Stardrums/pico-breast-cancer · Datasets at Hugging Face

id stringlengths 1 4	tokens sequence	ner_tags sequence
1000	[ "A", "pilot", "randomized", "trial", "to", "prevent", "sexual", "dysfunction", "in", "postmenopausal", "breast", "cancer", "survivors", "starting", "adjuvant", "aromatase", "inhibitor", "therapy", ".", "A", "randomized", "pilot", "trial", "evaluated", "the", "hypothesis", "that", "early", "intervention", "lessens", "sexual", "dysfunction", "in", "the", "first", "year", "on", "aromatase", "inhibitors", ".", "A", "secondary", "aim", "was", "comparing", "the", "efficacy", "of", "two", "vaginal", "moisturizers", ".", "Fifty", "-", "seven", "postmenopausal", "women", "with", "early", "stage", "breast", "cancer", "starting", "aromatase", "inhibitors", "were", "randomized", "to", "three", "treatment", "groups", ".", "All", "received", "a", "handout", "on", "managing", "sexual", "and", "other", "side", "effects", ".", "The", "Usual", "Care", "group", "received", "no", "additional", "therapy", ".", "The", "Active", "Treatment", "groups", "received", "a", "6", "-month", "supply", "of", "a", "vaginal", "moisturizer", "(", "hyaluronic", "acid", "-", "based", "in", "Active", "Group", "-", "H", "and", "prebiotic", "in", "Active", "Group", "-", "P", ")", "and", "a", "vaginal", "lubricant", "and", "dilator", ",", "plus", "access", "to", "an", "educational", "website", "and", "phone", "coaching", ".", "Questionnaires", "completed", "at", "baseline", ",", "6", ",", "and", "12", "months", "included", "the", "Female", "Sexual", "Function", "Index", "(", "FSFI", ")", ",", "Menopausal", "Sexual", "Interest", "Questionnaire", "(", "MSIQ", ")", ",", "Female", "Sexual", "Distress", "Scale", "-", "Revised", "(", "FSDS", "-", "R", ")", ",", "and", "a", "menopausal", "symptom", "scale", ".", "Forty", "-", "nine", "women", "(", "86", "%", ")", "provided", "follow", "-", "up", "data", ".", "Mean", "age", "was", "59", "and", "77", "%", "were", "non", "-", "Hispanic", "Caucasian", ".", "Sexual", "function", "was", "impaired", "at", "baseline", ",", "but", "remained", "stable", "over", "12", "months", "for", "all", "groups", ".", "The", "combined", "active", "treatment", "group", "had", "less", "dyspareunia", "(", "P", "=", "0.07", ")", "and", "sexual", "distress", "(", "P", "=", "0.02", ")", "at", "6", "months", "than", "the", "Usual", "Care", "group", ".", "At", "6", "months", ",", "the", "Active", "-", "H", "group", "improved", "significantly", "more", "than", "the", "Active", "-", "P", "group", "on", "FSFI", "total", "score", "(", "P", "=", "0.04", ")", ".", "Sexual", "counseling", "helped", "women", "maintain", "stable", "sexual", "function", "on", "aromatase", "inhibitors", ".", "Active", "intervention", "resulted", "in", "better", "outcomes", "at", "6", "months", ".", "This", "promising", "pilot", "trial", "suggests", "a", "need", "for", "more", "research", "on", "preventive", "counseling", "to", "maintain", "sexual", "function", "during", "aromatase", "inhibitor", "treatment", "." ]	[ 0, 0, 0, 0, 0, 0, 13, 14, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 11, 12, 12, 12, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1001	[ "Fifteen", "-", "year", "results", "of", "a", "randomized", "phase", "III", "trial", "of", "fenretinide", "to", "prevent", "second", "breast", "cancer", ".", "The", "synthetic", "retinoid", "fenretinide", "administered", "for", "5", "years", "for", "prevention", "of", "second", "breast", "cancer", "showed", "no", "difference", "after", "a", "median", "of", "8", "years", ",", "but", "a", "possible", "reduction", "in", "premenopausal", "women", ".", "We", "conducted", "a", "long", "-", "term", "analysis", "in", "a", "subgroup", "of", "women", "who", "were", "regularly", "followed", "up", "in", "a", "single", "center", ".", "We", "analyzed", "data", "after", "a", "median", "follow", "-", "up", "of", "14.6", "years", "(", "IQ", "range", ",", "12.3", "-", "16.3", "years", ")", "from", "1739", "women", "aged", "30", "-", "70", "(", "872", "in", "the", "fenretinide", "arm", "and", "867", "in", "the", "observation", "arm", ")", ",", "representing", "60", "%", "of", "the", "initial", "cohort", "of", "2867", "women", ".", "The", "main", "efficacy", "endpoint", "was", "second", "primary", "breast", "cancer", "(", "contralateral", "or", "ipsilateral", ")", ".", "The", "number", "of", "second", "breast", "cancers", "was", "168", "in", "the", "fenretinide", "arm", "and", "190", "in", "the", "control", "arm", "(", "hazard", "ratio", "=", "0.83", ",", "95", "%", "CI", ",", "0.67", "-", "1.03", ")", ".", "There", "were", "83", "events", "in", "the", "fenretinide", "arm", "and", "126", "in", "the", "observation", "arm", "in", "premenopausal", "women", "(", "HR", "=", "0.62", ",", "95", "%", "CI", ",", "0.46", "-", "0.83", ")", ",", "and", "85", "and", "64", "events", "in", "postmenopausal", "women", "(", "HR", "=", "1.23", ",", "95", "%", "CI", ",", "0.63", "-", "2.40", ")", ".", "The", "younger", "were", "the", "women", ",", "the", "greater", "was", "the", "risk", "reduction", "associated", "with", "fenretinide", ",", "which", "attained", "50", "%", "in", "women", "aged", "40", "years", "or", "younger", "and", "disappeared", "after", "age", "55", "(", "P", "-", "age*treatment", "interaction", "=", "0.023", ")", ".", "There", "was", "no", "difference", "in", "cancers", "in", "other", "organs", ",", "distant", "metastases", "or", "survival", ".", "Fenretinide", "induces", "a", "significant", "risk", "reduction", "of", "second", "breast", "cancer", "in", "premenopausal", "women", ",", "which", "is", "remarkable", "at", "younger", "ages", ",", "and", "persists", "several", "years", "after", "treatment", "cessation", ".", "Since", "adverse", "events", "are", "limited", ",", "a", "trial", "in", "young", "women", "at", "high", "-", "risk", "is", "warranted", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 7, 8, 8, 8, 0, 3, 0, 0, 0, 0, 0, 5, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 24, 24, 0, 0, 21, 22, 22, 22, 22, 0, 25, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 21, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 21, 22, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1002	[ "A", "multi", "-", "center", "pragmatic", ",", "randomized", ",", "feasibility", "trial", "comparing", "standard", "of", "care", "schedules", "of", "filgrastim", "administration", "for", "primary", "febrile", "neutropenia", "prophylaxis", "in", "early", "-", "stage", "breast", "cancer", ".", "The", "most", "effective", "duration", "of", "filgrastim", "as", "primary", "febrile", "neutropenia", "(", "FN", ")", "prophylaxis", "in", "early", "breast", "cancer", "(", "EBC", ")", "patients", "is", "unknown", ".", "Despite", "significant", "differences", "in", "cost", "and", "toxicity", ",", "no", "prospective", "trial", "has", "been", "performed", "to", "optimize", "practice", ".", "We", "assessed", "the", "feasibility", "of", "using", "a", "novel", "pragmatic", "trial", "model", "to", "compare", "the", "most", "commonly", "used", "schedules", "of", "filgrastim", ".", "Early", "breast", "cancer", "patients", "receiving", "chemotherapy", "were", "randomized", "to", "5", ",", "7", ",", "or", "10", "days", "of", "filgrastim", "as", "primary", "FN", "prophylaxis", ".", "The", "trial", "methodology", "integrated", "broad", "eligibility", "criteria", ",", "simply", "defined", "endpoints", ",", "an", "integrated", "consent", "model", "incorporating", "oral", "consent", ",", "and", "web", "-", "based", "randomization", "in", "the", "clinic", ".", "Feasibility", "was", "reflected", "through", "a", "combination", "of", "primary", "endpoints", "including", "patient", "and", "physician", "engagement", "(", "if", ">", "50", "%", "of", "appropriate", "patients", "approached", "agree", "to", "participate", ",", "and", "if", ">", "50", "%", "of", "physicians", "approached", "patients", "for", "the", "study", ")", ".", "Secondary", "endpoints", "included", "the", "first", "occurrence", "rates", "of", "FN", ",", "treatment", "-", "related", "hospital", "admission", ",", "or", "chemotherapy", "dose", "reductions", "/", "delays", "/", "discontinuation", ".", "From", "May", "2015", "to", "August", "2016", ",", "142", "/", "149", "(", "95.3", "%", ")", "patients", "approached", "agreed", "to", "participate", "and", "were", "randomized", ".", "Seventeen", "of", "24", "(", "70.8", "%", ")", "medical", "oncologists", "approached", "and", "randomized", "patients", ".", "The", "142", "patients", "received", "a", "total", "of", "495", "cycles", "of", "chemotherapy", ".", "Aggregate", "incidences", "of", "a", "first", "event", "by", "patient", "were", "FN", "(", "8", "/", "142", ",", "5.6", "%", ")", ",", "treatment", "-", "related", "hospitalization", "(", "6", "/", "142", ",", "4.2", "%", ")", ",", "chemotherapy", "discontinuation", "(", "7", "/", "142", ",", "4.9", "%", ")", ",", "chemotherapy", "delays", "(", "5", "/", "142", ",", "3.5", "%", ")", ",", "and", "chemotherapy", "dose", "reduction", "(", "18", "/", "142", ",", "12.7", "%", ")", ".", "Overall", ",", "31.7", "%", "(", "45", "/", "142", ")", "of", "patients", "and", "9.0", "%", "(", "45", "/", "495", ")", "of", "chemotherapy", "cycles", "were", "associated", "with", "one", "of", "these", "first", "events", ".", "This", "study", "met", "its", "feasibility", "endpoints", ".", "This", "novel", "pragmatic", "trial", "approach", "offers", "a", "means", "of", "comparing", "standard", "of", "care", "treatments", "in", "a", "practical", "and", "cost", "-", "effective", "manner", ".", "The", "trial", "will", "now", "be", "expanded", "to", "compare", "rates", "of", "FN", "between", "the", "three", "filgrastim", "schedules", ".", "ClinicalTrials.gov", ":", "NCT", "02428114", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 0, 0, 0, 13, 14, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 21, 0, 25, 0, 1, 0, 29, 30, 0, 0, 21, 22, 22, 22, 0, 25, 0, 1, 0, 29, 30, 0, 0, 21, 22, 0, 25, 0, 1, 0, 29, 30, 0, 0, 21, 22, 0, 25, 0, 1, 0, 29, 30, 0, 0, 0, 21, 22, 22, 0, 25, 0, 1, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1003	[ "A", "phase", "II", ",", "randomized", ",", "blinded", "study", "of", "the", "farnesyltransferase", "inhibitor", "tipifarnib", "combined", "with", "letrozole", "in", "the", "treatment", "of", "advanced", "breast", "cancer", "after", "antiestrogen", "therapy", ".", "This", "study", "assessed", "the", "clinical", "efficacy", "of", "the", "farnesyltransferase", "inhibitor", ",", "tipifarnib", ",", "combined", "with", "letrozole", "in", "patients", "with", "advanced", "breast", "cancer", "and", "disease", "progression", "following", "antiestrogen", "therapy", ".", "Postmenopausal", "women", "with", "estrogen", "-", "receptor", "-", "positive", "advanced", "breast", "cancer", "that", "had", "progressed", "after", "tamoxifen", "were", "given", "2.5", "mg", "letrozole", "once", "daily", "and", "were", "randomly", "assigned", "(", "2", ":1", ")", "to", "tipifarnib", "300", "mg", "(", "TL", ")", "or", "placebo", "(", "L", ")", "twice", "daily", "for", "21", "consecutive", "days", "in", "28", "-day", "cycles", ".", "The", "primary", "endpoint", "was", "objective", "response", "rate", ".", "Of", "120", "patients", "treated", "with", "TL", "(", "n", "=", "80", ")", "or", "L", "(", "n", "=", "40", ")", ",", "113", "were", "evaluable", "for", "response", ".", "Objective", "response", "rate", "was", "30", "%", "(", "95", "%", "CI", ";", "20", "-", "41", "%", ")", "for", "TL", "and", "38", "%", "(", "95", "%", "CI", ";", "23", "-", "55", "%", ")", "for", "L", ".", "There", "was", "no", "significant", "difference", "in", "response", "duration", ",", "time", "to", "disease", "progression", "or", "survival", ".", "Clinical", "benefit", "rates", "were", "49", "%", "(", "TL", ")", "and", "62", "%", "(", "L", ")", ".", "Tipifarnib", "was", "generally", "well", "tolerated", ";", "a", "higher", "incidence", "of", "drug", "-", "related", "asymptomatic", "grade", "3", "/", "4", "neutropenia", "was", "observed", "for", "TL", "(", "18", "%", ")", "than", "for", "L", "(", "0", "%", ")", ".", "Tipifarnib", "population", "pharmacokinetics", "were", "similar", "to", "previous", "studies", ",", "with", "no", "significant", "difference", "in", "trough", "letrozole", "concentrations", "between", "the", "TL", "and", "L", "groups", ".", "Adding", "tipifarnib", "to", "letrozole", "did", "not", "improve", "objective", "response", "rate", "in", "this", "population", "of", "patients", "with", "advanced", "breast", "cancer", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 5, 0, 0, 1, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 21, 22, 22, 22, 0, 21, 0, 21, 22, 22, 22, 29, 30, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 29, 30, 0, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1004	[ "Comparing", "an", "olive", "oil", "-", "enriched", "diet", "to", "a", "standard", "lower", "-", "fat", "diet", "for", "weight", "loss", "in", "breast", "cancer", "survivors", ":", "a", "pilot", "study", ".", "Traditional", "diets", "that", "include", "moderate", "to", "high", "intakes", "of", "extra", "virgin", "olive", "oil", "have", "been", "related", "to", "a", "decrease", "in", "breast", "cancer", "risk", ".", "We", "hypothesized", "that", "an", "olive", "oil", "-", "enriched", "diet", "would", "lead", "to", "greater", "weight", "loss", "and", "acceptance", ",", "compared", "with", "a", "standard", "diet", ",", "in", "women", "previously", "diagnosed", "with", "invasive", "breast", "cancer", ".", "Participants", "consumed", "a", "National", "Cancer", "Institute", "(", "NCI", ")", "diet", "(", "total", "fat", ">", "15", "%", "and", "<", "30", "%", ")", "and", "a", "plant", "-", "based", "olive", "oil", "diet", "(", "PBOO", ";", ">", "or", "=", "3", "tablespoons", "of", "olive", "oil", "/", "day", ")", "for", "8", "weeks", ",", "each", "with", "random", "assignment", "to", "the", "order", ".", "We", "established", "a", "weight", "loss", "goal", "of", "at", "least", "5", "%", "of", "baseline", "weight", ".", "After", "completion", "of", "the", "two", "diet", "trials", ",", "each", "participant", "self", "-", "selected", "one", "of", "the", "diets", "for", "an", "additional", "6", "months", "of", "follow", "-", "up", "for", "weight", "management", ".", "Body", "measures", "were", "done", "before", "and", "after", "each", "diet", "and", "after", "follow", "-", "up", ";", "fasting", "blood", "samples", "were", "collected", "after", "each", "diet", "and", "after", "follow", "-", "up", ".", "Forty", "-", "four", "overweight", "women", "started", "and", "28", "completed", "the", "44", "-week", "protocol", ".", "Twelve", "(", "80", "%", ")", "of", "the", "15", "women", "who", "started", "with", "the", "PBOO", "diet", "achieved", "a", "weight", "loss", "of", ">", "or", "=", "5", "%", "compared", "to", "4", "(", "31", "%", ")", "of", "the", "13", "who", "started", "with", "the", "NCI", "diet", "(", "p", "<", "0.01", ")", ".", "Nineteen", "of", "the", "22", "women", "eligible", "for", "follow", "-", "up", "chose", "the", "PBOO", "diet", ",", "and", "all", "completed", "the", "study", ".", "Of", "the", "3", "women", "who", "chose", "the", "NCI", "diet", "for", "follow", "-", "up", ",", "1", "completed", "the", "study", ".", "The", "PBOO", "diet", "resulted", "in", "lower", "triglycerides", "(", "NCI", "105", "+", "/-", "46", "mg", "/", "dL", ",", "PBOO", "96", "+", "/-", "37", "mg", "/", "dL", ",", "p", "=", "0.06", ")", "and", "higher", "high", "-", "density", "lipoprotein", "cholesterol", "(", "HDL", "-", "C", ")", "(", "NCI", "64", "+", "/-", "13", "mg", "/", "dL", ",", "PBOO", "68", "+", "/-", "12", "mg", "/", "dL", ",", "p", "=", "0.001", ")", ".", "An", "olive", "oil", "-", "enriched", "diet", "brought", "about", "greater", "weight", "loss", "than", "a", "lower", "-", "fat", "diet", "in", "an", "8", "-week", "comparison", ".", "Moreover", ",", "these", "women", "chose", ",", "overwhelmingly", ",", "the", "olive", "oil", "-", "enriched", "diet", "for", "6", "months", "of", "follow", "-", "up", ".", "An", "olive", "oil", "-", "enriched", "diet", "may", "be", "more", "efficacious", "for", "weight", "loss", "in", "breast", "cancer", "survivors", "than", "a", "standard", "lower", "-", "fat", "diet", "." ]	[ 0, 0, 17, 18, 18, 18, 18, 0, 0, 19, 20, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 25, 0, 29, 30, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 22, 22, 0, 0, 27, 0, 31, 32, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 35, 0, 0, 43, 44, 44, 44, 0, 0, 33, 0, 0, 41, 42, 42, 42, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 35, 0, 0, 43, 44, 44, 44, 0, 0, 33, 0, 0, 41, 42, 42, 42, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1005	[ "[", "A", "pilot", "study", "of", "weekly", "versus", "3", "-week", "docetaxel", "in", "combination", "with", "capecitabine", "in", "patients", "with", "anthracycline", "-", "pretreated", "metastatic", "breast", "cancer", "]", ".", "To", "evaluate", "the", "efficacy", "and", "safety", "of", "weekly", "or", "3", "-week", "docetaxel", "in", "combination", "with", "capecitabine", ".", "83", "Patients", "with", "at", "least", "one", "measurable", "lesion", "were", "randomized", "to", "receive", "the", "treatment", "arms", ":", "docetaxel", "37.5", "mg", "/", "m", "(", "2", ")", "on", "days", "1", "and", "8", ",", "oral", "capecitabine", "950", "mg", "/", "m", "(", "2", ")", "twice", "daily", "on", "days", "1", "-", "14", "(", "Group", "A", ")", ";", "docetaxel", "75", "mg", "/", "m", "(", "2", ")", "on", "days", "1", ",", "oral", "capecitabine", "950", "mg", "/", "m", "(", "2", ")", "twice", "daily", "on", "days", "1", "-", "14", "(", "Group", "B", ")", ".", "Each", "cycle", "was", "repeated", "every", "3", "weeks", ".", "Eighty", "-", "three", "patients", "were", "enrolled", ",", "78", "eligible", "for", "tumor", "assessment", ".", "The", "overall", "clinical", "response", "rate", "of", "all", "groups", "was", "61.4", "%", "(", "51", "/", "83", ")", ".", "There", "was", "no", "progressive", "disease", "(", "PD", ")", "after", "two", "cycles", ".", "Efficacy", "outcomes", "were", "similar", "in", "the", "two", "groups", ".", "The", "response", "rate", "of", "group", "A", "and", "B", "were", "61.8", "%", "(", "21", "/", "34", ")", "and", "61.2", "%", "(", "30", "/", "49", ")", "respectively", ".", "There", "were", "no", "drug", "-", "related", "deaths", "observed", ".", "Neutropenia", "was", "the", "most", "common", "toxicity", ".", "In", "all", ",", "the", "frequency", "of", "Grade", "3", "/", "4", "neutropenia", "were", "45.8", "%", "(", "38", "/", "83", ")", ",", "but", "Grade", "3", "/", "4", "neutropenia", "of", "Group", "B", "55.1", "%", "(", "27", "/", "49", ")", "was", "higher", "than", "Group", "A", "32.4", "%", "(", "11", "/", "34", ")", ",", "P", "=", "0.04", ".", "The", "study", "confirmed", "the", "superior", "activity", "of", "docetaxe", "-", "capecitabine", "combination", "therapy", "in", "anthracycline", "resistant", "MBC", ",", "and", "comparing", "with", "3", "-week", "schedule", ",", "weekly", "docetaxel", "plus", "capecitabine", "has", "same", "high", "efficacy", "with", "a", "favourable", "safety", "profile", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 29, 30, 0, 25, 0, 3, 0, 0, 31, 32, 0, 27, 0, 5, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 31, 32, 0, 27, 0, 5, 0, 0, 0, 0, 0, 0, 29, 30, 0, 25, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1006	[ "Phase", "III", "randomized", "equivalence", "trial", "of", "early", "breast", "cancer", "treatments", "with", "or", "without", "axillary", "clearance", "in", "post", "-", "menopausal", "patients", "results", "after", "5", "years", "of", "follow", "-", "up", ".", "Axillary", "lymph", "node", "clearance", "(", "ALNC", ")", "improves", "locoregional", "control", "and", "provides", "prognostic", "information", "for", "early", "breast", "cancer", "treatment", ",", "but", "effects", "on", "survival", "are", "controversial", ".", "This", "multicentre", ",", "randomized", "pragmatic", "equivalence", "trial", "compares", "outcomes", "for", "post", "-", "menopausal", "early", "invasive", "breast", "cancer", "patients", "after", "locoregional", "treatment", "with", "ALNC", "and", "adjuvant", "therapies", "to", "outcomes", "after", "locoregional", "treatment", "without", "ALNC", "and", "adjuvant", "therapies", ".", "From", "1995", "-", "2005", ",", "women", "aged", "≥", "50", "years", "with", "early", "breast", "cancer", "(", "tumor", "≤", "10", "mm", ")", "and", "clinically", "-", "negative", "axillary", "nodes", "were", "randomized", "to", "receive", "treatment", "with", "ALNC", "(", "Ax", ")", "or", "without", "(", "no", "-", "Ax", ")", ".", "Adjuvant", "therapies", "were", "prescribed", "according", "to", "hormonal", "receptor", "status", "and", "individual", "histological", "results", ".", "The", "primary", "endpoint", "was", "overall", "survival", "(", "OS", ")", ";", "secondary", "endpoints", "were", "event", "-", "free", "survival", "(", "EFS", ")", "and", "functional", "outcomes", ".", "The", "trial", "was", "terminated", "due", "to", "lack", "of", "equivalence", "and", "low", "accrual", "after", "first", "interim", "analyses", ".", "NCT", "00210236", ".", "Of", "625", "patients", ",", "297", "no", "-", "Ax", "and", "310", "Ax", "patients", "were", "maintained", "for", "final", "per", "-", "protocol", "analyses", ".", "OS", "and", "EFS", "at", "five", "years", "were", "not", "equivalent", "(", "Ax", "vs.", "no", "-", "Ax", ":", "98", "%", "vs.", "94", "%", "and", "96", "%", "vs.", "90", "%", "respectively", ")", ".", "Recurrence", "was", "higher", "for", "no", "-", "Ax", ",", "particularly", "in", "the", "first", "five", "years", "after", "surgery", ".", "Axillary", "nodes", "were", "positive", "for", "14", "%", "Ax", "patients", "but", "only", "2", "%", "no", "-", "Ax", "patients", "experienced", "axillary", "node", "recurrence", ".", "Functional", "impairments", "were", "greater", "after", "ALNC", ".", "Our", "results", "fail", "to", "demonstrate", "equivalence", "of", "outcomes", "when", "ALNC", "is", "omitted", "from", "post", "-", "menopausal", "early", "breast", "cancer", "patient", "treatment", ".", "However", "the", "low", "locoregional", "recurrence", "rates", "warrant", "further", "examination", "over", "a", "longer", "duration", ",", "in", "particular", "to", "consider", "whether", "these", "would", "impact", "on", "survival", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 23, 24, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 5, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 29, 30, 0, 31, 32, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 29, 30, 0, 0, 0, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1007	[ "Pectoral", "nerve", "blocks", "to", "improve", "analgesia", "after", "breast", "cancer", "surgery", ":", "A", "prospective", ",", "randomized", "and", "controlled", "trial", ".", "To", "evaluate", "the", "analgesic", "efficacy", "of", "ultrasound", "guided", "combined", "pectoral", "nerve", "blocks", "I", "and", "II", "in", "patients", "scheduled", "for", "surgery", "for", "breast", "cancer", ".", "Prospective", ",", "randomized", ",", "control", "trial", ".", "Operating", "rooms", "in", "a", "tertiary", "care", "hospital", "of", "Northern", "India", ".", "Sixty", "American", "Society", "of", "Anesthesiologists", "status", "I", "to", "II", "adult", "women", ",", "aged", "18", "-", "70", "years", "were", "enrolled", "in", "this", "study", ".", "Patients", "were", "randomized", "into", "two", "groups", "(", "30", "patients", "in", "each", "group", ")", ",", "PECS", "(", "P", ")", "group", "and", "control", "(", "C", ")", "group", ".", "In", "group", "P", ",", "patients", "received", "both", "general", "anesthesia", "and", "ultrasound", "guided", "combined", "pectoral", "nerve", "blocks", "(", "PECS", "I", "and", "II", ")", ".", "In", "group", "C", ",", "patients", "received", "only", "general", "anesthesia", ".", "We", "noted", "pain", "intensity", "at", "rest", "and", "during", "abduction", "of", "the", "ipsilateral", "upper", "limb", ",", "incidence", "of", "postoperative", "nausea", "and", "vomiting", ";", "patient", "'s", "satisfaction", "with", "postoperative", "analgesia", "and", "maximal", "painless", "abduction", "at", "different", "time", "intervals", "in", "both", "groups", ".", "There", "was", "significant", "decrease", "in", "the", "total", "amount", "of", "fentanyl", "requirement", "in", "the", "in", "P", "group", "{", "(", "140.66", "±", "31.80", "μg", ")", "and", "(", "438", "±", "71.74", "μg", ")", "}", "in", "comparison", "to", "C", "group", "{", "(", "218.33", "±", "23.93", "μg", ")", "and", "(", "609", "±", "53.00", "μg", ")", "}", "during", "intraoperative", "and", "post", "-", "operative", "period", "upto", "24", "h", "respectively", ".", "The", "time", "to", "first", "analgesic", "requirement", "was", "also", "more", "in", "P", "group", "(", "44.33", "±", "17.65", "min", ")", "in", "comparison", "to", "C", "group", "(", "10.36", "±", "4.97", "min", ")", "during", "post", "-", "operative", "period", ".", "There", "was", "less", "limitation", "of", "shoulder", "movement", "(", "pain", "free", "mobilization", ")", "on", "the", "operative", "site", "at", "4", "h", "and", "5", "h", "after", "surgery", "in", "P", "group", "in", "comparison", "to", "C", "group", ".", "However", "there", "was", "no", "difference", "in", "the", "incidence", "of", "post", "-", "operative", "nausea", "and", "vomiting", "(", "22", "out", "of", "30", "patients", "in", "group", "P", "and", "20", "out", "of", "30", "patients", "in", "group", "C", ")", "but", "patients", "in", "group", "P", "had", "a", "better", "satisfaction", "score", "with", "postoperative", "analgesia", "than", "C", "group", "having", "a", "p", "value", "of", "<", "0.001", "(", "Score", "1", ";", "5", "VS", "20", ";", "Score", "2", ";", "12", "VS", "9", ";", "Score", "3", ";", "13", "VS", "1", ")", ".", "Ultrasound", "guided", "combined", "pectoral", "nerve", "blocks", "are", "an", "effective", "modality", "of", "analgesia", "for", "patients", "undergoing", "breast", "surgeries", "during", "perioperative", "period", ".", "CTRI", "/", "2015", "/", "12", "/", "006457", "." ]	[ 17, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 33, 0, 41, 42, 0, 0, 0, 33, 0, 41, 42, 0, 0, 0, 0, 0, 0, 0, 0, 0, 35, 0, 43, 44, 0, 0, 0, 35, 0, 43, 44, 0, 0, 0, 21, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 33, 0, 41, 42, 0, 0, 0, 0, 0, 0, 0, 35, 0, 43, 44, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 22, 22, 22, 0, 25, 0, 0, 3, 0, 0, 0, 0, 0, 27, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 25, 0, 27, 0, 21, 22, 0, 25, 0, 27, 0, 21, 22, 0, 25, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1008	[ "Sentinel", "node", "biopsy", "in", "breast", "cancer", ":", "validation", "study", "and", "comparison", "of", "blue", "dye", "alone", "with", "triple", "modality", "localization", ".", "Sentinel", "node", "biopsy", "(", "SNB", ")", "for", "breast", "cancer", "patients", "is", "a", "new", "technique", "with", "the", "potential", "to", "provide", "an", "accurate", "staging", "of", "the", "axillary", "nodal", "status", "while", "avoiding", "the", "morbidity", "of", "an", "axillary", "dissection", ".", "The", "objective", "of", "the", "present", "study", "is", "to", "validate", "the", "use", "of", "sentinel", "node", "biopsy", "in", "a", "New", "Zealand", "hospital", "and", "to", "compare", "the", "ability", "of", "patent", "blue", "dye", "(", "PB", ")", "alone", "with", "triple", "modality", "(", "TM", ")", "(", "preoperative", "lymphoscintigraphy", ",", "intraoperative", "gamma", "probe", "and", "intraoperative", "blue", "dye", ")", "to", "identify", "the", "sentinel", "node", ".", "A", "total", "of", "104", "patients", "who", "had", "a", "palpable", "breast", "lump", "that", "was", "confirmed", "to", "be", "malignant", "by", "radiology", "and", "cytology", "and", "a", "clinical", "diagnosis", "of", "stage", "I", "or", "stage", "II", "breast", "cancer", ",", "were", "enrolled", "for", "SNB", "and", "randomly", "assigned", "to", "triple", "modality", "or", "blue", "dye", "alone", "for", "the", "localization", "of", "the", "sentinel", "node", ".", "Axillary", "dissection", "was", "performed", "after", "the", "sentinel", "node", "(", "s", ")", "had", "been", "removed", ".", "There", "were", "63", "patients", "in", "the", "PB", "group", "and", "41", "patients", "in", "the", "TM", "group", ".", "Both", "groups", "are", "comparable", ",", "with", "a", "similar", "mean", "age", "and", "primary", "tumour", "size", ".", "A", "sentinel", "node", "was", "identified", "in", "57", "(", "90", "%", ")", "of", "the", "PB", "group", "patients", "and", "40", "(", "98", "%", ")", "of", "the", "TM", "group", "patients", ".", "Of", "these", "23", "(", "37", "%", ")", "of", "the", "PB", "group", "and", "23", "(", "56", "%", ")", "in", "the", "TM", "group", "had", "axillary", "nodes", "positive", "for", "malignancy", ".", "There", "was", "one", "false", "negative", "SNB", "in", "the", "PB", "group", "and", "two", "false", "negative", "results", "in", "the", "TM", "group", ".", "Therefore", ",", "the", "PB", "group", "had", "an", "accuracy", "of", "98", "%", "and", "a", "sensitivity", "of", "96", "%", "compared", "to", "an", "accuracy", "of", "95", "%", "and", "a", "sensitivity", "of", "91", "%", "for", "the", "TM", "group", ".", "The", "results", "of", "the", "present", "study", "validate", "the", "use", "of", "SNB", "in", "suitable", "breast", "cancer", "patients", ".", "Identification", "and", "the", "accuracy", "of", "the", "sentinel", "node", "localization", "were", "similar", "between", "the", "two", "groups", ".", "Therefore", ",", "in", "hospital", "centres", "without", "adequate", "access", "to", "a", "nuclear", "medical", "facility", ",", "it", "would", "be", "feasible", "to", "conduct", "SNB", "using", "blue", "dye", "alone", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 16, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 9, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 25, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 27, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 25, 0, 29, 30, 0, 0, 0, 0, 0, 0, 27, 0, 31, 32, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 22, 0, 0, 0, 25, 21, 22, 22, 0, 0, 0, 0, 0, 27, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 29, 30, 0, 0, 21, 0, 31, 32, 0, 0, 0, 21, 0, 31, 32, 0, 0, 21, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1009	[ "Epirubicin", "-", "based", "chemotherapy", "as", "adjuvant", "treatment", "for", "poor", "prognosis", ",", "node", "-", "negative", "breast", "cancer", ":", "10", "-year", "follow", "-", "up", "results", "of", "the", "French", "Adjuvant", "Study", "Group", "03", "trial", ".", "We", "evaluated", "the", "contribution", "of", "an", "epirubicin", "-", "based", "adjuvant", "chemotherapy", "on", "disease", "-", "free", "survival", "(", "DFS", ")", "in", "poor", "prognosis", ",", "node", "-", "negative", "breast", "cancer", "(", "BC", ")", "patients", ".", "Poor", "prognostic", "factors", "were", "defined", "as", ":", "pathologic", "tumor", "size", ">", "or=", "4", "cm", ",", "estrogen", "-", "receptor", "negative", ",", "and", "progesterone", "-", "receptor", "negative", ".", "Scarff", "-", "Bloom", "Richardson", "grade", "2", "tumors", "must", "have", "two", "of", "these", "factors", ",", "and", "only", "one", "in", "case", "of", "grade", "3", ".", "Between", "1988", "and", "1994", ",", "328", "patients", "were", "randomized", "to", "receive", "either", "no", "systemic", "treatment", "(", "control", ",", "n", "=", "161", ")", ",", "or", "fluorouracil", "500", "mg", "/", "m", "(", "2", ")", ",", "epirubicin", "50", "mg", "/", "m", "(", "2", ")", ",", "cyclophosphamide", "500", "mg", "/", "m", "(", "2", ")", ",", "6", "cycles", "every", "21", "days", "(", "FEC", "50", ",", "n", "=", "167", ")", ",", "without", "any", "hormonal", "treatment", ".", "The", "median", "follow", "up", "was", "114", "months", ".", "The", "10", "-year", "DFS", "rates", "were", "64", "and", "71", "%", ",", "respectively", "(", "p", "=", "0.23", ")", ".", "In", "the", "Cox", "regression", "model", ",", "independent", "prognostic", "factors", "of", "relapse", "were", "the", "number", "of", "nodes", "examined", "<", "10", "(", "p", "=", "0.002", ")", ",", "BCS", "(", "p", "=", "0.01", ")", ",", "and", "premenopausal", "status", "(", "p", "=", "0.04", ")", ".", "In", "this", "model", ",", "the", "relative", "risk", "of", "relapse", "was", "1.46", "(", "CI", "95", "%", ":", "1.05", "-", "1.87", ")", "in", "favor", "of", "FEC", "50", ".", "In", "patients", "who", "underwent", "BCS", ",", "21", "%", "developed", "a", "local", "relapse", "(", "24", "versus", "18", "%", ",", "respectively", ")", ".", "The", "10", "-year", "local", "DFS", "was", "70.5", "and", "79.3", "%", ",", "respectively", "(", "p", "=", "0.27", ")", ".", "The", "10", "-year", "overall", "survival", "was", "not", "different", "(", "74.1", "versus", "70.7", "%", ",", "p", "=", "0.82", ")", ".", "After", "10", "years", "of", "follow", "-", "up", ",", "the", "FEC", "50", "regimen", "reduced", "the", "risk", "of", "relapse", "in", "poor", "-", "prognosis", "node", "-", "negative", "BC", "patients", ".", "The", "incidence", "of", "local", "relapse", "was", "high", ",", "and", "probably", "related", "to", "inclusion", "criteria", ".", "Epirubicin", "was", "probably", "underdosed", "in", "such", "patients", ",", "and", "ongoing", "studies", "using", "100", "mg", "/", "m", "(", "2", ")", "of", "epirubicin", "will", "give", "us", "the", "answer", "in", "a", "near", "future", "." ]	[ 17, 18, 18, 18, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 19, 20, 20, 20, 20, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 31, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 31, 0, 29, 30, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 31, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 31, 0, 29, 30, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]
1010	[ "Better", "pathologic", "complete", "response", "and", "relapse", "-", "free", "survival", "after", "carboplatin", "plus", "paclitaxel", "compared", "with", "epirubicin", "plus", "paclitaxel", "as", "neoadjuvant", "chemotherapy", "for", "locally", "advanced", "triple", "-", "negative", "breast", "cancer", ":", "a", "randomized", "phase", "2", "trial", ".", "No", "standard", "chemotherapy", "is", "used", "as", "neoadjuvant", "therapy", "in", "triple", "negative", "breast", "cancer", "(", "TNBC", ")", ".", "This", "study", "has", "compared", "carboplatin", "plus", "paclitaxel", "with", "commonly", "used", "epirubicin", "plus", "paclitaxel", "as", "neoadjuvant", "chemotherapy", "(", "NAC", ")", "in", "TNBC", ".", "91", "patients", "with", "a", "median", "age", "of", "47", "years", "(", "PC", "47", "patients", ",", "EP", "44", "patients", ")", "were", "enrolled", ".", "65", "%", "of", "the", "patients", "were", "premenopausal", ".", "While", "the", "objective", "response", "rate", "was", "similar", "in", "the", "PC", "and", "EP", "arm", "(", "89.4", "%", "vs.", "79.5", "%", ",", "P", "=", "0.195", ")", ",", "the", "pCR", "rate", "in", "the", "PC", "arm", "was", "significantly", "higher", "(", "38.6", "%", "vs.", "14.0", "%", ",", "P", "=", "0.014", ")", ".", "The", "median", "follow", "-", "up", "time", "was", "55.0", "months", ".", "5", "-year", "RFS", "were", "77.6", "%", "and", "56.2", "%", ",", "significantly", "higher", "in", "the", "PC", "arm", ",", "P", "=", "0.043", ".", "No", "significant", "difference", "in", "OS", "was", "observed", "between", "the", "two", "arms", "(", "P", "=", "0.350", ")", ".", "Adverse", "events", "were", "similar", ",", "except", "for", "more", "thrombocytopenia", "in", "the", "PC", "arm", "(", "P", "=", "0.001", ")", ".", "Patients", "with", "stage", "II", "/", "III", "TNBC", "were", "randomized", "to", "receive", "either", "paclitaxel", "(", "175", "mg", "/", "m", "2", ",", "day", "1", ")", "plus", "carboplatin", "(", "Area", "Under", "the", "Curve", "=", "5", ",", "day", "2", ")", "(", "PC", ")", "or", "epirubicin", "(", "75", "mg", "/", "m", "2", ",", "day", "1", ")", "plus", "paclitaxel", "(", "175", "mg", "/", "m", "2", ",", "day", "2", ")", "(", "EP", ")", "as", "NAC", "every", "three", "weeks", "for", "4", "-", "6", "cycles", ".", "The", "primary", "endpoint", "was", "rate", "of", "pathologic", "complete", "response", "(", "pCR", ")", ".", "The", "secondary", "endpoints", "included", "relapse", "-", "free", "survival", "(", "RFS", ")", ",", "overall", "survival", "(", "OS", ")", "and", "safety", ".", "This", "study", "suggested", "that", "the", "addition", "of", "carboplatin", "to", "paclitaxel", "was", "superior", "to", "the", "regimen", "of", "epirubicin", "plus", "paclitaxel", "as", "NAC", "for", "TNBC", "in", "terms", "of", "improving", "pCR", "rate", "and", "RFS", ".", "Further", "phase", "3", "study", "has", "already", "started", "." ]	[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 17, 18, 18, 0, 0, 19, 20, 20, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 21, 22, 0, 0, 0, 0, 0, 0, 0, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 0, 29, 30, 0, 31, 32, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 10, 10, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 0, 0, 0, 0, 0, 23, 24, 24, 24, 24, 24, 24, 0, 23, 24, 24, 24, 24, 0, 23, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 21, 22, 22, 22, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

1000

[ "A", "pilot", "randomized", "trial", "to", "prevent", "sexual", "dysfunction", "in", "postmenopausal", "breast", "cancer", "survivors", "starting", "adjuvant", "aromatase", "inhibitor", "therapy", ".", "A", "randomized", "pilot", "trial", "evaluated", "the", "hypothesis", "that", "early", "intervention", "lessens", "sexual", "dysfunction", "in", "the", "first", "year", "on", "aromatase", "inhibitors", ".", "A", "secondary", "aim", "was", "comparing", "the", "efficacy", "of", "two", "vaginal", "moisturizers", ".", "Fifty", "-", "seven", "postmenopausal", "women", "with", "early", "stage", "breast", "cancer", "starting", "aromatase", "inhibitors", "were", "randomized", "to", "three", "treatment", "groups", ".", "All", "received", "a", "handout", "on", "managing", "sexual", "and", "other", "side", "effects", ".", "The", "Usual", "Care", "group", "received", "no", "additional", "therapy", ".", "The", "Active", "Treatment", "groups", "received", "a", "6", "-month", "supply", "of", "a", "vaginal", "moisturizer", "(", "hyaluronic", "acid", "-", "based", "in", "Active", "Group", "-", "H", "and", "prebiotic", "in", "Active", "Group", "-", "P", ")", "and", "a", "vaginal", "lubricant", "and", "dilator", ",", "plus", "access", "to", "an", "educational", "website", "and", "phone", "coaching", ".", "Questionnaires", "completed", "at", "baseline", ",", "6", ",", "and", "12", "months", "included", "the", "Female", "Sexual", "Function", "Index", "(", "FSFI", ")", ",", "Menopausal", "Sexual", "Interest", "Questionnaire", "(", "MSIQ", ")", ",", "Female", "Sexual", "Distress", "Scale", "-", "Revised", "(", "FSDS", "-", "R", ")", ",", "and", "a", "menopausal", "symptom", "scale", ".", "Forty", "-", "nine", "women", "(", "86", "%", ")", "provided", "follow", "-", "up", "data", ".", "Mean", "age", "was", "59", "and", "77", "%", "were", "non", "-", "Hispanic", "Caucasian", ".", "Sexual", "function", "was", "impaired", "at", "baseline", ",", "but", "remained", "stable", "over", "12", "months", "for", "all", "groups", ".", "The", "combined", "active", "treatment", "group", "had", "less", "dyspareunia", "(", "P", "=", "0.07", ")", "and", "sexual", "distress", "(", "P", "=", "0.02", ")", "at", "6", "months", "than", "the", "Usual", "Care", "group", ".", "At", "6", "months", ",", "the", "Active", "-", "H", "group", "improved", "significantly", "more", "than", "the", "Active", "-", "P", "group", "on", "FSFI", "total", "score", "(", "P", "=", "0.04", ")", ".", "Sexual", "counseling", "helped", "women", "maintain", "stable", "sexual", "function", "on", "aromatase", "inhibitors", ".", "Active", "intervention", "resulted", "in", "better", "outcomes", "at", "6", "months", ".", "This", "promising", "pilot", "trial", "suggests", "a", "need", "for", "more", "research", "on", "preventive", "counseling", "to", "maintain", "sexual", "function", "during", "aromatase", "inhibitor", "treatment", "." ]

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1001

[ "Fifteen", "-", "year", "results", "of", "a", "randomized", "phase", "III", "trial", "of", "fenretinide", "to", "prevent", "second", "breast", "cancer", ".", "The", "synthetic", "retinoid", "fenretinide", "administered", "for", "5", "years", "for", "prevention", "of", "second", "breast", "cancer", "showed", "no", "difference", "after", "a", "median", "of", "8", "years", ",", "but", "a", "possible", "reduction", "in", "premenopausal", "women", ".", "We", "conducted", "a", "long", "-", "term", "analysis", "in", "a", "subgroup", "of", "women", "who", "were", "regularly", "followed", "up", "in", "a", "single", "center", ".", "We", "analyzed", "data", "after", "a", "median", "follow", "-", "up", "of", "14.6", "years", "(", "IQ", "range", ",", "12.3", "-", "16.3", "years", ")", "from", "1739", "women", "aged", "30", "-", "70", "(", "872", "in", "the", "fenretinide", "arm", "and", "867", "in", "the", "observation", "arm", ")", ",", "representing", "60", "%", "of", "the", "initial", "cohort", "of", "2867", "women", ".", "The", "main", "efficacy", "endpoint", "was", "second", "primary", "breast", "cancer", "(", "contralateral", "or", "ipsilateral", ")", ".", "The", "number", "of", "second", "breast", "cancers", "was", "168", "in", "the", "fenretinide", "arm", "and", "190", "in", "the", "control", "arm", "(", "hazard", "ratio", "=", "0.83", ",", "95", "%", "CI", ",", "0.67", "-", "1.03", ")", ".", "There", "were", "83", "events", "in", "the", "fenretinide", "arm", "and", "126", "in", "the", "observation", "arm", "in", "premenopausal", "women", "(", "HR", "=", "0.62", ",", "95", "%", "CI", ",", "0.46", "-", "0.83", ")", ",", "and", "85", "and", "64", "events", "in", "postmenopausal", "women", "(", "HR", "=", "1.23", ",", "95", "%", "CI", ",", "0.63", "-", "2.40", ")", ".", "The", "younger", "were", "the", "women", ",", "the", "greater", "was", "the", "risk", "reduction", "associated", "with", "fenretinide", ",", "which", "attained", "50", "%", "in", "women", "aged", "40", "years", "or", "younger", "and", "disappeared", "after", "age", "55", "(", "P", "-", "age*treatment", "interaction", "=", "0.023", ")", ".", "There", "was", "no", "difference", "in", "cancers", "in", "other", "organs", ",", "distant", "metastases", "or", "survival", ".", "Fenretinide", "induces", "a", "significant", "risk", "reduction", "of", "second", "breast", "cancer", "in", "premenopausal", "women", ",", "which", "is", "remarkable", "at", "younger", "ages", ",", "and", "persists", "several", "years", "after", "treatment", "cessation", ".", "Since", "adverse", "events", "are", "limited", ",", "a", "trial", "in", "young", "women", "at", "high", "-", "risk", "is", "warranted", "." ]

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1002

[ "A", "multi", "-", "center", "pragmatic", ",", "randomized", ",", "feasibility", "trial", "comparing", "standard", "of", "care", "schedules", "of", "filgrastim", "administration", "for", "primary", "febrile", "neutropenia", "prophylaxis", "in", "early", "-", "stage", "breast", "cancer", ".", "The", "most", "effective", "duration", "of", "filgrastim", "as", "primary", "febrile", "neutropenia", "(", "FN", ")", "prophylaxis", "in", "early", "breast", "cancer", "(", "EBC", ")", "patients", "is", "unknown", ".", "Despite", "significant", "differences", "in", "cost", "and", "toxicity", ",", "no", "prospective", "trial", "has", "been", "performed", "to", "optimize", "practice", ".", "We", "assessed", "the", "feasibility", "of", "using", "a", "novel", "pragmatic", "trial", "model", "to", "compare", "the", "most", "commonly", "used", "schedules", "of", "filgrastim", ".", "Early", "breast", "cancer", "patients", "receiving", "chemotherapy", "were", "randomized", "to", "5", ",", "7", ",", "or", "10", "days", "of", "filgrastim", "as", "primary", "FN", "prophylaxis", ".", "The", "trial", "methodology", "integrated", "broad", "eligibility", "criteria", ",", "simply", "defined", "endpoints", ",", "an", "integrated", "consent", "model", "incorporating", "oral", "consent", ",", "and", "web", "-", "based", "randomization", "in", "the", "clinic", ".", "Feasibility", "was", "reflected", "through", "a", "combination", "of", "primary", "endpoints", "including", "patient", "and", "physician", "engagement", "(", "if", ">", "50", "%", "of", "appropriate", "patients", "approached", "agree", "to", "participate", ",", "and", "if", ">", "50", "%", "of", "physicians", "approached", "patients", "for", "the", "study", ")", ".", "Secondary", "endpoints", "included", "the", "first", "occurrence", "rates", "of", "FN", ",", "treatment", "-", "related", "hospital", "admission", ",", "or", "chemotherapy", "dose", "reductions", "/", "delays", "/", "discontinuation", ".", "From", "May", "2015", "to", "August", "2016", ",", "142", "/", "149", "(", "95.3", "%", ")", "patients", "approached", "agreed", "to", "participate", "and", "were", "randomized", ".", "Seventeen", "of", "24", "(", "70.8", "%", ")", "medical", "oncologists", "approached", "and", "randomized", "patients", ".", "The", "142", "patients", "received", "a", "total", "of", "495", "cycles", "of", "chemotherapy", ".", "Aggregate", "incidences", "of", "a", "first", "event", "by", "patient", "were", "FN", "(", "8", "/", "142", ",", "5.6", "%", ")", ",", "treatment", "-", "related", "hospitalization", "(", "6", "/", "142", ",", "4.2", "%", ")", ",", "chemotherapy", "discontinuation", "(", "7", "/", "142", ",", "4.9", "%", ")", ",", "chemotherapy", "delays", "(", "5", "/", "142", ",", "3.5", "%", ")", ",", "and", "chemotherapy", "dose", "reduction", "(", "18", "/", "142", ",", "12.7", "%", ")", ".", "Overall", ",", "31.7", "%", "(", "45", "/", "142", ")", "of", "patients", "and", "9.0", "%", "(", "45", "/", "495", ")", "of", "chemotherapy", "cycles", "were", "associated", "with", "one", "of", "these", "first", "events", ".", "This", "study", "met", "its", "feasibility", "endpoints", ".", "This", "novel", "pragmatic", "trial", "approach", "offers", "a", "means", "of", "comparing", "standard", "of", "care", "treatments", "in", "a", "practical", "and", "cost", "-", "effective", "manner", ".", "The", "trial", "will", "now", "be", "expanded", "to", "compare", "rates", "of", "FN", "between", "the", "three", "filgrastim", "schedules", ".", "ClinicalTrials.gov", ":", "NCT", "02428114", "." ]

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1003

[ "A", "phase", "II", ",", "randomized", ",", "blinded", "study", "of", "the", "farnesyltransferase", "inhibitor", "tipifarnib", "combined", "with", "letrozole", "in", "the", "treatment", "of", "advanced", "breast", "cancer", "after", "antiestrogen", "therapy", ".", "This", "study", "assessed", "the", "clinical", "efficacy", "of", "the", "farnesyltransferase", "inhibitor", ",", "tipifarnib", ",", "combined", "with", "letrozole", "in", "patients", "with", "advanced", "breast", "cancer", "and", "disease", "progression", "following", "antiestrogen", "therapy", ".", "Postmenopausal", "women", "with", "estrogen", "-", "receptor", "-", "positive", "advanced", "breast", "cancer", "that", "had", "progressed", "after", "tamoxifen", "were", "given", "2.5", "mg", "letrozole", "once", "daily", "and", "were", "randomly", "assigned", "(", "2", ":1", ")", "to", "tipifarnib", "300", "mg", "(", "TL", ")", "or", "placebo", "(", "L", ")", "twice", "daily", "for", "21", "consecutive", "days", "in", "28", "-day", "cycles", ".", "The", "primary", "endpoint", "was", "objective", "response", "rate", ".", "Of", "120", "patients", "treated", "with", "TL", "(", "n", "=", "80", ")", "or", "L", "(", "n", "=", "40", ")", ",", "113", "were", "evaluable", "for", "response", ".", "Objective", "response", "rate", "was", "30", "%", "(", "95", "%", "CI", ";", "20", "-", "41", "%", ")", "for", "TL", "and", "38", "%", "(", "95", "%", "CI", ";", "23", "-", "55", "%", ")", "for", "L", ".", "There", "was", "no", "significant", "difference", "in", "response", "duration", ",", "time", "to", "disease", "progression", "or", "survival", ".", "Clinical", "benefit", "rates", "were", "49", "%", "(", "TL", ")", "and", "62", "%", "(", "L", ")", ".", "Tipifarnib", "was", "generally", "well", "tolerated", ";", "a", "higher", "incidence", "of", "drug", "-", "related", "asymptomatic", "grade", "3", "/", "4", "neutropenia", "was", "observed", "for", "TL", "(", "18", "%", ")", "than", "for", "L", "(", "0", "%", ")", ".", "Tipifarnib", "population", "pharmacokinetics", "were", "similar", "to", "previous", "studies", ",", "with", "no", "significant", "difference", "in", "trough", "letrozole", "concentrations", "between", "the", "TL", "and", "L", "groups", ".", "Adding", "tipifarnib", "to", "letrozole", "did", "not", "improve", "objective", "response", "rate", "in", "this", "population", "of", "patients", "with", "advanced", "breast", "cancer", "." ]

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1004

[ "Comparing", "an", "olive", "oil", "-", "enriched", "diet", "to", "a", "standard", "lower", "-", "fat", "diet", "for", "weight", "loss", "in", "breast", "cancer", "survivors", ":", "a", "pilot", "study", ".", "Traditional", "diets", "that", "include", "moderate", "to", "high", "intakes", "of", "extra", "virgin", "olive", "oil", "have", "been", "related", "to", "a", "decrease", "in", "breast", "cancer", "risk", ".", "We", "hypothesized", "that", "an", "olive", "oil", "-", "enriched", "diet", "would", "lead", "to", "greater", "weight", "loss", "and", "acceptance", ",", "compared", "with", "a", "standard", "diet", ",", "in", "women", "previously", "diagnosed", "with", "invasive", "breast", "cancer", ".", "Participants", "consumed", "a", "National", "Cancer", "Institute", "(", "NCI", ")", "diet", "(", "total", "fat", ">", "15", "%", "and", "<", "30", "%", ")", "and", "a", "plant", "-", "based", "olive", "oil", "diet", "(", "PBOO", ";", ">", "or", "=", "3", "tablespoons", "of", "olive", "oil", "/", "day", ")", "for", "8", "weeks", ",", "each", "with", "random", "assignment", "to", "the", "order", ".", "We", "established", "a", "weight", "loss", "goal", "of", "at", "least", "5", "%", "of", "baseline", "weight", ".", "After", "completion", "of", "the", "two", "diet", "trials", ",", "each", "participant", "self", "-", "selected", "one", "of", "the", "diets", "for", "an", "additional", "6", "months", "of", "follow", "-", "up", "for", "weight", "management", ".", "Body", "measures", "were", "done", "before", "and", "after", "each", "diet", "and", "after", "follow", "-", "up", ";", "fasting", "blood", "samples", "were", "collected", "after", "each", "diet", "and", "after", "follow", "-", "up", ".", "Forty", "-", "four", "overweight", "women", "started", "and", "28", "completed", "the", "44", "-week", "protocol", ".", "Twelve", "(", "80", "%", ")", "of", "the", "15", "women", "who", "started", "with", "the", "PBOO", "diet", "achieved", "a", "weight", "loss", "of", ">", "or", "=", "5", "%", "compared", "to", "4", "(", "31", "%", ")", "of", "the", "13", "who", "started", "with", "the", "NCI", "diet", "(", "p", "<", "0.01", ")", ".", "Nineteen", "of", "the", "22", "women", "eligible", "for", "follow", "-", "up", "chose", "the", "PBOO", "diet", ",", "and", "all", "completed", "the", "study", ".", "Of", "the", "3", "women", "who", "chose", "the", "NCI", "diet", "for", "follow", "-", "up", ",", "1", "completed", "the", "study", ".", "The", "PBOO", "diet", "resulted", "in", "lower", "triglycerides", "(", "NCI", "105", "+", "/-", "46", "mg", "/", "dL", ",", "PBOO", "96", "+", "/-", "37", "mg", "/", "dL", ",", "p", "=", "0.06", ")", "and", "higher", "high", "-", "density", "lipoprotein", "cholesterol", "(", "HDL", "-", "C", ")", "(", "NCI", "64", "+", "/-", "13", "mg", "/", "dL", ",", "PBOO", "68", "+", "/-", "12", "mg", "/", "dL", ",", "p", "=", "0.001", ")", ".", "An", "olive", "oil", "-", "enriched", "diet", "brought", "about", "greater", "weight", "loss", "than", "a", "lower", "-", "fat", "diet", "in", "an", "8", "-week", "comparison", ".", "Moreover", ",", "these", "women", "chose", ",", "overwhelmingly", ",", "the", "olive", "oil", "-", "enriched", "diet", "for", "6", "months", "of", "follow", "-", "up", ".", "An", "olive", "oil", "-", "enriched", "diet", "may", "be", "more", "efficacious", "for", "weight", "loss", "in", "breast", "cancer", "survivors", "than", "a", "standard", "lower", "-", "fat", "diet", "." ]

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1005

[ "[", "A", "pilot", "study", "of", "weekly", "versus", "3", "-week", "docetaxel", "in", "combination", "with", "capecitabine", "in", "patients", "with", "anthracycline", "-", "pretreated", "metastatic", "breast", "cancer", "]", ".", "To", "evaluate", "the", "efficacy", "and", "safety", "of", "weekly", "or", "3", "-week", "docetaxel", "in", "combination", "with", "capecitabine", ".", "83", "Patients", "with", "at", "least", "one", "measurable", "lesion", "were", "randomized", "to", "receive", "the", "treatment", "arms", ":", "docetaxel", "37.5", "mg", "/", "m", "(", "2", ")", "on", "days", "1", "and", "8", ",", "oral", "capecitabine", "950", "mg", "/", "m", "(", "2", ")", "twice", "daily", "on", "days", "1", "-", "14", "(", "Group", "A", ")", ";", "docetaxel", "75", "mg", "/", "m", "(", "2", ")", "on", "days", "1", ",", "oral", "capecitabine", "950", "mg", "/", "m", "(", "2", ")", "twice", "daily", "on", "days", "1", "-", "14", "(", "Group", "B", ")", ".", "Each", "cycle", "was", "repeated", "every", "3", "weeks", ".", "Eighty", "-", "three", "patients", "were", "enrolled", ",", "78", "eligible", "for", "tumor", "assessment", ".", "The", "overall", "clinical", "response", "rate", "of", "all", "groups", "was", "61.4", "%", "(", "51", "/", "83", ")", ".", "There", "was", "no", "progressive", "disease", "(", "PD", ")", "after", "two", "cycles", ".", "Efficacy", "outcomes", "were", "similar", "in", "the", "two", "groups", ".", "The", "response", "rate", "of", "group", "A", "and", "B", "were", "61.8", "%", "(", "21", "/", "34", ")", "and", "61.2", "%", "(", "30", "/", "49", ")", "respectively", ".", "There", "were", "no", "drug", "-", "related", "deaths", "observed", ".", "Neutropenia", "was", "the", "most", "common", "toxicity", ".", "In", "all", ",", "the", "frequency", "of", "Grade", "3", "/", "4", "neutropenia", "were", "45.8", "%", "(", "38", "/", "83", ")", ",", "but", "Grade", "3", "/", "4", "neutropenia", "of", "Group", "B", "55.1", "%", "(", "27", "/", "49", ")", "was", "higher", "than", "Group", "A", "32.4", "%", "(", "11", "/", "34", ")", ",", "P", "=", "0.04", ".", "The", "study", "confirmed", "the", "superior", "activity", "of", "docetaxe", "-", "capecitabine", "combination", "therapy", "in", "anthracycline", "resistant", "MBC", ",", "and", "comparing", "with", "3", "-week", "schedule", ",", "weekly", "docetaxel", "plus", "capecitabine", "has", "same", "high", "efficacy", "with", "a", "favourable", "safety", "profile", "." ]

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1006

[ "Phase", "III", "randomized", "equivalence", "trial", "of", "early", "breast", "cancer", "treatments", "with", "or", "without", "axillary", "clearance", "in", "post", "-", "menopausal", "patients", "results", "after", "5", "years", "of", "follow", "-", "up", ".", "Axillary", "lymph", "node", "clearance", "(", "ALNC", ")", "improves", "locoregional", "control", "and", "provides", "prognostic", "information", "for", "early", "breast", "cancer", "treatment", ",", "but", "effects", "on", "survival", "are", "controversial", ".", "This", "multicentre", ",", "randomized", "pragmatic", "equivalence", "trial", "compares", "outcomes", "for", "post", "-", "menopausal", "early", "invasive", "breast", "cancer", "patients", "after", "locoregional", "treatment", "with", "ALNC", "and", "adjuvant", "therapies", "to", "outcomes", "after", "locoregional", "treatment", "without", "ALNC", "and", "adjuvant", "therapies", ".", "From", "1995", "-", "2005", ",", "women", "aged", "≥", "50", "years", "with", "early", "breast", "cancer", "(", "tumor", "≤", "10", "mm", ")", "and", "clinically", "-", "negative", "axillary", "nodes", "were", "randomized", "to", "receive", "treatment", "with", "ALNC", "(", "Ax", ")", "or", "without", "(", "no", "-", "Ax", ")", ".", "Adjuvant", "therapies", "were", "prescribed", "according", "to", "hormonal", "receptor", "status", "and", "individual", "histological", "results", ".", "The", "primary", "endpoint", "was", "overall", "survival", "(", "OS", ")", ";", "secondary", "endpoints", "were", "event", "-", "free", "survival", "(", "EFS", ")", "and", "functional", "outcomes", ".", "The", "trial", "was", "terminated", "due", "to", "lack", "of", "equivalence", "and", "low", "accrual", "after", "first", "interim", "analyses", ".", "NCT", "00210236", ".", "Of", "625", "patients", ",", "297", "no", "-", "Ax", "and", "310", "Ax", "patients", "were", "maintained", "for", "final", "per", "-", "protocol", "analyses", ".", "OS", "and", "EFS", "at", "five", "years", "were", "not", "equivalent", "(", "Ax", "vs.", "no", "-", "Ax", ":", "98", "%", "vs.", "94", "%", "and", "96", "%", "vs.", "90", "%", "respectively", ")", ".", "Recurrence", "was", "higher", "for", "no", "-", "Ax", ",", "particularly", "in", "the", "first", "five", "years", "after", "surgery", ".", "Axillary", "nodes", "were", "positive", "for", "14", "%", "Ax", "patients", "but", "only", "2", "%", "no", "-", "Ax", "patients", "experienced", "axillary", "node", "recurrence", ".", "Functional", "impairments", "were", "greater", "after", "ALNC", ".", "Our", "results", "fail", "to", "demonstrate", "equivalence", "of", "outcomes", "when", "ALNC", "is", "omitted", "from", "post", "-", "menopausal", "early", "breast", "cancer", "patient", "treatment", ".", "However", "the", "low", "locoregional", "recurrence", "rates", "warrant", "further", "examination", "over", "a", "longer", "duration", ",", "in", "particular", "to", "consider", "whether", "these", "would", "impact", "on", "survival", "." ]

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1007

[ "Pectoral", "nerve", "blocks", "to", "improve", "analgesia", "after", "breast", "cancer", "surgery", ":", "A", "prospective", ",", "randomized", "and", "controlled", "trial", ".", "To", "evaluate", "the", "analgesic", "efficacy", "of", "ultrasound", "guided", "combined", "pectoral", "nerve", "blocks", "I", "and", "II", "in", "patients", "scheduled", "for", "surgery", "for", "breast", "cancer", ".", "Prospective", ",", "randomized", ",", "control", "trial", ".", "Operating", "rooms", "in", "a", "tertiary", "care", "hospital", "of", "Northern", "India", ".", "Sixty", "American", "Society", "of", "Anesthesiologists", "status", "I", "to", "II", "adult", "women", ",", "aged", "18", "-", "70", "years", "were", "enrolled", "in", "this", "study", ".", "Patients", "were", "randomized", "into", "two", "groups", "(", "30", "patients", "in", "each", "group", ")", ",", "PECS", "(", "P", ")", "group", "and", "control", "(", "C", ")", "group", ".", "In", "group", "P", ",", "patients", "received", "both", "general", "anesthesia", "and", "ultrasound", "guided", "combined", "pectoral", "nerve", "blocks", "(", "PECS", "I", "and", "II", ")", ".", "In", "group", "C", ",", "patients", "received", "only", "general", "anesthesia", ".", "We", "noted", "pain", "intensity", "at", "rest", "and", "during", "abduction", "of", "the", "ipsilateral", "upper", "limb", ",", "incidence", "of", "postoperative", "nausea", "and", "vomiting", ";", "patient", "'s", "satisfaction", "with", "postoperative", "analgesia", "and", "maximal", "painless", "abduction", "at", "different", "time", "intervals", "in", "both", "groups", ".", "There", "was", "significant", "decrease", "in", "the", "total", "amount", "of", "fentanyl", "requirement", "in", "the", "in", "P", "group", "{", "(", "140.66", "±", "31.80", "μg", ")", "and", "(", "438", "±", "71.74", "μg", ")", "}", "in", "comparison", "to", "C", "group", "{", "(", "218.33", "±", "23.93", "μg", ")", "and", "(", "609", "±", "53.00", "μg", ")", "}", "during", "intraoperative", "and", "post", "-", "operative", "period", "upto", "24", "h", "respectively", ".", "The", "time", "to", "first", "analgesic", "requirement", "was", "also", "more", "in", "P", "group", "(", "44.33", "±", "17.65", "min", ")", "in", "comparison", "to", "C", "group", "(", "10.36", "±", "4.97", "min", ")", "during", "post", "-", "operative", "period", ".", "There", "was", "less", "limitation", "of", "shoulder", "movement", "(", "pain", "free", "mobilization", ")", "on", "the", "operative", "site", "at", "4", "h", "and", "5", "h", "after", "surgery", "in", "P", "group", "in", "comparison", "to", "C", "group", ".", "However", "there", "was", "no", "difference", "in", "the", "incidence", "of", "post", "-", "operative", "nausea", "and", "vomiting", "(", "22", "out", "of", "30", "patients", "in", "group", "P", "and", "20", "out", "of", "30", "patients", "in", "group", "C", ")", "but", "patients", "in", "group", "P", "had", "a", "better", "satisfaction", "score", "with", "postoperative", "analgesia", "than", "C", "group", "having", "a", "p", "value", "of", "<", "0.001", "(", "Score", "1", ";", "5", "VS", "20", ";", "Score", "2", ";", "12", "VS", "9", ";", "Score", "3", ";", "13", "VS", "1", ")", ".", "Ultrasound", "guided", "combined", "pectoral", "nerve", "blocks", "are", "an", "effective", "modality", "of", "analgesia", "for", "patients", "undergoing", "breast", "surgeries", "during", "perioperative", "period", ".", "CTRI", "/", "2015", "/", "12", "/", "006457", "." ]

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1008

[ "Sentinel", "node", "biopsy", "in", "breast", "cancer", ":", "validation", "study", "and", "comparison", "of", "blue", "dye", "alone", "with", "triple", "modality", "localization", ".", "Sentinel", "node", "biopsy", "(", "SNB", ")", "for", "breast", "cancer", "patients", "is", "a", "new", "technique", "with", "the", "potential", "to", "provide", "an", "accurate", "staging", "of", "the", "axillary", "nodal", "status", "while", "avoiding", "the", "morbidity", "of", "an", "axillary", "dissection", ".", "The", "objective", "of", "the", "present", "study", "is", "to", "validate", "the", "use", "of", "sentinel", "node", "biopsy", "in", "a", "New", "Zealand", "hospital", "and", "to", "compare", "the", "ability", "of", "patent", "blue", "dye", "(", "PB", ")", "alone", "with", "triple", "modality", "(", "TM", ")", "(", "preoperative", "lymphoscintigraphy", ",", "intraoperative", "gamma", "probe", "and", "intraoperative", "blue", "dye", ")", "to", "identify", "the", "sentinel", "node", ".", "A", "total", "of", "104", "patients", "who", "had", "a", "palpable", "breast", "lump", "that", "was", "confirmed", "to", "be", "malignant", "by", "radiology", "and", "cytology", "and", "a", "clinical", "diagnosis", "of", "stage", "I", "or", "stage", "II", "breast", "cancer", ",", "were", "enrolled", "for", "SNB", "and", "randomly", "assigned", "to", "triple", "modality", "or", "blue", "dye", "alone", "for", "the", "localization", "of", "the", "sentinel", "node", ".", "Axillary", "dissection", "was", "performed", "after", "the", "sentinel", "node", "(", "s", ")", "had", "been", "removed", ".", "There", "were", "63", "patients", "in", "the", "PB", "group", "and", "41", "patients", "in", "the", "TM", "group", ".", "Both", "groups", "are", "comparable", ",", "with", "a", "similar", "mean", "age", "and", "primary", "tumour", "size", ".", "A", "sentinel", "node", "was", "identified", "in", "57", "(", "90", "%", ")", "of", "the", "PB", "group", "patients", "and", "40", "(", "98", "%", ")", "of", "the", "TM", "group", "patients", ".", "Of", "these", "23", "(", "37", "%", ")", "of", "the", "PB", "group", "and", "23", "(", "56", "%", ")", "in", "the", "TM", "group", "had", "axillary", "nodes", "positive", "for", "malignancy", ".", "There", "was", "one", "false", "negative", "SNB", "in", "the", "PB", "group", "and", "two", "false", "negative", "results", "in", "the", "TM", "group", ".", "Therefore", ",", "the", "PB", "group", "had", "an", "accuracy", "of", "98", "%", "and", "a", "sensitivity", "of", "96", "%", "compared", "to", "an", "accuracy", "of", "95", "%", "and", "a", "sensitivity", "of", "91", "%", "for", "the", "TM", "group", ".", "The", "results", "of", "the", "present", "study", "validate", "the", "use", "of", "SNB", "in", "suitable", "breast", "cancer", "patients", ".", "Identification", "and", "the", "accuracy", "of", "the", "sentinel", "node", "localization", "were", "similar", "between", "the", "two", "groups", ".", "Therefore", ",", "in", "hospital", "centres", "without", "adequate", "access", "to", "a", "nuclear", "medical", "facility", ",", "it", "would", "be", "feasible", "to", "conduct", "SNB", "using", "blue", "dye", "alone", "." ]

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1009

[ "Epirubicin", "-", "based", "chemotherapy", "as", "adjuvant", "treatment", "for", "poor", "prognosis", ",", "node", "-", "negative", "breast", "cancer", ":", "10", "-year", "follow", "-", "up", "results", "of", "the", "French", "Adjuvant", "Study", "Group", "03", "trial", ".", "We", "evaluated", "the", "contribution", "of", "an", "epirubicin", "-", "based", "adjuvant", "chemotherapy", "on", "disease", "-", "free", "survival", "(", "DFS", ")", "in", "poor", "prognosis", ",", "node", "-", "negative", "breast", "cancer", "(", "BC", ")", "patients", ".", "Poor", "prognostic", "factors", "were", "defined", "as", ":", "pathologic", "tumor", "size", ">", "or=", "4", "cm", ",", "estrogen", "-", "receptor", "negative", ",", "and", "progesterone", "-", "receptor", "negative", ".", "Scarff", "-", "Bloom", "Richardson", "grade", "2", "tumors", "must", "have", "two", "of", "these", "factors", ",", "and", "only", "one", "in", "case", "of", "grade", "3", ".", "Between", "1988", "and", "1994", ",", "328", "patients", "were", "randomized", "to", "receive", "either", "no", "systemic", "treatment", "(", "control", ",", "n", "=", "161", ")", ",", "or", "fluorouracil", "500", "mg", "/", "m", "(", "2", ")", ",", "epirubicin", "50", "mg", "/", "m", "(", "2", ")", ",", "cyclophosphamide", "500", "mg", "/", "m", "(", "2", ")", ",", "6", "cycles", "every", "21", "days", "(", "FEC", "50", ",", "n", "=", "167", ")", ",", "without", "any", "hormonal", "treatment", ".", "The", "median", "follow", "up", "was", "114", "months", ".", "The", "10", "-year", "DFS", "rates", "were", "64", "and", "71", "%", ",", "respectively", "(", "p", "=", "0.23", ")", ".", "In", "the", "Cox", "regression", "model", ",", "independent", "prognostic", "factors", "of", "relapse", "were", "the", "number", "of", "nodes", "examined", "<", "10", "(", "p", "=", "0.002", ")", ",", "BCS", "(", "p", "=", "0.01", ")", ",", "and", "premenopausal", "status", "(", "p", "=", "0.04", ")", ".", "In", "this", "model", ",", "the", "relative", "risk", "of", "relapse", "was", "1.46", "(", "CI", "95", "%", ":", "1.05", "-", "1.87", ")", "in", "favor", "of", "FEC", "50", ".", "In", "patients", "who", "underwent", "BCS", ",", "21", "%", "developed", "a", "local", "relapse", "(", "24", "versus", "18", "%", ",", "respectively", ")", ".", "The", "10", "-year", "local", "DFS", "was", "70.5", "and", "79.3", "%", ",", "respectively", "(", "p", "=", "0.27", ")", ".", "The", "10", "-year", "overall", "survival", "was", "not", "different", "(", "74.1", "versus", "70.7", "%", ",", "p", "=", "0.82", ")", ".", "After", "10", "years", "of", "follow", "-", "up", ",", "the", "FEC", "50", "regimen", "reduced", "the", "risk", "of", "relapse", "in", "poor", "-", "prognosis", "node", "-", "negative", "BC", "patients", ".", "The", "incidence", "of", "local", "relapse", "was", "high", ",", "and", "probably", "related", "to", "inclusion", "criteria", ".", "Epirubicin", "was", "probably", "underdosed", "in", "such", "patients", ",", "and", "ongoing", "studies", "using", "100", "mg", "/", "m", "(", "2", ")", "of", "epirubicin", "will", "give", "us", "the", "answer", "in", "a", "near", "future", "." ]

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1010

[ "Better", "pathologic", "complete", "response", "and", "relapse", "-", "free", "survival", "after", "carboplatin", "plus", "paclitaxel", "compared", "with", "epirubicin", "plus", "paclitaxel", "as", "neoadjuvant", "chemotherapy", "for", "locally", "advanced", "triple", "-", "negative", "breast", "cancer", ":", "a", "randomized", "phase", "2", "trial", ".", "No", "standard", "chemotherapy", "is", "used", "as", "neoadjuvant", "therapy", "in", "triple", "negative", "breast", "cancer", "(", "TNBC", ")", ".", "This", "study", "has", "compared", "carboplatin", "plus", "paclitaxel", "with", "commonly", "used", "epirubicin", "plus", "paclitaxel", "as", "neoadjuvant", "chemotherapy", "(", "NAC", ")", "in", "TNBC", ".", "91", "patients", "with", "a", "median", "age", "of", "47", "years", "(", "PC", "47", "patients", ",", "EP", "44", "patients", ")", "were", "enrolled", ".", "65", "%", "of", "the", "patients", "were", "premenopausal", ".", "While", "the", "objective", "response", "rate", "was", "similar", "in", "the", "PC", "and", "EP", "arm", "(", "89.4", "%", "vs.", "79.5", "%", ",", "P", "=", "0.195", ")", ",", "the", "pCR", "rate", "in", "the", "PC", "arm", "was", "significantly", "higher", "(", "38.6", "%", "vs.", "14.0", "%", ",", "P", "=", "0.014", ")", ".", "The", "median", "follow", "-", "up", "time", "was", "55.0", "months", ".", "5", "-year", "RFS", "were", "77.6", "%", "and", "56.2", "%", ",", "significantly", "higher", "in", "the", "PC", "arm", ",", "P", "=", "0.043", ".", "No", "significant", "difference", "in", "OS", "was", "observed", "between", "the", "two", "arms", "(", "P", "=", "0.350", ")", ".", "Adverse", "events", "were", "similar", ",", "except", "for", "more", "thrombocytopenia", "in", "the", "PC", "arm", "(", "P", "=", "0.001", ")", ".", "Patients", "with", "stage", "II", "/", "III", "TNBC", "were", "randomized", "to", "receive", "either", "paclitaxel", "(", "175", "mg", "/", "m", "2", ",", "day", "1", ")", "plus", "carboplatin", "(", "Area", "Under", "the", "Curve", "=", "5", ",", "day", "2", ")", "(", "PC", ")", "or", "epirubicin", "(", "75", "mg", "/", "m", "2", ",", "day", "1", ")", "plus", "paclitaxel", "(", "175", "mg", "/", "m", "2", ",", "day", "2", ")", "(", "EP", ")", "as", "NAC", "every", "three", "weeks", "for", "4", "-", "6", "cycles", ".", "The", "primary", "endpoint", "was", "rate", "of", "pathologic", "complete", "response", "(", "pCR", ")", ".", "The", "secondary", "endpoints", "included", "relapse", "-", "free", "survival", "(", "RFS", ")", ",", "overall", "survival", "(", "OS", ")", "and", "safety", ".", "This", "study", "suggested", "that", "the", "addition", "of", "carboplatin", "to", "paclitaxel", "was", "superior", "to", "the", "regimen", "of", "epirubicin", "plus", "paclitaxel", "as", "NAC", "for", "TNBC", "in", "terms", "of", "improving", "pCR", "rate", "and", "RFS", ".", "Further", "phase", "3", "study", "has", "already", "started", "." ]

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