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Do amniotic membrane transplantation to reconstruct the conjunctival surface in cases of chemical burn?

Preserved amniotic membrane transplantation was performed in 6 patients (6 eyes) having symblepharon and fornix insufficiency due to chemical burn . Amniotic membranes were sutured to the intact conjunctiva after the fibrotic tissue was excised . The cases were followed up for 4-24 months . The mean follow-up period (10+/-7.37 months) was achieved in 5 patients without recurrence and with mild fibrosis .

Preserved human amniotic membrane transplantation is a good alternative treatment method for conjunctival surface reconstruction in those cases with some healthy peripheral conjunctival tissue.

yes

### Human: Preserved amniotic membrane transplantation was performed in 6 patients (6 eyes) having symblepharon and fornix insufficiency due to chemical burn . Amniotic membranes were sutured to the intact conjunctiva after the fibrotic tissue was excised . The cases were followed up for 4-24 months . The mean follow-up period (10+/-7.37 months) was achieved in 5 patients without recurrence and with mild fibrosis . Do amniotic membrane transplantation to reconstruct the conjunctival surface in cases of chemical burn?### Assistant: Preserved human amniotic membrane transplantation is a good alternative treatment method for conjunctival surface reconstruction in those cases with some healthy peripheral conjunctival tissue.

Preserved human amniotic membrane transplantation is a good alternative treatment method for conjunctival surface reconstruction in those cases with some healthy

Do increased TRPM6 expression in atrial fibrillation patients contribute to atrial fibrosis?

The right atrial tissue samples were obtained from 64 patients with rheumatic heart diseases who underwent heart valve replacement surgery . The mRNA levels of myocardial fibrosis markers (CTGF, TGF-beta 1, Collagen I/III) in AF group increased significantly compared to the SR group . TRPM6 mRNA and protein levels in AF were elevated markedly in comparison with SR group (P<0.01), and TRP6 mRNA levels were also elevated markedly compared to SR .

These findings revealed that increased TRPM6 mRNA and protein levels may contribute to atrial fibrosis, and suggested that TRPM6 might be involved in AF development by promoting fibrogenesis.

yes

### Human: The right atrial tissue samples were obtained from 64 patients with rheumatic heart diseases who underwent heart valve replacement surgery . The mRNA levels of myocardial fibrosis markers (CTGF, TGF-beta 1, Collagen I/III) in AF group increased significantly compared to the SR group . TRPM6 mRNA and protein levels in AF were elevated markedly in comparison with SR group (P<0.01), and TRP6 mRNA levels were also elevated markedly compared to SR . Do increased TRPM6 expression in atrial fibrillation patients contribute to atrial fibrosis?### Assistant: These findings revealed that increased TRPM6 mRNA and protein levels may contribute to atrial fibrosis, and suggested that TRPM6 might be involved in AF development by promoting fibrogenesis.

Increased TRPM6 mRNA and protein levels may contribute to atrial fibrosis, according to research . The protein levels are found to be

Do changes in mood predict disease activity and quality of life in patients with psoriasis following emotional disclosure?

The study examined the effects of emotional disclosure (ED) intervention on both disease severity and quality of life in patients with psoriasis . Disease severity, quality and mood were assessed at baseline and at 2, 8, and 12 weeks postintervention . The study found no differences in the magnitude of improvement between the groups . However, predictors of improvement were found to differ, with seasonal variation approaching significance for control patients . The results were published in The Lancet journal, published in March 2013 .

Changes in mood following ED predicted improvements in disease severity in patients with psoriasis. However, the degree of improvement did not differ between intervention and control patients.

yes

### Human: The study examined the effects of emotional disclosure (ED) intervention on both disease severity and quality of life in patients with psoriasis . Disease severity, quality and mood were assessed at baseline and at 2, 8, and 12 weeks postintervention . The study found no differences in the magnitude of improvement between the groups . However, predictors of improvement were found to differ, with seasonal variation approaching significance for control patients . The results were published in The Lancet journal, published in March 2013 . Do changes in mood predict disease activity and quality of life in patients with psoriasis following emotional disclosure?### Assistant: Changes in mood following ED predicted improvements in disease severity in patients with psoriasis. However, the degree of improvement did not differ between intervention and control patients.

Changes in mood following ED predicted improvements in disease severity in patients with psoriasis . However, the degree of improvement did not differ between

Does hypoxic preconditioning protect cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway?

AMPK plays a critical role in hypoxic preconditioning (HPC) protecting cardiomyocytes against hypoxia reoxygenation (H/R) injury . HPC significantly increased the expression of p-AMPK (Thr172), p-eNOS (Ser1177) expression, which was abolished by AMPK inhibition or eNOS inhibition . AMPK activator metformin mimicked the effects of HPC in part . Hpc attenuated the oxidative stress by increasing the SOD activity and decreasing the ROS level .

These results indicated that HPC protects H9c2 cells against H/R injury by reducing oxidative stress partly via AMPK/eNOS/PGC-1α signaling pathway.

yes

### Human: AMPK plays a critical role in hypoxic preconditioning (HPC) protecting cardiomyocytes against hypoxia reoxygenation (H/R) injury . HPC significantly increased the expression of p-AMPK (Thr172), p-eNOS (Ser1177) expression, which was abolished by AMPK inhibition or eNOS inhibition . AMPK activator metformin mimicked the effects of HPC in part . Hpc attenuated the oxidative stress by increasing the SOD activity and decreasing the ROS level . Does hypoxic preconditioning protect cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway?### Assistant: These results indicated that HPC protects H9c2 cells against H/R injury by reducing oxidative stress partly via AMPK/eNOS/PGC-1α signaling pathway.

HPC protects H9c2 cells against H/R injury by reducing oxidative stress partly via AMPK/eNOS/PG

Is the NFKB1 ( g.-24519delATTG ) variant associated with necrotizing enterocolitis ( NEC ) in premature infants?

In a cohort of 271 infants, 15 (5.6%) developed NEC, and five died from it . Infants with NEC were less mature (P < 0.001), and were more likely to be African-American (P = 0.007) SNPs in the TLR2, TLR4,TLR4 and TLR5, TLr9, IRAK1, and TIRAP genes were not associated with NEC . The NFKB1 (g.-24519delATTG) variant was present in all infants with NEC but only in 65% of infants without NEC .

These data suggest that TLR genetic variants can alter susceptibility to NEC in VLBW infants and support the hypothesis that genetically programmed differences in the innate immune response contribute to NEC pathogenesis.

yes

### Human: In a cohort of 271 infants, 15 (5.6%) developed NEC, and five died from it . Infants with NEC were less mature (P < 0.001), and were more likely to be African-American (P = 0.007) SNPs in the TLR2, TLR4,TLR4 and TLR5, TLr9, IRAK1, and TIRAP genes were not associated with NEC . The NFKB1 (g.-24519delATTG) variant was present in all infants with NEC but only in 65% of infants without NEC . Is the NFKB1 ( g.-24519delATTG ) variant associated with necrotizing enterocolitis ( NEC ) in premature infants?### Assistant: These data suggest that TLR genetic variants can alter susceptibility to NEC in VLBW infants and support the hypothesis that genetically programmed differences in the innate immune response contribute to NEC pathogenesis.

TLR genetic variants can alter susceptibility to NEC in VLBW infants . These data suggest that TLRs genetic variants may alter susceptibility .

Is serum creatine phosphokinase helpful in distinguishing generalized tonic-clonic seizures from psychogenic nonepileptic seizures and vasovagal syncope?

Serum serum creatine phosphokinase (CPK) concentration was measured 12-15 h after the attack in all patients and at one time in the control group . Serum CPK concentration had a sensitivity of 75% and specificity of 86% for diagnosis of GTCS . The PNES, VVS, and control groups did not statistically significantly differ with respect to CPK concentrations . There were no significant differences between the four groups with regard to age and sex . The study was conducted at Namazi Hospital in Iran .

In patients with a recent loss of consciousness and abnormal movements, serum CPK concentration is a useful, practical, and relatively accurate parameter to assist in the differentiation of epileptic seizures from either VVS or PNES.

yes

### Human: Serum serum creatine phosphokinase (CPK) concentration was measured 12-15 h after the attack in all patients and at one time in the control group . Serum CPK concentration had a sensitivity of 75% and specificity of 86% for diagnosis of GTCS . The PNES, VVS, and control groups did not statistically significantly differ with respect to CPK concentrations . There were no significant differences between the four groups with regard to age and sex . The study was conducted at Namazi Hospital in Iran . Is serum creatine phosphokinase helpful in distinguishing generalized tonic-clonic seizures from psychogenic nonepileptic seizures and vasovagal syncope?### Assistant: In patients with a recent loss of consciousness and abnormal movements, serum CPK concentration is a useful, practical, and relatively accurate parameter to assist in the differentiation of epileptic seizures from either VVS or PNES.

serum CPK concentration is a useful, practical, and relatively accurate parameter to assist in the differentiation of epileptic seizures from either VVS

Does statins in the last six months of life : a recognizable , life-limiting condition decrease their use?

Some have advocated discontinuing statins in patients with life-limiting conditions . The extent of statin use at the end of life has yet to be described . Whether statin prescribing may already be influenced by the presence of a recognizable, life limiting condition is unknown . There was no significant difference in the time off statins between cases and controls . Study was sufficiently powered to detect one, but the study was sufficiently power-limited to detect a difference . Back to Mail Online home . Back To the page you came from .

These findings underscore a missed opportunity to reduce the therapeutic burden upon dying patients and limit health care spending.

no

### Human: Some have advocated discontinuing statins in patients with life-limiting conditions . The extent of statin use at the end of life has yet to be described . Whether statin prescribing may already be influenced by the presence of a recognizable, life limiting condition is unknown . There was no significant difference in the time off statins between cases and controls . Study was sufficiently powered to detect one, but the study was sufficiently power-limited to detect a difference . Back to Mail Online home . Back To the page you came from . Does statins in the last six months of life : a recognizable , life-limiting condition decrease their use?### Assistant: These findings underscore a missed opportunity to reduce the therapeutic burden upon dying patients and limit health care spending.

These findings underscore a missed opportunity to reduce the therapeutic burden upon dying patients and limit health care spending .

Is 3,4-methylenedioxymethamphetamine self-administration abolished in serotonin transporter knockout mice?

The neurobiological mechanism underlying the reinforcing effects of 3,4-methylenedioxymethamphetamine (MDMA) remains unclear . The aim of the present study was to determine the contribution of the serotonin transporter (SERT) in MDMA self-administration behavior by using knockout (KO) mice deficient in SERT . None of the MDMA doses tested maintained intravenous self-Administration in KO animals, whereas WT mice acquired responding for MDMA . MDMA increased DA extracellular levels to a similar extent in the NAC of WT and KO mice .

These findings provide evidence for the specific involvement of SERT in MDMA reinforcing properties.

yes

### Human: The neurobiological mechanism underlying the reinforcing effects of 3,4-methylenedioxymethamphetamine (MDMA) remains unclear . The aim of the present study was to determine the contribution of the serotonin transporter (SERT) in MDMA self-administration behavior by using knockout (KO) mice deficient in SERT . None of the MDMA doses tested maintained intravenous self-Administration in KO animals, whereas WT mice acquired responding for MDMA . MDMA increased DA extracellular levels to a similar extent in the NAC of WT and KO mice . Is 3,4-methylenedioxymethamphetamine self-administration abolished in serotonin transporter knockout mice?### Assistant: These findings provide evidence for the specific involvement of SERT in MDMA reinforcing properties.

These findings provide evidence for the specific involvement of SERT in MDMA reinforcing properties .

Does depression during gestation in adolescent mothers interfere with neonatal neurobehavior?

To compare the neurobehavior of neonates born to adolescent mothers with and without depression during gestation, this study included healthy term neonates . Infants born to mothers with depression during pregnancy were compared to those born to adolescents without psychiatric disorders . Infant neurobehavioral outcomes were analyzed by ANOVA adjusted for confounders . Infanted of mothers with depressed had smaller head circumferences . Infanting of mothers without depression had smaller heads circumfusions . Infanteants of depressed mothers were found to be worse in arousal, excitability, lethargy, hypotonicity and signs of stress .

Infants born to adolescent mothers with depression exhibit some behavioral changes in the first days of life. These changes are associated with infant sex, gestational age, type of anesthesia, mode of delivery, and head circumference.

yes

### Human: To compare the neurobehavior of neonates born to adolescent mothers with and without depression during gestation, this study included healthy term neonates . Infants born to mothers with depression during pregnancy were compared to those born to adolescents without psychiatric disorders . Infant neurobehavioral outcomes were analyzed by ANOVA adjusted for confounders . Infanted of mothers with depressed had smaller head circumferences . Infanting of mothers without depression had smaller heads circumfusions . Infanteants of depressed mothers were found to be worse in arousal, excitability, lethargy, hypotonicity and signs of stress . Does depression during gestation in adolescent mothers interfere with neonatal neurobehavior?### Assistant: Infants born to adolescent mothers with depression exhibit some behavioral changes in the first days of life. These changes are associated with infant sex, gestational age, type of anesthesia, mode of delivery, and head circumference.

Infants born to adolescent mothers with depression exhibit behavioral changes in the first days of life . These changes are associated with infant sex, gest

Does comparative study of ultrasound-guided abdominal field block versus port infiltration in laparoscopic cholecystectomies for post-operative pain relief?

Post-operative pain is a major concern for day care surgeries like laparoscopic cholecystectomy . This study aimed to compare the efficacy of ultrasound guided abdominal field blocks (USAFB) with port site infiltrations for post-operative analgesia in terms of quality of pain relief, opioid consumption and patient satisfaction . The overall fentanyl consumption in patients receiving port infiltrations was approximately twice (200 ΁ 100 μg) as compared to patients in USAFB group (120 ΁ 74 μg) (P < 0.0001)

Superior post-operative analgesia was observed with USAFB which may help in minimising opioid-related adverse effects and facilitating faster recovery.

yes

### Human: Post-operative pain is a major concern for day care surgeries like laparoscopic cholecystectomy . This study aimed to compare the efficacy of ultrasound guided abdominal field blocks (USAFB) with port site infiltrations for post-operative analgesia in terms of quality of pain relief, opioid consumption and patient satisfaction . The overall fentanyl consumption in patients receiving port infiltrations was approximately twice (200 ΁ 100 μg) as compared to patients in USAFB group (120 ΁ 74 μg) (P < 0.0001) Does comparative study of ultrasound-guided abdominal field block versus port infiltration in laparoscopic cholecystectomies for post-operative pain relief?### Assistant: Superior post-operative analgesia was observed with USAFB which may help in minimising opioid-related adverse effects and facilitating faster recovery.

USAFB may help in minimising opioid-related adverse effects and facilitating faster recovery .

Does sphingosine kinase 1 mediate head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1?

Sphingosine kinase1 (SphK1) is emerging as a key player in HNSCC pathology . SphK1 expression is elevated in cells with an invasive phenotype as compared to non-invasive phenotype . S1P1 knockdown reduced IL-6/STAT3 signaling, representing another pathway by which SphK 1/S1P regulates invasion, authors say . S2P1 knocked down by S1p1 reduces IL-4/ STAT3 signaling .

Taken together, our data suggest that SphK1 sits at the hub of multiple key signaling cascades, all which have been implicated in the regulation of invasiveness, making SphK1 an attractive target for the development of HNSCC therapies.

yes

### Human: Sphingosine kinase1 (SphK1) is emerging as a key player in HNSCC pathology . SphK1 expression is elevated in cells with an invasive phenotype as compared to non-invasive phenotype . S1P1 knockdown reduced IL-6/STAT3 signaling, representing another pathway by which SphK 1/S1P regulates invasion, authors say . S2P1 knocked down by S1p1 reduces IL-4/ STAT3 signaling . Does sphingosine kinase 1 mediate head & neck squamous cell carcinoma invasion through sphingosine 1-phosphate receptor 1?### Assistant: Taken together, our data suggest that SphK1 sits at the hub of multiple key signaling cascades, all which have been implicated in the regulation of invasiveness, making SphK1 an attractive target for the development of HNSCC therapies.

SphK1 is an attractive target for the development of HNSCC therapies .

Is a meat , processed meat , and French fries dietary pattern associated with high allostatic load in Puerto Rican older adults?

Diet has been proposed as a contributor to allostatic load, a composite measure of physiological dysregulation . Data from Boston Puerto Rican Health Study (n=1,117; aged 45 to 75 years) was used to run linear and logistic regression models . Participants in the highest quintile of the meat and french fries pattern had significantly higher allostatics load score than those in the lowest quintile (mean 4.3±0.11 vs. 3.9± 0.12, P=0.030) The traditional pattern of Puerto Rican foods (rice, beans, and oils), or "sweets," was not associated .

A meat, processed meat, and french fries dietary pattern may contribute to the deregulation of multiple physiologic parameters in Puerto Rican adults. Efforts to limit consumption of this pattern may help prevent further cumulative physiological dysregulation in this high risk population.

yes

### Human: Diet has been proposed as a contributor to allostatic load, a composite measure of physiological dysregulation . Data from Boston Puerto Rican Health Study (n=1,117; aged 45 to 75 years) was used to run linear and logistic regression models . Participants in the highest quintile of the meat and french fries pattern had significantly higher allostatics load score than those in the lowest quintile (mean 4.3±0.11 vs. 3.9± 0.12, P=0.030) The traditional pattern of Puerto Rican foods (rice, beans, and oils), or "sweets," was not associated . Is a meat , processed meat , and French fries dietary pattern associated with high allostatic load in Puerto Rican older adults?### Assistant: A meat, processed meat, and french fries dietary pattern may contribute to the deregulation of multiple physiologic parameters in Puerto Rican adults. Efforts to limit consumption of this pattern may help prevent further cumulative physiological dysregulation in this high risk population.

A meat, processed meat, and french fries dietary pattern may contribute to the deregulation of multiple physiologic parameters in Puerto Rican adults . Eff

Does a simple algorithm reduce computed tomography use in the diagnosis of appendicitis in children?

A diagnostic algorithm for appendicitis in children was created to reduce computed tomography use owing to the risk of cancer from radiation exposure and cost of CT . CT utilization decreased from 39% to 18% after implementation . The negative appendectomy rate increased from 9% to 11% (P = .59) Use of CT did not impact risk of negative appendectectecture (P) = .64). Use of the algorithm did not . impact the risk . of negative . appendectomy (P: .64)

Utilization of CT was significantly reduced after implementation of a diagnostic algorithm for appendicitis without impacting diagnostic accuracy. Given the concern for increased risk of cancer after CT, these results support use of an algorithm in children with suspected appendicitis.

yes

### Human: A diagnostic algorithm for appendicitis in children was created to reduce computed tomography use owing to the risk of cancer from radiation exposure and cost of CT . CT utilization decreased from 39% to 18% after implementation . The negative appendectomy rate increased from 9% to 11% (P = .59) Use of CT did not impact risk of negative appendectectecture (P) = .64). Use of the algorithm did not . impact the risk . of negative . appendectomy (P: .64) Does a simple algorithm reduce computed tomography use in the diagnosis of appendicitis in children?### Assistant: Utilization of CT was significantly reduced after implementation of a diagnostic algorithm for appendicitis without impacting diagnostic accuracy. Given the concern for increased risk of cancer after CT, these results support use of an algorithm in children with suspected appendicitis.

CT was significantly reduced after implementation of a diagnostic algorithm for appendicitis without impacting diagnostic accuracy . Given the concern for increased risk of cancer

Is appropriate antibiotic utilization in seniors prior to hospitalization for community-acquired pneumonia associated with decreased in-hospital mortality?

We used administrative data for seniors (age 61 years and over) for Alberta, Canada from 1 April 1994 to 31 March 1999 . In about 43% of hospitalizations (n = 9034), a physician was consulted prior to hospital admission . Antibiotics were dispensed to 31% of those with a prior physician visit and in about 72%, the antibiotic choice was deemed appropriate . The choice of an appropriate antibiotic as opposed to an inappropriate antibiotic resulted in a 2.6% absolute and 38% relative mortality reduction .

Choosing an appropriate outpatient antibiotic in accordance with published expert opinion guidelines compared with inappropriate antibiotic prescriptions decreased hospital mortality in patients subsequently hospitalized for community-acquired pneumonia.

yes

### Human: We used administrative data for seniors (age 61 years and over) for Alberta, Canada from 1 April 1994 to 31 March 1999 . In about 43% of hospitalizations (n = 9034), a physician was consulted prior to hospital admission . Antibiotics were dispensed to 31% of those with a prior physician visit and in about 72%, the antibiotic choice was deemed appropriate . The choice of an appropriate antibiotic as opposed to an inappropriate antibiotic resulted in a 2.6% absolute and 38% relative mortality reduction . Is appropriate antibiotic utilization in seniors prior to hospitalization for community-acquired pneumonia associated with decreased in-hospital mortality?### Assistant: Choosing an appropriate outpatient antibiotic in accordance with published expert opinion guidelines compared with inappropriate antibiotic prescriptions decreased hospital mortality in patients subsequently hospitalized for community-acquired pneumonia.

Choosing an appropriate outpatient antibiotic in accordance with published expert opinion guidelines decreased hospital mortality in patients subsequently hospitalized for community-acquired pneumonia .

Is epithelial basement membrane thickening related to TGF-Beta 1 expression in children with chronic respiratory diseases?

The complex structural changes of bronchial mucosa, known as remodelling, have been considered unique and typical for asthma . The aim of this study was to compare basement membrane (BM) thickness and the number of transforming growth factor beta 1 (TGF-β1) positive epithelial cells in children with asthma, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and healthy controls . A positive correlation was observed in all groups including controls . There was no difference in these parameters between asthma, CF and PCD .

Increased BM thickness and number of TGF-β1 positive epithelial cells were found in children with asthma, CF and PCD. The number of TGF-β1 positive cells correlated positively with the BM thickness in all groups. We suggest that this might be a common generic feature of bronchial remodelling in chronic respiratory diseases.

yes

### Human: The complex structural changes of bronchial mucosa, known as remodelling, have been considered unique and typical for asthma . The aim of this study was to compare basement membrane (BM) thickness and the number of transforming growth factor beta 1 (TGF-β1) positive epithelial cells in children with asthma, cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and healthy controls . A positive correlation was observed in all groups including controls . There was no difference in these parameters between asthma, CF and PCD . Is epithelial basement membrane thickening related to TGF-Beta 1 expression in children with chronic respiratory diseases?### Assistant: Increased BM thickness and number of TGF-β1 positive epithelial cells were found in children with asthma, CF and PCD. The number of TGF-β1 positive cells correlated positively with the BM thickness in all groups. We suggest that this might be a common generic feature of bronchial remodelling in chronic respiratory diseases.

Increased BM thickness and number of TGF-β1 positive epithelial cells were found in children with asthma, CF and PCD .

Does a strong sense of coherence promote regular dental attendance in adults?

Regular dental attendance was more common among those with a stronger SOC . Gender, education, family income and marital status, but not age, were related with dental attendance . The associations between the SOC and dental attendance pattern were found to be significantly stronger among those having high- or middle level of education compared with those having a low education level . The study consisted of 4,263, 30- to 64-year-old dentate, adults. The study was conducted in a nationally representative sample .

A stronger SOC is associated with regular dental attendance. This raises the possibility of achieving long-term positive effects on dental attendance in adulthood, if the SOC could be strengthened during adolescence.

yes

### Human: Regular dental attendance was more common among those with a stronger SOC . Gender, education, family income and marital status, but not age, were related with dental attendance . The associations between the SOC and dental attendance pattern were found to be significantly stronger among those having high- or middle level of education compared with those having a low education level . The study consisted of 4,263, 30- to 64-year-old dentate, adults. The study was conducted in a nationally representative sample . Does a strong sense of coherence promote regular dental attendance in adults?### Assistant: A stronger SOC is associated with regular dental attendance. This raises the possibility of achieving long-term positive effects on dental attendance in adulthood, if the SOC could be strengthened during adolescence.

A stronger SOC is associated with regular dental attendance . This raises the possibility of achieving long-term positive effects on dental attendance in adulthood .

Does [ Ursodeoxycholic acid treatment shorten the course of cholestasis in two patients with benign recurrent intrahepatic cholestasis ]?

Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomalomal-crecessive or sporadic disorder . In both patients biliary tract disease was ruled out by endoscopic retrograde cholangiopancreatography . No significant abnormalities of the liver parenchyma were found on liver biopsy . Early treatment with ursodeoxycholic acid (UDCA) reduced the duration of the cholstasis episode compared with that of other episodes in which the patient had received other treatment or the treatment was late .

Consensus is lacking on the treatment of BRIC although several treatment have been used. UDCA could be effective in increasing bile acid secretion and in reducing serum bilirubin levels. In the two patients described, the initial dosage was 15 mg/kg/day, which was subsequently maintained at 6 mg/kg/day, which was subsequently maintained 6 mg/kg/day until biochemical parameters returned to normal. Nevertheless, larger studies are required to confirm that UDA shortens episodes of cholestasis in BRIC.

yes

### Human: Benign recurrent intrahepatic cholestasis (BRIC) is a rare autosomalomal-crecessive or sporadic disorder . In both patients biliary tract disease was ruled out by endoscopic retrograde cholangiopancreatography . No significant abnormalities of the liver parenchyma were found on liver biopsy . Early treatment with ursodeoxycholic acid (UDCA) reduced the duration of the cholstasis episode compared with that of other episodes in which the patient had received other treatment or the treatment was late . Does [ Ursodeoxycholic acid treatment shorten the course of cholestasis in two patients with benign recurrent intrahepatic cholestasis ]?### Assistant: Consensus is lacking on the treatment of BRIC although several treatment have been used. UDCA could be effective in increasing bile acid secretion and in reducing serum bilirubin levels. In the two patients described, the initial dosage was 15 mg/kg/day, which was subsequently maintained at 6 mg/kg/day, which was subsequently maintained 6 mg/kg/day until biochemical parameters returned to normal. Nevertheless, larger studies are required to confirm that UDA shortens episodes of cholestasis in BRIC.

UDCA could be effective in increasing bile acid secretion and reducing serum bilirubin levels . In the two patients described, the

Is increased expression of P-selectin on platelets a risk factor for silent cerebral infarction in patients with atrial fibrillation : role of nitric oxide?

Plasma NOx levels were significantly decreased and the levels of P-selectin on platelets and of neutrophil/platelet conjugates were significantly increased after the onset of AF in a canine model of AF . Increased levels of NOx and advanced age were associated with the number of foci of silent cerebral infarction in patients with AF . In vitro experiments demonstrated that the inhibition of NO synthesis increased the expression of Pselectin in platelets . Multiple regression analysis revealed that increased P-Selectin on . platelets was associated with increased P .selectin and advanced . age were . associated with . the number . of focuses of silent .

An irregular heart rate that is characteristic of AF appeared to blunt NO synthesis. The increased expression of P-selectin on platelets associated with the reduced NO levels was a risk factor for silent cerebral infarction in patients with AF.

yes

### Human: Plasma NOx levels were significantly decreased and the levels of P-selectin on platelets and of neutrophil/platelet conjugates were significantly increased after the onset of AF in a canine model of AF . Increased levels of NOx and advanced age were associated with the number of foci of silent cerebral infarction in patients with AF . In vitro experiments demonstrated that the inhibition of NO synthesis increased the expression of Pselectin in platelets . Multiple regression analysis revealed that increased P-Selectin on . platelets was associated with increased P .selectin and advanced . age were . associated with . the number . of focuses of silent . Is increased expression of P-selectin on platelets a risk factor for silent cerebral infarction in patients with atrial fibrillation : role of nitric oxide?### Assistant: An irregular heart rate that is characteristic of AF appeared to blunt NO synthesis. The increased expression of P-selectin on platelets associated with the reduced NO levels was a risk factor for silent cerebral infarction in patients with AF.

An irregular heart rate that is characteristic of AF appeared to blunt NO synthesis . Increased expression of P-selectin on platelets associated with

Is triple negative breast cancer associated with an increased risk of residual invasive carcinoma after lumpectomy?

A review of pathologic specimens was performed for women with invasive breast cancer treated with lumpectomy followed by reexcision . Data were collected on 369 patients with breast cancer . The median age was 57 years, median tumor size was 1.5 cm, median . Median tumor size, grade, grade and nodal stage, margins; and reexcised findings . Overall, 32% of patients had invasive cancer in their reexcision specimens . 51% of those with the TN subtype had residual invasive disease on reexcisecision compared with 30% to 31% for other subtypes .

TN subtype has a statistically significant association with an increased risk of residual tumor. This suggests the putative increase in the risk of local failure in TN patients may be related to increased residual tumor burden.

yes

### Human: A review of pathologic specimens was performed for women with invasive breast cancer treated with lumpectomy followed by reexcision . Data were collected on 369 patients with breast cancer . The median age was 57 years, median tumor size was 1.5 cm, median . Median tumor size, grade, grade and nodal stage, margins; and reexcised findings . Overall, 32% of patients had invasive cancer in their reexcision specimens . 51% of those with the TN subtype had residual invasive disease on reexcisecision compared with 30% to 31% for other subtypes . Is triple negative breast cancer associated with an increased risk of residual invasive carcinoma after lumpectomy?### Assistant: TN subtype has a statistically significant association with an increased risk of residual tumor. This suggests the putative increase in the risk of local failure in TN patients may be related to increased residual tumor burden.

TN subtype has a statistically significant association with an increased risk of residual tumor . This suggests the putative increase in the risk of local

Does blockade of substantia nigra dopamine D1 receptors reduce intravenous cocaine reward in rats?

Blockade of dopamine D1-type receptors in ventral tegmental area reduces the rewarding effects of intravenous cocaine . We explored the possibility that blockade of D1 receptors in the adjacent substantia nigra (SN) might have similar effects . Microinjections of SCH 23390 in the SN significantly increased rates of cocaine self-administration, while injections dorsal to SN had no significant effect on responding to the drug . We tested the hypothesis that blocking of dopamine receptors in SN reduces the effects of cocaine .

These data suggest that blockade of dendritically released DA in the SN reduces the rewarding effects of cocaine. These findings complement accumulating evidence that the rewarding effects of cocaine are not restricted to the drug's ability to elevate dopamine levels in the nucleus accumbens.

yes

### Human: Blockade of dopamine D1-type receptors in ventral tegmental area reduces the rewarding effects of intravenous cocaine . We explored the possibility that blockade of D1 receptors in the adjacent substantia nigra (SN) might have similar effects . Microinjections of SCH 23390 in the SN significantly increased rates of cocaine self-administration, while injections dorsal to SN had no significant effect on responding to the drug . We tested the hypothesis that blocking of dopamine receptors in SN reduces the effects of cocaine . Does blockade of substantia nigra dopamine D1 receptors reduce intravenous cocaine reward in rats?### Assistant: These data suggest that blockade of dendritically released DA in the SN reduces the rewarding effects of cocaine. These findings complement accumulating evidence that the rewarding effects of cocaine are not restricted to the drug's ability to elevate dopamine levels in the nucleus accumbens.

These findings complement accumulating evidence that the rewarding effects of cocaine are not restricted to the drug's ability to elevate dopamine levels in the nucleus acc

Is mean platelet volume on admission associated with further left ventricular functions in primary PTCA patients?

In ST elevation myocardial infarction patients, mean platelet volume (MPV) is associated with infarct related artery patency both before and after reperfusion . In anterior STEMI patients successfully treated with primary percutaneous coronary intervention (PCI) relationship between left ventricular (LV) function and MPV on admission is unknown . The relationship between MPV and left ventricentric function is unknown, but MPV is linked to the risk of re-rewarding .

In anterior STEMI patients treated with percutaneous coronary intervention, increased MPV on admission is associated with impairment in left ventricular systolic function.

yes

### Human: In ST elevation myocardial infarction patients, mean platelet volume (MPV) is associated with infarct related artery patency both before and after reperfusion . In anterior STEMI patients successfully treated with primary percutaneous coronary intervention (PCI) relationship between left ventricular (LV) function and MPV on admission is unknown . The relationship between MPV and left ventricentric function is unknown, but MPV is linked to the risk of re-rewarding . Is mean platelet volume on admission associated with further left ventricular functions in primary PTCA patients?### Assistant: In anterior STEMI patients treated with percutaneous coronary intervention, increased MPV on admission is associated with impairment in left ventricular systolic function.

Increased MPV on admission is associated with impairment in left ventricular systolic function .

Does postoperative Regimentation Of Treatment optimize Care and Optimizes Length of Stay ( PROTOCOL ) after pyloromyotomy?

A non-standardized approach to caring for infants after pyloromyotomy for pyloric stenosis was associated with prolonged postoperative length of stay (pLOS) at our institution . We studied the impact of a standardized postoperative care protocol on pLOS, patients' clinical course, and nursing care . Protocol implementation resulted in fewer patients with prolonged pLOS and shorter time to feeds, fewer feeds to discharge, less emesis, and improved nursing documentation, we found . Protocols resulted in shorter time-to-feeds, fewer feeds to discharge and less emeses .

Implementation of a postoperative care protocol improved various aspects of patient care and nursing care studied. Protocols outline a patient's course and serve as a common platform for communication among care providers; they can facilitate, expedite, and enhance patient care.

yes

### Human: A non-standardized approach to caring for infants after pyloromyotomy for pyloric stenosis was associated with prolonged postoperative length of stay (pLOS) at our institution . We studied the impact of a standardized postoperative care protocol on pLOS, patients' clinical course, and nursing care . Protocol implementation resulted in fewer patients with prolonged pLOS and shorter time to feeds, fewer feeds to discharge, less emesis, and improved nursing documentation, we found . Protocols resulted in shorter time-to-feeds, fewer feeds to discharge and less emeses . Does postoperative Regimentation Of Treatment optimize Care and Optimizes Length of Stay ( PROTOCOL ) after pyloromyotomy?### Assistant: Implementation of a postoperative care protocol improved various aspects of patient care and nursing care studied. Protocols outline a patient's course and serve as a common platform for communication among care providers; they can facilitate, expedite, and enhance patient care.

Protocols outline a patient's course and serve as a common platform for communication among care providers . Protocols can facilitate, expedite,

Is the IL-17F signaling pathway involved in the induction of IFN-gamma-inducible protein 10 in bronchial epithelial cells?

Interferon-gamma-inducible protein 10 (IP-10) is widely expressed and plays a role in airway inflammatory diseases . IL-17F induces the gene and protein expression of IP-10 . The mitogen-activated protein kinase kinase . kinase (MEK) inhibitors PD98059, U0126, and Raf1 kinase inhibitor I significantly inhibited its production . In contrast, a p38 inhibitor, a JNK . inhibitor, JNK inhibitor, protein kinases C and phosphatidylinositol 3-kinase inhibitor, showed no inhibitory effect .

IL-17F is a potent inducer of IP-10 in bronchial epithelial cells through the activation of the Raf1-MEK1/2-extracellular signal-regulated kinase 1/2-p90RSK-CREB pathway, supporting its regulatory role in airway inflammation.

yes

### Human: Interferon-gamma-inducible protein 10 (IP-10) is widely expressed and plays a role in airway inflammatory diseases . IL-17F induces the gene and protein expression of IP-10 . The mitogen-activated protein kinase kinase . kinase (MEK) inhibitors PD98059, U0126, and Raf1 kinase inhibitor I significantly inhibited its production . In contrast, a p38 inhibitor, a JNK . inhibitor, JNK inhibitor, protein kinases C and phosphatidylinositol 3-kinase inhibitor, showed no inhibitory effect . Is the IL-17F signaling pathway involved in the induction of IFN-gamma-inducible protein 10 in bronchial epithelial cells?### Assistant: IL-17F is a potent inducer of IP-10 in bronchial epithelial cells through the activation of the Raf1-MEK1/2-extracellular signal-regulated kinase 1/2-p90RSK-CREB pathway, supporting its regulatory role in airway inflammation.

IL-17F is a potent inducer of IP-10 in bronchial epithelial cells . It supports its regulatory role in

Do liver stiffness-spleen size-to-platelet ratio risk score identifies esophageal varices in Japanese patients with chronic hepatitis C?

Non-invasive methods are needed to identify esophageal varices (EV) in patients with chronic liver disease . We evaluated liver stiffness (LS)-spleen diameter-to-platelet ratio risk score (LSPS) in predicting EV among Japanese chronic hepatitis C patients . LSPS was significantly correlated to the grade of EV and was superior to the other non-invasual indices for determination of EV. LSPS is independently associated with EV by multivariate logistic regression analysis .

LSPS may also identify EV in patients with chronic hepatitis C in Japan. The clinical values of LSPS for EV risk merit further validation in larger prospective studies.

yes

### Human: Non-invasive methods are needed to identify esophageal varices (EV) in patients with chronic liver disease . We evaluated liver stiffness (LS)-spleen diameter-to-platelet ratio risk score (LSPS) in predicting EV among Japanese chronic hepatitis C patients . LSPS was significantly correlated to the grade of EV and was superior to the other non-invasual indices for determination of EV. LSPS is independently associated with EV by multivariate logistic regression analysis . Do liver stiffness-spleen size-to-platelet ratio risk score identifies esophageal varices in Japanese patients with chronic hepatitis C?### Assistant: LSPS may also identify EV in patients with chronic hepatitis C in Japan. The clinical values of LSPS for EV risk merit further validation in larger prospective studies.

LSPS may also identify EV in patients with chronic hepatitis C in Japan . LSPS has been used in Japan to identify EV risk in

Is routine use of intravascular ultrasound for endovascular aneurysm repair : angiography necessary?

80 consecutive patients underwent endovascular aortic aneurysm repair (AAA 68 (85%), TAA 12 (15%) using either angiography in 31/80 patients (39%) or IVUS in 49/80 . Hospital mortality was 2/80 (3%), 1/68 for AAA (2%), 1-12 for TAA (8%), 2/31 for angiogram (7%) for IVUS (7%), and 0/49 for IVU (0.0%) Conversion to open surgery was necessary in 4/80 patient (5%), 3/49 patients (6%) and 6/9 patients for IVus (6%: NS)

IVUS is a reliable tool for EVAR. In most cases, perprocedural angiography is not necessary.

no

### Human: 80 consecutive patients underwent endovascular aortic aneurysm repair (AAA 68 (85%), TAA 12 (15%) using either angiography in 31/80 patients (39%) or IVUS in 49/80 . Hospital mortality was 2/80 (3%), 1/68 for AAA (2%), 1-12 for TAA (8%), 2/31 for angiogram (7%) for IVUS (7%), and 0/49 for IVU (0.0%) Conversion to open surgery was necessary in 4/80 patient (5%), 3/49 patients (6%) and 6/9 patients for IVus (6%: NS) Is routine use of intravascular ultrasound for endovascular aneurysm repair : angiography necessary?### Assistant: IVUS is a reliable tool for EVAR. In most cases, perprocedural angiography is not necessary.

IVUS is a reliable tool for EVAR . In most cases, perprocedural angiography is not necessary .

Does children 's auditory-perceptual performance in identifying phonological contrast among stops?

59 children (30 male and 29 female) were tested in a task of identification of occlusive consonants in Brazilian Portuguese . It was found an 85% auditory-perceptual accuracy and a positive correlation with age . According to the confusion matrix, perceptual difficulty of contrasts varied . voicing cues are more salient than articulation cues . For the variable place of articulation, it was observed an auditory-Perceptual asymmetry, in which the phonetic distance plays a key role in perceptual salience .

The auditory-perceptual ability regarding the identification of stop contrasts is still not stabilized in the age range studied. The auditory-perceptual mastery of occlusive contrasts occurs gradually and, within this class, there seems to be a hierarchy in mastery.

yes

### Human: 59 children (30 male and 29 female) were tested in a task of identification of occlusive consonants in Brazilian Portuguese . It was found an 85% auditory-perceptual accuracy and a positive correlation with age . According to the confusion matrix, perceptual difficulty of contrasts varied . voicing cues are more salient than articulation cues . For the variable place of articulation, it was observed an auditory-Perceptual asymmetry, in which the phonetic distance plays a key role in perceptual salience . Does children 's auditory-perceptual performance in identifying phonological contrast among stops?### Assistant: The auditory-perceptual ability regarding the identification of stop contrasts is still not stabilized in the age range studied. The auditory-perceptual mastery of occlusive contrasts occurs gradually and, within this class, there seems to be a hierarchy in mastery.

The auditory-perceptual ability regarding the identification of stop contrasts is still not stabilized in the age range studied . There seems to be

Does eGFR tyrosine kinase inhibition worsen acute lung injury in mice with repairing airway epithelium?

EGFR-tyrosine kinase inhibitor gefitinib is effective against advanced non-small cell lung cancer with EGFR mutations . Some patients treated with this agent develop severe acute interstitial pneumonia . Study found 17 genes with more than a threefold increase in bronchiolar epithelial cells from mice treated with 200 mg/kg after naphthalene at Day 14 compared with those treated with naphalene alone . Up-regulated genes included S100A8, S100 A6, S200A6, and StefinA3 .

EGFR inhibition in repairing airway epithelial cells modulated significant expression of genes involved in the airway microenvironment, prolonged inflammation, and potentiated acute lung injury.

yes

### Human: EGFR-tyrosine kinase inhibitor gefitinib is effective against advanced non-small cell lung cancer with EGFR mutations . Some patients treated with this agent develop severe acute interstitial pneumonia . Study found 17 genes with more than a threefold increase in bronchiolar epithelial cells from mice treated with 200 mg/kg after naphthalene at Day 14 compared with those treated with naphalene alone . Up-regulated genes included S100A8, S100 A6, S200A6, and StefinA3 . Does eGFR tyrosine kinase inhibition worsen acute lung injury in mice with repairing airway epithelium?### Assistant: EGFR inhibition in repairing airway epithelial cells modulated significant expression of genes involved in the airway microenvironment, prolonged inflammation, and potentiated acute lung injury.

EGFR inhibition in repairing airway epithelial cells modulated significant expression of genes involved in the airway microenvironment, prolonged inflammation,

Do psychoacoustic dynamic range and cochlear implant speech-perception performance in nucleus 22 users?

Some patients show wider electrical dynamic ranges than others and most have good speech perception performance . The knowledge of the average psycho-acoustical dynamic range in adults will help the audiologist program children who do not give reliable responses . Results showed that both dynamic ranges were wide in the two groups (average 50 units)Results showed that . Both dynamic ranges are wide in two groups of people with good speech-perception and patients with poor speech-Perception performances . Results were published in the Journal of Neurology .

Although dynamic ranges vary among subjects and electrodes, a lower variability was observed within the group of patients with better speech perception.

yes

### Human: Some patients show wider electrical dynamic ranges than others and most have good speech perception performance . The knowledge of the average psycho-acoustical dynamic range in adults will help the audiologist program children who do not give reliable responses . Results showed that both dynamic ranges were wide in the two groups (average 50 units)Results showed that . Both dynamic ranges are wide in two groups of people with good speech-perception and patients with poor speech-Perception performances . Results were published in the Journal of Neurology . Do psychoacoustic dynamic range and cochlear implant speech-perception performance in nucleus 22 users?### Assistant: Although dynamic ranges vary among subjects and electrodes, a lower variability was observed within the group of patients with better speech perception.

Dynamic ranges vary among subjects and electrodes, but a lower variability was observed within the group of patients with better speech perception .

Does laser fluorescence device perform well in detection of early caries lesions in primary teeth : an in vitro study?

A total of 181 occlusal sites in primary teeth were assessed by one examiner using DIAGNOdent . The same examiner and a second examiner evaluated 72 of the sites again to assess intra- and inter-examiner reproducibility . The overall LF performance was better at dentine threshold than at enamel threshold . The higher specificity was found at D3 and D2, and higher accuracy at D 3 (P < 0.001) The intra-and-examination agreements were classified as good or excellent for all thresholds .

The LF device performs better at the dentine threshold than at the enamel threshold. This method does not perform well in detecting initial enamel caries lesions.

no

### Human: A total of 181 occlusal sites in primary teeth were assessed by one examiner using DIAGNOdent . The same examiner and a second examiner evaluated 72 of the sites again to assess intra- and inter-examiner reproducibility . The overall LF performance was better at dentine threshold than at enamel threshold . The higher specificity was found at D3 and D2, and higher accuracy at D 3 (P < 0.001) The intra-and-examination agreements were classified as good or excellent for all thresholds . Does laser fluorescence device perform well in detection of early caries lesions in primary teeth : an in vitro study?### Assistant: The LF device performs better at the dentine threshold than at the enamel threshold. This method does not perform well in detecting initial enamel caries lesions.

Device performs better at the dentine threshold than at the enamel threshold . This method does not perform well in detecting initial enamel car

Does gliclazide protect human islet beta-cells from apoptosis induced by intermittent high glucose?

Chronic exposure to high glucose levels is a probable underlying mechanism, whereas the role of oral anti-diabetic agents (sulphonylureas in particular) is still unsettled . Gliclazide, but not glibenclamide, was able to significantly reduce high glucose induced apoptosis, mitochondrial alterations, and nitrotyrosine concentration increase . Apoptosis was also significantly increased by alternating high glucose exposure, which was accompanied by altered mitochondria morphology and density volume .

Therefore, gliclazide protected human beta-cells from apoptosis induced by intermittent high glucose, and this effect was likely to be due, at least in part, to the anti-oxidant properties of the molecule.

yes

### Human: Chronic exposure to high glucose levels is a probable underlying mechanism, whereas the role of oral anti-diabetic agents (sulphonylureas in particular) is still unsettled . Gliclazide, but not glibenclamide, was able to significantly reduce high glucose induced apoptosis, mitochondrial alterations, and nitrotyrosine concentration increase . Apoptosis was also significantly increased by alternating high glucose exposure, which was accompanied by altered mitochondria morphology and density volume . Does gliclazide protect human islet beta-cells from apoptosis induced by intermittent high glucose?### Assistant: Therefore, gliclazide protected human beta-cells from apoptosis induced by intermittent high glucose, and this effect was likely to be due, at least in part, to the anti-oxidant properties of the molecule.

Gliclazide protected human beta-cells from apoptosis induced by intermittent high glucose . This effect was likely to be due,

Does reduction of errors during practice facilitate fundamental movement skill learning in children with intellectual disabilities?

Children with intellectual disabilities (ID) have inferior motor proficiencies in fundamental movement skills (FMS) Study examined effects of training the FMS of overhand throwing by manipulating the amount of practice errors . The ER programme improved movement form, and increased throwing activity during free play to a greater extent than the ES programme . ER learners were found to be capable of engaging in a secondary cognitive task while manifesting robust throwing accuracy performance. ER learners also found to engage in a second cognitive task .

The findings support the use of movement skills training programmes that constrain practice errors in children with ID, suggesting that such approach results in improved performance and heightened movement engagement in free play.

yes

### Human: Children with intellectual disabilities (ID) have inferior motor proficiencies in fundamental movement skills (FMS) Study examined effects of training the FMS of overhand throwing by manipulating the amount of practice errors . The ER programme improved movement form, and increased throwing activity during free play to a greater extent than the ES programme . ER learners were found to be capable of engaging in a secondary cognitive task while manifesting robust throwing accuracy performance. ER learners also found to engage in a second cognitive task . Does reduction of errors during practice facilitate fundamental movement skill learning in children with intellectual disabilities?### Assistant: The findings support the use of movement skills training programmes that constrain practice errors in children with ID, suggesting that such approach results in improved performance and heightened movement engagement in free play.

The findings support the use of movement skills training programmes that constrain practice errors in children with ID .

Does parenteral 17beta-estradiol decrease fasting blood glucose levels in non-obese mice with short-term ovariectomy?

Long-term estrogen treatment prevented obesity by exerting anorexigenic and metabolic actions in ovariectomized mice . The effect of short-term hormone treatment on glucose metabolism in mice with short term ovariectomy is not yet clear . But three 17beta-estradiol injections did not affect insulin sensitivity and components of the insulin signaling pathway in the liver and skeletal muscle . The study was to evaluate the effect of parenteral 17beta drug treatment on blood glucose levels in mice at 2 weeks .

short-term parenteral 17beta-estradiol treatment decreases the fasting blood glucose levels not via insulin sensitivity of the skeletal muscle in non-obese mice with short-term ovariectomy.

yes

### Human: Long-term estrogen treatment prevented obesity by exerting anorexigenic and metabolic actions in ovariectomized mice . The effect of short-term hormone treatment on glucose metabolism in mice with short term ovariectomy is not yet clear . But three 17beta-estradiol injections did not affect insulin sensitivity and components of the insulin signaling pathway in the liver and skeletal muscle . The study was to evaluate the effect of parenteral 17beta drug treatment on blood glucose levels in mice at 2 weeks . Does parenteral 17beta-estradiol decrease fasting blood glucose levels in non-obese mice with short-term ovariectomy?### Assistant: short-term parenteral 17beta-estradiol treatment decreases the fasting blood glucose levels not via insulin sensitivity of the skeletal muscle in non-obese mice with short-term ovariectomy.

Short-term parenteral 17beta-estradiol treatment decreases the fasting blood glucose levels not via insulin sensitivity of the skeletal

Are bony landmarks an adequate substitute for lymphangiography in defining pelvic lymph node location for the treatment of cervical cancer with radiotherapy?

The best nonsurgical method of defining lymph node anatomy in the pelvis remains the lymphangiogram (LAG) This study was designed to determine if bony landmarks could accurately substitute for LAG as a means of determining lymph node position for the purpose of pelvic RT treatment planning . Ten of 22 patients would have had inadequate nodal irradiation if their fields had been designed according to standard Gynecologic Oncology Group parameters . In all cases, these incompletely irradiated lymph nodes were from the lowest of the lateral external iliac group .

Great variability in pelvic lymph node location is demonstrated when LAG is used to directly visualize their location. Bony structures are inaccurate landmarks for pelvic lymph node position. The GOG standard pelvic fields are not consistently adequate to cover all lateral external iliac lymph nodes, although the clinical significance of this subgroup of lymph nodes is not known. At this time, LAG remains the ideal radiographic modality to define anatomic location of regional lymph nodes for pelvic RT treatment planning. The clinical importance of the most lateral group of external iliac lymph nodes in various stages of cervical cancer represents a potential area of future research.

no

### Human: The best nonsurgical method of defining lymph node anatomy in the pelvis remains the lymphangiogram (LAG) This study was designed to determine if bony landmarks could accurately substitute for LAG as a means of determining lymph node position for the purpose of pelvic RT treatment planning . Ten of 22 patients would have had inadequate nodal irradiation if their fields had been designed according to standard Gynecologic Oncology Group parameters . In all cases, these incompletely irradiated lymph nodes were from the lowest of the lateral external iliac group . Are bony landmarks an adequate substitute for lymphangiography in defining pelvic lymph node location for the treatment of cervical cancer with radiotherapy?### Assistant: Great variability in pelvic lymph node location is demonstrated when LAG is used to directly visualize their location. Bony structures are inaccurate landmarks for pelvic lymph node position. The GOG standard pelvic fields are not consistently adequate to cover all lateral external iliac lymph nodes, although the clinical significance of this subgroup of lymph nodes is not known. At this time, LAG remains the ideal radiographic modality to define anatomic location of regional lymph nodes for pelvic RT treatment planning. The clinical importance of the most lateral group of external iliac lymph nodes in various stages of cervical cancer represents a potential area of future research.

Great variability in pelvic lymph node location demonstrated when LAG is used to directly visualize their location . Bony structures are inaccurate landmarks for pelvic

Is plantar tissue thickness related to peak plantar pressure in the high-risk diabetic foot?

A total of 157 diabetic neuropathic patients (VPT >25 V) without either peripheral vascular or ulcer history were studied . Plantar foot pressure and plantar tissue thickness were measured at each metatarsal head . Subjects with callus had significantly reduced plantar . thickness at all MTHs except the first MTH and increased peak pressures at all . MTHS were significantly associated with plantar subcutaneous tissue thickness . BMI was significantly related to plantar. tissue thickness, but not to peak forefoot pressures .

This study confirms a strong inverse relationship between plantar tissue thickness and dynamic foot pressure measurements. Long-term follow-up of this patient population will confirm whether reduced plantar tissue thickness predicts the development of diabetic foot ulcers.

yes

### Human: A total of 157 diabetic neuropathic patients (VPT >25 V) without either peripheral vascular or ulcer history were studied . Plantar foot pressure and plantar tissue thickness were measured at each metatarsal head . Subjects with callus had significantly reduced plantar . thickness at all MTHs except the first MTH and increased peak pressures at all . MTHS were significantly associated with plantar subcutaneous tissue thickness . BMI was significantly related to plantar. tissue thickness, but not to peak forefoot pressures . Is plantar tissue thickness related to peak plantar pressure in the high-risk diabetic foot?### Assistant: This study confirms a strong inverse relationship between plantar tissue thickness and dynamic foot pressure measurements. Long-term follow-up of this patient population will confirm whether reduced plantar tissue thickness predicts the development of diabetic foot ulcers.

Long-term follow-up of this patient population will confirm whether reduced plantar tissue thickness predicts the development of diabetic foot ulcers .

Do local anesthetics modulate neuronal calcium signaling through multiple sites of action?

Local anesthetics (LAs) are known to inhibit voltage-dependent Na+ channels, as well as K+ and Ca2+ channels . This study was aimed to investigate the LA effects on depolarization and receptor-mediated intracellular Ca2+. It also examined the role of Na+ and K+ channels in the LA effect on the evoked [Ca2+](i) transients . Coapplication of LA and Na+/K+ channel blockers was used to evaluate the role .

Different and overlapping sites of action of LAs are involved in inhibiting the KCl- and carbachol-evoked [Ca2+](i) transients, including voltage-dependent Ca2+ channels, a site associated with the caffeine-sensitive Ca2+ store and a possible site associated with the IP(3)-sensitive Ca2+ store, and a site in the muscarinic pathway. K+ channels, but not Na+ channels, seem to modulate the evoked [Ca2+](i) transients, as well as the LA-effects on such responses.

yes

### Human: Local anesthetics (LAs) are known to inhibit voltage-dependent Na+ channels, as well as K+ and Ca2+ channels . This study was aimed to investigate the LA effects on depolarization and receptor-mediated intracellular Ca2+. It also examined the role of Na+ and K+ channels in the LA effect on the evoked [Ca2+](i) transients . Coapplication of LA and Na+/K+ channel blockers was used to evaluate the role . Do local anesthetics modulate neuronal calcium signaling through multiple sites of action?### Assistant: Different and overlapping sites of action of LAs are involved in inhibiting the KCl- and carbachol-evoked [Ca2+](i) transients, including voltage-dependent Ca2+ channels, a site associated with the caffeine-sensitive Ca2+ store and a possible site associated with the IP(3)-sensitive Ca2+ store, and a site in the muscarinic pathway. K+ channels, but not Na+ channels, seem to modulate the evoked [Ca2+](i) transients, as well as the LA-effects on such responses.

Different sites of action of LAs are involved in inhibiting the KCl- and carbachol-evoked [Ca2+

Does tamoxifen decrease the myofibroblast count in the healing bile duct tissue of pigs?

The aim of this study was to evaluate the effect of oral tamoxifen treatment on the number of myofibroblasts present during the healing process after experimental bile duct injury . The study was conducted in 16 pigs that were sacrificed after 30 days . The animals were sacrificed and the study group was given tamoxfen (20 mg/day) The study group received a significant reduction in immunostaining for alpha smooth muscle actin compared with the control group (0.1155 vs. 0.2021)

Tamoxifen reduced the expression of alpha smooth muscle actin in the healing tissue after bile duct injury, suggesting a decrease in myofibroblasts in the scarred area of the pig biliary tract. These data suggest that tamoxifen could be used in the prevention of biliary tract stenosis after bile duct surgeries.

yes

### Human: The aim of this study was to evaluate the effect of oral tamoxifen treatment on the number of myofibroblasts present during the healing process after experimental bile duct injury . The study was conducted in 16 pigs that were sacrificed after 30 days . The animals were sacrificed and the study group was given tamoxfen (20 mg/day) The study group received a significant reduction in immunostaining for alpha smooth muscle actin compared with the control group (0.1155 vs. 0.2021) Does tamoxifen decrease the myofibroblast count in the healing bile duct tissue of pigs?### Assistant: Tamoxifen reduced the expression of alpha smooth muscle actin in the healing tissue after bile duct injury, suggesting a decrease in myofibroblasts in the scarred area of the pig biliary tract. These data suggest that tamoxifen could be used in the prevention of biliary tract stenosis after bile duct surgeries.

Tamoxifen reduced the expression of alpha smooth muscle actin in the healing tissue after bile duct injury . Suggested a decrease

Is induction of thyroid papillary carcinoma cell proliferation by estrogen associated with an altered expression of Bcl-xL?

The mechanism by which sex hormones contribute to the development of thyroid carcinoma is not well understood at present . An increased risk has also been documented in women who have used estrogens for gynecologic reasons . The results showed that estradiol promotes cell proliferation when compared with cells treated with testosterone and untreated cells, and that the growth-promoting effect of Estradiol was attenuated by tamoxifen . The expression of Bcl-xL was markedly increased in a dose-dependent manner .

We conclude that estradiol promotes KAT5 cell proliferation and that the underlying mechanism may be associated with up-regulation of Bcl-xL expression. The data provide insight into the molecular mechanism underlying the epidemiologic data that shows a two- to threefold increased prevalence of thyroid carcinoma in women relative to men. From the therapeutic point of view, the finding that estradiol enhances anti-apoptotic signaling pathways may be significant in the search for novel prevention and treatment strategies of thyroid carcinomas.

yes

### Human: The mechanism by which sex hormones contribute to the development of thyroid carcinoma is not well understood at present . An increased risk has also been documented in women who have used estrogens for gynecologic reasons . The results showed that estradiol promotes cell proliferation when compared with cells treated with testosterone and untreated cells, and that the growth-promoting effect of Estradiol was attenuated by tamoxifen . The expression of Bcl-xL was markedly increased in a dose-dependent manner . Is induction of thyroid papillary carcinoma cell proliferation by estrogen associated with an altered expression of Bcl-xL?### Assistant: We conclude that estradiol promotes KAT5 cell proliferation and that the underlying mechanism may be associated with up-regulation of Bcl-xL expression. The data provide insight into the molecular mechanism underlying the epidemiologic data that shows a two- to threefold increased prevalence of thyroid carcinoma in women relative to men. From the therapeutic point of view, the finding that estradiol enhances anti-apoptotic signaling pathways may be significant in the search for novel prevention and treatment strategies of thyroid carcinomas.

Estradiol promotes KAT5 cell proliferation and the underlying mechanism may be associated with up-regulation of Bcl-xL expression

Does food viscosity influence caloric intake compensation and body weight in rats?

Rats consumed dietary supplements equated for caloric and nutritive content but differing in viscosity . Rats given a low-viscosity supplement daily gained significantly more weight over a 10-week period compared with rats given a high viscosity dietary supplement . This effect was not specific to one thickening agent . The effect of consuming a lower viscosities premeal was followed by significantly more caloric intake . This was not the same effect on the effect of a thickening agents . The study was published in the journal Nature Biologia .

The results of these experiments suggest that food viscosity may be an important determinant of short-term caloric intake and longer term body weight gain.

yes

### Human: Rats consumed dietary supplements equated for caloric and nutritive content but differing in viscosity . Rats given a low-viscosity supplement daily gained significantly more weight over a 10-week period compared with rats given a high viscosity dietary supplement . This effect was not specific to one thickening agent . The effect of consuming a lower viscosities premeal was followed by significantly more caloric intake . This was not the same effect on the effect of a thickening agents . The study was published in the journal Nature Biologia . Does food viscosity influence caloric intake compensation and body weight in rats?### Assistant: The results of these experiments suggest that food viscosity may be an important determinant of short-term caloric intake and longer term body weight gain.

The results of these experiments suggest that food viscosity may be an important determinant of short-term caloric intake and longer term body

Is thrombus burden associated with clinical outcome after intra-arterial therapy for acute ischemic stroke?

The aim of the study was to determine the impact of intra-arterial thrombus burden on intra .arterial treatment (IAT) and clinical outcome . The baseline median median median National Institutes of Health Stroke Scale score was higher in patients of grade 4 compared with grades 0 to 3 . Grade 4 thrombi required longer (median, range) times for IAT (113, 37 to 415 minutes vs 74, 22 to 215 minutes, respectively; P<0.001) and higher rates of mechanical clot disruption .

High thrombus grade as measured by the modified Thrombolysis in Myocardial Infarction criteria may be a risk factor that contributes to poor clinical outcome.

yes

### Human: The aim of the study was to determine the impact of intra-arterial thrombus burden on intra .arterial treatment (IAT) and clinical outcome . The baseline median median median National Institutes of Health Stroke Scale score was higher in patients of grade 4 compared with grades 0 to 3 . Grade 4 thrombi required longer (median, range) times for IAT (113, 37 to 415 minutes vs 74, 22 to 215 minutes, respectively; P<0.001) and higher rates of mechanical clot disruption . Is thrombus burden associated with clinical outcome after intra-arterial therapy for acute ischemic stroke?### Assistant: High thrombus grade as measured by the modified Thrombolysis in Myocardial Infarction criteria may be a risk factor that contributes to poor clinical outcome.

High thrombus grade as measured by the modified Thrombolysis in Myocardial Infarction criteria may be a risk

Is occupational allergic contact dermatitis more prevalent than irritant contact dermatitis : a 5-year study?

Irritant contact dermatitis is thought to be the leading cause of occupational skin disease in the United States . Nickel sulfate, glutaraldehyde, and thiuram mix were the most common allergens . Health care professionals, machinists, and construction workers accounted for nearly half of all patients with occupational skin diseases . Health professionals, construction workers and machinist accounted for half of patients with skin disease . Allergants were found to be frequent in the population seen at a Midwestern dermatologic referral clinic .

Patch tests with a wider array of allergens than those currently available in the United States are needed to prevent misdiagnosis of occupational contact dermatitis.

yes

### Human: Irritant contact dermatitis is thought to be the leading cause of occupational skin disease in the United States . Nickel sulfate, glutaraldehyde, and thiuram mix were the most common allergens . Health care professionals, machinists, and construction workers accounted for nearly half of all patients with occupational skin diseases . Health professionals, construction workers and machinist accounted for half of patients with skin disease . Allergants were found to be frequent in the population seen at a Midwestern dermatologic referral clinic . Is occupational allergic contact dermatitis more prevalent than irritant contact dermatitis : a 5-year study?### Assistant: Patch tests with a wider array of allergens than those currently available in the United States are needed to prevent misdiagnosis of occupational contact dermatitis.

Patch tests with a wider array of allergens are needed to prevent misdiagnosis of occupational contact dermatitis . Patch tests are needed in

Are higher platelet counts associated with metabolic syndrome independent of fatty liver diagnosis?

The severity of hepatic fibrosis caused by fatty liver reduces PC . Higher PC was correlated with MS using multivariate analysis, while fatty liver had the strongest association with MS . MS was correlated among all age groups in women and in men under 60 years of age . The association between PC and MS did not reach statistical difference in men older than 60 years old, however, according to the study . The study was conducted at Taipei Veterans General Hospital from 2002 to 2009 . The findings were published in the Journal of Medical Innovation .

There is a significant correlation between PC and MS, and the correlation exists independent of gender, age, and fatty liver. PC may act as a surrogate marker for MS, and physicians should be concerned with the presence of MS among patients with high PC.

yes

### Human: The severity of hepatic fibrosis caused by fatty liver reduces PC . Higher PC was correlated with MS using multivariate analysis, while fatty liver had the strongest association with MS . MS was correlated among all age groups in women and in men under 60 years of age . The association between PC and MS did not reach statistical difference in men older than 60 years old, however, according to the study . The study was conducted at Taipei Veterans General Hospital from 2002 to 2009 . The findings were published in the Journal of Medical Innovation . Are higher platelet counts associated with metabolic syndrome independent of fatty liver diagnosis?### Assistant: There is a significant correlation between PC and MS, and the correlation exists independent of gender, age, and fatty liver. PC may act as a surrogate marker for MS, and physicians should be concerned with the presence of MS among patients with high PC.

PC may act as a surrogate marker for MS, and physicians should be concerned with the presence of MS among patients with high PC .

Does contractile capability of the diaphragm assessed by ultrasonography predict nocturnal oxygen saturation in COPD?

Diaphragm function might be useful to predict nocturnal oxygen desaturation in COPD . Ultrasonography has been widely used for the assessment of the diaphragma . We aimed to investigate the relationship between the contractile capability of the . diaphradm assessed by ultrasonography and the noct . percutaneous arterial oxygen saturation (NSpOTwenty-eight male patients with COPD (age, 73 ± 7 years; forced expiratory volume in 1 s (FEV)

This study suggested a close relationship between the NSpO

yes

### Human: Diaphragm function might be useful to predict nocturnal oxygen desaturation in COPD . Ultrasonography has been widely used for the assessment of the diaphragma . We aimed to investigate the relationship between the contractile capability of the . diaphradm assessed by ultrasonography and the noct . percutaneous arterial oxygen saturation (NSpOTwenty-eight male patients with COPD (age, 73 ± 7 years; forced expiratory volume in 1 s (FEV) Does contractile capability of the diaphragm assessed by ultrasonography predict nocturnal oxygen saturation in COPD?### Assistant: This study suggested a close relationship between the NSpO

Study suggested a close relationship between the NSpO and the N.SpO .

Is preoperative pulmonary hypertension associated with postoperative left ventricular dysfunction in chronic organic mitral regurgitation : an echocardiographic and hemodynamic study?

Some degree of pulmonary hypertension (PHTN) is common in patients with chronic mitral regurgitation . The aim of this study was to determine whether preoperative PHTN is associated with postoperative left ventricular (LV) dysfunction . The study included 79 patients who were diagnosed with chronic organic mitral . regurgitated . mitral patients with preoperative pulmonary artery systolic pressure and LV end-systolic dimension were independent predictors of postoperative LV ejection fraction .

Preoperative PHTN is associated with postoperative LV dysfunction in patients with chronic organic mitral regurgitation undergoing mitral valve operation.

yes

### Human: Some degree of pulmonary hypertension (PHTN) is common in patients with chronic mitral regurgitation . The aim of this study was to determine whether preoperative PHTN is associated with postoperative left ventricular (LV) dysfunction . The study included 79 patients who were diagnosed with chronic organic mitral . regurgitated . mitral patients with preoperative pulmonary artery systolic pressure and LV end-systolic dimension were independent predictors of postoperative LV ejection fraction . Is preoperative pulmonary hypertension associated with postoperative left ventricular dysfunction in chronic organic mitral regurgitation : an echocardiographic and hemodynamic study?### Assistant: Preoperative PHTN is associated with postoperative LV dysfunction in patients with chronic organic mitral regurgitation undergoing mitral valve operation.

Preoperative PHTN is associated with postoperative LV dysfunction in patients with chronic organic mitral regurgitation undergoing mitral valve operation

Does computer use increase the risk of musculoskeletal disorders among newspaper office workers?

A total of 73% (218 of 298) of office workers at a newspaper in Mexico City were studied . Working conditions, computer use, and ergonomic and psychosocial factors were studied as independent variables . Risk of musculoskeletal disorders was greater among workers at the newspaper who used computers, those involved in editing work, and those who adopted uncomfortable positions . The modifying effect was observed only in the relationship between ergonomic factors and WMSD-B because among workers with control over work, the risk was reduced by the greater number of work breaks .

The findings of our study showed that PC use increased risk of developing musculoskeletal disorders (WMSD-H and WMSD-UE). Such an increase is mediated by ergonomic factors such as mouse use, remaining seated for prolonged periods, adoption of inadequate or uncomfortable postures, performing certain PC tasks, and psychosocial factors.

yes

### Human: A total of 73% (218 of 298) of office workers at a newspaper in Mexico City were studied . Working conditions, computer use, and ergonomic and psychosocial factors were studied as independent variables . Risk of musculoskeletal disorders was greater among workers at the newspaper who used computers, those involved in editing work, and those who adopted uncomfortable positions . The modifying effect was observed only in the relationship between ergonomic factors and WMSD-B because among workers with control over work, the risk was reduced by the greater number of work breaks . Does computer use increase the risk of musculoskeletal disorders among newspaper office workers?### Assistant: The findings of our study showed that PC use increased risk of developing musculoskeletal disorders (WMSD-H and WMSD-UE). Such an increase is mediated by ergonomic factors such as mouse use, remaining seated for prolonged periods, adoption of inadequate or uncomfortable postures, performing certain PC tasks, and psychosocial factors.

PC use increased risk of developing musculoskeletal disorders (WMSD-H and WMSD U-H) Such

Is alkaline hemolysis fragility dependent on cell shape : results from a morphology tracker?

The morphometric analysis of red blood cells is an important area of study and has been performed previously for fixed samples . We present a novel method for the analysis of morphologic changes of live erythrocytes as a function of time . We use this method to extract information on alkaline hemolysis fragility . The average CSF went through a first period of fast increase, corresponding to the conversion of discocytes to spherocytes under internal osmotic pressure, followed by another period of slow increase until the fast lysis event .

RBCs inflate at a rate proportional to their surface area, in agreement with a constant flux model, and lyse after attaining a spherical morphology. Spherical RBCs display increased alkaline hemolysis fragility (shorter lifetimes), providing an explanation for the increased osmotic fragility of RBCs from patients who have spherocytosis.

yes

### Human: The morphometric analysis of red blood cells is an important area of study and has been performed previously for fixed samples . We present a novel method for the analysis of morphologic changes of live erythrocytes as a function of time . We use this method to extract information on alkaline hemolysis fragility . The average CSF went through a first period of fast increase, corresponding to the conversion of discocytes to spherocytes under internal osmotic pressure, followed by another period of slow increase until the fast lysis event . Is alkaline hemolysis fragility dependent on cell shape : results from a morphology tracker?### Assistant: RBCs inflate at a rate proportional to their surface area, in agreement with a constant flux model, and lyse after attaining a spherical morphology. Spherical RBCs display increased alkaline hemolysis fragility (shorter lifetimes), providing an explanation for the increased osmotic fragility of RBCs from patients who have spherocytosis.

Spherical RBCs display increased alkaline hemolysis fragility (shorter lifetimes) RBC's osmotic frag

Is bone mineral density in post-menopausal female subjects associated with serum antioxidant carotenoids?

Study showed association of bone mineral density with serum carotenoids . Beta-cryptoxanthin and beta-carotene may provide benefits to bone health in post-menopausal female subjects . The findings suggest beta-cryptoxinanthin may provide health benefits to post-manopausal females . Carotenoid concentrations were weakly but positively correlated with the radial BMD . The study was conducted in Shizuoka Prefecture, Japan . It found that this association was not significant after adjusting for intakes of minerals and vitamins .

Antioxidant carotenoids, especially beta-cryptoxanthin, significantly but partly associate with the radial BMD in post-menopausal female subjects.

yes

### Human: Study showed association of bone mineral density with serum carotenoids . Beta-cryptoxanthin and beta-carotene may provide benefits to bone health in post-menopausal female subjects . The findings suggest beta-cryptoxinanthin may provide health benefits to post-manopausal females . Carotenoid concentrations were weakly but positively correlated with the radial BMD . The study was conducted in Shizuoka Prefecture, Japan . It found that this association was not significant after adjusting for intakes of minerals and vitamins . Is bone mineral density in post-menopausal female subjects associated with serum antioxidant carotenoids?### Assistant: Antioxidant carotenoids, especially beta-cryptoxanthin, significantly but partly associate with the radial BMD in post-menopausal female subjects.

Carotenoids, especially beta-cryptoxanthin, significantly but partly associate with the radial BMD in post-menopausal

Is identification of accessory spleens during laparoscopic splenectomy superior to preoperative computed tomography for detection of accessory spleens?

Missed accessory spleen (AcS) can cause recurrence of hematologic disease after splenectomy . The study was to determine whether detection of AcS is more accurate with preoperative CT scan or with exploration during laparoscopic splenectectomy . The most common diagnosis was idiopathic thrombocytopenic purpura in 29 patients (39%) followed by non-Hodgkin's lymphoma in 22 patients (29%) Sixteen AcSs were found during surgery in 15 patients (20%), and preoperatively CT scan identified 2 of these .

Exploratory laparoscopy during splenectomy is more accurate than preoperative imaging with CT scan for detection of AcS. Preoperative CT scan misses AcS frequently and should not be obtained for the purpose of its identification.

yes

### Human: Missed accessory spleen (AcS) can cause recurrence of hematologic disease after splenectomy . The study was to determine whether detection of AcS is more accurate with preoperative CT scan or with exploration during laparoscopic splenectectomy . The most common diagnosis was idiopathic thrombocytopenic purpura in 29 patients (39%) followed by non-Hodgkin's lymphoma in 22 patients (29%) Sixteen AcSs were found during surgery in 15 patients (20%), and preoperatively CT scan identified 2 of these . Is identification of accessory spleens during laparoscopic splenectomy superior to preoperative computed tomography for detection of accessory spleens?### Assistant: Exploratory laparoscopy during splenectomy is more accurate than preoperative imaging with CT scan for detection of AcS. Preoperative CT scan misses AcS frequently and should not be obtained for the purpose of its identification.

Laparoscopy during splenectomy is more accurate than preoperative imaging with CT scan for detection of AcS . Preoperative CT

Is episodes of ST-segment depression related to changes in ambulatory blood pressure and heart rate in intermittent claudication?

Ischaemic ST-segment depression detected with ambulatory electrocardiographic monitoring (AECG) in patients with intermittent claudication (IC) as well as to study ambulatory blood pressure (ABP) and the relation of ischaemic episodes to variations in ABP and heart rate . The majority of episodes (11 of 15) occurred between 6 and 12 a.m. During ST-depression episodes systolic and diastolic blood pressure and heart rates were higher than day mean values; 178+/-41 vs. 166+/-30 mmHg .

Silent myocardial ischemia occurred in about a third of patients with IC. Episodes of ischaemia were associated with an increased ABP and heart rate. Whether treatment of high blood pressure may reduce silent ischaemia and if this favourably influences outcome is a matter of further research.

yes

### Human: Ischaemic ST-segment depression detected with ambulatory electrocardiographic monitoring (AECG) in patients with intermittent claudication (IC) as well as to study ambulatory blood pressure (ABP) and the relation of ischaemic episodes to variations in ABP and heart rate . The majority of episodes (11 of 15) occurred between 6 and 12 a.m. During ST-depression episodes systolic and diastolic blood pressure and heart rates were higher than day mean values; 178+/-41 vs. 166+/-30 mmHg . Is episodes of ST-segment depression related to changes in ambulatory blood pressure and heart rate in intermittent claudication?### Assistant: Silent myocardial ischemia occurred in about a third of patients with IC. Episodes of ischaemia were associated with an increased ABP and heart rate. Whether treatment of high blood pressure may reduce silent ischaemia and if this favourably influences outcome is a matter of further research.

Episodes of ischaemia were associated with an increased ABP and heart rate . Treatment of high blood pressure may reduce silent ischa

Does achyranthes aspera ( Apamarg ) leaf extract inhibit human pancreatic tumor growth in athymic mice by apoptosis?

Achyranthes aspera (Family Amaranthacea) is used for cancer therapy by ayurvedic medical practitioners in India . The in vivo anti tumor activity of leaf extract (LE) was tested by intraperitoneal (IP) injections into mice harboring human pancreatic tumor subcutaneous xenograft . LE significantly induced caspase-3 mRNA (p<0.001) and suppressed expression of the pro survival kinase Akt-1 (p)

Taken together, these data suggest A. aspera to have potent anti cancer property.

yes

### Human: Achyranthes aspera (Family Amaranthacea) is used for cancer therapy by ayurvedic medical practitioners in India . The in vivo anti tumor activity of leaf extract (LE) was tested by intraperitoneal (IP) injections into mice harboring human pancreatic tumor subcutaneous xenograft . LE significantly induced caspase-3 mRNA (p<0.001) and suppressed expression of the pro survival kinase Akt-1 (p) Does achyranthes aspera ( Apamarg ) leaf extract inhibit human pancreatic tumor growth in athymic mice by apoptosis?### Assistant: Taken together, these data suggest A. aspera to have potent anti cancer property.

Taken together, these data suggest A. aspera to have potent anti cancer property .

Do growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice?

AHR to inhaled methacholine increased at 6 h, peaked at 48 h, and remained elevated for 14 days . IL-4 and IL-5 levels in bronchoalveolar lavage (BAL) fluid were increased at . 6 h and 24 h, but returned to baseline quickly. IL-13 levels increased up to 14 days, peaking at . 48 h . IL4 levels in BAL fluid were . detected at 12 h, . peaked at 24 h . and returned to . baseline by 72 h .

These data identify a temporal association between growth factor production and Th2 cytokine production and the kinetics of AHR. Growth factors may play important roles in the development of allergic airway inflammation and AHR even in the early stages of asthma, before remodeling is initiated.

yes

### Human: AHR to inhaled methacholine increased at 6 h, peaked at 48 h, and remained elevated for 14 days . IL-4 and IL-5 levels in bronchoalveolar lavage (BAL) fluid were increased at . 6 h and 24 h, but returned to baseline quickly. IL-13 levels increased up to 14 days, peaking at . 48 h . IL4 levels in BAL fluid were . detected at 12 h, . peaked at 24 h . and returned to . baseline by 72 h . Do growth factors temporally associate with airway responsiveness and inflammation in allergen-exposed mice?### Assistant: These data identify a temporal association between growth factor production and Th2 cytokine production and the kinetics of AHR. Growth factors may play important roles in the development of allergic airway inflammation and AHR even in the early stages of asthma, before remodeling is initiated.

Growth factors may play important roles in the development of allergic airway inflammation and AHR even in the early stages of asthma, before remod

Is androgen excess associated with the increased carotid intima-media thickness observed in young women with polycystic ovary syndrome?

Carotid intima-media thickness (CIMT) was evaluated as an early marker of atherosclerosis . CIMT correlated directly with serum total and free testosterone, androstenedione and dehydroepiandrosterone-sulfate levels and mean 24-h heart rate . No correlation was observed with the body mass index (BMI) and the mean 24h HR . In PCOS patients, the main determinants of CIMt were serum total testosterone or androsthenione concentrations, with no influence of ISI .

Compared with control women, PCOS patients present with an increased CIMT, independent of obesity and related directly to androgen excess; this suggests that hyperandrogenism is associated with atherosclerosis and cardiovascular risk in these women.

yes

### Human: Carotid intima-media thickness (CIMT) was evaluated as an early marker of atherosclerosis . CIMT correlated directly with serum total and free testosterone, androstenedione and dehydroepiandrosterone-sulfate levels and mean 24-h heart rate . No correlation was observed with the body mass index (BMI) and the mean 24h HR . In PCOS patients, the main determinants of CIMt were serum total testosterone or androsthenione concentrations, with no influence of ISI . Is androgen excess associated with the increased carotid intima-media thickness observed in young women with polycystic ovary syndrome?### Assistant: Compared with control women, PCOS patients present with an increased CIMT, independent of obesity and related directly to androgen excess; this suggests that hyperandrogenism is associated with atherosclerosis and cardiovascular risk in these women.

PCOS patients present with an increased CIMT independent of obesity and related directly to androgen excess . This suggests that hyperandrogen

Does unilateral amyloid-beta25-35 injection into the rat amygdala increase the expressions of aberrant tau phosphorylation kinases?

Alzheimer disease is characterized by the presence of extracellular plaques enriched in beta-amyloid peptides . The mechanism by which it results in the neurotoxicity is uncertain . The purpose of this study was to investigate whether it would prompt the progress of Alzheimer disease via enhancement of aberrant phosphorylated tau that results from its increased kinase gene expression . The number of AT8 and PHF-1 positive cells in the AD model group showed the numbers of AT 8 and PHf-1 .

Unilateral injection of Abeta(25-35) into the rat amygdala increases the generation of aberrant phosphorylated tau by increasing GSK-3beta and P(38)MAPK gene expression, that accelerates the process of Alzhemer's disease.

yes

### Human: Alzheimer disease is characterized by the presence of extracellular plaques enriched in beta-amyloid peptides . The mechanism by which it results in the neurotoxicity is uncertain . The purpose of this study was to investigate whether it would prompt the progress of Alzheimer disease via enhancement of aberrant phosphorylated tau that results from its increased kinase gene expression . The number of AT8 and PHF-1 positive cells in the AD model group showed the numbers of AT 8 and PHf-1 . Does unilateral amyloid-beta25-35 injection into the rat amygdala increase the expressions of aberrant tau phosphorylation kinases?### Assistant: Unilateral injection of Abeta(25-35) into the rat amygdala increases the generation of aberrant phosphorylated tau by increasing GSK-3beta and P(38)MAPK gene expression, that accelerates the process of Alzhemer's disease.

Unilateral injection of Abeta(25-35) into the rat amygdala increases the generation of aberrant phosphorylated tau .

Does diet-induced weight loss lead to a switch in gene regulatory network control in the rectal mucosa?

Weight loss may decrease risk of colorectal cancer in obese individuals, yet its effect in the colorecum is not well understood . We used integrative network modeling to estimate transcriptional regulatory network models from mRNA expression levels from rectal mucosa biopsies measured pre- and post-weight loss in 10 obese, pre-menopausal women . Network analysis also suggested a regulatory switch from NFΚB1 to MAX control of MYC post-weigh loss . These findings were not evident by gene expression analysis alone .

These network-based results expand upon standard gene expression analysis by providing evidence for a potential mechanistic alteration caused by weight loss.

yes

### Human: Weight loss may decrease risk of colorectal cancer in obese individuals, yet its effect in the colorecum is not well understood . We used integrative network modeling to estimate transcriptional regulatory network models from mRNA expression levels from rectal mucosa biopsies measured pre- and post-weight loss in 10 obese, pre-menopausal women . Network analysis also suggested a regulatory switch from NFΚB1 to MAX control of MYC post-weigh loss . These findings were not evident by gene expression analysis alone . Does diet-induced weight loss lead to a switch in gene regulatory network control in the rectal mucosa?### Assistant: These network-based results expand upon standard gene expression analysis by providing evidence for a potential mechanistic alteration caused by weight loss.

Network-based results expand upon standard gene expression analysis by providing evidence for a potential mechanistic alteration caused by weight loss .

Is staphylococcal tetracycline-MLSB resistance plasmid pSTE2 the product of an RSA-mediated in vivo recombination?

The 6913 bp plasmid pSTE2 from Staphylococcus lentus mediates inducible resistance to tetracyclines, macrolides and lincosamides . Plasmid was analysed for potential reading frames and structural features to gain insight into its development from potential ancestor plasmids . In vitro susceptibility testing was performed to confirm the resistance phenotype mediated by this plasmide . Analysis of the junctions of the pT181-like and the pPV141-like homologous parts in p STE2 suggested that plasmido pSTE 2 developed from pT179- and pP141-

Plasmid pSTE2 is the first completely sequenced plasmid from S. lentus and represents the product of an in vivo derived RSA-mediated recombination between two compatible plasmids.

yes

### Human: The 6913 bp plasmid pSTE2 from Staphylococcus lentus mediates inducible resistance to tetracyclines, macrolides and lincosamides . Plasmid was analysed for potential reading frames and structural features to gain insight into its development from potential ancestor plasmids . In vitro susceptibility testing was performed to confirm the resistance phenotype mediated by this plasmide . Analysis of the junctions of the pT181-like and the pPV141-like homologous parts in p STE2 suggested that plasmido pSTE 2 developed from pT179- and pP141- Is staphylococcal tetracycline-MLSB resistance plasmid pSTE2 the product of an RSA-mediated in vivo recombination?### Assistant: Plasmid pSTE2 is the first completely sequenced plasmid from S. lentus and represents the product of an in vivo derived RSA-mediated recombination between two compatible plasmids.

Plasmid pSTE2 is the first completely sequenced plasmid from S. lentus . It represents the product of an

Does severe hypovitaminosis D correlate with increased inflammatory markers in HIV infected patients?

A study was carried out in an unselected cohort of 263 HIV infected outpatients consulting during Spring 2010 . A significant and positive association was found between SHD and IL6 (p = 0.001), hsCRP, increased serum C-Telopeptides X (CTX) and Parathyroid Hormon (PTH) levels . In multivariate analysis, SHD deficiency correlated significantly with increased IL-6, high serum CTX levels, lower mean daily exposure to the sun, current or past smoking, hepatitis C, and functional status (falls)

SHD is frequent and correlates with inflammation in HIV infected patients. Since SHD is also associated with falls and increased bone catabolism, it may be of interest to take into account not only the type of antiretroviral therapy but also the residual inflammation on HAART in order to assess functional and bone risks. This finding also suggests that vitamin D supplementation may be beneficial in these HIV-infected patients.

yes

### Human: A study was carried out in an unselected cohort of 263 HIV infected outpatients consulting during Spring 2010 . A significant and positive association was found between SHD and IL6 (p = 0.001), hsCRP, increased serum C-Telopeptides X (CTX) and Parathyroid Hormon (PTH) levels . In multivariate analysis, SHD deficiency correlated significantly with increased IL-6, high serum CTX levels, lower mean daily exposure to the sun, current or past smoking, hepatitis C, and functional status (falls) Does severe hypovitaminosis D correlate with increased inflammatory markers in HIV infected patients?### Assistant: SHD is frequent and correlates with inflammation in HIV infected patients. Since SHD is also associated with falls and increased bone catabolism, it may be of interest to take into account not only the type of antiretroviral therapy but also the residual inflammation on HAART in order to assess functional and bone risks. This finding also suggests that vitamin D supplementation may be beneficial in these HIV-infected patients.

SHD is frequent and correlates with inflammation in HIV infected patients . Vitamin D supplementation may be beneficial in these HIV-infected patients .

Does infarct extent by MRI correlate with peak serum troponin level in the canine model?

Troponin I is used routinely as an adjunct to EKG for the diagnosis of myocardial infarction (MI) A correlation between marker level and infarct size has yet to be documented in vivo . We report findings from a chronic coronary artery ligation model in the canine (n = 12) in which peak Troponins I is related to infarCT size as determined by high-resolution cardiac magnetic resonance imaging . A linear relationship exists (r = 0.98, P < 0.0001) In addition, we observed a negative trend between Infarct extent, peak Tropinin I, and ejection fraction .

The findings of this study indicate that Troponin I and cardiac magnetic resonance imaging provide a more accurate estimation of infarct size than was previously reported using markers with less sensitivity and imaging modalities of lower spatial resolution and viability imaging capability.

yes

### Human: Troponin I is used routinely as an adjunct to EKG for the diagnosis of myocardial infarction (MI) A correlation between marker level and infarct size has yet to be documented in vivo . We report findings from a chronic coronary artery ligation model in the canine (n = 12) in which peak Troponins I is related to infarCT size as determined by high-resolution cardiac magnetic resonance imaging . A linear relationship exists (r = 0.98, P < 0.0001) In addition, we observed a negative trend between Infarct extent, peak Tropinin I, and ejection fraction . Does infarct extent by MRI correlate with peak serum troponin level in the canine model?### Assistant: The findings of this study indicate that Troponin I and cardiac magnetic resonance imaging provide a more accurate estimation of infarct size than was previously reported using markers with less sensitivity and imaging modalities of lower spatial resolution and viability imaging capability.

Troponin I and cardiac magnetic resonance imaging provide a more accurate estimation of infarct size than was previously reported .

Does hydrogen sulfide suppress outward rectifier potassium currents in human pluripotent stem cell-derived cardiomyocytes?

Hydrogen sulfide (H₂S) is a promising cardioprotective agent and a potential modulator of cardiac ion currents . Yet its cardiac effects on humans are poorly understood due to lack of functional cardiomyocytes . This study investigates electrophysiological responses of human pluripotent stem cells (hPSCs) derived cardiomocytes towards H⁂S . In a concentration-dependent manner, NaHS consistently altered the action potential properties including prolonging action potential duration (APD) and slowing down contracting rates of ventricular-and atrial-like cardiocyocytes derived from both hESCs .

This is the first demonstration of effects of H₂S on cardiac electrophysiology of human ventricular-like, atrial-like and nodal-like cardiomyocytes. It reaffirmed the inhibitory effect of H₂S on I(CaL) and revealed additional novel inhibitory effects on I(f), I(Ks) and I(Kr) currents in human cardiomyocytes.

yes

### Human: Hydrogen sulfide (H₂S) is a promising cardioprotective agent and a potential modulator of cardiac ion currents . Yet its cardiac effects on humans are poorly understood due to lack of functional cardiomyocytes . This study investigates electrophysiological responses of human pluripotent stem cells (hPSCs) derived cardiomocytes towards H⁂S . In a concentration-dependent manner, NaHS consistently altered the action potential properties including prolonging action potential duration (APD) and slowing down contracting rates of ventricular-and atrial-like cardiocyocytes derived from both hESCs . Does hydrogen sulfide suppress outward rectifier potassium currents in human pluripotent stem cell-derived cardiomyocytes?### Assistant: This is the first demonstration of effects of H₂S on cardiac electrophysiology of human ventricular-like, atrial-like and nodal-like cardiomyocytes. It reaffirmed the inhibitory effect of H₂S on I(CaL) and revealed additional novel inhibitory effects on I(f), I(Ks) and I(Kr) currents in human cardiomyocytes.

This is the first demonstration of effects of H₂S on cardiac electrophysiology of human ventricular-like, at

Is nitric oxide production higher in rat cardiac microvessel endothelial cells than ventricular cardiomyocytes in baseline and hypoxic conditions : a comparative study?

A lack of direct studies on cardiac microvessel endothelial cells (CMEC) and cardiomyocytes regarding relative cellular NO production is unknown . Baseline NO production in CMEC was sevenfold (cultured cells) and 26-fold (isolated cells) higher than in cardiomocytes . Basine NO production was 2.2 times greater in CM EC than in Cardiomyocyte . In Hypoxia, nonselective NOS and iNOS-specific inhibition attenuated NO production .

Using a novel approach, this study demonstrated that CMEC produce more baseline NO than cardiomyocytes, and that hypoxia activates NOS to increase NO production in both cell types. Baseline eNOS content was higher in CMEC than in cardiomyocytes, suggesting that differences in baseline NO production were eNOS-associated.

yes

### Human: A lack of direct studies on cardiac microvessel endothelial cells (CMEC) and cardiomyocytes regarding relative cellular NO production is unknown . Baseline NO production in CMEC was sevenfold (cultured cells) and 26-fold (isolated cells) higher than in cardiomocytes . Basine NO production was 2.2 times greater in CM EC than in Cardiomyocyte . In Hypoxia, nonselective NOS and iNOS-specific inhibition attenuated NO production . Is nitric oxide production higher in rat cardiac microvessel endothelial cells than ventricular cardiomyocytes in baseline and hypoxic conditions : a comparative study?### Assistant: Using a novel approach, this study demonstrated that CMEC produce more baseline NO than cardiomyocytes, and that hypoxia activates NOS to increase NO production in both cell types. Baseline eNOS content was higher in CMEC than in cardiomyocytes, suggesting that differences in baseline NO production were eNOS-associated.

CMEC produce more baseline NO than cardiomyocytes . Hypoxia activates NOS to increase NO production in both cell types .

Is asthma in Mexican school-age children associated with passive smoking or obesity?

Asthma, passive smoking and a background of allergic diseases were identified by means of a standardized questionnaire filled out by the parents of the participants . There was no significant association to be found with asthma in either passive smoking where one of the parents smoked or in obesity . On the other hand, the background of allergies in the mother showed statistically significant association with asthma, but not in the girls . Asthma prevalence was found to be 8.1%; obesity 19.9%; background of smoking in the father 6.7% and the mother 13.3% .

With the exception of the maternal background of allergy, neither obesity nor passive smoking are factors associated with asthma in Mexican children.

no

### Human: Asthma, passive smoking and a background of allergic diseases were identified by means of a standardized questionnaire filled out by the parents of the participants . There was no significant association to be found with asthma in either passive smoking where one of the parents smoked or in obesity . On the other hand, the background of allergies in the mother showed statistically significant association with asthma, but not in the girls . Asthma prevalence was found to be 8.1%; obesity 19.9%; background of smoking in the father 6.7% and the mother 13.3% . Is asthma in Mexican school-age children associated with passive smoking or obesity?### Assistant: With the exception of the maternal background of allergy, neither obesity nor passive smoking are factors associated with asthma in Mexican children.

Neither obesity nor passive smoking are factors associated with asthma in Mexican children .

Does simvastatin improve left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects?

Little is known about effects of hypercholesterolemia and statin treatment in rabbits with experimental MI . New Zealand White rabbits underwent permanent coronary artery ligation . Simvastatin (5 mg/kg/day) prevented deterioration of LV function associated with hypercholicolemia . Simvasastatin also attenuated the depression of left ventricular function in MI rabbits . Elevated serum cholesterol levels were only partially reduced by simvastin treatment . The study was published in the European Journal of Clinical Trials, published online on November 4, 2013 .

Hypercholesterolemia further impaired the depressed LV function in rabbits post-MI. Statin treatment reversed this effect, and conferred additional protection, as in normocholesterolemic animals. Our study suggests that anti-inflammatory and anti-oxidative effects of simvastatin substantially contribute to its beneficial effects on cardiac function after MI.

yes

### Human: Little is known about effects of hypercholesterolemia and statin treatment in rabbits with experimental MI . New Zealand White rabbits underwent permanent coronary artery ligation . Simvastatin (5 mg/kg/day) prevented deterioration of LV function associated with hypercholicolemia . Simvasastatin also attenuated the depression of left ventricular function in MI rabbits . Elevated serum cholesterol levels were only partially reduced by simvastin treatment . The study was published in the European Journal of Clinical Trials, published online on November 4, 2013 . Does simvastatin improve left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects?### Assistant: Hypercholesterolemia further impaired the depressed LV function in rabbits post-MI. Statin treatment reversed this effect, and conferred additional protection, as in normocholesterolemic animals. Our study suggests that anti-inflammatory and anti-oxidative effects of simvastatin substantially contribute to its beneficial effects on cardiac function after MI.

Hypercholesterolemia further impaired the depressed LV function in rabbits post-MI . Statin treatment reversed this effect, and conferred additional

Does the antioxidant LY231617 reduce global ischemic neuronal injury in rats?

Antioxidant LY231617 (2,6-bis(1,1-dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol hydrochloride) reduced CA1 damage by 75% (p < 0.03) in the first experiment and by 41% in the second experiment . Addition of 5 microM of LY241617 to primary hippocampal neuronal cultures antagonized the lethal effect of hydrogen peroxide . Iron-dependent lipid peroxidation was also inhibited in a dose-related fashion .

The significant reduction of ischemia-induced or hydrogen peroxide-induced neuronal damage and inhibition of lipid peroxidation by LY231617 observed in this study suggest that reactive oxygen intermediates play an important role in the events leading to neuronal death after global ischemia/reperfusion.

yes

### Human: Antioxidant LY231617 (2,6-bis(1,1-dimethylethyl)-4-[[(1-ethyl)amino]methyl]phenol hydrochloride) reduced CA1 damage by 75% (p < 0.03) in the first experiment and by 41% in the second experiment . Addition of 5 microM of LY241617 to primary hippocampal neuronal cultures antagonized the lethal effect of hydrogen peroxide . Iron-dependent lipid peroxidation was also inhibited in a dose-related fashion . Does the antioxidant LY231617 reduce global ischemic neuronal injury in rats?### Assistant: The significant reduction of ischemia-induced or hydrogen peroxide-induced neuronal damage and inhibition of lipid peroxidation by LY231617 observed in this study suggest that reactive oxygen intermediates play an important role in the events leading to neuronal death after global ischemia/reperfusion.

Reactive oxygen intermediates play an important role in the events leading to neuronal death after global ischemia/reperfusion .

Does interleukin-17A be Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome?

Interleukin-17A is a proinflammatory cytokine known to play a role in host defense and pathologic inflammation in murine models of lung injury . The relationship between interleukins-17a and inflammation in human lung injury is unknown . We found elevated interleokin-A was associated with higher Sequential Organ Failure Assessment scores (p < 0.05) In both acute respiratory distress syndrome 1 and acute respiratory . distress syndrome . 2, elevated levels of interlekin-18A were associated with high levels of neutrophils and total protein in bronchoalveolar .

Elevated circulating and alveolar levels of interleukin-17A are associated with increased percentage of alveolar neutrophils, alveolar permeability, and organ dysfunction in acute respiratory distress syndrome.

yes

### Human: Interleukin-17A is a proinflammatory cytokine known to play a role in host defense and pathologic inflammation in murine models of lung injury . The relationship between interleukins-17a and inflammation in human lung injury is unknown . We found elevated interleokin-A was associated with higher Sequential Organ Failure Assessment scores (p < 0.05) In both acute respiratory distress syndrome 1 and acute respiratory . distress syndrome . 2, elevated levels of interlekin-18A were associated with high levels of neutrophils and total protein in bronchoalveolar . Does interleukin-17A be Associated With Alveolar Inflammation and Poor Outcomes in Acute Respiratory Distress Syndrome?### Assistant: Elevated circulating and alveolar levels of interleukin-17A are associated with increased percentage of alveolar neutrophils, alveolar permeability, and organ dysfunction in acute respiratory distress syndrome.

Interleukin-17A is associated with increased percentage of alveolar neutrophils, alveolars neutrophil,

Is immediate affective motivation impaired in schizophrenia?

Three affective evaluations are particularly relevant: interest in the activity itself, the pleasure anticipated from the activity and 3) the excitement experienced while looking forward to the activity . In patients, there were significant negative correlations between anticipated pleasure, pretest excitement and depression scores, and between pretest interest and negative symptoms . No group differences were found for excitement . Although extant research suggests that these affective processes may be impaired in schizophrenia, it is not clear whether these impairments are mostly secondary to cognitive deficits .

In these experiments, immediate affective evaluations reported by participants with schizophrenia or schizoaffective disorder were greater or similar to controls'. This finding is consistent with recent affective research showing that experiences of pleasure are intact in schizophrenia. These results emphasize the need to disentangle affective from cognitive processes in order to better understand the complex impairments present in schizophrenia spectrum disorders.

no

### Human: Three affective evaluations are particularly relevant: interest in the activity itself, the pleasure anticipated from the activity and 3) the excitement experienced while looking forward to the activity . In patients, there were significant negative correlations between anticipated pleasure, pretest excitement and depression scores, and between pretest interest and negative symptoms . No group differences were found for excitement . Although extant research suggests that these affective processes may be impaired in schizophrenia, it is not clear whether these impairments are mostly secondary to cognitive deficits . Is immediate affective motivation impaired in schizophrenia?### Assistant: In these experiments, immediate affective evaluations reported by participants with schizophrenia or schizoaffective disorder were greater or similar to controls'. This finding is consistent with recent affective research showing that experiences of pleasure are intact in schizophrenia. These results emphasize the need to disentangle affective from cognitive processes in order to better understand the complex impairments present in schizophrenia spectrum disorders.

Experiences of pleasure are intact in schizophrenia, according to recent research . Results emphasize the need to disentangle affective from cognitive processes

Is ePC-K1 effective in lung preservation in an ex vivo rabbit lung perfusion model?

L-Ascorbic acid potassium salt (EPC-K1) is a phosphate diester of alpha-tocopherol and ascorbic acid . It has been reported that EPC-k1 inhibits lipid peroxidation and phospholipase A2 . We hypothesized that the addition of EPCK1 might enhance lung preservation and reduce the degree of posttransplantation lung dysfunction . After storage the left lung was reperfused with autologous blood and ventilated using a membrane oxygenator .

The administration of EPC-K1 in the flush and preservation solution helps enhance lung graft function and suppresses lipid peroxidation after reperfusion.

yes

### Human: L-Ascorbic acid potassium salt (EPC-K1) is a phosphate diester of alpha-tocopherol and ascorbic acid . It has been reported that EPC-k1 inhibits lipid peroxidation and phospholipase A2 . We hypothesized that the addition of EPCK1 might enhance lung preservation and reduce the degree of posttransplantation lung dysfunction . After storage the left lung was reperfused with autologous blood and ventilated using a membrane oxygenator . Is ePC-K1 effective in lung preservation in an ex vivo rabbit lung perfusion model?### Assistant: The administration of EPC-K1 in the flush and preservation solution helps enhance lung graft function and suppresses lipid peroxidation after reperfusion.

Administration of EPC-K1 in the flush and preservation solution helps enhance lung graft function and suppresses lipid peroxidation after reper

Does a targeted immunomic approach identify diagnostic antigens in the human pathogen Babesia microti?

Babesia microti is a protozoan parasite responsible for the majority of reported cases of human babesiosis . There is no Food and Drug Administration-approved screening method yet available . BmGPI12 was identified as the best biomarker of infection that provided high sensitivity and specificity when used in a microarray antibody assay . Blood screening could have an important impact on decreasing the health burden of B. microti infection, authors say . Back to Mail Online home . Back To the page you came from .

BmGPI12 alone or in combination with other BmGPI proteins is a promising candidate biomarker for detection of B. microti antibodies that might be useful in blood screening to prevent transfusion-transmitted babesiosis.

yes

### Human: Babesia microti is a protozoan parasite responsible for the majority of reported cases of human babesiosis . There is no Food and Drug Administration-approved screening method yet available . BmGPI12 was identified as the best biomarker of infection that provided high sensitivity and specificity when used in a microarray antibody assay . Blood screening could have an important impact on decreasing the health burden of B. microti infection, authors say . Back to Mail Online home . Back To the page you came from . Does a targeted immunomic approach identify diagnostic antigens in the human pathogen Babesia microti?### Assistant: BmGPI12 alone or in combination with other BmGPI proteins is a promising candidate biomarker for detection of B. microti antibodies that might be useful in blood screening to prevent transfusion-transmitted babesiosis.

BmGPI12 is a promising candidate biomarker for detection of B. microti antibodies . It might be useful in blood screening

Does suberoylanilide hydroxamic acid partly reverse resistance to paclitaxel in human ovarian cancer cell lines?

SAHA was studied in combination with paclitaxel in PTX-sensitive and PTX resistant human ovarian cancer cell lines . The expression of acetylated tubulin was dramatically increased by exposure to the combination of PTX and SAHA . The combined exposure to PTX resulted in a marked arrest in the G2/M phase of the cell cycle and in a significant increase in the percentage of apoptotic cells . These data paralleled the findings of an increased expression of HDAC6 in the presence of PTx .

The results of this study suggest the existence of a novel resistance mechanism based upon the upregulation of HDAC6 and that the histone deacetylase inhibitor SAHA holds promise to overcome PTX resistance in ovarian cancer cell lines.

yes

### Human: SAHA was studied in combination with paclitaxel in PTX-sensitive and PTX resistant human ovarian cancer cell lines . The expression of acetylated tubulin was dramatically increased by exposure to the combination of PTX and SAHA . The combined exposure to PTX resulted in a marked arrest in the G2/M phase of the cell cycle and in a significant increase in the percentage of apoptotic cells . These data paralleled the findings of an increased expression of HDAC6 in the presence of PTx . Does suberoylanilide hydroxamic acid partly reverse resistance to paclitaxel in human ovarian cancer cell lines?### Assistant: The results of this study suggest the existence of a novel resistance mechanism based upon the upregulation of HDAC6 and that the histone deacetylase inhibitor SAHA holds promise to overcome PTX resistance in ovarian cancer cell lines.

The histone deacetylase inhibitor SAHA holds promise to overcome PTX resistance in ovarian cancer cell lines .

Does in vivo cyclic compression cause cartilage degeneration and subchondral bone changes in mouse tibiae?

Mechanic loading environment in joints may have beneficial and detrimental effects on articular cartilage and subchondral bone . The severity of joint damage increased with longer duration of loading . In both age groups of mice, cartilage thickness decreased, and bone thickness increased in the posterior tibial plateau in response to the 9.0N load . Mice in both ages developed periarticular osteophytes at the tibium plateau in . response to loading, but no osteophyte formation occurred in adult mice subjected to 4.5N peak loading .

This noninvasive loading model permits dissection of temporal and topographic changes in cartilage and bone and will enable investigation of the efficacy of treatment interventions targeting joint biomechanics or biologic events that promote OA onset and progression.

yes

### Human: Mechanic loading environment in joints may have beneficial and detrimental effects on articular cartilage and subchondral bone . The severity of joint damage increased with longer duration of loading . In both age groups of mice, cartilage thickness decreased, and bone thickness increased in the posterior tibial plateau in response to the 9.0N load . Mice in both ages developed periarticular osteophytes at the tibium plateau in . response to loading, but no osteophyte formation occurred in adult mice subjected to 4.5N peak loading . Does in vivo cyclic compression cause cartilage degeneration and subchondral bone changes in mouse tibiae?### Assistant: This noninvasive loading model permits dissection of temporal and topographic changes in cartilage and bone and will enable investigation of the efficacy of treatment interventions targeting joint biomechanics or biologic events that promote OA onset and progression.

This noninvasive loading model permits dissection of temporal and topographic changes in cartilage and bone . It will enable investigation of the

Are starch and starch hydrolysates favorable carbon sources for bifidobacteria in the human gut?

Bifidobacteria are key commensals in human gut, and their abundance is associated with the health of their hosts . Although they are dominant in infant gut, their number becomes lower in adult gut . The changes of the diet are considered to be main reason for this difference . Starch is a highly fermentable substrate, and can exert beneficial effects by increasing bifodobacteria and/or being fermented to short chain fatty acids . Bifobacteiral genomes encoded more GH genes for degrading starch and starch hydrolysates .

Our results demonstrated that starch and starch hydrolysates were the most universal and favorable carbon sources for bifidobacteria. The low amount of these carbon sources in adult intestine was speculated to contribute to the low relative abundance of bifidobacteria.

yes

### Human: Bifidobacteria are key commensals in human gut, and their abundance is associated with the health of their hosts . Although they are dominant in infant gut, their number becomes lower in adult gut . The changes of the diet are considered to be main reason for this difference . Starch is a highly fermentable substrate, and can exert beneficial effects by increasing bifodobacteria and/or being fermented to short chain fatty acids . Bifobacteiral genomes encoded more GH genes for degrading starch and starch hydrolysates . Are starch and starch hydrolysates favorable carbon sources for bifidobacteria in the human gut?### Assistant: Our results demonstrated that starch and starch hydrolysates were the most universal and favorable carbon sources for bifidobacteria. The low amount of these carbon sources in adult intestine was speculated to contribute to the low relative abundance of bifidobacteria.

starch and starch hydrolysates were the most universal and favorable carbon sources for bifidobacteria . The low amount of these carbon

Does constitutively active HIF-1alpha improve perfusion and arterial remodeling in an endovascular model of limb ischemia?

AdCA5 or AdLacZ (6 x 10(8) pfu) was injected into male New Zealand White rabbits that were untreated or subjected to occlusion of the left superficial femoral artery by endovascular coils . AdCa5 increased the expression of HIF-1alpha, monocyte chemotactic protein-1, placental growth factor, platelet-derived growth factor B, stromal-derived factor 1alpha, and vascular endothelial growth factor (VEGF) mRNA .

In a model that resembles atherosclerotic obstruction of peripheral arteries in patients, the i.m. administration of AdCA5 promoted arteriogenic and angiogenic responses.

yes

### Human: AdCA5 or AdLacZ (6 x 10(8) pfu) was injected into male New Zealand White rabbits that were untreated or subjected to occlusion of the left superficial femoral artery by endovascular coils . AdCa5 increased the expression of HIF-1alpha, monocyte chemotactic protein-1, placental growth factor, platelet-derived growth factor B, stromal-derived factor 1alpha, and vascular endothelial growth factor (VEGF) mRNA . Does constitutively active HIF-1alpha improve perfusion and arterial remodeling in an endovascular model of limb ischemia?### Assistant: In a model that resembles atherosclerotic obstruction of peripheral arteries in patients, the i.m. administration of AdCA5 promoted arteriogenic and angiogenic responses.

AdCA5 promoted arteriogenic and angiogenic responses in a model that resembles atherosclerotic obstruction of peripheral arteries in patients

Is elevated plasma CXCL12α associated with a poorer prognosis in pulmonary arterial hypertension?

CXCL12 (SDF-1) plays an important pathogenic role in pulmonary hypertension (PH) The objective of this study was to establish whether circulating concentrations of CXCl12α were elevated in patients with PAH and related to mortality . CXcl12α concentrations were found to be associated with reduced survival in PAH groups compared to controls . In the largest subset by WHO functional class (Class 3, 65% of patients) elevated CXCC12α independently predicted (P<0.05) earlier death .

Our data show that elevated concentrations of circulating CXCL12α in PAH predicted poorer survival. Furthermore, elevated circulating CXCL12α was an independent risk factor for death that could potentially be included in a prognostic model and guide therapy.

yes

### Human: CXCL12 (SDF-1) plays an important pathogenic role in pulmonary hypertension (PH) The objective of this study was to establish whether circulating concentrations of CXCl12α were elevated in patients with PAH and related to mortality . CXcl12α concentrations were found to be associated with reduced survival in PAH groups compared to controls . In the largest subset by WHO functional class (Class 3, 65% of patients) elevated CXCC12α independently predicted (P<0.05) earlier death . Is elevated plasma CXCL12α associated with a poorer prognosis in pulmonary arterial hypertension?### Assistant: Our data show that elevated concentrations of circulating CXCL12α in PAH predicted poorer survival. Furthermore, elevated circulating CXCL12α was an independent risk factor for death that could potentially be included in a prognostic model and guide therapy.

Elevated circulating CXCL12α was an independent risk factor for death that could potentially be included in a prognostic model and

Does novel restriction factor RNA-associated early-stage anti-viral factor ( REAF ) inhibit human and simian immunodeficiency viruses?

We identified RNA-associated Early-stage Anti-viral Factor (REAF) using a whole genome siRNA screen for restriction factors to human immunodeficiency virus (HIV) We observed more than 50 fold rescue of HIV-1 infection, using a focus forming unit (FFU) assay, following knockdown of REAF by specific siRNA . REAF associates with viral nucleic acids and may act to prevent reverse transcription . When REAF is over-expressed in target cells less infected cells are detectable .

This report firmly places REAF alongside APOBECs and SAMHD1 as a potent inhibitor of HIV replication acting early in the replication cycle, just after cell entry. We propose that REAF is part of an anti-viral surveillance system destroying incoming retroviruses. This novel mechanism could apply to invasion of cells by any intracellular pathogen.

yes

### Human: We identified RNA-associated Early-stage Anti-viral Factor (REAF) using a whole genome siRNA screen for restriction factors to human immunodeficiency virus (HIV) We observed more than 50 fold rescue of HIV-1 infection, using a focus forming unit (FFU) assay, following knockdown of REAF by specific siRNA . REAF associates with viral nucleic acids and may act to prevent reverse transcription . When REAF is over-expressed in target cells less infected cells are detectable . Does novel restriction factor RNA-associated early-stage anti-viral factor ( REAF ) inhibit human and simian immunodeficiency viruses?### Assistant: This report firmly places REAF alongside APOBECs and SAMHD1 as a potent inhibitor of HIV replication acting early in the replication cycle, just after cell entry. We propose that REAF is part of an anti-viral surveillance system destroying incoming retroviruses. This novel mechanism could apply to invasion of cells by any intracellular pathogen.

This report firmly places REAF alongside APOBECs and SAMHD1 as a potent inhibitor of HIV replication acting early in the replication

Is anabolic and catabolic function of chondrocyte ex vivo reflected by the metabolic processing of type II collagen?

The aim of the present study was to investigate collagen metabolism after anabolic and catabolic stimulation of chondrocytes ex-vital cartilage . The study was conducted with insulin-like growth factor I (IGF-I) or a combination of tumor necrosis factor alpha (TNFalpha) and oncostatin M (OSM) Supernatants were assessed for changes in biochemical markers, N-terminal propeptide of type II (PIINP) collagen and fragments of C-telopeptide (CTX-II) collagen .

This study is the first to demonstrate that precursors and degradation products of type II collagen released into the supernatant can effectively reflect the anabolic and catabolic activities of stimulated cartilage explants.

yes

### Human: The aim of the present study was to investigate collagen metabolism after anabolic and catabolic stimulation of chondrocytes ex-vital cartilage . The study was conducted with insulin-like growth factor I (IGF-I) or a combination of tumor necrosis factor alpha (TNFalpha) and oncostatin M (OSM) Supernatants were assessed for changes in biochemical markers, N-terminal propeptide of type II (PIINP) collagen and fragments of C-telopeptide (CTX-II) collagen . Is anabolic and catabolic function of chondrocyte ex vivo reflected by the metabolic processing of type II collagen?### Assistant: This study is the first to demonstrate that precursors and degradation products of type II collagen released into the supernatant can effectively reflect the anabolic and catabolic activities of stimulated cartilage explants.

This study is the first to demonstrate that precursors and degradation products of type II collagen released into the supernatant can effectively reflect

Does severe left ventricular hypertrophy 1 year after transplant predict mortality in cardiac transplant recipients?

Left ventricular hypertrophy (LVH) is a known predictor of morbidity and mortality in patients with essential hypertension . LVH was common at 1 year after heart transplantation, present in 83% of heart transplant recipients . Heart transplant recipients with severe LVH had significantly decreased survival, as compared to patients with normal LVM and mild-moderate LVH (p = 0.03) After multivariate analysis adjusting for age, race, gender, pre-transplant hypertension and diabetes, severe LV H remained a strong, independent predictor of mortality .

LVH is common at 1 year after heart transplantation and is a strong, independent predictor of increased mortality. Hypertension before transplantation is an independent predictor of the presence of severe LVH at 1 year after heart transplantation.

yes

### Human: Left ventricular hypertrophy (LVH) is a known predictor of morbidity and mortality in patients with essential hypertension . LVH was common at 1 year after heart transplantation, present in 83% of heart transplant recipients . Heart transplant recipients with severe LVH had significantly decreased survival, as compared to patients with normal LVM and mild-moderate LVH (p = 0.03) After multivariate analysis adjusting for age, race, gender, pre-transplant hypertension and diabetes, severe LV H remained a strong, independent predictor of mortality . Does severe left ventricular hypertrophy 1 year after transplant predict mortality in cardiac transplant recipients?### Assistant: LVH is common at 1 year after heart transplantation and is a strong, independent predictor of increased mortality. Hypertension before transplantation is an independent predictor of the presence of severe LVH at 1 year after heart transplantation.

LVH is common at 1 year after heart transplantation and is a strong, independent predictor of increased mortality . Hypertension before transplant

Is lower esophageal sphincter relaxation impaired in older patients with dysphagia?

A retrospective case-control audit was performed on 19 patients aged 80 years (mean age 85 ± 0.7 year) who underwent a manometric study for dysphagia (2004-2009) Data were compared with 19 younger dysphagic patients (32 ± 1.7 years) No age-related differences were seen in esophageal body pressures or peristalsis duration . In older patients, LES nadir pressure was higher with liquids (RL: 2.3 .6 mmHg vs. 0.6 mm Hg) and solids (P < 0.01)

Basal LES pressure is elevated and swallow-induced relaxation impaired in elderly dysphagic patients. Its contribution to dysphagia and the effects of healthy ageing require further investigation.

yes

### Human: A retrospective case-control audit was performed on 19 patients aged 80 years (mean age 85 ± 0.7 year) who underwent a manometric study for dysphagia (2004-2009) Data were compared with 19 younger dysphagic patients (32 ± 1.7 years) No age-related differences were seen in esophageal body pressures or peristalsis duration . In older patients, LES nadir pressure was higher with liquids (RL: 2.3 .6 mmHg vs. 0.6 mm Hg) and solids (P < 0.01) Is lower esophageal sphincter relaxation impaired in older patients with dysphagia?### Assistant: Basal LES pressure is elevated and swallow-induced relaxation impaired in elderly dysphagic patients. Its contribution to dysphagia and the effects of healthy ageing require further investigation.

Basal LES pressure is elevated and swallow-induced relaxation impaired in elderly dysphagic patients . Its contribution to dysphagia and the

Are molecular subtypes of urothelial carcinoma defined by specific gene regulatory systems?

Study finds that PPARG/RXRA, FOXA1/GATA3 and HOXA/HOXB are differentially expressed in UC molecular subtypes . It also links PLK1-FOXM1 axis to rapidly proliferating Genomically Unstable and SCC-like subtypes of UC . Study concludes that gene signatures and regulatory systems defined in urothelial carcinoma operate in breast cancer in a subtype specific manner, suggesting similarities at the gene regulatory level of these two tumors .

At the gene regulatory level Urobasal, Genomically Unstable and SCC-like tumors represents three fundamentally different tumor types. Urobasal tumors maintain an apparent urothelial differentiation axis composed of PPARG/RXRA, FOXA1/GATA3 and anterior HOXA and HOXB genes. Genomically Unstable and SCC-like tumors differ from Urobasal tumors by a strong increase of proliferative activity through the PLK1-FOXM1 axis operating in both subtypes. However, whereas SCC-like tumors evade urothelial differentiation by a block in differentiation through strong downregulation of PPARG/RXRA, FOXA1/GATA3, our data indicates that Genomically Unstable tumors evade differentiation in a more dynamic manner.

yes

### Human: Study finds that PPARG/RXRA, FOXA1/GATA3 and HOXA/HOXB are differentially expressed in UC molecular subtypes . It also links PLK1-FOXM1 axis to rapidly proliferating Genomically Unstable and SCC-like subtypes of UC . Study concludes that gene signatures and regulatory systems defined in urothelial carcinoma operate in breast cancer in a subtype specific manner, suggesting similarities at the gene regulatory level of these two tumors . Are molecular subtypes of urothelial carcinoma defined by specific gene regulatory systems?### Assistant: At the gene regulatory level Urobasal, Genomically Unstable and SCC-like tumors represents three fundamentally different tumor types. Urobasal tumors maintain an apparent urothelial differentiation axis composed of PPARG/RXRA, FOXA1/GATA3 and anterior HOXA and HOXB genes. Genomically Unstable and SCC-like tumors differ from Urobasal tumors by a strong increase of proliferative activity through the PLK1-FOXM1 axis operating in both subtypes. However, whereas SCC-like tumors evade urothelial differentiation by a block in differentiation through strong downregulation of PPARG/RXRA, FOXA1/GATA3, our data indicates that Genomically Unstable tumors evade differentiation in a more dynamic manner.

Urobasal tumors maintain an apparent urothelial differentiation axis composed of PPARG/RXRA, FOXA1

Does expression profiling of adrenocortical neoplasms suggest a molecular signature of malignancy?

We studied 7 patients with adrenocortical carcinomas and 13 with adenomas . Transcriptional profiles were homogeneous among adenoma, while carcinomas were much more heterogeneous . Hierarchical clustering and self-organizing maps could separate carcinomas from adenomites . Among genes that were most significantly upregulated in carcinomas, were 2 ubiquitin-related genes (USP4 and UFD1L) and several insulinlike growth factors (IGF2)

Through the use of cDNA arrays, adrenocortical adenomas and carcinomas appear to be clearly distinguishable on the basis of their specific molecular signature. The biologic importance of the up- and downregulated genes is yet to be determined.

yes

### Human: We studied 7 patients with adrenocortical carcinomas and 13 with adenomas . Transcriptional profiles were homogeneous among adenoma, while carcinomas were much more heterogeneous . Hierarchical clustering and self-organizing maps could separate carcinomas from adenomites . Among genes that were most significantly upregulated in carcinomas, were 2 ubiquitin-related genes (USP4 and UFD1L) and several insulinlike growth factors (IGF2) Does expression profiling of adrenocortical neoplasms suggest a molecular signature of malignancy?### Assistant: Through the use of cDNA arrays, adrenocortical adenomas and carcinomas appear to be clearly distinguishable on the basis of their specific molecular signature. The biologic importance of the up- and downregulated genes is yet to be determined.

adrenocortical adenomas and carcinomas appear to be clearly distinguishable on the basis of their specific molecular signature . The bi

Do alterations in wall tension and shear stress modulate tyrosine kinase signaling and wall remodeling in experimental vein grafts?

Carotid interposition bypass grafting was performed with the reversed jugular vein in New Zealand white rabbits . The use of a bioprosthetic collagen tube reduced wall tension 1.7-fold and increased shear stress 4.8-fold (P <.01) without altering the flow rate or blood pressure . The intimal thickness was reduced by 45% in the tube-supported vein grafts as compared with the control grafts . Isometric tension studies showed preservation of contractile function and modulation of endothelial-dependent dysfunctional relaxation .

These results show that reduced wall tension and increased shear stress with an external tube support can effectively modulate the signaling, functional, and hyperplastic responses in vein grafts. We conclude that this simple strategy deserves further study and clinical consideration.

yes

### Human: Carotid interposition bypass grafting was performed with the reversed jugular vein in New Zealand white rabbits . The use of a bioprosthetic collagen tube reduced wall tension 1.7-fold and increased shear stress 4.8-fold (P <.01) without altering the flow rate or blood pressure . The intimal thickness was reduced by 45% in the tube-supported vein grafts as compared with the control grafts . Isometric tension studies showed preservation of contractile function and modulation of endothelial-dependent dysfunctional relaxation . Do alterations in wall tension and shear stress modulate tyrosine kinase signaling and wall remodeling in experimental vein grafts?### Assistant: These results show that reduced wall tension and increased shear stress with an external tube support can effectively modulate the signaling, functional, and hyperplastic responses in vein grafts. We conclude that this simple strategy deserves further study and clinical consideration.

An external tube support can effectively modulate the signaling, functional, and hyperplastic responses in vein grafts . We conclude that this

Does systemic FasL neutralization increase eosinophilic inflammation in a mouse model of asthma?

Eosinophils and lymphocytes are pathogenically important in allergic inflammation and sensitive to Fas-mediated apoptosis . Fas ligand (FasL) activity should play a role in regulating the allergic immune response . We aimed to characterize the role of FasL expression in airway eosinsophilia in Aspergillus fumigatus (Af)-induced sensitization and to determine whether FasL neutralization alters the inflammatory response . Systemic FasL . neutralization significantly enhanced BAL and tissue eosInophil counts .

FasL activity may play an active role in resolving eosinophilic inflammation through regulating T cells and pro-eosinophilic cytokine release during the allergic airway response.

yes

### Human: Eosinophils and lymphocytes are pathogenically important in allergic inflammation and sensitive to Fas-mediated apoptosis . Fas ligand (FasL) activity should play a role in regulating the allergic immune response . We aimed to characterize the role of FasL expression in airway eosinsophilia in Aspergillus fumigatus (Af)-induced sensitization and to determine whether FasL neutralization alters the inflammatory response . Systemic FasL . neutralization significantly enhanced BAL and tissue eosInophil counts . Does systemic FasL neutralization increase eosinophilic inflammation in a mouse model of asthma?### Assistant: FasL activity may play an active role in resolving eosinophilic inflammation through regulating T cells and pro-eosinophilic cytokine release during the allergic airway response.

FasL activity may play an active role in resolving eosinophilic inflammation . It regulates T cells and pro-eosin

Does inhibition of PI3K promote dilation of human small airways in a rho kinase-dependent manner?

Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness . Although the molecular mechanisms remain unclear, activation of specific PI3K isoforms mediate inflammation and AHR . We aimed to determine whether inhibition of PI3kδ evokes dilation of airways and to elucidate potential mechanisms . In the presence of IL-13, dilation by a β agonist, but not PI3 k inhibitor, was attenuated . After desensitization of the β2 -adrenoceptors, a PIKδ inhibitor remained an effective dilator .

PI3Kδ inhibitors act as dilators of human small airways. Taken together, these findings provide alternative approaches to the clinical management of airway obstruction in asthma.

yes

### Human: Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness . Although the molecular mechanisms remain unclear, activation of specific PI3K isoforms mediate inflammation and AHR . We aimed to determine whether inhibition of PI3kδ evokes dilation of airways and to elucidate potential mechanisms . In the presence of IL-13, dilation by a β agonist, but not PI3 k inhibitor, was attenuated . After desensitization of the β2 -adrenoceptors, a PIKδ inhibitor remained an effective dilator . Does inhibition of PI3K promote dilation of human small airways in a rho kinase-dependent manner?### Assistant: PI3Kδ inhibitors act as dilators of human small airways. Taken together, these findings provide alternative approaches to the clinical management of airway obstruction in asthma.

PI3Kδ inhibitors act as dilators of human small airways . Taken together, these findings provide alternative approaches to the clinical

Does the substance P receptor antagonist CP-99,994 reduce acute postoperative pain?

CP-99,994, a NK1 receptor antagonist, was compared with ibuprofen and placebo in 78 subjects undergoing third molar extraction . Animal studies suggest that substance P, a peptide that preferentially activates the neurokinin-1 (NK1) receptor, is involved in pain transmission, with particular importance in pain after inflammation . The incidence of side effects was similar across groups, with the incidence of the side effects being similar across the groups . In the first study, ibupofen significantly reduced pain, as measured by visual analog scale, compared with placebo .

This replicate demonstration that a NK1 receptor blocker relieves clinical pain supports the hypothesis that substance P contributes to the generation of pain in humans. The reduction in postoperative pain at doses not producing side effects suggests that NK1 antagonists may be clinically useful.

yes

### Human: CP-99,994, a NK1 receptor antagonist, was compared with ibuprofen and placebo in 78 subjects undergoing third molar extraction . Animal studies suggest that substance P, a peptide that preferentially activates the neurokinin-1 (NK1) receptor, is involved in pain transmission, with particular importance in pain after inflammation . The incidence of side effects was similar across groups, with the incidence of the side effects being similar across the groups . In the first study, ibupofen significantly reduced pain, as measured by visual analog scale, compared with placebo . Does the substance P receptor antagonist CP-99,994 reduce acute postoperative pain?### Assistant: This replicate demonstration that a NK1 receptor blocker relieves clinical pain supports the hypothesis that substance P contributes to the generation of pain in humans. The reduction in postoperative pain at doses not producing side effects suggests that NK1 antagonists may be clinically useful.

A replicate demonstration that a NK1 receptor blocker relieves clinical pain supports the hypothesis that substance P contributes to the generation of pain in humans

Is obstructive sleep apnea associated with fatty liver index , the index of nonalcoholic fatty liver disease?

The relationship between obstructive sleep apnea and nonalcoholic fatty liver disease (NAFLD) is gaining increased attention . The aim of the study was to examine the relationship of OSA with NAFLD defined by an elevated fatty liver index (FLI) An FLI of 60 achieved the highest diagnostic accuracy and yielded an area under the receiver operator characteristic curve of 0.822 (95% confidence interval: 0.729-0.916) in the detection of NAFLd .

Our results suggest a positive association between the severity of OSA and NAFLD defined by an elevated FLI, which may serve as a good biomarker for detecting NAFLD in OSA patients.

yes

### Human: The relationship between obstructive sleep apnea and nonalcoholic fatty liver disease (NAFLD) is gaining increased attention . The aim of the study was to examine the relationship of OSA with NAFLD defined by an elevated fatty liver index (FLI) An FLI of 60 achieved the highest diagnostic accuracy and yielded an area under the receiver operator characteristic curve of 0.822 (95% confidence interval: 0.729-0.916) in the detection of NAFLd . Is obstructive sleep apnea associated with fatty liver index , the index of nonalcoholic fatty liver disease?### Assistant: Our results suggest a positive association between the severity of OSA and NAFLD defined by an elevated FLI, which may serve as a good biomarker for detecting NAFLD in OSA patients.

An elevated FLI may serve as a good biomarker for detecting NAFLD in OSA patients .

Does prehypoxic clonidine administration improve vasomotricity of isolated rat aorta during reoxygenation?

Clonidine, an alpha-2 adrenoceptor (A2A) agonist, improves posthypoxic function of several organs in humans and animal models . Mechanisms underlying these effects are not fully understood . A competent vasomotricity during reperfusion participates in the organ's recovery . This study investigates the specific effect of clonidine administration before hypoxia on post hypoxic vasomomotricsity in a rodent model . In the presence of BRL44408, clonidine increases posthypoxoxic endothelial dysfunction (P = 0.001)

Clonidine improves posthypoxic vasomotricity on isolated aortic rings. Concerning PED, two endothelial A2A subtypes are required. The clonidine effect on posthypoxic contraction requires endothelial A2A. Nitrogen oxide does not seem to be involved. Concerning the clonidine effect on PED and posthypoxic contraction, cyclooxygenase metabolites seem to be involved.

yes

### Human: Clonidine, an alpha-2 adrenoceptor (A2A) agonist, improves posthypoxic function of several organs in humans and animal models . Mechanisms underlying these effects are not fully understood . A competent vasomotricity during reperfusion participates in the organ's recovery . This study investigates the specific effect of clonidine administration before hypoxia on post hypoxic vasomomotricsity in a rodent model . In the presence of BRL44408, clonidine increases posthypoxoxic endothelial dysfunction (P = 0.001) Does prehypoxic clonidine administration improve vasomotricity of isolated rat aorta during reoxygenation?### Assistant: Clonidine improves posthypoxic vasomotricity on isolated aortic rings. Concerning PED, two endothelial A2A subtypes are required. The clonidine effect on posthypoxic contraction requires endothelial A2A. Nitrogen oxide does not seem to be involved. Concerning the clonidine effect on PED and posthypoxic contraction, cyclooxygenase metabolites seem to be involved.

Clonidine improves posthypoxic vasomotricity on isolated aortic rings . Two endothelial A2A subtypes

Does pregestational maternal obesity impair endocrine pancreas in male F1 and F2 progeny?

The aim of this study was to evaluate the effects of maternal obesity on pancreas structure and carbohydrate metabolism in early adult life . F1-HF and F2-HF offspring showed hyperinsulinemia, hyperleptinemia and decreased adiponectin levels, increased pancreatic mass, and islet volume density with elevated α- and β-cell mass . The F1/F2/F1-F2-F1 offspring showed a weak pancreatic-duodenal homeobox (Pdx)1 immunoreactivity .

Maternal HF diet consumed during the preconception period and throughout the gestation and lactation periods in mice promotes metabolism and pancreatic programming in F1 and F2 male offspring, implying intergenerational effects.

yes

### Human: The aim of this study was to evaluate the effects of maternal obesity on pancreas structure and carbohydrate metabolism in early adult life . F1-HF and F2-HF offspring showed hyperinsulinemia, hyperleptinemia and decreased adiponectin levels, increased pancreatic mass, and islet volume density with elevated α- and β-cell mass . The F1/F2/F1-F2-F1 offspring showed a weak pancreatic-duodenal homeobox (Pdx)1 immunoreactivity . Does pregestational maternal obesity impair endocrine pancreas in male F1 and F2 progeny?### Assistant: Maternal HF diet consumed during the preconception period and throughout the gestation and lactation periods in mice promotes metabolism and pancreatic programming in F1 and F2 male offspring, implying intergenerational effects.

Maternal HF diet consumed during the preconception period and throughout the gestation and lactation periods in mice promotes metabolism and pancreatic programming in

Does tuberculosis retreatment category predict resistance in hospitalized retreatment patients in a high HIV prevalence area?

MDR-TB prevalence is known to be high in patients categorized as treatment failures . Treatment failure category predicted resistance, with 57.1% of patients exhibiting any resistance compared to other treatment categories . 53.8% of those with any resistance experienced poor outcomes, compared to 16.6% of pan-susceptible cases . There was a trend towards poor outcome in the treatment failure category (42.9%, P = 0.13). There was an in-hospital mortality (19.8%), or poor outcome (26.4%)

The retreatment category 'treatment failure' is associated with a high prevalence of resistance in an area of high human immunodeficiency virus (HIV) prevalence. The 'treatment failure' category should be used to identify patients who may benefit from alternative regimens using directed, intensified therapy or second-line agents instead of the current standard retreatment regimen.

yes

### Human: MDR-TB prevalence is known to be high in patients categorized as treatment failures . Treatment failure category predicted resistance, with 57.1% of patients exhibiting any resistance compared to other treatment categories . 53.8% of those with any resistance experienced poor outcomes, compared to 16.6% of pan-susceptible cases . There was a trend towards poor outcome in the treatment failure category (42.9%, P = 0.13). There was an in-hospital mortality (19.8%), or poor outcome (26.4%) Does tuberculosis retreatment category predict resistance in hospitalized retreatment patients in a high HIV prevalence area?### Assistant: The retreatment category 'treatment failure' is associated with a high prevalence of resistance in an area of high human immunodeficiency virus (HIV) prevalence. The 'treatment failure' category should be used to identify patients who may benefit from alternative regimens using directed, intensified therapy or second-line agents instead of the current standard retreatment regimen.

'treatment failure' is associated with a high prevalence of resistance in an area of high human immunodeficiency virus (HIV)

Is temporal horn enlargement present in schizophrenia and bipolar disorder?

Study compares quantitative measures of temporal lobe, hemispheric, and ventricular volumes in a group of patients with chronic schizophrenia and bipolar disorder . The study seeks to determine if the groups can be differentiated on the basis of measured brain abnormalities . The two patient groups did not differ from each other or controls on any other tissue or fluid measure . Both patient groups had significantly larger temporal horn volumes in comparison with the control group both before and after correction for intracranial volume . The authors conclude that this study is a useful tool for understanding schizophrenia and affective disorder .

This study confirms the findings of increased temporal horn volume in patients with schizophrenia and suggests that this structural abnormality does not differentiate the structural neuropathology of schizophrenia from that of bipolar disorder.

yes

### Human: Study compares quantitative measures of temporal lobe, hemispheric, and ventricular volumes in a group of patients with chronic schizophrenia and bipolar disorder . The study seeks to determine if the groups can be differentiated on the basis of measured brain abnormalities . The two patient groups did not differ from each other or controls on any other tissue or fluid measure . Both patient groups had significantly larger temporal horn volumes in comparison with the control group both before and after correction for intracranial volume . The authors conclude that this study is a useful tool for understanding schizophrenia and affective disorder . Is temporal horn enlargement present in schizophrenia and bipolar disorder?### Assistant: This study confirms the findings of increased temporal horn volume in patients with schizophrenia and suggests that this structural abnormality does not differentiate the structural neuropathology of schizophrenia from that of bipolar disorder.

This structural abnormality does not differentiate the structural neuropathology of schizophrenia from that of bipolar disorder .

Is low-risk HLA genotype in Type 1 diabetes associated with less destruction of pancreatic B-cells 12 months after diagnosis?

The role of human leukocyte antigen (HLA) genes in the susceptibility to Type 1 diabetes (T1DM) is well known . However, we do not know whether the degree of pancreatic B-cell destruction depends on different HLA genetic risk . The aim of this study was to analyse the influence of DRB1* and DQB1* genes on the rate of B-cells loss in a prospective series of 120 newly diagnosed T1DM subjects in the first 12 months after diagnosis .

Low-risk HLA genotype in T1DM is associated with less destruction of pancreatic B-cells up to 12 months after diagnosis. These results are useful when designing trials for therapies aimed to prevent the progression of B-cell destruction in recent-onset T1DM.

yes

### Human: The role of human leukocyte antigen (HLA) genes in the susceptibility to Type 1 diabetes (T1DM) is well known . However, we do not know whether the degree of pancreatic B-cell destruction depends on different HLA genetic risk . The aim of this study was to analyse the influence of DRB1* and DQB1* genes on the rate of B-cells loss in a prospective series of 120 newly diagnosed T1DM subjects in the first 12 months after diagnosis . Is low-risk HLA genotype in Type 1 diabetes associated with less destruction of pancreatic B-cells 12 months after diagnosis?### Assistant: Low-risk HLA genotype in T1DM is associated with less destruction of pancreatic B-cells up to 12 months after diagnosis. These results are useful when designing trials for therapies aimed to prevent the progression of B-cell destruction in recent-onset T1DM.

Low-risk HLA genotype in T1DM is associated with less destruction of pancreatic B-cells up to 12 months after

Does treatment of sleep apnoea syndrome decrease cognitive decline in patients with Alzheimer 's disease?

CPAP therapy for sleep apnoea syndrome (SAS) slowed the rate of cognitive decline in mild-to-moderate AD patients . Of the 23 included patients, 14 underwent CPAP treatment . The median annual annual annual MMSE decline was significantly slower in the CPAP group (-0.7 (-1.7; +0.8) than in the non-CPAP group . The CPAP and non’CPAP groups did not differ significantly in terms of demographic characteristics or MMSE score at baseline .

In this pilot study, CPAP treatment of severe SAS in mild-to-moderate AD patients was associated with significantly slower cognitive decline over a three-year follow-up period. Our results emphasise the importance of detecting and treating SAS in this population.

yes

### Human: CPAP therapy for sleep apnoea syndrome (SAS) slowed the rate of cognitive decline in mild-to-moderate AD patients . Of the 23 included patients, 14 underwent CPAP treatment . The median annual annual annual MMSE decline was significantly slower in the CPAP group (-0.7 (-1.7; +0.8) than in the non-CPAP group . The CPAP and non’CPAP groups did not differ significantly in terms of demographic characteristics or MMSE score at baseline . Does treatment of sleep apnoea syndrome decrease cognitive decline in patients with Alzheimer 's disease?### Assistant: In this pilot study, CPAP treatment of severe SAS in mild-to-moderate AD patients was associated with significantly slower cognitive decline over a three-year follow-up period. Our results emphasise the importance of detecting and treating SAS in this population.

CPAP treatment of severe SAS in mild-to-moderate AD patients was associated with significantly slower cognitive decline over a three-year follow

Does acetylcholine receptor agonist reduce brain damage induced by hypoxia-ischemia in newborn rats?

7-day-old Wistar rats were subjected to carotid artery ligation followed by 2 hours of hypoxia (8% oxygen) and 2 hours hypoxic loading . After 7 days, 25% of the Carb/HI group showed mild neural damage, 75% showed no damage . 80% of Saline/HI and HI groups had severe neural damage . Neurodamage significantly decreased in Carb or HI compared with Saline or HI and HI for CA1, CA2, CA3, and the dentate gyrus of hippocampal regions .

Acetylcholine receptor agonist has a potent effect by reducing perinatal brain damage induced by HI in newborn rats.

yes

### Human: 7-day-old Wistar rats were subjected to carotid artery ligation followed by 2 hours of hypoxia (8% oxygen) and 2 hours hypoxic loading . After 7 days, 25% of the Carb/HI group showed mild neural damage, 75% showed no damage . 80% of Saline/HI and HI groups had severe neural damage . Neurodamage significantly decreased in Carb or HI compared with Saline or HI and HI for CA1, CA2, CA3, and the dentate gyrus of hippocampal regions . Does acetylcholine receptor agonist reduce brain damage induced by hypoxia-ischemia in newborn rats?### Assistant: Acetylcholine receptor agonist has a potent effect by reducing perinatal brain damage induced by HI in newborn rats.

Acetylcholine receptor agonist has a potent effect by reducing perinatal brain damage induced by HI in newborn rats . HI

Does intrathecal administration of prostaglandin E2 cause sensitization of the primary afferent neuron via the spinal release of glutamate?

Intrathecal PGE2 (2.5-50 ng/rat) administration caused a dose-dependent hyperalgesia in both paws . Ipsilateral intraplantar injections of morphine or SNAP (S-nitroso-N-acetyl-D,L-penicillamine, 50-200) micrograms/paw) dose-dependently antagonized spinally-induced PGE1 hyperalgeia . The spinally induced PGE 2 hyperalgedia was antagonized by intrathecal injections of AP5 (2-amino-5-phosphonopentanoate/2-AMino-Five)

Intrathecal administration of PGE2 seems to cause hyperalgesia by spinal sensitization of the primary afferent neuron through the release of glutamate.

yes

### Human: Intrathecal PGE2 (2.5-50 ng/rat) administration caused a dose-dependent hyperalgesia in both paws . Ipsilateral intraplantar injections of morphine or SNAP (S-nitroso-N-acetyl-D,L-penicillamine, 50-200) micrograms/paw) dose-dependently antagonized spinally-induced PGE1 hyperalgeia . The spinally induced PGE 2 hyperalgedia was antagonized by intrathecal injections of AP5 (2-amino-5-phosphonopentanoate/2-AMino-Five) Does intrathecal administration of prostaglandin E2 cause sensitization of the primary afferent neuron via the spinal release of glutamate?### Assistant: Intrathecal administration of PGE2 seems to cause hyperalgesia by spinal sensitization of the primary afferent neuron through the release of glutamate.

Administration of PGE2 seems to cause hyperalgesia by spinal sensitization of the primary afferent neuron through the release of glutamate

Does elf5 inhibit TGF-β-driven epithelial-mesenchymal transition in prostate cancer by repressing SMAD3 activation?

The epithelial-mesenchymal transition (EMT) has been associated with the acquisition of migration, invasiveness, and metastasis traits . During tumor progression, EMT can be induced by transforming growth factor-β (TGF-β) signal that epithelial cells receive from their microenvironment . The master regulatory controls on the TGF-beta-EMT axis are not understood . The protein expression in human specimens was measured by immunohistochemical staining . The study found that Elf5 results in the failure of mesenchyal morphogenesis, upregulation of EMT markers, spheres formation, and migration in the presence of TGF

Elf5 expression is inversely correlated with EMT. Elf5 inhibits TGF-β-driven EMT via repressing SMAD3 phosphorylation in prostate cancer cells. In addition, Elf5 can be used as a biomarker of metastasis-free survival in patients with TGF-β-positive prostate cancer.

yes

### Human: The epithelial-mesenchymal transition (EMT) has been associated with the acquisition of migration, invasiveness, and metastasis traits . During tumor progression, EMT can be induced by transforming growth factor-β (TGF-β) signal that epithelial cells receive from their microenvironment . The master regulatory controls on the TGF-beta-EMT axis are not understood . The protein expression in human specimens was measured by immunohistochemical staining . The study found that Elf5 results in the failure of mesenchyal morphogenesis, upregulation of EMT markers, spheres formation, and migration in the presence of TGF Does elf5 inhibit TGF-β-driven epithelial-mesenchymal transition in prostate cancer by repressing SMAD3 activation?### Assistant: Elf5 expression is inversely correlated with EMT. Elf5 inhibits TGF-β-driven EMT via repressing SMAD3 phosphorylation in prostate cancer cells. In addition, Elf5 can be used as a biomarker of metastasis-free survival in patients with TGF-β-positive prostate cancer.

Elf5 inhibits TGF-β-driven EMT via repressing SMAD3 phosphorylation in prostate cancer cells . In addition

Does videodermatoscopy enhance diagnostic capability in some forms of hair loss?

The goal of this study was to determine if videodermatoscopy enhances diagnostic capability beyond standard clinical observation in three series of patients . The study was conducted with patients with overt alopecia areata (AA), one with overt androgenetic alopepecia (AGA) and one with hair loss with no apparent diagnostic features . In all groups, videodermetoscopy was performed at magnifications ranging from 20x to 600x . In chronic AA patients, videoodermatoscope showed a scalp skin that appeared smooth and thin, with evident follicular openings . In some patients with chronic AA, videdermatoscopics also revealed hair regrowth, which appeared either as homogeneous, indicating early disease remission (upright 'vellus' hairs), or as sparse, thin, and twisted

The results indicate that videodermatoscopy represents a very useful tool in the evaluation of hair loss, both for differential diagnosis (especially in early, transitional and mild forms) and for prognostic evaluation. It allows rapid, detailed, and non-invasive observation of the scalp skin and hair, and it provides high-resolution quality imaging.

yes

### Human: The goal of this study was to determine if videodermatoscopy enhances diagnostic capability beyond standard clinical observation in three series of patients . The study was conducted with patients with overt alopecia areata (AA), one with overt androgenetic alopepecia (AGA) and one with hair loss with no apparent diagnostic features . In all groups, videodermetoscopy was performed at magnifications ranging from 20x to 600x . In chronic AA patients, videoodermatoscope showed a scalp skin that appeared smooth and thin, with evident follicular openings . In some patients with chronic AA, videdermatoscopics also revealed hair regrowth, which appeared either as homogeneous, indicating early disease remission (upright 'vellus' hairs), or as sparse, thin, and twisted Does videodermatoscopy enhance diagnostic capability in some forms of hair loss?### Assistant: The results indicate that videodermatoscopy represents a very useful tool in the evaluation of hair loss, both for differential diagnosis (especially in early, transitional and mild forms) and for prognostic evaluation. It allows rapid, detailed, and non-invasive observation of the scalp skin and hair, and it provides high-resolution quality imaging.

The results indicate that videodermatoscopy represents a very useful tool in the evaluation of hair loss . It allows rapid, detailed,

Does immunotherapy with Imiquimod increase the efficacy of Glucantime therapy of Leishmania major infection?

Imiquimod plus Glucantime has the highest efficacy in treatment of Leishmania major infection in BALB/c mice . The results were confirmed by parasite load of infected footpad of mice . Imiquiimod is another rational approach for the treatment of the disease . The immunological state of the host appears to play an important role in the efficacy of the treatment . The data shows that treatment of Leishmaniasis by the combined Imiquimiod and . combined Glucentime is more efficient than each drug alone .

The combination of Imiquimod with chemotherapy may offer a way for more efficient treatment of leishmaniasis.

yes

### Human: Imiquimod plus Glucantime has the highest efficacy in treatment of Leishmania major infection in BALB/c mice . The results were confirmed by parasite load of infected footpad of mice . Imiquiimod is another rational approach for the treatment of the disease . The immunological state of the host appears to play an important role in the efficacy of the treatment . The data shows that treatment of Leishmaniasis by the combined Imiquimiod and . combined Glucentime is more efficient than each drug alone . Does immunotherapy with Imiquimod increase the efficacy of Glucantime therapy of Leishmania major infection?### Assistant: The combination of Imiquimod with chemotherapy may offer a way for more efficient treatment of leishmaniasis.

Imiquimod with chemotherapy may offer a way for more efficient treatment of leishmaniasis .

Does hepatic iron overload induce hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein?

The aim of this study was to determine whether iron overload contributes to development of hepatocellular carcinoma (HCC) in transgenic mice expressing the hepatitis C virus (HCV) polyprotein . Hepatic iron concentrations in mice fed the excess-iron diet were comparable to those of patients with chronic hepatitis C . There was no inflammation in transgenial and nontransgenic livers. Hepatic tumors including HCC developed in 5 of 11 (45%) transgenic mouse fed the extra-iron diets .

Iron overload induces mitochondrial injury and increases the risk of HCC development in transgenic mice expressing the HCV polyprotein.

yes

### Human: The aim of this study was to determine whether iron overload contributes to development of hepatocellular carcinoma (HCC) in transgenic mice expressing the hepatitis C virus (HCV) polyprotein . Hepatic iron concentrations in mice fed the excess-iron diet were comparable to those of patients with chronic hepatitis C . There was no inflammation in transgenial and nontransgenic livers. Hepatic tumors including HCC developed in 5 of 11 (45%) transgenic mouse fed the extra-iron diets . Does hepatic iron overload induce hepatocellular carcinoma in transgenic mice expressing the hepatitis C virus polyprotein?### Assistant: Iron overload induces mitochondrial injury and increases the risk of HCC development in transgenic mice expressing the HCV polyprotein.

Iron overload induces mitochondrial injury and increases the risk of HCC development in transgenic mice expressing the HCV polyprotein .

Are xenohormone transactivities inversely associated to serum POPs in Inuit?

Greenlandic Inuit have high intake of marine food and thus high POP burden that varies according to local conditions and dietary preference . The xenoestrogenic and xenoandrogenic transactivities correlated negatively to the POPs for the combined female and male data, respectively . In fact, the xenohormone transactivity differed between districts as well as between the genders . Associations between the transactivity and age, n-3/n-6 and smoker years were observed .

The non-steroidal xenohormone transactivities can be used as an integrated biomarker of POP exposure and lifestyle characteristics. The actual serum POP mixtures antagonized the age adjusted sex hormone receptor functions. Comparison of different study populations requires in addition to age inclusion of diet and lifestyle factors.

yes

### Human: Greenlandic Inuit have high intake of marine food and thus high POP burden that varies according to local conditions and dietary preference . The xenoestrogenic and xenoandrogenic transactivities correlated negatively to the POPs for the combined female and male data, respectively . In fact, the xenohormone transactivity differed between districts as well as between the genders . Associations between the transactivity and age, n-3/n-6 and smoker years were observed . Are xenohormone transactivities inversely associated to serum POPs in Inuit?### Assistant: The non-steroidal xenohormone transactivities can be used as an integrated biomarker of POP exposure and lifestyle characteristics. The actual serum POP mixtures antagonized the age adjusted sex hormone receptor functions. Comparison of different study populations requires in addition to age inclusion of diet and lifestyle factors.

The actual serum POP mixtures antagonized the age adjusted sex hormone receptor functions . Comparison of different study populations requires in addition to age inclusion

Is routine use of a transanastomotic stent unnecessary for hepatojejunostomy in liver transplantation?

The use of transanastomotic stents for Roux-en-Y hepatojejunostomy (RYHJ) in liver transplantation remains controversial . The aim of this retrospective study was to assess the role of the stent for RYHJ in LT . The two groups were compared in terms of post-LT biliary complications and survival . There was no significant difference between the two groups in terms of the incidence of various biliary complications and survival (P > 0.05)

The routine use of transanastomotic stents is not necessary for RYHJ for biliary reconstruction in LT.

yes

### Human: The use of transanastomotic stents for Roux-en-Y hepatojejunostomy (RYHJ) in liver transplantation remains controversial . The aim of this retrospective study was to assess the role of the stent for RYHJ in LT . The two groups were compared in terms of post-LT biliary complications and survival . There was no significant difference between the two groups in terms of the incidence of various biliary complications and survival (P > 0.05) Is routine use of a transanastomotic stent unnecessary for hepatojejunostomy in liver transplantation?### Assistant: The routine use of transanastomotic stents is not necessary for RYHJ for biliary reconstruction in LT.

The routine use of transanastomotic stents is not necessary for RYHJ for biliary reconstruction in LT . The

Is cHRNA3 variant for lung cancer associated with chronic obstructive pulmonary disease in Korea?

CHRNA3 has been identified as a lung cancer and chronic obstructive pulmonary disease candidate gene in non-Hispanic Caucasian cohorts . However, there are differences in minor allele frequencies among ethnic groups, and limited data exists for Asian populations . The aim of this case-control study was to determine whether there is an association between COPD and genetic variation in CHRN3 in the Korean population . In addition, we investigated the association of CHRNA2 with intermediate disease phenotypes including emphysema and lung function in COPD subjects .

Genetic variations in CHRNA3 are associated with COPD in the Korean population.

yes

### Human: CHRNA3 has been identified as a lung cancer and chronic obstructive pulmonary disease candidate gene in non-Hispanic Caucasian cohorts . However, there are differences in minor allele frequencies among ethnic groups, and limited data exists for Asian populations . The aim of this case-control study was to determine whether there is an association between COPD and genetic variation in CHRN3 in the Korean population . In addition, we investigated the association of CHRNA2 with intermediate disease phenotypes including emphysema and lung function in COPD subjects . Is cHRNA3 variant for lung cancer associated with chronic obstructive pulmonary disease in Korea?### Assistant: Genetic variations in CHRNA3 are associated with COPD in the Korean population.

Genetic variations in CHRNA3 are associated with COPD in the Korean population .

Do in silico analysis of polymorphisms in microRNAs that target genes affecting aerobic glycolysis?

MicroRNAs (miRNAs) are non-coding RNAs that posttranscriptionally regulate gene expression and are dysregulated in the pathogenesis of various types of human cancers . Single nucleotide polymorphisms (SNPs) in miRNA genes may affect miRNA biogenesis, processing, function, and stability . These SNPs in premiRNAs target genes that control aerobic glycolysis indirectly . These miRNas target genes directly or indirectly controlling aerobic glycoslysis .

Our results raise the possibility that integration of SNP analysis in miRNA genes with studies of metabolic adaptations in cancer cells could provide greater understanding of oncogenic mechanisms.

yes

### Human: MicroRNAs (miRNAs) are non-coding RNAs that posttranscriptionally regulate gene expression and are dysregulated in the pathogenesis of various types of human cancers . Single nucleotide polymorphisms (SNPs) in miRNA genes may affect miRNA biogenesis, processing, function, and stability . These SNPs in premiRNAs target genes that control aerobic glycolysis indirectly . These miRNas target genes directly or indirectly controlling aerobic glycoslysis . Do in silico analysis of polymorphisms in microRNAs that target genes affecting aerobic glycolysis?### Assistant: Our results raise the possibility that integration of SNP analysis in miRNA genes with studies of metabolic adaptations in cancer cells could provide greater understanding of oncogenic mechanisms.

SNP analysis in miRNA genes with studies of metabolic adaptations in cancer cells could provide greater understanding of oncogenic mechanisms .

Does pressure elevation slow the fibroblast response to wound healing?

Wounds at atmospheric pressure plus 30 mm Hg healed by day 3, those at pressure plus 60mm Hg by day 4, and those grown at pressure . Wound edge fluorescence analysis demonstrated less fluorescence in each group compared with atmospheric pressure . Significantly less proliferating cell nuclear antigen activity was present in cells grown at atmospheric pressures plus 60 mm HG and atmospheric pressure + 120mm HG (P < .02) Wounds were healed by days 3, 4 days for those grown in a pressure incubator .

In this model of wound healing under pressure, neonatal fibroblasts grown to confluence and given a standardized wound displayed characteristics consistent with delayed healing. Elevated pressure has a role in the delayed migration and proliferation seen in this model.

yes

### Human: Wounds at atmospheric pressure plus 30 mm Hg healed by day 3, those at pressure plus 60mm Hg by day 4, and those grown at pressure . Wound edge fluorescence analysis demonstrated less fluorescence in each group compared with atmospheric pressure . Significantly less proliferating cell nuclear antigen activity was present in cells grown at atmospheric pressures plus 60 mm HG and atmospheric pressure + 120mm HG (P < .02) Wounds were healed by days 3, 4 days for those grown in a pressure incubator . Does pressure elevation slow the fibroblast response to wound healing?### Assistant: In this model of wound healing under pressure, neonatal fibroblasts grown to confluence and given a standardized wound displayed characteristics consistent with delayed healing. Elevated pressure has a role in the delayed migration and proliferation seen in this model.

Neonatal fibroblasts grown to confluence and given a standardized wound displayed characteristics consistent with delayed healing . Elevated pressure has a

Does diurnal rhythm rather than dietary iron mediate daily hepcidin variations?

Concentrations of hepcidin have been shown to increase during the day in individuals who are following a regular diet . It is currently unknown whether these increases are determined by an innate rhythm or by other factors . We aimed to assess the effect of dietary iron on heptidin concentrations during a day . 32 volunteers received an iron-deficient diet on 1 day and the same diet supplemented with 65 mg ferrous fumarate at 0815 and 1145 on another day . During the day with iron supplementation the mean TS was significantly higher both in men and in women .

Our data demonstrate that ferritin sets the basal hepcidin concentrations and suggest that innate diurnal rhythm rather than dietary iron mediates the daily hepcidin variations. These findings will be useful for optimizing sampling protocols and will facilitate the interpretation of hepcidin as an iron biomarker.

yes

### Human: Concentrations of hepcidin have been shown to increase during the day in individuals who are following a regular diet . It is currently unknown whether these increases are determined by an innate rhythm or by other factors . We aimed to assess the effect of dietary iron on heptidin concentrations during a day . 32 volunteers received an iron-deficient diet on 1 day and the same diet supplemented with 65 mg ferrous fumarate at 0815 and 1145 on another day . During the day with iron supplementation the mean TS was significantly higher both in men and in women . Does diurnal rhythm rather than dietary iron mediate daily hepcidin variations?### Assistant: Our data demonstrate that ferritin sets the basal hepcidin concentrations and suggest that innate diurnal rhythm rather than dietary iron mediates the daily hepcidin variations. These findings will be useful for optimizing sampling protocols and will facilitate the interpretation of hepcidin as an iron biomarker.

Our data demonstrate that ferritin sets the basal hepcidin concentrations and suggest that innate diurnal rhythm rather than dietary iron medi

Is the -202 A allele of insulin-like growth factor binding protein-3 ( IGFBP3 ) promoter polymorphism associated with higher IGFBP-3 serum levels and better growth response to growth hormone treatment in patients with severe growth hormone deficiency?

The aim of the study was to assess the influence of a polymorphism in the IGF-binding protein-3 promoter region (-202 A/C) on circulating IGFBP-3 levels and growth response to rhGH therapy in children with GH deficiency (GHD) Patients homozygous for the A genotype presented higher IGFBP3 sd score levels and higher mean GV in the first year of rhGH treatment than patients with AC or CC genotypes . The influence of -202 A-C IGFBP 3 genotype on IGFBP levels and GV during the first-year of rh GH treatment was independent of other variables .

The -202 A allele of IGFBP3 promoter region is associated with increased IGFBP-3 levels and GV during rhGH treatment in prepubertal GHD children.

yes

### Human: The aim of the study was to assess the influence of a polymorphism in the IGF-binding protein-3 promoter region (-202 A/C) on circulating IGFBP-3 levels and growth response to rhGH therapy in children with GH deficiency (GHD) Patients homozygous for the A genotype presented higher IGFBP3 sd score levels and higher mean GV in the first year of rhGH treatment than patients with AC or CC genotypes . The influence of -202 A-C IGFBP 3 genotype on IGFBP levels and GV during the first-year of rh GH treatment was independent of other variables . Is the -202 A allele of insulin-like growth factor binding protein-3 ( IGFBP3 ) promoter polymorphism associated with higher IGFBP-3 serum levels and better growth response to growth hormone treatment in patients with severe growth hormone deficiency?### Assistant: The -202 A allele of IGFBP3 promoter region is associated with increased IGFBP-3 levels and GV during rhGH treatment in prepubertal GHD children.

The -202 A allele of IGFBP3 promoter region is associated with increased IGFBP-3 levels and GV during rhGH treatment