Datasets:

Stardrums

/

pico-breast-cancer

like 2

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[ "Randomized", ",", "self", "-", "controlled", ",", "prospective", "assessment", "of", "the", "efficacy", "of", "mometasone", "furoate", "local", "application", "in", "reducing", "acute", "radiation", "dermatitis", "in", "patients", "with", "head", "and", "neck", "squamous", "cell", "carcinomas", ".", "Acute", "radiation", "dermatitis", "(", "ARD", ")", "is", "a", "common", "adverse", "effect", "in", "patients", "undergoing", "radiotherapy", ".", "Mometasone", "furoate", "cream", "(", "MMF", ")", "was", "reported", "to", "significantly", "reduce", "ARD", ",", "especially", "in", "breast", "cancer", ".", "Clinically", ",", "ARD", "is", "more", "critical", "and", "more", "difficult", "to", "prevent", "in", "patients", "with", "head", "and", "neck", "squamous", "cell", "carcinoma", "(", "HNSCC", ")", "than", "in", "those", "with", "breast", "cancer", ",", "because", "a", "higher", "dose", "of", "radiotherapy", "is", "required", "in", "HNSCC", "cases", ".", "The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "effect", "of", "MMF", "local", "application", "on", "radiation", "dermatitis", "in", "patients", "with", "HNSCC", ".", "HNSCC", "patients", "scheduled", "for", "bilateral", "radical", "radiotherapy", "to", "the", "neck", "with", "identical", "radiation", "doses", "were", "enrolled", ".", "One", "side", "of", "the", "neck", "skin", "(", "test", "groups", ")", "of", "the", "patients", "were", "randomized", "to", "apply", "a", "thin", "layer", "of", "MMF", "once", "a", "day", "from", "the", "date", "of", "first", "radiotherapy", "until", "either", "2", "weeks", "after", "end", "of", "radiotherapy", "or", "until", "the", "test", "side", "skin", "developed", "ARD", "lesions", ",", "while", "the", "other", "side", "of", "neck", "(", "control", "groups", ")", "did", "n't", "apply", "any", "medication", ".", "The", "severity", "of", "ARD", "was", "evaluated", "weekly", "by", "using", "the", "modified", "radiation", "therapy", "oncology", "group", "score", ",", "pain", "intensity", ",", "and", "itch", "stages", ".", "Forty", "-", "one", "patients", "(", "82", "targets", ")", "were", "analyzed", ".", "There", "was", "a", "significant", "difference", "between", "the", "ARD", "scores", "on", "the", "test", "side", "and", "the", "control", "side", ".", "MMF", "reduced", "the", "stages", "of", "ARD", "when", "the", "radiotherapy", "dose", "was", "<", "6000", "cGY", "(", "P", "=", ".", "01", ")", "but", "showed", "no", "improvement", "when", "the", "dose", "was", "≥", "6000", "cGY", "(", "P", "=", ".", "699", ")", ".", "Compared", "to", "the", "control", "side", ",", "local", "application", "of", "MMF", "significantly", "reduced", "the", "itch", "and", "pain", "scores", "of", "the", "test", "side", "skin", "regardless", "of", "the", "radiotherapy", "dose", "and", "ARD", "stage", "(", "P", "<", ".", "001", ")", "during", "radiotherapy", ".", "This", "study", "showed", "that", "MMF", "inunction", "after", "high", "-", "dose", "radiotherapy", "(", ">", "50", "Gy", ")", "can", "prevent", "ARD", ",", "especially", "when", "the", "radiation", "dose", "is", "<", "6000", "cGY", "." ]

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