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9,200 | Infectious disease surveillance update | null |
9,201 | Table of Contents Page 2 | null |
9,202 | Universal Virus Detection | null |
9,203 | Molecular evolution of SARS coronavirus tracked | null |
9,204 | OP4-4 Prevalence, quantification and cut-off level of parvovirus B19 DNA in endomyocardial biopsies of cardiac patients and non-cardiac control subjects | null |
9,205 | PIV-33 Detection of oseltamivir-resistant influenza A(H1N1) viruses with H274Y mutation during 2007–2008 influenza season from central and eastern part of Turkey | null |
9,206 | Pediatric Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection – UAE | null |
9,207 | Incidence and Impact of Community Respiratory Viral Infection (CRV) in Haploidentical and Matched Sibling Donors Receiving Post-Transplant Cyclophosphamide (PTCy): A CIBMTR Analysis | There are reports of high rates of viral infections after haploidentical transplant, particularly in the setting of PTCy (HaploCy) but detailed data on incidence are lacking. We describe here the comparative incidence of community respiratory virus (CRV) infections occurring by day 180 post-transplant by donor source and their impact on outcomes including survival, relapse, chronic GVHD, and transplant related mortality (TRM) using CIBMTR registry data. The analysis included 2765 patients, all > 2 years of age, who underwent first allogeneic HCT for AML, ALL or MDS from 100 centers between 2012 and 2017 receiving either HaploCy (n=757), Matched related donor (MRD) transplant with PTCy (SibCy n= 403), and MRD transplant with calcineurin inhibitor and either MTX or MMF (SibCNI n= 1605). The cumulative incidences of CRV in the HaploCy, SibCy and SibCNI were: 3% (99% CI, 1.6-4.8), 3% (1.3-5.5) and 2.4 %(1.5-3.5) respectively at day 30 (P =0.649, NS), but notably higher at 15.5% (12.3-19), 16.2% (11.7-21.2) and 9.4 %(7.6-11.4) at 6 months (P<.001) post-transplant [Figure 1]. Identified CRV included primarily Rhinovirus, Parainfluenza, and RSV accounting for approximately 70% of all CRV reported [Table 1]. Figure 2 shows the multivariable models through 2 years post-transplant for survival, relapse, TRM, and chronic GVHD with a reference group of SibCNI without CRV infection for the main effect variable of donor type and infection. Patients in the HaploCy cohort who developed a CRV by day 180 had a higher risk of TRM [p=0.002] and inferior survival [p = 0.001] compared to the reference group. Older age, more advanced disease, and higher HCT-CI were all associated with increased mortality. The incidence of CRVs is higher for patients receiving PTCy, regardless of donor. This finding justifies further studies to understand long-term antiviral immune recovery in different donor sources and GVHD prophylaxis regimens. The higher overall mortality for HaploCy patients developing CRV infection warrants consideration for patient education and heightened awareness for clinicians, as well as long term follow up studies of such patients. |
9,208 | P.037 PCR on Dried Salivary Swab (DSS-test): a useful method for diagnosis of congenital cytomegalovirus infection? | null |
9,209 | SARS case was influenza H5N1 | null |
9,210 | International trends in integrative medicine—The Chinese perspective | null |
9,211 | Detection of human metapneumovirus in clinical specimens using a novel immunoassay | null |
9,212 | Contents page 1 | null |
9,213 | Subject index of Volume 7 | null |
9,214 | Africa, Asia, and Europe | null |
9,215 | PIV-34 A fast procedure for the detection of the new influenza virus A/H1N1 variant | null |
9,216 | P.038 Virological-molecular study of aetiological agents associated to Influenza-Like Illness (ILI) | null |
9,217 | Infectious disease surveillance update | null |
9,218 | PIV-22 Specimen quality control for respiratory pathogen detection using molecular tests: are specimens collected by community-based healthcare staff reliable? | null |
9,219 | 20.130 ISARIC – enhancing the clinical research response to epidemics | null |
9,220 | Atlas of Travel Medicine and Health | null |
9,221 | Volume contents, author and keyword indices | null |
9,222 | Infectious disease surveillance update | null |
9,223 | PIV-24 Multiple agents commonly involved in respiratory tract infections in children | null |
9,224 | PIII-2 Diagnosing human papillomavirus and human papillomavirus type 16 by real-time PCR in patient undergone to colposcopy and significance of the diagnosis | null |
9,225 | Diagnosis of Marek's disease virus in broiler chickens by histopathology and nested-PCR in Iran | null |
9,226 | News & Views | null |
9,227 | Infectious disease surveillance update | null |
9,228 | News & Views | null |
9,229 | What is ahead for health policy and technology in the 2020s? | null |
9,230 | What can we learn from MERS outbreak in South Korea? | null |
9,231 | Index to Volume 10, 2008 | null |
9,232 | Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by HMG-CoA reductase inhibitor | null |
9,233 | Influenza A detection, typing and assessment of antiviral resistance | null |
9,234 | Interferon response in murine plasmacytoid dendritic cells after SARS coronavirus infection | null |
9,235 | Evaluation of the bioMérieux easyMAG automated extraction system | null |
9,236 | Animal Disease Control: Challenges and Perspectives | null |
9,237 | Papers to Appear in Forthcoming Issues | null |
9,238 | HIV and HCV adaptation to polymorphic host responses | null |
9,239 | PI-5 The seropositivity of HBV, HCV, HIV among blood donors in Istanbul, Turkey | null |
9,240 | Poster Presentation Abstracts | null |
9,241 | 237. Lentiviral Vector Gene Transfer to Porcine Sinus and Pulmonary Airways | null |
9,242 | Respiratory Virus (RV) from Broncho Alveolar Lavage (BAL) Prior to Hematopoietic Cell Transplantation (HCT): A Strong Predictor for Allo-Immune Mediated Lung Syndromes (allo-LS) | null |
9,243 | M-IV Anti-viral resistance testing in hepatitis B virus infection | null |
9,244 | Foodborne pathogens: microbiology and molecular biology | null |
9,245 | Strategies for new problems on healthcare-associated infections in Taiwan | null |
9,246 | Carbapenem resistance in Hong Kong | null |
9,247 | Performance evaluation of real-time PCR based assays for the detection and quantitation of hepatitis B virus DNA | null |
9,248 | The epidemiology and pathogenesis of necrotizing enterocolitis | Necrotizing enterocolitis (NEC), a syndrome characterized by crepitant necrosis of the bowel, has emerged as the most common neonatal gastrointestinal emergency in many countries of the world. In the United States, NEC strikes 1 to 8% of patients admitted to neonatal intensive care units, almost all of whom are premature infants. The incidence is low in certain countries wity a low premature birth rate, e.g., Japan. Two theories of pathogenesis are: the Santulli theory, which implicates three factors: ischaemia, bacteria and substrate; and the Lawrence theory, which stresses the injurious role of bacterial toxins on the immature gut of the preterm infant. Clinical and experimental evidence support each of the theories, but neither theory can explain certain clinical phenomena, particularly the resistance to NEC manifested by more than 90% of preterm infants, who never develop the syndrome. A unifying hypothesis of pathogenesis and a mathematical model of NEC are outlined. Because clustering of cases may occur, the design of clinical trials of preventive measures for NEC must include simultaneous control infants. |
9,249 | Sessions orales | null |
9,250 | CS15-04 The Role of Polo-like Kinase 1 as a Therapeutic Target in Hepatocellular Carcinoma | null |
9,251 | EPS4.7 Cytokine dynamics in upper airway epithelial lining fluid of CF patients in relation to the status of colonization with Pseudomonas aeruginosa | null |
9,252 | Manson's tropical diseases | null |
9,253 | Infectious disease in the aging | null |
9,254 | Ocular mucins: Purification, metabolism and functions | Mucins are present at the ocular surface in both secreted and membrane-bound forms. Mucins are produced in partby the conjunctial goblet cells, and are complemented by non-globet secretions. This review focuses on secreted ocular mucins. They are present in the tear film, probably both in gel and soluble form, and play a role in lubrication and ocular defense. It is apparent that mucins are highly adapted to their functions. State of the art techniques for mucin purification and analysis are presented. Density gradient centrifugation, gel filtration, ion-exchange chromatography and agarose gel electrophoresis are discussed, together with methods of oliogosaccharide analysis. Reagents for the detection of mucin are considered in conjunction with these methods, which we have employed in the analysis of human and canine ocular mucins. The general structure of mucins is reviewed. The biosyntheas and glycosylation of ocular mucins are not yet fully understood, and are discussed in relation to currently established concepts. The impaact of disease on the nature and secretion of mucins is considered, as well as the physiological and pathological significance of mucus degradation. |
9,255 | Cross species influenza: emerging zoonosis | Emerging infection is usually an important public health concern. Within the past decade, there are many new emerging infectious diseases. An important concern is on the pandemic of those new emerging infections. The cross species infection from animal to human, zoonosis, is usually problematic and hard to manage. The well-known situations are on new emerging atypical influenza infections. In this brief article, the author discuss on three important cross species emerging influenza, H5N1 bird flu, H1N1 swine flu and H7N9 bird flu. The basic details of those new influenzas genetic aberration and the concept for surveillance and prediction of new mutation that result in the new cross species emerging zoonosis are also mentioned in this article. |
9,256 | I-60 Structural study of RNA polymerase PA subunit from an avian influenza virus | null |
9,257 | Nucleic acid amplification assays for investigation of respiratory viruses | null |
9,258 | Emerging Infections: What Have We Learned After 15 Years? | null |
9,259 | Contents page 1 | null |
9,260 | Inferno | null |
9,261 | News and insights | null |
9,262 | Economics of sustainable forest management | null |
9,263 | A duplex RT-PCR assay for detection of H9 subtype avian influenza viruses and infectious bronchitis viruses | H9 subtype avian influenza virus (AIV) and infectious bronchitis virus (IBV) are major pathogens circulating in poultry and have resulted in great economic losses due to respiratory disease and reduced egg production. As similar symptoms are elicited by the two pathogens, it is difficult for their differential diagnosis. So far, no reverse transcription-polymerase chain reaction (RT-PCR) assay has been found to differentiate between H9 AIV and IBV in one reaction. Therefore, developing a sensitive and specific method is of importance to simultaneously detect and differentiate H9 AIV and IBV. In this study, a duplex RT-PCR (dRT-PCR) was established. Two primer sets target the hemagglutinin (HA) gene of H9 AIV and the nucleocapsid (N) gene of IBV, respectively. Specific PCR products were obtained from all tested H9 AIVs and IBVs belonging to the major clades circulating in China, but not from AIVs of other subtypes or other infectious avian viruses. The sensitivity of the dRT-PCR assay corresponding to H9 AIV, IBV and mixture of H9 AIV and IBV were at a concentration of 1×10(1), 1.5×10(1) and 1.5×10(1) 50% egg infective doses (EID(50)) mL(−1), respectively. The concordance rates between the dRT-PCR and virus isolation were 99.1 and 98.2%, respectively, for detection of samples from H9N2 AIV or IBV infected chickens, while the concordance rate was 99.1% for detection of samples from H9N2 AIV and IBV co-infected chickens. Thus, the dRT-PCR assay reported herein is specific and sensitive, and suitable for the differential diagnosis of clinical infections and surveillance of H9 AIVs and IBVs. |
9,264 | 324. DNA Vaccination To Generate Chikungunya Virus-Specific Immunity | null |
9,265 | Abstracts cont. | null |
9,266 | PIV-21 Respiratory viral infections in adult patients with hematologic malignancies | null |
9,267 | Single-Agent High-Dose Melphalan as Conditioning Regimen in Autologous Hematopoietic Stem Cell Transplantation for Hodgkin's Lymphoma: Safety, and Long-Term Efficacy | null |
9,268 | 66 Incidence of Burkholderia cepacia complex infection in a Cystic Fibrosis Centre in Buenos Aires City, Argentina, from 2004 to 2014 | Burkholderia cepacia complex (Bcc) is recognized as a significant respiratory pathogen in Cystic Fibrosis (CF) patients. The identification at species level among the 18 established Bcc members is an essential tool for epidemiological studies and infection control policies. In the early 2000s the epidemiology of Burkholderia cepacia (Bcc) in Argentina was characterized by the occurrence of a B. contaminans outbreak that took place in major CF centres. This situation was quite different from other countries where B. cenocepacia and B. multivorans have been the most frequent Bcc infecting species in CF patients. Although B. contaminans outbreak was studied, little is known about the evolution of Bcc epidemiology during the last years. The aim of this study was to analyse Bcc infections in CF patients (pt) attending Hospital de Niños “R. Gutiérrez” in 3 different periods between 2004 and 2014. Incidence and distribution of Bcc species have been described. 2004–2005: Incidence 13.5% (22/163 pt). B. contaminans 55.6% (10/18), B. cepacia 16.7% (3/18), B. cenocepacia and B. seminalis 11.1% (2/18), B. multivorans 5.6% (1/18), 4 nonviable strains. 2007–2009: Incidence 6.6% (12/181 pt). B. contaminans 72.7% (8/11), B. cepacia 27.3% (3/11), 1 nonviable strain. 2012–2014: Incidence 5.4% (10/184 pt). B. contaminans 90% (9/10), B. cepacia 10% (1/10). CONCLUSION: B. contaminans remains the most frequent isolated species among the new cases of infection. Although incidence values have decreased, these results suggest the situation with B. contaminans hasn't been solved yet. More studies specially focusing on the transmission of these bacteria and the possible sources of infection are needed. |
9,269 | 25 Chronic rhinoviral infection in lung transplant recipients | null |
9,270 | Meeting report: Part III. Notes from the 20th Annual Clinical Virology Symposium, April 25–28, 2004, Clearwater Beach, FL, USA | null |
9,271 | Abstracts of the 2(nd) Global Congress on Molecular Pathology | null |
9,272 | Guidelines for the Diagnosis and Treatment of Community-Acquired Pneumonia. Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) | null |
9,273 | Impact Factors! | null |
9,274 | Free paper and oral poster abstracts | null |
9,275 | PIV-36 Performance of the Qiagen Resplex II ver. 2.0 & ver. 3.0 multiplex assays for the detection of (H1N1V) pandemic influenza A in a London teaching hospital | null |
9,276 | PIV-37 Do viral respiratory co-pathogens contribute to morbidity & mortality in an outbreak of parainfluenza type 3 in haematology-oncology patients? | null |
9,277 | Oral Presentation Abstracts | null |
9,278 | Infectious disease surveillance update | null |
9,279 | Environmental Risk and Assessment Management System of High-level Biosafety Laboratory | How to avoid the potential risk from high-level biosafety laboratories (BSL-3, BSL-4) has been highly concerned by governments all over the world. Based on the study of construction status and environmental risk of high-level biosafety laboratories and on the study of the layout structure and bio risk measures of biosafety laboratory contaminants, this paper analyzed the key point of environmental risk, and proposed the risk management system of high-level biosafety laboratories. System framework and realization process is given in the paper in order to provide reference for domestic construction of high-level biosafety laboratories and the improvement of risk emergency system. |
9,280 | OP3-3 Effect of rTGF-β on nitric oxide synthase (iNOS) AND dsRNA dependent protein kinase (PKR) during experimental influenza infection in mice | null |
9,281 | XXX Reunión de la Sociedad Española de Neumología Pediátrica | null |
9,282 | CS15-03 Prevention of HCC Related to Viral Hepatitis | null |
9,283 | Vaccines | null |
9,284 | PP-180 Elaboration of viral vaccine delivery | null |
9,285 | MERS CoV infection - ecological investigations | null |
9,286 | Acute care issues in internationally adopted children | Over the past decade there has been a dramatic increase in international adoptions in the United States. While most adopted children will have common illnesses, others may have unique medical issues as a result of the conditions in their birth country requiring a broadened differential diagnosis. Knowledge of these issues is essential in the management of these patients. This review will predominately focus on infectious disease issues commonly seen in international adoptees but will also discuss other medical conditions and some of the psychosocial issues which may be encountered by caregivers in the emergency department. |
9,287 | P176 Detection of respiratory viruses in cystic fibrosis: comparison of nasal FLOQ Swabs™ and sputum using the FilmArray® platform | null |
9,288 | Infectious disease surveillance update | null |
9,289 | Prospective Assessment of Diagnostic Infectious Disease Molecular PCR Testing with Early Fiberoptic Bronchoscopy (FOB) in the Evaluation of New Pulmonary Infiltrates in Hematopoietic Stem Cell Transplantation (HSCT) and Acute Leukemia (AL) Patients (pts) | null |
9,290 | Effectiveness of masks and respirators against respiratory infections in healthcare workers: A systematic review and meta-analysis | null |
9,291 | SS7-3 A non-redundant role of IFN-λ in antiviral defense of the intestinal tract | null |
9,292 | China receives SARS warning | null |
9,293 | Inflammatory myofibroblastic tumor in the lung with feeding vessel: mimicking a congenital lung malformation | null |
9,294 | Persistence of SARS-CoV in bat feces (Rhinolophus ferrumequinum) and implications for the ecology of SARS-CoV related viruses in nature | null |
9,295 | Untangling Alzheimer's Therapy | null |
9,296 | Can homemade fit testing solutions be as effective as commercial products? | BACKGROUND: Fit testing is used to determine whether a N95 mask will provide respiratory protection for the wearer by preventing inhalation of airborne transmitted microorganisms. National guidelines recommend that healthcare workers (HCW) who use N95 masks require fit testing. Quantitative fit testing requires the purchasing and use of fit testing solutions and associated equipment. In high volume, these solutions are expensive and may not be readily available, as was seen in the 2009 H1N1 influenza pandemic. The aim of this study was to determine how a homemade solution compared against a commercially available product and a placebo. METHODS: Afit test was performed on the same person, on three separate occasions, using three different solutions – commercial (45% sodium saccharin), homemade (to be disclosed) and placebo (water). The solution was double blinded and solutions were chosen and administered in a random order. RESULTS: Atotal of 48 people participated in this study.At the threshold testing stage, 8.3% did not taste any solution, 16.7% of people could taste the placebo, 89.6% could taste the commercial solution and 91.7% could taste the homemade solution. All persons who could taste the commercial solution could taste homemade solution. CONCLUSION: The findings of our study suggest that fit testing solutions could be made locally with a similar effect to that of commercial products, that quantitative fit testing is unreliable and that serious consideration should be given to the role of quantitative fit testing in future guidelines and standards. We recommend that this study be conducted on a larger scale to support our findings. |
9,297 | Liquorice compound beats latent herpesvirus | null |
9,298 | 65 Clinical outcomes of chronic “Prairie Epidemic Strain” Pseudomonas aeruginosa infection in adults with cystic fibrosis | OBJECTIVES: Transmissible Pseudomonas aeruginosa (PA) strains have been described in CF and may be associated with a poorer prognosis. The “Prairie Epidemic Strain” (PES) has been recently identified in up to 30% of patients at prairie-based CF centres, however, its clinical impact remains to be determined. METHODS: A cohort study of adults with cystic fibrosis from 1981–2014 was conducted and all PA isolates from clinical visits were prospectively collected. PA strain typing at clinic enrolment, and most recent was conducted by PFGE. Patients were divided into one of four cohorts: no PA, transient PA, unique chronic PA, and chronic PES. Random effects and proportional Cox hazard models were conducted for outcome of death, transplantation and FEV1% decline. RESULTS: 204 patients (54% male) with CF were analysed: 38 no PA, 20 transient PA, 103 unique PA, 43 PES. Baseline FEV1% was lowest in the chronic PES group (p = 0.002). Overall rate of FEV1% decline was –1.19%/year (95% CI: –1.41 to –0.97, p<0.001); the chronic PES group had the greatest rate of decline at –1.24%/year (p<0.001). There were a total of 42 deaths and 37 transplants through 1862 and 2050 follow-up years, respectively. The age-adjusted hazard ratio (HR) for death was not different for the PA groups compared to the no PA group. Relative to the no PA group, risk of transplant was increased in those with chronic PES (HR 9.13, CI 1.29–69, p = 0.032) compared to the no PA group. CONCLUSION: Chronic PES infection is significantly associated with a greater rate of FEV1% decline and risk of lung transplantation but not with increased risk of death compared to no PA infection. |
9,299 | Viral infections in solid transplant patients | null |