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Recommendations | 772 | What must be determined through individual clinical assessment? | There may be some situations where the benefits of LOT clearly outweigh the risks. | 217 | Similar to other risk factors, continuing OT beyond 90 days’ duration should be weighed heavily in the risk benefit calculus for LOT. Continuing OT for longer than 90 days is not an absolute contraindication to LOT. There may be some situations where the benefits of LOT clearly outweigh the risks. That must be determined through individual clinical assessment. | [
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Recommendations | 773 | How to determine the situations where the benefits of LOT clearly outweigh the risks? | through individual clinical assessment | 325 | Similar to other risk factors, continuing OT beyond 90 days’ duration should be weighed heavily in the risk benefit calculus for LOT. Continuing OT for longer than 90 days is not an absolute contraindication to LOT. There may be some situations where the benefits of LOT clearly outweigh the risks. That must be determined through individual clinical assessment. | [
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Recommendations | 870 | What kind of rationale is there to explain the the relationship between age and OUD and overdose? | good neurophysiologic rationale | 155 | Some may interpret the recommendation to limit opioid use by age as arbitrary and potentially discriminatory when taken out of context; however, there is good neurophysiologic rationale explaining the relationship between age and OUD and overdose. Studies in other areas (e.g., use of different substances) indicate that developing brains (age <30 years) are at increased risk of abnormalities and addiction when exposed to substance use early in life.[95-98] | [
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Recommendations | 872 | What are at increased risk of abnormalities and addiction when exposed to substance use early in life? | developing brains (age <30 years) | 324 | Some may interpret the recommendation to limit opioid use by age as arbitrary and potentially discriminatory when taken out of context; however, there is good neurophysiologic rationale explaining the relationship between age and OUD and overdose. Studies in other areas (e.g., use of different substances) indicate that developing brains (age <30 years) are at increased risk of abnormalities and addiction when exposed to substance use early in life.[95-98] | [
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Recommendations | 873 | What are the risks of substance use early in life? | increased risk of abnormalities and addiction | 365 | Some may interpret the recommendation to limit opioid use by age as arbitrary and potentially discriminatory when taken out of context; however, there is good neurophysiologic rationale explaining the relationship between age and OUD and overdose. Studies in other areas (e.g., use of different substances) indicate that developing brains (age <30 years) are at increased risk of abnormalities and addiction when exposed to substance use early in life.[95-98] | [
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Recommendations | 1,051 | What is included in the dual-mechanism opioids? | formulations of an opioid medication with a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI) | 55 | Dual-Mechanism Opioids: Dual-mechanism opioids include formulations of an opioid medication with a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI). Two common examples are tramadol and tapentadol. While both are dual-mechanism opioids, they differ in their affinity for the mu opioid receptor, resulting in partial versus full agonist effects, and as such are discussed separately. | [
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Recommendations | 1,052 | What are the examples of dual-mechanism opioids? | tramadol and tapentadol | 228 | Dual-Mechanism Opioids: Dual-mechanism opioids include formulations of an opioid medication with a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI). Two common examples are tramadol and tapentadol. While both are dual-mechanism opioids, they differ in their affinity for the mu opioid receptor, resulting in partial versus full agonist effects, and as such are discussed separately. | [
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Recommendations | 1,053 | What are the differences between tramadol and tapentadol? | While both are dual-mechanism opioids, they differ in their affinity for the mu opioid receptor, resulting in partial versus full agonist effects | 253 | Dual-Mechanism Opioids: Dual-mechanism opioids include formulations of an opioid medication with a selective serotonin reuptake inhibitor (SSRI) or a serotonin-norepinephrine reuptake inhibitor (SNRI). Two common examples are tramadol and tapentadol. While both are dual-mechanism opioids, they differ in their affinity for the mu opioid receptor, resulting in partial versus full agonist effects, and as such are discussed separately. | [
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] | While both are dual-mechanism opioids, they differ in their affinity for the mu opioid receptor, resulting in partial versus full agonist effects | 253 | 399 |