Unnamed: 0
int64 0
10k
| title
stringlengths 3
547
| abstract
stringlengths 10
122k
⌀ |
|---|---|---|
9,400 | Major infectious diseases of children in developing countries: Challenges and opportunities of today and the future | null |
9,401 | Hemophagocytic lymphohistiocytosis associated with viral infections: Diagnostic challenge and therapeutic dilemma() | Hemophagocytic lymphohistiocytosis is a frequently fatal clinicopathologic syndrome in which an uncontrolled and ineffective immune response leads to severe hyperinflammation. It may occur as either a familial disorder or a sporadic condition in association with a variety of triggers: infections, malignancies, autoimmune diseases, and acquired immune deficiencies. However, the most consistent association is with viral infections, especially Epstein–Barr virus. The main clinical features are fever, liver dysfunction, coagulation abnormalities and pancytopenia. Early diagnosis and treatment are important to reducing mortality, but the diagnosis is difficult because of the rarity of the syndrome and the lack of specificity of the clinical findings. Treatment should be directed toward treating the underlying disease and to suppressing the exaggerated inflammatory response through the use of immunosuppressive agents. |
9,402 | Trent HCV study: mortality rates and ethnic differences in outcome | null |
9,403 | Infectious diseases high on agenda in WHO leadership race | null |
9,404 | Cumulative Index 2000 | null |
9,405 | Mosaic structure of human coronavirus NL63, one thousand years of evolution | null |
9,406 | RNA virus replication | null |
9,407 | Risque de récurrence à 1 an d’une population de nourrissons ayant présenté une bronchiolite aiguë : le poids de l’allergie familiale ? | null |
9,408 | Summary Report of a Meeting on the Estimation of the Potency of Inactivated Poliovaccine: Institut Pasteur, Paris 12–13 February 1990 | null |
9,409 | Keyword Index | null |
9,410 | Forthcoming topics | null |
9,411 | M-II Quality control in a molecular virology laboratory | null |
9,412 | CS15.2 Drug design and development against EV71 and other enteroviruses | null |
9,413 | Enteric virus detection and identification with a universal virus discovery assay | null |
9,414 | 634: Clinical Outcome of Brazilian Lung Transplant Recipients after Respiratory Virus Infections | null |
9,415 | EPS4.6 Inherent differences in multiple breath washout (MBW) using N(2) and SF(6) demonstrated by simultaneous analysis with respiratory mass spectrometry (RMS) | null |
9,416 | Viral burden in acute respiratory tract infections in hospitalized children in the wet and dry zones of Sri Lanka | null |
9,417 | EPS4.3 Differential sensitivity of outcome measures that assess progression of mild CF lung disease in school age children | null |
9,418 | The spread of filthy lucre and disease | null |
9,419 | Author/subject index | null |
9,420 | Infectious disease surveillance update | null |
9,421 | Spectre of SARS still looms | null |
9,422 | A Novel Therapeutic and Prophylactic Vaccine against Tuberculosis Using the Cynomolgus Monkey Model and Mouse Model | We have developed a novel tuberculosis (TB) vaccine; a combination of the DNA vaccines expressing mycobacterial heat shock protein 65 (HSP65) and interleukin 12 (IL-12) delivered by the hemagglutinating virus of Japan (HVJ)-envelope and –liposome (HSP65 + IL-12/HVJ). This vaccine provided remarkable protective efficacy in mouse model compared to the BCG. This vaccine also provided therapeutic efficacy against multi-drug resistant TB (MDR-TB) and extremely drug resistant TB (XDR-TB) in murine models. Furthermore, we extended our studies to a cynomolgus monkey model, which is currently the best animal model of human tuberculosis. This novel vaccine provided a higher level of the protective efficacy than BCG based upon the assessment of mortality. The BCG prime and HSP65 + IL-12/HVJ vaccine (boost) by the prime-boost method showed a synergistic prophylactic effect in the monkey. Furthermore, this vaccine exerted therapeutic efficacy (100% survival) and augmentation of immune responses in the TB-infected monkeys.HVJ-Envelope/HSP65 DNA + IL-12 DNA vaccine increased the body weight of TB-infected monkeys, improved the ESR, and augmented the immuneresponses (proliferation of PBL and IL-2 production). The enhancement of IL-2 production from monkeys treated with this vaccine was correlated with the therapeutic efficacy of the vaccine. These data indicate that our novel DNA vaccine might be useful against Mycobacterium tuberculosis including XDR-TB and MDR-TB for human therapeutic clinical trials. |
9,423 | Cytomegalovirus monitoring in allogeneic haemopoietic stem cell transplant recipients | null |
9,424 | P.059 Detection of Epstein–Barr Virus DNA in respiratory specimens from patients with chronic obstructive pulmonary disease by quantitative PCR | null |
9,425 | Family syndromes of cancer of female reproductive organs in Chernivtsi region | null |
9,426 | Rapid Recovery of Classical Swine Fever Virus Directly from Cloned cDNA | The reverse genetics for classical swine fever virus (CSFV) is currently based on the transfection of in vitro transcribed RNA from a viral genomic cDNA clone, which is inefficient and time-consuming. This study was aimed to develop an improved method for rapid recovery of CSFV directly from cloned cDNA. Full-length genomic cDNA from the CSFV Shimen strain, which was flanked by a T7 promoter, the hepatitis delta virus ribozyme and T7 terminator sequences, was cloned into the low-copy vector pOK12, producing pOKShimen-RzTΦ. Direct transfection of pOKShimen-RzTΦ into PK/T7 cells, a PK-15-derived cell line stably expressing bacteriophage T7 RNA polymerase, allowed CSFV to be rescued rapidly and efficiently, i.e., at least 12 h faster and 31.6-fold greater viral titer when compared with the in vitro transcription-based rescue system. Furthermore, the progeny virus rescued from PK/T7 cells was indistinguishable, both in vitro and in vivo, from its parent virus and the virus rescued from classical reverse genetics. The reverse genetics based on intracellular transcription is efficient, convenient and cost-effective. The PK/T7 cell line can be used to rescue CSFV directly from cloned cDNA and it can also be used as an intracellular transcription and expression system for studying the structure and function of viral genes. |
9,427 | Travellers' Vaccines (2004) | null |
9,428 | Heterologous recombination in the segmented dsRNA genome of bacteriophage Φ6 | The genome of bacteriophage Φ6 is composed of three unique segments of double-stranded RNA packaged within a procapsid. One segment can recombine with another in regions that share little sequence similarity. Although the recombination is therefore heterologous, the crossover points usually consist of two to six identical nucleotides. The frequency of recombinants is enhanced by conditions that prevent or hinder the minus strand synthesis of a single plus strand segment. Recombination serves as a repair system as well as a means of changing the genetic structure of the virus. The reaction can be studied in an in-vitro packaging and replication system involving purified procapsids and ssRNA. Although there are striking differences in the mechanisms of recombination in RNA viruses, there are also strong similarities. All seem to use a copy-choice template switching action for recombination. The Φ6 system is a useful model for the recombination of other segmented double-stranded RNA viruses such as the Reoviridae. |
9,429 | From SARS to MERS and Ebola | null |
9,430 | Editor's Choice | null |
9,431 | Abstracts cont. | null |
9,432 | XXXI Reunión de la SOCIEDAD ESPAÑOLA DE NEUMOLOGÍA PEDIÁTRICA: Jaén, 7, 8 y 9 de Mayo de 2009 | null |
9,433 | Association between influenza and pneumococcal carriage in patients with severe acute respiratory infection in Malawi | null |
9,434 | Index to Volume 7, 2005 | null |
9,435 | Using the Incidence Decay and Exponential Adjustment (IDEA) model to understand transmission dynamics of MERS-CoV in a camel herd | null |
9,436 | P941 – P1197 | null |
9,437 | IF-02 Successful Control of Influenza Using Stockpile of Tamiflu® during 2003/2004 SARS Period | null |
9,438 | Le cardiologue et l’infection à Ebola virus | null |
9,439 | Serological investigation of MERS-CoV in humans between 2011-2016, Jeddah, Saudi Arabia | null |
9,440 | Phylogenetics, virus evolution and molecular epidemiology | null |
9,441 | US government (depository items) | null |
9,442 | ABCD (who's who) | null |
9,443 | 27 Clinical features associated with Coronavirus infections: A prospective and hospital-based study | null |
9,444 | OP4-2 Timely diagnosis of respiratory tract infections: evaluation of the performance of the respifinder assay compared to the RVP assay | null |
9,445 | 554. A Candidate SARS-Associated Coronavirus Vaccine Elicits Broad Immunity in Monkeys | null |
9,446 | PIV-23 Clinical usefulness of HMPV quantitative PCR in paediatric respiratory samples | null |
9,447 | EPS4.5 Epidemiology of viral respiratory tract infections in a paediatric CF centre | null |
9,448 | Forthcoming Articles | null |
9,449 | Neonatal Nursing: A Global Affair | null |
9,450 | PP-085 Large scale protein expressions for antigenomics studies of respiratory viruses | null |
9,451 | Infectious disease surveillance update | null |
9,452 | Research Update | null |
9,453 | Cumulative Keyword Index | null |
9,454 | India - National disaster and epidemic preparedness | null |
9,455 | JOGC Update Page | null |
9,456 | The gardner lecture: New respiratory viruses: from viral RNA to symptomatic patients | null |
9,457 | 151* Sino-pulmonary pairs of mucoid and non-mucoid Pseudomonas aeruginosa isolates from cystic fibrosis patients with chronic airways infection have similar gene expression profiles | null |
9,458 | ProMED update | null |
9,459 | Infectious diseases in the 21(st) century: increasing threats, fewer new treatments and a premium on prevention | null |
9,460 | Table of Contents / barcode | null |
9,461 | WHA adopts new International Health Regulations | null |
9,462 | PIII-1 Frequency and genotyping of human papillomavirus in pap smear samples | null |
9,463 | Abstracts cont. | null |
9,464 | SARS survivors fail to recover by 1 year, say researchers | null |
9,465 | OP4-1 Surveillance and oseltamivir resistance of human influenza A virus in Turkey during the 2007–2008 season | null |
9,466 | Early evolution of hepatitis C virus (HCV) quasispecies after liver transplantation | null |
9,467 | Infectious disease surveillance update | null |
9,468 | Microbiology of the nasopharynx in children hospitalized with suspected pulmonary tuberculosis | null |
9,469 | I-46 Clinical management of severe respiratory infections in adult hospitalized patients | null |
9,470 | 67 CF patients with a declining FEV(1): At risk for acquisition of Burkholderia cepacia complex infection? | INTRODUCTION: Burkholderia cepacia complex (Bcc) infection is considered to be associated with worsening of CF lung disease. Patient to patient spread has been reported, however mechanisms of acquisition of Bcc are not well understood. Method: Data from the Belgian CF Registry (year 2000–2010) were collected. Inclusions: Bcc infected patients with entries on lung function in at least 1 y before and 3 y after Bcc acquisition. For each case, we included 2 controls, matched for age at the index year (year of first Bcc infection), pancreatic status, sex. Cumulative data up to 2 years before index year were compared to values obtained after infection using Rank sum test. Rate of decline in lung function was adjusted for baseline lung function, age, sex. RESULTS: Bcc prevalence in CF is low in Belgium (<3%). 183 patients were included: 61 cases, 122 controls. 59% were F508del homozygous. Mean age in cases was 20.9 y (SD 10.5) vs 20.3 y (SD 10.3) in controls. Among the Bcc, 54% were unspecified, 31% were B. multivorans. Mean FEV(1) at index year was 65.2% (SD 24.9) in cases vs 73.1 (SD 26.9) in controls (p = 0.07). FEV(1) decline before index year was significantly higher in cases (–1.7%, SD 0.5) compared to controls (–1.0%, SD 0.3) (p = 0.002). FEV(1) slopes were comparable in the period after index year (–1.1%, SD 0.5, in cases vs –0.99%, SD 0.4, p = 0.24). CONCLUSION: Our results suggest that a declining FEV(1) precedes acquisition of Bcc and may be a risk factor. After acquisition, lung function decline was comparable in Bcc infected and uninfected patients. These results should be interpreted with caution, since registry data are collected retrospectively and bear a risk of incompleteness or inaccuracy. |
9,471 | Highlights from the 20th ECCMID | null |
9,472 | News in brief | null |
9,473 | The dictionary of virology | null |
9,474 | Infectious disease surveillance update | null |
9,475 | Cumulative Keyword Index for Volumes 114-117 | null |
9,476 | SARS in context: memory, history, policy | null |
9,477 | ProMED Update | null |
9,478 | 149* 2009 H1N1 influenza A in cystic fibrosis patients. A French collaborative study | null |
9,479 | Coping with pain: The impact of SARS visitation restrictions on patients' perception of nursing support | null |
9,480 | Virus detection made easy: Nanotechnology | null |
9,481 | SARS source back on the menu | null |
9,482 | PIV-28 Detection of respiratory viruses by molecular methods – a way of improving conventional diagnosis | null |
9,483 | Travel Medicine | null |
9,484 | EPS4.4 Correlation between long-term changes in LCI, FEV(1) and CFCT score in children with cystic fibrosis | null |
9,485 | Middle East respiratory syndrome (MERS 2012): roles of clinical pathology laboratory for screening and diagnosis | null |
9,486 | Effective Intervention and Vaccination Strategies Against Nosocomial Infection Based on Network Analysis | null |
9,487 | A novel coronavirus emerges | null |
9,488 | Root growth and cyclin control: Doerner, P., Jørgensen, J-E., You, R., Steppuhn, J. and Lamb, C. (1996) Control of root growth and development by cyclin expression, Nature 380, 520–523 | null |
9,489 | Bayer molecular: viral load testing today and tomorrow | null |
9,490 | Peter Salama | null |
9,491 | Middle East respiratory syndrome coronavirus conference | null |
9,492 | Pathogen identification in travelling patients with severe acute respiratory infections from the Middle East to the Philippines, 2014–2016 | null |
9,493 | IF-01 Rapid and Sensitive Detection of Various Influenza Virus Subtypes Using SAT | null |
9,494 | Author index volume 7 international journal of infectious diseases | null |
9,495 | Association for Molecular Pathology 2006 Annual Meeting Abstracts | null |
9,496 | Infectious disease surveillance update | null |
9,497 | Herpes simplex (HSV) viral load in bronchoalveolar lavage: risk factors and clinical outcome | null |
9,498 | TOC | null |
9,499 | Respiratory Pathogen Evaluation for Lipschütz Ulcer | null |