036042965948581696,
-0.006977370008826256,
0.036949269473552704,
0.04089982062578201,
-0.010178478434681892,
0.017045466229319572,
-0.011299737729132175,
0.011200973764061928,
-0.0016760793514549732,
0.03667040914297104,
0.029350269585847855,
-0.0002454570203553885,
-0.009771804325282574,
-0.03188326954841614,
0.011032494716346264,
0.01790529116988182,
-0.030000949278473854,
0.011956226080656052,
0.00820901244878769,
-0.008667973801493645,
0.014431130141019821,
-0.041434306651353836,
0.042944811284542084,
0.007081943564116955,
0.036298591643571854,
0.04159697890281677,
-0.013629401102662086,
0.011747078970074654,
0.0202059056609869,
-0.010875633917748928,
-0.002097277669236064,
-0.03667040914297104,
0.013931501656770706,
-0.015256098471581936,
-0.004546038340777159,
-0.013582923449575901,
0.002235256601125002,
-0.04457151144742966,
-0.014152267947793007,
0.03320786729454994,
-0.0430145263671875,
0.011044113896787167,
0.02876930683851242,
0.031650885939598083,
-0.03759995102882385,
0.012572047300636768,
-0.034788087010383606,
0.0034915897995233536,
0.03381206840276718,
0.013606161810457706,
-0.03111639805138111,
0.02881578356027603,
-0.03966818004846573,
-0.0035061140079051256,
-0.013489969074726105,
-0.012351281009614468,
0.03964494168758392,
-0.01746375858783722,
0.03680983930826187,
0.03218537196516991,
0.010817538015544415,
0.038436535745859146,
0.012932244688272476,
-0.010027428157627583,
-0.01036438625305891,
-0.039040736854076385,
-0.009307033382356167,
0.01708032377064228,
0.043130721896886826,
-0.010416673496365547,
0.004641897510737181,
-0.04315396025776863,
0.010126191191375256,
0.0009752922342158854,
-0.0003732689656317234,
-0.00899331271648407,
-0.010294671170413494,
-0.007506046909838915,
-0.023738162592053413,
-0.010126191191375256,
-0.009237317368388176,
-0.002406640676781535,
-0.008017294108867645,
-0.011264880187809467,
0.03680983930826187,
0.0012490712106227875,
0.018009863793849945,
0.028490444645285606,
0.043944068253040314,
0.022216038778424263,
0.03550847992300987,
-0.01473323069512844,
0.03581058233976364,
-0.010172668844461441,
-0.007064514793455601,
0.018451396375894547,
-0.025748297572135925,
-0.04048152640461922,
-0.03581058233976364,
-0.044129978865385056,
-0.010747822001576424,
-0.017347566783428192,
-0.021739648655056953,
-0.016615552827715874,
-0.01768452487885952,
-0.010143620893359184,
0.007860434241592884,
0.014570561237633228,
-0.028351012617349625,
-0.010590962134301662,
-0.0808236226439476,
-0.044780656695365906,
-0.049079786986112595,
0.044780656695365906,
-0.013559685088694096,
0.011886510998010635,
0.01206079963594675,
-0.006948322057723999,
-0.00991123542189598,
-0.035950012505054474,
0.0352063812315464,
-0.008714450523257256,
-0.03815767541527748,
-0.0017530570039525628,
-0.021588599309325218,
0.02581801265478134,
-0.03597325086593628,
-0.008534352295100689,
0.021995272487401962,
0.005571438930928707,
-0.03155792877078056,
0.02137945219874382,
-0.010922111570835114,
0.036786600947380066,
-0.02163507603108883,
0.009097886271774769,
0.005394245032221079,
0.00595487467944622,
-0.03320786729454994,
0.006744984537363052,
-0.03011714108288288,
-0.004941093269735575,
-0.05549362301826477,
-0.010422483086585999,
-0.012397758662700653,
0.011979464441537857,
-0.015105047263205051,
-0.017975006252527237,
0.016871176660060883,
-0.005545295309275389,
0.006344120018184185,
-0.0525655671954155,
0.029234077781438828,
-0.015616295859217644,
0.0015293860342353582,
0.009173411875963211,
0.03318462893366814,
0.03364939987659454,
0.012084037996828556,
-0.022436805069446564,
0.012409377843141556,
-0.02268080972135067,
0.01301357988268137,
-0.020740391686558723,
-0.035299334675073624,
0.011421740055084229,
0.019090456888079643,
-0.00810443889349699,
0.02011295221745968,
-0.0521472729742527,
-0.025469433516263962,
-0.018672162666916847,
0.02372654341161251,
0.030047426000237465,
0.0025286430027335882,
0.022483281791210175,
0.05279795080423355,
-0.037042222917079926,
0.022889956831932068,
0.015360672026872635,
0.014431130141019821,
-0.05056705325841904,
0.017045466229319572,
0.009004931896924973,
0.008174154907464981,
-0.010178478434681892,
-0.024609608575701714,
-0.012850909493863583,
0.012513951398432255,
0.0022933529689908028,
-0.017928529530763626,
-0.016650410369038582,
0.012606904841959476,
0.04926569387316704,
0.030605150386691093,
-0.008301966823637486,
0.003601972945034504,
0.013489969074726105,
0.012490712106227875,
-0.0199851393699646,
0.010259813629090786,
-0.006355739198625088,
-0.03392826020717621,
-0.032301563769578934,
-0.011450788006186485,
-0.018067961558699608,
-0.0003605603997129947,
-0.009092076681554317,
-0.04296804964542389,
-0.006425454746931791,
0.019311223179101944,
0.004493751563131809,
0.013187868520617485,
-0.003355063498020172,
-0.05000932887196541,
0.014768089167773724,
0.04392082989215851,
-0.001809700857847929,
-0.053169768303632736,
0.020531246438622475,
-0.010341147892177105,
-0.007866243831813335,
0.019973520189523697,
0.00973113626241684,
-0.002413902897387743,
-0.007023847196251154,
-0.04661650210618973,
0.019566847011446953,
-0.013373777270317078,
-0.02902493067085743,
0.021402690559625626,
0.02772357128560543,
-0.004429845605045557,
-0.02642221376299858,
-0.015744106844067574,
0.01907883770763874,
-0.024307508021593094,
0.007738431915640831,
-0.04724394157528877,
-0.021704791113734245,
0.007134230341762304,
0.06483551114797592,
0.07654773443937302,
-0.021588599309325218,
0.024051884189248085,
-0.010323719121515751,
-0.00988218653947115,
-0.023192057386040688,
0.01725461147725582,
0.003456732025370002,
0.0030500576831400394,
0.005835777148604393,
0.00991123542189598,
0.09676525741815567,
0.025213809683918953,
0.007540904451161623,
-0.03790204972028732,
-0.01421036384999752,
-0.00532162468880415,
0.00630926201120019,
-0.034950755536556244,
-0.031952984631061554,
0.01594163477420807,
0.0006583041395060718,
0.01431493740528822,
-0.01882321387529373,
-0.049683988094329834,
0.015174763277173042,
0.004023171495646238,
0.003445112844929099,
-0.010178478434681892,
0.005185097921639681,
-0.004392083268612623,
-0.02024076320230961,
-0.0014328008983284235,
-0.00320982257835567,
0.0020725869107991457,
0.036135923117399216,
-0.016894415020942688,
-0.015558199025690556,
-0.0103179095312953,
-0.033138152211904526,
-0.0102133359760046,
0.04440883919596672,
0.02277376502752304,
0.038738638162612915,
-0.03945903107523918,
0.026003921404480934,
-0.012665001675486565,
-0.008673783391714096,
-0.012153754010796547,
0.023621970787644386,
0.059165310114622116,
0.01903236098587513,
-0.01595325395464897,
-0.024586370214819908,
-0.027212323620915413,
-0.024353984743356705,
0.012176992371678352,
0.01201432291418314,
0.03155792877078056,
0.00884226243942976,
0.0208565853536129,
0.0021161590702831745,
0.03592677414417267,
-0.011357833631336689,
0.005696346051990986,
0.030651627108454704,
0.01110220979899168,
-0.026398975402116776,
0.05554009974002838,
-0.021100590005517006,
-0.004084172658622265,
-0.004133554175496101,
-0.01630183309316635,
-0.03488104045391083,
0.00854016188532114,
-0.0075002373196184635,
0.02663136087357998,
0.0047668046317994595,
-0.021530503407120705,
-0.02772357128560543,
-0.04001675546169281,
0.030907250940799713,
-0.030884012579917908,
-0.019613323733210564,
0.022518141195178032,
-0.00831939559429884,
0.025864489376544952,
0.02642221376299858,
0.006739174947142601,
-0.005946160294115543,
-0.019752753898501396,
-0.027165846899151802,
0.007662906777113676,
-0.0030181047040969133,
-0.014256841503083706,
-0.013071675784885883,
-0.02972208708524704,
0.00542038818821311,
0.0014821827644482255,
-0.02937350794672966,
-0.016754982993006706,
-0.02602715976536274,
0.001850368338637054,
-0.005925826262682676,
-0.005025333259254694,
0.0032127273734658957,
-0.010509627871215343,
-0.005129906814545393,
0.0005141525762155652,
-0.003389921272173524,
0.020403433591127396,
-0.019264744594693184,
0.001334763364866376,
-0.007012228015810251,
-0.02463284693658352,
-0.013245965354144573,
0.024586370214819908,
-0.018370062112808228,
0.02120516262948513,
-0.0099925696849823,
0.02797919698059559,
-0.031952984631061554,
-0.005353577435016632,
-0.028490444645285606,
0.0007400020840577781,
-0.0050660003907978535,
0.010341147892177105,
-0.004313652869313955,
0.02697993814945221,
-0.027142608538269997,
-0.0035903535317629576,
-0.016104305163025856,
0.03141849860548973,
-0.040783628821372986,
-0.005371006205677986,
0.001580220414325595,
0.044339124113321304,
0.03327758237719536,
-0.10884929448366165,
-0.0364844985306263,
-0.00888292957097292,
-0.021669933572411537,
-0.026956699788570404,
0.027189085260033607,
-0.004502465948462486,
-0.011718031018972397,
-0.004758090246468782,
-0.010753631591796875,
-0.010683916509151459,
-0.008377491496503353,
-0.006512599531561136,
-0.004967236891388893,
0.009806661866605282,
-0.020484767854213715,
-0.02593420445919037,
-0.04724394157528877,
-0.0061988793313503265,
0.046430591493844986,
0.0036135921254754066,
0.006646221037954092,
-0.032952241599559784,
0.04959103465080261,
-0.022924814373254776,
0.02220441959798336,
-0.010178478434681892,
-0.0005210515228100121,
-0.045779913663864136,
0.011526313610374928,
0.031139636412262917,
0.02359873242676258,
-0.014663515612483025,
0.0071981362998485565,
0.00012272851017769426,
-0.03732108697295189,
0.012606904841959476,
-0.02563210390508175,
-0.005493008531630039,
-0.0026811459101736546,
0.0015235764440149069,
0.004168412182480097,
0.0003845251339953393,
0.020449910312891006,
0.018219010904431343,
0.003273728536441922,
-0.029257316142320633,
-0.010573533363640308,
0.016266973689198494,
0.0017792002763599157,
0.047731950879096985,
-0.04589610546827316,
-0.02293643355369568,
0.012409377843141556,
0.0012105824425816536,
-0.048522062599658966,
0.009144363924860954,
0.0364844985306263,
0.029559416696429253,
0.01073039323091507,
-0.015105047263205051,
0.06186097860336304,
0.03618239983916283,
-0.007116801105439663,
-0.007256232667714357,
-0.025469433516263962,
-0.027584141120314598,
0.055075328797101974,
-0.0378090962767601,
0.02285509929060936,
-0.023703305050730705,
-0.004101601429283619,
-0.01590677723288536,
0.012374520301818848,
-0.004261366557329893,
0.010794299654662609,
-0.020519627258181572,
-0.0050689056515693665,
-0.00515895476564765,
0.017533475533127785,
-0.016673648729920387,
-0.02068229578435421,
-0.003578734351322055,
-0.0032156321685761213,
-0.01898588240146637,
-0.0106432493776083,
0.013397015631198883,
0.004816186148673296,
0.0042381277307868,
-0.0063673583790659904,
-0.004880092106759548,
-0.0021510168444365263,
0.008081200532615185,
0.0031807743944227695,
-0.013931501656770706,
-0.023912452161312103,
-0.06618335098028183,
0.00901655200868845,
-0.007099372334778309,
-0.021832603961229324,
0.0556330531835556,
-0.010108762420713902,
0.007796528283506632,
-0.05335567519068718,
-0.035438764840364456,
-0.028234820812940598,
0.04364196956157684,
-0.014396272599697113,
0.0029266029596328735,
-0.033788830041885376,
0.02902493067085743,
0.0008750761044211686,
0.01201432291418314,
-0.01490752026438713,
-0.006744984537363052,
-0.0005907671293243766,
0.03615916147828102,
0.00851692259311676,
0.005562724079936743,
0.009609133936464787,
0.055679529905319214,
0.018277106806635857,
-0.001728366012685001,
-0.016046209260821342,
-0.020171048119664192,
0.0021960416343063116,
0.015930015593767166,
0.025887727737426758,
0.022390328347682953,
-0.014872662723064423,
0.0036862127017229795,
-0.02311072312295437,
-0.004839424975216389,
-0.013722354546189308,
0.014024456031620502,
0.03720489516854286,
0.011921368539333344,
0.023610351607203484,
-0.014884281903505325,
0.035392288118600845,
-0.003732689656317234,
-0.004633183125406504,
0.008819024078547955,
-0.02793271839618683,
0.027909480035305023,
-0.013757213018834591,
-0.043525777757167816,
0.04787138104438782,
0.0007367341895587742,
0.01963656209409237,
-0.042177941650152206,
0.036089446395635605,
0.01306005660444498,
0.044780656695365906,
-0.004072553478181362,
0.025585627183318138,
0.03093048930168152,
-0.03515990450978279,
-0.02581801265478134,
0.025469433516263962,
-0.025399718433618546,
0.05270499736070633,
-0.008389110676944256,
-0.04071391373872757,
0.0006401489954441786,
-0.004929474089294672,
0.0032388707622885704,
0.021797746419906616,
0.02572505734860897,
0.03158116713166237,
0.02046152949333191,
-0.07682659476995468,
0.054331693798303604,
-0.016359928995370865,
-0.05056705325841904,
0.010178478434681892,
0.041085731238126755,
0.007767480332404375,
0.008162535727024078,
-0.014953996986150742,
-0.032952241599559784,
-0.003657164517790079,
0.025469433516263962,
0.047034796327352524,
0.01968303881585598,
-0.012920625507831573,
0.002277376363053918,
-0.026491930708289146,
0.011264880187809467,
0.03423036262392998,
-0.04657002538442612,
-0.028536921367049217,
-0.004633183125406504,
0.06274404376745224,
0.04045828804373741,
-0.008935216814279556,
-0.042526520788669586,
0.023041008040308952,
-0.04787138104438782,
-0.02837425097823143,
-0.051682502031326294,
0.03522961959242821,
0.03646126016974449,
-0.025585627183318138,
-0.007250423077493906,
0.014558942057192326,
0.018648924306035042,
-0.03915693238377571,
0.005327434279024601,
0.05005580559372902,
0.00094116065884009,
0.04819672182202339,
-0.017707763239741325,
0.03306843340396881,
0.027537664398550987,
-0.031697362661361694,
0.02293643355369568,
-0.011288118548691273,
-0.023389585316181183,
-0.020473148673772812,
-0.03311491385102272,
-0.02398216724395752,
0.011781937442719936,
-0.02763061784207821,
0.018532732501626015,
0.009719517081975937,
0.014512465335428715,
0.004511180799454451,
-0.005002094432711601,
0.013199487701058388,
-0.03420712426304817,
0.02402864582836628,
0.027398232370615005,
0.016313452273607254,
0.00964399240911007,
-0.03046572022140026,
-0.004923664499074221,
-0.03697250783443451,
0.018219010904431343,
-0.014942377805709839,
0.030907250940799713,
0.007970817387104034,
0.0030093903187662363,
0.0036949270870536566,
-0.013954740017652512,
0.018358442932367325,
0.038041479885578156,
-0.020914681255817413,
0.012142134830355644,
0.006646221037954092,
-0.008575019426643848,
0.013257584534585476,
0.01838168129324913,
0.04141106829047203,
0.046082016080617905,
0.013083294965326786,
0.0021466596517711878,
0.026840507984161377,
0.024563131853938103,
0.018195772543549538,
0.0038517871871590614,
0.006599743850529194,
0.019752753898501396,
0.005565629340708256,
0.04524542763829231,
-0.021216781809926033,
0.0038401680067181587,
-0.0030151999089866877,
0.019717896357178688,
0.03653097525238991,
0.0339050218462944,
0.013803689740598202,
0.007773289922624826,
0.0010464602382853627,
-0.00037145346868783236,
-0.005295481067150831,
0.026515169069170952,
-0.016929272562265396,
-0.014512465335428715,
0.02264595218002796,
-0.03076782077550888,
-0.011113828979432583,
-0.05358806252479553,
0.008011484518647194,
0.013524827547371387,
0.018625685945153236,
0.004624468274414539,
0.013943120837211609,
-0.00017537831445224583,
-0.00641964515671134,
-0.019799232482910156,
-0.005440722219645977,
-0.01486104354262352,
-0.026306021958589554,
-0.0031139636412262917,
-0.02728204056620598,
-0.012304804287850857,
-0.0024502130690962076,
0.006233736872673035,
-0.014070932753384113,
0.0139082632958889,
0.027584141120314598,
-0.017219753935933113,
-0.03683307766914368,
0.020345337688922882,
-0.0015410053310915828,
-0.026584884151816368,
-0.036391545087099075,
0.04331662878394127,
-0.004403702449053526,
-0.0280256737023592,
0.014930758625268936,
0.007331757806241512,
-0.006152402143925428,
0.016569076105952263,
0.031348783522844315,
-0.040388572961091995,
0.018265487626194954,
0.002777004847303033,
-0.0023529017344117165,
-0.027305278927087784,
0.0032475851476192474,
-0.003404445480555296,
-0.007552523631602526,
-0.020008377730846405,
0.008859691210091114,
0.00555110489949584,
-0.021147066727280617,
-0.002570762997493148,
-0.02512085624039173,
0.03411417081952095,
-0.008482065051794052,
0.00906302873045206,
-0.0025722153950482607,
-0.03676336258649826,
0.0023049721494317055,
0.027467947453260422,
-0.004031885880976915,
0.0018489159410819411,
0.025701818987727165,
-0.005658583249896765,
0.019346080720424652,
-0.0060013518668711185,
0.02777004987001419,
0.029605893418192863,
-0.006959941238164902,
0.009394178166985512,
-0.02277376502752304,
-0.002989056520164013,
-0.014024456031620502,
0.046941839158535004,
-0.022274136543273926,
-0.03611268475651741,
0.047127749770879745,
0.001110366196371615,
-0.015105047263205051,
0.0022367089986801147,
0.018521111458539963,
0.011654125526547432,
-0.03318462893366814,
-0.0064893607050180435,
0.02172802947461605,
0.04457151144742966,
-0.010666487738490105,
0.006617172621190548,
0.00653002830222249,
-0.027165846899151802,
-0.031000206246972084,
-0.0010791394161060452,
0.012420997023582458,
0.02711937017738819,
0.004903330933302641,
-0.004511180799454451,
0.019717896357178688,
-0.0006895309197716415,
-0.009591705165803432,
0.04350253567099571,
0.023401204496622086,
-0.005949065089225769,
0.030884012579917908,
0.011421740055084229,
0.00958008598536253,
-0.0007603358244523406,
-0.011584409512579441,
0.00799405574798584,
-0.018718639388680458,
-0.01264176331460476,
-0.04227089509367943,
0.0003017378621734679,
-0.01668526791036129,
-0.013269203715026379,
-0.02423779107630253,
0.013780451379716396,
-0.0015351957408711314,
-0.033440250903367996,
-0.02341282367706299,
0.01616240106523037,
-0.0006238094065338373,
-0.010137811303138733,
0.009144363924860954,
-0.04719746485352516,
-0.0013057151809334755,
0.018579209223389626,
-0.005728298798203468,
0.001933155581355095,
0.03462541848421097,
-0.007360805757343769,
-0.011299737729132175,
0.012792813591659069,
0.00513862119987607,
-0.00774424197152257,
-0.019311223179101944,
-0.04880092293024063,
0.012885767966508865,
-0.037135180085897446,
0.009893806651234627,
0.01005647610872984,
-0.0010922111105173826,
-0.014291699044406414,
-0.007308519445359707,
0.02350577898323536,
0.005353577435016632,
-0.02507437951862812,
-0.010091333650052547,
0.004641897510737181,
-0.00040050162351690233,
0.044687703251838684,
-0.018009863793849945,
-0.05121773108839989,
0.029605893418192863,
0.004333986900746822,
0.005742822773754597,
-0.0025344528257846832,
0.006042018998414278,
-0.03980761021375656,
-0.014036075212061405,
-0.004499561153352261,
0.0007258410914801061,
-0.01728947088122368,
-0.00297743733972311,
0.013861785642802715,
-0.003692022291943431,
0.052937380969524384,
0.008453017100691795,
0.017196515575051308,
-0.001190248760394752,
-0.029954470694065094,
0.0006877153646200895,
0.025562388822436333,
0.009074647910892963,
0.025469433516263962,
0.0016586504643782973,
-0.022274136543273926,
-0.016046209260821342,
-0.013559685088694096,
0.012862528674304485,
-0.011857462115585804,
-0.036438021808862686,
0.00715746870264411,
0.03253394737839699,
-0.018648924306035042,
-0.0033173009287565947,
0.00927798543125391,
0.01820739172399044,
0.010608390904963017,
-0.0012824767036363482,
-0.015244479291141033,
-0.0005079798283986747,
-0.013478349894285202,
-0.01942741498351097,
0.00927798543125391,
-0.006541647482663393,
0.03611268475651741,
0.010341147892177105,
0.027886241674423218,
-0.028606636449694633,
0.035996489226818085,
0.01638316735625267,
0.019543608650565147,
-0.013118152506649494,
-0.02393569052219391,
0.025353241711854935,
0.005615010857582092,
-0.03151145204901695,
0.019717896357178688,
0.02168155275285244,
-0.0011662839679047465,
-0.01830034703016281,
0.03583382070064545,
-0.019276365637779236,
-0.017754239961504936,
-0.015674391761422157,
0.0003676408960018307,
-0.015372291207313538,
0.0008438493241555989,
0.0036223067436367273,
0.013861785642802715,
-0.005795109551399946,
0.0013412991538643837,
0.0010864015202969313,
-0.0033608730882406235,
-0.010434102267026901,
0.009202459827065468,
-0.029791802167892456,
-0.01153793279081583,
-0.0004066743713337928,
-0.03462541848421097,
-0.05730622634291649,
0.001891035819426179,
0.03376559168100357,
-0.024516655132174492,
0.0035032092127949,
-0.008824833668768406,
-0.013664258643984795,
0.03811119869351387,
-0.04280538111925125,
-0.0008344086236320436,
0.03137202188372612,
0.007587381638586521,
-0.018544351682066917,
0.012258327566087246,
0.0067914617247879505,
0.02612011320888996,
-0.022181181237101555,
0.006663649808615446,
-0.021065732464194298,
-0.014651896432042122,
0.031232591718435287,
-0.01001580897718668,
0.014338175766170025,
0.010073904879391193,
-0.027839764952659607,
-0.0012919172877445817,
-0.00037689998862333596,
-0.007447950541973114,
0.044989801943302155,
-0.02828129753470421,
0.012560428120195866,
-0.01416388712823391,
0.026189828291535378,
-0.02542295679450035,
-0.004848139360547066,
0.00752928527072072,
0.02229737490415573,
-0.00899331271648407,
0.02442369982600212,
0.032743096351623535,
-0.013617781922221184,
-0.009893806651234627,
-0.014233602210879326,
0.028165103867650032,
0.00752928527072072,
-0.015128286555409431,
0.009243126958608627,
0.0005718858446925879,
-0.053123291581869125,
-0.013129772618412971,
-0.006907654460519552,
-0.021693171933293343,
-0.0010791394161060452,
0.02872282825410366,
-0.002088563283905387,
0.008505303412675858,
0.008563400246202946,
-0.01099182665348053,
-0.009713707491755486,
-0.018486253917217255,
0.001310072373598814,
-0.019659800454974174,
0.0009731136378832161,
0.0010667940368875861,
-0.022192800417542458,
-0.009399987757205963,
-0.005527866538614035,
-0.028908737003803253,
0.016894415020942688,
-0.006111734546720982,
0.005324529483914375,
-0.01383854728192091,
0.0173824243247509,
-0.02237870916724205,
0.04889387637376785,
-0.03636830672621727,
0.03546200320124626,
-0.003782071638852358,
-0.03218537196516991,
-0.038390059024095535,
0.013397015631198883,
-0.02072877250611782,
0.012781194411218166,
-0.06218631938099861,
0.012397758662700653,
0.02242518588900566,
-0.001108913798816502,
0.009824090637266636,
0.022320613265037537,
0.013245965354144573,
0.011032494716346264,
-0.04380463808774948,
-0.019392557442188263,
-0.015279336832463741,
0.021879080682992935,
-0.006175640504807234,
-0.0029077217914164066,
0.003471256233751774,
-0.012095657177269459,
-0.00969046913087368,
-0.013501589186489582,
-0.026654599234461784,
-0.0070006088353693485,
-0.020519627258181572,
0.01807958073914051,
-0.018660543486475945,
-0.022913195192813873,
-0.0016891510458663106,
0.020403433591127396,
-0.04327015206217766,
0.015337432734668255,
0.011415930464863777,
0.00037435826379805803,
0.03683307766914368,
0.0469186007976532,
-0.016046209260821342,
0.018184153363108635,
0.009452274069190025,
0.019183410331606865,
-0.027863003313541412,
-0.001694960636086762,
0.018846452236175537,
-0.034950755536556244,
-0.005707965232431889,
0.023366346955299377,
0.002742147073149681,
-0.013582923449575901,
0.019915424287319183,
-0.013722354546189308,
0.008778356947004795,
0.01436141412705183,
-0.030535435304045677,
0.021925557404756546,
-0.012955483049154282,
0.02337796613574028,
0.005835777148604393,
-0.006832129321992397,
-0.050520576536655426,
0.03011714108288288,
-0.007604810409247875,
-0.004095791839063168,
0.00906302873045206,
-0.00004259641718817875,
0.0032301563769578934,
0.02223927713930607,
0.0068669868633151054,
0.00615821173414588,
0.03859920799732208,
0.00920826941728592,
-0.00143352709710598,
0.027746811509132385,
-0.026445452123880386,
-0.003575829556211829,
0.03548524156212807,
-0.018718639388680458,
0.0043775588274002075,
0.005350672639906406,
0.009748565033078194,
0.007784909103065729,
0.033393774181604385,
0.014953996986150742,
-0.019055599346756935,
-0.011555361561477184,
-0.03436979278922081,
0.012746336869895458,
-0.028351012617349625,
0.008081200532615185,
0.1342257708311081,
-0.020089713856577873,
0.019171791151165962,
0.021623456850647926,
0.01576734520494938,
-0.022657571360468864,
0.007877863012254238,
0.0010515437461435795,
0.004325272515416145,
-0.0033202057238668203,
0.015267717652022839,
0.039133694022893906,
0.032138895243406296,
0.044385600835084915,
0.03715841844677925,
-0.024516655132174492,
0.008563400246202946,
0.04722070321440697,
-0.008191583678126335,
-0.0036455451045185328,
0.00995190255343914,
0.0206358190625906,
-0.013048437424004078,
-0.00019026550580747426,
0.01084077637642622,
-0.004363034851849079,
-0.006727555766701698,
-0.014884281903505325,
-0.0048771873116493225,
-0.002380497520789504,
0.01912531442940235,
-0.0035322573967278004,
0.012781194411218166,
-0.021402690559625626,
-0.01221184991300106,
-0.020659057423472404,
-0.040690675377845764,
0.0012882862938567996,
0.023738162592053413,
-0.0026651695370674133,
0.019613323733210564,
0.010823347605764866,
-0.0031226780265569687,
0.011038304306566715,
0.025608865544199944,
-0.0009295414201915264,
-0.02507437951862812,
-0.01733594760298729,
0.003299871925264597,
-0.03325434401631355,
0.014094171114265919,
-0.006495170295238495,
-0.00011882516264449805,
-0.029512939974665642,
-0.03557819873094559,
-0.02962913177907467,
-0.001216392032802105,
0.012525570578873158,
-0.023389585316181183,
-0.03348672762513161,
-0.021402690559625626,
0.009876376949250698,
0.032348040491342545,
-0.0036862127017229795,
0.01842815801501274
] | 2024-12-30 | 48 | 39735543 | [
"B cell malignancies",
"TROP2 CAR",
"myeloid cells",
"CAR expression",
"chimeric antigen receptor",
"flow cytometry",
"CAR",
"TROP2",
"functional activity",
"myeloid-specific cell activation",
"a TROP2 specific single-chain variable fragment",
"enzyme-linked immunosorbent assay",
"ELISA",
"association",
"FcRγ",
"scFv",
"immunoprecipitation",
"myeloid",
"adapter",
"the TROP2 CAR",
"-",
"Co",
"LNPs",
"a truncated CD89",
"the FcRγ signal",
"numerous \nThe CAR",
"These findings",
"the development",
"the treatment",
"The approval"
] | [
"RNA therapeutics",
"cancer therapy",
"cell therapy",
"lipid nanoparticles",
"myeloid cells"
] | 0 | 10.3389/fimmu.2024.1501365
10.1084/jem.20080421
10.1126/science.1178331
10.1084/jem.20141836
10.1038/nature10138
10.1038/s41573-022-00520-5
10.1097/00002371-200011000-00009
10.1007/bf01756597
10.1097/00002371-199507000-00003
10.1016/j.cell.2021.02.048
10.1126/scitranslmed.3006353
10.1038/gt.2012.61
10.4161/onci.28696
10.1200/jco.2023.41.16_suppl.tps2666
10.1080/14760584.2022.2042257
10.1038/nbt0918-777
10.1038/s41586-023-06063-y
10.1016/s0140-6736(23)02268-7
10.1016/j.celrep.2019.03.062
10.4049/jimmunol.166.1.346
10.1038/s41586-020-03144-0
10.1080/2162402x.2017.1380142
10.1136/jitc-2022-005447
10.1158/1078-0432.ccr-20-3119
10.1016/j.imlet.2014.02.005
10.1007/978-1-62703-260-5_3
10.18632/oncotarget.25615
10.1080/14712598.2020.1757067
10.1038/s41587-020-0462-y
10.1074/jbc.270.50.29781
10.1182/blood.v87.9.3593.bloodjournal8793593
10.1073/pnas.0915174107
10.1111/j.1365-2249.2007.03407.x
10.4049/jimmunol.179.5.2918
10.4049/jimmunol.168.1.102
10.1016/j.intimp.2024.111631
10.1007/s00432-022-04017-x
10.1056/nejmoa1610497
10.1056/nejmc2305296
10.1038/s41591-023-02452-y
10.1158/2159-8290.cd-21-0407
10.1038/s41591-022-01800-8
10.1038/s41408-021-00459-7
10.1038/s41571-023-00832-4
10.1200/jco.2024.42.16_suppl.2543
10.1158/0008-5472.can-16-1831
10.1158/2326-6066.cir-19-0734
10.1136/jitc-2020-001356
10.1136/jitc-2020-001202 | [
"Argueta",
"Wang",
"Zhao",
"Diwanji",
"Gorgievski",
"Cochran",
"Grudzien-Nogalska",
"D'Alessandro",
"McCreedy",
"Prod'homme",
"Hofmeister",
"Ding",
"Getts"
] | [
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States.",
"Myeloid Therapeutics, Inc., Cambridge, MA, United States."
] | [
"39735543",
"18779347",
"20133564",
"26056232",
"21654748",
"35974096",
"1701343",
"11186156",
"1651160",
"8535567",
"33765443",
"24382895",
"22895508",
"25097805",
"35157542",
"30188543",
"37165196",
"38246194",
"30995475",
"11123311",
"33536615",
"29296544",
"36460336",
"33168656",
"24613852",
"23296926",
"29989029",
"32301634",
"32361713",
"8530370",
"8611682",
"20160101",
"17488293",
"17709506",
"11751952",
"38359664",
"35445870",
"28029927",
"37314725",
"37501016",
"34266984",
"35534566",
"33824268",
"37904019",
"28082401",
"32019780",
"33115946",
"33122397"
] | [] | 8.123181 | 4.755754 |
|
39734708 | 92 | Severe refractory colitis after intraperitoneal infusion of CEA-directed CAR T cells in patients with colorectal cancer. | Chimeric antigen receptor T (CAR T) cells have shown their potential in hematological malignancies and the treatment of solid tumors, especially in metastases. However, CAR T-cell therapy may carry risks of inducing severe adverse effects, which are recognized as immune-related adverse events. Here, we report two cases of severe colitis presented with refractory bloody diarrhea, which were induced by carcinoembryonic antigen (CEA)-directed CAR T therapy in the treatment of metastatic colorectal adenocarcinoma. These patients were treated as part of a clinical trial. The clinical trial was registered at ClinicalTrials.gov (NCT05396300), submitted, and started on May 25, 2022. Glucocorticoids combined with vedolizumab were used to control their gastrointestinal symptoms but the outcomes were unsatisfactory. This report highlights the potentially serious risks of anti-CEA CAR T therapy and provides management options.
Serious bowel inflammation following novel cancer therapy in colon cancer patients A recent approach for treating cancer, especially in advanced stages where it has spread, uses a type of therapy involving modified immune cells, known as CAR T cell therapy. While it can be very effective, this treatment sometimes causes serious side effects. We discuss two cases where patients experienced severe inflammation of the colon with intense diarrhea after receiving this treatment. They were treated with common medications to reduce inflammation, but unfortunately, these did not work well. Subsequently, a series of complications occurred. Our report highlight the possible risks of this therapy and discuss possible mechanisms. | [
0.037861596792936325,
0.05367965251207352,
0.073155477643013,
0.07354305684566498,
-0.0680200606584549,
-0.00015840008563827723,
0.014207182452082634,
-0.0030188746750354767,
0.004702419973909855,
0.008133096620440483,
-0.002697911113500595,
-0.04062309488654137,
-0.02732429839670658,
0.004505602642893791,
0.03449450433254242,
-0.03258083388209343,
0.06574303656816483,
0.006867410149425268,
-0.003041584510356188,
0.05445480719208717,
0.02022676356136799,
0.022746024653315544,
0.004193722736090422,
0.03846718743443489,
-0.02771187759935856,
-0.020129868760704994,
-0.019572725519537926,
-0.014304076321423054,
-0.004454127047210932,
-0.03585103154182434,
0.060704514384269714,
-0.01391649805009365,
-0.012935439124703407,
-0.025677088648080826,
-0.005386738572269678,
0.026040444150567055,
0.04505602642893791,
0.00834505446255207,
-0.019899744540452957,
-0.02315782755613327,
-0.004932544659823179,
0.02521684020757675,
0.0020105645526200533,
0.1044524610042572,
-0.07257411628961563,
-0.007327659986913204,
0.005338291171938181,
-0.04961007460951805,
0.014182958751916885,
-0.012008883990347385,
-0.03495475649833679,
0.0035820750053972006,
-0.007436666637659073,
0.03807960823178291,
-0.03696531802415848,
0.013189787976443768,
-0.03904855623841286,
0.03539077937602997,
-0.0025132056325674057,
-0.019730178639292717,
-0.009077819995582104,
-0.022758137434720993,
0.006443495862185955,
-0.02853548154234886,
-0.04224608093500137,
-0.03602059558033943,
-0.025919325649738312,
-0.008084649220108986,
0.009949872270226479,
-0.0010847662342712283,
0.01671433262526989,
0.004672140348702669,
-0.009901424869894981,
0.034930530935525894,
0.04423242062330246,
-0.028608152642846107,
0.010404066182672977,
0.02698516845703125,
-0.006788683123886585,
-0.037885818630456924,
0.025386406108736992,
0.019911855459213257,
-0.021014032885432243,
-0.026936721056699753,
-0.0036971375811845064,
0.01756216026842594,
-0.028317470103502274,
-0.04980386421084404,
-0.013323018327355385,
0.0015488008502870798,
-0.037013765424489975,
-0.00556538812816143,
-0.030037349089980125,
0.040162842720746994,
0.0029658854473382235,
0.01498233899474144,
-0.009792418219149113,
-0.05489083379507065,
0.0469939187169075,
0.0540187805891037,
0.044813789427280426,
0.03759513422846794,
-0.010004375129938126,
-0.004230058286339045,
0.08076171576976776,
0.015091345645487309,
-0.04495913162827492,
-0.005047607235610485,
0.051111940294504166,
-0.0347609668970108,
0.09684623032808304,
0.001904585980810225,
-0.01880967989563942,
0.029843561351299286,
-0.017501601949334145,
-0.0015465299366042018,
-0.05140262469649315,
-0.011270062066614628,
0.001249789958819747,
0.037328675389289856,
-0.04905293136835098,
0.03432494029402733,
0.034591399133205414,
-0.03376779332756996,
-0.015600043348968029,
-0.014849109575152397,
0.051983993500471115,
-0.02349695935845375,
-0.031636111438274384,
-0.07504492998123169,
0.03207213804125786,
0.012269288301467896,
0.03725600242614746,
0.012226897291839123,
-0.07155671715736389,
0.0018970160745084286,
-0.023218387737870216,
0.004230058286339045,
-0.03294419124722481,
-0.004087744280695915,
0.01377115584909916,
-0.014836997725069523,
0.007206541486084461,
-0.03725600242614746,
-0.02055378258228302,
-0.058088358491659164,
-0.009465399198234081,
0.025895101949572563,
0.031757231801748276,
0.012935439124703407,
-0.015478924848139286,
0.08933689445257187,
0.09175925701856613,
0.008242103271186352,
0.013214011676609516,
-0.03512432053685188,
0.00904148444533348,
0.031054744496941566,
-0.023242611438035965,
-0.043118130415678024,
0.001053729560226202,
-0.016823338344693184,
-0.027396969497203827,
-0.027421193197369576,
0.03277462348341942,
-0.026258457452058792,
-0.015018674544990063,
0.03711066022515297,
-0.04018706828355789,
-0.0047357273288071156,
-0.008290550671517849,
-0.03447028249502182,
-0.07097534835338593,
-0.026936721056699753,
-0.0697157233953476,
-0.019209370017051697,
0.02245534211397171,
0.0059136031195521355,
0.01569693721830845,
0.002719106851145625,
0.00032380232005380094,
0.029359087347984314,
-0.013504695147275925,
0.017973963171243668,
-0.03643240034580231,
0.018070857971906662,
-0.022019315510988235,
0.02751808799803257,
-0.05242002010345459,
-0.0028947284445166588,
0.028826165944337845,
-0.013117116875946522,
0.031030520796775818,
0.008938534185290337,
-0.03187834843993187,
-0.041882723569869995,
0.02490193210542202,
0.0036698859184980392,
-0.043820615857839584,
-0.01211183425039053,
0.03468829393386841,
-0.04672745615243912,
-0.0488106943666935,
0.023775530979037285,
0.0017940654652193189,
-0.043772172182798386,
0.0014314674772322178,
0.04391751065850258,
0.005595667753368616,
0.00975002720952034,
0.045855406671762466,
-0.0023663497995585203,
-0.018361540511250496,
0.02072334848344326,
-0.03323487564921379,
-0.01366214919835329,
-0.0019757431000471115,
0.027082061395049095,
0.0609951987862587,
0.0006052132230252028,
0.01862800121307373,
0.02125626988708973,
0.01774383708834648,
0.008042258210480213,
-0.05949333310127258,
-0.008423781022429466,
-0.02316994033753872,
0.003318642731755972,
-0.003933318424969912,
0.0012641727225854993,
-0.01688389666378498,
0.007818189449608326,
0.0505305752158165,
-0.028244799003005028,
-0.001971201039850712,
-0.0418100543320179,
0.023714972659945488,
0.011360900476574898,
0.06322377920150757,
-0.0007206541486084461,
0.029334863647818565,
0.014776438474655151,
0.002984053222462535,
-0.030715612694621086,
-0.039969053119421005,
-0.0020272182300686836,
0.012287456542253494,
-0.06986106187105179,
0.024441681802272797,
0.03807960823178291,
-0.018664337694644928,
0.04164048656821251,
0.003663829993456602,
-0.020832356065511703,
0.006049861200153828,
0.00596810644492507,
0.025507524609565735,
-0.046218760311603546,
0.013637925498187542,
-0.038903214037418365,
0.04556472226977348,
0.002723648911342025,
-0.03783737123012543,
-0.02994045428931713,
-0.032992638647556305,
0.01070080604404211,
0.009356392547488213,
-0.009441175498068333,
-0.0032944190315902233,
0.0008160348515957594,
0.030037349089980125,
0.0037092494312673807,
0.028172127902507782,
0.017973963171243668,
-0.0234848465770483,
0.019887631759047508,
0.008357166312634945,
0.01532147079706192,
-0.014473642222583294,
0.03255661204457283,
-0.009295833297073841,
-0.006174007896333933,
-0.03255661204457283,
-0.04164048656821251,
-0.010519128292798996,
-0.008823471143841743,
0.012305623851716518,
0.00279026385396719,
-0.016266193240880966,
-0.0074608903378248215,
0.01930626481771469,
0.018567442893981934,
0.007279212586581707,
-0.006249706726521254,
-0.040138620883226395,
0.015273023396730423,
-0.0037910041864961386,
0.0017986074090003967,
-0.02246745303273201,
-0.004236114211380482,
-0.045177143067121506,
0.035802584141492844,
-0.004220974165946245,
-0.0003947701188735664,
0.04023551568388939,
-0.0019893688149750233,
-0.006837130524218082,
-0.003824311774224043,
-0.003672913881018758,
0.04263365641236305,
-0.0024329647421836853,
-0.019887631759047508,
0.023618077859282494,
0.06031693518161774,
0.03398580849170685,
-0.02022676356136799,
0.02562864124774933,
-0.04287589341402054,
0.013553142547607422,
-0.015442589297890663,
-0.023557517677545547,
-0.0070430319756269455,
-0.022939814254641533,
0.010755308903753757,
0.006952193100005388,
-0.04340881481766701,
0.02768765389919281,
-0.006255762651562691,
0.003921206574887037,
-0.009447230957448483,
-0.004575245548039675,
-0.026912497356534004,
0.05096660181879997,
-0.014703767374157906,
0.03820072486996651,
-0.021026145666837692,
0.007509337272495031,
-0.056005124002695084,
0.051838651299476624,
-0.014970227144658566,
0.02839014120399952,
0.042778998613357544,
-0.024429570883512497,
0.058233700692653656,
-0.007715238723903894,
0.004420819692313671,
-0.012160281650722027,
0.0016941428184509277,
-0.0002833033795468509,
0.01792551577091217,
-0.03812805563211441,
0.006279986351728439,
-0.0017970934277400374,
0.03938768804073334,
-0.009477511048316956,
0.018882350996136665,
-0.05716785788536072,
0.0015730245504528284,
0.035947926342487335,
0.00430272938683629,
0.010349562391638756,
0.034712519496679306,
-0.0348578616976738,
0.05082125961780548,
0.05188709869980812,
0.04280322417616844,
-0.039436131715774536,
0.055472202599048615,
-0.008423781022429466,
-0.0366019643843174,
0.0018137472216039896,
-0.008653906174004078,
0.0048568458296358585,
-0.0032217479310929775,
-0.031078968197107315,
0.03737712278962135,
0.000007451616966136498,
0.018603777512907982,
0.03100629709661007,
0.012341959401965141,
0.036819975823163986,
-0.023969320580363274,
-0.004738755524158478,
-0.03793426603078842,
-0.00735793961212039,
0.049367837607860565,
-0.0023360701743513346,
-0.011233726516366005,
-0.027808772400021553,
0.02509572170674801,
-0.0076183439232409,
-0.01969384402036667,
0.0007024864316917956,
0.004323924891650677,
-0.01951216533780098,
0.09563504904508591,
-0.01774383708834648,
0.07092690467834473,
0.04827777296304703,
-0.012765874154865742,
0.029698219150304794,
-0.03674730658531189,
-0.018870238214731216,
-0.053001388907432556,
0.031442321836948395,
-0.0019318376434966922,
0.04999765381217003,
0.001239192089997232,
0.001429196447134018,
-0.031103191897273064,
-0.009865089319646358,
-0.012154226191341877,
0.04367527738213539,
0.02715473249554634,
-0.004030212759971619,
-0.026088891550898552,
-0.022079873830080032,
0.04142247512936592,
-0.03255661204457283,
0.040162842720746994,
0.07678902894258499,
-0.027469640597701073,
0.01636308804154396,
-0.0010242069838568568,
-0.002186186145991087,
0.006588838063180447,
-0.004290617536753416,
-0.003715305356308818,
-0.010827980004251003,
-0.03887898847460747,
-0.027300074696540833,
0.057555437088012695,
-0.0296013243496418,
0.0009477510466240346,
0.026064667850732803,
0.01847054809331894,
-0.009895368479192257,
0.004938600584864616,
-0.06729335337877274,
0.020844466984272003,
-0.06545235216617584,
0.011094440706074238,
0.02072334848344326,
-0.021316828206181526,
0.053728099912405014,
-0.03168455883860588,
0.042439866811037064,
0.03570568934082985,
-0.038394514471292496,
-0.029213745146989822,
-0.0012777985539287329,
-0.022661242634058,
-0.021680183708667755,
0.020590119063854218,
-0.036311279982328415,
-0.00012897211126983166,
0.010779532603919506,
-0.08265116065740585,
-0.01880967989563942,
0.020081421360373497,
0.029359087347984314,
-0.03902433067560196,
-0.00021895926329307258,
-0.00861151423305273,
0.0022800529841333628,
0.010161829181015491,
0.013843826949596405,
0.0022679411340504885,
-0.001638125628232956,
-0.035778358578681946,
-0.0067039006389677525,
-0.0008258757297880948,
-0.018906574696302414,
-0.0006021852605044842,
-0.0007834843127056956,
0.017998186871409416,
-0.005105138290673494,
-0.01878545619547367,
0.003866703249514103,
0.012729538604617119,
0.009895368479192257,
0.015769608318805695,
-0.004030212759971619,
-0.002697911113500595,
0.05193554610013962,
0.008799247443675995,
-0.04445043206214905,
0.008732632733881474,
-0.004862901754677296,
0.03166033700108528,
-0.006304210051894188,
0.01124583836644888,
0.017864955589175224,
-0.011360900476574898,
-0.0052323127165436745,
-0.0023618077393621206,
0.005141473840922117,
-0.025507524609565735,
-0.002034788252785802,
-0.001863708603195846,
0.024453794583678246,
-0.01035561878234148,
0.004384484142065048,
0.014388859272003174,
0.050772812217473984,
0.031030520796775818,
0.0038848710246384144,
0.0609951987862587,
0.03146654739975929,
0.021534841507673264,
-0.029116850346326828,
0.005432157777249813,
0.05639270320534706,
-0.005813680589199066,
-0.039969053119421005,
-0.030764060094952583,
-0.036626186221838,
-0.0066251736134290695,
-0.00430272938683629,
0.0018788482993841171,
0.0008652391843497753,
-0.005314067471772432,
0.010192109271883965,
-0.013044445775449276,
0.020989809185266495,
-0.03015846759080887,
-0.02560441754758358,
0.0014178416458889842,
-0.01158497016876936,
-0.029892008751630783,
0.018664337694644928,
-0.020275210961699486,
0.010228443890810013,
0.01411028765141964,
-0.03180567920207977,
0.006316321901977062,
-0.012681091204285622,
0.0200208630412817,
-0.024647584185004234,
-0.035293884575366974,
0.006716012489050627,
-0.01896713301539421,
0.030061572790145874,
-0.01602395810186863,
0.018070857971906662,
0.0234848465770483,
0.010991489514708519,
-0.002181644318625331,
0.030570270493626595,
0.0018031493527814746,
0.02281869575381279,
-0.041034895926713943,
0.0191730335354805,
0.010058878920972347,
0.024478018283843994,
0.006564614363014698,
-0.012899103574454784,
-0.05411567538976669,
-0.02469603158533573,
0.010040710680186749,
-0.017634831368923187,
-0.03064294159412384,
0.007224709261208773,
-0.042221855372190475,
-0.03296841308474541,
0.021510617807507515,
-0.012172393500804901,
-0.013843826949596405,
-0.04488645866513252,
0.030691388994455338,
-0.04161626473069191,
0.008920365944504738,
-0.008242103271186352,
-0.002255829283967614,
0.04052620008587837,
0.006340545602142811,
0.0050082434900105,
0.024150997400283813,
-0.008127041161060333,
-0.005716785788536072,
-0.02560441754758358,
-0.00818154402077198,
-0.007006696425378323,
0.040283963084220886,
0.0016366116469725966,
0.02245534211397171,
0.0078000216744840145,
-0.006161896046251059,
-0.007739462424069643,
-0.024611247703433037,
0.03323487564921379,
0.01383171509951353,
0.0382976196706295,
0.006613061763346195,
0.00556538812816143,
0.007351883687078953,
0.010216332040727139,
-0.01035561878234148,
-0.007158094085752964,
0.020069310441613197,
0.006697844713926315,
-0.024465905502438545,
-0.02754231169819832,
-0.03599637374281883,
-0.01331090647727251,
0.02858392894268036,
0.007709182798862457,
0.0025858767330646515,
0.03149076923727989,
0.0060347216203808784,
0.025846654549241066,
0.03357400372624397,
-0.035778358578681946,
0.012765874154865742,
0.02836591750383377,
0.009562293067574501,
-0.016060292720794678,
-0.02455068938434124,
0.025386406108736992,
-0.00791508425027132,
0.014812774024903774,
0.0020998893305659294,
0.010264779441058636,
-0.02232211083173752,
-0.009798474609851837,
-0.03747401759028435,
-0.023048821836709976,
0.016072403639554977,
0.010670525953173637,
-0.0007119487854652107,
-0.012947550974786282,
-0.033355992287397385,
-0.002984053222462535,
0.04944051057100296,
-0.004463211167603731,
-0.013601589947938919,
0.028462810441851616,
-0.004535882268100977,
-0.04350570961833,
0.00007451616693288088,
0.004732699599117041,
0.0065827821381390095,
0.0027160788886249065,
-0.028632376343011856,
0.010416178032755852,
-0.0104404017329216,
0.004635804798454046,
-0.0007395789143629372,
-0.004093800205737352,
-0.005644115153700113,
0.002263399073854089,
-0.013129228726029396,
-0.009489621967077255,
-0.02124415710568428,
0.01549103669822216,
-0.0012293512700125575,
0.0108945956453681,
0.009314000606536865,
0.05159641429781914,
0.06075296178460121,
0.008078593760728836,
0.02698516845703125,
-0.030352257192134857,
-0.026694484055042267,
-0.02509572170674801,
0.017186693847179413,
-0.004293645266443491,
-0.0034034254495054483,
-0.009307945147156715,
0.011627361178398132,
0.09515057504177094,
0.01540625374764204,
-0.0075577846728265285,
0.0019545473624020815,
0.0032641394063830376,
0.017889179289340973,
0.02909262664616108,
-0.01122161466628313,
-0.0026888272259384394,
0.013601589947938919,
-0.030691388994455338,
0.019051915034651756,
-0.027469640597701073,
-0.059444885700941086,
-0.003032500622794032,
-0.00008610757504357025,
0.00045797874918207526,
0.03044915199279785,
0.015127681195735931,
0.015091345645487309,
0.007763686124235392,
-0.012184505350887775,
-0.0348094142973423,
0.0173804834485054,
-0.011233726516366005,
0.020929250866174698,
0.0068007949739694595,
-0.03669885918498039,
-0.0043511767871677876,
-0.0036880536936223507,
0.026379575952887535,
0.027808772400021553,
0.03904855623841286,
-0.008508563973009586,
0.03565724194049835,
-0.027106285095214844,
0.01202099584043026,
-0.039823710918426514,
0.029892008751630783,
0.03725600242614746,
0.005889379419386387,
0.006649397313594818,
-0.014921780675649643,
-0.013020222075283527,
-0.03921812027692795,
0.007872692309319973,
-0.00548060517758131,
0.030957849696278572,
0.004675168078392744,
0.036989543586969376,
0.02472025528550148,
0.02943175844848156,
-0.016750667244195938,
-0.01113683171570301,
0.009707635268568993,
0.02419944480061531,
0.005898463539779186,
0.04793864116072655,
-0.0012952092802152038,
-0.014740102924406528,
0.0021740742959082127,
-0.05028833821415901,
-0.013298794627189636,
0.0022406894713640213,
-0.034930530935525894,
0.025313735008239746,
-0.03970259428024292,
-0.022564347833395004,
0.003803116036579013,
0.014921780675649643,
0.03987215831875801,
-0.025119945406913757,
-0.02771187759935856,
0.009368504397571087,
-0.008835582993924618,
0.023448511958122253,
0.0252410639077425,
0.012396463192999363,
-0.029552876949310303,
-0.01201494038105011,
0.02074757218360901,
0.009005148895084858,
-0.0026418939232826233,
-0.013262459076941013,
0.0025026078801602125,
-0.04115601256489754,
0.0031127415131777525,
0.013698484748601913,
-0.030885178595781326,
-0.004490462597459555,
0.023073045536875725,
0.010113381780683994,
0.007878748700022697,
0.016254082322120667,
-0.00189398811198771,
0.014061840251088142,
0.018555330112576485,
0.02596777305006981,
-0.016472095623612404,
0.032120585441589355,
-0.02021465264260769,
-0.03408270329236984,
0.012717426754534245,
0.00871446542441845,
0.018664337694644928,
0.011039936915040016,
-0.04653367027640343,
0.00374558474868536,
-0.03430071473121643,
0.02664603665471077,
0.01705346256494522,
0.03696531802415848,
-0.02054167166352272,
0.029359087347984314,
0.010507016442716122,
-0.00440265191718936,
-0.009271609596908092,
-0.00723076518625021,
-0.0156606025993824,
-0.018409987911581993,
-0.01672644354403019,
0.007654679473489523,
-0.0330653078854084,
-0.005843960214406252,
-0.007909027859568596,
0.04035663232207298,
0.029867785051465034,
-0.07175050675868988,
-0.031200086697936058,
0.008623626083135605,
0.011021769605576992,
-0.000033118296414613724,
0.016750667244195938,
-0.003173300763592124,
-0.017029238864779472,
0.03173300623893738,
-0.03338021785020828,
0.027736101299524307,
-0.037183333188295364,
0.027566535398364067,
-0.03367089852690697,
-0.017295699566602707,
-0.0012823404977098107,
-0.0014799147611483932,
-0.04827777296304703,
-0.004348148591816425,
0.030570270493626595,
0.00904148444533348,
0.030521823093295097,
0.0005931013729423285,
0.04735727235674858,
0.012239009141921997,
0.0082663269713521,
-0.01983918435871601,
-0.02574975974857807,
-0.006691788788884878,
-0.039629921317100525,
0.012584196403622627,
0.01759849488735199,
-0.00923527404665947,
0.017804397270083427,
0.010834036394953728,
-0.036311279982328415,
0.01156680192798376,
0.013456248678267002,
-0.01062207855284214,
0.0017501601250842214,
0.0028765606693923473,
0.029334863647818565,
0.021655960008502007,
0.0347851887345314,
-0.031054744496941566,
0.008884030394256115,
-0.033186428248882294,
0.004336036741733551,
-0.03100629709661007,
-0.02645224705338478,
0.012287456542253494,
-0.021668072789907455,
-0.009386671707034111,
-0.013468360528349876,
-0.0031551329884678125,
0.0023406120017170906,
0.00005469250390888192,
0.0027932918164879084,
-0.006025637499988079,
-0.000041114002669928595,
-0.031587664037942886,
0.018724896013736725,
0.018567442893981934,
-0.015745384618639946,
0.017368370667099953,
-0.020335771143436432,
-0.031611889600753784,
0.020444776862859726,
-0.049004483968019485,
-0.005020355340093374,
0.015212464146316051,
-0.011748479679226875,
-0.02749386429786682,
0.020590119063854218,
-0.026742931455373764,
-0.006455607712268829,
-0.015709049999713898,
0.00941089540719986,
-0.00809676107019186,
0.008084649220108986,
-0.00958651676774025,
-0.02332739345729351,
-0.001742590218782425,
0.00880530383437872,
-0.017465265467762947,
0.0062436508014798164,
-0.0062860422767698765,
0.043263472616672516,
-0.022891366854310036,
-0.014073952101171017,
-0.0026206981856375933,
0.0009280693484470248,
-0.012681091204285622,
-0.0013232178753241897,
-0.0017017127247527242,
0.00289624254219234,
-0.02143794670701027,
0.013977057300508022,
0.02562864124774933,
-0.018397876992821693,
0.02037210576236248,
-0.030570270493626595,
-0.01638731174170971,
-0.03146654739975929,
-0.004787202458828688,
-0.009641020558774471,
0.04367527738213539,
0.00452074222266674,
0.014061840251088142,
-0.023920873180031776,
0.022346334531903267,
-0.01463109627366066,
0.02280658483505249,
-0.02771187759935856,
0.023896649479866028,
-0.0059469109401106834,
-0.012323792092502117,
-0.0061649237759411335,
0.042924340814352036,
0.010761365294456482,
0.057749226689338684,
0.019923968240618706,
0.004093800205737352,
-0.023727083578705788,
-0.0007312520174309611,
-0.009743970818817616,
0.034397609531879425,
-0.001836456940509379,
0.017029238864779472,
-0.0030930598732084036,
0.01009521447122097,
0.012075498700141907,
0.03338021785020828,
0.014449418522417545,
0.010119438171386719,
0.03180567920207977,
0.03417959809303284,
0.016799114644527435,
0.017017127946019173,
0.021014032885432243,
-0.007370051462203264,
-0.028002562001347542,
0.015963397920131683,
-0.025192616507411003,
0.027736101299524307,
-0.017126133665442467,
-0.05973557010293007,
0.0028977564070373774,
0.0037910041864961386,
0.04130135476589203,
-0.03396158292889595,
0.01253574900329113,
0.012826432473957539,
0.024829261004924774,
0.013722708448767662,
0.037716254591941833,
0.01454631332308054,
-0.023254722356796265,
-0.02734852209687233,
-0.035075873136520386,
-0.016314640641212463,
0.03570568934082985,
-0.041034895926713943,
-0.010373786091804504,
0.03168455883860588,
-0.012317735701799393,
-0.0003678969806060195,
0.004599469248205423,
0.013238235376775265,
0.013214011676609516,
-0.00770312687382102,
-0.05028833821415901,
0.037328675389289856,
-0.012693203054368496,
-0.01791340298950672,
0.00009429252531845123,
-0.006152811925858259,
-0.011191335506737232,
0.02785721980035305,
0.029044179245829582,
-0.040138620883226395,
0.005550248082727194,
0.016084516420960426,
0.008242103271186352,
0.00513541791588068,
-0.01618141122162342,
0.002358779776841402,
-0.05358275771141052,
0.01689600944519043,
-0.01167580857872963,
-0.013964945450425148,
-0.02332739345729351,
0.004063520580530167,
0.031975243240594864,
0.01934259943664074,
-0.03354978188872337,
0.008950646035373211,
-0.007812133524566889,
-0.02751808799803257,
-0.026234233751893044,
-0.013759043999016285,
0.057216305285692215,
0.060510724782943726,
0.0036971375811845064,
-0.01761060766875744,
0.02909262664616108,
0.0191609226167202,
-0.04282744601368904,
-0.014849109575152397,
0.009525957517325878,
-0.018022410571575165,
0.030206914991140366,
-0.030618717893958092,
0.017550047487020493,
0.03066716529428959,
0.032798849046230316,
0.010428289882838726,
0.005041551310569048,
-0.052323125302791595,
-0.0052323127165436745,
-0.01585439220070839,
-0.041374027729034424,
0.00022709689801558852,
-0.004784174729138613,
-0.0049809920601546764,
0.01692023314535618,
0.016157187521457672,
0.031200086697936058,
-0.005410962272435427,
-0.000667664862703532,
-0.00923527404665947,
0.012547860853374004,
-0.007951419800519943,
0.00799986720085144,
0.016072403639554977,
0.016169298440217972,
-0.006631229538470507,
-0.01986340805888176,
0.023448511958122253,
-0.02301248535513878,
0.0452740378677845,
0.0012982372427359223,
0.00579248508438468,
-0.04454732686281204,
-0.06196414679288864,
-0.01669010892510414,
0.018942909315228462,
-0.01620563492178917,
0.011597082018852234,
-0.00757595244795084,
-0.017973963171243668,
-0.0068007949739694595,
0.035972148180007935,
0.042439866811037064,
0.039266567677259445,
-0.016338864341378212,
-0.010161829181015491,
0.013843826949596405,
0.018761232495307922,
0.02732429839670658,
-0.010597854852676392,
0.015273023396730423,
-0.013989169150590897,
-0.008986981585621834,
0.015055010095238686,
-0.009719747118651867,
-0.03706221282482147,
-0.0014806718099862337,
0.010906707495450974,
0.021655960008502007,
0.021752854809165,
0.025895101949572563,
-0.030400704592466354,
-0.0033519503194838762,
0.004672140348702669,
-0.00886586308479309,
0.004878041334450245,
-0.005192948970943689,
-0.00009400865383213386,
-0.011887765489518642,
0.003218719968572259,
-0.01115499995648861,
0.0017365342937409878,
0.0007195186917670071,
0.03359822928905487,
0.019391046836972237,
-0.013516806997358799,
-0.024974603205919266,
0.02035999484360218,
0.007981698960065842,
-0.028123680502176285,
0.005489688832312822,
0.0009795445948839188,
-0.0025510552804917097,
0.004251253791153431,
-0.04418397322297096,
0.003781920298933983,
-0.01219661720097065,
0.005677422508597374,
-0.0046479166485369205,
0.008877974934875965,
0.00701275235041976,
-0.004078660160303116,
0.004245197866111994,
0.02957710064947605,
-0.03449450433254242,
-0.000420129275880754,
-0.027033613994717598,
0.016956567764282227,
0.015951287001371384,
-0.06365980207920074,
0.028317470103502274,
0.02057800628244877,
-0.015115569345653057,
0.03241126984357834,
-0.01139723602682352,
-0.004454127047210932,
0.0348094142973423,
-0.010004375129938126,
0.006643341388553381,
-0.005268648266792297,
0.02819635160267353,
-0.0076365116983652115,
-0.03192679584026337,
-0.03384046629071236,
0.012584196403622627,
-0.006988528650254011,
-0.007860580459237099,
-0.005907547194510698,
-0.022176768630743027,
0.02452646568417549,
-0.03432494029402733,
0.004081688355654478,
0.017368370667099953,
0.04093800112605095,
-0.002908354392275214,
0.0013580394443124533,
-0.008078593760728836,
0.01690812036395073,
-0.0021634765435010195,
0.024296339601278305,
0.027736101299524307,
-0.007933251559734344,
0.009653132408857346,
0.009628908708691597,
-0.0006086197099648416,
-0.018700672313570976,
-0.04822932556271553,
-0.026936721056699753,
-0.018058745190501213,
0.06467719376087189,
0.0064616636373102665,
-0.04166471213102341,
0.05242002010345459,
0.04629143327474594,
-0.010549408383667469,
0.0036184105556458235,
0.024853484705090523,
0.005850016139447689,
0.004505602642893791,
0.0067039006389677525,
0.011530466377735138,
0.017816508188843727,
-0.009380616247653961,
0.029019955545663834,
0.013516806997358799,
-0.020335771143436432,
-0.022176768630743027,
0.005105138290673494,
-0.0008834069594740868,
-0.002699425211176276,
-0.021898197010159492,
-0.02526528760790825,
-0.010107326321303844,
0.017501601949334145,
0.025119945406913757,
0.0627877488732338,
0.006382937077432871,
-0.03340443968772888,
0.03413115069270134,
0.0234848465770483,
-0.02193453162908554,
-0.012923327274620533,
-0.011064160615205765,
-0.021171486005187035,
-0.011021769605576992,
-0.01670221984386444,
-0.02940753474831581,
-0.016084516420960426,
-0.005444269627332687,
0.02037210576236248,
-0.028341693803668022,
0.0020075365900993347,
-0.009683411568403244,
-0.02314571663737297,
-0.006855298299342394,
-0.020868690684437752,
-0.0009727317374199629,
-0.011809038929641247,
-0.006395048461854458,
-0.01987552084028721,
-0.02492615580558777,
0.008454060181975365,
-0.007987755350768566,
0.015890726819634438,
0.014425194822251797,
-0.002655519638210535,
0.0012747705914080143,
0.04096222296357155,
-0.005553276278078556,
-0.0062860422767698765,
0.01758638396859169,
-0.06414427608251572,
0.004641860723495483,
-0.01793762668967247,
0.012632643803954124,
0.01280220877379179,
-0.01655687764286995,
-0.027445416897535324,
-0.017901292070746422,
0.01210577879101038,
0.018942909315228462,
0.0044420151971280575,
0.0036456622183322906,
-0.00983481016010046,
0.007727350573986769,
0.0046479166485369205,
0.020432664081454277,
-0.03451872989535332,
0.018409987911581993,
0.00021384957653936,
0.01669010892510414,
0.006019582040607929,
-0.0018500827718526125,
-0.02732429839670658,
0.021982979029417038,
0.005229284521192312,
0.01671433262526989,
-0.0031642168760299683,
-0.021098816767334938,
0.008133096620440483,
0.007588064298033714,
0.034397609531879425,
0.005159641616046429,
0.0074608903378248215,
0.002819029614329338,
-0.00258890469558537,
0.0032066081184893847,
0.0382733978331089,
0.012814320623874664,
0.043772172182798386,
0.04784174636006355,
-0.03941190987825394,
-0.026331128552556038,
-0.0331137552857399,
0.004423847422003746,
-0.01847054809331894,
-0.022419005632400513,
0.0017335063312202692,
0.004532854072749615,
-0.0348820835351944,
-0.005035495385527611,
-0.017307812348008156,
-0.004136191681027412,
0.028002562001347542,
-0.006255762651562691,
0.0020983752328902483,
-0.03853985667228699,
0.005326179321855307,
0.001531390124000609,
-0.010628134943544865,
-0.0014693168923258781,
0.014037616550922394,
0.00575009360909462,
0.02457491308450699,
-0.021522730588912964,
0.028656600043177605,
-0.010500960983335972,
0.04304546117782593,
0.0010840091854333878,
-0.05382499471306801,
-0.002802375704050064,
0.014061840251088142,
-0.016472095623612404,
0.013492584228515625,
0.04999765381217003,
-0.031224310398101807,
0.004205834586173296,
0.032096363604068756,
-0.010725029744207859,
-0.009683411568403244,
-0.0036486901808530092,
-0.00862968247383833,
0.018737008795142174,
-0.01228140015155077,
-0.025846654549241066,
0.005165697541087866,
-0.030521823093295097,
-0.006752347573637962,
0.024780813604593277,
0.00757595244795084,
-0.007751574274152517,
-0.01670221984386444,
-0.019015580415725708,
0.026936721056699753,
-0.008381390012800694,
-0.05019144341349602,
-0.07640144973993301,
0.011621305719017982,
-0.022043539211153984,
-0.032798849046230316,
-0.02384820207953453,
-0.01391649805009365,
0.016847562044858932,
0.0269609447568655,
-0.003041584510356188,
0.006982472725212574,
0.04786597192287445,
0.027639206498861313,
-0.0005166454357095063,
-0.020093534141778946,
0.005992330145090818,
0.026597589254379272,
0.00975002720952034,
-0.015454701147973537,
-0.005619891453534365,
0.019403159618377686,
0.016811225563287735,
-0.031951021403074265,
0.026040444150567055,
0.013020222075283527,
-0.025386406108736992,
0.011784815229475498,
0.034373387694358826,
-0.01583016850054264,
0.05988090857863426,
-0.009895368479192257,
-0.028874613344669342,
-0.0382733978331089,
-0.026210010051727295,
-0.02819635160267353,
0.002352723851799965,
0.023569630458950996,
-0.011578913778066635,
0.0028220575768500566,
0.021038256585597992,
0.008841639384627342,
0.006443495862185955,
-0.036505069583654404,
0.014679543673992157,
0.008363221772015095,
0.016847562044858932,
0.025168392807245255,
-0.006425328087061644,
-0.011403292417526245,
-0.00913232285529375,
0.003282307181507349,
-0.0034670126624405384,
-0.036650411784648895,
-0.00753356097266078,
-0.007127814460545778,
0.01845843531191349,
0.02683982625603676,
0.00444504339247942,
-0.03287151828408241,
0.007036976050585508,
-0.021341051906347275,
-0.041349802166223526,
-0.017683278769254684,
-0.008999093435704708,
-0.007812133524566889,
-0.02069912478327751,
-0.014849109575152397,
0.02157117798924446,
0.0016305557219311595,
0.012172393500804901,
0.0008796220063231885,
0.0005794755998067558,
-0.033719345927238464,
-0.011942269280552864,
-0.012838544324040413,
-0.01488544512540102,
-0.030352257192134857,
0.019790736958384514,
-0.033719345927238464,
-0.002548027317970991,
-0.0261131152510643,
0.030231138691306114,
-0.005341318901628256,
-0.0008917337981984019,
-0.035778358578681946,
0.01687178574502468,
-0.009017260745167732,
-0.011869598180055618,
0.0028992705047130585,
0.0278329961001873,
-0.03531811013817787,
0.022891366854310036,
-0.04227030277252197,
-0.02004508674144745,
-0.00844194833189249,
0.019609060138463974,
0.01899135671555996,
-0.010385897941887379,
-0.01843421161174774,
0.002920466009527445,
-0.03512432053685188,
-0.03691687062382698,
-0.015091345645487309,
-0.004756922833621502,
-0.026088891550898552,
0.004551021847873926,
0.020771795883774757,
0.01586650311946869,
0.002864448819309473,
-0.008859806694090366,
0.0008152778609655797,
-0.023400064557790756,
0.01150018721818924,
0.015115569345653057,
-0.018882350996136665,
0.02855970524251461,
-0.013129228726029396,
-0.01808296889066696,
0.007884804159402847,
0.0038848710246384144,
-0.035269662737846375,
0.019366823136806488,
0.02836591750383377,
-0.04190694913268089,
0.010234500281512737,
0.04062309488654137,
0.020953474566340446,
-0.02613733895123005,
-0.012790096923708916,
-0.0165205430239439,
-0.014522089622914791,
-0.00222252169623971,
0.0016744611784815788,
0.0015578847378492355,
0.005541164427995682,
0.01184537447988987,
0.00826027151197195,
0.023896649479866028,
-0.03643240034580231,
0.009047540836036205,
0.01044645719230175,
0.014158735051751137,
0.00846011657267809,
-0.025289511308073997,
-0.03619016334414482,
0.019039804115891457,
0.009943815879523754,
0.01845843531191349,
0.0313938744366169,
-0.016944456845521927,
0.010755308903753757,
-0.009344280697405338,
0.0032913910690695047,
-0.025991996750235558,
0.009895368479192257,
-0.027251627296209335,
0.002540457295253873,
0.024429570883512497,
0.005159641616046429,
0.0004969637375324965,
0.028293246403336525,
0.008999093435704708,
-0.017889179289340973,
0.007666791323572397,
-0.02000875025987625,
-0.007969587109982967,
-0.02872927114367485,
-0.017889179289340973,
0.11763013899326324,
0.006249706726521254,
0.019391046836972237,
-0.0006101336912252009,
-0.020759684965014458,
-0.012087610550224781,
0.00889008678495884,
-0.0031854126136749983,
0.02054167166352272,
0.007212597411125898,
0.00281145959161222,
0.003491236362606287,
0.023642301559448242,
0.012475189752876759,
0.03451872989535332,
-0.018579553812742233,
-0.009592573158442974,
0.05900885909795761,
-0.009598628617823124,
0.003951486200094223,
0.021704407408833504,
0.005595667753368616,
0.002107459120452404,
0.03592370077967644,
-0.019899744540452957,
-0.010161829181015491,
0.0030082769226282835,
-0.01305655762553215,
0.00025775498943403363,
0.012287456542253494,
-0.0051990048959851265,
-0.0006616089376620948,
0.045540496706962585,
-0.037183333188295364,
0.02453857660293579,
-0.01105204876512289,
-0.01671433262526989,
-0.017537936568260193,
0.00539582222700119,
-0.0024390206672251225,
-0.008169432170689106,
0.0047266436740756035,
0.0015344180865213275,
0.01017999742180109,
0.028656600043177605,
0.022079873830080032,
-0.045031800866127014,
-0.005986274220049381,
0.013129228726029396,
-0.011227671056985855,
-0.0036819977685809135,
0.0027175929863005877,
-0.002499579917639494,
-0.006352657452225685,
-0.017114022746682167,
-0.04985231161117554,
0.030376480892300606,
0.008042258210480213,
-0.0037395290564745665,
-0.04319080337882042,
-0.02596777305006981,
0.02822057530283928,
0.014049728401005268,
-0.013553142547607422,
-0.00008189681830117479
] | 2024-12-30 | 12 | 39734708 | [
"CAR T cell therapy",
"CAR T therapy",
"anti-CEA CAR T therapy",
"novel cancer therapy",
"therapy",
"severe inflammation",
"colon cancer patients",
"severe adverse effects",
"Serious bowel inflammation",
"modified immune cells",
"serious side effects",
"severe colitis",
"CAR T",
"CAR T-cell therapy",
"refractory bloody diarrhea",
"intense diarrhea",
"inflammation",
"risks",
"carcinoembryonic antigen",
"patients",
"anti-CEA",
"cancer",
"hematological malignancies",
"advanced stages",
"metastatic colorectal adenocarcinoma",
"solid tumors",
"common medications",
"possible mechanisms",
"NCT05396300",
"complications"
] | [
"CAR-T-cell therapy",
"carcinoembryonic antigen",
"case report",
"colorectal cancer",
"immune-related adverse event"
] | 0 | 10.1177/17588359241309825 | [
"Ye",
"Yu",
"Shen"
] | [
"Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province, China.",
"Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province, China.",
"Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, Zhejiang Province 310003, China."
] | [
"39734708",
"29567707",
"28366766",
"22750462",
"32843493",
"31155611",
"28529185",
"21157437",
"20400962",
"37999667",
"27080226",
"33252123"
] | [] | 6.289252 | 4.126767 |
39734655 | 93 | Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers. | Thyroid cancer treatment has recently been revolutionized by the introduction of specific targeted therapies (e.g. BRAF | [
-0.03578217700123787,
0.03906306251883507,
0.047941964119672775,
0.0630340427160263,
-0.021920427680015564,
0.026575187221169472,
-0.0005385909462347627,
0.022679133340716362,
-0.0024478493724018335,
0.031045395880937576,
0.00970424897968769,
-0.04544028639793396,
0.011503610759973526,
0.006525889504700899,
-0.007786980830132961,
0.004393313080072403,
0.03727908059954643,
-0.01174967736005783,
0.0023568561300635338,
0.037135541439056396,
0.01564573124051094,
-0.04111361876130104,
0.0053980848751962185,
-0.054421715438365936,
0.015163850970566273,
0.04416894540190697,
-0.04478411003947258,
-0.018454991281032562,
-0.03371111676096916,
-0.04125715792179108,
0.03840688616037369,
-0.021448800340294838,
0.03547459468245506,
-0.016014831140637398,
-0.029712535440921783,
-0.011390830390155315,
0.03254229947924614,
-0.003919122274965048,
0.006771956104785204,
0.03904255852103233,
0.019367488101124763,
0.009294138289988041,
0.018260188400745392,
0.03869396448135376,
-0.05581609159708023,
0.009550457820296288,
-0.017224658280611038,
-0.026862263679504395,
-0.016578733921051025,
-0.019664818421006203,
-0.010222014039754868,
0.008709730580449104,
-0.05643125995993614,
0.045194219797849655,
-0.06377224624156952,
0.011790688149631023,
-0.018895858898758888,
0.0305122509598732,
-0.009007060900330544,
0.003744825255125761,
0.004401002544909716,
-0.013543912209570408,
0.02963051199913025,
0.012877481989562511,
-0.058481812477111816,
0.016845304518938065,
-0.020403016358613968,
0.003347530262544751,
0.002044146414846182,
-0.02788754180073738,
0.020044170320034027,
0.0010432195849716663,
-0.015861038118600845,
0.0372585766017437,
0.054093629121780396,
-0.022802166640758514,
-0.008356009609997272,
0.04055996984243393,
0.011349819600582123,
0.06151663511991501,
0.02419654279947281,
-0.04855712875723839,
0.02520131506025791,
-0.008566191419959068,
-0.035043977200984955,
-0.013154307380318642,
-0.006090146955102682,
0.038878511637449265,
-0.042897600680589676,
-0.01787058264017105,
-0.01495879516005516,
0.033116456121206284,
-0.005013605579733849,
0.012487877160310745,
-0.02475019358098507,
0.053601495921611786,
-0.01215978804975748,
0.0017480977112427354,
0.03434678912162781,
0.011319060809910297,
0.03309594839811325,
0.014446156099438667,
-0.008981429040431976,
-0.006828346289694309,
0.08292442560195923,
-0.007792107295244932,
0.0017404081299901009,
-0.0008163769962266088,
0.037955764681100845,
0.038611941039562225,
0.06159865856170654,
-0.04035491123795509,
0.003744825255125761,
-0.006454120390117168,
-0.04544028639793396,
-0.08554913103580475,
-0.009453056380152702,
-0.01495879516005516,
0.02019796147942543,
-0.005180213134735823,
-0.026493163779377937,
0.013482395559549332,
0.0036525502800941467,
-0.0161686223000288,
0.015307389199733734,
0.026882769539952278,
0.060778435319662094,
-0.021100206300616264,
-0.02700580283999443,
-0.01640443690121174,
0.02059781923890114,
-0.018413979560136795,
0.006402856204658747,
0.04144170507788658,
-0.03188612312078476,
-0.04297962412238121,
-0.02487322688102722,
0.04023187980055809,
-0.024832215160131454,
0.039104074239730835,
-0.019531531259417534,
0.02228952758014202,
-0.0007228204631246626,
-0.004936710000038147,
-0.0046803904697299,
-0.07812612503767014,
-0.05634923651814461,
0.02140778861939907,
0.030860844999551773,
0.030758317559957504,
-0.05294531583786011,
0.014866519719362259,
0.031188933178782463,
0.052166108042001724,
-0.015420169569551945,
0.027456924319267273,
0.009668364189565182,
0.03145550563931465,
-0.020761864259839058,
-0.051345884799957275,
-0.031024890020489693,
0.012856977060437202,
-0.0039011798799037933,
-0.008161206729710102,
0.04806499928236008,
-0.017655273899435997,
-0.002382487989962101,
0.07242558151483536,
-0.07263064384460449,
0.02249458245933056,
0.015994325280189514,
-0.03315746784210205,
-0.038878511637449265,
-0.006146537140011787,
-0.03330100327730179,
0.02088489755988121,
0.07176940888166428,
-0.0034885057248175144,
0.012969757430255413,
-0.030061129480600357,
-0.018096143379807472,
0.04626050963997841,
0.0029604879673570395,
0.0296920295804739,
0.02491423673927784,
0.010447574779391289,
-0.015830280259251595,
-0.02727237530052662,
-0.028851302340626717,
0.004383060149848461,
-0.0013431132538244128,
0.03176308795809746,
0.0063413395546376705,
0.06131158024072647,
-0.007802359759807587,
0.011401083320379257,
0.021694866940379143,
0.04004732891917229,
-0.019193189218640327,
-0.004603494890034199,
0.012713437899947166,
-0.05187902972102165,
-0.03947317227721214,
0.008976302109658718,
-0.025488391518592834,
-0.05971214547753334,
-0.007597304414957762,
0.04507118836045265,
-0.00766907399520278,
0.00043702442781068385,
-0.0013559291837736964,
-0.06627392023801804,
0.032193705439567566,
0.0245246309787035,
-0.012180293910205364,
-0.02045428194105625,
0.008812258020043373,
-0.03524903208017349,
0.06397730112075806,
0.001212390372529626,
0.03729958459734917,
0.003642297349870205,
0.041851818561553955,
0.050730716437101364,
-0.03362909331917763,
0.021817900240421295,
0.017193898558616638,
-0.002513210754841566,
-0.02085413970053196,
0.011462599970400333,
-0.00947868824005127,
0.02026973105967045,
0.030471239238977432,
-0.0008464945130981505,
-0.018639540299773216,
0.00013472784485202283,
0.0543396957218647,
-0.00909933540970087,
0.06492055207490921,
-0.08034072816371918,
-0.005249419715255499,
0.006936000660061836,
-0.021551327779889107,
-0.011698413640260696,
-0.05667732656002045,
0.0008605921175330877,
0.018916364759206772,
-0.028564224019646645,
-0.007720337714999914,
0.03637683764100075,
-0.03143500164151192,
0.03496195375919342,
-0.01591230370104313,
-0.0020774679724127054,
0.04125715792179108,
0.01026302482932806,
0.02183840610086918,
0.0029758671298623085,
-0.030819833278656006,
0.029999611899256706,
0.002251765225082636,
0.02317126654088497,
0.007581925485283136,
-0.04088805615901947,
-0.08841990679502487,
0.019992906600236893,
-0.01761426404118538,
0.05388857051730156,
0.04252849891781807,
-0.008422652259469032,
0.020403016358613968,
-0.016681261360645294,
0.04441501200199127,
-0.07279468327760696,
0.0024427231401205063,
-0.024401597678661346,
0.014384639449417591,
0.030327701941132545,
-0.02161284349858761,
0.0228841882199049,
0.02743641845881939,
-0.002968177665024996,
0.01386174838989973,
-0.05581609159708023,
-0.02189992181956768,
0.0011873992625623941,
-0.02196143940091133,
-0.006243938580155373,
0.020310742780566216,
-0.018014121800661087,
0.014415398240089417,
0.002036456950008869,
-0.025447381660342216,
-0.040313903242349625,
-0.019962148740887642,
0.01712213084101677,
0.0033090822398662567,
-0.028113102540373802,
0.03338302671909332,
-0.002241512294858694,
-0.039924297481775284,
-0.00939666572958231,
-0.0245246309787035,
-0.03898104280233383,
0.05114082992076874,
0.04367681220173836,
-0.02700580283999443,
-0.03980126231908798,
0.01904965192079544,
0.05520092695951462,
-0.014189837500452995,
-0.016712019219994545,
-0.006741197779774666,
-0.022022955119609833,
0.01567648909986019,
0.007407627999782562,
0.03289089351892471,
0.0031117163598537445,
-0.005505738779902458,
-0.012815965339541435,
-0.006295202299952507,
-0.024893730878829956,
-0.01317481230944395,
0.026103558018803596,
0.005336568225175142,
-0.034490328282117844,
0.002183840610086918,
-0.00721795205026865,
0.04986948519945145,
0.010406563989818096,
0.017624516040086746,
-0.0042702797800302505,
0.0476548857986927,
-0.05097678303718567,
-0.013308098539710045,
0.029056357219815254,
0.0010092572774738073,
-0.06799639016389847,
0.027620969340205193,
0.021530821919441223,
-0.0002898010134231299,
-0.023683903738856316,
-0.020833633840084076,
0.007904887199401855,
0.02059781923890114,
-0.0015930244699120522,
-0.008473916910588741,
-0.027128836140036583,
-0.0042343949899077415,
0.03924761340022087,
0.015461181290447712,
0.04937735199928284,
0.0576205812394619,
0.009468435309827328,
-0.05323239415884018,
0.006771956104785204,
0.001823711907491088,
0.011257544159889221,
0.012385348789393902,
0.012518635019659996,
-0.024381093680858612,
-0.019387992098927498,
-0.014025792479515076,
0.05204307287931442,
0.027128836140036583,
0.033731620758771896,
0.0031373484525829554,
0.017111876979470253,
-0.00400883425027132,
-0.009468435309827328,
-0.004283095709979534,
-0.006982137914747,
-0.0002468675374984741,
-0.018588276579976082,
-0.020618325099349022,
-0.007007769774645567,
0.016096852719783783,
-0.0038063416723161936,
0.01705036126077175,
0.029671523720026016,
-0.00392937520518899,
-0.016742777079343796,
-0.000533144164364785,
0.012672427110373974,
-0.019470015540719032,
-0.0041754418052732944,
0.013297845609486103,
-0.013379868119955063,
-0.03250128775835037,
0.004903388675302267,
0.014425651170313358,
0.00573642598465085,
0.015071575529873371,
0.012303327210247517,
-0.030368711799383163,
0.06844750791788101,
0.0020928471349179745,
0.08386767655611038,
0.05860484763979912,
0.029486972838640213,
-0.0009855477837845683,
0.0203004889190197,
0.033936675637960434,
-0.03935014083981514,
0.011134510859847069,
-0.04654758796095848,
-0.031906627118587494,
-0.012057260610163212,
0.003898616647347808,
-0.01591230370104313,
-0.02930242381989956,
0.02382744289934635,
0.03194763883948326,
0.024934742599725723,
0.00988879892975092,
-0.038119807839393616,
-0.0072333309799432755,
0.0044471402652561665,
-0.023642893880605698,
0.008740488439798355,
0.011185774579644203,
-0.029015345498919487,
-0.008622582070529461,
-0.009422297589480877,
-0.0034808162599802017,
0.01322607696056366,
0.01630190759897232,
-0.005772310774773359,
-0.01204700767993927,
-0.0168965682387352,
0.007515282370150089,
0.033054936677217484,
-0.04062148556113243,
-0.030963372439146042,
0.029671523720026016,
0.0475318543612957,
-0.04490714520215988,
0.01064237765967846,
-0.022843176499009132,
0.010073348879814148,
-0.06750425696372986,
-0.015830280259251595,
0.017655273899435997,
-0.05032060667872429,
-0.018024373799562454,
-0.014856267720460892,
-0.024668170139193535,
0.005772310774773359,
-0.038119807839393616,
-0.023745421320199966,
0.027046814560890198,
-0.02870776318013668,
-0.028113102540373802,
0.0037730203475803137,
-0.005346820689737797,
-0.04699870944023132,
-0.013913012109696865,
-0.0390835702419281,
-0.020218467339873314,
0.00494439946487546,
0.06742223352193832,
-0.030655790120363235,
-0.0288718082010746,
-0.08612328767776489,
-0.01506132259964943,
0.04544028639793396,
0.05064869672060013,
0.026882769539952278,
-0.003203991334885359,
-0.05954810231924057,
0.005149454809725285,
0.0357411652803421,
-0.050853751599788666,
-0.03729958459734917,
0.01751173473894596,
0.03112741746008396,
-0.010288657620549202,
-0.006812967360019684,
0.011780435219407082,
0.03633582592010498,
-0.006869357544928789,
0.0021223239600658417,
-0.021879415959119797,
-0.004398439545184374,
-0.013718209229409695,
0.016281403601169586,
0.008520053699612617,
0.05306835100054741,
0.003255255287513137,
0.004147246479988098,
0.017829570919275284,
-0.000276824866887182,
0.04322568699717522,
-0.005572381895035505,
0.00046553995343856514,
0.003098900429904461,
0.015235619619488716,
-0.004113925155252218,
0.020382512360811234,
-0.030389217659831047,
0.022638121619820595,
0.027210857719182968,
0.050361618399620056,
0.0021851221099495888,
-0.008796879090368748,
0.03157854080200195,
0.017357943579554558,
0.06479752063751221,
-0.0014251354150474072,
0.027477430179715157,
-0.037340596318244934,
-0.020977173000574112,
0.01577901653945446,
-0.011401083320379257,
-0.03106589987874031,
0.02327379398047924,
-0.0020095433574169874,
0.00311427959240973,
0.006418235599994659,
-0.02618558146059513,
-0.0320911779999733,
-0.005813322030007839,
-0.031045395880937576,
-0.017880834639072418,
0.016414688900113106,
-0.025324348360300064,
-0.011862457729876041,
-0.030963372439146042,
-0.0220639668405056,
-0.018516506999731064,
0.010929455049335957,
-0.00950944609940052,
0.005900470539927483,
-0.012221304699778557,
-0.03502346947789192,
0.009678617119789124,
-0.014743486419320107,
0.0015917429700493813,
-0.039596207439899445,
0.003949880599975586,
0.010216888040304184,
-0.00965811125934124,
-0.007561419624835253,
-0.009048071689903736,
-0.027087824419140816,
0.007207699120044708,
0.008684098720550537,
-0.059466078877449036,
0.013205571100115776,
0.002028767252340913,
0.04597343131899834,
-0.02376592718064785,
0.025816481560468674,
0.023909466341137886,
0.011821446940302849,
0.0036679294425994158,
0.009319770149886608,
0.0009759357781149447,
0.027846530079841614,
0.012672427110373974,
-0.034223753958940506,
-0.012836471199989319,
0.030163656920194626,
-0.04351276531815529,
0.030163656920194626,
0.03157854080200195,
-0.012303327210247517,
-0.021100206300616264,
-0.038837503641843796,
0.007956151850521564,
-0.013246581889688969,
-0.0320911779999733,
0.021592339500784874,
-0.01836271584033966,
0.020936161279678345,
0.014671717770397663,
-0.012180293910205364,
0.02942545711994171,
0.008263734169304371,
0.0031014636624604464,
-0.002883592154830694,
0.021100206300616264,
-0.02098742499947548,
0.03137348219752312,
-0.05027959495782852,
-0.014251354150474072,
-0.03207067400217056,
0.0027554326225072145,
-0.004908514674752951,
-0.013738715089857578,
0.04498916491866112,
-0.01415907870978117,
0.04445601999759674,
-0.002732363762333989,
0.007910014130175114,
-0.027087824419140816,
-0.04033440724015236,
0.014938289299607277,
-0.03512599691748619,
0.009114714339375496,
0.012498130090534687,
0.005454475060105324,
0.019531531259417534,
-0.03678694739937782,
-0.022248515859246254,
0.0052545457147061825,
-0.022084472700953484,
-0.0424874909222126,
0.022187000140547752,
-0.005116133484989405,
-0.02216649428009987,
0.010350174270570278,
-0.002968177665024996,
-0.007346111349761486,
0.002136421389877796,
0.007381996139883995,
0.014917784370481968,
0.004185694269835949,
0.032029662281274796,
-0.012498130090534687,
-0.005915849935263395,
0.016189128160476685,
-0.008217597380280495,
-0.00207874970510602,
-0.036684419959783554,
0.0029143504798412323,
-0.008294492959976196,
-0.03729958459734917,
0.01603533700108528,
-0.016055840998888016,
-0.02848220244050026,
0.019223948940634727,
0.011647149920463562,
0.054421715438365936,
0.002283805049955845,
-0.029261412099003792,
0.018506255000829697,
-0.013625934720039368,
0.006074767559766769,
0.03139398992061615,
-0.035864196717739105,
0.0021748694125562906,
-0.004316417034715414,
0.019859619438648224,
0.01556370873004198,
0.01245711836963892,
0.008109943009912968,
-0.032521795481443405,
-0.008586697280406952,
-0.03496195375919342,
0.0007702395087108016,
-0.006418235599994659,
0.015092081390321255,
0.021551327779889107,
0.00728459469974041,
-0.004624000284820795,
-0.03430577740073204,
0.009007060900330544,
0.03848890960216522,
0.03387515991926193,
-0.021920427680015564,
0.008612329140305519,
-0.009165978990495205,
-0.018947124481201172,
-0.010724400170147419,
0.026247097179293633,
0.004987973719835281,
0.002372235292568803,
0.02788754180073738,
0.027620969340205193,
0.07201547175645828,
-0.035536110401153564,
0.06734021008014679,
0.008007415570318699,
0.025939514860510826,
0.010652630589902401,
0.008397020399570465,
-0.007351237814873457,
-0.051345884799957275,
0.012293074280023575,
0.0043036011047661304,
-0.013964275829494,
-0.03151702135801315,
-0.009986200369894505,
0.0003985765215475112,
-0.0032244969625025988,
0.0019134236499667168,
0.0322757288813591,
0.00438562361523509,
0.0029271666426211596,
-0.006884736940264702,
0.0025772906374186277,
-0.0035859071649610996,
-0.005123822949826717,
-0.012856977060437202,
-0.028338663280010223,
0.026144569739699364,
0.05003352835774422,
-0.021448800340294838,
-0.03348555415868759,
0.053150374442338943,
0.017655273899435997,
-0.022248515859246254,
-0.01977759785950184,
0.01201624982059002,
-0.004859813954681158,
0.0058697122149169445,
-0.013851495459675789,
0.05052566155791283,
-0.011349819600582123,
-0.026165075600147247,
0.0028092595748603344,
-0.0009778582025319338,
0.013718209229409695,
-0.030327701941132545,
0.0030348205473273993,
-0.03256280720233917,
0.05302733927965164,
0.01685555838048458,
0.004160062409937382,
0.01976734586060047,
0.005016169045120478,
0.011923974379897118,
0.001073337160050869,
0.015963567420840263,
0.024237554520368576,
-0.022761154919862747,
0.024729687720537186,
0.012354590930044651,
-0.0021171974949538708,
-0.012938998639583588,
-0.004752160049974918,
-0.014579442329704762,
-0.019890379160642624,
-0.020577315241098404,
-0.014210342429578304,
-0.030204668641090393,
-0.04318467900156975,
0.03656138852238655,
-0.014640958979725838,
0.00803817342966795,
-0.04851612076163292,
-0.020833633840084076,
-0.007807486224919558,
-0.02255610004067421,
0.01265192124992609,
0.015573961660265923,
0.0524531826376915,
0.0012559646274894476,
-0.029938096180558205,
0.01029890961945057,
0.003306519240140915,
-0.0024581023026257753,
-0.02140778861939907,
-0.0030655788723379374,
-0.043553777039051056,
0.0011329313274472952,
-0.008243229240179062,
-0.02189992181956768,
-0.057169459760189056,
-0.042610522359609604,
-0.028933323919773102,
0.025365358218550682,
-0.032624322921037674,
0.00831499882042408,
0.027190351858735085,
0.013287593610584736,
-0.00524685624986887,
-0.024668170139193535,
-0.0018147407099604607,
-0.02864624559879303,
-0.023581376299262047,
0.0007785698981024325,
0.0016237827949225903,
0.01201624982059002,
0.049910496920347214,
-0.024237554520368576,
0.03358808159828186,
0.0030527629423886538,
-0.0009605566156096756,
0.035536110401153564,
0.0008150954381562769,
-0.011072994209825993,
0.02569344826042652,
-0.0012450710637494922,
-0.015379158779978752,
0.008289366960525513,
-0.013789978809654713,
0.002209472469985485,
-0.017429713159799576,
0.00816633366048336,
0.026083054021000862,
-0.027313385158777237,
0.003990891855210066,
-0.0037115036975592375,
0.012805712409317493,
0.02837967500090599,
-0.039821770042181015,
-0.022310033440589905,
0.009765765629708767,
-0.04802398756146431,
-0.02848220244050026,
0.02694428525865078,
-0.003296266309916973,
-0.03865295276045799,
-0.0053622000850737095,
-0.03225522115826607,
0.036848463118076324,
-0.009714501909911633,
0.04045743867754936,
-0.003024567849934101,
-0.004011397249996662,
-0.013236328959465027,
-0.0035090113524347544,
-0.05192004144191742,
-0.005961987189948559,
0.0069616325199604034,
0.004916204605251551,
0.04507118836045265,
0.00479573430493474,
0.06910368800163269,
0.007602430880069733,
0.020567061379551888,
-0.01764502190053463,
-0.010785916820168495,
-0.019992906600236893,
-0.0030707053374499083,
-0.0015802085399627686,
0.039596207439899445,
-0.031640056520700455,
0.03217320144176483,
-0.005838953889906406,
-0.012477624230086803,
0.01706061325967312,
0.03611026331782341,
-0.0072333309799432755,
0.01322607696056366,
0.015522697940468788,
0.022576605901122093,
0.022269021719694138,
0.010703894309699535,
-0.023355815559625626,
-0.015440675429999828,
-0.013297845609486103,
-0.038837503641843796,
0.025262830778956413,
-0.019818609580397606,
0.026985296979546547,
-0.025426875799894333,
-0.03315746784210205,
-0.019603300839662552,
-0.012313580140471458,
-0.04379984363913536,
0.0013930954737588763,
0.012682679109275341,
-0.007992035709321499,
0.002591388300061226,
0.026739230379462242,
0.016055840998888016,
-0.04004732891917229,
-0.016906822100281715,
-0.01286722905933857,
-0.0063413395546376705,
-0.029999611899256706,
0.019562289118766785,
-0.02278166078031063,
0.0012982572661712766,
0.03207067400217056,
-0.000045456628868123516,
-0.07566545903682709,
0.026042042300105095,
0.062049780040979385,
-0.029733039438724518,
-0.01673252508044243,
0.03670492395758629,
0.025919009000062943,
-0.026329120621085167,
-0.01122678630053997,
-0.02909736894071102,
0.003547459375113249,
0.02864624559879303,
-0.014343628659844398,
0.011401083320379257,
0.007351237814873457,
0.013297845609486103,
0.02245357260107994,
-0.0509357750415802,
0.023396827280521393,
-0.016876064240932465,
0.01124729122966528,
0.019798103719949722,
0.013164560310542583,
-0.00239786715246737,
0.0015891797374933958,
0.021940933540463448,
-0.0029912462923675776,
-0.007294847629964352,
-0.0006798869580961764,
-0.0015135655412450433,
-0.03727908059954643,
-0.009576089680194855,
-0.012938998639583588,
-0.02612406387925148,
-0.007443512789905071,
-0.003083521267399192,
0.022145988419651985,
-0.022145988419651985,
0.005823574960231781,
-0.028338663280010223,
0.03791475296020508,
-0.044702086597681046,
-0.004052408505231142,
-0.023396827280521393,
0.0053622000850737095,
-0.028113102540373802,
0.004208763130009174,
-0.026964791119098663,
0.07250760495662689,
-0.006977011449635029,
0.0008580288849771023,
0.0030527629423886538,
0.01383099053055048,
-0.013328604400157928,
-0.015573961660265923,
-0.005336568225175142,
0.011718918569386005,
-0.006766829639673233,
0.017327185720205307,
-0.018506255000829697,
0.03381364420056343,
0.021325767040252686,
0.018731815740466118,
0.018772825598716736,
0.025754963979125023,
0.0371970571577549,
0.013482395559549332,
0.02228952758014202,
0.002993809524923563,
-0.01656848005950451,
-0.0021505190525203943,
0.027969563379883766,
-0.010375806130468845,
0.005521118175238371,
-0.035597626119852066,
-0.016342919319868088,
-0.004416381940245628,
0.006464372854679823,
0.043266698718070984,
-0.010693641379475594,
0.020515797659754753,
0.03490043804049492,
-0.017501482740044594,
0.03274735435843468,
0.023909466341137886,
-0.005803069099783897,
-0.027477430179715157,
-0.01882409118115902,
-0.019664818421006203,
0.020413270220160484,
-0.013779725879430771,
-0.023150760680437088,
-0.02298671565949917,
0.0186600461602211,
0.04544028639793396,
-0.013492648489773273,
0.02349935472011566,
0.024381093680858612,
0.03276786208152771,
-0.06241887807846069,
0.029117874801158905,
0.008273987099528313,
-0.014405145309865475,
-0.002878465922549367,
0.01908040978014469,
-0.020433776080608368,
0.02042352221906185,
0.013923265039920807,
0.016527468338608742,
0.00683347275480628,
0.02304823324084282,
0.01764502190053463,
0.0339776873588562,
-0.026267603039741516,
-0.026247097179293633,
-0.005111007019877434,
-0.013010768219828606,
-0.024401597678661346,
0.0075357877649366856,
-0.014056551270186901,
0.0074691446498036385,
0.03947317227721214,
0.01245711836963892,
-0.032952409237623215,
0.03207067400217056,
0.012477624230086803,
-0.015010058879852295,
-0.006695060525089502,
-0.03565914183855057,
0.015932807698845863,
0.043389733880758286,
0.027190351858735085,
-0.008709730580449104,
0.027969563379883766,
0.015399664640426636,
-0.04847510904073715,
-0.005787690170109272,
0.05544699355959892,
-0.022597109898924828,
0.0186600461602211,
0.006669428665190935,
-0.014979301020503044,
0.012672427110373974,
-0.010806421749293804,
-0.0072999740950763226,
-0.012385348789393902,
-0.0561031699180603,
0.0195725429803133,
0.01624039188027382,
-0.03967823088169098,
0.006951379589736462,
0.006407982669770718,
-0.020833633840084076,
0.004347175359725952,
0.07562445104122162,
0.02173587679862976,
-0.018608782440423965,
-0.004242084454745054,
-0.031250450760126114,
0.01967507041990757,
0.023150760680437088,
0.029404951259493828,
-0.024996260181069374,
0.0056697833351790905,
0.0005276973824948072,
0.0007516563637182117,
-0.0036294814199209213,
0.019357234239578247,
0.056390248239040375,
0.01001695916056633,
-0.008320124819874763,
-0.028297651559114456,
-0.017604010179638863,
0.033075444400310516,
0.017327185720205307,
-0.027231363579630852,
-0.04544028639793396,
-0.032419268041849136,
-0.0021441110875457525,
0.01666075550019741,
-0.02343783713877201,
0.029507478699088097,
0.0055262441746890545,
0.005715920589864254,
0.008376515470445156,
-0.0178090650588274,
0.021387282758951187,
-0.012190546840429306,
-0.028523212298750877,
-0.016773534938693047,
-0.021366778761148453,
-0.009012186899781227,
-0.007515282370150089,
0.01770653761923313,
-0.006869357544928789,
-0.021100206300616264,
0.02842068485915661,
0.03951418399810791,
0.0015122839249670506,
0.01603533700108528,
-0.02431957609951496,
-0.010591113939881325,
0.020054422318935394,
-0.0186600461602211,
0.012303327210247517,
-0.03615127503871918,
0.004967468325048685,
0.015348399989306927,
-0.0014956231461837888,
0.006782209035009146,
-0.003775583580136299,
0.03459285572171211,
0.005844080355018377,
0.0038319737650454044,
-0.01580977439880371,
-0.014323122799396515,
-0.024114521220326424,
-0.002241512294858694,
-0.03764818236231804,
-0.003286013612523675,
0.010888444259762764,
-0.018229428678750992,
0.027231363579630852,
-0.04769589751958847,
-0.03371111676096916,
-0.014938289299607277,
0.01163689699023962,
-0.0022556099575012922,
-0.004662448074668646,
0.011821446940302849,
0.02399148792028427,
0.04498916491866112,
-0.020310742780566216,
0.02507828176021576,
-0.013625934720039368,
-0.04888521879911423,
0.06664302200078964,
0.023888960480690002,
-0.023335309699177742,
-0.0074332598596811295,
-0.013010768219828606,
0.002600359497591853,
-0.01976734586060047,
-0.01374896802008152,
0.04490714520215988,
0.046793654561042786,
0.03809930384159088,
-0.029240906238555908,
0.02766198106110096,
0.018680552020668983,
-0.03801728039979935,
0.015348399989306927,
-0.04170827940106392,
0.023355815559625626,
0.02310974895954132,
0.0029348561074584723,
-0.01294925156980753,
0.0018365278374403715,
0.04043693467974663,
-0.007566546089947224,
-0.025160303339362144,
-0.02072085253894329,
0.05733350291848183,
-0.01649671047925949,
-0.00008907096344046295,
-0.0003697406209539622,
0.04560433328151703,
-0.006977011449635029,
-0.008176585659384727,
0.0023632640950381756,
-0.018147407099604607,
0.003468000330030918,
0.040088340640068054,
-0.01673252508044243,
-0.004957215394824743,
0.0004860454937443137,
0.02167436107993126,
0.009119841270148754,
0.03100438416004181,
0.0014494856586679816,
-0.017788561061024666,
0.04033440724015236,
0.019131673499941826,
0.005741552449762821,
-0.006664302200078964,
0.006587406154721975,
0.001441796077415347,
0.02612406387925148,
0.017275922000408173,
0.007258962839841843,
0.007997162640094757,
-0.01427185907959938,
0.0008843016112223268,
0.03346505016088486,
-0.006197800859808922,
-0.015830280259251595,
0.010355300270020962,
-0.0003035781846847385,
0.005149454809725285,
0.0664379671216011,
-0.037955764681100845,
0.02491423673927784,
-0.016250643879175186,
-0.01012973953038454,
0.0424874909222126,
0.019849367439746857,
-0.0037858362775295973,
0.005223787389695644,
0.0008266298100352287,
-0.006597659084945917,
-0.030778823420405388,
-0.034059710800647736,
-0.01064237765967846,
0.007182067260146141,
-0.017532240599393845,
-0.01758350431919098,
0.017686031758785248,
0.006059388630092144,
-0.014487167820334435,
0.01764502190053463,
0.010939707979559898,
-0.005546750035136938,
-0.006894989404827356,
0.008981429040431976,
-0.010724400170147419,
0.019880125299096107,
-0.013759220950305462,
0.00044535481720231473,
-0.05856383591890335,
-0.00043478162842802703,
0.01912142150104046,
-0.010375806130468845,
-0.00009387695172335953,
0.00020601664436981082,
0.006541268900036812,
-0.047121740877628326,
0.0009567118249833584,
0.015030564740300179,
-0.023294299840927124,
0.009278759360313416,
-0.009878545999526978,
-0.019203443080186844,
-0.023027727380394936,
-0.027128836140036583,
-0.011001224629580975,
0.002675973577424884,
-0.029179390519857407,
-0.021858910098671913,
0.002617020159959793,
-0.0195725429803133,
0.026800747960805893,
-0.0012258471688255668,
0.002711858367547393,
0.023950476199388504,
0.029507478699088097,
0.018547264859080315,
-0.012026501819491386,
0.03670492395758629,
0.01954178512096405,
0.0018980444874614477,
0.020515797659754753,
0.011308807879686356,
-0.021858910098671913,
0.04560433328151703,
-0.016517216339707375,
-0.002297902712598443,
-0.01226231548935175,
0.020474785938858986,
0.01265192124992609,
0.041687771677970886,
0.018834343180060387,
-0.011216533370316029,
-0.008422652259469032,
-0.03430577740073204,
-0.023745421320199966,
0.02639063633978367,
-0.006428488530218601,
-0.012508382089436054,
0.0034346787724643946,
-0.0003038985887542367,
-0.024709181860089302,
0.01265192124992609,
-0.01624039188027382,
0.003265507984906435,
-0.02942545711994171,
-0.03223471716046333,
0.018547264859080315,
-0.012200798839330673,
-0.023745421320199966,
-0.02366339974105358,
0.018567770719528198,
-0.011862457729876041,
-0.00766907399520278,
0.015215114690363407,
-0.013820737600326538,
-0.05515991523861885,
-0.026083054021000862,
-0.0037166299298405647,
0.014712728559970856,
-0.0045752995647490025,
0.007248710375279188,
-0.05237116292119026,
0.013205571100115776,
-0.04556332156062126,
0.04396388679742813,
0.03217320144176483,
0.0074332598596811295,
-0.0036166654899716377,
0.019716082140803337,
-0.009299264289438725,
0.01533814799040556,
-0.007920267060399055,
0.01613786444067955,
0.00812019594013691,
0.01435388159006834,
0.02337632142007351,
0.03770969808101654,
-0.0038063416723161936,
0.010724400170147419,
0.0008311153505928814,
0.01243661344051361,
0.010826927609741688,
-0.0006456042756326497,
-0.03157854080200195,
-0.0016814547125250101,
-0.01640443690121174,
-0.0075050294399261475,
-0.005464727524667978,
0.027026308700442314,
0.013543912209570408,
-0.019603300839662552,
-0.009724754840135574,
0.008125321939587593,
0.02585749141871929,
-0.017214404419064522,
-0.05438070371747017,
0.006264443974941969,
0.0027451799251139164,
-0.029733039438724518,
-0.0038576056249439716,
0.018485749140381813,
0.014671717770397663,
0.03598723188042641,
0.013410625979304314,
0.01924445480108261,
0.04671163111925125,
0.032357748597860336,
-0.00985291413962841,
0.030143151059746742,
0.023150760680437088,
-0.03984227403998375,
-0.013103043660521507,
0.007607557345181704,
-0.029835568740963936,
-0.00788950826972723,
0.02782602421939373,
-0.002392740687355399,
0.015584214590489864,
0.04049845039844513,
-0.01404629833996296,
0.03473639488220215,
-0.0034141731448471546,
-0.052166108042001724,
0.028769278898835182,
-0.013779725879430771,
-0.004211326129734516,
0.004490714520215988,
0.004798297304660082,
-0.006982137914747,
0.0015545766800642014,
0.019439255818724632,
0.030225172638893127,
0.001044501201249659,
0.01256989873945713,
0.040477946400642395,
0.0031219692900776863,
-0.00970424897968769,
0.008007415570318699,
0.023642893880605698,
0.029610006138682365,
0.02589850313961506,
0.016742777079343796,
-0.014887025579810143,
-0.008894280530512333,
-0.0014674280537292361,
0.04490714520215988,
0.010068222880363464,
0.01083718053996563,
0.0055621289648115635,
-0.025508897379040718,
0.00027586365467868745,
0.005280178040266037,
0.029999611899256706,
0.03930912911891937,
0.005982492584735155,
0.0029758671298623085,
-0.012487877160310745,
0.027805518358945847,
-0.012692932039499283,
-0.017604010179638863,
-0.012467371299862862,
0.006515637040138245,
-0.02042352221906185,
0.01322607696056366,
-0.015184355899691582,
0.01574825868010521,
-0.03321898356080055,
0.0011630489025264978,
-0.0017750111874192953,
0.014917784370481968,
0.004631689749658108,
-0.0066489228047430515,
-0.0052545457147061825,
0.00045656878501176834,
-0.009617100469768047,
-0.01265192124992609,
0.008289366960525513,
0.0024068383499979973,
-0.02942545711994171,
-0.03463386371731758,
-0.039862778037786484,
-0.0020018538925796747,
0.002324816072359681,
0.01898813433945179,
0.005659530404955149,
-0.017573252320289612,
-0.007346111349761486,
-0.011493357829749584,
0.020833633840084076,
0.007812612690031528,
0.02216649428009987,
-0.011790688149631023,
0.005187903065234423,
0.002576009137555957,
0.025447381660342216,
0.012405854649841785,
0.005690288729965687,
-0.006044009234756231,
-0.027805518358945847,
-0.0035961598623543978,
0.021633349359035492,
0.0006241375231184065,
-0.020761864259839058,
0.0341007225215435,
-0.03446982055902481,
-0.0040037077851593494,
-0.0005555720999836922,
-0.007402501534670591,
0.009975947439670563,
0.03303443267941475,
0.020013412460684776,
-0.006284949369728565,
-0.006618164479732513,
0.001813459093682468,
-0.04347175359725952,
-0.019685322418808937,
0.004483024589717388,
0.014118067920207977,
-0.035146504640579224,
0.010160497389733791,
0.02540636993944645,
-0.03008163534104824,
0.000552688492462039,
0.004024213179945946,
-0.02491423673927784,
0.00234404020011425,
-0.044045910239219666,
0.014230848290026188,
0.007766474969685078,
0.02458614856004715,
-0.00033609868842177093,
0.027785014361143112,
-0.05138689652085304,
0.008130448870360851,
-0.0009823438012972474,
-0.021387282758951187,
-0.02524232678115368,
-0.01591230370104313,
0.004393313080072403,
-0.012897987850010395,
0.014979301020503044,
0.022904694080352783,
0.011780435219407082,
0.02327379398047924,
-0.013431131839752197,
0.02343783713877201,
-0.00573642598465085,
-0.042118389159440994,
0.03539257124066353,
-0.027928551658988,
-0.009335149079561234,
0.014456409029662609,
0.01816791296005249,
-0.002804133342579007,
0.01053985022008419,
0.01983911544084549,
-0.030307196080684662,
-0.027231363579630852,
0.020966919139027596,
0.04109311103820801,
-0.009268506430089474,
0.010452701710164547,
0.06693010032176971,
-0.026431648060679436,
-0.024504126980900764,
0.021325767040252686,
-0.01083718053996563,
-0.007848497480154037,
0.010360426269471645,
-0.002668284112587571,
0.045030176639556885,
-0.021120712161064148,
0.005972240120172501,
0.023335309699177742,
0.000519687426276505,
0.041851818561553955,
0.02200244925916195,
-0.029240906238555908,
-0.012672427110373974,
0.003975512459874153,
-0.008858395740389824,
-0.0067258188501000404,
0.00001055314623954473,
0.022084472700953484,
-0.0001839091128204018,
0.017439965158700943,
-0.021633349359035492,
-0.018372967839241028,
0.01456918939948082,
-0.008925038389861584,
0.035864196717739105,
-0.0148767726495862,
0.00509819108992815,
-0.00035852662404067814,
0.023950476199388504,
-0.002260736422613263,
0.006218306720256805,
0.01144209410995245,
0.0014789624838158488,
0.022474076598882675,
-0.020115939900279045,
0.006028630305081606,
0.006279823370277882,
0.014302617870271206,
-0.05372452735900879,
0.015573961660265923,
0.00872510951012373,
-0.0003508370718918741,
-0.020115939900279045,
-0.015871291980147362,
-0.01800386793911457,
-0.024893730878829956,
0.015276631340384483,
0.02019796147942543,
0.023335309699177742,
0.02815411239862442,
-0.0131440544500947,
-0.03818132355809212,
0.01649671047925949,
-0.013913012109696865,
-0.007566546089947224,
-0.03436729311943054,
-0.01588154397904873,
0.01335936225950718,
-0.014671717770397663,
-0.012272568419575691,
-0.021387282758951187
] | 2024-12-30 | 71 | 39734655 | [
"specific targeted therapies",
"Thyroid cancer treatment",
"BRAF",
"the introduction",
"e.g. BRAF"
] | [] | 0 | 10.1016/j.coemr.2024.100544
10.1016/S2213-8587(22)00035-3
10.1038/nrendo.2016.110
10.1016/j.amjsurg.2009.11.008
10.1093/bjsopen/zrab099
10.1210/jc.2005-2838
10.1210/er.2019-00007
10.1530/ERC-15-0555
10.1016/S0140-6736(14)60421-9
10.1056/NEJMoa1406470
10.1200/JCO.2012.48.4659
10.1200/JCO.2011.35.5040
10.1016/j.ejca.2018.10.002
10.1089/thy.2022.0115
10.1016/j.annonc.2021.12.014
10.1186/s40425-018-0378-y
10.1089/thy.2020.0322
10.1016/j.ctrv.2022.102372
10.1136/jclinpath-2020-207357
10.1016/j.immuni.2018.03.023
10.3389/fendo.2020.637826
10.1210/jc.2009-2564
10.1210/jc.2018-01167
10.1002/hed.25740
10.4132/jptm.2015.06.01
10.1089/thy.2011.0452
10.1677/ERC-08-0036
10.1089/thy.2020.0312
10.1210/jc.2011-3428
10.1007/s12094-014-1222-6
10.1038/s41573-018-0007-y
10.1530/ERC-17-0532
10.1007/s12032-023-02260-x
10.1038/s41467-021-26343-3
10.1530/ERC-17-0104
10.1016/j.ejso.2018.10.060
10.1210/clinem/dgaa701
10.1089/thy.2019.0604
10.1089/thy.2015.0289
10.3389/fimmu.2023.1325343
10.1038/nrclinonc.2018.9
10.1038/nrm.2016.87
10.1038/sj.bjc.6604965
10.1182/blood-2002-07-1956
10.1038/bjc.2012.468
10.1158/0008-5472.CAN-12-2325
10.1111/jcmm.14027
10.1038/nrclinonc.2018.29
10.1158/1078-0432.CCR-18-0693
10.1016/j.semcdb.2023.05.010
10.1016/j.it.2010.04.002
10.1371/journal.pone.0199740
10.1038/onc.2010.348
10.1158/1078-0432.CCR-18-0663
10.1007/s12022-010-9116-9
10.3389/fcell.2020.00766
10.1016/j.smim.2018.02.002
10.1210/clinem/dgab552
10.1172/jci.insight.157874
10.1155/2019/9095753
10.1200/JCO.19.02727
10.3390/cancers13133200
10.1002/cncr.34657
10.1530/ETJ-23-0144
10.1186/s12902-024-01555-y
10.1089/thy.2023.0573
10.1038/s41416-018-0296-2
10.1007/s10637-021-01088-4
10.1158/1078-0432.CCR-21-0903
10.3389/fgene.2020.00312
10.1172/JCI142030 | [
"Prete",
"Nucera"
] | [
"Human thyroid cancers preclinical and translational research program, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.",
"Human thyroid cancers preclinical and translational research program, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.\nBroad Institute of MIT and Harvard, Cambridge, MA, USA."
] | [
"39734655",
"35271818",
"27418023",
"20561605",
"34686878",
"16684830",
"31322645",
"27207700",
"24768112",
"25671254",
"24002501",
"22025146",
"30471649",
"35658604",
"35026411",
"29996921",
"33509020",
"35248904",
"33619218",
"29628290",
"33986723",
"20207826",
"30882858",
"30896061",
"26081823",
"22870901",
"18719091",
"32611231",
"22466343",
"25387566",
"30610226",
"29507047",
"38129369",
"34663816",
"28420659",
"30528043",
"33000173",
"32242507",
"26756227",
"38235146",
"29434333",
"27461391",
"19277038",
"12586633",
"23169339",
"23108136",
"30456891",
"29508855",
"30076136",
"37286406",
"20538542",
"29953504",
"20729915",
"30314969",
"20336393",
"32974337",
"29490888",
"34302727",
"35439170",
"31885948",
"32364844",
"34206867",
"36748723",
"38181007",
"38383419",
"38226606",
"30327563",
"33852104",
"34140403",
"32391048",
"33463538"
] | [] | 10.182327 | 4.483451 |
39723764 | 94 | Dual-targeted STAb-T cells secreting BCMA and CD19 T cell engagers for improved control of haematological cancers. | Despite recent advances in immunotherapy against B cell malignancies such as BCMA (B cell maturation antigen) and CD19-targeted treatments using soluble T cell-engaging (TCE) antibodies or chimeric antigen receptor T cells (CAR-T), there is still an important number of patients experiencing refractory/relapsed (R/R) disease. Approaches to avoid tumor-intrinsic mechanisms of resistance such as immune pressure-mediated antigen downmodulation, are being broadly investigated. These strategies include BCMA/CD19 dual-targeting therapies, which may be of particular interest to patients with B cell lymphoma and multiple myeloma, where a specific double-positive immature subpopulation is commonly associated with poor prognosis and poor response to current treatments. In fact, several clinical trials targeting both antigens through different strategies are currently underway. Here, based on the previously validated STAb (in situ secretion of T cell-redirecting bispecific antibodies) concept, we used two different engineering strategies (pool and co-transduction) to generate dual-targeted STAb-T cells simultaneously secreting BCMA TCE and CD19 TCE that outperformed single-targeted STAb-T cells in different | [
0.03525831550359726,
0.010779691860079765,
0.10155405104160309,
0.03409567475318909,
-0.0348033681511879,
0.009825569577515125,
-0.015177503228187561,
0.0504484549164772,
-0.028990168124437332,
-0.0004719274875242263,
0.0123088164255023,
-0.012409915216267109,
-0.025742359459400177,
0.017704980447888374,
0.025236865505576134,
-0.0036048151087015867,
0.051661644130945206,
-0.007121168542653322,
-0.00853655580431223,
0.05848583206534386,
0.010880791582167149,
0.0062649850733578205,
0.003753304248675704,
0.007967873476445675,
-0.011228319257497787,
-0.019196193665266037,
-0.019019270315766335,
0.011316780932247639,
-0.032452814280986786,
-0.029546214267611504,
0.047668229788541794,
-0.021572021767497063,
-0.023859389126300812,
-0.004859075881540775,
-0.025906646624207497,
0.030001159757375717,
0.01899399422109127,
-0.012049749493598938,
-0.0062649850733578205,
-0.0024042632430791855,
0.03917590528726578,
0.0025037825107574463,
0.017831355333328247,
0.05489681661128998,
-0.052975933998823166,
0.00933271087706089,
-0.028889069333672523,
-0.04054074361920357,
0.02384675107896328,
0.0040439642034471035,
-0.0184000376611948,
0.007727763149887323,
-0.038771506398916245,
0.028611047193408012,
-0.041728656738996506,
0.004186134785413742,
-0.04448360577225685,
0.003009278094395995,
0.00901045836508274,
0.011695902794599533,
-0.006994794588536024,
-0.016112670302391052,
0.00968655850738287,
-0.013976951129734516,
-0.0625297948718071,
0.011203045025467873,
-0.021192900836467743,
-0.022304991260170937,
-0.016453878954052925,
-0.013104971498250961,
0.00009369439067086205,
-0.02762533165514469,
0.025198953226208687,
0.03333742916584015,
0.0385187603533268,
0.01800827868282795,
0.0021831088233739138,
0.04999350756406784,
0.006321853492408991,
-0.0030535089317709208,
0.004483113531023264,
-0.008846172131597996,
0.05247043818235397,
-0.0505242794752121,
-0.015025855042040348,
0.010059361346065998,
0.009509635157883167,
0.000972289068158716,
-0.05484626442193985,
-0.0009304277482442558,
-0.006779958959668875,
-0.008612380363047123,
-0.04807262495160103,
0.04678361117839813,
-0.020497843623161316,
-0.01143051777034998,
-0.005765808280557394,
-0.07643092423677444,
0.022671474143862724,
0.041551731526851654,
0.04195613041520119,
-0.00259856297634542,
0.008612380363047123,
-0.007702488452196121,
0.05767704173922539,
-0.03439897298812866,
-0.008037379011511803,
0.003911271691322327,
0.018564322963356972,
0.01981542445719242,
0.042486898601055145,
-0.004811685532331467,
-0.003481600433588028,
0.016011571511626244,
0.0009343769052065909,
-0.08588369190692902,
-0.021913232281804085,
-0.024364884942770004,
0.007159080356359482,
0.03922645375132561,
-0.009730788879096508,
0.0521671399474144,
0.032174792140722275,
-0.024756643921136856,
-0.00393022783100605,
-0.024693457409739494,
0.08921996504068375,
-0.042764920741319656,
-0.046530865132808685,
-0.07956499606370926,
0.06576497107744217,
-0.010432164184749126,
0.016820363700389862,
-0.001834001042880118,
-0.07178036868572235,
0.0029176571406424046,
-0.00035384687362238765,
0.007727763149887323,
-0.029622038826346397,
-0.010109910741448402,
0.033261604607105255,
-0.002213122555986047,
-0.009610733948647976,
-0.00801842287182808,
-0.03341325372457504,
-0.05168692022562027,
0.006735728122293949,
0.0033520672004669905,
0.0015907313209027052,
0.020914878696203232,
-0.0682418942451477,
0.03182094544172287,
0.03685062378644943,
0.0029761050827801228,
-0.011828595772385597,
-0.06404628604650497,
-0.01583464816212654,
0.05818253755569458,
-0.017502782866358757,
-0.06278254836797714,
-0.027751704677939415,
-0.0030282342340797186,
-0.0016776133561506867,
-0.005781605374068022,
0.061266057193279266,
0.01626431941986084,
-0.001965113915503025,
0.032933034002780914,
-0.055857256054878235,
0.021786857396364212,
-0.009117876179516315,
-0.023707740008831024,
-0.08012104034423828,
-0.021685758605599403,
-0.0308352280408144,
0.0053645712323486805,
-0.0028639482334256172,
0.002968206536024809,
-0.023834114894270897,
-0.0302286334335804,
0.0020598943810909986,
0.004154541529715061,
0.012877498753368855,
-0.020485207438468933,
-0.00007241815910674632,
-0.008903040550649166,
0.0026822856161743402,
0.02909126877784729,
-0.010324746370315552,
-0.008271170780062675,
-0.005765808280557394,
0.02636159211397171,
0.06025506928563118,
0.0033552267123013735,
-0.005418280139565468,
-0.03563743457198143,
0.039706673473119736,
0.017667068168520927,
-0.028914345428347588,
-0.028636321425437927,
0.03134072199463844,
-0.03649677708745003,
0.0010267877951264381,
0.005152895115315914,
-0.028560496866703033,
0.008365951478481293,
0.000573421479202807,
0.03619347885251045,
-0.015796735882759094,
0.020839054137468338,
0.03207369148731232,
0.01860223524272442,
-0.020333558320999146,
0.009756064042448997,
-0.03154292330145836,
-0.016188494861125946,
-0.023000046610832214,
0.01577146165072918,
0.0016839320305734873,
0.03225061669945717,
0.006742046680301428,
0.004315668251365423,
0.022898947820067406,
0.03879678249359131,
-0.024251148104667664,
0.023947851732373238,
0.018526410683989525,
-0.04807262495160103,
-0.015695637091994286,
-0.024099498987197876,
-0.004985449835658073,
0.0007965503609739244,
0.01192337553948164,
-0.024251148104667664,
-0.007468696683645248,
-0.028307750821113586,
0.026841813698410988,
0.01258052047342062,
0.07304410636425018,
-0.03902425616979599,
-0.0037375076208263636,
0.00851128064095974,
0.056463852524757385,
-0.01876652240753174,
-0.038013264536857605,
0.004037645645439625,
-0.01184755191206932,
-0.0678880512714386,
0.013964314013719559,
-0.026538515463471413,
0.007936280220746994,
0.010141503997147083,
-0.021647846326231956,
-0.02128136157989502,
0.02172367088496685,
0.026437416672706604,
0.03442424535751343,
-0.017123661935329437,
0.0038828374817967415,
0.0058479513972997665,
-0.021635208278894424,
0.034348420798778534,
-0.027220934629440308,
-0.025881370529532433,
-0.04443305730819702,
0.025148402899503708,
-0.01812201552093029,
0.03371655195951462,
0.05429022014141083,
0.01958795264363289,
-0.012460464611649513,
0.027549507096409798,
0.02548961155116558,
-0.02744840830564499,
-0.040313269942998886,
-0.0002290526608703658,
-0.005832154769450426,
0.019954435527324677,
-0.013117609545588493,
0.0246176328510046,
-0.01833685114979744,
-0.01560717448592186,
-0.0012724270345643163,
-0.036370404064655304,
0.0013474614825099707,
0.005968006793409586,
-0.013913764618337154,
-0.021736308932304382,
0.008991502225399017,
-0.04410448670387268,
0.016403330489993095,
0.009288480505347252,
-0.03786161541938782,
-0.0545935183763504,
-0.015493438579142094,
-0.014330798760056496,
0.017806081101298332,
-0.035940732806921005,
-0.03212423995137215,
0.046530865132808685,
-0.03131544962525368,
-0.007323366589844227,
-0.020422019064426422,
-0.001133415731601417,
0.023770928382873535,
-0.010489032603800297,
-0.021875320002436638,
-0.037078097462654114,
0.021761583164334297,
0.03343852981925011,
0.011253594420850277,
-0.018690697848796844,
-0.0024816670920699835,
0.021736308932304382,
0.0065903980284929276,
-0.013913764618337154,
0.0027818051166832447,
-0.06278254836797714,
0.0015970499953255057,
-0.042764920741319656,
-0.003348907921463251,
-0.0035131939221173525,
-0.04976603388786316,
0.008359632454812527,
0.026664890348911285,
-0.03677479922771454,
-0.002800761256366968,
-0.030481381341814995,
0.016908826306462288,
-0.04367481544613838,
0.04359899088740349,
-0.026664890348911285,
0.06642211228609085,
-0.02516104094684124,
-0.01790717989206314,
-0.012807993218302727,
-0.01894344575703144,
-0.031846217811107635,
0.02843412384390831,
0.022949498146772385,
-0.011714858934283257,
0.03252863883972168,
-0.04251217469573021,
0.020169271156191826,
0.05049900338053703,
0.01244150847196579,
0.00406607985496521,
0.019524764269590378,
-0.008580787107348442,
0.02019454725086689,
0.03700227290391922,
-0.009269524365663528,
0.046252842992544174,
-0.030481381341814995,
0.0012874339008703828,
0.018867621198296547,
-0.0011879145167768002,
-0.04261327534914017,
-0.004963334184139967,
-0.01654234156012535,
-0.016226407140493393,
-0.0012716371566057205,
-0.0281561017036438,
0.014090687967836857,
0.0388726070523262,
0.06247925013303757,
0.019689051434397697,
0.011342056095600128,
-0.006028034258633852,
-0.013635742478072643,
0.013104971498250961,
0.03412094712257385,
-0.0031609267462044954,
0.02593192085623741,
-0.027928628027439117,
0.03819018602371216,
0.01817256398499012,
0.005835314281284809,
0.022734662517905235,
0.04370008781552315,
0.03275611251592636,
-0.03278138488531113,
-0.02810555137693882,
-0.04713745787739754,
-0.012738487683236599,
0.04091986268758774,
0.01567036099731922,
-0.03404512256383896,
-0.0728924572467804,
0.008473369292914867,
-0.002126240637153387,
-0.021875320002436638,
0.004890669137239456,
-0.0032130558975040913,
-0.013913764618337154,
0.036698974668979645,
-0.03237698972225189,
0.09609469771385193,
0.028282474726438522,
0.029622038826346397,
0.011815957725048065,
-0.01991652324795723,
-0.008125840686261654,
-0.06829244643449783,
0.01855168677866459,
0.007601389195770025,
0.0504484549164772,
0.009181062690913677,
0.028686871752142906,
-0.03776051476597786,
-0.02494620531797409,
0.03733084350824356,
0.041172612458467484,
0.02516104094684124,
-0.0008514440269209445,
0.013888489454984665,
-0.038392387330532074,
0.05550340935587883,
-0.0017297425074502826,
0.02412477508187294,
-0.004394651856273413,
-0.053784724324941635,
0.05353197827935219,
-0.032553911209106445,
0.005430917721241713,
-0.014217061921954155,
0.025906646624207497,
0.017919816076755524,
-0.011841232888400555,
-0.04028799384832382,
-0.023859389126300812,
0.07466168701648712,
-0.026563789695501328,
-0.03690117597579956,
-0.010261558927595615,
0.050777025520801544,
-0.057272642850875854,
0.015025855042040348,
-0.037684693932533264,
0.030860502272844315,
-0.03629457950592041,
-0.02353081665933132,
-0.029672587290406227,
-0.02455444633960724,
-0.020510481670498848,
0.02423851005733013,
-0.002830774988979101,
0.0031656657811254263,
-0.028838520869612694,
-0.02511049062013626,
0.015329152345657349,
-0.03657260164618492,
0.0056267972104251385,
0.011114583350718021,
-0.037128645926713943,
0.006558804772794247,
0.04781987890601158,
-0.06445068120956421,
0.012700575403869152,
0.017553333193063736,
0.060052867978811264,
-0.05434076860547066,
0.02843412384390831,
-0.030253907665610313,
-0.022279715165495872,
0.05550340935587883,
0.02281048521399498,
0.007146443240344524,
0.021053889766335487,
-0.04334624111652374,
0.023770928382873535,
0.004859075881540775,
-0.013736841268837452,
0.010577494278550148,
-0.02820665016770363,
0.03854403644800186,
0.04142535850405693,
-0.0029397725593298674,
0.03753304481506348,
0.01173381507396698,
-0.0001312116364715621,
0.01598629541695118,
-0.014735194854438305,
-0.02941983938217163,
0.019360478967428207,
0.014672008343040943,
-0.02052311785519123,
0.04296712204813957,
-0.017148936167359352,
0.008833534084260464,
0.021357186138629913,
-0.0171868484467268,
0.03414622321724892,
-0.012738487683236599,
-0.004757976625114679,
-0.03376710042357445,
0.005958528723567724,
-0.016517067328095436,
0.00043322547571733594,
0.025009391829371452,
0.004429404623806477,
0.016453878954052925,
0.0007325736223720014,
0.023429717868566513,
0.04731438308954239,
0.032503362745046616,
0.027195660397410393,
0.03508139029145241,
0.022292353212833405,
0.012864861637353897,
-0.019739599898457527,
-0.03169456869363785,
0.01636541821062565,
-0.035056114196777344,
-0.023606641218066216,
-0.012207717634737492,
-0.04840119928121567,
-0.02483246847987175,
-0.004053442273288965,
0.004069238901138306,
0.00019933505973313004,
0.012150849215686321,
-0.02024509571492672,
0.035005565732717514,
0.02734730765223503,
-0.016390692442655563,
-0.03811436519026756,
-0.04081876575946808,
-0.048830870538949966,
-0.030708853155374527,
0.009503316134214401,
-0.004037645645439625,
-0.0037975353188812733,
0.026993460953235626,
0.0009327972074970603,
-0.028585772961378098,
-0.023480268195271492,
0.041400086134672165,
-0.029546214267611504,
-0.06020451709628105,
0.014634096063673496,
-0.01353464275598526,
0.0209022406488657,
0.017831355333328247,
-0.019891249015927315,
0.028080277144908905,
0.0036648425739258528,
0.0068241897970438,
0.010836560279130936,
-0.0004632392665371299,
0.03093632683157921,
-0.024187961593270302,
0.01904454454779625,
-0.01812201552093029,
0.017009925097227097,
-0.04890669137239456,
-0.011664309538900852,
-0.032553911209106445,
0.01487420592457056,
-0.03093632683157921,
-0.018084103241562843,
-0.030380282551050186,
0.02287367358803749,
-0.04390228912234306,
0.0351572148501873,
0.0272967591881752,
-0.025906646624207497,
-0.0009343769052065909,
-0.04797152802348137,
0.03285720944404602,
-0.009345348924398422,
0.026538515463471413,
-0.021458284929394722,
-0.008618698455393314,
0.035334136337041855,
0.02636159211397171,
-0.003838606644421816,
-0.0021831088233739138,
-0.011885464191436768,
-0.0071085309609770775,
-0.018033552914857864,
-0.01845058798789978,
-0.01942366547882557,
0.04134953394532204,
-0.014545634388923645,
0.010350021533668041,
-0.04190557822585106,
-0.012896454893052578,
-0.03995942324399948,
-0.001048903213813901,
0.006817871239036322,
-0.020434657111763954,
0.02706928551197052,
0.017389046028256416,
0.005058114882558584,
0.03194731846451759,
0.003238330828025937,
-0.0019319407874718308,
-0.053026482462882996,
-0.004663196392357349,
0.030355006456375122,
-0.016403330489993095,
-0.018867621198296547,
-0.016024207696318626,
-0.02396048791706562,
0.03753304481506348,
0.009351667016744614,
-0.01636541821062565,
0.0021230813581496477,
-0.00019528713892214,
0.04402866214513779,
0.04228470101952553,
-0.029293466359376907,
-0.00020535755902528763,
0.002824456198140979,
0.00713380565866828,
-0.026437416672706604,
0.002352133858948946,
0.01976487599313259,
0.017641793936491013,
-0.027701156213879585,
-0.0003735928039532155,
-0.013496730476617813,
-0.011746452189981937,
0.01567036099731922,
-0.030102258548140526,
-0.014975305646657944,
-0.012978597544133663,
0.04337151721119881,
-0.0012597896857187152,
-0.014343435876071453,
-0.017995640635490417,
-0.016504429280757904,
0.035763807594776154,
-0.02078850381076336,
-0.03955502435564995,
0.05037263035774231,
0.00525399437174201,
-0.0001260776916751638,
-0.004764295648783445,
-0.01252365205436945,
0.02068740501999855,
0.007784631103277206,
-0.009509635157883167,
0.014115963131189346,
-0.025717085227370262,
0.002236817730590701,
0.005127620417624712,
0.002352133858948946,
-0.021218175068497658,
-0.025906646624207497,
0.005437236279249191,
0.06298474222421646,
-0.002772327046841383,
0.02024509571492672,
-0.008764028549194336,
-0.004085035994648933,
-0.00908628199249506,
0.04162755608558655,
0.05429022014141083,
-0.0463792160153389,
0.045545149594545364,
-0.012207717634737492,
0.0014240756863728166,
-0.01179068349301815,
-0.0027059807907789946,
0.004697949159890413,
-0.021483561024069786,
0.012542608194053173,
0.003781738458201289,
0.08371005952358246,
-0.02062421850860119,
0.009212655946612358,
0.008997820317745209,
-0.0043030306696891785,
0.02123081311583519,
0.013888489454984665,
-0.009888756088912487,
-0.03553633764386177,
0.003939705900847912,
-0.01784399151802063,
0.0016997287748381495,
-0.02369510382413864,
-0.0744594931602478,
-0.003247808897867799,
-0.00960441492497921,
-0.004062920343130827,
-0.00981925055384636,
0.0032414901070296764,
-0.0030377123039215803,
0.02489565499126911,
-0.029596762731671333,
-0.006565123330801725,
-0.02096542716026306,
0.01975223794579506,
-0.022898947820067406,
-0.0025559118948876858,
0.007955236360430717,
-0.027145110070705414,
-0.023050596937537193,
0.03652205318212509,
-0.010192053392529488,
0.023442355915904045,
0.008384907618165016,
0.016466517001390457,
-0.017881903797388077,
-0.02198905497789383,
0.0062049576081335545,
0.029723137617111206,
0.04152645915746689,
-0.018817070871591568,
0.0027533709071576595,
-0.02674071304500103,
-0.04807262495160103,
0.0006662273081019521,
-0.020396744832396507,
-0.016251681372523308,
0.06505727767944336,
-0.0011270970571786165,
-0.014912118203938007,
-0.005140257533639669,
0.013736841268837452,
-0.03209896758198738,
-0.0006709663430228829,
0.052975933998823166,
0.019031906500458717,
-0.04071766510605812,
0.049740761518478394,
-0.011778046377003193,
-0.012176123447716236,
-0.006410315167158842,
-0.010021449066698551,
-0.022772574797272682,
-0.029596762731671333,
0.004328305367380381,
0.04127370938658714,
-0.0054625109769403934,
-0.033211056143045425,
-0.007929961197078228,
-0.010545901022851467,
0.0215088352560997,
-0.0401616208255291,
-0.031618744134902954,
0.007399190682917833,
-0.0027912831865251064,
0.00966128334403038,
0.0272967591881752,
0.0318714939057827,
-0.007696169428527355,
-0.017338497564196587,
0.02073795348405838,
0.010438483208417892,
-0.010166779160499573,
-0.003544787410646677,
0.0029539894312620163,
-0.04546932503581047,
0.018652785569429398,
0.02532532624900341,
-0.04104623571038246,
-0.008656610734760761,
-0.021736308932304382,
0.00801842287182808,
-0.012631069868803024,
-0.005522538907825947,
-0.03432314842939377,
0.022785210981965065,
-0.0010876052547246218,
0.026007745414972305,
0.006596716586500406,
0.024920929223299026,
-0.02641214244067669,
-0.017212122678756714,
0.019891249015927315,
-0.02613411843776703,
-0.013635742478072643,
0.012485739775002003,
-0.0026475328486412764,
-0.010229965671896935,
-0.015594537369906902,
0.024642907083034515,
0.014419260434806347,
0.007317048031836748,
-0.017148936167359352,
0.01567036099731922,
-0.017768168821930885,
0.015164866112172604,
0.016782451421022415,
0.01659289188683033,
-0.017287947237491608,
-0.026285767555236816,
-0.00473586143925786,
0.030481381341814995,
-0.023341257125139236,
0.0073675974272191525,
-0.0015314935008063912,
0.008195346221327782,
0.019726963713765144,
-0.0963979959487915,
-0.018576961010694504,
-0.008770347572863102,
-0.000874349323567003,
-0.02641214244067669,
0.02527477592229843,
-0.014444534666836262,
-0.027852803468704224,
-0.009951943531632423,
-0.015645086765289307,
-0.0023884663823992014,
-0.016251681372523308,
0.006937926169484854,
-0.014924755319952965,
0.0021451967768371105,
-0.005933254025876522,
-0.0039807772263884544,
-0.021862681955099106,
0.0020693724509328604,
0.015455526299774647,
0.0092000188305974,
0.032933034002780914,
-0.02220389060676098,
0.048931967467069626,
-0.011032439768314362,
-0.007929961197078228,
-0.010552219115197659,
-0.006148089654743671,
-0.052369337528944016,
-0.04364953935146332,
0.012953323312103748,
0.019714325666427612,
-0.029116543009877205,
0.0447363555431366,
-0.013281894847750664,
-0.03331215679645538,
0.01708574965596199,
0.019284654408693314,
0.018678059801459312,
0.006508254911750555,
0.006811552215367556,
0.011468430049717426,
0.020497843623161316,
0.0032951990142464638,
-0.04236052557826042,
-0.013774753548204899,
-0.034955017268657684,
-0.008852490223944187,
0.007771993987262249,
-0.030430831015110016,
0.0019682731945067644,
-0.05140889436006546,
-0.03672425076365471,
0.01725003495812416,
0.004028167575597763,
-0.045924268662929535,
-0.013408268801867962,
0.04147590696811676,
-0.0021594136487692595,
0.005178169813007116,
-0.019069818779826164,
0.02542642503976822,
0.04440778121352196,
-0.013471456244587898,
0.00807529129087925,
-0.022229166701436043,
-0.012485739775002003,
0.05181329324841499,
-0.04407921060919762,
0.036269303411245346,
-0.008094247430562973,
0.03503084182739258,
-0.04251217469573021,
0.00954754650592804,
0.011367331258952618,
-0.005547813605517149,
-0.024213235825300217,
-0.013610467314720154,
-0.004138744901865721,
0.022418726235628128,
-0.01616322062909603,
0.004097673110663891,
0.0055256979539990425,
0.023808840662240982,
-0.013939039781689644,
0.000547356903553009,
-0.0073675974272191525,
0.036976996809244156,
0.010849198326468468,
0.012719531543552876,
-0.006065946538001299,
-0.02356872893869877,
-0.010059361346065998,
0.004404129926115274,
0.006223913747817278,
-0.013471456244587898,
-0.02537587657570839,
-0.00661567272618413,
-0.0007211209740489721,
-0.009553865529596806,
0.05322868004441261,
-0.004697949159890413,
-0.000301322725135833,
-0.018564322963356972,
-0.014406622387468815,
-0.02428906038403511,
0.012479420751333237,
0.003544787410646677,
0.023391805589199066,
-0.010280515067279339,
0.033211056143045425,
-0.009806613437831402,
0.005986962933093309,
-0.017641793936491013,
0.0058479513972997665,
0.0009091021493077278,
0.03874623402953148,
-0.026285767555236816,
0.008138477802276611,
0.02631104178726673,
0.06672541052103043,
0.02231762744486332,
-0.006931607611477375,
-0.03591545671224594,
0.005648912396281958,
-0.0010236285161226988,
0.030430831015110016,
0.04999350756406784,
-0.004606327973306179,
0.016504429280757904,
-0.004767454694956541,
0.03285720944404602,
-0.02543906308710575,
-0.03235171362757683,
0.011481067165732384,
0.0484517477452755,
-0.011120901443064213,
0.03854403644800186,
0.011973925866186619,
0.01004672423005104,
0.014217061921954155,
-0.025679172948002815,
-0.03604183346033096,
-0.0030456106178462505,
0.028914345428347588,
-0.019954435527324677,
-0.03111325018107891,
0.02116762474179268,
0.015253327786922455,
-0.002431117696687579,
-0.01642860472202301,
0.03998469561338425,
0.0177934430539608,
0.048173725605010986,
0.008258533664047718,
0.034525346010923386,
0.025729723274707794,
-0.01703519932925701,
-0.015556625090539455,
0.0071085309609770775,
-0.050953950732946396,
0.057929787784814835,
-0.003825969295576215,
-0.013243983499705791,
-0.007974192500114441,
-0.026159394532442093,
-0.0034752818755805492,
-0.0044483607634902,
0.005563610233366489,
-0.007614026311784983,
0.007727763149887323,
-0.047188010066747665,
0.04981658607721329,
-0.020055536180734634,
-0.03995942324399948,
-0.0007586381980217993,
0.013509368523955345,
-0.0002669648383744061,
0.02762533165514469,
0.03583963215351105,
0.008909358642995358,
0.009117876179516315,
0.012100299820303917,
0.027423132210969925,
0.01626431941986084,
-0.03252863883972168,
0.009263205341994762,
0.0018055668333545327,
0.021243449300527573,
-0.023872027173638344,
-0.0028718465473502874,
-0.017553333193063736,
0.031618744134902954,
0.041779205203056335,
0.027701156213879585,
-0.018905533477663994,
-0.01162007823586464,
0.023063233122229576,
-0.03538468852639198,
-0.048173725605010986,
-0.03171984478831291,
0.02445334568619728,
0.03338798135519028,
-0.010173097252845764,
-0.04225942865014076,
0.015910472720861435,
0.020598942413926125,
-0.05120669677853584,
-0.020649492740631104,
0.06834299862384796,
0.0030298137571662664,
0.015847284346818924,
-0.030683578923344612,
0.010817604139447212,
0.03166929632425308,
-0.011196726001799107,
-0.0009233191958628595,
-0.037735242396593094,
-0.029445115476846695,
0.010387932881712914,
-0.023859389126300812,
-0.039150629192590714,
0.005336137022823095,
-0.001532283378764987,
0.0008285387884825468,
-0.008283807896077633,
0.04415503516793251,
0.0065903980284929276,
-0.021850043907761574,
0.008429137989878654,
-0.00960441492497921,
0.051383621990680695,
0.027372583746910095,
0.02570444718003273,
0.0022257601376622915,
0.011695902794599533,
0.00022964504023548216,
-0.031846217811107635,
-0.0031609267462044954,
-0.01616322062909603,
0.06116496026515961,
0.04124843701720238,
-0.03657260164618492,
-0.008372269570827484,
-0.014040138572454453,
-0.0031893609557300806,
0.03760886937379837,
-0.018475862219929695,
0.008340676315128803,
-0.007569795474410057,
-0.012018156237900257,
0.003358385991305113,
-0.0019161440432071686,
0.0339440256357193,
0.03998469561338425,
0.003301517805084586,
-0.01652970351278782,
0.011133539490401745,
0.0413748100399971,
0.00034970021806657314,
0.01932256668806076,
-0.008151115849614143,
0.005611000582575798,
0.037785790860652924,
0.0027407335583120584,
0.0028197173960506916,
0.0066851782612502575,
-0.03247808665037155,
0.012011837214231491,
0.005007565021514893,
-0.005156054627150297,
0.0019477375317364931,
-0.013850578106939793,
0.0051465765573084354,
0.022848397493362427,
-0.016504429280757904,
0.021319273859262466,
-0.0405912920832634,
-0.016087396070361137,
-0.0014540895354002714,
-0.001269267755560577,
0.01604948379099369,
-0.039428651332855225,
0.003677479922771454,
0.014987942762672901,
0.004350421018898487,
-0.018159927800297737,
-0.02526213973760605,
0.01877915859222412,
-0.026538515463471413,
-0.010849198326468468,
0.018488498404622078,
-0.02527477592229843,
0.007234904915094376,
-0.021306637674570084,
-0.017123661935329437,
-0.021812131628394127,
-0.01154425460845232,
0.00221628206782043,
-0.006893695332109928,
-0.014608820900321007,
0.0326550118625164,
-0.016820363700389862,
-0.010893428698182106,
0.006761002819985151,
-0.017528057098388672,
0.0039870962500572205,
-0.04228470101952553,
0.042916569858789444,
-0.02701873704791069,
-0.04253745079040527,
0.02531268820166588,
0.007462377659976482,
0.0021167625673115253,
-0.0018908692291006446,
-0.007070618681609631,
0.019663777202367783,
0.04205722734332085,
0.015695637091994286,
-0.0136483795940876,
0.007140124216675758,
-0.00046837321133352816,
-0.006729409098625183,
0.006315534934401512,
-0.032604463398456573,
-0.0006812342326156795,
-0.006735728122293949,
-0.008587105199694633,
-0.020156634971499443,
-0.01669399067759514,
0.024326972663402557,
-0.014368711039423943,
0.006779958959668875,
-0.006773640401661396,
0.03543523699045181,
0.003519512712955475,
0.011259913444519043,
-0.006571441888809204,
0.016491791233420372,
-0.008138477802276611,
-0.007418146822601557,
-0.014482446946203709,
0.003620611736550927,
0.02205224335193634,
0.02198905497789383,
0.017439596354961395,
0.004410448484122753,
0.0023426557891070843,
-0.03214951604604721,
-0.00152833410538733,
0.05889023095369339,
-0.03983304649591446,
-0.04397810995578766,
0.00856814906001091,
-0.0013822143664583564,
-0.016302231699228287,
0.009054688736796379,
0.019082456827163696,
0.0006950563401915133,
-0.0007614026544615626,
0.00916842557489872,
0.02947038970887661,
0.010773373767733574,
0.002868687268346548,
0.0011966027086600661,
0.016074758023023605,
-0.0229747723788023,
0.009345348924398422,
0.008479687385261059,
0.0002736784517765045,
-0.006501936353743076,
0.026235219091176987,
-0.018147289752960205,
0.00941485445946455,
-0.023151695728302002,
-0.0024769280571490526,
0.05777813866734505,
0.009749745018780231,
0.003560584271326661,
0.025780271738767624,
-0.027220934629440308,
-0.01014782302081585,
-0.02233026549220085,
-0.014457172714173794,
-0.00856814906001091,
-0.032301165163517,
-0.02701873704791069,
-0.03624403104186058,
0.010457439348101616,
0.00728545431047678,
-0.01118408888578415,
-0.010015130043029785,
0.03674952685832977,
0.027574781328439713,
-0.02407422475516796,
0.020068172365427017,
0.010223647579550743,
0.017654431983828545,
-0.0050486368127167225,
0.020106084644794464,
-0.06672541052103043,
-0.001210029935464263,
0.0351572148501873,
-0.005092867650091648,
-0.0026364752557128668,
0.013989589177072048,
0.005421439651399851,
0.03027918189764023,
0.008226939477026463,
0.008732435293495655,
-0.009895075112581253,
0.0023789883125573397,
-0.05499791353940964,
0.05135834589600563,
-0.02172367088496685,
-0.0015062186866998672,
-0.016668714582920074,
-0.02440279722213745,
-0.04830009862780571,
-0.01222667284309864,
0.00417665671557188,
-0.017376409843564034,
0.009162106551229954,
-0.004006051924079657,
-0.02335389330983162,
-0.0013182376278564334,
0.014115963131189346,
0.0048464382998645306,
-0.02483246847987175,
0.010710186325013638,
0.009218974970281124,
0.007481333799660206,
0.012877498753368855,
0.0016902507049962878,
-0.03207369148731232,
0.008081610314548016,
-0.011398924514651299,
-0.009490679018199444,
-0.05262208357453346,
-0.015493438579142094,
0.009408535435795784,
0.002211543032899499,
0.042436350136995316,
0.02374565228819847,
0.02216598019003868,
-0.025135764852166176,
-0.008713479153811932,
0.0014698862796649337,
0.028509948402643204,
-0.00914315041154623,
0.003832288086414337,
0.02586873434484005,
-0.04028799384832382,
0.004833801183849573,
-0.01937311701476574,
0.01075441762804985,
-0.035182490944862366,
0.00901045836508274,
0.001095503568649292,
0.02838357351720333,
-0.03897370398044586,
-0.01173381507396698,
0.011778046377003193,
0.028686871752142906,
0.015569262206554413,
0.018311575055122375,
0.002875005826354027,
-0.013875852338969707,
-0.01244150847196579,
-0.0034152541775256395,
0.014330798760056496,
0.006874739192426205,
0.016554979607462883,
0.005282428581267595,
-0.007632982451468706,
-0.012479420751333237,
0.015430251136422157,
0.023063233122229576,
0.008764028549194336,
-0.010116229765117168,
-0.030152808874845505,
0.0368000753223896,
0.006931607611477375,
-0.0026506921276450157,
0.018576961010694504,
0.0339440256357193,
-0.006956882309168577,
-0.019663777202367783,
0.026058295741677284,
0.01386321522295475,
-0.0008751391433179379,
-0.023505542427301407,
-0.015341789461672306,
0.011038758791983128,
-0.018741246312856674,
-0.007354959845542908,
-0.009692876599729061,
-0.03624403104186058,
-0.012574201449751854,
0.02871214598417282,
-0.012909092009067535,
-0.016883550211787224,
-0.005699462257325649,
-0.020839054137468338,
0.00996458064764738,
0.005396164953708649,
-0.042158327996730804,
-0.05974957346916199,
-0.011013483628630638,
0.024137411266565323,
-0.01996707357466221,
0.016441242769360542,
-0.027852803468704224,
0.026513241231441498,
0.0533803291618824,
-0.005516219884157181,
-0.012270904146134853,
0.041501183062791824,
0.0047232238575816154,
0.000980187440291047,
0.008751391433179379,
0.024301698431372643,
0.013901127502322197,
-0.03171984478831291,
-0.020396744832396507,
0.014229699037969112,
-0.006062787026166916,
0.02853522263467312,
-0.002427958184853196,
0.0209022406488657,
0.028990168124437332,
-0.009970899671316147,
0.014659370295703411,
-0.01478574424982071,
-0.02106652595102787,
0.026437416672706604,
0.0006583289359696209,
-0.00624918844550848,
-0.011778046377003193,
-0.029975885525345802,
-0.006419793237000704,
0.024314334616065025,
0.01685827597975731,
0.003952343016862869,
0.005471989046782255,
0.0036522052250802517,
0.040136344730854034,
0.007279135752469301,
0.006347128190100193,
0.029293466359376907,
0.04114733636379242,
-0.019006632268428802,
-0.010103591717779636,
-0.0009201598586514592,
-0.026892362162470818,
-0.033261604607105255,
-0.015796735882759094,
0.007386553566902876,
-0.008416500873863697,
0.0027154588606208563,
0.022797849029302597,
0.008207983337342739,
-0.0004371746617835015,
-0.002037778962403536,
0.0013522005174309015,
-0.004419926553964615,
-0.01405277568846941,
0.008410181850194931,
-0.028990168124437332,
-0.009882437996566296,
-0.022026967257261276,
-0.016062119975686073,
0.00002848348958650604,
0.008233258500695229,
-0.02460499480366707,
0.005835314281284809,
0.012106617912650108,
0.013597830198705196,
0.006729409098625183,
-0.017641793936491013,
-0.029647313058376312,
0.0050454773008823395,
-0.029622038826346397,
0.0271198358386755,
-0.0004920682986266911,
-0.016175856813788414,
-0.03232644125819206,
-0.02303795889019966,
-0.01416651252657175,
0.017528057098388672,
-0.025881370529532433,
-0.010558538138866425,
0.0026949229650199413,
0.010280515067279339,
0.007178036496043205,
0.022077517583966255,
-0.0008056334918364882,
0.0011002426035702229,
-0.016630802303552628,
0.01800827868282795,
-0.016125308349728584,
0.04642976447939873,
-0.025022029876708984,
0.0007914164452813566,
-0.00021779749658890069,
-0.008574468083679676,
-0.006031193770468235,
-0.02139509841799736,
-0.021976418793201447,
0.015733549371361732,
-0.023644553497433662,
0.020876966416835785,
0.002615939360111952,
0.01050798874348402,
-0.010868154466152191,
0.022835761308670044,
-0.03864513337612152,
0.008467050269246101,
0.026209942996501923,
0.008182709105312824,
0.034904465079307556,
0.040363818407058716,
-0.01616322062909603,
0.0032762428745627403,
-0.006495617795735598,
0.03268028795719147,
-0.01735113374888897,
-0.004840119741857052,
0.04018689692020416,
-0.01680772565305233,
-0.016517067328095436,
0.016630802303552628,
-0.0032762428745627403,
-0.011493705213069916,
0.00045178664731793106,
-0.02658906579017639,
-0.030304457992315292,
0.002729675965383649,
-0.0077909501269459724,
0.0260835699737072,
-0.015341789461672306,
0.02427642233669758,
-0.012188761495053768,
-0.005806880071759224,
-0.026285767555236816,
0.028560496866703033,
-0.02613411843776703,
-0.04842647165060043,
-0.011228319257497787,
-0.013976951129734516,
-0.027650605887174606,
-0.0009557025041431189,
0.013117609545588493,
0.02014399692416191,
0.02281048521399498,
0.01520277839154005,
-0.008745072409510612,
0.020042898133397102,
-0.03760886937379837,
-0.017831355333328247,
0.027650605887174606,
-0.017869267612695694,
0.01915828138589859,
0.026917636394500732,
0.020775865763425827,
0.004154541529715061,
0.024491257965564728,
0.012479420751333237,
-0.013913764618337154,
0.011335737071931362,
-0.034348420798778534,
-0.0026206783950328827,
-0.005004405975341797,
0.008637654595077038,
0.08750128000974655,
-0.03235171362757683,
-0.0008696102886460721,
0.02460499480366707,
-0.0037596230395138264,
-0.03060775436460972,
0.01652970351278782,
-0.0034721223637461662,
-0.002236817730590701,
-0.027953902259469032,
0.025729723274707794,
0.024870380759239197,
0.05221768841147423,
0.03149237111210823,
0.042385801672935486,
-0.01626431941986084,
0.01599893346428871,
0.02275993674993515,
0.009522272273898125,
-0.029596762731671333,
-0.009433810599148273,
0.0215088352560997,
-0.021976418793201447,
0.025717085227370262,
-0.013382994569838047,
-0.0188297089189291,
-0.008915677666664124,
-0.008909358642995358,
0.0014074891805648804,
-0.03313523158431053,
-0.011613760143518448,
-0.002576447557657957,
0.030203359201550484,
-0.033261604607105255,
0.02810555137693882,
0.0065903980284929276,
-0.005873226094990969,
-0.005519379395991564,
0.00728545431047678,
-0.00245481263846159,
0.00006264392868615687,
-0.0018940286245197058,
0.006451386958360672,
-0.0010907645337283611,
-0.00719067407771945,
0.015796735882759094,
-0.006223913747817278,
0.011367331258952618,
0.0036648425739258528,
-0.015139590948820114,
0.007196992635726929,
0.003753304248675704,
0.024845106527209282,
-0.006710453424602747,
-0.005825836211442947,
-0.016908826306462288,
0.023341257125139236,
-0.0130417849868536,
-0.007165399380028248,
-0.020548393949866295,
-0.021913232281804085,
0.013256620615720749,
0.016517067328095436,
0.0011626397026702762,
0.023619279265403748
] | 2024-12-26 | 1 | 39723764 | [
"B cell lymphoma",
"B cell malignancies",
"CD19 TCE",
"BCMA TCE",
"different strategies",
"(B cell maturation antigen",
"T cell-redirecting bispecific antibodies",
"dual-targeted STAb-T cells",
"single-targeted STAb-T cells",
"poor prognosis",
"poor response",
"BCMA",
"several clinical trials",
"soluble T cell-engaging (TCE",
"CD19-targeted treatments",
"current treatments",
"patients",
"multiple myeloma",
"immune pressure-mediated antigen downmodulation",
"situ secretion",
"particular interest",
"two different engineering strategies",
"recent advances",
"resistance",
"co",
"-",
"transduction",
"pool",
"tumor-intrinsic mechanisms",
"BCMA/CD19 dual-targeting therapies"
] | [
"Bispecific antibodies",
"STAb-T immunotherapy",
"T cell engagers",
"dual-targeting immunotherapy",
"haematological malignancies"
] | 0 | 10.1080/2162402X.2024.2444701 | [
"Velasco-Sidro",
"Arroyo-Ródenas",
"Díez-Alonso",
"Ramírez-Fernández",
"Álvarez-Vallina"
] | [
"Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.\nImmuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain.\nH12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.",
"Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.\nImmuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain.\nH12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.",
"Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.\nImmuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain.\nH12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.",
"Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.\nImmuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain.\nH12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.",
"Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.\nImmuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain.\nH12O-CNIO Cancer Immunotherapy Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain."
] | [
"39723764"
] | [] | 5.273784 | 6.075217 |
39722028 | 95 | Current and future immunotherapy for breast cancer. | Substantial therapeutic advancement has been made in the field of immunotherapy in breast cancer. The immune checkpoint inhibitor pembrolizumab in combination with chemotherapy received FDA approval for both PD-L1 positive metastatic and early-stage triple-negative breast cancer, while ongoing clinical trials seek to expand the current treatment landscape for immune checkpoint inhibitors in hormone receptor positive and HER2 positive breast cancer. Antibody drug conjugates are FDA approved for triple negative and HER2+ disease, and are being studied in combination with immune checkpoint inhibitors. Vaccines and bispecific antibodies are areas of active research. Studies of cellular therapies such as tumor infiltrating lymphocytes, chimeric antigen receptor-T cells and T cell receptor engineered cells are promising and ongoing. This review provides an update of recent major clinical trials of immunotherapy in breast cancer and discusses future directions in the treatment of breast cancer. | [
0.020130880177021027,
-0.04167334362864494,
0.031771183013916016,
0.08444224298000336,
-0.019277608022093773,
-0.00527764018625021,
0.023364882916212082,
0.03748072683811188,
0.01766587421298027,
0.01497964933514595,
0.007342346012592316,
-0.005282907281070948,
-0.026841172948479652,
0.003463122295215726,
0.0012074840487912297,
0.005382982548326254,
0.037270043045282364,
0.017149697989225388,
0.022901376709342003,
0.03575311601161957,
0.02064705640077591,
-0.030675625428557396,
-0.03478396683931351,
-0.009212168864905834,
-0.04807814583182335,
-0.012788533233106136,
-0.020689193159341812,
-0.0213001761585474,
-0.01751839555799961,
0.004237386863678694,
0.020057139918208122,
-0.01008124090731144,
-0.03615341708064079,
0.013241504319012165,
-0.03360413759946823,
0.011113593354821205,
-0.0034236188512295485,
0.034741830080747604,
-0.013399518094956875,
0.027220403775572777,
0.00836943183094263,
0.008311493322253227,
-0.0014761064667254686,
0.047235406935214996,
-0.07475076615810394,
0.023554498329758644,
-0.008232486434280872,
-0.05123840644955635,
-0.032087210565805435,
-0.030696693807840347,
-0.015337812714278698,
0.01669672690331936,
-0.052418239414691925,
0.039334747940301895,
-0.023238472640514374,
0.03392016142606735,
-0.014695226214826107,
-0.007073723245412111,
-0.006273123435676098,
-0.01970951072871685,
-0.0031233939807862043,
-0.0196884423494339,
0.04496001824736595,
-0.052418239414691925,
-0.06160407140851021,
0.006689224857836962,
-0.030823104083538055,
-0.03392016142606735,
0.02142658829689026,
-0.03811277821660042,
0.05187046155333519,
0.006726094521582127,
-0.006599683780223131,
0.04837310314178467,
0.005641070660203695,
0.02220611833035946,
0.027557499706745148,
0.04304279014468193,
-0.0037212104070931673,
-0.012009002268314362,
0.024966083467006683,
-0.004943178966641426,
0.007489824667572975,
0.001338503323495388,
-0.030696693807840347,
0.017276108264923096,
0.00405830517411232,
-0.005032720044255257,
-0.06451151520013809,
-0.021869024261832237,
-0.012893876060843468,
0.008890874683856964,
-0.014716294594109058,
0.04304279014468193,
-0.029200835153460503,
-0.004577115178108215,
-0.0021397618111222982,
-0.0488787442445755,
-0.0017012752359732985,
0.038681626319885254,
0.024039072915911674,
0.023217404261231422,
-0.03503679111599922,
-0.010708026587963104,
0.03794423118233681,
-0.028463441878557205,
-0.019983399659395218,
-0.018519144505262375,
0.034299395978450775,
0.002280656946823001,
0.012388233095407486,
-0.004677189979702234,
-0.02536638267338276,
0.05026926100254059,
-0.010966114699840546,
-0.05309242755174637,
0.008332561701536179,
0.004719327203929424,
0.008432636968791485,
0.025661339983344078,
-0.03954543173313141,
0.046771902590990067,
0.023596635088324547,
-0.027051856741309166,
0.025113562121987343,
-0.04588702693581581,
0.049721479415893555,
-0.01874036341905594,
-0.006926244590431452,
-0.029116561636328697,
-0.018045105040073395,
0.004598183557391167,
0.05296601727604866,
-0.006146712694317102,
-0.04026176035404205,
-0.030654557049274445,
0.017402518540620804,
0.020889341831207275,
-0.03990359604358673,
-0.0026664724573493004,
0.05330311506986618,
0.00018039837596006691,
-0.0018632387509569526,
-0.028294892981648445,
-0.05334525182843208,
-0.06880947202444077,
-0.004163647536188364,
-0.007784782908856869,
0.016759932041168213,
0.04047244414687157,
-0.031434088945388794,
0.02254321426153183,
0.05658978596329689,
0.019667373970150948,
-0.027831388637423515,
0.009954830631613731,
-0.012356630526483059,
0.09893731772899628,
-0.02157406695187092,
-0.03739645332098007,
-0.058233123272657394,
0.006568081211298704,
-0.014695226214826107,
-0.019614702090620995,
0.0315815694630146,
-0.009185832925140858,
-0.011408551596105099,
0.015411552041769028,
-0.052881743758916855,
0.005116993561387062,
0.014389733783900738,
-0.014463473111391068,
-0.029853956773877144,
-0.004872072953730822,
-0.021974366158246994,
-0.0015498459106311202,
0.02614591456949711,
0.028969082981348038,
-0.012651588767766953,
-0.023259541019797325,
-0.006004501134157181,
-0.0040188017301261425,
0.000282613153103739,
0.039482228457927704,
-0.013030820526182652,
0.031096994876861572,
-0.00043289028690196574,
0.05389302968978882,
-0.061266977339982986,
-0.02271176129579544,
0.010976648889482021,
-0.00891721062362194,
0.011461222544312477,
0.029074424877762794,
0.013999967835843563,
-0.026904378086328506,
0.005583132617175579,
0.016633521765470505,
0.0009632220026105642,
-0.008432636968791485,
0.053977303206920624,
-0.017549997195601463,
-0.03339345380663872,
-0.013367915526032448,
-0.04934224858880043,
-0.04483360797166824,
-0.015264073386788368,
0.011218936182558537,
-0.000020677505744970404,
-0.00728967459872365,
0.016517644748091698,
-0.01906692422926426,
0.026883309707045555,
-0.0031049589160829782,
-0.0015998834278434515,
-0.007768981624394655,
-0.006531211547553539,
-0.010060172528028488,
0.038386669009923935,
0.03735431656241417,
0.017149697989225388,
-0.005185465794056654,
0.018856240436434746,
0.00519599998369813,
-0.027557499706745148,
0.02145818993449211,
0.003729111049324274,
-0.008063939400017262,
-0.017086492851376534,
-0.015327278524637222,
-0.02283817157149315,
0.008569581434130669,
0.01173511240631342,
0.006573348306119442,
-0.052249692380428314,
-0.03925047442317009,
0.007163264323025942,
-0.001569597632624209,
0.0299592986702919,
-0.03604807332158089,
0.022458940744400024,
0.031160200014710426,
0.054019439965486526,
-0.015843454748392105,
-0.04211578145623207,
0.03861842304468155,
0.026230188086628914,
-0.060761336237192154,
0.0034209853038191795,
0.016285892575979233,
-0.021847955882549286,
-0.0007064506062306464,
0.019583100453019142,
-0.04144158959388733,
0.01984645612537861,
-0.008806601166725159,
0.01481110230088234,
-0.0003109238459728658,
-0.02993823029100895,
0.010471006855368614,
-0.007890124805271626,
0.03337238356471062,
-0.007911193184554577,
-0.0599185973405838,
-0.07989146560430527,
0.010565814562141895,
0.019488291814923286,
0.01862448640167713,
0.015106060542166233,
-0.01578024961054325,
0.02315419912338257,
0.014063172973692417,
0.06560707092285156,
-0.004340095445513725,
-0.0005573256639763713,
0.024818602949380875,
0.0029811819549649954,
-0.001821101875975728,
0.02551386132836342,
0.01720236800611019,
-0.010344596579670906,
-0.015327278524637222,
-0.01859288476407528,
-0.029537931084632874,
0.021542463451623917,
0.04748822748661041,
-0.012156480923295021,
-0.02713613025844097,
-0.03088630922138691,
-0.014094775542616844,
-0.0022674892097711563,
0.0017262940527871251,
-0.03604807332158089,
0.004545512609183788,
0.02917976677417755,
-0.0008743396028876305,
0.011850988492369652,
-0.02555599808692932,
-0.007605701219290495,
0.033351317048072815,
-0.019351348280906677,
-0.000771631021052599,
-0.02315419912338257,
-0.004445437341928482,
0.047698911279439926,
0.008063939400017262,
-0.01593826338648796,
-0.05507286265492439,
-0.00937544833868742,
0.02191116102039814,
0.029601136222481728,
-0.01862448640167713,
0.004155746661126614,
0.011534961871802807,
-0.013178299181163311,
0.02207970805466175,
0.02854771539568901,
-0.020057139918208122,
-0.038555216044187546,
-0.012525178492069244,
-0.01669672690331936,
0.013378449715673923,
-0.04921583831310272,
0.0075846328400075436,
-0.0010481540812179446,
-0.03598487004637718,
-0.021026287227869034,
-0.0157907847315073,
0.04285317659378052,
-0.057769618928432465,
0.016507109627127647,
0.005646337755024433,
0.04270569607615471,
-0.039334747940301895,
-0.037902094423770905,
-0.032719261944293976,
-0.016422836109995842,
-0.031918663531541824,
-0.005804351065307856,
0.01506392378360033,
-0.022437872365117073,
-0.012704259715974331,
-0.05781175568699837,
0.03330918028950691,
0.05026926100254059,
-0.025808820500969887,
0.02047850750386715,
0.04930011183023453,
-0.01781335286796093,
0.08406301587820053,
0.05663192272186279,
0.025429587811231613,
0.0567161962389946,
0.0037422787863761187,
-0.01528514176607132,
0.00556206377223134,
0.02146872505545616,
-0.05372448265552521,
0.03640623763203621,
0.0022964582312852144,
-0.01606467366218567,
-0.033140629529953,
-0.04424368962645531,
0.07601487636566162,
0.010255055502057076,
0.00406620604917407,
-0.05498858541250229,
-0.02083667181432247,
-0.04786745831370354,
0.0062099178321659565,
0.016138412058353424,
0.012019536457955837,
0.048625923693180084,
0.02298565022647381,
-0.040746331214904785,
0.025598134845495224,
0.003226102562621236,
0.02665155753493309,
-0.0036027005407959223,
0.03282460570335388,
-0.0005471206386573613,
-0.007294941693544388,
-0.001847437466494739,
0.02332274615764618,
-0.03866055980324745,
0.042495012283325195,
0.03290887922048569,
-0.06961007416248322,
-0.052586786448955536,
0.04403300583362579,
0.0035026255063712597,
-0.010544746182858944,
0.019119594246149063,
-0.009322777390480042,
-0.03212934732437134,
0.05979218706488609,
-0.0362376905977726,
0.0551571361720562,
0.024228688329458237,
-0.025408519431948662,
-0.02631446160376072,
-0.0678403228521347,
-0.018540212884545326,
-0.06337381899356842,
0.004229485988616943,
-0.033330246806144714,
0.0441594161093235,
-0.000298414466669783,
0.05532568320631981,
-0.0004319027066230774,
-0.010118111036717892,
-0.01796083152294159,
0.01766587421298027,
-0.015695976093411446,
0.008327295072376728,
0.0003206350957043469,
-0.0220586396753788,
0.015695976093411446,
-0.01497964933514595,
0.015369415283203125,
0.046603355556726456,
-0.0520811453461647,
0.01718129962682724,
-0.029390452429652214,
0.010602684691548347,
-0.008653854951262474,
0.025429587811231613,
-0.0145793491974473,
-0.001465572277083993,
-0.012030070647597313,
-0.057306114584207535,
0.06497502326965332,
0.02429189346730709,
-0.0019132762681692839,
0.0000792534847278148,
0.039355818182229996,
-0.04854165017604828,
0.02174261398613453,
-0.05010071396827698,
0.0002111780340783298,
-0.044201552867889404,
0.004645587410777807,
-0.0299592986702919,
-0.021826887503266335,
-0.021394984796643257,
0.01700221747159958,
0.04622412100434303,
0.028021004050970078,
-0.014021036215126514,
0.0012094592675566673,
0.04114663228392601,
-0.02458685077726841,
0.04285317659378052,
0.011682441458106041,
-0.02412334643304348,
-0.02976968325674534,
0.018508611246943474,
-0.04222112149000168,
-0.008306226693093777,
0.03394123166799545,
0.07011571526527405,
0.025766683742403984,
0.004340095445513725,
-0.05549423024058342,
0.014768965542316437,
0.03385695815086365,
0.0260195042937994,
0.007468756288290024,
-0.019951798021793365,
-0.07462435960769653,
0.0033920162823051214,
-0.02840023674070835,
-0.01797136664390564,
-0.032403238117694855,
-0.010528945364058018,
0.04238966852426529,
-0.01639123447239399,
-0.013094025664031506,
-0.0058728232979774475,
0.04083060473203659,
-0.03748072683811188,
0.0244604405015707,
-0.005609468091279268,
-0.006736628711223602,
0.043906595557928085,
-0.009006751701235771,
-0.008300959132611752,
-0.004703525919467211,
0.024945015087723732,
-0.031139131635427475,
0.02082613669335842,
-0.011703509837388992,
0.014958580955862999,
-0.006515410263091326,
0.003492091316729784,
-0.0016933745937421918,
-0.02378625050187111,
-0.01844540610909462,
0.012704259715974331,
-0.003434153040871024,
0.01956203207373619,
0.022353598847985268,
0.027346814051270485,
-0.004553413018584251,
0.06573348492383957,
0.033519864082336426,
0.016370166093111038,
0.032382167875766754,
-0.007531961891800165,
0.020678658038377762,
-0.014400267973542213,
-0.039145130664110184,
0.04118876904249191,
-0.014621485956013203,
-0.018803568556904793,
0.004945812746882439,
-0.02256428264081478,
-0.010934512130916119,
-0.0017618469428271055,
0.005209167953580618,
0.006441670935600996,
0.03280353546142578,
0.008490574546158314,
0.008759197778999805,
0.009601933881640434,
-0.030970582738518715,
-0.028948014602065086,
-0.0007986249402165413,
-0.020920945331454277,
-0.0582752600312233,
-0.042579285800457,
-0.013778749853372574,
-0.0260195042937994,
0.01879303529858589,
-0.0086591225117445,
0.005488324444741011,
-0.03059135191142559,
0.010755430907011032,
-0.022817103192210197,
-0.02867412567138672,
0.013431120663881302,
-0.0030364866834133863,
-0.0010534211760386825,
-0.0033656808082014322,
0.0205206461250782,
0.041525863111019135,
-0.01751839555799961,
-0.010291925631463528,
-0.011987932957708836,
-0.007784782908856869,
0.030464941635727882,
0.0015827653696760535,
0.009106826037168503,
0.0013826153008267283,
0.015980400145053864,
0.03708042576909065,
-0.00575167965143919,
-0.04694044962525368,
-0.006841970607638359,
-0.029390452429652214,
0.006309993099421263,
-0.021521395072340965,
-0.01969897747039795,
-0.03404657170176506,
0.027367882430553436,
0.006062439177185297,
0.00868019089102745,
-0.01703382097184658,
-0.03139195218682289,
0.03088630922138691,
0.008569581434130669,
-0.008211418054997921,
-0.021531930193305016,
-0.032550714910030365,
0.01545368880033493,
0.015643304213881493,
-0.02568240836262703,
0.005404050927609205,
-0.019920194521546364,
-0.01417904905974865,
-0.014126378111541271,
-0.009881091304123402,
-0.02667262591421604,
0.04369591176509857,
0.004034603014588356,
0.028821604326367378,
-0.015221936628222466,
0.0008460289100185037,
0.01246197335422039,
-0.0015037588309496641,
0.004413834773004055,
-0.0020252023823559284,
-0.011745646595954895,
-0.019161731004714966,
-0.007326544728130102,
0.016633521765470505,
-0.0006761647528037429,
-0.018877308815717697,
-0.041378386318683624,
0.01872982829809189,
0.0026282859034836292,
0.02161620371043682,
-0.027030788362026215,
-0.03181331977248192,
-0.04335881769657135,
0.03895551711320877,
-0.016443904489278793,
-0.054482944309711456,
-0.020552247762680054,
0.00030927787884138525,
0.028631988912820816,
-0.0019185433629900217,
-0.008100809529423714,
0.029264042153954506,
-0.003012784756720066,
-0.0038344531785696745,
-0.005409318022429943,
0.014600417576730251,
0.04740395396947861,
-0.01764480583369732,
-0.024839671328663826,
0.0037449123337864876,
-0.016433371230959892,
0.0032076674979180098,
0.014705760404467583,
-0.05435653403401375,
-0.022774966433644295,
-0.01703382097184658,
0.01593826338648796,
0.0013477207394316792,
0.007484557572752237,
-0.013905160129070282,
-0.009596667252480984,
0.04194723442196846,
-0.009164764545857906,
-0.030844172462821007,
0.050395671278238297,
0.006367931142449379,
0.01750786043703556,
0.0153799494728446,
-0.02490287832915783,
0.02808420918881893,
-0.009438654407858849,
-0.026756899431347847,
0.009949563071131706,
-0.026251256465911865,
-0.05612628161907196,
-0.018656089901924133,
-0.0005454746424220502,
-0.041715480387210846,
-0.02679903618991375,
-0.0536402091383934,
-0.01403157040476799,
0.028779467567801476,
0.02743108756840229,
-0.00804813764989376,
0.0014905909774824977,
0.026082709431648254,
-0.00393716199323535,
0.03891338035464287,
-0.011545496061444283,
0.0157486479729414,
0.011798317544162273,
-0.0157486479729414,
-0.022732829675078392,
0.017065424472093582,
0.006157246883958578,
-0.010850238613784313,
0.03200293704867363,
0.009054155088961124,
0.03488931059837341,
-0.0007564881234429777,
0.029369384050369263,
0.0016604551346972585,
0.0028890075627714396,
0.026419803500175476,
-0.010839704424142838,
-0.00247949012555182,
-0.03701722249388695,
0.04542352259159088,
-0.0010567131685093045,
0.025935230776667595,
-0.03710149601101875,
-0.0331195630133152,
0.0027046590112149715,
-0.011134662665426731,
-0.0016499209450557828,
0.000011079439900640864,
0.006994716823101044,
0.003341978881508112,
0.00334724597632885,
-0.008559047244489193,
-0.017391983419656754,
-0.041715480387210846,
-0.050985585898160934,
0.002875839825719595,
-0.0024676392786204815,
-0.0067313616164028645,
-0.025282109156250954,
-0.023554498329758644,
0.01845593936741352,
0.0011383532546460629,
0.003199766855686903,
-0.06543852388858795,
0.026230188086628914,
-0.003497358411550522,
-0.008100809529423714,
0.004993216600269079,
0.004837837070226669,
-0.005920227151364088,
-0.01325203850865364,
0.0032419038470834494,
0.004930011462420225,
-0.010634287260472775,
0.023870524019002914,
-0.013209901750087738,
-0.001688107498921454,
0.05254464969038963,
-0.0012101175962015986,
0.02507142536342144,
0.010871306993067265,
-0.04828882962465286,
0.013820886611938477,
0.021869024261832237,
0.05418798699975014,
0.023533429950475693,
-0.03181331977248192,
0.052418239414691925,
-0.01984645612537861,
0.016454439610242844,
-0.0024123345501720905,
-0.016612453386187553,
-0.03455221652984619,
-0.003247170941904187,
-0.021784750744700432,
0.006378465332090855,
-0.0074476879090070724,
-0.05233396589756012,
-0.010781765915453434,
-0.0007926994585432112,
0.02726254053413868,
-0.039334747940301895,
-0.005177565384656191,
-0.001196291414089501,
0.004856271669268608,
0.004779898561537266,
0.012841204181313515,
0.014463473111391068,
-0.006051904987543821,
-0.05932868272066116,
0.011134662665426731,
0.004258455242961645,
-0.019993934780359268,
0.004764097277075052,
0.01008124090731144,
-0.025935230776667595,
0.00913842860609293,
-0.0036580052692443132,
0.006868306081742048,
-0.05545209348201752,
-0.012103809975087643,
0.0018290026346221566,
0.009080491028726101,
-0.0007854572031646967,
-0.0005099216941744089,
0.028653057292103767,
0.0071105933748185635,
0.02587202563881874,
-0.014094775542616844,
0.0181188452988863,
-0.034615419805049896,
-0.009928494691848755,
0.013768215663731098,
-0.028021004050970078,
0.013831420801579952,
0.02429189346730709,
-0.025471724569797516,
-0.0009928494691848755,
-0.015590634196996689,
-0.015864523127675056,
-0.005132794845849276,
-0.012725328095257282,
0.0019777982961386442,
0.01277799904346466,
-0.011882591061294079,
-0.012493575923144817,
0.015221936628222466,
0.019446155056357384,
-0.018182050436735153,
-0.012325027957558632,
-0.013989433646202087,
0.02741001918911934,
-0.00811661034822464,
0.0074792904779314995,
0.015327278524637222,
0.04274783283472061,
0.040746331214904785,
-0.05334525182843208,
-0.010966114699840546,
0.0067945667542517185,
0.00044539966620504856,
-0.02884267270565033,
-0.027178267017006874,
-0.027810320258140564,
-0.00686303898692131,
0.0010672473581507802,
-0.019583100453019142,
0.045465659350156784,
-0.04559206962585449,
0.01135588064789772,
-0.03282460570335388,
-0.03242430463433266,
-0.017887091264128685,
0.004782532341778278,
-0.0756356418132782,
0.004166280850768089,
0.013578599318861961,
0.011240004561841488,
0.010987183079123497,
0.019288143143057823,
0.036490511149168015,
-0.013346847146749496,
0.008069206029176712,
-0.013578599318861961,
0.017065424472093582,
-0.03354093059897423,
-0.01638069935142994,
-0.03579525277018547,
0.01033406239002943,
-0.011893125250935555,
0.0189299788326025,
0.0018869407940655947,
-0.05123840644955635,
-0.004442804027348757,
0.010023302398622036,
-0.015559031628072262,
-0.030928445979952812,
-0.0029179768171161413,
0.0141895841807127,
0.007984932512044907,
0.005878090392798185,
-0.03908192738890648,
-0.0488787442445755,
-0.03906085714697838,
-0.001277931616641581,
0.04386445879936218,
-0.013652338646352291,
0.015190334059298038,
-0.029601136222481728,
-0.005106459371745586,
0.012904410250484943,
0.008880340494215488,
-0.023701976984739304,
-0.008980415761470795,
0.053050290793180466,
0.007863789796829224,
0.018719295039772987,
-0.04778318479657173,
0.006136178504675627,
0.009849488735198975,
0.011345346458256245,
-0.020120345056056976,
-0.004284790717065334,
-0.009106826037168503,
0.0268201045691967,
-0.027220403775572777,
-0.0025045089423656464,
0.005688474513590336,
0.015727579593658447,
-0.030970582738518715,
0.007126394659280777,
-0.00445070443674922,
-0.01033406239002943,
-0.001286490703932941,
-0.014115843921899796,
0.010613218881189823,
0.00937018170952797,
-0.011798317544162273,
-0.004872072953730822,
0.005332944914698601,
0.006425869185477495,
0.009085757657885551,
-0.023048855364322662,
0.01433706283569336,
-0.031602635979652405,
0.007047387771308422,
-0.04222112149000168,
0.000673531205393374,
-0.02741001918911934,
0.02930617891252041,
0.018972115591168404,
0.016370166093111038,
0.0007584632840007544,
0.014758431352674961,
-0.026567282155156136,
-0.008458971977233887,
-0.011798317544162273,
0.04133624956011772,
-0.031434088945388794,
-0.02821061946451664,
-0.05616841837763786,
-0.051954735070466995,
0.006752429995685816,
-0.00834836345165968,
-0.011240004561841488,
0.006067706272006035,
-0.023238472640514374,
0.03168690949678421,
-0.023133128881454468,
0.06071919947862625,
-0.014052638784050941,
-0.00278103188611567,
-0.03029639460146427,
-0.007995466701686382,
-0.021089492365717888,
0.01521140243858099,
-0.007284407503902912,
0.039482228457927704,
-0.005182832479476929,
-0.041062358766794205,
-0.016296425834298134,
0.0015722311800345778,
-0.004403300583362579,
0.011682441458106041,
0.021953297778964043,
-0.015653839334845543,
0.021152697503566742,
-0.01751839555799961,
-0.011292675510048866,
0.006810368038713932,
-0.0043664309196174145,
-0.008627519942820072,
0.03920833766460419,
0.03210827708244324,
0.042789969593286514,
0.036343030631542206,
0.037902094423770905,
-0.006636553443968296,
-0.030928445979952812,
-0.022311462089419365,
0.008142946287989616,
0.03246644139289856,
-0.0004444120859261602,
-0.04761463776230812,
0.018055640161037445,
0.018666623160243034,
-0.01622268743813038,
0.008337829262018204,
0.0016907410463318229,
0.029453657567501068,
0.02490287832915783,
-0.013525928370654583,
0.044370099902153015,
0.021057890728116035,
-0.02001500315964222,
-0.05123840644955635,
0.044370099902153015,
-0.03383588790893555,
0.033014219254255295,
-0.007152730133384466,
-0.04061992093920708,
-0.0473196804523468,
-0.00575167965143919,
-0.023870524019002914,
-0.012440904974937439,
0.023112060502171516,
0.020689193159341812,
0.01513766311109066,
-0.05191259831190109,
0.03347772732377052,
0.002152929548174143,
-0.03389909490942955,
0.05157550424337387,
-0.013620736077427864,
0.024544714018702507,
0.013273106887936592,
0.014157980680465698,
-0.02220611833035946,
0.003981932066380978,
0.03242430463433266,
0.012293425388634205,
0.030464941635727882,
-0.02064705640077591,
-0.014463473111391068,
0.00598869938403368,
0.03798636794090271,
-0.048499513417482376,
0.017539463937282562,
0.016991684213280678,
0.011682441458106041,
0.04664549231529236,
0.001130452612414956,
-0.015348346903920174,
-0.009206901304423809,
0.016644055023789406,
-0.03611128032207489,
-0.026546213775873184,
-0.0393979549407959,
0.046434808522462845,
0.04694044962525368,
-0.016275357455015182,
-0.005835953634232283,
0.015527429059147835,
0.029264042153954506,
-0.07588846236467361,
-0.022817103192210197,
0.04129411280155182,
0.02176368236541748,
0.016633521765470505,
-0.042305395007133484,
0.03501572087407112,
0.003923994023352861,
0.0012377699604257941,
-0.01048154104501009,
-0.02818955108523369,
-0.033203836530447006,
0.015011251904070377,
0.008864539675414562,
-0.014284391887485981,
0.004785165656358004,
0.0032287361100316048,
-0.011482290923595428,
0.013715543784201145,
0.026925446465611458,
0.022774966433644295,
-0.016759932041168213,
0.003018051851540804,
-0.00740555115044117,
0.0409991517663002,
0.010471006855368614,
0.05789602920413017,
-0.009928494691848755,
-0.0133889839053154,
0.010255055502057076,
-0.03533174842596054,
0.0362798273563385,
-0.010966114699840546,
0.06071919947862625,
0.04064099118113518,
-0.014632021076977253,
-0.03436259925365448,
-0.0036738065537065268,
0.03227682411670685,
0.03202400356531143,
-0.029706478118896484,
-0.015559031628072262,
-0.05111199617385864,
0.0067313616164028645,
0.033203836530447006,
-0.005472523160278797,
0.023596635088324547,
0.03684867545962334,
0.0016986416885629296,
0.00334724597632885,
-0.022901376709342003,
0.01057108212262392,
-0.008580115623772144,
-0.003083890536800027,
-0.018045105040073395,
-0.0053434791043400764,
0.011893125250935555,
0.003202400403097272,
-0.013462723232805729,
-0.008011268451809883,
-0.0005428410950116813,
0.029896093532443047,
-0.0007064506062306464,
0.001402367022819817,
0.006146712694317102,
-0.008327295072376728,
-0.012145946733653545,
0.00634159566834569,
-0.032571785151958466,
0.0009112093248404562,
-0.006431136280298233,
0.0007242271094582975,
-0.021637272089719772,
-0.010765965096652508,
-0.015464222989976406,
-0.004953713156282902,
-0.004316393285989761,
-0.015116594731807709,
0.027978867292404175,
-0.014084241352975368,
-0.012746396474540234,
-0.002665155567228794,
-0.011366414837539196,
-0.011861522682011127,
0.019625237211585045,
-0.004671922884881496,
0.0030312195885926485,
-0.025282109156250954,
-0.04285317659378052,
0.0025426954962313175,
-0.005951829720288515,
-0.004664022475481033,
0.003734378144145012,
0.0011692974949255586,
0.05629482865333557,
-0.0011844404507428408,
0.03330918028950691,
0.02393372915685177,
0.009586133062839508,
-0.021036822348833084,
-0.020236222073435783,
0.05090131238102913,
-0.00764257088303566,
-0.04934224858880043,
0.024860739707946777,
0.039966799318790436,
0.00156696408521384,
0.0069051762111485004,
-0.021321244537830353,
-0.0032787735108286142,
0.008553780615329742,
0.050985585898160934,
-0.005098558496683836,
-0.022964581847190857,
0.016486041247844696,
-0.012419835664331913,
0.00740555115044117,
-0.06004500761628151,
0.010228719562292099,
0.0378810279071331,
0.015990933403372765,
0.01623322069644928,
-0.02018355019390583,
0.006094041746109724,
-0.01545368880033493,
-0.005504125729203224,
-0.0472775436937809,
0.005064322613179684,
0.0409780852496624,
-0.018182050436735153,
0.0003940453752875328,
0.010102309286594391,
-0.024650055915117264,
-0.02741001918911934,
0.026841172948479652,
-0.01285173837095499,
0.012261822819709778,
0.0059728980995714664,
-0.014863773249089718,
0.007084257435053587,
-0.0076899747364223,
-0.0033841156400740147,
-0.03577418252825737,
0.039166200906038284,
-0.01112412754446268,
-0.00535928038880229,
0.013136162422597408,
0.022796034812927246,
0.0034999919589608908,
0.0013128261780366302,
0.02538745105266571,
-0.012714793905615807,
-0.0110293198376894,
-0.004787799436599016,
0.020710261538624763,
0.011018785648047924,
-0.0008460289100185037,
0.0015024420572444797,
0.012198617681860924,
0.0019356614211574197,
0.01260945200920105,
0.011714044027030468,
-0.012082741595804691,
-0.017750147730112076,
0.050353534519672394,
-0.04445437341928482,
0.004685090854763985,
-0.015422086231410503,
0.009686208330094814,
0.03988252580165863,
0.007937529124319553,
0.00764257088303566,
0.053176701068878174,
-0.007884858176112175,
0.0024952914100140333,
-0.01894051395356655,
-0.003958230372518301,
0.018024036660790443,
-0.02351236157119274,
-0.03432046249508858,
-0.0018843072466552258,
0.04588702693581581,
0.018561281263828278,
0.025829888880252838,
-0.010692224837839603,
0.012662122957408428,
-0.009638804011046886,
-0.031286608427762985,
0.010665889829397202,
0.000608679954893887,
0.027346814051270485,
-0.011545496061444283,
0.011081990785896778,
-0.05060635507106781,
-0.013462723232805729,
0.024060141295194626,
0.023259541019797325,
-0.004226852674037218,
0.03219255059957504,
-0.00480360072106123,
0.017876558005809784,
-0.024860739707946777,
0.02319633588194847,
-0.012872806750237942,
0.026356598362326622,
-0.024060141295194626,
0.022332530468702316,
0.0008045504218898714,
-0.006115110125392675,
0.019951798021793365,
-0.006025569513440132,
-0.06548066437244415,
0.0009895575931295753,
0.013641804456710815,
-0.0010863406350836158,
0.02648300863802433,
-0.0012489624787122011,
0.0022622221149504185,
0.0041057090274989605,
0.01513766311109066,
0.012546246871352196,
-0.015021786093711853,
-0.020109811797738075,
0.0059728980995714664,
0.0018145180074498057,
0.001835586503148079,
0.005693741608411074,
-0.017265573143959045,
0.01490591000765562,
0.014242255128920078,
-0.01641230285167694,
-0.011039854027330875,
0.016012001782655716,
0.007294941693544388,
0.04921583831310272,
0.01813991367816925,
0.009907426312565804,
-0.008274623192846775,
-0.010028569959104061,
-0.05229182913899422,
0.013873557560145855,
-0.009723077528178692,
0.01876143179833889,
-0.007036853581666946,
0.009170032106339931,
-0.035879526287317276,
0.006736628711223602,
-0.002728360937908292,
-0.010228719562292099,
-0.035247474908828735,
0.0014813735615462065,
0.026567282155156136,
-0.018382200971245766,
-0.022627487778663635,
0.004563947208225727,
-0.00030006043380126357,
-0.01378928404301405,
0.021479258313775063,
0.0029364116489887238,
-0.02083667181432247,
-0.002802100498229265,
-0.011250538751482964,
-0.0012107760412618518,
-0.008922477252781391,
0.02141605317592621,
0.006230986677110195,
0.003671173006296158,
-0.019614702090620995,
-0.031244473531842232,
0.027199335396289825,
0.03166584298014641,
0.021489793434739113,
0.0006853821687400341,
-0.013873557560145855,
0.01443187054246664,
-0.0023833655286580324,
0.01669672690331936,
-0.002098941709846258,
0.008695991709828377,
0.005140695720911026,
-0.0036369366571307182,
0.05970791354775429,
0.02193222939968109,
-0.03172904625535011,
-0.0038081177044659853,
0.02536638267338276,
0.011724578216671944,
0.0036527379415929317,
0.014653089456260204,
-0.018708759918808937,
-0.030148915946483612,
-0.01426332350820303,
0.004743028897792101,
-0.0036738065537065268,
0.0023662473540753126,
-0.0165703147649765,
-0.023133128881454468,
0.01719183474779129,
-0.0048325699754059315,
-0.016633521765470505,
-0.05233396589756012,
0.006889374926686287,
-0.008079741150140762,
-0.027936730533838272,
0.023996934294700623,
-0.03200293704867363,
0.013546996749937534,
0.01315723080188036,
0.015875058248639107,
0.028884809464216232,
0.03453114628791809,
0.03134981542825699,
-0.002673056209459901,
0.03872376307845116,
-0.00674189580604434,
0.004521810449659824,
-0.036490511149168015,
-0.0030970582738518715,
-0.03606914356350899,
-0.045929163694381714,
0.005198633763939142,
-0.017297176644206047,
0.0035368616227060556,
0.004195250105112791,
0.007732111494988203,
0.030654557049274445,
0.00962300319224596,
-0.008253554813563824,
-0.007884858176112175,
-0.006599683780223131,
-0.01506392378360033,
0.018487542867660522,
-0.005962363909929991,
0.008063939400017262,
0.01481110230088234,
0.019477758556604385,
-0.005056421738117933,
0.02648300863802433,
0.018972115591168404,
0.022817103192210197,
-0.007837453857064247,
0.0165597815066576,
-0.020604919642210007,
0.009212168864905834,
-0.0006205309182405472,
0.0011179432040080428,
0.0043348283506929874,
-0.0536402091383934,
0.020752398297190666,
0.01049734279513359,
0.020857740193605423,
-0.011166265234351158,
0.029285110533237457,
0.006647087633609772,
-0.027620704844594002,
0.008933011442422867,
-0.00421368470415473,
0.015443154610693455,
0.002159513533115387,
-0.027662841603159904,
-0.0036790736485272646,
-0.02821061946451664,
0.011176799423992634,
0.016170015558600426,
-0.01505338866263628,
0.014948046766221523,
0.027515362948179245,
-0.008553780615329742,
-0.007784782908856869,
0.000308619491988793,
0.014526678249239922,
-0.013978899456560612,
-0.02743108756840229,
0.006747162900865078,
-0.023238472640514374,
-0.019583100453019142,
-0.019751647487282753,
-0.002367564244195819,
0.00013011398550588638,
-0.005103825591504574,
-0.03722790628671646,
0.023385951295495033,
-0.009817885234951973,
-0.027873525395989418,
-0.025029288604855537,
-0.009354379959404469,
0.019646305590867996,
0.021384449675679207,
-0.018213652074337006,
-0.00299434969201684,
-0.003086524084210396,
-0.0010823903139680624,
0.017054889351129532,
0.013515394181013107,
0.030675625428557396,
0.005472523160278797,
-0.02081560343503952,
0.019656840711832047,
0.006847237702459097,
0.011598167940974236,
-0.00662601925432682,
-0.04508642852306366,
-0.016517644748091698,
-0.0315183624625206,
0.012725328095257282,
0.014926978386938572,
0.016781000420451164,
0.0018461206927895546,
0.021405519917607307,
-0.0488366074860096,
-0.004400667268782854,
0.010186582803726196,
0.010550013743340969,
0.02349129319190979,
0.04131517931818962,
-0.004698258824646473,
-0.024376166984438896,
-0.031939730048179626,
0.019045855849981308,
-0.008432636968791485,
-0.01638069935142994,
0.038681626319885254,
-0.0035394951701164246,
-0.0598764605820179,
0.025008220225572586,
-0.012051139026880264,
0.0032445373944938183,
-0.017929229885339737,
-0.022311462089419365,
-0.037417519837617874,
0.009206901304423809,
-0.06059278920292854,
0.00657861540094018,
0.026061641052365303,
0.029221903532743454,
-0.0011989249614998698,
0.0012897825799882412,
-0.011398017406463623,
0.022185049951076508,
-0.0205206461250782,
-0.025155698880553246,
-0.044201552867889404,
-0.019435621798038483,
-0.02298565022647381,
0.01797136664390564,
0.04032496362924576,
0.03689081221818924,
0.045634206384420395,
0.03653264790773392,
0.00930170901119709,
-0.016306960955262184,
-0.030654557049274445,
-0.012577849440276623,
-0.014684692025184631,
-0.013536462560296059,
0.017697475850582123,
-0.004795699845999479,
0.0078743239864707,
-0.01553796324878931,
0.020404769107699394,
0.0378178209066391,
-0.001673622988164425,
-0.008595917373895645,
-0.007869056425988674,
0.024523645639419556,
-0.014305460266768932,
-0.013968365266919136,
0.06741895526647568,
-0.027009719982743263,
-0.009433386847376823,
0.010033836588263512,
-0.02509249374270439,
0.01906692422926426,
-0.007768981624394655,
-0.014674157835543156,
0.02443937212228775,
-0.015811853110790253,
0.042473942041397095,
0.008638054132461548,
0.022774966433644295,
0.05123840644955635,
0.015811853110790253,
-0.019804319366812706,
0.0007090841536410153,
0.027978867292404175,
0.0037133097648620605,
-0.045339249074459076,
0.004732494708150625,
0.015727579593658447,
0.0066628893837332726,
0.025914162397384644,
0.00993376225233078,
0.021679408848285675,
-0.004369064699858427,
-0.002638820093125105,
0.005111726466566324,
0.0060466378927230835,
0.014326528646051884,
0.012114344164729118,
0.059497229754924774,
-0.005878090392798185,
0.021953297778964043,
-0.021226437762379646,
-0.012219686061143875,
0.012946547009050846,
-0.026356598362326622,
0.031244473531842232,
0.0015590634429827332,
-0.01827685721218586,
-0.026082709431648254,
-0.0035605637822300196,
-0.014400267973542213,
0.002433402929455042,
-0.03202400356531143,
-0.010102309286594391,
0.005509392824023962,
-0.011292675510048866,
0.02646194025874138,
0.033793751150369644,
0.028315961360931396,
0.022585351020097733,
-0.05507286265492439,
-0.012240754440426826,
0.02097361721098423,
-0.028337029740214348,
0.014990183524787426,
-0.006831436417996883,
0.0009368864702992141,
0.02146872505545616,
-0.004858905449509621,
-0.014221186749637127,
-0.016928479075431824
] | 2024-12-26 | 123 | 39722028 | [
"HER2 positive breast cancer",
"breast cancer",
"immune checkpoint inhibitors",
"T cell receptor engineered cells",
"recent major clinical trials",
"ongoing clinical trials",
"tumor infiltrating lymphocytes",
"hormone receptor",
"Antibody drug conjugates",
"FDA approval",
"bispecific antibodies",
"FDA",
"Substantial therapeutic advancement",
"cellular therapies",
"triple negative and HER2+ disease",
"chimeric antigen receptor-T cells",
"The immune checkpoint inhibitor pembrolizumab",
"immunotherapy",
"early-stage triple-negative breast cancer",
"active research",
"HER2",
"combination",
"future directions",
"areas",
"chemotherapy",
"the current treatment landscape",
"Vaccines",
"Studies",
"both PD-L1 positive metastatic",
"the treatment"
] | [
"Antibody drug conjugate",
"Bispecific antibody",
"Breast cancer",
"Cellular therapy",
"Immune checkpoint inhibitor",
"Immunotherapy"
] | 0 | 10.1186/s13045-024-01649-z | [
"Heater",
"Warrior",
"Lu"
] | [
"Department of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL, 60611, USA.",
"Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 676 N St. Clair, Suite 850, Chicago, IL, 60611, USA.",
"Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 676 N St. Clair, Suite 850, Chicago, IL, 60611, USA. [email protected]."
] | [
"39722028",
"35685630",
"32266087",
"29567705",
"37939105",
"37970594",
"27166974",
"31079793",
"22068656",
"35303904",
"30345906",
"35053471",
"33223991",
"35857659",
"19917869",
"31901781",
"32461104",
"37129893",
"35680043",
"29428479",
"31095287",
"35017545",
"32246128",
"37304306",
"34724392",
"32850400",
"37111629",
"24777111",
"36866462",
"36608303",
"27138582",
"30475950",
"30475947",
"33676601",
"33278935",
"30242306",
"30347025",
"34219000",
"33214229",
"38755096",
"35728379",
"29721177",
"34716198",
"32771088",
"31194225",
"38236575",
"33462450",
"33882206",
"38422473",
"38652877",
"24529560",
"32046998",
"34902335",
"32278621",
"32053137",
"32101663",
"38369015",
"35139274",
"37991778",
"36585404",
"32966830",
"35182721",
"35961599",
"34143979",
"34638323",
"38092228",
"21572124",
"32718986",
"36268941",
"26291768",
"29027598",
"36759673",
"29559561",
"32880602",
"36027558",
"37633306",
"36335120",
"37709297",
"37741273",
"38513188",
"34667023",
"32164163",
"30765258",
"36252998",
"34154926",
"33002436",
"35320644",
"36495879",
"38825627",
"38796287",
"38547891",
"37870536",
"37488289",
"32058843",
"35665782",
"35763704",
"24907636",
"31036542",
"32323103",
"38111570",
"28249141",
"36400106",
"34844975",
"27387446",
"30282693",
"34117114",
"0",
"37426654",
"29385370",
"33979178",
"35104158",
"29109077",
"37377890",
"37904019",
"36813894",
"27860544",
"20179677",
"31501612",
"38554725",
"39038917",
"28809608",
"0",
"35749374"
] | [] | 10.752193 | 4.30269 |
39717765 | 96 | Case report: A novel third-generation anti-CD19/CD22 CAR T-cells combined with auto-HSCT for relapsed Burkitt lymphoma. | This study explores a novel therapeutic strategy for relapsed/refractory (R/R) Burkitt lymphoma (BL) by integrating autologous hematopoietic stem cell transplantation (ASCT) with tandem anti-CD19/CD22 chimeric antigen receptor (CAR) T cell therapy. A 20-year-old Asian male with refractory BL, whose lymphoma had not responded to multiple chemoimmunotherapy regimens, received myeloablative ASCT followed three days later by infusion of a novel third-generation CAR T cells engineered with CD28 and CD3ζ signaling domains, along with a TLR2 costimulatory domain. This resulted in sustained complete remission at the 306-day follow-up, without experiencing any severe complications. This case suggests that combining myeloablative ASCT with tandem anti-CD19/CD22 CAR T cell therapy could be an effective approach for R/R BL, warranting further clinical validation. | [
0.003224636660888791,
0.022101305425167084,
0.025943946093320847,
0.040090739727020264,
-0.02973763644695282,
-0.03867116570472717,
0.0030548383947461843,
0.043027788400650024,
-0.006027072202414274,
-0.014085604809224606,
-0.0016337343258783221,
0.0005736426683142781,
-0.06520251929759979,
0.02376563288271427,
0.030814554542303085,
-0.04226905107498169,
0.0389893464744091,
-0.01702265441417694,
0.004561606328934431,
0.057713042944669724,
0.0014004529220983386,
0.008260454051196575,
0.011986836791038513,
-0.0012528356164693832,
-0.03438796475529671,
-0.0199719425290823,
0.005871041677892208,
-0.012751693837344646,
-0.01447721105068922,
-0.049685101956129074,
-0.011497328989207745,
-0.02836701273918152,
-0.01625167950987816,
-0.005344819743186235,
-0.01683908887207508,
0.042709607630968094,
0.051055725663900375,
-0.028122257441282272,
-0.0018509536748751998,
-0.02915022522211075,
0.036272574216127396,
-0.03010476753115654,
0.042195625603199005,
0.1119995266199112,
-0.045548759400844574,
0.0038059279322624207,
0.002364937448874116,
-0.05154523625969887,
0.015639793127775192,
-0.012604841962456703,
-0.019335582852363586,
0.01918873004615307,
-0.01969047635793686,
0.06388084590435028,
-0.04535295441746712,
0.04075157642364502,
0.002481195842847228,
-0.012629317119717598,
0.005972002632915974,
0.006596125662326813,
0.015211474150419235,
0.013094349764287472,
0.0019029639661312103,
-0.010756947100162506,
-0.08796466141939163,
-0.028660716488957405,
-0.05051726847887039,
-0.012305017560720444,
0.0106712831184268,
0.0056262873113155365,
-0.021881025284528732,
-0.0003795602242462337,
0.01917649246752262,
0.028122257441282272,
0.03176909685134888,
0.024854790419340134,
0.0005770845455117524,
0.021232428029179573,
-0.002589805517345667,
-0.010261320509016514,
0.00844402052462101,
0.007220249157398939,
0.03331104665994644,
-0.04684595391154289,
-0.001108277589082718,
0.0044147539883852005,
0.011442258954048157,
-0.027094289660453796,
-0.01041429117321968,
-0.018552368506789207,
-0.009808524511754513,
-0.007544548250734806,
-0.05942632257938385,
0.02060830406844616,
-0.012702743522822857,
-0.019763901829719543,
-0.021513894200325012,
-0.0394788533449173,
0.04672357812523842,
0.023386264219880104,
0.02890547178685665,
0.018026147037744522,
0.02029012329876423,
-0.032601259648799896,
0.02345968969166279,
0.017732441425323486,
-0.028783094137907028,
-0.01103841420263052,
0.02555233985185623,
-0.014562875032424927,
0.05159418657422066,
-0.0021018267143517733,
0.006798048038035631,
0.0353425070643425,
-0.011638062074780464,
-0.05810464918613434,
-0.012268304824829102,
-0.036370474845170975,
0.006810285616666079,
0.026408977806568146,
0.0017086903098970652,
0.027877504006028175,
0.019152017310261726,
-0.03242993354797363,
-0.020302360877394676,
-0.02890547178685665,
0.08468495309352875,
-0.0339474081993103,
-0.027975406497716904,
-0.08977584540843964,
0.06936334073543549,
-0.008615347556769848,
-0.003775333520025015,
-0.037104737013578415,
-0.057566188275814056,
-0.012243828736245632,
-0.030031340196728706,
0.009961496107280254,
-0.01987404190003872,
-0.041241083294153214,
0.012231591157615185,
-0.013693997636437416,
-0.022737665101885796,
-0.021073337644338608,
-0.05115363001823425,
-0.03287049010396004,
0.004965451080352068,
0.02826911024749279,
0.0067001464776694775,
0.024928215891122818,
-0.05560815706849098,
0.03730054199695587,
0.0656430795788765,
0.01703489199280739,
-0.005240799393504858,
-0.054678089916706085,
-0.009839119389653206,
0.037838999181985855,
-0.027192192152142525,
-0.0422201007604599,
0.008774437941610813,
-0.009624958969652653,
-0.021905500441789627,
-0.022505149245262146,
0.02621317468583584,
-0.008486852049827576,
0.008664298802614212,
0.05066411942243576,
-0.07259409874677658,
0.02446318231523037,
-0.008517445996403694,
-0.0367131307721138,
-0.062167566269636154,
-0.038891442120075226,
-0.0665731430053711,
0.0016857446171343327,
0.021550606936216354,
-0.000772505474742502,
-0.012947497889399529,
-0.04050682112574577,
0.017842581495642662,
0.006235113367438316,
0.042562756687402725,
-0.0031450914684683084,
-0.032332029193639755,
0.03355580195784569,
-0.0026739398017525673,
-0.010836492292582989,
-0.016875801607966423,
-0.0003847230109386146,
0.018295377492904663,
0.028562815859913826,
0.022908993065357208,
0.0073059131391346455,
-0.02441423200070858,
0.00288045103661716,
0.036786556243896484,
0.025258634239435196,
-0.03042294830083847,
-0.029443930834531784,
0.007348745130002499,
-0.043443869799375534,
-0.054824940860271454,
-0.020498163998126984,
-0.012476345524191856,
0.032380979508161545,
0.0018065919866785407,
0.03179357200860977,
0.0072324867360293865,
-0.023410739377141,
0.04136345908045769,
-0.00777706503868103,
-0.008737725205719471,
0.035954393446445465,
-0.027559323236346245,
-0.03052084892988205,
-0.007434409111738205,
0.028709668666124344,
0.03465719521045685,
-0.0312061607837677,
0.014440498314797878,
0.0019259096588939428,
-0.021097812801599503,
0.012182640843093395,
0.0013254969380795956,
0.014673014171421528,
0.04295436292886734,
-0.024891503155231476,
0.010004328563809395,
-0.019984180107712746,
0.020363550633192062,
0.010499955154955387,
0.0015343029517680407,
-0.023141510784626007,
0.012702743522822857,
-0.011124078184366226,
-0.017842581495642662,
0.02951735630631447,
0.06451720744371414,
-0.026237651705741882,
0.00733038829639554,
0.03242993354797363,
0.05428648367524147,
-0.006418678909540176,
-0.007428290322422981,
-0.022052353248000145,
0.0106712831184268,
-0.048069726675748825,
0.009147688746452332,
-0.005904695019125938,
-0.04001731425523758,
0.034167688339948654,
-0.055314451456069946,
-0.02501387894153595,
0.00036082122824154794,
0.005822090432047844,
0.04168163985013962,
-0.0550696961581707,
-0.012170403264462948,
-0.02423066645860672,
-0.019678238779306412,
0.0006780456169508398,
-0.03020266816020012,
-0.03607676923274994,
-0.04483896866440773,
0.027779601514339447,
0.012457989156246185,
0.03475509583950043,
0.02170969732105732,
0.005999537650495768,
-0.02680058591067791,
0.008223741315305233,
0.04337044432759285,
-0.012763931415975094,
-0.01216428354382515,
-0.015309375710785389,
0.02868519350886345,
0.003285825252532959,
-0.014048891142010689,
0.02863624133169651,
0.008315524086356163,
0.004735993687063456,
-0.004439229611307383,
-0.023875772953033447,
-0.031818047165870667,
-0.00010115232726093382,
0.010781423188745975,
-0.009263946674764156,
-0.009998208843171597,
-0.02601737156510353,
-0.009300659410655499,
0.008162552490830421,
-0.01932334527373314,
-0.04415365681052208,
-0.018895024433732033,
-0.0075629050843417645,
0.002631107810884714,
-0.005344819743186235,
-0.011864460073411465,
0.04584246128797531,
-0.022872280329465866,
0.04094737768173218,
-0.004729874897748232,
-0.006914306432008743,
0.004497358575463295,
0.03862221539020538,
-0.03093693219125271,
-0.015798883512616158,
0.02501387894153595,
0.0601116344332695,
0.0058832792565226555,
-0.005041936412453651,
0.008064650930464268,
0.01601916365325451,
0.004436169750988483,
0.003392905229702592,
-0.0022196148056536913,
-0.05365012213587761,
-0.007764826994389296,
-0.06671999394893646,
-0.04378652572631836,
-0.024475419893860817,
-0.01016953680664301,
0.00032621147693134844,
0.009949258528649807,
-0.03142644092440605,
0.010536668822169304,
-0.042660657316446304,
0.012971973046660423,
-0.03529355674982071,
0.017695728689432144,
-0.04432498663663864,
0.07406262308359146,
-0.013938752003014088,
0.019788376986980438,
-0.0033011222258210182,
-0.0034418560098856688,
-0.06373399496078491,
0.04594036564230919,
0.014256932772696018,
-0.020033132284879684,
0.02349640429019928,
-0.047702595591545105,
0.019262155517935753,
0.01023072563111782,
-0.006412560120224953,
-0.01830761507153511,
0.011423902586102486,
0.012935259379446507,
0.018295377492904663,
0.0022012582048773766,
-0.006712384056299925,
0.04165716469287872,
-0.022921230643987656,
0.011784914880990982,
0.01568874530494213,
-0.02009432017803192,
-0.02161179669201374,
-0.00478494493290782,
0.0106712831184268,
0.029957914724946022,
0.05433543398976326,
-0.04767812043428421,
0.026041846722364426,
0.03282153978943825,
0.056440319865942,
-0.027412470430135727,
0.013437005691230297,
-0.02670268341898918,
-0.05418857932090759,
-0.01772020384669304,
-0.006767453625798225,
0.007599618285894394,
0.009037548676133156,
-0.00954541377723217,
0.021146763116121292,
0.045499805361032486,
0.0038579381071031094,
0.01565203070640564,
0.023802345618605614,
0.059866879135370255,
-0.023790108039975166,
-0.026286602020263672,
-0.050957825034856796,
-0.04253828153014183,
0.03786347433924675,
0.008762200362980366,
-0.015443990007042885,
-0.059817928820848465,
0.012996448203921318,
-0.03475509583950043,
-0.014305883087217808,
0.024989403784275055,
-0.008884578011929989,
0.007538429461419582,
0.0596710741519928,
0.006632838863879442,
0.08654508739709854,
0.04300331324338913,
0.02152613177895546,
-0.037055786699056625,
-0.016998179256916046,
-0.0023894128389656544,
-0.04992985725402832,
0.031328536570072174,
0.025356534868478775,
0.004485120996832848,
0.0028116139583289623,
0.026947438716888428,
-0.021183475852012634,
-0.02267647720873356,
-0.00029083681874908507,
0.0413145087659359,
-0.00690818764269352,
0.05071306973695755,
0.0021385399159044027,
-0.028293585404753685,
0.062167566269636154,
-0.018429990857839584,
0.0486571341753006,
0.05345431715250015,
-0.015138047747313976,
0.02910127490758896,
-0.03644390031695366,
0.012555890716612339,
-0.024389756843447685,
0.048583708703517914,
0.01977613940834999,
0.003282765857875347,
-0.019115302711725235,
-0.011742083355784416,
0.022554099559783936,
-0.016349580138921738,
-0.03426558896899223,
0.0035825895611196756,
0.08962898701429367,
-0.026286602020263672,
0.019103065133094788,
-0.03507327660918236,
0.00785049144178629,
-0.004319911822676659,
0.01379189919680357,
-0.014697490260004997,
-0.04363967478275299,
0.011601349338889122,
0.0019182610558345914,
0.007354863919317722,
0.04606274142861366,
-0.06153120845556259,
0.02506283111870289,
0.00736710149794817,
-0.021770887076854706,
0.006638957653194666,
0.0158355962485075,
-0.03864669054746628,
-0.014440498314797878,
0.008921290747821331,
-0.06162910908460617,
0.006663433276116848,
0.028513865545392036,
0.06001373007893562,
-0.025870518758893013,
0.0050664120353758335,
-0.05081097409129143,
0.006088261026889086,
0.03176909685134888,
0.04239142686128616,
-0.004781885072588921,
0.019984180107712746,
-0.024487657472491264,
0.03960122913122177,
-0.013192251324653625,
-0.02680058591067791,
0.02616422437131405,
-0.012225472368299961,
0.06662209331989288,
0.012084739282727242,
0.015713220462203026,
0.010640689171850681,
0.020816344767808914,
0.005142897833138704,
-0.007465003058314323,
-0.008150314912199974,
-0.03607676923274994,
0.04026206582784653,
0.00803405698388815,
0.000321431114571169,
0.010224606841802597,
-0.02831806242465973,
0.042880937457084656,
-0.015480703674256802,
0.0030043579172343016,
0.012910784222185612,
-0.011638062074780464,
-0.031230635941028595,
-0.040457870811223984,
0.015027908608317375,
0.0029905904084444046,
-0.00011405928671592847,
0.00048033014172688127,
-0.0005889398162253201,
0.05071306973695755,
0.04454526677727699,
0.0036070651840418577,
0.03287049010396004,
0.04173059016466141,
-0.018246425315737724,
0.04185296967625618,
-0.013620571233332157,
0.0048094200901687145,
-0.015517416410148144,
0.003227696055546403,
0.03507327660918236,
-0.013804136775434017,
-0.0339718833565712,
-0.029125750064849854,
-0.05590185895562172,
-0.01592126116156578,
0.014269170351326466,
-0.03781452402472496,
-0.03539145737886429,
0.01202355045825243,
-0.029982389882206917,
-0.014305883087217808,
0.029566308483481407,
-0.005246918182820082,
-0.032576784491539,
-0.02152613177895546,
-0.03881801664829254,
-0.016924753785133362,
0.014783154241740704,
-0.01106289029121399,
0.00827881135046482,
0.015223711729049683,
0.00020899713854305446,
-0.02468346245586872,
-0.025087306275963783,
0.018148524686694145,
-0.0353425070643425,
-0.02019222266972065,
0.012898546643555164,
0.008658180013298988,
0.026825061067938805,
0.0023389323614537716,
0.002380234654992819,
-0.00125971925444901,
0.03468167036771774,
-0.023875772953033447,
0.0051398384384810925,
0.010983345098793507,
0.026825061067938805,
-0.036272574216127396,
0.005727248266339302,
0.0017377549083903432,
0.025160731747746468,
-0.043199118226766586,
-0.019445721060037613,
-0.016410769894719124,
-0.010885443538427353,
-0.01298421062529087,
-0.023508641868829727,
-0.006547174882143736,
-0.012317255139350891,
-0.02968868426978588,
-0.006146389991044998,
0.016728950664401054,
-0.001408866373822093,
-0.014575112611055374,
-0.04173059016466141,
0.02963973395526409,
-0.013363579288125038,
0.0017515223007649183,
-0.012555890716612339,
-0.021648509427905083,
0.03952780365943909,
0.008450139313936234,
-0.02032683603465557,
0.005087828263640404,
0.016166014596819878,
-0.005057233851402998,
-0.023153748363256454,
-0.03583201393485069,
-0.03162224218249321,
0.07308360934257507,
-0.02184431254863739,
0.007244724314659834,
-0.02863624133169651,
-0.02046145126223564,
-0.020228935405611992,
0.026408977806568146,
0.02528310939669609,
0.020082082599401474,
0.05272005498409271,
0.008517445996403694,
-0.025356534868478775,
0.019788376986980438,
0.004540190566331148,
-0.01143002137541771,
-0.020853057503700256,
-0.004925678484141827,
0.003125205170363188,
-0.01753663830459118,
-0.0017515223007649183,
-0.013889800757169724,
-0.020596066489815712,
0.039307523518800735,
0.004769647493958473,
-0.030594276264309883,
0.02029012329876423,
0.013400292955338955,
0.07063606381416321,
0.028929946944117546,
0.0029477584175765514,
-0.023337313905358315,
0.04089842736721039,
0.015639793127775192,
-0.025026118382811546,
-0.018503418192267418,
0.02763275057077408,
-0.017818106338381767,
-0.014171268790960312,
-0.01466077659279108,
0.0188093613833189,
0.009104856289923191,
0.01248246431350708,
-0.03042294830083847,
-0.02565024048089981,
0.01355938334017992,
0.010738590732216835,
0.019812852144241333,
-0.0097534554079175,
-0.02836701273918152,
-0.0058373878709971905,
0.0298355370759964,
-0.01702265441417694,
-0.04469211772084236,
0.06099274754524231,
0.00709175318479538,
-0.020485926419496536,
0.006559412926435471,
-0.007636331021785736,
0.0028819807339459658,
-0.0004348211514297873,
-0.022199206054210663,
0.02359430491924286,
-0.01721845753490925,
-0.02910127490758896,
-0.011001701466739178,
0.011050652712583542,
-0.01840551570057869,
-0.026360027492046356,
-0.02234605886042118,
0.03409425914287567,
-0.0008229860104620457,
0.008890696801245213,
-0.009166045114398003,
0.010475479997694492,
0.005344819743186235,
0.048020776361227036,
0.048069726675748825,
-0.0019029639661312103,
0.017548875883221626,
-0.03497537598013878,
-0.004096573684364557,
-0.020987672731280327,
0.013131063431501389,
-0.02147718146443367,
-0.014048891142010689,
0.015639793127775192,
0.0025026118382811546,
0.10191565006971359,
-0.00420977221801877,
0.00917828269302845,
-0.015982449054718018,
-0.012996448203921318,
-0.001636793720535934,
0.002773371059447527,
0.0028728025499731302,
-0.009784049354493618,
0.004509596154093742,
0.0006638958002440631,
-0.018295377492904663,
-0.009600483812391758,
-0.04437393695116043,
0.002075821626931429,
-0.0012788407038897276,
0.0068837120197713375,
-0.029541833326220512,
-0.0004722991434391588,
-0.011069009080529213,
-0.008395069278776646,
-0.03477957099676132,
-0.0035030446015298367,
-0.011576874181628227,
0.023190461099147797,
0.009765692986547947,
0.0036131839733570814,
-0.037104737013578415,
-0.030325045809149742,
-0.019066352397203445,
0.03326209634542465,
0.005445781163871288,
0.047702595591545105,
-0.021954452618956566,
-0.005430483724921942,
-0.019262155517935753,
0.002729009371250868,
-0.017328597605228424,
0.019213205203413963,
0.025136256590485573,
0.001180939027108252,
0.009123212657868862,
-0.027020864188671112,
0.002260916866362095,
-0.015590842813253403,
0.025209683924913406,
0.007832134142518044,
0.07362206280231476,
-0.006406441330909729,
0.037471868097782135,
-0.017952721565961838,
0.022015640512108803,
-0.013669522479176521,
-0.020363550633192062,
0.051789991557598114,
0.05776199325919151,
-0.028097782284021378,
0.040090739727020264,
-0.013204488903284073,
-0.014122317545115948,
0.00782601535320282,
-0.017083844169974327,
-0.011050652712583542,
-0.011742083355784416,
-0.020179985091090202,
0.026678208261728287,
-0.014489448629319668,
-0.014832104556262493,
-0.006761334836483002,
0.009080381132662296,
0.03482852503657341,
-0.058447305113077164,
-0.03504880145192146,
0.02262752689421177,
-0.014978957362473011,
-0.00005076737579656765,
0.020987672731280327,
-0.002216555178165436,
-0.013706235215067863,
0.0018800182733684778,
0.015676507726311684,
0.009478106163442135,
-0.007593499030917883,
-0.013877563178539276,
-0.022786617279052734,
-0.019482433795928955,
0.009802405722439289,
0.01872369647026062,
-0.040090739727020264,
-0.03125511109828949,
-0.013400292955338955,
0.011075127869844437,
0.003965018317103386,
-0.019421245902776718,
-0.026629257947206497,
0.010475479997694492,
0.00411798944696784,
0.01510133408010006,
0.011013939045369625,
-0.005996478255838156,
0.006394203752279282,
-0.010940512642264366,
0.03681103140115738,
-0.018748171627521515,
-0.008890696801245213,
0.022358296439051628,
-0.013877563178539276,
0.020253410562872887,
-0.011674775741994381,
0.01329015288501978,
0.019054114818572998,
-0.001120515400543809,
-0.03402083367109299,
-0.0015037086559459567,
-0.026629257947206497,
-0.015713220462203026,
-0.011509566567838192,
0.03546488285064697,
-0.0321362279355526,
-0.017328597605228424,
-0.022052353248000145,
0.013963227160274982,
-0.009300659410655499,
-0.007501716259866953,
-0.0153705645352602,
0.03323762118816376,
0.030912457033991814,
-0.07998567074537277,
-0.0046258545480668545,
-0.035685162991285324,
-0.022639764472842216,
-0.01936005800962448,
0.02638450264930725,
-0.05213264748454094,
-0.004833895713090897,
0.0008528154576197267,
0.010053278878331184,
0.016484195366501808,
-0.030667701736092567,
-0.0026555832009762526,
-0.02377787046134472,
0.0005510793998837471,
0.006840880028903484,
-0.009367967024445534,
-0.006773572415113449,
-0.011289287358522415,
0.015615317970514297,
0.0019060233607888222,
0.021587321534752846,
-0.018662508577108383,
0.038255080580711365,
-0.014783154241740704,
0.01660657301545143,
0.0017652896931394935,
-0.011411665007472038,
-0.02542996220290661,
0.006951019633561373,
0.041510313749313354,
0.035734113305807114,
-0.012923021800816059,
0.009643315337598324,
-0.0002856740611605346,
-0.055363401770591736,
0.012763931415975094,
-0.01642300747334957,
0.012274423614144325,
0.03088798001408577,
-0.002800905844196677,
0.003983374685049057,
0.027926454320549965,
0.024756887927651405,
-0.009784049354493618,
0.027020864188671112,
-0.0344369150698185,
0.012470226734876633,
0.022272633388638496,
0.0053692953661084175,
0.013118825852870941,
-0.05188789218664169,
-0.02019222266972065,
0.027339044958353043,
-0.01447721105068922,
-0.010995582677423954,
-0.024561084806919098,
0.016117064282298088,
0.019298868253827095,
-0.005730307660996914,
-0.012292779982089996,
0.04341939464211464,
0.023337313905358315,
-0.0013224375434219837,
0.003484688000753522,
-0.009172163903713226,
-0.045450855046510696,
0.027706176042556763,
-0.028024356812238693,
0.004711518529802561,
-0.023667732253670692,
-0.017818106338381767,
-0.029957914724946022,
0.026237651705741882,
-0.00021760178788099438,
0.0183565653860569,
-0.013277915306389332,
0.018429990857839584,
-0.007152941543608904,
-0.026971913874149323,
-0.0007985106203705072,
-0.011270930990576744,
-0.030325045809149742,
-0.008058532141149044,
-0.035856492817401886,
-0.020179985091090202,
0.015113572590053082,
0.0119317676872015,
-0.005366235971450806,
0.017414262518286705,
-0.0009346551378257573,
-0.00511536281555891,
0.001604669727385044,
0.0004409399989526719,
0.009576008655130863,
-0.00009718463115859777,
-0.053209565579891205,
-0.017083844169974327,
0.018381040543317795,
-0.01932334527373314,
0.011179148219525814,
-0.031915947794914246,
-0.003426558803766966,
-0.013045399449765682,
-0.0021232427097857,
-0.05218159779906273,
0.041877444833517075,
0.01587231084704399,
-0.003071665298193693,
-0.06099274754524231,
0.017879294231534004,
-0.011179148219525814,
0.034950900822877884,
-0.018246425315737724,
0.017683491110801697,
0.03876906633377075,
0.0431501679122448,
-0.014783154241740704,
0.014966719783842564,
-0.004693161696195602,
0.04887741431593895,
0.035734113305807114,
0.01610482670366764,
-0.03318867087364197,
-0.010848729871213436,
0.017450975254178047,
-0.002924812724813819,
-0.019347820430994034,
-0.003059427486732602,
0.0033531326334923506,
0.03345790132880211,
0.019066352397203445,
0.0010432647541165352,
-0.01436707191169262,
-0.00687147444114089,
0.044031281024217606,
0.00472681550309062,
0.04777602106332779,
-0.014391547068953514,
0.02853834070265293,
-0.023900248110294342,
-0.01721845753490925,
-0.0009637196781113744,
0.0006784280412830412,
0.03979703411459923,
-0.0045983195304870605,
-0.03130406141281128,
0.01220711600035429,
-0.0014960600528866053,
0.05350326746702194,
0.002283862791955471,
0.041975345462560654,
0.014269170351326466,
0.045548759400844574,
-0.0004753585672006011,
0.04745784029364586,
0.01767125353217125,
-0.03130406141281128,
-0.020889772102236748,
0.02284780517220497,
-0.008138077333569527,
0.05438438430428505,
-0.009716741740703583,
-0.04099632799625397,
0.007819896563887596,
-0.012739456258714199,
0.004069038666784763,
-0.0004745936894323677,
0.009631077758967876,
0.004362743813544512,
0.010010447353124619,
-0.05590185895562172,
0.015382802113890648,
-0.004200594034045935,
-0.03977255895733833,
-0.024389756843447685,
-0.0017209280049428344,
0.01287407148629427,
0.04011521488428116,
0.01620272919535637,
-0.017108319327235222,
0.0038579381071031094,
-0.005271393805742264,
-0.003242993261665106,
0.017426500096917152,
0.0017056309152394533,
-0.03722711279988289,
-0.005222443025559187,
0.009478106163442135,
0.005721129477024078,
-0.013375816866755486,
-0.02336178906261921,
0.023741157725453377,
0.028391487896442413,
0.037692148238420486,
-0.026090798899531364,
-0.014697490260004997,
0.03419216349720955,
-0.049317970871925354,
-0.030545324087142944,
-0.04694385826587677,
0.02596842125058174,
0.031671192497015,
-0.033017341047525406,
-0.014440498314797878,
0.014819866977632046,
0.0063697281293570995,
-0.03284601494669914,
-0.04275855794548988,
0.03326209634542465,
-0.001166406786069274,
0.0357830636203289,
-0.01280064508318901,
0.001258189557120204,
0.03473062068223953,
-0.000036091685615247115,
0.009557651355862617,
-0.007593499030917883,
-0.030031340196728706,
-0.0018983747577294707,
-0.028978897258639336,
-0.05164313688874245,
0.024108288809657097,
-0.014061128720641136,
0.004078216850757599,
-0.022688714787364006,
0.032283078879117966,
0.012500820681452751,
-0.007373220287263393,
0.006516580935567617,
-0.017964959144592285,
0.03382503241300583,
0.010034922510385513,
0.014905530959367752,
-0.027192192152142525,
0.011478972621262074,
-0.024438707157969475,
-0.028978897258639336,
-0.014220219105482101,
-0.025087306275963783,
0.056929826736450195,
-0.0026586425956338644,
-0.00714682275429368,
-0.02560129016637802,
0.004959332291036844,
-0.005779258441179991,
0.019678238779306412,
-0.030031340196728706,
-0.01601916365325451,
0.015774408355355263,
-0.013388055376708508,
-0.019861804321408272,
0.03759424760937691,
0.0252341590821743,
0.036590754985809326,
-0.0021125348284840584,
0.006706265266984701,
0.024083813652396202,
0.042709607630968094,
0.011228099465370178,
-0.025919470936059952,
-0.0009377145324833691,
0.0052040861919522285,
-0.0032154584769159555,
-0.001074623898603022,
0.007752589415758848,
-0.00506029324606061,
-0.028929946944117546,
-0.02322717383503914,
0.02910127490758896,
0.032283078879117966,
-0.018662508577108383,
-0.016166014596819878,
-0.0064247976988554,
-0.019837329164147377,
-0.021624034270644188,
0.04285646229982376,
-0.0020069845486432314,
0.015713220462203026,
0.00982076209038496,
0.013804136775434017,
-0.0049470942467451096,
-0.03475509583950043,
-0.010701877996325493,
0.028391487896442413,
0.009037548676133156,
-0.021036623045802116,
-0.04459421709179878,
0.003906888887286186,
-0.028880996629595757,
-0.023704444989562035,
0.004806360695511103,
-0.024793600663542747,
0.01163194328546524,
-0.02194221504032612,
-0.003683550748974085,
-0.004852252081036568,
-0.010952750220894814,
0.00443005096167326,
0.020596066489815712,
-0.002468958031386137,
0.03519565612077713,
-0.01725517213344574,
-0.03597886860370636,
0.01565203070640564,
-0.014599588699638844,
-0.008315524086356163,
-0.016900278627872467,
0.025894995778799057,
-0.021587321534752846,
-0.05360117182135582,
0.04520610347390175,
-0.014575112611055374,
-0.017952721565961838,
0.0005193378310650587,
-0.024818075820803642,
0.025136256590485573,
0.02266423963010311,
0.02469570003449917,
-0.0037172045558691025,
-0.0330418162047863,
-0.01188893523067236,
-0.0010111407609656453,
0.013437005691230297,
-0.036370474845170975,
0.005901635624468327,
0.029566308483481407,
0.0027320687659084797,
-0.027339044958353043,
-0.004812479484826326,
0.005418246146291494,
-0.009649434126913548,
-0.0032307554502040148,
-0.003965018317103386,
-0.004423932172358036,
0.0014126907335594296,
0.02304360829293728,
0.004885905887931585,
0.0027947870548814535,
-0.0172062199562788,
0.005877160467207432,
0.001713279401883483,
0.012500820681452751,
0.017610065639019012,
0.0033408948220312595,
-0.01620272919535637,
-0.004720696713775396,
-0.029566308483481407,
-0.006822523660957813,
-0.00010296885739080608,
0.06500671803951263,
-0.01715726964175701,
-0.02303137071430683,
0.02963973395526409,
-0.008866220712661743,
-0.029125750064849854,
-0.012996448203921318,
0.009502582252025604,
-0.01287407148629427,
0.014624063856899738,
-0.0072141303680837154,
0.043664149940013885,
0.037741098552942276,
-0.01329015288501978,
0.0067001464776694775,
0.043076738715171814,
-0.02166074700653553,
0.004592200741171837,
0.025503387674689293,
0.027461422607302666,
0.002666291082277894,
0.008596991188824177,
0.004895084071904421,
0.0007690635975450277,
-0.007018326781690121,
0.020033132284879684,
0.029811061918735504,
0.03345790132880211,
0.01447721105068922,
0.03316419571638107,
0.024634510278701782,
-0.009563770145177841,
0.005990359000861645,
-0.019666001200675964,
-0.019347820430994034,
-0.03561173751950264,
-0.015529653988778591,
-0.026188699528574944,
0.0096371965482831,
-0.036101244390010834,
0.005032758228480816,
0.0021431290078908205,
0.025527862831950188,
0.039356477558612823,
-0.029957914724946022,
-0.0017499926034361124,
0.023337313905358315,
0.01486881822347641,
0.003683550748974085,
0.021783124655485153,
-0.015150285325944424,
-0.015566367655992508,
0.00791779812425375,
0.009808524511754513,
0.0070672775618731976,
0.009875832125544548,
0.007495597470551729,
0.00958824623376131,
0.026825061067938805,
0.014954482205212116,
-0.012243828736245632,
-0.014342596754431725,
-0.04799630120396614,
-0.003965018317103386,
-0.005305047612637281,
-0.02675163373351097,
-0.006388084962964058,
-0.0017239873996004462,
-0.02946840599179268,
-0.011007820256054401,
0.010132824070751667,
0.00033691947464831173,
-0.008523564785718918,
-0.0013002566993236542,
-0.005861863028258085,
-0.006027072202414274,
0.022052353248000145,
0.01484434213489294,
-0.03987045958638191,
0.027877504006028175,
0.01106289029121399,
0.023019133135676384,
0.02753484807908535,
0.023826822638511658,
-0.043027788400650024,
0.002016162732616067,
-0.013094349764287472,
0.02142823114991188,
-0.015297138132154942,
-0.00026578776305541396,
0.0019779198337346315,
-0.005981180816888809,
0.051838941872119904,
0.014795391820371151,
0.01772020384669304,
-0.011185267008841038,
-0.030276095494627953,
-0.012959735468029976,
0.03340894728899002,
0.005696654319763184,
0.038206130266189575,
0.015566367655992508,
-0.03037399612367153,
-0.011485091410577297,
-0.01121586188673973,
-0.005913873668760061,
-0.027779601514339447,
-0.002091118833050132,
0.022566337138414383,
0.015505178831517696,
-0.026996389031410217,
-0.024818075820803642,
-0.016227204352617264,
0.02486702799797058,
0.018319852650165558,
0.0066022444516420364,
-0.001031791907735169,
0.01429364550858736,
-0.013779661618173122,
0.004197534639388323,
0.029346028342843056,
0.013033161871135235,
0.022737665101885796,
-0.008364475332200527,
0.03198937326669693,
-0.03634599968791008,
0.030496373772621155,
0.03512222692370415,
0.016484195366501808,
-0.010744709521532059,
-0.0117053696885705,
0.009429155848920345,
0.00022142607485875487,
-0.010181775316596031,
0.025307584553956985,
0.03230755403637886,
-0.019017402082681656,
-0.025503387674689293,
0.047971826046705246,
-0.00633301492780447,
-0.015321613289415836,
-0.009110975079238415,
-0.018968451768159866,
-0.010799779556691647,
0.0019335582619532943,
-0.0003919891605619341,
-0.01757335104048252,
-0.018197475001215935,
0.009551532566547394,
0.012653792276978493,
-0.02399815060198307,
-0.00714682275429368,
-0.009857475757598877,
-0.03005581721663475,
0.0034051428083330393,
0.022272633388638496,
-0.04459421709179878,
-0.06520251929759979,
-0.02596842125058174,
0.03147539123892784,
-0.04033549129962921,
-0.011240337044000626,
-0.007648569066077471,
-0.007189654745161533,
0.03404530882835388,
-0.026971913874149323,
-0.014856580644845963,
0.010744709521532059,
0.03056980110704899,
0.01085484866052866,
0.00690818764269352,
0.017634540796279907,
0.03402083367109299,
-0.03255230933427811,
-0.020583828911185265,
-0.004304614383727312,
-0.006859236396849155,
0.05115363001823425,
-0.02910127490758896,
0.0204247385263443,
0.0010509133571758866,
-0.036003343760967255,
0.014232456684112549,
-0.01734083518385887,
-0.010781423188745975,
0.01702265441417694,
-0.013669522479176521,
-0.006657314486801624,
-0.01807509735226631,
0.0037539175245910883,
-0.0016750366194173694,
0.020436976104974747,
0.021770887076854706,
-0.0027075933758169413,
0.0023817643523216248,
0.01945795863866806,
0.03901382163167,
-0.0016444423235952854,
-0.05007671192288399,
-0.00022601521050091833,
0.042293526232242584,
0.0018815479706972837,
0.00563240610063076,
0.03429006412625313,
0.013583858497440815,
-0.04745784029364586,
-0.007599618285894394,
0.004133286420255899,
-0.0353425070643425,
-0.023618780076503754,
-0.011503447778522968,
0.008670417591929436,
0.0033959646243602037,
0.0042464854195714,
-0.005308107007294893,
0.0025821567978709936,
-0.019152017310261726,
0.0008352237055078149,
-0.011662538163363934,
-0.004035384859889746,
-0.011699250899255276,
0.0052499775774776936,
0.00526527501642704,
-0.0022318523842841387,
-0.004053741693496704,
0.02234605886042118,
-0.0024429529439657927,
-0.01643524505198002,
-0.013902039267122746,
-0.009013073518872261,
-0.021599559113383293,
-0.0040200878866016865,
-0.021672984585165977,
0.010610095225274563,
0.011466734111309052,
-0.0038671165239065886,
-0.04540190473198891,
-0.012568128295242786,
-0.00009584613144397736,
0.0027198311872780323,
-0.03468167036771774,
0.010249081999063492,
-0.004069038666784763,
-0.03835298493504524,
0.028856521472334862,
0.05164313688874245,
0.01615377701818943,
0.021513894200325012,
-0.05242634937167168,
0.0003053691179957241,
-0.013314628973603249,
0.0344124399125576,
-0.011099603027105331,
-0.014416022226214409,
0.01261707954108715,
0.01715726964175701,
-0.023643257096409798,
-0.04601379111409187,
-0.002774900756776333,
-0.0060484884306788445,
0.00718353595584631,
-0.0037936901208013296,
0.003955839667469263,
-0.01115467306226492,
-0.01808733493089676,
0.005301987752318382,
-0.011179148219525814,
0.0063697281293570995,
0.028562815859913826,
0.013767424039542675,
0.00131631875410676,
0.037325017154216766,
-0.014048891142010689,
-0.004732934292405844,
-0.012133689597249031,
0.009227233938872814,
-0.024010388180613518,
-0.0007820661994628608,
0.028758618980646133,
-0.008805032819509506,
0.004010909702628851,
0.030300570651888847,
-0.009159926325082779,
-0.043615199625492096,
-0.0050939470529556274,
-0.03781452402472496,
-0.012054144404828548,
0.008823389187455177,
-0.03037399612367153,
0.027779601514339447,
-0.022407246753573418,
0.027241142466664314,
-0.007403814699500799,
0.021966690197587013,
-0.03355580195784569,
0.042244575917720795,
-0.019837329164147377,
-0.031132735311985016,
-0.004023147281259298,
-0.008064650930464268,
-0.02468346245586872,
0.02726561762392521,
0.000044720225560013205,
-0.011870578862726688,
0.020987672731280327,
-0.0038640571292489767,
-0.008456258103251457,
0.004965451080352068,
-0.036052294075489044,
-0.02423066645860672,
0.0011220450978726149,
-0.025870518758893013,
-0.0008589343051426113,
0.03318867087364197,
0.04016416519880295,
-0.0011556987883523107,
0.04919559508562088,
0.01656986027956009,
-0.03539145737886429,
0.03137749060988426,
-0.01770796626806259,
-0.004690102301537991,
-0.0358075387775898,
-0.0017622302984818816,
0.0798388198018074,
-0.0012826650636270642,
0.0022043175995349884,
0.016533145681023598,
-0.014318120665848255,
-0.007336507085710764,
0.014048891142010689,
-0.001941206748597324,
0.000560640124604106,
-0.027094289660453796,
0.002973763504996896,
0.026457929983735085,
0.04505924880504608,
0.01615377701818943,
0.025625765323638916,
-0.004017028491944075,
0.004500417970120907,
0.025674715638160706,
-0.00474823173135519,
-0.007795421406626701,
0.009227233938872814,
0.022358296439051628,
-0.04346834868192673,
0.0158355962485075,
-0.0139999408274889,
-0.004475942347198725,
-0.015517416410148144,
-0.00021702813683077693,
-0.017475450411438942,
-0.008364475332200527,
0.00956988986581564,
0.016912516206502914,
0.01002880372107029,
-0.0012069442309439182,
0.006510461680591106,
0.021587321534752846,
-0.011075127869844437,
-0.0033684298396110535,
0.004806360695511103,
0.022921230643987656,
-0.00655329367145896,
0.003163448069244623,
0.00009522468462819234,
0.031083783134818077,
0.012500820681452751,
-0.033751603215932846,
-0.024622272700071335,
-0.014379309490323067,
0.006510461680591106,
0.0032919440418481827,
0.006290182936936617,
-0.01964152418076992,
0.03754529356956482,
-0.001105218194425106,
-0.036884456872940063,
-0.0247813630849123,
0.008927409537136555,
-0.0021002970170229673,
-0.0034173806197941303,
-0.025087306275963783,
-0.031818047165870667,
0.01429364550858736,
0.01198071800172329,
0.011007820256054401,
0.02111005038022995
] | 2024-12-24 | 26 | 39717765 | [
"T cell therapy",
"autologous hematopoietic stem cell transplantation",
"refractory BL",
"tandem anti-CD19/CD22 CAR T cell therapy",
"myeloablative ASCT",
"BL",
"sustained complete remission",
"multiple chemoimmunotherapy regimens",
"tandem anti-CD19/CD22 chimeric antigen receptor",
"signaling domains",
"ASCT",
"further clinical validation",
"CAR",
"R/R BL",
"a novel third-generation CAR T cells",
"CD3ζ",
"a novel therapeutic strategy",
"CD28",
"infusion",
"Asian",
"Burkitt",
"third",
"a TLR2 costimulatory domain",
"relapsed/refractory (R/R) Burkitt lymphoma",
"an effective approach",
"any severe complications",
"whose lymphoma",
"the 306-day follow-up",
"A 20-year-old Asian male",
"306-day"
] | [
"CAR T-cell therapy",
"CD19/CD22 dual target",
"autologous hematopoietic stem cell transplantation",
"immunotherapy",
"relapsed/refractory Burkitt lymphoma"
] | 0 | 10.3389/fimmu.2024.1497736
10.1002/ajh.24720
10.1080/10428194.2022.2133542
10.1056/NEJMoa1707447
10.1056/NEJMoa1804980
10.1038/nm.4441
10.1200/JCO.19.03279
10.1080/14712598.2022.2086043
10.1182/blood.2022018598
10.1007/s00432-020-03198-7
10.1182/bloodadvances.2021004557
10.1038/leu.2017.249
10.1186/s13045-018-0572-x
10.1186/s40364-020-00198-0
10.1016/j.bbmt.2012.11.016
10.2147/BLCTT.S407804
10.1056/NEJMc2030164
10.1200/JCO.22.00642
10.1016/S0140-6736(21)01222-8
10.3390/cancers16091722
10.1007/s13402-024-00940-y
10.1182/blood.2021012634
10.1016/j.ymthe.2021.10.004
10.1182/bloodadvances.2022007779
10.1136/jitc-2024-008857
10.1182/bloodadvances.2020002509 | [
"Luo",
"Chen",
"Qin",
"Weinkove",
"Zhao",
"Ye",
"Chen",
"Tang",
"Liu",
"Huang",
"Shi",
"Yuan",
"Tan",
"Qin",
"Tang",
"Li",
"Zheng"
] | [
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"China-New Zealand Joint Laboratory on Biomedicine and Health, Key Laboratory of Immune Response and Immunotherapy, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong- Hong Kong Stem Cell and Regenerative Medicine Research Centre, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.",
"Cancer Immunotherapy Program, Malaghan Institute of Medical Research, Wellington, New Zealand.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.",
"Department of Automation, Tsinghua University, Beijing, China.",
"China-New Zealand Joint Laboratory on Biomedicine and Health, Key Laboratory of Immune Response and Immunotherapy, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong- Hong Kong Stem Cell and Regenerative Medicine Research Centre, GIBH-CUHK Joint Research Laboratory on Stem Cell and Regenerative Medicine, Institute of Drug Discovery, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.",
"The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China."
] | [
"39717765",
"28295472",
"36260003",
"29226797",
"30501490",
"29155426",
"32286905",
"35653589",
"36821767",
"32222815",
"34521107",
"28841215",
"29458388",
"32514352",
"23200705",
"38510818",
"33596362",
"36399695",
"34097852",
"38730674",
"38564164",
"34496014",
"34628052",
"36044388",
"38631712",
"32780846"
] | [] | 6.496071 | 5.791145 |
39717204 | 97 | A GD (Gamma-Delta) type of cancel culture. | γδ T cells represent an 'unconventional' class of CD3+ lymphocytes with unique phenotypical and functional attributes that distinguishes them from their αβ T-cell receptor-expressing counterparts. Studies investigating the roles of γδ T cells in cancer have shown that these cells are indispensable for effective tumor control and their presence within the tumor may be of prognostic significance. Currently, there is significant interest in harnessing γδ T cells for cancer treatment, and research efforts have focused on the development of γδ T-cell-based strategies that are efficacious against cancer. Several therapeutic approaches using γδ T cells have been described, premised on the expansion of γδ T cells or γδ chimeric antigen receptor T therapy. The potential for broad, unbiased and 'off-the-shelf' applicability in cancer treatment, drives ongoing and future research and methodologies by which γδ T cells can be exploited for therapeutic use. In this review, we will briefly outline the characteristics of γδ T cells and describe how these work within and promote proper functioning of the cancer-immunity cycle. Additionally, we will introduce strategies that are less commonly described and may potentially be more efficacious than other types of therapy. Our discussion will expand upon presently known applications and even highlight the versatility of this immune subset as cancer therapeutics. γδ T-cell-based treatment is an emerging strategy and should be considered for cancelling cancer. | [
0.010538208298385143,
0.04704814404249191,
0.03322609141469002,
0.04540899023413658,
-0.008190231397747993,
-0.007691839709877968,
0.02207319810986519,
0.043947041034698486,
0.014442273415625095,
0.030501550063490868,
-0.014209691435098648,
0.006013922393321991,
0.02531827986240387,
0.008555717766284943,
0.04939612001180649,
-0.04558619484305382,
0.01155160367488861,
-0.02467590942978859,
0.047801267355680466,
0.07867938280105591,
0.020278990268707275,
0.01793101243674755,
-0.016469065099954605,
-0.013966033235192299,
-0.03238436207175255,
-0.009264541789889336,
0.008256683126091957,
0.04279520362615585,
-0.0227487962692976,
-0.052452921867370605,
0.02996993251144886,
-0.008705235086381435,
-0.00539647089317441,
-0.02042296901345253,
0.012249351479113102,
0.010300087742507458,
0.0484657883644104,
0.04687093570828438,
-0.007780442479997873,
0.044833071529865265,
0.002619323320686817,
0.032118555158376694,
-0.0017263722838833928,
0.05103527382016182,
-0.015516583807766438,
-0.01777595840394497,
-0.0049949889071285725,
-0.06468012183904648,
-0.015261850319802761,
-0.008123778738081455,
-0.00788565818220377,
-0.016701648011803627,
-0.016823476180434227,
0.05147828906774521,
-0.040336474776268005,
0.010864931158721447,
-0.06007276847958565,
0.018872419372200966,
-0.009530349634587765,
-0.0034333625808358192,
-0.01661304570734501,
-0.013932807371020317,
0.04554189369082451,
0.007852432318031788,
-0.04184272140264511,
0.025384733453392982,
-0.026913132518529892,
0.019880276173353195,
-0.021873842924833298,
-0.045032426714897156,
0.027621956542134285,
-0.02833077870309353,
0.030080687254667282,
-0.021475128829479218,
0.03307103365659714,
0.01632508635520935,
0.002198459580540657,
0.004053582902997732,
0.03116607293486595,
-0.049927737563848495,
0.05431358143687248,
0.011872789822518826,
0.0024019693955779076,
-0.02611570619046688,
0.006340645253658295,
0.006290806457400322,
0.048642996698617935,
-0.032915979623794556,
-0.06605346500873566,
0.025894198566675186,
0.011917090974748135,
-0.02640366554260254,
-0.01295817457139492,
0.046117812395095825,
-0.020234689116477966,
-0.009674330241978168,
0.017266491428017616,
-0.021774163469672203,
0.037124618887901306,
0.025982802733778954,
0.03311533480882645,
0.008727386593818665,
-0.028109271079301834,
-0.005501686595380306,
0.0573703832924366,
-0.04558619484305382,
-0.07327460497617722,
0.001144915702752769,
0.03129897639155388,
0.017587676644325256,
0.05484519898891449,
0.026824530214071274,
0.00986814871430397,
0.030745208263397217,
-0.020766306668519974,
-0.041909173130989075,
-0.010820630006492138,
-0.022006746381521225,
0.014010334387421608,
-0.0009455591207370162,
-0.028220025822520256,
0.03366910293698311,
-0.015073569491505623,
-0.041266802698373795,
-0.026713775470852852,
-0.05050365626811981,
0.05147828906774521,
-0.040868088603019714,
-0.005792414769530296,
-0.009569114074110985,
0.02418859302997589,
-0.016280783340334892,
0.01572701521217823,
0.0007070926949381828,
-0.03699171170592308,
-0.009175938554108143,
-0.004355386830866337,
0.004344311077147722,
-0.035773422569036484,
0.002725923666730523,
0.030700907111167908,
-0.07770475000143051,
0.01372237503528595,
0.00584779167547822,
0.012891722843050957,
-0.049086008220911026,
-0.04115604981780052,
0.0583450123667717,
-0.011169503442943096,
0.02735614776611328,
-0.02591634914278984,
0.019071776419878006,
0.05325034633278847,
-0.03174199163913727,
-0.04084593802690506,
-0.005313405301421881,
-0.010676650330424309,
0.058832328766584396,
-0.06273085623979568,
-0.040336474776268005,
-0.04855439439415932,
0.03032434545457363,
-0.007055006455630064,
0.01121380552649498,
0.009253465570509434,
-0.013235058635473251,
-0.029394013807177544,
0.004125572741031647,
-0.03719107061624527,
0.014364746399223804,
0.007414955645799637,
-0.019802749156951904,
-0.043703384697437286,
0.026647323742508888,
-0.05426928028464317,
-0.011651282198727131,
0.029792727902531624,
0.0489531047642231,
-0.04766836389899254,
-0.03428932651877403,
0.007088232319802046,
0.006683981511741877,
0.001528400112874806,
-0.023701276630163193,
-0.02186276763677597,
-0.011385473422706127,
-0.004870390985161066,
-0.015350453555583954,
-0.043548326939344406,
-0.005116818007081747,
0.0032616944517940283,
-0.010205946862697601,
0.032915979623794556,
0.04554189369082451,
0.00521649606525898,
-0.015583036467432976,
0.03437792882323265,
0.03253941610455513,
0.007270975969731808,
-0.011335634626448154,
0.047358252108097076,
-0.017033908516168594,
-0.03871947154402733,
-0.023169659078121185,
-0.029261110350489616,
-0.010543745942413807,
0.014121088199317455,
0.05107957497239113,
-0.04120035097002983,
-0.027932066470384598,
0.013046777807176113,
-0.029659822583198547,
-0.025539787486195564,
0.013179682195186615,
-0.022770946845412254,
-0.013689149171113968,
0.003267232095822692,
0.04321606829762459,
0.014121088199317455,
0.013467641547322273,
-0.01404356025159359,
0.02799851819872856,
-0.004776250571012497,
-0.024543004110455513,
-0.023014605045318604,
-0.0003068221849389374,
0.017787033692002296,
-0.03758978471159935,
-0.0016682265559211373,
-0.017122510820627213,
-0.02651442028582096,
-0.02764410711824894,
-0.0024905723985284567,
-0.055066704750061035,
-0.04855439439415932,
-0.02210642583668232,
0.023081056773662567,
0.011850638315081596,
0.05099097266793251,
-0.024055689573287964,
-0.0045713563449680805,
0.018196821212768555,
0.020522648468613625,
0.0030180364847183228,
-0.05697166919708252,
0.011584829539060593,
-0.00323954364284873,
-0.0865650400519371,
-0.01179526187479496,
0.029150355607271194,
-0.03493169695138931,
0.038409359753131866,
0.0009448669152334332,
-0.014929589815437794,
0.014896363951265812,
0.02888454683125019,
-0.012470859102904797,
-0.025694843381643295,
-0.009153787977993488,
0.03145403042435646,
-0.007376192137598991,
-0.01111412700265646,
-0.01043299213051796,
-0.0007219752296805382,
-0.06064869090914726,
0.031232524663209915,
0.015361528843641281,
-0.015715939924120903,
0.02013500966131687,
-0.007287588901817799,
0.04071303457021713,
0.013733450323343277,
0.07150254398584366,
-0.03927323967218399,
-0.046560827642679214,
0.0031758605036884546,
-0.02571699395775795,
0.03234006091952324,
0.029792727902531624,
0.006955327931791544,
-0.010167183354496956,
0.010006590746343136,
0.020411893725395203,
-0.0050088330172002316,
-0.02310320734977722,
-0.01179526187479496,
-0.02571699395775795,
-0.005473998375236988,
-0.023967085406184196,
-0.01617003045976162,
0.03774483874440193,
0.007874582894146442,
0.012016769498586655,
-0.020832758396863937,
-0.005343862809240818,
0.02684668079018593,
0.010964609682559967,
-0.02334686554968357,
-0.05905383825302124,
0.009292230010032654,
-0.052054207772016525,
0.008439427241683006,
-0.01837402768433094,
0.0009690942824818194,
-0.018385102972388268,
-0.018086068332195282,
-0.002094628056511283,
-0.044035643339157104,
0.010139495134353638,
0.015826694667339325,
0.04842148721218109,
-0.004355386830866337,
0.05196560546755791,
0.06755971908569336,
-0.004363693296909332,
-0.00022669884492643178,
-0.004961762577295303,
-0.03238436207175255,
-0.02992563135921955,
-0.027267543599009514,
-0.027333997189998627,
-0.022006746381521225,
-0.0036631764378398657,
0.002307828748598695,
-0.0007731987861916423,
-0.019049623981118202,
-0.04157691448926926,
-0.003923447337001562,
0.03603923320770264,
-0.018506931141018867,
0.018595535308122635,
-0.05196560546755791,
0.05116817727684975,
0.01641368865966797,
-0.04064658284187317,
-0.010017666034400463,
-0.018949946388602257,
0.019636619836091995,
0.029261110350489616,
0.03597278147935867,
-0.03734612464904785,
0.030988866463303566,
-0.035529766231775284,
0.03262801840901375,
0.02872949279844761,
0.01760982722043991,
-0.02363482490181923,
0.07402772456407547,
-0.006778122391551733,
0.03451083227992058,
0.015117870643734932,
0.016745949164032936,
0.014641630463302135,
-0.016513366252183914,
0.024897417053580284,
0.015383679419755936,
0.001644691452383995,
-0.06552185118198395,
0.03758978471159935,
0.005836716387420893,
-0.013312586583197117,
-0.008096090517938137,
-0.021851692348718643,
0.023125357925891876,
0.023457620292901993,
0.046516526490449905,
-0.052054207772016525,
0.004111728630959988,
-0.03194134682416916,
-0.03628288954496384,
0.0019548016134649515,
0.037124618887901306,
-0.0011345325037837029,
0.005487842485308647,
-0.045032426714897156,
0.007365116383880377,
0.020245764404535294,
0.009043034166097641,
0.01958124153316021,
0.03174199163913727,
0.04051367938518524,
-0.037456877529621124,
0.008550180122256279,
-0.02556193806231022,
-0.050769466906785965,
0.008068402297794819,
-0.01841832883656025,
-0.05657295510172844,
-0.09108378738164902,
0.004380306228995323,
-0.012991401366889477,
-0.03466588631272316,
0.0006565614021383226,
-0.0023355172015726566,
-0.05050365626811981,
0.011839563027024269,
-0.028995301574468613,
0.07274298369884491,
0.046472225338220596,
-0.0016917617758736014,
0.002458730712532997,
-0.03630504012107849,
-0.023612674325704575,
-0.0454975925385952,
0.018927795812487602,
-0.021918144077062607,
0.015272925607860088,
0.04279520362615585,
0.04815568029880524,
-0.027023887261748314,
0.005820103455334902,
0.06157901883125305,
0.03807709738612175,
0.014220766723155975,
-0.02458730712532997,
-0.03145403042435646,
-0.030435098335146904,
0.009092872962355614,
0.0007064004894345999,
0.02294815331697464,
0.027333997189998627,
-0.014774534851312637,
-0.029216809198260307,
-0.021851692348718643,
-0.02034544199705124,
0.01961446925997734,
0.002436579903587699,
0.03413426876068115,
-0.01865091174840927,
-0.06122460961341858,
-0.023014605045318604,
0.0697304904460907,
0.0044218385592103004,
0.007071619387716055,
-0.00011854100011987612,
0.021574808284640312,
-0.011972467415034771,
-0.04363693296909332,
-0.013013551943004131,
0.025694843381643295,
-0.03964979946613312,
0.0007918884512037039,
-0.01554980967193842,
-0.027112489566206932,
0.05302884057164192,
0.04979483410716057,
-0.00013247173046693206,
0.0009517890284769237,
-0.02635936439037323,
-0.046472225338220596,
0.04704814404249191,
-0.02294815331697464,
0.017078209668397903,
0.002584712812677026,
-0.025584088638424873,
-0.005797952879220247,
0.041466161608695984,
-0.06893306225538254,
0.00966879166662693,
-0.01597067341208458,
0.027976367622613907,
-0.019625544548034668,
-0.007398342713713646,
-0.017919937148690224,
-0.012094296514987946,
0.032317910343408585,
0.03085596114397049,
-0.03145403042435646,
0.030723057687282562,
-0.0030484937597066164,
0.04540899023413658,
-0.0113743981346488,
0.003992668353021145,
0.001171911833807826,
-0.02262696623802185,
0.01255946233868599,
0.01793101243674755,
0.006002847105264664,
0.01362269651144743,
0.05874372646212578,
0.005601365119218826,
-0.004889772739261389,
-0.000023059252271195874,
-0.011640206910669804,
0.024498702958226204,
-0.033314693719148636,
-0.04100099578499794,
-0.007104845717549324,
0.0099512143060565,
0.014973890967667103,
-0.012337954714894295,
-0.026735926046967506,
0.02025683969259262,
-0.007719528395682573,
0.01090923324227333,
0.03273877501487732,
0.006744896061718464,
-0.007891196757555008,
-0.027821311727166176,
0.030833810567855835,
-0.02759980596601963,
0.011169503442943096,
-0.013423340395092964,
0.04317176714539528,
0.06317387521266937,
0.011429774574935436,
-0.015715939924120903,
0.021452978253364563,
-0.03353619948029518,
0.006988554261624813,
-0.04489952325820923,
-0.029216809198260307,
0.036725904792547226,
-0.0034056741278618574,
-0.005842254031449556,
-0.006224354263395071,
-0.04961762577295303,
-0.008190231397747993,
-0.018063917756080627,
-0.015715939924120903,
0.022294705733656883,
0.023236112669110298,
-0.0014134931843727827,
-0.004352617543190718,
-0.017997466027736664,
-0.032273609191179276,
-0.02700173482298851,
0.007653076201677322,
-0.007182373199611902,
-0.03322609141469002,
-0.011961392126977444,
-0.021408677101135254,
-0.006135751027613878,
0.05156689137220383,
-0.012105371803045273,
-0.04445650801062584,
-0.013356887735426426,
0.01981382444500923,
-0.006146826781332493,
-0.023856332525610924,
-0.005753651261329651,
0.0025113385636359453,
0.04585200548171997,
0.006501238327473402,
0.009342068806290627,
0.04100099578499794,
-0.010150570422410965,
-0.030523700639605522,
-0.016912080347537994,
0.016391538083553314,
0.017266491428017616,
-0.058079205453395844,
0.01268129050731659,
-0.0338684618473053,
-0.0194151122123003,
0.0032700009178370237,
-0.013002476654946804,
0.006506775971502066,
-0.001184371649287641,
-0.02536258101463318,
-0.039539046585559845,
-0.03526395559310913,
-0.021596958860754967,
-0.00900980830192566,
0.021652335301041603,
0.027068188413977623,
0.004839933943003416,
-0.002134776208549738,
-0.020367592573165894,
0.035374708473682404,
-0.01989135332405567,
0.018628761172294617,
0.024543004110455513,
0.0034832018427550793,
0.013223983347415924,
0.0026013259775936604,
-0.03165338933467865,
-0.000960787758231163,
-0.03333684429526329,
0.03389061242341995,
-0.012105371803045273,
-0.007558935321867466,
-0.032273609191179276,
0.03245081380009651,
0.0061025251634418964,
-0.0021790778264403343,
-0.01696745678782463,
-0.01970307156443596,
0.004175412002950907,
-0.028818095102906227,
0.029438314959406853,
0.008073939941823483,
0.0074703325517475605,
-0.014530876651406288,
-0.03541901335120201,
0.015162172727286816,
-0.02037866786122322,
0.012171824462711811,
0.001817743992432952,
0.013223983347415924,
0.01814144477248192,
0.009513736702501774,
-0.03220715746283531,
-0.01777595840394497,
-0.028264326974749565,
0.01777595840394497,
-0.025982802733778954,
-0.022172877565026283,
0.011618056334555149,
0.006396022159606218,
0.051212478429079056,
0.0573703832924366,
-0.04722534865140915,
-0.031675539910793304,
0.037213221192359924,
-0.012526235543191433,
-0.007503558415919542,
0.008489266037940979,
-0.016114654019474983,
0.0004354002303443849,
-0.0044716778211295605,
0.011485151946544647,
-0.03329254314303398,
-0.01982489973306656,
0.024299347773194313,
-0.051611192524433136,
-0.0060859122313559055,
-0.02675807848572731,
-0.012393331155180931,
-0.024853115901350975,
-0.010898157022893429,
-0.04007066413760185,
-0.010560358874499798,
0.02839723229408264,
0.004801169969141483,
-0.007846894674003124,
0.004989451263099909,
-0.02174093760550022,
0.032317910343408585,
-0.00492576789110899,
0.000677327683661133,
0.03575127199292183,
-0.00028415228007361293,
-0.026625173166394234,
0.03121037408709526,
0.011529453098773956,
-0.0030734133906662464,
0.00019329969654791057,
0.019835975021123886,
0.0022344544995576143,
0.008649858646094799,
-0.019193604588508606,
0.04259584844112396,
-0.014962815679609776,
0.022494062781333923,
0.01965877041220665,
-0.006600916385650635,
-0.019647695124149323,
0.04594060778617859,
0.04020356759428978,
-0.02651442028582096,
-0.008539104834198952,
0.00030630300170741975,
-0.02872949279844761,
-0.002015716163441539,
-0.02022361382842064,
0.004903617314994335,
-0.019835975021123886,
0.007542322389781475,
-0.02872949279844761,
0.02483096532523632,
0.021441902965307236,
0.04979483410716057,
-0.003607799531891942,
-0.016336161643266678,
0.02343546785414219,
-0.005648435093462467,
-0.027954217046499252,
-0.00453536119312048,
0.020644476637244225,
-0.00160454330034554,
0.008893516846001148,
-0.010903694666922092,
-0.026447966694831848,
-0.0015353222843259573,
-0.01325721014291048,
-0.0054324655793607235,
0.005208189599215984,
0.013556244783103466,
-0.008721848949790001,
0.02010178379714489,
0.007437106221914291,
-0.018750589340925217,
-0.022006746381521225,
0.006672906223684549,
0.025163225829601288,
0.009369757026433945,
-0.03417856991291046,
-0.028773793950676918,
-0.003222930710762739,
0.021652335301041603,
0.029593370854854584,
-0.0050752852112054825,
-0.0029571219347417355,
0.014021409675478935,
-0.00808501522988081,
-0.026580872014164925,
-0.00844496488571167,
0.003317071357741952,
0.0003741396067198366,
-0.01330151129513979,
0.009702018462121487,
-0.0106932632625103,
-0.01588207110762596,
0.029017452150583267,
-0.025539787486195564,
-0.009823847562074661,
0.02438795007765293,
0.028507985174655914,
-0.006495700683444738,
0.005869942717254162,
-0.0012293653562664986,
-0.01813036948442459,
-0.01226042676717043,
0.05466799437999725,
0.043304670602083206,
-0.03727967292070389,
0.027068188413977623,
-0.031830593943595886,
-0.02403353899717331,
0.0013948035193607211,
-0.03408996760845184,
0.026913132518529892,
-0.026425816118717194,
-0.01330151129513979,
0.0420420803129673,
-0.016236482188105583,
-0.029881330206990242,
0.02487526647746563,
-0.011335634626448154,
0.04297240823507309,
-0.00657876580953598,
-0.018119294196367264,
-0.0015242468798533082,
-0.017687354236841202,
0.013179682195186615,
0.03428932651877403,
0.010361002758145332,
0.027333997189998627,
-0.031232524663209915,
0.005786877125501633,
0.006407097447663546,
-0.04979483410716057,
-0.005172194447368383,
0.04775696620345116,
-0.06171192228794098,
-0.004643346183001995,
-0.003397367661818862,
-0.02057802490890026,
-0.015782393515110016,
-0.011573754251003265,
-0.00615790206938982,
0.025096772238612175,
0.02912820503115654,
-0.006728283129632473,
0.031874895095825195,
-0.01572701521217823,
0.04306101053953171,
0.012581612914800644,
0.013866354711353779,
-0.01745477318763733,
-0.0016820707824081182,
0.008378512226045132,
-0.038852375000715256,
0.00802410114556551,
0.011651282198727131,
-0.011651282198727131,
-0.005559832323342562,
-0.0093919076025486,
0.007968723773956299,
0.028352929279208183,
-0.007808131165802479,
-0.034998148679733276,
-0.0018925026524811983,
0.0038099249359220266,
-0.0127366678789258,
0.022161802276968956,
0.019636619836091995,
-0.017067134380340576,
-0.02339116670191288,
0.0014577946858480573,
0.05028215050697327,
-0.03517535328865051,
0.05701597034931183,
-0.03521965444087982,
0.01399925909936428,
0.022881699725985527,
-0.08129316568374634,
-0.027068188413977623,
0.017233265563845634,
0.02025683969259262,
-0.028574436902999878,
0.0009317149524576962,
0.010543745942413807,
0.014165389351546764,
-0.0013948035193607211,
-0.008267758414149284,
-0.015915296971797943,
-0.027932066470384598,
0.02339116670191288,
-0.00818469375371933,
0.013135381042957306,
-0.008395125158131123,
-0.030479399487376213,
-0.04412424564361572,
-0.014309369027614594,
0.03803279623389244,
0.0313875786960125,
-0.0012812811182811856,
-0.011136277578771114,
-0.0031647849828004837,
0.009796158410608768,
-0.009735244326293468,
0.005881018005311489,
-0.03105531819164753,
-0.0023341327905654907,
-0.04073518514633179,
-0.021774163469672203,
0.012061070650815964,
-0.008832601830363274,
0.015583036467432976,
-0.02146405354142189,
-0.05050365626811981,
0.02354622259736061,
-0.002354899188503623,
0.013611621223390102,
0.01918252930045128,
0.0361056849360466,
-0.011983542703092098,
0.023036755621433258,
0.030723057687282562,
-0.01777595840394497,
-0.04410209506750107,
-0.04157691448926926,
0.0194151122123003,
-0.008544642478227615,
-0.007514634169638157,
0.021552657708525658,
-0.00876615010201931,
-0.049484722316265106,
0.0017706736689433455,
-0.006994091905653477,
-0.011440849862992764,
0.005252491217106581,
0.0430167093873024,
0.021209320053458214,
0.0023632056545466185,
-0.023524072021245956,
0.032960280776023865,
0.03041294775903225,
-0.011950316838920116,
-0.0254733357578516,
-0.0356183685362339,
-0.010604660026729107,
0.03714676946401596,
-0.019470488652586937,
-0.020976737141609192,
0.014575177803635597,
0.013534094206988811,
-0.03927323967218399,
0.020677702501416206,
-0.022815247997641563,
-0.010704338550567627,
-0.017875635996460915,
-0.015483357943594456,
-0.01512894593179226,
0.018318651244044304,
-0.0776604488492012,
-0.011042137630283833,
-0.031431879848241806,
0.032561566680669785,
0.016779175028204918,
0.004756868351250887,
-0.023967085406184196,
0.022438686341047287,
0.014940665103495121,
-0.011313483119010925,
0.006728283129632473,
-0.01263698935508728,
0.000057539971749065444,
0.0015256312908604741,
0.001817743992432952,
-0.06463582068681717,
-0.022405460476875305,
-0.006573228165507317,
-0.0036548699717968702,
-0.0026400897186249495,
0.04040292650461197,
-0.02452085353434086,
-0.043149616569280624,
-0.05480089783668518,
0.023213962092995644,
-0.032960280776023865,
0.02427719719707966,
-0.018086068332195282,
0.011906015686690807,
-0.029482616111636162,
0.009375294670462608,
-0.0027563809417188168,
0.0242328941822052,
-0.030147138983011246,
-0.019570166245102882,
-0.017155738547444344,
0.04321606829762459,
-0.02607140503823757,
0.007503558415919542,
-0.00641817320138216,
0.04726964980363846,
0.005102973431348801,
-0.011341172270476818,
0.02680237963795662,
-0.0006537925219163299,
0.0005686506628990173,
0.022327931597828865,
-0.0008576484397053719,
-0.040225718170404434,
-0.0011220726883038878,
0.019426187500357628,
-0.008721848949790001,
0.00503652123734355,
0.016302933916449547,
-0.006462474353611469,
0.03581772372126579,
-0.017155738547444344,
0.055952735245227814,
0.023457620292901993,
0.015383679419755936,
0.021120717748999596,
-0.01660197041928768,
-0.02037866786122322,
-0.014132163487374783,
0.011584829539060593,
-0.026137856766581535,
-0.028220025822520256,
-0.00431108521297574,
0.013312586583197117,
-0.02290385030210018,
-0.017764883115887642,
0.0007697377586737275,
0.04722534865140915,
-0.011828487738966942,
-0.003657638793811202,
0.03878592327237129,
0.018628761172294617,
0.006678443867713213,
-0.0012141367187723517,
0.006855649873614311,
0.009198089130222797,
0.0058256410993635654,
-0.03692525997757912,
-0.03670375421643257,
-0.0026830066926777363,
-0.016070352867245674,
0.004596275743097067,
0.03497599810361862,
0.0022566053085029125,
-0.0059197815135121346,
-0.007857969962060452,
-0.033159635961055756,
0.0375676304101944,
0.023612674325704575,
-0.035684820264577866,
0.03309318423271179,
0.008284371346235275,
0.01937081106007099,
-0.0013415033463388681,
0.007603236939758062,
-0.0324065126478672,
-0.008472653105854988,
0.025340430438518524,
0.035441163927316666,
0.030235741287469864,
-0.0361056849360466,
-0.008456040173768997,
-0.048598695546388626,
-0.00030024617444723845,
0.011352247558534145,
0.012337954714894295,
-0.0022026128135621548,
0.039339691400527954,
0.0037185531109571457,
0.02576129510998726,
-0.023302564397454262,
-0.026625173166394234,
0.013268285430967808,
-0.009740781970322132,
-0.023236112669110298,
-0.060604386031627655,
0.000652408110909164,
0.028618738055229187,
-0.019991030916571617,
-0.01095353439450264,
0.029349712654948235,
0.01684562675654888,
-0.023679126054048538,
-0.028463684022426605,
0.0358620248734951,
0.022206103429198265,
0.03723537176847458,
-0.016513366252183914,
0.011595905758440495,
0.0336248017847538,
-0.007525709457695484,
0.028264326974749565,
0.029438314959406853,
-0.04558619484305382,
-0.0010050892597064376,
-0.032162856310606,
-0.046117812395095825,
-0.0127366678789258,
-0.0022192259784787893,
0.011573754251003265,
0.02270449511706829,
0.0254733357578516,
0.04563049599528313,
-0.0005413083708845079,
0.00326446327380836,
-0.005781339481472969,
0.05825641006231308,
-0.0040480452589690685,
0.004950687289237976,
0.008478190749883652,
-0.013046777807176113,
0.01672379858791828,
-0.023236112669110298,
0.017299717292189598,
0.0049783759750425816,
0.049573324620723724,
0.04297240823507309,
0.016026049852371216,
-0.04261799901723862,
-0.015350453555583954,
0.016557667404413223,
0.049130313098430634,
-0.04208638146519661,
-0.019105002284049988,
-0.018916720524430275,
-0.025384733453392982,
0.011208267882466316,
0.003754548029974103,
0.03668160364031792,
0.022095350548624992,
0.037368275225162506,
0.007038393523544073,
-0.0035745734348893166,
0.021995671093463898,
0.030147138983011246,
0.03758978471159935,
0.017476923763751984,
-0.006722745485603809,
-0.02270449511706829,
0.002026791451498866,
-0.0004793555708602071,
-0.0012037535198032856,
-0.050370752811431885,
0.028175724670290947,
-0.015306152403354645,
0.02334686554968357,
0.03579557314515114,
-0.009569114074110985,
-0.013445490971207619,
0.004228020086884499,
-0.009890299290418625,
0.027023887261748314,
-0.04833288490772247,
-0.01404356025159359,
0.0004395534924697131,
-0.021918144077062607,
-0.014685931615531445,
-0.007846894674003124,
-0.0019298820989206433,
0.011418699286878109,
0.023324714973568916,
-0.024122141301631927,
-0.01877273991703987,
0.04246294125914574,
-0.017122510820627213,
-0.02010178379714489,
-0.011485151946544647,
-0.04489952325820923,
-0.020234689116477966,
-0.003804387291893363,
-0.04388058930635452,
0.021563732996582985,
-0.004773481748998165,
-0.009524811990559101,
-0.0015740860253572464,
0.02238330990076065,
0.062775157392025,
-0.0004520132497418672,
-0.012803119607269764,
0.006656293291598558,
0.02804281935095787,
-0.036172136664390564,
-0.06250935047864914,
0.014187539927661419,
-0.006661830935627222,
-0.03964979946613312,
0.011595905758440495,
0.007165759801864624,
0.022604815661907196,
0.013523018918931484,
0.010947996750473976,
-0.01382205355912447,
0.0032589256297796965,
-0.004917461425065994,
0.017942087724804878,
-0.012149673886597157,
-0.024454401805996895,
0.021054266020655632,
0.004839933943003416,
-0.03770053759217262,
-0.011407623998820782,
0.0005257336306385696,
-0.013312586583197117,
-0.015616262331604958,
-0.03351404890418053,
0.025163225829601288,
-0.007918884977698326,
0.00458520045503974,
-0.000014785176972509362,
0.015361528843641281,
0.019514789804816246,
-0.016757024452090263,
0.00924792792648077,
0.007204523775726557,
0.004997757729142904,
-0.014165389351546764,
0.005529375281184912,
0.008212381973862648,
0.03121037408709526,
0.002684391103684902,
0.003333684289827943,
-0.0014577946858480573,
-0.0012535926653072238,
-0.008516954258084297,
-0.013600545935332775,
0.050813768059015274,
-0.00474579306319356,
-0.0479784719645977,
0.0430167093873024,
0.024543004110455513,
0.04044722765684128,
0.017831334844231606,
-0.0025071853306144476,
0.014253992587327957,
0.007686302065849304,
-0.024786662310361862,
0.006191127933561802,
0.001198215875774622,
-0.011086438782513142,
-0.004446758423000574,
0.005720424931496382,
-0.0008050404721871018,
-0.021364375948905945,
-0.011341172270476818,
0.0012404406443238258,
-0.004815014079213142,
0.02174093760550022,
-0.03763408586382866,
-0.0008777225157245994,
0.005748113617300987,
0.0033419907558709383,
0.0563957504928112,
0.01263698935508728,
-0.005324481055140495,
0.036172136664390564,
-0.0031094083096832037,
0.014253992587327957,
-0.0010424685897305608,
-0.01169558335095644,
-0.01113073993474245,
-0.019116077572107315,
-0.00716022215783596,
-0.033403296023607254,
0.017964238300919533,
0.03772268816828728,
-0.011341172270476818,
-0.010460680350661278,
0.02005748264491558,
-0.02110964246094227,
-0.019038548693060875,
0.00992906279861927,
0.01155160367488861,
0.0047984011471271515,
-0.021774163469672203,
0.011141815222799778,
-0.018684137612581253,
-0.03519750386476517,
-0.004200331401079893,
-0.008212381973862648,
0.003250619163736701,
0.017399394884705544,
0.008140391670167446,
0.02182954177260399,
0.0010874621802940965,
0.020323291420936584,
-0.011219343170523643,
0.0049146926030516624,
-0.02443225122988224,
0.020035332068800926,
-0.00846157781779766,
-0.007248825393617153,
-0.002778531750664115,
-0.038940977305173874,
-0.028220025822520256,
-0.022217178717255592,
-0.005651203915476799,
-0.016314009204506874,
0.02720109187066555,
-0.01034992653876543,
-0.029261110350489616,
-0.007946573197841644,
-0.02447655238211155,
0.012182899750769138,
-0.013223983347415924,
-0.0025999415665864944,
0.021176094189286232,
-0.023058906197547913,
-0.013877429999411106,
-0.008140391670167446,
-0.03852011263370514,
0.02684668079018593,
-0.009181476198136806,
0.007021780125796795,
-0.004792863503098488,
0.02438795007765293,
0.007498020771890879,
0.03353619948029518,
0.04529823735356331,
0.000973247573710978,
0.0036548699717968702,
-0.03823215514421463,
0.006191127933561802,
0.008217919617891312,
-0.0011774495942518115,
0.01737724430859089,
0.023302564397454262,
0.01456410251557827,
0.00263316766358912,
0.012515160255134106,
0.00060568394837901,
-0.015760241076350212,
-0.02001318149268627,
-0.014375821687281132,
-0.0023216730915009975,
0.017820259556174278,
-0.022527288645505905,
-0.006301881745457649,
-0.00954696349799633,
0.0029128205496817827,
0.016114654019474983,
0.023258263245224953,
-0.012581612914800644,
-0.0013920346973463893,
0.004175412002950907,
-0.01745477318763733,
0.010493907146155834,
0.00844496488571167,
0.010255786590278149,
0.013744525611400604,
-0.009630028158426285,
-0.008611095137894154,
0.04015926644206047,
0.023701276630163193,
0.01193924155086279,
-0.024255044758319855,
-0.03262801840901375,
0.00965217873454094,
-0.011202730238437653,
-0.012814194895327091,
0.007021780125796795,
0.017631977796554565,
0.022416535764932632,
-0.05068086087703705,
0.05356045812368393,
0.01672379858791828,
0.004288934636861086,
-0.006700594909489155,
-0.022516213357448578,
-0.026735926046967506,
0.008616632781922817,
0.011928166262805462,
0.006119138095527887,
-0.007946573197841644,
0.012858496978878975,
-0.05085806921124458,
-0.005814565811306238,
-0.008456040173768997,
0.004922999069094658,
-0.0018094375263899565,
-0.00030907185282558203,
-0.004610119853168726,
-0.01106982585042715,
-0.06153471767902374,
-0.03832075744867325,
0.020046407356858253,
-0.0336248017847538,
0.015394754707813263,
-0.018551234155893326,
0.032517265528440475,
0.022438686341047287,
-0.007929960265755653,
-0.018506931141018867,
0.041665516793727875,
-0.02334686554968357,
-0.012891722843050957,
0.04248509183526039,
0.02957122027873993,
0.05559832230210304,
-0.026935283094644547,
-0.03154263272881508,
-0.021774163469672203,
-0.01737724430859089,
0.01673487387597561,
0.02091028541326523,
0.01865091174840927,
0.012504084967076778,
-0.004491059575229883,
0.019647695124149323,
-0.01320183277130127,
-0.04401349276304245,
0.01909392699599266,
-0.016026049852371216,
-0.0187838152050972,
0.0061523644253611565,
-0.017421547323465347,
0.00031478257733397186,
-0.0007981183589436114,
0.05152259021997452,
-0.01777595840394497,
0.01568271405994892,
0.019149303436279297,
0.040181417018175125,
-0.0026567026507109404,
0.004563049878925085,
-0.003635487984865904,
0.012061070650815964,
-0.006462474353611469,
0.012825271114706993,
0.014630555175244808,
-0.03413426876068115,
-0.020688777789473534,
0.012758818455040455,
-0.00010409110836917534,
-0.04020356759428978,
0.0035856489557772875,
0.04445650801062584,
-0.007974261417984962,
0.032517265528440475,
0.024055689573287964,
0.008433888666331768,
-0.002882363274693489,
0.007088232319802046,
-0.011263644322752953,
-0.017665203660726547,
0.0016280784038826823,
0.019116077572107315,
-0.035640519112348557,
-0.014685931615531445,
-0.008910129778087139,
-0.01701175794005394,
-0.032229308038949966,
0.02030114084482193,
0.0019437262089923024,
-0.012171824462711811,
-0.02290385030210018,
0.005094666965305805,
0.008151466958224773,
0.00258332840166986,
-0.002736999187618494,
-0.021774163469672203,
0.029792727902531624,
0.004108959808945656,
-0.023014605045318604,
-0.00850587897002697,
-0.009696480818092823,
-0.0697304904460907,
-0.002725923666730523,
0.02222825400531292,
-0.01414323877543211,
0.01263698935508728,
0.01716681383550167,
-0.012349030002951622,
-0.01568271405994892,
-0.04104529693722725,
0.012847421690821648,
0.02242761105298996,
0.029482616111636162,
-0.006545539479702711,
-0.011042137630283833,
0.02045619674026966,
0.004219713620841503,
-0.017321867868304253,
-0.011158428154885769,
-0.033802010118961334,
0.0031149459537118673,
-0.023856332525610924,
0.004947918467223644,
-0.0027674564626067877,
0.0009061031742021441,
0.02848583459854126,
0.040225718170404434,
-0.046560827642679214,
0.0018260505748912692,
-0.010588047094643116,
0.015671638771891594,
0.02452085353434086,
0.007918884977698326,
-0.04306101053953171,
-0.01017272099852562,
-0.01873951405286789,
0.06304096430540085,
-0.023967085406184196,
0.015239699743688107,
-0.011307945474982262,
0.03535255789756775,
-0.028574436902999878,
0.02130899950861931,
0.016834551468491554,
-0.022117501124739647,
-0.0006326801376417279,
-0.004792863503098488,
-0.019880276173353195,
0.0006783659919165075,
-0.029903480783104897,
0.052054207772016525,
-0.00011257068399572745,
0.026536570861935616,
0.0012425172608345747,
-0.018673062324523926,
-0.021674485877156258,
0.02928326092660427,
-0.014353671111166477,
-0.0018994248239323497,
-0.0016516135074198246,
-0.01382205355912447,
-0.01881704293191433,
-0.019392961636185646,
-0.006888875737786293,
0.02174093760550022,
0.020954586565494537,
0.037656236439943314,
-0.0074703325517475605,
-0.013545169495046139,
-0.016701648011803627,
0.008228994905948639,
0.055022403597831726,
-0.00318416696973145,
0.008699697442352772,
-0.0024698060005903244,
0.0028435995336622,
-0.010720951482653618,
0.01793101243674755,
0.013168606907129288,
-0.004997757729142904,
-0.009175938554108143,
-0.011994617991149426,
0.0195369403809309,
-0.01736616902053356,
-0.01155160367488861,
0.08470437675714493,
0.0007572779431939125,
-0.008157004602253437,
0.024099990725517273,
-0.02319181151688099,
-0.006938714999705553,
0.026182157918810844,
0.010106269270181656,
0.016867777332663536,
-0.004106190986931324,
0.0033447598107159138,
-0.00007224943692563102,
0.013168606907129288,
0.020467272028326988,
0.019625544548034668,
0.0029571219347417355,
0.024410100653767586,
0.028153574094176292,
0.01101444847881794,
0.004457833711057901,
0.0055321441031992435,
0.016834551468491554,
-0.0002763649099506438,
0.017188964411616325,
-0.01446442399173975,
0.017842410132288933,
-0.009801696054637432,
-0.02551763691008091,
0.016989607363939285,
-0.004964531399309635,
0.019902428612113,
-0.0010182411642745137,
0.03358050063252449,
-0.033957064151763916,
0.005343862809240818,
-0.027511201798915863,
0.009181476198136806,
-0.030036384239792824,
0.002579175168648362,
0.015151096507906914,
0.03245081380009651,
0.041023146361112595,
-0.005720424931496382,
-0.016302933916449547,
0.008062864653766155,
0.031276825815439224,
-0.010477293282747269,
0.007187910843640566,
0.013467641547322273,
-0.009048571810126305,
0.008577869273722172,
0.018230047076940536,
0.0024047382175922394,
-0.01466378103941679,
-0.0013380423188209534,
-0.015638412907719612,
0.020312216132879257,
-0.005886555649340153,
0.00918701384216547,
-0.019160378724336624,
-0.01432044431567192,
0.020888134837150574,
0.017997466027736664,
0.00056692014914006,
0.012005694210529327
] | 2024-12-24 | 87 | 39717204 | [
"γδ T cells",
"cancer treatment",
"γδ chimeric antigen receptor T therapy",
"cancer therapeutics",
"cancer",
"effective tumor control",
"γδ T-cell-based treatment",
"γδ T-cell-based strategies",
"research efforts",
"strategies",
"Several therapeutic approaches",
"proper functioning",
"therapeutic use",
"these cells",
"their αβ T-cell receptor-expressing counterparts",
"significant interest",
"prognostic significance",
"other types",
"unique phenotypical and functional attributes",
"CD3",
"therapy",
"ongoing and future research",
"methodologies",
"the cancer-immunity cycle",
"an emerging strategy",
"presently known applications",
"Studies",
"this immune subset",
"the tumor",
"the versatility"
] | [
"T-cell product manufacturing/scalability",
"T-cell therapy for patients with solid tumors",
"tumor-infiltrating lymphocytes (TIL)"
] | 0 | 10.1016/j.iotech.2024.100740 | [
"Lim",
"Iyer"
] | [
"Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.\nCancer Therapeutics Research Laboratory, National Cancer Centre, Singapore.",
"Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore.\nCancer Therapeutics Research Laboratory, National Cancer Centre, Singapore.\nDepartment of Head and Neck Surgery, Singapore General Hospital, Singapore, Singapore."
] | [
"39717204",
"37933232",
"37654012",
"36851283",
"37327346",
"36624304",
"29707004",
"37345160",
"37368791",
"33526858",
"37063836",
"32939032",
"37820582",
"31285310",
"37989744",
"31611377",
"28270598",
"26755823",
"24076636",
"28783722",
"29025772",
"38594286",
"35296095",
"29091951",
"35589842",
"33936118",
"31597756",
"31689241",
"36754452",
"25363527",
"38437507",
"10426993",
"36631610",
"19471115",
"25949914",
"27307596",
"20532954",
"19211933",
"15661891",
"18594005",
"19454726",
"22467661",
"19171897",
"15611247",
"22009762",
"29310916",
"22250090",
"32435249",
"35613579",
"21898417",
"29758330",
"16547270",
"28346400",
"35783107",
"21496392",
"37474835",
"37531161",
"36928415",
"29147601",
"33101298",
"35693762",
"30967876",
"38172341",
"27744240",
"37596653",
"32965927",
"30594069",
"35105688",
"32998970",
"38266761",
"33824268",
"28919985",
"31783889",
"27392648",
"32714329",
"28818060",
"37134157",
"38809963",
"36162920",
"37387794",
"29899740",
"38012415",
"36868236",
"38804118",
"36647169",
"21268005",
"38324004"
] | [] | 10.242367 | 4.348849 |
39715901 | 98 | Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors. | Resistance to chimaeric antigen receptor (CAR) T cell therapy develops through multiple mechanisms, most notably antigen loss and tumour-induced immune suppression. It has been suggested that T cells expressing multiple CARs may overcome the resistance of tumours and that T cells expressing receptors that switch inhibitory immune-checkpoint signals into costimulatory signals may enhance the activity of the T cells in the tumour microenvironment. However, engineering multiple features into a single T cell product is difficult because of the transgene-packaging constraints of current gene-delivery vectors. Here we describe a cell-sorting method that leverages leucine zippers for the selective single-step immunomagnetic purification of cells co-transduced with two vectors. Such 'Zip sorting' facilitated the generation of T cells simultaneously expressing up to four CARs and coexpressing up to three 'switch' receptors. In syngeneic mouse models, T cells with multiple CARs and multiple switch receptors eliminated antigenically heterogeneous populations of leukaemia cells coexpressing multiple inhibitory ligands. By combining diverse therapeutic strategies, Zip-sorted multi-CAR multi-switch-receptor T cells can overcome multiple mechanisms of CAR T cell resistance. | [
0.02374090813100338,
0.008248014375567436,
0.05553168058395386,
0.029474887996912003,
-0.047580890357494354,
-0.03106009215116501,
-0.003966106101870537,
0.01810600236058235,
-0.012743554078042507,
-0.028013527393341064,
0.006201491691172123,
-0.006538966670632362,
-0.025053653866052628,
0.029499655589461327,
-0.010303826071321964,
-0.05250988528132439,
0.05899931117892265,
0.026601705700159073,
0.009585530497133732,
0.03963010013103485,
-0.016372185200452805,
0.013251314871013165,
0.023307453840970993,
-0.0044212331995368,
-0.02006273902952671,
-0.00804367195814848,
0.048497337847948074,
0.031456392258405685,
-0.0077526383101940155,
-0.023146456107497215,
0.03638538718223572,
-0.022502467036247253,
0.016941867768764496,
0.017722085118293762,
-0.03675691783428192,
0.008142746984958649,
0.011895222589373589,
-0.007597833406180143,
-0.01925775222480297,
-0.019827434793114662,
0.06558781862258911,
0.04829918593168259,
0.0003417322295717895,
0.046045225113630295,
-0.025326112285256386,
0.03395804390311241,
-0.04081900417804718,
-0.028731822967529297,
-0.020669573917984962,
0.017623011022806168,
-0.0003417322295717895,
-0.009183037094771862,
-0.05622520670294762,
0.02301022782921791,
-0.054392315447330475,
0.034255269914865494,
-0.04777904227375984,
-0.004226178862154484,
-0.024038132280111313,
0.026477862149477005,
0.00804367195814848,
-0.004402656573802233,
0.03148116171360016,
-0.0244715865701437,
-0.033066365867853165,
0.015492892824113369,
-0.022700617089867592,
-0.022613925859332085,
0.015715811401605606,
0.05414462462067604,
-0.003997066989541054,
-0.015307126566767693,
0.026948468759655952,
-0.0008932253113016486,
0.05939561501145363,
-0.0014985131565481424,
-0.013003626838326454,
0.02734476886689663,
0.028459366410970688,
-0.0036533998791128397,
0.015294741839170456,
0.0018607571255415678,
0.03338836133480072,
-0.07247354835271835,
-0.012489673681557178,
-0.03943195194005966,
0.03512217849493027,
-0.011077851988375187,
-0.05364925041794777,
-0.02707231231033802,
0.0011424615513533354,
0.004922801628708839,
-0.04163637384772301,
0.04490585997700691,
-0.013697153888642788,
0.021053491160273552,
0.02097918465733528,
-0.05092468112707138,
0.0257347971200943,
0.05142005532979965,
0.025326112285256386,
-0.013350389897823334,
-0.0026239461731165648,
-0.0015379885444417596,
0.02055811509490013,
-0.010984968394041061,
-0.04166114330291748,
-0.010130444541573524,
-0.002301951637491584,
0.003950625658035278,
0.08678992092609406,
-0.016372185200452805,
0.013858150690793991,
0.06479521840810776,
-0.0033468857873231173,
-0.08109309524297714,
-0.01619880460202694,
0.0022013282869011164,
0.016979021951556206,
0.014886057004332542,
-0.010563898831605911,
-0.001984601141884923,
0.04024932160973549,
-0.014068685472011566,
-0.031233472749590874,
-0.04720935598015785,
0.05122190713882446,
-0.04876979440450668,
-0.032224226742982864,
-0.027963990345597267,
0.02959873154759407,
0.008489510975778103,
0.03918426111340523,
0.007498758379369974,
-0.04914132505655289,
-0.020657191053032875,
-0.0022787307389080524,
0.009282113052904606,
-0.0565224327147007,
0.017932619899511337,
0.030044570565223694,
0.0020078218076378107,
-0.022985458374023438,
0.004876360297203064,
-0.012254370376467705,
-0.035592783242464066,
-0.012855013832449913,
0.0037741479463875294,
-0.029053818434476852,
0.064943827688694,
-0.025251805782318115,
0.04111623018980026,
0.041834525763988495,
0.0005631034728139639,
-0.008687661029398441,
-0.0341561920940876,
-0.013870535418391228,
0.07405874878168106,
-0.023109301924705505,
-0.0489431731402874,
-0.026354016736149788,
-0.003223041770979762,
-0.03388373553752899,
-0.03532032668590546,
0.016248341649770737,
0.001480710576288402,
-0.00038140101241879165,
0.048571642488241196,
-0.06449799239635468,
-0.02271300181746483,
-0.04069516062736511,
-0.047927651554346085,
-0.06271463632583618,
-0.025710027664899826,
-0.027592457830905914,
-0.015381433069705963,
-0.03301682695746422,
0.025189882144331932,
-0.0147622125223279,
-0.03613770008087158,
-0.007876482792198658,
0.01424206793308258,
0.007795983925461769,
0.02006273902952671,
-0.033982813358306885,
-0.01680563949048519,
-0.021808939054608345,
-0.0016657026717439294,
-0.015443354845046997,
-0.016285493969917297,
-0.0058702086098492146,
0.01508420705795288,
0.033561740070581436,
0.01108404342085123,
0.01261971052736044,
-0.030837172642350197,
0.028087833896279335,
0.03943195194005966,
-0.01761062629520893,
-0.058256249874830246,
-0.01811838708817959,
0.00918922945857048,
-0.002537255408242345,
-0.007362529635429382,
-0.033338822424411774,
-0.013251314871013165,
-0.05191543325781822,
0.01131315529346466,
-0.012372022494673729,
0.02271300181746483,
0.04564892128109932,
0.024174362421035767,
-0.01188903022557497,
0.0017214325489476323,
-0.03863934800028801,
-0.04817534238100052,
0.003916568588465452,
0.01891098916530609,
-0.03338836133480072,
0.03915949538350105,
-0.01601303741335869,
-0.02121448889374733,
-0.011183119378983974,
0.005913554225116968,
-0.05865254998207092,
-0.001099890097975731,
0.024706890806555748,
-0.02465735375881195,
-0.003421192290261388,
-0.007734061684459448,
-0.013647615909576416,
0.04441048204898834,
0.04242897778749466,
-0.04817534238100052,
-0.006402738392353058,
-0.010000408627092838,
0.038391660898923874,
-0.032992057502269745,
0.04208221286535263,
-0.043865568935871124,
-0.0094988401979208,
0.02229193225502968,
0.04067039117217064,
-0.009783681482076645,
-0.027889683842658997,
0.0028190005104988813,
-0.03423050045967102,
-0.07128464430570602,
0.0017446533311158419,
-0.03541940450668335,
0.025908177718520164,
0.03269483149051666,
0.00957314670085907,
0.022192856296896935,
0.014316374436020851,
0.04606999084353447,
0.07366245239973068,
0.010006600059568882,
0.034676339477300644,
-0.005040453281253576,
-0.01749916560947895,
0.018477534875273705,
-0.03955579549074173,
-0.00237935408949852,
-0.0514695942401886,
0.022576773539185524,
-0.0007856357842683792,
0.02048380859196186,
-0.0004899580962955952,
-0.017734469845891,
0.0162359569221735,
0.019691206514835358,
0.019158676266670227,
-0.005049741826951504,
-0.06677672266960144,
0.0074863736517727375,
0.02600725367665291,
0.06256601959466934,
-0.019047217443585396,
0.026205403730273247,
-0.03170407935976982,
0.009857987985014915,
0.008600970730185509,
0.003535747993737459,
0.0017136922106146812,
-0.015951115638017654,
-0.02308453433215618,
-0.02205662801861763,
0.007616410031914711,
-0.07465320080518723,
0.03029225766658783,
-0.02608156017959118,
-0.02469450607895851,
0.011034506373107433,
-0.05310433357954025,
0.014390680007636547,
-0.01665702648460865,
-0.021734634414315224,
-0.04522785171866417,
0.023604677990078926,
-0.034255269914865494,
0.013622847385704517,
-0.010353364050388336,
-0.03997686505317688,
0.0008413656032644212,
0.005433658603578806,
-0.04396464303135872,
-0.0467882864177227,
0.02595771662890911,
0.04735796898603439,
0.008371858857572079,
-0.03638538718223572,
-0.018403228372335434,
0.020421886816620827,
-0.011523690074682236,
-0.029895957559347153,
0.006508005782961845,
-0.058305785059928894,
0.031159166246652603,
-0.06593458354473114,
-0.032372839748859406,
0.023864751681685448,
-0.04158683866262436,
-0.008501894772052765,
0.0363110788166523,
-0.0009806902380660176,
-0.008433780632913113,
-0.018403228372335434,
-0.0017725181533023715,
-0.017784006893634796,
0.037698134779930115,
-0.035468939691782,
0.03673214837908745,
-0.000500407419167459,
-0.022242393344640732,
-0.030961016193032265,
-0.06895637512207031,
-0.011288386769592762,
0.028508903458714485,
0.01960451528429985,
-0.0029351043049246073,
0.05919746309518814,
-0.03150593116879463,
0.0363110788166523,
0.0320013053715229,
-0.011610381305217743,
0.014118223451077938,
0.03262052685022354,
-0.007374913897365332,
0.011771378107368946,
0.03413142263889313,
0.028038296848535538,
0.022812077775597572,
0.0023638736456632614,
0.013598078861832619,
0.010229519568383694,
-0.02890520542860031,
0.027666764333844185,
0.0039010881446301937,
0.007009574212133884,
0.042329899966716766,
0.041140999644994736,
-0.04760565981268883,
0.03963010013103485,
0.027369538322091103,
0.06608319282531738,
-0.01960451528429985,
0.01972835883498192,
-0.007622602395713329,
-0.028360290452837944,
-0.0043407343327999115,
-0.02937581203877926,
0.03309113532304764,
0.02037234790623188,
0.013746690936386585,
0.03774766996502876,
-0.0042788125574588776,
0.04121530428528786,
0.035444170236587524,
-0.023839982226490974,
0.04079423472285271,
-0.016174035146832466,
-0.0183413065969944,
-0.045475542545318604,
-0.009802257642149925,
-0.0011649082880467176,
0.023827597498893738,
-0.013238931074738503,
-0.040918078273534775,
0.008892003446817398,
-0.023654216900467873,
-0.03380943089723587,
0.02979688160121441,
-0.01194476056843996,
-0.024558277800679207,
0.058454398065805435,
-0.023381760343909264,
0.06122850626707077,
0.03301682695746422,
0.02588341012597084,
-0.0075111426413059235,
-0.04285004734992981,
-0.030812403187155724,
-0.049488089978694916,
0.015022285282611847,
-0.027022775262594223,
0.0523117333650589,
0.0077216774225234985,
0.04319680854678154,
-0.002949036890640855,
0.016557952389121056,
-0.013325621373951435,
0.03296729177236557,
0.037351369857788086,
-0.015790117904543877,
-0.01922059990465641,
-0.026527399197220802,
0.04124007374048233,
0.006096224300563335,
0.01525758858770132,
0.019307289272546768,
-0.011635149829089642,
0.005018780939280987,
-0.009127307683229446,
0.02684939280152321,
0.018019311130046844,
0.009554569609463215,
0.025833871215581894,
0.015133745037019253,
-0.02331983670592308,
-0.010780625976622105,
0.03816873952746391,
0.01650841347873211,
-0.03675691783428192,
-0.021152567118406296,
0.04180975630879402,
-0.015579583123326302,
0.0011277550365775824,
-0.033140670508146286,
0.01304078008979559,
-0.01009329129010439,
0.0366826131939888,
0.023790445178747177,
0.004990915767848492,
0.0358404740691185,
0.003223041770979762,
-0.008817697875201702,
0.0031580235809087753,
-0.037772439420223236,
-0.019133908674120903,
-0.026552166789770126,
0.015381433069705963,
-0.028137370944023132,
0.04215652123093605,
-0.029276737943291664,
-0.02515272982418537,
0.04805149883031845,
-0.03319020941853523,
0.004733939189463854,
0.005439850501716137,
0.003052756190299988,
-0.0447324775159359,
0.0040682777762413025,
-0.017338169738650322,
0.00033495950629003346,
0.03767336532473564,
0.040645621716976166,
-0.027518151327967644,
0.015517661347985268,
-0.02623017318546772,
-0.008861042559146881,
-0.003498594742268324,
-0.03319020941853523,
0.03710368275642395,
-0.02033519558608532,
0.02883089892566204,
0.024261051788926125,
0.0147622125223279,
-0.007833137176930904,
0.004879456013441086,
-0.0375247523188591,
-0.04059608653187752,
-0.030961016193032265,
0.0028623458929359913,
0.030341796576976776,
0.04507923871278763,
0.007282031234353781,
0.015331895090639591,
-0.008625739254057407,
-0.00928830448538065,
0.021387869492173195,
-0.015802502632141113,
0.013399927876889706,
-0.011752801947295666,
-0.00819228496402502,
-0.047655194997787476,
0.012142910622060299,
-0.026180636137723923,
-0.022638695314526558,
0.005600847769528627,
0.020000817254185677,
0.02714661881327629,
-0.00123302242718637,
0.024422049522399902,
0.03113439865410328,
0.045698460191488266,
0.02009989134967327,
0.02600725367665291,
0.006799039430916309,
0.021053491160273552,
0.0035388441756367683,
-0.043791260570287704,
0.017548704519867897,
-0.02642832323908806,
-0.044782012701034546,
-0.015294741839170456,
-0.015876809135079384,
-0.042106982320547104,
-0.008978694677352905,
-0.023344606161117554,
-0.0168427936732769,
-0.0371532179415226,
-0.023604677990078926,
0.04483155161142349,
0.023765675723552704,
-0.01806885004043579,
-0.01311508659273386,
-0.024942195042967796,
-0.048001959919929504,
-0.035394635051488876,
0.011666110716760159,
0.0015101236058399081,
0.001178066711872816,
0.044212330132722855,
-0.01680563949048519,
-0.004130199551582336,
0.008285167627036572,
0.035394635051488876,
-0.0017709701787680387,
-0.04502970352768898,
0.008873427286744118,
-0.0033159248996526003,
0.013697153888642788,
-0.00027574654086492956,
-0.011517497710883617,
0.021647943183779716,
0.0032137534581124783,
-0.03428003564476967,
0.017969774082303047,
-0.0067495014518499374,
0.004647248424589634,
-0.03093624673783779,
0.029202431440353394,
-0.01223579328507185,
0.007876482792198658,
-0.039729177951812744,
-0.004213794134557247,
-0.014130608178675175,
-0.009461686946451664,
-0.032149918377399445,
-0.036781687289476395,
-0.009257343597710133,
0.019579747691750526,
-0.030465640127658844,
-0.020706728100776672,
-0.002289567142724991,
-0.01370953768491745,
0.00005418177897809073,
-0.023542756214737892,
0.04017501324415207,
-0.026601705700159073,
-0.002224548952654004,
0.015591967850923538,
-0.040645621716976166,
0.03316543996334076,
0.024979347363114357,
-0.01139365416020155,
-0.0227873083204031,
-0.008285167627036572,
0.007994133979082108,
-0.03029225766658783,
-0.026279710233211517,
0.025511877611279488,
0.020892493426799774,
-0.03504787012934685,
0.025053653866052628,
-0.044782012701034546,
-0.01826700009405613,
-0.04242897778749466,
0.009505031630396843,
0.043320655822753906,
0.012588749639689922,
0.03725229576230049,
0.0062819900922477245,
-0.04131438210606575,
0.0295244250446558,
-0.010006600059568882,
0.023183608427643776,
-0.03423050045967102,
-0.010495784692466259,
0.017635395750403404,
-0.007913636043667793,
-0.031035322695970535,
-0.047035977244377136,
-0.0316297747194767,
0.038193508982658386,
-0.010025177150964737,
0.015530046075582504,
-0.004207602236419916,
0.006935267709195614,
0.03564232215285301,
0.031307779252529144,
-0.02623017318546772,
0.024558277800679207,
0.02029804326593876,
0.013139855116605759,
-0.0286822859197855,
-0.016681795939803123,
0.011554650962352753,
-0.019406365230679512,
-0.01116454228758812,
-0.016991406679153442,
-0.026626473292708397,
-0.00517048966139555,
0.0031642159447073936,
-0.03338836133480072,
0.00096443563234061,
-0.004978531505912542,
0.02972257509827614,
0.006699963938444853,
-0.024112438783049583,
-0.041487760841846466,
0.0007217787206172943,
0.03963010013103485,
0.005374832544475794,
-0.0032478105276823044,
0.026180636137723923,
0.010136636905372143,
0.01416776143014431,
0.004857783671468496,
0.011616573669016361,
0.007709293160587549,
0.013003626838326454,
-0.02538803406059742,
0.02630447968840599,
-0.01949305646121502,
-0.011597996577620506,
0.02860797941684723,
0.040645621716976166,
-0.0008924513240344822,
0.010136636905372143,
-0.029895957559347153,
0.02917766198515892,
-0.003162667853757739,
0.014353526756167412,
-0.011207887902855873,
0.027617227286100388,
-0.019096754491329193,
0.05250988528132439,
0.044707708060741425,
-0.024186745285987854,
0.024942195042967796,
-0.01543097011744976,
-0.032917752861976624,
0.010056138038635254,
0.0021533386316150427,
0.009635068476200104,
-0.008501894772052765,
0.004560557659715414,
0.006792847067117691,
0.046243373304605484,
0.023257914930582047,
-0.013437081128358841,
0.020347580313682556,
-0.04609476029872894,
0.015121360309422016,
0.007077688351273537,
-0.0010248096659779549,
-0.03943195194005966,
-0.0017462013056501746,
0.00012355380749795586,
0.020434271544218063,
-0.02883089892566204,
-0.035468939691782,
-0.017635395750403404,
-0.013399927876889706,
-0.005712307523936033,
-0.013598078861832619,
0.004554365295916796,
-0.01585203967988491,
-0.004851591307669878,
0.0001639966358197853,
-0.01091066189110279,
-0.010217135772109032,
0.03591477870941162,
-0.01409345492720604,
0.007288223132491112,
-0.01409345492720604,
0.005557502619922161,
0.01879952847957611,
0.04200790822505951,
0.0029598730616271496,
0.024867888540029526,
0.013560925610363483,
0.02855844236910343,
-0.02167271077632904,
0.010947815142571926,
0.0038205895107239485,
-0.01071870420128107,
0.025982484221458435,
0.0002041491970885545,
-0.014898440800607204,
-0.005052838008850813,
-0.03851550444960594,
0.0021703671663999557,
0.006173626519739628,
-0.004297389183193445,
0.020013200119137764,
0.00959172286093235,
0.0010101031512022018,
0.0029645173344761133,
0.01808123290538788,
-0.021078260615468025,
0.014192529954016209,
0.031530700623989105,
0.003179696388542652,
-0.05082560330629349,
0.043593112379312515,
-0.04701120778918266,
0.006972420960664749,
-0.0055451178923249245,
-0.03710368275642395,
-0.021895630285143852,
-0.004281908739358187,
-0.016607489436864853,
0.04971100762486458,
-0.012019066140055656,
-0.030317027121782303,
-0.029152892529964447,
-0.02665124274790287,
0.016718948259949684,
-0.04480678215622902,
-0.014811750501394272,
0.043741725385189056,
-0.02665124274790287,
0.023517988622188568,
0.02121448889374733,
0.01726386323571205,
-0.0007987942080944777,
0.0031440912280231714,
-0.007758830673992634,
0.009622683748602867,
-0.017437243834137917,
0.012173871509730816,
-0.0358404740691185,
-0.04069516062736511,
-0.0009590174886398017,
0.014972747303545475,
0.018948141485452652,
-0.0074863736517727375,
-0.014081070199608803,
0.03554324805736542,
0.00993848592042923,
0.007158187218010426,
-0.0040125478990375996,
-0.011820916086435318,
-0.0038948957808315754,
0.014786981046199799,
-0.03556801378726959,
0.06281370669603348,
-0.017474398016929626,
-0.00002960647179861553,
0.004839207045733929,
0.019282521679997444,
-0.011368885636329651,
0.01638456992805004,
-0.006266509648412466,
0.011176927015185356,
0.011430807411670685,
-0.01363523118197918,
-0.004641056526452303,
0.015344279818236828,
-0.0312582403421402,
-0.0030419197864830494,
-0.030837172642350197,
-0.003365462413057685,
-0.024000979959964752,
0.017338169738650322,
-0.013573309406638145,
-0.012916935607790947,
-0.023542756214737892,
0.03695506975054741,
-0.022242393344640732,
0.008638123981654644,
-0.03113439865410328,
0.03579093515872955,
0.013622847385704517,
-0.10184936225414276,
-0.013672384433448315,
-0.015505276620388031,
-0.0121181420981884,
-0.00508379889652133,
0.008328513242304325,
0.010031369514763355,
-0.027790607884526253,
-0.027245694771409035,
-0.0395805649459362,
-0.01139365416020155,
-0.004709170665591955,
0.02328268438577652,
0.012211024761199951,
0.013759075663983822,
-0.016186419874429703,
-0.002362325554713607,
-0.04307296499609947,
0.004086853936314583,
0.015282358042895794,
-0.014081070199608803,
-0.006904306821525097,
-0.03616246581077576,
0.015307126566767693,
-0.008501894772052765,
0.009672221727669239,
-0.015554814599454403,
-0.01164134219288826,
-0.06608319282531738,
-0.004737035371363163,
0.016025422140955925,
-0.01424206793308258,
-0.01198810525238514,
0.04339496046304703,
-0.025264188647270203,
-0.03430480509996414,
0.03997686505317688,
-0.0197902824729681,
-0.007647370919585228,
0.017090480774641037,
0.0038484544493258,
0.018167924135923386,
-0.004566750023514032,
-0.014960363507270813,
-0.026403555646538734,
-0.0017632298404350877,
-0.05657196789979935,
-0.010229519568383694,
0.02469450607895851,
-0.03239760920405388,
0.015876809135079384,
-0.014390680007636547,
-0.006619465537369251,
-0.007473989389836788,
0.0003676620835904032,
-0.0250784233212471,
-0.006052878685295582,
0.04584707319736481,
-0.009789873845875263,
0.00443361746147275,
-0.047308433800935745,
0.04423709958791733,
0.038391660898923874,
-0.025090808048844337,
0.0015085755148902535,
-0.010508169420063496,
-0.024521125480532646,
0.005328390747308731,
-0.04361787810921669,
-0.009901332668960094,
0.0015232820296660066,
0.002718377159908414,
-0.03477541357278824,
0.027121851220726967,
-0.02469450607895851,
-0.013548540882766247,
-0.013065548613667488,
0.005579174961894751,
-0.012421559542417526,
0.022651080042123795,
0.003554324619472027,
-0.03071332909166813,
-0.021610789000988007,
-0.025982484221458435,
-0.01510897558182478,
0.010842547751963139,
-0.0066628106869757175,
0.011926183477044106,
0.03863934800028801,
0.014749827794730663,
-0.0059259384870529175,
0.009566954337060452,
-0.007300607860088348,
0.001749297371134162,
-0.002130117965862155,
0.006836192216724157,
-0.03326451778411865,
-0.011176927015185356,
-0.013127471320331097,
0.010984968394041061,
0.0506274551153183,
-0.016396954655647278,
-0.00025968553381972015,
-0.04602045565843582,
-0.056423354893922806,
0.0011966433376073837,
0.07143325358629227,
-0.0008792928420007229,
0.01510897558182478,
0.008557625114917755,
0.023939058184623718,
-0.027394307777285576,
-0.012508250772953033,
-0.007263454608619213,
0.00443361746147275,
0.007560680154711008,
0.045970916748046875,
-0.0206819586455822,
0.017325785011053085,
0.01592634618282318,
0.05280711129307747,
0.005969284102320671,
-0.00631914334371686,
-0.037277065217494965,
0.0044552902691066265,
-0.0014892248436808586,
0.026131097227334976,
0.04621860384941101,
0.021152567118406296,
0.011418422684073448,
0.004359310958534479,
-0.01409345492720604,
0.02132594771683216,
-0.007424451876431704,
-0.005969284102320671,
0.04753135144710541,
0.005229315720498562,
0.029227199032902718,
-0.022465312853455544,
0.04572322964668274,
0.00483301468193531,
-0.01907198689877987,
-0.005189066287130117,
-0.03527079150080681,
0.013251314871013165,
-0.019393980503082275,
-0.01731340028345585,
0.0358404740691185,
-0.006743309553712606,
0.008861042559146881,
-0.031530700623989105,
0.028211677446961403,
0.01925775222480297,
0.050875142216682434,
0.013201777823269367,
0.05364925041794777,
0.05065222457051277,
-0.026279710233211517,
-0.007833137176930904,
0.021090643480420113,
-0.030490409582853317,
0.04297389090061188,
-0.0085390480235219,
-0.010049945674836636,
-0.0162359569221735,
0.0022725386079400778,
0.007647370919585228,
-0.027047544717788696,
0.028806129470467567,
0.03120870515704155,
0.0038948957808315754,
-0.06875822693109512,
0.02714661881327629,
-0.02764199487864971,
-0.024867888540029526,
0.0019242272246629,
0.05468953773379326,
0.0064584678038954735,
0.0212887953966856,
0.026329249143600464,
-0.022428160533308983,
0.00468130549415946,
-0.0006617917097173631,
0.03598908707499504,
0.006489429157227278,
-0.00943691749125719,
0.0036533998791128397,
-0.03437911346554756,
0.027716301381587982,
0.008130363188683987,
-0.01510897558182478,
-0.03457726165652275,
0.006124089006334543,
0.06103035435080528,
0.031530700623989105,
0.01696663722395897,
-0.0191834457218647,
0.0041890256106853485,
-0.015653889626264572,
-0.032917752861976624,
-0.029128124937415123,
0.027617227286100388,
0.01041528582572937,
-0.018886219710111618,
-0.04398941248655319,
0.005446042865514755,
0.020842956379055977,
-0.023517988622188568,
-0.015307126566767693,
0.04250328242778778,
0.017635395750403404,
0.02021135203540325,
0.010904469527304173,
0.02527657337486744,
0.007337761111557484,
0.02247769758105278,
-0.009734143503010273,
-0.02531372755765915,
-0.027691533789038658,
0.007083880715072155,
-0.01441544946283102,
-0.02910335548222065,
-0.00006153502181405202,
-0.01009329129010439,
-0.018093617632985115,
-0.023839982226490974,
0.022651080042123795,
0.0016858273884281516,
-0.00647085253149271,
0.00565657764673233,
-0.010266672819852829,
0.03351220488548279,
0.010118059813976288,
0.019480671733617783,
0.016112113371491432,
-0.02833552286028862,
-0.017164787277579308,
-0.019022447988390923,
0.01784593053162098,
-0.008371858857572079,
0.03913472592830658,
0.024496356025338173,
-0.002918075770139694,
0.0018375363433733582,
-0.006619465537369251,
-0.007876482792198658,
0.03569186106324196,
-0.04441048204898834,
-0.0006633398006670177,
0.004709170665591955,
0.0019133908208459616,
-0.001262435456737876,
0.015294741839170456,
0.03824304789304733,
0.03158023580908775,
-0.006916691083461046,
0.004950666334480047,
0.009696990251541138,
0.017982158809900284,
0.01083635538816452,
0.006238644942641258,
-0.02707231231033802,
0.038317352533340454,
0.007034342736005783,
0.03232330083847046,
-0.013981995172798634,
0.010074715130031109,
-0.011096428148448467,
-0.010811586864292622,
0.0017400091746822,
0.022688232362270355,
0.031456392258405685,
-0.010724895633757114,
0.029400581493973732,
0.018366074189543724,
0.006408930290490389,
0.005929034668952227,
0.021660327911376953,
-0.02561095356941223,
-0.003792724572122097,
-0.004687497857958078,
-0.0029459407087415457,
-0.030267490074038506,
-0.00409614248201251,
0.021202104166150093,
-0.005730884149670601,
-0.003579093609005213,
-0.007498758379369974,
0.008235630579292774,
-0.019703591242432594,
0.0011741966009140015,
-0.013152239844202995,
-0.013375159353017807,
-0.019208215177059174,
-0.014502139762043953,
-0.0033747507259249687,
0.0009032876696437597,
-0.02855844236910343,
-0.00435621477663517,
-0.02286161482334137,
-0.00003364591611898504,
0.023864751681685448,
-0.010960199870169163,
-0.037698134779930115,
0.03806966543197632,
-0.004449097905308008,
-0.03143162280321121,
-0.03158023580908775,
0.056076593697071075,
-0.02848413586616516,
-0.040719930082559586,
0.01865091547369957,
0.028929973021149635,
-0.014638368971645832,
0.06301186233758926,
0.01654556766152382,
-0.018514687195420265,
0.003823685459792614,
0.010687743313610554,
0.027716301381587982,
-0.012817860580980778,
0.027295231819152832,
0.014130608178675175,
-0.006526582408696413,
-0.02615586668252945,
-0.008700045756995678,
-0.003188984701409936,
-0.02615586668252945,
-0.012892167083919048,
0.009969447739422321,
0.011195503175258636,
-0.007672139909118414,
-0.0060590710490942,
-0.013226546347141266,
0.004192121792584658,
0.002678127959370613,
0.01806885004043579,
-0.017821161076426506,
-0.009325457736849785,
-0.012477289885282516,
0.006371777039021254,
-0.008316129446029663,
0.02531372755765915,
0.005675154272466898,
0.005721595603972673,
0.010539130307734013,
0.009183037094771862,
0.00712103396654129,
-0.03970440849661827,
-0.022007090970873833,
0.04824964702129364,
-0.022118549793958664,
-0.02143740840256214,
0.05533352866768837,
0.023072149604558945,
-0.005080702714622021,
-0.006105512380599976,
0.028657516464591026,
-0.00738110626116395,
-0.020421886816620827,
-0.007473989389836788,
0.05166774243116379,
0.015604352578520775,
-0.01318939309567213,
-0.012663056142628193,
0.014440217986702919,
-0.05444185063242912,
-0.02209378220140934,
0.006656618323177099,
0.006799039430916309,
0.016979021951556206,
0.022688232362270355,
-0.0021703671663999557,
-0.0037865322083234787,
0.020669573917984962,
0.0020945128053426743,
0.03898611292243004,
0.026700779795646667,
0.020037969574332237,
0.0320013053715229,
0.0041642566211521626,
-0.030193183571100235,
-0.0018654012819752097,
-0.0362120047211647,
-0.014539293013513088,
-0.00809940230101347,
-0.026279710233211517,
-0.04366741701960564,
0.02106587588787079,
-0.0077774072997272015,
-0.01822984591126442,
-0.02209378220140934,
0.013486619107425213,
0.019171060994267464,
-0.03529555723071098,
-0.00015248300042003393,
-0.007802176289260387,
0.02209378220140934,
-0.006139569450169802,
0.005111663602292538,
-0.03856504335999489,
-0.0030744289979338646,
0.011170734651386738,
-0.012805476784706116,
-0.0059507074765861034,
0.033636048436164856,
0.012223409488797188,
-0.000060857746575493366,
0.0046317679807543755,
-0.006210779771208763,
-0.019505441188812256,
0.007300607860088348,
-0.04733320325613022,
0.013957226648926735,
-0.025982484221458435,
0.006297470536082983,
0.007734061684459448,
-0.0022725386079400778,
-0.014155376702547073,
-0.015864424407482147,
-0.012248178012669086,
-0.004551269579678774,
0.002738501876592636,
-0.001420336659066379,
-0.001993889454752207,
0.0019784090109169483,
0.022378623485565186,
0.0033159248996526003,
-0.05132098123431206,
-0.0008978694677352905,
0.02523942105472088,
0.0025945331435650587,
-0.004124007187783718,
-0.00516120158135891,
-0.04084377363324165,
0.01784593053162098,
-0.029648268595337868,
0.03995209559798241,
-0.033338822424411774,
0.017474398016929626,
0.011152158491313457,
-0.02972257509827614,
0.050033003091812134,
0.017053328454494476,
0.023022612556815147,
-0.04480678215622902,
0.00426952401176095,
0.0013615107163786888,
0.018638532608747482,
0.022638695314526558,
0.019270136952400208,
0.06558781862258911,
-0.023988595232367516,
-0.025932947173714638,
-0.017561089247465134,
0.00556988688185811,
-0.006774270441383123,
-0.02853367291390896,
0.008378051221370697,
0.020236119627952576,
-0.04319680854678154,
-0.0019041025079786777,
-0.0035419403575360775,
0.026824625208973885,
-0.017028558999300003,
0.019827434793114662,
-0.0077216774225234985,
-0.01907198689877987,
-0.009777489118278027,
-0.024038132280111313,
-0.002074388088658452,
-0.0015287002315744758,
0.019616900011897087,
0.005777325481176376,
0.009053001180291176,
-0.026180636137723923,
0.02553664706647396,
0.02917766198515892,
0.02301022782921791,
-0.03522125259041786,
-0.018849067389965057,
0.03133254870772362,
0.000722165685147047,
-0.005783517844974995,
0.005990956444293261,
0.0168923307210207,
-0.02603202313184738,
-0.039803482592105865,
0.03841643035411835,
0.006297470536082983,
-0.004619383718818426,
-0.016991406679153442,
-0.029276737943291664,
0.010359556414186954,
-0.027097081765532494,
-0.006189106963574886,
0.010018984787166119,
-0.018328921869397163,
0.002387094311416149,
0.0005762618966400623,
0.01612449809908867,
-0.02478119730949402,
0.019629284739494324,
-0.03901088237762451,
0.019319674000144005,
-0.012731170281767845,
-0.046961668878793716,
-0.057463645935058594,
0.02416197769343853,
0.022192856296896935,
-0.025288958102464676,
-0.005384120624512434,
-0.020966799929738045,
0.02650262974202633,
0.03487448766827583,
-0.024979347363114357,
-0.0019428037339821458,
0.03051517717540264,
0.02405051700770855,
-0.010799202136695385,
0.009467878378927708,
0.032570987939834595,
0.020285658538341522,
-0.006334623787552118,
-0.011077851988375187,
-0.028508903458714485,
0.017028558999300003,
0.009703182615339756,
-0.0069538443349301815,
0.02623017318546772,
0.03725229576230049,
-0.006241741124540567,
0.02083057165145874,
0.015591967850923538,
0.0033159248996526003,
0.050602685660123825,
-0.011771378107368946,
-0.024867888540029526,
-0.022651080042123795,
-0.0023607774637639523,
-0.02439728006720543,
0.01113977376371622,
0.03950625658035278,
-0.00867527723312378,
0.03641015663743019,
0.02623017318546772,
0.01131315529346466,
-0.013226546347141266,
0.007566872518509626,
0.04446002095937729,
0.02818690985441208,
-0.019777897745370865,
0.008012711070477962,
-0.026775086298584938,
-0.038391660898923874,
-0.05181635543704033,
0.0031951768323779106,
0.00655754329636693,
-0.003003218676894903,
-0.022391006350517273,
0.0539960116147995,
-0.02240339107811451,
0.019976047798991203,
0.008681468665599823,
0.0008777448092587292,
0.00016032000712584704,
0.002532611135393381,
-0.014749827794730663,
-0.031233472749590874,
-0.02236623875796795,
-0.003882511518895626,
-0.009455494582653046,
-0.015839656814932823,
0.0042447554878890514,
-0.013511387631297112,
0.013796228915452957,
0.002808164106681943,
-0.00681761559098959,
0.029078586027026176,
-0.0044800592586398125,
-0.028707053512334824,
0.027889683842658997,
-0.03281867876648903,
0.007622602395713329,
-0.021338332444429398,
-0.01995127834379673,
-0.05335202440619469,
0.006229356396943331,
-0.007213916629552841,
0.020421886816620827,
-0.050033003091812134,
0.0017910947790369391,
-0.015071822330355644,
-0.0027524344623088837,
0.03730183094739914,
0.009319266304373741,
-0.0027926836628466845,
-0.017325785011053085,
-0.008111786097288132,
0.011864261701703072,
-0.01746201328933239,
0.02037234790623188,
-0.002863893983885646,
-0.014712674543261528,
-0.02018658258020878,
-0.012142910622060299,
-0.015121360309422016,
-0.03185269236564636,
-0.019926510751247406,
0.007424451876431704,
-0.004990915767848492,
-0.0002409154112683609,
0.002815904328599572,
0.004297389183193445,
-0.0027152812108397484,
0.013313236646354198,
-0.04128961265087128,
0.027790607884526253,
0.014081070199608803,
-0.005062126088887453,
0.011591804213821888,
0.03182792663574219,
-0.033413127064704895,
-0.0007496436010114849,
0.02359229512512684,
0.0005263373022899032,
-0.007151994854211807,
-0.0019598323851823807,
0.021338332444429398,
-0.01806885004043579,
0.0034769221674650908,
0.012805476784706116,
0.005922842305153608,
-0.031084859743714333,
-0.018180308863520622,
-0.02531372755765915,
-0.02313407137989998,
0.012037643231451511,
-0.018167924135923386,
0.03276913985610008,
-0.013697153888642788,
0.006768078077584505,
0.00999421626329422,
0.021969936788082123,
-0.011449383571743965,
0.014365911483764648,
-0.0038763191550970078,
-0.024793582037091255,
0.0058051906526088715,
0.0054243700578808784,
0.003882511518895626,
0.025487108156085014,
0.0147622125223279,
0.008328513242304325,
0.02094203233718872,
0.025412801653146744,
-0.029499655589461327,
0.014081070199608803,
0.0019211310427635908,
-0.006170530337840319,
0.027320001274347305,
-0.01466313749551773,
0.0031100341584533453,
0.00689192209392786,
-0.013375159353017807,
0.0011153706582263112,
0.021759402006864548,
0.02776584029197693,
-0.025635721161961555,
-0.008210861124098301,
-0.0383668914437294,
-0.02083057165145874,
-0.020434271544218063,
0.0012376665836200118,
0.09466640651226044,
-0.055432602763175964,
-0.00859477836638689,
-0.0016951157012954354,
-0.0033530781511217356,
-0.038317352533340454,
0.02546234056353569,
0.018477534875273705,
0.03044087067246437,
-0.014786981046199799,
0.034403882920742035,
0.02022373676300049,
0.04507923871278763,
-0.000482217816170305,
0.020037969574332237,
-0.016223572194576263,
0.00027052187942899764,
0.03527079150080681,
-0.01074347272515297,
-0.017140017822384834,
0.00846474152058363,
0.004052796866744757,
-0.0038205895107239485,
0.020669573917984962,
-0.04530216008424759,
-0.02106587588787079,
-0.010780625976622105,
-0.026527399197220802,
0.0002834868209902197,
-0.018861452117562294,
0.016211187466979027,
0.018588993698358536,
0.025586184114217758,
-0.037475213408470154,
0.010885893367230892,
0.014254451729357243,
-0.019827434793114662,
-0.028880435973405838,
0.005473907571285963,
-0.015604352578520775,
0.0023731619585305452,
0.009405956603586674,
-0.0008274331921711564,
-0.011498921550810337,
0.02086772583425045,
0.0007682202267460525,
-0.001507027423940599,
0.008588586002588272,
0.009833218529820442,
-0.0014776145108044147,
0.01808123290538788,
0.010235711932182312,
0.03393327444791794,
-0.010712511837482452,
-0.016223572194576263,
0.0028948551043868065,
0.010619628243148327,
0.003548132488504052,
-0.006873345468193293,
-0.03219945728778839,
0.007430643774569035,
0.02707231231033802,
0.02201947569847107,
-0.005607040133327246,
0.014749827794730663
] | 2024-12-24 | 111 | 39715901 | [
"T cells",
"CAR T cell resistance",
"T cell therapy",
"cells",
"leukaemia cells",
"multiple switch receptors",
"multiple CARs",
"multiple mechanisms",
"multiple inhibitory ligands",
"multiple features",
"a single T cell product",
"Zip-sorted multi-CAR multi-switch-receptor T cells",
"antigen receptor",
"the T cells",
"receptors",
"CAR",
"diverse therapeutic strategies",
"costimulatory signals",
"tumours",
"leucine zippers",
"Zip",
"syngeneic mouse models",
"a cell-sorting method",
"Resistance",
"inhibitory immune-checkpoint signals",
"tumour-induced immune suppression",
"current gene-delivery vectors",
"the selective single-step immunomagnetic purification",
"Zip-sorted",
"Such Zip sorting"
] | [] | 0 | 10.1038/s41551-024-01287-3
10.1056/NEJMra1706169
10.1038/s41571-020-0427-6
10.1016/j.coi.2021.02.010
10.1158/2159-8290.CD-18-0442
10.1038/s41586-023-05707-3
10.1016/j.coi.2018.03.002
10.1158/1078-0432.CCR-19-1835
10.1016/j.ccell.2017.09.004
10.1038/s41586-019-1054-1
10.1172/JCI87366
10.1158/2326-6066.CIR-15-0231
10.1158/2159-8290.CD-22-0964
10.1038/s41591-021-01436-0
10.3324/haematol.2017.183459
10.1038/s41591-021-01497-1
10.1016/S1470-2045(23)00436-9
10.1038/s41586-019-0985-x
10.1073/pnas.1905675116
10.1158/2159-8290.CD-21-1586
10.1158/1535-7163.MCT-17-1097
10.1172/JCI83092
10.1182/blood-2017-04-777052
10.1172/JCI121491
10.1084/jem.20191166
10.1126/science.aba1786
10.1038/nature21405
10.1038/s41591-018-0290-5
10.1038/nm.3838
10.1177/1535676019899502
10.1126/science.ade0156
10.1038/s41591-022-02003-x
10.1038/s41586-023-05778-2
10.1126/scitranslmed.abd8836
10.1016/j.omto.2018.10.006
10.1158/2643-3230.BCD-20-0020
10.1172/JCI83416
10.1089/hum.2016.064
10.1172/JCI37630
10.1016/j.actbio.2020.05.004
10.1110/ps.39401
10.1016/j.cell.2018.03.038
10.1038/s41571-022-00704-3
10.1038/nm1676
10.1182/blood-2011-02-337360
10.1182/blood-2014-01-545020
10.1038/s41467-021-21078-7
10.1016/j.omtm.2016.11.002
10.1016/j.omtm.2016.11.003
10.1093/nar/gku769
10.1093/nar/gky1006
10.1182/blood-2004-11-4564
10.1182/blood-2009-08-232967
10.1089/hum.1998.9.14-2049
10.1084/jem.20050732
10.1038/s41591-018-0010-1
10.1038/s41590-020-0725-2
10.1158/0008-5472.CAN-16-0587
10.1038/s41586-019-1324-y
10.1172/JCI133215
10.1038/mt.2011.9
10.1172/jci.insight.96976
10.1158/2159-8290.CD-21-1026
10.1089/106161299320488
10.4049/jimmunol.1201610
10.1016/j.immuni.2016.04.019
10.1016/j.ccell.2015.09.004
10.1016/j.immuni.2016.01.021
10.1158/0008-5472.CAN-15-2524
10.1038/s41590-020-0620-x
10.4049/jimmunol.173.5.3002
10.4049/jimmunol.1401644
10.4049/jimmunol.176.10.5975
10.1016/j.celrep.2017.09.015
10.1038/s41586-022-04494-7
10.1016/j.immuni.2014.01.005
10.1038/s41590-023-01614-x
10.1038/s41586-022-04522-6
10.1016/j.cell.2016.08.052
10.1038/s41586-023-06568-6
10.1016/j.celrep.2022.111647
10.1038/s41467-023-35948-9
10.1016/j.cell.2018.11.043
10.1016/j.cell.2021.11.016
10.1016/j.freeradbiomed.2013.06.020
10.1038/s41586-018-0597-x
10.1126/scitranslmed.aaw9414
10.1158/1078-0432.CCR-19-1337
10.1038/s41586-018-0326-5
10.1038/leu.2015.62
10.1182/blood.V94.9.3135
10.1038/s41591-019-0549-5
10.1038/s41590-023-01571-5
10.1016/j.omtn.2023.04.017
10.1172/jci.insight.121322
10.1038/s43018-021-00244-2
10.1038/sj.gt.3302807
10.1089/104303403322167993
10.1182/blood.V96.2.459.014k50_459_466
10.1073/pnas.92.15.6733
10.1073/pnas.1008322108
10.1089/hgtb.2017.198
10.1371/journal.pcbi.0020157
10.1158/1078-0432.CCR-20-0832
10.1186/s13059-017-1382-0
10.1038/s41598-019-41695-z
10.1016/j.cels.2018.11.005
10.1038/s41592-018-0303-9
10.1016/j.cell.2018.05.061
10.1093/bioinformatics/btac757
10.1093/biomet/88.4.949
10.1093/nar/gku1003 | [
"James",
"Chen",
"Ng",
"Fischman",
"Jahn",
"Boardman",
"Rajagopalan",
"Elias",
"Massa",
"Manuele",
"Nichols",
"Lazrak",
"Lee",
"Roche",
"McFarland",
"Petrichenko",
"Everett",
"Bushman",
"Fei",
"Kousa",
"Lemarquis",
"DeWolf",
"Peled",
"Vardhana",
"Klebanoff",
"van den Brink"
] | [
"Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [email protected].\nWeill Cornell Medical College, New York, NY, USA. [email protected].\nDepartment of Immunology, Sloan Kettering Institute, New York, NY, USA. [email protected].\nCenter for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [email protected].\nParker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [email protected].\nCity of Hope National Medical Center, Duarte, CA, USA. [email protected].",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.\nCity of Hope National Medical Center, Duarte, CA, USA.",
"Weill Cornell Medical College, New York, NY, USA.\nDepartment of Immunology, Sloan Kettering Institute, New York, NY, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.\nImmunology Graduate Group, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.",
"Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.\nCity of Hope National Medical Center, Duarte, CA, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.\nHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.\nCity of Hope National Medical Center, Duarte, CA, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.",
"Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.\nCity of Hope National Medical Center, Duarte, CA, USA.",
"Department of Immunology, Sloan Kettering Institute, New York, NY, USA.\nCity of Hope National Medical Center, Duarte, CA, USA.",
"Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.\nWeill Cornell Medical College, New York, NY, USA.",
"Weill Cornell Medical College, New York, NY, USA.\nParker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.\nLymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.\nHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Weill Cornell Medical College, New York, NY, USA.\nCenter for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.\nParker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.\nHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.",
"Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [email protected].\nWeill Cornell Medical College, New York, NY, USA. [email protected].\nDepartment of Immunology, Sloan Kettering Institute, New York, NY, USA. [email protected].\nParker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [email protected].\nCity of Hope National Medical Center, Duarte, CA, USA. [email protected]."
] | [
"39715901",
"29972754",
"32978608",
"33752101",
"30135176",
"36813894",
"29554494",
"32015021",
"29017060",
"30918399",
"27571406",
"27059623",
"36416874",
"34312556",
"29419431",
"34642489",
"37863088",
"30814732",
"31152140",
"35554512",
"30181329",
"27454297",
"29042364",
"30694219",
"32860705",
"33795428",
"28225754",
"30559421",
"25939063",
"36033383",
"36520914",
"36175679",
"36890224",
"33910981",
"30581986",
"33089218",
"27427982",
"27611239",
"19307726",
"32442784",
"11344333",
"29706540",
"36418477",
"18026115",
"21653320",
"24970931",
"33542232",
"28344990",
"28344988",
"25147212",
"30357391",
"15728125",
"19880489",
"9759932",
"16203864",
"29713085",
"32661364",
"27742673",
"31207604",
"32069268",
"21326215",
"29321369",
"35904479",
"10349915",
"23203923",
"27192566",
"26461090",
"26885860",
"26979791",
"32152508",
"15322159",
"25404365",
"16670306",
"28978471",
"35296855",
"24530057",
"37709986",
"35322234",
"27610572",
"37731001",
"36384131",
"36658158",
"30595452",
"34861191",
"23792277",
"30305738",
"31554741",
"31439577",
"29995861",
"25748687",
"10556200",
"31477906",
"37500885",
"37200859",
"30232281",
"34746799",
"16763662",
"12908967",
"10887106",
"7624312",
"21205896",
"29378428",
"17166054",
"32816945",
"29409532",
"30914743",
"30954476",
"30664774",
"29961576",
"36426870",
"25352553"
] | [] | 8.66751 | 4.793289 |
39713739 | 99 | Titrating chimeric antigen receptors on CAR T cells enabled by a microfluidic-based dosage-controlled intracellular mRNA delivery platform. | Chimeric antigen receptor (CAR) T-cell therapy shows unprecedented efficacy for cancer treatment, particularly in treating patients with various blood cancers, most notably B-cell acute lymphoblastic leukemia. In recent years, CAR T-cell therapies have been investigated for treating other hematologic malignancies and solid tumors. Despite the remarkable success of CAR T-cell therapy, cytokine release syndrome (CRS) is an unexpected side effect that is potentially life-threatening. Our aim is to reduce pro-inflammatory cytokine release associated with CRS by controlling CAR surface density on CAR T cells. We show that CAR expression density can be titrated on the surface of primary T cells using an acoustic-electric microfluidic platform. The platform performs dosage-controlled delivery by uniformly mixing and shearing cells, delivering approximately the same amount of CAR gene coding mRNA into each T cell. | [
0.025999438017606735,
0.00597760546952486,
0.04152862727642059,
0.07163058966398239,
-0.05612656846642494,
-0.010967332869768143,
0.0236335638910532,
0.0003195266181137413,
-0.01673729531466961,
0.011099469847977161,
-0.00901674572378397,
-0.03128489851951599,
-0.060052912682294846,
0.013540849089622498,
0.010596091859042645,
-0.04875209182500839,
0.03171277046203613,
-0.01815933547914028,
0.020739145576953888,
0.009306187741458416,
0.0009721473907120526,
0.008211342617869377,
-0.012143976986408234,
0.022526133805513382,
0.010602383874356747,
-0.012093639932572842,
0.05934818461537361,
0.011992963962256908,
-0.025571566075086594,
-0.04308909550309181,
0.02357064187526703,
-0.02089015766978264,
-0.01872563548386097,
-0.05048874393105507,
-0.002910149982199073,
0.015818631276488304,
0.03349975869059563,
0.010287773795425892,
-0.0340283066034317,
-0.02990061230957508,
0.0186627134680748,
0.045480139553546906,
0.03040398843586445,
0.11346124112606049,
-0.061915408819913864,
0.0028928464744240046,
0.0053861369378864765,
-0.024338291957974434,
0.0200218316167593,
0.034128982573747635,
-0.030756352469325066,
0.022878497838974,
-0.021217353641986847,
0.024527058005332947,
-0.033675942569971085,
0.03667103499174118,
-0.03898657113313675,
0.035991474986076355,
0.01207476295530796,
-0.015050981193780899,
0.02110409364104271,
-0.020827235653996468,
0.017379101365804672,
-0.033675942569971085,
-0.049960196018218994,
-0.009526415728032589,
-0.05436474829912186,
-0.025873593986034393,
-0.0006532106781378388,
0.031108716502785683,
-0.006531320512294769,
-0.03667103499174118,
0.0064746905118227005,
0.00014088665193412453,
0.04084906727075577,
-0.020852403715252876,
-0.02477874793112278,
0.01320107001811266,
0.013087810017168522,
-0.0036903847940266132,
0.03803015500307083,
-0.019531039521098137,
-0.0064746905118227005,
-0.0460590235888958,
-0.03649485483765602,
-0.040723223239183426,
0.0038760052993893623,
-0.020814651623368263,
-0.030504664406180382,
0.009268434718251228,
-0.014547604136168957,
0.01574312523007393,
-0.04145311936736107,
0.039515119045972824,
-0.005310630425810814,
0.001131025841459632,
-0.007984822615981102,
-0.020940495654940605,
0.0427619032561779,
0.027232712134718895,
0.05340833216905594,
-0.002406772691756487,
-0.028113622218370438,
-0.013905798085033894,
0.03573978692293167,
0.02505560591816902,
-0.06246912106871605,
-0.01052058581262827,
0.02149420976638794,
-0.01800832338631153,
0.09528931975364685,
0.00889719370752573,
-0.009236973710358143,
0.04145311936736107,
-0.011432956904172897,
-0.05411306023597717,
0.0017099097603932023,
0.0009296749485656619,
-0.042283691465854645,
0.029950948432087898,
-0.017869893461465836,
0.03848319500684738,
0.026276294142007828,
-0.026754504069685936,
0.00919921975582838,
-0.0249926820397377,
0.0876379907131195,
-0.02447672188282013,
-0.04100007936358452,
-0.05673062056303024,
0.029095208272337914,
0.004898490384221077,
0.002255759434774518,
0.0073178475722670555,
-0.0629221647977829,
-0.01457277312874794,
0.004917366895824671,
-0.020575547590851784,
-0.02540796995162964,
-0.011344865895807743,
0.02823946624994278,
0.0030973434913903475,
-0.0005061301635578275,
-0.0018105852650478482,
-0.03694789484143257,
-0.04208234325051308,
-0.026452476158738136,
0.021393535658717155,
-0.0038665668107569218,
0.023897837847471237,
-0.025269540026783943,
0.06740222126245499,
0.038130830973386765,
0.01288645900785923,
0.008676965720951557,
-0.05245191603899002,
0.01712741330265999,
0.05235124006867409,
-0.010054961778223515,
-0.058995820581912994,
-0.00946978572756052,
0.009734058752655983,
-0.044599227607250214,
-0.0352364107966423,
0.02555898204445839,
-0.03805532306432724,
-0.010810027830302715,
0.025898762047290802,
-0.05657960847020149,
-0.011193852871656418,
-0.04804736375808716,
-0.053760696202516556,
-0.10299099236726761,
-0.018171921372413635,
-0.05642859637737274,
-0.012603309005498886,
0.009740350767970085,
0.028264636173844337,
-0.02341962791979313,
-0.02122993767261505,
0.02188432775437832,
0.03055500239133835,
-0.011665768921375275,
-0.0029368919786065817,
-0.025395384058356285,
0.02164522372186184,
-0.01562986522912979,
0.013289161026477814,
-0.026804840192198753,
-0.019417779520154,
-0.0024791331961750984,
0.0026411577127873898,
0.032291654497385025,
-0.0026600344572216272,
-0.0073807695880532265,
-0.013289161026477814,
0.016812801361083984,
0.027534738183021545,
-0.03795464709401131,
-0.03579012677073479,
0.03548809885978699,
-0.019493285566568375,
-0.048399727791547775,
-0.011590261943638325,
-0.02655315212905407,
-0.030605340376496315,
-0.024438967928290367,
0.045203279703855515,
-0.024589981883764267,
-0.0007165261195041239,
0.05006087198853493,
0.007582120597362518,
-0.02836531028151512,
0.016447853296995163,
-0.031209392473101616,
-0.0005010177264921367,
0.008148419670760632,
0.04386933147907257,
0.018146751448512077,
-0.0004046681569889188,
-0.028617000207304955,
-0.015969645231962204,
-0.0032074572518467903,
0.024728409945964813,
-0.05320698022842407,
0.016372347250580788,
0.0156550332903862,
-0.007009529042989016,
0.010149344801902771,
-0.010470247827470303,
-0.007940776646137238,
0.03294604271650314,
0.037501607090234756,
-0.04389449954032898,
-0.04157896339893341,
-0.00020390712597873062,
-0.0016894600121304393,
0.0043730903416872025,
0.07102653384208679,
-0.02698102407157421,
0.011099469847977161,
0.011143514886498451,
-0.0016296840040013194,
-0.019380025565624237,
0.006732671521604061,
-0.014761539176106453,
-0.018108997493982315,
-0.05879446864128113,
0.02034902758896351,
0.0022007026709616184,
0.002373738680034876,
0.01885147951543331,
0.008003698661923409,
-0.0015549638774245977,
0.016787633299827576,
0.017983153462409973,
0.039968159049749374,
-0.04882759973406792,
0.022878497838974,
-0.017983153462409973,
0.017957985401153564,
-0.030303312465548515,
-0.032140638679265976,
-0.06055628880858421,
-0.037526778876781464,
0.0039200508035719395,
0.0008038306259550154,
-0.00951383076608181,
0.02471582591533661,
-0.0026474499609321356,
0.06483499705791473,
0.024187279865145683,
0.03916275501251221,
-0.011086884886026382,
-0.042132679373025894,
0.044095851480960846,
-0.00040860078297555447,
0.03946477919816971,
0.015466267243027687,
0.03020263835787773,
-0.003662069793790579,
0.010281480848789215,
0.002365873195230961,
-0.03266918659210205,
-0.005537150427699089,
-0.048097699880599976,
0.015038397163152695,
-0.02146904170513153,
-0.003234199248254299,
-0.04512777552008629,
0.0313100665807724,
-0.024338291957974434,
-0.04429720342159271,
-0.008752472698688507,
-0.01863754354417324,
0.0164100993424654,
-0.00728638656437397,
0.001527435495518148,
-0.056076232343912125,
-0.011797904968261719,
-0.02808845229446888,
0.017655959352850914,
-0.0036274625454097986,
-0.037526778876781464,
0.00261598895303905,
0.013276576064527035,
0.001198667217977345,
-0.006587950512766838,
0.04943165183067322,
0.03254334256052971,
0.010124175809323788,
0.028440818190574646,
0.004388820845633745,
0.033852122724056244,
0.01649819128215313,
0.015730541199445724,
0.014283331111073494,
-0.06196574494242668,
0.039187923073768616,
-0.04417135939002037,
-0.029070038348436356,
-0.01812158338725567,
-0.011684645898640156,
0.0016831678804010153,
0.011332281865179539,
-0.051017288118600845,
0.02101600170135498,
0.005502542946487665,
0.019883403554558754,
-0.013389836065471172,
0.01984564960002899,
-0.04462439566850662,
0.05310630425810814,
0.0058391764760017395,
0.043642811477184296,
-0.017077075317502022,
-0.017265841364860535,
-0.04751881584525108,
0.02188432775437832,
-0.0042724148370325565,
0.018411025404930115,
0.05174718797206879,
-0.04019467905163765,
0.05079076811671257,
-0.01305005606263876,
-0.02233736775815487,
-0.012603309005498886,
0.0016642911359667778,
0.02962375432252884,
0.005650409962981939,
-0.01404422614723444,
0.022274445742368698,
0.019707221537828445,
0.01487479917705059,
-0.0026128427125513554,
0.05094178393483162,
-0.022563887760043144,
-0.027081698179244995,
-0.0027308217249810696,
-0.00024716611369512975,
0.01628425531089306,
0.0028661044780164957,
-0.039515119045972824,
0.0466630756855011,
0.04092457517981529,
0.07238565385341644,
-0.028944194316864014,
0.05522048845887184,
0.0024539644364267588,
-0.04678891971707344,
-0.026301464065909386,
-0.026326632127165794,
0.045807335525751114,
-0.004014433827251196,
-0.0073178475722670555,
0.03820633515715599,
0.024753578007221222,
0.022085679695010185,
0.03699823096394539,
-0.023444797843694687,
0.03664586693048477,
-0.01725325733423233,
-0.04324011132121086,
-0.02222410775721073,
-0.007575828116387129,
0.028340142220258713,
0.007305263075977564,
-0.004366797860711813,
-0.0806913822889328,
0.05617690458893776,
-0.004681408870965242,
-0.013792538084089756,
0.011307112872600555,
-0.010067545808851719,
-0.004077356308698654,
0.08225184679031372,
-0.02901970036327839,
0.08079205453395844,
0.04140278324484825,
0.0040270183235406876,
0.007506614085286856,
-0.031813446432352066,
0.004071063827723265,
-0.03833218291401863,
0.031108716502785683,
-0.001651706756092608,
0.054213736206293106,
0.027081698179244995,
0.005769962444901466,
-0.01671212539076805,
0.006043673492968082,
-0.011206436902284622,
0.03928859904408455,
0.031914122402668,
-0.014396591112017632,
-0.03548809885978699,
-0.056227244436740875,
0.04324011132121086,
-0.01770629733800888,
0.042736731469631195,
0.018083829432725906,
-0.04296325147151947,
0.007670211605727673,
0.009438324719667435,
0.012999719008803368,
0.03327323868870735,
0.004671970382332802,
0.014862215146422386,
0.009973162785172462,
-0.025244371965527534,
0.0030910512432456017,
0.04324011132121086,
0.014660864137113094,
-0.029120376333594322,
0.0017209211364388466,
0.0433659553527832,
-0.03845802694559097,
0.021179599687457085,
-0.033524926751852036,
0.03392763063311577,
-0.030127130448818207,
0.03760228306055069,
-0.018373271450400352,
-0.02929655835032463,
0.03709890693426132,
-0.022802991792559624,
0.019040245562791824,
0.012018132954835892,
-0.05350900813937187,
0.02562190406024456,
-0.02992578037083149,
-0.025898762047290802,
-0.02778642624616623,
0.027685752138495445,
-0.015264916233718395,
-0.020613299682736397,
0.041176263242959976,
-0.06548938900232315,
0.030479494482278824,
0.03556360676884651,
0.024212447926402092,
-0.014937721192836761,
0.02041194960474968,
-0.004332190845161676,
-0.018763389438390732,
0.02300434187054634,
0.034305162727832794,
-0.029674092307686806,
-0.008909777738153934,
-0.04107558727264404,
-0.0009186635725200176,
-0.02384749986231327,
-0.00019210923346690834,
0.002380030695348978,
-0.0035708327777683735,
0.020726559683680534,
0.04527878761291504,
-0.0034166735131293535,
0.01305005606263876,
0.013276576064527035,
-0.009023037739098072,
-0.01435883715748787,
-0.02944757230579853,
0.024552227929234505,
0.05366002023220062,
0.033801786601543427,
-0.009381694719195366,
-0.013339498080313206,
-0.03717441484332085,
0.048097699880599976,
-0.010199682787060738,
0.006952899042516947,
0.015063565224409103,
-0.012899043038487434,
-0.011690937913954258,
-0.01026889681816101,
-0.016070319339632988,
0.010835195891559124,
-0.007745718117803335,
-0.01833551749587059,
0.02185915969312191,
0.02884351834654808,
0.006289070006459951,
0.020739145576953888,
0.03188895061612129,
0.06392891705036163,
0.020122507587075233,
0.04500193148851395,
-0.009664843790233135,
0.017983153462409973,
-0.02974959835410118,
-0.005556026939302683,
0.05144516006112099,
-0.022173769772052765,
-0.047191619873046875,
-0.0424598753452301,
-0.05783805251121521,
-0.022991757839918137,
-0.007575828116387129,
-0.0034135272726416588,
-0.008916070684790611,
-0.007575828116387129,
-0.0036243165377527475,
0.015592112205922604,
0.01878855749964714,
-0.028591830283403397,
-0.026653828099370003,
-0.019279349595308304,
-0.035060230642557144,
-0.06664715707302094,
0.04407068341970444,
-0.02570999599993229,
-0.00927472673356533,
0.05401238426566124,
-0.005370406433939934,
-0.001695752260275185,
-0.04283740743994713,
0.02791227027773857,
-0.015139072202146053,
-0.02391042187809944,
-0.0013952989829704165,
-0.009356525726616383,
0.02839048020541668,
-0.010533169843256474,
0.003548810025677085,
0.0201728455722332,
0.0009304614504799247,
-0.03526157885789871,
0.034305162727832794,
-0.016095489263534546,
0.02698102407157421,
-0.03495955467224121,
0.015680203214287758,
-0.013893213123083115,
0.019077999517321587,
-0.011489586904644966,
-0.01457277312874794,
-0.04261088743805885,
-0.0021000271663069725,
-0.01803349144756794,
-0.025156280025839806,
-0.019077999517321587,
-0.0069654835388064384,
-0.01948070153594017,
-0.053005628287792206,
-0.000899786944501102,
0.011187560856342316,
-0.01920384354889393,
-0.02469065599143505,
0.0015085588674992323,
-0.006814470048993826,
0.0062261479906737804,
0.026628658175468445,
-0.020600715652108192,
0.032316822558641434,
0.012722861021757126,
-0.0018247426487505436,
0.0035739787854254246,
0.0009477650746703148,
0.031813446432352066,
-0.016447853296995163,
-0.013339498080313206,
0.0018813726492226124,
0.05803940072655678,
-0.029271390289068222,
0.027106868103146553,
-0.052099552005529404,
-0.011426664888858795,
-0.01695123128592968,
-0.013276576064527035,
0.02471582591533661,
0.01442175917327404,
0.04500193148851395,
0.0379294790327549,
-0.03249300643801689,
0.022752653807401657,
0.02216118574142456,
-0.009381694719195366,
-0.023193109780550003,
0.01800832338631153,
0.0003360436821822077,
-0.013868044130504131,
-0.022136015817523003,
-0.027710920199751854,
-0.024740993976593018,
0.01974497362971306,
-0.010596091859042645,
-0.0010020354529842734,
0.008727303706109524,
0.004816691391170025,
0.03694789484143257,
0.023432213813066483,
-0.03838251903653145,
0.015969645231962204,
0.015768293291330338,
0.00621670950204134,
-0.010816319845616817,
-0.014321084134280682,
0.0173161793500185,
-0.015478852204978466,
-0.016938645392656326,
-0.013314329087734222,
-0.019795311614871025,
0.0017571013886481524,
-0.012232067994773388,
-0.02917071431875229,
-0.010080130770802498,
0.012030716985464096,
-0.006638288032263517,
-0.004612194374203682,
-0.016384931281208992,
-0.02579808607697487,
-0.01610807329416275,
0.007085035555064678,
-0.0082050496712327,
-0.012559263966977596,
0.01404422614723444,
-0.008884609676897526,
0.0014786708634346724,
-0.0035708327777683735,
0.0007173126214183867,
-0.011325988918542862,
-0.014648279175162315,
-0.03007679432630539,
0.026804840192198753,
-0.02884351834654808,
-0.014648279175162315,
0.00016664541908539832,
0.015617280267179012,
0.010356987826526165,
0.012578140012919903,
-0.02460256591439247,
-0.009268434718251228,
-0.033801786601543427,
0.0045807333663105965,
-0.04588283970952034,
0.002947903238236904,
0.0027827327139675617,
0.08300691843032837,
0.06770424544811249,
-0.026628658175468445,
0.03453168272972107,
-0.02146904170513153,
0.0005694455467164516,
0.0037753297947347164,
0.005474227946251631,
0.04965817183256149,
0.00709762005135417,
0.0075884126126766205,
0.017467191442847252,
0.08728562295436859,
0.028314972296357155,
0.015365592204034328,
-0.006210417486727238,
-0.008878316730260849,
0.01643526926636696,
-0.0014440636150538921,
-0.014509850181639194,
-0.03868454694747925,
0.026452476158738136,
-0.021129261702299118,
0.02107892371714115,
-0.025269540026783943,
-0.07223464548587799,
-0.00252160569652915,
0.0021000271663069725,
-0.007015821058303118,
0.004876467399299145,
0.018838895484805107,
-0.0002811833983287215,
-0.021116677671670914,
0.02119218371808529,
-0.025735164061188698,
0.008953823707997799,
0.023142771795392036,
0.015239747241139412,
-0.005354675929993391,
-0.012829829007387161,
0.015755709260702133,
0.017366517335176468,
0.032266486436128616,
0.029120376333594322,
0.032769862562417984,
-0.022563887760043144,
0.024162109941244125,
-0.015201994217932224,
-0.01020597480237484,
-0.05214988812804222,
0.028012946248054504,
0.047946687787771225,
0.017693711444735527,
0.007292678579688072,
-0.03594113886356354,
-0.025332462042570114,
-0.015340423211455345,
-0.003045432735234499,
-0.003898028051480651,
0.03923825919628143,
0.010740812867879868,
0.025181449949741364,
-0.015793463215231895,
0.029523078352212906,
-0.049456819891929626,
-0.008513368666172028,
0.03745127096772194,
0.028264636173844337,
-0.028591830283403397,
0.03787914291024208,
-0.030806690454483032,
0.008683258667588234,
0.0040270183235406876,
-0.036142490804195404,
-0.009073375724256039,
0.013213654048740864,
0.0005859626107849181,
0.01948070153594017,
-0.011187560856342316,
-0.005584341939538717,
-0.021745899692177773,
-0.024048849940299988,
0.033373914659023285,
-0.008406400680541992,
-0.006814470048993826,
0.030127130448818207,
-0.001400018110871315,
0.022626809775829315,
0.030504664406180382,
0.022714899852871895,
0.008387524634599686,
-0.043340783566236496,
-0.0027827327139675617,
0.0100864227861166,
-0.013603771105408669,
0.0043730903416872025,
0.014962890185415745,
-0.02667899616062641,
-0.0036180242896080017,
0.004999165888875723,
-0.01909058354794979,
-0.0006551769911311567,
-0.006462106015533209,
0.015076150186359882,
-0.014472097158432007,
0.028667336329817772,
0.006119180470705032,
-0.004731746390461922,
0.013930967077612877,
0.025030435994267464,
-0.010608676820993423,
0.005842322949320078,
-0.029372066259384155,
-0.006065696477890015,
0.0003456786216702312,
0.003300267504528165,
-0.011665768921375275,
0.01725325733423233,
-0.03571461886167526,
0.036746542900800705,
-0.020877573639154434,
-0.00435735983774066,
-0.01812158338725567,
-0.020726559683680534,
-0.005030626896768808,
0.01863754354417324,
-0.010187097825109959,
-0.012615893967449665,
-0.007160542067140341,
0.012213191948831081,
-0.018461361527442932,
-0.015101319178938866,
-0.018260011449456215,
0.04054704308509827,
-0.025332462042570114,
0.004520957358181477,
-0.007538075093179941,
0.05144516006112099,
0.022526133805513382,
-0.07379510998725891,
-0.012099931947886944,
-0.013830291107296944,
-0.0015203567454591393,
0.011414079926908016,
-0.006049965973943472,
-0.03624316677451134,
-0.007085035555064678,
0.0041906158439815044,
-0.013238823041319847,
0.013943551108241081,
-0.011779028922319412,
-0.0005989403580315411,
-0.003643193282186985,
-0.008267971687018871,
-0.028566662222146988,
-0.022966589778661728,
-0.039338935166597366,
0.0075632440857589245,
0.03495955467224121,
0.00826167967170477,
-0.0020701391622424126,
-0.014346253126859665,
0.07721807807683945,
0.009866194799542427,
0.024740993976593018,
-0.027358556166291237,
0.009935409761965275,
-0.028289804235100746,
-0.0028723967261612415,
0.032920874655246735,
0.02974959835410118,
-0.0005560746067203581,
0.05099212005734444,
0.008966407738626003,
-0.01695123128592968,
0.017567867413163185,
-0.005093548912554979,
-0.014686033129692078,
0.011483294889330864,
0.020399365574121475,
0.005414451938122511,
0.03526157885789871,
0.01201184093952179,
-0.013704447075724602,
-0.006075134966522455,
-0.029950948432087898,
-0.006569073535501957,
0.01479929219931364,
-0.00994799379259348,
0.03171277046203613,
-0.007840101607143879,
-0.03387729078531265,
0.0015085588674992323,
-0.018448777496814728,
0.008733595721423626,
-0.0052162474021315575,
0.027836764231324196,
0.034733034670352936,
-0.0034638650249689817,
-0.03271952271461487,
0.047342635691165924,
0.03898657113313675,
-0.009236973710358143,
-0.004379382357001305,
-0.014081980101764202,
-0.04230886325240135,
0.023256031796336174,
-0.039187923073768616,
0.008727303706109524,
-0.0038382518105208874,
0.009910240769386292,
-0.05522048845887184,
0.03203996643424034,
-0.010828903876245022,
0.0082050496712327,
0.004690847359597683,
-0.012282405979931355,
0.003064309246838093,
0.01586896926164627,
-0.017391685396432877,
-0.024791331961750984,
-0.005829738453030586,
0.00038126896834000945,
-0.02959858439862728,
-0.003747014794498682,
-0.007248633075505495,
0.017454607412219048,
0.003602293785661459,
0.016447853296995163,
-0.016120657324790955,
-0.014686033129692078,
0.011980379931628704,
-0.002285647438839078,
-0.008783933706581593,
0.0005541082937270403,
-0.032316822558641434,
-0.000025009101591422223,
-0.0063708689995110035,
-0.02146904170513153,
0.05325731635093689,
-0.044423047453165054,
0.012653646990656853,
-0.009935409761965275,
-0.01893957145512104,
-0.02393558993935585,
0.03055500239133835,
0.006399183999747038,
0.02318052388727665,
-0.03040398843586445,
0.0230295117944479,
-0.00977181177586317,
0.01797056943178177,
-0.016208749264478683,
0.01893957145512104,
-0.02432570792734623,
0.005820299964398146,
0.006254462990909815,
0.002935318974778056,
0.02839048020541668,
0.06302283704280853,
0.026930686086416245,
0.007752010598778725,
-0.004514665342867374,
-0.0036400470416992903,
0.017832141369581223,
-0.022740069776773453,
0.029120376333594322,
0.03709890693426132,
-0.009885071776807308,
0.0215319637209177,
0.0017130558844655752,
0.022601639851927757,
0.004760061390697956,
-0.005250854417681694,
0.04928063601255417,
0.01740426942706108,
0.013364667072892189,
0.02224927581846714,
0.01751752942800522,
0.008079205639660358,
0.0015164241194725037,
0.0030627362430095673,
-0.03261885046958923,
0.02947274036705494,
-0.00610344996675849,
-0.026427308097481728,
0.03533708676695824,
-0.0037816220428794622,
0.02977476641535759,
-0.04699027165770531,
-0.0011727118398994207,
0.04447338357567787,
0.06548938900232315,
0.0010681037092581391,
0.03395279869437218,
0.029523078352212906,
-0.00621670950204134,
-0.03639417886734009,
-0.006468398496508598,
-0.009778103791177273,
0.05184786021709442,
-0.025898762047290802,
-0.01356601808220148,
0.02791227027773857,
-0.012257236987352371,
-0.026578322052955627,
-0.012395665980875492,
0.01948070153594017,
0.013389836065471172,
-0.013968720100820065,
-0.06010324880480766,
0.03601664677262306,
-0.019254181534051895,
-0.030429158359766006,
-0.01839843951165676,
0.012446003966033459,
-0.0006870313663966954,
0.032769862562417984,
0.024162109941244125,
-0.05295529216527939,
-0.0007184924324974418,
0.02399851195514202,
0.04389449954032898,
0.006289070006459951,
-0.02947274036705494,
0.006518736016005278,
-0.05051391199231148,
-0.011206436902284622,
-0.0030674554873257875,
-0.03908724710345268,
-0.028667336329817772,
-0.0004286572220735252,
0.055623192340135574,
0.02667899616062641,
-0.01797056943178177,
-0.020701391622424126,
-0.004882759880274534,
-0.05456610023975372,
-0.022626809775829315,
-0.017215503379702568,
0.04925546795129776,
0.051797524094581604,
-0.020047001540660858,
-0.008179880678653717,
0.020525209605693817,
-0.006374015007168055,
-0.012590724974870682,
0.03216581046581268,
0.013100394047796726,
-0.010879241861402988,
0.025659658014774323,
-0.015944475308060646,
0.008242803625762463,
0.02851632423698902,
-0.02369648590683937,
0.021808821707963943,
-0.008563706651329994,
-0.024011097848415375,
-0.019166091457009315,
-0.035186074674129486,
-0.0376274548470974,
0.004741184879094362,
0.006449521519243717,
-0.0027009337209165096,
0.016699541360139847,
0.01833551749587059,
0.019518455490469933,
-0.013490512035787106,
0.020827235653996468,
-0.009299895726144314,
0.025898762047290802,
0.034632358700037,
-0.0016831678804010153,
0.011231605894863605,
-0.0035676865372806787,
-0.022299613803625107,
-0.021594885736703873,
0.015793463215231895,
-0.006273339502513409,
0.030857028439641,
0.006707502529025078,
0.006024796981364489,
-0.03470786288380623,
-0.015201994217932224,
0.009551583789288998,
0.034128982573747635,
-0.02477874793112278,
0.009639674797654152,
-0.0023878959473222494,
-0.03848319500684738,
0.012049593962728977,
0.030806690454483032,
0.04286257550120354,
0.06493566930294037,
-0.0023517159279435873,
-0.006090865470468998,
0.000019011833501281217,
0.023042095825076103,
-0.010564630851149559,
-0.010275188833475113,
-0.0007546726847067475,
-0.0033757740166038275,
0.0020465434063225985,
0.03589080274105072,
-0.0011357450857758522,
0.0018624960212036967,
0.0035299332812428474,
0.00015956666902638972,
0.021091509610414505,
0.035060230642557144,
0.004156008828431368,
-0.002716664457693696,
-0.013528265058994293,
0.0016406953800469637,
-0.001136531587690115,
0.01231386698782444,
-0.011709813959896564,
-0.014887383207678795,
0.0013426016084849834,
-0.011961502954363823,
0.005688163451850414,
-0.043793823570013046,
0.007814932614564896,
0.01598222926259041,
0.00963338278234005,
0.0024335146881639957,
-0.01550402119755745,
0.005612656939774752,
-0.01255297102034092,
-0.03224131464958191,
0.020764313638210297,
-0.014786708168685436,
-0.012559263966977596,
-0.008242803625762463,
-0.03297121450304985,
0.012741737999022007,
-0.009186635725200176,
-0.0030941972509026527,
-0.01695123128592968,
0.03865937516093254,
0.024048849940299988,
-0.002386322943493724,
-0.011533631943166256,
0.004322752356529236,
-0.008865732699632645,
-0.024577395990490913,
-0.02369648590683937,
0.039187923073768616,
-0.018146751448512077,
-0.030932534486055374,
0.006090865470468998,
0.009601921774446964,
-0.007972237654030323,
0.02170814573764801,
-0.0004274774400983006,
-0.019128337502479553,
0.016926061362028122,
-0.0025530667044222355,
0.03803015500307083,
-0.030806690454483032,
0.00927472673356533,
0.016699541360139847,
-0.00771425710991025,
-0.03699823096394539,
0.005738500971347094,
0.011640599928796291,
-0.011464417912065983,
-0.01189228892326355,
-0.010923286899924278,
0.01956879161298275,
0.005187932401895523,
0.009186635725200176,
-0.0033663357608020306,
0.01803349144756794,
0.015063565224409103,
0.015441098250448704,
-0.026351802051067352,
0.013779953122138977,
-0.018134167417883873,
-0.016988983377814293,
0.006059403996914625,
0.013490512035787106,
-0.01264735497534275,
0.016938645392656326,
-0.0038665668107569218,
-0.016246503219008446,
-0.0192667655646801,
-0.013704447075724602,
-0.012339035980403423,
0.06448262929916382,
-0.02391042187809944,
-0.031209392473101616,
0.029548248276114464,
-0.008009991608560085,
-0.009413155727088451,
-0.01857462152838707,
0.02348255179822445,
0.005552880931645632,
-0.004590171854943037,
-0.004171739332377911,
0.028642168268561363,
0.03163726255297661,
-0.008450446650385857,
-0.0062292939983308315,
0.02884351834654808,
-0.021204767748713493,
-0.004822983872145414,
-0.015139072202146053,
0.0024193571880459785,
0.01034440379589796,
-0.0050369189120829105,
-0.025206618010997772,
-0.004391966853290796,
0.011407787911593914,
0.020588131621479988,
0.039640963077545166,
0.022362535819411278,
-0.016573697328567505,
0.03065567836165428,
0.01803349144756794,
-0.006569073535501957,
-0.01195521093904972,
-0.021896911785006523,
-0.0011742848437279463,
0.007229756563901901,
-0.029095208272337914,
-0.036293502897024155,
-0.006820762529969215,
-0.005191078409552574,
-0.026049776002764702,
-0.013943551108241081,
-0.0015879981219768524,
0.003979826811701059,
-0.014849630184471607,
-0.021481625735759735,
-0.02430053986608982,
-0.01088553387671709,
-0.012401957996189594,
0.02508077397942543,
-0.027861934155225754,
-0.037853971123695374,
0.016510775312781334,
-0.018260011449456215,
-0.006304800510406494,
0.027736088261008263,
0.00391375832259655,
-0.005930413957685232,
0.03438067063689232,
0.026150450110435486,
-0.02315535582602024,
0.004307021852582693,
-0.05366002023220062,
0.006946606561541557,
-0.04736780375242233,
-0.0019159798976033926,
0.014384006150066853,
-0.011734982952475548,
-0.022954003885388374,
-0.0009320345125161111,
0.02047487162053585,
0.0035267872735857964,
-0.022450627759099007,
0.005810861475765705,
-0.007638750597834587,
0.007928192615509033,
0.009387986734509468,
0.009878779761493206,
-0.04278707131743431,
0.011074300855398178,
-0.008072913624346256,
0.04407068341970444,
0.023583225905895233,
-0.014509850181639194,
-0.016988983377814293,
0.01356601808220148,
-0.0007361893076449633,
0.01878855749964714,
-0.019291935488581657,
-0.012401957996189594,
-0.013540849089622498,
-0.017089659348130226,
0.0313100665807724,
-0.0025168864522129297,
0.010728228837251663,
-0.012540386989712715,
0.004212638828903437,
-0.004961412400007248,
0.028768012300133705,
0.002716664457693696,
0.01999666355550289,
0.03284537047147751,
-0.017442023381590843,
-0.019191259518265724,
-0.024791331961750984,
-0.007890439592301846,
-0.017869893461465836,
-0.019229013472795486,
0.0028283512219786644,
0.026427308097481728,
-0.03405347466468811,
-0.0039200508035719395,
0.002087442670017481,
0.019380025565624237,
-0.0008415839402005076,
-0.001983621157705784,
-0.0034607190173119307,
-0.014094564132392406,
-0.01815933547914028,
0.0011577678378671408,
0.02534504607319832,
0.016837971284985542,
0.018448777496814728,
-0.002199129667133093,
0.018977323547005653,
-0.03986748307943344,
0.042258523404598236,
-0.003021836746484041,
0.030731184408068657,
-0.028591830283403397,
-0.04079873114824295,
-0.007066159043461084,
-0.008614043705165386,
-0.02023576758801937,
0.017265841364860535,
0.015302670188248158,
-0.006852223537862301,
-0.006138056982308626,
0.05451576039195061,
0.0021440726704895496,
-0.02393558993935585,
-0.022362535819411278,
-0.026729334145784378,
-0.004039602819830179,
-0.00276542897336185,
-0.00006198816117830575,
0.010017207823693752,
-0.005414451938122511,
-0.01044507883489132,
-0.023860083892941475,
-0.01625908724963665,
-0.018058661371469498,
0.011451833881437778,
-0.013226238079369068,
-0.0005914682988077402,
0.008009991608560085,
-0.034632358700037,
-0.05506947636604309,
0.005955582484602928,
0.011489586904644966,
-0.014522435143589973,
-0.008513368666172028,
-0.008645504713058472,
-0.0037186997942626476,
0.037199582904577255,
-0.04054704308509827,
0.012357912957668304,
0.02162005566060543,
0.013352083042263985,
0.0010759689612314105,
-0.008620336651802063,
0.016221333295106888,
0.009425739757716656,
-0.0019128337735310197,
0.007519198581576347,
-0.025999438017606735,
0.003687238786369562,
0.018952155485749245,
-0.0017083367565646768,
0.027333388105034828,
0.03113388642668724,
-0.003938927315175533,
0.00261126970872283,
0.004259830340743065,
-0.013175901025533676,
0.05431441217660904,
-0.010300357826054096,
-0.011615430936217308,
-0.021242521703243256,
-0.01764337345957756,
-0.01900249347090721,
0.027509570121765137,
0.004533541854470968,
-0.00931877177208662,
-0.007550659589469433,
0.020789481699466705,
0.014472097158432007,
-0.01350309606641531,
-0.019380025565624237,
-0.0011845097178593278,
0.04777050390839577,
0.01312556304037571,
-0.005055795889347792,
-0.01101767085492611,
-0.01195521093904972,
-0.04827388375997543,
0.013465343043208122,
-0.01574312523007393,
-0.02441379986703396,
0.005442766938358545,
0.022022757679224014,
0.014472097158432007,
0.009104836732149124,
0.025156280025839806,
0.008991576731204987,
-0.00814212765544653,
-0.026301464065909386,
-0.02224927581846714,
-0.006282777991145849,
-0.01604515127837658,
0.013868044130504131,
0.009551583789288998,
-0.023507719859480858,
0.022287029772996902,
-0.014081980101764202,
0.014333668164908886,
0.01356601808220148,
0.015906723216176033,
0.006531320512294769,
-0.010262604802846909,
-0.02525695599615574,
0.029422402381896973,
-0.012590724974870682,
0.02698102407157421,
-0.012729153037071228,
-0.0188137274235487,
-0.02914554625749588,
-0.0038697130512446165,
-0.019984079524874687,
-0.008047744631767273,
-0.027861934155225754,
-0.0017319325124844909,
-0.004797814879566431,
-0.029120376333594322,
0.020210597664117813,
0.028314972296357155,
-0.0061883945018053055,
0.021808821707963943,
-0.023532887920737267,
-0.006795593537390232,
-0.00441713584586978,
0.024791331961750984,
-0.011263066902756691,
-0.018977323547005653,
-0.015957061201334,
-0.007418523076921701,
-0.008538537658751011,
-0.02119218371808529,
-0.001651706756092608,
0.007550659589469433,
-0.036268334835767746,
0.012999719008803368,
0.0055906339548528194,
-0.02053779363632202,
-0.015038397163152695,
0.014635695144534111,
-0.027962608262896538,
-0.008765057660639286,
0.01751752942800522,
0.021808821707963943,
0.01243341900408268,
0.04777050390839577,
-0.019984079524874687,
-0.005055795889347792,
0.010369572788476944,
0.016359761357307434,
-0.022538717836141586,
0.018020907416939735,
0.04419652745127678,
-0.037224750965833664,
0.0008289995021186769,
0.005961874965578318,
-0.0037155537866055965,
-0.03422965481877327,
-0.013628940097987652,
-0.017718881368637085,
0.006833347026258707,
0.03483371064066887,
-0.025823256000876427,
0.018750803545117378,
0.004262976348400116,
0.01954362355172634,
-0.0021676684264093637,
0.02839048020541668,
-0.03508539870381355,
0.0065124440006911755,
-0.020902741700410843,
-0.022714899852871895,
0.01593189127743244,
-0.0007688301848247647,
-0.017693711444735527,
0.025194033980369568,
0.01058350782841444,
0.009759227745234966,
0.029070038348436356,
-0.013830291107296944,
-0.005807715468108654,
0.03896140307188034,
-0.01740426942706108,
0.0013370959786698222,
0.02610011212527752,
-0.020676221698522568,
-0.0015832788776606321,
0.008500783704221249,
0.00351105653680861,
-0.007877854630351067,
0.023407043889164925,
0.02242545783519745,
-0.02622595801949501,
0.008846855722367764,
-0.025974268093705177,
-0.0001393136044498533,
-0.018046075478196144,
-0.00391375832259655,
0.11537407338619232,
-0.0006225361139513552,
0.0018609229009598494,
0.0061223264783620834,
-0.006984360050410032,
-0.022362535819411278,
0.01274803001433611,
-0.009457200765609741,
0.04497676342725754,
-0.008293140679597855,
0.015390761196613312,
0.004011287819594145,
0.02538280002772808,
-0.00261598895303905,
0.015277501195669174,
-0.02408660389482975,
0.007858977653086185,
0.03971646726131439,
-0.008991576731204987,
-0.0011845097178593278,
0.007343016564846039,
0.008236510679125786,
-0.0028629584703594446,
0.01487479917705059,
-0.01357860304415226,
-0.018171921372413635,
-0.015390761196613312,
0.014081980101764202,
-0.013402420096099377,
0.002057554665952921,
0.005961874965578318,
0.00467511685565114,
0.004835568368434906,
-0.01785730943083763,
-0.018763389438390732,
-0.03815599903464317,
0.003388358512893319,
-0.0047632078640162945,
0.012087346985936165,
0.0022274444345384836,
-0.009312479756772518,
0.01776921935379505,
0.01535300724208355,
0.01677504926919937,
0.05411306023597717,
0.02240028977394104,
-0.04097491130232811,
-0.018171921372413635,
0.012112515978515148,
-0.025395384058356285,
-0.005235123913735151,
0.008809102699160576,
0.003945219796150923,
-0.019417779520154,
-0.009413155727088451,
-0.02053779363632202,
0.015856385231018066,
-0.015378176234662533,
-0.011797904968261719,
-0.024074019864201546,
-0.012949381023645401,
0.006978067569434643,
0.019342273473739624,
-0.0002717450843192637,
-0.005990189965814352
] | 2024-12-23 | 45 | 39713739 | [
"CAR T cells",
"primary T cells",
"CAR surface density",
"pro-inflammatory cytokine release",
"CAR T-cell therapies",
"CAR T-cell therapy",
"cytokine release syndrome",
"CAR expression density",
"various blood cancers",
"CAR gene",
"other hematologic malignancies",
"cancer treatment",
"CAR) T-cell therapy",
"CAR",
"each T cell",
"CRS",
"unprecedented efficacy",
"Chimeric antigen receptor",
"solid tumors",
"recent years",
"uniformly mixing and shearing cells",
"dosage-controlled delivery",
"most notably B-cell acute lymphoblastic leukemia",
"patients",
"an unexpected side effect",
"mRNA",
"an acoustic-electric microfluidic platform",
"(CRS",
"the surface",
"the remarkable success"
] | [] | 0 | 10.1063/5.0231595
10.1056/NEJMoa1709919
10.1056/NEJMoa1709866
10.1038/nrd.2017.266
10.1056/NEJMoa1707447
10.1001/jama.2020.15848
10.1093/jnci/djac088
10.1038/mto.2016.11
10.1016/j.omtm.2021.03.007
10.1126/sciadv.abo0514
10.1038/mto.2016.15
10.1172/JCI35700
10.3390/diseases6020042
10.1038/nature21405
10.1111/imr.12137
10.1016/S0006-3495(01)76055-9
10.1155/2021/6644685
10.1073/pnas.1809671115
10.1073/pnas.1818553116
10.1038/s41598-020-73755-0
10.1038/s41598-019-40147-y
10.1016/j.mattod.2018.03.002
10.1038/s41598-018-34601-6
10.1021/nn400874a
10.1016/j.mtbio.2021.100193
10.1002/advs.202102021
10.1038/nrd.2017.243
10.3390/ijms21186514
10.1038/s41573-018-0006-z
10.1158/2326-6066.CIR-13-0006
10.3389/fimmu.2022.867013
10.1016/j.jconrel.2010.10.020
10.1002/INMD.20230036
10.1016/j.omtm.2020.01.012
10.1038/s41586-019-0979-8
10.1007/BF00286790
10.1039/B812435C
10.1016/j.cell.2016.03.014
10.1002/adhm.202203163
10.1158/2159-8290.CD-19-0945
10.1182/bloodadvances.2020002394
10.1007/s00232-010-9279-9
10.1038/s41598-023-45197-x
10.15252/emmm.201607485
10.1038/s41591-020-1061-7
10.1038/s41467-020-19486-2 | [
"Chen",
"Mirza",
"Jiang",
"Lee"
] | [
"Department of Biomedical Engineering, University of California, Irvine, California 92697, USA.",
"Department of Biomedical Engineering, University of California, Irvine, California 92697, USA.",
"Department of Biomedical Engineering, University of California, Irvine, California 92697, USA.",
null
] | [
"39713739",
"29385376",
"29385370",
"29375140",
"29226797",
"32870282",
"35438170",
"27626062",
"33869653",
"36179026",
"27347557",
"18688285",
"29883422",
"28225754",
"24329797",
"11159443",
"33855089",
"30381459",
"30923112",
"33093518",
"30824814",
"30288138",
"30389991",
"23597131",
"35005598",
"34716688",
"29326426",
"32899932",
"30622344",
"24777247",
"35757746",
"20970469",
"32083149",
"30814730",
"6168440",
"19209333",
"27104977",
"36645182",
"32193224",
"33035333",
"20617432",
"37875523",
"28765140",
"33020644",
"33247092"
] | [] | 6.512552 | 4.31325 |
Subsets and Splits