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more frequent monitoring for adverse events including opioid use disorder and overdose
267
353
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in a dose-dependent manner
416
442
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a range of 20-50 mg morphine equivalent daily dose
501
551
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over 90 mg morphine equivalent daily dose
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668
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evaluate for tapering to reduced dose or to discontinuation
835
894
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There is moderate quality evidence from retrospective cohort and retrospective case-control studies
0
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a daily dosage range of 20 to <50 mg MEDD
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a range of 50 to <100 mg MEDD compared to risk at <20 mg MEDD
396
457
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approximately 1.5 times
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approximately 2.6 times
368
391
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Prescribed opioid dosage
295
319
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In a prospective cohort study (not included in the evidence review as it did not include information on acute versus chronic pain in the patient population), Dasgupta et al. (2015) compared residents of North Carolina who had received an opioid prescription in the last year to residents who had not.
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Achieving an improved understanding of the factors contributing to prescription opioid-related overdose
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progressively higher doses of prescribed opioids result in correspondingly higher risks of opioid overdose
202
308
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Recognizing the lack of evidence of long-term benefit associated with LOT used alone and the risks of harms with use of opioids without risk mitigation, dosing determinations
0
175
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patients who require higher doses of opioids, even in those who benefit from such therapy
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patients who require higher doses of opioids, even in those who benefit from such therapy
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healthcare resources and patient adherence should be considered
626
689
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104
141
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4.75, 5.47, 6.44, and 7.06, compared to those taking an opioid at the same dosage level without a diagnosis of depression
361
482
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a history of or active SUD
499
525
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Concurrent prescribing of sedative-hypnotics and benzodiazepines
984
1,049
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the impact of systematic reductions in MEDD in terms of pain relief, specific pain and medical conditions, overdose morbidity and mortality as well as potential adverse outcomes (e.g., the incidence of associated OUD, infectious diseases related to intravenous drug use disorder, and drug-related crime and diversion) and to determine whether/which conditions may be appropriately treated with LOT
63
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Long-acting opioids
0
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any specific opioid or opioid formulation, specifically the following: Short-acting versus long-acting opioids (for LOT for chronic pain), Route of administration/delivery among alternatives such as transdermal, buccal, sublingual, or pumps, Abuse deterrent formulations of opioids compared to non-abuse deterrent formulations, Tramadol and other dual-mechanism opioids. Buprenorphine for pain (compared to other opioids), Methadone (with QT monitoring).
60
517
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oxycodone/acetaminophen extended release [ER] tablets
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non-inferior
9
21
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358
394
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369
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Transdermal fentanyl should not be used in opioid-naïve patients; Patients need to be informed that: Heat (e.g., sun exposure, heating pad, febrile condition) can increase the rate and quantity of absorption, Proper application includes: being sure to take old patch off; never applying damaged patch or a patch to non-intact skin; proper disposal to avoid exposure to children and pets, and precautions taken against possible diversion of remaining drug in used patch; Adjusted dose (i.e., decreased patch size) should be used in patients with renal or hepatic insufficiency and considered in elderly patients and those with febrile illness
413
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to present a physical barrier to prevent chewing, crushing, cutting, grating, or grinding of the dosage form, or present a chemical barrier, such as a gelling agent, that will resist extraction of the opioid with use of a common solvent
89
327
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an opioid antagonist (naloxone or naltrexone)
344
390
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consumption of a large number of intact capsules or tablets
652
712
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Future research
0
15
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Future research
0
15
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alternatives to opioids
13
36
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use of multimodal pain care including non-opioid medications as indicated
95
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immediate-release opioids are used at the lowest effective dose with opioid therapy reassessment no later than 3-5 days to determine if adjustments or continuing opioid therapy is indicated
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Patient education about opioid risks and alternatives to opioid therapy
486
557
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116
124
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a history of depression, SUD, catastrophizing, higher preoperative total body pain, history of back pain, and preoperative use of sedative-hypnotics or antidepressants
309
478
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the use of opioids for acute pain
43
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high prescribed dose, history of SUD, and history of mental health concerns
160
236
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patient education, use of non-opioid adjunctive therapy, and structured reassessment of opioid risks and benefits for all on acute OT. Also, consider checking the PDMP and performing a UDT.
260
452
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checking the PDMP, performing a UDT, placement in an inpatient setting or monitored environment, and/or providing OEND
178
297
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the setting, specifics of the painful insult, patient medical factors, and selected medication potency/dose/route of administration/adjunct selection
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VA and DoD healthcare practitioners including physicians, nurse practitioners, physician assistants, physical and occupational therapists, psychologists, social workers, nurses, clinical pharmacists, chaplains, addiction counselors, and others involved in the care of Service Members and their beneficiaries, retirees and their beneficiaries, or Veterans on or being considered for LOT
209
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As with other CPGs, there are limitations, including significant evidence gaps. Further, there is a need to develop effective strategies for guideline implementation and evaluation of the effect of guideline adherence on clinical outcomes.
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on the basis of all clinical data available for an individual patient and are subject to change as scientific knowledge and technology advance and patterns evolve
407
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evidence available by December 2016
594
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the use of a CPG must always be considered as a recommendation, within the context of a provider’s clinical judgment and patient values and preferences, for the care of an individual patient
745
936
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assist healthcare providers in managing or co-managing patients on or being considered for LOT
27
122
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adults, including Veterans as well as deployed and non-deployed Active Duty Service Members, their beneficiaries, and retirees and their beneficiaries, with chronic pain who are receiving care from the VA or DoD healthcare delivery systems
163
404
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does not provide recommendations for the management of pain with LOT in children or adolescents, in patients with acute pain, or in patients receiving end-of-life care
440
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in order to build trust and facilitate frank discussions relating to the social, economic, emotional, and cultural factors that influence patients’ perceptions, behaviors, and decision making
566
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Because a comprehensive review of the evidence related to LOT was not feasible
351
429
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to focus on the use of opioids for chronic pain rather than being comprehensive about all treatment options
305
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the multidisciplinary stakeholder involvement from its inception, ensuring representation from the broad spectrum of clinicians engaged in the treatment and management of patients with chronic pain on or being considered for LOT
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balancing desired outcomes with potential harms of treatment, equity of resource availability, the potential for variation in patient values and preferences, and other considerations
113
296
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the VA/DoD Guideline for Guidelines,[1] an internal document of the VA and DoD EBPWG
193
278
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information regarding the process of developing guidelines, including the identification and assembly of the Guideline Champions (“Champions”) and other subject matter experts from within the VA and DoD, known as the “Work Group,” and ultimately, the development and submission of an updated OT CPG
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to use a patient-centered care approach that is tailored to the patient’s capabilities, needs, goals, prior treatment experience, and preferences
33
179
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decrease patient anxiety, increase trust in clinicians,[77] and improve treatment adherence
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Improved patient-clinician communication through patient-centered care
478
549
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review the patient’s history including previous treatment approaches, their results, and any other outcomes with the patient
65
189
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the foundation of a patient-centered assessment of risks and benefits and a clinical synthesis performed by the provider
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a patient-centered interview, and exploration of patient values, goals, questions, concerns, and expectations
263
373
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the Opioid Therapy Risk Report (OTRR) and the Stratification Tool for Opioid Risk Mitigation (STORM)
140
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allows VA providers to review clinical data related to opioid pain treatment within the electronic medical record (EMR), providing an efficient way of monitoring the data
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incorporates co-occurring medical and mental health conditions, SUD, opioid dose, co-prescribed sedatives, and information about prior adverse events and generates estimates of patients’ risk or hypothetical risk when considering initiation of opioid therapy. It quantifies risk for poisoning or suicide-related events and for drug-related events, accidents, falls, and drug-induced conditions over a three-year window. Further, it provides suggestions as to what alternative treatments have not been tried and what risk mitigation strategies need to be applied.
441
1,008