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Traditional use; LCMS; MZmine; GNPS; alkaloid; flavonoid | https://doi.org/10.55373/mjchem.v26i1.65 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0048-9bf26ac | [
"Muhammad Farhan Syakir Nor Azman - Universiti Teknologi MARA",
"Nurulfazlina Edayah Rasol - Universiti Teknologi MARA",
"Mazlyana Mohd Zainul - Universiti Teknologi MARA",
"Fatimah Salim - Universiti Teknologi MARA",
"Zikry Hamizan Md Zakri - Universiti Malaysia Sabah",
"Monica Suleiman - Universiti Malaysia Sabah",
"Ng Shean Yeaw - Universiti Malaysia Sabah",
"Adlin Afzan - Institute for Medical Research"
] | The leaves of Albertisia papuana Becc. (Menispermaceae) is traditionally used by the people of Borneo as rice wine’s flavor enhancer and utilized for the treatment of symptoms associated with hypertension, stroke, and cancer. Despite its potential, this plant’s part remains largely unexplored from a scientific standpoint. Thus, this work aimed to profile and identify the phytochemicals of the methanolic leaf extract of A. papuana Becc. through liquid chromatography tandem mass spectrometry-based data analysis with MZmine and global natural products social molecular networking (GNPS) platforms. The present study managed to identify a total of 21 phytochemicals from different classes of compounds including alkaloids, flavonoids, terpenoid and several other phytochemicals. Of these, three compounds (nicotiflorin 11, isorhoifolin 12, and genistein 17) are first time reported in the family meanwhile 18 compounds (5'-deoxy-5'-(methylsulfinyl) adenosine 1, coclaurine 2, magnoflorine 3 isoschaftoside 4, reticuline 5, isovitexin 6, sinapic acid 7, dicoumaroyl spermidine 8, apigenin 9, loliolide 10, liriodenine 13, moupinamide 14, paprazine 15, ferulic acid 16, n-acetylanonaine 18, 13S-Hydroxy-9Z,11E,15Z-octadecatrienoic acid 19, 2-hydroxy-3-(2-hydroxyacetoxy) propyl palmitate 20, and monoelaidin 21) are new to the genus and the species. Some of the identified phytochemicals such as moupinamide 2, apigenin 9 and magnoflorine 11 have been previously reported to exhibit biological activities related to hypertension, stroke, cancer treatment, and flavor enhancing properties of certain foods. The findings provide evidence to support the plant’s traditional uses. | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-pdf.php?idx=J0048-9bf26ac | 26 February 2024 | Phytochemical Identification of Albertisia papuana Becc. Leaf Methanolic Extract through Liquid Chromatography Tandem Mass Spectrometry Data Analysis | Phytochemical Identification of Albertisia papuana Becc. Leaf Methanolic Extract through Liquid Chromatography Tandem Mass Spectrometry Data Analysis | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | Vol 26 No 1 (2024): Malaysian Journal of Chemistry |
Traditional use; alkaloid; flavonoid; chemometric; Erythrina | https://doi.org/10.55373/mjchem.v26i1.50 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0048-73a04cc | [
"Adiez Sapura Azmi - Universiti Teknologi MARA",
"Amerul Afiq Aspa - Universiti Teknologi MARA",
"Juliana Yusoff - Universiti Teknologi MARA",
"Fatimah Salim - Universiti Teknologi MARA",
"Muhammad Adam Azidi - International Islamic University Malaysia",
"Hazarul Izham Roszaiman - International Islamic University Malaysia",
"Ahmed Mediani - Universiti Kebangsaan Malaysia"
] | Erythrina fusca Lour., (Fabaceae) is a flowering plant locally known as "Chengkering", and has been traditionally used to treat certain symptoms associated with bacterial infections. However, limited study is available to support this traditional use, particularly the activity of the flower part against bacterial strains that commonly cause infection on human skin. The present work reports on the in vitro antibacterial activity of E. fusca flower’s extracts [hexane, dichloromethane (DCM), and methanol (MeOH)] against skin infectious bacterial strains namely Staphylococcus aureus, Staphylococcus haemolyticus, Enterobacter cloacae, and Enterobacter aerogenes evaluated through well diffusion method. The variation of the phytochemicals in the extracts and their correlation with the antibacterial activity were determined through proton nuclear magnetic resonance (1H-NMR)-based chemometric analysis. The hexane extract was active against S. aureus and S. haemolyticus strains with 14.00 ± 0.00 and 9.67 ± 0.33 mm zone of inhibition (ZOI), respectively. MeOH extract showed activity against E. cloacae (8.33 ± 0.33 mm) and E. aerogenes (8.17 ± 0.17 mm) strains. While DCM extract was only active against S. aureus (9.67 ± 0.33 mm). The NMR analysis on the extracts lead to the identification of 75 phytochemicals mainly from the alkaloids, flavonoids, pterocarpans, terpenes, saponins, sterols, and phenols classes of compounds. The chemometric analysis revealed the activity against S. haemolyticus was correlated with the flavonoid 5,3′-dihydroxy-4′-methoxy-5′-(3-methyl-1,3-butadienyl)-2′′,2′′-dimethylpyrano-[5,6:6,7]-isoflavanone (47), and the pterocarpans sandwicensin (58) and neorautenol (52). While the activity on E. cloacae, and E. aerogenes was collectively contributed by the alkaloids erysotrine N-oxide (11), 10-hydroxy-11-oxoerysotrine (18), and magnoflorine (33). This suggests that the therapeutic value reported for the plant could be synergically contributed by the above-mentioned phytochemicals. The finding provides evidence to support the plant's traditional use and could be the source of antibacterial agents for further studies. | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-pdf.php?idx=J0048-73a04cc | 26 February 2024 | 1H-NMR Based Chemometric Approach for Phytochemicals Variation Study on Erythrina fusca Flower Extracts and Correlation with Their Antibacterial Activity | 1H-NMR Based Chemometric Approach for Phytochemicals Variation Study on Erythrina fusca Flower Extracts and Correlation with Their Antibacterial Activity | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | Vol 26 No 1 (2024): Malaysian Journal of Chemistry |
Dipterocarpus kerrii; resveratrol oligomers; (+)-α-viniferin; (-)-laevifonol; radical scavenging | https://doi.org/10.55373/mjchem.v26i1.8 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0048-732fd78 | [
"Siti Zakirah Azahar - Universiti Teknologi MARA",
"Noorazlina Adnan - Universiti Teknologi MARA",
"Nurunajah Ab. Ghani - Universiti Teknologi MARA",
"Nik Fatini Nik Azmin - Universiti Teknologi MARA",
"Aisyah Salihah Kamarozaman - Universiti Teknologi MARA"
] | The Dipterocarpus genus is a member of the Dipterocarpaceae family, which exhibits a broad distribution in the tropical region of Southeast Asia, particularly in countries such as Malaysia, Cambodia, Indonesia, Thailand, and the Philippines. There has been limited research conducted thus far regarding the chemical constituents and bioactivities of this genus. Hence, Dipterocarpus kerrii was selected to be phytochemically studied as well as to evaluate the radical scavenging properties of the crude extract. The twigs of D. kerrii were collected from Jengka Forest Reserve, Universiti Teknologi MARA, Cawangan Pahang and air-dried for two weeks before being ground to granulated form. The granules (650 g) were macerated in acetone, followed by filtration and evaporation to give a crude acetone extract. The crude acetone extract (178 g) was subjected to fractionation and purification by vacuum liquid chromatography and column chromatography respectively to afford two resveratrol oligomers namely (+)-α-viniferin (1) (12 mg) and (-)-laevifonol (2) (5 mg). In addition, the crude acetone extract that was tested against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radicals exhibited potent radical scavenging activities with the IC50 values of 11.20 ± 0.54 and 32.37 ± 0.28 µg/mL, respectively. | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-pdf.php?idx=J0048-732fd78 | 26 February 2024 | Chemical Constituents and Radical Scavenging Activities from the Twigs of Dipterocarpus kerrii King | Chemical Constituents and Radical Scavenging Activities from the Twigs of Dipterocarpus kerrii King | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | Vol 26 No 1 (2024): Malaysian Journal of Chemistry |
Strobilanthes crispa; phytochemical screening; PDT treatment; A431 cells; photocytotoxicity | https://doi.org/10.55373/mjchem.v26i1.40 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0048-6a2f632 | [
"Chee-Shien Chen - Tunku Abdul Rahman University of Management and Technology",
"Chui-Fung Loke - Tunku Abdul Rahman University of Management and Technology",
"Siow-Ping Tan - Tunku Abdul Rahman University of Management and Technology",
"Tze-Ven Poh - Tunku Abdul Rahman University of Management and Technology",
"Ee-Lynn Fong - Universiti Putra Malaysia",
"Oi-Ming Lai - Universiti Putra Malaysia"
] | Strobilanthes crispa (L.) Blume (S. crispa) is a well-known folklore medicinal plant traditionally used in Malaysia and Indonesia for its diverse range of traditional applications and medicinal properties. While previous studies have established its effectiveness as an anticancer agent against various cancer types, its impact on skin cancer cells remains largely unexplored. In this study, ethanol, hexane, and ethyl acetate leaf extracts of S. crispa were screened for phytochemicals and analyzed for their photocytotoxicity against the A431 human skin squamous carcinoma cell line by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenultetrazolium bromide (MTT) assay. In general, the qualitative analysis indicated the presence of terpenes, alkaloids, phenols, quinones, and chlorophylls in all three crude extracts, while steroids, flavonoids, and anthraquinones were not detected. Upon activation with photodynamic therapy (PDT) treatment, the cell viability decreased. Among the extracts, the hexane crude extract exhibited the highest photocytotoxic activity against the A431 cell line, with an IC50 value of 6.06 ± 0.21 µg/mL, followed by the ethanolic crude extract (IC50 = 8.83 ± 0.55 µg/mL) and the ethyl acetate crude extract (IC50 = 9.37 ± 0.71 µg/mL). However, when tested without PDT treatment, none of the three crude extracts exhibited significant activity against the A431 cell line, even at concentrations as high as 200 μg/mL after 24 hours of incubation in the dark. The results of the present study suggest that S. crispa could serve as a valuable source of photosensitizing agents for photodynamic therapy in cancer treatment. | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-pdf.php?idx=J0048-6a2f632 | 26 February 2024 | Phytochemicals Screening and Photocytotoxicity of Strobilanthes crispa (L.) Blume (Acanthaceae) Leaf Extracts | Phytochemicals Screening and Photocytotoxicity of Strobilanthes crispa (L.) Blume (Acanthaceae) Leaf Extracts | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | Vol 26 No 1 (2024): Malaysian Journal of Chemistry |
Anisoptera laevis; Dipterocarpaceae; maceration; supercritical fluid extraction; stilbenoids | https://doi.org/10.55373/mjchem.v26i1.1 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0048-fa3ab7e | [
"Noorazlina Adnan - Universiti Teknologi MARA",
"Muhammad Sulaiman Mohd Johari - Universiti Teknologi MARA",
"Raihana Mohd Yusof - Universiti Teknologi MARA",
"Aisyah Salihah Kamarozaman - Universiti Teknologi MARA",
"Nurul Iman Aminudin - International Islamic University Malaysia",
"Nurul Nadiah Hamidon - Universiti Malaysia Pahang Al-Sultan Abdullah"
] | Maceration is a conventional extraction method that is considered simple and inexpensive but takes a lengthy extraction period. Supercritical fluid extraction (SFE) is among the modern extraction techniques to extract natural chemical components such as flavonoids, essential oils, carotenoids, and fatty acids, and it is a more sustainable alternative to conventional extraction procedures. In this study, the stem bark of Anisoptera laevis was extracted using SFE and maceration techniques. Stilbenoids are a class of polyphenolic compounds that are rich in bioactivities. It is a secondary metabolite that plays an important role as a defensive mechanism in plants. This research aimed to extract stilbenoids from the stem bark of A. laevis using maceration and SFE techniques and compare the extraction of stilbenoids using both approaches. The LOTUS and MassBank of North America (MoNA) databases identified seventy peaks from each maceration and SFE crude extract with MS/MS values. In maceration and SFE crude extracts, nine stilbenoids were found, with two more peaks detected in maceration crude extract. The results for both extraction procedures are almost comparable, implying that SFE could be considered an option for the greener extraction method with a shorter period. | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-pdf.php?idx=J0048-fa3ab7e | 26 February 2024 | Comparative Study on Different Extraction Methods for Stilbenoids: Maceration and Supercritical Fluid Extraction (SFE) of Anisoptera laevis Ridl. | Comparative Study on Different Extraction Methods for Stilbenoids: Maceration and Supercritical Fluid Extraction (SFE) of Anisoptera laevis Ridl. | https://ikm.org.my/publications/malaysian-journal-of-chemistry/abstract-listing.php?jid=J0048 | Vol 26 No 1 (2024): Malaysian Journal of Chemistry |