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METHODS | Each treatment group received both an injection and a tablet to reduce treatment group variability . | Each treatment group received both an injection and a tablet to reduce treatment group variability. |
METHODS | Patients were evaluated using the Brief Psychiatric Rating Scale ( BPRS ) and the Positive and Negative Syndrome Scale ( PANSS ) before receiving medication and at 30 and 90 minutes after medication was administered . | Patients were evaluated using the Brief Psychiatric Rating Scale (BPRS) and the Positive and Negative Syndrome Scale (PANSS) before receiving medication and at 30 and 90 minutes after medication was administered. |
METHODS | The intergroup mean percent reductions in rating scale scores were compared using ANOVA , chi-square , and Kruskal-Wallis tests . | The intergroup mean percent reductions in rating scale scores were compared using ANOVA, chi-square, and Kruskal-Wallis tests. |
RESULTS | There were no statistically significant differences among the groups at any point . | There were no statistically significant differences among the groups at any point. |
RESULTS | The two groups receiving an antipsychotic plus lorazepam showed a trend towards increased symptom reduction compared with the group receiving lorazepam alone , although this trend was not statistically significant . | The two groups receiving an antipsychotic plus lorazepam showed a trend towards increased symptom reduction compared with the group receiving lorazepam alone, although this trend was not statistically significant. |
CONCLUSIONS | Lorazepam alone was as effective as lorazepam plus haloperidol or lorazepam plus risperidone in this small trial . | Lorazepam alone was as effective as lorazepam plus haloperidol or lorazepam plus risperidone in this small trial. |
CONCLUSIONS | While not statistically significant , a trend toward better outcomes with combined treatment warrants further study . | While not statistically significant, a trend toward better outcomes with combined treatment warrants further study. |
OBJECTIVE | To prospectively evaluate the efficacy of routine ultrasound-guided fine-needle aspiration cytology ( FNAC ) of thyroid nodules in an endemic area and to analyze the factors influencing it . | To prospectively evaluate the efficacy of routine ultrasound-guided fine-needle aspiration cytology (FNAC) of thyroid nodules in an endemic area and to analyze the factors influencing it. |
METHODS | Patients with thyroid nodules were randomly subjected to either conventional palpation-guided fine-needle aspiration cytology ( PFNAC ) or ultrasound-guided fine-needle aspiration cytology ( USFNAC ) . | Patients with thyroid nodules were randomly subjected to either conventional palpation-guided fine-needle aspiration cytology (PFNAC) or ultrasound-guided fine-needle aspiration cytology (USFNAC). |
METHODS | The results of cytology were compared with the final histopathologic diagnosis in 112 patients who had undergone surgery . | The results of cytology were compared with the final histopathologic diagnosis in 112 patients who had undergone surgery. |
METHODS | The performance of both methods was individually analyzed in solid nodules , cystic nodules , and solitary and multinodular goitres . | The performance of both methods was individually analyzed in solid nodules, cystic nodules, and solitary and multinodular goitres. |
RESULTS | Overall , USFNAC showed a significantly higher sensitivity ( 83.3 % vs 54.6 % , p < .001 ) , positive predictive value ( 100 % vs 85.7 % , p < .001 ) , and greater diagnostic accuracy ( 96.5 % vs 89.1 % , p = .052 ) compared with PFNAC . | Overall, USFNAC showed a significantly higher sensitivity (83. 3 % vs 54. 6 %, p <. 001), positive predictive value (100 % vs 85. 7 %, p <. 001), and greater diagnostic accuracy (96. 5 % vs 89. 1 %, p =. 052) compared with PFNAC. |
RESULTS | The sensitivity of USFNAC was significantly higher compared with that of PFNAC in cystic and complex nodules ( 75 % vs 50 % , p < .001 ) but not in solid nodules ( 77.8 % vs 75 % , p > .05 ) . | The sensitivity of USFNAC was significantly higher compared with that of PFNAC in cystic and complex nodules (75 % vs 50 %, p <. 001) but not in solid nodules (77. 8 % vs 75 %, p >. 05). |
RESULTS | USFNAC was more sensitive and more accurate than PFNAC for detection of malignancy in multinodular goitres ( 66.7 % vs 50 % , p < .05 ; 95.6 % vs 86.2 % , p < .05 , respectively ) . | USFNAC was more sensitive and more accurate than PFNAC for detection of malignancy in multinodular goitres (66. 7 % vs 50 %, p <. 05 ; 95. 6 % vs 86. 2 %, p <. 05, respectively). |
CONCLUSIONS | The superiority of `` routine '' USFNAC over PFNAC is mainly due to its better performance in cystic nodules and multinodular goitres . | The superiority of '' routine '' USFNAC over PFNAC is mainly due to its better performance in cystic nodules and multinodular goitres. |
CONCLUSIONS | Hence , routine USFNAC can be recommended in areas where such lesions constitute the majority of thyroid nodules . | Hence, routine USFNAC can be recommended in areas where such lesions constitute the majority of thyroid nodules. |
BACKGROUND | Dalcetrapib modulates cholesteryl ester transfer protein ( CETP ) activity to raise high-density lipoprotein cholesterol ( HDL-C ) . | Dalcetrapib modulates cholesteryl ester transfer protein (CETP) activity to raise high-density lipoprotein cholesterol (HDL-C). |
BACKGROUND | After the failure of torcetrapib it was unknown if HDL produced by interaction with CETP had pro-atherogenic or pro-inflammatory properties . | After the failure of torcetrapib it was unknown if HDL produced by interaction with CETP had pro-atherogenic or pro-inflammatory properties. |
BACKGROUND | dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints . | dal-PLAQUE is the first multicentre study using novel non-invasive multimodality imaging to assess structural and inflammatory indices of atherosclerosis as primary endpoints. |
METHODS | In this phase 2b , double-blind , multicentre trial , patients ( aged 18-75 years ) with , or with high risk of , coronary heart disease were randomly assigned ( 1:1 ) to dalcetrapib 600 mg/day or placebo for 24 months . | In this phase 2b, double-blind, multicentre trial, patients (aged 18-75 years) with, or with high risk of, coronary heart disease were randomly assigned (1:1) to dalcetrapib 600 mg/day or placebo for 24 months. |
METHODS | Randomisation was done with a computer-generated randomisation code and was stratified by centre . | Randomisation was done with a computer-generated randomisation code and was stratified by centre. |
METHODS | Patients and investigators were masked to treatment . | Patients and investigators were masked to treatment. |
METHODS | Coprimary endpoints were MRI-assessed indices ( total vessel area , wall area , wall thickness , and normalised wall index [ average carotid ] ) after 24 months and ( 18 ) F-fluorodeoxyglucose ( ( 18 ) F-FDG ) PET/CT assessment of arterial inflammation within an index vessel ( right carotid , left carotid , or ascending thoracic aorta ) after 6 months , with no-harm boundaries established before unblinding of the trial . | Coprimary endpoints were MRI-assessed indices (total vessel area, wall area, wall thickness, and normalised wall index [average carotid]) after 24 months and (18) F-fluorodeoxyglucose ((18) F-FDG) PET/CT assessment of arterial inflammation within an index vessel (right carotid, left carotid, or ascending thoracic aorta) after 6 months, with no-harm boundaries established before unblinding of the trial. |
METHODS | Analysis was by intention to treat . | Analysis was by intention to treat. |
METHODS | This trial is registered at ClinicalTrials.gov , NCT00655473 . | This trial is registered at ClinicalTrials. gov, NCT00655473. |
RESULTS | 189 patients were screened and 130 randomly assigned to placebo ( 66 patients ) or dalcetrapib ( 64 patients ) . | 189 patients were screened and 130 randomly assigned to placebo (66 patients) or dalcetrapib (64 patients). |
RESULTS | For the coprimary MRI and PET/CT endpoints , CIs were below the no-harm boundary or the adverse change was numerically lower in the dalcetrapib group than in the placebo group . | For the coprimary MRI and PET/CT endpoints, CIs were below the no-harm boundary or the adverse change was numerically lower in the dalcetrapib group than in the placebo group. |
RESULTS | MRI-derived change in total vessel area was reduced in patients given dalcetrapib compared with those given placebo after 24 months ; absolute change from baseline relative to placebo was -401 mm ( 2 ) ( 90 % CI -723 to -080 ; nominal p = 004 ) . | MRI-derived change in total vessel area was reduced in patients given dalcetrapib compared with those given placebo after 24 months ; absolute change from baseline relative to placebo was -401 mm (2) (90 % CI -723 to -080 ; nominal p = 004). |
RESULTS | The PET/CT measure of index vessel most-diseased-segment target-to-background ratio ( TBR ) was not different between groups , but carotid artery analysis showed a 7 % reduction in most-diseased-segment TBR in the dalcetrapib group compared with the placebo group ( -73 [ 90 % CI -135 to -08 ] ; nominal p = 007 ) . | The PET/CT measure of index vessel most-diseased-segment target-to-background ratio (TBR) was not different between groups, but carotid artery analysis showed a 7 % reduction in most-diseased-segment TBR in the dalcetrapib group compared with the placebo group (-73 [90 % CI -135 to -08] ; nominal p = 007). |
RESULTS | Dalcetrapib did not increase office blood pressure and the frequency of adverse events was similar between groups . | Dalcetrapib did not increase office blood pressure and the frequency of adverse events was similar between groups. |
CONCLUSIONS | Dalcetrapib showed no evidence of a pathological effect related to the arterial wall over 24 months . | Dalcetrapib showed no evidence of a pathological effect related to the arterial wall over 24 months. |
CONCLUSIONS | Moreover , this trial suggests possible beneficial vascular effects of dalcetrapib , including the reduction in total vessel enlargement over 24 months , but long-term safety and clinical outcomes efficacy of dalcetrapib need to be analysed . | Moreover, this trial suggests possible beneficial vascular effects of dalcetrapib, including the reduction in total vessel enlargement over 24 months, but long-term safety and clinical outcomes efficacy of dalcetrapib need to be analysed. |
BACKGROUND | F Hoffmann-La Roche Ltd. . | F Hoffmann-La Roche Ltd.. |
BACKGROUND | Although limitation of pronation/supination following both-bone forearm fractures in children is often attributed to an angular malunion , no clinical study has compared pronation/supination and angular malalignment of the same child by analysis of prospectively collected clinical data . | Although limitation of pronation/supination following both-bone forearm fractures in children is often attributed to an angular malunion, no clinical study has compared pronation/supination and angular malalignment of the same child by analysis of prospectively collected clinical data. |
OBJECTIVE | The purpose of this trial is to explore whether limitation of pronation/supination can be predicted by the degree of angular malalignment in children who sustained a both-bone forearm fracture . | The purpose of this trial is to explore whether limitation of pronation/supination can be predicted by the degree of angular malalignment in children who sustained a both-bone forearm fracture. |
METHODS | In four Dutch hospitals , children aged 16 years with a both-bone forearm fracture were prospectively followed up consecutive children for 6-9 months . | In four Dutch hospitals, children aged 16 years with a both-bone forearm fracture were prospectively followed up consecutive children for 6-9 months. |
METHODS | At the final follow-up , pronation/supination and angular malunion on radiographs were determined . | At the final follow-up, pronation/supination and angular malunion on radiographs were determined. |
RESULTS | Between January 2006 and August 2010 , a total of 410 children were prospectively followed up , of which 393 children were included for analysis in this study . | Between January 2006 and August 2010, a total of 410 children were prospectively followed up, of which 393 children were included for analysis in this study. |
RESULTS | The mean age of the children was 8.0 ( 3.5 ) years , of which 63 % were male and 40 % fractured their dominant arm . | The mean age of the children was 8. 0 (3. 5) years, of which 63 % were male and 40 % fractured their dominant arm. |
RESULTS | The mean time to final examination was 219 ( 51 ) days . | The mean time to final examination was 219 (51) days. |
RESULTS | Children with a metaphyseal both-bone fracture of the distal forearm with an angular malalignment of 15 had a 9-13 % chance of developing a clinically relevant limitation ( i.e. , < 50 of pronation and/or supination ) , while children with an angular malalignment of 16 had a 60 % chance . | Children with a metaphyseal both-bone fracture of the distal forearm with an angular malalignment of 15 had a 9-13 % chance of developing a clinically relevant limitation (i. e., < 50 of pronation and/or supination), while children with an angular malalignment of 16 had a 60 % chance. |
RESULTS | Children with diaphyseal both-bone forearm fractures with 5 of angular malalignment had a 13 % chance of developing a clinically relevant limitation , which showed no significant increase with a further increase of angular malalignment . | Children with diaphyseal both-bone forearm fractures with 5 of angular malalignment had a 13 % chance of developing a clinically relevant limitation, which showed no significant increase with a further increase of angular malalignment. |
CONCLUSIONS | Children who sustained a both-bone forearm fracture localised in the distal metaphysis have a higher chance of developing a clinically relevant limitation of forearm rotation in case of a more severe angular malalignment , while children with a diaphyseal both-bone forearm fracture had a moderate chance of limitation , irrespective of the severity of the angular malalignment . | Children who sustained a both-bone forearm fracture localised in the distal metaphysis have a higher chance of developing a clinically relevant limitation of forearm rotation in case of a more severe angular malalignment, while children with a diaphyseal both-bone forearm fracture had a moderate chance of limitation, irrespective of the severity of the angular malalignment. |
BACKGROUND | Laparoscopic Nissen fundoplication ( LNF ) has become established as the procedure of choice in the surgical management of the majority of patients suffering from gastroesophageal reflux disease ( GERD ) . | Laparoscopic Nissen fundoplication (LNF) has become established as the procedure of choice in the surgical management of the majority of patients suffering from gastroesophageal reflux disease (GERD). |
BACKGROUND | Postoperative paraesophageal herniation has an incidence range up to 7 % in the immediate postoperative period . | Postoperative paraesophageal herniation has an incidence range up to 7 % in the immediate postoperative period. |
OBJECTIVE | A prospective randomized trial was scheduled to study the role of posterior gastropexy , in combination with LNF , in prevention of paraesophageal herniation and improvement of postoperative results in surgical treatment of GERD . | A prospective randomized trial was scheduled to study the role of posterior gastropexy, in combination with LNF, in prevention of paraesophageal herniation and improvement of postoperative results in surgical treatment of GERD. |
METHODS | Eighty-two patients with GERD were randomized to LNF combined with ( group A , n = 40 ) or without ( group B , n = 42 ) posterior gastropexy . | Eighty-two patients with GERD were randomized to LNF combined with (group A, n = 40) or without (group B, n = 42) posterior gastropexy. |
METHODS | Subjective evaluation using disease-specific and generic questionnaires and structured interviews , and objective evaluation by endoscopy , esophageal manometry , and 24-h pH monitoring , were performed before operation , at 2 and 12 months after surgery , and then every year . | Subjective evaluation using disease-specific and generic questionnaires and structured interviews, and objective evaluation by endoscopy, esophageal manometry, and 24-h pH monitoring, were performed before operation, at 2 and 12 months after surgery, and then every year. |
METHODS | Crura approximation was performed by stitches if the diameter was less than 6 cm , or with a patch to reinforce the conventional crural closure or by tension-free technique to close the hiatus . | Crura approximation was performed by stitches if the diameter was less than 6 cm, or with a patch to reinforce the conventional crural closure or by tension-free technique to close the hiatus. |
METHODS | Posterior gastropexy ( group A ) was performed with one stitch between the posterior wall of the wrap and the crura near the arcuate ligament . | Posterior gastropexy (group A) was performed with one stitch between the posterior wall of the wrap and the crura near the arcuate ligament. |
RESULTS | Sixteen patients of group A and 15 patients of group B with concomitant abdominal diseases had simultaneous procedures [ cholecystectomy 25 , vagotomy 2 , ventral hernia repair 1 , gastric polypectomy 1 , gastric fundus diverticulectomy 1 , gastrointestinal stromal tumor ( GIST ) wedge resection 1 ] . | Sixteen patients of group A and 15 patients of group B with concomitant abdominal diseases had simultaneous procedures [cholecystectomy 25, vagotomy 2, ventral hernia repair 1, gastric polypectomy 1, gastric fundus diverticulectomy 1, gastrointestinal stromal tumor (GIST) wedge resection 1]. |
RESULTS | In mean follow-up of 48 + / - 26 months ( range 7-94 months ) , one patient of group B presented with paraesophageal herniation in the first postoperative month ( reoperation ) , while recurrent gastroesophageal reflux ( Visick III or IV ) , successfully treated by medication , was noted in three patients of group B and in one patient of group A. Only mild dysphagia , during the first two postoperative months , was noted in nine patients of group A and eight patients of group B. Six patients of each group with Barrett 's esophagus had endoscopic improvement after the second postoperative month . | In mean follow-up of 48 + / - 26 months (range 7-94 months), one patient of group B presented with paraesophageal herniation in the first postoperative month (reoperation), while recurrent gastroesophageal reflux (Visick III or IV), successfully treated by medication, was noted in three patients of group B and in one patient of group A. Only mild dysphagia, during the first two postoperative months, was noted in nine patients of group A and eight patients of group B. Six patients of each group with Barrett 's esophagus had endoscopic improvement after the second postoperative month. |
RESULTS | Visick score in groups A/B was I in 26/11 ( P < 0.0001 ) , II in 13/27 ( P = 0.037 ) , III in 1/2 ( not significant , NS ) , and IV in 0/2 . | Visick score in groups A/B was I in 26/11 (P < 0. 0001), II in 13/27 (P = 0. 037), III in 1/2 (not significant, NS), and IV in 0/2. |
RESULTS | Generally , Visick score was I or II in 39/38 in groups A/B ( 97.5 % / 90.5 % , NS ) and III or IV in 1/4 ( 2.5 % / 9.5 % , P < 0.0001 ) . | Generally, Visick score was I or II in 39/38 in groups A/B (97. 5 % / 90. 5 %, NS) and III or IV in 1/4 (2. 5 % / 9. 5 %, P < 0. 0001). |
CONCLUSIONS | LNF combined with posterior gastropexy may prevent postoperative paraesophageal or sliding herniation in surgical treatment of GERD , providing better early and long-term postoperative results . | LNF combined with posterior gastropexy may prevent postoperative paraesophageal or sliding herniation in surgical treatment of GERD, providing better early and long-term postoperative results. |
CONCLUSIONS | ( Registered Clinical Trial number : NCT00872755 . | (Registered Clinical Trial number : NCT00872755. |
CONCLUSIONS | www.clinicaltrials.gov . ) | www. clinicaltrials. gov.) |
BACKGROUND | Vitamin D deficiency is common in the general public and athletic populations and may impair skeletal muscle function . | Vitamin D deficiency is common in the general public and athletic populations and may impair skeletal muscle function. |
BACKGROUND | We therefore assessed the effects of vitamin D3 supplementation on serum 25 [ OH ] D concentrations and physical performance . | We therefore assessed the effects of vitamin D3 supplementation on serum 25 [OH] D concentrations and physical performance. |
METHODS | 30 club-level athletes were block randomised ( using baseline 25 [ OH ] D concentrations ) into one of three groups receiving either a placebo ( PLB ) , 20 000 or 40 000 IU/week oral vitamin D3 for 12 weeks . | 30 club-level athletes were block randomised (using baseline 25 [OH] D concentrations) into one of three groups receiving either a placebo (PLB), 20 000 or 40 000 IU/week oral vitamin D3 for 12 weeks. |
METHODS | Serum 25 [ OH ] D and muscle function ( 1-RM bench press and leg press and vertical jump height ) were measured presupplementation , 6 and 12 weeks postsupplementation . | Serum 25 [OH] D and muscle function (1-RM bench press and leg press and vertical jump height) were measured presupplementation, 6 and 12 weeks postsupplementation. |
METHODS | Vitamin D deficiency was defined in accordance with the US Institute of Medicine guideline ( < 50 nmol/l ) . | Vitamin D deficiency was defined in accordance with the US Institute of Medicine guideline (< 50 nmol/l). |
RESULTS | 57 % of the subject population were vitamin D deficient at baseline ( meanSD value 5124 nmol/l ) . | 57 % of the subject population were vitamin D deficient at baseline (meanSD value 5124 nmol/l). |
RESULTS | Following 6 and 12 weeks supplementation with 20 000 IU ( 7914 and 8510 nmol/l , respectively ) or 40 000 IU vitamin D3 ( 9814 and 9124 nmol/l , respectively ) , serum vitamin D concentrations increased in all participants , with every individual achieving concentrations greater than 50 nmol/l . | Following 6 and 12 weeks supplementation with 20 000 IU (7914 and 8510 nmol/l, respectively) or 40 000 IU vitamin D3 (9814 and 9124 nmol/l, respectively), serum vitamin D concentrations increased in all participants, with every individual achieving concentrations greater than 50 nmol/l. |
RESULTS | In contrast , vitamin D concentration in the PLB group decreased at 6 and 12 weeks ( 3718 and 4122 nmol/l , respectively ) . | In contrast, vitamin D concentration in the PLB group decreased at 6 and 12 weeks (3718 and 4122 nmol/l, respectively). |
RESULTS | Increasing serum 25 [ OH ] D had no significant effect on any physical performance parameter ( p > 0.05 ) . | Increasing serum 25 [OH] D had no significant effect on any physical performance parameter (p > 0. 05). |
CONCLUSIONS | Both 20 000 and 40 000 IU vitamin D3 supplementation over a 6-week period elevates serum 25 [ OH ] D concentrations above 50 nmol/l , but neither dose given for 12 weeks improved our chosen measures of physical performance . | Both 20 000 and 40 000 IU vitamin D3 supplementation over a 6-week period elevates serum 25 [OH] D concentrations above 50 nmol/l, but neither dose given for 12 weeks improved our chosen measures of physical performance. |
OBJECTIVE | To probe into the clinical therapeutic effect of acupuncture on coronary heart disease complicated by type 2 diabetes mellitus ( CDM ) and the mechanism . | To probe into the clinical therapeutic effect of acupuncture on coronary heart disease complicated by type 2 diabetes mellitus (CDM) and the mechanism. |
METHODS | Using multi-central , randomized , controlled and blind methods , 120 cases of CDM were divided into an observation group and a control group , 60 cases in each group . | Using multi-central, randomized, controlled and blind methods, 120 cases of CDM were divided into an observation group and a control group, 60 cases in each group. |
METHODS | They were treated by routine therapy for diabetes mellitus , and in the observation group , acupuncture at Quchi ( LI 11 ) , Hegu ( LI 4 ) , Xuehai ( SP 10 ) , Zusanli ( ST 36 ) , Yinlingquan ( SP 9 ) , Fenglong ( ST 40 ) . | They were treated by routine therapy for diabetes mellitus, and in the observation group, acupuncture at Quchi (LI 11), Hegu (LI 4), Xuehai (SP 10), Zusanli (ST 36), Yinlingquan (SP 9), Fenglong (ST 40). |
METHODS | Diji ( SP 8 ) , Sanyinjiao ( SP 6 ) , etc. were added with the needling method for regulating spleen-stomach ; while in the control group , acupuncture was given at Weiwanxiashu ( EX-B 3 ) , Feishu ( BL 13 ) , Pishu ( BL 20 ) , Shenshu ( BL 23 ) , Yanglingquan ( GB 34 ) , etc. . | Diji (SP 8), Sanyinjiao (SP 6), etc. were added with the needling method for regulating spleen-stomach ; while in the control group, acupuncture was given at Weiwanxiashu (EX-B 3), Feishu (BL 13), Pishu (BL 20), Shenshu (BL 23), Yanglingquan (GB 34), etc.. |
METHODS | The treatment was given twice a day in the two groups . | The treatment was given twice a day in the two groups. |
METHODS | Clinical therapeutic effects were assessed according to clinical symptoms and signs , frequency and lasting time of angina pectoris , quantity of taking Glycerol Trinitrate , blood sugar , blood lipids , urinary albumin excretion rate , urinary beta2-microglobulin , urinary monocyte chemotactic protein-1 ( MCP-1 ) , ECG , heart color Doppler , etc. . | Clinical therapeutic effects were assessed according to clinical symptoms and signs, frequency and lasting time of angina pectoris, quantity of taking Glycerol Trinitrate, blood sugar, blood lipids, urinary albumin excretion rate, urinary beta2-microglobulin, urinary monocyte chemotactic protein-1 (MCP-1), ECG, heart color Doppler, etc.. |
RESULTS | The needling method for regulating spleen-stomach not only could improve the symptoms and signs of the patient , but also could improve the degree of ST segment moving down and the function of left artrium relaxation , and had benign regulative effect on glycometabolism , lipids metabolism and urinary albumin level , with significant differences as compared with the control group ( P < 0.05 or P < 0.01 ) . | The needling method for regulating spleen-stomach not only could improve the symptoms and signs of the patient, but also could improve the degree of ST segment moving down and the function of left artrium relaxation, and had benign regulative effect on glycometabolism, lipids metabolism and urinary albumin level, with significant differences as compared with the control group (P < 0. 05 or P < 0. 01). |
RESULTS | The markedly effective rate for improvement of ECG was 50.00 % in the observation group and 13.79 % in the control group . | The markedly effective rate for improvement of ECG was 50. 00 % in the observation group and 13. 79 % in the control group. |
CONCLUSIONS | The needling method for regulating spleen-stomach can improve the damage of heart and blood vessels induced by abnormal sugar and lipids , decrease the level of urinary protein , inhibit MCP-1 excessive expression , relieve myocardial load and raise cardiac output in the patient of coronary heart disease complicated by type 2 diabetes mellitus . | The needling method for regulating spleen-stomach can improve the damage of heart and blood vessels induced by abnormal sugar and lipids, decrease the level of urinary protein, inhibit MCP-1 excessive expression, relieve myocardial load and raise cardiac output in the patient of coronary heart disease complicated by type 2 diabetes mellitus. |
BACKGROUND | Use of blue dye alone as a marker for sentinel lymph node ( SLN ) biopsy is effective , but combining it with isotope marking can improve the success rate . | Use of blue dye alone as a marker for sentinel lymph node (SLN) biopsy is effective, but combining it with isotope marking can improve the success rate. |
BACKGROUND | Use of the isotope adds extra cost and there are potential radiation hazards . | Use of the isotope adds extra cost and there are potential radiation hazards. |
BACKGROUND | The two techniques were compared in a randomized trial . | The two techniques were compared in a randomized trial. |
METHODS | Women with early breast cancer ( less than 3 cm ) and no palpable axillary nodes were recruited . | Women with early breast cancer (less than 3 cm) and no palpable axillary nodes were recruited. |
METHODS | Women older than 70 years with multicentric cancers or previous surgery to the breast or axilla were excluded . | Women older than 70 years with multicentric cancers or previous surgery to the breast or axilla were excluded. |
METHODS | Patients were randomized to either blue dye alone or combined mapping for SLN biopsy . | Patients were randomized to either blue dye alone or combined mapping for SLN biopsy. |
METHODS | All women had a level I and II axillary dissection after the SLN biopsy . | All women had a level I and II axillary dissection after the SLN biopsy. |
RESULTS | A total of 123 patients were recruited , of whom five were excluded from analysis . | A total of 123 patients were recruited, of whom five were excluded from analysis. |
RESULTS | Blue dye alone was used in 57 women and 61 had combined mapping . | Blue dye alone was used in 57 women and 61 had combined mapping. |
RESULTS | Baseline demographic data were similar in the two cohorts . | Baseline demographic data were similar in the two cohorts. |
RESULTS | The success rate of SLN biopsy was higher with combined mapping than with blue dye alone ( 100 versus 86 per cent ; P = 0.002 ) . | The success rate of SLN biopsy was higher with combined mapping than with blue dye alone (100 versus 86 per cent ; P = 0. 002). |
RESULTS | The accuracy and false-negative rate were similar ( accuracy 100 per cent for combined mapping versus 98 per cent for blue dye ; false-negative rate 0 versus 5 per cent ) . | The accuracy and false-negative rate were similar (accuracy 100 per cent for combined mapping versus 98 per cent for blue dye ; false-negative rate 0 versus 5 per cent). |
CONCLUSIONS | Combined mapping was superior to blue dye alone in identification of the SLN , but accuracy and false-negative rates were similar . | Combined mapping was superior to blue dye alone in identification of the SLN, but accuracy and false-negative rates were similar. |
BACKGROUND | Knowledge translation ( KT ) research in long-term care ( LTC ) is still in its early stages . | Knowledge translation (KT) research in long-term care (LTC) is still in its early stages. |
BACKGROUND | This protocol describes the evaluation of a multifaceted , interdisciplinary KT intervention aimed at integrating evidence-based osteoporosis and fracture prevention strategies into LTC care processes . | This protocol describes the evaluation of a multifaceted, interdisciplinary KT intervention aimed at integrating evidence-based osteoporosis and fracture prevention strategies into LTC care processes. |
METHODS | The Vitamin D and Osteoporosis Study ( ViDOS ) is underway in 40 LTC homes ( n = 19 intervention , n = 21 control ) across Ontario , Canada . | The Vitamin D and Osteoporosis Study (ViDOS) is underway in 40 LTC homes (n = 19 intervention, n = 21 control) across Ontario, Canada. |
METHODS | The primary objectives of this study are to assess the feasibility of delivering the KT intervention , and clinically , to increase the percent of LTC residents prescribed 800 IU of vitamin D daily . | The primary objectives of this study are to assess the feasibility of delivering the KT intervention, and clinically, to increase the percent of LTC residents prescribed 800 IU of vitamin D daily. |
METHODS | Eligibility criteria are LTC homes that are serviced by our partner pharmacy provider and have more than one prescribing physician . | Eligibility criteria are LTC homes that are serviced by our partner pharmacy provider and have more than one prescribing physician. |
METHODS | The target audience within each LTC home is the Professional Advisory Committee ( PAC ) , an interdisciplinary team who meets quarterly . | The target audience within each LTC home is the Professional Advisory Committee (PAC), an interdisciplinary team who meets quarterly. |
METHODS | The key elements of the intervention are three interactive educational sessions led by an expert opinion leader , action planning using a quality improvement cycle , audit and feedback reports , nominated internal champions , and reminders/point-of-care tools . | The key elements of the intervention are three interactive educational sessions led by an expert opinion leader, action planning using a quality improvement cycle, audit and feedback reports, nominated internal champions, and reminders/point-of-care tools. |
METHODS | Control homes do not receive any intervention , however both intervention and control homes received educational materials as part of the Ontario Osteoporosis Strategy . | Control homes do not receive any intervention, however both intervention and control homes received educational materials as part of the Ontario Osteoporosis Strategy. |
METHODS | Primary outcomes are feasibility measures ( recruitment , retention , attendance at educational sessions , action plan items identified and initiated , internal champions identified , performance reports provided and reviewed ) , and vitamin D ( 800 IU/daily ) prescribing at 6 and 12 months . | Primary outcomes are feasibility measures (recruitment, retention, attendance at educational sessions, action plan items identified and initiated, internal champions identified, performance reports provided and reviewed), and vitamin D (800 IU/daily) prescribing at 6 and 12 months. |
METHODS | Secondary outcomes include the proportion of residents prescribed calcium supplements and osteoporosis medications , and falls and fractures . | Secondary outcomes include the proportion of residents prescribed calcium supplements and osteoporosis medications, and falls and fractures. |
METHODS | Qualitative methods will examine the experience of the LTC team with the KT intervention . | Qualitative methods will examine the experience of the LTC team with the KT intervention. |