Unnamed: 0.2
int64
0
15.9k
Unnamed: 0
int64
0
16.7k
Unnamed: 0.1
int64
262
24.9k
Name
stringlengths
2
19
Ab or Nb
stringclasses
1 value
Binds to
stringclasses
31 values
IS_bind_two
int64
0
1
IS_bind_three
int64
0
2
Protein + Epitope
stringclasses
2 values
Origin
stringclasses
100 values
VHorVHH
stringlengths
107
139
VL
stringlengths
92
122
Heavy V Gene
stringclasses
113 values
Heavy J Gene
stringclasses
16 values
Light V Gene
stringclasses
120 values
Light J Gene
stringclasses
23 values
CDRH3
stringlengths
5
31
CDRL3
stringlengths
4
18
Structures
stringclasses
333 values
ABB Homology Model (if no structure)
null
Sources
stringclasses
346 values
Date Added
stringclasses
69 values
Last Updated
stringclasses
58 values
Update Description
nullclasses
262 values
Notes/Following Up?
stringclasses
177 values
Epitope_seq
stringclasses
42 values
VH_secondstructure
stringlengths
125
165
VL_secondstructure
stringlengths
106
140
Epitope_PyProtein
stringclasses
42 values
H_region_index_AbRSAIMGT
stringclasses
253 values
L_region_index_AbRSAIMGT
stringclasses
198 values
0
0
262
XK01
Ab
SARS-CoV2_WT
1
2
S; RBD
Phage Display (Ab, human, immune - SARS-CoV2)
EVQLLESGTEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPILGIANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERGYSGYGAAYYFDYWGQGTLVTVSS
QSVLTQAPSVSGAPGQSVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSKGVFGGGTKLTVL
IGHV1-69 (Human)
IGHJ4 (Human)
IGLV1-40 (Human)
IGLJ2 (Human)
ARERGYSGYGAAYYFDY
QSYDSSLSKGV
ND
null
Qianqian Zheng et al., 2022 (https://www.sciencedirect.com/science/article/pii/S2352304222001623)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
E VQLLE SGT EVK KPGS SVKVSCK ASGGT FSSYAISWVR QAPGQGL EWM GG II P I LGIANYAQK FQG RVTITA DKSTS TAYMELS SLRSEDT AVYYCA R ERGYSGYG AAYYFD YWGQG TLVTVS S
QS VLT QAPSVSGAPGQ SVTISCT GSSSNIGAG YDVHWYQ QLPGTAP KLLIYG NNNRPSGVPDRFSGSKSGTS ASLAIT GLQAEDEAD YYCQS YDSSLSKGVFGGGT KLTV L
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.302, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.256, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 53.363, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 47.534, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 53.363, '_NormalizedVDWVC2': 0.35, '_PolarizabilityC2': 0.448, '_PolarizabilityC3': 0.256, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 47.534, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.386, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 47.534, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 44.395, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 69.507, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.144, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.072, '_ChargeC2': 0.825, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 23.318, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 51.121, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.287, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.185, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.248, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 69.507, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.032, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.265, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.381, '_PolarityC3': 0.108, '_PolarityC2': 0.215}
25,33,50,58,96,113,124
25,34,51,54,90,101,111
1
1
263
XK01
Ab
SARS-CoV2_Omicron-BA1
1
2
S; RBD
Phage Display (Ab, human, immune - SARS-CoV2)
EVQLLESGTEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMGGIIPILGIANYAQKFQGRVTITADKSTSTAYMELSSLRSEDTAVYYCARERGYSGYGAAYYFDYWGQGTLVTVSS
QSVLTQAPSVSGAPGQSVTISCTGSSSNIGAGYDVHWYQQLPGTAPKLLIYGNNNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSKGVFGGGTKLTVL
IGHV1-69 (Human)
IGHJ4 (Human)
IGLV1-40 (Human)
IGLJ2 (Human)
ARERGYSGYGAAYYFDY
QSYDSSLSKGV
ND
null
Qianqian Zheng et al., 2022 (https://www.sciencedirect.com/science/article/pii/S2352304222001623)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
E VQLLE SGT EVK KPGS SVKVSCK ASGGT FSSYAISWVR QAPGQGL EWM GG II P I LGIANYAQK FQG RVTITA DKSTS TAYMELS SLRSEDT AVYYCA R ERGYSGYG AAYYFD YWGQG TLVTVS S
QS VLT QAPSVSGAPGQ SVTISCT GSSSNIGAG YDVHWYQ QLPGTAP KLLIYG NNNRPSGVPDRFSGSKSGTS ASLAIT GLQAEDEAD YYCQS YDSSLSKGVFGGGT KLTV L
{'_NormalizedVDWVD1075': 73.543, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 29.148, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.284, '_PolarityD3025': 26.906, '_NormalizedVDWVC1': 0.341, '_NormalizedVDWVC3': 0.278, '_HydrophobicityT23': 0.234, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.189, '_PolarityT13': 0.113, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 48.43, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 22.422, '_PolarizabilityD3025': 25.112, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 60.987, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 25.112, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 47.982, '_NormalizedVDWVC2': 0.341, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.278, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.278, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.323, '_ChargeT12': 0.185, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.709, '_SecondaryStrD1025': 23.767, '_SolventAccessibilityD1050': 47.982, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 72.197, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.673, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.305, '_HydrophobicityC2': 0.372, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 26.009, '_NormalizedVDWVT13': 0.194, '_PolarizabilityD3050': 54.709, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.284, '_PolarityD1050': 47.982, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.323, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 54.709, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 48.43, '_PolarizabilityD1050': 45.74, '_SolventAccessibilityT23': 0.18, '_ChargeC3': 0.072, '_ChargeC2': 0.812, '_ChargeC1': 0.117, '_NormalizedVDWVT23': 0.207, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 78.924, '_HydrophobicityD2075': 77.578, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.224, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.3, '_ChargeD3025': 20.628, '_PolarityD3001': 0.448, '_PolarityD3075': 80.717, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.234, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 74.888, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.23, '_HydrophobicityT12': 0.234, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 26.009, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.221, '_PolarizabilityT23': 0.275, '_SolventAccessibilityD3050': 53.812, '_PolarityT23': 0.054, '_PolarityD2050': 48.43, '_HydrophobicityD2025': 26.009, '_PolarizabilityD2075': 75.785, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.305, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.094, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.39, '_PolarityC3': 0.126, '_PolarityC2': 0.206}
25,33,50,58,96,113,124
25,34,51,54,90,101,111
2
2
264
XK02
Ab
SARS-CoV2_WT
1
2
S; RBD
Phage Display (Ab, human, immune - SARS-CoV2)
EVQLLESGPGLVKPSETLSLTCTVSGGSISNSSYYWGWIRQPPGKGLEWIGSIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTGVYYCASWLYGDPISFDYWGQGTLVTVSS
DIELTQSPSSLSASVGDRVTITCRASQSISSYLNWYRQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTRVEVK
IGHV4-39 (Human)
IGHJ4 (Human)
IGKV1-39 (Human)
IGKJ4 (Human)
ASWLYGDPISFDY
QQSYSTPLT
ND
null
Qianqian Zheng et al., 2022 (https://www.sciencedirect.com/science/article/pii/S2352304222001623)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
E VQLLE SGPGL V KPSE TLSLTCTV SGGSISNSS YYWGWIR QPPGKGL EWIGSIYYS GS TY YNPSLKS RVTISVD TSKN QFSLKLSSVT AADTG VYYCASWL YGDPI SFDY WGQG TLVTVS S
DI ELT QSPSS LSA SVGD RVTITCR ASQS ISSYLNWYR QKPGKAP KLLIYAA SSLQSGVPS R FSGSGSGTD FTLTIS SLQP EDFAT YYCQ QSYSTPL TF GGG TRVEV K
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.302, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.256, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 53.363, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 47.534, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 53.363, '_NormalizedVDWVC2': 0.35, '_PolarizabilityC2': 0.448, '_PolarizabilityC3': 0.256, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 47.534, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.386, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 47.534, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 44.395, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 69.507, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.144, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.072, '_ChargeC2': 0.825, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 23.318, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 51.121, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.287, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.185, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.248, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 69.507, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.032, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.265, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.381, '_PolarityC3': 0.108, '_PolarityC2': 0.215}
25,35,52,59,97,110,121
26,32,49,52,88,97,107
3
3
265
XK02
Ab
SARS-CoV2_Omicron-BA1
1
2
S; RBD
Phage Display (Ab, human, immune - SARS-CoV2)
EVQLLESGPGLVKPSETLSLTCTVSGGSISNSSYYWGWIRQPPGKGLEWIGSIYYSGSTYYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTGVYYCASWLYGDPISFDYWGQGTLVTVSS
DIELTQSPSSLSASVGDRVTITCRASQSISSYLNWYRQKPGKAPKLLIYAASSLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYSTPLTFGGGTRVEVK
IGHV4-39 (Human)
IGHJ4 (Human)
IGKV1-39 (Human)
IGKJ4 (Human)
ASWLYGDPISFDY
QQSYSTPLT
ND
null
Qianqian Zheng et al., 2022 (https://www.sciencedirect.com/science/article/pii/S2352304222001623)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
E VQLLE SGPGL V KPSE TLSLTCTV SGGSISNSS YYWGWIR QPPGKGL EWIGSIYYS GS TY YNPSLKS RVTISVD TSKN QFSLKLSSVT AADTG VYYCASWL YGDPI SFDY WGQG TLVTVS S
DI ELT QSPSS LSA SVGD RVTITCR ASQS ISSYLNWYR QKPGKAP KLLIYAA SSLQSGVPS R FSGSGSGTD FTLTIS SLQP EDFAT YYCQ QSYSTPL TF GGG TRVEV K
{'_NormalizedVDWVD1075': 73.543, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 29.148, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.284, '_PolarityD3025': 26.906, '_NormalizedVDWVC1': 0.341, '_NormalizedVDWVC3': 0.278, '_HydrophobicityT23': 0.234, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.189, '_PolarityT13': 0.113, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 48.43, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 22.422, '_PolarizabilityD3025': 25.112, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 60.987, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 25.112, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 47.982, '_NormalizedVDWVC2': 0.341, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.278, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.278, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.323, '_ChargeT12': 0.185, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.709, '_SecondaryStrD1025': 23.767, '_SolventAccessibilityD1050': 47.982, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 72.197, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.673, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.305, '_HydrophobicityC2': 0.372, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 26.009, '_NormalizedVDWVT13': 0.194, '_PolarizabilityD3050': 54.709, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.284, '_PolarityD1050': 47.982, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.323, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 54.709, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 48.43, '_PolarizabilityD1050': 45.74, '_SolventAccessibilityT23': 0.18, '_ChargeC3': 0.072, '_ChargeC2': 0.812, '_ChargeC1': 0.117, '_NormalizedVDWVT23': 0.207, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 78.924, '_HydrophobicityD2075': 77.578, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.224, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.3, '_ChargeD3025': 20.628, '_PolarityD3001': 0.448, '_PolarityD3075': 80.717, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.234, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 74.888, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.23, '_HydrophobicityT12': 0.234, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 26.009, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.221, '_PolarizabilityT23': 0.275, '_SolventAccessibilityD3050': 53.812, '_PolarityT23': 0.054, '_PolarityD2050': 48.43, '_HydrophobicityD2025': 26.009, '_PolarizabilityD2075': 75.785, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.305, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.094, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.39, '_PolarityC3': 0.126, '_PolarityC2': 0.206}
25,35,52,59,97,110,121
26,32,49,52,88,97,107
4
4
296
M8a-3
Ab
SARS-CoV2_WT
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.302, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.256, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 53.363, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 47.534, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 53.363, '_NormalizedVDWVC2': 0.35, '_PolarizabilityC2': 0.448, '_PolarizabilityC3': 0.256, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 47.534, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.386, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 47.534, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 44.395, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 69.507, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.144, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.072, '_ChargeC2': 0.825, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 23.318, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 51.121, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.287, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.185, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.248, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 69.507, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.032, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.265, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.381, '_PolarityC3': 0.108, '_PolarityC2': 0.215}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
5
5
297
M8a-3
Ab
SARS-CoV2_Beta
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVKGFNCYFPLQSYGFQPTYGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.682, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.306, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.26, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 66.368, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 51.57, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 49.327, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 76.233, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 51.57, '_NormalizedVDWVC2': 0.345, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.26, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.381, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 52.915, '_SecondaryStrD1025': 22.422, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 75.785, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.296, '_HydrophobicityC2': 0.39, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.185, '_PolarizabilityD3050': 52.915, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.284, '_PolarityD1050': 51.121, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 47.534, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 75.336, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.153, '_PolarizabilityT12': 0.252, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.18, '_ChargeC3': 0.067, '_ChargeC2': 0.83, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 77.578, '_HydrophobicityD2075': 76.682, '_HydrophobicityD1075': 66.816, '_ChargeD2050': 50.673, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.283, '_ChargeD3025': 20.628, '_PolarityD3001': 0.448, '_PolarityD3075': 74.439, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.18, '_SecondaryStrT12': 0.239, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.239, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 75.336, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 66.816, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 72.197, '_NormalizedVDWVT12': 0.221, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 50.224, '_PolarityT23': 0.032, '_PolarityD2050': 53.363, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 77.578, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.296, '_SolventAccessibilityC3': 0.269, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.991, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.386, '_PolarityC3': 0.108, '_PolarityC2': 0.211}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
6
6
298
M8a-3
Ab
SARS-CoV2_Delta
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 71.3, '_PolarityD1075': 76.682, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.293, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.35, '_NormalizedVDWVC3': 0.265, '_HydrophobicityT23': 0.221, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 26.906, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.198, '_PolarityT13': 0.113, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 74.439, '_PolarizabilityD2050': 52.018, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 68.161, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 49.327, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 52.018, '_NormalizedVDWVC2': 0.345, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.265, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.291, '_SecondaryStrC2': 0.372, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.176, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 49.776, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.215, '_HydrophobicityD2050': 48.43, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.309, '_HydrophobicityC2': 0.381, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.185, '_PolarizabilityD3050': 49.776, '_SolventAccessibilityT13': 0.23, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.309, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.076, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 26.906, '_ChargeD1050': 47.534, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 71.749, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 43.946, '_SolventAccessibilityT23': 0.203, '_ChargeC3': 0.072, '_ChargeC2': 0.816, '_ChargeC1': 0.112, '_NormalizedVDWVT23': 0.189, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.673, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.291, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 76.233, '_HydrophobicityD1050': 49.327, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.266, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 71.749, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.248, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.036, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.43, '_SolventAccessibilityC2': 0.309, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.377, '_PolarityC3': 0.117, '_PolarityC2': 0.215}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
7
7
299
M8a-3
Ab
SARS-CoV2_Omicron-BA1
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 73.543, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 29.148, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.284, '_PolarityD3025': 26.906, '_NormalizedVDWVC1': 0.341, '_NormalizedVDWVC3': 0.278, '_HydrophobicityT23': 0.234, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.189, '_PolarityT13': 0.113, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 48.43, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 22.422, '_PolarizabilityD3025': 25.112, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 60.987, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 25.112, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 47.982, '_NormalizedVDWVC2': 0.341, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.278, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.278, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.323, '_ChargeT12': 0.185, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.709, '_SecondaryStrD1025': 23.767, '_SolventAccessibilityD1050': 47.982, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 72.197, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.673, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.305, '_HydrophobicityC2': 0.372, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 26.009, '_NormalizedVDWVT13': 0.194, '_PolarizabilityD3050': 54.709, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.284, '_PolarityD1050': 47.982, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.323, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 54.709, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 48.43, '_PolarizabilityD1050': 45.74, '_SolventAccessibilityT23': 0.18, '_ChargeC3': 0.072, '_ChargeC2': 0.812, '_ChargeC1': 0.117, '_NormalizedVDWVT23': 0.207, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 78.924, '_HydrophobicityD2075': 77.578, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.224, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.3, '_ChargeD3025': 20.628, '_PolarityD3001': 0.448, '_PolarityD3075': 80.717, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.234, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 74.888, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.23, '_HydrophobicityT12': 0.234, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 26.009, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.221, '_PolarizabilityT23': 0.275, '_SolventAccessibilityD3050': 53.812, '_PolarityT23': 0.054, '_PolarityD2050': 48.43, '_HydrophobicityD2025': 26.009, '_PolarizabilityD2075': 75.785, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.305, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.094, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.39, '_PolarityC3': 0.126, '_PolarityC2': 0.206}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
8
8
300
M8a-3
Ab
SARS-CoV2_Omicron-BA2
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 73.543, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 29.148, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.293, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.341, '_NormalizedVDWVC3': 0.278, '_HydrophobicityT23': 0.239, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 20.628, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.189, '_PolarityT13': 0.108, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 48.43, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 22.422, '_PolarizabilityD3025': 23.767, '_SecondaryStrD3050': 49.327, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 60.987, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 23.767, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 47.982, '_NormalizedVDWVC2': 0.341, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.278, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.278, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.327, '_ChargeT12': 0.176, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.709, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 47.982, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 72.197, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.673, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.377, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 26.009, '_NormalizedVDWVT13': 0.198, '_PolarizabilityD3050': 54.709, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.279, '_PolarityD1050': 47.982, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.323, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 55.157, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 20.628, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.153, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 48.43, '_PolarizabilityD1050': 45.74, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.067, '_ChargeC2': 0.821, '_ChargeC1': 0.112, '_NormalizedVDWVT23': 0.203, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 77.578, '_HydrophobicityD2075': 77.578, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 49.776, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.296, '_ChargeD3025': 9.865, '_PolarityD3001': 0.448, '_PolarityD3075': 80.717, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.239, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 26.009, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 72.197, '_NormalizedVDWVT12': 0.225, '_PolarizabilityT23': 0.27, '_SolventAccessibilityD3050': 50.224, '_PolarityT23': 0.05, '_PolarityD2050': 46.637, '_HydrophobicityD2025': 27.803, '_PolarizabilityD2075': 75.785, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.444, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.256, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.094, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.39, '_PolarityC3': 0.121, '_PolarityC2': 0.211}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
9
9
303
M8a-3
Ab
RatG13
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTDSIVRFPNITNLCPFGEVFNATTFASVYAWNRKRISNCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADSFVITGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSKHIDAKEGGNFNYLYRLFRKANLKPFERDISTEIYQAGSKPCNGQTGLNCYYPLYRYGFYPTDGVGHQPYRVVVLSFELLNAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 71.3, '_PolarityD1075': 77.13, '_SecondaryStrD3025': 24.664, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.297, '_PolarityD3025': 26.906, '_NormalizedVDWVC1': 0.368, '_NormalizedVDWVC3': 0.265, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 25.112, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 26.906, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.185, '_PolarityT13': 0.099, '_ChargeT23': 0.122, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 73.991, '_PolarizabilityD2050': 51.57, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 68.161, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 25.112, '_SecondaryStrD3050': 48.879, '_SolventAccessibilityD2050': 53.363, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 74.439, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 25.112, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 51.57, '_NormalizedVDWVC2': 0.327, '_PolarizabilityC2': 0.426, '_PolarizabilityC3': 0.265, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.309, '_SecondaryStrC2': 0.386, '_SecondaryStrC3': 0.323, '_ChargeT12': 0.162, '_ChargeT13': 0.014, '_ChargeD1001': 0.448, '_ChargeD1025': 26.906, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.26, '_SecondaryStrD1025': 30.942, '_SolventAccessibilityD1050': 50.673, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 75.785, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 23.767, '_HydrophobicityD2050': 48.43, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.296, '_HydrophobicityC2': 0.399, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.215, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 54.26, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.293, '_PolarityD1050': 49.776, '_ChargeD3075': 56.951, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.305, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 56.502, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 43.498, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.076, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 26.906, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.135, '_PolarizabilityT12': 0.243, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.291, '_PolarizabilityD1050': 43.498, '_SolventAccessibilityT23': 0.171, '_ChargeC3': 0.076, '_ChargeC2': 0.816, '_ChargeC1': 0.108, '_NormalizedVDWVT23': 0.189, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 69.955, '_ChargeD2050': 49.776, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.291, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 71.749, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.189, '_SecondaryStrT12': 0.23, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 53.363, '_HydrophobicityT13': 0.207, '_HydrophobicityT12': 0.257, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 24.215, '_SolventAccessibilityD2075': 69.955, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.543, '_NormalizedVDWVT12': 0.212, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 46.188, '_PolarityT23': 0.045, '_PolarityD2050': 56.951, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 77.578, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.43, '_SolventAccessibilityC2': 0.296, '_SolventAccessibilityC3': 0.274, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.336, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.377, '_PolarityC3': 0.117, '_PolarityC2': 0.197}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
10
10
304
M8a-3
Ab
SARS-CoV1
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVVPSGDVVRFPNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNF
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 73.423, '_PolarityD1075': 77.027, '_SecondaryStrD3025': 25.676, '_PolarityD3100': 97.297, '_ChargeD1100': 97.297, '_SecondaryStrT23': 0.312, '_PolarityD3025': 17.117, '_NormalizedVDWVC1': 0.383, '_NormalizedVDWVC3': 0.261, '_HydrophobicityT23': 0.24, '_SolventAccessibilityD1025': 22.523, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.55, '_ChargeD3050': 45.946, '_PolarityD2001': 1.802, '_SolventAccessibilityD2025': 23.423, '_HydrophobicityD3050': 45.045, '_PolarityT12': 0.19, '_PolarityT13': 0.104, '_ChargeT23': 0.131, '_HydrophobicityD2100': 95.495, '_SolventAccessibilityD3001': 1.802, '_ChargeD1075': 63.964, '_SecondaryStrD1075': 74.775, '_PolarizabilityD2050': 51.802, '_SolventAccessibilityD3100': 95.495, '_PolarizabilityD1075': 71.171, '_HydrophobicityD3025': 22.072, '_PolarizabilityD3025': 22.973, '_SecondaryStrD3050': 49.55, '_SolventAccessibilityD2050': 49.099, '_HydrophobicityD2001': 1.802, '_SecondaryStrD2075': 76.577, '_PolarityD3050': 47.748, '_PolarityD1001': 0.901, '_ChargeD2075': 76.577, '_NormalizedVDWVD3025': 22.973, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.198, '_NormalizedVDWVD1001': 1.802, '_NormalizedVDWVD2050': 48.198, '_NormalizedVDWVC2': 0.315, '_PolarizabilityC2': 0.428, '_PolarizabilityC3': 0.261, '_NormalizedVDWVD3001': 0.45, '_PolarizabilityC1': 0.311, '_SecondaryStrC2': 0.392, '_SecondaryStrC3': 0.342, '_ChargeT12': 0.163, '_ChargeT13': 0.014, '_ChargeD1001': 0.45, '_ChargeD1025': 17.117, '_NormalizedVDWVD2025': 22.072, '_NormalizedVDWVD3050': 50.0, '_SecondaryStrD1025': 27.027, '_SolventAccessibilityD1050': 45.045, '_PolarizabilityD3001': 0.45, '_PolarityD2075': 75.676, '_SecondaryStrD3001': 1.802, '_ChargeD2025': 24.775, '_HydrophobicityD2050': 54.054, '_PolarizabilityD1100': 95.946, '_HydrophobicityC1': 0.279, '_HydrophobicityC2': 0.396, '_SolventAccessibilityD2100': 99.55, '_PolarizabilityD2001': 0.901, '_PolarizabilityD1025': 26.126, '_NormalizedVDWVT13': 0.186, '_PolarizabilityD3050': 50.0, '_SolventAccessibilityT13': 0.271, '_SolventAccessibilityT12': 0.276, '_PolarityD1050': 48.198, '_ChargeD3075': 66.216, '_SolventAccessibilityD1001': 0.901, '_HydrophobicityC3': 0.324, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.252, '_ChargeD3001': 3.153, '_SecondaryStrD2050': 45.045, '_PolarityD2025': 18.919, '_NormalizedVDWVD2001': 0.901, '_HydrophobicityD3075': 77.027, '_SecondaryStrD2025': 22.072, '_SolventAccessibilityD2001': 0.45, '_HydrophobicityD1025': 23.423, '_ChargeD1050': 47.748, '_SolventAccessibilityD3025': 24.324, '_PolarizabilityD3075': 65.766, '_PolarityD2100': 99.55, '_SecondaryStrD3100': 99.55, '_PolarizabilityT13': 0.14, '_PolarizabilityT12': 0.24, '_SecondaryStrD2001': 0.901, '_NormalizedVDWVD1050': 49.099, '_PolarizabilityD1050': 45.495, '_SolventAccessibilityT23': 0.163, '_ChargeC3': 0.081, '_ChargeC2': 0.82, '_ChargeC1': 0.099, '_NormalizedVDWVT23': 0.167, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.072, '_SolventAccessibilityD3075': 74.324, '_HydrophobicityD2075': 74.775, '_HydrophobicityD1075': 67.117, '_ChargeD2050': 50.901, '_ChargeD3100': 95.946, '_SecondaryStrC1': 0.266, '_ChargeD3025': 20.721, '_PolarityD3001': 0.45, '_PolarityD3075': 63.964, '_PolarityD1025': 22.973, '_SecondaryStrT13': 0.167, '_SecondaryStrT12': 0.217, '_HydrophobicityD1001': 0.45, '_SolventAccessibilityD1075': 76.126, '_HydrophobicityD1050': 49.099, '_HydrophobicityT13': 0.208, '_HydrophobicityT12': 0.231, '_SecondaryStrD1001': 0.45, '_NormalizedVDWVD1100': 95.946, '_NormalizedVDWVD3075': 65.766, '_NormalizedVDWVD1025': 26.126, '_SolventAccessibilityD2075': 67.117, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 72.523, '_NormalizedVDWVT12': 0.199, '_PolarizabilityT23': 0.231, '_SolventAccessibilityD3050': 56.757, '_PolarityT23': 0.036, '_PolarityD2050': 58.559, '_HydrophobicityD2025': 26.126, '_PolarizabilityD2075': 77.928, '_HydrophobicityD3001': 0.901, '_HydrophobicityD1100': 99.55, '_ChargeD2001': 0.901, '_SolventAccessibilityC1': 0.437, '_SolventAccessibilityC2': 0.279, '_SolventAccessibilityC3': 0.284, '_PolarizabilityD1001': 2.252, '_NormalizedVDWVD2075': 78.378, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.55, '_PolarityC1': 0.396, '_PolarityC3': 0.104, '_PolarityC2': 0.189}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
11
11
305
M8a-3
Ab
WIV1
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVAPSKEVVRFPNITNLCPFGEVFNATTFPSVYAWERKRISNCVADYSVLYNSTSFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFTGCVLAWNTRNIDATQTGNYNYKYRSLRHGKLRPFERDISNVPFSPDGKPCTPPAFNCYWPLNDYGFYITNGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNF
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 71.622, '_PolarityD1075': 77.928, '_SecondaryStrD3025': 28.378, '_PolarityD3100': 97.297, '_ChargeD1100': 97.297, '_SecondaryStrT23': 0.312, '_PolarityD3025': 17.117, '_NormalizedVDWVC1': 0.383, '_NormalizedVDWVC3': 0.252, '_HydrophobicityT23': 0.253, '_SolventAccessibilityD1025': 25.225, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.55, '_ChargeD3050': 45.946, '_PolarityD2001': 1.802, '_SolventAccessibilityD2025': 27.027, '_HydrophobicityD3050': 48.198, '_PolarityT12': 0.19, '_PolarityT13': 0.095, '_ChargeT23': 0.127, '_HydrophobicityD2100': 95.495, '_SolventAccessibilityD3001': 1.802, '_ChargeD1075': 63.964, '_SecondaryStrD1075': 72.072, '_PolarizabilityD2050': 52.252, '_SolventAccessibilityD3100': 95.495, '_PolarizabilityD1075': 68.018, '_HydrophobicityD3025': 22.072, '_PolarizabilityD3025': 22.973, '_SecondaryStrD3050': 50.901, '_SolventAccessibilityD2050': 49.55, '_HydrophobicityD2001': 1.351, '_SecondaryStrD2075': 76.126, '_PolarityD3050': 47.748, '_PolarityD1001': 0.901, '_ChargeD2075': 76.577, '_NormalizedVDWVD3025': 22.973, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.198, '_NormalizedVDWVD1001': 1.351, '_NormalizedVDWVD2050': 51.802, '_NormalizedVDWVC2': 0.324, '_PolarizabilityC2': 0.437, '_PolarizabilityC3': 0.252, '_NormalizedVDWVD3001': 0.45, '_PolarizabilityC1': 0.311, '_SecondaryStrC2': 0.387, '_SecondaryStrC3': 0.342, '_ChargeT12': 0.158, '_ChargeT13': 0.018, '_ChargeD1001': 0.45, '_ChargeD1025': 17.117, '_NormalizedVDWVD2025': 22.523, '_NormalizedVDWVD3050': 50.0, '_SecondaryStrD1025': 22.523, '_SolventAccessibilityD1050': 48.198, '_PolarizabilityD3001': 0.45, '_PolarityD2075': 75.676, '_SecondaryStrD3001': 1.802, '_ChargeD2025': 24.775, '_HydrophobicityD2050': 50.45, '_PolarizabilityD1100': 95.946, '_HydrophobicityC1': 0.288, '_HydrophobicityC2': 0.396, '_SolventAccessibilityD2100': 99.55, '_PolarizabilityD2001': 0.901, '_PolarizabilityD1025': 25.676, '_NormalizedVDWVT13': 0.195, '_PolarizabilityD3050': 50.0, '_SolventAccessibilityT13': 0.276, '_SolventAccessibilityT12': 0.271, '_PolarityD1050': 48.198, '_ChargeD3075': 66.216, '_SolventAccessibilityD1001': 0.901, '_HydrophobicityC3': 0.315, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.252, '_ChargeD3001': 3.153, '_SecondaryStrD2050': 46.396, '_PolarityD2025': 18.919, '_NormalizedVDWVD2001': 0.901, '_HydrophobicityD3075': 77.928, '_SecondaryStrD2025': 22.072, '_SolventAccessibilityD2001': 0.45, '_HydrophobicityD1025': 27.027, '_ChargeD1050': 47.748, '_SolventAccessibilityD3025': 23.874, '_PolarizabilityD3075': 69.82, '_PolarityD2100': 99.55, '_SecondaryStrD3100': 99.55, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.267, '_SecondaryStrD2001': 0.901, '_NormalizedVDWVD1050': 48.649, '_PolarizabilityD1050': 44.144, '_SolventAccessibilityT23': 0.176, '_ChargeC3': 0.081, '_ChargeC2': 0.82, '_ChargeC1': 0.099, '_NormalizedVDWVT23': 0.176, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.523, '_SolventAccessibilityD3075': 73.423, '_HydrophobicityD2075': 73.874, '_HydrophobicityD1075': 68.468, '_ChargeD2050': 50.901, '_ChargeD3100': 95.946, '_SecondaryStrC1': 0.27, '_ChargeD3025': 20.721, '_PolarityD3001': 0.45, '_PolarityD3075': 63.964, '_PolarityD1025': 22.973, '_SecondaryStrT13': 0.176, '_SecondaryStrT12': 0.217, '_HydrophobicityD1001': 0.45, '_SolventAccessibilityD1075': 77.928, '_HydrophobicityD1050': 49.55, '_HydrophobicityT13': 0.204, '_HydrophobicityT12': 0.244, '_SecondaryStrD1001': 0.45, '_NormalizedVDWVD1100': 95.946, '_NormalizedVDWVD3075': 69.82, '_NormalizedVDWVD1025': 25.676, '_SolventAccessibilityD2075': 68.468, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.874, '_NormalizedVDWVT12': 0.217, '_PolarizabilityT23': 0.24, '_SolventAccessibilityD3050': 50.45, '_PolarityT23': 0.041, '_PolarityD2050': 57.207, '_HydrophobicityD2025': 24.775, '_PolarizabilityD2075': 78.378, '_HydrophobicityD3001': 0.901, '_HydrophobicityD1100': 99.55, '_ChargeD2001': 0.901, '_SolventAccessibilityC1': 0.432, '_SolventAccessibilityC2': 0.288, '_SolventAccessibilityC3': 0.279, '_PolarizabilityD1001': 1.351, '_NormalizedVDWVD2075': 81.982, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.55, '_PolarityC1': 0.383, '_PolarityC3': 0.104, '_PolarityC2': 0.203}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
12
12
312
M8a-3
Ab
BtKY72
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVLPGASVKLSCKASGYTFTNYWMHWVKQRPGHGLEWIGEIDPFDTYIKINQKFKGKSTLTVDTSSSTAYMQLSSLTSEDSAVYYCARPDSSGYPVYFDYWGQGTTLTVSS
DIVMTQSHKFMSTSVGDRVSITCKASQDVGTYIAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTNYTLTISSVQAEDLALYHCQQHYSTPYTFGGGTKLEIK
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDSSGYPVYFDY
QQHYSTPYT
Expected (7UZ4)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
MPALLSLVSLLSVLLMGCVARVSPSTEVVRFPNITNLCPFGQVFNASNFPSVYAWERLRISDCVADYAVLYNSSSSFSTFKCYGVSPTKLNDLCFSSVYADYFVVKGDDVRQIAPAQTGVIADYNYKLPDDFTGCVLAWNTNSVDSKSGNNFYYRLFRHGKIKPYERDISNVLYNSAGGTCSSISQLGCYEPLKSYGFTPTVGVGYQPYRVVVLSFELLNAPATVCGPKKSTELVKNKCVNFGGGGSGGGGSHHHHHHHHGGGGSGGGSGGGSGSGRGVPHIVMVDAYKRYK
QV QLQ QPGA ELV LPGA SVKLSCK ASGY TFTNYWMHWVK QRPGHGL EWIGEI DPFDT YIKI NQKFKGK STLTVD TSSST AYMQLS SLTSEDS AVYYCA RPDSSGY PVYFDY WGQG TTLTVS S
D IVMTQ SH KFMS TSVGD RVSITCK ASQDVG TYIAWYQ QKPGQSP KLLIYWA STRHTGVPDR F TGSGSGTN YTLTISSV QAED LALYHCQ QHYSTPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 79.11, '_PolarityD1075': 66.096, '_SecondaryStrD3025': 28.767, '_PolarityD3100': 100.0, '_ChargeD1100': 100.0, '_SecondaryStrT23': 0.251, '_PolarityD3025': 38.014, '_NormalizedVDWVC1': 0.421, '_NormalizedVDWVC3': 0.247, '_HydrophobicityT23': 0.237, '_SolventAccessibilityD1025': 21.918, '_PolarityD1100': 99.658, '_NormalizedVDWVD2100': 97.603, '_ChargeD3050': 42.123, '_PolarityD2001': 0.685, '_SolventAccessibilityD2025': 30.479, '_HydrophobicityD3050': 35.959, '_PolarityT12': 0.124, '_PolarityT13': 0.093, '_ChargeT23': 0.1, '_HydrophobicityD2100': 99.658, '_SolventAccessibilityD3001': 0.342, '_ChargeD1075': 78.425, '_SecondaryStrD1075': 75.685, '_PolarizabilityD2050': 42.808, '_SolventAccessibilityD3100': 99.658, '_PolarizabilityD1075': 83.562, '_HydrophobicityD3025': 14.726, '_PolarizabilityD3025': 28.425, '_SecondaryStrD3050': 54.795, '_SolventAccessibilityD2050': 48.63, '_HydrophobicityD2001': 0.685, '_SecondaryStrD2075': 67.808, '_PolarityD3050': 66.438, '_PolarityD1001': 0.342, '_ChargeD2075': 75.0, '_NormalizedVDWVD3025': 28.425, '_SolventAccessibilityD1100': 98.288, '_SecondaryStrD1100': 100.0, '_NormalizedVDWVD1001': 0.685, '_NormalizedVDWVD2050': 41.438, '_NormalizedVDWVC2': 0.298, '_PolarizabilityC2': 0.384, '_PolarizabilityC3': 0.247, '_NormalizedVDWVD3001': 0.342, '_PolarizabilityC1': 0.37, '_SecondaryStrC2': 0.322, '_SecondaryStrC3': 0.384, '_ChargeT12': 0.144, '_ChargeT13': 0.01, '_ChargeD1001': 7.192, '_ChargeD1025': 30.479, '_NormalizedVDWVD2025': 15.411, '_NormalizedVDWVD3050': 53.767, '_SecondaryStrD1025': 19.863, '_SolventAccessibilityD1050': 47.26, '_PolarizabilityD3001': 0.342, '_PolarityD2075': 65.753, '_SecondaryStrD3001': 0.685, '_ChargeD2025': 23.973, '_HydrophobicityD2050': 60.274, '_PolarizabilityD1100': 98.288, '_HydrophobicityC1': 0.219, '_HydrophobicityC2': 0.476, '_SolventAccessibilityD2100': 100.0, '_PolarizabilityD2001': 0.685, '_PolarizabilityD1025': 28.767, '_NormalizedVDWVT13': 0.165, '_PolarizabilityD3050': 53.767, '_SolventAccessibilityT13': 0.278, '_SolventAccessibilityT12': 0.21, '_PolarityD1050': 41.096, '_ChargeD3075': 56.849, '_SolventAccessibilityD1001': 1.027, '_HydrophobicityC3': 0.305, '_HydrophobicityD3100': 97.603, '_SecondaryStrD1050': 53.082, '_ChargeD3001': 9.247, '_SecondaryStrD2050': 43.151, '_PolarityD2025': 16.438, '_NormalizedVDWVD2001': 1.37, '_HydrophobicityD3075': 64.726, '_SecondaryStrD2025': 22.945, '_SolventAccessibilityD2001': 7.192, '_HydrophobicityD1025': 30.479, '_ChargeD1050': 54.11, '_SolventAccessibilityD3025': 25.342, '_PolarizabilityD3075': 80.822, '_PolarityD2100': 95.89, '_SecondaryStrD3100': 97.945, '_PolarizabilityT13': 0.134, '_PolarizabilityT12': 0.265, '_SecondaryStrD2001': 2.74, '_NormalizedVDWVD1050': 50.685, '_PolarizabilityD1050': 51.027, '_SolventAccessibilityT23': 0.144, '_ChargeC3': 0.062, '_ChargeC2': 0.853, '_ChargeC1': 0.086, '_NormalizedVDWVT23': 0.155, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 16.438, '_SolventAccessibilityD3075': 76.027, '_HydrophobicityD2075': 84.589, '_HydrophobicityD1075': 66.438, '_ChargeD2050': 49.315, '_ChargeD3100': 97.945, '_SecondaryStrC1': 0.295, '_ChargeD3025': 22.603, '_PolarityD3001': 7.192, '_PolarityD3075': 87.671, '_PolarityD1025': 18.151, '_SecondaryStrT13': 0.168, '_SecondaryStrT12': 0.203, '_HydrophobicityD1001': 7.192, '_SolventAccessibilityD1075': 75.685, '_HydrophobicityD1050': 48.63, '_HydrophobicityT13': 0.158, '_HydrophobicityT12': 0.196, '_SecondaryStrD1001': 0.342, '_NormalizedVDWVD1100': 98.288, '_NormalizedVDWVD3075': 80.822, '_NormalizedVDWVD1025': 26.712, '_SolventAccessibilityD2075': 66.438, '_SecondaryStrD2100': 99.658, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 83.219, '_NormalizedVDWVT12': 0.213, '_PolarizabilityT23': 0.203, '_SolventAccessibilityD3050': 52.397, '_PolarityT23': 0.027, '_PolarityD2050': 47.945, '_HydrophobicityD2025': 28.767, '_PolarizabilityD2075': 68.493, '_HydrophobicityD3001': 0.342, '_HydrophobicityD1100': 100.0, '_ChargeD2001': 0.342, '_SolventAccessibilityC1': 0.469, '_SolventAccessibilityC2': 0.219, '_SolventAccessibilityC3': 0.312, '_PolarizabilityD1001': 1.027, '_NormalizedVDWVD2075': 66.096, '_ChargeD2100': 99.658, '_PolarizabilityD2100': 97.603, '_PolarityC1': 0.366, '_PolarityC3': 0.12, '_PolarityC2': 0.144}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
13
13
314
M8a-6
Ab
SARS-CoV2_WT
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGTELVMPGASVKLSCKTSGYTFTHYWMHWVKQRPGEGLEWIGEIAPSDNYVKYNQKFKGKSTLSVDRSSSTAYMQLSSLTSEDSAVYFCARPDNSGYPVYFDYWGQGTSLTVSS
DIVMTQSQKFMSTSLGDRVSISCKASQDVGTTVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGTGSGTDYTLTISSVAAEDLALYYCQQHYNTPYTFGGGTKLEIE
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDNSGYPVYFDY
QQHYNTPYT
Expected (7UZ5)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGT ELV MPGA SVKLSC KTSGY TFTHYWMHWVK QRPGEGL EWIGEI APSDN YVKY NQKFKGK STLSVD RSSST AYMQLS SLTSEDS AVYFCA RPDNSGY PVYFDY WGQG TSLTVS S
DI VMT QSQ KFMS TSLGD RVSISCK ASQDVG TTVAWYQ QKPGQSP KLLIYWAS TRHTGVPDR F TGTGSGTD YTLTISS VAA EDL ALYYCQ QHYNTPY T FGGGT KLEI E
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.302, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.256, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 53.363, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 47.534, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 53.363, '_NormalizedVDWVC2': 0.35, '_PolarizabilityC2': 0.448, '_PolarizabilityC3': 0.256, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 47.534, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.386, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 47.534, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 44.395, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 69.507, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.144, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.072, '_ChargeC2': 0.825, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 23.318, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 51.121, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.287, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.185, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.248, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 69.507, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.032, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.265, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.381, '_PolarityC3': 0.108, '_PolarityC2': 0.215}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
14
14
315
M8a-6
Ab
SARS-CoV2_Beta
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGTELVMPGASVKLSCKTSGYTFTHYWMHWVKQRPGEGLEWIGEIAPSDNYVKYNQKFKGKSTLSVDRSSSTAYMQLSSLTSEDSAVYFCARPDNSGYPVYFDYWGQGTSLTVSS
DIVMTQSQKFMSTSLGDRVSISCKASQDVGTTVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGTGSGTDYTLTISSVAAEDLALYYCQQHYNTPYTFGGGTKLEIE
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDNSGYPVYFDY
QQHYNTPYT
Expected (7UZ5)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVKGFNCYFPLQSYGFQPTYGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGT ELV MPGA SVKLSC KTSGY TFTHYWMHWVK QRPGEGL EWIGEI APSDN YVKY NQKFKGK STLSVD RSSST AYMQLS SLTSEDS AVYFCA RPDNSGY PVYFDY WGQG TSLTVS S
DI VMT QSQ KFMS TSLGD RVSISCK ASQDVG TTVAWYQ QKPGQSP KLLIYWAS TRHTGVPDR F TGTGSGTD YTLTISS VAA EDL ALYYCQ QHYNTPY T FGGGT KLEI E
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.682, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.306, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.26, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 66.368, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 51.57, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 49.327, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 76.233, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 51.57, '_NormalizedVDWVC2': 0.345, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.26, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.381, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 52.915, '_SecondaryStrD1025': 22.422, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 75.785, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.296, '_HydrophobicityC2': 0.39, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.185, '_PolarizabilityD3050': 52.915, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.284, '_PolarityD1050': 51.121, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 47.534, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 75.336, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.153, '_PolarizabilityT12': 0.252, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.18, '_ChargeC3': 0.067, '_ChargeC2': 0.83, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 77.578, '_HydrophobicityD2075': 76.682, '_HydrophobicityD1075': 66.816, '_ChargeD2050': 50.673, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.283, '_ChargeD3025': 20.628, '_PolarityD3001': 0.448, '_PolarityD3075': 74.439, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.18, '_SecondaryStrT12': 0.239, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.239, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 75.336, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 66.816, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 72.197, '_NormalizedVDWVT12': 0.221, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 50.224, '_PolarityT23': 0.032, '_PolarityD2050': 53.363, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 77.578, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.296, '_SolventAccessibilityC3': 0.269, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.991, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.386, '_PolarityC3': 0.108, '_PolarityC2': 0.211}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
15
15
316
M8a-6
Ab
SARS-CoV2_Delta
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGTELVMPGASVKLSCKTSGYTFTHYWMHWVKQRPGEGLEWIGEIAPSDNYVKYNQKFKGKSTLSVDRSSSTAYMQLSSLTSEDSAVYFCARPDNSGYPVYFDYWGQGTSLTVSS
DIVMTQSQKFMSTSLGDRVSISCKASQDVGTTVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGTGSGTDYTLTISSVAAEDLALYYCQQHYNTPYTFGGGTKLEIE
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDNSGYPVYFDY
QQHYNTPYT
Expected (7UZ5)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGT ELV MPGA SVKLSC KTSGY TFTHYWMHWVK QRPGEGL EWIGEI APSDN YVKY NQKFKGK STLSVD RSSST AYMQLS SLTSEDS AVYFCA RPDNSGY PVYFDY WGQG TSLTVS S
DI VMT QSQ KFMS TSLGD RVSISCK ASQDVG TTVAWYQ QKPGQSP KLLIYWAS TRHTGVPDR F TGTGSGTD YTLTISS VAA EDL ALYYCQ QHYNTPY T FGGGT KLEI E
{'_NormalizedVDWVD1075': 71.3, '_PolarityD1075': 76.682, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.293, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.35, '_NormalizedVDWVC3': 0.265, '_HydrophobicityT23': 0.221, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 26.906, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.198, '_PolarityT13': 0.113, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 74.439, '_PolarizabilityD2050': 52.018, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 68.161, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 49.327, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 52.018, '_NormalizedVDWVC2': 0.345, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.265, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.291, '_SecondaryStrC2': 0.372, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.176, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 49.776, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.215, '_HydrophobicityD2050': 48.43, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.309, '_HydrophobicityC2': 0.381, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.185, '_PolarizabilityD3050': 49.776, '_SolventAccessibilityT13': 0.23, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.309, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.076, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 26.906, '_ChargeD1050': 47.534, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 71.749, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 43.946, '_SolventAccessibilityT23': 0.203, '_ChargeC3': 0.072, '_ChargeC2': 0.816, '_ChargeC1': 0.112, '_NormalizedVDWVT23': 0.189, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.673, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.291, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 76.233, '_HydrophobicityD1050': 49.327, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.266, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 71.749, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.248, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.036, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.43, '_SolventAccessibilityC2': 0.309, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.377, '_PolarityC3': 0.117, '_PolarityC2': 0.215}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
16
16
317
M8a-6
Ab
SARS-CoV2_Omicron-BA1
1
1
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGTELVMPGASVKLSCKTSGYTFTHYWMHWVKQRPGEGLEWIGEIAPSDNYVKYNQKFKGKSTLSVDRSSSTAYMQLSSLTSEDSAVYFCARPDNSGYPVYFDYWGQGTSLTVSS
DIVMTQSQKFMSTSLGDRVSISCKASQDVGTTVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGTGSGTDYTLTISSVAAEDLALYYCQQHYNTPYTFGGGTKLEIE
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDNSGYPVYFDY
QQHYNTPYT
Expected (7UZ5)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGT ELV MPGA SVKLSC KTSGY TFTHYWMHWVK QRPGEGL EWIGEI APSDN YVKY NQKFKGK STLSVD RSSST AYMQLS SLTSEDS AVYFCA RPDNSGY PVYFDY WGQG TSLTVS S
DI VMT QSQ KFMS TSLGD RVSISCK ASQDVG TTVAWYQ QKPGQSP KLLIYWAS TRHTGVPDR F TGTGSGTD YTLTISS VAA EDL ALYYCQ QHYNTPY T FGGGT KLEI E
{'_NormalizedVDWVD1075': 73.543, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 29.148, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.284, '_PolarityD3025': 26.906, '_NormalizedVDWVC1': 0.341, '_NormalizedVDWVC3': 0.278, '_HydrophobicityT23': 0.234, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.189, '_PolarityT13': 0.113, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 48.43, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 22.422, '_PolarizabilityD3025': 25.112, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 60.987, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 25.112, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 47.982, '_NormalizedVDWVC2': 0.341, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.278, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.278, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.323, '_ChargeT12': 0.185, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.709, '_SecondaryStrD1025': 23.767, '_SolventAccessibilityD1050': 47.982, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 72.197, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.673, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.305, '_HydrophobicityC2': 0.372, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 26.009, '_NormalizedVDWVT13': 0.194, '_PolarizabilityD3050': 54.709, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.284, '_PolarityD1050': 47.982, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.323, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 54.709, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 48.43, '_PolarizabilityD1050': 45.74, '_SolventAccessibilityT23': 0.18, '_ChargeC3': 0.072, '_ChargeC2': 0.812, '_ChargeC1': 0.117, '_NormalizedVDWVT23': 0.207, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 78.924, '_HydrophobicityD2075': 77.578, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.224, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.3, '_ChargeD3025': 20.628, '_PolarityD3001': 0.448, '_PolarityD3075': 80.717, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.234, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 74.888, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.23, '_HydrophobicityT12': 0.234, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 26.009, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.221, '_PolarizabilityT23': 0.275, '_SolventAccessibilityD3050': 53.812, '_PolarityT23': 0.054, '_PolarityD2050': 48.43, '_HydrophobicityD2025': 26.009, '_PolarizabilityD2075': 75.785, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.305, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.094, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.39, '_PolarityC3': 0.126, '_PolarityC2': 0.206}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
17
17
318
M8a-6
Ab
SARS-CoV2_Omicron-BA2
1
1
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGTELVMPGASVKLSCKTSGYTFTHYWMHWVKQRPGEGLEWIGEIAPSDNYVKYNQKFKGKSTLSVDRSSSTAYMQLSSLTSEDSAVYFCARPDNSGYPVYFDYWGQGTSLTVSS
DIVMTQSQKFMSTSLGDRVSISCKASQDVGTTVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGTGSGTDYTLTISSVAAEDLALYYCQQHYNTPYTFGGGTKLEIE
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDNSGYPVYFDY
QQHYNTPYT
Expected (7UZ5)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGT ELV MPGA SVKLSC KTSGY TFTHYWMHWVK QRPGEGL EWIGEI APSDN YVKY NQKFKGK STLSVD RSSST AYMQLS SLTSEDS AVYFCA RPDNSGY PVYFDY WGQG TSLTVS S
DI VMT QSQ KFMS TSLGD RVSISCK ASQDVG TTVAWYQ QKPGQSP KLLIYWAS TRHTGVPDR F TGTGSGTD YTLTISS VAA EDL ALYYCQ QHYNTPY T FGGGT KLEI E
{'_NormalizedVDWVD1075': 73.543, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 29.148, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.293, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.341, '_NormalizedVDWVC3': 0.278, '_HydrophobicityT23': 0.239, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 20.628, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.189, '_PolarityT13': 0.108, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 48.43, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 22.422, '_PolarizabilityD3025': 23.767, '_SecondaryStrD3050': 49.327, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 60.987, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 23.767, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 47.982, '_NormalizedVDWVC2': 0.341, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.278, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.278, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.327, '_ChargeT12': 0.176, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.709, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 47.982, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 72.197, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.673, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.377, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 26.009, '_NormalizedVDWVT13': 0.198, '_PolarizabilityD3050': 54.709, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.279, '_PolarityD1050': 47.982, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.323, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 55.157, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 20.628, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.153, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 48.43, '_PolarizabilityD1050': 45.74, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.067, '_ChargeC2': 0.821, '_ChargeC1': 0.112, '_NormalizedVDWVT23': 0.203, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 77.578, '_HydrophobicityD2075': 77.578, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 49.776, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.296, '_ChargeD3025': 9.865, '_PolarityD3001': 0.448, '_PolarityD3075': 80.717, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.239, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 26.009, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 72.197, '_NormalizedVDWVT12': 0.225, '_PolarizabilityT23': 0.27, '_SolventAccessibilityD3050': 50.224, '_PolarityT23': 0.05, '_PolarityD2050': 46.637, '_HydrophobicityD2025': 27.803, '_PolarizabilityD2075': 75.785, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.444, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.256, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.094, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.39, '_PolarityC3': 0.121, '_PolarityC2': 0.211}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
18
18
321
M8a-6
Ab
RatG13
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGTELVMPGASVKLSCKTSGYTFTHYWMHWVKQRPGEGLEWIGEIAPSDNYVKYNQKFKGKSTLSVDRSSSTAYMQLSSLTSEDSAVYFCARPDNSGYPVYFDYWGQGTSLTVSS
DIVMTQSQKFMSTSLGDRVSISCKASQDVGTTVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGTGSGTDYTLTISSVAAEDLALYYCQQHYNTPYTFGGGTKLEIE
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDNSGYPVYFDY
QQHYNTPYT
Expected (7UZ5)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTDSIVRFPNITNLCPFGEVFNATTFASVYAWNRKRISNCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADSFVITGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSKHIDAKEGGNFNYLYRLFRKANLKPFERDISTEIYQAGSKPCNGQTGLNCYYPLYRYGFYPTDGVGHQPYRVVVLSFELLNAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGT ELV MPGA SVKLSC KTSGY TFTHYWMHWVK QRPGEGL EWIGEI APSDN YVKY NQKFKGK STLSVD RSSST AYMQLS SLTSEDS AVYFCA RPDNSGY PVYFDY WGQG TSLTVS S
DI VMT QSQ KFMS TSLGD RVSISCK ASQDVG TTVAWYQ QKPGQSP KLLIYWAS TRHTGVPDR F TGTGSGTD YTLTISS VAA EDL ALYYCQ QHYNTPY T FGGGT KLEI E
{'_NormalizedVDWVD1075': 71.3, '_PolarityD1075': 77.13, '_SecondaryStrD3025': 24.664, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.297, '_PolarityD3025': 26.906, '_NormalizedVDWVC1': 0.368, '_NormalizedVDWVC3': 0.265, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 25.112, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 26.906, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.185, '_PolarityT13': 0.099, '_ChargeT23': 0.122, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 73.991, '_PolarizabilityD2050': 51.57, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 68.161, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 25.112, '_SecondaryStrD3050': 48.879, '_SolventAccessibilityD2050': 53.363, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 74.439, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 25.112, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 51.57, '_NormalizedVDWVC2': 0.327, '_PolarizabilityC2': 0.426, '_PolarizabilityC3': 0.265, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.309, '_SecondaryStrC2': 0.386, '_SecondaryStrC3': 0.323, '_ChargeT12': 0.162, '_ChargeT13': 0.014, '_ChargeD1001': 0.448, '_ChargeD1025': 26.906, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.26, '_SecondaryStrD1025': 30.942, '_SolventAccessibilityD1050': 50.673, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 75.785, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 23.767, '_HydrophobicityD2050': 48.43, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.296, '_HydrophobicityC2': 0.399, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.215, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 54.26, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.293, '_PolarityD1050': 49.776, '_ChargeD3075': 56.951, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.305, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 56.502, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 43.498, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.076, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 26.906, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.135, '_PolarizabilityT12': 0.243, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.291, '_PolarizabilityD1050': 43.498, '_SolventAccessibilityT23': 0.171, '_ChargeC3': 0.076, '_ChargeC2': 0.816, '_ChargeC1': 0.108, '_NormalizedVDWVT23': 0.189, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 69.955, '_ChargeD2050': 49.776, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.291, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 71.749, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.189, '_SecondaryStrT12': 0.23, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 53.363, '_HydrophobicityT13': 0.207, '_HydrophobicityT12': 0.257, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 24.215, '_SolventAccessibilityD2075': 69.955, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.543, '_NormalizedVDWVT12': 0.212, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 46.188, '_PolarityT23': 0.045, '_PolarityD2050': 56.951, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 77.578, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.43, '_SolventAccessibilityC2': 0.296, '_SolventAccessibilityC3': 0.274, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.336, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.377, '_PolarityC3': 0.117, '_PolarityC2': 0.197}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
19
19
322
M8a-6
Ab
WIV1
1
1
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGTELVMPGASVKLSCKTSGYTFTHYWMHWVKQRPGEGLEWIGEIAPSDNYVKYNQKFKGKSTLSVDRSSSTAYMQLSSLTSEDSAVYFCARPDNSGYPVYFDYWGQGTSLTVSS
DIVMTQSQKFMSTSLGDRVSISCKASQDVGTTVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGTGSGTDYTLTISSVAAEDLALYYCQQHYNTPYTFGGGTKLEIE
IGHV1-69 (Mouse)
IGHJ2 (Mouse)
IGKV6-25 (Mouse)
IGKJ2 (Mouse)
ARPDNSGYPVYFDY
QQHYNTPYT
Expected (7UZ5)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVAPSKEVVRFPNITNLCPFGEVFNATTFPSVYAWERKRISNCVADYSVLYNSTSFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFTGCVLAWNTRNIDATQTGNYNYKYRSLRHGKLRPFERDISNVPFSPDGKPCTPPAFNCYWPLNDYGFYITNGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNF
QV QLQ QPGT ELV MPGA SVKLSC KTSGY TFTHYWMHWVK QRPGEGL EWIGEI APSDN YVKY NQKFKGK STLSVD RSSST AYMQLS SLTSEDS AVYFCA RPDNSGY PVYFDY WGQG TSLTVS S
DI VMT QSQ KFMS TSLGD RVSISCK ASQDVG TTVAWYQ QKPGQSP KLLIYWAS TRHTGVPDR F TGTGSGTD YTLTISS VAA EDL ALYYCQ QHYNTPY T FGGGT KLEI E
{'_NormalizedVDWVD1075': 71.622, '_PolarityD1075': 77.928, '_SecondaryStrD3025': 28.378, '_PolarityD3100': 97.297, '_ChargeD1100': 97.297, '_SecondaryStrT23': 0.312, '_PolarityD3025': 17.117, '_NormalizedVDWVC1': 0.383, '_NormalizedVDWVC3': 0.252, '_HydrophobicityT23': 0.253, '_SolventAccessibilityD1025': 25.225, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.55, '_ChargeD3050': 45.946, '_PolarityD2001': 1.802, '_SolventAccessibilityD2025': 27.027, '_HydrophobicityD3050': 48.198, '_PolarityT12': 0.19, '_PolarityT13': 0.095, '_ChargeT23': 0.127, '_HydrophobicityD2100': 95.495, '_SolventAccessibilityD3001': 1.802, '_ChargeD1075': 63.964, '_SecondaryStrD1075': 72.072, '_PolarizabilityD2050': 52.252, '_SolventAccessibilityD3100': 95.495, '_PolarizabilityD1075': 68.018, '_HydrophobicityD3025': 22.072, '_PolarizabilityD3025': 22.973, '_SecondaryStrD3050': 50.901, '_SolventAccessibilityD2050': 49.55, '_HydrophobicityD2001': 1.351, '_SecondaryStrD2075': 76.126, '_PolarityD3050': 47.748, '_PolarityD1001': 0.901, '_ChargeD2075': 76.577, '_NormalizedVDWVD3025': 22.973, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.198, '_NormalizedVDWVD1001': 1.351, '_NormalizedVDWVD2050': 51.802, '_NormalizedVDWVC2': 0.324, '_PolarizabilityC2': 0.437, '_PolarizabilityC3': 0.252, '_NormalizedVDWVD3001': 0.45, '_PolarizabilityC1': 0.311, '_SecondaryStrC2': 0.387, '_SecondaryStrC3': 0.342, '_ChargeT12': 0.158, '_ChargeT13': 0.018, '_ChargeD1001': 0.45, '_ChargeD1025': 17.117, '_NormalizedVDWVD2025': 22.523, '_NormalizedVDWVD3050': 50.0, '_SecondaryStrD1025': 22.523, '_SolventAccessibilityD1050': 48.198, '_PolarizabilityD3001': 0.45, '_PolarityD2075': 75.676, '_SecondaryStrD3001': 1.802, '_ChargeD2025': 24.775, '_HydrophobicityD2050': 50.45, '_PolarizabilityD1100': 95.946, '_HydrophobicityC1': 0.288, '_HydrophobicityC2': 0.396, '_SolventAccessibilityD2100': 99.55, '_PolarizabilityD2001': 0.901, '_PolarizabilityD1025': 25.676, '_NormalizedVDWVT13': 0.195, '_PolarizabilityD3050': 50.0, '_SolventAccessibilityT13': 0.276, '_SolventAccessibilityT12': 0.271, '_PolarityD1050': 48.198, '_ChargeD3075': 66.216, '_SolventAccessibilityD1001': 0.901, '_HydrophobicityC3': 0.315, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.252, '_ChargeD3001': 3.153, '_SecondaryStrD2050': 46.396, '_PolarityD2025': 18.919, '_NormalizedVDWVD2001': 0.901, '_HydrophobicityD3075': 77.928, '_SecondaryStrD2025': 22.072, '_SolventAccessibilityD2001': 0.45, '_HydrophobicityD1025': 27.027, '_ChargeD1050': 47.748, '_SolventAccessibilityD3025': 23.874, '_PolarizabilityD3075': 69.82, '_PolarityD2100': 99.55, '_SecondaryStrD3100': 99.55, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.267, '_SecondaryStrD2001': 0.901, '_NormalizedVDWVD1050': 48.649, '_PolarizabilityD1050': 44.144, '_SolventAccessibilityT23': 0.176, '_ChargeC3': 0.081, '_ChargeC2': 0.82, '_ChargeC1': 0.099, '_NormalizedVDWVT23': 0.176, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.523, '_SolventAccessibilityD3075': 73.423, '_HydrophobicityD2075': 73.874, '_HydrophobicityD1075': 68.468, '_ChargeD2050': 50.901, '_ChargeD3100': 95.946, '_SecondaryStrC1': 0.27, '_ChargeD3025': 20.721, '_PolarityD3001': 0.45, '_PolarityD3075': 63.964, '_PolarityD1025': 22.973, '_SecondaryStrT13': 0.176, '_SecondaryStrT12': 0.217, '_HydrophobicityD1001': 0.45, '_SolventAccessibilityD1075': 77.928, '_HydrophobicityD1050': 49.55, '_HydrophobicityT13': 0.204, '_HydrophobicityT12': 0.244, '_SecondaryStrD1001': 0.45, '_NormalizedVDWVD1100': 95.946, '_NormalizedVDWVD3075': 69.82, '_NormalizedVDWVD1025': 25.676, '_SolventAccessibilityD2075': 68.468, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.874, '_NormalizedVDWVT12': 0.217, '_PolarizabilityT23': 0.24, '_SolventAccessibilityD3050': 50.45, '_PolarityT23': 0.041, '_PolarityD2050': 57.207, '_HydrophobicityD2025': 24.775, '_PolarizabilityD2075': 78.378, '_HydrophobicityD3001': 0.901, '_HydrophobicityD1100': 99.55, '_ChargeD2001': 0.901, '_SolventAccessibilityC1': 0.432, '_SolventAccessibilityC2': 0.288, '_SolventAccessibilityC3': 0.279, '_PolarizabilityD1001': 1.351, '_NormalizedVDWVD2075': 81.982, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.55, '_PolarityC1': 0.383, '_PolarityC3': 0.104, '_PolarityC2': 0.203}
25,33,50,58,96,110,121
26,32,49,52,88,97,107
20
20
328
M8a-7
Ab
WIV1
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QAYLQQSGAEMVRPGASVKMSCKASGYTFNNYNMHWVKQTPSQGLEWIGGFYPGNDDTAYSQKFKGKATLTVDKSSSTAFMHLSSLTSEDSAVYFCARSLGRYYAMDYWGQGTSVTVSS
DIVLTQSPASLAVSLGQRATISCRASESVDDFGISYMNWFQQKPGQTPKLLIYGASNQGSGVPARFSGSGSGTDFSLNIHPMEEDDPAMYFCQQSKEVPYTFGGGTKLEIK
IGHV1-12 (Mouse)
IGHJ4 (Mouse)
IGKV3-2 (Mouse)
IGKJ2 (Mouse)
ARSLGRYYAMDY
QQSKEVPYT
ND
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVAPSKEVVRFPNITNLCPFGEVFNATTFPSVYAWERKRISNCVADYSVLYNSTSFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFTGCVLAWNTRNIDATQTGNYNYKYRSLRHGKLRPFERDISNVPFSPDGKPCTPPAFNCYWPLNDYGFYITNGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNF
QA YLQ QSGA EMV RPGA SVKMSCK ASGY TF NNYN MHWVK QTPSQGL EWIGGF YPGNDDTAYSQKFKG KATLTVD KSSS TAFMHLS SLTSEDS AVYFCA RSLGR YYAMD YWGQG TSVTVS S
D IVLT QSPA SLAVS LGQ RATISCRA SESVDDF GISYMNWF QQKPGQTP KLLIYG ASNQGSGVP ARF SGSGSGTD FSLNI HPMEEDDP AM YFC QQSKEVPY T FGGGT KLEI K
{'_NormalizedVDWVD1075': 71.622, '_PolarityD1075': 77.928, '_SecondaryStrD3025': 28.378, '_PolarityD3100': 97.297, '_ChargeD1100': 97.297, '_SecondaryStrT23': 0.312, '_PolarityD3025': 17.117, '_NormalizedVDWVC1': 0.383, '_NormalizedVDWVC3': 0.252, '_HydrophobicityT23': 0.253, '_SolventAccessibilityD1025': 25.225, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.55, '_ChargeD3050': 45.946, '_PolarityD2001': 1.802, '_SolventAccessibilityD2025': 27.027, '_HydrophobicityD3050': 48.198, '_PolarityT12': 0.19, '_PolarityT13': 0.095, '_ChargeT23': 0.127, '_HydrophobicityD2100': 95.495, '_SolventAccessibilityD3001': 1.802, '_ChargeD1075': 63.964, '_SecondaryStrD1075': 72.072, '_PolarizabilityD2050': 52.252, '_SolventAccessibilityD3100': 95.495, '_PolarizabilityD1075': 68.018, '_HydrophobicityD3025': 22.072, '_PolarizabilityD3025': 22.973, '_SecondaryStrD3050': 50.901, '_SolventAccessibilityD2050': 49.55, '_HydrophobicityD2001': 1.351, '_SecondaryStrD2075': 76.126, '_PolarityD3050': 47.748, '_PolarityD1001': 0.901, '_ChargeD2075': 76.577, '_NormalizedVDWVD3025': 22.973, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.198, '_NormalizedVDWVD1001': 1.351, '_NormalizedVDWVD2050': 51.802, '_NormalizedVDWVC2': 0.324, '_PolarizabilityC2': 0.437, '_PolarizabilityC3': 0.252, '_NormalizedVDWVD3001': 0.45, '_PolarizabilityC1': 0.311, '_SecondaryStrC2': 0.387, '_SecondaryStrC3': 0.342, '_ChargeT12': 0.158, '_ChargeT13': 0.018, '_ChargeD1001': 0.45, '_ChargeD1025': 17.117, '_NormalizedVDWVD2025': 22.523, '_NormalizedVDWVD3050': 50.0, '_SecondaryStrD1025': 22.523, '_SolventAccessibilityD1050': 48.198, '_PolarizabilityD3001': 0.45, '_PolarityD2075': 75.676, '_SecondaryStrD3001': 1.802, '_ChargeD2025': 24.775, '_HydrophobicityD2050': 50.45, '_PolarizabilityD1100': 95.946, '_HydrophobicityC1': 0.288, '_HydrophobicityC2': 0.396, '_SolventAccessibilityD2100': 99.55, '_PolarizabilityD2001': 0.901, '_PolarizabilityD1025': 25.676, '_NormalizedVDWVT13': 0.195, '_PolarizabilityD3050': 50.0, '_SolventAccessibilityT13': 0.276, '_SolventAccessibilityT12': 0.271, '_PolarityD1050': 48.198, '_ChargeD3075': 66.216, '_SolventAccessibilityD1001': 0.901, '_HydrophobicityC3': 0.315, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.252, '_ChargeD3001': 3.153, '_SecondaryStrD2050': 46.396, '_PolarityD2025': 18.919, '_NormalizedVDWVD2001': 0.901, '_HydrophobicityD3075': 77.928, '_SecondaryStrD2025': 22.072, '_SolventAccessibilityD2001': 0.45, '_HydrophobicityD1025': 27.027, '_ChargeD1050': 47.748, '_SolventAccessibilityD3025': 23.874, '_PolarizabilityD3075': 69.82, '_PolarityD2100': 99.55, '_SecondaryStrD3100': 99.55, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.267, '_SecondaryStrD2001': 0.901, '_NormalizedVDWVD1050': 48.649, '_PolarizabilityD1050': 44.144, '_SolventAccessibilityT23': 0.176, '_ChargeC3': 0.081, '_ChargeC2': 0.82, '_ChargeC1': 0.099, '_NormalizedVDWVT23': 0.176, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.523, '_SolventAccessibilityD3075': 73.423, '_HydrophobicityD2075': 73.874, '_HydrophobicityD1075': 68.468, '_ChargeD2050': 50.901, '_ChargeD3100': 95.946, '_SecondaryStrC1': 0.27, '_ChargeD3025': 20.721, '_PolarityD3001': 0.45, '_PolarityD3075': 63.964, '_PolarityD1025': 22.973, '_SecondaryStrT13': 0.176, '_SecondaryStrT12': 0.217, '_HydrophobicityD1001': 0.45, '_SolventAccessibilityD1075': 77.928, '_HydrophobicityD1050': 49.55, '_HydrophobicityT13': 0.204, '_HydrophobicityT12': 0.244, '_SecondaryStrD1001': 0.45, '_NormalizedVDWVD1100': 95.946, '_NormalizedVDWVD3075': 69.82, '_NormalizedVDWVD1025': 25.676, '_SolventAccessibilityD2075': 68.468, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.874, '_NormalizedVDWVT12': 0.217, '_PolarizabilityT23': 0.24, '_SolventAccessibilityD3050': 50.45, '_PolarityT23': 0.041, '_PolarityD2050': 57.207, '_HydrophobicityD2025': 24.775, '_PolarizabilityD2075': 78.378, '_HydrophobicityD3001': 0.901, '_HydrophobicityD1100': 99.55, '_ChargeD2001': 0.901, '_SolventAccessibilityC1': 0.432, '_SolventAccessibilityC2': 0.288, '_SolventAccessibilityC3': 0.279, '_PolarizabilityD1001': 1.351, '_NormalizedVDWVD2075': 81.982, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.55, '_PolarityC1': 0.383, '_PolarityC3': 0.104, '_PolarityC2': 0.203}
25,33,50,58,96,108,119
26,36,53,56,92,101,111
21
21
338
M8a-28
Ab
SARS-CoV2_WT
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVKPGASVKMSCKASGYNFNHYWISWVKQRPGQGLEWIGDIYPLSHFTTYNEKFTNRATLTVDTSSTTAYMQLNSLTSDDSAVFYCARWDYFDSRTFDYWGQGTTLTVSS
DILLTQFPAILSVSPGERVSFSCRASQTIGTNIHWYQQRINGSPRLLIKYASESISGIPSRFSGSGSGTDFSLSINNVESEDIADYYCQQINSWPLTFGAGTKLDLK
IGHV1-55 (Mouse)
IGHJ2 (Mouse)
IGKV5-48 (Mouse)
IGKJ5 (Mouse)
ARWDYFDSRTFDY
QQINSWPLT
Expected (7UZ6)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV KPGA SVKMSCK ASGYNFN HYWISWVK QRPGQGL EWIGDIY PLSHFTT Y NEKFTN RATLTVD TSST TAYMQLN SLTSDDS AVFYCARWD YFDSRT FDY WGQG TTLTVS S
DI LLT QFP AILSV SPGE RVSFSCR ASQTIGTN IHWYQQR INGSP RLLIKYA SESISGIPSRFSGSGSGTD FSLSI NNVES EDIADYYCQQ INSWP LTF GAGT KLD LK
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.302, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.256, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 53.363, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 47.534, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 53.363, '_NormalizedVDWVC2': 0.35, '_PolarizabilityC2': 0.448, '_PolarizabilityC3': 0.256, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 47.534, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.386, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 47.534, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 44.395, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 69.507, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.144, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.072, '_ChargeC2': 0.825, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 23.318, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 51.121, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.287, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.185, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.248, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 69.507, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.032, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.265, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.381, '_PolarityC3': 0.108, '_PolarityC2': 0.215}
25,33,50,58,96,109,120
26,32,49,52,88,97,107
22
22
339
M8a-28
Ab
SARS-CoV2_Beta
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVKPGASVKMSCKASGYNFNHYWISWVKQRPGQGLEWIGDIYPLSHFTTYNEKFTNRATLTVDTSSTTAYMQLNSLTSDDSAVFYCARWDYFDSRTFDYWGQGTTLTVSS
DILLTQFPAILSVSPGERVSFSCRASQTIGTNIHWYQQRINGSPRLLIKYASESISGIPSRFSGSGSGTDFSLSINNVESEDIADYYCQQINSWPLTFGAGTKLDLK
IGHV1-55 (Mouse)
IGHJ2 (Mouse)
IGKV5-48 (Mouse)
IGKJ5 (Mouse)
ARWDYFDSRTFDY
QQINSWPLT
Expected (7UZ6)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVKGFNCYFPLQSYGFQPTYGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV KPGA SVKMSCK ASGYNFN HYWISWVK QRPGQGL EWIGDIY PLSHFTT Y NEKFTN RATLTVD TSST TAYMQLN SLTSDDS AVFYCARWD YFDSRT FDY WGQG TTLTVS S
DI LLT QFP AILSV SPGE RVSFSCR ASQTIGTN IHWYQQR INGSP RLLIKYA SESISGIPSRFSGSGSGTD FSLSI NNVES EDIADYYCQQ INSWP LTF GAGT KLD LK
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.682, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.306, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.26, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 66.368, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 51.57, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 49.327, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 76.233, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 51.57, '_NormalizedVDWVC2': 0.345, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.26, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.381, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 52.915, '_SecondaryStrD1025': 22.422, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 75.785, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.296, '_HydrophobicityC2': 0.39, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.185, '_PolarizabilityD3050': 52.915, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.284, '_PolarityD1050': 51.121, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 47.534, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 75.336, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.153, '_PolarizabilityT12': 0.252, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.18, '_ChargeC3': 0.067, '_ChargeC2': 0.83, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 77.578, '_HydrophobicityD2075': 76.682, '_HydrophobicityD1075': 66.816, '_ChargeD2050': 50.673, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.283, '_ChargeD3025': 20.628, '_PolarityD3001': 0.448, '_PolarityD3075': 74.439, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.18, '_SecondaryStrT12': 0.239, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.239, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 75.336, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 66.816, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 72.197, '_NormalizedVDWVT12': 0.221, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 50.224, '_PolarityT23': 0.032, '_PolarityD2050': 53.363, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 77.578, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.296, '_SolventAccessibilityC3': 0.269, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.991, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.386, '_PolarityC3': 0.108, '_PolarityC2': 0.211}
25,33,50,58,96,109,120
26,32,49,52,88,97,107
23
23
340
M8a-28
Ab
SARS-CoV2_Delta
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVKPGASVKMSCKASGYNFNHYWISWVKQRPGQGLEWIGDIYPLSHFTTYNEKFTNRATLTVDTSSTTAYMQLNSLTSDDSAVFYCARWDYFDSRTFDYWGQGTTLTVSS
DILLTQFPAILSVSPGERVSFSCRASQTIGTNIHWYQQRINGSPRLLIKYASESISGIPSRFSGSGSGTDFSLSINNVESEDIADYYCQQINSWPLTFGAGTKLDLK
IGHV1-55 (Mouse)
IGHJ2 (Mouse)
IGKV5-48 (Mouse)
IGKJ5 (Mouse)
ARWDYFDSRTFDY
QQINSWPLT
Expected (7UZ6)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV KPGA SVKMSCK ASGYNFN HYWISWVK QRPGQGL EWIGDIY PLSHFTT Y NEKFTN RATLTVD TSST TAYMQLN SLTSDDS AVFYCARWD YFDSRT FDY WGQG TTLTVS S
DI LLT QFP AILSV SPGE RVSFSCR ASQTIGTN IHWYQQR INGSP RLLIKYA SESISGIPSRFSGSGSGTD FSLSI NNVES EDIADYYCQQ INSWP LTF GAGT KLD LK
{'_NormalizedVDWVD1075': 71.3, '_PolarityD1075': 76.682, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.293, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.35, '_NormalizedVDWVC3': 0.265, '_HydrophobicityT23': 0.221, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 26.906, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.198, '_PolarityT13': 0.113, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 74.439, '_PolarizabilityD2050': 52.018, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 68.161, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 49.327, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 52.018, '_NormalizedVDWVC2': 0.345, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.265, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.291, '_SecondaryStrC2': 0.372, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.176, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 49.776, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.215, '_HydrophobicityD2050': 48.43, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.309, '_HydrophobicityC2': 0.381, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.185, '_PolarizabilityD3050': 49.776, '_SolventAccessibilityT13': 0.23, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.309, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.076, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 26.906, '_ChargeD1050': 47.534, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 71.749, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 43.946, '_SolventAccessibilityT23': 0.203, '_ChargeC3': 0.072, '_ChargeC2': 0.816, '_ChargeC1': 0.112, '_NormalizedVDWVT23': 0.189, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.673, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.291, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 76.233, '_HydrophobicityD1050': 49.327, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.266, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 71.749, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.248, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.036, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.43, '_SolventAccessibilityC2': 0.309, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.377, '_PolarityC3': 0.117, '_PolarityC2': 0.215}
25,33,50,58,96,109,120
26,32,49,52,88,97,107
24
24
341
M8a-28
Ab
SARS-CoV2_Omicron-BA1
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVKPGASVKMSCKASGYNFNHYWISWVKQRPGQGLEWIGDIYPLSHFTTYNEKFTNRATLTVDTSSTTAYMQLNSLTSDDSAVFYCARWDYFDSRTFDYWGQGTTLTVSS
DILLTQFPAILSVSPGERVSFSCRASQTIGTNIHWYQQRINGSPRLLIKYASESISGIPSRFSGSGSGTDFSLSINNVESEDIADYYCQQINSWPLTFGAGTKLDLK
IGHV1-55 (Mouse)
IGHJ2 (Mouse)
IGKV5-48 (Mouse)
IGKJ5 (Mouse)
ARWDYFDSRTFDY
QQINSWPLT
Expected (7UZ6)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNLAPFFTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYSFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV KPGA SVKMSCK ASGYNFN HYWISWVK QRPGQGL EWIGDIY PLSHFTT Y NEKFTN RATLTVD TSST TAYMQLN SLTSDDS AVFYCARWD YFDSRT FDY WGQG TTLTVS S
DI LLT QFP AILSV SPGE RVSFSCR ASQTIGTN IHWYQQR INGSP RLLIKYA SESISGIPSRFSGSGSGTD FSLSI NNVES EDIADYYCQQ INSWP LTF GAGT KLD LK
{'_NormalizedVDWVD1075': 73.543, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 29.148, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.284, '_PolarityD3025': 26.906, '_NormalizedVDWVC1': 0.341, '_NormalizedVDWVC3': 0.278, '_HydrophobicityT23': 0.234, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.189, '_PolarityT13': 0.113, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 48.43, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 22.422, '_PolarizabilityD3025': 25.112, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 60.987, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 25.112, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 47.982, '_NormalizedVDWVC2': 0.341, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.278, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.278, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.323, '_ChargeT12': 0.185, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.709, '_SecondaryStrD1025': 23.767, '_SolventAccessibilityD1050': 47.982, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 72.197, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.673, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.305, '_HydrophobicityC2': 0.372, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 26.009, '_NormalizedVDWVT13': 0.194, '_PolarizabilityD3050': 54.709, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.284, '_PolarityD1050': 47.982, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.323, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 54.709, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 48.43, '_PolarizabilityD1050': 45.74, '_SolventAccessibilityT23': 0.18, '_ChargeC3': 0.072, '_ChargeC2': 0.812, '_ChargeC1': 0.117, '_NormalizedVDWVT23': 0.207, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 78.924, '_HydrophobicityD2075': 77.578, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.224, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.3, '_ChargeD3025': 20.628, '_PolarityD3001': 0.448, '_PolarityD3075': 80.717, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.234, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 74.888, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.23, '_HydrophobicityT12': 0.234, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 26.009, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.221, '_PolarizabilityT23': 0.275, '_SolventAccessibilityD3050': 53.812, '_PolarityT23': 0.054, '_PolarityD2050': 48.43, '_HydrophobicityD2025': 26.009, '_PolarizabilityD2075': 75.785, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.305, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.094, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.39, '_PolarityC3': 0.126, '_PolarityC2': 0.206}
25,33,50,58,96,109,120
26,32,49,52,88,97,107
25
25
342
M8a-28
Ab
SARS-CoV2_Omicron-BA2
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVKPGASVKMSCKASGYNFNHYWISWVKQRPGQGLEWIGDIYPLSHFTTYNEKFTNRATLTVDTSSTTAYMQLNSLTSDDSAVFYCARWDYFDSRTFDYWGQGTTLTVSS
DILLTQFPAILSVSPGERVSFSCRASQTIGTNIHWYQQRINGSPRLLIKYASESISGIPSRFSGSGSGTDFSLSINNVESEDIADYYCQQINSWPLTFGAGTKLDLK
IGHV1-55 (Mouse)
IGHJ2 (Mouse)
IGKV5-48 (Mouse)
IGKJ5 (Mouse)
ARWDYFDSRTFDY
QQINSWPLT
Expected (7UZ6)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFDEVFNATRFASVYAWNRKRISNCVADYSVLYNFAPFFAFKCYGVSPTKLNDLCFTNVYADSFVIRGNEVSQIAPGQTGNIADYNYKLPDDFTGCVIAWNSNKLDSKVSGNYNYLYRLFRKSNLKPFERDISTEIYQAGNKPCNGVAGFNCYFPLRSYGFRPTYGVGHQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV KPGA SVKMSCK ASGYNFN HYWISWVK QRPGQGL EWIGDIY PLSHFTT Y NEKFTN RATLTVD TSST TAYMQLN SLTSDDS AVFYCARWD YFDSRT FDY WGQG TTLTVS S
DI LLT QFP AILSV SPGE RVSFSCR ASQTIGTN IHWYQQR INGSP RLLIKYA SESISGIPSRFSGSGSGTD FSLSI NNVES EDIADYYCQQ INSWP LTF GAGT KLD LK
{'_NormalizedVDWVD1075': 73.543, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 29.148, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.293, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.341, '_NormalizedVDWVC3': 0.278, '_HydrophobicityT23': 0.239, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 39.462, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 20.628, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.189, '_PolarityT13': 0.108, '_ChargeT23': 0.108, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 48.43, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 22.422, '_PolarizabilityD3025': 23.767, '_SecondaryStrD3050': 49.327, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 60.987, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 23.767, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 47.982, '_NormalizedVDWVC2': 0.341, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.278, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.278, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.327, '_ChargeT12': 0.176, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.709, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 47.982, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 72.197, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.673, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.377, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 26.009, '_NormalizedVDWVT13': 0.198, '_PolarizabilityD3050': 54.709, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.279, '_PolarityD1050': 47.982, '_ChargeD3075': 55.605, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.323, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 55.157, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 18.834, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 20.628, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 24.664, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.153, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 48.43, '_PolarizabilityD1050': 45.74, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.067, '_ChargeC2': 0.821, '_ChargeC1': 0.112, '_NormalizedVDWVT23': 0.203, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 77.578, '_HydrophobicityD2075': 77.578, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 49.776, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.296, '_ChargeD3025': 9.865, '_PolarityD3001': 0.448, '_PolarityD3075': 80.717, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.239, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 26.009, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 72.197, '_NormalizedVDWVT12': 0.225, '_PolarizabilityT23': 0.27, '_SolventAccessibilityD3050': 50.224, '_PolarityT23': 0.05, '_PolarityD2050': 46.637, '_HydrophobicityD2025': 27.803, '_PolarizabilityD2075': 75.785, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.444, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.256, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 73.094, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.39, '_PolarityC3': 0.121, '_PolarityC2': 0.211}
25,33,50,58,96,109,120
26,32,49,52,88,97,107
26
26
343
M8a-28
Ab
RatG13
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVKPGASVKMSCKASGYNFNHYWISWVKQRPGQGLEWIGDIYPLSHFTTYNEKFTNRATLTVDTSSTTAYMQLNSLTSDDSAVFYCARWDYFDSRTFDYWGQGTTLTVSS
DILLTQFPAILSVSPGERVSFSCRASQTIGTNIHWYQQRINGSPRLLIKYASESISGIPSRFSGSGSGTDFSLSINNVESEDIADYYCQQINSWPLTFGAGTKLDLK
IGHV1-55 (Mouse)
IGHJ2 (Mouse)
IGKV5-48 (Mouse)
IGKJ5 (Mouse)
ARWDYFDSRTFDY
QQINSWPLT
Expected (7UZ6)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTDSIVRFPNITNLCPFGEVFNATTFASVYAWNRKRISNCVADYSVLYNSTSFSTFKCYGVSPTKLNDLCFTNVYADSFVITGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSKHIDAKEGGNFNYLYRLFRKANLKPFERDISTEIYQAGSKPCNGQTGLNCYYPLYRYGFYPTDGVGHQPYRVVVLSFELLNAPATVCGPKKSTNLVKNKCVNF
QV QLQ QPGA ELV KPGA SVKMSCK ASGYNFN HYWISWVK QRPGQGL EWIGDIY PLSHFTT Y NEKFTN RATLTVD TSST TAYMQLN SLTSDDS AVFYCARWD YFDSRT FDY WGQG TTLTVS S
DI LLT QFP AILSV SPGE RVSFSCR ASQTIGTN IHWYQQR INGSP RLLIKYA SESISGIPSRFSGSGSGTD FSLSI NNVES EDIADYYCQQ INSWP LTF GAGT KLD LK
{'_NormalizedVDWVD1075': 71.3, '_PolarityD1075': 77.13, '_SecondaryStrD3025': 24.664, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.297, '_PolarityD3025': 26.906, '_NormalizedVDWVC1': 0.368, '_NormalizedVDWVC3': 0.265, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 25.112, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 26.906, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.185, '_PolarityT13': 0.099, '_ChargeT23': 0.122, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 71.749, '_SecondaryStrD1075': 73.991, '_PolarizabilityD2050': 51.57, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 68.161, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 25.112, '_SecondaryStrD3050': 48.879, '_SolventAccessibilityD2050': 53.363, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 74.439, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 75.785, '_NormalizedVDWVD3025': 25.112, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 51.57, '_NormalizedVDWVC2': 0.327, '_PolarizabilityC2': 0.426, '_PolarizabilityC3': 0.265, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.309, '_SecondaryStrC2': 0.386, '_SecondaryStrC3': 0.323, '_ChargeT12': 0.162, '_ChargeT13': 0.014, '_ChargeD1001': 0.448, '_ChargeD1025': 26.906, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 54.26, '_SecondaryStrD1025': 30.942, '_SolventAccessibilityD1050': 50.673, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 75.785, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 23.767, '_HydrophobicityD2050': 48.43, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.296, '_HydrophobicityC2': 0.399, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.215, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 54.26, '_SolventAccessibilityT13': 0.243, '_SolventAccessibilityT12': 0.293, '_PolarityD1050': 49.776, '_ChargeD3075': 56.951, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.305, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 56.502, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 43.498, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.076, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 26.906, '_ChargeD1050': 56.502, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 76.682, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.135, '_PolarizabilityT12': 0.243, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.291, '_PolarizabilityD1050': 43.498, '_SolventAccessibilityT23': 0.171, '_ChargeC3': 0.076, '_ChargeC2': 0.816, '_ChargeC1': 0.108, '_NormalizedVDWVT23': 0.189, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 69.955, '_ChargeD2050': 49.776, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.291, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 71.749, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.189, '_SecondaryStrT12': 0.23, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 53.363, '_HydrophobicityT13': 0.207, '_HydrophobicityT12': 0.257, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 76.682, '_NormalizedVDWVD1025': 24.215, '_SolventAccessibilityD2075': 69.955, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.543, '_NormalizedVDWVT12': 0.212, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 46.188, '_PolarityT23': 0.045, '_PolarityD2050': 56.951, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 77.578, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.43, '_SolventAccessibilityC2': 0.296, '_SolventAccessibilityC3': 0.274, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.336, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.377, '_PolarityC3': 0.117, '_PolarityC2': 0.197}
25,33,50,58,96,109,120
26,32,49,52,88,97,107
27
27
344
M8a-28
Ab
SARS-CoV1
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVKPGASVKMSCKASGYNFNHYWISWVKQRPGQGLEWIGDIYPLSHFTTYNEKFTNRATLTVDTSSTTAYMQLNSLTSDDSAVFYCARWDYFDSRTFDYWGQGTTLTVSS
DILLTQFPAILSVSPGERVSFSCRASQTIGTNIHWYQQRINGSPRLLIKYASESISGIPSRFSGSGSGTDFSLSINNVESEDIADYYCQQINSWPLTFGAGTKLDLK
IGHV1-55 (Mouse)
IGHJ2 (Mouse)
IGKV5-48 (Mouse)
IGKJ5 (Mouse)
ARWDYFDSRTFDY
QQINSWPLT
Expected (7UZ6)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVVPSGDVVRFPNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNF
QV QLQ QPGA ELV KPGA SVKMSCK ASGYNFN HYWISWVK QRPGQGL EWIGDIY PLSHFTT Y NEKFTN RATLTVD TSST TAYMQLN SLTSDDS AVFYCARWD YFDSRT FDY WGQG TTLTVS S
DI LLT QFP AILSV SPGE RVSFSCR ASQTIGTN IHWYQQR INGSP RLLIKYA SESISGIPSRFSGSGSGTD FSLSI NNVES EDIADYYCQQ INSWP LTF GAGT KLD LK
{'_NormalizedVDWVD1075': 73.423, '_PolarityD1075': 77.027, '_SecondaryStrD3025': 25.676, '_PolarityD3100': 97.297, '_ChargeD1100': 97.297, '_SecondaryStrT23': 0.312, '_PolarityD3025': 17.117, '_NormalizedVDWVC1': 0.383, '_NormalizedVDWVC3': 0.261, '_HydrophobicityT23': 0.24, '_SolventAccessibilityD1025': 22.523, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.55, '_ChargeD3050': 45.946, '_PolarityD2001': 1.802, '_SolventAccessibilityD2025': 23.423, '_HydrophobicityD3050': 45.045, '_PolarityT12': 0.19, '_PolarityT13': 0.104, '_ChargeT23': 0.131, '_HydrophobicityD2100': 95.495, '_SolventAccessibilityD3001': 1.802, '_ChargeD1075': 63.964, '_SecondaryStrD1075': 74.775, '_PolarizabilityD2050': 51.802, '_SolventAccessibilityD3100': 95.495, '_PolarizabilityD1075': 71.171, '_HydrophobicityD3025': 22.072, '_PolarizabilityD3025': 22.973, '_SecondaryStrD3050': 49.55, '_SolventAccessibilityD2050': 49.099, '_HydrophobicityD2001': 1.802, '_SecondaryStrD2075': 76.577, '_PolarityD3050': 47.748, '_PolarityD1001': 0.901, '_ChargeD2075': 76.577, '_NormalizedVDWVD3025': 22.973, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.198, '_NormalizedVDWVD1001': 1.802, '_NormalizedVDWVD2050': 48.198, '_NormalizedVDWVC2': 0.315, '_PolarizabilityC2': 0.428, '_PolarizabilityC3': 0.261, '_NormalizedVDWVD3001': 0.45, '_PolarizabilityC1': 0.311, '_SecondaryStrC2': 0.392, '_SecondaryStrC3': 0.342, '_ChargeT12': 0.163, '_ChargeT13': 0.014, '_ChargeD1001': 0.45, '_ChargeD1025': 17.117, '_NormalizedVDWVD2025': 22.072, '_NormalizedVDWVD3050': 50.0, '_SecondaryStrD1025': 27.027, '_SolventAccessibilityD1050': 45.045, '_PolarizabilityD3001': 0.45, '_PolarityD2075': 75.676, '_SecondaryStrD3001': 1.802, '_ChargeD2025': 24.775, '_HydrophobicityD2050': 54.054, '_PolarizabilityD1100': 95.946, '_HydrophobicityC1': 0.279, '_HydrophobicityC2': 0.396, '_SolventAccessibilityD2100': 99.55, '_PolarizabilityD2001': 0.901, '_PolarizabilityD1025': 26.126, '_NormalizedVDWVT13': 0.186, '_PolarizabilityD3050': 50.0, '_SolventAccessibilityT13': 0.271, '_SolventAccessibilityT12': 0.276, '_PolarityD1050': 48.198, '_ChargeD3075': 66.216, '_SolventAccessibilityD1001': 0.901, '_HydrophobicityC3': 0.324, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.252, '_ChargeD3001': 3.153, '_SecondaryStrD2050': 45.045, '_PolarityD2025': 18.919, '_NormalizedVDWVD2001': 0.901, '_HydrophobicityD3075': 77.027, '_SecondaryStrD2025': 22.072, '_SolventAccessibilityD2001': 0.45, '_HydrophobicityD1025': 23.423, '_ChargeD1050': 47.748, '_SolventAccessibilityD3025': 24.324, '_PolarizabilityD3075': 65.766, '_PolarityD2100': 99.55, '_SecondaryStrD3100': 99.55, '_PolarizabilityT13': 0.14, '_PolarizabilityT12': 0.24, '_SecondaryStrD2001': 0.901, '_NormalizedVDWVD1050': 49.099, '_PolarizabilityD1050': 45.495, '_SolventAccessibilityT23': 0.163, '_ChargeC3': 0.081, '_ChargeC2': 0.82, '_ChargeC1': 0.099, '_NormalizedVDWVT23': 0.167, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.072, '_SolventAccessibilityD3075': 74.324, '_HydrophobicityD2075': 74.775, '_HydrophobicityD1075': 67.117, '_ChargeD2050': 50.901, '_ChargeD3100': 95.946, '_SecondaryStrC1': 0.266, '_ChargeD3025': 20.721, '_PolarityD3001': 0.45, '_PolarityD3075': 63.964, '_PolarityD1025': 22.973, '_SecondaryStrT13': 0.167, '_SecondaryStrT12': 0.217, '_HydrophobicityD1001': 0.45, '_SolventAccessibilityD1075': 76.126, '_HydrophobicityD1050': 49.099, '_HydrophobicityT13': 0.208, '_HydrophobicityT12': 0.231, '_SecondaryStrD1001': 0.45, '_NormalizedVDWVD1100': 95.946, '_NormalizedVDWVD3075': 65.766, '_NormalizedVDWVD1025': 26.126, '_SolventAccessibilityD2075': 67.117, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 72.523, '_NormalizedVDWVT12': 0.199, '_PolarizabilityT23': 0.231, '_SolventAccessibilityD3050': 56.757, '_PolarityT23': 0.036, '_PolarityD2050': 58.559, '_HydrophobicityD2025': 26.126, '_PolarizabilityD2075': 77.928, '_HydrophobicityD3001': 0.901, '_HydrophobicityD1100': 99.55, '_ChargeD2001': 0.901, '_SolventAccessibilityC1': 0.437, '_SolventAccessibilityC2': 0.279, '_SolventAccessibilityC3': 0.284, '_PolarizabilityD1001': 2.252, '_NormalizedVDWVD2075': 78.378, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.55, '_PolarityC1': 0.396, '_PolarityC3': 0.104, '_PolarityC2': 0.189}
25,33,50,58,96,109,120
26,32,49,52,88,97,107
28
28
345
M8a-28
Ab
WIV1
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVQLQQPGAELVKPGASVKMSCKASGYNFNHYWISWVKQRPGQGLEWIGDIYPLSHFTTYNEKFTNRATLTVDTSSTTAYMQLNSLTSDDSAVFYCARWDYFDSRTFDYWGQGTTLTVSS
DILLTQFPAILSVSPGERVSFSCRASQTIGTNIHWYQQRINGSPRLLIKYASESISGIPSRFSGSGSGTDFSLSINNVESEDIADYYCQQINSWPLTFGAGTKLDLK
IGHV1-55 (Mouse)
IGHJ2 (Mouse)
IGKV5-48 (Mouse)
IGKJ5 (Mouse)
ARWDYFDSRTFDY
QQINSWPLT
Expected (7UZ6)
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVAPSKEVVRFPNITNLCPFGEVFNATTFPSVYAWERKRISNCVADYSVLYNSTSFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFTGCVLAWNTRNIDATQTGNYNYKYRSLRHGKLRPFERDISNVPFSPDGKPCTPPAFNCYWPLNDYGFYITNGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNF
QV QLQ QPGA ELV KPGA SVKMSCK ASGYNFN HYWISWVK QRPGQGL EWIGDIY PLSHFTT Y NEKFTN RATLTVD TSST TAYMQLN SLTSDDS AVFYCARWD YFDSRT FDY WGQG TTLTVS S
DI LLT QFP AILSV SPGE RVSFSCR ASQTIGTN IHWYQQR INGSP RLLIKYA SESISGIPSRFSGSGSGTD FSLSI NNVES EDIADYYCQQ INSWP LTF GAGT KLD LK
{'_NormalizedVDWVD1075': 71.622, '_PolarityD1075': 77.928, '_SecondaryStrD3025': 28.378, '_PolarityD3100': 97.297, '_ChargeD1100': 97.297, '_SecondaryStrT23': 0.312, '_PolarityD3025': 17.117, '_NormalizedVDWVC1': 0.383, '_NormalizedVDWVC3': 0.252, '_HydrophobicityT23': 0.253, '_SolventAccessibilityD1025': 25.225, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.55, '_ChargeD3050': 45.946, '_PolarityD2001': 1.802, '_SolventAccessibilityD2025': 27.027, '_HydrophobicityD3050': 48.198, '_PolarityT12': 0.19, '_PolarityT13': 0.095, '_ChargeT23': 0.127, '_HydrophobicityD2100': 95.495, '_SolventAccessibilityD3001': 1.802, '_ChargeD1075': 63.964, '_SecondaryStrD1075': 72.072, '_PolarizabilityD2050': 52.252, '_SolventAccessibilityD3100': 95.495, '_PolarizabilityD1075': 68.018, '_HydrophobicityD3025': 22.072, '_PolarizabilityD3025': 22.973, '_SecondaryStrD3050': 50.901, '_SolventAccessibilityD2050': 49.55, '_HydrophobicityD2001': 1.351, '_SecondaryStrD2075': 76.126, '_PolarityD3050': 47.748, '_PolarityD1001': 0.901, '_ChargeD2075': 76.577, '_NormalizedVDWVD3025': 22.973, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.198, '_NormalizedVDWVD1001': 1.351, '_NormalizedVDWVD2050': 51.802, '_NormalizedVDWVC2': 0.324, '_PolarizabilityC2': 0.437, '_PolarizabilityC3': 0.252, '_NormalizedVDWVD3001': 0.45, '_PolarizabilityC1': 0.311, '_SecondaryStrC2': 0.387, '_SecondaryStrC3': 0.342, '_ChargeT12': 0.158, '_ChargeT13': 0.018, '_ChargeD1001': 0.45, '_ChargeD1025': 17.117, '_NormalizedVDWVD2025': 22.523, '_NormalizedVDWVD3050': 50.0, '_SecondaryStrD1025': 22.523, '_SolventAccessibilityD1050': 48.198, '_PolarizabilityD3001': 0.45, '_PolarityD2075': 75.676, '_SecondaryStrD3001': 1.802, '_ChargeD2025': 24.775, '_HydrophobicityD2050': 50.45, '_PolarizabilityD1100': 95.946, '_HydrophobicityC1': 0.288, '_HydrophobicityC2': 0.396, '_SolventAccessibilityD2100': 99.55, '_PolarizabilityD2001': 0.901, '_PolarizabilityD1025': 25.676, '_NormalizedVDWVT13': 0.195, '_PolarizabilityD3050': 50.0, '_SolventAccessibilityT13': 0.276, '_SolventAccessibilityT12': 0.271, '_PolarityD1050': 48.198, '_ChargeD3075': 66.216, '_SolventAccessibilityD1001': 0.901, '_HydrophobicityC3': 0.315, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.252, '_ChargeD3001': 3.153, '_SecondaryStrD2050': 46.396, '_PolarityD2025': 18.919, '_NormalizedVDWVD2001': 0.901, '_HydrophobicityD3075': 77.928, '_SecondaryStrD2025': 22.072, '_SolventAccessibilityD2001': 0.45, '_HydrophobicityD1025': 27.027, '_ChargeD1050': 47.748, '_SolventAccessibilityD3025': 23.874, '_PolarizabilityD3075': 69.82, '_PolarityD2100': 99.55, '_SecondaryStrD3100': 99.55, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.267, '_SecondaryStrD2001': 0.901, '_NormalizedVDWVD1050': 48.649, '_PolarizabilityD1050': 44.144, '_SolventAccessibilityT23': 0.176, '_ChargeC3': 0.081, '_ChargeC2': 0.82, '_ChargeC1': 0.099, '_NormalizedVDWVT23': 0.176, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.523, '_SolventAccessibilityD3075': 73.423, '_HydrophobicityD2075': 73.874, '_HydrophobicityD1075': 68.468, '_ChargeD2050': 50.901, '_ChargeD3100': 95.946, '_SecondaryStrC1': 0.27, '_ChargeD3025': 20.721, '_PolarityD3001': 0.45, '_PolarityD3075': 63.964, '_PolarityD1025': 22.973, '_SecondaryStrT13': 0.176, '_SecondaryStrT12': 0.217, '_HydrophobicityD1001': 0.45, '_SolventAccessibilityD1075': 77.928, '_HydrophobicityD1050': 49.55, '_HydrophobicityT13': 0.204, '_HydrophobicityT12': 0.244, '_SecondaryStrD1001': 0.45, '_NormalizedVDWVD1100': 95.946, '_NormalizedVDWVD3075': 69.82, '_NormalizedVDWVD1025': 25.676, '_SolventAccessibilityD2075': 68.468, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.874, '_NormalizedVDWVT12': 0.217, '_PolarizabilityT23': 0.24, '_SolventAccessibilityD3050': 50.45, '_PolarityT23': 0.041, '_PolarityD2050': 57.207, '_HydrophobicityD2025': 24.775, '_PolarizabilityD2075': 78.378, '_HydrophobicityD3001': 0.901, '_HydrophobicityD1100': 99.55, '_ChargeD2001': 0.901, '_SolventAccessibilityC1': 0.432, '_SolventAccessibilityC2': 0.288, '_SolventAccessibilityC3': 0.279, '_PolarizabilityD1001': 1.351, '_NormalizedVDWVD2075': 81.982, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.55, '_PolarityC1': 0.383, '_PolarityC3': 0.104, '_PolarityC2': 0.203}
25,33,50,58,96,109,120
26,32,49,52,88,97,107
29
29
349
M8a-30
Ab
SARS-CoV2_WT
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVHLQQSGPELVKPGASVKISCKASGYGFSSSWMNWVKQRPGKGLEWIGRIYPGDGDTNYNDKFQGKATLTADRSSSTAYMHLTSLTSADSAVYFCARSLLYSFDYWGQGTTLTVSS
DVVVTQTPLSLPVSFGDQVSISCRSSQSLAGSYGHTYLSWYLHKSGQSPQLLIYGISNRFSGVPDRFSGSGSGTDFTLKISTIKPEDLGMYYCLQGTHQPLTFGAGTKLELK
IGHV1-82 (Mouse)
IGHJ2 (Mouse)
IGKV1-88 (Mouse)
IGKJ5 (Mouse)
ARSLLYSFDY
LQGTHQPLT
ND
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV HLQ QSGPE LV KPGA SVKISCK ASGYGFSS SWMNWVK QRPGKGL EWIGRI YPGDGDTNYNDKFQG KATLTA DRSSST AYMHLT SLTSADS AVYFCA RS LLYSFDY WGQG TTLTVS S
D VVVT QTPLSLPVSFGD QVSISCR SSQSLAGSYGH TYLSWYLH KSGQSP QLLIYGI SNRFSGVPDRFSGSGSGT DFTLKIST IKP ED LG MYYCL QGTHQP LTF GAGT KLEL K
{'_NormalizedVDWVD1075': 71.749, '_PolarityD1075': 76.233, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.302, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.354, '_NormalizedVDWVC3': 0.256, '_HydrophobicityT23': 0.23, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 23.318, '_HydrophobicityD3050': 49.776, '_PolarityT12': 0.198, '_PolarityT13': 0.104, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 78.027, '_PolarizabilityD2050': 53.363, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 70.404, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 48.879, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 47.534, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 53.363, '_NormalizedVDWVC2': 0.35, '_PolarizabilityC2': 0.448, '_PolarizabilityC3': 0.256, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.296, '_SecondaryStrC2': 0.377, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.158, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.04, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 47.534, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.664, '_HydrophobicityD2050': 50.224, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.3, '_HydrophobicityC2': 0.386, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.176, '_PolarizabilityD3050': 47.534, '_SolventAccessibilityT13': 0.239, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.314, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 46.188, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.973, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 23.318, '_ChargeD1050': 44.395, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 69.507, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.144, '_PolarizabilityT12': 0.261, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 45.291, '_SolventAccessibilityT23': 0.185, '_ChargeC3': 0.072, '_ChargeC2': 0.825, '_ChargeC1': 0.103, '_NormalizedVDWVT23': 0.198, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 23.318, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 51.121, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.287, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.185, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 75.336, '_HydrophobicityD1050': 48.879, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.248, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 69.507, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.252, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.032, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.435, '_SolventAccessibilityC2': 0.3, '_SolventAccessibilityC3': 0.265, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.381, '_PolarityC3': 0.108, '_PolarityC2': 0.215}
25,33,50,58,96,106,117
26,37,54,57,93,102,112
30
30
350
M8a-30
Ab
SARS-CoV2_Delta
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVHLQQSGPELVKPGASVKISCKASGYGFSSSWMNWVKQRPGKGLEWIGRIYPGDGDTNYNDKFQGKATLTADRSSSTAYMHLTSLTSADSAVYFCARSLLYSFDYWGQGTTLTVSS
DVVVTQTPLSLPVSFGDQVSISCRSSQSLAGSYGHTYLSWYLHKSGQSPQLLIYGISNRFSGVPDRFSGSGSGTDFTLKISTIKPEDLGMYYCLQGTHQPLTFGAGTKLELK
IGHV1-82 (Mouse)
IGHJ2 (Mouse)
IGKV1-88 (Mouse)
IGKJ5 (Mouse)
ARSLLYSFDY
LQGTHQPLT
ND
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVQPTESIVRFPNITNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAPGQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYRYRLFRKSNLKPFERDISTEIYQAGSKPCNGVEGFNCYFPLQSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSTNLVKNKCVNF
QV HLQ QSGPE LV KPGA SVKISCK ASGYGFSS SWMNWVK QRPGKGL EWIGRI YPGDGDTNYNDKFQG KATLTA DRSSST AYMHLT SLTSADS AVYFCA RS LLYSFDY WGQG TTLTVS S
D VVVT QTPLSLPVSFGD QVSISCR SSQSLAGSYGH TYLSWYLH KSGQSP QLLIYGI SNRFSGVPDRFSGSGSGT DFTLKIST IKP ED LG MYYCL QGTHQP LTF GAGT KLEL K
{'_NormalizedVDWVD1075': 71.3, '_PolarityD1075': 76.682, '_SecondaryStrD3025': 25.561, '_PolarityD3100': 98.206, '_ChargeD1100': 98.206, '_SecondaryStrT23': 0.293, '_PolarityD3025': 17.489, '_NormalizedVDWVC1': 0.35, '_NormalizedVDWVC3': 0.265, '_HydrophobicityT23': 0.221, '_SolventAccessibilityD1025': 24.215, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.552, '_ChargeD3050': 45.74, '_PolarityD2001': 1.345, '_SolventAccessibilityD2025': 26.906, '_HydrophobicityD3050': 47.982, '_PolarityT12': 0.198, '_PolarityT13': 0.113, '_ChargeT23': 0.117, '_HydrophobicityD2100': 95.516, '_SolventAccessibilityD3001': 1.794, '_ChargeD1075': 64.574, '_SecondaryStrD1075': 74.439, '_PolarizabilityD2050': 52.018, '_SolventAccessibilityD3100': 95.516, '_PolarizabilityD1075': 68.161, '_HydrophobicityD3025': 21.973, '_PolarizabilityD3025': 22.87, '_SecondaryStrD3050': 50.673, '_SolventAccessibilityD2050': 49.327, '_HydrophobicityD2001': 1.794, '_SecondaryStrD2075': 75.336, '_PolarityD3050': 56.502, '_PolarityD1001': 0.897, '_ChargeD2075': 76.682, '_NormalizedVDWVD3025': 22.87, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.206, '_NormalizedVDWVD1001': 1.794, '_NormalizedVDWVD2050': 52.018, '_NormalizedVDWVC2': 0.345, '_PolarizabilityC2': 0.444, '_PolarizabilityC3': 0.265, '_NormalizedVDWVD3001': 0.448, '_PolarizabilityC1': 0.291, '_SecondaryStrC2': 0.372, '_SecondaryStrC3': 0.336, '_ChargeT12': 0.176, '_ChargeT13': 0.009, '_ChargeD1001': 0.448, '_ChargeD1025': 17.489, '_NormalizedVDWVD2025': 22.422, '_NormalizedVDWVD3050': 49.776, '_SecondaryStrD1025': 24.215, '_SolventAccessibilityD1050': 49.776, '_PolarizabilityD3001': 0.448, '_PolarityD2075': 77.578, '_SecondaryStrD3001': 1.794, '_ChargeD2025': 24.215, '_HydrophobicityD2050': 48.43, '_PolarizabilityD1100': 95.516, '_HydrophobicityC1': 0.309, '_HydrophobicityC2': 0.381, '_SolventAccessibilityD2100': 99.552, '_PolarizabilityD2001': 0.897, '_PolarizabilityD1025': 24.664, '_NormalizedVDWVT13': 0.185, '_PolarizabilityD3050': 49.776, '_SolventAccessibilityT13': 0.23, '_SolventAccessibilityT12': 0.288, '_PolarityD1050': 49.776, '_ChargeD3075': 65.919, '_SolventAccessibilityD1001': 0.897, '_HydrophobicityC3': 0.309, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.466, '_ChargeD3001': 2.691, '_SecondaryStrD2050': 44.843, '_PolarityD2025': 23.318, '_NormalizedVDWVD2001': 0.897, '_HydrophobicityD3075': 76.233, '_SecondaryStrD2025': 21.076, '_SolventAccessibilityD2001': 0.448, '_HydrophobicityD1025': 26.906, '_ChargeD1050': 47.534, '_SolventAccessibilityD3025': 23.767, '_PolarizabilityD3075': 71.749, '_PolarityD2100': 99.552, '_SecondaryStrD3100': 99.552, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.257, '_SecondaryStrD2001': 0.897, '_NormalizedVDWVD1050': 45.74, '_PolarizabilityD1050': 43.946, '_SolventAccessibilityT23': 0.203, '_ChargeC3': 0.072, '_ChargeC2': 0.816, '_ChargeC1': 0.112, '_NormalizedVDWVT23': 0.189, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.422, '_SolventAccessibilityD3075': 76.682, '_HydrophobicityD2075': 74.888, '_HydrophobicityD1075': 68.61, '_ChargeD2050': 50.673, '_ChargeD3100': 88.789, '_SecondaryStrC1': 0.291, '_ChargeD3025': 31.839, '_PolarityD3001': 0.448, '_PolarityD3075': 66.368, '_PolarityD1025': 22.87, '_SecondaryStrT13': 0.194, '_SecondaryStrT12': 0.243, '_HydrophobicityD1001': 0.448, '_SolventAccessibilityD1075': 76.233, '_HydrophobicityD1050': 49.327, '_HydrophobicityT13': 0.225, '_HydrophobicityT12': 0.266, '_SecondaryStrD1001': 0.448, '_NormalizedVDWVD1100': 95.516, '_NormalizedVDWVD3075': 71.749, '_NormalizedVDWVD1025': 24.664, '_SolventAccessibilityD2075': 68.61, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.094, '_NormalizedVDWVT12': 0.23, '_PolarizabilityT23': 0.248, '_SolventAccessibilityD3050': 48.43, '_PolarityT23': 0.036, '_PolarityD2050': 54.709, '_HydrophobicityD2025': 24.664, '_PolarizabilityD2075': 78.027, '_HydrophobicityD3001': 0.897, '_HydrophobicityD1100': 99.552, '_ChargeD2001': 0.897, '_SolventAccessibilityC1': 0.43, '_SolventAccessibilityC2': 0.309, '_SolventAccessibilityC3': 0.26, '_PolarizabilityD1001': 2.242, '_NormalizedVDWVD2075': 75.785, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.552, '_PolarityC1': 0.377, '_PolarityC3': 0.117, '_PolarityC2': 0.215}
25,33,50,58,96,106,117
26,37,54,57,93,102,112
31
31
352
M8a-30
Ab
WIV1
1
2
S; RBD
B-cells; Vaccinated Mouse (Mosaic RBD Nanoparticles)
QVHLQQSGPELVKPGASVKISCKASGYGFSSSWMNWVKQRPGKGLEWIGRIYPGDGDTNYNDKFQGKATLTADRSSSTAYMHLTSLTSADSAVYFCARSLLYSFDYWGQGTTLTVSS
DVVVTQTPLSLPVSFGDQVSISCRSSQSLAGSYGHTYLSWYLHKSGQSPQLLIYGISNRFSGVPDRFSGSGSGTDFTLKISTIKPEDLGMYYCLQGTHQPLTFGAGTKLELK
IGHV1-82 (Mouse)
IGHJ2 (Mouse)
IGKV1-88 (Mouse)
IGKJ5 (Mouse)
ARSLLYSFDY
LQGTHQPLT
ND
null
Chengcheng Fan et al., 2022 (https://www.biorxiv.org/content/10.1101/2022.06.28.497989v1)
2022/7/26 0:00
2022/7/26 0:00
null
Complete
RVAPSKEVVRFPNITNLCPFGEVFNATTFPSVYAWERKRISNCVADYSVLYNSTSFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFTGCVLAWNTRNIDATQTGNYNYKYRSLRHGKLRPFERDISNVPFSPDGKPCTPPAFNCYWPLNDYGFYITNGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNF
QV HLQ QSGPE LV KPGA SVKISCK ASGYGFSS SWMNWVK QRPGKGL EWIGRI YPGDGDTNYNDKFQG KATLTA DRSSST AYMHLT SLTSADS AVYFCA RS LLYSFDY WGQG TTLTVS S
D VVVT QTPLSLPVSFGD QVSISCR SSQSLAGSYGH TYLSWYLH KSGQSP QLLIYGI SNRFSGVPDRFSGSGSGT DFTLKIST IKP ED LG MYYCL QGTHQP LTF GAGT KLEL K
{'_NormalizedVDWVD1075': 71.622, '_PolarityD1075': 77.928, '_SecondaryStrD3025': 28.378, '_PolarityD3100': 97.297, '_ChargeD1100': 97.297, '_SecondaryStrT23': 0.312, '_PolarityD3025': 17.117, '_NormalizedVDWVC1': 0.383, '_NormalizedVDWVC3': 0.252, '_HydrophobicityT23': 0.253, '_SolventAccessibilityD1025': 25.225, '_PolarityD1100': 100.0, '_NormalizedVDWVD2100': 99.55, '_ChargeD3050': 45.946, '_PolarityD2001': 1.802, '_SolventAccessibilityD2025': 27.027, '_HydrophobicityD3050': 48.198, '_PolarityT12': 0.19, '_PolarityT13': 0.095, '_ChargeT23': 0.127, '_HydrophobicityD2100': 95.495, '_SolventAccessibilityD3001': 1.802, '_ChargeD1075': 63.964, '_SecondaryStrD1075': 72.072, '_PolarizabilityD2050': 52.252, '_SolventAccessibilityD3100': 95.495, '_PolarizabilityD1075': 68.018, '_HydrophobicityD3025': 22.072, '_PolarizabilityD3025': 22.973, '_SecondaryStrD3050': 50.901, '_SolventAccessibilityD2050': 49.55, '_HydrophobicityD2001': 1.351, '_SecondaryStrD2075': 76.126, '_PolarityD3050': 47.748, '_PolarityD1001': 0.901, '_ChargeD2075': 76.577, '_NormalizedVDWVD3025': 22.973, '_SolventAccessibilityD1100': 100.0, '_SecondaryStrD1100': 98.198, '_NormalizedVDWVD1001': 1.351, '_NormalizedVDWVD2050': 51.802, '_NormalizedVDWVC2': 0.324, '_PolarizabilityC2': 0.437, '_PolarizabilityC3': 0.252, '_NormalizedVDWVD3001': 0.45, '_PolarizabilityC1': 0.311, '_SecondaryStrC2': 0.387, '_SecondaryStrC3': 0.342, '_ChargeT12': 0.158, '_ChargeT13': 0.018, '_ChargeD1001': 0.45, '_ChargeD1025': 17.117, '_NormalizedVDWVD2025': 22.523, '_NormalizedVDWVD3050': 50.0, '_SecondaryStrD1025': 22.523, '_SolventAccessibilityD1050': 48.198, '_PolarizabilityD3001': 0.45, '_PolarityD2075': 75.676, '_SecondaryStrD3001': 1.802, '_ChargeD2025': 24.775, '_HydrophobicityD2050': 50.45, '_PolarizabilityD1100': 95.946, '_HydrophobicityC1': 0.288, '_HydrophobicityC2': 0.396, '_SolventAccessibilityD2100': 99.55, '_PolarizabilityD2001': 0.901, '_PolarizabilityD1025': 25.676, '_NormalizedVDWVT13': 0.195, '_PolarizabilityD3050': 50.0, '_SolventAccessibilityT13': 0.276, '_SolventAccessibilityT12': 0.271, '_PolarityD1050': 48.198, '_ChargeD3075': 66.216, '_SolventAccessibilityD1001': 0.901, '_HydrophobicityC3': 0.315, '_HydrophobicityD3100': 100.0, '_SecondaryStrD1050': 52.252, '_ChargeD3001': 3.153, '_SecondaryStrD2050': 46.396, '_PolarityD2025': 18.919, '_NormalizedVDWVD2001': 0.901, '_HydrophobicityD3075': 77.928, '_SecondaryStrD2025': 22.072, '_SolventAccessibilityD2001': 0.45, '_HydrophobicityD1025': 27.027, '_ChargeD1050': 47.748, '_SolventAccessibilityD3025': 23.874, '_PolarizabilityD3075': 69.82, '_PolarityD2100': 99.55, '_SecondaryStrD3100': 99.55, '_PolarizabilityT13': 0.149, '_PolarizabilityT12': 0.267, '_SecondaryStrD2001': 0.901, '_NormalizedVDWVD1050': 48.649, '_PolarizabilityD1050': 44.144, '_SolventAccessibilityT23': 0.176, '_ChargeC3': 0.081, '_ChargeC2': 0.82, '_ChargeC1': 0.099, '_NormalizedVDWVT23': 0.176, '_NormalizedVDWVD3100': 100.0, '_PolarizabilityD2025': 22.523, '_SolventAccessibilityD3075': 73.423, '_HydrophobicityD2075': 73.874, '_HydrophobicityD1075': 68.468, '_ChargeD2050': 50.901, '_ChargeD3100': 95.946, '_SecondaryStrC1': 0.27, '_ChargeD3025': 20.721, '_PolarityD3001': 0.45, '_PolarityD3075': 63.964, '_PolarityD1025': 22.973, '_SecondaryStrT13': 0.176, '_SecondaryStrT12': 0.217, '_HydrophobicityD1001': 0.45, '_SolventAccessibilityD1075': 77.928, '_HydrophobicityD1050': 49.55, '_HydrophobicityT13': 0.204, '_HydrophobicityT12': 0.244, '_SecondaryStrD1001': 0.45, '_NormalizedVDWVD1100': 95.946, '_NormalizedVDWVD3075': 69.82, '_NormalizedVDWVD1025': 25.676, '_SolventAccessibilityD2075': 68.468, '_SecondaryStrD2100': 100.0, '_PolarizabilityD3100': 100.0, '_SecondaryStrD3075': 73.874, '_NormalizedVDWVT12': 0.217, '_PolarizabilityT23': 0.24, '_SolventAccessibilityD3050': 50.45, '_PolarityT23': 0.041, '_PolarityD2050': 57.207, '_HydrophobicityD2025': 24.775, '_PolarizabilityD2075': 78.378, '_HydrophobicityD3001': 0.901, '_HydrophobicityD1100': 99.55, '_ChargeD2001': 0.901, '_SolventAccessibilityC1': 0.432, '_SolventAccessibilityC2': 0.288, '_SolventAccessibilityC3': 0.279, '_PolarizabilityD1001': 1.351, '_NormalizedVDWVD2075': 81.982, '_ChargeD2100': 100.0, '_PolarizabilityD2100': 99.55, '_PolarityC1': 0.383, '_PolarityC3': 0.104, '_PolarityC2': 0.203}
25,33,50,58,96,106,117
26,37,54,57,93,102,112

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