CarD-T: Carcinogen Detection via Transformers

Overview

CarD-T (Carcinogen Detection via Transformers) is a novel text analytics approach that combines transformer-based machine learning with probabilistic statistical analysis to efficiently nominate carcinogens from scientific texts. This model is designed to address the challenges faced by current systems in managing the burgeoning biomedical literature related to carcinogen identification and classification.

Model Details

Architecture: Based on Bio-ELECTRA, a 335 million parameter language model
Training Data: PubMed abstracts featuring known carcinogens from International Agency for Research on Cancer (IARC) groups G1 and G2A
Task: Named Entity Recognition (NER) for carcinogen identification
Performance:
- Precision: 0.894
- Recall: 0.857
- F1 Score: 0.875

Features

Efficient nomination of potential carcinogens from scientific literature
Context classifier to enhance accuracy and manage computational demands
Capable of identifying both chemical and non-chemical carcinogenic factors
Trained on a comprehensive dataset of carcinogen-related abstracts from 2000-2024
Recognizes named entities:
- "carcinogen" (implicated)
- "negative" (exculpated)
- "antineoplastic" (cancer protective)
- "cancertype" (additional metadata such as organism, sex, organ, and virulence)

Use Cases

Streamlining toxicogenomic literature reviews
Identifying potential carcinogens for further investigation
Augmenting existing carcinogen databases with emerging candidates

Limitations

Identifies potential candidates, not confirmed carcinogens
Analysis limited to abstract-level information
May be influenced by publication trends and research focus shifts

Deployment and Usage

Installation

To use the CarD-T model, first install the required dependencies:

pip install transformers torch

Loading the Model

from transformers import AutoTokenizer, AutoModelForTokenClassification

model_name = "jimnoneill/CarD-T"
tokenizer = AutoTokenizer.from_pretrained(model_name)
model = AutoModelForTokenClassification.from_pretrained(model_name)

Using the Model for Named Entity Recognition

def predict_entities(text):
    inputs = tokenizer(text, return_tensors="pt", truncation=True, max_length=512)
    outputs = model(**inputs)
    predictions = outputs.logits.argmax(dim=2)
    
    entities = []
    for i, pred in enumerate(predictions[0]):
        if pred != 0:  # 0 is typically the 'O' (Outside) label
            entity_type = model.config.id2label[pred.item()]
            word = tokenizer.convert_ids_to_tokens(inputs.input_ids[0][i])
            entities.append((word, entity_type))
    
    return entities

# Example usage
text = "Recent studies suggest that compound X may have antineoplastic properties in lung cancer models."
entities = predict_entities(text)
print(entities)

Full Pipeline Example

def analyze_text(text):
    entities = predict_entities(text)
    metadata = process_metadata(text)
    
    results = {
        "entities": entities,
        "metadata": metadata
    }
    
    return results

# Example usage
text = "Recent studies in male rats suggest that compound X may have antineoplastic properties in lung cancer models, while compound Y shows carcinogenic potential in liver cells."
analysis = analyze_text(text)
print(analysis)

Citation

If you use this model in your research, please cite: O'Neill, J., Reddy, G.A., Dhillon, N., Tripathi, O., Alexandrov, L., & Katira, P. (2024). CarD-T: Interpreting Carcinomic Lexicon via Transformers. MedRxiv.

License

MIT License

Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.

Contact

For questions and feedback, please contact Jamey ONeill at [email protected].