Datasets:

Stardrums

/

pico-breast-cancer

like 2

[ "Bisphosphonate", "risedronate", "prevents", "bone", "loss", "in", "women", "with", "artificial", "menopause", "due", "to", "chemotherapy", "of", "breast", "cancer", ":", "a", "double", "-", "blind", ",", "placebo", "-", "controlled", "study", ".", "To", "determine", "the", "effectiveness", "and", "safety", "of", "the", "bisphosphonate", "risedronate", "in", "preventing", "bone", "loss", "in", "young", "women", "with", "breast", "cancer", "and", "early", "menopause", "induced", "by", "chemotherapy", "who", "are", "at", "major", "risk", "for", "the", "development", "of", "postmenopausal", "osteoporosis", ".", "Fifty", "-", "three", "white", "women", ",", "aged", "36", "to", "55", "years", ",", "with", "breast", "cancer", "and", "artificially", "induced", "menopause", "were", "stratified", "according", "to", "prior", "tamoxifen", "use", ".", "Thirty", "-", "six", "patients", "received", "tamoxifen", "(", "20", "mg", "/", "d", ")", ".", "Within", "each", "stratum", ",", "patients", "were", "randomly", "assigned", "to", "receive", "risedronate", "(", "n", "=", "27", ")", "or", "placebo", "(", "n", "=", "26", ")", ".", "Treatment", "consisted", "of", "eight", "cycles", "oral", "risedronate", "30", "mg", "/", "d", "or", "placebo", "daily", "for", "2", "weeks", "followed", "by", "10", "weeks", "of", "no", "drug", "(", "12", "weeks", "per", "cycle", ")", ".", "Patients", "were", "monitored", "for", "a", "third", "year", "without", "treatment", ".", "Main", "outcomes", "of", "the", "study", "were", "changes", "in", "lumbar", "spine", "and", "proximal", "femur", "(", "femoral", "neck", ",", "trochanter", ",", "and", "Ward", "'s", "triangle", ")", "bone", "mineral", "density", "(", "BMD", ")", ",", "and", "biochemical", "markers", "of", "bone", "turnover", ".", "In", "contrast", "to", "a", "significant", "decrease", "of", "BMD", "at", "the", "lumbar", "spine", "and", "hip", "in", "the", "placebo", "group", ",", "there", "was", "an", "increase", "in", "BMD", "in", "the", "risedronate", "group", ".", "On", "treatment", "withdrawal", ",", "bone", "loss", "ensued", ",", "which", "suggests", "that", "treatment", "needs", "to", "be", "continuous", "to", "maintain", "a", "protective", "effect", "on", "bone", "mass", ".", "At", "2", "years", ",", "the", "mean", "difference", "(", "+", "/-", "SEM", ")", "between", "groups", "was", "2.5", "%", "+", "/-", "1.2", "%", ",", "(", "95", "%", "confidence", "interval", "[", "CI", "]", ",", "0.2", "to", "4.9", ")", "at", "the", "lumbar", "spine", "(", "P", "=", ".", "041", ")", "and", "2.6", "%", "+", "/-", "1.1", "%", ",", "(", "95", "%", "CI", ",", "0.3", "to", "4.8", ")", "at", "the", "femoral", "neck", "(", "P", "=", ".", "029", ")", ".", "Similar", "results", "were", "observed", "at", "the", "hip", "trochanter", ".", "Results", "by", "stratum", "indicate", "a", "beneficial", ",", "although", "partial", ",", "effect", "of", "tamoxifen", "in", "reducing", "bone", "loss", ".", "Risedronate", "was", "well", "tolerated", "and", "showed", "a", "good", "safety", "profile", ",", "with", "no", "evidence", "of", "laboratory", "abnormalities", ".", "Risedronate", "appears", "to", "be", "a", "safe", "treatment", "that", "prevents", "both", "trabecular", "and", "cortical", "bone", "loss", "in", "women", "with", "menopause", "induced", "by", "chemotherapy", "for", "breast", "cancer", "." ]

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[ "Effect", "of", "penehyclidine", "hydrochloride", "on", "the", "incidence", "of", "intra", "-", "operative", "awareness", "in", "Chinese", "patients", "undergoing", "breast", "cancer", "surgery", "during", "general", "anaesthesia", ".", "Intra", "-", "operative", "awareness", "can", "lead", "to", "serious", "adverse", "psychological", "consequences", ".", "We", "conducted", "a", "prospective", ",", "randomised", ",", "double", "-", "blinded", "trial", "in", "920", "patients", "undergoing", "breast", "cancer", "surgery", "under", "bispectral", "index", "-", "guided", "total", "intravenous", "anaesthesia", "to", "evaluate", "the", "effect", "of", "penehyclidine", "hydrochloride", "on", "intra", "-", "operative", "awareness", ".", "Patients", "were", "randomly", "divided", "to", "receive", "0.01", "mg.kg", "(", "-", "1", ")", "penehyclidine", "hydrochloride", "or", "saline", "intravenously", "30", "min", "before", "surgery", ".", "The", "pre", "-", "administration", ",", "pre", "-", "operative", "anxiety", "levels", "were", "assessed", "using", "a", "100", "-mm", "visual", "analogue", "scale", ".", "Intra", "-", "operative", "awareness", "was", "defined", "as", "recall", "of", "intra", "-", "operative", "events", "using", "a", "modified", "Brice", "interview", "administered", "2", "-", "6", "h", "postoperatively", ",", "and", "in", "the", "next", "24", "-", "48", "h.", "A", "committee", "of", "three", "experts", ",", "blinded", "to", "the", "study", "conditions", ",", "independently", "scrutinised", "all", "reported", "recollections", ".", "We", "found", "no", "differences", "in", "depth", "of", "anaesthesia", "and", "patients", "'", "pre", "-", "operative", "anxiety", "levels", "between", "the", "two", "groups", ".", "The", "incidence", "of", "awareness", "with", "penehyclidine", "hydrochloride", "(", "0", "/", "456", "patients", ";", "0", "%", ")", "was", "significantly", "lower", "than", "with", "saline", "(", "5", "/", "452", ";", "1.1", "%", ")", ",", "p", "=", "0.030", ".", "We", "conclude", "that", "penehyclidine", "hydrochloride", "reduced", "the", "incidence", "of", "intra", "-", "operative", "awareness", "in", "patients", "undergoing", "breast", "cancer", "surgery", "during", "general", "anaesthesia", "." ]

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[ "Comparison", "of", "the", "sentinel", "node", "procedure", "between", "patients", "with", "multifocal", "and", "unifocal", "breast", "cancer", "in", "the", "EORTC", "10981", "-", "22023", "AMAROS", "Trial", ":", "identification", "rate", "and", "nodal", "outcome", ".", "Multifocal", "breast", "cancer", "is", "associated", "with", "a", "higher", "risk", "of", "nodal", "involvement", "compared", "to", "unifocal", "breast", "cancer", "and", "the", "drainage", "pattern", "from", "multifocal", "localisations", "may", "be", "different", ".", "For", "this", "reason", ",", "the", "value", "of", "the", "sentinel", "node", "biopsy", "(", "SNB", ")", "procedure", "for", "this", "indication", "is", "debated", ".", "The", "aim", "of", "the", "current", "analysis", "was", "to", "evaluate", "the", "sentinel", "node", "identification", "rate", "and", "nodal", "involvement", "in", "patients", "with", "a", "multifocal", "tumour", "in", "the", "EORTC", "10981", "-", "22023", "AMAROS", "trial", ".", "From", "the", "first", "4000", "registered", "patients", ",", "342", "were", "identified", "with", "a", "multifocal", "tumour", "on", "histological", "examination", "and", "compared", "to", "a", "randomly", "selected", "control", "group", "of", "684", "patients", "with", "a", "unifocal", "tumour", ".", "The", "outcome", "of", "the", "SNB", "was", "assessed", ".", "The", "sentinel", "node", "was", "identified", "in", "96", "%", "of", "the", "patients", "with", "a", "multifocal", "tumour", "and", "in", "98", "%", "of", "those", "with", "unifocal", "disease", ".", "In", "the", "multifocal", "group", ",", "51", "%", "had", "a", "metastasis", "in", "the", "sentinel", "node", "compared", "to", "28", "%", "in", "the", "unifocal", "group", ";", "and", "further", "nodal", "involvement", "after", "a", "positive", "sentinel", "node", "was", "found", "in", "40", "%", "(", "38", "/", "95", ")", "and", "39", "%", "(", "39", "/", "101", ")", "respectively", ".", "In", "this", "prospective", "international", "multicentre", "study", ",", "the", "96", "%", "detection", "rate", "indicates", "that", "the", "SNB", "procedure", "can", "be", "highly", "effective", "in", "patients", "with", "a", "multifocal", "tumour", ".", "Though", "the", "tumour", "-", "positive", "rate", "of", "the", "sentinel", "node", "was", "twice", "as", "high", "in", "the", "multifocal", "group", "compared", "to", "the", "unifocal", "group", ",", "further", "nodal", "involvement", "after", "a", "positive", "sentinel", "node", "was", "similar", "in", "both", "groups", ".", "This", "suggests", "that", "the", "SNB", "procedure", "is", "safe", "in", "patients", "with", "multifocal", "breast", "cancer", "." ]

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