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The CSR programs are embedded into our business through several supporting working groups, including the Diversity & Inclusion Council; Environment, Health & Safety Steering Committee; Quality Council; Public Policy Committee; Illumina Cares Champions; Sustainability Green Teams; and employee resource groups (ERGs).

to Genomics We strive to remove barriers of access and increase representation of global diversity to expand the transformative benefits of genomics for all.

to Genomics, Empowering Our Communities, and Environmental Sustainability.

goals we can most uniquely impact: Our People We cultivate an agile, innovative workplace, and a culture fueled by collaboration, diversity, inclusion, and fairness.

Environmental Sustainability We invest in sustainable solutions across our facilities, supply chain, and products.

and Security Note: In this report, we use the terms “material” and “materiality” to refer to topics that reflect Illumina’s meaningful environmental, social, and governance impact.

There are still tremendous gaps in access to genomic technology, personalized medicine, and even representative data to understand genomes in the context of global diversity.

By sharing personal stories about their rare disease journey, the group is able to educate and motivate an entire ecosystem of support.

and would mean that genomes can be interpreted in the appropriate context of global diversity.

Genomics startups are playing an increasingly important role internationally in the expansion of the genomic ecosystem.

A: Embedding diversity, inclusion, and fairness in everything we do has always been a foundational priority.

We also championed a new nonprofit called SDwhich aims to support diversity in science, technology, engineering, and mathematics (STEM) education.

Our corporate giving connects to our CSR focus areas with the themes of access to genomics, diversity of genomic data, patient support, independent medical education, disaster response, and diversity.

“I got to see firsthand how our technology impacts patients, and how our giving back efforts support the community,” said Vanessa.

start in childhood Others are the result of infections (bacterial or viral), allergies and environmental causes, or are degenerative and proliferative.

We also provided a $Scripps Birch Aquarium to enable them to engage virtually with students in after-school projects that bring together ocean science, conservation, and genomics.

By understanding the marvels of nature, the power of the genetic code, and collective action, we can protect the planet that sustains us all.

The acquisitions of Edico, Enancio, and BlueBee positioned us to respond to this bottleneck as well as improve the environmental footprint.

The Enancio compression provides power-consumption savings per run, with power savings directly scaling with output capacity.

We applied multiple layers of safety measures on campus, including facility modifications, temperature screening, daily health check-ins, density limits in the labs, increased air exchange rates, workforce segregation, and enhanced sanitization to name a few.

A: We have operationalized the strategic environmental targets into site-level goals.

Our functional groups are working through a pipeline of energy-conservation projects and incorporating green design into our new construction.

We brought the Foster City, California, solar power system online and completed the first full year of operation for our California.

Even with reduced team members on-site, we completed a project in our San Diego region to convert our shuttles to electric power and continue our path to reduce our environmental footprint.

for third year in a row Focus on Environment: Overview Our Commitment We are committed to integrating environmental stewardship into the fabric of how we operate.

We recognize the importance of the environment in creating a healthy, sustainable future for our business, patients, and communities.

Our Objectives We have organized our approach to environmental sustainability by prioritizing the implementation of sustainable solutions in our facilities, our supply chain, and our products.

In progress Our Why With human health at the heart of our business, we will continue to seek opportunities for environmental protection and take action on the climate crisis.

By focusing on environmental sustainability, we foster employee engagement and drive innovation.

We do this by challenging our scientists and engineers to design new products and packaging that lower our environmental impact while unlocking the transformative power of genomics.

We are responding to climate change risk such as increased severe weather events, potential policy changes, and reputational harm by investing in more renewable energy, integrating green design principles into our facilities and products, and continuing to drive innovation.

Opportunities to support climate action through genomics research can create additional positive impacts.

We are proud to see our products being used around the world to study climate change impact, conservation biology, and influence more sustainable agriculture practices.

We believe the natural spaces in and around our sites are an extension of our working environment.

We work with experts to reduce the risk of impacting local biodiversity, closely managing protected spaces.

For example, at the San Diego headquarters we have a dedicated conservation space spanning 2.5 acres, housing an endangered species of fairy shrimp.

More than Madison site is new prairie restoration, including three water-retention ponds for stormwater deferral and trees native to the oak savannah.

OUR STORIES OF IMPACTAs part of our environmental commitment, we incorporate green building design into new construction projects and seek new ways to incorporate the natural world.

For our existing buildings, we seek initiatives to reduce our environmental footprint.

SCOPE In 2021, we plan to conduct an assessment to evaluate our Scope 3 emissions.

In our we will share targets for our holistic environmental footprint reduction.

As a result of COVID-19 and some buildings being left unoccupied with a remote workforce, we adjusted our equipment to optimize energy efficiency.

2 Scope 1 and 2 greenhouse gas emission inventory boundary defined as: sites >30,000 square feet or that contain manufacturing, distribution, or significant R&D activities.

This scope accounts for 96% of our total estimated footprint.

Our headquarter’s footprint accounts for over focus heavily on creating an impact here.

Developed by Bloom Energy, it uses solid oxide fuel cell technology to convert natural gas into electricity through a combustionfree electrochemical process.

In this technology enabled us to reduce our electricity by 80% but increased our natural gas by 111%.

The emission factors associated with an increasingly cleaner California grid resulted in a net increase of our emissions at the site.

We hope to convert the fuel cell to a renewable biofuel as innovation in the field evolves and the price of this commodity reduces to support a reasonable ROI • Conserved energy through optimization of the central plant and chilled water retrocommissioning, LED lighting, and roomoccupancy controls for lighting and HVAC • Increased efficiency with Tesla battery storage system to capture and store energy when demand is low, and discharge during peak times • Utilized the Aircuity lab management system to continuously monitor air quality throughout the day, providing demandbased ventilation to meet safety protocols.

• Participated in a two-year Strategic Energy Management (SEM) program with the California Public Utilities Commission (CPUC) and our local utility provider.

Activities included treasure hunts with our energy champion volunteers and audits with the Facilities and EHS teams, resulting in more than 100 low- (or no-)cost energysaving projects.

1 World Resources Institute water stress and the Aqueduct Project.

Water Stewardship Even though our industry is in general not water-intensive, by managing our water use, we can reduce our environmental impact and operational cost, and address potential risk that water scarcity may present.

For those identified as operating in water-stressed regions, we are committed to focusing additional efforts on water management planning.

Sustainable Supply Chain Sustainability is a strategic priority for the company, and Illumina is committed to working with suppliers that recognize the value and importance of minimizing environmental footprint.

Reducing Waste We aim to be a catalyst for positive change by addressing waste at our facilities and in our products, and encouraging our supply chain to adopt responsible policies.

Our approach to non-hazardous waste management utilizes a hierarchy where source reduction is the most preferable option, and landfill is the least preferable.

Our hazardous waste management hierarchy is designed to minimize impact and manage materials in the most environmentally responsible manner, following the hierarchy: reclamation/reuse, recycle, waste to energy recovery, fuel blending, wastewater treatment, incineration, autoclave, and landfill when other alternatives are not available.

Under the EU’s Batteries and Accumulators Directive and Packaging and Packaging Waste Directive, and regulations in several EU member states, we comply with requirements to finance the collection and recycling of batteries and packaging supplied with our products at end of life.

Growing production levels and new sites have generated increased waste, which we continuously seek to reduce.

Our Sustainability Green Teams operate at all our major sites, and represent an important and effective means to both engage with employees and enhance the sustainability of our business.

For example, our Madison team led the implementation of a project to recycle non-hazardous lab waste by glove and garment recycling through the Kimberly-Clark RightCycleTM Program.

We are committed to minimizing our environmental footprint in our supply chain by focusing on requirements upstream for our strategic suppliers and maximizing opportunities for small, diverse, and local suppliers.

We are committed to respecting and protecting the environment as we develop new products, technologies, and solutions.

We will apply the principles of environmental stewardship to address impact throughout the product life cycle.

and lower the environmental impact of products through design.

To help us evaluate differences in environmental impacts between packaging options, we have implemented a simplified life-cycle assessment (LCA) tool which enables us to make informed and evidencebased decisions about packaging materials and designs.

In progress Many of our products are temperature sensitive, which creates unique requirements for packaging, shipping, and storage.

program where returned containers are inspected, sterilized, reworked, and used again At full implementation, these containers reduce emissions by Reusable Bulk Sustainable Solutions New insulated pallet shippers are validated for multiple uses and returnable for refurbishment and reuse.

Supplier return facilities inspect and refurbish for return shipment to Illumina Pallets are modular and break down flat for easy return of multiple units via land or ocean Supports internal movement network and customer bulk orders Recyclable Insulated Containers A move to plant-based paper insulated containers results in a solution which is recyclable.

COMPARATIVE GENOMICS AND LEMUR CONSERVATION Through iConserve, a philanthropic initiative that brings the community together to accelerate wildlife conservation, the Illumina team is partnering with the San Diego Zoo, the University of Antananarivo in Madagascar, and the Universitat Pompeu Fabra in Spain to help preserve the future of several endangered creatures.

Lemurs are mammals native only to the island of Madagascar in the Indian Ocean.

The effects of widespread poverty and political instability also hinder and undermine conservation efforts.

As a result, the International Union for Conservation of Nature (IUCN) considers lemurs to be among the world’s most endangered mammals, and estimates that 90% of all lemur species are facing extinction.

The iConserve work will consist of research into the comparative genomics of lemurs, which will provide structure to cataloging biodiversity in wild and captive populations.

This will ultimately support decisions around species conservation and management.

Launched in create a digital backbone of sequences that will serve as critical infrastructure for biology, conservation, agriculture, medicine, and the growing global bioeconomy.

EBP aims to help with biodiversity and responsibly stewarding its resources.

The health of the environment and human health are intertwined and connect our company mission with our commitment to operate responsibly and sustainably.

Our technology is being used to directly support sustainability, understand climate change, study conservation, and evaluate environmental DNA.

Greater Good Initiative The Illumina Agricultural Greater Good Initiative grants, launched in annually.

While we never anticipated a crisis of this nature or scale—of a global pandemic—our culture of care foundation has been built to respond to crises as they arise.

Heading into we strived to embed diversity, inclusion, and fairness (DIF) in all we do across the organization.

This included elements of cultural competence, equal opportunity, pay equity, inclusive benefits, employee resource groups, supplier diversity, and community engagement.

As we considered how to continue our commitment to DIF in new and meaningful ways, we recognized the need for a dedicated leader who could help elevate our efforts, our thinking, and our diversity practices across the organization.

Dr. Lisa Toppin joined us in the fall as Vice President of Diversity & Inclusion.

(Black Employees Guiding Racial Empowerment and Trust) dedicated to black employees and allies, hosted diversity dialogue through company meetings, workshops, leadership forums, and guest speakers, promoted virtual courses on diversity, unconscious bias, and emotional intelligence, and increased efforts to recruit from historically black colleges and universities (HBCU).

We know the best ideas will come from a diverse, inclusive environment where everyone feels safe, respected, and supported.

To enable that environment, we offer flexible work conditions, and invest in developing employees throughout the various stages of their careers, including helping to enhance their technical, professional, and leadership skills.

We aim to create an environment that will reflect and represent the diverse communities we serve around the globe.

The collective talent, diversity, and dedication of our employees supports our mission to improve human health.

As we aim to embed diversity, inclusion, and fairness in all we do, our response to evolve our DIF strategy is integrated across the areas of our employees, our culture, our suppliers, and our community.

It includes setting new targets, investing in programs to drive improvements, and expanding transparency of our diversity data.

Culture Our employee resource groups (ERG) are key to fostering a respectful workplace and a more inclusive environment.

By connecting individuals with their peers, ERGs enable groups to develop a collective voice on shared issues and promote internal and external diversity initiatives.

We aim to provide robust diversity, inclusion, and fairness training and programming beyond the minimum required content.

CEO-driven business commitment to advance diversity and inclusion within the workplace.

By working together toward diversity and inclusion within our workplaces, industries, and the broader business community, we can cultivate meaningful change for our society.

We understand how important it is that our supply base reflects the diversity of the communities in which we live, work, and serve.

Our program, overseen by a Supplier Diversity Governance Committee, promotes partnership opportunities for suppliers in the US that are at least qualifying diverse group.